TY - JOUR T1 - Stepwise Expansion of the Bacteriophage Ie6 Procapsid: Possible Packaging Intermediates AN - 911154741; 16073113 AB - The initial assembly product of bacteriophage Ie6, the procapsid, undergoes major structural transformation during the sequential packaging of its three segments of single-stranded RNA. The procapsid, a compact icosahedrally symmetric particle with deeply recessed vertices, expands to the spherical mature capsid, increasing the volume available to accommodate the genome by 2.5-fold. It has been proposed that expansion and packaging are linked, with each stage in expansion presenting a binding site for a particular RNA segment. To investigate procapsid transformability, we induced expansion by acidification, heating, and elevated salt concentration. Cryo-electron microscopy reconstructions after all three treatments yielded the same partially expanded particle. Analysis by cryo-electron tomography showed that all vertices of a given capsid were either in a compact or an expanded state, indicating a highly cooperative transition. To benchmark the mature capsid, we analyzed filled (in vivo packaged) capsids. When these particles were induced to release their RNA, they reverted to the same intermediate state as expanded procapsids (intermediate 1) or to a second, further expanded state (intermediate 2). This partial reversibility of expansion suggests that the mature spherical capsid conformation is obtained only when sufficient outward pressure is exerted by packaged RNA. The observation of two intermediates is consistent with the proposed three-step packaging process. The model is further supported by the observation that a mutant capable of packaging the second RNA segment without previously packaging the first segment has enhanced susceptibility for switching spontaneously from the procapsid to the first intermediate state. JF - Journal of Molecular Biology AU - Nemecek, Daniel AU - Cheng, Naiqian AU - Qiao, Jian AU - Mindich, Leonard AU - Steven, Alasdair C AU - Heymann, JBernard AD - National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA, stevena@mail.nih.gov Y1 - 2011/11/25/ PY - 2011 DA - 2011 Nov 25 SP - 260 EP - 271 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 414 IS - 2 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - cryo-electron microscopy KW - Cystoviridae KW - virus KW - capsid KW - segmented genome KW - Transformation KW - Genomes KW - Phages KW - Capsids KW - Bacteria KW - Procapsids KW - Models KW - Salts KW - RNA KW - Microscopy KW - Tomography KW - Acidification KW - Pressure KW - Conformation KW - A 01490:Miscellaneous KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911154741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Stepwise+Expansion+of+the+Bacteriophage+Ie6+Procapsid%3A+Possible+Packaging+Intermediates&rft.au=Nemecek%2C+Daniel%3BCheng%2C+Naiqian%3BQiao%2C+Jian%3BMindich%2C+Leonard%3BSteven%2C+Alasdair+C%3BHeymann%2C+JBernard&rft.aulast=Nemecek&rft.aufirst=Daniel&rft.date=2011-11-25&rft.volume=414&rft.issue=2&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2011.10.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Capsids; Phages; Genomes; Transformation; Procapsids; Models; Salts; RNA; Microscopy; Tomography; Acidification; Pressure; Conformation; Bacteria DO - http://dx.doi.org/10.1016/j.jmb.2011.10.004 ER - TY - JOUR T1 - Risk of renal cell carcinoma in relation to blood telomere length in a population-based case-control study AN - 1008840200; 16450958 AB - Background: There are few known risk factors for renal cell carcinoma (RCC). Two small hospital-based case-control studies suggested an association between short blood telomere length (TL) and increased RCC risk. Methods: We conducted a large population-based case-control study in two metropolitan regions of the United States comparing relative TL in DNA derived from peripheral blood samples from 891 RCC cases and 894 controls. Odds ratios and 95% confidence intervals were estimated using unconditional logistic regression in both unadjusted and adjusted models. Results: Median TL was 0.85 for both cases and controls (P=0.40), and no differences in RCC risk by quartiles of TL were observed. Results of analyses stratified by age, sex, race, tumour stage, and time from RCC diagnosis to blood collection were similarly null. In multivariate analyses among controls, increasing age and history of hypertension were associated with shorter TL (P<0.001 and P=0.07, respectively), and African Americans had longer TL than Caucasians (P<0.001). Conclusion: These data do not support the hypothesis that blood TL is associated with RCC. This population-based case-control study is, to our knowledge, the largest investigation to date of TL and RCC. JF - British Journal of Cancer AU - Hofmann, J N AU - Baccarelli, A AU - Schwartz, K AU - Davis, F G AU - Ruterbusch, J J AU - Hoxha, M AU - McCarthy, B J AU - Savage, S A AU - Wacholder, S AU - Rothman, N AU - Graubard, B I AU - Colt, J S AU - Chow, W-H AU - Purdue, M P AD - Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, EPS 8109, Bethesda, MD 20892-7240, USA Y1 - 2011/11/22/ PY - 2011 DA - 2011 Nov 22 SP - 1772 EP - 1775 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 105 IS - 11 SN - 0007-0920, 0007-0920 KW - Biochemistry Abstracts 2: Nucleic Acids; Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Age KW - Data processing KW - Peripheral blood KW - Cancer KW - Telomeres KW - USA KW - renal cell carcinoma KW - Multivariate analysis KW - Risk factors KW - hypertension KW - Regression analysis KW - DNA KW - metropolitan areas KW - Ethnic groups KW - Metropolitan areas KW - Races KW - Hypertension KW - Sex KW - H 11000:Diseases/Injuries/Trauma KW - N 14820:DNA Metabolism & Structure KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1008840200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Risk+of+renal+cell+carcinoma+in+relation+to+blood+telomere+length+in+a+population-based+case-control+study&rft.au=Hofmann%2C+J+N%3BBaccarelli%2C+A%3BSchwartz%2C+K%3BDavis%2C+F+G%3BRuterbusch%2C+J+J%3BHoxha%2C+M%3BMcCarthy%2C+B+J%3BSavage%2C+S+A%3BWacholder%2C+S%3BRothman%2C+N%3BGraubard%2C+B+I%3BColt%2C+J+S%3BChow%2C+W-H%3BPurdue%2C+M+P&rft.aulast=Hofmann&rft.aufirst=J&rft.date=2011-11-22&rft.volume=105&rft.issue=11&rft.spage=1772&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fbjc.2011.444 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Telomeres; Age; Data processing; renal cell carcinoma; Multivariate analysis; Risk factors; DNA; Regression analysis; Peripheral blood; Races; Sex; Hypertension; Historical account; hypertension; metropolitan areas; Metropolitan areas; Ethnic groups; Cancer; USA DO - http://dx.doi.org/10.1038/bjc.2011.444 ER - TY - JOUR T1 - Fifty years of diazeniumdiolate research. From laboratory curiosity to broad-spectrum biomedical advances. AN - 905676299; 21932836 AB - Here I show that a "pure" research project, seemingly totally lacking in practical application when it was first published, can years later spark a whole new scientific field with the potential to revolutionize clinical practice. A 1961 publication describing adducts of nitric oxide (NO) with certain nucleophiles attracted little notice at the time, but later work showing that the adducts could be hydrolyzed to regenerate the NO in bioactive form has provided the foundation for a host of biomedical applications. Crucial to the discovery of widely used tools for studying NO's chemical biology as well as for the design of a variety of promising therapeutic advances has been the increasingly detailed understanding of the physicochemical properties of these "diazeniumdiolates" (also known as NONOates). JF - ACS chemical biology AU - Keefer, Larry K AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Maryland 21702, United States. Y1 - 2011/11/18/ PY - 2011 DA - 2011 Nov 18 SP - 1147 EP - 1155 VL - 6 IS - 11 KW - Azo Compounds KW - 0 KW - Protons KW - diazeniumdiolate KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Animals KW - Spectrum Analysis KW - Humans KW - Nitric Oxide -- metabolism KW - Azo Compounds -- chemical synthesis KW - Azo Compounds -- metabolism KW - Biomedical Research KW - Azo Compounds -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/905676299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+chemical+biology&rft.atitle=Fifty+years+of+diazeniumdiolate+research.+From+laboratory+curiosity+to+broad-spectrum+biomedical+advances.&rft.au=Keefer%2C+Larry+K&rft.aulast=Keefer&rft.aufirst=Larry&rft.date=2011-11-18&rft.volume=6&rft.issue=11&rft.spage=1147&rft.isbn=&rft.btitle=&rft.title=ACS+chemical+biology&rft.issn=1554-8937&rft_id=info:doi/10.1021%2Fcb200274r LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-02 N1 - Date created - 2011-11-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurosurgery. 2001 Oct;49(4):945-51; discussion 951-3 [11564257] Chem Commun (Camb). 2011 Jun 21;47(23):6710-2 [21556407] Circulation. 2002 Jun 11;105(23):2779-84 [12057994] J Org Chem. 2003 Jan 24;68(2):656-7 [12530906] Hepatology. 2003 Feb;37(2):324-33 [12540782] Mol Cancer Ther. 2003 Apr;2(4):409-17 [12700285] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5537-42 [12704230] J Am Chem Soc. 2003 May 21;125(20):6068-9 [12785832] Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9196-201 [12865500] Free Radic Biol Med. 2004 Sep 15;37(6):745-52 [15304250] J Am Chem Soc. 2004 Oct 13;126(40):12880-7 [15469285] J Natl Cancer Inst. 1972 May;48(5):1389-92 [5030954] J Med Chem. 1973 May;16(5):583-5 [4577985] Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973 May 7;79(3):141-4 [4270219] Food Cosmet Toxicol. 1976 Apr;14(2):133-5 [178581] J Natl Cancer Inst. 1980 Jun;64(6):1435-42 [6929379] IARC Sci Publ. 1982;(41):21-9 [7141531] IARC Sci Publ. 1982;(41):625-31 [7141570] Nature. 1987 Jun 11-17;327(6122):524-6 [3495737] Biochem Pharmacol. 1988 Jul 1;37(13):2495-501 [3291879] Cancer Lett. 1988 Sep-Oct;42(1-2):141-5 [3180033] Nature. 1988 Nov 24;336(6197):385-8 [2904125] Biochem Biophys Res Commun. 1988 Nov 30;157(1):87-94 [3196352] Biochemistry. 1988 Nov 29;27(24):8706-11 [3242600] J Med Chem. 1991 Nov;34(11):3242-7 [1956043] J Cardiovasc Pharmacol. 1993 Aug;22(2):287-92 [7692171] Thromb Haemost. 1993 Oct 18;70(4):654-8 [8115991] J Med Chem. 1996 Mar 1;39(5):1148-56 [8676352] Methods Enzymol. 1996;268:281-93 [8782594] J Med Chem. 1996 Oct 25;39(22):4361-5 [8893830] J Med Chem. 1997 Jun 20;40(13):1947-54 [9207935] J Neurosurg. 1997 Nov;87(5):746-51 [9347984] Bioconjug Chem. 1999 Sep-Oct;10(5):838-42 [10502351] J Am Chem Soc. 2005 Apr 20;127(15):5388-95 [15826177] J Med Chem. 2005 Jun 16;48(12):4061-7 [15943479] J Am Chem Soc. 2005 Oct 19;127(41):14188-9 [16218605] Nitric Oxide. 2005 Nov;13(3):204-9 [16122951] J Med Chem. 2005 Dec 29;48(26):8220-8 [16366603] J Med Chem. 2000 Jan 27;43(2):261-9 [10649981] Transplantation. 2001 Jan 27;71(2):193-8 [11213058] J Org Chem. 2001 May 4;66(9):3090-8 [11325274] J Am Chem Soc. 2001 Jun 13;123(23):5465-72 [11389628] J Am Chem Soc. 2001 Jun 13;123(23):5473-81 [11389629] Nitric Oxide. 2001 Aug;5(4):377-94 [11485376] Inorg Chem. 2006 Mar 20;45(6):2448-56 [16529464] J Med Chem. 2006 Jul 13;49(14):4356-66 [16821795] J Am Chem Soc. 2007 Apr 4;129(13):3786-7 [17343382] Blood. 2007 Jul 15;110(2):709-18 [17384201] Org Lett. 2007 Aug 16;9(17):3409-12 [17658755] Free Radic Biol Med. 2008 Jan 1;44(1):73-81 [18045549] J Med Chem. 2008 Jul 10;51(13):3961-70 [18533711] Angew Chem Int Ed Engl. 2009;48(47):8909-13 [19852010] Org Lett. 2010 Oct 1;12(19):4256-9 [20812718] J Am Chem Soc. 2010 Nov 24;132(46):16526-32 [21033665] J Pharmacol Exp Ther. 2011 Feb;336(2):313-20 [20962031] Inorg Chem. 2011 Apr 18;50(8):3262-70 [21405089] Biomaterials. 2002 Mar;23(6):1485-94 [11829445] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/cb200274r ER - TY - JOUR T1 - Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications. AN - 904009163; 21609791 AB - Aldehyde dehydrogenases (ALDHs) represent large family members of NAD(P)+-dependent dehydrogenases responsible for the irreversible metabolism of many endogenous and exogenous aldehydes to the corresponding acids. Among 19 ALDH isozymes, mitochondrial ALDH2 is a low Km enzyme responsible for the metabolism of acetaldehyde and lipid peroxides such as malondialdehyde and 4-hydroxynonenal, both of which are highly reactive and toxic. Consequently, inhibition of ALDH2 would lead to elevated levels of acetaldehyde and other reactive lipid peroxides following ethanol intake and/or exposure to toxic chemicals. In addition, many East Asian people with a dominant negative mutation in ALDH2 gene possess a decreased ALDH2 activity with increased risks for various types of cancer, myocardial infarct, alcoholic liver disease, and other pathological conditions. The aim of this review is to briefly describe the multiple post-translational modifications of mitochondrial ALDH2, as an example, after exposure to toxic chemicals or under different disease states and their pathophysiological roles in promoting alcohol/drug-mediated tissue damage. We also briefly mention exciting preclinical translational research opportunities to identify small molecule activators of ALDH2 and its isozymes as potentially therapeutic/preventive agents against various disease states where the expression or activity of ALDH enzymes is altered or inactivated. Published by Elsevier B.V. JF - Journal of proteomics AU - Song, Byoung-Joon AU - Abdelmegeed, Mohamed A AU - Yoo, Seong-Ho AU - Kim, Bong-Jo AU - Jo, Sangmee A AU - Jo, Inho AU - Moon, Kwan-Hoon AD - Section of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892-9410, USA. bj.song@nih.gov Y1 - 2011/11/18/ PY - 2011 DA - 2011 Nov 18 SP - 2691 EP - 2702 VL - 74 IS - 12 KW - Enzyme Activators KW - 0 KW - Lipid Peroxides KW - Mitochondrial Proteins KW - ALDH2 protein, human KW - EC 1.2.1.3 KW - Aldehyde Dehydrogenase KW - Aldehyde Dehydrogenase, Mitochondrial KW - Acetaldehyde KW - GO1N1ZPR3B KW - Index Medicus KW - Neoplasms -- drug therapy KW - Animals KW - Myocardial Infarction -- enzymology KW - Neoplasms -- enzymology KW - Myocardial Infarction -- genetics KW - Humans KW - Acetaldehyde -- metabolism KW - Asian Continental Ancestry Group -- genetics KW - Neoplasms -- genetics KW - Enzyme Activators -- therapeutic use KW - Liver Diseases, Alcoholic -- enzymology KW - Liver Diseases, Alcoholic -- genetics KW - Genes, Dominant KW - Risk Factors KW - Liver Diseases, Alcoholic -- drug therapy KW - Lipid Peroxides -- metabolism KW - Mutation KW - Myocardial Infarction -- drug therapy KW - Mitochondrial Proteins -- agonists KW - Aldehyde Dehydrogenase -- genetics KW - Protein Processing, Post-Translational KW - Mitochondrial Proteins -- genetics KW - Mitochondrial Proteins -- metabolism KW - Aldehyde Dehydrogenase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904009163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+proteomics&rft.atitle=Post-translational+modifications+of+mitochondrial+aldehyde+dehydrogenase+and+biomedical+implications.&rft.au=Song%2C+Byoung-Joon%3BAbdelmegeed%2C+Mohamed+A%3BYoo%2C+Seong-Ho%3BKim%2C+Bong-Jo%3BJo%2C+Sangmee+A%3BJo%2C+Inho%3BMoon%2C+Kwan-Hoon&rft.aulast=Song&rft.aufirst=Byoung-Joon&rft.date=2011-11-18&rft.volume=74&rft.issue=12&rft.spage=2691&rft.isbn=&rft.btitle=&rft.title=Journal+of+proteomics&rft.issn=1876-7737&rft_id=info:doi/10.1016%2Fj.jprot.2011.05.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-01 N1 - Date created - 2011-11-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Hypertens Res. 2002 Sep;25(5):677-81 [12452318] Electrophoresis. 2002 Dec;23(24):4142-56 [12481271] Mol Pharmacol. 2003 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6121061 JF - 18th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2011) AU - Hwang, PaulNB Y1 - 2011/11/16/ PY - 2011 DA - 2011 Nov 16 KW - Cancer KW - Metabolism KW - p53 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313038089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2011%29&rft.atitle=p53%2C+aerobic+metabolism+and+cancer&rft.au=Hwang%2C+PaulNB&rft.aulast=Hwang&rft.aufirst=PaulNB&rft.date=2011-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2011%29&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2011.08.114 L2 - http://submissions.miracd.com/sfrbm2011/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Leptin is key to macrophage-dependent free radical formation in CCl4-induced exacerbation of steatohepatitis of obesity T2 - 18th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2011) AN - 1313026155; 6121316 JF - 18th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2011) AU - Chatterjee, Saurabh AU - Tokar, Erik AU - Kadiiska, Maria AU - Waalkes, Michael AU - Mae Diehl, Anna AU - Mason, Ronald Y1 - 2011/11/16/ PY - 2011 DA - 2011 Nov 16 KW - Obesity KW - Leptin KW - Free radicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313026155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2011%29&rft.atitle=Leptin+is+key+to+macrophage-dependent+free+radical+formation+in+CCl4-induced+exacerbation+of+steatohepatitis+of+obesity&rft.au=Chatterjee%2C+Saurabh%3BTokar%2C+Erik%3BKadiiska%2C+Maria%3BWaalkes%2C+Michael%3BMae+Diehl%2C+Anna%3BMason%2C+Ronald&rft.aulast=Chatterjee&rft.aufirst=Saurabh&rft.date=2011-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2011/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Effect of intermittent pneumatic compression of legs on blood nitric oxide and brachial artery diameter T2 - 18th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2011) AN - 1313009602; 6121290 JF - 18th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2011) AU - Nagababu, EnikaNB AU - Salgado, MariaNB AU - Lima, SandraNB AU - Lima, MichaelNB AU - Silber, HarryNB AU - Rifkind, JosephNB Y1 - 2011/11/16/ PY - 2011 DA - 2011 Nov 16 KW - Nitric oxide KW - Blood KW - Leg KW - Arteries KW - Compression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313009602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2011%29&rft.atitle=Effect+of+intermittent+pneumatic+compression+of+legs+on+blood+nitric+oxide+and+brachial+artery+diameter&rft.au=Nagababu%2C+EnikaNB%3BSalgado%2C+MariaNB%3BLima%2C+SandraNB%3BLima%2C+MichaelNB%3BSilber%2C+HarryNB%3BRifkind%2C+JosephNB&rft.aulast=Nagababu&rft.aufirst=EnikaNB&rft.date=2011-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2011/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - New and improved immuno-spin trapping methods for the detection of DNA radicals T2 - 18th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2011) AN - 1312964590; 6121329 JF - 18th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2011) AU - Summers, FionaNB AU - Mason, RonaldNB AU - Ehrenshaft, MarilynNB Y1 - 2011/11/16/ PY - 2011 DA - 2011 Nov 16 KW - Radicals KW - Trapping UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312964590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2011%29&rft.atitle=New+and+improved+immuno-spin+trapping+methods+for+the+detection+of+DNA+radicals&rft.au=Summers%2C+FionaNB%3BMason%2C+RonaldNB%3BEhrenshaft%2C+MarilynNB&rft.aulast=Summers&rft.aufirst=FionaNB&rft.date=2011-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2011/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - The effects of resveratrol and selected metabolites on the radiation and antioxidant response. AN - 912797249; 22024758 AB - Excess reactive oxygen species (ROS) generated from ionizing radiation (IR) or endogenous sources like cellular respiration and inflammation produce cytotoxic effects that can lead to carcinogenesis. Resveratrol (RSV), a polyphenol with antioxidant and anticarcinogenic capabilities, has shown promise as a potential radiation modifier. The present study focuses on examining the effects of RSV or RSV metabolites as a radiation modifier in normal tissue. RSV or a RSV metabolite, piceatannol (PIC) did not protect human lung fibroblasts (1522) from the radiation-induced cell killing. Likewise, neither RSV nor PIC afforded protection against lethal total body IR in C3H mice. Additional research has shown protection in cells against hydrogen peroxide when treated with RSV. Therefore, clonogenic survival was measured in 1522 cells with RSV and RSV metabolites. Only the RSV derivative, piceatannol (PIC), showed protection against hydrogen peroxide mediated cytotoxicity; whereas, RSV enhanced hydrogen peroxide sensitivity at a 50 µM concentration; the remaining metabolites evaluated had little to no effect on survival. PIC also showed enhancement to peroxide exposure at a higher concentration (150 µM). A potential mechanism for RSV-induced sensitivity to peroxides could be its ability to block 1522 cells in the S-phase, which is most sensitive to hydrogen peroxide treatment. In addition, both RSV and PIC can be oxidized to phenoxyl radicals and quinones, which may exert cytotoxic effects. These cytotoxic effects were abolished when HBED, a metal chelator, was added. Taken together RSV and many of its metabolic derivatives are not effective as chemical radioprotectors and should not be considered for clinical use. JF - Cancer biology & therapy AU - Fabre, Kristin M AU - Saito, Keita AU - DeGraff, William AU - Sowers, Anastasia L AU - Thetford, Angela AU - Cook, John A AU - Krishna, Murali C AU - Mitchell, James B AD - Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA. fabrek@mail.nih.gov Y1 - 2011/11/15/ PY - 2011 DA - 2011 Nov 15 SP - 915 EP - 923 VL - 12 IS - 10 KW - Antioxidants KW - 0 KW - Phenols KW - Quinones KW - Radiation-Protective Agents KW - Stilbenes KW - phenoxy radical KW - 3229-70-7 KW - N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid KW - 35998-29-9 KW - 3,3',4,5'-tetrahydroxystilbene KW - 6KS3LS0D4F KW - tert-Butylhydroperoxide KW - 955VYL842B KW - Edetic Acid KW - 9G34HU7RV0 KW - Hydrogen Peroxide KW - BBX060AN9V KW - resveratrol KW - Q369O8926L KW - Index Medicus KW - Animals KW - Fibroblasts -- drug effects KW - Dose-Response Relationship, Drug KW - Humans KW - Phenols -- metabolism KW - Mice KW - Fibroblasts -- metabolism KW - Quinones -- metabolism KW - Hydrogen Peroxide -- toxicity KW - Edetic Acid -- analogs & derivatives KW - Whole-Body Irradiation KW - Cell Survival -- drug effects KW - Oxidative Stress -- drug effects KW - Mice, Inbred C3H KW - Fibroblasts -- radiation effects KW - Cell Survival -- radiation effects KW - tert-Butylhydroperoxide -- toxicity KW - Cell Cycle -- drug effects KW - Edetic Acid -- pharmacology KW - Female KW - Antioxidants -- metabolism KW - Antioxidants -- pharmacology KW - Stilbenes -- pharmacology KW - Radiation-Protective Agents -- metabolism KW - Radiation-Protective Agents -- pharmacology KW - Stilbenes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912797249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=The+effects+of+resveratrol+and+selected+metabolites+on+the+radiation+and+antioxidant+response.&rft.au=Fabre%2C+Kristin+M%3BSaito%2C+Keita%3BDeGraff%2C+William%3BSowers%2C+Anastasia+L%3BThetford%2C+Angela%3BCook%2C+John+A%3BKrishna%2C+Murali+C%3BMitchell%2C+James+B&rft.aulast=Fabre&rft.aufirst=Kristin&rft.date=2011-11-15&rft.volume=12&rft.issue=10&rft.spage=915&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=1555-8576&rft_id=info:doi/10.4161%2Fcbt.12.10.17714 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-17 N1 - Date created - 2011-12-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Free Radic Biol Med. 2001 Jan 15;30(2):170-7 [11163534] Chem Biol Interact. 2011 Aug 15;193(1):34-42 [21570383] Cancer Lett. 2002 Jan 25;175(2):165-73 [11741744] Mil Med. 2002 Feb;167(2 Suppl):49-50 [11873514] Pharm Res. 2002 Dec;19(12):1907-14 [12523673] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5390-5 [12702779] Biochem Biophys Res Commun. 2003 Oct 3;309(4):1017-26 [13679076] Int J Mol Med. 2004 Jun;13(6):895-902 [15138632] Radiat Res. 1970 Jun;42(3):451-70 [5463516] Radiat Res. 1984 Mar;97(3):598-607 [6328565] Radiat Res. 1987 Sep;111(3):385-405 [3659275] Prog Nucleic Acid Res Mol Biol. 1988;35:95-125 [3065826] Radiat Res. 1989 Jun;118(3):437-66 [2727270] Int J Radiat Biol. 1994 Jan;65(1):27-33 [7905906] Prog Clin Biol Res. 1995;391:103-16 [8532709] Ann N Y Acad Sci. 1998 Nov 20;854:425-34 [9928449] Science. 1963 May 3;140(3566):490-2 [13980636] Int J Mol Med. 2005 Feb;15(2):337-52 [15647852] Biochem Pharmacol. 2005 Mar 15;69(6):903-12 [15748702] Int J Mol Med. 2005 Jun;15(6):1005-12 [15870907] Mutat Res. 2005 Jul 1;574(1-2):124-38 [15914212] J Radiat Res. 2005 Dec;46(4):387-93 [16394628] Nat Rev Drug Discov. 2006 Jun;5(6):493-506 [16732220] Oncol Rep. 2006 Sep;16(3):617-24 [16865264] J Mol Histol. 2006 Sep;37(5-7):203-18 [16868862] Cancer Lett. 2007 Aug 8;253(1):124-30 [17321671] Drug Discov Today. 2007 Oct;12(19-20):794-805 [17933679] Chem Res Toxicol. 2008 Jan;21(1):93-101 [18052105] Apoptosis. 2008 Jun;13(6):790-802 [18454317] Radiat Res. 2008 Jun;169(6):633-8 [18494544] Radiat Res. 2008 Dec;170(6):784-93 [19138034] Int J Radiat Oncol Biol Phys. 2009 May 1;74(1):219-28 [19362240] Drug Metab Rev. 2009;41(2):89-295 [19514967] Environ Mol Mutagen. 2009 Dec;50(9):771-80 [19449395] Anticancer Drugs. 2010 Feb;21(2):140-50 [20010425] Toxicol In Vitro. 2010 Apr;24(3):916-20 [19945524] Oncologist. 2010;15(4):360-71 [20413641] Crit Rev Food Sci Nutr. 2009 Oct;49(9):782-99 [20443159] Science. 1949 Aug 26;110(2852):213-4 [17811258] Free Radic Res. 2009;43(11):1060-71 [19707923] J Radiat Res. 2010;51(4):473-9 [20679743] PLoS One. 2010;5(8):e12124 [20711342] Semin Oncol. 2010 Jun;37(3):258-81 [20709209] Oxid Med Cell Longev. 2010 Mar-Apr;3(2):86-100 [20716933] Nutr Cancer. 2010;62(7):938-46 [20924969] Ann N Y Acad Sci. 2011 Jan;1215:48-59 [21261641] Int J Mol Med. 2011 Mar;27(3):441-6 [21249311] Mutat Res. 2011 Jun 3;711(1-2):193-201 [21216256] EMBO J. 2001 Jun 1;20(11):2896-906 [11387222] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4161/cbt.12.10.17714 ER - TY - JOUR T1 - Effects of ascorbic acid on carcinogenicity and acute toxicity of nickel subsulfide, and on tumor transplants growth in gulonolactone oxidase knock-out mice and wild-type C57BL mice AN - 911168502; 16076117 AB - The aim of this study was to test a hypothesis that ascorbate depletion could enhance carcinogenicity and acute toxicity of nickel. Homozygous l-gulono-gamma>-lactone oxidase gene knock-out mice (Gulo-/- mice) unable to produce ascorbate and wild-type C57BL mice (WT mice) were injected intramuscularly with carcinogenic nickel subsulfide (Ni3S2), and observed for the development of injection site tumors for 57weeks. Small pieces of one of the induced tumors were transplanted subcutaneously into separate groups of Gulo-/- and WT mice and the growth of these tumors was measured for up to 3months. The two strains of mice differed significantly with regard to (1) Ni3S2 carcinogenesis: Gulo-/- mice were 40% more susceptible than WT mice; and (2) transplanted tumors development: Gulo-/- mice were more receptive to tumor growth than WT mice, but only in terms of a much shorter tumor latency; later in the exponential phase of growth, the growth rates were the same. And, with adequate ascorbate supplementation, the two strains were equally susceptible to acute toxicity of Ni3S2. Statistically significant effects of dietary ascorbate dosing levels were the following: (1) reduction in ascorbate supplementation increased acute toxicity of Ni3S2 in Gulo-/- mice; (2) ascorbate supplementation extended the latency of transplanted tumors in WT mice. In conclusion, the lack of endogenous ascorbate synthesis makes Gulo-/- mice more susceptible to Ni3S2 carcinogenesis. Dietary ascorbate tends to attenuate acute toxicity of Ni3S2 and to extend the latency of transplanted tumors. The latter effects may be of practical importance to humans and thus deserve further studies. JF - Toxicology and Applied Pharmacology AU - Kasprzak, Kazimierz S AU - Diwan, Bhalchandra A AU - Kaczmarek, Monika Z AU - Logsdon, Daniel L AU - Fivash, Mathew J AU - Salnikow, Konstantin AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA, salnikok@mail.nih.gov Y1 - 2011/11/15/ PY - 2011 DA - 2011 Nov 15 SP - 32 EP - 37 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 257 IS - 1 SN - 0041-008X, 0041-008X KW - Toxicology Abstracts KW - Growth rate KW - Dietary supplements KW - Nickel KW - Carcinogenesis KW - Statistical analysis KW - Tumors KW - Acute toxicity KW - Ascorbic acid KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911168502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Effects+of+ascorbic+acid+on+carcinogenicity+and+acute+toxicity+of+nickel+subsulfide%2C+and+on+tumor+transplants+growth+in+gulonolactone+oxidase+knock-out+mice+and+wild-type+C57BL+mice&rft.au=Kasprzak%2C+Kazimierz+S%3BDiwan%2C+Bhalchandra+A%3BKaczmarek%2C+Monika+Z%3BLogsdon%2C+Daniel+L%3BFivash%2C+Mathew+J%3BSalnikow%2C+Konstantin&rft.aulast=Kasprzak&rft.aufirst=Kazimierz&rft.date=2011-11-15&rft.volume=257&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2011.08.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Growth rate; Dietary supplements; Carcinogenesis; Nickel; Statistical analysis; Acute toxicity; Tumors; Ascorbic acid DO - http://dx.doi.org/10.1016/j.taap.2011.08.015 ER - TY - JOUR T1 - Myeloablative doses of yttrium-90-ibritumomab tiuxetan and the risk of secondary myelodysplasia/acute myelogenous leukemia. AN - 902332333; 21567384 AB - Because the long-term toxicity of myeloablative radioimmunotherapy remains a matter of concern, the authors evaluated the hematopoietic damage and incidence of secondary myelodysplastic syndrome and acute myelogenous leukemia (sMDS/AML) in patients who received myeloablative doses of the radiolabeled antibody yttrium-90 (⁹⁰Y)-ibritumomab tiuxetan. The occurrence of sMDS/AML was investigated prospectively in 53 elderly patients with non-Hodgkin lymphoma (NHL) who underwent an autograft after high-dose radioimmunotherapy (HD-RIT) myeloablative conditioning with ⁹⁰Y-ibritumomab tiuxetan. Bone marrow (BM) hematopoietic progenitors and telomere length (TL) also were investigated. At a median follow-up of 49 months, 4 patients developed sMDS/AML at 6 months, 12 months, 27 months, and 36 months after HD-RIT, and the 5-year cumulative incidence of sMDS/AML was 8.29%. A significant but transient decrease in BM granulocyte-macrophage progenitors was observed; whereas multilineage, erythroid, and fibroblast progenitors were unaffected. A significant and persistent shortening of BM TL also was detected. A matched-pair analysis comparing the study patients with 55 NHL patients who underwent autografts after chemotherapy-based myeloablative conditioning demonstrated a 8.05% 5-year cumulative incidence of sMDS/AML. HD-RIT for patients with NHL was associated with 1) limited toxicity on hematopoietic progenitors, 2) accelerated TL shortening, and 3) non-negligible incidence of sMDS/AML, which nevertheless was comparable to the incidence observed in a matched group of patients who received chemotherapy-based conditioning. Thus, in the current series of elderly patients with NHL, the development of sMDS/AML was not influenced substantially by HD-RIT. Copyright © 2011 American Cancer Society. JF - Cancer AU - Guidetti, Anna AU - Carlo-Stella, Carmelo AU - Ruella, Marco AU - Miceli, Rosalba AU - Devizzi, Lilli AU - Locatelli, Silvia L AU - Giacomini, Arianna AU - Testi, Adele AU - Buttiglieri, Stefano AU - Risso, Alessandra AU - Mariani, Luigi AU - Di Nicola, Massimo AU - Passera, Roberto AU - Tarella, Corrado AU - Gianni, Alessandro M AD - Medical Oncology 3, National Cancer Institute, Milan, Italy. Y1 - 2011/11/15/ PY - 2011 DA - 2011 Nov 15 SP - 5074 EP - 5084 VL - 117 IS - 22 KW - Antibodies, Monoclonal KW - 0 KW - Yttrium Radioisotopes KW - ibritumomab tiuxetan KW - 4Q52C550XK KW - Abridged Index Medicus KW - Index Medicus KW - Bone Marrow -- pathology KW - Humans KW - Hematopoietic Stem Cells -- cytology KW - Aged KW - Hematopoietic Stem Cells -- drug effects KW - Risk KW - Lymphoma, Non-Hodgkin -- drug therapy KW - Telomere -- drug effects KW - Lymphoma, Non-Hodgkin -- radiotherapy KW - Adult KW - Granulocyte-Macrophage Progenitor Cells -- cytology KW - Telomere -- radiation effects KW - Middle Aged KW - Follow-Up Studies KW - Bone Marrow -- radiation effects KW - Bone Marrow -- drug effects KW - Hematopoietic Stem Cells -- radiation effects KW - Male KW - Female KW - Yttrium Radioisotopes -- therapeutic use KW - Neoplasms, Second Primary -- etiology KW - Radioimmunotherapy -- adverse effects KW - Leukemia, Myeloid, Acute -- etiology KW - Yttrium Radioisotopes -- adverse effects KW - Antibodies, Monoclonal -- adverse effects KW - Myelodysplastic Syndromes -- etiology KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902332333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Myeloablative+doses+of+yttrium-90-ibritumomab+tiuxetan+and+the+risk+of+secondary+myelodysplasia%2Facute+myelogenous+leukemia.&rft.au=Guidetti%2C+Anna%3BCarlo-Stella%2C+Carmelo%3BRuella%2C+Marco%3BMiceli%2C+Rosalba%3BDevizzi%2C+Lilli%3BLocatelli%2C+Silvia+L%3BGiacomini%2C+Arianna%3BTesti%2C+Adele%3BButtiglieri%2C+Stefano%3BRisso%2C+Alessandra%3BMariani%2C+Luigi%3BDi+Nicola%2C+Massimo%3BPassera%2C+Roberto%3BTarella%2C+Corrado%3BGianni%2C+Alessandro+M&rft.aulast=Guidetti&rft.aufirst=Anna&rft.date=2011-11-15&rft.volume=117&rft.issue=22&rft.spage=5074&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=1097-0142&rft_id=info:doi/10.1002%2Fcncr.26182 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-09 N1 - Date created - 2011-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/cncr.26182 ER - TY - CPAPER T1 - Nicotine preexposure in periadolescence or early adulthood alters the aversive, physiological and reinforcing effects of alcohol. T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313102885; 6106610 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Rinker, J AU - DeCicco-Skinner, K AU - Thorsell, A AU - Heilig, M AU - Riley, A Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Nicotine KW - alcohols KW - Physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313102885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Decreased+microRNA-214+levels+in+breast+cancer+cells+coincides+with+increased+cell+proliferation%2C+invasion+and+accumulation+of+the+Polycomb+Ezh2+methyltransferase&rft.au=Derfoul%2C+Assia%3BJuan%2C+Aster+H%3BDifilippantonio%2C+Michael+J%3BPalanisamy%2C+Nallasivam%3BRied%2C+Thomas%3BSartorelli%2C+Vittorio&rft.aulast=Derfoul&rft.aufirst=Assia&rft.date=2011-11-01&rft.volume=32&rft.issue=11&rft.spage=1607&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgr184 L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Early postnatal NMDA receptor ablation alters interneuronal activity in a mouse model of schizophrenia T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313099063; 6105569 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Zsiros, V AU - Nakazawa, K Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Mental disorders KW - Schizophrenia KW - Animal models KW - N-Methyl-D-aspartic acid receptors KW - Glutamic acid receptors (ionotropic) KW - Ablation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313099063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Early+postnatal+NMDA+receptor+ablation+alters+interneuronal+activity+in+a+mouse+model+of+schizophrenia&rft.au=Zsiros%2C+V%3BNakazawa%2C+K&rft.aulast=Zsiros&rft.aufirst=V&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Hippocampal volume shows rapid increases in response to exercise in sedentary adults T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313062978; 6106466 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Thomas, A AU - Dennis, A AU - Rawlings, N AU - Matthews, L AU - Stagg, C AU - Morris, M AU - Bandettini, P AU - Dawes, H AU - Johansen-Berg, H Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Hippocampus KW - Physical training UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313062978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Hippocampal+volume+shows+rapid+increases+in+response+to+exercise+in+sedentary+adults&rft.au=Thomas%2C+A%3BDennis%2C+A%3BRawlings%2C+N%3BMatthews%2C+L%3BStagg%2C+C%3BMorris%2C+M%3BBandettini%2C+P%3BDawes%2C+H%3BJohansen-Berg%2C+H&rft.aulast=Thomas&rft.aufirst=A&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Decreased mature synapses and increased excitability of cortical neurons in transgenic mice expressing the schizophrenia associated KCNH2 3.1 isoform T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313062926; 6105066 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Chen, J AU - Yuan, P AU - Tian, Q AU - Yang, F AU - Zhang, G AU - Jia, J AU - Wang, Y AU - Du, J. AU - Glineburg, P AU - Carr, G AU - Papaleo, F AU - Pickel, J AU - Li, Z. AU - Daniel, W Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Mental disorders KW - Mice KW - Schizophrenia KW - Cortex KW - Excitability KW - Synapses KW - Transgenic mice KW - Neurons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313062926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Decreased+mature+synapses+and+increased+excitability+of+cortical+neurons+in+transgenic+mice+expressing+the+schizophrenia+associated+KCNH2+3.1+isoform&rft.au=Chen%2C+J%3BYuan%2C+P%3BTian%2C+Q%3BYang%2C+F%3BZhang%2C+G%3BJia%2C+J%3BWang%2C+Y%3BDu%2C+J.%3BGlineburg%2C+P%3BCarr%2C+G%3BPapaleo%2C+F%3BPickel%2C+J%3BLi%2C+Z.%3BDaniel%2C+W&rft.aulast=Chen&rft.aufirst=J&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Vision in action: An ascending pulvinar path from brainstem to cortex T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313060356; 6104704 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Berman, R Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Vision KW - Cortex KW - Pulvinar KW - Brain stem UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313060356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Vision+in+action%3A+An+ascending+pulvinar+path+from+brainstem+to+cortex&rft.au=Berman%2C+R&rft.aulast=Berman&rft.aufirst=R&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Functional imaging of the interaction between anxiety and cognitive load T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313058284; 6104415 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Vytal, K AU - Robinson, O AU - Charney, D AU - Overstreet, C AU - Grillon, C Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Anxiety KW - Imaging techniques KW - Cognitive ability UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313058284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Functional+imaging+of+the+interaction+between+anxiety+and+cognitive+load&rft.au=Vytal%2C+K%3BRobinson%2C+O%3BCharney%2C+D%3BOverstreet%2C+C%3BGrillon%2C+C&rft.aulast=Liu&rft.aufirst=Xunxian&rft.date=2011-11-01&rft.volume=32&rft.issue=11&rft.spage=1648&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgr206 L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Oxytocin induces synaptic potentiation in hippocampal CA2 neurons T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313057755; 6105136 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Zhao, M AU - Young, 3rd, W. AU - Dudek, S Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Oxytocin KW - Potentiation KW - Hippocampus KW - Neurons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313057755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Oxytocin+induces+synaptic+potentiation+in+hippocampal+CA2+neurons&rft.au=Zhao%2C+M%3BYoung%2C+3rd%2C+W.%3BDudek%2C+S&rft.aulast=Zhao&rft.aufirst=M&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Hippocampal area CA2 is particularly sensitive to adenosine-induced synaptic depression T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313057706; 6105134 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Caruana, D AU - Simons, S AU - Dudek, S Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Depression KW - Hippocampus KW - synaptic depression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313057706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Hippocampal+area+CA2+is+particularly+sensitive+to+adenosine-induced+synaptic+depression&rft.au=Caruana%2C+D%3BSimons%2C+S%3BDudek%2C+S&rft.aulast=Caruana&rft.aufirst=D&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Common variation in the DARPP-32 gene is associated with presynaptic dopamine in healthy humans T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313054193; 6105020 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Eisenberg, D AU - Masdeu, J AU - Ianni, A AU - Baller, E AU - Kolachana, B AU - Weinberger, D AU - Berman, K Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - DARPP-32 protein KW - Dopamine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313054193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Common+variation+in+the+DARPP-32+gene+is+associated+with+presynaptic+dopamine+in+healthy+humans&rft.au=Eisenberg%2C+D%3BMasdeu%2C+J%3BIanni%2C+A%3BBaller%2C+E%3BKolachana%2C+B%3BWeinberger%2C+D%3BBerman%2C+K&rft.aulast=Eisenberg&rft.aufirst=D&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - N-arachidonyl glycine (NAGly) does not activate heterologously expressed G-protein receptor 18 (GPR18) in a native neuronal system T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313053996; 6103348 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Lu, V. AU - Puhl III, H AU - Ikeda, S Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Glycine KW - Guanine nucleotide-binding protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313053996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=N-arachidonyl+glycine+%28NAGly%29+does+not+activate+heterologously+expressed+G-protein+receptor+18+%28GPR18%29+in+a+native+neuronal+system&rft.au=Lu%2C+V.%3BPuhl+III%2C+H%3BIkeda%2C+S&rft.aulast=Lu&rft.aufirst=V.&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Chloride transporter expression and function in developing GnRH-1 neurons T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313052880; 6104273 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Taylorburds, C AU - Wray, S Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Chloride KW - Neurons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313052880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Chloride+transporter+expression+and+function+in+developing+GnRH-1+neurons&rft.au=Taylorburds%2C+C%3BWray%2C+S&rft.aulast=Taylorburds&rft.aufirst=C&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Integration of neuroendocrine signals on GnRH-1 neurons T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313052843; 6104271 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Klenke, U AU - Wray, S Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Integration KW - Neurons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313052843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Integration+of+neuroendocrine+signals+on+GnRH-1+neurons&rft.au=Klenke%2C+U%3BWray%2C+S&rft.aulast=Klenke&rft.aufirst=U&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Dopamine D5 receptor knockout mice display prefrontal cortex-dependent cognitive deficits T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313052090; 6104490 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Carr, G AU - Sibley, D AU - Weinberger, D AU - Papaleo, F Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Mice KW - Cognitive ability KW - Dopamine D5 receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313052090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Dopamine+D5+receptor+knockout+mice+display+prefrontal+cortex-dependent+cognitive+deficits&rft.au=Carr%2C+G%3BSibley%2C+D%3BWeinberger%2C+D%3BPapaleo%2C+F&rft.aulast=Carr&rft.aufirst=G&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Corticostriatal mediation of choice learning and flexibility in the mouse T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313051809; 6104482 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Brigman, J AU - Graybeal, C AU - Wright, T AU - Capik, N AU - Davis, M AU - Jiang, Z AU - Pease, M AU - Saksida, L AU - Bussey, T AU - Nakazawa, K AU - Lovinger, D AU - Holmes, A Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Choice learning KW - Cortex UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313051809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Corticostriatal+mediation+of+choice+learning+and+flexibility+in+the+mouse&rft.au=Brigman%2C+J%3BGraybeal%2C+C%3BWright%2C+T%3BCapik%2C+N%3BDavis%2C+M%3BJiang%2C+Z%3BPease%2C+M%3BSaksida%2C+L%3BBussey%2C+T%3BNakazawa%2C+K%3BLovinger%2C+D%3BHolmes%2C+A&rft.aulast=Brigman&rft.aufirst=J&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Time-lapse observation of synapse formation in vivo revealed that rapsyn transport and clustering requires acetylcholine receptors T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313051633; 6103464 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Park, J AU - Ikenaga, T AU - Ono, F Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - rapsyn KW - Protein transport KW - Acetylcholine receptors KW - Synaptogenesis KW - Neurotransmitters KW - Synapses UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313051633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Time-lapse+observation+of+synapse+formation+in+vivo+revealed+that+rapsyn+transport+and+clustering+requires+acetylcholine+receptors&rft.au=Park%2C+J%3BIkenaga%2C+T%3BOno%2C+F&rft.aulast=Park&rft.aufirst=J&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Cortico-nigral network synchronization across behavioral states: Motor activity, rest, sleep and anesthesia in a rodent model of Parkinson's disease T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313051217; 6104134 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Wahba, M AU - Brazhnik, E AU - Mccoy, A AU - Novikov, N AU - Ilieva, N AU - Walters, J Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Parkinson's disease KW - anesthesia KW - Rodents KW - Movement disorders KW - Neurodegenerative diseases KW - Animal models KW - Sleep KW - Anesthesia KW - Synchronization KW - Motor activity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313051217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Risk&rft.atitle=Clinical+risk+in+paediatrics%3A+Medicines&rft.au=Anderson%2C+Mark&rft.aulast=Anderson&rft.aufirst=Mark&rft.date=2011-11-01&rft.volume=17&rft.issue=6&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Clinical+Risk&rft.issn=13562622&rft_id=info:doi/10.1258%2Fcr.2011.011044 L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Polyamidoamine (PAMAM) dendrimer conjugates of neuroprotective adenosine receptor antagonists T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313049450; 6105821 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Jacobson, K AU - Kumar, T AU - Deflorian, F AU - Kecskes, A AU - Phan, K AU - Gao, Z AU - Tosh, D Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Adenosine receptors KW - Neuroprotection KW - Antagonists KW - polyamidoamines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313049450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Polyamidoamine+%28PAMAM%29+dendrimer+conjugates+of+neuroprotective+adenosine+receptor+antagonists&rft.au=Jacobson%2C+K%3BKumar%2C+T%3BDeflorian%2C+F%3BKecskes%2C+A%3BPhan%2C+K%3BGao%2C+Z%3BTosh%2C+D&rft.aulast=Jacobson&rft.aufirst=K&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Electron tomography of the GABAergic post-synaptic density in dissociated hippocampal neurons T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313046379; 6103460 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Linsalata, A AU - Chen, X AU - Winters, C AU - Reese, T Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Hippocampus KW - g-Aminobutyric acid KW - Tomography KW - Neurons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313046379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Electron+tomography+of+the+GABAergic+post-synaptic+density+in+dissociated+hippocampal+neurons&rft.au=Linsalata%2C+A%3BChen%2C+X%3BWinters%2C+C%3BReese%2C+T&rft.aulast=Linsalata&rft.aufirst=A&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Der+Pathologe&rft.issn=1432-1963&rft_id=info:doi/10.1007%2Fs00292-011-1475-6 L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - In-vivo optical measurement of direct- and indirect-pathway striatal neuron activity in mice performing an operant task T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313040826; 6104164 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Cui, G AU - Jun, S AU - Jin, X AU - Vogel, S AU - Lovinger, D AU - Costa, R Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Mice KW - Operant conditioning KW - Neostriatum KW - Neurons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313040826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=In-vivo+optical+measurement+of+direct-+and+indirect-pathway+striatal+neuron+activity+in+mice+performing+an+operant+task&rft.au=Cui%2C+G%3BJun%2C+S%3BJin%2C+X%3BVogel%2C+S%3BLovinger%2C+D%3BCosta%2C+R&rft.aulast=Cui&rft.aufirst=G&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - MEG reveals aberrant spontaneous, but not stimulus-dependant, neural synchrony in autism spectrum disorders T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313017031; 6106363 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Ghuman, A AU - Van Den Honert, R AU - Dixon, E AU - Robustelli, B AU - Wallace, G AU - Martin, A Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Autism KW - Magnetoencephalography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313017031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=MEG+reveals+aberrant+spontaneous%2C+but+not+stimulus-dependant%2C+neural+synchrony+in+autism+spectrum+disorders&rft.au=Ghuman%2C+A%3BVan+Den+Honert%2C+R%3BDixon%2C+E%3BRobustelli%2C+B%3BWallace%2C+G%3BMartin%2C+A&rft.aulast=Ghuman&rft.aufirst=A&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A Drosophila neuroligin regulates synaptic growth and function in response to activity and Phosphoinositide 3 kinase T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313015079; 6106078 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Mozer, B AU - Sandstrom, D Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - phosphoinositides KW - Synaptogenesis KW - Growth KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313015079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=A+Drosophila+neuroligin+regulates+synaptic+growth+and+function+in+response+to+activity+and+Phosphoinositide+3+kinase&rft.au=Mozer%2C+B%3BSandstrom%2C+D&rft.aulast=Mozer&rft.aufirst=B&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Gustatory interneurons in an insect respond to multiple tastants and with temporally complex firing patterns T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313014539; 6105762 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Reiter, S AU - Stopfer, M Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Insects KW - Firing pattern KW - Tastants KW - Interneurons KW - Aquatic insects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313014539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.atitle=super%2868%29Ga-DOTA-Affibody+molecule+for+in+vivo+assessment+of+HER2%2Fneu+expression+with+PET&rft.au=Kramer-Marek%2C+Gabriela%3BShenoy%2C+Nalini%3BSeidel%2C+Jurgen%3BGriffiths%2C+Gary+L%3BChoyke%2C+Peter%3BCapala%2C+Jacek&rft.aulast=Kramer-Marek&rft.aufirst=Gabriela&rft.date=2011-11-01&rft.volume=38&rft.issue=11&rft.spage=1967&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.issn=16197070&rft_id=info:doi/10.1007%2Fs00259-011-1810-4 L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Stress-induced modulation of glucocorticoid receptor expression in adult born neurons T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313012109; 6104985 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Carter, R AU - Cameron, H Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Neurons KW - Glucocorticoid receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313012109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Stress-induced+modulation+of+glucocorticoid+receptor+expression+in+adult+born+neurons&rft.au=Carter%2C+R%3BCameron%2C+H&rft.aulast=Carter&rft.aufirst=R&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - FGF8 expression is crucial for olfactory ensheathing cell development T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313011236; 6104928 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Forni, P AU - Bharti, K AU - Wray, S Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - olfactory ensheathing cells KW - Fibroblast growth factor 8 KW - Olfaction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313011236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=FGF8+expression+is+crucial+for+olfactory+ensheathing+cell+development&rft.au=Forni%2C+P%3BBharti%2C+K%3BWray%2C+S&rft.aulast=Forni&rft.aufirst=P&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Contribution of activity-dependent BDNF signaling to cortical slow-wave activity T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313008101; 6103481 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Hardy, N AU - Martinowich, K AU - Jimenez, D AU - Schloesser, R AU - Weinberger, D AU - Lu, B. Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Cortex KW - Brain-derived neurotrophic factor UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313008101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Contribution+of+activity-dependent+BDNF+signaling+to+cortical+slow-wave+activity&rft.au=Hardy%2C+N%3BMartinowich%2C+K%3BJimenez%2C+D%3BSchloesser%2C+R%3BWeinberger%2C+D%3BLu%2C+B.&rft.aulast=Hardy&rft.aufirst=N&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Neural correlates of bias towards neutral faces relative to fearful faces in healthy individuals T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313003701; 6102985 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Doty, T AU - Japee, S AU - Ingvar, M AU - Ungerleider, L Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Nervous system UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313003701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Neural+correlates+of+bias+towards+neutral+faces+relative+to+fearful+faces+in+healthy+individuals&rft.au=Doty%2C+T%3BJapee%2C+S%3BIngvar%2C+M%3BUngerleider%2C+L&rft.aulast=Doty&rft.aufirst=T&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Corticostriatal CB1 receptor modulation of goal-directed and habitual actions T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1312997244; 6104524 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Gremel, C AU - Luo, G AU - Lovinger, D AU - Costa, R Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Cortex KW - Cannabinoid CB1 receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312997244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Corticostriatal+CB1+receptor+modulation+of+goal-directed+and+habitual+actions&rft.au=Gremel%2C+C%3BLuo%2C+G%3BLovinger%2C+D%3BCosta%2C+R&rft.aulast=Gremel&rft.aufirst=C&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Oscillatory neural synchrony and information transmission rates in the insect olfactory system T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1312982907; 6105672 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Aldworth, Z AU - Stopfer, M Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Insects KW - Olfactory system KW - Information processing KW - Aquatic insects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312982907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Oscillatory+neural+synchrony+and+information+transmission+rates+in+the+insect+olfactory+system&rft.au=Aldworth%2C+Z%3BStopfer%2C+M&rft.aulast=Aldworth&rft.aufirst=Z&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Two critical and functionally distinct time periods for early face and body perception T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1312981569; 6105871 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Pitcher, D AU - Duchaine, B AU - Walsh, V AU - Kanwisher, N Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Perception KW - Face KW - Pattern recognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312981569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Two+critical+and+functionally+distinct+time+periods+for+early+face+and+body+perception&rft.au=Pitcher%2C+D%3BDuchaine%2C+B%3BWalsh%2C+V%3BKanwisher%2C+N&rft.aulast=Pitcher&rft.aufirst=D&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A-beta(1-42) impairs clearance of synapticallyreleased glutamate by the glial transporter GLT-1. T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1312977451; 6106345 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Scimemi, A AU - Meabon, J AU - Diamond, J AU - Cook, D Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Glutamic acid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312977451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=A-beta%281-42%29+impairs+clearance+of+synapticallyreleased+glutamate+by+the+glial+transporter+GLT-1.&rft.au=Scimemi%2C+A%3BMeabon%2C+J%3BDiamond%2C+J%3BCook%2C+D&rft.aulast=Scimemi&rft.aufirst=A&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Striosomal and extended striatal expression of the CB1 cannabinoid receptor during development and in the mature mouse T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1312973710; 6103355 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Davis, M AU - Lovinger, D Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Cannabinoid CB1 receptors KW - Neostriatum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312973710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Striosomal+and+extended+striatal+expression+of+the+CB1+cannabinoid+receptor+during+development+and+in+the+mature+mouse&rft.au=Davis%2C+M%3BLovinger%2C+D&rft.aulast=Davis&rft.aufirst=M&rft.date=2011-11-12&rft.volume=49&rft.issue=11&rft.spage=2820&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2011.07.067 L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Roles of inhibition of GSK-3 and HDACs in beneficial effects of combined lithium and valproate treatment in transgenic mouse models of Huntington's disease T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1312971326; 6106015 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Chiu, C AU - Liu, G AU - Leeds, P AU - Chuang, D Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Lithium KW - Animal models KW - Valproic acid KW - Histone deacetylase KW - Huntington's disease KW - Transgenic mice KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312971326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Roles+of+inhibition+of+GSK-3+and+HDACs+in+beneficial+effects+of+combined+lithium+and+valproate+treatment+in+transgenic+mouse+models+of+Huntington%27s+disease&rft.au=Chiu%2C+C%3BLiu%2C+G%3BLeeds%2C+P%3BChuang%2C+D&rft.aulast=Chiu&rft.aufirst=C&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Parallel changes in synaptic function and structural in the basal ganglia after chronic ethanol and cocaine exposure T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1312967887; 6105702 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Alvarez, V Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Ethanol KW - cocaine KW - Cocaine KW - Basal ganglia KW - Ganglia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312967887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Parallel+changes+in+synaptic+function+and+structural+in+the+basal+ganglia+after+chronic+ethanol+and+cocaine+exposure&rft.au=Alvarez%2C+V&rft.aulast=Alvarez&rft.aufirst=V&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Cytotoxicity of synthetic cannabinoids found in "Spice" products: The role of cannabinoid receptors and the caspase cascade in the NG 108-15 cell line AN - 902361862; 15784612 AB - The worldwide distribution of "Spice" that contains synthetic cannabinoids with a pharmacological activity similar to Delta 9-tetrahydrocannabinol has been reported. In the current study, we evaluated the cytotoxicity of the synthetic cannabinoids, CP-55,940, CP-47,497 and CP-47,497-C8 towards NG 108-15 cells and investigated their mechanism of cytotoxicity. CP-55,940, CP-47,497 and CP-47,497-C8 were all cytotoxic for NG 108-15 cells in a concentration-dependent manner. The cytotoxicity of these synthetic cannabinoids was suppressed by preincubation with the selective CB1 receptor antagonist AM251, but not with the selective CB2 receptor antagonist AM630. Preincubation with a caspase-3 inhibitor significantly suppressed the cytotoxicity of these synthetic cannabinoids for NG 108-15 cells. Induction of apoptosis by these cannabinoids was also confirmed by staining of the cells with annexin V. Our results indicate that the cytotoxicity of synthetic cannabinoids towards NG 108-15 cells is mediated by the CB1 receptor, but not by the CB2 receptor, and further suggest that caspase-cascades may play an important role in the apoptosis induced by these synthetic cannabinoids. JF - Toxicology Letters AU - Tomiyama, Kenichi AU - Funada, Masahiko AD - Department of Drug Dependence Research, National Institute of Mental Health. National Center of Neurology and Psychiatry, Japan, mfunada@ncnp.go.jp Y1 - 2011/11/10/ PY - 2011 DA - 2011 Nov 10 SP - 12 EP - 17 PB - Elsevier B.V., Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland VL - 207 IS - 1 SN - 0378-4274, 0378-4274 KW - Toxicology Abstracts KW - Annexin V KW - Cannabinoid CB2 receptors KW - X:24300 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902361862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Cytotoxicity+of+synthetic+cannabinoids+found+in+%22Spice%22+products%3A+The+role+of+cannabinoid+receptors+and+the+caspase+cascade+in+the+NG+108-15+cell+line&rft.au=Tomiyama%2C+Kenichi%3BFunada%2C+Masahiko&rft.aulast=Tomiyama&rft.aufirst=Kenichi&rft.date=2011-11-10&rft.volume=207&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2011.08.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Cannabinoid CB2 receptors DO - http://dx.doi.org/10.1016/j.toxlet.2011.08.021 ER - TY - JOUR T1 - Structural Insights into Ail-Mediated Adhesion in Yersinia pestis AN - 918057759; 16049336 AB - Ail is an outer membrane protein from Yersinia pestis that is highly expressed in a rodent model of bubonic plague, making it a good candidate for vaccine development. Ail is important for attaching to host cells and evading host immune responses, facilitating rapid progression of a plague infection. Binding to host cells is important for injection of cytotoxic Yersinia outer proteins. To learn more about how Ail mediates adhesion, we solved two high-resolution crystal structures of Ail, with no ligand bound and in complex with a heparin analog called sucrose octasulfate. We identified multiple adhesion targets, including laminin and heparin, and showed that a 40 kDa domain of laminin called LG4-5 specifically binds to Ail. We also evaluated the contribution of laminin to delivery of Yops to HEp-2 cells. This work constitutes a structural description of how a bacterial outer membrane protein uses a multivalent approach to bind host cells. JF - Structure AU - Yamashita, Satoshi AU - Lukacik, Petra AU - Barnard, Travis J AU - Noinaj, Nicholas AU - Felek, Suleyman AU - Tsang, Tiffany M AU - Krukonis, Eric S AU - Hinnebusch, BJoseph AU - Buchanan, Susan K AD - Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-8030, USA, skbuchan@helix.nih.gov Y1 - 2011/11/09/ PY - 2011 DA - 2011 Nov 09 SP - 1672 EP - 1682 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 United States VL - 19 IS - 11 SN - 0969-2126, 0969-2126 KW - Microbiology Abstracts B: Bacteriology KW - Laminin KW - outer membrane proteins KW - Animal models KW - Yersinia pestis KW - Infection KW - Cytotoxicity KW - Sucrose KW - Crystal structure KW - Plague KW - Vaccines KW - Immune response KW - Heparin KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918057759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Structure&rft.atitle=Structural+Insights+into+Ail-Mediated+Adhesion+in+Yersinia+pestis&rft.au=Yamashita%2C+Satoshi%3BLukacik%2C+Petra%3BBarnard%2C+Travis+J%3BNoinaj%2C+Nicholas%3BFelek%2C+Suleyman%3BTsang%2C+Tiffany+M%3BKrukonis%2C+Eric+S%3BHinnebusch%2C+BJoseph%3BBuchanan%2C+Susan+K&rft.aulast=Yamashita&rft.aufirst=Satoshi&rft.date=2011-11-09&rft.volume=19&rft.issue=11&rft.spage=1672&rft.isbn=&rft.btitle=&rft.title=Structure&rft.issn=09692126&rft_id=info:doi/10.1016%2Fj.str.2011.08.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Laminin; Cytotoxicity; outer membrane proteins; Sucrose; Animal models; Crystal structure; Immune response; Vaccines; Plague; Infection; Heparin; Yersinia pestis DO - http://dx.doi.org/10.1016/j.str.2011.08.010 ER - TY - JOUR T1 - An in vitro and in vivo study of a novel zinc complex, zinc N-(2-hydroxyacetophenone)glycinate to overcome multidrug resistance in cancer. AN - 898503909; 21717020 AB - Multiple drug resistance (MDR) remains a major clinical challenge for cancer treatment. P-glycoprotein is the major contributor and they exceed their role in the chemotherapy resistance of most of the malignancies. Attempts in several preclinical and clinical studies to reverse the MDR phenomenon by using MDR modulators have not yet generated promising results. In the present study, a co-ordination complex of zinc viz., Zn N-(2-hydroxyacetophenone)glycinate (ZnNG) has been synthesized, characterized and its antitumour activity was tested in vitro against drug sensitive and resistant human T-lymphoblastic leukemic cell lines (CCRF/CEM and CEM/ADR5000 respectively) and in vivo against Ehrlich ascites carcinoma (EAC) implanted in female Swiss albino mice. To evaluate the cytotoxic potential of ZnNG, we used sensitive CCRF/CEM and drug resistant CEM/ADR 5000 cell lines in vitro. Moreover, ZnNG also has the potential ability to reverse the multidrug resistance phenotype in drug resistant CEM/ADR 5000 cell line and induces apoptosis in combination with vinblastine. ZnNG remarkably increases the life span of Swiss albino mice bearing sensitive and doxorubicin resistant subline of EAC in presence and in absence of doxorubicin. In addition, intraperitoneal application of ZnNG in mice does not show any systemic toxicity in preliminary trials in normal mice. To conclude, a novel metal chelate of zinc viz., ZnNG, may be a promising therapeutic agent against sensitive as well as drug resistant cancers. JF - Dalton transactions (Cambridge, England : 2003) AU - Ghosh, Ruma Dey AU - Das, Satyajit AU - Ganguly, Avishek AU - Banerjee, Kaushik AU - Chakraborty, Paramita AU - Sarkar, Avijit AU - Chatterjee, Mitali AU - Nanda, Ashis AU - Pradhan, Kiran AU - Choudhuri, Soumitra K AD - Department of In Vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, 700 026, Kolkata, India. Y1 - 2011/11/07/ PY - 2011 DA - 2011 Nov 07 SP - 10873 EP - 10884 VL - 40 IS - 41 KW - Antineoplastic Agents KW - 0 KW - Coordination Complexes KW - P-Glycoprotein KW - Reactive Oxygen Species KW - Vinblastine KW - 5V9KLZ54CY KW - Doxorubicin KW - 80168379AG KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - Vinblastine -- pharmacology KW - Animals KW - Reactive Oxygen Species -- metabolism KW - Humans KW - Cell Line, Tumor KW - Mice KW - Carcinoma, Ehrlich Tumor KW - Zinc -- chemistry KW - Doxorubicin -- pharmacology KW - P-Glycoprotein -- genetics KW - P-Glycoprotein -- metabolism KW - Apoptosis -- drug effects KW - Female KW - Coordination Complexes -- chemical synthesis KW - Coordination Complexes -- pharmacology KW - Antineoplastic Agents -- chemical synthesis KW - Coordination Complexes -- chemistry KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- pharmacology KW - Drug Resistance, Neoplasm -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/898503909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dalton+transactions+%28Cambridge%2C+England+%3A+2003%29&rft.atitle=An+in+vitro+and+in+vivo+study+of+a+novel+zinc+complex%2C+zinc+N-%282-hydroxyacetophenone%29glycinate+to+overcome+multidrug+resistance+in+cancer.&rft.au=Ghosh%2C+Ruma+Dey%3BDas%2C+Satyajit%3BGanguly%2C+Avishek%3BBanerjee%2C+Kaushik%3BChakraborty%2C+Paramita%3BSarkar%2C+Avijit%3BChatterjee%2C+Mitali%3BNanda%2C+Ashis%3BPradhan%2C+Kiran%3BChoudhuri%2C+Soumitra+K&rft.aulast=Ghosh&rft.aufirst=Ruma&rft.date=2011-11-07&rft.volume=40&rft.issue=41&rft.spage=10873&rft.isbn=&rft.btitle=&rft.title=Dalton+transactions+%28Cambridge%2C+England+%3A+2003%29&rft.issn=1477-9234&rft_id=info:doi/10.1039%2Fc1dt10501a LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-02-10 N1 - Date created - 2011-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1039/c1dt10501a ER - TY - CPAPER T1 - Use of p16/ki67 Cytology to Detect Cervical Pre-cancer in a US Referral Population T2 - 59th Annual Scientific Meeting of the American Society of Cytopathology (ASC 2011) AN - 1313049676; 6068390 JF - 59th Annual Scientific Meeting of the American Society of Cytopathology (ASC 2011) AU - Wentzensen, Nicolas AU - Walker, Joan AU - Zuna, Rosemary AU - Dunn, Terence AU - Gold, Michael AU - Schiffman, Mark Y1 - 2011/11/04/ PY - 2011 DA - 2011 Nov 04 KW - Cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313049676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=59th+Annual+Scientific+Meeting+of+the+American+Society+of+Cytopathology+%28ASC+2011%29&rft.atitle=Use+of+p16%2Fki67+Cytology+to+Detect+Cervical+Pre-cancer+in+a+US+Referral+Population&rft.au=Wentzensen%2C+Nicolas%3BWalker%2C+Joan%3BZuna%2C+Rosemary%3BDunn%2C+Terence%3BGold%2C+Michael%3BSchiffman%2C+Mark&rft.aulast=Wentzensen&rft.aufirst=Nicolas&rft.date=2011-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Scientific+Meeting+of+the+American+Society+of+Cytopathology+%28ASC+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://cytopathologymeeting.org/2011/wp-content/uploads/2011/10/Final-Program1.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Spectrum of Cancer Risk Among US Solid Organ Transplant Recipients AN - 912920357; 16038381 AB - Context Solid organ transplant recipients have elevated cancer risk due to immunosuppression and oncogenic viral infections. Because most prior research has concerned kidney recipients, large studies that include recipients of differing organs can inform cancer etiology. OBJECTIVE: To describe the overall pattern of cancer following solid organ transplantion. Design, Setting, and Participants Cohort study using linked data on solid organ transplant recipients from the US Scientific Registry of Transplant Recipients (1987-2008) and 13 state and regional cancer registries. MAIN OUTCOME MEASURES: Standardized incidence ratios (SIRs) and excess absolute risks (EARs) assessing relative and absolute cancer risk in transplant recipients compared with the general population. RESULTS: The registry linkages yielded data on 175 732 solid organ transplants (58.4% for kidney, 21.6% for liver, 10.0% for heart, and 4.0% for lung). The overall cancer risk was elevated with 10 656 cases and an incidence of 1375 per 100 000 person-years (SIR, 2.10 [95% CI, 2.06-2.14]; EAR, 719.3 [95% CI, 693.3-745.6] per 100 000 person-years). Risk was increased for 32 different malignancies, some related to known infections (eg, anal cancer, Kaposi sarcoma) and others unrelated (eg, melanoma, thyroid and lip cancers). The most common malignancies with elevated risk were non-Hodgkin lymphoma (n = 1504; incidence: 194.0 per 100 000 person-years; SIR, 7.54 [95% CI, 7.17-7.93]; EAR, 168.3 [95% CI, 158.6-178.4] per 100 000 person-years) and cancers of the lung (n = 1344; incidence: 173.4 per 100 000 person-years; SIR, 1.97 [95% CI, 1.86-2.08]; EAR, 85.3 [95% CI, 76.2-94.8] per 100 000 person-years), liver (n = 930; incidence: 120.0 per 100 000 person-years; SIR, 11.56 [95% CI, 10.83-12.33]; EAR, 109.6 [95% CI, 102.0-117.6] per 100 000 person-years), and kidney (n = 752; incidence: 97.0 per 100 000 person-years; SIR, 4.65 [95% CI, 4.32-4.99]; EAR, 76.1 [95% CI, 69.3-83.3] per 100 000 person-years). Lung cancer risk was most elevated in lung recipients (SIR, 6.13 [95% CI, 5.18-7.21]) but also increased among other recipients (kidney: SIR, 1.46 [95% CI, 1.34-1.59]; liver: SIR, 1.95 [95% CI, 1.74-2.19]; and heart: SIR, 2.67 [95% CI, 2.40-2.95]). Liver cancer risk was elevated only among liver recipients (SIR, 43.83 [95% CI, 40.90-46.91]), who manifested exceptional risk in the first 6 months (SIR, 508.97 [95% CI, 474.16-545.66]) and a 2-fold excess risk for 10 to 15 years thereafter (SIR, 2.22 [95% CI, 1.57-3.04]). Among kidney recipients, kidney cancer risk was elevated (SIR, 6.66 [95% CI, 6.12-7.23]) and bimodal in onset time. Kidney cancer risk also was increased in liver recipients (SIR, 1.80 [95% CI, 1.40-2.29]) and heart recipients (SIR, 2.90 [95% CI, 2.32-3.59]). CONCLUSION: Compared with the general population, recipients of a kidney, liver, heart, or lung transplant have an increased risk for diverse infection-related and unrelated cancers. JF - JAMA: Journal of the American Medical Association AU - Engels, Eric A AU - Pfeiffer, Ruth M AU - Fraumeni, Joseph F AU - Kasiske, Bertram L AU - Israni, Ajay K AU - Snyder, Jon J AU - Wolfe, Robert A AU - Goodrich, Nathan P AU - Bayakly, ARana AU - Clarke, Christina A AU - Copeland, Glenn AU - Finch, Jack L AU - Fleissner, Mary Lou AU - Goodman, Marc T AU - Kahn, Amy AU - Koch, Lori AU - Lynch, Charles F AU - Madeleine, Margaret M AU - Pawlish, Karen AU - Rao, Chandrika AU - Williams, Melanie A AU - Castenson, David AU - Curry, Michael AU - Parsons, Ruth AU - Fant, Gregory AU - Lin, Monica AD - Author Affiliations: National Cancer Institute, Rockville, Maryland (Drs Engels, Pfeiffer, and Fraumeni) Y1 - 2011/11/02/ PY - 2011 DA - 2011 Nov 02 SP - 1891 EP - 1901 PB - American Medical Association, 515 N. State St. Chicago IL 60610 United States VL - 306 IS - 17 SN - 0098-7484, 0098-7484 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Thyroid KW - melanoma KW - Infection KW - Organs KW - Cancer KW - Melanoma KW - USA KW - Kidney KW - Liver KW - infection KW - Standards KW - Lung cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912920357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Spectrum+of+Cancer+Risk+Among+US+Solid+Organ+Transplant+Recipients&rft.au=Engels%2C+Eric+A%3BPfeiffer%2C+Ruth+M%3BFraumeni%2C+Joseph+F%3BKasiske%2C+Bertram+L%3BIsrani%2C+Ajay+K%3BSnyder%2C+Jon+J%3BWolfe%2C+Robert+A%3BGoodrich%2C+Nathan+P%3BBayakly%2C+ARana%3BClarke%2C+Christina+A%3BCopeland%2C+Glenn%3BFinch%2C+Jack+L%3BFleissner%2C+Mary+Lou%3BGoodman%2C+Marc+T%3BKahn%2C+Amy%3BKoch%2C+Lori%3BLynch%2C+Charles+F%3BMadeleine%2C+Margaret+M%3BPawlish%2C+Karen%3BRao%2C+Chandrika%3BWilliams%2C+Melanie+A%3BCastenson%2C+David%3BCurry%2C+Michael%3BParsons%2C+Ruth%3BFant%2C+Gregory%3BLin%2C+Monica&rft.aulast=Engels&rft.aufirst=Eric&rft.date=2011-11-02&rft.volume=306&rft.issue=17&rft.spage=1891&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2014-05-29 N1 - SubjectsTermNotLitGenreText - Thyroid; infection; Liver; Kidney; Standards; melanoma; Infection; Organs; Cancer; Melanoma; Lung cancer; USA ER - TY - JOUR T1 - Early-Life Exposures and Early-Onset Uterine Leiomyomata in Black Women in the Sister Study AN - 1008843703; 16537011 AB - Background: Uterine leiomyomata (fibroids) are hormonally responsive tumors, but little is known about risk factors. Early-life exposures may influence uterine development and subsequent response to hormones in adulthood. An earlier analysis of non-Hispanic white women who participated in the Sister Study found associations between several early-life factors and early-onset fibroids. Objectives: We evaluated associations of early-life and childhood exposures with early-onset fibroids among black women and compared the results with those found among white women. Methods: We analyzed baseline data from 3,534 black women, 35-59 years of age, in the Sister Study (a nationwide cohort of women who had a sister diagnosed with breast cancer) who self-reported information on early-life and childhood exposures. Early-onset fibroids were assessed based on self-report of a physician diagnosis of fibroids by the age of 30 years (n = 561). We estimated risk ratios (RR) and 95% confidence intervals (CI) from log-binomial regression models. Results: Factors most strongly associated with early-onset fibroids were in utero diethylstilbestrol (DES; RR = 2.02; 95% CI: 1.28, 3.18), maternal prepregnancy diabetes or gestational diabetes (RR = 1.54; 95% CI: 0.95, 2.49), and monozygotic multiple birth (RR = 1.94; 95% CI: 1.26, 2.99). We also found positive associations with having been taller or thinner than peers at the age of 10 years and with early-life factors that included being the firstborn child of a teenage mother, maternal hypertensive disorder, preterm birth, and having been fed soy formula. Conclusions: With the exception of monozygotic multiple birth and maternal hypertensive disorder, early-life risk factors for early-onset fibroids for black women were similar to those found for white women. However, in contrast to whites, childhood height and weight, but not low socioeconomic status indicators, were associated with early-onset fibroids in blacks. The general consistency of early-life findings for black and white women supports a possible role of early-life factors in fibroid development. JF - Environmental Health Perspectives AU - D'Aloisio, Aimee A AU - Baird, Donna D AU - DeRoo, Lisa A AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2011/11/02/ PY - 2011 DA - 2011 Nov 02 SP - 406 EP - 412 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 120 IS - 3 SN - 0091-6765, 0091-6765 KW - Toxicology Abstracts; Risk Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - diabetes mellitus KW - diethylstilbestrol KW - early-life KW - leiomyoma KW - multiple birth offspring KW - pregnancy KW - pregnancy-induced hypertension KW - prenatal exposure delayed effects KW - socioeconomic factors KW - soy formula KW - Age KW - tumors KW - Development KW - Hormones KW - Models KW - Risk factors KW - Regression analysis KW - Diethylstilbestrol KW - Adolescents KW - Uterus KW - Data processing KW - Tumors KW - Children KW - Cancer KW - Soybeans KW - Diabetes mellitus KW - Birth KW - Socio-economic aspects KW - Breast cancer KW - Females KW - X 24310:Pharmaceuticals KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1008843703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Early-Life+Exposures+and+Early-Onset+Uterine+Leiomyomata+in+Black+Women+in+the+Sister+Study&rft.au=D%27Aloisio%2C+Aimee+A%3BBaird%2C+Donna+D%3BDeRoo%2C+Lisa+A%3BSandler%2C+Dale+P&rft.aulast=D%27Aloisio&rft.aufirst=Aimee&rft.date=2011-11-02&rft.volume=120&rft.issue=3&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1103620 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Age; Uterus; Data processing; Development; Tumors; Children; Hormones; Soybeans; Models; Birth; Diabetes mellitus; Socio-economic aspects; Risk factors; Regression analysis; Breast cancer; Diethylstilbestrol; diabetes mellitus; tumors; Females; Cancer; Adolescents DO - http://dx.doi.org/10.1289/ehp.1103620 ER - TY - JOUR T1 - Optimal conditions for lentiviral transduction of engrafting human CD34 super(+) cells AN - 968168868; 16451699 AB - Cytokines are required for gamma -retroviral transduction of human CD34 super(+) cells. However, cytokines may reduce engraftment of CD34 super(+) cells and may not be necessary for their lentiviral transduction. We sought to optimize transduction and engraftment of human CD34 super(+) cells using lentiviral vectors. Single 24 h transduction of human CD34 super(+) cells with human immunodeficiency virus type 1 (HIV1)-based lentiviral vectors in media containing stem cell factor (SCF), FMS-like tyrosine kinase 3 (FLT3) ligand, thrombopoietin (each 100 ng ml super(-1)) and 10% fetal bovine serum was compared with various cytokine conditions during ex vivo culture and assayed using humanized xenograft mice for 6 months after transplantation. Serum-free media improved transduction efficiency of human CD34 super(+) cells. Interleukin-3 (20 ng ml super(-1)) had little effect on transduction efficiency or engraftment. Threefold higher cytokine mixture (each 300 ng ml super(-1)) reduced engraftment of CD34 super(+) cells. SCF alone (100 ng ml super(-1)) proved insufficient for maintaining engraftment ability and reduced transduction efficiency. Short-term prestimulation had little effect on transduction efficiency or engraftment, yet 24 h prestimulation showed higher transduction efficiency, higher gene expression levels and lower engraftment. In summary, 24 h prestimulation followed by single 24-h lentiviral transduction in serum-free media with SCF, FLT3 ligand and thrombopoietin yields high transduction efficiency to engrafting human CD34 super(+) cells, and is applicable in human clinical gene therapy trials. JF - Gene Therapy AU - Uchida, N AU - Hsieh, M M AU - Hayakawa, J AU - Madison, C AU - Washington, K N AU - Tisdale, J F AD - Molecular and Clinical Hematology Branch, National Heart Lung and Blood Institute (NHLBI)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD, USA Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1078 EP - 1086 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 18 IS - 11 SN - 0969-7128, 0969-7128 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - CD34 antigen KW - Cell culture KW - Clinical trials KW - Cytokines KW - FLT3L protein KW - Flt3 protein KW - Gene therapy KW - Interleukin 3 KW - Media (culture) KW - Stem cell factor KW - Thrombopoietin KW - Xenografts KW - Human immunodeficiency virus 1 KW - W 30905:Medical Applications KW - V 22360:AIDS and HIV KW - G 07760:Viruses & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968168868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Optimal+conditions+for+lentiviral+transduction+of+engrafting+human+CD34+super%28%2B%29+cells&rft.au=Uchida%2C+N%3BHsieh%2C+M+M%3BHayakawa%2C+J%3BMadison%2C+C%3BWashington%2C+K+N%3BTisdale%2C+J+F&rft.aulast=Uchida&rft.aufirst=N&rft.date=2011-11-01&rft.volume=18&rft.issue=11&rft.spage=1078&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2011.63 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2012-08-24 N1 - SubjectsTermNotLitGenreText - Gene therapy; Stem cell factor; Interleukin 3; Flt3 protein; FLT3L protein; Thrombopoietin; Cytokines; Cell culture; CD34 antigen; Xenografts; Clinical trials; Media (culture); Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1038/gt.2011.63 ER - TY - JOUR T1 - Clinical risk in paediatrics: Medicines AN - 964267926; 201206181 AB - The risk to children's health from medicines both prescribed and unprescribed is not insignificant and is probably greater than for adults. It arises from a long standing, and only recently rectified, lack of investment of research into the area of medicines for children, combined with the greater susceptibility of this age group to the effects of human error. This article explores some of the issues that contribute to this risk. Adapted from the source document. JF - Clinical Risk AU - Anderson, Mark AD - Consultant Paediatrician, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Trust, Queen Victoria Road, Newcastle upon Tyne, NEI 4LJ UK Mark.anderson7@nuth.nhs.uk Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 214 EP - 216 PB - Royal Society of Medicine Press Ltd, London UK VL - 17 IS - 6 SN - 1356-2622, 1356-2622 KW - Prescribed KW - Health KW - Children KW - Investment KW - Drugs KW - Susceptibility KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964267926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Risk&rft.atitle=Clinical+risk+in+paediatrics%3A+Medicines&rft.au=Anderson%2C+Mark&rft.aulast=Anderson&rft.aufirst=Mark&rft.date=2011-11-01&rft.volume=17&rft.issue=6&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Clinical+Risk&rft.issn=13562622&rft_id=info:doi/10.1258%2Fcr.2011.011044 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-04-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Drugs; Prescribed; Susceptibility; Investment; Children; Health DO - http://dx.doi.org/10.1258/cr.2011.011044 ER - TY - JOUR T1 - Serum total and HDL cholesterol and risk of prostate cancer AN - 926884750; 16351686 AB - Background: Studies suggest a decreased risk of high-grade prostate cancer in men with lower circulating total cholesterol and that statins may protect against aggressive disease. Confirmation in additional populations and examination of associations for lipoprotein subfractions are needed. Methods: We examined prostate cancer risk and serum total and HDL cholesterol in the ATBC Study cohort (n = 29,093). Cox proportional hazards models were used to estimate the relative risk of total (n = 2,041), non-aggressive (n = 829), aggressive (n = 461), advanced (n = 412), and high-grade (n = 231) prostate cancer by categories of total and HDL cholesterol. Results: After excluding the first 10 years of follow-up, men with higher serum total cholesterol were at increased risk of overall ( greater than or equal to 240 vs. <200 mg/dl: HR = 1.22, 95% CI 1.03-1.44, p-trend = 0 .01) and advanced ( greater than or equal to 240 vs. <200 mg/dl: HR = 1.85, 95% CI 1.13-3.03, p-trend = 0 .05) prostate cancer. Higher HDL cholesterol was suggestively associated with a decreased risk of prostate cancer regardless of stage or grade. Conclusions: In this population of smokers, high serum total cholesterol was associated with higher risk of advanced prostate cancer, and high HDL cholesterol suggestively reduced the risk of prostate cancer overall. These results support previous studies and, indirectly, support the hypothesis that statins may reduce the risk of advanced prostate cancer by lowering cholesterol. JF - Cancer Causes & Control AU - Mondul, Alison M AU - Weinstein, Stephanie J AU - Virtamo, Jarmo AU - Albanes, Demetrius AD - Department of Health and Human Services, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd. Ste. 320, Rockville, MD, 20852, USA, mondulam@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1545 EP - 1552 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 22 IS - 11 SN - 0957-5243, 0957-5243 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Cancer KW - Cholesterol KW - Prostate cancer KW - Risk reduction KW - Statins KW - cholesterol KW - prostate cancer KW - risk reduction KW - statins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926884750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Serum+total+and+HDL+cholesterol+and+risk+of+prostate+cancer&rft.au=Mondul%2C+Alison+M%3BWeinstein%2C+Stephanie+J%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius&rft.aulast=Mondul&rft.aufirst=Alison&rft.date=2011-11-01&rft.volume=22&rft.issue=11&rft.spage=1545&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9831-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - risk reduction; Statins; Prostate cancer; statins; Risk reduction; Cholesterol; prostate cancer; cholesterol; Cancer DO - http://dx.doi.org/10.1007/s10552-011-9831-7 ER - TY - JOUR T1 - LAURISTON S. TAYLOR LECTURE: RADIATION PROTECTION AND PUBLIC POLICY IN AN UNCERTAIN WORLD AN - 923208036; 16044257 AB - Ionizing radiation is a known, well-documented, and reasonably well-quantified human cancer risk factor based on a remarkably consistent body of dose-response information from epidemiological studies of exposed populations supported by experimental studies using animal and cellular models. This fact is largely ascribable to the relative ease, compared to other carcinogens, of estimating radiation dose to organs and local tissues. Statistical models for radiation-related cancer risk are increasingly relevant to both radiation protection policy and the adjudication of compensation claims for cancers diagnosed following occupational and environmental exposures to ionizing radiation, as discussed in a number of expert committee reports of national and international organizations concerned with radiation-related risks. These and other publications increasingly emphasize the relevance of well-quantified uncertainties in radiation-related risk projections, including upper and lower confidence or uncertainty bounds, for radiation protection. Finally, the wealth of detailed information provided by such quantitative uncertainty analysis approaches is highly relevant to radiation protection, which might be viewed as a political process that involves a diverse group of stakeholders who, individually, may be primarily concerned with avoiding possible radiation-related risks or with avoiding possibly unnecessary costs of risk reduction or unnecessary denial of benefits that require some radiation exposure, or with balancing both considerations to some degree. JF - Health Physics AU - Land, CE AD - Avenida de Saboia 914E, Apt. 4F, Monte Estoril 2765-579, Portugal, landc@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 499 EP - 508 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 101 IS - 5 SN - 0017-9078, 0017-9078 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Stakeholders KW - Politics KW - public policy KW - Risk reduction KW - Public policy KW - Organs KW - Cancer KW - risk reduction KW - Dose-response effects KW - Risk factors KW - Ionizing radiation KW - International organizations KW - international organizations KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/923208036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=LAURISTON+S.+TAYLOR+LECTURE%3A+RADIATION+PROTECTION+AND+PUBLIC+POLICY+IN+AN+UNCERTAIN+WORLD&rft.au=Land%2C+CE&rft.aulast=Land&rft.aufirst=CE&rft.date=2011-11-01&rft.volume=101&rft.issue=5&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0b013e318227e822 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Stakeholders; Politics; public policy; Risk reduction; Organs; Public policy; Cancer; risk reduction; Ionizing radiation; Risk factors; Dose-response effects; International organizations; international organizations DO - http://dx.doi.org/10.1097/HP.0b013e318227e822 ER - TY - JOUR T1 - Molecular differentiation of historic phage-type 80/81 and contemporary epidemic Staphylococcus aureus AN - 918060483; 16038754 AB - Staphylococcus aureus is a bacterial pathogen known to cause infections in epidemic waves. One such epidemic was caused by a clone known as phage-type 80/81, a penicillin-resistant strain that rose to world prominence in the late 1950s. The molecular underpinnings of the phage-type 80/81 outbreak have remained unknown for decades, nor is it understood why related S. aureus clones became epidemic in hospitals in the early 1990s. To better understand the molecular basis of these epidemics, we sequenced the genomes of eight S. aureus clinical isolates representative of the phage-type 80/81 clone, the Southwest Pacific clone [a community-associated methicillin-resistant S. aureus (MRSA) clone], and contemporary S. aureus clones, all of which are genetically related and belong to the same clonal complex (CC30). Genome sequence analysis revealed that there was coincident divergence of these clones from a recent common ancestor, a finding that resolves controversy about the evolutionary history of the lineage. Notably, we identified nonsynonymous SNPs in genes encoding accessory gene regulator C (agrC) and alpha -hemolysin (hla)-molecules important for S. aureus virulence-that were present in virtually all contemporary CC30 hospital isolates tested. Compared with the phage-type 80/81 and Southwest Pacific clones, contemporary CC30 hospital isolates had reduced virulence in mouse infection models, the result of SNPs in agrC and hla. We conclude that agr and hla (along with penicillin resistance) were essential for world dominance of phage-type 80/81 S. aureus, whereas key SNPs in contemporary CC30 clones restrict these pathogens to hospital settings in which the host is typically compromised. JF - Proceedings of the National Academy of Sciences, USA AU - DeLeo, Frank R AU - Kennedy, Adam D AU - Chen, Liang AU - Wardenburg, Juliane Bubeck AU - Kobayashi, Scott D AU - Mathema, Barun AU - Braughton, Kevin R AU - Whitney, Adeline R AU - Villaruz, Amer E AU - Martens, Craig A AU - Porcella, Stephen F AU - McGavin, Martin J AU - Otto, Michael AU - Musser, James M AU - Kreiswirth, Barry N AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840 Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 18091 EP - 18096 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 United States VL - 108 IS - 44 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology KW - Animal models KW - Clinical isolates KW - Differentiation KW - Dominance KW - Drug resistance KW - Epidemics KW - Evolution KW - Genomes KW - Histocompatibility antigen HLA KW - Hospitals KW - Infection KW - Nucleotide sequence KW - Pathogens KW - Penicillin KW - Single-nucleotide polymorphism KW - Virulence KW - Waves KW - Staphylococcus aureus KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918060483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Molecular+differentiation+of+historic+phage-type+80%2F81+and+contemporary+epidemic+Staphylococcus+aureus&rft.au=DeLeo%2C+Frank+R%3BKennedy%2C+Adam+D%3BChen%2C+Liang%3BWardenburg%2C+Juliane+Bubeck%3BKobayashi%2C+Scott+D%3BMathema%2C+Barun%3BBraughton%2C+Kevin+R%3BWhitney%2C+Adeline+R%3BVillaruz%2C+Amer+E%3BMartens%2C+Craig+A%3BPorcella%2C+Stephen+F%3BMcGavin%2C+Martin+J%3BOtto%2C+Michael%3BMusser%2C+James+M%3BKreiswirth%2C+Barry+N&rft.aulast=DeLeo&rft.aufirst=Frank&rft.date=2011-11-01&rft.volume=108&rft.issue=44&rft.spage=18091&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Genomes; Clinical isolates; Epidemics; Nucleotide sequence; Drug resistance; Animal models; Pathogens; Infection; Penicillin; Dominance; Virulence; Differentiation; Single-nucleotide polymorphism; Waves; Evolution; Hospitals; Staphylococcus aureus ER - TY - JOUR T1 - On the Pitfalls of Adjusting for Gestational Age at Birth AN - 918053278; 16099566 AB - Preterm delivery is a powerful predictor of newborn morbidity and mortality. Such problems are due to not only immaturity but also the pathologic factors (such as infection) that cause early delivery. The understanding of these underlying pathologic factors is incomplete at best. To the extent that unmeasured pathologies triggering preterm delivery also directly harm the fetus, they will confound the association of early delivery with neonatal outcomes. This, in turn, complicates studies of newborn outcomes more generally. When investigators analyze the association of risk factors with neonatal outcomes, adjustment for gestational age as a mediating variable will lead to bias. In the language of directed acyclic graphs, gestational age is a collider. The theoretical basis for colliders has been well described, and gestational age has recently been acknowledged as a possible collider. However, the impact of this problem, as well as its implications for perinatal research, has not been fully appreciated. The authors discuss the evidence for confounding and present simulations to explore how much bias is produced by adjustments for gestational age when estimating direct effects. Under plausible conditions, frank reversal of exposure-outcome associations can occur. When the purpose is causal inference, there are few settings in which adjustment for gestational age can be justified. JF - American Journal of Epidemiology AU - Wilcox, Allen J AU - Weinberg, Clarice R AU - Basso, Olga Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 1062 EP - 1068 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 174 IS - 9 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - Mortality KW - Age KW - Pathology KW - Risk factors KW - infection KW - Simulation KW - Neonates KW - Morbidity KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918053278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=On+the+Pitfalls+of+Adjusting+for+Gestational+Age+at+Birth&rft.au=Wilcox%2C+Allen+J%3BWeinberg%2C+Clarice+R%3BBasso%2C+Olga&rft.aulast=Wilcox&rft.aufirst=Allen&rft.date=2011-11-01&rft.volume=174&rft.issue=9&rft.spage=1062&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwr230 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - Mortality; Age; Pathology; Risk factors; infection; Simulation; Neonates; Morbidity DO - http://dx.doi.org/10.1093/aje/kwr230 ER - TY - JOUR T1 - Prospective Study of Alcohol Consumption Quantity and Frequency and Cancer-Specific Mortality in the US Population AN - 918053268; 16099564 AB - Prospective associations between quantity and frequency of alcohol consumption and cancer-specific mortality were studied using a nationally representative sample with pooled data from the 1988, 1990, 1991, and 1997-2004 administrations of the National Health Interview Survey (n = 323,354). By 2006, 8,362 participants had died of cancer. Cox proportional hazards regression was used to estimate relative risks. Among current alcohol drinkers, for all-site cancer mortality, higher-quantity drinking ( greater than or equal to 3 drinks on drinking days vs. 1 drink on drinking days) was associated with increased risk among men (relative risk (RR) = 1.24, 95% confidence interval (CI): 1.09, 1.41; P for linear trend = 0.001); higher-frequency drinking ( greater than or equal to 3 days/week vs. <1 day/week) was associated with increased risk among women (RR = 1.32, 95% CI: 1.13, 1.55; P-trend < 0.001). Lung cancer mortality results were similar, but among never smokers, results were null. For colorectal cancer mortality, higher-quantity drinking was associated with increased risk among women (RR = 1.93, 95% CI: 1.17, 3.18; P-trend = 0.03). Higher-frequency drinking was associated with increased risk of prostate cancer (RR = 1.55, 95% CI: 1.01, 2.38; P for quadratic effect = 0.03) and tended to be associated with increased risk of breast cancer (RR = 1.44, 95% CI: 0.96, 2.17; P-trend = 0.06). Epidemiologic studies of alcohol and cancer mortality should consider the independent effects of quantity and frequency. JF - American Journal of Epidemiology AU - Breslow, Rosalind A AU - Chen, Chiung M AU - Graubard, Barry I AU - Mukamal, Kenneth J Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 1044 EP - 1053 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 174 IS - 9 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Alcohol KW - USA KW - colorectal carcinoma KW - Breast cancer KW - prostate cancer KW - Lung cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918053268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Prospective+Study+of+Alcohol+Consumption+Quantity+and+Frequency+and+Cancer-Specific+Mortality+in+the+US+Population&rft.au=Breslow%2C+Rosalind+A%3BChen%2C+Chiung+M%3BGraubard%2C+Barry+I%3BMukamal%2C+Kenneth+J&rft.aulast=Breslow&rft.aufirst=Rosalind&rft.date=2011-11-01&rft.volume=174&rft.issue=9&rft.spage=1044&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwr210 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - Alcohol; Mortality; colorectal carcinoma; Breast cancer; prostate cancer; Lung cancer; USA DO - http://dx.doi.org/10.1093/aje/kwr210 ER - TY - JOUR T1 - AGA President's Symposium 2011: The Application of Genomics to Biodiversity AN - 918052373; 16141406 JF - Journal of Heredity AU - Johnson, Warren E AU - Hendrickson, Sher L AD - From the Laboratory of Genomic Diversity, National Cancer Institute, NCI-Frederick, Frederick, MD 21702, warjohns@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 782 EP - 783 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 102 IS - 6 SN - 0022-1503, 0022-1503 KW - Ecology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918052373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Heredity&rft.atitle=AGA+President%27s+Symposium+2011%3A+The+Application+of+Genomics+to+Biodiversity&rft.au=Johnson%2C+Warren+E%3BHendrickson%2C+Sher+L&rft.aulast=Johnson&rft.aufirst=Warren&rft.date=2011-11-01&rft.volume=102&rft.issue=6&rft.spage=782&rft.isbn=&rft.btitle=&rft.title=Journal+of+Heredity&rft.issn=00221503&rft_id=info:doi/10.1093%2Fjhered%2Fesr106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2014-04-17 DO - http://dx.doi.org/10.1093/jhered/esr106 ER - TY - JOUR T1 - Capsular polysaccharide vaccine for Group B Neisseria meningitidis, Escherichia coli K1, and Pasteurella haemolytica A2 AN - 918050651; 16038792 AB - We reviewed the literature that is the basis for our proposal that (2 arrow right 8)- alpha -Neu5Ac conjugates will be safe and effective vaccines for Group B meningococci (GBMs), Escherichia coli K1, and Pasteurella haemolytica A2. Although (2 arrow right 8)- alpha -Neu5Ac is a virulence factor and a protective antigen of these three pathogens, it is also a component of normal tissues (neural cell adhesion molecule). Natural, anti-(2 arrow right 8)- alpha -Neu5Ac present in most adults, vaccine-induced antibodies, and even high levels of spontaneously appearing monoclonal anti-(2 arrow right 8)- alpha -Neu5Ac did not cause autoimmunity. Although it is not possible to prove a null hypothesis, there are no epidemiologic, serologic, immunologic, or clinical data to indicate that (2 arrow right 8)- alpha -Neu5Ac antibodies will induce pathology or an autoimmune disease. No increased pathology caused by these antibodies was found, even in neonates and infants of mothers recovered from GBM meningitis. The lack of pathology mediated by anti-(2 arrow right 8)- alpha -Neu5Ac may be explained by different presentations of (2 arrow right 8)- alpha -Neu5Ac on bacterial and mammalian cells and by the unusual physicochemical properties of anti-(2 arrow right 8)- alpha -Neu5Ac. Based on clinical and experimental data collected over 30 y and because (2 arrow right 8)- alpha -Neu5Ac is an essential virulence factor and a protective antigen for GBM, E. coli K1, and P. haemolytica A2, protein conjugates of it are easy to prepare using inexpensive and plentiful ingredients, and they would be compatible with routinely administered infant vaccines, clinical studies of these conjugates should proceed. JF - Proceedings of the National Academy of Sciences, USA AU - Robbins, John B AU - Schneerson, Rachel AU - Xie, Guilin AU - Aake-Hanson, Lars AU - Miller, Mark A AD - Eunice Kennedy Shriver, National Institute of Child Health and Human Development, Bethesda, MD 20892 Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 17871 EP - 17875 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 United States VL - 108 IS - 44 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Antibodies KW - Autoimmune diseases KW - Capsular polysaccharides KW - Data processing KW - Infants KW - Mammalian cells KW - Meningitis KW - Neonates KW - Neural cell adhesion molecule KW - Pathogens KW - Physicochemical properties KW - Reviews KW - Vaccines KW - protective antigen KW - virulence factors KW - Neisseria meningitidis KW - Mannheimia haemolytica KW - Escherichia coli KW - F 06930:Autoimmunity KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918050651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Capsular+polysaccharide+vaccine+for+Group+B+Neisseria+meningitidis%2C+Escherichia+coli+K1%2C+and+Pasteurella+haemolytica+A2&rft.au=Robbins%2C+John+B%3BSchneerson%2C+Rachel%3BXie%2C+Guilin%3BAake-Hanson%2C+Lars%3BMiller%2C+Mark+A&rft.aulast=Robbins&rft.aufirst=John&rft.date=2011-11-01&rft.volume=108&rft.issue=44&rft.spage=17871&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Data processing; virulence factors; Autoimmune diseases; protective antigen; Physicochemical properties; Pathogens; Meningitis; Neural cell adhesion molecule; Antibodies; Mammalian cells; Reviews; Vaccines; Neonates; Capsular polysaccharides; Infants; Mannheimia haemolytica; Escherichia coli; Neisseria meningitidis ER - TY - JOUR T1 - Comparing cognitive interviewing and psychometric methods to evaluate a racial/ethnic discrimination scale AN - 916508562; 4260702 AB - Proponents of survey evaluation have long advocated the integration of qualitative and quantitative methodologies, but this recommendation has rarely been practiced. The authors used both methods to evaluate the "Everyday Discrimination" scale (EDS), which measures frequency of various types of discrimination, in a multiethnic population. Cognitive testing included 30 participants of various race/ethnic backgrounds and identified items that were redundant, unclear, or inconsistent (e.g., cognitive challenges in quantifying acts of discrimination). Psychometric analysis included secondary data from two national studies, including 570 Asian Americans, 366 Latinos, and 2,884 African Americans, and identified redundant items as well as those exhibiting differential item functioning (DIF) by race/ethnicity. Overall, qualitative and quantitative techniques complemented one another, as cognitive interviewing findings provided context and explanation for quantitative results. Researchers should consider further how to integrate these methods into instrument pretesting as a way to minimize response bias for ethnic and racial respondents in population-based surveys. Reprinted by permission of Sage Publications Inc. JF - Field methods AU - Reeve, Bryce B AU - Willis, Gordon AU - Shariff-Marco, Salma N AU - Breen, Nancy AU - Williams, David R AU - Gee, Gilbert C AU - Alegría, Margarita AU - Takeuchi, David T AU - Stapleton, Martha AU - Levin, Kerry Y AD - University of North Carolina, Chapel Hill ; National Institutes of Health, Bethesda ; Cancer Prevention Institute of California ; Harvard University ; University of California, Los Angeles ; University of Washington ; Westat Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 397 EP - 419 VL - 23 IS - 4 SN - 1525-822X, 1525-822X KW - Sociology KW - Evaluation KW - Comparative analysis KW - Racial discrimination KW - Ethnicity KW - Discrimination KW - African-Americans KW - U.S.A. KW - Psychometrics KW - Cognition KW - Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/916508562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Field+methods&rft.atitle=Comparing+cognitive+interviewing+and+psychometric+methods+to+evaluate+a+racial%2Fethnic+discrimination+scale&rft.au=Reeve%2C+Bryce+B%3BWillis%2C+Gordon%3BShariff-Marco%2C+Salma+N%3BBreen%2C+Nancy%3BWilliams%2C+David+R%3BGee%2C+Gilbert+C%3BAlegr%C3%ADa%2C+Margarita%3BTakeuchi%2C+David+T%3BStapleton%2C+Martha%3BLevin%2C+Kerry+Y&rft.aulast=Reeve&rft.aufirst=Bryce&rft.date=2011-11-01&rft.volume=23&rft.issue=4&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Field+methods&rft.issn=1525822X&rft_id=info:doi/10.1177%2F1525822X11416564 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3612 3549 2688 2449 10404; 10408 10404; 2449 10404; 2630 971; 7994; 4551; 4435; 10566 3612 3549 2688 2449 10404; 635 1656 10555 6091 961 636 4424; 433 293 14 DO - http://dx.doi.org/10.1177/1525822X11416564 ER - TY - JOUR T1 - Persistent distress after psychological exposure to the Nagasaki atomic bomb explosion AN - 914791144; 201200467 AB - Background: Although there is speculation that individuals living in the vicinity of nuclear disasters have persistent mental health deterioration due to psychological stress, few attempts have been made to examine this issue. Aims: To determine whether having been in the vicinity of the Nagasaki atomic bomb explosion in the absence of substantial exposure to radiation affected the mental health of local inhabitants more than half a century later. Method: Participants were randomly recruited from individuals who lived in the vicinity of the atomic bomb explosion in uncontaminated suburbs of Nagasaki. This sample (n = 347) was stratified by gender, age, perception of the explosion and current district of residence. Controls (n = 288) were recruited from among individuals who had moved into the area from outside Nagasaki 5-15 years after the bombing, matched for gender, age and district of residence. The primary outcome measure was the proportion of those at high risk of mental disorder based on the 28-item version of the General Health Questionnaire, with a cut-off point of 5/6. Other parameters related to individual perception of the explosion, health status, life events and habits were also assessed. Results: Having been in the vicinity of the explosion was the most significant factor (OR = 5.26, 95% CI 2.56-11.11) contributing to poorer mental health; erroneous knowledge of radiological hazard showed a mild association. In the sample group, anxiety after learning of the potential radiological hazard was significantly correlated with poor mental health (P<0.05), whereas anxiety about the explosion, or the degree of perception of it, was not; 74.5% of the sample group believed erroneously that the flash of the explosion was synonymous with radiation. Conclusions: Having been in the vicinity of the atomic bomb explosion without radiological exposure continued to be associated with poorer mental health more than half a century after the event. Fear on learning about the potential radiological hazard and lack of knowledge about radiological risk are responsible for this association. Adapted from the source document. JF - The British Journal of Psychiatry AU - Kim, Yoshiharu AU - Tsutsumi, Atsuro AU - Izutsu, Takashi AU - Kawamura, Noriyuki AU - Miyazaki, Takao AU - Kikkawa, Takehiko AD - Department of Adult Mental Health, National Institute of Mental Health, National Centre of Neurology and Psychiatry, 1-4-4 Ogawa Higashi Cho, Kodaira, Tokyo 187-8553, Japan kim@ncnp.go.jp Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 411 EP - 416 PB - Royal College of Psychiatrists, London UK VL - 199 IS - 5 SN - 0007-1250, 0007-1250 KW - Hazards KW - Learning KW - Gender KW - Mental health KW - Bombs KW - Explosions KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/914791144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+Journal+of+Psychiatry&rft.atitle=Persistent+distress+after+psychological+exposure+to+the+Nagasaki+atomic+bomb+explosion&rft.au=Kim%2C+Yoshiharu%3BTsutsumi%2C+Atsuro%3BIzutsu%2C+Takashi%3BKawamura%2C+Noriyuki%3BMiyazaki%2C+Takao%3BKikkawa%2C+Takehiko&rft.aulast=Kim&rft.aufirst=Yoshiharu&rft.date=2011-11-01&rft.volume=199&rft.issue=5&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Psychiatry&rft.issn=00071250&rft_id=info:doi/10.1192%2Fbjp.bp.110.085472 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-01-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BJPYAJ N1 - SubjectsTermNotLitGenreText - Explosions; Mental health; Bombs; Hazards; Gender; Learning DO - http://dx.doi.org/10.1192/bjp.bp.110.085472 ER - TY - JOUR T1 - Phase I trial of adoptive cell transfer with mixed-profile type-I/type-II allogeneic T cells for metastatic breast cancer. AN - 911925000; 21948234 AB - Metastatic breast cancer (MBC) response to allogeneic lymphocytes requires donor T-cell engraftment and is limited by graft-versus-host disease (GVHD). In mice, type-II-polarized T cells promote engraftment and modulate GVHD, whereas type-I-polarized T cells mediate more potent graft-versus-tumor (GVT) effects. This phase I translational study evaluated adoptive transfer of ex vivo costimulated type-I/type-II (T1/T2) donor T cells with T-cell-depleted (TCD) allogeneic stem cell transplantation (AlloSCT) for MBC. Patients had received anthracycline, taxane, and antibody therapies, and been treated for metastatic disease and a human leukocyte antigen (HLA)-identical-sibling donor. Donor lymphocytes were costimulated ex vivo with anti-CD3/anti-CD28 antibody-coated magnetic beads in interleukin (IL)-2/IL-4-supplemented media. Patients received reduced intensity conditioning, donor stem cells and T1/T2 cells, and monitoring for toxicity, engraftment, GVHD, and tumor response; results were compared with historical controls, identically treated except for T1/T2 product infusions. Mixed type-I/type-II CD4(+) T cells predominated in T1/T2 products. Nine patients received T1/T2 cells at dose level 1 (5 × 10(6) cells/kg). T-cell donor chimerism reached 100% by a median of 28 days. Seven (78%) developed acute GVHD. At day +28, five patients had partial responses (56%) and none had MBC progression; thereafter, two patients had continued responses. Donor T-cell engraftment and tumor responses appeared faster than in historical controls, but GVHD rates were similar and responders progressed early, often following treatment of acute GVHD. Allogeneic T1/T2 cells were safely infused with TCD-AlloSCT, appeared to promote donor engraftment, and may have contributed to transient early tumor responses. ©2011 AACR JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Hardy, Nancy M AU - Mossoba, Miriam E AU - Steinberg, Seth M AU - Fellowes, Vicki AU - Yan, Xiao-Yi AU - Hakim, Frances T AU - Babb, Rebecca R AU - Avila, Daniele AU - Gea-Banacloche, Juan AU - Sportès, Claude AU - Levine, Bruce L AU - June, Carl H AU - Khuu, Hahn M AU - Carpenter, Ashley E AU - Krumlauf, Michael C AU - Dwyer, Andrew J AU - Gress, Ronald E AU - Fowler, Daniel H AU - Bishop, Michael R AD - Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. hardyn@mail.nih.gov Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 6878 EP - 6887 VL - 17 IS - 21 SN - 1078-0432, 1078-0432 KW - Index Medicus KW - Graft vs Tumor Effect -- immunology KW - Humans KW - Adult KW - Neoplasm Metastasis KW - Middle Aged KW - Stem Cell Transplantation KW - Female KW - Breast Neoplasms -- immunology KW - Breast Neoplasms -- pathology KW - Breast Neoplasms -- therapy KW - Immunotherapy, Adoptive -- methods KW - Breast Neoplasms -- surgery KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911925000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Phase+I+trial+of+adoptive+cell+transfer+with+mixed-profile+type-I%2Ftype-II+allogeneic+T+cells+for+metastatic+breast+cancer.&rft.au=Hardy%2C+Nancy+M%3BMossoba%2C+Miriam+E%3BSteinberg%2C+Seth+M%3BFellowes%2C+Vicki%3BYan%2C+Xiao-Yi%3BHakim%2C+Frances+T%3BBabb%2C+Rebecca+R%3BAvila%2C+Daniele%3BGea-Banacloche%2C+Juan%3BSport%C3%A8s%2C+Claude%3BLevine%2C+Bruce+L%3BJune%2C+Carl+H%3BKhuu%2C+Hahn+M%3BCarpenter%2C+Ashley+E%3BKrumlauf%2C+Michael+C%3BDwyer%2C+Andrew+J%3BGress%2C+Ronald+E%3BFowler%2C+Daniel+H%3BBishop%2C+Michael+R&rft.aulast=Hardy&rft.aufirst=Nancy&rft.date=2011-11-01&rft.volume=17&rft.issue=21&rft.spage=6878&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-11-1579 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-20 N1 - Date created - 2011-11-02 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00082953; ClinicalTrials.gov N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] Cytotherapy. 2011 Jan;13(1):98-107 [20849361] Biol Blood Marrow Transplant. 2002;8(7):351-9 [12171481] Cytotherapy. 2002;4(5):429-30 [12473212] Blood. 2003 Nov 1;102(9):3439-46 [12855580] Cell. 2004 Apr 16;117(2):265-77 [15084263] Br J Haematol. 2004 Sep;126(6):837-43 [15352988] Blood. 2004 Oct 1;104(7):2187-93 [15172973] J Clin Oncol. 2004 Oct 1;22(19):3886-92 [15314059] Lancet. 1987 Jul 25;2(8552):175-8 [2885638] Ann Intern Med. 1988 Jun;108(6):806-14 [3285744] Bone Marrow Transplant. 1989 May;4(3):247-54 [2659110] Cancer Treat Res. 1990;50:99-111 [1976361] Blood. 1994 Nov 15;84(10):3540-9 [7949109] Bone Marrow Transplant. 1995 Jun;15(6):825-8 [7581076] Blood. 1996 Aug 15;88(4):1501-8 [8695872] J Immunol. 1996 Dec 1;157(11):4811-21 [8943383] Biol Blood Marrow Transplant. 1996 Oct;2(3):118-25 [9199754] J Clin Oncol. 1998 Mar;16(3):986-93 [9508181] Cytokines Cell Mol Ther. 1998 Mar;4(1):1-6 [9557210] Vox Sang. 1998;74 Suppl 2:331-40 [9704464] J Hematother. 1998 Oct;7(5):437-48 [9829318] Lancet. 2005 Jul 23-29;366(9482):318-20 [16039336] J Immunol. 2005 Nov 1;175(9):5732-43 [16237064] Biol Blood Marrow Transplant. 2005 Dec;11(12):945-56 [16338616] Blood. 2006 Feb 15;107(4):1325-31 [16269610] Annu Rev Immunol. 2006;24:147-74 [16551246] Clin Breast Cancer. 2006 Apr;7(1):87-9 [16764750] Blood. 2006 Jul 1;108(1):390-9 [16522809] Biol Blood Marrow Transplant. 2006 Sep;12(9):905-18 [16920556] Biol Blood Marrow Transplant. 2006 Nov;12(11):1150-60 [17085308] J Immunol. 2007 Apr 1;178(7):4222-9 [17371978] Biol Blood Marrow Transplant. 2007 Sep;13(9):1022-30 [17697964] Cancer. 2007 Sep 1;110(5):973-9 [17647245] J Immunol. 2008 Jan 1;180(1):89-105 [18097008] Bone Marrow Transplant. 2008 Mar;41(6):537-45 [18084340] Bone Marrow Transplant. 2009 Jul;44(2):81-7 [19448681] Immunol Cell Biol. 2010 Mar-Apr;88(3):250-6 [20065995] Curr Mol Med. 2010 Nov;10(8):719-26 [20937023] Leuk Lymphoma. 2000 Jul;38(3-4):221-34 [10830730] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/1078-0432.CCR-11-1579 ER - TY - JOUR T1 - Suppressed Type 1, Type 2, and Type 17 Cytokine Responses in Active Tuberculosis in Children AN - 911162780; 16062948 AB - Type 1 cytokine responses are known to play an important role in immunity to tuberculosis (TB) in children, although little is known about other factors that might be important. In addition, children are more prone to developing extrapulmonary manifestations of TB than adults. To identify the immune responses important both in control of infection and in extrapulmonary dissemination, we examined mycobacterium-specific cytokine responses of children with pulmonary TB (PTB) and extrapulmonary TB (ETB) and compared them with those of healthy control children (HC). No significant differences were found in the cytokine responses either with no stimulation or following mycobacterial-antigen (Ag) stimulation between children with PTB and ETB. On the other hand, children with active TB compared with HC showed markedly diminished production of type 1 (gamma interferon [IFN-] and tumor necrosis factor alpha [TNF-?]), 2 (interleukin 4 [IL-4] and IL-13), and 17 (IL-17A, IL-21, and IL-23)-associated cytokines with no stimulation and in response to mycobacterial antigens. This was not associated with significantly altered production of IL-10 or transforming growth factor ? (TGF-?). Among children with ETB, those with neurologic involvement exhibited more significantly diminished Ag-driven IFN- and IL-17 production. Pediatric TB is characterized by diminished type 1, 2, and 17 cytokine responses, with the most profound diminution favoring development of neurologic TB, suggesting a crucial role for these cytokines in protection against pediatric tuberculosis. JF - Clinical and Vaccine Immunology AU - Kumar, NPavan AU - Anuradha, R AU - Suresh, R AU - Ganesh, R AU - Shankar, Janani AU - Kumaraswami, V AU - Nutman, Thomas B AU - Babu, Subash AD - National Institutes of Health International Center for Excellence in Research, Chennai, India, sbabu@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1856 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 18 IS - 11 SN - 1556-679X, 1556-679X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Transforming growth factor KW - gamma -Interferon KW - Interleukin 4 KW - Mycobacterium KW - Pediatrics KW - Immunity KW - Infection KW - Children KW - Interleukin 21 KW - Interleukin 10 KW - Interferon KW - Interleukin 13 KW - Lung KW - Interleukin 17 KW - Cytokines KW - Tuberculosis KW - Immune response KW - Tumor necrosis factor- alpha KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911162780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Suppressed+Type+1%2C+Type+2%2C+and+Type+17+Cytokine+Responses+in+Active+Tuberculosis+in+Children&rft.au=Kumar%2C+NPavan%3BAnuradha%2C+R%3BSuresh%2C+R%3BGanesh%2C+R%3BShankar%2C+Janani%3BKumaraswami%2C+V%3BNutman%2C+Thomas+B%3BBabu%2C+Subash&rft.aulast=Kumar&rft.aufirst=NPavan&rft.date=2011-11-01&rft.volume=18&rft.issue=11&rft.spage=1856&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.05366-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Transforming growth factor; Interleukin 4; Pediatrics; Immunity; Interleukin 21; Children; Infection; Interleukin 10; Interferon; Interleukin 13; Lung; Interleukin 17; Cytokines; Tuberculosis; Tumor necrosis factor- alpha; Immune response; Mycobacterium DO - http://dx.doi.org/10.1128/CVI.05366-11 ER - TY - JOUR T1 - Pore water transport of enterococci out of beach sediments AN - 911154153; 15937003 AB - Enterococci are used to evaluate the safety of beach waters and studies have identified beach sands as a source of these bacteria. In order to study and quantify the release of microbes from beach sediments, flow column systems were built to evaluate flow of pore water out of beach sediments. Results show a peak in enterococci (average of 10% of the total microbes in core) released from the sand core within one pore water volume followed by a marked decline to below detection. These results indicate that few enterococci are easily removed and that factors other than simple pore water flow control the release of the majority of enterococci within beach sediments. A significantly larger quantity and release of enterococci were observed in cores collected after a significant rain event suggesting the influx of fresh water can alter the release pattern as compared to cores with no antecedent rainfall. JF - Marine Pollution Bulletin AU - Phillips, Matthew C AU - Solo-Gabriele, Helena M AU - Reniers, AJHM AU - Wang, John D AU - Kiger, Russell T AU - Abdel-Mottaleb, Noha AD - University of Miami, NSF NIEHS Oceans and Human Health Center, Miami, FL 33149, USA, hmsolo@miami.edu Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 2293 EP - 2298 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 62 IS - 11 SN - 0025-326X, 0025-326X KW - ASFA Marine Biotechnology Abstracts; Microbiology Abstracts B: Bacteriology; Environment Abstracts; Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Aqualine Abstracts; Water Resources Abstracts; Pollution Abstracts KW - Water Pollution KW - Pore water KW - Sediment gravity flows KW - Rainfall KW - Cores KW - Sand KW - Sediment Transport KW - Marine KW - Beaches KW - Freshwater environments KW - Interstitial Water KW - Sediments KW - Marine pollution KW - Rain KW - Flow Control KW - AQ 00001:Water Resources and Supplies KW - SW 3040:Wastewater treatment processes KW - Q4 27750:Environmental KW - O 4080:Pollution - Control and Prevention KW - P 1000:MARINE POLLUTION KW - Q5 08502:Methods and instruments KW - ENA 12:Oceans & Estuaries KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911154153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Pollution+Bulletin&rft.atitle=Pore+water+transport+of+enterococci+out+of+beach+sediments&rft.au=Phillips%2C+Matthew+C%3BSolo-Gabriele%2C+Helena+M%3BReniers%2C+AJHM%3BWang%2C+John+D%3BKiger%2C+Russell+T%3BAbdel-Mottaleb%2C+Noha&rft.aulast=Phillips&rft.aufirst=Matthew&rft.date=2011-11-01&rft.volume=62&rft.issue=11&rft.spage=2293&rft.isbn=&rft.btitle=&rft.title=Marine+Pollution+Bulletin&rft.issn=0025326X&rft_id=info:doi/10.1016%2Fj.marpolbul.2011.08.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2014-05-15 N1 - SubjectsTermNotLitGenreText - Pore water; Beaches; Sediment gravity flows; Marine pollution; Sediments; Freshwater environments; Sand; Rainfall; Rain; Sediment Transport; Water Pollution; Cores; Interstitial Water; Flow Control; Marine DO - http://dx.doi.org/10.1016/j.marpolbul.2011.08.049 ER - TY - JOUR T1 - 2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase AN - 904498597; 16000252 AB - Compared to normal differentiated cells, cancer cells have altered metabolic regulation to support biosynthesis and the expression of the M2 isozyme of pyruvate kinase (PKM2) plays an important role in this anabolic metabolism. While the M1 isoform is a highly active enzyme, the alternatively spliced M2 variant is considerably less active and expressed in tumors. While the exact mechanism by which decreased pyruvate kinase activity contributes to anabolic metabolism remains unclear, it is hypothesized that activation of PKM2 to levels seen with PKM1 may promote a metabolic program that is not conducive to cell proliferation. Here we report the third chemotype in a series of PKM2 activators based on the 2-oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamide scaffold. The synthesis, structure activity relationships, selectivity and notable physiochemical properties are described. JF - Bioorganic and Medicinal Chemistry Letters AU - Walsh, Martin J AU - Brimacombe, Kyle R AU - Veith, Henrike AU - Bougie, James M AU - Daniel, Thomas AU - Leister, William AU - Cantley, Lewis C AU - Israelsen, William J AU - Heiden, Matthew GVander AU - Shen, Min AU - Auld, Douglas S AU - Thomas, Craig J AU - Boxer, Matthew B AD - NIH Chemical Genomics Center, NIH Center for Translational Therapeutics, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA, boxerm@mail.nih.gov Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 6322 EP - 6327 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 21 IS - 21 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - Isoenzymes KW - Enzymes KW - Tumors KW - Cell proliferation KW - Tumor cells KW - Metabolism KW - Cancer KW - scaffolds KW - Pyruvate kinase KW - Alternative splicing KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904498597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=2-Oxo-N-aryl-1%2C2%2C3%2C4-tetrahydroquinoline-6-sulfonamides+as+activators+of+the+tumor+cell+specific+M2+isoform+of+pyruvate+kinase&rft.au=Walsh%2C+Martin+J%3BBrimacombe%2C+Kyle+R%3BVeith%2C+Henrike%3BBougie%2C+James+M%3BDaniel%2C+Thomas%3BLeister%2C+William%3BCantley%2C+Lewis+C%3BIsraelsen%2C+William+J%3BHeiden%2C+Matthew+GVander%3BShen%2C+Min%3BAuld%2C+Douglas+S%3BThomas%2C+Craig+J%3BBoxer%2C+Matthew+B&rft.aulast=Walsh&rft.aufirst=Martin&rft.date=2011-11-01&rft.volume=21&rft.issue=21&rft.spage=6322&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2011.08.114 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Isoenzymes; Enzymes; Tumors; Cell proliferation; Tumor cells; scaffolds; Cancer; Metabolism; Alternative splicing; Pyruvate kinase DO - http://dx.doi.org/10.1016/j.bmcl.2011.08.114 ER - TY - JOUR T1 - The effects of chronic treatment with mood stabilizers on the rat hippocampal post-synaptic density proteome. AN - 904222925; 21838781 AB - Bipolar disorder is a devastating illness that is marked by recurrent episodes of mania and depression. There is growing evidence that the disease is correlated with disruptions in synaptic plasticity cascades involved in cognition and mood regulation. Alleviating the symptoms of bipolar disorder involves chronic treatment with mood stabilizers like lithium or valproate. These two structurally dissimilar drugs are known to alter prominent signaling cascades in the hippocampus, but their effects on the post-synaptic density complex remain undefined. In this work, we utilized mass spectrometry for quantitative profiling of the rat hippocampal post-synaptic proteome to investigate the effects of chronic mood stabilizer treatment. Our data show that in response to chronic treatment of mood stabilizers there were not gross qualitative changes but rather subtle quantitative perturbations in post-synaptic density proteome linked to several key signaling pathways. Our data specifically support the changes in actin dynamics on valproate treatment. Using label-free quantification methods, we report that lithium and valproate significantly altered the abundance of 21 and 43 proteins, respectively. Seven proteins were affected similarly by both lithium and valproate: Ank3, glutamate receptor 3, dynein heavy chain 1, and four isoforms of the 14-3-3 family. Immunoblotting the same samples confirmed the changes in Ank3 and glutamate receptor 3 abundance. Our findings support the hypotheses that BPD is a synaptic disorder and that mood stabilizers modulate the protein signaling complex in the hippocampal post-synaptic density. Published 2011. This article is a US Government work and is in the public domain in the USA. JF - Journal of neurochemistry AU - Nanavati, Dhaval AU - Austin, Daniel R AU - Catapano, Lisa A AU - Luckenbaugh, David A AU - Dosemeci, Ayse AU - Manji, Husseini K AU - Chen, Guang AU - Markey, Sanford P AD - Laboratory of Neurotoxicology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-1262, USA. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 617 EP - 629 VL - 119 IS - 3 KW - Antipsychotic Agents KW - 0 KW - Proteome KW - Valproic Acid KW - 614OI1Z5WI KW - Lithium KW - 9FN79X2M3F KW - Index Medicus KW - Rats KW - Animals KW - Drug Administration Schedule KW - Rats, Inbred WKY KW - Gene Regulatory Networks -- drug effects KW - Treatment Outcome KW - Mood Disorders -- drug therapy KW - Gene Regulatory Networks -- physiology KW - Male KW - Proteome -- genetics KW - Post-Synaptic Density -- drug effects KW - Antipsychotic Agents -- administration & dosage KW - Proteome -- drug effects KW - Post-Synaptic Density -- genetics KW - Lithium -- administration & dosage KW - Hippocampus -- metabolism KW - Proteome -- metabolism KW - Valproic Acid -- administration & dosage KW - Post-Synaptic Density -- metabolism KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904222925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=The+effects+of+chronic+treatment+with+mood+stabilizers+on+the+rat+hippocampal+post-synaptic+density+proteome.&rft.au=Nanavati%2C+Dhaval%3BAustin%2C+Daniel+R%3BCatapano%2C+Lisa+A%3BLuckenbaugh%2C+David+A%3BDosemeci%2C+Ayse%3BManji%2C+Husseini+K%3BChen%2C+Guang%3BMarkey%2C+Sanford+P&rft.aulast=Nanavati&rft.aufirst=Dhaval&rft.date=2011-11-01&rft.volume=119&rft.issue=3&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=1471-4159&rft_id=info:doi/10.1111%2Fj.1471-4159.2011.07424.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-29 N1 - Date created - 2011-10-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Psychiatry. 2000 Mar;5(2):142-9 [10822341] J Neurochem. 2000 Oct;75(4):1729-34 [10987856] Eur J Pharmacol. 2000 Jul 21;400(2-3):221-4 [10988337] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4746-51 [11296301] J Biol Chem. 2001 Sep 28;276(39):36734-41 [11473107] Neuroreport. 2001 Oct 29;12(15):3257-62 [11711867] EMBO J. 2001 Dec 17;20(24):6969-78 [11742974] Neuron. 2002 Apr 25;34(3):411-23 [11988172] J Neurosci. 2002 Jun 1;22(11):4264-73 [12040031] Arch Gen Psychiatry. 2002 Jul;59(7):631-40 [12090816] Proteomics. 2003 Jan;3(1):19-28 [12548630] Mol Cell Neurosci. 2003 Jan;22(1):62-74 [12595239] Neuron. 2003 Apr 24;38(2):157-60 [12718851] Nat Neurosci. 2004 Apr;7(4):357-63 [15034585] Proc Natl Acad Sci U S A. 2004 May 4;101(18):7187-92 [15107502] Mol Psychiatry. 2004 Jun;9(6):609-20, 544 [14708030] J Proteome Res. 2004 Sep-Oct;3(5):1002-8 [15473689] Am J Psychiatry. 2004 Nov;161(11):1957-66 [15514393] J Cell Biol. 1980 Sep;86(3):831-45 [7410481] J Pharmacol Exp Ther. 1999 Oct;291(1):161-70 [10490900] Biol Psychiatry. 2004 Dec 15;56(12):943-50 [15601604] J Cell Biol. 2005 Jan 17;168(2):329-38 [15657400] Cell Res. 2005 Feb;15(2):83-91 [15740635] Neuropsychopharmacology. 2005 May;30(5):974-83 [15726117] J Biol Chem. 2005 May 27;280(21):20503-8 [15790563] Hum Mol Genet. 2005 Jul 1;14(13):1863-76 [15888475] Am J Psychiatry. 2005 Jul;162(7):1256-65 [15994707] Am J Hum Genet. 2005 Nov;77(5):685-93 [16252231] Nat Neurosci. 2005 Nov;8(11):1525-33 [16222232] Mol Cell Biol. 2005 Nov;25(22):9920-35 [16260607] J Biol Chem. 2005 Dec 23;280(51):41805-10 [16221686] Am J Hum Genet. 2005 Dec;77(6):918-36 [16380905] Hum Mol Genet. 2006 Mar 1;15(5):691-703 [16434483] NeuroRx. 2005 Oct;2(4):671-82 [16489374] Hum Mol Genet. 2006 Mar 15;15(6):965-77 [16467349] J Alzheimers Dis. 2005 Mar;8(4):377-86 [16556969] J Neurochem. 2006 Apr;97 Suppl 1:16-23 [16635246] Mol Cell Proteomics. 2006 May;5(5):914-22 [16452087] Bipolar Disord. 2006 Jun;8(3):255-64 [16696827] Biol Psychiatry. 2006 Jun 1;59(11):1006-20 [16487491] Amino Acids. 2006 Jun;30(4):477-93 [16583313] Lancet Neurol. 2006 Nov;5(11):911-6 [17052657] Mol Psychiatry. 2007 Jan;12(1):74-86 [17043677] Psychiatry Clin Neurosci. 2007 Feb;61(1):3-19 [17239033] Lancet Neurol. 2007 Apr;6(4):322-8 [17362836] Neuroscience. 2007 Apr 14;145(4):1233-48 [17303344] Nature. 2007 Jun 7;447(7145):661-78 [17554300] Annu Rev Biochem. 2007;76:823-47 [17243894] EMBO J. 2007 Jun 20;26(12):2991-3002 [17541406] J Biol Chem. 2007 Jul 6;282(27):19884-93 [17439943] Genes Dev. 2007 Sep 15;21(18):2347-57 [17875668] Mol Cell Proteomics. 2007 Oct;6(10):1749-60 [17623647] J Biol Chem. 2007 Oct 19;282(42):30523-34 [17761673] Psychopharmacology (Berl). 2007 Dec;195(3):357-67 [17705060] Neuropsychopharmacology. 2008 Jan;33(2):361-7 [17406649] Arch Neurol. 2008 Jan;65(1):45-53 [17998437] Invest Ophthalmol Vis Sci. 2008 Feb;49(2):788-99 [18235029] Nat Neurosci. 2008 Jul;11(7):799-806 [18536710] J Proteomics. 2008 Aug 21;71(3):346-56 [18639657] J Neural Transm (Vienna). 2008 Sep;115(9):1355-65 [18665322] Hum Mol Genet. 2008 Oct 15;17(20):3212-22 [18658164] Mol Cell Proteomics. 2008 Nov;7(11):2123-37 [18614564] Neoplasia. 2009 Jan;11(1):77-86, 4p following 86 [19107234] J Neural Transm (Vienna). 2009 Mar;116(3):275-89 [19034380] Ann Med. 2009;41(3):177-85 [18932104] Mol Psychiatry. 2009 May;14(5):487-91 [19088739] Am J Pathol. 2009 Jul;175(1):17-24 [19497998] Neuron. 2009 Sep 10;63(5):628-42 [19755106] Am J Med Genet B Neuropsychiatr Genet. 2009 Oct 5;150B(7):977-83 [19160447] Dialogues Clin Neurosci. 2009;11(3):333-48 [19877500] J Neurosci. 2009 Nov 4;29(44):14039-49 [19890013] Mol Cell Neurosci. 2009 Dec;42(4):466-83 [19796685] Mol Cell Neurosci. 2009 Dec;42(4):448-57 [19796686] Neuron. 2010 Feb 25;65(4):445-59 [20188650] Proteomics. 2010 Aug;10(16):3035-9 [20564260] J Neurophysiol. 2010 Apr;103(4):1758-70 [20107120] Electrophoresis. 1999 Dec;20(18):3551-67 [10612281] J Biol Chem. 2000 Feb 4;275(5):3247-55 [10652311] Curr Opin Cell Biol. 2000 Feb;12(1):97-103 [10679358] J Neurosci. 2000 May 1;20(9):3076-84 [10777771] Hum Mol Genet. 2000 May 22;9(9):1259-71 [10814708] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1471-4159.2011.07424.x ER - TY - JOUR T1 - super(68)Ga-DOTA-Affibody molecule for in vivo assessment of HER2/neu expression with PET AN - 902348494; 15845818 AB - Purpose: Overexpression of HER2/neu in breast cancer is correlated with a poor prognosis. It may vary between primary tumors and metastatic lesions and change during the treatment. Therefore, there is a need for a new means to assess HER2/neu expression in vivo. In this work, we used super(68)Ga-labeled DOTA-Z sub(HER2:2891)-Affibody to monitor HER2/neu expression in a panel of breast cancer xenografts. Methods: DOTA-Z sub(HER2:2891)-Affibody molecules were labeled with super(68)Ga. In vitro binding was characterized by a receptor saturation assay. Biodistribution and PET imaging studies were conducted in athymic nude mice bearing subcutaneous human breast cancer tumors with three different levels of HER2/neu expression. Nonspecific uptake was analyzed using non-HER2-specific Affibody molecules. Signal detected by PET was compared with ex vivo assessment of the tracer uptake and HER2/neu expression. Results: The super(68)Ga-DOTA-Z sub(HER2:2891)-Affibody probe showed high binding affinity to MDA-MB-361 cells (K sub(D)=1.4+/-0.19 nM). In vivo biodistribution and PET imaging studies demonstrated high radioactivity uptake in HER2/neu-positive tumors. Tracer was eliminated quickly from the blood and normal tissues, resulting in high tumor-to-blood ratios. The highest concentration of radioactivity in normal tissue was seen in the kidneys (227+/-14%ID/g). High-contrast PET images of HER2/neu-overexpressing tumors were recorded as soon as 1 h after tracer injection. A good correlation was observed between PET imaging, biodistribution estimates of tumor tracer concentration, and the receptor expression. Conclusion: These results suggest that PET imaging using super(68)Ga-DOTA-Z sub(HER2:2891)-Affibody is sensitive enough to detect different levels of HER2/neu expression in vivo. JF - European Journal of Nuclear Medicine and Molecular Imaging AU - Kramer-Marek, Gabriela AU - Shenoy, Nalini AU - Seidel, Jurgen AU - Griffiths, Gary L AU - Choyke, Peter AU - Capala, Jacek AD - National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA, capalaj@mail.nih.gov capalaj@mail.nih.gov capalaj@mail.nih.gov capalaj@mail.nih.gov capalaj@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1967 EP - 1976 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 38 IS - 11 SN - 1619-7070, 1619-7070 KW - Biotechnology and Bioengineering Abstracts KW - ErbB-2 protein KW - Probes KW - Prognosis KW - Tumors KW - Metastases KW - Tracers KW - Blood KW - Kidney KW - Breast cancer KW - Nuclear medicine KW - Radioactivity KW - Xenografts KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902348494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.atitle=super%2868%29Ga-DOTA-Affibody+molecule+for+in+vivo+assessment+of+HER2%2Fneu+expression+with+PET&rft.au=Kramer-Marek%2C+Gabriela%3BShenoy%2C+Nalini%3BSeidel%2C+Jurgen%3BGriffiths%2C+Gary+L%3BChoyke%2C+Peter%3BCapala%2C+Jacek&rft.aulast=Kramer-Marek&rft.aufirst=Gabriela&rft.date=2011-11-01&rft.volume=38&rft.issue=11&rft.spage=1967&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.issn=16197070&rft_id=info:doi/10.1007%2Fs00259-011-1810-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Metastases; Blood; Tracers; ErbB-2 protein; Prognosis; Probes; Kidney; Nuclear medicine; Breast cancer; Xenografts; Radioactivity; Tumors DO - http://dx.doi.org/10.1007/s00259-011-1810-4 ER - TY - JOUR T1 - Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer. AN - 902329191; 22027685 AB - Smoking is the leading cause of preventable cancer deaths in the United States. Nicotine replacement therapies (NRT) have been developed to aid in smoking cessation, which decreases lung cancer incidence. However, the safety of NRT is controversial because numerous preclinical studies have shown that nicotine enhances tumor cell growth in vitro and in vivo. We modeled NRT in mice to determine the effects of physiologic levels of nicotine on lung tumor formation, tumor growth, or metastasis. Nicotine administered in drinking water did not enhance lung tumorigenesis after treatment with the tobacco carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Tumors that develop in this model have mutations in K-ras, which is commonly observed in smoking-related, human lung adenocarcinomas. In a transgenic model of mutant K-ras-driven lung cancer, nicotine did not increase tumor number or size and did not affect overall survival. Likewise, in a syngeneic model using lung cancer cell lines derived from NNK-treated mice, oral nicotine did not enhance tumor growth or metastasis. These data show that nicotine does not enhance lung tumorigenesis when given to achieve levels comparable with those of NRT, suggesting that nicotine has a dose threshold, below which it has no appreciable effect. These studies are consistent with epidemiologic data showing that NRT does not enhance lung cancer risk in former smokers. JF - Cancer prevention research (Philadelphia, Pa.) AU - Maier, Colleen R AU - Hollander, M Christine AU - Hobbs, Evthokia A AU - Dogan, Irem AU - Linnoila, R Ilona AU - Dennis, Phillip A AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 1743 EP - 1751 VL - 4 IS - 11 KW - Carcinogens KW - 0 KW - Drinking Water KW - Nitrosamines KW - Nicotine KW - 6M3C89ZY6R KW - 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone KW - 7S395EDO61 KW - Kras2 protein, mouse KW - EC 3.6.5.2 KW - Proto-Oncogene Proteins p21(ras) KW - Index Medicus KW - Nitrosamines -- toxicity KW - Mice, Inbred A KW - Animals KW - Cells, Cultured KW - Humans KW - Mice, Inbred C57BL KW - Carcinogens -- toxicity KW - Mice KW - Male KW - Female KW - Lung Neoplasms -- etiology KW - Cell Transformation, Neoplastic -- pathology KW - Adenocarcinoma -- etiology KW - Lung Neoplasms -- drug therapy KW - Nicotine -- administration & dosage KW - Mutation -- genetics KW - Disease Models, Animal KW - Adenocarcinoma -- drug therapy KW - Proto-Oncogene Proteins p21(ras) -- genetics KW - Lung Neoplasms -- pathology KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902329191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.atitle=Nicotine+does+not+enhance+tumorigenesis+in+mutant+K-ras-driven+mouse+models+of+lung+cancer.&rft.au=Maier%2C+Colleen+R%3BHollander%2C+M+Christine%3BHobbs%2C+Evthokia+A%3BDogan%2C+Irem%3BLinnoila%2C+R+Ilona%3BDennis%2C+Phillip+A&rft.aulast=Maier&rft.aufirst=Colleen&rft.date=2011-11-01&rft.volume=4&rft.issue=11&rft.spage=1743&rft.isbn=&rft.btitle=&rft.title=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.issn=1940-6215&rft_id=info:doi/10.1158%2F1940-6207.CAPR-11-0365 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-12 N1 - Date created - 2011-11-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 2005 Jan 17;92(1):131-9 [15597105] Oncogene. 2011 Apr 14;30(15):1812-21 [21242979] Int J Epidemiol. 2000 Dec;29(6):963-8 [11101535] Nature. 2001 Apr 26;410(6832):1111-6 [11323676] Cancer Res. 2001 May 15;61(10):3986-97 [11358816] Nat Med. 2001 Jul;7(7):833-9 [11433349] Genes Dev. 2001 Dec 15;15(24):3243-8 [11751630] J Clin Invest. 2003 Jan;111(1):81-90 [12511591] IARC Sci Publ. 1978;(19):395-413 [680735] Cancer Res. 1989 Jul 15;49(14):3770-5 [2736518] Cancer Res. 1991 Oct 15;51(20):5557-64 [1913675] Cancer Res. 1992 Jun 1;52(11):3164-73 [1591728] Int J Cancer. 1993 Jan 21;53(2):250-6 [8425762] Clin Pharmacol Ther. 1993 Jul;54(1):98-106 [8330471] JAMA. 1995 Nov 1;274(17):1353-8 [7563559] Psychopharmacology (Berl). 1996 Apr;124(4):332-9 [8739548] Anticancer Res. 1996 Nov-Dec;16(6B):3615-9 [9042230] Carcinogenesis. 1998 Aug;19(8):1503-8 [9744549] Carcinogenesis. 1999 Aug;20(8):1577-82 [10426810] Cancer Prev Res (Phila). 2011 Nov;4(11):1752-60 [22027684] J Biol Chem. 2005 Feb 25;280(8):6369-79 [15574422] Int J Oncol. 2006 Feb;28(2):337-44 [16391787] DNA Cell Biol. 2006 May;25(5):312-22 [16716121] Clin Cancer Res. 2007 Apr 1;13(7):2281-9 [17404113] Nat Protoc. 2006;1(3):1112-6 [17406391] Mutat Res. 2008 Sep-Oct;659(3):221-31 [18495523] Int J Cancer. 2009 Jan 1;124(1):36-45 [18844224] Annu Rev Pharmacol Toxicol. 2009;49:57-71 [18834313] PLoS One. 2009;4(3):e5061 [19330036] Cell. 2009 May 29;137(5):835-48 [19490893] Nicotine Tob Res. 2009 Sep;11(9):1076-82 [19571249] PLoS One. 2009;4(10):e7524 [19841737] J Cell Biochem. 2010 Jan 1;109(1):152-61 [19911375] Cancer. 2010 Feb 1;116(3):544-73 [19998273] Am J Rhinol Allergy. 2010 Mar-Apr;24(2):e73-7 [20338106] Toxicol Sci. 2010 May;115(1):118-30 [20106947] Cancer Prev Res (Phila). 2010 Sep;3(9):1066-76 [20810672] J Pharmacol Exp Ther. 2010 Dec;335(3):553-61 [20843956] Comment In: Cancer Prev Res (Phila). 2011 Nov;4(11):1719-23 [22052338] Cancer Prev Res (Phila). 2011 Nov;4(11):1724-7 [22052339] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1940-6207.CAPR-11-0365 ER - TY - JOUR T1 - A phase I study of PF-04929113 (SNX-5422), an orally bioavailable heat shock protein 90 inhibitor, in patients with refractory solid tumor malignancies and lymphomas. AN - 902086157; 21908572 AB - To determine the maximum tolerated dose (MTD), toxicities, and pharmacokinetic/pharmacodynamic profile of the Hsp90 inhibitor PF-04929113 (SNX-5422) in patients with advanced solid tumors and lymphomas. This was a single-institution, phase I, dose-escalation study of PF-04929113 administered twice weekly. Endpoints included determination of dose-limiting toxicities (DLT), MTD, the safety profile of PF-04929113, pharmacodynamic assessment of PF-04929113 on Hsp70 induction, pharmacokinetic analysis of PF-04928473 (SNX-2112) and its prodrug PF-04929113, and assessment of response. Thirty-three patients with advanced malignancies were treated. Dose escalation was continued up to 177 mg/m(2) administered orally twice a week. One DLT (nonseptic arthritis) was noted. No grade 4 drug-related adverse events were seen; grade 3 adverse events included diarrhea (9%), nonseptic arthritis (3%), aspartate aminotransferase elevation (3%), and thrombocytopenia (3%). No objective responses were seen in 32 evaluable patients. Fifteen patients (47%) had stable disease; 17 patients (53%) had progressive disease. Pharmacokinetic data revealed rapid absorption, hepatic, and extrahepatic clearance, extensive tissue binding, and almost linear pharmacokinetics of the active drug PF-04928473. Pharmacodynamic studies confirmed inhibition of Hsp90 and a linear correlation between pharmacokinetic parameters and Hsp70 induction. PF-04929113 administered orally twice a week is well tolerated and inhibits its intended target Hsp90. No objective responses were seen, but long-lasting stabilizations were obtained. Although no clinically significant drug-related ocular toxicity was seen in this study, the development of PF-04929113 has been discontinued because of ocular toxicity seen in animal models and in a separate phase I study. ©2011 AACR JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Rajan, Arun AU - Kelly, Ronan J AU - Trepel, Jane B AU - Kim, Yeong Sang AU - Alarcon, Sylvia V AU - Kummar, Shivaani AU - Gutierrez, Martin AU - Crandon, Sonja AU - Zein, Wadih M AU - Jain, Lokesh AU - Mannargudi, Baskar AU - Figg, William D AU - Houk, Brett E AU - Shnaidman, Michael AU - Brega, Nicoletta AU - Giaccone, Giuseppe AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 6831 EP - 6839 VL - 17 IS - 21 SN - 1078-0432, 1078-0432 KW - Benzamides KW - 0 KW - HSP90 Heat-Shock Proteins KW - Indazoles KW - PF 04929113 KW - Index Medicus KW - Drug Administration Schedule KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Neoplasms -- drug therapy KW - Benzamides -- adverse effects KW - Benzamides -- pharmacokinetics KW - Neoplasms -- blood KW - HSP90 Heat-Shock Proteins -- blood KW - Indazoles -- administration & dosage KW - Indazoles -- adverse effects KW - Indazoles -- pharmacokinetics KW - Lymphoma -- blood KW - Lymphoma -- drug therapy KW - HSP90 Heat-Shock Proteins -- antagonists & inhibitors KW - Benzamides -- administration & dosage KW - Lymphoma -- metabolism KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902086157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=A+phase+I+study+of+PF-04929113+%28SNX-5422%29%2C+an+orally+bioavailable+heat+shock+protein+90+inhibitor%2C+in+patients+with+refractory+solid+tumor+malignancies+and+lymphomas.&rft.au=Rajan%2C+Arun%3BKelly%2C+Ronan+J%3BTrepel%2C+Jane+B%3BKim%2C+Yeong+Sang%3BAlarcon%2C+Sylvia+V%3BKummar%2C+Shivaani%3BGutierrez%2C+Martin%3BCrandon%2C+Sonja%3BZein%2C+Wadih+M%3BJain%2C+Lokesh%3BMannargudi%2C+Baskar%3BFigg%2C+William+D%3BHouk%2C+Brett+E%3BShnaidman%2C+Michael%3BBrega%2C+Nicoletta%3BGiaccone%2C+Giuseppe&rft.aulast=Rajan&rft.aufirst=Arun&rft.date=2011-11-01&rft.volume=17&rft.issue=21&rft.spage=6831&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-11-0821 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-20 N1 - Date created - 2011-11-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 1999 Apr;17(4):1244 [10561185] J Thorac Oncol. 2008 Jun;3(6 Suppl 2):S152-9 [18520302] Exp Biol Med (Maywood). 2003 Feb;228(2):111-33 [12563018] Nature. 2003 Sep 25;425(6956):407-10 [14508491] J Clin Oncol. 2005 Mar 20;23(9):1885-93 [15774780] J Biol Chem. 2008 Jul 4;283(27):18473-7 [18442971] Cancer Res. 2008 Jul 15;68(14):5827-38 [18632637] Blood. 2009 Jan 22;113(4):846-55 [18948577] Mol Cell. 2009 Oct 9;36(1):15-27 [19818706] Mol Cell. 2009 Oct 23;36(2):176-7 [19854128] Oncol Res. 2009;18(5-6):229-42 [20225761] Nat Rev Mol Cell Biol. 2010 Jul;11(7):515-28 [20531426] Exp Eye Res. 2010 Aug;91(2):211-9 [20493187] Nat Rev Cancer. 2010 Aug;10(8):537-49 [20651736] J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Nov 15;878(30):3187-92 [20951100] J Clin Oncol. 2010 Nov 20;28(33):4953-60 [20940188] Br J Haematol. 2011 Feb;152(4):367-79 [21219297] J Clin Oncol. 2005 Jun 20;23(18):4152-61 [15961763] Clin Cancer Res. 2007 Mar 15;13(6):1625-9 [17363512] Clin Cancer Res. 2007 Mar 15;13(6):1769-74 [17363531] Clin Cancer Res. 2007 Mar 15;13(6):1775-82 [17363532] Br J Cancer. 2007 Sep 17;97(6):741-4 [17712310] Cell. 2007 Sep 21;130(6):1005-18 [17889646] Clin Cancer Res. 2008 Jan 1;14(1):240-8 [18172276] J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-11-0821 ER - TY - JOUR T1 - AMPA induced Ca2+ influx in motor neurons occurs through voltage gated Ca2+ channel and Ca2+ permeable AMPA receptor. AN - 901644317; 21777635 AB - The rise in intracellular Ca(2+) mediated by AMPA subtype of glutamate receptors has been implicated in the pathogenesis of motor neuron disease, but the exact route of Ca(2+) entry into motor neurons is not clearly known. In the present study, we examined the role of voltage gated calcium channels (VGCCs) in AMPA induced Ca(2+) influx and subsequent intracellular signaling events responsible for motor neuron degeneration. AMPA stimulation caused sodium influx in spinal neurons that would depolarize the plasma membrane. The AMPA induced [Ca(2+)](i) rise in motor neurons as well as other spinal neurons was drastically reduced when extracellular sodium was replaced with NMDG, suggesting the involvement of voltage gated calcium channels. AMPA mediated rise in [Ca(2+)](i) was significantly inhibited by L-type VGCC blocker nifedipine, whereas ω-agatoxin-IVA and ω-conotoxin-GVIA, specific blockers of P/Q type and N-type VGCC were not effective. 1-Napthyl-acetyl spermine (NAS), an antagonist of Ca(2+) permeable AMPA receptors partially inhibited the AMPA induced [Ca(2+)](i) rise but selectively in motor neurons. Measurement of AMPA induced currents in whole cell voltage clamp mode suggests that a moderate amount of Ca(2+) influx occurs through Ca(2+) permeable AMPA receptors in a subpopulation of motor neurons. The AMPA induced mitochondrial calcium loading [Ca(2+)](m), mitochondrial depolarization and neurotoxicity were also significantly reduced in presence of nifedipine. Activation of VGCCs by depolarizing concentration of KCl (30mM) in extracellular medium increased the [Ca(2+)](i) but no change was observed in mitochondrial Ca(2+) and membrane potential. Our results demonstrate that a subpopulation of motor neurons express Ca(2+) permeable AMPA receptors, however the larger part of Ca(2+) influx occurs through L-type VGCCs subsequent to AMPA receptor activation and consequent mitochondrial dysfunction is the trigger for motor neuron degeneration. Nifedipine is an effective protective agent against AMPA induced mitochondrial stress and degeneration of motor neurons. Copyright © 2011 Elsevier B.V. All rights reserved. JF - Neurochemistry international AU - Joshi, Dinesh C AU - Singh, Mahendra AU - Krishnamurthy, Karthik AU - Joshi, Preeti G AU - Joshi, Nanda B AD - Department of Biophysics, National Institute of Mental Health and Neuro Sciences, Bangalore 560 029, India. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 913 EP - 921 VL - 59 IS - 6 KW - Calcium Channels KW - 0 KW - Calcium Channels, L-Type KW - Receptors, AMPA KW - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid KW - 77521-29-0 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Calcium Channels, L-Type -- physiology KW - Primary Cell Culture KW - Motor Neurons -- metabolism KW - Calcium Channels -- physiology KW - Cell Membrane Permeability -- physiology KW - Spinal Cord -- metabolism KW - Receptors, AMPA -- physiology KW - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid -- pharmacology KW - Receptors, AMPA -- agonists KW - Calcium Signaling -- drug effects KW - Calcium Signaling -- physiology KW - Cell Membrane Permeability -- drug effects KW - Spinal Cord -- drug effects KW - Motor Neurons -- drug effects KW - Spinal Cord -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/901644317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemistry+international&rft.atitle=AMPA+induced+Ca2%2B+influx+in+motor+neurons+occurs+through+voltage+gated+Ca2%2B+channel+and+Ca2%2B+permeable+AMPA+receptor.&rft.au=Joshi%2C+Dinesh+C%3BSingh%2C+Mahendra%3BKrishnamurthy%2C+Karthik%3BJoshi%2C+Preeti+G%3BJoshi%2C+Nanda+B&rft.aulast=Joshi&rft.aufirst=Dinesh&rft.date=2011-11-01&rft.volume=59&rft.issue=6&rft.spage=913&rft.isbn=&rft.btitle=&rft.title=Neurochemistry+international&rft.issn=1872-9754&rft_id=info:doi/10.1016%2Fj.neuint.2011.06.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2013-01-29 N1 - Date created - 2011-11-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuint.2011.06.023 ER - TY - JOUR T1 - [Molecular diagnosis of HPV infections]. TT - Molekulare Diagnostik der HPV-Infektion. AN - 901308178; 21845360 AB - Carcinogenic human papillomaviruses (HPV) cause the majority of cervical cancers and other anogenital cancers. Large randomized trials have shown that HPV testing can be efficiently used for primary cervical cancer screening. Other applications include the triage of abnormal cytology results and the follow-up of women after treatment. Many assays have been developed to measure DNA, RNA and proteins of HPV and the various tests can have very different applications. It is important to rigorously validate HPV assays before they are implemented in screening or clinical care. JF - Der Pathologe AU - Wentzensen, N AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852-7234, Maryland, USA. wentzenn@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 461 EP - 466 VL - 32 IS - 6 KW - Index Medicus KW - Cervix Uteri -- pathology KW - Genome, Viral -- genetics KW - Cell Transformation, Neoplastic -- pathology KW - Humans KW - Predictive Value of Tests KW - Uterine Cervical Dysplasia -- virology KW - Uterine Cervical Dysplasia -- genetics KW - Precancerous Conditions -- pathology KW - Precancerous Conditions -- virology KW - Uterine Cervical Dysplasia -- pathology KW - Mass Screening KW - Precancerous Conditions -- genetics KW - Vaginal Smears KW - Cervix Uteri -- virology KW - Precancerous Conditions -- diagnosis KW - Uterine Cervical Dysplasia -- diagnosis KW - Cell Transformation, Neoplastic -- genetics KW - Female KW - Papillomavirus Infections -- pathology KW - Papillomavirus Infections -- diagnosis KW - Uterine Cervical Neoplasms -- diagnosis KW - Papillomavirus Infections -- virology KW - Uterine Cervical Neoplasms -- genetics KW - Papillomavirus Infections -- genetics KW - Human papillomavirus 16 -- genetics KW - Molecular Diagnostic Techniques -- methods KW - Uterine Cervical Neoplasms -- pathology KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/901308178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Der+Pathologe&rft.atitle=%5BMolecular+diagnosis+of+HPV+infections%5D.&rft.au=Wentzensen%2C+N&rft.aulast=Wentzensen&rft.aufirst=N&rft.date=2011-11-01&rft.volume=32&rft.issue=6&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Der+Pathologe&rft.issn=1432-1963&rft_id=info:doi/10.1007%2Fs00292-011-1475-6 LA - ger DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-17 N1 - Date created - 2011-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2002 Dec 1;62(23):7075-82 [12460929] J Natl Cancer Inst. 2011 Mar 2;103(5):368-83 [21282563] J Pathol. 1999 Sep;189(1):12-9 [10451482] J Natl Cancer Inst. 2005 Jan 19;97(2):147-50 [15657345] J Clin Virol. 2005 Mar;32 Suppl 1:S43-51 [15753011] Lancet Oncol. 2005 Apr;6(4):204 [15830458] Vaccine. 2006 Aug 31;24 Suppl 3:S3/11-25 [16949997] Dis Markers. 2007;23(4):273-81 [17627062] Dis Markers. 2007;23(4):297-313 [17627064] Dis Markers. 2007;23(4):315-30 [17627065] Lancet. 2007 Sep 8;370(9590):890-907 [17826171] Int J Cancer. 2007 Dec 15;121(12):2787-93 [17722112] Lancet Oncol. 2008 May;9(5):425-34 [18407790] Lancet Oncol. 2008 May;9(5):404-6 [18452848] J Clin Microbiol. 2008 Aug;46(8):2595-604 [18579716] Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2536-45 [18842994] Int J Cancer. 2009 Feb 1;124(3):516-20 [18973271] J Natl Cancer Inst. 2009 Apr 1;101(7):475-87 [19318628] Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1341-9 [19423515] J Med Virol. 2010 Apr;82(4):605-15 [20166179] Cancer Res. 2010 Apr 15;70(8):3159-69 [20354192] Am J Clin Pathol. 2010 Aug;134(2):193-9 [20660320] Am J Surg Pathol. 2010 Aug;34(8):1077-87 [20661011] Int J Cancer. 2011 Feb 15;128(4):927-35 [20473886] Gynecol Oncol. 2011 Mar;120(3):430-8 [21130490] Am J Clin Pathol. 2011 Mar;135(3):468-75 [21350104] Comment In: Pathologe. 2011 Nov;32(6):449-50 [22038131] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00292-011-1475-6 ER - TY - JOUR T1 - Nuclear receptor CAR (NR1I3) is essential for DDC-induced liver injury and oval cell proliferation in mouse liver. AN - 901308056; 21826054 AB - The liver is endowed with the ability to regenerate hepatocytes in response to injury. When this regeneration ability is impaired during liver injury, oval cells, which are considered to be postnatal hepatic progenitors, proliferate and differentiate into hepatocytes. Here we have demonstrated that 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) activates the nuclear receptor constitutive active/androstane receptor (CAR), resulting in proliferation of oval cells in mouse liver. Activation of CAR by DDC was shown by hepatic nuclear CAR accumulation and cytochrome P450 (CYP)2B10 mRNA induction after feeding a 0.1% DDC-containing diet to Car(+/+) mice. After being fed the DDC diet, Car(+/+), but not Car(-/-) mice, developed severe liver injury and an A6 antibody-stained ductular reaction in an area around the portal tract. Oval cell proliferation was confirmed by laser capture microdissection and real-time PCR; mRNAs for the two oval cell markers epithelial cell adhesion molecule and TROP2 were specifically induced in the periportal region of DDC diet-fed Car(+/+), but not Car(-/-) mice. Although rates of both hepatocyte growth and death were initially enhanced only in DDC diet-fed Car(+/+) mice, growth was attenuated when oval cells proliferated, whereas death continued unabated. DDC-induced liver injury, which differs from other CAR activators such as phenobarbital, occurred in the periportal region where cells developed hypertrophy, accumulated porphyrin crystals and inflammation developed, all in association with the proliferation of oval cells. Thus, CAR provides an excellent experimental model for further investigations into its roles in liver regeneration, as well as the development of diseases such as hepatocellular carcinoma. JF - Laboratory investigation; a journal of technical methods and pathology AU - Yamazaki, Yuichi AU - Moore, Rick AU - Negishi, Masahiko AD - Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 1624 EP - 1633 VL - 91 IS - 11 KW - 3,5-diethoxycarbonyl-1,4-dihydrocollidine KW - 0 KW - Antigens, Neoplasm KW - Cell Adhesion Molecules KW - Pyridines KW - Receptors, Cytoplasmic and Nuclear KW - TROP2 protein, mouse KW - constitutive androstane receptor KW - Index Medicus KW - Real-Time Polymerase Chain Reaction KW - Animals KW - Blotting, Western KW - Apoptosis -- physiology KW - Cell Adhesion Molecules -- metabolism KW - Antigens, Neoplasm -- metabolism KW - Mice KW - Laser Capture Microdissection KW - Cell Proliferation KW - Mice, Knockout KW - Liver -- cytology KW - Cell Differentiation -- physiology KW - Liver -- injuries KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - Stem Cells -- physiology KW - Liver Regeneration -- physiology KW - Pyridines -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/901308056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.atitle=Nuclear+receptor+CAR+%28NR1I3%29+is+essential+for+DDC-induced+liver+injury+and+oval+cell+proliferation+in+mouse+liver.&rft.au=Yamazaki%2C+Yuichi%3BMoore%2C+Rick%3BNegishi%2C+Masahiko&rft.aulast=Yamazaki&rft.aufirst=Yuichi&rft.date=2011-11-01&rft.volume=91&rft.issue=11&rft.spage=1624&rft.isbn=&rft.btitle=&rft.title=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.issn=1530-0307&rft_id=info:doi/10.1038%2Flabinvest.2011.115 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-19 N1 - Date created - 2011-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2004 Oct 15;64(20):7197-200 [15492232] Mol Cell Biol. 2004 Sep;24(18):7931-40 [15340055] Biochem J. 1992 Aug 1;285 ( Pt 3):979-83 [1497633] Toxicol Sci. 1998 Jul;44(1):46-51 [9720140] Lab Invest. 1999 Feb;79(2):103-9 [10068199] Mol Cell Biol. 1999 Sep;19(9):6318-22 [10454578] Biochem J. 2005 Jun 1;388(Pt 2):623-30 [15610065] Hepatology. 2006 Feb;43(2 Suppl 1):S45-53 [16447274] J Pharmacol Exp Ther. 2007 Jan;320(1):307-13 [17050775] Hepatology. 2007 Jan;45(1):31-41 [17187411] Gut. 2007 Apr;56(4):565-74 [16950832] Drug Metab Pharmacokinet. 2008;23(1):8-13 [18305370] Mol Pharmacol. 2008 Apr;73(4):1113-21 [18202305] Biochim Biophys Acta. 2008 Apr;1782(4):239-49 [18222182] J Clin Invest. 2008 May;118(5):1911-23 [18382767] Hepatology. 2009 Jan;49(1):318-29 [19111019] Development. 2009 Jun;136(11):1951-60 [19429791] Gastroenterology. 2009 Aug;137(2):466-81 [19470389] Biochem Biophys Res Commun. 2000 Oct 14;277(1):1-6 [11027630] Mol Pharmacol. 2002 Jan;61(1):1-6 [11752199] Mech Dev. 2003 Jan;120(1):117-30 [12490302] Proc Natl Acad Sci U S A. 2003 Sep 30;100 Suppl 1:11881-8 [12902545] Int J Exp Pathol. 1991 Dec;72(6):695-703 [1768614] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/labinvest.2011.115 ER - TY - JOUR T1 - IL-5 receptor α levels in patients with marked eosinophilia or mastocytosis. AN - 901306950; 21762978 AB - IL-5 plays a central role in the development and maintenance of eosinophilia (EO) and eosinophil activation in a wide variety of eosinophilic disorders. Although IL-5, IL-3, and GM-CSF can modulate the expression of IL-5 receptor α (IL-5Rα) on eosinophils in vitro, little is known about soluble and surface IL-5Rα levels in vivo. To assess soluble and surface IL-5Rα levels in patients with EO and/or mastocytosis. Surface IL-5Rα expression was assessed by flow cytometry in blood and/or bone marrow from subjects with EO (n = 39) and systemic mastocytosis (n = 8) and from normal volunteers (n = 28). Soluble IL-5Rα (sIL-5Rα) level was measured in a cohort of 177 untreated subjects and correlated with EO, eosinophil activation, and serum tryptase and cytokine levels. IL-5Rα expression on eosinophils inversely correlated with EO (r = -0.48; P < .0001), whereas serum levels of sIL-5Rα increased with the eosinophil count (r = 0.56; P < .0001) and serum IL-5 (r = 0.40; P < .0001) and IL-13 (r = 0.29; P = .004) levels. Of interest, sIL-5Rα level was significantly elevated in patients with systemic mastocytosis without EO. Although sIL-5Rα levels correlated with serum tryptase levels in these patients, eosinophil activation, assessed by CD69 expression on eosinophils and serum eosinophil-derived neurotoxin levels, was increased compared with that in normal subjects. These data are consistent with an in vivo IL-5Rα regulatory pathway in human eosinophils similar to that described in vitro and involving a balance between soluble and surface receptor levels. This may have implications with respect to the use of novel therapeutic agents targeting IL-5 and its receptor in patients with EO and/or mastocytosis. Published by Mosby, Inc. JF - The Journal of allergy and clinical immunology AU - Wilson, Todd M AU - Maric, Irina AU - Shukla, Juhi AU - Brown, Margaret AU - Santos, Carlo AU - Simakova, Olga AU - Khoury, Paneez AU - Fay, Michael P AU - Kozhich, Alexander AU - Kolbeck, Roland AU - Metcalfe, Dean D AU - Klion, Amy D AD - Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 1086 EP - 92.e1-3 VL - 128 IS - 5 KW - Cytokines KW - 0 KW - IL5RA protein, human KW - Interleukin-5 Receptor alpha Subunit KW - Eosinophil-Derived Neurotoxin KW - EC 3.1.- KW - Tryptases KW - EC 3.4.21.59 KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Eosinophil-Derived Neurotoxin -- immunology KW - Humans KW - Cytokines -- biosynthesis KW - Cytokines -- immunology KW - Tryptases -- blood KW - Aged KW - Cell Separation KW - Eosinophil-Derived Neurotoxin -- biosynthesis KW - Eosinophils -- immunology KW - Cytokines -- analysis KW - Eosinophil-Derived Neurotoxin -- analysis KW - Adult KW - Eosinophils -- metabolism KW - Enzyme-Linked Immunosorbent Assay KW - Middle Aged KW - Flow Cytometry KW - Male KW - Female KW - Mastocytosis, Systemic -- immunology KW - Interleukin-5 Receptor alpha Subunit -- immunology KW - Eosinophilia -- metabolism KW - Interleukin-5 Receptor alpha Subunit -- biosynthesis KW - Mastocytosis, Systemic -- metabolism KW - Eosinophilia -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/901306950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=IL-5+receptor+%CE%B1+levels+in+patients+with+marked+eosinophilia+or+mastocytosis.&rft.au=Wilson%2C+Todd+M%3BMaric%2C+Irina%3BShukla%2C+Juhi%3BBrown%2C+Margaret%3BSantos%2C+Carlo%3BSimakova%2C+Olga%3BKhoury%2C+Paneez%3BFay%2C+Michael+P%3BKozhich%2C+Alexander%3BKolbeck%2C+Roland%3BMetcalfe%2C+Dean+D%3BKlion%2C+Amy+D&rft.aulast=Wilson&rft.aufirst=Todd&rft.date=2011-11-01&rft.volume=128&rft.issue=5&rft.spage=1086&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=1097-6825&rft_id=info:doi/10.1016%2Fj.jaci.2011.05.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-12 N1 - Date created - 2011-10-31 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Blood. 2000 Mar 1;95(5):1600-7 [10688814] Haematologica. 2011 Mar;96(3):459-63 [21134978] Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10509-13 [10973484] Int Arch Allergy Immunol. 2002 Jun;128(2):136-41 [12065914] Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1477-84 [12433730] J Immunol. 2002 Dec 1;169(11):6452-8 [12444154] J Immunol. 2002 Dec 1;169(11):6459-66 [12444155] Allergy. 2003 May;58(5):371-9 [12752323] J Immunol. 2003 Jun 1;170(11):5359-66 [12759409] BMC Biotechnol. 2003 Sep 30;3:17 [14519208] Blood. 2004 Jun 1;103(11):4050-5 [14988154] Allergy. 2004 Oct;59(10):1087-96 [15355468] Int Arch Allergy Immunol. 2004 Sep;135(1):54-61 [15286446] Cell. 1991 Sep 20;66(6):1175-84 [1833065] Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7041-5 [1495999] J Immunol. 1997 Oct 15;159(8):4024-34 [9378992] Blood. 2005 Jan 15;105(2):592-9 [15367434] Eur J Haematol. 2006 Sep;77(3):181-90 [16856933] Blood. 2006 Oct 1;108(7):2366-72 [16741248] N Engl J Med. 2008 Mar 20;358(12):1215-28 [18344568] J Leukoc Biol. 2008 Aug;84(2):499-509 [18511572] Allergy. 2009 Feb;64(2):287-94 [19178408] N Engl J Med. 2009 Mar 5;360(10):973-84 [19264686] N Engl J Med. 2009 Mar 5;360(10):985-93 [19264687] Allergy. 2009 May;64(5):725-32 [19170670] BMC Pulm Med. 2009;9:34 [19602238] J Allergy Clin Immunol. 2010 Jun;125(6):1237-1244.e2 [20513521] J Allergy Clin Immunol. 2010 Jun;125(6):1336-43 [20513524] J Allergy Clin Immunol. 2010 Jun;125(6):1344-1353.e2 [20513525] Blood. 2000 Sep 15;96(6):2163-71 [10979962] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jaci.2011.05.032 ER - TY - JOUR T1 - Transforming growth factor β1 increase of hydroxysteroid dehydrogenase proteins is partly suppressed by red clover isoflavones in human primary prostate cancer-derived stromal cells. AN - 901306109; 21914638 AB - Transforming growth factor β1 (TGF-β1) increases dehydro-epiandrosterone (DHEA) metabolism to androgens and prostate-specific antigen (PSA) in a prostate tissue model where stromal (6S) cells and epithelial (LAPC-4) cells are cocultured. Red clover (RC) isoflavones inhibits transforming growth factor (TGF)-β-induced androgenicity. Mechanisms controlling those activities were explored. Three hydroxysteroid dehydrogenases (HSDs), 3β-HSD, HSD-17β1 and HSD-17β5 involved in metabolizing DHEA to testosterone (TESTO) were investigated. Individual depletion of HSDs in 6S cells significantly reduced TGF-β1/DHEA-induced PSA in LAPC-4 cells in cocultures. Monomer amounts of 3β-HSD were similar without or with TGF-β1 in both cell types but aggregates of 3β-HSD in 6S cells were much higher than those in LAPC-4 cells and were upregulated by TGFβ in 6S cells. Basal and TGF-β1-treated levels of HSD-17β1 and HSD-17β5 in LAPC-4 cells were significantly lower than in 6S cells, whereas levels of HSD-17β1 but not HSD-17β5 were TGFβ inducible. 6S cell HSD genes expression induced by TGFβ or androgen signaling was insignificant to contribute TGF-β1/DHEA-upregulated protein levels of HSDs. RC decreased TGF-β1- upregulation of aggregates of 3β-HSD but not HSD-17β1. Depletion of TGFβ receptors (TGFβ Rs) reduced TGF-β1/DHEA-upregulated HSDs and TESTO. Immunoprecipitation studies demonstrated that TGF-β1 disrupted associations of TGFβ Rs/HSDs aggregates, whereas RC suppressed the dissociations of aggregates of 3β-HSD but not HSD-17β1 from the receptors. Given that TGFβ Rs are recycled with or without ligand, TGF-β1-induced disassociation of the HSDs from TGFβ Rs may increase stability and activity of the HSDs. These data suggest a pathway connecting overproduction of TGFβ with increased PSA in prostate cancer. JF - Carcinogenesis AU - Liu, Xunxian AU - Piao, Yun-Shang AU - Arnold, Julia T AD - Endocrine Section, Intramural Research Program, National Center for Complementary and Alternative Medicine, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20892, USA. xunxianl@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 1648 EP - 1654 VL - 32 IS - 11 KW - Isoflavones KW - 0 KW - Receptors, Transforming Growth Factor beta KW - Transforming Growth Factor beta1 KW - Testosterone KW - 3XMK78S47O KW - 3-Hydroxysteroid Dehydrogenases KW - EC 1.1.- KW - Hydroxysteroid Dehydrogenases KW - AKR1C3 protein, human KW - EC 1.1.1.- KW - Hydroxyprostaglandin Dehydrogenases KW - Estradiol Dehydrogenases KW - EC 1.1.1.62 KW - HSD17B1 protein, human KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Index Medicus KW - Real-Time Polymerase Chain Reaction KW - Prostatic Neoplasms -- metabolism KW - Estradiol Dehydrogenases -- antagonists & inhibitors KW - Receptors, Transforming Growth Factor beta -- genetics KW - Prostate -- drug effects KW - Immunoblotting KW - 3-Hydroxysteroid Dehydrogenases -- metabolism KW - 3-Hydroxysteroid Dehydrogenases -- genetics KW - Humans KW - Receptors, Transforming Growth Factor beta -- metabolism KW - Prostate -- metabolism KW - Immunoprecipitation KW - Hydroxyprostaglandin Dehydrogenases -- antagonists & inhibitors KW - Prostatic Neoplasms -- drug therapy KW - Hydroxyprostaglandin Dehydrogenases -- metabolism KW - Prostatic Neoplasms -- pathology KW - Estradiol Dehydrogenases -- genetics KW - Estradiol Dehydrogenases -- metabolism KW - Hydroxyprostaglandin Dehydrogenases -- genetics KW - Cells, Cultured KW - Prostate-Specific Antigen -- metabolism KW - 3-Hydroxysteroid Dehydrogenases -- antagonists & inhibitors KW - Male KW - Testosterone -- metabolism KW - Stromal Cells -- drug effects KW - Isoflavones -- pharmacology KW - Hydroxysteroid Dehydrogenases -- metabolism KW - Hydroxysteroid Dehydrogenases -- genetics KW - Transforming Growth Factor beta1 -- pharmacology KW - Stromal Cells -- metabolism KW - Hydroxysteroid Dehydrogenases -- antagonists & inhibitors KW - Trifolium -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/901306109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Transforming+growth+factor+%CE%B21+increase+of+hydroxysteroid+dehydrogenase+proteins+is+partly+suppressed+by+red+clover+isoflavones+in+human+primary+prostate+cancer-derived+stromal+cells.&rft.au=Liu%2C+Xunxian%3BPiao%2C+Yun-Shang%3BArnold%2C+Julia+T&rft.aulast=Liu&rft.aufirst=Xunxian&rft.date=2011-11-01&rft.volume=32&rft.issue=11&rft.spage=1648&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgr206 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-22 N1 - Date created - 2011-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Prostate. 2000 Oct 1;45(2):140-8 [11027413] Prostate. 2011 May 15;71(7):766-77 [21031436] Nat Rev Mol Cell Biol. 2000 Dec;1(3):169-78 [11252892] J Urol. 2001 Dec;166(6):2472-83 [11696814] Clin Cancer Res. 2002 Sep;8(9):2912-23 [12231536] Mol Biol Cell. 2004 Sep;15(9):4166-78 [15229286] N Engl J Med. 1986 Dec 25;315(26):1650-9 [3537791] Ann N Y Acad Sci. 1994 May 31;719:553-63 [8010623] Steroids. 1996 Jan;61(1):41-6 [8789735] Exp Cell Res. 1997 May 1;232(2):208-15 [9168795] Prostate. 1999 Jun 1;39(4):285-90 [10344218] Mech Ageing Dev. 2005 Jan;126(1):59-69 [15610763] Curr Biol. 2005 Nov 22;15(22):1989-97 [16303557] Am J Physiol Endocrinol Metab. 2006 May;290(5):E952-60 [16368782] Nat Rev Cancer. 2006 Jul;6(7):506-20 [16794634] Endocrinology. 2006 Dec;147(12):5806-16 [16959841] Clin Dermatol. 2007 Jan-Feb;25(1):56-62 [17276202] Carcinogenesis. 2008 Apr;29(4):816-23 [18283040] Best Pract Res Clin Endocrinol Metab. 2008 Apr;22(2):207-21 [18471780] J Steroid Biochem Mol Biol. 2008 Sep;111(3-5):240-6 [18621129] ChemMedChem. 2008 Sep;3(9):1371-6 [18576452] Cancer Prev Res (Phila). 2009 Feb;2(2):134-42 [19141600] Mol Cell Endocrinol. 2009 Mar 25;301(1-2):83-8 [19013497] Clin Cancer Res. 2009 Aug 1;15(15):4815-22 [19638459] Endocr Relat Cancer. 2009 Dec;16(4):1139-55 [19608712] Trends Immunol. 2010 Jun;31(6):220-7 [20538542] J Mol Endocrinol. 2001 Feb;26(1):11-9 [11174850] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgr206 ER - TY - JOUR T1 - Immunological detection of N-formylkynurenine in porphyrin-mediated photooxided lens α-crystallin. AN - 900637813; 21770952 AB - Crystallin proteins are responsible for maintaining lens transparency and allowing the lens to focus light undistorted onto the retina. The α-crystallins are the major lens crystallins, and function as both structural proteins and chaperones to protect all lens proteins from damage leading to lens deterioration. Because lens crystallin proteins do not turn over, the damage they accumulate can lead to cataracts, the world's leading cause of blindness. Photosensitizing porphyrins can accumulate in the eye through either endogenous metabolism or through therapeutic or diagnostic procedures. Porphyrin buildup exacerbates lens aging through increased levels of singlet oxygen, resulting in protein polymerization and amino acid residue alteration. Tryptophans oxidize to kynurenine and N-formylkynurenine (NFK) causing irreversible changes in the refractive index of the normally transparent lens, leading to development of cataracts. Additionally, NFK is itself a photosensitizer, and its presence exacerbates lens deterioration. This work uses anti-NFK antiserum to study porphyrin-facilitated photooxidation of α-crystallin tryptophan residues. In vitro experiments show that four biologically interesting porphyrins mediate α-crystallin polymerization and accumulation of both protein radicals and NFK. Confocal microscopy of cultured human lens epithelial cells indicates that while all four porphyrins photosensitize cellular proteins, not all oxidize the tryptophans of cellular α-crystallin to NFK. © 2011 The Authors. Photochemistry and Photobiology © 2011 The American Society of Photobiology. JF - Photochemistry and photobiology AU - Ehrenshaft, Marilyn AU - Zhao, Baozhong AU - Andley, Usha P AU - Mason, Ronald P AU - Roberts, Joan E AD - Laboratory of Pharmacology and Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. ehrensh1@niehs.nih.gov PY - 2011 SP - 1321 EP - 1329 VL - 87 IS - 6 KW - Porphyrins KW - 0 KW - alpha-Crystallins KW - N'-formylkynurenine KW - 1022-31-7 KW - Kynurenine KW - 343-65-7 KW - Index Medicus KW - Oxidation-Reduction KW - Microscopy, Confocal KW - Refractometry KW - Humans KW - Cell Line KW - Photochemistry KW - Kynurenine -- analysis KW - alpha-Crystallins -- chemistry KW - Porphyrins -- chemistry KW - Kynurenine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900637813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Immunological+detection+of+N-formylkynurenine+in+porphyrin-mediated+photooxided+lens+%CE%B1-crystallin.&rft.au=Ehrenshaft%2C+Marilyn%3BZhao%2C+Baozhong%3BAndley%2C+Usha+P%3BMason%2C+Ronald+P%3BRoberts%2C+Joan+E&rft.aulast=Ehrenshaft&rft.aufirst=Marilyn&rft.date=2011-11-01&rft.volume=87&rft.issue=6&rft.spage=1321&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=1751-1097&rft_id=info:doi/10.1111%2Fj.1751-1097.2011.00979.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-25 N1 - Date created - 2011-10-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Photochem Photobiol. 2000 Aug;72(2):200-3 [10946573] Curr Opin Ophthalmol. 2011 Jan;22(1):4-9 [21107260] Exp Eye Res. 2003 Feb;76(2):145-53 [12565801] Free Radic Biol Med. 2003 Mar 15;34(6):637-47 [12633741] Biochem Biophys Res Commun. 2003 Jun 6;305(3):761-70 [12763058] Photochem Photobiol. 2003 May;77(5):567-71 [12812302] J Biol Chem. 2003 Jun 27;278(26):24078-89 [12686560] Photochem Photobiol Sci. 2004 Jan;3(1):17-25 [14743273] Curr Eye Res. 1985 Mar;4(3):181-5 [4017621] Lasers Surg Med. 1987;7(1):6-11 [3573938] Photochem Photobiol. 1987 Nov;46(5):683-8 [3441495] Photochem Photobiol. 1990 Apr;51(4):465-8 [2343063] Photochem Photobiol. 1990 Oct;52(4):761-8 [2089424] Photochem Photobiol. 1990 Oct;52(4):849-54 [2089434] Photochem Photobiol. 1991 Jan;53(1):33-8 [1851303] Biochemistry. 1991 Sep 3;30(35):8653-60 [1888728] Photochem Photobiol. 1991 Nov;54(5):855-7 [1798759] J Photochem Photobiol B. 1992 Feb 28;12(3):275-84 [1635012] Curr Eye Res. 1992 Nov;11(11):1121-5 [1336447] Invest Ophthalmol Vis Sci. 1994 Jun;35(7):3094-102 [8206728] Cancer Res. 1995 Jun 15;55(12):2620-6 [7780978] J Photochem Photobiol B. 1995 May;28(2):155-61 [7636637] Photochem Photobiol. 1995 Aug;62(2):339-41 [7480141] Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15185-9 [8986785] Protein Sci. 1998 Nov;7(11):2391-7 [9828005] Free Radic Biol Med. 2004 Dec 15;37(12):2018-26 [15544920] Biochim Biophys Acta. 2005 Jan 17;1703(2):93-109 [15680218] Prog Retin Eye Res. 2007 Jan;26(1):78-98 [17166758] Semin Liver Dis. 2007 Feb;27(1):99-108 [17295179] Int J Biochem Cell Biol. 2008;40(3):317-23 [18093866] Mol Cell Biochem. 2008 Mar;310(1-2):235-9 [18158587] Eur J Pharm Biopharm. 2008 Aug;69(3):1083-93 [18396019] Free Radic Biol Med. 2009 May 1;46(9):1260-6 [19353782] Free Radic Biol Med. 2009 Jul 1;47(1):92-102 [19375501] Photochem Photobiol. 2009 Nov-Dec;85(6):1306-13 [19709381] J Am Soc Mass Spectrom. 2010 Jul;21(7):1114-7 [20219394] Photochem Photobiol. 2010 Jul-Aug;86(4):752-6 [20408979] Free Radic Biol Med. 2010 Sep 15;49(6):1046-53 [20600836] Am J Physiol Endocrinol Metab. 2011 Jun;300(6):E1047-58 [21386058] Photochem Photobiol. 2001 Nov;74(5):740-4 [11723804] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1751-1097.2011.00979.x ER - TY - JOUR T1 - Genomic-derived markers for early detection of calcineurin inhibitor immunosuppressant-mediated nephrotoxicity. AN - 900627565; 21865292 AB - Calcineurin inhibitor (CI) therapy has been associated with chronic nephrotoxicity, which limits its long-term utility for suppression of allograft rejection. In order to understand the mechanisms of the toxicity, we analyzed gene expression changes that underlie the development of CI immunosuppressant-mediated nephrotoxicity in male Sprague-Dawley rats dosed daily with cyclosporine (CsA; 2.5 or 25 mg/kg/day), FK506 (0.6 or 6 mg/kg/day), or rapamycin (1 or 10 mg/kg/day) for 1, 7, 14, or 28 days. A significant increase in blood urea nitrogen was observed in animals treated with CsA (high) or FK506 (high) for 14 and 28 days. Histopathological examination revealed tubular basophilia and mineralization in animals given CsA (high) or FK506 (low and high). We identified a group of genes whose expression in rat kidney is correlated with CI-induced kidney injury. Among these genes are two genes, Slc12a3 and kidney-specific Wnk1 (KS-Wnk1), that are known to be involved in sodium transport in the distal nephrons and could potentially be involved in the mechanism of CI-induced nephrotoxicity. The downregulation of NCC (the Na-Cl cotransporter coded by Slc12a3) in rat kidney following CI treatment was confirmed by immunohistochemical staining, and the downregulation of KS-Wnk1 was confirmed by quantitative real-time-polymerase chain reaction (qRT-PCR). We hypothesize that decreased expression of Slc12a3 and KS-Wnk1 could alter the sodium chloride reabsorption in the distal tubules and contribute to the prolonged activation of the renin-angiotensin system, a demonstrated contributor to the development of CI-induced nephrotoxicity in both animal models and clinical settings. Therefore, if validated as biomarkers in humans, SLC12A3 and KS-WNK1 could potentially be useful in the early detection and reduction of CI-related nephrotoxicity in immunosuppressed transplant patients when monitoring the health of kidney xenographs in clinical practice. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Cui, Yuxia AU - Huang, Qihong AU - Auman, James Todd AU - Knight, Brian AU - Jin, Xidong AU - Blanchard, Kerry T AU - Chou, Jeff AU - Jayadev, Supriya AU - Paules, Richard S AD - Environmental Stress and Cancer Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 23 EP - 34 VL - 124 IS - 1 KW - Calcineurin Inhibitors KW - 0 KW - Genetic Markers KW - Immunosuppressive Agents KW - Minor Histocompatibility Antigens KW - Receptors, Drug KW - Slc12a3 protein, rat KW - Solute Carrier Family 12, Member 3 KW - Symporters KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - Wnk1 protein, rat KW - Index Medicus KW - Animals KW - Kidney -- metabolism KW - Kidney -- pathology KW - Kidney Transplantation KW - Kidney -- drug effects KW - Graft Rejection -- prevention & control KW - Rats KW - Rats, Sprague-Dawley KW - Down-Regulation KW - Chronic Disease KW - Renin-Angiotensin System -- drug effects KW - Early Diagnosis KW - Immunohistochemistry KW - Male KW - Receptors, Drug -- genetics KW - Kidney Diseases -- physiopathology KW - Kidney Diseases -- pathology KW - Kidney Diseases -- genetics KW - Symporters -- genetics KW - Immunosuppressive Agents -- toxicity KW - Protein-Serine-Threonine Kinases -- genetics KW - Immunosuppressive Agents -- therapeutic use KW - Kidney Diseases -- chemically induced KW - Immunosuppressive Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900627565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Genomic-derived+markers+for+early+detection+of+calcineurin+inhibitor+immunosuppressant-mediated+nephrotoxicity.&rft.au=Cui%2C+Yuxia%3BHuang%2C+Qihong%3BAuman%2C+James+Todd%3BKnight%2C+Brian%3BJin%2C+Xidong%3BBlanchard%2C+Kerry+T%3BChou%2C+Jeff%3BJayadev%2C+Supriya%3BPaules%2C+Richard+S&rft.aulast=Cui&rft.aufirst=Yuxia&rft.date=2011-11-01&rft.volume=124&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfr217 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-12 N1 - Date created - 2011-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Hepatol. 2011 May;54(5):1041-54 [21145927] Transplantation. 2011 Jan 15;91(1):115-20 [21452415] J Am Soc Nephrol. 2000 Dec;11(12):2265-71 [11095649] Nephrol Dial Transplant. 2001 Feb;16(2):378-82 [11158416] Science. 2001 Aug 10;293(5532):1107-12 [11498583] Transplantation. 2001 Sep 15;72(5):777-86 [11571437] Transplantation. 2001 Dec 15;72(11):1826-9 [11740395] Curr Opin Crit Care. 2001 Dec;7(6):384-9 [11805539] Curr Drug Metab. 2002 Feb;3(1):61-71 [11876576] Nephron. 2002 Dec;92(4):914-21 [12399639] Kidney Int. 2002 Dec;62(6):2055-61 [12427129] Int J Mol Med. 2003 Jan;11(1):75-8 [12469222] J Am Soc Nephrol. 2004 Mar;15(3):549-57 [14978156] Nephron Physiol. 2004;96(3):p65-78 [15056980] Transplantation. 2004 Aug 27;78(4):557-65 [15446315] Proc Natl Acad Sci U S A. 1981 Dec;78(12):7579-83 [6278480] Science. 1987 Sep 25;237(4822):1618-20 [3306925] Am J Physiol. 1987 Dec;253(6 Pt 2):H1596-600 [3322045] Transplantation. 1988 Aug;46(2):285-92 [3406978] Am J Physiol. 1991 Apr;260(4 Pt 2):F486-93 [2012204] Kidney Int. 1993 Mar;43(3):615-22 [8455360] J Am Soc Nephrol. 1993 Aug;4(2):214-21 [8400085] Clin Exp Pharmacol Physiol. 1995 Sep;22(9):646-54 [8542679] Lab Invest. 1995 Dec;73(6):794-803 [8558840] Nat Genet. 1996 Jan;12(1):24-30 [8528245] J Am Soc Nephrol. 1995 Oct;6(4):1186-96 [8589285] J Hypertens. 1996 Jul;14(7):815-22 [8818919] Biochem Pharmacol. 1997 Mar 7;53(5):723-31 [9113092] Kidney Int. 1997 Jul;52(1):248-60 [9211371] Am J Kidney Dis. 1997 Jul;30(1):71-81 [9214404] Transplantation. 1997 Aug 15;64(3):436-43 [9275110] J Biol Chem. 1998 Oct 30;273(44):29150-5 [9786924] Transplantation. 1998 Dec 27;66(12):1736-40 [9884269] Nephron Exp Nephrol. 2005;99(1):e9-16 [15637465] Toxicol Pathol. 2005;33(3):343-55 [15805072] J Bioinform Comput Biol. 2005 Apr;3(2):225-41 [15852502] J Clin Invest. 2005 May;115(5):1379-87 [15841204] Adv Chronic Kidney Dis. 2006 Jan;13(1):47-55 [16412970] Am J Physiol Renal Physiol. 2006 Mar;290(3):F619-24 [16204408] Am J Transplant. 2006;6(5 Pt 2):1111-31 [16613591] Curr Hypertens Rep. 2006 May;8(2):158-65 [16672150] Eur J Clin Invest. 2006 Nov;36(11):753-63 [17032342] J Am Soc Nephrol. 2007 Feb;18(2):421-9 [17202415] Pharmacol Rev. 2007 Sep;59(3):251-87 [17878513] BMC Bioinformatics. 2007;8:427 [17980031] Kidney Int. 2008 Mar;73(5):608-14 [18160964] Kidney Int. 2008 Mar;73(5):522-3 [18274540] Hypertension. 2008 Mar;51(3):588-96 [18212265] J Cell Sci. 2008 Mar 1;121(Pt 5):675-84 [18270262] Toxicology. 2008 Apr 18;246(2-3):91-100 [18289764] Urology. 2008 Apr;71(4):630-3 [18387391] Chin Med J (Engl). 2008 Jun 5;121(11):983-8 [18706245] Clin J Am Soc Nephrol. 2009 Feb;4(2):481-508 [19218475] Transplantation. 2010 Mar 15;89(5):537-47 [20147884] Transplant Proc. 2010 Mar;42(2):473-4 [20304168] Pharmacogenomics. 2010 Oct;11(10):1491-501 [21047207] Transplant Proc. 2010 Nov;42(9 Suppl):S21-4 [21095445] J Biol Chem. 2000 Jun 2;275(22):16795-801 [10828064] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfr217 ER - TY - JOUR T1 - Potentiation of platelet-derived growth factor receptor-β signaling mediated by integrin-associated MFG-E8. AN - 900627512; 21868707 AB - Pericytes/pericyte precursors produce milk fat globule-associated protein with epidermal growth factor and factor VIII-like domains (MFG-E8) in vivo, and this α(v) integrin ligand enhances angiogenesis in tumors and in oxygen-induced retinopathy in mice. Inhibition of MFG-E8 production or function attenuates platelet-derived growth factor-BB (PDGF-BB)-induced migration of pericyte/pericyte precursor-like 10T1/2 cells in vitro. Herein, we describe mechanisms by which MFG-E8 modulates PDGF-BB:PDGF receptor β (PDGFRβ) signaling in 10T1/2 cells. Small interfering RNA depletion of MFG-E8 from 10T1/2 cells or antibody inhibition of MFG-E8 action enhanced PDGF-BB-dependent degradation of PDGFRβ and attenuated signaling. Coimmunoprecipitation revealed transient association of MFG-E8 with PDGFRβ in PDGF-BB-treated 10T1/2 cells and reduced PDGFRβ-focal adhesion kinase association in MFG-E8-depleted cells. Confocal microscopy demonstrated that MFG-E8 binding to 10T1/2 cells was RGD motif and α(v) dependent but PDGF-BB treatment independent, whereas colocalization of MFG-E8 with PDGFRβ was enhanced by PDGF-BB. Ubiquitination of PDGFRβ was also increased in MFG-E8 small interfering RNA-transfected cells. Integrin α(v)-bound MFG-E8 associates with PDGFRβ and focal adhesion kinase after PDGF-BB treatment, results in cell surface retention of PDGFRβ, delays receptor degradation, potentiates downstream signaling, and enhances migration of 10T1/2 cells. MFG-E8 may promote angiogenesis, in part, via cell autonomous actions on pericytes or pericyte precursors that result in enhanced PDGF-BB:PDGFRβ signaling mediated via integrin-growth factor receptor cross-talk. JF - Arteriosclerosis, thrombosis, and vascular biology AU - Motegi, Sei-ichiro AU - Garfield, Susan AU - Feng, Xu AU - Sárdy, Miklós AU - Udey, Mark C AD - Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20802-1908, USA. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 2653 EP - 2664 VL - 31 IS - 11 KW - Antigens, Surface KW - 0 KW - Integrin alphaV KW - Mfge8 protein, mouse KW - Milk Proteins KW - Platelet-Derived Growth Factor KW - Proto-Oncogene Proteins c-sis KW - RNA, Small Interfering KW - becaplermin KW - 1B56C968OA KW - Receptor, Platelet-Derived Growth Factor beta KW - EC 2.7.10.1 KW - Focal Adhesion Kinase 1 KW - EC 2.7.10.2 KW - Ptk2 protein, mouse KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Models, Animal KW - Animals KW - Platelet-Derived Growth Factor -- metabolism KW - Platelet-Derived Growth Factor -- pharmacology KW - Mice KW - Extracellular Signal-Regulated MAP Kinases -- metabolism KW - Cells, Cultured KW - Cell Movement -- physiology KW - Phosphorylation -- physiology KW - Cell Movement -- drug effects KW - Mice, Inbred C3H KW - RNA, Small Interfering -- pharmacology KW - Focal Adhesion Kinase 1 -- metabolism KW - Cell Line KW - Embryonic Stem Cells -- cytology KW - Integrin alphaV -- metabolism KW - Pericytes -- metabolism KW - Receptor, Platelet-Derived Growth Factor beta -- metabolism KW - Pericytes -- cytology KW - Milk Proteins -- metabolism KW - Pericytes -- drug effects KW - Signal Transduction -- physiology KW - Embryonic Stem Cells -- drug effects KW - Embryonic Stem Cells -- metabolism KW - Milk Proteins -- antagonists & inhibitors KW - Antigens, Surface -- drug effects KW - Antigens, Surface -- metabolism KW - Milk Proteins -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900627512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arteriosclerosis%2C+thrombosis%2C+and+vascular+biology&rft.atitle=Potentiation+of+platelet-derived+growth+factor+receptor-%CE%B2+signaling+mediated+by+integrin-associated+MFG-E8.&rft.au=Motegi%2C+Sei-ichiro%3BGarfield%2C+Susan%3BFeng%2C+Xu%3BS%C3%A1rdy%2C+Mikl%C3%B3s%3BUdey%2C+Mark+C&rft.aulast=Motegi&rft.aufirst=Sei-ichiro&rft.date=2011-11-01&rft.volume=31&rft.issue=11&rft.spage=2653&rft.isbn=&rft.btitle=&rft.title=Arteriosclerosis%2C+thrombosis%2C+and+vascular+biology&rft.issn=1524-4636&rft_id=info:doi/10.1161%2FATVBAHA.111.233619 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-23 N1 - Date created - 2011-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1161/ATVBAHA.111.233619 ER - TY - JOUR T1 - Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of SMADS and TAK1 in early mouse embryo. AN - 900625772; 21953618 AB - Hepatocyte growth factor-regulated tyrosine kinase substrate that is encoded by Hgs promotes degradation of ubiquitinated signaling molecule in the early endosome. We previously reported that a targeted mutation in Hgs results in embryonic lethality soon after gastrulation in the mouse. Here, we report that downstream target genes for BMP signaling were highly down-regulated in the Hgs mutant embryos. We also showed that Hgs is required for phosphorylation of SMAD1/5/8 and TAK1/p38 to transduce BMP signaling. Furthermore, we found that HGS functions to localize TAK1 in early endosome for its activation. These results suggest that HGS is critical to localize TAK1 to early endosome for transducing BMP signaling for proper development. Our data revealed a new mechanism to modify BMP signaling by Hgs during early mouse development. Copyright © 2011 Wiley-Liss, Inc. JF - Developmental dynamics : an official publication of the American Association of Anatomists AU - Miura, Shigeto AU - Mishina, Yuji AD - Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 2474 EP - 2481 VL - 240 IS - 11 KW - Bmp4 protein, mouse KW - 0 KW - Bone Morphogenetic Protein 4 KW - Bone Morphogenetic Proteins KW - Endosomal Sorting Complexes Required for Transport KW - Phosphoproteins KW - Smad Proteins KW - hepatocyte growth factor-regulated tyrosine kinase substrate KW - MAP Kinase Kinase Kinases KW - EC 2.7.11.25 KW - MAP kinase kinase kinase 7 KW - Index Medicus KW - Bone Morphogenetic Protein 4 -- genetics KW - Signal Transduction -- physiology KW - Animals KW - Phosphorylation KW - Signal Transduction -- genetics KW - Bone Morphogenetic Protein 4 -- metabolism KW - Mice KW - Tissue Distribution KW - Models, Biological KW - Protein Transport KW - Mice, Knockout KW - Embryonic Development -- genetics KW - MAP Kinase Kinase Kinases -- metabolism KW - Smad Proteins -- metabolism KW - Phosphoproteins -- genetics KW - Blastocyst -- metabolism KW - Endosomal Sorting Complexes Required for Transport -- physiology KW - Phosphoproteins -- physiology KW - Bone Morphogenetic Proteins -- physiology KW - Bone Morphogenetic Proteins -- metabolism KW - Endosomal Sorting Complexes Required for Transport -- metabolism KW - Endosomal Sorting Complexes Required for Transport -- genetics KW - Phosphoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900625772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+dynamics+%3A+an+official+publication+of+the+American+Association+of+Anatomists&rft.atitle=Hepatocyte+growth+factor-regulated+tyrosine+kinase+substrate+%28Hgs%29+is+involved+in+BMP+signaling+through+phosphorylation+of+SMADS+and+TAK1+in+early+mouse+embryo.&rft.au=Miura%2C+Shigeto%3BMishina%2C+Yuji&rft.aulast=Wentzensen&rft.aufirst=Nicolas&rft.date=2011-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Scientific+Meeting+of+the+American+Society+of+Cytopathology+%28ASC+2011%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-16 N1 - Date created - 2011-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Development. 2007 Sep;134(18):3359-69 [17699604] Cancer Res. 2007 Jun 1;67(11):5162-71 [17545595] J Cell Biol. 2009 Jan 26;184(2):323-34 [19153222] Endocrinology. 2009 Nov;150(11):4989-98 [19819979] Differentiation. 2010 Feb;79(2):84-92 [19889495] Dev Biol. 2010 May 1;341(1):246-54 [20211162] Nature. 2000 Mar 2;404(6773):95-9 [10716450] Mol Cell Biol. 2000 Dec;20(24):9346-55 [11094085] Development. 2001 Jan;128(2):155-66 [11124112] J Biol Chem. 2001 Aug 10;276(32):29943-52 [11397816] J Cell Sci. 2001 Jun;114(Pt 12):2255-63 [11493665] Cell. 2002 Jan 25;108(2):261-9 [11832215] Genes Cells. 2002 Mar;7(3):321-31 [11918675] Sci STKE. 2002 Sep 24;2002(151):pe40 [12297674] Front Biosci. 2003 May 1;8:d855-69 [12700086] Cell. 2003 Oct 31;115(3):281-92 [14636556] Dev Biol. 2004 Jun 1;270(1):47-63 [15136140] Development. 2004 Jun;131(11):2749-62 [15148304] Development. 2004 Aug;131(15):3501-12 [15215210] Cell. 1991 Mar 8;64(5):915-25 [1900457] Development. 1992 Dec;116(4):1123-36 [1363541] Development. 1994 Jul;120(7):1919-28 [7924997] Dev Dyn. 1995 Jun;203(2):163-73 [7655079] Genes Dev. 1995 Sep 1;9(17):2105-16 [7657163] Mech Dev. 1996 Apr;55(2):185-99 [8861098] Mol Biol Cell. 1996 Mar;7(3):355-67 [8868465] Dev Dyn. 1996 Nov;207(3):235-52 [8922523] J Biol Chem. 1997 Aug 15;272(33):20538-44 [9252367] Mech Dev. 1997 Nov;68(1-2):45-57 [9431803] EMBO J. 1998 Feb 16;17(4):1019-28 [9463380] Genes Dev. 1998 Mar 15;12(6):844-57 [9512518] Cell. 1998 Oct 30;95(3):379-91 [9814708] EMBO J. 1999 Jan 4;18(1):179-87 [9878061] Nature. 1999 Mar 18;398(6724):252-6 [10094049] Genes Dev. 1999 Jun 1;13(11):1475-85 [10364163] Nat Genet. 1999 Aug;22(4):361-5 [10431240] Dev Biol. 2004 Dec 1;276(1):185-93 [15531373] Cytokine Growth Factor Rev. 2005 Jun;16(3):265-78 [15871922] Development. 2006 Apr;133(8):1529-41 [16556914] J Mol Cell Cardiol. 2006 Jul;41(1):26-33 [16716349] Dev Biol. 2006 Aug 15;296(2):458-75 [16839541] Dev Cell. 2006 Sep;11(3):313-23 [16950123] Development. 2006 Oct;133(19):3767-75 [16943278] J Biol Chem. 2007 Mar 2;282(9):6075-89 [17197697] Oncogene. 2007 May 14;26(22):3214-26 [17496917] Nat Chem Biol. 2008 Jan;4(1):33-41 [18026094] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/dvdy.22750 ER - TY - JOUR T1 - Quantitative analysis of AgNOR proteins in buccal epithelial cells of Indian street boys addicted to gasp 'golden glue' AN - 899165882; 15795526 AB - The effect of glue snuffle on the expression of argyrophilic nucleolar organizer regions (AgNORs), an indicator of ribosome biosynthesis, in epithelial cells of oral mucosa has been investigated. AgNOR was evaluated by cytochemical staining in 148 Indian street boys (median age 12 year) who had different bad addictions like tobacco smoking, chewing and most importantly inhaling glue and 20 age- and body mass index-matched school boys who had no such type of bad habit. Compared with school boys, glue addicted street boys showed remarkably increased number of AgNOR dots per nucleus (9.38 +/- 1.84 vs. 3.12 +/- 0.87, p 0.001), AgNOR size (1.34 +/- 0.52 vs. 0.43 +/- 0.02 mu m super(2, p 0.001) and percentage of AgNOR occupied nuclear area (9.38 +/- 2.12 vs. 0.99 +/- 0.03%, p 0.001). Increase in number and size of the dots is also higher in tobacco smokers and chewers when compared with school boys but a remarkable difference was recorded in glue addicted boys. The changes in AgNOR expression were positively associated with years of addiction after controlling potential confounders. Thus, glue snuffle appeared to be a risk factor for abnormal cell growth via up-regulation of ribosome biogenesis.) JF - Experimental and Toxicologic Pathology AU - Mondal, Nandan Kumar AU - Ghosh, Sreenita AU - Ray, Manas Ranjan AD - Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700 026, India, nandan_gm@yahoo.com Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 677 EP - 681 PB - Elsevier B.V., P.O. Box 100537 Jena D-07705 Germany VL - 63 IS - 7-8 SN - 0940-2993, 0940-2993 KW - Toxicology Abstracts KW - Tobacco smoking KW - Epithelial cells KW - Age KW - Nucleoli KW - Chewing KW - Body mass KW - Mucosa KW - Ribosomes KW - Risk factors KW - Addiction KW - Nuclei KW - Drug addiction KW - Adhesives KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899165882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+Toxicologic+Pathology&rft.atitle=Quantitative+analysis+of+AgNOR+proteins+in+buccal+epithelial+cells+of+Indian+street+boys+addicted+to+gasp+%27golden+glue%27&rft.au=Mondal%2C+Nandan+Kumar%3BGhosh%2C+Sreenita%3BRay%2C+Manas+Ranjan&rft.aulast=Mondal&rft.aufirst=Nandan&rft.date=2011-11-01&rft.volume=63&rft.issue=7-8&rft.spage=677&rft.isbn=&rft.btitle=&rft.title=Experimental+and+Toxicologic+Pathology&rft.issn=09402993&rft_id=info:doi/10.1016%2Fj.etp.2010.05.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Tobacco smoking; Nucleoli; Age; Chewing; Body mass; Mucosa; Ribosomes; Risk factors; Addiction; Adhesives; Drug addiction; Nuclei DO - http://dx.doi.org/10.1016/j.etp.2010.05.010 ER - TY - JOUR T1 - The Escherichia coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis. AN - 898509015; 21908668 AB - Manganese is a critical micronutrient for cells, serving as an enzyme cofactor and protecting against oxidative stress. Yet, manganese is toxic in excess and little is known about its distribution in cells. Bacteria control intracellular manganese levels by the transcription regulator MntR. When this work began, the only Escherichia coli K-12 gene known to respond to manganese via MntR repression was mntH, which encodes a manganese importer. We show that mntS (formerly the small RNA gene rybA) is repressed by manganese through MntR and encodes an unannotated 42-amino-acid protein. Overproduction of MntS causes manganese sensitivity, while a lack of MntS perturbs proper manganese-dependent repression of mntH. We also provide evidence that mntP (formerly yebN), which encodes a putative efflux pump, is positively regulated by MntR. Deletion of mntP leads to profound manganese sensitivity and to elevated intracellular manganese levels. This work thus defines two new proteins involved in manganese homeostasis and suggests mechanisms for their action. JF - Journal of bacteriology AU - Waters, Lauren S AU - Sandoval, Melissa AU - Storz, Gisela AD - Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 5887 EP - 5897 VL - 193 IS - 21 KW - Escherichia coli Proteins KW - 0 KW - Membrane Transport Proteins KW - MntP protein, E coli KW - MntR protein, E coli KW - MntS protein, E coli KW - Repressor Proteins KW - Manganese KW - 42Z2K6ZL8P KW - Index Medicus KW - Homeostasis KW - Gene Deletion KW - Gene Expression Regulation, Bacterial KW - Escherichia coli K12 -- genetics KW - Manganese -- metabolism KW - Escherichia coli Proteins -- metabolism KW - Repressor Proteins -- metabolism KW - Repressor Proteins -- genetics KW - Membrane Transport Proteins -- metabolism KW - Membrane Transport Proteins -- genetics KW - Escherichia coli Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/898509015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=The+Escherichia+coli+MntR+miniregulon+includes+genes+encoding+a+small+protein+and+an+efflux+pump+required+for+manganese+homeostasis.&rft.au=Waters%2C+Lauren+S%3BSandoval%2C+Melissa%3BStorz%2C+Gisela&rft.aulast=Waters&rft.aufirst=Lauren&rft.date=2011-11-01&rft.volume=193&rft.issue=21&rft.spage=5887&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=1098-5530&rft_id=info:doi/10.1128%2FJB.05872-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-06 N1 - Date created - 2011-10-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 2006 Apr 7;125(1):71-84 [16615891] J Bacteriol. 2005 Oct;187(20):6962-71 [16199566] J Bacteriol. 2007 Mar;189(5):2101-9 [17172335] Biometals. 2007 Jun;20(3-4):485-99 [17216355] PLoS Biol. 2007 Apr;5(4):e92 [17373858] Cell. 2007 Sep 7;130(5):878-92 [17803910] Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20454-9 [18042713] BMC Genomics. 2007;8:347 [17908319] ISME J. 2008 Apr;2(4):393-403 [18273068] Mol Microbiol. 2008 Dec;70(5):1076-93 [18710431] Nat Rev Microbiol. 2009 Jan;7(1):25-35 [19079350] Mol Microbiol. 2008 Dec;70(6):1487-501 [19121005] Genes Dev. 2009 Feb 15;23(4):522-34 [19240136] Mol Microbiol. 2009 Apr;72(1):12-25 [19226324] Mol Microbiol. 2009 May;72(4):844-58 [19400769] Genes Dev. 2009 Nov 15;23(22):2650-62 [19933154] J Bacteriol. 2010 Jan;192(1):59-67 [19734312] J Bacteriol. 2010 Mar;192(5):1433-43 [19915021] Mol Microbiol. 2010 Feb;75(3):637-57 [20015147] PLoS One. 2010;5(9):e12570 [20838443] BMC Microbiol. 2010;10:319 [21156049] J Bacteriol. 2011 Mar;193(6):1477-80 [21239586] Biochemistry. 2011 Mar 15;50(10):1672-81 [21250660] Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5402-7 [21402925] Mol Microbiol. 2011 Apr;80(2):319-34 [21338418] Microbiology. 2001 Jul;147(Pt 7):1709-18 [11429449] Mol Microbiol. 2000 Mar;35(6):1454-68 [10760146] Proc Natl Acad Sci U S A. 2000 May 23;97(11):5978-83 [10811905] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5 [10829079] Mol Microbiol. 2000 Jun;36(5):1085-100 [10844693] Genes Dev. 2001 Jul 1;15(13):1637-51 [11445539] J Bacteriol. 2001 Aug;183(16):4806-13 [11466284] J Bacteriol. 2002 Jun;184(12):3151-8 [12029030] Mol Microbiol. 2002 Jun;44(5):1269-86 [12028379] Mol Microbiol. 2002 Jul;45(2):333-49 [12123448] Trends Microbiol. 2002 Nov;10(11):496-501 [12419613] Science. 2003 May 9;300(5621):931-6 [12738850] FEMS Microbiol Rev. 2003 Jun;27(2-3):263-90 [12829271] Nat Struct Biol. 2003 Aug;10(8):652-7 [12847518] Mol Microbiol. 2003 Sep;49(6):1477-91 [12950915] Biochemistry. 2003 Nov 4;42(43):12634-42 [14580210] Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6421-6 [15096624] J Proteome Res. 2004 May-Jun;3(3):463-8 [15253427] J Bacteriol. 2004 Oct;186(20):6698-705 [15466020] J Mol Biol. 1994 Feb 18;236(2):531-45 [8107138] Gene. 1995 May 26;158(1):9-14 [7789817] J Bacteriol. 1995 Jul;177(14):4121-30 [7608087] Science. 2004 Nov 5;306(5698):1025-8 [15459345] J Bacteriol. 2005 Feb;187(3):912-22 [15659669] J Bacteriol. 2005 Apr;187(8):2912-6 [15805538] Annu Rev Microbiol. 2006;60:187-209 [16704341] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JB.05872-11 ER - TY - JOUR T1 - Expression profiling of difficult-to-diagnose thyroid histologic subtypes shows distinct expression profiles and identify candidate diagnostic microRNAs. AN - 898503826; 21553140 AB - The incidence of thyroid cancer is increasing worldwide. The findings of up to 30% of thyroid fine-needle aspiration biopsies (FNAB) are inconclusive, primarily as a result of several thyroid histologic subtypes with overlapping cytologic features. MicroRNAs (miRNAs) are small noncoding RNAs and have been implicated in carcinogenesis. We hypothesized that there are miRNAs that are differentially expressed between benign and malignant thyroid tumors that are difficult to distinguish by FNAB. The expression of 1263 human miRNAs was profiled in 47 tumor samples representing difficult to diagnose histologic subtypes of thyroid neoplasm (21 benign, 26 malignant). Differentially expressed miRNAs were validated by quantitative real-time reverse transcriptase-polymerase chain reaction. The area under the receiver operating characteristic curve (AUC) was used to determine the diagnostic accuracy of differentially expressed miRNAs. Supervised hierarchical cluster analysis demonstrated grouping of 2 histologies (papillary and follicular thyroid carcinoma). A total of 34 miRNAs were differentially expressed in malignant compared to benign thyroid neoplasms (P0.7. miR-7 and miR-126 had the highest diagnostic accuracy with AUCs values of 0.81 and 0.77, respectively. To our knowledge, this is the first study to evaluate the diagnostic accuracy of miRNAs in thyroid histologies that are difficult to distinguish as benign or malignant by FNAB. miR-126 and miR-7 had high diagnostic accuracy and could be helpful adjuncts to thyroid FNAB. JF - Annals of surgical oncology AU - Kitano, Mio AU - Rahbari, Reza AU - Patterson, Erin E AU - Xiong, Yin AU - Prasad, Nijaguna B AU - Wang, Yongchun AU - Zeiger, Martha A AU - Kebebew, Electron AD - Endocrine Oncology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 3443 EP - 3452 VL - 18 IS - 12 KW - Biomarkers, Tumor KW - 0 KW - MicroRNAs KW - Index Medicus KW - Real-Time Polymerase Chain Reaction KW - Biopsy, Fine-Needle KW - ROC Curve KW - Oligonucleotide Array Sequence Analysis KW - Area Under Curve KW - Humans KW - Prognosis KW - Thyroid Neoplasms -- diagnosis KW - Gene Expression Profiling KW - Biomarkers, Tumor -- genetics KW - Thyroid Neoplasms -- classification KW - Thyroid Neoplasms -- genetics KW - MicroRNAs -- genetics KW - Adenocarcinoma, Follicular -- diagnosis KW - Adenocarcinoma, Follicular -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/898503826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+surgical+oncology&rft.atitle=Expression+profiling+of+difficult-to-diagnose+thyroid+histologic+subtypes+shows+distinct+expression+profiles+and+identify+candidate+diagnostic+microRNAs.&rft.au=Kitano%2C+Mio%3BRahbari%2C+Reza%3BPatterson%2C+Erin+E%3BXiong%2C+Yin%3BPrasad%2C+Nijaguna+B%3BWang%2C+Yongchun%3BZeiger%2C+Martha+A%3BKebebew%2C+Electron&rft.aulast=Kitano&rft.aufirst=Mio&rft.date=2011-11-01&rft.volume=18&rft.issue=12&rft.spage=3443&rft.isbn=&rft.btitle=&rft.title=Annals+of+surgical+oncology&rft.issn=1534-4681&rft_id=info:doi/10.1245%2Fs10434-011-1766-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-02-07 N1 - Date created - 2011-10-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Med Oncol. 2011 Dec;28(4):1054-7 [20680522] Biochem Biophys Res Commun. 2009 Feb 13;379(3):726-31 [19116145] Thyroid. 2011 Mar;21(3):243-51 [21190442] J Clin Endocrinol Metab. 2009 Jun;94(6):2092-8 [19318445] Thyroid. 2009 Jul;19(7):717-23 [19485775] Cancer. 2009 Jun 25;117(3):195-202 [19382174] Surg Clin North Am. 2009 Oct;89(5):1139-55 [19836489] Future Oncol. 2009 Oct;5(8):1283-93 [19852742] Lung Cancer. 2009 Nov;66(2):169-75 [19223090] Thyroid. 2009 Nov;19(11):1167-214 [19860577] Thyroid. 2009 Nov;19(11):1215-23 [19888859] J Clin Oncol. 2009 Dec 1;27(34):5848-56 [19884536] Curr Opin Oncol. 2010 Jan;22(1):23-9 [19907326] Thyroid. 2009 Dec;19(12):1351-61 [19895341] Br J Cancer. 2010 Jan 19;102(2):376-82 [20029416] Cancer Metastasis Rev. 2009 Dec;28(3-4):369-78 [20012925] Biochem Biophys Res Commun. 2010 Jan 15;391(3):1483-9 [20034472] Endocr Relat Cancer. 2010 Mar;17(1):F91-104 [19942715] Endocr Metab Immune Disord Drug Targets. 2010 Mar;10(1):47-56 [20088814] Biochem Biophys Res Commun. 2010 Apr 16;394(4):921-7 [20230785] Thyroid. 2010 May;20(5):489-94 [20406109] Otolaryngol Clin North Am. 2010 Apr;43(2):257-71, vii-viii [20510713] J Endocrinol Invest. 2010;33(5 Suppl):51-6 [20543551] Am J Surg. 2010 Jul;200(1):41-6 [20637335] Clin Oncol (R Coll Radiol). 2010 Aug;22(6):395-404 [20627675] Endocr Relat Cancer. 2010 Sep;17(3):835-46 [20621999] Med Clin North Am. 2010 Sep;94(5):1003-15 [20736109] Cancer Lett. 2010 Dec 1;298(1):50-63 [20619534] World J Surg. 2010 Nov;34(11):2589-94 [20703476] Biochem J. 2010 Nov 15;432(1):199-205 [20819078] Endocr Pract. 2003 Mar-Apr;9(2):128-36 [12917075] Am J Med. 1982 Sep;73(3):381-4 [7124765] Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19075-80 [16365291] Curr Opin Genet Dev. 2006 Feb;16(1):4-9 [16361094] Endocr Relat Cancer. 2006 Jun;13(2):497-508 [16728577] Oncogene. 2006 Oct 9;25(46):6163-9 [17028595] Nat Genet. 2007 May;39(5):582-3 [17460676] Clin Endocrinol (Oxf). 2007 May;66(5):678-83 [17381488] Endocr Relat Cancer. 2007 Sep;14(3):791-8 [17914108] Cancer. 2007 Oct 25;111(5):306-15 [17680588] Curr Opin Oncol. 2008 Jan;20(1):13-8 [18043251] Oncogene. 2007 Nov 29;26(54):7590-5 [17563749] Endocr Pathol. 2007 Fall;18(3):163-73 [18058265] Nature. 2008 Jan 10;451(7175):147-52 [18185580] J Clin Endocrinol Metab. 2008 May;93(5):1600-8 [18270258] Cancer Res. 2008 May 15;68(10):3566-72 [18483236] Diagn Cytopathol. 2008 Jun;36(6):390-9 [18478607] Mod Pathol. 2008 Sep;21(9):1139-46 [18587330] Thyroid. 2008 Sep;18(9):933-41 [18788917] Cancer Res. 2008 Oct 15;68(20):8195-200 [18922890] Biochem Biophys Res Commun. 2008 Dec 5;377(1):136-40 [18834857] J Clin Endocrinol Metab. 2008 Nov;93(11):4175-82 [18987277] Curr Opin Oncol. 2009 Jan;21(1):11-7 [19125013] Sci Signal. 2009 Jan 6;2(52):pe1 [19126861] Cancer Res. 2010 Nov 1;70(21):8822-31 [20978205] Cytopathology. 2010 Apr;21(2):75-85 [21054821] Cancer Lett. 2011 Jan 1;300(1):10-9 [20965651] J Clin Endocrinol Metab. 2010 Dec;95(12):5296-304 [20826580] Surgery. 2010 Dec;148(6):1170-6; discussion 1176-7 [21134548] Surgery. 2010 Dec;148(6):1294-9; discussion 1299-301 [21134564] Surgery. 2010 Dec;148(6):1313-5 [21134567] Cancer Sci. 2011 Jan;102(1):9-17 [20735434] Thyroid. 2011 Feb;21(2):111-8 [21275764] Clin Chem Lab Med. 2011 Feb;49(2):325-9 [21175381] Arch Pathol Lab Med. 2009 May;133(5):787-90 [19415954] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1245/s10434-011-1766-4 ER - TY - JOUR T1 - Liver toxicity and carcinogenicity in F344/N rats and B6C3F1 mice exposed to Kava Kava. AN - 898166827; 21871523 AB - Kava Kava is an herbal supplement used as an alternative to antianxiety drugs. Although some reports suggest an association of Kava Kava with hepatotoxicity , it continues to be used in the United States due to lack of toxicity characterization. In these studies F344/N rats and B6C3F1 mice were administered Kava Kava extract orally by gavage in corn oil for two weeks, thirteen weeks or two years. Results from prechronic studies administered Kava Kava at 0.125 to 2g/kg body weight revealed dose-related increases in liver weights and incidences of hepatocellular hypertrophy. In the chronic studies, there were dose-related increases in the incidences of hepatocellular hypertrophy in rats and mice administered Kava Kava for up to 1g/kg body weight. This was accompanied by significant increases in incidences of centrilobular fatty change. There was no treatment- related increase in carcinogenic activity in the livers of male or female rats in the chronic studies. Male mice showed a significant dose-related increase in the incidence of hepatoblastomas. In female mice, there was a significant increase in the combined incidence of hepatocellular adenoma and carcinoma in the low and mid dose groups but not in the high dose group. These findings were accompanied by several nonneoplastic hepatic lesions. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Behl, Mamta AU - Nyska, Abraham AU - Chhabra, Rajendra S AU - Travlos, Gregory S AU - Fomby, Laurene M AU - Sparrow, Barney R AU - Hejtmancik, Milton R AU - Chan, Po C AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 2820 EP - 2829 VL - 49 IS - 11 KW - Index Medicus KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Liver -- pathology KW - Drug Administration Schedule KW - Sex Characteristics KW - Dose-Response Relationship, Drug KW - Carcinogenicity Tests KW - Mice KW - Male KW - Female KW - Chemical and Drug Induced Liver Injury -- pathology KW - Kava -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/898166827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Liver+toxicity+and+carcinogenicity+in+F344%2FN+rats+and+B6C3F1+mice+exposed+to+Kava+Kava.&rft.au=Behl%2C+Mamta%3BNyska%2C+Abraham%3BChhabra%2C+Rajendra+S%3BTravlos%2C+Gregory+S%3BFomby%2C+Laurene+M%3BSparrow%2C+Barney+R%3BHejtmancik%2C+Milton+R%3BChan%2C+Po+C&rft.aulast=Behl&rft.aufirst=Mamta&rft.date=2011-11-01&rft.volume=49&rft.issue=11&rft.spage=2820&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2011.07.067 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-02-13 N1 - Date created - 2011-10-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cochrane Database Syst Rev. 2002;(2):CD003383 [12076477] Case Manager. 2002 Jul-Aug;13(4):26-8 [12131903] J Altern Complement Med. 2002 Jun;8(3):237-63 [12165183] Life Sci. 2002 Apr 19;70(22):2581-97 [12269386] Drug Metab Dispos. 2002 Nov;30(11):1153-7 [12386118] Lancet. 2002 Oct 26;360(9342):1336 [12414243] MMW Fortschr Med. 2002 Oct 10;144(41):40 [12474360] Planta Med. 2002 Dec;68(12):1055-8 [12494328] Cochrane Database Syst Rev. 2003;(1):CD003383 [12535473] J Clin Psychiatry. 2003 Feb;64(2):216-8 [12633134] Drug Metab Dispos. 2003 May;31(5):533-9 [12695340] Med J Aust. 2003 May 5;178(9):442-3 [12720510] J Toxicol Clin Toxicol. 2003;41(2):109-13 [12733846] Phytomedicine. 2003;10 Suppl 4:68-73 [12807347] J Hepatol. 2003 Jul;39(1):62-7 [12821045] Phytomedicine. 2003;10(5):440-6 [12834011] Planta Med. 2003 Jun;69(6):496-9 [12865965] Eur J Gastroenterol Hepatol. 2003 Sep;15(9):1033-6 [12923378] Phytochemistry. 2003 Oct;64(3):673-9 [13679089] CMAJ. 2003 Nov 25;169(11):1158-9 [14638649] CMAJ. 2003 Nov 25;169(11):1163-4 [14638650] Integr Cancer Ther. 2002 Sep;1(3):287-93; discussion 293 [14667286] J Toxicol Clin Toxicol. 2003;41(6):821-9 [14677792] Planta Med. 2003 Nov;69(11):971-2 [14735431] Med J Aust. 2004 Feb 16;180(4):198-9; author reply 199 [14960147] Planta Med. 2004 Mar;70(3):193-6 [15114493] Toxicol Pathol. 2004 Jul-Aug;32(4):393-401 [15307212] Biometrics. 1971 Mar;27(1):103-17 [5547548] Farmaco Prat. 1971 Nov;26(11):692-720 [5157783] Biometrics. 1977 Jun;33(2):386-9 [884197] Biometrics. 1986 Mar;42(1):183-6 [3719054] Biometrics. 1988 Jun;44(2):417-31 [3390507] Fundam Appl Toxicol. 1989 May;12(4):731-7 [2744275] Clin Exp Pharmacol Physiol. 1990 Jul;17(7):495-507 [2401103] Clin Exp Pharmacol Physiol. 1990 Jul;17(7):509-14 [2401104] Int J Biochem. 1990;22(9):997-1004 [1980896] J Ethnopharmacol. 1992 Aug;37(1):13-45 [1453702] J Am Acad Dermatol. 1994 Jul;31(1):89-97 [8021378] Toxicol Pathol. 1997 May-Jun;25(3):256-63 [9210256] Toxicol Sci. 1998 Mar;42(1):1-12 [9538042] Eur J Clin Pharmacol. 1998 Jul;54(5):431-5 [9754989] Pharmacogenomics J. 2005;5(1):6-13 [15492763] Planta Med. 2005 Feb;71(2):142-6 [15729622] Drugs. 2005;65(9):1239-82 [15916450] Geriatrics. 2005 Sep;60(9):24-5 [16153141] Drug Metab Dispos. 2005 Oct;33(10):1555-63 [16033948] Phytomedicine. 2006 Feb;13(3):205-8 [16428031] Exp Toxicol Pathol. 2007 Jan;58(4):223-36 [17059882] Altern Ther Health Med. 2007 Mar-Apr;13(2):22-9 [17405675] Toxicol Sci. 2007 May;97(1):214-21 [17329236] J Food Sci. 2007 Mar;72(2):C120-5 [17995826] Food Chem Toxicol. 2008 Jan;46(1):168-74 [17822821] World J Gastroenterol. 2008 Jan 28;14(4):541-6 [18203285] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008 Jan-Mar;26(1):89-112 [18322868] Eur J Gastroenterol Hepatol. 2008 Dec;20(12):1182-93 [18989142] Food Chem Toxicol. 2009 Feb;47(2):433-42 [19100306] Int J Toxicol. 2009 Nov-Dec;28(6 Suppl):175S-88S [19966149] Food Chem Toxicol. 2010 Feb;48(2):686-96 [19948201] Natl Toxicol Program Tech Rep Ser. 2012 Mar;(571):1-186 [22441424] J Clin Psychopharmacol. 2000 Feb;20(1):84-9 [10653213] J Clin Pharm Ther. 2000 Jun;25(3):197-220 [10886465] BMJ. 2001 Jan 20;322(7279):139 [11159570] Ann Intern Med. 2001 Jul 3;135(1):68-9 [11434754] Dtsch Med Wochenschr. 2001 Sep 7;126(36):970-2 [11544547] AWHONN Lifelines. 2002 Feb-Mar;6(1):13-5 [11971236] J Am Acad Child Adolesc Psychiatry. 2002 Jun;41(6):631-2 [12049436] Gastroenterol Hepatol. 2002 Jun-Jul;25(6):434-5 [12069710] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fct.2011.07.067 ER - TY - JOUR T1 - A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3. AN - 897812602; 21824976 AB - Genome-wide and candidate-gene association studies of bladder cancer have identified 10 susceptibility loci thus far. We conducted a meta-analysis of two previously published genome-wide scans (4501 cases and 6076 controls of European background) and followed up the most significant association signals [17 single nucleotide polymorphisms (SNPs) in 10 genomic regions] in 1382 cases and 2201 controls from four studies. A combined analysis adjusted for study center, age, sex, and smoking status identified a novel susceptibility locus that mapped to a region of 18q12.3, marked by rs7238033 (P = 8.7 × 10(-9); allelic odds ratio 1.20 with 95% CI: 1.13-1.28) and two highly correlated SNPs, rs10775480/rs10853535 (r(2)= 1.00; P = 8.9 × 10(-9); allelic odds ratio 1.16 with 95% CI: 1.10-1.22). The signal localizes to the solute carrier family 14 member 1 gene, SLC14A1, a urea transporter that regulates cellular osmotic pressure. In the kidney, SLC14A1 regulates urine volume and concentration whereas in erythrocytes it determines the Kidd blood groups. Our findings suggest that genetic variation in SLC14A1 could provide new etiological insights into bladder carcinogenesis. JF - Human molecular genetics AU - Garcia-Closas, Montserrat AU - Ye, Yuanqing AU - Rothman, Nathaniel AU - Figueroa, Jonine D AU - Malats, Núria AU - Dinney, Colin P AU - Chatterjee, Nilanjan AU - Prokunina-Olsson, Ludmila AU - Wang, Zhaoming AU - Lin, Jie AU - Real, Francisco X AU - Jacobs, Kevin B AU - Baris, Dalsu AU - Thun, Michael AU - De Vivo, Immaculata AU - Albanes, Demetrius AU - Purdue, Mark P AU - Kogevinas, Manolis AU - Kamat, Ashish M AU - Lerner, Seth P AU - Grossman, H Barton AU - Gu, Jian AU - Pu, Xia AU - Hutchinson, Amy AU - Fu, Yi-Ping AU - Burdett, Laurie AU - Yeager, Meredith AU - Tang, Wei AU - Tardón, Adonina AU - Serra, Consol AU - Carrato, Alfredo AU - García-Closas, Reina AU - Lloreta, Josep AU - Johnson, Alison AU - Schwenn, Molly AU - Karagas, Margaret R AU - Schned, Alan AU - Andriole, Gerald AU - Grubb, Robert AU - Black, Amanda AU - Jacobs, Eric J AU - Diver, W Ryan AU - Gapstur, Susan M AU - Weinstein, Stephanie J AU - Virtamo, Jarmo AU - Hunter, David J AU - Caporaso, Neil AU - Landi, Maria Teresa AU - Fraumeni, Joseph F AU - Silverman, Debra T AU - Chanock, Stephen J AU - Wu, Xifeng AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. montse.garciaclosas@icr.ac.uk Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 4282 EP - 4289 VL - 20 IS - 21 KW - Membrane Transport Proteins KW - 0 KW - urea transporter KW - Index Medicus KW - Risk Factors KW - Humans KW - Linkage Disequilibrium -- genetics KW - Polymorphism, Single Nucleotide -- genetics KW - Urinary Bladder Neoplasms -- genetics KW - Urinary Bladder Neoplasms -- mortality KW - Genetic Loci -- genetics KW - Chromosomes, Human, Pair 18 -- genetics KW - Genetic Predisposition to Disease KW - Membrane Transport Proteins -- genetics KW - Genome-Wide Association Study UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/897812602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+molecular+genetics&rft.atitle=A+genome-wide+association+study+of+bladder+cancer+identifies+a+new+susceptibility+locus+within+SLC14A1%2C+a+urea+transporter+gene+on+chromosome+18q12.3.&rft.au=Garcia-Closas%2C+Montserrat%3BYe%2C+Yuanqing%3BRothman%2C+Nathaniel%3BFigueroa%2C+Jonine+D%3BMalats%2C+N%C3%BAria%3BDinney%2C+Colin+P%3BChatterjee%2C+Nilanjan%3BProkunina-Olsson%2C+Ludmila%3BWang%2C+Zhaoming%3BLin%2C+Jie%3BReal%2C+Francisco+X%3BJacobs%2C+Kevin+B%3BBaris%2C+Dalsu%3BThun%2C+Michael%3BDe+Vivo%2C+Immaculata%3BAlbanes%2C+Demetrius%3BPurdue%2C+Mark+P%3BKogevinas%2C+Manolis%3BKamat%2C+Ashish+M%3BLerner%2C+Seth+P%3BGrossman%2C+H+Barton%3BGu%2C+Jian%3BPu%2C+Xia%3BHutchinson%2C+Amy%3BFu%2C+Yi-Ping%3BBurdett%2C+Laurie%3BYeager%2C+Meredith%3BTang%2C+Wei%3BTard%C3%B3n%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarc%C3%ADa-Closas%2C+Reina%3BLloreta%2C+Josep%3BJohnson%2C+Alison%3BSchwenn%2C+Molly%3BKaragas%2C+Margaret+R%3BSchned%2C+Alan%3BAndriole%2C+Gerald%3BGrubb%2C+Robert%3BBlack%2C+Amanda%3BJacobs%2C+Eric+J%3BDiver%2C+W+Ryan%3BGapstur%2C+Susan+M%3BWeinstein%2C+Stephanie+J%3BVirtamo%2C+Jarmo%3BHunter%2C+David+J%3BCaporaso%2C+Neil%3BLandi%2C+Maria+Teresa%3BFraumeni%2C+Joseph+F%3BSilverman%2C+Debra+T%3BChanock%2C+Stephen+J%3BWu%2C+Xifeng&rft.aulast=Garcia-Closas&rft.aufirst=Montserrat&rft.date=2011-11-01&rft.volume=20&rft.issue=21&rft.spage=4282&rft.isbn=&rft.btitle=&rft.title=Human+molecular+genetics&rft.issn=1460-2083&rft_id=info:doi/10.1093%2Fhmg%2Fddr342 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-31 N1 - Date created - 2011-10-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genetics. 2000 Jun;155(2):945-59 [10835412] Transfusion. 2011 Feb;51(2):380-92 [21309779] Pflugers Arch. 2004 Feb;447(5):603-9 [12856182] Nat Genet. 2004 Apr;36(4):388-93 [15052270] Genetics. 2004 Aug;167(4):2067-81 [15342541] Environ Health Perspect. 1979 Apr;29:71-9 [510245] Transfusion. 1982 Jan-Feb;22(1):70-1 [7064211] Am J Physiol. 1991 Apr;260(4 Pt 1):C778-83 [1902060] J Am Soc Nephrol. 1992 Jun;2(12):1689-96 [1498276] J Natl Cancer Inst. 1993 Jul 21;85(14):1159-64 [8320745] Epidemiology. 1994 Mar;5(2):218-25 [8172997] Lancet. 2005 Aug 20-26;366(9486):649-59 [16112301] Bioinformatics. 2006 Dec 15;22(24):3061-6 [17060358] Int J Epidemiol. 2007 Feb;36(1):23-8 [17510073] Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1595-600 [17684133] Am J Hum Genet. 2007 Sep;81(3):559-75 [17701901] Biostatistics. 2008 Oct;9(4):593-600 [18441336] Hum Mol Genet. 2008 Oct 15;17(R2):R122-8 [18852200] Nat Genet. 2008 Nov;40(11):1307-12 [18794855] Nat Genet. 2009 Feb;41(2):221-7 [19151717] Nat Genet. 2009 Sep;41(9):991-5 [19648920] Eur Urol. 2010 Feb;57(2):283-92 [19692168] Nat Genet. 2010 May;42(5):415-9 [20348956] Nat Genet. 2010 Jul;42(7):570-5 [20562874] Urol Oncol. 2010 Jul-Aug;28(4):409-28 [20610279] Nat Genet. 2010 Nov;42(11):978-84 [20972438] J Biol Chem. 2002 Mar 22;277(12):10633-7 [11792714] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/hmg/ddr342 ER - TY - JOUR T1 - A pilot safety trial investigating a vector-based vaccine targeting carcinoembryonic antigen in combination with radiotherapy in patients with gastrointestinal malignancies metastatic to the liver. AN - 896826905; 21871012 AB - Previous studies have demonstrated the ability of non-lethal doses of radiation to alter the phenotype of tumor cells to facilitate immune mediated killing. This pilot study evaluated the tolerability of a vector-based vaccine targeting carcinoembryonic antigen (CEA) in combination with radiation therapy in patients with gastrointestinal malignancies metastatic to the liver. Patients enrolled had progressive CEA(+) tumors with metastatic liver lesions. Patients had received a median of three previous chemotherapy regimens, with a median of 2 months since their last chemotherapy regimen. Only 58% had metastatic disease limited to the liver. Vaccination commenced day 1 with biweekly boosters and split-course radiation (total 32 Gy) starting on day 21. Blood was collected at baseline and day 91 for immunological analysis. A total of 12 patients were enrolled. There were no grade 3 or greater toxicities or grade 2 or greater hepatic toxicities. Median time on-study was 3 months, with the longest time on treatment being 5 months (n = 2). Immunological analysis was limited to two patients; neither showed an increase above baseline in CEA-specific T cells post-therapy. CEA/TRICOM vaccination in combination with low-dose radiation therapy is safe. There was limited evidence of activity in this patient population. JF - Expert opinion on biological therapy AU - Gulley, James L AU - Madan, Ravi A AU - Tsang, Kwong-Yok AU - Arlen, Philip M AU - Camphausen, Kevin AU - Mohebtash, Mahsa AU - Kamrava, Mitchell AU - Schlom, Jeffrey AU - Citrin, Deborah AD - National Cancer Institute, National Institutes of Health, Center for Cancer Research, Laboratory of Tumor Immunology and Biology, 10 Center Dr, 8B09 MSC 1750, Bethesda, MD 20892, USA. gulleyj@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 1409 EP - 1418 VL - 11 IS - 11 KW - Cancer Vaccines KW - 0 KW - Carcinoembryonic Antigen KW - Vaccines, Synthetic KW - Index Medicus KW - United States KW - Radiation Dosage KW - Radiotherapy, Adjuvant KW - National Cancer Institute (U.S.) KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Pilot Projects KW - Middle Aged KW - Vaccines, Synthetic -- therapeutic use KW - Time Factors KW - Male KW - Liver Neoplasms -- radiotherapy KW - Rectal Neoplasms -- therapy KW - Colonic Neoplasms -- genetics KW - Cancer Vaccines -- adverse effects KW - Carcinoembryonic Antigen -- immunology KW - Fowlpox virus -- genetics KW - Cancer Vaccines -- therapeutic use KW - Rectal Neoplasms -- pathology KW - Liver Neoplasms -- secondary KW - Colonic Neoplasms -- immunology KW - Rectal Neoplasms -- genetics KW - Rectal Neoplasms -- immunology KW - Colonic Neoplasms -- radiotherapy KW - Rectal Neoplasms -- radiotherapy KW - Liver Neoplasms -- therapy KW - Colonic Neoplasms -- therapy KW - Genetic Vectors KW - Colonic Neoplasms -- pathology KW - Carcinoembryonic Antigen -- genetics KW - Radiotherapy, Conformal -- adverse effects KW - Liver Neoplasms -- immunology KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896826905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+biological+therapy&rft.atitle=A+pilot+safety+trial+investigating+a+vector-based+vaccine+targeting+carcinoembryonic+antigen+in+combination+with+radiotherapy+in+patients+with+gastrointestinal+malignancies+metastatic+to+the+liver.&rft.au=Gulley%2C+James+L%3BMadan%2C+Ravi+A%3BTsang%2C+Kwong-Yok%3BArlen%2C+Philip+M%3BCamphausen%2C+Kevin%3BMohebtash%2C+Mahsa%3BKamrava%2C+Mitchell%3BSchlom%2C+Jeffrey%3BCitrin%2C+Deborah&rft.aulast=Gulley&rft.aufirst=James&rft.date=2011-11-01&rft.volume=11&rft.issue=11&rft.spage=1409&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+biological+therapy&rft.issn=1744-7682&rft_id=info:doi/10.1517%2F14712598.2011.615741 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-02-01 N1 - Date created - 2011-10-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cancer Res. 1999 Nov 15;59(22):5800-7 [10582702] Semin Radiat Oncol. 2005 Oct;15(4):279-83 [16183482] Int J Cancer. 2000 Sep 1;87(5):680-7 [10925362] J Clin Oncol. 2000 Dec 1;18(23):3964-73 [11099326] Hum Pathol. 2000 Nov;31(11):1357-62 [11112209] Clin Cancer Res. 2001 May;7(5):1181-91 [11350882] Cancer Res. 2001 Jun 1;61(11):4497-505 [11389081] J Immunol. 2001 Aug 1;167(3):1137-40 [11466326] Br J Cancer. 2002 Feb 1;86(3):417-23 [11875709] Cancer Immunol Immunother. 2006 Mar;55(3):268-76 [16034561] Expert Opin Pharmacother. 2006 Aug;7(11):1475-86 [16859431] Curr Cancer Drug Targets. 2007 Feb;7(1):31-40 [17305476] Clin Cancer Res. 2007 Nov 1;13(21):6247-51 [17975134] Clin Cancer Res. 2008 Feb 15;14(4):1032-40 [18281535] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Clin Cancer Res. 2008 May 15;14(10):3060-9 [18483372] Clin Cancer Res. 2008 Jul 15;14(14):4526-31 [18628467] Clin Cancer Res. 2008 Aug 15;14(16):5284-91 [18698048] Oncology (Williston Park). 2008 Aug;22(9):1064-70; discussion 1075, 1080-1, 1084 [18777956] Curr Opin Mol Ther. 2009 Feb;11(1):37-42 [19169958] J Clin Oncol. 2009 Apr 1;27(10):1572-8 [19255321] Cancer Immunol Immunother. 2010 May;59(5):663-74 [19890632] Hum Gene Ther. 2009 Feb;20(2):125-36 [18937552] J Natl Cancer Inst. 2010 Sep 22;102(18):1388-97 [20826737] Neoplasia. 2002 Mar-Apr;4(2):151-63 [11896570] J Immunol. 2002 May 1;168(9):4272-6 [11970966] Anticancer Res. 2002 Jul-Aug;22(4):2437-42 [12174940] Clin Cancer Res. 2002 Oct;8(10):3219-25 [12374692] Cancer Res. 2002 Oct 15;62(20):5770-7 [12384537] Cancer Res. 2002 Dec 1;62(23):6944-51 [12460911] Vaccine. 2003 Dec 12;22(2):224-36 [14615150] Eur J Immunol. 2004 Feb;34(2):336-44 [14768038] Expert Opin Biol Ther. 2004 Apr;4(4):575-88 [15102606] Cancer Res. 2004 Jun 15;64(12):4328-37 [15205348] J Nucl Med. 1987 Apr;28(4):495-504 [3572535] Cell. 1989 Apr 21;57(2):327-34 [2702691] Arch Surg. 1990 Mar;125(3):300-4 [2407225] Int J Cancer. 1993 Apr 1;53(6):892-7 [8386136] Ann N Y Acad Sci. 1993 Aug 12;690:370-3 [8368759] J Natl Cancer Inst. 1995 Jul 5;87(13):982-90 [7629885] Vaccine. 1997 Apr-May;15(6-7):759-68 [9178479] Cancer Res. 1997 Oct 15;57(20):4570-7 [9377571] Cancer Res. 1999 Feb 1;59(3):676-83 [9973217] Cancer Res. 2004 Nov 1;64(21):7985-94 [15520206] J Clin Oncol. 2005 Feb 1;23(4):720-31 [15613691] Clin Cancer Res. 2005 May 1;11(9):3353-62 [15867235] J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1517/14712598.2011.615741 ER - TY - JOUR T1 - Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury. AN - 896526626; 21884784 AB - Cisplatin is a commonly used chemotherapeutic drug, the clinical use of which is limited by the development of dose-dependent nephrotoxicity. Enhanced inflammatory response, oxidative stress, and cell death have been implicated in the development of cisplatin-induced nephropathy; however, the precise mechanisms are elusive. Overactivation of the nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) by oxidative DNA damage under various pathological conditions promotes cell death and up-regulation of key proinflammatory pathways. In this study, using a well-established model of nephropathy, we have explored the role of PARP-1 in cisplatin-induced kidney injury. Genetic deletion or pharmacological inhibition of PARP-1 markedly attenuated the cisplatin-induced histopathological damage, impaired renal function (elevated serum BUN and creatinine levels), and enhanced inflammatory response (leukocyte infiltration; TNF-α, IL-1β, F4/80, adhesion molecules ICAM-1/VCAM-1 expression) and consequent oxidative/nitrative stress (4-HNE, 8-OHdG, and nitrotyrosine content; NOX2/NOX4 expression). PARP inhibition also facilitated the cisplatin-induced death of cancer cells. Thus, PARP activation plays an important role in cisplatin-induced kidney injury, and its pharmacological inhibition may represent a promising approach to preventing the cisplatin-induced nephropathy. This is particularly exciting because several PARP inhibitors alone or in combination with DNA-damaging anticancer agents show considerable promise in clinical trials for treatment of various malignancies (e.g., triple-negative breast cancer). Published by Elsevier Inc. JF - Free radical biology & medicine AU - Mukhopadhyay, Partha AU - Horváth, Béla AU - Kechrid, Malek AU - Tanchian, Galin AU - Rajesh, Mohanraj AU - Naura, Amarjit S AU - Boulares, A Hamid AU - Pacher, Pál AD - Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 1774 EP - 1788 VL - 51 IS - 9 KW - Parp1 protein, mouse KW - EC 2.4.2.30 KW - Poly (ADP-Ribose) Polymerase-1 KW - Poly(ADP-ribose) Polymerases KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Mice KW - Male KW - Mice, Knockout KW - Cisplatin -- toxicity KW - Acute Kidney Injury -- chemically induced KW - Inflammation -- chemically induced KW - Inflammation -- metabolism KW - Poly(ADP-ribose) Polymerases -- metabolism KW - Poly(ADP-ribose) Polymerases -- deficiency KW - Acute Kidney Injury -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896526626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Poly%28ADP-ribose%29+polymerase-1+is+a+key+mediator+of+cisplatin-induced+kidney+inflammation+and+injury.&rft.au=Mukhopadhyay%2C+Partha%3BHorv%C3%A1th%2C+B%C3%A9la%3BKechrid%2C+Malek%3BTanchian%2C+Galin%3BRajesh%2C+Mohanraj%3BNaura%2C+Amarjit+S%3BBoulares%2C+A+Hamid%3BPacher%2C+P%C3%A1l&rft.aulast=Mukhopadhyay&rft.aufirst=Partha&rft.date=2011-11-01&rft.volume=51&rft.issue=9&rft.spage=1774&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=1873-4596&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2011.08.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-27 N1 - Date created - 2011-10-05 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Am Coll Cardiol. 2010 Dec 14;56(25):2115-25 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Nat Rev Drug Discov. 2005 Apr;4(4):307-20 [15789122] Nat Rev Drug Discov. 2005 May;4(5):421-40 [15864271] Pharmacol Res. 2005 Jul;52(1):60-71 [15911334] Pharmacol Res. 2005 Jul;52(1):109-18 [15911339] Curr Vasc Pharmacol. 2005 Jul;3(3):293-9 [16026325] Int J Mol Med. 2006 Feb;17(2):369-75 [16391839] J Am Soc Nephrol. 2006 Mar;17(3):765-74 [16481417] Nephrol Dial Transplant. 2006 Aug;21(8):2085-95 [16705027] Biochem Biophys Res Commun. 2006 Nov 17;350(2):352-7 [17007818] Biochem Biophys Res Commun. 2006 Dec 1;350(4):1056-62 [17046715] Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18314-9 [17116881] Physiol Rev. 2007 Jan;87(1):315-424 [17237348] Circulation. 2007 May 8;115(18):2442-50 [17438151] Nat Rev Drug Discov. 2007 Aug;6(8):662-80 [17667957] Nat Protoc. 2007;2(9):2295-301 [17853886] Eur J Cancer. 2007 Sep;43(14):2124-33 [17714938] Curr Opin Investig Drugs. 2007 Dec;8(12):1051-6 [18058575] Free Radic Biol Med. 2008 Mar 15;44(6):972-81 [17976390] Kidney Int. 2008 May;73(9):994-1007 [18272962] J Am Soc Nephrol. 2008 May;19(5):923-32 [18256356] Int J Mol Med. 2008 Jul;22(1):113-8 [18575783] Arch Biochem Biophys. 2008 Sep 15;477(2):183-95 [18602883] J Pharmacol Exp Ther. 2009 Mar;328(3):708-14 [19074681] Front Biosci (Landmark Ed). 2009;14:1116-28 [19273119] Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1778-90 [19098320] Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1466-83 [19286953] J Clin Invest. 2009 May;119(5):1275-85 [19349686] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Apr;27(2):120-39 [19412858] J Am Soc Nephrol. 2009 Jun;20(6):1323-32 [19423693] Free Radic Biol Med. 2009 Jul 1;47(1):13-26 [19362586] N Engl J Med. 2009 Jul 9;361(2):123-34 [19553641] Kidney Int. 2009 Aug;76(3):277-85 [19436334] J Am Soc Nephrol. 2010 Jan;21(1):53-63 [19875815] Biochem Pharmacol. 2010 Apr 1;79(7):1007-14 [19945439] Free Radic Biol Med. 2010 Feb 1;48(3):457-67 [19969072] Nat Rev Cancer. 2010 Apr;10(4):293-301 [20200537] J Clin Oncol. 2010 May 20;28(15):2512-9 [20406929] Br J Pharmacol. 2010 Jun;160(3):657-68 [20590569] Lancet. 2010 Jul 24;376(9737):235-44 [20609467] Lancet. 2010 Jul 24;376(9737):245-51 [20609468] Biochim Biophys Acta. 2010 Nov;1802(11):1020-7 [20621183] J Am Soc Nephrol. 2010 Oct;21(10):1702-12 [20705711] J Immunol. 2010 Oct 15;185(8):4904-11 [20844196] Cancer Res. 2010 Oct 15;70(20):7970-80 [20798217] Int J Cancer. 2011 Jan 15;128(2):251-65 [20853319] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2011.08.006 ER - TY - JOUR T1 - Biomarkers of Oxidative Stress Study IV: ozone exposure of rats and its effect on antioxidants in plasma and bronchoalveolar lavage fluid. AN - 896524736; 21824516 AB - The objective of this study was to determine whether acutely exposing rats to ozone would result in the loss of antioxidants from plasma and bronchoalveolar lavage fluid (BALF). Additional goals were to compare analyses of the same antioxidant concentration between different laboratories, to investigate which methods have the sensitivity to detect decreased levels of antioxidants, and to identify a reliable measure of oxidative stress in ozone-exposed rats. Male Fisher rats were exposed to either 2.0 or 5.0 ppm ozone inhalation for 2h. Blood plasma and BALF samples were collected 2, 7, and 16 h after the exposure. It was found that ascorbic acid in plasma collected from rats after the higher dose of ozone was lower at 2h, but not later. BALF concentrations of ascorbic acid were decreased at both 2 and 7h postexposure. Tocopherols (α, δ, γ), 5-nitro-γ-tocopherol, tocol, glutathione (GSH/GSSG), and cysteine (Cys/CySS) were not decreased, regardless of the dose or postexposure time point used for sample collection. Uric acid was significantly increased by the low dose at 2h and the high dose at the 7h point, probably because of the accumulation of blood plasma in the lung from ozone-increased alveolar capillary permeability. We conclude that measurements of antioxidants in plasma are not sensitive biomarkers for oxidative damage induced by ozone and are not a useful choice for the assessment of oxidative damage by ozone in vivo. Published by Elsevier Inc. JF - Free radical biology & medicine AU - Kadiiska, Maria B AU - Hatch, Gary E AU - Nyska, Abraham AU - Jones, Dean P AU - Hensley, Kenneth AU - Stocker, Roland AU - George, Magdalene M AU - Van Thiel, David H AU - Stadler, Krisztian AU - Barrett, J Carl AU - Mason, Ronald P AD - Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Kadiiska@niehs.nih.gov Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 1636 EP - 1642 VL - 51 IS - 9 KW - Antioxidants KW - 0 KW - Biomarkers KW - Uric Acid KW - 268B43MJ25 KW - Ozone KW - 66H7ZZK23N KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Dose-Response Relationship, Drug KW - Ascorbic Acid -- blood KW - Administration, Inhalation KW - Time Factors KW - Biomarkers -- blood KW - Uric Acid -- blood KW - Male KW - Antioxidants -- analysis KW - Antioxidants -- metabolism KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Ozone -- pharmacology KW - Oxidative Stress -- drug effects KW - Ozone -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896524736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Biomarkers+of+Oxidative+Stress+Study+IV%3A+ozone+exposure+of+rats+and+its+effect+on+antioxidants+in+plasma+and+bronchoalveolar+lavage+fluid.&rft.au=Kadiiska%2C+Maria+B%3BHatch%2C+Gary+E%3BNyska%2C+Abraham%3BJones%2C+Dean+P%3BHensley%2C+Kenneth%3BStocker%2C+Roland%3BGeorge%2C+Magdalene+M%3BVan+Thiel%2C+David+H%3BStadler%2C+Krisztian%3BBarrett%2C+J+Carl%3BMason%2C+Ronald+P&rft.aulast=Kadiiska&rft.aufirst=Maria&rft.date=2011-11-01&rft.volume=51&rft.issue=9&rft.spage=1636&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=1873-4596&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2011.07.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-27 N1 - Date created - 2011-10-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am Rev Respir Dis. 1989 Feb;139(2):407-15 [2913889] Proc Natl Acad Sci U S A. 1988 Dec;85(24):9748-52 [3200852] Free Radic Res Commun. 1990;9(1):1-32 [2159941] J Lipid Res. 1990 Apr;31(4):675-85 [2351872] J Lipid Res. 1990 Apr;31(4):687-94 [2351873] Am J Physiol. 1990 Jun;258(6 Pt 1):L313-20 [2360644] Free Radic Biol Med. 1990;9(3):245-65 [2272533] Exp Lung Res. 1991 May-Jun;17(3):547-58 [1860453] FEBS Lett. 1992 Feb 24;298(2-3):269-72 [1544461] Toxicol Appl Pharmacol. 1992 May;114(1):41-6 [1316646] Toxicol Appl Pharmacol. 1992 Jun;114(2):268-76 [1609419] Biochem J. 1992 Dec 1;288 ( Pt 2):341-4 [1463440] Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):45-9 [8419943] Am Rev Respir Dis. 1993 Mar;147(3):753-60 [8442612] Environ Health Perspect. 1993 Dec;101 Suppl 4:219-24 [8206036] Am J Physiol. 1994 Jun;266(6 Pt 1):L612-9 [8023949] Free Radic Biol Med. 1994 Nov;17(5):451-65 [7835752] Toxicol Lett. 1995 Dec;82-83:287-93 [8597067] Toxicol Lett. 1995 Dec;82-83:295-300 [8597068] Toxicol Appl Pharmacol. 1996 Sep;140(1):1-12 [8806864] Exp Lung Res. 1996 Jul-Aug;22(4):435-48 [8872087] Am J Physiol. 1996 Oct;271(4 Pt 1):L555-65 [8897902] Free Radic Res. 1996 Dec;25(6):475-88 [8951421] Toxicol Appl Pharmacol. 1996 Dec;141(2):416-24 [8975766] Am J Respir Cell Mol Biol. 1997 Dec;17(6):740-7 [9409561] J Inflamm. 1998;48(2):56-66 [9656142] Clin Chim Acta. 1998 Jul 28;275(2):175-84 [9721075] J Toxicol Environ Health B Crit Rev. 1999 Jan-Mar;2(1):31-86 [10081525] FASEB J. 1999 Jun;13(9):995-1006 [10336882] Eur Respir J. 1999 Jun;13(6):1429-38 [10445623] Free Radic Biol Med. 2005 Feb 15;38(4):515-26 [15649654] Biochem Pharmacol. 2005 Aug 1;70(3):343-54 [15963955] Methods Enzymol. 2005;396:171-82 [16291232] Clin Chem. 2006 Apr;52(4):601-23 [16484333] Proc Am Thorac Soc. 2007 Jul;4(3):240-6 [17607006] Am J Respir Cell Mol Biol. 2009 Jan;40(1):90-8 [18664641] Free Radic Biol Med. 2009 Mar 1;46(5):531-42 [19111608] Free Radic Biol Med. 2009 Nov 15;47(10):1329-38 [19715755] Mol Nutr Food Res. 2010 May;54(5):601-15 [20169582] Free Radic Biol Med. 2000 Mar 15;28(6):838-45 [10802213] Free Radic Biol Med. 2001 Mar 1;30(5):456-62 [11182517] Mutat Res. 2001 Apr 18;475(1-2):29-35 [11295151] Free Radic Biol Med. 2004 Mar 1;36(5):673-81 [14980710] Am J Respir Crit Care Med. 2004 Mar 15;169(6):726-32 [14701711] Proc Natl Acad Sci U S A. 1981 Nov;78(11):6858-62 [6947260] Am Rev Respir Dis. 1983 Jun;127(6):686-90 [6859651] Am Rev Respir Dis. 1984 Aug;130(2):214-9 [6465675] J Free Radic Biol Med. 1985;1(2):117-24 [3836238] Am J Clin Nutr. 1987 Apr;45(4):693-703 [3565296] Arch Biochem Biophys. 1987 Nov 15;259(1):224-5 [3688884] Anal Biochem. 1987 Nov 1;166(2):424-30 [3434782] Am Rev Respir Dis. 1989 Aug;140(2):493-501 [2527482] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2011.07.013 ER - TY - JOUR T1 - Preserved learning and memory following 5-fluorouracil and cyclophosphamide treatment in rats. AN - 895854861; 21875615 AB - Some patients experience enduring cognitive impairment after cancer treatment, a condition termed "chemofog". Animal models allow assessment of chemotherapy effects on learning and memory per se, independent of changes due to cancer itself or associated health consequences such as depression. The present study examined the long-term learning and memory effects of a chemotherapy cocktail used widely in the treatment of breast cancer, consisting of 5-fluorouracil (5FU) and cyclophosphamide (CYP). Eighty 5-month old male F344 rats received contextual and cued fear conditioning before treatment with saline, or a low or high dose drug cocktail (50mg/kg CYP and 75 mg/kg 5FU, or 75 mg/kg CYP and 120 mg/kg 5FU, i.p., respectively) every 30 days for 2 months. After a 2-month, no-drug recovery, both long-term retention and new task acquisition in the water maze and 14-unit T-maze were assessed. Neither dose of the CYP/5FU cocktail impaired retrograde fear memory despite marked toxicity documented by enduring weight loss and 50% mortality at the higher dose. Acquisition in the water maze and Stone maze was also normal relative to controls in rats treated with CYP/5FU. The results contribute to a growing literature suggesting that learning and memory mediated by the hippocampus can be relatively resistant to chemotherapy. Future investigation may need to focus on assessments of processing speed, executive function and attention, and the possible interactive contribution of cancer itself and aging to the post-treatment development of cognitive impairment. Copyright © 2011 Elsevier Inc. All rights reserved. JF - Pharmacology, biochemistry, and behavior AU - Long, Jeffrey M AU - Lee, Garrick D AU - Kelley-Bell, Bennett AU - Spangler, Edward L AU - Perez, Evelyn J AU - Longo, Dan L AU - de Cabo, Rafael AU - Zou, Sige AU - Rapp, Peter R AD - Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA. longjm@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 205 EP - 211 VL - 100 IS - 1 KW - Cyclophosphamide KW - 8N3DW7272P KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Rats KW - Fluorouracil -- administration & dosage KW - Cyclophosphamide -- administration & dosage KW - Fluorouracil -- adverse effects KW - Animals KW - Rats, Inbred F344 KW - Learning -- physiology KW - Treatment Outcome KW - Learning -- drug effects KW - Cognition Disorders -- chemically induced KW - Male KW - Cyclophosphamide -- adverse effects KW - Memory -- drug effects KW - Memory -- physiology KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/895854861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Preserved+learning+and+memory+following+5-fluorouracil+and+cyclophosphamide+treatment+in+rats.&rft.au=Long%2C+Jeffrey+M%3BLee%2C+Garrick+D%3BKelley-Bell%2C+Bennett%3BSpangler%2C+Edward+L%3BPerez%2C+Evelyn+J%3BLongo%2C+Dan+L%3Bde+Cabo%2C+Rafael%3BZou%2C+Sige%3BRapp%2C+Peter+R&rft.aulast=Long&rft.aufirst=Jeffrey&rft.date=2011-11-01&rft.volume=100&rft.issue=1&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=1873-5177&rft_id=info:doi/10.1016%2Fj.pbb.2011.08.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-07-23 N1 - Date created - 2011-09-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Breast. 2007 Dec;16 Suppl 2:S166-8 [17719225] Behav Brain Res. 2008 Jan 25;186(2):168-75 [17854921] Ann Oncol. 2008 Apr;19(4):623-9 [17974553] Psychopharmacology (Berl). 2008 Sep;199(4):527-38 [18463849] Ann Oncol. 2002 Sep;13(9):1387-97 [12196364] J Lab Clin Med. 2002 Nov;140(5):358-68 [12434138] Can J Physiol Pharmacol. 2002 Nov;80(11):1076-84 [12489927] J Int Neuropsychol Soc. 2003 Nov;9(7):967-82 [14738279] Science. 2004 May 7;304(5672):881-3 [15131309] Cancer. 2004 Jun 1;100(11):2292-9 [15160331] J Clin Oncol. 2004 Jun 1;22(11):2233-9 [15169812] Neurobiol Learn Mem. 2004 Nov;82(3):171-7 [15464402] Nature. 1982 Jun 24;297(5868):681-3 [7088155] Neurobiol Aging. 1988 Sep-Dec;9(5-6):475-85 [3062459] Physiol Behav. 1990 Jan;47(1):207-12 [2326338] Neurobiol Aging. 1995 Jan-Feb;16(1):85-9 [7723940] Physiol Behav. 1996 Jan;59(1):153-6 [8848475] Brain Cogn. 2005 Oct;59(1):60-70 [15975700] J Clin Oncol. 2005 Nov 1;23(31):8025-32 [16258100] Cancer. 2005 Nov 15;104(10):2222-33 [16206292] Clin Cancer Res. 2006 Jan 1;12(1):198-205 [16397043] Clin Neuropsychol. 2006 Feb;20(1):76-89 [16410227] Ann Oncol. 2006 Mar;17(3):415-23 [16357023] Br J Cancer. 2006 Mar 27;94(6):828-34 [16523200] Learn Mem. 2006 Jul-Aug;13(4):451-7 [16882861] Clin Cancer Res. 2006 Aug 15;12(16):5000; author reply 5000-1 [16914590] J Clin Oncol. 2006 Nov 10;24(32):5132-7 [17093275] Pharmacol Biochem Behav. 2006 Sep;85(1):66-75 [16935324] Cancer. 2007 May 1;109(9):1905-13 [17351951] Behav Brain Res. 2007 Jul 19;181(1):168-72 [17509697] Eur J Neurosci. 2008 Jul;28(2):323-30 [18702703] Metab Brain Dis. 2008 Sep;23(3):325-33 [18690526] Cancer. 2008 Nov 1;113(9):2431-9 [18823033] Neuroscience. 2008 Nov 11;157(1):95-104 [18835334] Behav Brain Res. 2009 Aug 12;201(2):279-84 [19428645] South Med J. 2009 Sep;102(9):929-34 [19668023] Pharmacol Biochem Behav. 2009 Dec;94(2):239-43 [19747935] Behav Brain Res. 2010 May 1;209(1):66-72 [20096731] Cancer. 2010 Jul 15;116(14):3348-56 [20564075] Pharmacol Biochem Behav. 2010 Dec;97(2):333-9 [20828582] Brain Res Bull. 2008 Nov 25;77(5):237-40 [18755251] Neurosci Biobehav Rev. 2011 Jan;35(3):729-41 [20869395] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.pbb.2011.08.012 ER - TY - JOUR T1 - Intranasal Administration of Adeno-associated Virus Type 12 (AAV12) Leads to Transduction of the Nasal Epithelia and Can Initiate Transgene-specific Immune Response AN - 1668268795; PQ0001244374 AB - A critical aspect in defining the utility of a vector for gene therapy applications is the cell tropism and biodistribution of the vector. Adeno-associated virus type 12 (AAV12) has several unique biological and immunological properties that could be exploited for gene therapy purposes, including a unique cell surface receptor, transduction of epithelial cells, and limited neutralization by pooled human antibodies. However, little is known about its cell tropism and biodistribution in vivo. In vivo biodistribution studies with AAV12 vectors encoding a cytomegalovirus promoted luciferase transgene indicated preferential transduction of the nasal epithelia which was not observed with AAV2-based vectors. Expression peaked 2 weeks postadministration, before decreasing to a persistent level. The level of neutralizing antibodies (Nab) induced was sevenfold lower for AAV12 than for AAV2, an advantage for use in repeat administration. Furthermore, vectors encoding influenza A nucleoprotein (NP), an antigen which has previously been shown to induce immune protection against challenge, resulted in generation of both anti-A/NP antibodies and lung anti-A/NP T cells. Our findings suggest further evaluation of AAV12 as a vector for gene therapy and as a potential nasal vaccine. JF - Molecular Therapy AU - Quinn, Kathrina AU - Quirion, Mary R AU - Lo, Chia-Yun AU - Misplon, Julia A AU - Epstein, Suzanne L AU - Chiorini, John A AD - Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA, jchiorini@dir.nidcr.nih.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1990 EP - 1998 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 19 IS - 11 SN - 1525-0016, 1525-0016 KW - Genetics Abstracts; Virology & AIDS Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Cell surface KW - Epithelial cells KW - Receptor mechanisms KW - Gene therapy KW - Influenza A KW - Nucleoproteins KW - Tropism KW - Transgenes KW - Cytomegalovirus KW - Adeno-associated virus KW - Expression vectors KW - Antibodies KW - Intranasal administration KW - Lung KW - Lymphocytes T KW - Immune response KW - Vaccines KW - W 30905:Medical Applications KW - V 22350:Immunology KW - G 07730:Development & Cell Cycle KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668268795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=Intranasal+Administration+of+Adeno-associated+Virus+Type+12+%28AAV12%29+Leads+to+Transduction+of+the+Nasal+Epithelia+and+Can+Initiate+Transgene-specific+Immune+Response&rft.au=Quinn%2C+Kathrina%3BQuirion%2C+Mary+R%3BLo%2C+Chia-Yun%3BMisplon%2C+Julia+A%3BEpstein%2C+Suzanne+L%3BChiorini%2C+John+A&rft.aulast=Quinn&rft.aufirst=Kathrina&rft.date=2011-11-01&rft.volume=19&rft.issue=11&rft.spage=1990&rft.isbn=&rft.btitle=&rft.title=Molecular+Therapy&rft.issn=15250016&rft_id=info:doi/10.1038%2Fmt.2011.146 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Cell surface; Gene therapy; Receptor mechanisms; Influenza A; Transgenes; Tropism; Nucleoproteins; Expression vectors; Antibodies; Intranasal administration; Lung; Lymphocytes T; Vaccines; Immune response; Cytomegalovirus; Adeno-associated virus DO - http://dx.doi.org/10.1038/mt.2011.146 ER - TY - JOUR T1 - Personalized Cell Transfer Immunotherapy for B-Cell Malignancies and Solid Cancers AN - 1668249000; PQ0001244366 AB - Two independent groups have now corroborated and extended our earlier report[1] that the administration of autologous cells transduced with a chimeric antigen receptor (CAR) targeting the CD19 molecule could eradicate CD19 super(+) B-lineage cells in humans and was associated with the regression of advanced follicular lymphoma.[2-4] These studies have opened opportunities to tailor the genetic modification of autologous lymphocytes with receptors suitable for antigens presented on a patient's unique cancer and thus personalize cancer immunotherapy. JF - Molecular Therapy AU - Rosenberg, Steven A AU - Kochenderfer, James N AD - Surgery Branch, National Cancer Institute, National Institutes of Health, CRC-10, 10 Center Drive, Room 3-3940, Bethesda, Maryland 20892, USA, sar@nih.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1928 EP - 1930 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 19 IS - 11 SN - 1525-0016, 1525-0016 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Malignancy KW - Lymphocytes B KW - Immunotherapy KW - Lymphocytes KW - Cancer KW - CD19 antigen KW - F 06960:Molecular Immunology KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668249000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=Personalized+Cell+Transfer+Immunotherapy+for+B-Cell+Malignancies+and+Solid+Cancers&rft.au=Rosenberg%2C+Steven+A%3BKochenderfer%2C+James+N&rft.aulast=Rosenberg&rft.aufirst=Steven&rft.date=2011-11-01&rft.volume=19&rft.issue=11&rft.spage=1928&rft.isbn=&rft.btitle=&rft.title=Molecular+Therapy&rft.issn=15250016&rft_id=info:doi/10.1038%2Fmt.2011.223 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Malignancy; Lymphocytes B; Immunotherapy; Lymphocytes; Cancer; CD19 antigen DO - http://dx.doi.org/10.1038/mt.2011.223 ER - TY - JOUR T1 - Brief Assessment of Motor Function: Content Validity and Reliability of the Upper Extremity Gross Motor Scale AN - 1512194371; 201404704 AB - Content validity and reliability of the Brief Assessment of Motor Function (BAMF) Upper Extremity Gross Motor Scale (UEGMS) were evaluated in this prospective, descriptive study. The UEGMS is one of five BAMF ordinal scales designed for quick documentation of gross, fine, and oral motor skill levels. Designed to be independent of age and diagnosis, it is intended for use for infants through young adults. An expert panel of 17 physical therapists and 13 occupational therapists refined the content by responding to a standard questionnaire comprised of questions, which asked whether each item should be included, is clearly worded, should be reordered higher or lower, is functionally relevant, and is easily discriminated. Ratings of content validity exceeded the criterion except for two items, which may represent different perspectives of physical and occupational therapists. The UEGMS was modified using the quantitative and qualitative feedback from the questionnaires. For reliability, five raters scored videotaped motor performances of 10 children. Coefficients for inter-rater (0.94) and intra-rater (0.95) reliability were high. The results provide evidence of content validity and reliability of the UEGMS for the assessment of UEGM skill. Adapted from the source document. JF - Physical and Occupational Therapy in Pediatrics AU - Cintas, Holly Lea AU - Parks, Rebecca AU - Don, Sarah AU - Gerber, Lynn AD - Research Coordinator, Physical Therapy Section, Rehabilitation Medicine Department, Mark O. Hatfield Clinical Research Center, National Institutes of Health, Maryland, USA holly_cintas@nih.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 440 EP - 450 PB - Informa Healthcare, New York NY VL - 31 IS - 4 SN - 0194-2638, 0194-2638 KW - Evidence-based practice, knowledge translation, mobility, motor development KW - Assessment KW - Motor skills KW - Reliability KW - Motor performance KW - Occupational therapists KW - Upper limbs KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1512194371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physical+and+Occupational+Therapy+in+Pediatrics&rft.atitle=Brief+Assessment+of+Motor+Function%3A+Content+Validity+and+Reliability+of+the+Upper+Extremity+Gross+Motor+Scale&rft.au=Cintas%2C+Holly+Lea%3BParks%2C+Rebecca%3BDon%2C+Sarah%3BGerber%2C+Lynn&rft.aulast=Cintas&rft.aufirst=Holly&rft.date=2011-11-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-04-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Reliability; Occupational therapists; Assessment; Upper limbs; Motor performance; Motor skills DO - http://dx.doi.org/10.3109/01942638.2011.572148 ER - TY - JOUR T1 - The National Institutes of Health Commitment to Research on Women and Girls and AIDS AN - 1081895461; 201224055 AB - The National Institutes of Health has established the largest and most significant AIDS research program in the world through a comprehensive agenda of basic, clinical, translational, behavioral, and social sciences research on HIV infection and its associated co-infections, opportunistic infections, malignancies, and other complications. Part of a special journal issue on the subject, 'Bringing Gender Home: Implementing Gender-Responsive HIV/AIDS Programming for U.S. Women and Girls', the result of a 2-day meeting in 2010, a partnership with UNAIDS and the U.S. Office on Women's Health aimed at promoting 'increased leadership in gender-responsive programming for women and girls.'. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Brown, Anissa J AU - Bates, Angela AD - Office of AIDS Research, Office of the Director, National Institutes of Health, Bethesda, MD 20892 brownani@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - S239 EP - S240 PB - Elsevier Science, New York NY VL - 21 IS - 6s SN - 1049-3867, 1049-3867 KW - Medical research KW - Girls KW - Women KW - Health KW - Infection KW - HIV KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081895461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=The+National+Institutes+of+Health+Commitment+to+Research+on+Women+and+Girls+and+AIDS&rft.au=Brown%2C+Anissa+J%3BBates%2C+Angela&rft.aulast=Brown&rft.aufirst=Anissa&rft.date=2011-11-01&rft.volume=21&rft.issue=6s&rft.spage=S239&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2011.05.006 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - HIV; Women; Girls; Health; Medical research; Infection DO - http://dx.doi.org/10.1016/j.whi.2011.05.006 ER - TY - JOUR T1 - Decreased microRNA-214 levels in breast cancer cells coincides with increased cell proliferation, invasion and accumulation of the Polycomb Ezh2 methyltransferase AN - 1028078982; 16119965 AB - MicroRNAs (miRNAs) are small non-coding RNAs, which regulate gene expression by inhibiting translation or promoting degradation of specific target messenger RNAs (mRNAs). Alteration of the levels of a number of miRNAs is common in solid and hematological tumors. We have shown previously that miR-214 regulates Ezh2 in skeletal muscle and embryonic stem cells. The current study was aimed at examining the role of miR-214 in breast cancer where miR-214 levels are reduced but whether this phenomenon bears a functional relevance is unknown. MiR-214 expression was inversely correlated with Ezh2 mRNA and protein levels in breast cancer cell lines and at least one copy of the miR-214 alleles was found to be deleted in 24% (6/25) of primary breast tumors. Experimental increase of miR-214 in breast cancer cell lines correlated with reduction of Ezh2 protein levels, a known marker of invasion and aggressive breast cancer behavior. Supporting a direct targeting mechanism, miR-214 decreased luciferase activity from a construct containing the Ezh2 3' untranslated region. Expression of miR-214 specifically reduced cell proliferation of breast cancer cells and inhibited the invasive potential of a highly metastatic breast cancer cell line. These findings indicate that reduced miR-214 levels may contribute to breast tumorigenesis by allowing abnormally elevated Ezh2 accumulation and subsequent unchecked cell proliferation and invasion. JF - Carcinogenesis AU - Derfoul, Assia AU - Juan, Aster H AU - Difilippantonio, Michael J AU - Palanisamy, Nallasivam AU - Ried, Thomas AU - Sartorelli, Vittorio AD - 1 Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-8022, USA, sartorev@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1607 EP - 1614 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 32 IS - 11 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Translation KW - Invasiveness KW - polycomb group proteins KW - Tumorigenesis KW - miRNA KW - non-coding RNA KW - Aggressive behavior KW - mRNA KW - Gene expression KW - Metastases KW - Tumor cell lines KW - Stem cells KW - Methyltransferase KW - Embryo cells KW - Carcinogenesis KW - Breast cancer KW - Skeletal muscle KW - Cell proliferation KW - N 14830:RNA KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028078982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Decreased+microRNA-214+levels+in+breast+cancer+cells+coincides+with+increased+cell+proliferation%2C+invasion+and+accumulation+of+the+Polycomb+Ezh2+methyltransferase&rft.au=Derfoul%2C+Assia%3BJuan%2C+Aster+H%3BDifilippantonio%2C+Michael+J%3BPalanisamy%2C+Nallasivam%3BRied%2C+Thomas%3BSartorelli%2C+Vittorio&rft.aulast=Derfoul&rft.aufirst=Assia&rft.date=2011-11-01&rft.volume=32&rft.issue=11&rft.spage=1607&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgr184 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Last updated - 2013-11-15 N1 - SubjectsTermNotLitGenreText - Translation; Invasiveness; polycomb group proteins; miRNA; Tumorigenesis; non-coding RNA; Aggressive behavior; mRNA; Metastases; Gene expression; Stem cells; Tumor cell lines; Methyltransferase; Embryo cells; Carcinogenesis; Breast cancer; Skeletal muscle; Cell proliferation DO - http://dx.doi.org/10.1093/carcin/bgr184 ER - TY - JOUR T1 - In vivo detection of intermediate metabolic products of [1-13C]ethanol in the brain using 13C MRS AN - 1017970019; 16700453 AB - In this study, in vivo13C MRS was used to investigate the labeling of brain metabolites after intravenous administration of [1-13C]ethanol. After [1-13C]ethanol had been administered systemically to rats, 13C labels were detected in glutamate, glutamine and aspartate in the carboxylic and amide carbon spectral region. 13C-labeled bicarbonate HCO (161.0ppm) was also detected. Saturating acetaldehyde C1 at 207.0ppm was found to have no effect on the ethanol C1 (57.7ppm) signal intensity after extensive signal averaging, providing direct in vivo evidence that direct metabolism of alcohol by brain tissue is minimal. To compare the labeling of brain metabolites by ethanol with labeling by glucose, in vivo time course data were acquired during intravenous co-infusion of [1-13C]ethanol and [13C6]-D-glucose. In contrast with labeling by [13C6]-D-glucose, which produced doublets of carboxylic/amide carbons with a J coupling constant of 51Hz, the simultaneously detected glutamate and glutamine singlets were labeled by [1-13C]ethanol. As 13C labels originating from ethanol enter the brain after being converted into [1-13C]acetate in the liver, and the direct metabolism of ethanol by brain tissue is negligible, it is suggested that orally or intragastrically administered 13C-labeled ethanol may be used to study brain metabolism and glutamatergic neurotransmission in investigations involving alcohol administration. In vivo13C MRS of rat brain following intragastric administration of 13C-labeled ethanol is demonstrated. Published in 2011 by John Wiley & Sons, Ltd. JF - NMR in Biomedicine AU - Xiang, Yun AU - Shen, Jun Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 1054 EP - 1062 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 24 IS - 9 SN - 1099-1492, 1099-1492 KW - Biotechnology and Bioengineering Abstracts KW - Glutamine KW - Intravenous administration KW - Data processing KW - Acetaldehyde KW - Glucose KW - Brain KW - Bicarbonate KW - Metabolites KW - Glutamatergic transmission KW - Carbon KW - Neurotransmission KW - Liver KW - N.M.R. KW - Glutamic acid KW - amides KW - Ethanol KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017970019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=In+vivo+detection+of+intermediate+metabolic+products+of+%5B1-13C%5Dethanol+in+the+brain+using+13C+MRS&rft.au=Xiang%2C+Yun%3BShen%2C+Jun&rft.aulast=Xiang&rft.aufirst=Yun&rft.date=2011-11-01&rft.volume=24&rft.issue=9&rft.spage=1054&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=10991492&rft_id=info:doi/10.1002%2Fnbm.1653 L2 - http://onlinelibrary.wiley.com/doi/10.1002/nbm.1653/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Intravenous administration; Glutamine; Data processing; Acetaldehyde; Brain; Glucose; Metabolites; Bicarbonate; Glutamatergic transmission; Carbon; Neurotransmission; Liver; N.M.R.; Glutamic acid; amides; Ethanol DO - http://dx.doi.org/10.1002/nbm.1653 ER - TY - JOUR T1 - Serum thyroglobulin, a biomarker for iodine deficiency, is not associated with increased risk of upper gastrointestinal cancers in a large Chinese cohort AN - 1017965016; 16689741 AB - Iodine concentrates in gastric tissue and may act as an antioxidant for the stomach. We previously showed that self-reported goiter was associated with significantly increased risk of gastric noncardia adenocarcinoma (GNCA) and nonsignificantly increased risks of gastric cardia adenocarcinoma (GCA) and esophageal squamous cell carcinoma (ESCC) in a prospective case-cohort study in a high-risk population in China. Negatively correlated with iodine levels, serum thyroglobulin (Tg) is a more sensitive biomarker of iodine deficiency than goiter. Our study aimed to determine whether baseline serum Tg was also associated with development of GNCA, GCA and ESCC in the same cohort, the Linxian General Population Nutrition Intervention Trial. Sera from ~200 subjects of each case type and 400 noncases were tested for serum Tg concentration using appropriate assays. Tg was modeled as sex- and assay-specific quartiles in Cox regression models adjusted for age, smoking, alcohol, Helicobacter pylori status, pepsinogens I/II ratio, family history and commune of residence. In the final combined analysis, participants in the highest quartile of serum Tg, compared to those in the lowest quartile, had adjusted hazard ratios of 0.88 (95% confidence interval 0.50-1.52), 1.14 (0.63-2.05) and 0.78 (0.47-1.31) for GNCA, GCA and ESCC, respectively. Using serum Tg, a sensitive biomarker of iodine deficiency, we found no association between serum Tg concentrations and risk of these upper gastrointestinal (UGI) cancers in the study population. Our results do not support the hypothesis that iodine deficiency, as assessed by serum Tg, is associated with an increased risk of UGI cancers. JF - International Journal of Cancer AU - Lin, Shih-Wen AU - Fan, Jin-Hu AU - Dawsey, Sanford M AU - Taylor, Philip R AU - Qiao, You-Lin AU - Abnet, Christian C AD - Cancer Prevention Fellowship Program, National Cancer Institute, Bethesda, MD, lins4@mail.nih.gov Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 2284 EP - 2289 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 129 IS - 9 SN - 1097-0215, 1097-0215 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Alcohol KW - Antioxidants KW - Bioindicators KW - Cancer KW - Genetics KW - Intervention KW - Iodine KW - Nutrition KW - intervention KW - Helicobacter pylori KW - China, People's Rep. KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017965016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Serum+thyroglobulin%2C+a+biomarker+for+iodine+deficiency%2C+is+not+associated+with+increased+risk+of+upper+gastrointestinal+cancers+in+a+large+Chinese+cohort&rft.au=Lin%2C+Shih-Wen%3BFan%2C+Jin-Hu%3BDawsey%2C+Sanford+M%3BTaylor%2C+Philip+R%3BQiao%2C+You-Lin%3BAbnet%2C+Christian+C&rft.aulast=Lin&rft.aufirst=Shih-Wen&rft.date=2011-11-01&rft.volume=129&rft.issue=9&rft.spage=2284&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=10970215&rft_id=info:doi/10.1002%2Fijc.25789 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ijc.25789/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Bioindicators; Alcohol; Genetics; Age; Antioxidants; intervention; Intervention; Iodine; Nutrition; Cancer; Helicobacter pylori; China, People's Rep. DO - http://dx.doi.org/10.1002/ijc.25789 ER - TY - CPAPER T1 - Cyber bullying and victimization among US adolescents T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313017879; 6051486 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Wang, Jing AU - Iannotti, Ronald Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - victimization KW - cyberbullying KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313017879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Cyber+bullying+and+victimization+among+US+adolescents&rft.au=Wang%2C+Jing%3BIannotti%2C+Ronald&rft.aulast=Wang&rft.aufirst=Jing&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - In Search of better Strategies to Meet MDG 4 & 5 T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313013375; 6048734 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Wright, Linda Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313013375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=In+Search+of+better+Strategies+to+Meet+MDG+4+%26amp%3B+5&rft.au=Wright%2C+Linda&rft.aulast=Wright&rft.aufirst=Linda&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Using Social Media to Reach Women with The Heart Truth T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313009362; 6048508 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Taubenheim, Ann Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Heart UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313009362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Using+Social+Media+to+Reach+Women+with+The+Heart+Truth&rft.au=Taubenheim%2C+Ann&rft.aulast=Taubenheim&rft.aufirst=Ann&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Engaging communities in setting and prioritizing health communication research agenda T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313008660; 6049459 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Chou, Wen-ying AU - Keefe, Brian AU - Sanders, Amy AU - Hesse, Bradford Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Communication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313008660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=In-vivo+optical+measurement+of+direct-+and+indirect-pathway+striatal+neuron+activity+in+mice+performing+an+operant+task&rft.au=Cui%2C+G%3BJun%2C+S%3BJin%2C+X%3BVogel%2C+S%3BLovinger%2C+D%3BCosta%2C+R&rft.aulast=Cui&rft.aufirst=G&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Impact of social media in disseminating cancer information to multicultural communities T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313007238; 6048279 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Alexander, James AU - Joseph, Natalie AU - Kwon, Harry AU - Bartholomew, Jill AU - Padberg, Rose AU - Kiourkas, Iliana AU - Hale, Lena AU - Devine, Theresa AU - Greenwood, Addison AU - La Porta, Madeline Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Cancer KW - culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313007238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Impact+of+social+media+in+disseminating+cancer+information+to+multicultural+communities&rft.au=Alexander%2C+James%3BJoseph%2C+Natalie%3BKwon%2C+Harry%3BBartholomew%2C+Jill%3BPadberg%2C+Rose%3BKiourkas%2C+Iliana%3BHale%2C+Lena%3BDevine%2C+Theresa%3BGreenwood%2C+Addison%3BLa+Porta%2C+Madeline&rft.aulast=Alexander&rft.aufirst=James&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Assessing the public health impact of personalized medicine T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313006178; 6051084 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Wacholder, Sholom Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313006178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Assessing+the+public+health+impact+of+personalized+medicine&rft.au=Wacholder%2C+Sholom&rft.aulast=Wacholder&rft.aufirst=Sholom&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - On the Road to Personalized Genomic Medicine in Oncology T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313006163; 6051083 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Simon, Richard Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Oncology KW - genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313006163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=On+the+Road+to+Personalized+Genomic+Medicine+in+Oncology&rft.au=Simon%2C+Richard&rft.aulast=Simon&rft.aufirst=Richard&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Relations between child-reported food exposure and preferences, and parent-reported food availability to child dietary intake and quality T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313000101; 6050115 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Lipsky, Leah AU - Nansel, Tonja AU - Haynie, Denise AU - Mehta, Sanjeev AU - Laffel, Lori Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Ingestion KW - Diets KW - food availability KW - Food preferences KW - Dietary intake KW - Food quality KW - Food availability UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313000101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Relations+between+child-reported+food+exposure+and+preferences%2C+and+parent-reported+food+availability+to+child+dietary+intake+and+quality&rft.au=Lipsky%2C+Leah%3BNansel%2C+Tonja%3BHaynie%2C+Denise%3BMehta%2C+Sanjeev%3BLaffel%2C+Lori&rft.aulast=Lipsky&rft.aufirst=Leah&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Harmonization of Diagnostic Criteria for Hemoglobinopathies among State NBS Programs T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312995106; 6051761 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Werner, Ellen AU - Hassell, Kathryn Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Hemoglobinopathy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312995106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Harmonization+of+Diagnostic+Criteria+for+Hemoglobinopathies+among+State+NBS+Programs&rft.au=Werner%2C+Ellen%3BHassell%2C+Kathryn&rft.aulast=Werner&rft.aufirst=Ellen&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Developing standard names and codes for lysosomal storage disorders detectable by newborn screening T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312995066; 6051760 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Goodwin, Rebecca AU - Watson, Michael AU - Matern, Dietrich AU - Hill, J AU - Cuthbert, Carla AU - Abhyankar, Swapna AU - Copeland, Sara AU - Urv, Tiina AU - Sarkar, Deboshree AU - McDonald, Clement Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Storage KW - lysosomal storage diseases KW - Neonates KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312995066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Developing+standard+names+and+codes+for+lysosomal+storage+disorders+detectable+by+newborn+screening&rft.au=Goodwin%2C+Rebecca%3BWatson%2C+Michael%3BMatern%2C+Dietrich%3BHill%2C+J%3BCuthbert%2C+Carla%3BAbhyankar%2C+Swapna%3BCopeland%2C+Sara%3BUrv%2C+Tiina%3BSarkar%2C+Deboshree%3BMcDonald%2C+Clement&rft.aulast=Goodwin&rft.aufirst=Rebecca&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Primary care providers' use of risk factors and test results to determine human papillomavirus vaccine receipt T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312993389; 6051402 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Kepka, Deanna AU - Saraiya, Mona AU - Benard, Vicki AU - Berkowitz, Zahava AU - Roland, Katherine AU - Yabroff, K Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - vaccines KW - Risk factors KW - Vaccines KW - Disease control KW - Human papillomavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312993389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Primary+care+providers%27+use+of+risk+factors+and+test+results+to+determine+human+papillomavirus+vaccine+receipt&rft.au=Kepka%2C+Deanna%3BSaraiya%2C+Mona%3BBenard%2C+Vicki%3BBerkowitz%2C+Zahava%3BRoland%2C+Katherine%3BYabroff%2C+K&rft.aulast=Kepka&rft.aufirst=Deanna&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - State laws for time spent in Physical education and its relationship with adolescent weight status T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312992473; 6048319 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Oh, April AU - Hennessey, Erin AU - Perna, Frank AU - Agurs-Collins, Tanya AU - Chriqui, Jamie AU - Masse, Louise Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Adolescents KW - Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312992473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=State+laws+for+time+spent+in+Physical+education+and+its+relationship+with+adolescent+weight+status&rft.au=Oh%2C+April%3BHennessey%2C+Erin%3BPerna%2C+Frank%3BAgurs-Collins%2C+Tanya%3BChriqui%2C+Jamie%3BMasse%2C+Louise&rft.aulast=Oh&rft.aufirst=April&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Communicating risk from soil sediment contamination post-Hurricane Ike during storm recovery efforts in coastal Texas and Louisiana T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312988750; 6051481 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Sullivan, John AU - Nolen, Alexandra AU - Croisant, Sharon AU - Subra, Wilma AU - Jackson, Michael AU - Ward, Jonathan Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - USA, Louisiana KW - USA, Texas KW - Soil pollution KW - Storms KW - Sediment pollution KW - Contamination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312988750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Striosomal+and+extended+striatal+expression+of+the+CB1+cannabinoid+receptor+during+development+and+in+the+mature+mouse&rft.au=Davis%2C+M%3BLovinger%2C+D&rft.aulast=Davis&rft.aufirst=M&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Importance of comparable state and local health survey data for research to improve population health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312988071; 6050371 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Portnoy, Barry AU - Balluz, Lina Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312988071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Importance+of+comparable+state+and+local+health+survey+data+for+research+to+improve+population+health&rft.au=Portnoy%2C+Barry%3BBalluz%2C+Lina&rft.aulast=Portnoy&rft.aufirst=Barry&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A review of NIH's Office of Behavioral and Social Sciences Research (OBSSR) major activities T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312982716; 6051240 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Mabry, Patty Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - social sciences KW - Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312982716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=A+review+of+NIH%27s+Office+of+Behavioral+and+Social+Sciences+Research+%28OBSSR%29+major+activities&rft.au=Mabry%2C+Patty&rft.aulast=Mabry&rft.aufirst=Patty&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - SSA-NIH-BU collaboration to improve the disability determination process: A conceptual and operational approach based on contemporary paradigms and novel assessment methods T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312979118; 6050074 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Rasch, Elizabeth AU - Brandt, Diane AU - Chan, Leighton Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - disabilities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312979118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Two+critical+and+functionally+distinct+time+periods+for+early+face+and+body+perception&rft.au=Pitcher%2C+D%3BDuchaine%2C+B%3BWalsh%2C+V%3BKanwisher%2C+N&rft.aulast=Pitcher&rft.aufirst=D&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - ONE CIRCLE (Organizing Nurses to Engage Communities In Research and Collaborations Linking Evidence) to Address Youth Alcohol Use in a Reservation Community T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312979051; 6051614 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Brockie, Teresa AU - Adams, Kathleen AU - Goodman, Desiree AU - Kellam, Anita AU - Koratich, Chad AU - Elliott, Dolores AU - Kub, Joan AU - Fisher, Cheryl AU - Wallen, Gwenyth Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - nursing KW - alcohols KW - Medical personnel UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312979051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=ONE+CIRCLE+%28Organizing+Nurses+to+Engage+Communities+In+Research+and+Collaborations+Linking+Evidence%29+to+Address+Youth+Alcohol+Use+in+a+Reservation+Community&rft.au=Brockie%2C+Teresa%3BAdams%2C+Kathleen%3BGoodman%2C+Desiree%3BKellam%2C+Anita%3BKoratich%2C+Chad%3BElliott%2C+Dolores%3BKub%2C+Joan%3BFisher%2C+Cheryl%3BWallen%2C+Gwenyth&rft.aulast=Brockie&rft.aufirst=Teresa&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Research Priorities and Funding Opportunities and Mechanisms of NIAMS Related to Back Pain T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312976714; 6049247 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Panagis, James Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - back pain KW - Pain KW - Financing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312976714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Research+Priorities+and+Funding+Opportunities+and+Mechanisms+of+NIAMS+Related+to+Back+Pain&rft.au=Panagis%2C+James&rft.aulast=Panagis&rft.aufirst=James&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Communicating and Applying the 2010 Dietary Guidelines for Americans: Resources for Public Health Practice T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312975666; 6048982 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Shaikh, Abdul Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Diets KW - guidelines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312975666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Communicating+and+Applying+the+2010+Dietary+Guidelines+for+Americans%3A+Resources+for+Public+Health+Practice&rft.au=Shaikh%2C+Abdul&rft.aulast=Shaikh&rft.aufirst=Abdul&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Methods and Management: NIH Administrators, Risk Factor Epidemiology, and the Framingham Heart Study T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312972066; 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6050392 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Alvarado, Matilde AU - Vasquez, Esperanza AU - Balcazar, Hector AU - Brownstein, J Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Sustainability KW - Resource management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312970655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Sustainability+in+CHW+Community+Programs&rft.au=Alvarado%2C+Matilde%3BVasquez%2C+Esperanza%3BBalcazar%2C+Hector%3BBrownstein%2C+J&rft.aulast=Alvarado&rft.aufirst=Matilde&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Evidence-based case study materials to support the ANA environmental health nursing practice standard T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312969404; 6049944 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Backus, Ann AU - Hewitt, Jeanne AU - Chalupka, Stephanie Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - case studies KW - Environmental health KW - Nursing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312969404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Evidence-based+case+study+materials+to+support+the+ANA+environmental+health+nursing+practice+standard&rft.au=Backus%2C+Ann%3BHewitt%2C+Jeanne%3BChalupka%2C+Stephanie&rft.aulast=Backus&rft.aufirst=Ann&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Psychosocial Predictors of Observed Speeding Among Teenage Drivers During the First 18-Month of Licensure T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312968646; 6049831 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Simons-Morton, Bruce Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312968646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Psychosocial+Predictors+of+Observed+Speeding+Among+Teenage+Drivers+During+the+First+18-Month+of+Licensure&rft.au=Simons-Morton%2C+Bruce&rft.aulast=Aldworth&rft.aufirst=Z&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Understanding eating episodes: Predominant activities reported by US adults when eating or drinking in the American Time Use Survey T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312968541; 6050702 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Oh, April AU - Erinosho, Temitope AU - Fridlund Dunton, Genevieve AU - Nebeling, Linda Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Drinking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312968541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Understanding+eating+episodes%3A+Predominant+activities+reported+by+US+adults+when+eating+or+drinking+in+the+American+Time+Use+Survey&rft.au=Oh%2C+April%3BErinosho%2C+Temitope%3BFridlund+Dunton%2C+Genevieve%3BNebeling%2C+Linda&rft.aulast=Oh&rft.aufirst=April&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Revised criteria for DSM-V substance use disorders T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312962973; 6048874 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Grant, Bridget Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - substance use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312962973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Polyamidoamine+%28PAMAM%29+dendrimer+conjugates+of+neuroprotective+adenosine+receptor+antagonists&rft.au=Jacobson%2C+K%3BKumar%2C+T%3BDeflorian%2C+F%3BKecskes%2C+A%3BPhan%2C+K%3BGao%2C+Z%3BTosh%2C+D&rft.aulast=Jacobson&rft.aufirst=K&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Terminology of substance use disorders for DSM-V T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312962650; 6048872 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Compton, Wilson Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - substance use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312962650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Terminology+of+substance+use+disorders+for+DSM-V&rft.au=Compton%2C+Wilson&rft.aulast=Compton&rft.aufirst=Wilson&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Weight, weight perceptions and health-related quality of life among youth T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312961523; 6051716 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Farhat, Tilda AU - Iannotti, Ronald Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - quality of life KW - Perception KW - Quality of life UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312961523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Weight%2C+weight+perceptions+and+health-related+quality+of+life+among+youth&rft.au=Farhat%2C+Tilda%3BIannotti%2C+Ronald&rft.aulast=Farhat&rft.aufirst=Tilda&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Interactions between toxic environmental exposures and infectious diseases T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312958818; 6048653 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Birnbaum, Linda Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Infectious diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312958818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Interactions+between+toxic+environmental+exposures+and+infectious+diseases&rft.au=Birnbaum%2C+Linda&rft.aulast=Birnbaum&rft.aufirst=Linda&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Urban sprawl and cancer mortality in the United States T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312956891; 6048277 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Berrigan, David AU - Tatalovich, Zaria AU - Ewing, Reid AU - Pickle, Linda AU - Ballard-Barbash, Rachel Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - USA KW - Cancer KW - urban sprawl KW - Mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312956891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Urban+sprawl+and+cancer+mortality+in+the+United+States&rft.au=Berrigan%2C+David%3BTatalovich%2C+Zaria%3BEwing%2C+Reid%3BPickle%2C+Linda%3BBallard-Barbash%2C+Rachel&rft.aulast=Berrigan&rft.aufirst=David&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - NCCAM's Health Care Provider Portal: A Two-Pronged Approach to Evaluating an Online Health Education Program T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312956754; 6048492 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Stout, Shawn Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Education KW - Health care KW - Internet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312956754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=NCCAM%27s+Health+Care+Provider+Portal%3A+A+Two-Pronged+Approach+to+Evaluating+an+Online+Health+Education+Program&rft.au=Stout%2C+Shawn&rft.aulast=Stout&rft.aufirst=Shawn&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Analysis of the compassionate allowance (CAL) program: A systematic data-driven approach to identifying potential CAL conditions T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312956410; 6050077 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Ho, Pei-Shu AU - Huynh, Minh AU - Heuser, Aaron AU - Houtenville, Andew AU - Wheatcroft, Gloria AU - Chan, Leighton AU - Rasch, Elizabeth Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312956410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Analysis+of+the+compassionate+allowance+%28CAL%29+program%3A+A+systematic+data-driven+approach+to+identifying+potential+CAL+conditions&rft.au=Ho%2C+Pei-Shu%3BHuynh%2C+Minh%3BHeuser%2C+Aaron%3BHoutenville%2C+Andew%3BWheatcroft%2C+Gloria%3BChan%2C+Leighton%3BRasch%2C+Elizabeth&rft.aulast=Ho&rft.aufirst=Pei-Shu&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Building community resiliency and environmental justice through health and safety training T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312954794; 6048778 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Beard, Sharon Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Training KW - Environmental equity KW - Health and safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312954794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Building+community+resiliency+and+environmental+justice+through+health+and+safety+training&rft.au=Beard%2C+Sharon&rft.aulast=Beard&rft.aufirst=Sharon&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Use of complementary and alternative medicine during active surveillance among prostate cancer patients T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312943622; 6050577 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Al-Keliddar, Miriam AU - Mikhail, Isis Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - prostate cancer KW - Prostate cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312943622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Use+of+complementary+and+alternative+medicine+during+active+surveillance+among+prostate+cancer+patients&rft.au=Al-Keliddar%2C+Miriam%3BMikhail%2C+Isis&rft.aulast=Al-Keliddar&rft.aufirst=Miriam&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Alliance Building: Mobilizing Partners to Share the Signs and Symptoms of COPD T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312928998; 6051604 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Ndenecho, Monique Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Chronic obstructive pulmonary disease KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312928998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Alliance+Building%3A+Mobilizing+Partners+to+Share+the+Signs+and+Symptoms+of+COPD&rft.au=Ndenecho%2C+Monique&rft.aulast=Ndenecho&rft.aufirst=Monique&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Change in body size during early adulthood and prevalence of diabetes mellitus T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312919059; 6048667 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Golozar, Asieh AU - Etemadi, Arash AU - Khademi, Hooman AU - Kamangar, Farin AU - Poustchi, Hossein AU - Islami, Farhad AU - Freedman, Neal AU - Taylor, Philip AU - Pharoah, Paul AU - Boffetta, Paulo AU - Brennan, Paul AU - Abnet, Christian AU - Dawsey, Sanford AU - Malekzadeh, Reza Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - diabetes mellitus KW - body size KW - Body size KW - Diabetes mellitus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312919059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Change+in+body+size+during+early+adulthood+and+prevalence+of+diabetes+mellitus&rft.au=Golozar%2C+Asieh%3BEtemadi%2C+Arash%3BKhademi%2C+Hooman%3BKamangar%2C+Farin%3BPoustchi%2C+Hossein%3BIslami%2C+Farhad%3BFreedman%2C+Neal%3BTaylor%2C+Philip%3BPharoah%2C+Paul%3BBoffetta%2C+Paulo%3BBrennan%2C+Paul%3BAbnet%2C+Christian%3BDawsey%2C+Sanford%3BMalekzadeh%2C+Reza&rft.aulast=Golozar&rft.aufirst=Asieh&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Assessing environmental exposures: State-of-the-art approaches for dust contamination T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312907449; 6051706 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Dellarco, Michael Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Dust KW - Contamination KW - Environmental assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312907449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Assessing+environmental+exposures%3A+State-of-the-art+approaches+for+dust+contamination&rft.au=Dellarco%2C+Michael&rft.aulast=Dellarco&rft.aufirst=Michael&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Domestic and international efforts in mental health by the National Institute of Mental Health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312906977; 6051431 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Collins, Pamela Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - mental disorders KW - Mental disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312906977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Domestic+and+international+efforts+in+mental+health+by+the+National+Institute+of+Mental+Health&rft.au=Collins%2C+Pamela&rft.aulast=Collins&rft.aufirst=Pamela&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Exploring the CHW Role: From Preparation to Practice T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312903619; 6050388 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Alvarado, Matilde Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312903619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Exploring+the+CHW+Role%3A+From+Preparation+to+Practice&rft.au=Alvarado%2C+Matilde&rft.aulast=Alvarado&rft.aufirst=Matilde&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Identifying a Conceptual Approach for Assessing the Influence of Father Involvement on Maternal and Child Health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312901175; 6049051 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Hill, Carl Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312901175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Identifying+a+Conceptual+Approach+for+Assessing+the+Influence+of+Father+Involvement+on+Maternal+and+Child+Health&rft.au=Hill%2C+Carl&rft.aulast=Hill&rft.aufirst=Carl&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8+ T Cell Immunity AN - 926892067; 15966847 AB - Our goal is to develop a vaccine that sustainably prevents Plasmodium falciparum (Pf) malaria in greater than or equal to 80% of recipients. Pf sporozoites (PfSPZ) administered by mosquito bites are the only immunogens shown to induce such protection in humans. Such protection is thought to be mediated by CD8+ T cells in the liver that secrete interferon- gamma (IFN- gamma ). We report that purified irradiated PfSPZ administered to 80 volunteers by needle inoculation in the skin was safe, but suboptimally immunogenic and protective. Animal studies demonstrated that intravenous immunization was critical for inducing a high frequency of PfSPZ-specific CD8+, IFN- gamma -producing T cells in the liver (nonhuman primates, mice) and conferring protection (mice). Our results suggest that intravenous administration of this vaccine will lead to the prevention of infection with Pf malaria. JF - Science (Washington) AU - Epstein, JE AU - Tewari, K AU - Lyke, KE AU - Sim, BKL AU - Billingsley, P F AU - Laurens, M B AU - Gunasekera, A AU - Chakravarty, S AU - James, E R AU - Sedegah, M AU - Richman, A AU - Velmurugan, S AU - Reyes, S AU - Li, M AU - Tucker, K AU - Ahumada, A AU - Ruben, A J AU - Li, T AU - Stafford, R AU - Eappen, A G AU - Tamminga, C AU - Bennett, J W AU - Ockenhouse, C F AU - Murphy, J R AU - Komisar, J AU - Thomas, N AU - Loyevsky, M AU - Birkett, A AU - Plowe, C V AU - Loucq, C AU - Edelman, R AU - Richie, T L AU - Seder, R A AU - Hoffman, S L AD - U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, MD 20910, USA. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Sanaria Inc., Rockville, MD 20850, USA. Protein Potential LLC, Rockville, MD 20850, USA. Howard Hughes Medical Institute, Baltimore, MD 21201, USA. Statistics Collaborative Inc., Washington, DC 20036, USA. U.S. Military Malaria Vaccine Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. PATH Malaria Vaccine Initiative, Bethesda, MD 20814, USA. Y1 - 2011/10/28/ PY - 2011 DA - 2011 Oct 28 SP - 475 EP - 480 PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 United States VL - 334 IS - 6055 SN - 0036-8075, 0036-8075 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - gamma -Interferon KW - Parasites KW - Human diseases KW - Hepatocytes KW - Bites KW - Disease control KW - Malaria KW - Infection KW - Public health KW - Lymphocytes T KW - Aquatic insects KW - Intravenous administration KW - Skin KW - Sporozoites KW - Plasmodium falciparum KW - CD8 antigen KW - Immunity KW - Immunization KW - Immunogenicity KW - Inoculation KW - Liver KW - Vaccines KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926892067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=Live+Attenuated+Malaria+Vaccine+Designed+to+Protect+Through+Hepatic+CD8%2B+T+Cell+Immunity&rft.au=Epstein%2C+JE%3BTewari%2C+K%3BLyke%2C+KE%3BSim%2C+BKL%3BBillingsley%2C+P+F%3BLaurens%2C+M+B%3BGunasekera%2C+A%3BChakravarty%2C+S%3BJames%2C+E+R%3BSedegah%2C+M%3BRichman%2C+A%3BVelmurugan%2C+S%3BReyes%2C+S%3BLi%2C+M%3BTucker%2C+K%3BAhumada%2C+A%3BRuben%2C+A+J%3BLi%2C+T%3BStafford%2C+R%3BEappen%2C+A+G%3BTamminga%2C+C%3BBennett%2C+J+W%3BOckenhouse%2C+C+F%3BMurphy%2C+J+R%3BKomisar%2C+J%3BThomas%2C+N%3BLoyevsky%2C+M%3BBirkett%2C+A%3BPlowe%2C+C+V%3BLoucq%2C+C%3BEdelman%2C+R%3BRichie%2C+T+L%3BSeder%2C+R+A%3BHoffman%2C+S+L&rft.aulast=Epstein&rft.aufirst=JE&rft.date=2011-10-28&rft.volume=334&rft.issue=6055&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Disease control; Malaria; Immunity; Vaccines; Aquatic insects; Immunization; Public health; gamma -Interferon; Intravenous administration; Skin; Bites; Hepatocytes; Sporozoites; CD8 antigen; Infection; Immunogenicity; Lymphocytes T; Liver; Inoculation; Plasmodium falciparum ER - TY - JOUR T1 - Enhanced neurodegeneration after a high dose of methamphetamine in adenosine A3 receptor null mutant mice AN - 902370017; 15763667 AB - Previous reports have indicated that adenosine A3 receptor (A3R) knockout mice are more sensitive to ischemic or hypoxic brain injury. The purpose of this study was to examine if suppression of A3R expression is associated with increase in sensitivity to injury induced by a high dose of methamphetamine (Meth). Adult male A3R null mutant (-/-) mice and their controls (+/+) were injected with four doses (2 h apart) of Meth (10 mg/kg) or saline. Animals were placed in a behavioral activity chamber, equipped with food and water, for 52 h starting from one day after injections. The first 4 h were used for studying exploratory behaviors, and the next 48 h were used to measure locomotor activity. High doses of Meth equally reduced the 4-h exploratory behavior in -/- and +/+ mice. Meth suppressed locomotor activity between 4 and 52 h in both groups, with a greater reduction being found in the -/- mice. Brain tissues were collected at 3 days after the Meth or saline injections. Meth treatment reduced striatal dopamine (DA) levels in both +/+ and -/- mice with an increase in 3,4-dihydroxyphenylacetic acid (DOPAC)/DA ratio being found only in -/- animals. Meth also significantly increased ionized calcium-binding adaptor molecule 1 (Iba-1) and cleaved caspase-3 level in striatum, as well as Iba-1 and TNF alpha mRNA expression in nigra in -/-, compared to +/+, mice. Previous studies have shown that pharmacological suppression of vesicular monoamine transport 2 (VMAT2) by reserpine enhanced Meth toxicity by increasing cytosolic DA and inflammation. A significant reduction in striatal VMAT2 expression was found in -/- mice compared to +/+ mice, suggesting that increase in sensitivity to Meth injury in -/- mice may be related to a reduction in VMAT2 expression in these mice. In conclusion, our data suggest that A3R -/- mice are more sensitive to high doses of Meth. JF - Neuroscience AU - Shen, H AU - Luo, Y AU - Yu, S-J AU - Wang, Y Y1 - 2011/10/27/ PY - 2011 DA - 2011 Oct 27 SP - 170 EP - 180 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 194 SN - 0306-4522, 0306-4522 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Adenosine A3 receptors KW - monoamines KW - Brain injury KW - Data processing KW - Exploratory behavior KW - Injuries KW - Reserpine KW - Food KW - Ischemia KW - Toxicity KW - Gene expression KW - Methamphetamine KW - Vesicular amine transporter KW - adaptor proteins KW - Dopamine KW - Locomotor activity KW - Neostriatum KW - Caspase-3 KW - Tumor necrosis factor- alpha KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902370017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Enhanced+neurodegeneration+after+a+high+dose+of+methamphetamine+in+adenosine+A3+receptor+null+mutant+mice&rft.au=Shen%2C+H%3BLuo%2C+Y%3BYu%2C+S-J%3BWang%2C+Y&rft.aulast=Shen&rft.aufirst=H&rft.date=2011-10-27&rft.volume=194&rft.issue=&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/10.1016%2Fj.neuroscience.2011.08.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-06-14 N1 - SubjectsTermNotLitGenreText - monoamines; Adenosine A3 receptors; Data processing; Brain injury; Reserpine; Injuries; Exploratory behavior; Food; Toxicity; Ischemia; Gene expression; adaptor proteins; Vesicular amine transporter; Methamphetamine; Dopamine; Locomotor activity; Neostriatum; Caspase-3; Tumor necrosis factor- alpha DO - http://dx.doi.org/10.1016/j.neuroscience.2011.08.013 ER - TY - JOUR T1 - Physical activity and breast cancer risk in Chinese women AN - 1008826759; 16451058 AB - Background: The influence of different types and intensities of physical activity on risk for breast cancer is unclear. Methods: In a prospective cohort of 73 049 Chinese women (40-70 years), who had worked outside the home, we studied breast cancer risk in relation to specific types of self-reported and work history-related physical activity, including adolescent and adult exercise and household activity and walking and cycling for transportation. Occupational sitting time and physical activity energy expenditure were assigned based on lifetime occupational histories. Results: In all, 717 incident breast cancer cases were diagnosed. Breast cancer risk was lower for women in the lowest quartile of average occupational sitting time and in the highest quartile of average occupational energy expenditure (adjusted hazard ratio (HR): 0.81 and 0.73, respectively, P less than or equal to 0.05). Adult exercise at or above the recommended level (8 metabolic equivalent (MET) h per week per year) was associated with lower risk (adjusted HR: 0.73, P<0.05) in post-menopausal women. Analysis of joint effects showed that having both an active job and exercise participation did not confer an additional benefit. Other common daily activities were not associated with lower risk.Interpretation:These findings suggest that both exercise and occupational activity are associated with lower breast cancer risk, which supports current health promotion campaigns promoting exercise. JF - British Journal of Cancer AU - Pronk, A AU - Ji, B-T AU - Shu, X-O AU - Chow, W-H AU - Xue, S AU - Yang, G AU - Li, H-L AU - Rothman, N AU - Gao, Y-T AU - Zheng, W AU - Matthews, C E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8100, MSC 7240, Bethesda, MD 20892, USA Y1 - 2011/10/25/ PY - 2011 DA - 2011 Oct 25 SP - 1443 EP - 1450 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 105 IS - 9 SN - 0007-0920, 0007-0920 KW - Physical Education Index; Health & Safety Science Abstracts; Risk Abstracts KW - Historical account KW - Home KW - Physical activity KW - Adolescence KW - Women KW - Breasts KW - Exercise KW - Adults KW - Cancer KW - Energy cost KW - households KW - Transportation KW - Households KW - Breast cancer KW - Females KW - health promotion KW - Sitting KW - physical activity KW - Adolescents KW - Health promotion KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1008826759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Physical+activity+and+breast+cancer+risk+in+Chinese+women&rft.au=Pronk%2C+A%3BJi%2C+B-T%3BShu%2C+X-O%3BChow%2C+W-H%3BXue%2C+S%3BYang%2C+G%3BLi%2C+H-L%3BRothman%2C+N%3BGao%2C+Y-T%3BZheng%2C+W%3BMatthews%2C+C+E&rft.aulast=Pronk&rft.aufirst=A&rft.date=2011-10-25&rft.volume=105&rft.issue=9&rft.spage=1443&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fbjc.2011.370 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2013-11-15 N1 - SubjectsTermNotLitGenreText - Energy cost; Home; Adolescence; Women; Breasts; Sitting; Adults; Exercise; Cancer; Historical account; households; Transportation; Households; Physical activity; Breast cancer; health promotion; Females; physical activity; Adolescents; Health promotion DO - http://dx.doi.org/10.1038/bjc.2011.370 ER - TY - JOUR T1 - XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes. AN - 900642120; 21967769 AB - Activation-induced deaminase (AID) deaminates cytosine to uracil in immunoglobulin genes. Uracils in DNA can be recognized by uracil DNA glycosylase and abasic endonuclease to produce single-strand breaks. The breaks are repaired either faithfully by DNA base excision repair (BER) or mutagenically to produce somatic hypermutation (SHM) and class switch recombination (CSR). To unravel the interplay between repair and mutagenesis, we decreased the level of x-ray cross-complementing 1 (XRCC1), a scaffold protein involved in BER. Mice heterozygous for XRCC1 showed a significant increase in the frequencies of SHM in Igh variable regions in Peyer's patch cells, and of double-strand breaks in the switch regions during CSR. Although the frequency of CSR was normal in Xrcc1(+/-) splenic B cells, the length of microhomology at the switch junctions decreased, suggesting that XRCC1 also participates in alternative nonhomologous end joining. Furthermore, Xrcc1(+/-) B cells had reduced Igh/c-myc translocations during CSR, supporting a role for XRCC1 in microhomology-mediated joining. Our results imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways. JF - The Journal of experimental medicine AU - Saribasak, Huseyin AU - Maul, Robert W AU - Cao, Zheng AU - McClure, Rhonda L AU - Yang, William AU - McNeill, Daniel R AU - Wilson, David M AU - Gearhart, Patricia J AD - Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.. Y1 - 2011/10/24/ PY - 2011 DA - 2011 Oct 24 SP - 2209 EP - 2216 VL - 208 IS - 11 KW - DNA-Binding Proteins KW - 0 KW - X-ray repair cross complementing protein 1 KW - Uracil-DNA Glycosidase KW - EC 3.2.2.- KW - AICDA (activation-induced cytidine deaminase) KW - EC 3.5.4.- KW - Cytidine Deaminase KW - EC 3.5.4.5 KW - Index Medicus KW - Cytidine Deaminase -- metabolism KW - Animals KW - DNA Repair KW - Uracil-DNA Glycosidase -- metabolism KW - Immunoglobulin Class Switching KW - Mice KW - DNA Breaks, Double-Stranded KW - Immunoglobulin Switch Region KW - Recombination, Genetic KW - Uracil-DNA Glycosidase -- genetics KW - Mice, Inbred C57BL KW - Cytidine Deaminase -- genetics KW - B-Lymphocytes -- physiology KW - Somatic Hypermutation, Immunoglobulin KW - Genes, Immunoglobulin KW - DNA-Binding Proteins -- genetics KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900642120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+experimental+medicine&rft.atitle=XRCC1+suppresses+somatic+hypermutation+and+promotes+alternative+nonhomologous+end+joining+in+Igh+genes.&rft.au=Saribasak%2C+Huseyin%3BMaul%2C+Robert+W%3BCao%2C+Zheng%3BMcClure%2C+Rhonda+L%3BYang%2C+William%3BMcNeill%2C+Daniel+R%3BWilson%2C+David+M%3BGearhart%2C+Patricia+J&rft.aulast=Saribasak&rft.aufirst=Huseyin&rft.date=2011-10-24&rft.volume=208&rft.issue=11&rft.spage=2209&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+experimental+medicine&rft.issn=1540-9538&rft_id=info:doi/10.1084%2Fjem.20111135 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-03 N1 - Date created - 2011-10-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 2001 Mar 15;29(6):E33 [11239010] Nucleic Acids Res. 2011 Oct;39(18):7992-8004 [21737425] Curr Biol. 2002 Oct 15;12(20):1748-55 [12401169] DNA Repair (Amst). 2003 Sep 18;2(9):955-69 [12967653] Cell. 2004 Aug 20;118(4):431-8 [15315756] Mol Cell. 2004 Oct 22;16(2):163-71 [15494304] Eur J Immunol. 1994 Nov;24(11):2918-21 [7957583] Dev Biol. 1999 Apr 15;208(2):513-29 [10191063] J Biol Chem. 2004 Dec 31;279(53):55117-26 [15498778] J Exp Med. 2005 Jan 17;201(2):189-94 [15657289] Cancer Res. 2005 May 15;65(10):4020-30 [15899791] Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8656-61 [15939880] J Immunol. 2006 Jan 1;176(1):365-71 [16365429] EMBO J. 2006 Feb 8;25(3):585-95 [16407970] Mol Cell Biol. 2006 May;26(10):3935-41 [16648486] DNA Repair (Amst). 2007 Feb 4;6(2):244-53 [17127106] Science. 2007 Jan 19;315(5810):377-81 [17170253] DNA Repair (Amst). 2007 Apr 1;6(4):544-59 [17112792] J Exp Med. 2007 Jul 9;204(7):1677-89 [17591858] J Exp Med. 2007 Jul 9;204(7):1717-27 [17606631] Nature. 2007 Sep 27;449(7161):478-82 [17713479] J Exp Med. 2007 Nov 26;204(12):3017-26 [18025127] Mol Cell. 2008 Feb 29;29(4):477-87 [18313385] J Exp Med. 2009 May 11;206(5):1047-56 [19364882] J Exp Med. 2009 Jun 8;206(6):1237-44 [19433618] J Exp Med. 2009 Aug 3;206(8):1817-30 [19596805] Nat Struct Mol Biol. 2009 Aug;16(8):808-13 [19633670] Cell Cycle. 2009 Oct 1;8(19):3097-101 [19738437] J Exp Med. 2010 Feb 15;207(2):417-27 [20142431] Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3034-9 [20133803] Nat Struct Mol Biol. 2010 Apr;17(4):410-6 [20208544] Adv Immunol. 2010;105:159-91 [20510733] PLoS One. 2010;5(6):e11182 [20567595] Nat Immunol. 2011 Jan;12(1):70-6 [21151102] Nat Struct Mol Biol. 2011 Jan;18(1):75-9 [21131982] Nature. 2002 Sep 5;419(6902):43-8 [12214226] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1084/jem.20111135 ER - TY - JOUR T1 - Predictive models for cytochrome p450 isozymes based on quantitative high throughput screening data. AN - 900635697; 21905670 AB - The human cytochrome P450 (CYP450) isozymes are the most important enzymes in the body to metabolize many endogenous and exogenous substances including environmental toxins and therapeutic drugs. Any unnecessary interactions between a small molecule and CYP450 isozymes may raise a potential to disarm the integrity of the protection. Accurately predicting the potential interactions between a small molecule and CYP450 isozymes is highly desirable for assessing the metabolic stability and toxicity of the molecule. The National Institutes of Health Chemical Genomics Center (NCGC) has screened a collection of over 17,000 compounds against the five major isozymes of CYP450 (1A2, 2C9, 2C19, 2D6, and 3A4) in a quantitative high throughput screening (qHTS) format. In this study, we developed support vector classification (SVC) models for these five isozymes using a set of customized generic atom types. The CYP450 data sets were randomly split into equal-sized training and test sets. The optimized SVC models exhibited high predictive power against the test sets for all five CYP450 isozymes with accuracies of 0.93, 0.89, 0.89, 0.85, and 0.87 for 1A2, 2C9, 2C19, 2D6, and 3A4, respectively, as measured by the area under the receiver operating characteristic (ROC) curves. The important atom types and features extracted from the five models are consistent with the structural preferences for different CYP450 substrates reported in the literature. We also identified novel features with significant discerning power to separate CYP450 actives from inactives. These models can be useful in prioritizing compounds in a drug discovery pipeline or recognizing the toxic potential of environmental chemicals. JF - Journal of chemical information and modeling AU - Sun, Hongmao AU - Veith, Henrike AU - Xia, Menghang AU - Austin, Christopher P AU - Huang, Ruili AD - National Institutes of Health, Chemical Genomics Center, NIH, Bethesda, Maryland 20892, United States. Y1 - 2011/10/24/ PY - 2011 DA - 2011 Oct 24 SP - 2474 EP - 2481 VL - 51 IS - 10 KW - Isoenzymes KW - 0 KW - Small Molecule Libraries KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - ROC Curve KW - Small Molecule Libraries -- metabolism KW - Humans KW - Protein Binding KW - Small Molecule Libraries -- chemistry KW - Isoenzymes -- metabolism KW - Support Vector Machine KW - High-Throughput Screening Assays -- methods KW - Cytochrome P-450 Enzyme System -- metabolism KW - Drug Evaluation, Preclinical -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900635697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chemical+information+and+modeling&rft.atitle=Predictive+models+for+cytochrome+p450+isozymes+based+on+quantitative+high+throughput+screening+data.&rft.au=Sun%2C+Hongmao%3BVeith%2C+Henrike%3BXia%2C+Menghang%3BAustin%2C+Christopher+P%3BHuang%2C+Ruili&rft.aulast=Sun&rft.aufirst=Hongmao&rft.date=2011-10-24&rft.volume=51&rft.issue=10&rft.spage=2474&rft.isbn=&rft.btitle=&rft.title=Journal+of+chemical+information+and+modeling&rft.issn=1549-960X&rft_id=info:doi/10.1021%2Fci200311w LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-02-14 N1 - Date created - 2011-10-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Top Med Chem. 2006;6(15):1609-18 [16918472] Curr Top Med Chem. 2006;6(15):1579-91 [16918470] Nat Biotechnol. 2006 Dec;24(12):1565-7 [17160063] J Biol Chem. 2007 May 11;282(19):14348-55 [17311915] J Mol Graph Model. 2008 Jun;26(8):1315-26 [18328754] Curr Med Chem. 2009;16(2):232-44 [19149574] Xenobiotica. 2009 Aug;39(8):625-35 [19514836] Curr Med Chem. 2009;16(24):3093-121 [19689286] Expert Opin Drug Metab Toxicol. 2009 Oct;5(10):1245-66 [19708826] Nat Biotechnol. 2009 Nov;27(11):1050-5 [19855396] Antioxid Redox Signal. 2010 Oct;13(8):1273-96 [20446763] J Med Chem. 2011 Mar 24;54(6):1539-54 [21344906] Future Med Chem. 2010 Sep;2(9):1451-68 [21103389] Br J Clin Pharmacol. 1999 Nov;48(5):716-27 [10594474] BMJ. 2000 Apr 8;320(7240):987-90 [10753155] Nature. 2003 Jul 24;424(6947):464-8 [12861225] J Chem Inf Comput Sci. 2004 Mar-Apr;44(2):748-57 [15032557] J Chem Inf Comput Sci. 2004 May-Jun;44(3):993-9 [15154767] Science. 2004 Jul 30;305(5684):683-6 [15256616] Clin Invest Med. 1989 Dec;12(6):357-62 [2612087] Biochemistry. 1994 May 31;33(21):6450-5 [8204577] Science. 1999 Oct 15;286(5439):487-91 [10521338] J Biomol Screen. 2005 Apr;10(3):197-205 [15809315] J Biol Chem. 2006 Mar 17;281(11):7614-22 [16352597] Expert Opin Drug Metab Toxicol. 2006 Aug;2(4):629-45 [16859410] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13682-7 [16954191] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ci200311w ER - TY - JOUR T1 - Concurrent vs sequential adjuvant chemotherapy and hormone therapy in breast cancer: a multicenter randomized phase III trial. AN - 900624951; 21921285 AB - The most appropriate timing of chemotherapy and hormone therapy administration is a critical issue in early breast cancer patients. The purpose of our study was to compare the efficacy of concurrent vs sequential administration of adjuvant chemotherapy and tamoxifen. Women with node-positive primary breast cancer were randomly assigned to receive tamoxifen (20 mg/d for 5 years) during (concurrent arm) or after (sequential arm) adjuvant chemotherapy. Chemotherapy consisted of alternating regimens of cyclophosphamide, epidoxorubicin, and 5-fluorouracil and cyclophosphamide, methotrexate, and 5-fluorouracil every 21 days for a total of 12 cycles. The primary endpoint was overall survival (OS), and secondary endpoints were toxic effects and disease-free survival (DFS). No provision for interim analyses was made in the original study protocol. Survival curves were estimated by the Kaplan-Meier method. Multivariable Cox regression models, adjusted for age, menopausal status, tumor stage, and lymph node and hormone receptor status, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). All statistical tests were two-sided. From 1985 to 1992, 431 patients were randomly assigned and studied according to the intention-to-treat principle. After a maximum of 15.4 years of follow-up (median 12.3 years), the estimated actuarial 10-year OS was equivalent for the two study arms (concurrent arm: 111 patients, 66%, 95% CI = 59% to 72%; sequential arm: 114 patients, 65%, 95% CI = 59% to 72%, P = .86). No differences in DFS and toxic effects were evident. Four interim analyses were performed, but no alpha error adjustment was necessary because of the largely negative results of this final analysis (sequential vs concurrent arm: HR of death = 1.06, 95% CI = 0.78 to 1.44, P = .76; HR of relapse = 1.16, 95% CI = 0.88 to 1.52, P = .36). No statistically significant differences in OS, DFS, and toxic effects between concurrent and sequential adjuvant chemo- and hormone therapies were observed. Our study does not support the superiority of one schedule of chemo- and hormone-therapy administration over the other. However, because of the limited statistical power of the study, these results must be considered with caution. JF - Journal of the National Cancer Institute AU - Bedognetti, Davide AU - Sertoli, Mario Roberto AU - Pronzato, Paolo AU - Del Mastro, Lucia AU - Venturini, Marco AU - Taveggia, Paola AU - Zanardi, Elisa AU - Siffredi, Guido AU - Pastorino, Simona AU - Queirolo, Paola AU - Gardin, Giovanni AU - Wang, Ena AU - Monzeglio, Clara AU - Boccardo, Francesco AU - Bruzzi, Paolo AD - Infectious Disease and Immunogenetics Section (IDIS), Department of Transfusion Medicine, Clinical Center, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. bedodav@yahoo.it Y1 - 2011/10/19/ PY - 2011 DA - 2011 Oct 19 SP - 1529 EP - 1539 VL - 103 IS - 20 KW - Antineoplastic Agents, Hormonal KW - 0 KW - Glucuronates KW - Receptors, Estrogen KW - Receptors, Progesterone KW - epidoxorubicin glucuronide KW - Tamoxifen KW - 094ZI81Y45 KW - Epirubicin KW - 3Z8479ZZ5X KW - Cyclophosphamide KW - 8N3DW7272P KW - Fluorouracil KW - U3P01618RT KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Disease-Free Survival KW - Humans KW - Mastectomy, Segmental KW - Neoplasms, Hormone-Dependent -- drug therapy KW - Tamoxifen -- administration & dosage KW - Italy KW - Multivariate Analysis KW - Fluorouracil -- administration & dosage KW - Receptors, Progesterone -- metabolism KW - Axilla KW - Adult KW - Treatment Outcome KW - Epirubicin -- analogs & derivatives KW - Epirubicin -- administration & dosage KW - Chemotherapy, Adjuvant KW - Drug Administration Schedule KW - Neoplasm Staging KW - Glucuronates -- administration & dosage KW - Prognosis KW - Receptors, Estrogen -- metabolism KW - Kaplan-Meier Estimate KW - Risk Factors KW - Confounding Factors (Epidemiology) KW - Follow-Up Studies KW - Middle Aged KW - Lymph Node Excision KW - Methotrexate -- administration & dosage KW - Female KW - Proportional Hazards Models KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - Antineoplastic Agents, Hormonal -- administration & dosage KW - Breast Neoplasms -- metabolism KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Breast Neoplasms -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900624951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Concurrent+vs+sequential+adjuvant+chemotherapy+and+hormone+therapy+in+breast+cancer%3A+a+multicenter+randomized+phase+III+trial.&rft.au=Bedognetti%2C+Davide%3BSertoli%2C+Mario+Roberto%3BPronzato%2C+Paolo%3BDel+Mastro%2C+Lucia%3BVenturini%2C+Marco%3BTaveggia%2C+Paola%3BZanardi%2C+Elisa%3BSiffredi%2C+Guido%3BPastorino%2C+Simona%3BQueirolo%2C+Paola%3BGardin%2C+Giovanni%3BWang%2C+Ena%3BMonzeglio%2C+Clara%3BBoccardo%2C+Francesco%3BBruzzi%2C+Paolo&rft.aulast=Bedognetti&rft.aufirst=Davide&rft.date=2011-10-19&rft.volume=103&rft.issue=20&rft.spage=1529&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/10.1093%2Fjnci%2Fdjr351 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-07 N1 - Date created - 2011-10-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Oncol. 2008 Feb;19(2):299-307 [17947224] Cancer Chemother Pharmacol. 2007 Mar;59(4):515-25 [16900372] J Natl Cancer Inst. 2010 Jan 6;102(1):14-25 [20007921] Lancet. 2009 Dec 19;374(9707):2055-63 [20004966] N Engl J Med. 2010 Jun 3;362(22):2053-65 [20519679] Breast Cancer. 2010 Oct;17(4):247-53 [19728030] N Engl J Med. 2010 Dec 2;363(23):2200-10 [21121833] Ann Oncol. 2002 Feb;13(2):273-9 [11886005] Ann Oncol. 2004 Jan;15(1):79-87 [14679124] Cancer Chemother Rep. 1966 Mar;50(3):163-70 [5910392] Cancer. 1981 Jan 1;47(1):207-14 [7459811] Breast Cancer Res Treat. 1981;1(2):121-3 [7348568] Cancer Res. 1983 Nov;43(11):5298-303 [6616464] J Clin Oncol. 1985 Dec;3(12):1672-7 [4067614] J Steroid Biochem. 1985 Dec;23(6B):1097-103 [3841574] N Engl J Med. 1988 Dec 29;319(26):1681-92 [3205265] J Clin Oncol. 1989 Jun;7(6):710-7 [2715802] J Clin Oncol. 1990 Jun;8(6):1005-18 [2189950] J Clin Oncol. 1991 Feb;9(2):286-94 [1988575] Cancer Res. 1994 Jan 15;54(2):441-7 [7903910] BMJ. 1995 Sep 16;311(7007):734-7 [7549691] J Clin Oncol. 1995 Nov;13(11):2712-21 [7595729] J Clin Oncol. 1996 Oct;14(10):2731-7 [8874334] Lancet. 1998 May 16;351(9114):1451-67 [9605801] Lancet. 2005 Apr 9-15;365(9467):1308 [15823379] Lancet. 2005 May 14-20;365(9472):1687-717 [15894097] Ann Oncol. 2005 Oct;16(10):1569-83 [16148022] J Natl Cancer Inst. 2005 Dec 7;97(23):1724-33 [16333028] Ann Oncol. 2006 Jan;17(1):65-73 [16361531] Ann Oncol. 2006 Oct;17(10):1475-7 [17005630] Cancer. 2008 Feb 1;112(3 Suppl):718-22 [18072257] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jnci/djr351 ER - TY - JOUR T1 - Surface-engineered magnetic nanoparticle platforms for cancer imaging and therapy. AN - 899142007; 21548618 AB - Enormous efforts have been made toward the translation of nanotechnology into medical practice, including cancer management. Generally the applications have fallen into two categories: diagnosis and therapy. Because the targets are often the same, the development of separate approaches can miss opportunities to improve efficiency and effectiveness. The unique physical properties of nanomaterials enable them to serve as the basis for superior imaging probes to locate and report cancerous lesions and as vehicles to deliver therapeutics preferentially to those lesions. These technologies for probes and vehicles have converged in the current efforts to develop nanotheranostics, nanoplatforms with both imaging and therapeutic functionalities. These new multimodal platforms are highly versatile and valuable components of the emerging trend toward personalized medicine, which emphasizes tailoring treatments to the biology of individual patients to optimize outcomes. The close coupling of imaging and treatment within a theranostic agent and the data about the evolving course of an illness that these agents provide can facilitate informed decisions about modifications to treatment. Magnetic nanoparticles, especially superparamagnetic iron oxide nanoparticles (IONPs), have long been studied as contrast agents for magnetic resonance imaging (MRI). Owing to recent progress in synthesis and surface modification, many new avenues have opened for this class of biomaterials. Such nanoparticles are not merely tiny magnetic crystals, but potential platforms with large surface-to-volume ratios. By taking advantage of the well-developed surface chemistry of these materials, researchers can load a wide range of functionalities, such as targeting, imaging and therapeutic features, onto their surfaces. This versatility makes magnetic nanoparticles excellent scaffolds for the construction of theranostic agents, and many efforts have been launched toward this goal. In this Account, we introduce the surface engineering techniques that we and others have developed, with an emphasis on how these techniques affect the role of nanoparticles as imaging or therapeutic agents. We and others have developed a set of chemical methods to prepare magnetic nanoparticles that possess accurate sizes, shapes, compositions, magnetizations, relaxivities, and surface charges. These features, in turn, can be harnessed to adjust the toxicity and stability of the nanoparticles and, further, to load functionalities, via various mechanisms, onto the nanoparticle surfaces. JF - Accounts of chemical research AU - Xie, Jin AU - Liu, Gang AU - Eden, Henry S AU - Ai, Hua AU - Chen, Xiaoyuan AD - National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892, USA. Y1 - 2011/10/18/ PY - 2011 DA - 2011 Oct 18 SP - 883 EP - 892 VL - 44 IS - 10 KW - Index Medicus KW - Animals KW - Humans KW - Surface Properties KW - Neoplasms -- diagnosis KW - Magnetic Phenomena KW - Nanoparticles -- therapeutic use KW - Molecular Imaging -- methods KW - Neoplasms -- therapy KW - Neoplasms -- metabolism KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899142007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Accounts+of+chemical+research&rft.atitle=Surface-engineered+magnetic+nanoparticle+platforms+for+cancer+imaging+and+therapy.&rft.au=Xie%2C+Jin%3BLiu%2C+Gang%3BEden%2C+Henry+S%3BAi%2C+Hua%3BChen%2C+Xiaoyuan&rft.aulast=Xie&rft.aufirst=Jin&rft.date=2011-10-18&rft.volume=44&rft.issue=10&rft.spage=883&rft.isbn=&rft.btitle=&rft.title=Accounts+of+chemical+research&rft.issn=1520-4898&rft_id=info:doi/10.1021%2Far200044b LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-31 N1 - Date created - 2011-10-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nano Lett. 2006 Apr;6(4):669-76 [16608262] Adv Drug Deliv Rev. 2011 Aug 14;63(9):772-88 [21554908] J Nucl Med. 2007 Jul;48(7):1162-71 [17574975] Angew Chem Int Ed Engl. 2007;46(28):5397-401 [17357103] J Magn Reson Imaging. 2007 Dec;26(6):1634-41 [17968941] Nat Protoc. 2008;3(1):89-96 [18193025] Acc Chem Res. 2008 Feb;41(2):179-89 [18281944] Nanomedicine (Lond). 2008 Apr;3(2):137-40 [18373419] Eur J Nucl Med Mol Imaging. 2008 Jun;35(6):1100-8 [18204838] J Am Chem Soc. 2008 Jun 18;130(24):7542-3 [18500805] J Nucl Med. 2008 Aug;49(8):1371-9 [18632815] Exp Biol Med (Maywood). 2009 Feb;234(2):123-31 [19064945] Biomaterials. 2009 May;30(15):2919-28 [19230966] Curr Med Chem. 2009;16(10):1278-94 [19355885] J Nanosci Nanotechnol. 2009 Jan;9(1):378-85 [19441322] Acc Chem Res. 2009 Aug 18;42(8):1097-107 [19476332] Angew Chem Int Ed Engl. 2009;48(41):7668-72 [19760685] Biomaterials. 2009 Dec;30(36):6912-9 [19773081] Chem Commun (Camb). 2010 Jan 21;46(3):433-5 [20066316] Biomaterials. 2010 Apr;31(11):3016-22 [20092887] J Nanosci Nanotechnol. 2010 Jan;10(1):540-8 [20352889] Contrast Media Mol Imaging. 2010 Mar-Apr;5(2):53-8 [20235146] Chem Rev. 2010 May 12;110(5):3087-111 [20225899] ACS Nano. 2010 Aug 24;4(8):4587-94 [20731441] Chem Commun (Camb). 2010 Sep 28;46(36):6684-6 [20730157] Adv Drug Deliv Rev. 2010 Aug 30;62(11):1064-79 [20691229] Biomaterials. 2011 Jan;32(2):528-37 [20869767] Mol Pharm. 2010 Dec 6;7(6):1899-912 [20822168] ACS Nano. 2010 Dec 28;4(12):7151-60 [21043459] J Nucl Med. 2011 Jan;52(1):140-6 [21149494] Nanoscale. 2011 Jan;3(1):142-53 [20938522] Mol Imaging Biol. 2011 Feb;13(1):87-93 [20440566] Mol Imaging. 2011 Feb;10(1):3-16 [21303611] Nano Lett. 2011 Feb 9;11(2):814-9 [21210706] Mol Biosyst. 2011 Apr;7(4):993-1003 [21308113] Mol Imaging. 2009 Mar-Apr;8(2):87-100 [19397854] J Mater Sci Mater Med. 2011 Mar;22(3):601-6 [21279674] Nano Lett. 2010 Nov 10;10(11):4607-13 [20939602] J Control Release. 2011 May 30;152(1):76-83 [21277920] Mol Imaging Biol. 2011 Aug;13(4):695-701 [20717735] Nat Med. 2007 Mar;13(3):372-7 [17322898] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ar200044b ER - TY - JOUR T1 - Polymeric lipid assemblies as novel theranostic tools. AN - 899133632; 21919465 AB - Polymerizable lipids have been used in research and medical applications such as membrane models, imaging platforms, drug delivery systems, vaccine carriers, biosensors, and coating materials. The polymerization of these lipid molecules forms a covalent bond between lipid moieties, which improves the noncovalent interactions that maintain the lipid lamellar phase architecture and increases the stability of the polymerized system. Because such lipid molecules form nanoassemblies with modifiable structures that acquire the stability of polymers following covalent bond formation, these lipids are of considerable interest in the emerging field of theranostics. In this Account, we summarize the biomedical applications of polymerizable lipids (primarily phospholipids) in the context of various nanoplatforms. We discuss stable nanoplatforms, which have been used in a variety of theranostics applications. In addition, we describe methods for assembling triggerable theranostics by combining appropriate nonpolymerizable lipids with polymerizable lipids. Polymeric lipids hold promise as nanotools in the field of medical imaging, targeting, and on-demand drug delivery. Because of their similarity to biological lipids, long-term toxicity issues from polymerizable lipid nanoplatforms are predicted to be minimal. Although the field of polymeric nanocapsules is still in development, intensive efforts are underway to produce systems which could be applied to disease diagnosis and treatment. We envision that nanoimaging platforms coupled with localized drug delivery technology will have a significant impact on cancer therapy and other related diseases. The existing wealth of clinical knowledge both in the photochemistry of imaging agents and/or drugs and modifications of these agents using light will prove valuable in the further development of polymeric theranostic lipid-based nanoparticles. JF - Accounts of chemical research AU - Puri, Anu AU - Blumenthal, Robert AD - CCR Nanobiology Program, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. Y1 - 2011/10/18/ PY - 2011 DA - 2011 Oct 18 SP - 1071 EP - 1079 VL - 44 IS - 10 KW - Drug Carriers KW - 0 KW - Lipids KW - Polymers KW - Index Medicus KW - Nanostructures -- therapeutic use KW - Drug Carriers -- therapeutic use KW - Animals KW - Polymerization KW - Nanostructures -- chemistry KW - Humans KW - Drug Carriers -- chemistry KW - Polymers -- therapeutic use KW - Lipids -- chemistry KW - Nanomedicine -- methods KW - Polymers -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899133632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Accounts+of+chemical+research&rft.atitle=Polymeric+lipid+assemblies+as+novel+theranostic+tools.&rft.au=Puri%2C+Anu%3BBlumenthal%2C+Robert&rft.aulast=Puri&rft.aufirst=Anu&rft.date=2011-10-18&rft.volume=44&rft.issue=10&rft.spage=1071&rft.isbn=&rft.btitle=&rft.title=Accounts+of+chemical+research&rft.issn=1520-4898&rft_id=info:doi/10.1021%2Far2001843 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-31 N1 - Date created - 2011-10-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: FEBS Lett. 2000 Feb 4;467(1):52-6 [10664455] J Liposome Res. 2011 Jun;21(2):141-50 [20560742] Chem Phys Lipids. 2001 Aug;112(2):99-108 [11551534] Adv Drug Deliv Rev. 2001 Dec 31;53(3):273-84 [11744172] J Control Release. 2002 May 17;81(1-2):7-23 [11992674] J Magn Reson Imaging. 2002 Oct;16(4):388-93 [12353254] Chem Phys Lipids. 2003 Jan;122(1-2):191-203 [12598052] Annu Rev Biophys Biomol Struct. 2004;33:269-95 [15139814] Phys Rev Lett. 2004 Sep 3;93(10):108105 [15447457] Science. 1972 Feb 18;175(4023):720-31 [4333397] Biochim Biophys Acta. 1980 Oct 16;602(1):57-69 [6893417] Biochem Biophys Res Commun. 1981 Jul 16;101(1):131-6 [7283995] Biochim Biophys Acta. 1982 May 7;687(2):165-9 [7093246] Biochim Biophys Acta. 1983 Jan 19;727(2):327-35 [6838876] Virology. 1983 Jun;127(2):361-73 [6868370] Exp Cell Res. 1983 Jul;146(2):422-7 [6873198] Biochim Biophys Acta. 1987 May 19;924(2):341-51 [3567222] J Pharm Sci. 1987 Jan;76(1):1-5 [3585714] Biochim Biophys Acta. 1987 Jun 12;900(1):1-9 [3593706] J Lipid Res. 1990 Aug;31(8):1522-5 [2280193] Adv Colloid Interface Sci. 1991 Jan;34:31-72 [2012684] Biochemistry. 1992 Jan 28;31(3):685-94 [1731924] Chem Phys Lipids. 1991 Oct;59(3):215-24 [1804565] J Med Chem. 1992 Nov 13;35(23):4501-2 [1447751] Science. 1993 Jul 30;261(5121):585-8 [8342021] Am J Respir Crit Care Med. 1995 Oct;152(4 Pt 2):S13-5 [7551405] Chem Biol. 1996 Feb;3(2):113-20 [8807836] Nature. 1997 Jun 5;387(6633):569-72 [9177342] Biosens Bioelectron. 2007 Feb 15;22(7):1205-17 [16934970] Biotechnol Lett. 2007 Nov;29(11):1637-44 [17636387] Bioorg Med Chem Lett. 2008 Jan 15;18(2):700-3 [18086524] Acc Chem Res. 2009 Aug 18;42(8):1016-25 [19453103] FEBS Lett. 2010 May 3;584(9):1653-8 [20036662] Annu Rev Biophys. 2010;39:207-26 [20192775] Biochim Biophys Acta. 2010 Jul;1798(7):1444-56 [20056106] Langmuir. 2010 Jun 15;26(12):10084-92 [20355709] Mol Membr Biol. 2010 Oct;27(7):364-81 [20939770] Biochim Biophys Acta. 2011 Jan;1808(1):117-26 [20691151] Annu Rev Biochem. 2000;69:531-69 [10966468] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ar2001843 ER - TY - JOUR T1 - cSSMD: assessing collective activity for addressing off-target effects in genome-scale RNA interference screens AN - 915486009; 16101719 AB - Motivation: Off-target activity commonly exists in RNA interference (RNAi) screens and often generates false positives. Existing analytic methods for addressing the off-target effects are demonstrably inadequate in RNAi confirmatory screens.Results: Here, we present an analytic method assessing the collective activity of multiple short interfering RNAs (siRNAs) targeting a gene. Using this method, we can not only reduce the impact of off-target activities, but also evaluate the specific effect of an siRNA, thus providing information about potential off-target effects. Using in-house RNAi screens, we demonstrate that our method obtains more reasonable and sensible results than current methods such as the redundant siRNA activity (RSA) method, the RNAi gene enrichment ranking (RIGER) method, the frequency approach and the t-test. JF - Bioinformatics AU - Zhang, Xiaohua Douglas AU - Santini, Francesca AU - Lacson, Raul AU - Marine, Shane D AU - Wu, Qian AU - Benetti, Luca AU - Yang, Ruojing AU - McCampbell, Alex AU - Berger, Joel P AU - Toolan, Dawn M AU - Stec, Erica M AU - Holder, Daniel J AU - Soper, Keith A AU - Heyse, Joseph F AU - Ferrer, Marc AD - super(1)Biometrics Research, Merck Research Laboratories, West Point, PA 19486, super(2)Automated Biotechnology, Merck Research Laboratories, North Wales, PA 19454, super(3)Biostatistics, University of Pennsylvania, Philadelphia, PA, super(4)Vaccine Manufacturing Sciences and Commercialization, Merck Manufacturing Division, West Point, PA 19486, super(5)Diabetes, Merck Research Laboratories, Rahway, NJ 07065, super(6)Neurology, Merck Research Laboratories, West Point, PA 19486, super(7)BARDS, Merck Research Laboratories, West Point, PA 19486 and super(8)Chemical Genomics Center, National Institutes of Health, Rockville, MD, USA, Y1 - 2011/10/15/ PY - 2011 DA - 2011 Oct 15 SP - 2775 EP - 2781 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 27 IS - 20 SN - 1367-4803, 1367-4803 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Data processing KW - siRNA KW - RNA-mediated interference KW - Bioinformatics KW - Internet KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/915486009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=cSSMD%3A+assessing+collective+activity+for+addressing+off-target+effects+in+genome-scale+RNA+interference+screens&rft.au=Zhang%2C+Xiaohua+Douglas%3BSantini%2C+Francesca%3BLacson%2C+Raul%3BMarine%2C+Shane+D%3BWu%2C+Qian%3BBenetti%2C+Luca%3BYang%2C+Ruojing%3BMcCampbell%2C+Alex%3BBerger%2C+Joel+P%3BToolan%2C+Dawn+M%3BStec%2C+Erica+M%3BHolder%2C+Daniel+J%3BSoper%2C+Keith+A%3BHeyse%2C+Joseph+F%3BFerrer%2C+Marc&rft.aulast=Zhang&rft.aufirst=Xiaohua&rft.date=2011-10-15&rft.volume=27&rft.issue=20&rft.spage=2775&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtr474 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Genomes; Data processing; siRNA; RNA-mediated interference; Bioinformatics; Internet DO - http://dx.doi.org/10.1093/bioinformatics/btr474 ER - TY - JOUR T1 - SPREAD: spatial phylogenetic reconstruction of evolutionary dynamics AN - 915484275; 16101727 AB - Summary: SPREAD is a user-friendly, cross-platform application to analyze and visualize Bayesian phylogeographic reconstructions incorporating spatial-temporal diffusion. The software maps phylogenies annotated with both discrete and continuous spatial information and can export high-dimensional posterior summaries to keyhole markup language (KML) for animation of the spatial diffusion through time in virtual globe software. In addition, SPREAD implements Bayes factor calculation to evaluate the support for hypotheses of historical diffusion among pairs of discrete locations based on Bayesian stochastic search variable selection estimates. SPREAD takes advantage of multicore architectures to process large joint posterior distributions of phylogenies and their spatial diffusion and produces visualizations as compelling and interpretable statistical summaries for the different spatial projections. JF - Bioinformatics AU - Bielejec, Filip AU - Rambaut, Andrew AU - Suchard, Marc A AU - Lemey, Philippe AD - super(1)Rega Institute for Medical Research, Clinical and Epidemiological Virology Section, Katholieke Universiteit Leuven, Leuven, Belgium, super(2)Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK, super(3)Fogarty International Center, National Institutes of Health, Bethesda, MD, super(4)Department of Biomathematics, super(5)Department of Biostatistics and super(6)Department of Human Genetics, University of California, Los Angeles, USA, Y1 - 2011/10/15/ PY - 2011 DA - 2011 Oct 15 SP - 2910 EP - 2912 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 27 IS - 20 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Phylogeny KW - Statistics KW - Bayesian analysis KW - spatial discrimination KW - Maps KW - Stochasticity KW - Joints KW - Computer programs KW - software KW - Diffusion KW - Language KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/915484275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=SPREAD%3A+spatial+phylogenetic+reconstruction+of+evolutionary+dynamics&rft.au=Bielejec%2C+Filip%3BRambaut%2C+Andrew%3BSuchard%2C+Marc+A%3BLemey%2C+Philippe&rft.aulast=Bielejec&rft.aufirst=Filip&rft.date=2011-10-15&rft.volume=27&rft.issue=20&rft.spage=2910&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtr481 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Phylogeny; Computer programs; software; Statistics; Bayesian analysis; spatial discrimination; Language; Diffusion; Bioinformatics; Maps; Stochasticity; Joints DO - http://dx.doi.org/10.1093/bioinformatics/btr481 ER - TY - JOUR T1 - Tuberculosis Biomarker and Surrogate Endpoint Research Roadmap AN - 900337527; 21737585 AB - The Centers for Disease Control and Prevention and National Institutes of Health convened a multidisciplinary meeting to discuss surrogate markers of treatment response in tuberculosis. The goals were to assess recent surrogate marker research and to provide specific recommendations for (1) the qualification and validation of biomarkers of treatment outcome; (2) the standardization of specimen and data collection for future clinical trials, including a minimum set of samples and collection time points; and (3) the creation ofa specimen repository to support biomarker testing. This article summarizes these recommendations and provides a roadmap for their implementation. JF - American Journal of Respiratory and Critical Care Medicine AU - Nahid, Payam AU - Saukkonen, Jussi AU - Mac Kenzie, William R AU - Johnson, John L AU - Phillips, Patrick P J AU - Andersen, Janet AU - Bliven-Sizemore, Erin AU - Belisle, John T AU - Boom, W Henry AU - Luetkemeyer, Annie AU - Campbell, Thomas B AU - Eisenach, Kathleen D AU - Hafner, Richard AU - Lennox, Jeffrey L AU - Makhene, Mamodikoe AU - Swindells, Susan AU - Villarino, M Elsa AU - Weiner, Marc AU - Benson, Constance AU - Burman, William Y1 - 2011/10/15/ PY - 2011 DA - 2011 Oct 15 SP - 972 EP - 9 CY - New York PB - American Thoracic Society VL - 184 IS - 8 SN - 1073449X KW - Medical Sciences--Respiratory Diseases KW - Antitubercular Agents KW - Biological Markers KW - Humans KW - Treatment Outcome KW - Biological Specimen Banks KW - Antitubercular Agents -- therapeutic use KW - Biological Markers -- metabolism KW - Tuberculosis -- metabolism KW - Biological Markers -- analysis KW - Tuberculosis -- drug therapy KW - Tuberculosis -- genetics KW - Specimen Handling -- standards KW - Tuberculosis -- immunology KW - Clinical Trials as Topic -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900337527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Tuberculosis+Biomarker+and+Surrogate+Endpoint+Research+Roadmap&rft.au=Nahid%2C+Payam%3BSaukkonen%2C+Jussi%3BMac+Kenzie%2C+William+R%3BJohnson%2C+John+L%3BPhillips%2C+Patrick+P+J%3BAndersen%2C+Janet%3BBliven-Sizemore%2C+Erin%3BBelisle%2C+John+T%3BBoom%2C+W+Henry%3BLuetkemeyer%2C+Annie%3BCampbell%2C+Thomas+B%3BEisenach%2C+Kathleen+D%3BHafner%2C+Richard%3BLennox%2C+Jeffrey+L%3BMakhene%2C+Mamodikoe%3BSwindells%2C+Susan%3BVillarino%2C+M+Elsa%3BWeiner%2C+Marc%3BBenson%2C+Constance%3BBurman%2C+William&rft.aulast=Nahid&rft.aufirst=Payam&rft.date=2011-10-15&rft.volume=184&rft.issue=8&rft.spage=972&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Oct 15, 2011 N1 - Last updated - 2017-01-07 ER - TY - JOUR T1 - Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates. AN - 898504800; 21998010 AB - To enable antibodies to function as cytotoxic anticancer agents, they are modified either via attachment to protein toxins or highly potent, low-molecular-weight drugs. Such molecules, termed immunotoxins and antibody-drug conjugates, respectively, represent a second revolution in antibody-mediated cancer therapy. Thus, highly toxic compounds are delivered to the interior of cancer cells based on antibody specificity for cell-surface target antigens. JF - Cancer research AU - FitzGerald, David J AU - Wayne, Alan S AU - Kreitman, Robert J AU - Pastan, Ira AD - Laboratory of Molecular Biology, National Cancer Institute, NIH, Bethesda, Maryland 20892-4264, USA. Y1 - 2011/10/15/ PY - 2011 DA - 2011 Oct 15 SP - 6300 EP - 6309 VL - 71 IS - 20 KW - Antigens, CD KW - 0 KW - Antigens, CD19 KW - Antigens, CD3 KW - Antigens, Differentiation, Myelomonocytic KW - Antineoplastic Agents KW - Bacterial Toxins KW - CD22 protein, human KW - CD33 protein, human KW - Cd33 protein, mouse KW - Exotoxins KW - IL3RA protein, human KW - Immunotoxins KW - Interleukin-3 Receptor alpha Subunit KW - Receptors, Interleukin-2 KW - SDC1 protein, human KW - Sialic Acid Binding Ig-like Lectin 2 KW - Sialic Acid Binding Ig-like Lectin 3 KW - Syndecan-1 KW - immunotoxin HA22 KW - Index Medicus KW - Animals KW - Antigens, CD19 -- immunology KW - Humans KW - Clinical Trials as Topic KW - Mice KW - Receptors, Interleukin-2 -- immunology KW - Antigens, CD3 -- immunology KW - Syndecan-1 -- immunology KW - Sialic Acid Binding Ig-like Lectin 2 -- immunology KW - Interleukin-3 Receptor alpha Subunit -- immunology KW - Bacterial Toxins -- therapeutic use KW - Antigens, Differentiation, Myelomonocytic -- immunology KW - Exotoxins -- therapeutic use KW - Antigens, CD -- immunology KW - Immunotoxins -- chemistry KW - Antineoplastic Agents -- immunology KW - Immunotoxins -- immunology KW - Hematologic Neoplasms -- drug therapy KW - Immunotoxins -- therapeutic use KW - Hematologic Neoplasms -- immunology KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/898504800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Treatment+of+hematologic+malignancies+with+immunotoxins+and+antibody-drug+conjugates.&rft.au=FitzGerald%2C+David+J%3BWayne%2C+Alan+S%3BKreitman%2C+Robert+J%3BPastan%2C+Ira&rft.aulast=FitzGerald&rft.aufirst=David&rft.date=2011-10-15&rft.volume=71&rft.issue=20&rft.spage=6300&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-11-1374 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-12 N1 - Date created - 2011-10-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Blood. 1999 Nov 15;94(10):3340-8 [10552943] J Clin Oncol. 2012 Aug 1;30(22):2776-82 [22753910] J Clin Oncol. 2000 Apr;18(8):1622-36 [10764422] Clin Cancer Res. 2000 Apr;6(4):1302-13 [10778955] Clin Cancer Res. 2000 Apr;6(4):1476-87 [10778980] Clin Cancer Res. 2001 Jun;7(6):1490-6 [11410481] N Engl J Med. 2001 Jul 26;345(4):241-7 [11474661] Clin Cancer Res. 2002 Apr;8(4):995-1002 [11948105] Blood. 1993 Nov 1;82(9):2624-33 [8219217] Cancer Immunol Immunother. 1994 Dec;39(6):367-74 [8001024] Blood. 1997 Sep 1;90(5):2020-6 [9292538] Bioconjug Chem. 1998 Nov-Dec;9(6):736-43 [9815167] Int J Cancer. 1999 Mar 31;81(1):148-55 [10077166] Leukemia. 2005 Feb;19(2):176-82 [15592433] Blood. 2005 Jul 15;106(2):454-7 [15811959] Blood. 2005 Aug 15;106(4):1183-8 [15886328] Semin Oncol. 2006 Feb;33(1 Suppl 3):S11-6 [16516670] Br J Haematol. 2006 Apr;133(2):141-51 [16611304] Cancer. 2006 May 15;106(10):2158-64 [16586495] J Pediatr Hematol Oncol. 2006 Apr;28(4):210-5 [16679917] Nat Rev Cancer. 2006 Jul;6(7):559-65 [16794638] Annu Rev Med. 2007;58:221-37 [17059365] Br J Haematol. 2007 Feb;136(3):439-47 [17233846] Leuk Lymphoma. 2007 Dec;48(12):2397-402 [17943599] Leuk Lymphoma. 2008 Mar;49(3):543-53 [18297533] J Clin Oncol. 2008 May 10;26(14):2390-3295 [18467731] Cancer Immunol Immunother. 2008 Aug;57(8):1225-39 [18256829] Cancer Res. 2008 Aug 1;68(15):6300-5 [18676854] Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11311-6 [18678888] Bioconjug Chem. 2008 Oct;19(10):1960-3 [18803412] Br J Haematol. 2008 Nov;143(4):541-7 [18759760] Clin Cancer Res. 2009 Feb 1;15(3):832-9 [19188153] Curr Drug Targets. 2009 Feb;10(2):104-9 [19199905] Cancer Res. 2009 Mar 15;69(6):2358-64 [19258515] Blood. 2009 Apr 16;113(16):3792-800 [18988862] Blood. 2009 May 14;113(20):4903-13 [19124831] Cancer Res. 2009 Jun 15;69(12):4941-4 [19509221] Clin Cancer Res. 2009 Jun 15;15(12):4028-37 [19509164] J Clin Oncol. 2009 Jun 20;27(18):2983-90 [19414673] Leuk Res. 2009 Sep;33(9):1233-42 [19327829] BMC Cancer. 2009;9:199 [19549303] Clin Cancer Res. 2009 Aug 15;15(16):5274-9 [19671873] J Pediatr Hematol Oncol. 2009 Dec;31(12):936-41 [19875969] MAbs. 2009 May-Jun;1(3):281-7 [20065645] MAbs. 2009 Nov-Dec;1(6):548-51 [20068397] Clin Cancer Res. 2010 Feb 1;16(3):888-97 [20086002] Cancer. 2010 Feb 15;116(4 Suppl):1126-33 [20127945] Clin Cancer Res. 2010 Mar 15;16(6):1894-903 [20215554] Blood. 2010 Apr 1;115(13):2586-91 [20103782] J Clin Oncol. 2010 Apr 10;28(11):1870-7 [20212249] J Clin Oncol. 2010 Apr 20;28(12):2085-93 [20308665] Nat Rev Immunol. 2010 May;10(5):317-27 [20414205] Methods Mol Biol. 2010;651:157-75 [20686966] Curr Opin Chem Biol. 2010 Aug;14(4):529-37 [20643572] Blood. 2010 Aug 19;116(7):1035-44 [20439624] N Engl J Med. 2010 Nov 4;363(19):1812-21 [21047225] Cancer Sci. 2012 May;103(5):933-8 [22335424] J Clin Oncol. 2012 Jun 20;30(18):2190-6 [22614995] Leukemia. 2000 Apr;14(4):576-85 [10764142] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-11-1374 ER - TY - JOUR T1 - Inactivation of CHEK1 and EI24 is associated with the development of invasive cervical carcinoma: clinical and prognostic implications. AN - 1022560018; 21154811 AB - To understand the importance of frequent deletion of chromosomal 11q23.3-24.3 region in cervical carcinogenesis, alterations (deletion/methylation/mutation/expression) of the candidate genes LOH11CR2A, EI24 and CHEK1 located in the region were analyzed in 29 cervical intraepithelial neoplasia (CIN), 112 cervical carcinoma (CACX) samples and two CACX cell lines. The deletion frequency of these genes was low in CIN than in CACX [CIN: CHEK1: 28%, EI24: 21%, LOH11CR2A: 15% and CACX: CHEK1: 51%, EI24: 41%, LOH11CR2A: 36%]. Similar trend was seen in promoter methylation of these genes [CIN: CHEK1: 10%, EI24: 3%, LOH11CR2A: 3% and CACX: CHEK1: 55%, EI24: 31%, LOH11CR2A: 14%]. Mutations of the genes are a rare event. Overall alterations (deletion and methylation) of CHEK1 and EI24 were associated with progression of CACX. Quantitative mRNA expression analysis showed reduced expression of the three genes in concordance to their molecular alterations. A shorter isoform of CHEK1 lacking exon 8, hence impaired in substrate binding capacity, was found in two samples. Immunohistochemical analysis showed nuclear expression of Chek1, p-Chek1 and Ei24 in tumor tissues, whereas the cell lines exhibited both nuclear and cytoplasmic expression of Chek1 and Ei24, as is also evident from Western blot analysis suggesting differential localization of the proteins. Alterations of CHEK1 and EI24 coupled with tumor stage and early sexual debut (≤ 19 years) predicted worst prognosis. Thus, our data suggest that inactivation of EI24 and CHEK1 through two independent mechanisms contributes to the development of CACX. Copyright © 2010 UICC. JF - International journal of cancer AU - Mazumder Indra, Dipanjana AU - Mitra, Sraboni AU - Singh, Ratnesh Kumar AU - Dutta, Sankhadeep AU - Roy, Anup AU - Mondal, Ranajit Kumar AU - Basu, Partha Sarathi AU - Roychoudhury, Susanta AU - Panda, Chinmay Kumar AD - Department of Oncogene Regulation, Chittaranjan National Cancer Institute, Kolkata, India. Y1 - 2011/10/15/ PY - 2011 DA - 2011 Oct 15 SP - 1859 EP - 1871 VL - 129 IS - 8 KW - Apoptosis Regulatory Proteins KW - 0 KW - EI24 protein, human KW - Neoplasm Proteins KW - Nuclear Proteins KW - VWA5A protein, human KW - Protein Kinases KW - EC 2.7.- KW - CHEK1 protein, human KW - EC 2.7.11.1 KW - Checkpoint Kinase 1 KW - Index Medicus KW - Gene Silencing KW - Humans KW - Prognosis KW - Disease Progression KW - Cell Line, Tumor KW - Recurrence KW - Chromosomes, Human, Pair 11 KW - Promoter Regions, Genetic KW - Cervical Intraepithelial Neoplasia -- genetics KW - DNA Methylation KW - Adult KW - Middle Aged KW - Mutation KW - Female KW - Nuclear Proteins -- genetics KW - Apoptosis Regulatory Proteins -- genetics KW - Uterine Cervical Neoplasms -- mortality KW - Neoplasm Proteins -- genetics KW - Protein Kinases -- genetics KW - Uterine Cervical Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1022560018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Inactivation+of+CHEK1+and+EI24+is+associated+with+the+development+of+invasive+cervical+carcinoma%3A+clinical+and+prognostic+implications.&rft.au=Mazumder+Indra%2C+Dipanjana%3BMitra%2C+Sraboni%3BSingh%2C+Ratnesh+Kumar%3BDutta%2C+Sankhadeep%3BRoy%2C+Anup%3BMondal%2C+Ranajit+Kumar%3BBasu%2C+Partha+Sarathi%3BRoychoudhury%2C+Susanta%3BPanda%2C+Chinmay+Kumar&rft.aulast=Mazumder+Indra&rft.aufirst=Dipanjana&rft.date=2011-10-15&rft.volume=129&rft.issue=8&rft.spage=1859&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.25849 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-09-13 N1 - Date created - 2012-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.25849 ER - TY - JOUR T1 - Active ERK1/2 protein interacts with the phosphorylated nuclear constitutive active/androstane receptor (CAR; NR1I3), repressing dephosphorylation and sequestering CAR in the cytoplasm. AN - 900633397; 21873423 AB - The nuclear constitutive active/androstane receptor (CAR) is inactivated and sequestered in the cytoplasm when Thr-38 is phosphorylated. Here, we have demonstrated that activated ERK1/2 interacts with phosphorylated CAR to repress dephosphorylation of Thr-38. The phosphorylation-dependent interaction between CAR and ERK1/2 was examined by co-immunoprecipitation experiments of ectopically expressed FLAG-tagged CAR T38A and CAR T38D mutants with endogenous phospho-ERK1/2 in Huh-7 cells. Phospho-ERK1/2 coprecipitated only the phosphorylation-mimicking CAR T38D mutant; this coprecipitation was mediated by the interaction with the xenochemical response signal peptide near the C terminus of CAR. This interaction increased after EGF treatment and decreased after treatment with the MEK inhibitor U0126 as well as after knockdown of MEK1/2 by shRNA in Huh-7 cells. The phosphorylation levels of Thr-38 of CAR decreased in U0126-treated Huh-7 cells. Thus, activated ERK1/2 interacts with CAR and represses dephosphorylation of Thr-38, providing a cell signal-regulated mechanism for CAR activation. JF - The Journal of biological chemistry AU - Osabe, Makoto AU - Negishi, Masahiko AD - Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2011/10/14/ PY - 2011 DA - 2011 Oct 14 SP - 35763 EP - 35769 VL - 286 IS - 41 KW - Butadienes KW - 0 KW - Enzyme Inhibitors KW - Nitriles KW - Protein Sorting Signals KW - Receptors, Cytoplasmic and Nuclear KW - U 0126 KW - constitutive androstane receptor KW - MAP2K2 protein, human KW - EC 2.7.1.- KW - MAPK1 protein, human KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 1 KW - Mitogen-Activated Protein Kinase 3 KW - MAP Kinase Kinase 1 KW - EC 2.7.12.2 KW - MAP Kinase Kinase 2 KW - MAP2K1 protein, human KW - Map2k1 protein, mouse KW - Map2k2 protein, mouse KW - Index Medicus KW - MAP Kinase Kinase 2 -- metabolism KW - Animals KW - Humans KW - Enzyme Activation -- physiology KW - MAP Kinase Kinase 2 -- genetics KW - Phosphorylation -- physiology KW - Enzyme Activation -- drug effects KW - Mice, Inbred C3H KW - MAP Kinase Kinase 1 -- metabolism KW - Protein Sorting Signals -- physiology KW - Protein Transport -- physiology KW - Amino Acid Substitution KW - Male KW - MAP Kinase Kinase 1 -- genetics KW - Nitriles -- pharmacology KW - Protein Transport -- drug effects KW - Mice KW - Mutation, Missense KW - Phosphorylation -- drug effects KW - Butadienes -- pharmacology KW - MAP Kinase Kinase 1 -- antagonists & inhibitors KW - MAP Kinase Kinase 2 -- antagonists & inhibitors KW - Enzyme Inhibitors -- pharmacology KW - Protein Structure, Tertiary KW - Cell Line KW - Mitogen-Activated Protein Kinase 3 -- metabolism KW - Mitogen-Activated Protein Kinase 1 -- genetics KW - Mitogen-Activated Protein Kinase 3 -- genetics KW - Cytoplasm -- genetics KW - Cytoplasm -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Mitogen-Activated Protein Kinase 1 -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900633397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Active+ERK1%2F2+protein+interacts+with+the+phosphorylated+nuclear+constitutive+active%2Fandrostane+receptor+%28CAR%3B+NR1I3%29%2C+repressing+dephosphorylation+and+sequestering+CAR+in+the+cytoplasm.&rft.au=Osabe%2C+Makoto%3BNegishi%2C+Masahiko&rft.aulast=Osabe&rft.aufirst=Makoto&rft.date=2011-10-14&rft.volume=286&rft.issue=41&rft.spage=35763&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M111.284596 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-12 N1 - Date created - 2011-10-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Pharmacol. 2007 May;71(5):1217-21 [17314319] Biochem J. 2007 Feb 1;401(3):735-41 [17032173] Biochem Biophys Res Commun. 2008 May 16;369(4):1027-33 [18331826] Trends Endocrinol Metab. 2009 Aug;20(6):273-9 [19595610] Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18831-6 [19850873] J Biol Chem. 2009 Dec 11;284(50):34785-92 [19858220] PLoS One. 2010;5(4):e10121 [20404936] Annu Rev Pharmacol Toxicol. 2001;41:123-43 [11264453] Mol Cell Biol. 2001 Apr;21(8):2838-46 [11283262] Mol Pharmacol. 2002 Jun;61(6):1284-8 [12021388] Mol Pharmacol. 2004 Jan;65(1):172-80 [14722249] Mol Cell Biol. 2004 Sep;24(18):7931-40 [15340055] Cancer Res. 2004 Oct 15;64(20):7197-200 [15492232] Mol Cell Biol. 1998 Oct;18(10):5652-8 [9742082] J Biol Chem. 1999 Mar 5;274(10):6043-6 [10037683] Mol Cell Biol. 1999 Sep;19(9):6318-22 [10454578] Mol Pharmacol. 2006 Dec;70(6):1925-34 [16988011] Drug Metab Pharmacokinet. 2008;23(1):8-13 [18305370] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M111.284596 ER - TY - JOUR T1 - Von Hippel-Lindau (VHL) Inactivation in Sporadic Clear Cell Renal Cancer: Associations with Germline VHL Polymorphisms and Etiologic Risk Factors AN - 920806902; 16207813 AB - Renal tumor heterogeneity studies have utilized the von Hippel-Lindau VHL gene to classify disease into molecularly defined subtypes to examine associations with etiologic risk factors and prognosis. The aim of this study was to provide a comprehensive analysis of VHL inactivation in clear cell renal tumors (ccRCC) and to evaluate relationships between VHL inactivation subgroups with renal cancer risk factors and VHL germline single nucleotide polymorphisms (SNPs). VHL genetic and epigenetic inactivation was examined among 507 sporadic RCC/470 ccRCC cases using endonuclease scanning and using bisulfite treatment and Sanger sequencing across 11 CpG sites within the VHL promoter. Case-only multivariate analyses were conducted to identify associations between alteration subtypes and risk factors. VHL inactivation, either through sequence alterations or promoter methylation in tumor DNA, was observed among 86.6% of ccRCC cases. Germline VHL SNPs and a haplotype were associated with promoter hypermethylation in tumor tissue (OR=6.10; 95% CI: 2.28-16.35, p=3.76E-4, p-global=8E-5). Risk of having genetic VHL inactivation was inversely associated with smoking due to a higher proportion of wild-type ccRCC tumors [former: OR=0.70 (0.20-1.31) and current: OR=0.56 (0.32-0.99); P-trend=0.04]. Alteration prevalence did not differ by histopathologic characteristics or occupational exposure to trichloroethylene. ccRCC cases with particular VHL germline polymorphisms were more likely to have VHL inactivation through promoter hypermethylation than through sequence alterations in tumor DNA, suggesting that the presence of these SNPs may represent an example of facilitated epigenetic variation (an inherited propensity towards epigenetic variation) in renal tissue. A proportion of tumors from current smokers lacked VHL alterations and may represent a biologically distinct clinical entity from inactivated cases. In a large case-series of 470 sporadic clear cell renal cancer (ccRCC) cases, we examined von Hippel-Lindau (VHL) inactivation as a biomarker of tumor heterogeneity. Germline alterations of the VHL gene were identified and have been found in most families with VHL disease, a hereditary syndrome associated with ccRCC. In sporadic disease, VHL alterations have been reported in up to 91% of cases. Here, we observed a high prevalence of VHL inactivation through both genetic and epigenetic mechanisms that were highly associated with ccRCC. VHL inactivation through promoter hypermethylation in tumors was associated with inherited polymorphisms selected to capture common variation across the VHL locus. A high-risk haplotype associated with promoter hypermethylation in tumor DNA was identified. These findings suggest that the presence of these polymorphisms and VHL promoter hypermethylation may represent an example of an inherited propensity toward epigenetic variation and potential silencing of the VHL gene in tumor tissue. This result could have translational implications, as individuals with the high-risk haplotype could be targeted for increased surveillance. Smokers had a higher prevalence of tumors without detectable VHL sequence alteration or epigenetic inactivation. Such tumors may be biologically distinct and have demonstrated a poorer prognosis compared to VHL inactivated cases. JF - PLoS Genetics AU - Moore, Lee E AU - Nickerson, Michael L AU - Brennan, Paul AU - Toro, Jorge R AU - Jaeger, Erich AU - Rinsky, Jessica AU - Han, Summer S AU - Zaridze, David AU - Matveev, Vsevolod AU - Janout, Vladimir AU - Kollarova, Hellena AU - Bencko, Vladimir AU - Navratilova, Marie AU - Szeszenia-Dabrowska, Neonilia AU - Mates, Dana AU - Schmidt, Laura S AU - Lenz, Petra AU - Karami, Sara AU - Linehan, WMarston AU - Merino, Maria AU - Chanock, Stephen AU - Boffetta, Paolo AU - Chow, Wong-Ho AU - Waldman, Frederic M AU - Rothman, Nathaniel AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2011/10/13/ PY - 2011 DA - 2011 Oct 13 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 United States VL - 7 IS - 0 SN - 1553-7390, 1553-7390 KW - Biochemistry Abstracts 2: Nucleic Acids; Risk Abstracts; Health & Safety Science Abstracts; Genetics Abstracts KW - inactivation KW - Translation KW - Gene polymorphism KW - Nucleotide sequence KW - Bisulfite KW - tumors KW - Neoplasia KW - Genetics KW - Promoters KW - Smoking KW - Haplotypes KW - Multivariate analysis KW - epigenetics KW - Risk factors KW - DNA methylation KW - Risk groups KW - Trichloroethylene KW - Endonuclease KW - Occupational exposure KW - Bioindicators KW - Prognosis KW - Clear cells KW - haplotypes KW - CpG islands KW - Tumors KW - VHL protein KW - biomarkers KW - Cancer KW - Scanning KW - Single-nucleotide polymorphism KW - DNA KW - Kidney KW - N 14820:DNA Metabolism & Structure KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920806902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Genetics&rft.atitle=Von+Hippel-Lindau+%28VHL%29+Inactivation+in+Sporadic+Clear+Cell+Renal+Cancer%3A+Associations+with+Germline+VHL+Polymorphisms+and+Etiologic+Risk+Factors&rft.au=Moore%2C+Lee+E%3BNickerson%2C+Michael+L%3BBrennan%2C+Paul%3BToro%2C+Jorge+R%3BJaeger%2C+Erich%3BRinsky%2C+Jessica%3BHan%2C+Summer+S%3BZaridze%2C+David%3BMatveev%2C+Vsevolod%3BJanout%2C+Vladimir%3BKollarova%2C+Hellena%3BBencko%2C+Vladimir%3BNavratilova%2C+Marie%3BSzeszenia-Dabrowska%2C+Neonilia%3BMates%2C+Dana%3BSchmidt%2C+Laura+S%3BLenz%2C+Petra%3BKarami%2C+Sara%3BLinehan%2C+WMarston%3BMerino%2C+Maria%3BChanock%2C+Stephen%3BBoffetta%2C+Paolo%3BChow%2C+Wong-Ho%3BWaldman%2C+Frederic+M%3BRothman%2C+Nathaniel&rft.aulast=Moore&rft.aufirst=Lee&rft.date=2011-10-13&rft.volume=7&rft.issue=0&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Genetics&rft.issn=15537390&rft_id=info:doi/10.1371%2Fjournal.pgen.1002312 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Translation; Nucleotide sequence; Gene polymorphism; Bisulfite; Neoplasia; Smoking; Promoters; Haplotypes; epigenetics; Multivariate analysis; Risk factors; DNA methylation; Risk groups; Trichloroethylene; Endonuclease; Occupational exposure; Clear cells; Prognosis; Tumors; CpG islands; VHL protein; biomarkers; Cancer; Scanning; Single-nucleotide polymorphism; Kidney; DNA; Bioindicators; inactivation; Genetics; tumors; haplotypes DO - http://dx.doi.org/10.1371/journal.pgen.1002312 ER - TY - CPAPER T1 - Finding genetic variants that underlie stuttering T2 - 61st Annual Meeting of the American Society of Human Genetics and the 12th International Congress of Human Genetics (ICHG 2011) AN - 1312981031; 6056289 JF - 61st Annual Meeting of the American Society of Human Genetics and the 12th International Congress of Human Genetics (ICHG 2011) AU - Drayna, D Y1 - 2011/10/11/ PY - 2011 DA - 2011 Oct 11 KW - Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312981031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Meeting+of+the+American+Society+of+Human+Genetics+and+the+12th+International+Congress+of+Human+Genetics+%28ICHG+2011%29&rft.atitle=Finding+genetic+variants+that+underlie+stuttering&rft.au=Drayna%2C+D&rft.aulast=Drayna&rft.aufirst=D&rft.date=2011-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Meeting+of+the+American+Society+of+Human+Genetics+and+the+12th+International+Congress+of+Human+Genetics+%28ICHG+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ichg2011.org/program_guide/files/assets/downloads/publication.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The function of genome-wide meiosisspecific epigenetic marks in recombination T2 - 61st Annual Meeting of the American Society of Human Genetics and the 12th International Congress of Human Genetics (ICHG 2011) AN - 1312909078; 6056174 JF - 61st Annual Meeting of the American Society of Human Genetics and the 12th International Congress of Human Genetics (ICHG 2011) AU - Camerini-Otero, R Y1 - 2011/10/11/ PY - 2011 DA - 2011 Oct 11 KW - Recombination KW - epigenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312909078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Meeting+of+the+American+Society+of+Human+Genetics+and+the+12th+International+Congress+of+Human+Genetics+%28ICHG+2011%29&rft.atitle=The+function+of+genome-wide+meiosisspecific+epigenetic+marks+in+recombination&rft.au=Camerini-Otero%2C+R&rft.aulast=Camerini-Otero&rft.aufirst=R&rft.date=2011-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Meeting+of+the+American+Society+of+Human+Genetics+and+the+12th+International+Congress+of+Human+Genetics+%28ICHG+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ichg2011.org/program_guide/files/assets/downloads/publication.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Simplified synthesis of isotopically labeled 5,5-dimethyl-pyrroline N-oxide. AN - 897812511; 21986521 AB - 5,5-Dimethylpyrroline N-oxide (15N) and 5,5-di(trideuteromethyl)pyrroline N-oxide were synthesized from the respective isotopically labeled 2-nitropropane analogs obtained from the reaction of sodium nitrate with 2-halopropanes. This facile, straightforward process allows synthesizing isotopically labeled DMPO analogs in a 4-step reaction without special equipment. JF - Molecules (Basel, Switzerland) AU - Leinisch, Fabian AU - Jiang, Jinjie AU - Deterding, Leesa J AU - Mason, Ronald P AD - Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA. leinischf@niehs.nih.gov Y1 - 2011/10/10/ PY - 2011 DA - 2011 Oct 10 SP - 8428 EP - 8436 VL - 16 IS - 10 KW - 5,5-dimethyl-pyrroline N-oxide KW - 0 KW - Carbon Isotopes KW - Cyclic N-Oxides KW - Nitrates KW - Nitrogen Isotopes KW - Nitroparaffins KW - Spin Labels KW - halopropane KW - 679-84-5 KW - sodium nitrate KW - 8M4L3H2ZVZ KW - 2-nitropropane KW - GKV234L2QH KW - Propane KW - T75W9911L6 KW - Index Medicus KW - Mass Spectrometry KW - Spin Trapping -- methods KW - Nitrogen Isotopes -- chemistry KW - Carbon Isotopes -- chemistry KW - Isotope Labeling KW - Nitrates -- chemistry KW - Propane -- analogs & derivatives KW - Cyclic N-Oxides -- chemical synthesis KW - Propane -- chemistry KW - Nitroparaffins -- chemistry KW - Cyclic N-Oxides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/897812511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecules+%28Basel%2C+Switzerland%29&rft.atitle=Simplified+synthesis+of+isotopically+labeled+5%2C5-dimethyl-pyrroline+N-oxide.&rft.au=Leinisch%2C+Fabian%3BJiang%2C+Jinjie%3BDeterding%2C+Leesa+J%3BMason%2C+Ronald+P&rft.aulast=Leinisch&rft.aufirst=Fabian&rft.date=2011-10-10&rft.volume=16&rft.issue=10&rft.spage=8428&rft.isbn=&rft.btitle=&rft.title=Molecules+%28Basel%2C+Switzerland%29&rft.issn=1420-3049&rft_id=info:doi/10.3390%2Fmolecules16108428 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-15 N1 - Date created - 2011-10-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: FEBS Lett. 2000 May 4;473(1):58-62 [10802059] Chem Biol Interact. 1989;70(1-2):167-72 [2544305] Free Radic Biol Med. 2009 Sep 1;47(5):568-76 [19482075] Free Radic Biol Med. 2005 Jan 1;38(1):125-35 [15589381] Mol Pharmacol. 1997 Dec;52(6):1081-6 [9415718] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3390/molecules16108428 ER - TY - JOUR T1 - Molecular targeting of CSN5 in human hepatocellular carcinoma: a mechanism of therapeutic response. AN - 896828061; 21499307 AB - Development of targeted therapy for hepatocellular carcinoma (HCC) remains a major challenge. We have recently identified an elevated expression of the fifth subunit of COP9 signalosome (CSN5) in early HCC as compared with dysplastic stage. In the present study, we explored the possibility of CSN5 being a potential therapeutic target for HCC. Our results show that CSN5 knockdown by small-interfering (si) RNA caused a strong induction of apoptosis and inhibition of cell-cycle progression in HCC cells in vitro. The down-regulation of CSN5 was sufficient to interfere with CSN function as evidenced by the accumulation of neddylated Cullin 1 and changes in the protein levels of CSN-controlled substrates SKP2, p53, p27 and nuclear factor-κB, albeit to a different degree depending on the HCC cell line, which could account for the CSN5 knockdown phenotype. The transcriptomic analysis of CSN5 knockdown signature showed that the anti-proliferative effect was driven by a common subset of molecular alterations including down-regulation of cyclin-dependent kinase 6 (CDK6) and integrin β1 (ITGB1), which were functionally interconnected with key oncogenic regulators MYC and TGFβ1 involved in the control of proliferation, apoptotic cell death and HCC progression. Consistent with microarray analysis, western blotting revealed that CSN5 depletion increased phosphorylation of Smad 2/3, key mediators of TGFβ1 signaling, decreased the protein levels of ITGB1, CDK6 and cyclin D1 and caused reduced expression of anti-apoptotic Bcl-2, while elevating the levels of pro-apoptotic Bak. A chemically modified variant of CSN5 siRNA was then selected for in vivo application based on the growth inhibitory effect and minimal induction of unwanted immune response. Systemic delivery of the CSN5 3/8 variant by stable-nucleic-acid-lipid particles significantly suppressed the tumor growth in Huh7-luc+ orthotopic xenograft model. Taken together, these results indicate that CSN5 has a pivotal role in HCC pathogenesis and maybe an attractive molecular target for systemic HCC therapy. JF - Oncogene AU - Lee, Y-H AU - Judge, A D AU - Seo, D AU - Kitade, M AU - Gómez-Quiroz, L E AU - Ishikawa, T AU - Andersen, J B AU - Kim, B-K AU - Marquardt, J U AU - Raggi, C AU - Avital, I AU - Conner, E A AU - MacLachlan, I AU - Factor, V M AU - Thorgeirsson, S S AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD, USA. Y1 - 2011/10/06/ PY - 2011 DA - 2011 Oct 06 SP - 4175 EP - 4184 VL - 30 IS - 40 KW - Intracellular Signaling Peptides and Proteins KW - 0 KW - RNA, Small Interfering KW - Peptide Hydrolases KW - EC 3.4.- KW - COPS5 protein, human KW - EC 3.4.-.- KW - Index Medicus KW - Gene Knockdown Techniques KW - Down-Regulation KW - Humans KW - RNA, Small Interfering -- genetics KW - Cell Line, Tumor KW - Cell Division KW - Intracellular Signaling Peptides and Proteins -- genetics KW - Liver Neoplasms -- pathology KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Intracellular Signaling Peptides and Proteins -- metabolism KW - Carcinoma, Hepatocellular -- drug therapy KW - Liver Neoplasms -- drug therapy KW - Peptide Hydrolases -- metabolism KW - Carcinoma, Hepatocellular -- pathology KW - Peptide Hydrolases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896828061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Molecular+targeting+of+CSN5+in+human+hepatocellular+carcinoma%3A+a+mechanism+of+therapeutic+response.&rft.au=Lee%2C+Y-H%3BJudge%2C+A+D%3BSeo%2C+D%3BKitade%2C+M%3BG%C3%B3mez-Quiroz%2C+L+E%3BIshikawa%2C+T%3BAndersen%2C+J+B%3BKim%2C+B-K%3BMarquardt%2C+J+U%3BRaggi%2C+C%3BAvital%2C+I%3BConner%2C+E+A%3BMacLachlan%2C+I%3BFactor%2C+V+M%3BThorgeirsson%2C+S+S&rft.aulast=Lee&rft.aufirst=Y-H&rft.date=2011-10-06&rft.volume=30&rft.issue=40&rft.spage=4175&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2011.126 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-22 N1 - Date created - 2011-10-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Biotechnol. 2005 Apr;23(4):457-62 [15778705] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Semin Liver Dis. 2005;25(2):212-25 [15918149] Hepatology. 2005 Jun;41(6):1349-56 [15880588] Nat Biotechnol. 2005 Aug;23(8):1002-7 [16041363] Cancer Lett. 2005 Nov 18;229(2):157-69 [16125305] Hepatology. 2005 Nov;42(5):1208-36 [16250051] Mol Ther. 2006 Mar;13(3):494-505 [16343994] Gene Ther. 2006 Mar;13(6):464-77 [16341059] Nat Genet. 2006 Apr;38(4):421-30 [16518402] Nature. 2006 May 4;441(7089):111-4 [16565705] FEBS Lett. 2006 Oct 30;580(25):5836-44 [17027978] Nat Chem Biol. 2006 Dec;2(12):711-9 [17108989] Gene Ther. 2006 Apr;13(7):583-4 [17526070] Cancer Res. 2008 Jan 15;68(2):506-15 [18199546] J Exp Med. 2008 Feb 18;205(2):465-77 [18268034] IDrugs. 2008 Apr;11(4):274-8 [18379962] N Engl J Med. 2008 Jul 24;359(4):378-90 [18650514] Hepatology. 2008 Oct;48(4):1312-27 [18821591] Cancer Res. 2008 Oct 15;68(20):8333-41 [18922905] Trends Biochem Sci. 2008 Dec;33(12):592-600 [18926707] Nat Rev Drug Discov. 2009 Feb;8(2):129-38 [19180106] J Clin Invest. 2009 Mar;119(3):661-73 [19229107] EMBO Rep. 2009 Apr;10(4):352-8 [19305390] Cancer Res. 2009 Apr 1;69(7):2775-82 [19276364] Genes Cells. 2009 Nov;14(11):1209-25 [19849719] Int J Cancer. 2010 Sep 1;127(6):1347-55 [20209494] Oncol Rep. 2004 Feb;11(2):277-84 [14719054] Am J Med. 2000 May;108(7):567-74 [10806286] J Hepatol. 2000 Dec;33(6):907-14 [11131452] Cancer Res. 2001 Mar 1;61(5):2129-37 [11280777] Nature. 2001 May 24;411(6836):494-8 [11373684] Nat Struct Biol. 2001 Sep;8(9):746-50 [11524674] Cell. 2001 Nov 16;107(4):465-76 [11719187] Clin Cancer Res. 2001 Dec;7(12):4130-5 [11751512] J Biol Chem. 2002 Jan 4;277(1):9-12 [11707426] Oncogene. 2002 Apr 11;21(16):2593-604 [11971194] Nat Genet. 2002 Aug;31(4):339-46 [12149612] Cancer Res. 2003 Jun 1;63(11):2977-81 [12782606] Hepatology. 2003 Jul;38(1):148-57 [12829997] Clin Cancer Res. 2003 Nov 15;9(15):5652-9 [14654548] Anticancer Res. 2003 Sep-Oct;23(5b):4121-5 [14666612] Nature. 2004 Mar 11;428(6979):190-3 [15014502] Mod Pathol. 2004 Jul;17(7):811-8 [15154004] Pathol Int. 2004 Sep;54(9):675-81 [15363035] Nature. 2004 Sep 16;431(7006):371-8 [15372045] Gastroenterology. 2004 Nov;127(5 Suppl 1):S51-5 [15508103] Nature. 1996 Oct 3;383(6599):453-7 [8837781] Nature. 1998 Feb 19;391(6669):806-11 [9486653] Mol Cell Biol. 1999 May;19(5):3654-63 [10207089] Mol Cell Biol. 1999 Jul;19(7):4672-83 [10373516] Pharm Res. 2005 Mar;22(3):362-72 [15835741] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/onc.2011.126 ER - TY - JOUR T1 - N-Alkyl-PEI-functionalized iron oxide nanoclusters for efficient siRNA delivery. AN - 894815598; 21861295 AB - Small-interfering RNA (siRNA) is an emerging class of therapeutics, which works by regulating the expression of a specific gene involved in disease progression. Despite the promises, effective transport of siRNA with minimal side effects remains a challenge. In this study, a nonviral nanoparticle gene carrier is developed and its efficiency for siRNA delivery and transfection is validated at both in vitro and in vivo levels. Such a nanocarrier, abbreviated as Alkyl-PEI2k-IO, was constructed with a core of iron oxide nanoparticles (IOs) and a shell of alkylated polyethyleneimine of 2000 Da [corrected] molecualr weight (Alkyl-PEI2k). It is found to be able to bind with siRNA, resulting in well-dispersed nanoparticles with a controlled clustering structure and narrow size distribution. Electrophoresis studies show that the Alkyl-PEI2k-IOs could retard siRNA completely at N:P ratios (i.e., PEI nitrogen to nucleic acid phosphate) above 10, protect siRNA from enzymatic degradation in serum, and release complexed siRNA efficiently in the presence of polyanionic heparin. The knockdown efficiency of the siRNA-loaded nanocarriers is assessed with 4T1 cells stably expressing luciferase (fluc-4T1) and further, with a fluc-4T1 xenograft model. Significant down-regulation of luciferase is observed, and unlike high-molecular-weight analogues, the Alkyl-PEI2k-coated IOs show good biocompatibility. In conclusion, Alkyl-PEI2k-IOs demonstrate highly efficient delivery of siRNA and an innocuous toxic profile, making it a potential carrier for gene therapy. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. JF - Small (Weinheim an der Bergstrasse, Germany) AU - Liu, Gang AU - Xie, Jin AU - Zhang, Fan AU - Wang, Zhiyong AU - Luo, Kui AU - Zhu, Lei AU - Quan, Qimeng AU - Niu, Gang AU - Lee, Seulki AU - Ai, Hua AU - Chen, Xiaoyuan AD - Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA. Y1 - 2011/10/04/ PY - 2011 DA - 2011 Oct 04 SP - 2742 EP - 2749 VL - 7 IS - 19 KW - Ferric Compounds KW - 0 KW - RNA, Small Interfering KW - ferric oxide KW - 1K09F3G675 KW - Polyethyleneimine KW - 9002-98-6 KW - Luciferases, Firefly KW - EC 1.13.12.7 KW - Index Medicus KW - Phantoms, Imaging KW - Animals KW - Luciferases, Firefly -- metabolism KW - Intracellular Space -- metabolism KW - Cell Death KW - Electrophoresis, Agar Gel KW - Mice KW - Cell Line, Tumor KW - Magnetic Resonance Spectroscopy KW - Gene Transfer Techniques KW - Polyethyleneimine -- analogs & derivatives KW - Ferric Compounds -- chemistry KW - Polyethyleneimine -- chemistry KW - RNA, Small Interfering -- metabolism KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/894815598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Small+%28Weinheim+an+der+Bergstrasse%2C+Germany%29&rft.atitle=N-Alkyl-PEI-functionalized+iron+oxide+nanoclusters+for+efficient+siRNA+delivery.&rft.au=Liu%2C+Gang%3BXie%2C+Jin%3BZhang%2C+Fan%3BWang%2C+Zhiyong%3BLuo%2C+Kui%3BZhu%2C+Lei%3BQuan%2C+Qimeng%3BNiu%2C+Gang%3BLee%2C+Seulki%3BAi%2C+Hua%3BChen%2C+Xiaoyuan&rft.aulast=Liu&rft.aufirst=Gang&rft.date=2011-10-04&rft.volume=7&rft.issue=19&rft.spage=2742&rft.isbn=&rft.btitle=&rft.title=Small+%28Weinheim+an+der+Bergstrasse%2C+Germany%29&rft.issn=1613-6829&rft_id=info:doi/10.1002%2Fsmll.201100825 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-23 N1 - Date created - 2011-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 1999 Oct 29;286(5441):950-2 [10542148] Acc Chem Res. 2008 Jun;41(6):749-59 [18507402] Nature. 2001 May 24;411(6836):494-8 [11373684] J Control Release. 2001 Jun 15;73(2-3):401-16 [11516515] Gene Ther. 2002 Jan;9(2):102-9 [11857068] Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14640-5 [12403826] Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9138-43 [12886020] Nature. 2004 Feb 26;427(6977):779-81 [14985734] Nature. 2004 Sep 16;431(7006):371-8 [15372045] Science. 1972 Mar 3;175(4025):949-55 [5061866] Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7297-301 [7638184] J Control Release. 1999 Aug 5;60(2-3):149-60 [10425321] Adv Genet. 2005;53:217-30 [16240995] Nat Med. 2006 Apr;12(4):401-9 [16582916] Nature. 2006 Apr 27;440(7088):1123 [16641981] J Control Release. 2006 May 15;112(2):257-70 [16574264] Cancer Gene Ther. 2006 Sep;13(9):819-29 [16424918] Nat Med. 2007 Mar;13(3):372-7 [17322898] Acc Chem Res. 2007 May;40(5):335-42 [17474708] Nat Rev Drug Discov. 2007 Jun;6(6):443-53 [17541417] Nat Rev Drug Discov. 2007 Jul;6(7):556-68 [17599085] J Gene Med. 2007 Oct;9(10):833-42 [17721874] J Drug Target. 2008 Feb;16(2):124-39 [18274933] Bioconjug Chem. 2008 Jul;19(7):1448-55 [18553894] Nat Rev Mol Cell Biol. 2009 Feb;10(2):126-39 [19165215] Clin Cancer Res. 2008 Oct 1;14(19):6137-45 [18829492] Biopolymers. 2008 Oct;89(10):881-8 [18521895] J Control Release. 2009 Feb 10;133(3):214-20 [18973779] Curr Med Chem. 2009;16(10):1278-94 [19355885] Int J Pharm. 2009 May 8;372(1-2):169-76 [19429277] J Nanosci Nanotechnol. 2009 Jan;9(1):378-85 [19441322] Mol Pharm. 2009 May-Jun;6(3):651-8 [19115957] Acc Chem Res. 2009 Aug 18;42(8):1097-107 [19476332] Chem Commun (Camb). 2010 Jan 21;46(3):433-5 [20066316] Small. 2010 Jan;6(2):239-46 [19924738] Biomaterials. 2010 Mar;31(7):1830-8 [19942284] Nat Mater. 2010 Mar;9(3):272-8 [20098433] Biomaterials. 2010 Apr;31(11):3016-22 [20092887] Curr Drug Targets. 2010 Mar;11(3):345-60 [20210759] Nature. 2010 Apr 15;464(7291):1067-70 [20305636] Contrast Media Mol Imaging. 2010 Mar-Apr;5(2):53-8 [20235146] Langmuir. 2010 May 18;26(10):7314-26 [20112951] Bioconjug Chem. 2010 May 19;21(5):836-43 [20438071] Bioconjug Chem. 2009 Mar 18;20(3):488-99 [19199781] Adv Mater. 2010 Jul 6;22(25):2729-42 [20473985] Expert Rev Mol Med. 2010;12:e26 [20716384] ACS Nano. 2010 Aug 24;4(8):4539-50 [20731437] Biomaterials. 2010 Nov;31(31):8032-42 [20673683] ACS Nano. 2010 Sep 28;4(9):5505-11 [20707386] Biomaterials. 2011 Jan;32(2):528-37 [20869767] Mol Pharm. 2010 Dec 6;7(6):1930-9 [20722417] Curr Drug Deliv. 2011 Jan;8(1):59-69 [21034421] Biomaterials. 2011 Mar;32(7):1890-905 [21167595] Erratum In: Small. 2011 Dec 2;7(23):3260 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/smll.201100825 ER - TY - CPAPER T1 - Para-aortic Nodal Clinical Target Volume Delineation in the Era of Particle Therapy T2 - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AN - 1313046628; 6068163 JF - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AU - Simone, C AU - O'Connell, J AU - Both, S AU - Mansueti, J AU - Christodouleas, J AU - Deville, C AU - McDonough, J AU - Vapiwala, N AU - Efstathiou, J AU - Bekelman, J Y1 - 2011/10/02/ PY - 2011 DA - 2011 Oct 02 KW - Particulates KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313046628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=Para-aortic+Nodal+Clinical+Target+Volume+Delineation+in+the+Era+of+Particle+Therapy&rft.au=Simone%2C+C%3BO%27Connell%2C+J%3BBoth%2C+S%3BMansueti%2C+J%3BChristodouleas%2C+J%3BDeville%2C+C%3BMcDonough%2C+J%3BVapiwala%2C+N%3BEfstathiou%2C+J%3BBekelman%2C+J&rft.aulast=Simone&rft.aufirst=C&rft.date=2011-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The Relationship of Post-Operative Breast Radiation Therapy to Physical Function T2 - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AN - 1313044395; 6067670 JF - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AU - Kesarwala, A AU - Pfalzer, L AU - O'Meara, W AU - Stout, N Y1 - 2011/10/02/ PY - 2011 DA - 2011 Oct 02 KW - Radiation therapy KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313044395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=The+Relationship+of+Post-Operative+Breast+Radiation+Therapy+to+Physical+Function&rft.au=Kesarwala%2C+A%3BPfalzer%2C+L%3BO%27Meara%2C+W%3BStout%2C+N&rft.aulast=Kesarwala&rft.aufirst=A&rft.date=2011-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Predictive Value of Tumor Recurrence Using Urinary Vascular Endothelial Growth Factor Levels in Patients Receiving Radiation Therapy for Glioblastoma T2 - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AN - 1313018164; 6066572 JF - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AU - Camphausen, K AU - Wang, M AU - Graves, C AU - Corn, B AU - Muanza, T AU - Howard, S AU - Mahadevan, A AU - Schultz, C AU - Haas, M AU - Mehta, M Y1 - 2011/10/02/ PY - 2011 DA - 2011 Oct 02 KW - Growth factors KW - Radiation therapy KW - Tumors KW - Urine KW - Glioblastoma KW - Vascular endothelial growth factor KW - Prediction KW - Therapy KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313018164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=Predictive+Value+of+Tumor+Recurrence+Using+Urinary+Vascular+Endothelial+Growth+Factor+Levels+in+Patients+Receiving+Radiation+Therapy+for+Glioblastoma&rft.au=Camphausen%2C+K%3BWang%2C+M%3BGraves%2C+C%3BCorn%2C+B%3BMuanza%2C+T%3BHoward%2C+S%3BMahadevan%2C+A%3BSchultz%2C+C%3BHaas%2C+M%3BMehta%2C+M&rft.aulast=Camphausen&rft.aufirst=K&rft.date=2011-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=&rft_id=info:doi/ L2 - https://www.astro.org/Meetings-and-Events/2011-Annual-Meeting/Meeting-Program/Schedule-of-Events.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Radiation Doses to the Esophagus from Radiotherapy Treatment for Breast Cancer during 1943-2001 T2 - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AN - 1313012159; 6067657 JF - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AU - Lamart, S AU - Morton, L AU - Simon, S AU - Curtis, R AU - Aleman, B AU - Smith, S AU - Weathers, R AU - Stovall, M Y1 - 2011/10/02/ PY - 2011 DA - 2011 Oct 02 KW - radiotherapy KW - Breast cancer KW - Radiation KW - Radiotherapy KW - Esophagus KW - Oesophagus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313012159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=Radiation+Doses+to+the+Esophagus+from+Radiotherapy+Treatment+for+Breast+Cancer+during+1943-2001&rft.au=Lamart%2C+S%3BMorton%2C+L%3BSimon%2C+S%3BCurtis%2C+R%3BAleman%2C+B%3BSmith%2C+S%3BWeathers%2C+R%3BStovall%2C+M&rft.aulast=Lamart&rft.aufirst=S&rft.date=2011-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Pre-clinical Evaluation of 177Lu-Labeled Trastuzumab Targeting HER2 for Radioimmunotherapeutic and Radioimmunodiagnostic Applications T2 - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AN - 1313001768; 6067315 JF - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AU - Ray, G AU - Baidoo, K AU - Keller, L AU - Milenic, D AU - Brechbiel, M Y1 - 2011/10/02/ PY - 2011 DA - 2011 Oct 02 KW - ErbB-2 protein KW - trastuzumab UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313001768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=Pre-clinical+Evaluation+of+177Lu-Labeled+Trastuzumab+Targeting+HER2+for+Radioimmunotherapeutic+and+Radioimmunodiagnostic+Applications&rft.au=Ray%2C+G%3BBaidoo%2C+K%3BKeller%2C+L%3BMilenic%2C+D%3BBrechbiel%2C+M&rft.aulast=Ray&rft.aufirst=G&rft.date=2011-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Radiation Therapy for Management of Patients with HTLV-1-associated Adult T-cell Leukemia/Lymphoma T2 - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AN - 1312958627; 6067897 JF - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AU - Simone, C AU - Stewart, D AU - Lita, E AU - Kreitman, R AU - Conlon, K AU - Janik, J AU - Morris, J AU - Kaushal, A Y1 - 2011/10/02/ PY - 2011 DA - 2011 Oct 02 KW - lymphoma KW - Radiation therapy KW - Leukemia KW - Lymphoma KW - Lymphocytes T KW - Therapy KW - Human T-lymphotropic virus KW - Human T-lymphotropic virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312958627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=Radiation+Therapy+for+Management+of+Patients+with+HTLV-1-associated+Adult+T-cell+Leukemia%2FLymphoma&rft.au=Simone%2C+C%3BStewart%2C+D%3BLita%2C+E%3BKreitman%2C+R%3BConlon%2C+K%3BJanik%2C+J%3BMorris%2C+J%3BKaushal%2C+A&rft.aulast=Simone&rft.aufirst=C&rft.date=2011-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Lack of Radiation-Induced Pulmonary Toxicity 25 years after Treatment with Breast Conservation Therapy or Mastectomy for Early-stage Breast Cancer: Results from the NCI Randomized Trial T2 - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AN - 1312955230; 6066348 JF - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AU - Simone, N AU - Simone, B AU - Simone, C AU - Dan, T AU - Ly, D. AU - Lita, E AU - Smith, S AU - Levine, S AU - Folio, L Y1 - 2011/10/02/ PY - 2011 DA - 2011 Oct 02 KW - Toxicity KW - Conservation KW - Breast cancer KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312955230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=Lack+of+Radiation-Induced+Pulmonary+Toxicity+25+years+after+Treatment+with+Breast+Conservation+Therapy+or+Mastectomy+for+Early-stage+Breast+Cancer%3A+Results+from+the+NCI+Randomized+Trial&rft.au=Simone%2C+N%3BSimone%2C+B%3BSimone%2C+C%3BDan%2C+T%3BLy%2C+D.%3BLita%2C+E%3BSmith%2C+S%3BLevine%2C+S%3BFolio%2C+L&rft.aulast=Simone&rft.aufirst=N&rft.date=2011-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=&rft_id=info:doi/ L2 - https://www.astro.org/Meetings-and-Events/2011-Annual-Meeting/Meeting-Program/Schedule-of-Events.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Intrarectal Amifostine Suspension During External Beam Radiotherapy For Prostate Cancer May Protect Against Long Term Toxicity T2 - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AN - 1312906999; 6068143 JF - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AU - Ko, C. AU - Menard, C AU - Ning, H AU - Lita, E AU - Smith, S AU - Pinto, P AU - Singh, A AU - Coleman, C AU - Camphausen, K AU - Kaushal, A Y1 - 2011/10/02/ PY - 2011 DA - 2011 Oct 02 KW - Toxicity KW - prostate cancer KW - radiotherapy KW - Amifostine KW - Radiotherapy KW - Prostate cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312906999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=Intrarectal+Amifostine+Suspension+During+External+Beam+Radiotherapy+For+Prostate+Cancer+May+Protect+Against+Long+Term+Toxicity&rft.au=Ko%2C+C.%3BMenard%2C+C%3BNing%2C+H%3BLita%2C+E%3BSmith%2C+S%3BPinto%2C+P%3BSingh%2C+A%3BColeman%2C+C%3BCamphausen%2C+K%3BKaushal%2C+A&rft.aulast=Ko&rft.aufirst=C.&rft.date=2011-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Direct and Mediated Effects of Two Theoretically Based Interventions to Increase Consumption of Fruits and Vegetables in the Healthy Body Healthy Spirit Trial AN - 927830337; 201120675 AB - This study tested the effects of two theory-based interventions to increase fruit and vegetable intake. Hypothesized intervention mediators included self-efficacy (SE), social support (SS), autonomous motivation (AM), and controlled motivation (CM). At baseline, 1,021 African American adults were recruited from 16 churches randomized to one comparison and two intervention groups: Group 1 (standard educational materials), Group 2 (culturally targeted materials), and Group 3 (culturally targeted materials and telephone-based motivational interviewing). A well-fitted model based on structural equation modeling-X2(df = 541, N = 353, 325) = 864.28, p < .001, normed fit index = .96, nonnormed fit index = .98, comparative fit index = .98, root mean square error of approximation = .042-demonstrated that AM was both a significant mediator and moderator. In the subgroup with low baseline AM, AM mediated 17% of the effect of the Group 3 intervention on fruit and vegetable intake. Conversely, SS, SE, and CM were not significant mediators. Implications related to theory and intervention development are discussed. [Reprinted by permission of Sage Publications Inc., copyright, the Society for Public Health Education.] JF - Health Education & Behavior AU - Shaikh, Abdul R AU - Vinokur, Amiram D AU - Yaroch, Amy L AU - Williams, Geoffrey C AU - Resnicow, Ken AD - National Cancer Institute, Bethesda, MD, USA shaikhab@mail.nih.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 492 EP - 501 PB - Sage Publications, Thousand Oaks CA VL - 38 IS - 5 SN - 1090-1981, 1090-1981 KW - African Americans fruit and vegetable consumption mediation analysis interaction effects latent variable structural equation modeling KW - Healthy food KW - Telephone services KW - Motivation KW - Interventions KW - Christian churches KW - Moderators KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/927830337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education+%26+Behavior&rft.atitle=Direct+and+Mediated+Effects+of+Two+Theoretically+Based+Interventions+to+Increase+Consumption+of+Fruits+and+Vegetables+in+the+Healthy+Body+Healthy+Spirit+Trial&rft.au=Shaikh%2C+Abdul+R%3BVinokur%2C+Amiram+D%3BYaroch%2C+Amy+L%3BWilliams%2C+Geoffrey+C%3BResnicow%2C+Ken&rft.aulast=Shaikh&rft.aufirst=Abdul&rft.date=2011-10-01&rft.volume=38&rft.issue=5&rft.spage=492&rft.isbn=&rft.btitle=&rft.title=Health+Education+%26+Behavior&rft.issn=10901981&rft_id=info:doi/10.1177%2F1090198110384468 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-11-02 N1 - Number of references - 43 N1 - Last updated - 2016-09-27 N1 - CODEN - HEDBFS N1 - SubjectsTermNotLitGenreText - Healthy food; Interventions; Motivation; Telephone services; Moderators; Christian churches DO - http://dx.doi.org/10.1177/1090198110384468 ER - TY - JOUR T1 - Internal standard-based analysis of microarray data2-Analysis of functional associations between HVE-genes AN - 918063150; 16141752 AB - In this work we apply the Internal Standard-based analytical approach that we described in an earlier communication and here we demonstrate experimental results on functional associations among the hypervariably-expressed genes (HVE-genes). Our working assumption was that those genetic components, which initiate the disease, involve HVE-genes for which the level of expression is undistinguishable among healthy individuals and individuals with pathology. We show that analysis of the functional associations of the HVE-genes is indeed suitable to revealing disease-specific differences. We show also that another possible exploit of HVE-genes for characterization of pathological alterations is by using multivariate classification methods. This in turn offers important clues on naturally occurring dynamic processes in the organism and is further used for dynamic discrimination of groups of compared samples. We conclude that our approach can uncover principally new collective differences that cannot be discerned by individual gene analysis. JF - Nucleic Acids Research AU - Dozmorov, Igor M AU - Jarvis, James AU - Saban, Ricardo AU - Benbrook, Doris M AU - Wakeland, Edward AU - Aksentijevich, Ivona AU - Ryan, John AU - Chiorazzi, Nicholas AU - Guthridge, Joel M AU - Drewe, Elizabeth AU - Tighe, Patrick J AU - Centola, Michael AU - Lefkovits, Ivan AD - super(1)Oklahoma Medical Research Foundation, super(2)Oklahoma University Health Science Center HSC, Oklahoma City, OK 73104, super(3)The University of Texas Southwestern Medical Center, Dallas, Texas 75390, super(4)National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, super(5)The Feinstein Institute for Medical Research, super(6)The Departments of Medicine and of Cell Biology, North Shore University Hospital, super(7)Albert Einstein College of Medicine, Manhasset, NY, USA, super(8)University of Nottingham, Nottingham, UK and super(9)Department of Biomedicine, University Clinics Basel, Vesalianum, Vesalgasse 1, CH-4051 Basel, Switzerland, igor-dozmorov@omrf.org Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 7881 EP - 7899 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 39 IS - 18 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Classification KW - Communication KW - G 07880:Human Genetics KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918063150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Internal+standard-based+analysis+of+microarray+data2-Analysis+of+functional+associations+between+HVE-genes&rft.au=Dozmorov%2C+Igor+M%3BJarvis%2C+James%3BSaban%2C+Ricardo%3BBenbrook%2C+Doris+M%3BWakeland%2C+Edward%3BAksentijevich%2C+Ivona%3BRyan%2C+John%3BChiorazzi%2C+Nicholas%3BGuthridge%2C+Joel+M%3BDrewe%2C+Elizabeth%3BTighe%2C+Patrick+J%3BCentola%2C+Michael%3BLefkovits%2C+Ivan&rft.aulast=Dozmorov&rft.aufirst=Igor&rft.date=2011-10-01&rft.volume=39&rft.issue=18&rft.spage=7881&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkr503 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2013-04-05 N1 - SubjectsTermNotLitGenreText - Classification; Communication DO - http://dx.doi.org/10.1093/nar/gkr503 ER - TY - JOUR T1 - Use of Surveillance, Epidemiology, and End Results-Medicare Data to Conduct Case-Control Studies of Cancer Among the US Elderly AN - 918052167; 16099534 AB - Cancer is an important cause of morbidity in the elderly, and many medical conditions and treatments influence cancer risk. The Surveillance, Epidemiology, and End Results (SEER)-Medicare database can be used to conduct population-based case-control studies that elucidate the etiology of cancer among the US elderly. SEER-Medicare links data on malignancies ascertained through SEER cancer registries to claims from Medicare, the US government insurance program for people over age 65 years. Under one approach described herein, elderly cancer cases are ascertained from SEER data (1987-2005). Matched controls are selected from a 5% random sample of Medicare beneficiaries. Risk factors of interest, including medical conditions and procedures, are identified by using linked Medicare claims. Strengths of this design include the ready availability of data, representative sampling from the US elderly population, and large sample size (e.g., under one scenario: 1,176,950 cases, including 221,389 prostate cancers, 185,853 lung cancers, 138,041 breast cancers, and 124,442 colorectal cancers; and 100,000 control subjects). Limitations reflect challenges in exposure assessment related to Medicare claims: restricted range of evaluable risk factors, short time before diagnosis/selection for ascertainment, and inaccuracies in claims. With awareness of limitations, investigators have in SEER-Medicare data a valuable resource for epidemiologic research on cancer etiology. JF - American Journal of Epidemiology AU - Engels, Eric A AU - Pfeiffer, Ruth M AU - Ricker, Winnie AU - Wheeler, William AU - Parsons, Ruth AU - Warren, Joan L Y1 - 2011/10/01/ PY - 2011 DA - 2011 Oct 01 SP - 860 EP - 870 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 174 IS - 7 SN - 0002-9262, 0002-9262 KW - Health & Safety Science Abstracts; Risk Abstracts KW - USA KW - Etiology KW - Epidemiology KW - colorectal carcinoma KW - Risk factors KW - Elderly KW - Breast cancer KW - elderly KW - prostate cancer KW - Morbidity KW - Lung cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918052167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Use+of+Surveillance%2C+Epidemiology%2C+and+End+Results-Medicare+Data+to+Conduct+Case-Control+Studies+of+Cancer+Among+the+US+Elderly&rft.au=Engels%2C+Eric+A%3BPfeiffer%2C+Ruth+M%3BRicker%2C+Winnie%3BWheeler%2C+William%3BParsons%2C+Ruth%3BWarren%2C+Joan+L&rft.aulast=Engels&rft.aufirst=Eric&rft.date=2011-10-01&rft.volume=174&rft.issue=7&rft.spage=860&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwr146 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - Etiology; Epidemiology; colorectal carcinoma; Risk factors; Elderly; Breast cancer; prostate cancer; elderly; Morbidity; Lung cancer; USA DO - http://dx.doi.org/10.1093/aje/kwr146 ER - TY - JOUR T1 - RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors. AN - 916852880; 21834757 AB - In an effort to develop strategies that improve the efficacy of existing anticancer agents, we have conducted a siRNA-based RNAi screen to identify genes that, when targeted by siRNA, improve the activity of the topoisomerase I (Top1) poison camptothecin (CPT). Screening was conducted using a set of siRNAs corresponding to over 400 apoptosisrelated genes in MDA-MB-231 breast cancer cells. During the course of these studies, we identified the silencing of MAP3K7 as a significant enhancer of CPT activity. Follow-up analysis of caspase activity and caspase-dependent phosphorylation of histone H2AX demonstrated that the silencing of MAP3K7 enhanced CPT-associated apoptosis. Silencing MAP3K7 also sensitized cells to additional compounds, including CPT clinical analogs. This activity was not restricted to MDA-MB-231 cells, as the silencing of MAP3K7 also sensitized the breast cancer cell line MDA-MB-468 and HCT-116 colon cancer cells. However, MAP3K7 silencing did not affect compound activity in the comparatively normal mammary epithelial cell line MCF10A, as well as some additional tumorigenic lines. MAP3K7 encodes the TAK1 kinase, an enzyme that is central to the regulation of many processes associated with the growth of cancer cells (e.g. NF- κB, JNK, and p38 signaling). An analysis of TAK1 signaling pathway members revealed that the silencing of TAB2 also sensitizes MDA-MB-231 and HCT-116 cells towards CPT. These findings may offer avenues towards lowering the effective doses of Top1 inhibitors in cancer cells and, in doing so, broaden their application. JF - Current cancer drug targets AU - Martin, S E AU - Wu, Z-H AU - Gehlhaus, K AU - Jones, T L AU - Zhang, Y-W AU - Guha, R AU - Miyamoto, S AU - Pommier, Y AU - Caplen, N J AD - Gene Silencing Section, Genetics Branch, CCR, NCI, NIH, Bethesda, MD 20892, USA. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 976 EP - 986 VL - 11 IS - 8 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - Neoplasm Proteins KW - RNA, Small Interfering KW - TAB2 protein, human KW - Topoisomerase Inhibitors KW - MAP Kinase Kinase Kinases KW - EC 2.7.11.25 KW - MAP kinase kinase kinase 7 KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - Adaptor Proteins, Signal Transducing -- metabolism KW - MAP Kinase Signaling System KW - Gene Transfer Techniques KW - Camptothecin -- pharmacology KW - Humans KW - Apoptosis -- drug effects KW - Adaptor Proteins, Signal Transducing -- genetics KW - Genetic Therapy KW - Cell Line, Tumor KW - Adaptor Proteins, Signal Transducing -- antagonists & inhibitors KW - Female KW - Breast Neoplasms -- drug therapy KW - Neoplasm Proteins -- antagonists & inhibitors KW - MAP Kinase Kinase Kinases -- genetics KW - Breast Neoplasms -- metabolism KW - Breast Neoplasms -- therapy KW - Drug Resistance, Neoplasm KW - Topoisomerase Inhibitors -- pharmacology KW - MAP Kinase Kinase Kinases -- metabolism KW - MAP Kinase Kinase Kinases -- antagonists & inhibitors KW - Colonic Neoplasms -- therapy KW - Colonic Neoplasms -- drug therapy KW - Neoplasm Proteins -- genetics KW - Colonic Neoplasms -- metabolism KW - RNA Interference KW - Neoplasm Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/916852880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+cancer+drug+targets&rft.atitle=RNAi+screening+identifies+TAK1+as+a+potential+target+for+the+enhanced+efficacy+of+topoisomerase+inhibitors.&rft.au=Martin%2C+S+E%3BWu%2C+Z-H%3BGehlhaus%2C+K%3BJones%2C+T+L%3BZhang%2C+Y-W%3BGuha%2C+R%3BMiyamoto%2C+S%3BPommier%2C+Y%3BCaplen%2C+N+J&rft.aulast=Martin&rft.aufirst=S&rft.date=2011-10-01&rft.volume=11&rft.issue=8&rft.spage=976&rft.isbn=&rft.btitle=&rft.title=Current+cancer+drug+targets&rft.issn=1873-5576&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-09 N1 - Date created - 2012-01-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cancer Ther. 2006 Dec;5(12):2970-6 [17172402] Curr Med Chem. 2006;13(29):3483-92 [17168718] Nature. 2007 Apr 12;446(7137):815-9 [17429401] Oncogene. 2007 May 14;26(22):3214-26 [17496917] Cancer Cell. 2007 Jun;11(6):498-512 [17560332] Biochim Biophys Acta. 2007 Aug;1773(8):1358-75 [17481747] Annu Rev Genomics Hum Genet. 2007;8:81-108 [17477824] Cancer Chemother Pharmacol. 2008 Jan;61(1):125-31 [17426973] Expert Opin Ther Targets. 2007 Oct;11(10):1339-53 [17907963] Cancer Cell. 2008 Feb;13(2):91-104 [18242510] Oncogene. 2008 Feb 21;27(9):1198-207 [17828308] Cancer Res. 2008 Mar 1;68(5):1462-70 [18316610] J Biomol Screen. 2008 Feb;13(2):142-8 [18216392] Biochem Pharmacol. 2008 Mar 15;75(6):1262-71 [18061144] EMBO J. 2008 May 7;27(9):1368-77 [18388863] Mol Cancer. 2008;7:66 [18694480] DNA Repair (Amst). 2008 Dec 1;7(12):2010-9 [18832051] Nat Rev Cancer. 2008 Dec;8(12):957-67 [19005492] Mol Cell Biol. 2009 Jan;29(1):68-82 [18955500] Oncogene. 2009 Jun 11;28(23):2257-65 [19421137] J Biol Chem. 2009 Jul 3;284(27):18085-95 [19416980] J Transl Med. 2009;7:43 [19519883] Mol Cell Biol. 2009 Oct;29(20):5529-39 [19687304] J Biol Chem. 2010 Mar 12;285(11):8122-9 [20061393] Int J Biochem Cell Biol. 2010 May;42(5):585-9 [20060931] Cancer Res. 2010 Jun 1;70(11):4318-26 [20460535] Gynecol Oncol. 2010 Sep;118(3):220-7 [20722101] Mol Cell. 2010 Oct 8;40(1):63-74 [20932475] Mol Cell. 2010 Oct 8;40(1):75-86 [20932476] Sci Signal. 2011;4(156):pe2 [21245467] Clin Cancer Res. 2011 May 1;17(9):2744-56 [21385921] Mol Cell Biol. 2011 Jul;31(14):2774-86 [21606198] Mol Cancer Res. 2011 Aug;9(8):1042-53 [21700681] Cancer Res. 2011 Sep 1;71(17):5806-17 [21775522] Cancer Res. 1999 Dec 1;59(23):5938-46 [10606239] J Biol Chem. 2000 Mar 31;275(13):9390-5 [10734083] J Biol Chem. 2000 Mar 31;275(13):9501-9 [10734098] Cancer Res. 2002 Mar 15;62(6):1688-95 [11912141] Nat Rev Drug Discov. 2002 Jul;1(7):493-502 [12120256] Crit Rev Oncol Hematol. 2003 Jan;45(1):91-108 [12482574] J Biol Chem. 2003 May 16;278(20):18485-90 [12624112] J Biol Chem. 2003 May 30;278(22):20303-12 [12660252] Oncogene. 2003 Oct 20;22(47):7340-58 [14576842] Cancer Res. 2004 Mar 15;64(6):2096-104 [15026349] Cancer Res. 1989 Sep 15;49(18):5077-82 [2548710] Cancer Res. 1989 Nov 15;49(22):6365-8 [2553254] Cancer Res. 1990 Sep 15;50(18):6075-86 [1975513] Int J Cancer. 1999 Jul 30;82(3):396-404 [10399957] Nat Cell Biol. 2005 Jun;7(6):591-600 [15864305] Mol Cancer Ther. 2005 Jun;4(6):885-900 [15956246] J Biol Chem. 2005 Jul 29;280(30):27728-41 [15837794] Cancer Lett. 2006 Jan 8;231(1):74-86 [16356833] Science. 2006 Feb 24;311(5764):1141-6 [16497931] Nat Rev Cancer. 2006 Oct;6(10):789-802 [16990856] FASEB J. 2006 Oct;20(12):1982-91 [17012250] Oncogene. 2006 Oct 30;25(51):6800-16 [17072329] Nat Chem Biol. 2006 Dec;2(12):689-700 [17108987] Mol Cell Biol. 2006 Dec;26(24):9377-86 [17000754] Lancet Oncol. 2007 Mar;8(3):235-44 [17329194] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - coMOTIF: a mixture framework for identifying transcription factor and a coregulator motif in ChIP-seq Data AN - 915483511; 16101704 AB - Motivation: ChIP-seq data are enriched in binding sites for the protein immunoprecipitated. Some sequences may also contain binding sites for a coregulator. Biologists are interested in knowing which coregulatory factor motifs may be present in the sequences bound by the protein ChIP'ed.Results: We present a finite mixture framework with an expectation-maximization algorithm that considers two motifs jointly and simultaneously determines which sequences contain both motifs, either one or neither of them. Tested on 10 simulated ChIP-seq datasets, our method performed better than repeated application of MEME in predicting sequences containing both motifs. When applied to a mouse liver Foxa2 ChIP-seq dataset involving ~ 12 000 400-bp sequences, coMOTIF identified co-occurrence of Foxa2 with Hnf4a, Cebpa, E-box, Ap1/Maf or Sp1 motifs in ~6-33% of these sequences. These motifs are either known as liver-specific transcription factors or have an important role in liver function. JF - Bioinformatics AU - Xu, Mengyuan AU - Weinberg, Clarice R AU - Umbach, David M AU - Li, Leping AD - Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA, Y1 - 2011/10/01/ PY - 2011 DA - 2011 Oct 01 SP - 2625 EP - 2632 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 27 IS - 19 SN - 1367-4803, 1367-4803 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Sp1 protein KW - Computer programs KW - software KW - Data processing KW - Transcription factors KW - Hepatocyte nuclear factor 4 KW - Activator protein 1 KW - Liver KW - Algorithms KW - Bioinformatics KW - Internet KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/915483511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=coMOTIF%3A+a+mixture+framework+for+identifying+transcription+factor+and+a+coregulator+motif+in+ChIP-seq+Data&rft.au=Xu%2C+Mengyuan%3BWeinberg%2C+Clarice+R%3BUmbach%2C+David+M%3BLi%2C+Leping&rft.aulast=Xu&rft.aufirst=Mengyuan&rft.date=2011-10-01&rft.volume=27&rft.issue=19&rft.spage=2625&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtr397 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Computer programs; Sp1 protein; software; Data processing; Transcription factors; Activator protein 1; Hepatocyte nuclear factor 4; Algorithms; Liver; Bioinformatics; Internet DO - http://dx.doi.org/10.1093/bioinformatics/btr397 ER - TY - JOUR T1 - Care Management in Japanese Acute Psychiatric Units: A National Study AN - 914790850; 201200810 AB - Objectives: Japan has the largest number of psychiatric beds per capita in the world. Both reducing the number of beds and preventing long-term hospitalization of individuals with mental illness is essential. This study surveys Japanese acute psychiatric units to investigate the process by which care management is provided. Care management is important to prevent those with a higher need for care from becoming long-term inpatients. Methods: All of the psychiatric emergency units (PEUs) and acute psychiatric treatment units (PAUs) in Japan (N = 234) were surveyed. Chief nurses of each unit completed items from a questionnaire that assessed basic characteristics of the unit and the implementation of each element of care management (i.e., triage, assessment, care conferences, and care plan development). Additionally, the association between care management and the clinical outcomes of the unit is examined. Results: The length of stay is 52.0 days for PEUs and 65.2 days for PAUs, and more than 25 percent of patients transferred to another unit or hospital, instead of being discharged PEUs report slightly higher rates of offering each element of care management compared to PAUs. However, the overall rates are still inadequate, especially for the initial triage/screening and care plan development. The frequency of care conferences varies widely across units. While nurses and psychiatric social workers tend to participate fully, patient families and community service providers are not always included in case conferences. Care plans are developed in 58 percent of units. Only 20 percent of units had some kind of care management tool. Units implementing care management have more patients discharged to the community and have a trend for shorter lengths of stay, which suggests that care management is related to better clinical outcomes. Conclusion: The overall rates of care management in acute psychiatric units in Japan are inadequate. Dissemination of care management is, therefore, needed. Adapted from the source document. JF - International Journal of Mental Health AU - Setoya, Yutaro AU - Sato, Sayaka AU - Satake, Naoko AU - Ito, Junichiro AD - National Institute of Mental Health, National Center of Neurology and Psychiatry, Japan Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 41 EP - 54 PB - M.E. Sharpe, Armonk NY VL - 40 IS - 3 SN - 0020-7411, 0020-7411 KW - Care management KW - Discharged KW - Length of stay KW - Psychiatric units KW - Japan KW - Care plans KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/914790850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Mental+Health&rft.atitle=Care+Management+in+Japanese+Acute+Psychiatric+Units%3A+A+National+Study&rft.au=Setoya%2C+Yutaro%3BSato%2C+Sayaka%3BSatake%2C+Naoko%3BIto%2C+Junichiro&rft.aulast=Setoya&rft.aufirst=Yutaro&rft.date=2011-10-01&rft.volume=40&rft.issue=3&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Mental+Health&rft.issn=00207411&rft_id=info:doi/10.2753%2FIMH0020-7411400303 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-01-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Care management; Japan; Psychiatric units; Care plans; Length of stay; Discharged DO - http://dx.doi.org/10.2753/IMH0020-7411400303 ER - TY - JOUR T1 - Challenges and Solutions for Latin American-Trained International Medical Graduates in Psychiatry Residency AN - 914790614; 201200361 AB - Objective: Latin American-trained international medical graduates (IMGs) in psychiatry residency face multiple challenges that go beyond their medical training. These challenges call for innovative problem-solving. Although the professional development of IMGs has been discussed in the professional literature, little is written about their experiences. In this report, a group of IMGs reflect on their experiences and describe how they solved challenges. Method: Using cogenerative ethnography, four IMGs trained in Colombia, the Dominican Republic, and Mexico provided insights on their challenges and solutions while adapting to psychiatric residency training. Individual interviews, focused discussion, and written reports were analyzed using data reduction, data display, and conclusion-drawing techniques. Results: We illustrate the challenges of IMG training in psychiatry using their reflections and stories. We categorize these challenges into three domains: immigration and acculturation, social adjustment, and medical training. Quotes were selected to illustrate IMGs' challenges and coping strategies. Conclusion: Some of the combined cultural, social, and academic challenges of Latin American-trained IMGs in psychiatry residency are described. Recognizing and planning for the personal challenges of IMGs in psychiatry can enhance the transition into psychiatric training. Ultimately, improvements in IMG training converts into improved healthcare for all patients. Adapted from the source document. JF - International Journal of Mental Health AU - Hausmann-Stabile, Carolina AU - Zayas, Luis H AU - Hauser, David AU - Carvajal, Carlos AU - Mejia, Carlina AU - Nieves, Delia AD - National Institute of Mental Health predoctoral fellow at Washington University in St. Louis Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 29 EP - 40 PB - M.E. Sharpe, Armonk NY VL - 40 IS - 3 SN - 0020-7411, 0020-7411 KW - Coping strategies KW - Professional development KW - Foreign doctors KW - Mexico KW - Medical education KW - Psychiatry KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/914790614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Mental+Health&rft.atitle=Challenges+and+Solutions+for+Latin+American-Trained+International+Medical+Graduates+in+Psychiatry+Residency&rft.au=Hausmann-Stabile%2C+Carolina%3BZayas%2C+Luis+H%3BHauser%2C+David%3BCarvajal%2C+Carlos%3BMejia%2C+Carlina%3BNieves%2C+Delia&rft.aulast=Hausmann-Stabile&rft.aufirst=Carolina&rft.date=2011-10-01&rft.volume=40&rft.issue=3&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Mental+Health&rft.issn=00207411&rft_id=info:doi/10.2753%2FIMH0020-7411400302 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-01-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Psychiatry; Medical education; Foreign doctors; Mexico; Professional development; Coping strategies DO - http://dx.doi.org/10.2753/IMH0020-7411400302 ER - TY - JOUR T1 - Optimization of coronary whole-heart MRA free-breathing technique at 3 Tesla AN - 907177065; 15721079 AB - Four different techniques for 3-T whole-heart coronary magnetic resonance angiography (MRA) using free-breathing three-dimensional segmented parallel imaging and adiabatic T2-preparation were assessed. Coronary MRA at 3 T is improved by shortening the acquisition window more than employing the highest spatial resolution. Double-oblique whole-heart acquisitions result in better overall image quality and allow for better delineation of the left anterior descending coronary artery. It is possible to attain shorter acquisition windows and a smaller voxel size at 3 T than previously reported at 1.5 T. JF - Magnetic Resonance Imaging AU - Gharib, Ahmed M AU - Abd-Elmoniem, Khaled Z AU - Herzka, Daniel A AU - Ho, Vincent B AU - Locklin, Julie AU - Tzatha, Efstathia AU - Stuber, Matthias AU - Pettigrew, Roderic I Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1125 EP - 1130 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 29 IS - 8 SN - 0730-725X, 0730-725X KW - Biotechnology and Bioengineering Abstracts KW - Adiabatic KW - Angiography KW - Magnetic resonance imaging KW - N.M.R. KW - coronary artery KW - spatial discrimination KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907177065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=Optimization+of+coronary+whole-heart+MRA+free-breathing+technique+at+3+Tesla&rft.au=Gharib%2C+Ahmed+M%3BAbd-Elmoniem%2C+Khaled+Z%3BHerzka%2C+Daniel+A%3BHo%2C+Vincent+B%3BLocklin%2C+Julie%3BTzatha%2C+Efstathia%3BStuber%2C+Matthias%3BPettigrew%2C+Roderic+I&rft.aulast=Gharib&rft.aufirst=Ahmed&rft.date=2011-10-01&rft.volume=29&rft.issue=8&rft.spage=1125&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2011.07.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-12-03 N1 - SubjectsTermNotLitGenreText - Angiography; Adiabatic; Magnetic resonance imaging; spatial discrimination; N.M.R.; coronary artery DO - http://dx.doi.org/10.1016/j.mri.2011.07.008 ER - TY - JOUR T1 - Imaging tumor endothelial marker 8 using an super(18)F-labeled peptide AN - 907174034; 15690241 AB - Purpose: Tumor endothelial marker 8 (TEM8) has been reported to be upregulated in both tumor cells and tumor-associated endothelial cells in several cancer types. TEM8 antagonists and TEM8-targeted delivery of toxins have been developed as effective cancer therapeutics. The ability to image TEM8 expression would be of use in evaluating TEM8-targeted cancer therapy. Methods: A 13-meric peptide, KYNDRLPLYISNP (QQM), identified from the small loop in domain IV of protective antigen of anthrax toxin was evaluated for TEM8 binding and labeled with super(18)F for small-animal PET imaging in both UM-SCC1 head-and-neck cancer and MDA-MB-435 melanoma models. Results: A modified ELISA showed that QQM peptide bound specifically to the extracellular vWA domain of TEM8 with an IC sub(50) value of 304 nM. Coupling 4-nitrophenyl 2- super(18)F-fluoropropionate with QQM gave almost quantitative yield and a high specific activity (79.2+/-7.4 TBq/mmol, n=5) of super(18)F-FP-QQM at the end of synthesis. super(18)F-FP-QQM showed predominantly renal clearance and had significantly higher accumulation in TEM8 high-expressing UM-SCC1 tumors (2.96+/-0.84 %ID/g at 1 h after injection) than TEM8 low-expressing MDA-MB-435 tumors (1.38+/-0.56 %ID/g at 1 h after injection). Conclusion: QQM peptide bound specifically to the extracellular domain of TEM8. super(18)F-FP-QQM peptide tracer would be a promising lead compound for measuring TEM8 expression. Further efforts to improve the affinity and specificity of the tracer and to increase its metabolic stability are warranted. JF - European Journal of Nuclear Medicine and Molecular Imaging AU - Quan, Qimeng AU - Yang, Min AU - Gao, Haokao AU - Zhu, Lei AU - Lin, Xin AU - Guo, Ning AU - Zhang, Guixiang AU - Eden, Henry S AU - Niu, Gang AU - Chen, Xiaoyuan AD - Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 9 Memorial Drive, 9/1 W111, Bethesda, MD, 20892, USA Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1806 EP - 1815 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 38 IS - 10 SN - 1619-7070, 1619-7070 KW - Biotechnology and Bioengineering Abstracts KW - Enzyme-linked immunosorbent assay KW - protective antigen KW - Tumors KW - Tumor cells KW - Antagonists KW - Toxins KW - Cancer KW - Melanoma KW - Endothelial cells KW - Tracers KW - Kidney KW - Anthrax KW - Nuclear medicine KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907174034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.atitle=Imaging+tumor+endothelial+marker+8+using+an+super%2818%29F-labeled+peptide&rft.au=Quan%2C+Qimeng%3BYang%2C+Min%3BGao%2C+Haokao%3BZhu%2C+Lei%3BLin%2C+Xin%3BGuo%2C+Ning%3BZhang%2C+Guixiang%3BEden%2C+Henry+S%3BNiu%2C+Gang%3BChen%2C+Xiaoyuan&rft.aulast=Quan&rft.aufirst=Qimeng&rft.date=2011-10-01&rft.volume=38&rft.issue=10&rft.spage=1806&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.issn=16197070&rft_id=info:doi/10.1007%2Fs00259-011-1871-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; protective antigen; Tumors; Tumor cells; Cancer; Toxins; Antagonists; Melanoma; Endothelial cells; Tracers; Kidney; Nuclear medicine; Anthrax DO - http://dx.doi.org/10.1007/s00259-011-1871-4 ER - TY - JOUR T1 - The novel delta opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions AN - 904486906; 15165844 AB - We previously reported that the delta opioid receptor (DOP) agonists SNC80 and TAN-67 produce potent antidepressant-like and antinociceptive effects in rodents. However, SNC80 produced convulsive effects. Recently, we succeeded in synthesizing a novel DOP agonist called KNT-127. The present study examined the convulsive, antidepressant-like, and antinociceptive effects of KNT-127 in mice. In contrast to SNC80, KNT-127 produced no convulsions at doses of up to 100mg/kg. In mice subjected to the forced swim test, a screening model for antidepressants, KNT-127 (1mg/kg, s.c.) significantly decreased the duration of immobility and increased the duration of swimming without influencing spontaneous locomotor activity. These behavioral changes were similar to that observed for the tricyclic antidepressant imipramine (6mg/kg). The antidepressant-like effect of KNT-127 in mice was antagonized by pretreatment with naltrindole (NTI), a selective DOP antagonist, or naltriben, a putative DOP2 subtype antagonist. In addition, KNT-127 (3mg/kg, s.c.) significantly reduced the number of acetic acid-induced abdominal constrictions and the duration of licking time, respectively, in mice subjected to a writhing test and a formalin test. These antinociceptive effects were antagonized by pretreatment with either NTI or 7-benzylidenenaltrexone, a putative DOP1 subtype antagonist. We propose that KNT-127 should be considered as a candidate compound for the development of DOP-based antidepressants and/or analgesics that lack convulsive effects. JF - Behavioural Brain Research AU - Saitoh, Akiyoshi AU - Sugiyama, Azusa AU - Nemoto, Toru AU - Fujii, Hideaki AU - Wada, Keiji AU - Oka, Jun-Ichiro AU - Nagase, Hiroshi AU - Yamada, Mitsuhiko AD - Department of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo 187-8553, Japan, asaitoh@ncnp.go.jp Y1 - 2011/10/01/ PY - 2011 DA - 2011 Oct 01 SP - 271 EP - 279 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 223 IS - 2 SN - 0166-4328, 0166-4328 KW - Biotechnology and Bioengineering Abstracts; Animal Behavior Abstracts; CSA Neurosciences Abstracts KW - Antidepressants KW - Swimming KW - Naltrindole KW - Opioid receptors (type delta) KW - imipramine KW - Convulsions KW - Locomotor activity KW - Pain perception KW - Tricyclic antidepressants KW - Analgesics KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25080:Orientation, Migration and Locomotion KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904486906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+Brain+Research&rft.atitle=The+novel+delta+opioid+receptor+agonist+KNT-127+produces+antidepressant-like+and+antinociceptive+effects+in+mice+without+producing+convulsions&rft.au=Saitoh%2C+Akiyoshi%3BSugiyama%2C+Azusa%3BNemoto%2C+Toru%3BFujii%2C+Hideaki%3BWada%2C+Keiji%3BOka%2C+Jun-Ichiro%3BNagase%2C+Hiroshi%3BYamada%2C+Mitsuhiko&rft.aulast=Saitoh&rft.aufirst=Akiyoshi&rft.date=2011-10-01&rft.volume=223&rft.issue=2&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Behavioural+Brain+Research&rft.issn=01664328&rft_id=info:doi/10.1016%2Fj.bbr.2011.04.041 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Antidepressants; Swimming; Naltrindole; imipramine; Opioid receptors (type delta); Locomotor activity; Convulsions; Tricyclic antidepressants; Pain perception; Analgesics DO - http://dx.doi.org/10.1016/j.bbr.2011.04.041 ER - TY - JOUR T1 - Multisite Carcinogenicity and Respiratory Toxicity of Inhaled 1-Bromopropane in Rats and Mice AN - 902362536; 15807372 AB - Two-year 1-bromopropane (1-BP) inhalation studies were conducted because of the potential for widespread exposure, the lack of chronic toxicity and carcinogenicity data, and the known carcinogenicity of structurally related compounds. Male and female F344/N rats and B6C3F1/N mice were exposed by inhalation to 0, 62.5 (mice only), 125, 250, or 500 (rats only) ppm 1-BP for 6 hr/day, 5 days/week for 105 weeks. Exposure of male and female rats to 1-BP resulted in significantly increased incidences of adenomas of the large intestine and skin neoplasms. In male rats, the incidence of malignant mesothelioma of the epididymis was statistically significantly increased at 500 ppm, but the biological significance of this common lesion is unclear. Incidences of pancreatic islet adenoma in male rats were significantly increased at all concentrations relative to concurrent controls but were within the historical control range for inhalation studies. There was no evidence of carcinogenic activity of 1-BP in male B6C3F1 mice; however, significantly increased incidences of alveolar/bronchiolar neoplasms of the lung were present in female mice. Exposure to 1-BP also resulted in increased incidences of nonneoplastic lesions in the nose of rats and mice, the larynx of rats and male mice, the trachea of female rats and male and female mice, and the lungs of mice. Inflammatory lesions with Splendore Hoeppli (S-H) material were present primarily in the nose and skin of exposed male and female rats, indicating that 1-BP caused immunosuppression. JF - Toxicologic Pathology AU - Morgan, Daniel L AU - Nyska, Abraham AU - Harbo, Sam Jens AU - Grumbein, Sondra L AU - Dill, Jeffrey A AU - Roycroft, Joseph H AU - Kissling, Grace E AU - Cesta, Mark F AD - National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina, USA  , morgan3@niehs.nih.gov morgan3@niehs.nih.gov morgan3@niehs.nih.gov morgan3@niehs.nih.gov morgan3@niehs.nih.gov morgan3@niehs.nih.gov morgan3@niehs.nih.gov Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 938 EP - 948 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 39 IS - 6 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Inhalation KW - Skin KW - Data processing KW - Epididymis KW - Pancreas KW - Large intestine KW - Islets of Langerhans KW - Toxicity KW - Alveoli KW - Inflammation KW - Lung KW - Carcinogenicity KW - Chronic toxicity KW - Larynx KW - mesothelioma KW - Nose KW - Trachea KW - Adenoma KW - Immunosuppression KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902362536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Multisite+Carcinogenicity+and+Respiratory+Toxicity+of+Inhaled+1-Bromopropane+in+Rats+and+Mice&rft.au=Morgan%2C+Daniel+L%3BNyska%2C+Abraham%3BHarbo%2C+Sam+Jens%3BGrumbein%2C+Sondra+L%3BDill%2C+Jeffrey+A%3BRoycroft%2C+Joseph+H%3BKissling%2C+Grace+E%3BCesta%2C+Mark+F&rft.aulast=Morgan&rft.aufirst=Daniel&rft.date=2011-10-01&rft.volume=39&rft.issue=6&rft.spage=938&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623311416374 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Inhalation; Data processing; Skin; Epididymis; Pancreas; Islets of Langerhans; Large intestine; Toxicity; Alveoli; Inflammation; Carcinogenicity; Lung; Chronic toxicity; Larynx; mesothelioma; Nose; Adenoma; Trachea; Immunosuppression DO - http://dx.doi.org/10.1177/0192623311416374 ER - TY - JOUR T1 - ERD-Based Online Brain-Machine Interfaces (BMI) in the Context of Neurorehabilitation: Optimizing BMI Learning and Performance AN - 902350666; 15840810 AB - Event-related desynchronization (ERD) of sensori-motor rhythms (SMR) can be used for online brain-machine interface (BMI) control, but yields challenges related to the stability of ERD and feedback strategy to optimize BMI learning. Here, we compared two approaches to this challenge in 20 right-handed healthy subjects (HS, five sessions each, S1-S5) and four stroke patients (SP, 15 sessions each, S1-S15). ERD was recorded from a 275-sensor MEG system. During daily training, motor imagery-induced ERD led to visual and proprioceptive feedback delivered through an orthotic device attached to the subjects' hand and fingers. Group A trained with a heterogeneous reference value (RV) for ERD detection with binary feedback and Group B with a homogenous RV and graded feedback (10 HS and 2 SP in each group). HS in Group B showed better BMI performance than Group A ( p < 0.001 ) and improved BMI control from S1 to S5 ( p = 0.012 ) while Group A did not. In spite of the small n, SP in Group B showed a trend for a higher BMI performance ( p = 0.06 ) and learning was significantly better ( p < 0.05 ) . Using a homogeneous RV and graded feedback led to improved modulation of ipsilesional activity resulting in superior BMI learning relative to use of a heterogeneous RV and binary feedback. JF - IEEE Transactions on Neural Systems and Rehabilitation Engineering AU - Soekadar, Surjo R AU - Witkowski, Matthias AU - Mellinger, Juergen AU - Ramos, Ander AU - Birbaumer, Niels AU - Cohen, Leonardo G AD - Human Cortical Physiology and Stroke Neurorehabilitation Section, HCPS, NINDS, NIH, Bethesda, MD, USA Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 542 EP - 549 PB - Institute of Electrical and Electronics Engineers, Inc., 3 Park Avenue, 17th Fl New York NY 10016-5997 United States VL - 19 IS - 5 SN - 1534-4320, 1534-4320 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Magnetoencephalography KW - Handedness KW - Learning KW - Rehabilitation KW - Synchronization KW - Stroke KW - Hand KW - Sensorimotor integration KW - Substance P KW - Finger KW - Proprioception KW - Rhythms KW - Feedback KW - Internet KW - Neurology KW - N3 11002:Computational & theoretical neuroscience KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902350666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Neural+Systems+and+Rehabilitation+Engineering&rft.atitle=ERD-Based+Online+Brain-Machine+Interfaces+%28BMI%29+in+the+Context+of+Neurorehabilitation%3A+Optimizing+BMI+Learning+and+Performance&rft.au=Soekadar%2C+Surjo+R%3BWitkowski%2C+Matthias%3BMellinger%2C+Juergen%3BRamos%2C+Ander%3BBirbaumer%2C+Niels%3BCohen%2C+Leonardo+G&rft.aulast=Soekadar&rft.aufirst=Surjo&rft.date=2011-10-01&rft.volume=19&rft.issue=5&rft.spage=542&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Neural+Systems+and+Rehabilitation+Engineering&rft.issn=15344320&rft_id=info:doi/10.1109%2FTNSRE.2011.2166809 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Handedness; Magnetoencephalography; Learning; Rehabilitation; Stroke; Synchronization; Hand; Substance P; Sensorimotor integration; Finger; Proprioception; Feedback; Rhythms; Internet; Neurology DO - http://dx.doi.org/10.1109/TNSRE.2011.2166809 ER - TY - JOUR T1 - Detection of Small Bowel Polyps and Ulcers in Wireless Capsule Endoscopy Videos AN - 899162911; 15752823 AB - Over the last decade, wireless capsule endoscopy (WCE) technology has become a very useful tool for diagnosing diseases within the human digestive tract. Physicians using WCE can examine the digestive tract in a minimally invasive way searching for pathological abnormalities such as bleeding, polyps, ulcers, and Crohn's disease. To improve effectiveness of WCE, researchers have developed software methods to automatically detect these diseases at a high rate of success. This paper proposes a novel synergistic methodology for automatically discovering polyps (protrusions) and perforated ulcers in WCE video frames. Finally, results of the methodology are given and statistical comparisons are also presented relevant to other works. JF - IEEE Transactions on Biomedical Engineering AU - Karargyris, Alexandros AU - Bourbakis, Nikolaos AD - National Library of Medicine (NLM) of National Institutes of Health (NIH), Bethesda, USA Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 2777 EP - 2786 PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 United States VL - 58 IS - 10 SN - 0018-9294, 0018-9294 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Crohn's disease KW - software KW - Digestive tract KW - Statistics KW - Ulcers KW - Energy KW - Intestine KW - Bleeding KW - Polyps KW - Endoscopy KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899162911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=IEEE+Transactions+on+Biomedical+Engineering&rft.atitle=Detection+of+Small+Bowel+Polyps+and+Ulcers+in+Wireless+Capsule+Endoscopy+Videos&rft.au=Karargyris%2C+Alexandros%3BBourbakis%2C+Nikolaos&rft.aulast=Karargyris&rft.aufirst=Alexandros&rft.date=2011-10-01&rft.volume=58&rft.issue=10&rft.spage=2777&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Biomedical+Engineering&rft.issn=00189294&rft_id=info:doi/10.1109%2FTBME.2011.2155064 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Crohn's disease; Computer programs; software; Statistics; Digestive tract; Ulcers; Energy; Bleeding; Intestine; Polyps; Endoscopy DO - http://dx.doi.org/10.1109/TBME.2011.2155064 ER - TY - JOUR T1 - A Prospective Analysis of Prolonged Sitting Time and Risk of Renal Cell Carcinoma Among 300,000 Older Adults AN - 899141339; 15796521 AB - Purpose: Accumulating evidence suggests an etiologic role in renal cell carcinoma (RCC) for physical activity. However, it is unknown if prolonged sitting, which is thought to be distinct from too little moderate-vigorous physical activity, is an independent risk factor for RCC. The authors prospectively examined the relationship of prolonged sitting and risk of RCC among 289,512 women and men in the National Institutes of Health-AARP Diet and Health Study. Methods: From 1996 through 2006, 1206 invasive RCC cancer cases were identified. Cox proportional hazards regression was used to estimate multivariate hazard ratios (HR) and 95% confidence intervals. Results: After controlling for known risk factors for RCC, we did not find evidence of associations between RCC risk and time spent per day sitting while watching television or videos (HR sub(7+hrs:1 hr = 0.96 (0.66, 1.38); p trend = 0.707) or total sitting time (HR) sub(9)+hrs: 3hrs = 1.11 (0.87, 1.41); p trend = 0.765). Conclusions: Prolonged sitting time was not associated with RCC risk among men and women in this large cohort. JF - Annals of Epidemiology AU - George, Stephanie M AU - Moore, Steven C AU - Chow, Wong-Ho AU - Schatzkin, Arthur AU - Hollenbeck, Albert R AU - Matthews, Charles E AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, materess@mail.nih.gov Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 787 EP - 790 PB - Elsevier B.V., Box 882 New York NY 10159 United States VL - 21 IS - 10 SN - 1047-2797, 1047-2797 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Diets KW - Risk factors KW - Television KW - physical activity KW - Cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899141339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=A+Prospective+Analysis+of+Prolonged+Sitting+Time+and+Risk+of+Renal+Cell+Carcinoma+Among+300%2C000+Older+Adults&rft.au=George%2C+Stephanie+M%3BMoore%2C+Steven+C%3BChow%2C+Wong-Ho%3BSchatzkin%2C+Arthur%3BHollenbeck%2C+Albert+R%3BMatthews%2C+Charles+E&rft.aulast=George&rft.aufirst=Stephanie&rft.date=2011-10-01&rft.volume=21&rft.issue=10&rft.spage=787&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2011.04.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diets; Risk factors; Television; physical activity; Cancer DO - http://dx.doi.org/10.1016/j.annepidem.2011.04.012 ER - TY - JOUR T1 - Dietary fiber and grain consumption in relation to head and neck cancer in the NIH-AARP Diet and Health Study AN - 899140544; 15759587 AB - Background: Dietary fiber and grain consumption may reduce the risk of head and neck cancer; however, the epidemiological evidence is limited. We investigated this relationship in the National Institutes of Health (NIH)-AARP Diet and Health Study. Methods: Cox proportional hazards models were used to calculate multivariable hazard ratios (HR) and 95% confidence intervals (CI) to investigate dietary fiber and grain intake in relation to head and neck cancer. Results: During approximately 11 years of follow-up, 1,867 (401 women/1,466 men) cases of head and neck cancer were diagnosed. Our data indicated that the relationship between fiber and grain intake and head and neck cancer is modified by sex (p-interactions < 0.001 and 0.001, respectively). Women with higher intake of total fiber and total grains had a lower risk of head and neck cancer (HR sub(10g/day) = 0.77, 95% CI = 0.64-0.93; HR sub(serving/1,000kcal) = 0.89, 95% CI = 0.80-0.99, respectively); this inverse relation was consistent across subtypes of fiber and grains. Conversely in men, the inverse associations were weaker and nonsignificant. Conclusions: In the largest prospective cohort study to investigate this relation to date, intake of total fiber and grain foods was inversely associated with head and neck cancer incidence among women, but not among men. JF - Cancer Causes & Control AU - Lam, Tram Kim AU - Cross, Amanda J AU - Freedman, Neal AU - Park, Yikyung AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Abnet, Christian AD - Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH), Rockville, MD, 20852, USA, lamt@mail.nih.gov lamt@mail.nih.gov lamt@mail.nih.gov lamt@mail.nih.gov lamt@mail.nih.gov lamt@mail.nih.gov Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1405 EP - 1414 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 22 IS - 10 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Diets KW - Fibers KW - risk reduction KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899140544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Dietary+fiber+and+grain+consumption+in+relation+to+head+and+neck+cancer+in+the+NIH-AARP+Diet+and+Health+Study&rft.au=Lam%2C+Tram+Kim%3BCross%2C+Amanda+J%3BFreedman%2C+Neal%3BPark%2C+Yikyung%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur%3BAbnet%2C+Christian&rft.aulast=Lam&rft.aufirst=Tram&rft.date=2011-10-01&rft.volume=22&rft.issue=10&rft.spage=1405&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9813-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diets; risk reduction; Fibers; Cancer DO - http://dx.doi.org/10.1007/s10552-011-9813-9 ER - TY - JOUR T1 - Attitudinal, Behavioral, and Biological Outcomes of a Community Popular Opinion Leader Intervention in China AN - 898919896; 22010808 AB - The effects of a community popular opinion leader (CPOL) intervention were examined among market vendors in a city on the eastern coast of China. Employees of 40 food markets were enrolled in a study that provided HIV-related education and tests, and treatment for sexually transmitted diseases (STDs). Twenty markets were randomly assigned to a CPOL intervention (N == 1,695) and 20 markets to a control condition (N == 1,616). Market employees in the intervention condition reported positive attitudes regarding STD/HIV prevention and more frequent discussions about safe sex than those in the control condition. Compared with baseline, the prevalence of unprotected sexual acts and new STDs were significantly lower within each study condition 24 months later. Although the CPOL intervention achieved its goal of shifting attitudes within food markets, the gains did not lead to the expected behavioral and biological outcomes. [PUBLICATION ABSTRACT] JF - AIDS Education and Prevention AU - Rotheram-Borus, Mary Jane AU - Li, Li AU - Liang, Li-Jung AU - Wen, Yi AU - Wu, Zunyou Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 448 EP - 56 CY - New York PB - Guilford Publications, Inc. VL - 23 IS - 5 SN - 08999546 KW - Medical Sciences--Communicable Diseases KW - Human immunodeficiency virus--HIV KW - Health education KW - Diagnostic tests KW - Sexually transmitted diseases--STD KW - Grocery stores KW - Employees KW - China KW - Young Adult KW - Humans KW - Safe Sex -- statistics & numerical data KW - Interpersonal Relations KW - Peer Group KW - Sexually Transmitted Diseases -- epidemiology KW - Unsafe Sex -- prevention & control KW - China -- epidemiology KW - Adult KW - Commerce KW - Follow-Up Studies KW - Middle Aged KW - Adolescent KW - HIV Infections -- epidemiology KW - Female KW - Male KW - Prevalence KW - Health Promotion -- methods KW - HIV Infections -- prevention & control KW - Health Knowledge, Attitudes, Practice KW - Health Education -- methods KW - Sexually Transmitted Diseases -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/898919896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acriminaljusticeperiodicals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Education+and+Prevention&rft.atitle=Attitudinal%2C+Behavioral%2C+and+Biological+Outcomes+of+a+Community+Popular+Opinion+Leader+Intervention+in+China&rft.au=Rotheram-Borus%2C+Mary+Jane%3BLi%2C+Li%3BLiang%2C+Li-Jung%3BWen%2C+Yi%3BWu%2C+Zunyou&rft.aulast=Rotheram-Borus&rft.aufirst=Mary&rft.date=2011-10-01&rft.volume=23&rft.issue=5&rft.spage=448&rft.isbn=&rft.btitle=&rft.title=AIDS+Education+and+Prevention&rft.issn=08999546&rft_id=info:doi/101521aeap2011235448 LA - English DB - ProQuest Central N1 - Copyright - © 2011 The Guilford Press N1 - Last updated - 2014-04-04 N1 - CODEN - AEPREO N1 - SubjectsTermNotLitGenreText - China DO - http://dx.doi.org/101521aeap2011235448 ER - TY - JOUR T1 - Outcome of advanced NSCLC patients harboring sensitizing EGFR mutations randomized to EGFR tyrosine kinase inhibitors or chemotherapy as first-line treatment: a meta-analysis. AN - 894820576; 21325444 AB - Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) are effective as first-line treatment of advanced non-small-cell lung cancer patients with EGFR mutations (EGFR-M+). We conducted a literature-based meta-analysis to quantify the magnitude of benefit with upfront EGFR TKI in EGFR-M+ patients. Meta-regression and sensitivity analyses were also carried out to identify additional predictors of outcome and to assess the influence of trial design. Five trials (805 patients) were identified (three trials prospectively enrolling EGFR-M+ patients and two retrospective analyses of EGFR-M+ patients). TKI significantly increased progression-free survival (PFS) [hazard ratio (HR) 0.45, 95% confidence interval (CI) 0.36-0.58, P < 0.0001] and overall response rate (ORR) (HR 2.08, 95% CI 1.75-2.46, P < 0.0001)] over chemotherapy, while significantly decreasing neutropenia. No significant difference was observed in overall survival. The rate of exon-19 mutations, female gender, and nonsmoking status were identified as additional predictors of outcome at meta-regression analysis. A significant interaction with trial design was found for both PFS (P = 0.028) and ORR (P = 0.008), suggesting a larger advantage for patients treated within prospective trials. In EGFR-M+ patients, first-line TKI increase both PFS and ORR by ~25%, while significantly decreasing toxicity. The role of additional predictive factors and the influence of trial design on the magnitude of the observed benefit warrant further investigation. JF - Annals of oncology : official journal of the European Society for Medical Oncology AU - Bria, E AU - Milella, M AU - Cuppone, F AU - Novello, S AU - Ceribelli, A AU - Vaccaro, V AU - Sperduti, I AU - Gelibter, A AU - Scagliotti, G V AU - Cognetti, F AU - Giannarelli, D AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Rome, Italy. emiliobria@yahoo.it Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 2277 EP - 2285 VL - 22 IS - 10 KW - Protein Kinase Inhibitors KW - 0 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Sex Factors KW - Humans KW - Male KW - Female KW - Lung Neoplasms -- enzymology KW - Receptor, Epidermal Growth Factor -- antagonists & inhibitors KW - Receptor, Epidermal Growth Factor -- genetics KW - Protein Kinase Inhibitors -- therapeutic use KW - Protein Kinase Inhibitors -- adverse effects KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - Lung Neoplasms -- drug therapy KW - Lung Neoplasms -- genetics KW - Carcinoma, Non-Small-Cell Lung -- enzymology KW - Mutation KW - Carcinoma, Non-Small-Cell Lung -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/894820576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.atitle=Outcome+of+advanced+NSCLC+patients+harboring+sensitizing+EGFR+mutations+randomized+to+EGFR+tyrosine+kinase+inhibitors+or+chemotherapy+as+first-line+treatment%3A+a+meta-analysis.&rft.au=Bria%2C+E%3BMilella%2C+M%3BCuppone%2C+F%3BNovello%2C+S%3BCeribelli%2C+A%3BVaccaro%2C+V%3BSperduti%2C+I%3BGelibter%2C+A%3BScagliotti%2C+G+V%3BCognetti%2C+F%3BGiannarelli%2C+D&rft.aulast=Bria&rft.aufirst=E&rft.date=2011-10-01&rft.volume=22&rft.issue=10&rft.spage=2277&rft.isbn=&rft.btitle=&rft.title=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.issn=1569-8041&rft_id=info:doi/10.1093%2Fannonc%2Fmdq742 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-12 N1 - Date created - 2011-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eval Health Prof. 2002 Jun;25(2):210-24 [12026754] Lancet Oncol. 2001 Aug;2(8):475-82 [11905723] Lung Cancer. 2004 Aug;45(2):143-52 [15246184] BMJ. 1998 Nov 7;317(7168):1309-12 [9804726] Stat Med. 1998 Dec 30;17(24):2815-34 [9921604] Lung Cancer. 2006 Jan;51(1):13-9 [16313999] Anticancer Drugs. 2006 Apr;17(4):401-9 [16549997] Cancer Treat Rev. 2006 Nov;32(7):572-6 [16914268] Nat Rev Cancer. 2007 Mar;7(3):169-81 [17318210] J Clin Oncol. 2007 Aug 1;25(22):3274-80 [17664474] J Clin Oncol. 2008 Sep 10;26(26):4268-75 [18626007] J Clin Oncol. 2008 Sep 10;26(26):4244-52 [18779611] Lancet. 2008 Nov 22;372(9652):1809-18 [19027483] Lung Cancer. 2009 Jan;63(1):50-7 [18565615] Nat Rev Clin Oncol. 2009 Jun;6(6):352-66 [19483740] J Clin Oncol. 2009 Aug 20;27(24):4027-34 [19597023] N Engl J Med. 2009 Sep 3;361(10):947-57 [19692680] N Engl J Med. 2009 Sep 3;361(10):958-67 [19692684] Lung Cancer. 2009 Dec;66(3):386-92 [19304339] Int J Cancer. 2010 Feb 1;126(3):651-5 [19609951] J Clin Oncol. 2009 Dec 20;27(36):6251-66 [19917871] J Clin Oncol. 2010 Feb 10;28(5):713-5 [20038722] Lancet Oncol. 2010 Feb;11(2):121-8 [20022809] J Thorac Oncol. 2010 May;5(5):620-30 [20354456] Lancet Oncol. 2010 Jun;11(6):521-9 [20493771] N Engl J Med. 2010 Jun 24;362(25):2380-8 [20573926] J Thorac Oncol. 2010 Jul;5(7):1011-7 [20502360] J Thorac Oncol. 2010 Jul;5(7):1001-10 [20526205] J Clin Oncol. 2011 Jul 20;29(21):2866-74 [21670455] Oncologist. 2002;7(3):181-7 [12065789] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annonc/mdq742 ER - TY - JOUR T1 - Genomic modeling of tumor onset and progression in a mouse model of aggressive human liver cancer. AN - 894812815; 21771728 AB - A comprehensive understanding of molecular mechanisms driving cancer onset and progression should provide a basis for improving early diagnosis, biomarker discovery and treatment options. A key value of genetically engineered mice for modeling human cancer is the possibility to analyze the entire process of tumor development. Here, we applied functional genomics approach to study step-by-step development of hepatocellular carcinoma (HCC) in the c-Myc/Tgfα transgenic mouse model of aggressive human liver cancer. We report that coexpression of c-Myc and Tgfα induces progressive and cumulative transcriptional alterations in the course of liver oncogenesis. Functional analysis of deregulated genes at the early stage of HCC disease supports a model of active hepatocyte proliferation on the background of chronic oxidative stress generated by a general metabolic disorder. In addition, early and persistent deregulation of numerous immune-related genes suggested that disruption of immune microenvironment may contribute to oncogenic process in this model of accelerated liver carcinogenesis. In particularly, by flow cytometry analysis, we found loss of the major histocompatibility complex class I expression in dysplastic hepatocytes followed by upregulation of numerous activating ligands for natural killer (NK) cells concomitant with a drastic decrease in hepatic NK cell frequency. In conclusion, our study provides a comprehensive characterization of sequential molecular changes during a stepwise progression of preneoplastic lesions toward HCC and highlights a critical role of metabolic disorders and innate immunity at the early stages of liver cancer. JF - Carcinogenesis AU - Coulouarn, Cédric AU - Factor, Valentina M AU - Conner, Elizabeth A AU - Thorgeirsson, Snorri S AD - National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 1434 EP - 1440 VL - 32 IS - 10 KW - Biomarkers, Tumor KW - 0 KW - Proto-Oncogene Proteins c-myc KW - RNA, Messenger KW - Transforming Growth Factor alpha KW - Index Medicus KW - Animals KW - Biomarkers, Tumor -- genetics KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Disease Progression KW - Mice KW - Hepatocytes -- pathology KW - T-Lymphocytes -- pathology KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Mice, Transgenic KW - Biomarkers, Tumor -- metabolism KW - Gene Expression Profiling KW - T-Lymphocytes -- metabolism KW - Flow Cytometry KW - Killer Cells, Natural -- pathology KW - Killer Cells, Natural -- metabolism KW - T-Lymphocytes -- immunology KW - Male KW - Killer Cells, Natural -- immunology KW - Hepatocytes -- metabolism KW - Liver Neoplasms, Experimental -- pathology KW - Liver Neoplasms, Experimental -- etiology KW - Carcinoma, Hepatocellular -- etiology KW - Transforming Growth Factor alpha -- physiology KW - Proto-Oncogene Proteins c-myc -- physiology KW - Carcinoma, Hepatocellular -- pathology KW - Disease Models, Animal KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/894812815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Genomic+modeling+of+tumor+onset+and+progression+in+a+mouse+model+of+aggressive+human+liver+cancer.&rft.au=Coulouarn%2C+C%C3%A9dric%3BFactor%2C+Valentina+M%3BConner%2C+Elizabeth+A%3BThorgeirsson%2C+Snorri+S&rft.aulast=Coulouarn&rft.aufirst=C%C3%A9dric&rft.date=2011-10-01&rft.volume=32&rft.issue=10&rft.spage=1434&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgr133 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-29 N1 - Date created - 2011-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2000 Jul 6;19(29):3225-34 [10918579] J Autoimmun. 2009 Nov-Dec;33(3-4):275-81 [19682859] Cell. 2001 May 18;105(4):445-57 [11371342] Genes Dev. 2001 Jul 15;15(14):1765-70 [11459826] Nature. 2001 Sep 13;413(6852):165-71 [11557981] Nat Genet. 2002 Aug;31(4):339-46 [12149612] Biochem Biophys Res Commun. 2002 Sep 13;297(1):59-64 [12220508] Science. 2002 Oct 11;298(5592):422-4 [12376703] J Clin Invest. 2002 Nov;110(10):1503-13 [12438448] Hepatology. 2004 Sep;40(3):667-76 [15349906] Gastroenterology. 2004 Nov;127(5 Suppl 1):S27-34 [15508094] Cell. 1990 Jun 15;61(6):1137-46 [2350785] Cancer Res. 1993 Apr 15;53(8):1719-23 [8467484] Cell. 1996 Feb 23;84(4):623-31 [8598048] Cancer Res. 1996 May 1;56(9):2137-42 [8616862] Am J Pathol. 1996 Aug;149(2):407-28 [8701981] Cancer Res. 1998 Jan 1;58(1):123-34 [9426068] J Biol Chem. 1998 Jun 19;273(25):15846-53 [9624185] Am J Pathol. 1999 Apr;154(4):1047-55 [10233843] Am J Pathol. 1999 Jun;154(6):1693-700 [10362794] Nat Genet. 2004 Dec;36(12):1306-11 [15565109] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] J Exp Med. 2005 Nov 7;202(9):1279-88 [16275765] J Immunol. 2005 Dec 15;175(12):7791-5 [16339512] Hepatology. 2006 Feb;43(2 Suppl 1):S54-62 [16447271] Nat Rev Immunol. 2006 Oct;6(10):715-27 [16977338] Hepatology. 2006 Oct;44(4):1003-11 [17006931] Cancer Res. 2006 Nov 15;66(22):11005-12 [17108139] Hepatology. 2008 Feb;47(2):729-36 [18167066] Clin Sci (Lond). 2008 Apr;114(7):457-66 [18302533] Hepatology. 2008 Jun;47(6):2059-67 [18506891] Oncogene. 2008 Oct 6;27(45):5932-43 [18836474] Oncogene. 2008 Oct 6;27(45):5944-58 [18836475] Curr Mol Med. 2009 Aug;9(6):667-72 [19689293] Nat Immunol. 2000 Dec;1(6):515-20 [11101874] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgr133 ER - TY - JOUR T1 - A phase II trial of single-agent bevacizumab in patients with recurrent anaplastic glioma. AN - 893978826; 21865400 AB - The purpose of this study was to evaluate the activity of single-agent bevacizumab in patients with recurrent anaplastic glioma and assess correlative advanced imaging parameters. Patients with recurrent anaplastic glioma were treated with bevacizumab 10 mg/kg every 2 weeks. Complete patient evaluations were repeated every 4 weeks. Correlative dynamic contrast-enhanced MR and (18)fluorodeoxyglucose PET imaging studies were obtained to evaluate physiologic changes in tumor and tumor vasculature at time points including baseline, 96 h after the first dose, and after the first 4 weeks of therapy. Median overall survival was 12 months (95% confidence interval [CI]: 6.08-22.8). Median progression-free survival was 2.93 months (95% CI: 2.01-4.93), and 6-month progression-free survival was 20.9% (95% CI: 10.3%-42.5%). Thirteen (43%) patients achieved a partial response. The most common grade ≥ 3 treatment-related toxicities were hypertension, hypophosphatemia, and thromboembolism. Single-agent bevacizumab produces significant radiographic response in patients with recurrent anaplastic glioma but did not meet the 6-month progression-free survival endpoint. Early change in enhancing tumor volume at 4 days after start of therapy was the most significant prognostic factor for overall and progression-free survival. JF - Neuro-oncology AU - Kreisl, Teri N AU - Zhang, Weiting AU - Odia, Yazmin AU - Shih, Joanna H AU - Butman, John A AU - Hammoud, Dima AU - Iwamoto, Fabio M AU - Sul, Joohee AU - Fine, Howard A AD - The Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA. kreislt@mail.nih.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 1143 EP - 1150 VL - 13 IS - 10 KW - Antibodies, Monoclonal, Humanized KW - 0 KW - Antineoplastic Agents KW - Bevacizumab KW - 2S9ZZM9Q9V KW - Index Medicus KW - Magnetic Resonance Imaging KW - Kaplan-Meier Estimate KW - Young Adult KW - Disease-Free Survival KW - Positron-Emission Tomography KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Male KW - Female KW - Brain Neoplasms -- pathology KW - Glioma -- pathology KW - Antibodies, Monoclonal, Humanized -- therapeutic use KW - Glioma -- drug therapy KW - Brain Neoplasms -- drug therapy KW - Brain Neoplasms -- mortality KW - Glioma -- mortality KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893978826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuro-oncology&rft.atitle=A+phase+II+trial+of+single-agent+bevacizumab+in+patients+with+recurrent+anaplastic+glioma.&rft.au=Kreisl%2C+Teri+N%3BZhang%2C+Weiting%3BOdia%2C+Yazmin%3BShih%2C+Joanna+H%3BButman%2C+John+A%3BHammoud%2C+Dima%3BIwamoto%2C+Fabio+M%3BSul%2C+Joohee%3BFine%2C+Howard+A&rft.aulast=Kreisl&rft.aufirst=Teri&rft.date=2011-10-01&rft.volume=13&rft.issue=10&rft.spage=1143&rft.isbn=&rft.btitle=&rft.title=Neuro-oncology&rft.issn=1523-5866&rft_id=info:doi/10.1093%2Fneuonc%2Fnor091 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-13 N1 - Date created - 2011-09-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 1999 Aug;17(8):2572-8 [10561324] Cancer Chemother Pharmacol. 2011 Sep;68(3):631-41 [21120480] J Clin Oncol. 1990 Jul;8(7):1277-80 [2358840] Comput Biomed Res. 1996 Jun;29(3):162-73 [8812068] Comput Methods Programs Biomed. 2006 Dec;84(2-3):76-85 [17050032] Neuro Oncol. 2008 Apr;10(2):162-70 [18356283] J Neurosurg. 2008 Aug;109(2):268-72 [18671639] Clin Cancer Res. 2008 Nov 1;14(21):7068-73 [18981004] Acta Oncol. 2009;48(1):52-8 [19031176] J Neurooncol. 2009 Feb;91(3):329-36 [18953493] J Clin Oncol. 2009 Feb 10;27(5):740-5 [19114704] J Neurooncol. 2009 Apr;92(2):149-55 [19043778] Cancer Res. 2009 Jul 1;69(13):5296-300 [19549889] J Clin Oncol. 2009 Oct 1;27(28):4733-40 [19720927] J Magn Reson Imaging. 2010 Feb;31(2):490-501 [20099364] J Clin Oncol. 2010 Apr 10;28(11):1963-72 [20231676] J Neurosurg. 1977 Sep;47(3):329-35 [894339] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/neuonc/nor091 ER - TY - JOUR T1 - Defective dendritic cell generation from monocytes is a potential reason for poor therapeutic efficacy of interferon α2b (IFNα2b) in cervical cancer. AN - 892950680; 21925117 AB - Despite being a pleiotropic cytokine, the therapeutic potential of interferon α2b (IFNα2b) is debatable. Thus, the need for identifying predictive marker(s) for patients who are most likely to benefit from the treatment is pivotal for avoiding the exposure of nonresponsive patients to the toxicity of the treatment. To account for the attenuated efficacy of the drug, we have verified its dendritic cell (DC) maturating ability from monocytes of cervical cancer stage IIIB (CaCx-IIIB) patients. First, we evaluated the status of monocytes from CaCx-IIIB and healthy women by conducting flow cytometric studies of various activation markers and a cytokine analysis by enzyme-linked immunosorbent assay (ELISA) and flow cytometry. Immature DCs were then generated from these monocytes and matured with low-dose IFNα2b (1500 units/mL). A functional and phenotypic comparative analysis of these matured DCs was performed by flow cytometric, proliferative, cytotoxic, and enzyme-linked immunosorbent assays. Our study shows that monocytes isolated from CaCx-IIIB are impaired, and in vitro maturation with IFNα2b did not significantly improve the functional repertoire of DCs generated from these monocytes in comparison with healthy controls. This impairment of monocytes might be a plausible reason for the attenuated efficacy of this drug alone in treating CaCx-IIIB patients, and this imbalance of immune parameters associated with the stage of malignancy might be considered an effective marker to design a proper therapeutic regimen. Copyright © 2011 Mosby, Inc. All rights reserved. JF - Translational research : the journal of laboratory and clinical medicine AU - Roy, Soumyabrata AU - Goswami, Shyamal AU - Bose, Anamika AU - Goswami, Kuntal Kanti AU - Sarkar, Koustav AU - Chakraborty, Krishnendu AU - Chakraborty, Tathagata AU - Pal, Smarajit AU - Haldar, Atanu AU - Basu, Parthasarathi AU - Biswas, Jaydip AU - Baral, Rathindranath AD - Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata 700026, India. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 200 EP - 213 VL - 158 IS - 4 KW - Cytokines KW - 0 KW - Interferon-alpha KW - Recombinant Proteins KW - Receptor, Interferon alpha-beta KW - 156986-95-7 KW - interferon alfa-2b KW - 43K1W2T1M6 KW - Abridged Index Medicus KW - Index Medicus KW - Treatment Failure KW - Antigen Presentation -- drug effects KW - Cytokines -- biosynthesis KW - Humans KW - Aged KW - Translational Medical Research KW - Cell Differentiation -- immunology KW - Lymphocyte Activation KW - CD8-Positive T-Lymphocytes -- immunology KW - Adult KW - In Vitro Techniques KW - Case-Control Studies KW - Middle Aged KW - Cell Differentiation -- drug effects KW - Receptor, Interferon alpha-beta -- metabolism KW - Female KW - Dendritic Cells -- pathology KW - Interferon-alpha -- therapeutic use KW - Interferon-alpha -- adverse effects KW - Dendritic Cells -- immunology KW - Uterine Cervical Neoplasms -- drug therapy KW - Monocytes -- immunology KW - Dendritic Cells -- drug effects KW - Monocytes -- pathology KW - Monocytes -- drug effects KW - Uterine Cervical Neoplasms -- immunology KW - Uterine Cervical Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/892950680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Translational+research+%3A+the+journal+of+laboratory+and+clinical+medicine&rft.atitle=Defective+dendritic+cell+generation+from+monocytes+is+a+potential+reason+for+poor+therapeutic+efficacy+of+interferon+%CE%B12b+%28IFN%CE%B12b%29+in+cervical+cancer.&rft.au=Roy%2C+Soumyabrata%3BGoswami%2C+Shyamal%3BBose%2C+Anamika%3BGoswami%2C+Kuntal+Kanti%3BSarkar%2C+Koustav%3BChakraborty%2C+Krishnendu%3BChakraborty%2C+Tathagata%3BPal%2C+Smarajit%3BHaldar%2C+Atanu%3BBasu%2C+Parthasarathi%3BBiswas%2C+Jaydip%3BBaral%2C+Rathindranath&rft.aulast=Roy&rft.aufirst=Soumyabrata&rft.date=2011-10-01&rft.volume=158&rft.issue=4&rft.spage=200&rft.isbn=&rft.btitle=&rft.title=Translational+research+%3A+the+journal+of+laboratory+and+clinical+medicine&rft.issn=1878-1810&rft_id=info:doi/10.1016%2Fj.trsl.2011.03.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-08 N1 - Date created - 2011-09-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Transl Res. 2011 Oct;158(4):197-9 [21925116] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.trsl.2011.03.003 ER - TY - JOUR T1 - High prevalence of human papillomavirus infection in Eastern European and West African women immigrants in South Italy. AN - 890679307; 21917007 AB - Surveillance of human papillomavirus (HPV) prevalence and genotype distribution in migrant women from middle and low-income countries to developed countries is limited. The aim of this study was to analyze the spectrum of HPV genotypes and prevalence of cervical abnormalities in women emigrated mainly from Eastern Europe and West Africa and living in Southern Italy. The study included 233 migrant and 98 Italian-born women who self-referred to two gynecological outpatient clinics in the Campania region. Cervical specimens were subjected to cytological examination and viral testing by broad spectrum PCR. The prevalence rates of HPV infection were 57.9% and 94.1% among migrant and 19.4% and 88.5% among Italian women with normal and abnormal cytology respectively. HPV infection was detected in 56.1% of Southern and Eastern European, 62.5% of Central and South American, 55.5% of West African, and 73.3% of Southern Asian women with normal cervix. Among the 140 HPV-positive migrants, a total of 28 mucosal HPV genotypes were identified of which 11 types (HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, and 58), epidemiological classified as carcinogenic to humans (group 1), accounted for 73.4% of all infections. As expected, HPV16 was the most common viral type in all groups with frequency rates ranging from 12.5% in African to 30.1% in Eastern and Southern European women. In conclusion, the estimated prevalence of HPV infection among migrant women is very high, probably reflecting either lifestyle or high incidence of HPV in their country of origin. The implementation of vaccination strategies and cervical cancer surveillance are critical for women in this risk group. © 2011 The Authors. APMIS © 2011 APMIS. JF - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica AU - Tornesello, Maria Lina AU - Cassese, Rosaria AU - De Rosa, Nicoletta AU - Buonaguro, Luigi AU - Masucci, Anna AU - Vallefuoco, Gabriele AU - Palmieri, Stefano AU - Schiavone, Vincenzo AU - Piccoli, Roberto AU - Buonaguro, Franco M AD - Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute, "Fond. Pascale", Naples, Italy. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 701 EP - 709 VL - 119 IS - 10 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Young Adult KW - Uterine Cervical Diseases -- diagnosis KW - Chi-Square Distribution KW - Humans KW - Uterine Cervical Diseases -- virology KW - Aged KW - Europe, Eastern -- ethnology KW - Polymerase Chain Reaction KW - DNA, Viral -- chemistry KW - Adult KW - Vaginal Smears KW - Cervix Uteri -- cytology KW - Cervix Uteri -- virology KW - Middle Aged KW - Italy -- epidemiology KW - Uterine Cervical Diseases -- epidemiology KW - DNA, Viral -- genetics KW - Female KW - Prevalence KW - Africa -- ethnology KW - Papillomavirus Infections -- epidemiology KW - Papillomavirus Infections -- diagnosis KW - Papillomaviridae -- isolation & purification KW - Papillomavirus Infections -- virology KW - Papillomaviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/890679307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=APMIS+%3A+acta+pathologica%2C+microbiologica%2C+et+immunologica+Scandinavica&rft.atitle=High+prevalence+of+human+papillomavirus+infection+in+Eastern+European+and+West+African+women+immigrants+in+South+Italy.&rft.au=Tornesello%2C+Maria+Lina%3BCassese%2C+Rosaria%3BDe+Rosa%2C+Nicoletta%3BBuonaguro%2C+Luigi%3BMasucci%2C+Anna%3BVallefuoco%2C+Gabriele%3BPalmieri%2C+Stefano%3BSchiavone%2C+Vincenzo%3BPiccoli%2C+Roberto%3BBuonaguro%2C+Franco+M&rft.aulast=Tornesello&rft.aufirst=Maria&rft.date=2011-10-01&rft.volume=119&rft.issue=10&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=APMIS+%3A+acta+pathologica%2C+microbiologica%2C+et+immunologica+Scandinavica&rft.issn=1600-0463&rft_id=info:doi/10.1111%2Fj.1600-0463.2011.02784.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-08 N1 - Date created - 2011-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1600-0463.2011.02784.x ER - TY - JOUR T1 - The cannabinoid receptor inverse agonist AM251 regulates the expression of the EGF receptor and its ligands via destabilization of oestrogen-related receptor α protein. AN - 888338721; 21449913 AB - AM251 is an inverse agonist of the cannabinoid 1 receptor (CB(1)R) that can exert 'off-target' effects in vitro and in CB(1)R knock-out mice. AM251 is also potent at modulating tumour cell growth, suggesting that growth factor-mediated oncogenic signalling could be regulated by AM251. Since dysregulation of the EGF receptor has been associated with carcinogenesis, we examined AM251 regulation of EGF receptor (EGFR) expression and function. The various biological functions of AM251 were measured in CB(1)R-negative human cancer cells. Pharmacological and genetic approaches were used to validate the data. The mRNA levels for EGFR and its associated ligands, including HB-EGF, were induced several fold in PANC-1 and HCT116 cells in response to AM251. This event was associated with enhanced expression of EGFR on the cell surface with concomitant increase in EGF-induced cellular responses in AM251-treated cells. Exposure to XCT790, a synthetic inverse agonist of the orphan nuclear oestrogen-related receptor α (ERRα), also induced EGFR and HB-EGF expression to the same extent as AM251, whereas pretreatment with the ERRα-selective agonist, biochanin A, blunted AM251 actions. AM251 promoted the degradation of ERRα protein without loss of the corresponding mRNA. Knock-down of ERRα by siRNA-based approach led to constitutive induction of EGFR and HB-EGF levels, and eliminated the biological responses of AM251 and XCT790. Finally, AM251 displaced diethylstilbestrol prebound to the ligand-binding domain of ERRα. AM251 up-regulates EGFR expression and signalling via a novel non-CB(1)R-mediated pathway involving destabilization of ERRα protein in selected cancer cell lines. British Journal of Pharmacology © 2011 The British Pharmacological Society. Published 2011. This article is a U.S. Government work and is in the public domain in the USA. JF - British journal of pharmacology AU - Fiori, J L AU - Sanghvi, M AU - O'Connell, M P AU - Krzysik-Walker, S M AU - Moaddel, R AU - Bernier, M AD - Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 1026 EP - 1040 VL - 164 IS - 3 KW - ERRalpha estrogen-related receptor KW - 0 KW - HBEGF protein, human KW - Hbegf protein, mouse KW - Heparin-binding EGF-like Growth Factor KW - Intercellular Signaling Peptides and Proteins KW - Ligands KW - Nitriles KW - Orphan Nuclear Receptors KW - Piperidines KW - Pyrazoles KW - RNA, Messenger KW - Receptor, Cannabinoid, CB1 KW - Receptors, Estrogen KW - Thiazoles KW - XCT790 KW - AM 251 KW - 3I4FA44MAI KW - Epidermal Growth Factor KW - 62229-50-9 KW - Genistein KW - DH2M523P0H KW - EGFR protein, human KW - EC 2.7.10.1 KW - Receptor, Epidermal Growth Factor KW - biochanin A KW - U13J6U390T KW - Index Medicus KW - Orphan Nuclear Receptors -- metabolism KW - Nitriles -- pharmacology KW - Humans KW - Cell Line, Tumor KW - HCT116 Cells KW - RNA, Messenger -- genetics KW - Protein Binding KW - RNA, Messenger -- biosynthesis KW - Thiazoles -- pharmacology KW - Intercellular Signaling Peptides and Proteins -- genetics KW - Genistein -- pharmacology KW - Up-Regulation -- drug effects KW - Epidermal Growth Factor -- metabolism KW - Intercellular Signaling Peptides and Proteins -- metabolism KW - Receptors, Estrogen -- antagonists & inhibitors KW - Piperidines -- pharmacology KW - Pyrazoles -- pharmacology KW - Receptor, Epidermal Growth Factor -- metabolism KW - Receptor, Epidermal Growth Factor -- genetics KW - Receptor, Cannabinoid, CB1 -- metabolism KW - Receptors, Estrogen -- metabolism KW - Receptors, Estrogen -- agonists KW - Receptor, Epidermal Growth Factor -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888338721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+pharmacology&rft.atitle=The+cannabinoid+receptor+inverse+agonist+AM251+regulates+the+expression+of+the+EGF+receptor+and+its+ligands+via+destabilization+of+oestrogen-related+receptor+%CE%B1+protein.&rft.au=Fiori%2C+J+L%3BSanghvi%2C+M%3BO%27Connell%2C+M+P%3BKrzysik-Walker%2C+S+M%3BMoaddel%2C+R%3BBernier%2C+M&rft.aulast=Fiori&rft.aufirst=J&rft.date=2011-10-01&rft.volume=164&rft.issue=3&rft.spage=1026&rft.isbn=&rft.btitle=&rft.title=British+journal+of+pharmacology&rft.issn=1476-5381&rft_id=info:doi/10.1111%2Fj.1476-5381.2011.01384.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-19 N1 - Date created - 2011-09-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Endocrinol. 2008 Mar;22(3):570-84 [18063693] Growth Horm IGF Res. 2008 Oct;18(5):424-33 [18424208] Anal Chem. 2008 Oct 1;80(19):7571-5 [18693748] Mol Cell Biol. 2008 Nov;28(22):6785-95 [18794372] Mini Rev Med Chem. 2008 Nov;8(13):1418-28 [18991757] J Biochem. 2009 Jan;145(1):13-20 [18845565] Nat Protoc. 2009;4(2):197-205 [19180089] Cell Mol Life Sci. 2009 Mar;66(5):773-87 [19011757] Cancer Metastasis Rev. 2009 Jun;28(1-2):151-66 [19153669] J Biol Chem. 2009 May 1;284(18):12328-38 [19286662] J Cell Physiol. 2009 Jul;220(1):35-44 [19347870] J Steroid Biochem Mol Biol. 2009 Mar;114(1-2):106-12 [19429439] Mol Cell Biol. 2009 Aug;29(15):4091-102 [19451226] Mol Cell Endocrinol. 2010 Feb 5;315(1-2):314-8 [19822186] Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1210-8 [20215575] J Pharm Biomed Anal. 2010 Nov 2;53(3):777-80 [20542653] World J Gastroenterol. 2004 Mar 15;10(6):860-3 [15040033] FEBS Lett. 1999 Sep 24;458(3):400-4 [10570948] Endocrinology. 2000 Jan;141(1):118-26 [10614630] Cell. 2000 Jan 7;100(1):57-70 [10647931] Br J Pharmacol. 2000 Jan;129(2):227-30 [10694225] Cancer. 2000 May 1;88(9):2000-9 [10813710] Br J Cancer. 2001 Apr 6;84(7):926-35 [11286473] Genes Dev. 2001 Apr 1;15(7):833-8 [11297507] Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8880-4 [11447273] Biochem Biophys Res Commun. 2001 Sep 7;286(5):1144-52 [11527419] Endocrinology. 2001 Oct;142(10):4572-5 [11564725] Eur J Cancer. 2001 Sep;37 Suppl 4:S9-15 [11597399] Eur J Pharmacol. 2001 Jul 27;424(3):211-9 [11672565] Hypertension. 2002 Feb;39(2):251-7 [11847193] Cancer Res. 2002 Nov 15;62(22):6510-8 [12438245] Prostate. 2003 Jun 15;56(1):1-12 [12746841] Oncogene. 2003 Jul 31;22(31):4875-81 [12894229] Mol Cell Biol. 2003 Nov;23(22):7947-56 [14585956] Biochem Biophys Res Commun. 2004 Feb 20;314(4):964-70 [14751226] Cancer Res. 2004 Mar 15;64(6):1943-50 [15026328] Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6472-7 [15087503] Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8912-7 [15184675] Cancer Res. 2004 Jul 1;64(13):4670-6 [15231680] Mol Pharmacol. 2004 Aug;66(2):204-8 [15266010] Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H595-600 [15059774] Mol Cell Biol. 2004 Oct;24(20):9079-91 [15456881] J Med Chem. 2004 Nov 4;47(23):5593-6 [15509154] J Neurosci. 1991 Feb;11(2):563-83 [1992016] J Comp Neurol. 1993 Jan 22;327(4):535-50 [8440779] Prostate. 1993;22(4):335-45 [8497428] Proc Soc Exp Biol Med. 1993 Oct;204(1):110-6 [8372093] Cytometry. 1995 May 1;20(1):43-52 [7600899] Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6981-5 [7542783] Cell Growth Differ. 1998 Dec;9(12):1007-14 [9869301] J Neurosci. 2005 Jan 19;25(3):662-71 [15659603] Cancer Res. 2005 Mar 1;65(5):1635-41 [15753356] Lancet. 2005 Apr 16-22;365(9468):1389-97 [15836887] J Mol Med (Berl). 2005 Jun;83(6):457-67 [15770498] Eur J Cancer. 2005 Jul;41(10):1487-94 [15949936] Behav Pharmacol. 2005 Sep;16(5-6):405-13 [16148445] Endocrinology. 2005 Oct;146(10):4292-301 [15994343] Gut. 2005 Dec;54(12):1741-50 [16099783] Mol Cell Biol. 2005 Dec;25(24):10684-94 [16314495] J Med Food. 2005 Winter;8(4):431-8 [16379552] PLoS Med. 2005 Nov;2(11):e313 [16187797] Curr Top Med Chem. 2006;6(3):203-15 [16515477] Gut. 2006 Apr;55(4):519-28 [16174661] Cancer Res. 2006 Jul 1;66(13):6615-21 [16818634] Endocr Relat Cancer. 2006 Dec;13 Suppl 1:S25-32 [17259555] Biochemistry. 2007 Aug 28;46(34):9795-804 [17676930] Biochem Biophys Res Commun. 2007 Nov 3;362(4):928-34 [17765871] J Biol Chem. 2007 Sep 28;282(39):28328-34 [17631492] Front Biosci. 2008;13:1857-65 [17981673] Br J Pharmacol. 2007 Dec;152(7):1092-101 [17876302] Mol Cell. 2007 Dec 14;28(5):730-8 [18082598] Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2699-704 [18263732] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1476-5381.2011.01384.x ER - TY - JOUR T1 - Computational strategy for tuning spectral properties of red fluorescent proteins. AN - 879101881; 21652139 AB - Computational methods of quantum chemistry are used to characterize structures and vertical excitation energies of the S(0)-S(1) optical transitions in the chromophore binding pockets of the red fluorescent proteins DsRed and of its artificial mutant mCherry. As previously shown, optimizing the equilibrium geometry configurations with B3LYP density functional theory, followed by ZINDO calculations of the electronic excitations, yields positions of the optical bands in good agreement with experimental data. These large scale quantum calculations elucidate the role of the hydrogen bonded network as well as point mutations in the absorption spectra of the DsRed and mCherry proteins. The effect of an external electric field applied to the fluorescent protein chromophores is examined and shows that such fields may result in large shifts in spectral bands. These strategies can be applied for rational design of the fluorescent proteins by site-directed mutagenesis. Copyright © 2011 Elsevier B.V. All rights reserved. JF - Biophysical chemistry AU - Topol, I AU - Collins, J AU - Savitsky, A AU - Nemukhin, A AD - Advanced Biomedical Computing Center, Information Systems Program, SAIC- Frederick Inc., NCI-Frederick, MD 21702-1201, USA. topoli@mail.nih.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 91 EP - 95 VL - 158 IS - 2-3 KW - Luminescent Proteins KW - 0 KW - red fluorescent protein KW - Index Medicus KW - Quantum Theory KW - Animals KW - Models, Molecular KW - Point Mutation KW - Electricity KW - Protein Conformation KW - Binding Sites KW - Anthozoa -- chemistry KW - Luminescent Proteins -- chemistry KW - Luminescent Proteins -- genetics KW - Anthozoa -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879101881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biophysical+chemistry&rft.atitle=Computational+strategy+for+tuning+spectral+properties+of+red+fluorescent+proteins.&rft.au=Topol%2C+I%3BCollins%2C+J%3BSavitsky%2C+A%3BNemukhin%2C+A&rft.aulast=Topol&rft.aufirst=I&rft.date=2011-10-01&rft.volume=158&rft.issue=2-3&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Biophysical+chemistry&rft.issn=1873-4200&rft_id=info:doi/10.1016%2Fj.bpc.2011.05.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-08 N1 - Date created - 2011-07-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bpc.2011.05.016 ER - TY - JOUR T1 - Microarray analysis of sexually dimorphic gene expression in human minor salivary glands AN - 1399905117; 15995122 AB - Objective: We hypothesized that differential mRNA transcription between the sexes may be linked to the 9:1 female-to-male gender-related relative risk for the development of Sjogren's syndrome (SS), an autoimmune disease that leads to inflammation and dysfunction in the lachrymal and salivary glands. Subjects and Methods: RNA from minor salivary glands was collected from nine healthy volunteers (four men and five women) and analyzed using the Agilent 444K human microarray platform. Differential expression was confirmed by qRT-PCR. Results: Comparison of the transcriptome of minor salivary glands from normal male and female volunteers with that of salivary glands and secretory epithelia identified a number of gender, species, and tissue-specific gene expression patterns. These differences include, but are not limited to, a diverse set of genes involved in immune modulation, chemotactic control, inhibition of complement, metabolism, and neurogenesis. Conclusion: Analysis of these changes provides insight into the protective and predisposing molecular factors that may be involved in the development of Sjogren's syndrome. Some of the gene changes observed in this study correlate with previously observed sexual dimorphisms in salivary gland function and also illustrate several new targets for further investigation.Original Abstract: Oral Diseases (2011) 17, 653-661 JF - Oral Diseases AU - Michael, D AU - Soi, S AU - Cabera-Perez, J AU - Weller, M AU - Alexander, S AU - Alevizos, I AU - Illei, G G AU - Chiorini, JA AD - Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Center Drive, MD, USA Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 653 EP - 661 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 17 IS - 7 SN - 1354-523X, 1354-523X KW - Biotechnology and Bioengineering Abstracts KW - Risk assessment KW - Sexual dimorphism KW - Autoimmune diseases KW - Transcription KW - Salivary gland KW - Immunomodulation KW - DNA microarrays KW - Inflammation KW - Sjogren's syndrome KW - Gene expression KW - Neurogenesis KW - Metabolism KW - Sex KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1399905117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oral+Diseases&rft.atitle=Microarray+analysis+of+sexually+dimorphic+gene+expression+in+human+minor+salivary+glands&rft.au=Michael%2C+D%3BSoi%2C+S%3BCabera-Perez%2C+J%3BWeller%2C+M%3BAlexander%2C+S%3BAlevizos%2C+I%3BIllei%2C+G+G%3BChiorini%2C+JA&rft.aulast=Michael&rft.aufirst=D&rft.date=2011-10-01&rft.volume=17&rft.issue=7&rft.spage=653&rft.isbn=&rft.btitle=&rft.title=Oral+Diseases&rft.issn=1354523X&rft_id=info:doi/10.1111%2Fj.1601-0825.2011.01816.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-07-01 N1 - Document feature - figure 4 N1 - Last updated - 2013-08-12 N1 - SubjectsTermNotLitGenreText - Risk assessment; Sexual dimorphism; Autoimmune diseases; Transcription; Salivary gland; DNA microarrays; Immunomodulation; Inflammation; Gene expression; Sjogren's syndrome; Neurogenesis; Metabolism; Sex DO - http://dx.doi.org/10.1111/j.1601-0825.2011.01816.x ER - TY - JOUR T1 - Erionite exposure in North Dakota and in the turkish villages with mesothelioma AN - 1356356684; 2013-041950 AB - Exposure to erionite, an asbestos-like mineral, causes unprecedented rates of malignant mesothelioma (MM) mortality in some Turkish villages. Erionite deposits are present in at least 12 US States. We investigated whether increased urban development has led to erionite exposure in the US and after preliminary exploration, focused our studies on Dunn County, North Dakota (ND). In Dunn County, ND we discovered that over the past 3 decades, more than 300 miles of roads were surfaced with erionite-containing gravel. To determine potential health implications, we compared erionite from the Turkish villages to that from ND. Our study evaluated airborne point exposure concentrations, examined the physical and chemical properties of erionite, and examined the hallmarks of mesothelial cell transformation in vitro and in vivo. Airborne erionite concentrations measured in ND along roadsides, indoors and inside vehicles, including school buses, equaled or exceeded concentrations in Boyali, where 6.25% of all deaths are caused by MM. With the exception of outdoor samples along roadsides, ND concentrations were lower than those measured in Turkish villages with MM-mortality ranging from 20-50%. The physical and chemical properties of erionite from Turkey and ND are very similar and they showed identical biological activities. Considering the known 30-60 years latency for MM development, there is reason for concern for increased risk in ND in the future. Our findings indicate that implementation of novel preventive and early detection programs in ND and other erionite-rich areas of the US, similar to efforts currently being undertaken in Turkey, is warranted. JF - Abstracts with Programs - Geological Society of America AU - Carbone, Michele AU - Yang, Haining AU - Brass, Brian AU - Dogan, Ahmet Umran AU - Partridge, Charles R AU - Pass, Harvey I AU - Steele, Ian M AU - Tuncer, Murat AU - Way, Steve AU - Miller, Aubrey AU - Anonymous Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 418 PB - Geological Society of America (GSA), Boulder, CO VL - 43 IS - 5 SN - 0016-7592, 0016-7592 KW - United States KW - silicates KW - erionite KW - pollutants KW - Turkey KW - pollution KW - North Dakota KW - toxicity KW - zeolite group KW - mesothelioma KW - framework silicates KW - Asia KW - Middle East KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1356356684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Erionite+exposure+in+North+Dakota+and+in+the+turkish+villages+with+mesothelioma&rft.au=Carbone%2C+Michele%3BYang%2C+Haining%3BBrass%2C+Brian%3BDogan%2C+Ahmet+Umran%3BPartridge%2C+Charles+R%3BPass%2C+Harvey+I%3BSteele%2C+Ian+M%3BTuncer%2C+Murat%3BWay%2C+Steve%3BMiller%2C+Aubrey%3BAnonymous&rft.aulast=Carbone&rft.aufirst=Michele&rft.date=2011-10-01&rft.volume=43&rft.issue=5&rft.spage=418&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2011 annual meeting N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2013-01-01 N1 - PubXState - CO N1 - Last updated - 2013-05-30 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - Asia; erionite; framework silicates; mesothelioma; Middle East; North Dakota; pollutants; pollution; silicates; toxicity; Turkey; United States; zeolite group ER - TY - JOUR T1 - Coiled-coil domains enhance the membrane association of Salmonella type III effectors AN - 1348481052; 15929323 AB - Coiled-coil domains in eukaryotic and prokaryotic proteins contribute to diverse structural and regulatory functions. Here we have used in silico analysis to predict which proteins in the proteome of the enteric pathogen, Salmonella enterica serovar Typhimurium, harbour coiled-coil domains. We found that coiled-coil domains are especially prevalent in virulence-associated proteins, including type III effectors. Using SopB as a model coiled-coil domain type III effector, we have investigated the role of this motif in various aspects of effector function including chaperone binding, secretion and translocation, protein stability, localization and biological activity. Compared with wild-type SopB, SopB coiled-coil mutants were unstable, both inside bacteria and after translocation into host cells. In addition, the putative coiled-coil domain was required for the efficient membrane association of SopB in host cells. Since many other Salmonella effectors were predicted to contain coiled-coil domains, we also investigated the role of this motif in their intracellular targeting in mammalian cells. Mutation of the predicted coiled-coil domains in PipB2, SseJ and SopD2 also eliminated their membrane localization in mammalian cells. These findings suggest that coiled-coil domains represent a common membrane-targeting determinant for Salmonella type III effectors. JF - Cellular Microbiology AU - Knodler, Leigh A AU - Ibarra, JAntonio AU - Perez-Rueda, Ernesto AU - Yip, Calvin K AU - Steele-Mortimer, Olivia AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, USA Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1497 EP - 1517 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 13 IS - 10 SN - 1462-5814, 1462-5814 KW - Microbiology Abstracts B: Bacteriology KW - Protein transport KW - Mammalian cells KW - Salmonella enterica KW - Secretion KW - Chaperones KW - Pathogens KW - Mutation KW - Translocation KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1348481052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Microbiology&rft.atitle=Coiled-coil+domains+enhance+the+membrane+association+of+Salmonella+type+III+effectors&rft.au=Knodler%2C+Leigh+A%3BIbarra%2C+JAntonio%3BPerez-Rueda%2C+Ernesto%3BYip%2C+Calvin+K%3BSteele-Mortimer%2C+Olivia&rft.aulast=Knodler&rft.aufirst=Leigh&rft.date=2011-10-01&rft.volume=13&rft.issue=10&rft.spage=1497&rft.isbn=&rft.btitle=&rft.title=Cellular+Microbiology&rft.issn=14625814&rft_id=info:doi/10.1111%2Fj.1462-5822.2011.01635.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Document feature - figure 8 N1 - Last updated - 2013-05-17 N1 - SubjectsTermNotLitGenreText - Protein transport; Mammalian cells; Secretion; Chaperones; Pathogens; Translocation; Mutation; Salmonella enterica DO - http://dx.doi.org/10.1111/j.1462-5822.2011.01635.x ER - TY - JOUR T1 - Magnetic Resonance Imaging/Ultrasound Fusion Guided Prostate Biopsy Improves Cancer Detection Following Transrectal Ultrasound Biopsy and Correlates With Multiparametric Magnetic Resonance Imaging AN - 1238122542; 15796452 AB - Purpose: A novel platform was developed that fuses pre-biopsy magnetic resonance imaging with real-time transrectal ultrasound imaging to identify and biopsy lesions suspicious for prostate cancer. The cancer detection rates for the first 101 patients are reported. Materials and Methods: This prospective, single institution study was approved by the institutional review board. Patients underwent 3.0 T multiparametric magnetic resonance imaging with endorectal coil, which included T2-weighted, spectroscopic, dynamic contrast enhanced and diffusion weighted magnetic resonance imaging sequences. Lesions suspicious for cancer were graded according to the number of sequences suspicious for cancer as low (2 or less), moderate (3) and high (4) suspicion. Patients underwent standard 12-core transrectal ultrasound biopsy and magnetic resonance imaging/ultrasound fusion guided biopsy with electromagnetic tracking of magnetic resonance imaging lesions. Chi-square and within cluster resampling analyses were used to correlate suspicion on magnetic resonance imaging and the incidence of cancer detected on biopsy. Results: Mean patient age was 63 years old. Median prostate specific antigen at biopsy was 5.8 ng/ml and 90.1% of patients had a negative digital rectal examination. Of patients with low, moderate and high suspicion on magnetic resonance imaging 27.9%, 66.7% and 89.5% were diagnosed with cancer, respectively (p 0.0001). Magnetic resonance imaging/ultrasound fusion guided biopsy detected more cancer per core than standard 12-core transrectal ultrasound biopsy for all levels of suspicion on magnetic resonance imaging. Conclusions: Prostate cancer localized on magnetic resonance imaging may be targeted using this novel magnetic resonance imaging/ultrasound fusion guided biopsy platform. Further research is needed to determine the role of this platform in cancer detection, active surveillance and focal therapy, and to determine which patients may benefit. JF - Journal of Urology AU - Pinto, Peter A AU - Chung, Paul H AU - Rastinehad, Ardeshir R AU - Baccala, Angelo A AU - Kruecker, Jochen AU - Benjamin, Compton J AU - Xu, Sheng AU - Yan, Pingkun AU - Kadoury, Samuel AU - Chua, Celene AU - Locklin, Julia K AU - Turkbey, Baris AU - Shih, Joanna H AU - Gates, Stacey P AU - Buckner, Carey AU - Bratslavsky, Gennady AU - Linehan, WMarston AU - Glossop, Neil D AU - Choyke, Peter L AU - Wood, Bradford J AD - Urologic Oncology Branch, Center for Cancer Research, Clinical Center & National Cancer Institute, National Institutes of Health, Bethesda, Maryland, pintop@mail.nih.gov Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1281 EP - 1285 PB - Elsevier B.V. VL - 186 IS - 4 SN - 0022-5347, 0022-5347 KW - Biotechnology and Bioengineering Abstracts KW - Age KW - Biopsy KW - Diffusion KW - Magnetic resonance imaging KW - Prostate cancer KW - Rectum KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1238122542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Urology&rft.atitle=Magnetic+Resonance+Imaging%2FUltrasound+Fusion+Guided+Prostate+Biopsy+Improves+Cancer+Detection+Following+Transrectal+Ultrasound+Biopsy+and+Correlates+With+Multiparametric+Magnetic+Resonance+Imaging&rft.au=Pinto%2C+Peter+A%3BChung%2C+Paul+H%3BRastinehad%2C+Ardeshir+R%3BBaccala%2C+Angelo+A%3BKruecker%2C+Jochen%3BBenjamin%2C+Compton+J%3BXu%2C+Sheng%3BYan%2C+Pingkun%3BKadoury%2C+Samuel%3BChua%2C+Celene%3BLocklin%2C+Julia+K%3BTurkbey%2C+Baris%3BShih%2C+Joanna+H%3BGates%2C+Stacey+P%3BBuckner%2C+Carey%3BBratslavsky%2C+Gennady%3BLinehan%2C+WMarston%3BGlossop%2C+Neil+D%3BChoyke%2C+Peter+L%3BWood%2C+Bradford+J&rft.aulast=Pinto&rft.aufirst=Peter&rft.date=2011-10-01&rft.volume=186&rft.issue=4&rft.spage=1281&rft.isbn=&rft.btitle=&rft.title=Journal+of+Urology&rft.issn=00225347&rft_id=info:doi/10.1016%2Fj.juro.2011.05.078 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-12-01 N1 - Last updated - 2012-12-28 N1 - SubjectsTermNotLitGenreText - Age; Rectum; Prostate cancer; Magnetic resonance imaging; Diffusion; Biopsy; Ultrasound DO - http://dx.doi.org/10.1016/j.juro.2011.05.078 ER - TY - JOUR T1 - The Cochrane Students Journal Club and Creating a Secondary Learning Resource for Gathering and Appraising Evidence: An Example of Rational Use of Medicines to Prevent Malaria Relapse AN - 1238109572; 17298076 AB - In the current era of evidence-based healthcare, online learning resources provide accessible and affordable training and teaching resources to stimulate the next generation of medical professionals. In the first of a series of qualitative case studies on the Cochrane student's journal club, the authors evaluate and portray the outcomes in each of its patient-focused, evidence-based learning activities. This study illustrates an exercise centered on the hypothetical case of a patient treated for Plasmodium vivax presenting with a suspected relapse. JF - International Journal of User-Driven Healthcare AU - Chandra, Shivika AU - Shah, Naman K AU - Sriganesh, Vasumathi AD - National Institute of Mental Health and Neurosciences, India Y1 - 2011/10/01/ PY - 2011 DA - 2011 Oct 01 SP - 31 EP - 41 PB - IGI Global, 701 E. Chocolate Ave. Hershey PA 17033 VL - 1 IS - 4 SN - 2156-1818, 2156-1818 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Learning KW - Education KW - Human diseases KW - Plasmodium vivax KW - Medicine KW - Malaria KW - Experts KW - Internet KW - Physical training KW - Public health KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1238109572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+User-Driven+Healthcare&rft.atitle=The+Cochrane+Students+Journal+Club+and+Creating+a+Secondary+Learning+Resource+for+Gathering+and+Appraising+Evidence%3A+An+Example+of+Rational+Use+of+Medicines+to+Prevent+Malaria+Relapse&rft.au=Chandra%2C+Shivika%3BShah%2C+Naman+K%3BSriganesh%2C+Vasumathi&rft.aulast=Chandra&rft.aufirst=Shivika&rft.date=2011-10-01&rft.volume=1&rft.issue=4&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+User-Driven+Healthcare&rft.issn=21561818&rft_id=info:doi/10.4018%2Fijudh.2011100103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-12-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Human diseases; Education; Experts; Malaria; Medicine; Public health; Learning; Internet; Physical training; Plasmodium vivax DO - http://dx.doi.org/10.4018/ijudh.2011100103 ER - TY - JOUR T1 - Giving Care to Men and Women with Mental Illness AN - 1037877409; 201205912 AB - Caregivers are a largely understudied, unsung population who shoulder many of the social and psychological costs of mental illness. This study examines the load of caregiving during symptomatic and stabilised phases of the mentally ill and the various ways in which family members adapt themselves to give care. Drawing its data from 200 families with mental illness in Andhra Pradesh and Karnataka, the study diffuses the notion of care as physical, medical, psychological and social. The article focuses on how the gender of the affected person affects caregiving and underlines the indispensability of the family. Used to giving credit for any improvement to doctors and medicines, the study records the incredulous gratitude of caregivers at being acknowledged for the work they do, providing a boost to the morale of tired, unacknowledged caregivers. [Reprinted by permission of Sage Publications Ltd., copyright holder.] JF - Indian Journal of Gender Studies AU - Janardhana, N AU - Shravya, R AU - Naidu, D M AU - Saraswathy, L AU - Seshan, Valli AD - Psychiatric Social Work, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 405 EP - 424 PB - Sage Publications, New Delhi India VL - 18 IS - 3 SN - 0971-5215, 0971-5215 KW - Caregivers caring for the mentally ill gender and caregiving KW - Caregivers KW - Family KW - Medicine KW - Physicians KW - Mental Illness KW - Sex KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1037877409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+Journal+of+Gender+Studies&rft.atitle=Giving+Care+to+Men+and+Women+with+Mental+Illness&rft.au=Janardhana%2C+N%3BShravya%2C+R%3BNaidu%2C+D+M%3BSaraswathy%2C+L%3BSeshan%2C+Valli&rft.aulast=Janardhana&rft.aufirst=N&rft.date=2011-10-01&rft.volume=18&rft.issue=3&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Indian+Journal+of+Gender+Studies&rft.issn=09715215&rft_id=info:doi/10.1177%2F097152151101800306 LA - English DB - Social Services Abstracts N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-09-28 N1 - CODEN - IJGSF4 N1 - SubjectsTermNotLitGenreText - Caregivers; Family; Mental Illness; Physicians; Sex; Medicine DO - http://dx.doi.org/10.1177/097152151101800306 ER - TY - JOUR T1 - A 400-year record of black carbon flux in the Xisha Archipelago, South China Sea and its implication AN - 1037241022; 2012-078026 AB - We reconstructed the first long-term ( nearly equal 400 years) records of black carbon (BC) deposition flux from three ornithogenic sediment profiles, which were collected from three remote, isolated islets of the Xisha archipelago, South China Sea. The significant correlations between black carbon, organic matter and excess (super 210) Pb suggested that black carbon was mainly derived from atmospheric deposition, and further enriched by plant-derived organic matter in sediments. During the past 400 years, the BC flux remained relatively low before the onset of 20th century; it started to increase from approximately 1900 AD, and peaked around the 1970s. In the recent 30 years, the BC flux seemed to display decreasing trend, very likely due to the change of energy structure and development of pollution control techniques. In comparison with marginal sea regions that are greatly impacted by anthropogenic activities, these pristine Xisha islands were not significantly influenced by black carbon of anthropogenic origin. JF - Marine Pollution Bulletin AU - Liu, Xiaodong AU - Xu, Liqinag AU - Sun, Liguang AU - Liu, Fei AU - Wang, Yuhong AU - Yan, Hong AU - Liu, Yi AU - Luo, Yuhan AU - Huang, Jing Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 2205 EP - 2212 PB - Elsevier, Oxford VL - 62 IS - 10 SN - 0025-326X, 0025-326X KW - Far East KW - isotopes KW - Xisha Islands KW - lead KW - environmental effects KW - cores KW - West Pacific KW - Ra-226 KW - radioactive isotopes KW - cesium KW - black carbon KW - total organic carbon KW - sediments KW - absolute age KW - Northwest Pacific KW - Asia KW - South China Sea KW - China KW - alkaline earth metals KW - radium KW - human activity KW - alkali metals KW - pollution KW - organic compounds KW - Cs-137 KW - North Pacific KW - metals KW - Pacific Ocean KW - Pb-210 KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1037241022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Pollution+Bulletin&rft.atitle=A+400-year+record+of+black+carbon+flux+in+the+Xisha+Archipelago%2C+South+China+Sea+and+its+implication&rft.au=Liu%2C+Xiaodong%3BXu%2C+Liqinag%3BSun%2C+Liguang%3BLiu%2C+Fei%3BWang%2C+Yuhong%3BYan%2C+Hong%3BLiu%2C+Yi%3BLuo%2C+Yuhan%3BHuang%2C+Jing&rft.aulast=Liu&rft.aufirst=Xiaodong&rft.date=2011-10-01&rft.volume=62&rft.issue=10&rft.spage=2205&rft.isbn=&rft.btitle=&rft.title=Marine+Pollution+Bulletin&rft.issn=0025326X&rft_id=info:doi/10.1016%2Fj.marpolbul.2011.06.027 L2 - http://www.sciencedirect.com/science/journal/0025326X LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2012-01-01 N1 - Number of references - 52 N1 - Document feature - illus. incl. 1 table, sketch map N1 - Last updated - 2012-08-31 N1 - CODEN - MPNBAZ N1 - SubjectsTermNotLitGenreText - absolute age; alkali metals; alkaline earth metals; Asia; black carbon; cesium; China; cores; Cs-137; environmental effects; Far East; human activity; isotopes; lead; metals; North Pacific; Northwest Pacific; organic compounds; Pacific Ocean; Pb-210; pollution; Ra-226; radioactive isotopes; radium; sediments; South China Sea; total organic carbon; West Pacific; Xisha Islands DO - http://dx.doi.org/10.1016/j.marpolbul.2011.06.027 ER - TY - JOUR T1 - Understanding Patterns of Health Communication in Families at Risk for Hereditary Nonpolyposis Colorectal Cancer: Examining the Effect of Conclusive Versus Indeterminate Genetic Test Results AN - 1030903819; 201220308 AB - In families meeting criteria for hereditary nonpolyposis colorectal cancer (HNPCC), genetic testing may or may not identify a mutation. Communication about genetic testing and risk in families with identified HNPCC mutations is associated with individual and relational factors. Similar communication patterns would be expected in families with similar clinical and pathological characteristics, but without an identified HNPCC mutation; however, previous studies have not included such families. Social network analysis was used to compare communication networks and associated individual and relational factors in families with and without identified HNPCC mutations. Respondents from families without identified mutations communicated about genetic counseling and testing and risk for HNPCC with a significantly smaller proportion of network members, compared to respondents from mutation-positive families. Members of families without identified mutations were also more likely to share thoughts about risk for HNPCC with network members whose advice they take, compared to members of families with known mutations. These findings extend our knowledge of communication in families at risk of HNPCC to include the many families in which a causative mutation has not yet been identified. Differences in the breadth of communication about genetics and risk for HNPCC, and the possibility that members of families without identified mutations may seek advice from those with whom they communicate about risk, provide new avenues for future research. Understanding existing communication patterns could help improve education and counseling processes, and facilitate the development of interventions designed to assist in family discussions of risk. Adapted from the source document. JF - Health Communication AU - Ersig, Anne L AU - Hadley, Donald W AU - Koehly, Laura M AD - College of Nursing, University of Iowa, National Human Genome Research Institute, National Institute of Nursing Research, National Institutes of Health Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 587 EP - 594 PB - Taylor & Francis Group, Philadelphia PA VL - 26 IS - 7 SN - 1041-0236, 1041-0236 KW - Social networks KW - Colorectal cancer KW - Genetic screening KW - Health information KW - Communication style KW - At risk KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1030903819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Communication&rft.atitle=Understanding+Patterns+of+Health+Communication+in+Families+at+Risk+for+Hereditary+Nonpolyposis+Colorectal+Cancer%3A+Examining+the+Effect+of+Conclusive+Versus+Indeterminate+Genetic+Test+Results&rft.au=Ersig%2C+Anne+L%3BHadley%2C+Donald+W%3BKoehly%2C+Laura+M&rft.aulast=Ersig&rft.aufirst=Anne&rft.date=2011-10-01&rft.volume=26&rft.issue=7&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=Health+Communication&rft.issn=10410236&rft_id=info:doi/10.1080%2F10410236.2011.558338 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-08-01 N1 - Last updated - 2016-09-27 N1 - CODEN - HECOER N1 - SubjectsTermNotLitGenreText - Genetic screening; At risk; Colorectal cancer; Communication style; Social networks; Health information DO - http://dx.doi.org/10.1080/10410236.2011.558338 ER - TY - JOUR T1 - Trait dissociation and the subjective affective, motivational, and phenomenological experience of self-defining memories AN - 1024211450; 4310912 AB - The present research reports 2 studies that examine the relation between nonpathological trait dissociation and the subjective affect, motivation, and phenomenology of self-defining memories. In Study 1 (N=293), participants retrieved and rated the emotional and motivational experience of a general and a positive and negative achievement-related memory. Study 2 (N=449) extended these ratings to relationship-related memories and the phenomenological experience of the memory. Dissociation was associated with incongruent affect in valenced memories (e.g., positive affect in a negative memory) and memories that were visually incoherent and saturated with power motivation, hubristic pride, and shame, regardless of valence or domain. The present findings demonstrate that autobiographical memories, which integrate emotional, motivational, and phenomenological components, reflect the emotional and motivational processes inherent to dissociation. Adapted from the source document. Reprinted by permission of Blackwell Publishers JF - Journal of personality AU - Sutin, Angelina R AU - Stockdale, Gary D AD - National Institute on Aging Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 939 EP - 964 VL - 79 IS - 5 SN - 0022-3506, 0022-3506 KW - Sociology KW - Pride KW - Subjectivity KW - Emotions KW - Memory KW - Autobiography KW - Motivation KW - Personality traits KW - Self KW - Phenomenology KW - Honour and shame UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1024211450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality&rft.atitle=Trait+dissociation+and+the+subjective+affective%2C+motivational%2C+and+phenomenological+experience+of+self-defining+memories&rft.au=Sutin%2C+Angelina+R%3BStockdale%2C+Gary+D&rft.aulast=Sutin&rft.aufirst=Angelina&rft.date=2011-10-01&rft.volume=79&rft.issue=5&rft.spage=939&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality&rft.issn=00223506&rft_id=info:doi/10.1111%2Fj.1467-6494.2010.00708.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4196; 8322; 12347; 9478 9485 9486; 7930; 11442 6191; 1414 1604 7464; 10129; 5976; 9429 9416 2153 DO - http://dx.doi.org/10.1111/j.1467-6494.2010.00708.x ER - TY - JOUR T1 - Cognitive behavior therapy in medication non-responders with obsessive-compulsive disorder: A prospective 1-year follow-up study AN - 1023091247; 201212466 AB - Evidence of efficacy of cognitive behavior therapy (CBT) in obsessive-compulsive disorder (OCD) non-responsive to multiple trials of serotonin reuptake inhibitors (SRI) is limited. We examined the efficacy of CBT in 31 adult patients with DSM-IV OCD who were non-responders to at least two SRI trials. They received 20-25 sessions of CBT over 3-month duration. The primary outcome measure was "response" to treatment [Clinical Global Impressions-Improvement score 1 or 2 and =35% reduction in Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) severity score]. Patients were assessed at baseline, post-treatment and at 3-, 6- and 12-month follow-up. Twenty-six (84%) patients completed treatment and number of responders at post-treatment, 3-, 6- and 12-month follow-up were 23 (74%), 20 (64%), 20 (64%) and 19 (61%) respectively. Quality of homework compliance and baseline Y-BOCS severity predicted remission (Y-BOCS < 16) to CBT. CBT is useful in OCD non-responsive to multiple trials of SRI. [Copyright Elsevier B.V.] JF - Journal of Anxiety Disorders AU - Anand, Nitin AU - Sudhir, Paulomi M AU - Math, Suresh Bada AU - Thennarasu, K AU - Reddy, Y C Janardhan AD - Department of Clinical Psychology, National Institute of Mental Health & Neuro Sciences, India Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 939 EP - 945 PB - Elsevier Ltd, The Netherlands VL - 25 IS - 7 SN - 0887-6185, 0887-6185 KW - Obsessive-compulsive disorder KW - Cognitive-behavior therapy KW - SRI non-response KW - Cognitive behaviour therapy KW - Severity KW - Efficacy KW - Compliance KW - Remission KW - Obsessive-Compulsive neuroses KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023091247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Anxiety+Disorders&rft.atitle=Cognitive+behavior+therapy+in+medication+non-responders+with+obsessive-compulsive+disorder%3A+A+prospective+1-year+follow-up+study&rft.au=Anand%2C+Nitin%3BSudhir%2C+Paulomi+M%3BMath%2C+Suresh+Bada%3BThennarasu%2C+K%3BReddy%2C+Y+C+Janardhan&rft.aulast=Anand&rft.aufirst=Nitin&rft.date=2011-10-01&rft.volume=25&rft.issue=7&rft.spage=939&rft.isbn=&rft.btitle=&rft.title=Journal+of+Anxiety+Disorders&rft.issn=08876185&rft_id=info:doi/10.1016%2Fj.janxdis.2011.05.007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Cognitive behaviour therapy; Obsessive-Compulsive neuroses; Severity; Efficacy; Compliance; Remission DO - http://dx.doi.org/10.1016/j.janxdis.2011.05.007 ER - TY - JOUR T1 - Criteria for Authorship in Bioethics AN - 1023035743; 2011-232448 AB - Multiple authorship is becoming increasingly common in bioethics research. There are well-established criteria for authorship in empirical bioethics research but not for conceptual research. It is important to develop criteria for authorship in conceptual publications to prevent undeserved authorship and uphold standards of fairness and accountability. This article explores the issue of multiple authorship in bioethics and develops criteria for determining who should be an author on a conceptual publication in bioethics. Authorship in conceptual research should be based on contributing substantially to: (1) identifying a topic, problem, or issue to study; (2) reviewing and interpreting the relevant literature; (3) formulating, analyzing, and evaluating arguments that support one or more theses; (4) responding to objections and counterarguments; and (5) drafting the manuscript and approving the final version. Authors of conceptual publications should participate substantially in at least two of areas (1)-(5). Adapted from the source document. JF - The American Journal of Bioethics AU - Resnik, David B AU - Master, Zubin AD - National Institute of Environmental Health Sciences Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 17 EP - 21 PB - Taylor & Francis, Philadelphia PA VL - 11 IS - 10 SN - 1526-5161, 1526-5161 KW - Culture and religion - Literature KW - Law and ethics - Ethics KW - accountability authorship guidelines bioethics conceptual publications fairness multiple authorship KW - Authorship KW - Bioethics KW - Standards KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023035743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Bioethics&rft.atitle=Criteria+for+Authorship+in+Bioethics&rft.au=Resnik%2C+David+B%3BMaster%2C+Zubin&rft.aulast=Resnik&rft.aufirst=David&rft.date=2011-10-01&rft.volume=11&rft.issue=10&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Bioethics&rft.issn=15265161&rft_id=info:doi/10.1080%2F15265161.2011.603795 LA - English DB - PAIS Index N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Authorship; Bioethics; Standards DO - http://dx.doi.org/10.1080/15265161.2011.603795 ER - TY - JOUR T1 - Helicobacter pylori and autoimmune diseases AN - 1020855945; 15995116 AB - Helicobacter pylori (H. pylori) is a widely prevalent microbe, with between 50 and 80% of the population infected worldwide. Clinically, infection with H. pylori is commonly associated with peptic ulcer disease, but many of those infected remain asymptomatic. H. pylori has evolved a number of means to affect the host immune response and has been implicated in many diseases mitigated by immune dysregulation, such as immune thrombocytopenic purpura (ITP), atrophic gastritis, and mucosa associated lymphoid tissue (MALT) lymphoma. Autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and Sjogren's syndrome, are the result of a dysregulated host immune system which targets otherwise healthy tissues. The exact etiology of autoimmune diseases is unclear, but it has long been suggested that exposure to certain environmental agents, such as viral and bacterial infection or chemical exposures, in genetically susceptible individuals may be the catalyst for the initiation of autoimmune processes. Because of its prevalence and ability to affect human immune function, many researchers have hypothesized that H. pylori might contribute to the development of autoimmune diseases. In this article, we review the available literature regarding the role of chronic H. pylori infection in various autoimmune disease states.Original Abstract: Oral Diseases (2011) 17, 621-627 JF - Oral Diseases AU - Hasni, S AU - Ippolito, A AU - Illei, G G AD - National Institute of Arthritis and Musculoskeletal and Skin Diseases Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 621 EP - 627 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 17 IS - 7 SN - 1354-523X, 1354-523X KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Helicobacter pylori KW - Autoimmune diseases KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020855945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oral+Diseases&rft.atitle=Helicobacter+pylori+and+autoimmune+diseases&rft.au=Hasni%2C+S%3BIppolito%2C+A%3BIllei%2C+G+G&rft.aulast=Hasni&rft.aufirst=S&rft.date=2011-10-01&rft.volume=17&rft.issue=7&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Oral+Diseases&rft.issn=1354523X&rft_id=info:doi/10.1111%2Fj.1601-0825.2011.01796.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Document feature - figure 0 N1 - Last updated - 2014-03-20 N1 - SubjectsTermNotLitGenreText - Autoimmune diseases; Helicobacter pylori DO - http://dx.doi.org/10.1111/j.1601-0825.2011.01796.x ER - TY - JOUR T1 - Unpacking the Blockers: Understanding Perceptions and Social Constraints of Health Communication in Hereditary Breast Ovarian Cancer (HBOC) Susceptibility Families AN - 1018378131; 201211580 AB - Family communication is essential for accurate cancer risk assessment and counseling; family blockers play a role in this communication process. This qualitative analysis of social exchanges is an extension of earlier work characterizing those who are perceived by study participants as health information gatherers, disseminators, and blockers within families with Hereditary Breast and Ovarian Cancer (HBOC) susceptibility. Eighty-nine women, ages 23-56 years, enrolled in a Breast Imaging Study (BIS) and participated in a sub-study utilizing a social assessment tool known as the Colored Ecological Genetic Relational Map (CEGRM). Purposive sampling ensured that participants varied according to numbers of participating family members e.g., ranging from 1 to 6. Eighty-nine women from 42 families (1-8 relatives/family) participated. They collectively designated 65 blockers, both male and female. Situational factors, beliefs, attitudes and cultural traditions, privacy and protectiveness comprised perceived reasons for blocking intra-family health communications. Longitudinal data collected over 4 years showed families where blocking behavior was universally recognized and stable over time, as well as other families where blocking was less consistent. Self-blocking was observed among a significant minority of participating women. Blocking of health communications among family members with HBOC was variable, complex, and multifaceted. The reasons for blocking were heterogeneous; duration of the blocking appeared to depend on the reasons for blocking. Blocking often seemed to involve bi-directional feedback loops, in keeping with Lepore's Social Constraints and Modulation Theory. Privacy and protectiveness predominated as explanations for long-term blocking. Adapted from the source document. JF - Journal of Genetic Counseling AU - Peters, June A AU - Kenen, Regina AU - Hoskins, Lindsey M AU - Koehly, Laura M AU - Graubard, Barry AU - Loud, Jennifer T AU - Greene, Mark H AD - Clinical Genetics Branch (CGB), Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), 6120 Executive Blvd, Rockville, MD, 20852, USA petersju@mail.nih.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 450 EP - 464 PB - Springer Science+Business Media, New York NY VL - 20 IS - 5 SN - 1059-7700, 1059-7700 KW - Ovarian cancer KW - Blocking KW - Women KW - Health KW - Relatives KW - Susceptibility KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018378131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Genetic+Counseling&rft.atitle=Unpacking+the+Blockers%3A+Understanding+Perceptions+and+Social+Constraints+of+Health+Communication+in+Hereditary+Breast+Ovarian+Cancer+%28HBOC%29+Susceptibility+Families&rft.au=Peters%2C+June+A%3BKenen%2C+Regina%3BHoskins%2C+Lindsey+M%3BKoehly%2C+Laura+M%3BGraubard%2C+Barry%3BLoud%2C+Jennifer+T%3BGreene%2C+Mark+H&rft.aulast=Peters&rft.aufirst=June&rft.date=2011-10-01&rft.volume=20&rft.issue=5&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=Journal+of+Genetic+Counseling&rft.issn=10597700&rft_id=info:doi/10.1007%2Fs10897-011-9370-0 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JGCOET N1 - SubjectsTermNotLitGenreText - Blocking; Relatives; Women; Ovarian cancer; Health; Susceptibility DO - http://dx.doi.org/10.1007/s10897-011-9370-0 ER - TY - JOUR T1 - Seeing Standards: A Visualization of the Metadata Universe AN - 1018335007; 201205911 AB - Seeing Standards (http://www.dlib.indiana.edu/~jenlrile/metadatamap/) is a visualization of metadata standards developed by Jenn Riley, Metadata Librarian at the Indiana University Digital Library Program. It is intended to "assist planners with the selection and implementation of metadata standards" through a visualization of an astounding 105 standards from AACR2 to the Art and Architecture Thesaurus, from Dublin Core to DTD, MODS, ONIX, SKOS, VRA Core, Z39.50 and an number in between. Adapted from the source document. JF - Technical Services Quarterly AU - Landesman, Betty AD - National Institutes of Health Library, Bethesda, MD Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 459 EP - 460 PB - Taylor & Francis, Philadelphia PA VL - 28 IS - 4 SN - 0731-7131, 0731-7131 KW - Web sites KW - Visualization KW - Standards KW - Metadata KW - article KW - 12.11: CATALOGUING AND INDEXING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018335007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Services+Quarterly&rft.atitle=Seeing+Standards%3A+A+Visualization+of+the+Metadata+Universe&rft.au=Landesman%2C+Betty&rft.aulast=Landesman&rft.aufirst=Betty&rft.date=2011-10-01&rft.volume=28&rft.issue=4&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Technical+Services+Quarterly&rft.issn=07317131&rft_id=info:doi/10.1080%2F07317131.2011.598072 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Standards; Visualization; Metadata; Web sites DO - http://dx.doi.org/10.1080/07317131.2011.598072 ER - TY - JOUR T1 - Identification and removal of proteins that co-purify with infectious prion protein improves the analysis of its secondary structure AN - 1017979477; 16717026 AB - Prion diseases are neurodegenerative disorders associated with the accumulation of an abnormal isoform of the mammalian prion protein (PrP). Fourier transform infrared spectroscopy (FTIR) has previously been used to show that the conformation of aggregated, infectious PrP (PrPSc) varies between prion strains and these unique conformations may determine strain-specific disease phenotypes. However, the relative amounts of -helix, Delta *b-sheet and other secondary structures have not always been consistent between studies, suggesting that other proteins might be confounding the analysis of PrPSc secondary structure. We have used FTIR and LC-MS/MS to analyze enriched PrPSc from mouse and hamster prion strains both before and after the removal of protein contaminants that commonly co-purify with PrPSc. Our data show that non-PrP proteins do contribute to absorbances that have been associated with -helical, loop, turn and Delta *b-sheet structures attributed to PrPSc. The major contaminant, the -helical protein ferritin, absorbs strongly at 1652cm-1 in the FTIR spectrum associated with PrPSc. However, even the removal of more than 99% of the ferritin from PrPSc did not completely abolish absorbance at 1652cm-1. Our results show that contaminating proteins alter the FTIR spectrum attributed to PrPSc and suggest that the -helical, loop/turn and Delta *b-sheet secondary structure that remains following their removal are derived from PrPSc itself. JF - Proteomics AU - Moore, Roger A AU - Timmes, Andrew G AU - Wilmarth, Phillip A AU - Safronetz, David AU - Priola, Suzette A AD - Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Laboratory of Persistent Viral Diseases, National Institutes of Health, Hamilton, MT, USA, rmoore@niaid.nih.gov Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 3853 EP - 3865 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 11 IS - 19 SN - 1615-9861, 1615-9861 KW - CSA Neurosciences Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Protein structure KW - Neurodegenerative diseases KW - Data processing KW - I.R. spectroscopy KW - Secondary structure KW - Prion protein KW - Ferritin KW - proteomics KW - Absorbance KW - Contaminants KW - N3 11007:Neurobiology KW - W 30960:Bioinformatics & Computer Applications KW - V 22380:Prions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017979477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics&rft.atitle=Identification+and+removal+of+proteins+that+co-purify+with+infectious+prion+protein+improves+the+analysis+of+its+secondary+structure&rft.au=Moore%2C+Roger+A%3BTimmes%2C+Andrew+G%3BWilmarth%2C+Phillip+A%3BSafronetz%2C+David%3BPriola%2C+Suzette+A&rft.aulast=Moore&rft.aufirst=Roger&rft.date=2011-10-01&rft.volume=11&rft.issue=19&rft.spage=3853&rft.isbn=&rft.btitle=&rft.title=Proteomics&rft.issn=16159861&rft_id=info:doi/10.1002%2Fpmic.201100253 L2 - http://onlinelibrary.wiley.com/doi/10.1002/pmic.201100253/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Protein structure; Neurodegenerative diseases; Data processing; I.R. spectroscopy; Secondary structure; Prion protein; Ferritin; Absorbance; proteomics; Contaminants DO - http://dx.doi.org/10.1002/pmic.201100253 ER - TY - JOUR T1 - Language Use and Adherence to Multiple Cancer Preventive Health Behaviors Among Hispanics AN - 1010709034; 201209186 AB - Hispanics have lower cancer mortality rates than non-Hispanic Whites and Blacks, despite demographic profiles previously associated with higher cancer mortality. Differences in adherence to multiple cancer-preventive behaviors by acculturation may offer one explanation for this "Hispanic paradox," but the relationship is not well understood. We examined this relationship using the 2000 National Health Interview Survey, which provides cross-sectional data on a nationally representative sample of US Hispanics. Multinomial logistic regression models estimated relationships between language use (a measure of acculturation) and patterns of adherence, by gender, to multiple cancer-preventive health behaviors using adherence scores. Hispanics had greater odds of adherence to multiple behaviors compared to Non-Hispanics (OR = 2.76 [2.27, 3.36]). Hispanics with greater English language use had lower odds of adherence (OR = 0.45 [0.29, 0.69]). Women were more adherent than men (P < 0.01) and their language use was associated with patterns of behavioral adherence more so than among men. Differences by gender and language use were identified in patterns of adherence to behavioral recommendations among the Hispanic population. Greater English language use was negatively associated with tobacco, alcohol, fruit and vegetable recommendation adherence but not with exercise. Study findings support evidence behaviors occur in combination and contributes to understanding of the role of language use in patterns of behavioral adherence. Adapted from the source document. JF - Journal of Immigrant and Minority Health AU - Oh, April AU - Dodd, Kevin AU - Ballard-Barbash, Rachel AU - Perna, Frank M AU - Berrigan, David AD - National Cancer Institute, Division of Cancer Control and Prevention, Behavioral Research Program, Health Promotion Research Branch, 6130 Executive Blvd, Room 4087B, MSC 7335, Rockville, MD, 20852-7335, USA ohay@mail.nih.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 849 EP - 859 PB - Springer, Dordrecht The Netherlands VL - 13 IS - 5 SN - 1557-1912, 1557-1912 KW - Healthy food KW - Acculturation KW - Hispanic people KW - Adherence KW - Gender differences KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010709034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immigrant+and+Minority+Health&rft.atitle=Language+Use+and+Adherence+to+Multiple+Cancer+Preventive+Health+Behaviors+Among+Hispanics&rft.au=Oh%2C+April%3BDodd%2C+Kevin%3BBallard-Barbash%2C+Rachel%3BPerna%2C+Frank+M%3BBerrigan%2C+David&rft.aulast=Oh&rft.aufirst=April&rft.date=2011-10-01&rft.volume=13&rft.issue=5&rft.spage=849&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immigrant+and+Minority+Health&rft.issn=15571912&rft_id=info:doi/10.1007%2Fs10903-011-9456-7 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Adherence; Hispanic people; Cancer; Healthy food; Acculturation; Gender differences DO - http://dx.doi.org/10.1007/s10903-011-9456-7 ER - TY - JOUR T1 - Polymorphic triple beta-sheet structures contribute to amide hydrogen/deuterium (H/D) exchange protection in the Alzheimer amyloid beta42 peptide. AN - 894815383; 21832091 AB - Characterization of the polymorphic structural range of Aβ oligomers is important to the understanding of the mechanisms of toxicity. Yet for highly polymorphic ensembles, experimental structural elucidation is difficult. Here, we use a combination of NMR solvent protection experiments and computational structural screening to identify major species in the amyloid conformational ensemble. We examined the polymorphic pentamer and fibril seeds of Aβ42 and its mutants and compared the theoretical backbone amide protection obtained from simulations with experimental hydrogen/deuterium (H/D) exchange protection ratio. We observed that highly flexible pentamers do not share structural similarities with fibril seed oligomers, except the turn regions. We found that a novel amyloid structural motif of a triple β-sheet, with the N-terminal residues interacting with the core (Lys(17)-Glu(22)) β-sheet region, correlates with H/D exchange protection. The triple β-sheet Aβ42 oligomer has a minimal exposure of hydrophobic residues and is further stabilized by the E22Q (Dutch) mutation in Alzheimer disease. The experimental H/D exchange solvent protection ratio implies that triple β-sheet fibrils and globulomers could coexist in the Aβ42 ensemble, pointing to a broad heterogeneous aggregate population. Our results suggest that an approach that combines computational modeling with NMR protection data can be a useful strategy for obtaining clues to the preferred conformational species of the assemblies in solution and help in alleviating experimental difficulties and consequently possible errors in the exchange data for Aβ42 fibrils. JF - The Journal of biological chemistry AU - Ma, Buyong AU - Nussinov, Ruth AD - SAIC-Frederick, Inc, Center for Cancer Research Nanobiology Program, NCI, National Institutes of Health, Frederick, Maryland 21702, USA. mabuyong@mail.nih.gov Y1 - 2011/09/30/ PY - 2011 DA - 2011 Sep 30 SP - 34244 EP - 34253 VL - 286 IS - 39 KW - Amyloid KW - 0 KW - Amyloid beta-Peptides KW - Peptide Fragments KW - amyloid beta-protein (1-42) KW - Index Medicus KW - Protein Structure, Secondary KW - Alzheimer Disease -- genetics KW - Humans KW - Alzheimer Disease -- metabolism KW - Deuterium Exchange Measurement KW - Peptide Fragments -- metabolism KW - Amyloid beta-Peptides -- genetics KW - Peptide Fragments -- chemistry KW - Peptide Fragments -- genetics KW - Amyloid beta-Peptides -- metabolism KW - Amyloid beta-Peptides -- chemistry KW - Amyloid -- chemistry KW - Models, Chemical KW - Amyloid -- genetics KW - Mutation KW - Amyloid -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/894815383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Polymorphic+triple+beta-sheet+structures+contribute+to+amide+hydrogen%2Fdeuterium+%28H%2FD%29+exchange+protection+in+the+Alzheimer+amyloid+beta42+peptide.&rft.au=Ma%2C+Buyong%3BNussinov%2C+Ruth&rft.aulast=Ma&rft.aufirst=Buyong&rft.date=2011-09-30&rft.volume=286&rft.issue=39&rft.spage=34244&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M111.241141 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-22 N1 - Date created - 2011-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Neurosci. 2001 Jun;13(11):2015-24 [11422442] J Mol Biol. 2011 Jan 21;405(3):851-62 [21108949] Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14126-31 [12391326] Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16742-7 [12481027] Lancet. 2003 Jun 7;361(9373):1957-8 [12801742] J Biol Chem. 2003 Jun 27;278(26):23221-6 [12695513] J Comput Chem. 2003 Aug;24(11):1348-56 [12827676] Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14790-5 [14657385] Biochemistry. 2005 Mar 22;44(11):4434-41 [15766273] J Comput Chem. 2005 Dec;26(16):1781-802 [16222654] Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17342-7 [16293696] Biochemistry. 2006 Jan 17;45(2):498-512 [16401079] J Biol Chem. 2006 Jan 6;281(1):477-83 [16215229] Biochemistry. 2006 May 2;45(17):5503-16 [16634632] Curr Opin Chem Biol. 2006 Oct;10(5):445-52 [16935548] J Biol Chem. 2007 Feb 16;282(7):4916-23 [17170111] Angew Chem Int Ed Engl. 2007;46(8):1246-52 [17203498] Biochem J. 2007 May 15;404(1):63-70 [17280549] Biophys J. 2007 Jun 1;92(11):4064-77 [17307823] Biochim Biophys Acta. 2007 Aug;1768(8):1886-99 [17499210] Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5099-104 [18375754] Neurobiol Dis. 2008 May;30(2):212-20 [18353662] Anal Biochem. 2009 Feb 15;385(2):374-6 [19027706] Angew Chem Int Ed Engl. 2009;48(11):1981-6 [19035593] Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4653-8 [19264960] Proc Natl Acad Sci U S A. 2009 May 5;106(18):7443-8 [19376973] Biochemistry. 2009 Mar 10;48(9):1870-7 [19216516] Biochemistry. 2009 Jul 7;48(26):6072-84 [19358576] Biophys J. 2009 Aug 5;97(3):912-21 [19651050] Nat Struct Mol Biol. 2009 Sep;16(9):973-8 [19684598] Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19813-8 [19843697] Protein Sci. 2010 Feb;19(2):349-56 [19998407] J Biol Chem. 2010 Feb 26;285(9):6071-9 [20018889] Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3487-92 [20133726] Biophys J. 2010 Jan 20;98(2):282-96 [20338850] Nat Struct Mol Biol. 2010 May;17(5):561-7 [20383142] Chemistry. 2010 May 10;16(18):5492-9 [20358555] Chem Rev. 2010 Aug 11;110(8):4820-38 [20402519] Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14128-33 [20660780] Biochemistry. 2010 Oct 19;49(41):8967-77 [20731379] J Biol Chem. 2010 Nov 19;285(47):37102-10 [20847046] J Mol Biol. 2010 Nov 26;404(2):337-52 [20887731] Protein Sci. 2002 Jul;11(7):1639-47 [12070316] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M111.241141 ER - TY - JOUR T1 - Pubertal delay in male nonhuman primates (Macaca mulatta) treated with methylphenidate. AN - 894816366; 21930929 AB - Juvenile male rhesus monkeys treated with methylphenidate hydrochloride (MPH) to evaluate genetic and behavioral toxicity were observed after 14 mo of treatment to have delayed pubertal progression with impaired testicular descent and reduced testicular volume. Further evaluation of animals dosed orally twice a day with (i) 0.5 mL/kg of vehicle (n = 10), (ii) 0.15 mg/kg of MPH increased to 2.5 mg/kg (low dose, n = 10), or (iii) 1.5 mg/kg of MPH increased to 12.5 mg/kg (high dose, n = 10) for a total of 40 mo revealed that testicular volume was significantly reduced (P < 0.05) at months 15 to 19 and month 27. Testicular descent was significantly delayed (P < 0.05) in the high-dose group. Significantly lower serum testosterone levels were detected in both the low- (P = 0.0017) and high-dose (P = 0.0011) animals through month 33 of treatment. Although serum inhibin B levels were increased overall in low-dose animals (P = 0.0328), differences between groups disappeared by the end of the study. Our findings indicate that MPH administration, beginning before puberty, and which produced clinically relevant blood levels of the drug, impaired pubertal testicular development until ∼5 y of age. It was not possible to resolve whether MPH delayed the initiation of the onset of puberty or reduced the early tempo of the developmental process. Regardless, deficits in testicular volume and hormone secretion disappeared over the 40-mo observation period, suggesting that the impact of MPH on puberty is not permanent. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Mattison, Donald R AU - Plant, Tony M AU - Lin, Hui-Min AU - Chen, Hung-Chia AU - Chen, James J AU - Twaddle, Nathan C AU - Doerge, Daniel AU - Slikker, William AU - Patton, Ralph E AU - Hotchkiss, Charlotte E AU - Callicott, Ralph J AU - Schrader, Steven M AU - Turner, Terry W AU - Kesner, James S AU - Vitiello, Benedetto AU - Petibone, Dayton M AU - Morris, Suzanne M AD - Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, The Eunice Kennedy Shriver National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. mattisod@mail.nih.gov Y1 - 2011/09/27/ PY - 2011 DA - 2011 Sep 27 SP - 16301 EP - 16306 VL - 108 IS - 39 KW - Central Nervous System Stimulants KW - 0 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Testosterone KW - 3XMK78S47O KW - Index Medicus KW - Testis -- growth & development KW - Animals KW - Testis -- drug effects KW - Testosterone -- blood KW - Macaca mulatta KW - Male KW - Sexual Maturation -- drug effects KW - Central Nervous System Stimulants -- pharmacology KW - Methylphenidate -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/894816366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Pubertal+delay+in+male+nonhuman+primates+%28Macaca+mulatta%29+treated+with+methylphenidate.&rft.au=Mattison%2C+Donald+R%3BPlant%2C+Tony+M%3BLin%2C+Hui-Min%3BChen%2C+Hung-Chia%3BChen%2C+James+J%3BTwaddle%2C+Nathan+C%3BDoerge%2C+Daniel%3BSlikker%2C+William%3BPatton%2C+Ralph+E%3BHotchkiss%2C+Charlotte+E%3BCallicott%2C+Ralph+J%3BSchrader%2C+Steven+M%3BTurner%2C+Terry+W%3BKesner%2C+James+S%3BVitiello%2C+Benedetto%3BPetibone%2C+Dayton+M%3BMorris%2C+Suzanne+M&rft.aulast=Mattison&rft.aufirst=Donald&rft.date=2011-09-27&rft.volume=108&rft.issue=39&rft.spage=16301&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.1102187108 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-21 N1 - Date created - 2011-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Endocrinol Metab. 2000 Sep;85(9):3239-44 [10999815] J Mol Med (Berl). 2001;79(1):8-20 [11327106] Mol Cell Endocrinol. 2001 Jun 30;180(1-2):93-101 [11451577] Endocrinology. 2003 Apr;144(4):1175-85 [12639898] Biol Reprod. 1981 Sep;25(2):244-52 [6796135] Endocr Rev. 1986 Feb;7(1):75-88 [3082617] Endocrinology. 1998 Jun;139(6):2774-83 [9607784] J Clin Endocrinol Metab. 1998 Jun;83(6):1835-41 [9626105] J Androl. 1999 May-Jun;20(3):430-4 [10386823] Ann N Y Acad Sci. 2005 Dec;1061:149-62 [16467264] Brain Res Bull. 2006 Oct 16;70(4-6):422-9 [17027778] Ann N Y Acad Sci. 2006 Aug;1074:52-73 [17105903] Child Dev. 2007 May-Jun;78(3):927-37 [17517013] J Am Acad Child Adolesc Psychiatry. 2007 Aug;46(8):1015-27 [17667480] Biol Reprod. 2008 Jul;79(1):93-9 [18367678] Mutat Res. 2009 Feb 19;673(1):59-66 [19135169] Ann Intern Med. 2010 Jan 19;152(2):93-100 [20083828] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.1102187108 ER - TY - JOUR T1 - Meat-cooking mutagens and risk of renal cell carcinoma AN - 1008840399; 16451020 AB - Background: High-temperature cooked meat contains two families of carcinogens, heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs). Given the kidneys' role in metabolism and urinary excretion of these compounds, we investigated meat-derived mutagens, as well as meat intake and cooking methods, in a population-based case-control study conducted in metropolitan Detroit and Chicago. Methods: Newly diagnosed, histologically confirmed adenocarcinoma of the renal parenchyma (renal cell carcinoma (RCC)) cases (n=1192) were frequency matched on age, sex, and race to controls (n=1175). The interviewer-administered Diet History Questionnaire (DHQ) included queries for meat-cooking methods and doneness with photographic aids. Levels of meat mutagens were estimated using the DHQ in conjunction with the CHARRED database. Results: The risk of RCC increased with intake of barbecued meat (P sub(trend)=0.04) and the PAH, benzo(a)pyrene (BaP) (multivariable-adjusted odds ratio and 95% confidence interval, highest vs lowest quartile: 1.50 (1.14, 1.95), P sub(trend)=0.001). With increasing BaP intake, the risk of RCC was more than twofold in African Americans and current smokers (P sub(interaction)<0.05). We found no association for HCAs or overall meat intake. Conclusion: BaP intake, a PAH in barbecued meat, was positively associated with RCC. These biologically plausible findings advocate further epidemiological investigation into dietary intake of BaP and risk of RCC. JF - British Journal of Cancer AU - Daniel, C R AU - Schwartz, K L AU - Colt, J S AU - Dong, L M AU - Ruterbusch, J J AU - Purdue, M P AU - Cross, A J AU - Rothman, N AU - Davis, F G AU - Wacholder, S AU - Graubard, B I AU - Chow, W H AU - Sinha, R AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Rockville, MD 20852, USA Y1 - 2011/09/27/ PY - 2011 DA - 2011 Sep 27 SP - 1096 EP - 1104 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 105 IS - 7 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - USA, Illinois, Chicago KW - Diets KW - Mutagens KW - USA, Michigan, Detroit KW - Urine KW - meat KW - Kidney KW - cooking KW - Excretion KW - Cancer KW - Metabolism KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1008840399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Meat-cooking+mutagens+and+risk+of+renal+cell+carcinoma&rft.au=Daniel%2C+C+R%3BSchwartz%2C+K+L%3BColt%2C+J+S%3BDong%2C+L+M%3BRuterbusch%2C+J+J%3BPurdue%2C+M+P%3BCross%2C+A+J%3BRothman%2C+N%3BDavis%2C+F+G%3BWacholder%2C+S%3BGraubard%2C+B+I%3BChow%2C+W+H%3BSinha%2C+R&rft.aulast=Daniel&rft.aufirst=C&rft.date=2011-09-27&rft.volume=105&rft.issue=7&rft.spage=1096&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fbjc.2011.343 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Diets; Mutagens; Urine; meat; Kidney; Excretion; cooking; Metabolism; Cancer; USA, Illinois, Chicago; USA, Michigan, Detroit DO - http://dx.doi.org/10.1038/bjc.2011.343 ER - TY - CPAPER T1 - Regulation of Innate Host Factors by Mycobacterium avium Perpetuates Survival in Human Macrophages T2 - 2011 Annual Meeting of The Society for Leukocyte Biology (SLB 2011) AN - 1313024915; 6061152 JF - 2011 Annual Meeting of The Society for Leukocyte Biology (SLB 2011) AU - Vazquez, Nancy Y1 - 2011/09/22/ PY - 2011 DA - 2011 Sep 22 KW - survival KW - Macrophages KW - Cell survival KW - Mycobacterium avium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313024915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+The+Society+for+Leukocyte+Biology+%28SLB+2011%29&rft.atitle=Regulation+of+Innate+Host+Factors+by+Mycobacterium+avium+Perpetuates+Survival+in+Human+Macrophages&rft.au=Vazquez%2C+Nancy&rft.aulast=Vazquez&rft.aufirst=Nancy&rft.date=2011-09-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+The+Society+for+Leukocyte+Biology+%28SLB+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://leukocytebiology.org/PDFS/25/258e8f80-a8cd-4763-a3fd-b2dfdb866b2a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Structural Insights into the Activation and Inhibition of Histo-Aspartic Protease from Plasmodium falciparum AN - 926895568; 16063853 AB - Histo-aspartic protease (HAP) from Plasmodium falciparum is a promising target for the development of novel antimalarial drugs. The sequence of HAP is highly similar to those of pepsin-like aspartic proteases, but one of the two catalytic aspartates, Asp32, is replaced with histidine. Crystal structures of the truncated zymogen of HAP and of the complex of the mature enzyme with inhibitor KNI-10395 have been determined at 2.1 and 2.5 A resolution, respectively. As in other proplasmepsins, the propeptide of the zymogen interacts with the C-terminal domain of the enzyme, forcing the N- and C-terminal domains apart, thereby separating His32 and Asp215 and preventing formation of the mature active site. In the inhibitor complex, the enzyme forms a tight domain-swapped dimer, not previously seen in any aspartic proteases. The inhibitor is found in an unprecedented conformation resembling the letter U, stabilized by two intramolecular hydrogen bonds. Surprisingly, the location and conformation of the inhibitor are similar to those of the fragment of helix 2 comprising residues 34p--38p in the prosegments of the zymogens of gastric aspartic proteases; a corresponding helix assumes a vastly different orientation in proplasmepsins. Each inhibitor molecule is in contact with two molecules of HAP, interacting with the carboxylate group of the catalytic Asp215 of one HAP protomer through a water molecule, while also making a direct hydrogen bond to Glu278A' of the other protomer. A comparison of the shifts in the positions of the catalytic residues in the inhibitor complex presented here with those published previously gives further hints regarding the enzymatic mechanism of HAP. JF - Biochemistry (Washington) AU - Bhaumik, Prasenjit AU - Xiao, Huogen AU - Hidaka?, Koushi AU - Gustchina, Alla AU - Kiso?, Yoshiaki AU - Yada, Rickey Y AU - Wlodawer, Alexander AD - Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland 21702, United States Y1 - 2011/09/19/ PY - 2011 DA - 2011 Sep 19 SP - 8862 EP - 8879 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 United States VL - 50 IS - 41 SN - 0006-2960, 0006-2960 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Enzymes KW - Drug development KW - Plasmodium falciparum KW - Proenzymes KW - USA, Washington KW - aspartic endopeptidase KW - Hydrogen bonding KW - Histidine KW - Crystal structure KW - Inhibitors KW - Drugs KW - Conformation KW - K 03340:Effects of Physical & Chemical Factors KW - Q1 08625:Non-edible products KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926895568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Structural+Insights+into+the+Activation+and+Inhibition+of+Histo-Aspartic+Protease+from+Plasmodium+falciparum&rft.au=Bhaumik%2C+Prasenjit%3BXiao%2C+Huogen%3BHidaka%3F%2C+Koushi%3BGustchina%2C+Alla%3BKiso%3F%2C+Yoshiaki%3BYada%2C+Rickey+Y%3BWlodawer%2C+Alexander&rft.aulast=Bhaumik&rft.aufirst=Prasenjit&rft.date=2011-09-19&rft.volume=50&rft.issue=41&rft.spage=8862&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi201118z L2 - http://pubs.acs.org/doi/abs/10.1021/bi201118z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Parasites; Inhibitors; Drugs; aspartic endopeptidase; Hydrogen bonding; Histidine; Crystal structure; Enzymes; Drug development; Proenzymes; Conformation; Plasmodium falciparum; USA, Washington DO - http://dx.doi.org/10.1021/bi201118z ER - TY - CPAPER T1 - Bacterial Infections in Immunodeficiency: Still Emerging After All These Years T2 - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AN - 1313095525; 6110678 JF - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AU - Holland, Steven Y1 - 2011/09/17/ PY - 2011 DA - 2011 Sep 17 KW - Infection KW - Immunodeficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313095525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.atitle=Bacterial+Infections+in+Immunodeficiency%3A+Still+Emerging+After+All+These+Years&rft.au=Holland%2C+Steven&rft.aulast=Holland&rft.aufirst=Steven&rft.date=2011-09-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icaac.org/images/icaac2011_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Nontuberculous Mycobacteria: An Emerging Pathogen in CF T2 - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AN - 1313021961; 6111518 JF - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AU - Olivier, Kenneth Y1 - 2011/09/17/ PY - 2011 DA - 2011 Sep 17 KW - Pathogens UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313021961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.atitle=Nontuberculous+Mycobacteria%3A+An+Emerging+Pathogen+in+CF&rft.au=Olivier%2C+Kenneth&rft.aulast=Olivier&rft.aufirst=Kenneth&rft.date=2011-09-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icaac.org/images/icaac2011_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Regulation by Small RNAs in Bacteria: Expanding Frontiers AN - 1762380649; 15744580 JF - Molecular Cell AU - Storz, Gisela AU - Vogel, Joerg AU - Wassarman, Karen M Y1 - 2011/09/16/ PY - 2011 DA - 2011 Sep 16 SP - 880 EP - 891 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 United States VL - 43 IS - 6 SN - 1097-2765, 1097-2765 KW - Microbiology Abstracts B: Bacteriology KW - Bacteria KW - J 02490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762380649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cell&rft.atitle=Regulation+by+Small+RNAs+in+Bacteria%3A+Expanding+Frontiers&rft.au=Storz%2C+Gisela%3BVogel%2C+Joerg%3BWassarman%2C+Karen+M&rft.aulast=Storz&rft.aufirst=Gisela&rft.date=2011-09-16&rft.volume=43&rft.issue=6&rft.spage=880&rft.isbn=&rft.btitle=&rft.title=Molecular+Cell&rft.issn=10972765&rft_id=info:doi/10.1016%2Fj.molcel.2011.08.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Bacteria DO - http://dx.doi.org/10.1016/j.molcel.2011.08.022 ER - TY - JOUR T1 - CAM-CM: a signal deconvolution tool for in vivo dynamic contrast-enhanced imaging of complex tissues AN - 915484152; 16101662 AB - Summary: In vivo dynamic contrast-enhanced imaging tools provide non-invasive methods for analyzing various functional changes associated with disease initiation, progression and responses to therapy. The quantitative application of these tools has been hindered by its inability to accurately resolve and characterize targeted tissues due to spatially mixed tissue heterogeneity. Convex Analysis of Mixtures - Compartment Modeling (CAM-CM) signal deconvolution tool has been developed to automatically identify pure-volume pixels located at the corners of the clustered pixel time series scatter simplex and subsequently estimate tissue-specific pharmacokinetic parameters. CAM-CM can dissect complex tissues into regions with differential tracer kinetics at pixel-wise resolution and provide a systems biology tool for defining imaging signatures predictive of phenotypes. JF - Bioinformatics AU - Chen, Li AU - Chan, Tsung-Han AU - Choyke, Peter L AU - Hillman, Elizabeth MC AU - Chi, Chong-Yung AU - Bhujwalla, Zaver M AU - Wang, Ge AU - Wang, Sean S AU - Szabo, Zsolt AU - Wang, Yue AD - super(1)Bradley Department of Electrical and Computer Engineering, Virginia Tech, Arlington, VA 22203, USA, super(2)Department of Electrical Engineering, National Tsing Hua University, Taiwan, ROC 30013, super(3)Molecular Imaging Program, National Cancer Institute, NIH, Bethesda, MD 20892, super(4)Department of Biomedical Engineering and Radiology, Columbia University, New York, NY 10027, super(5)Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, super(6)School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24061 and super(7)Science, Mathematics, Computer Science House, Poolesville High School, Poolesville, MD 20837, USA, Y1 - 2011/09/15/ PY - 2011 DA - 2011 Sep 15 SP - 2607 EP - 2609 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 27 IS - 18 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Tracers KW - Data processing KW - Kinetics KW - Bioinformatics KW - imaging KW - Internet KW - Pharmacokinetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/915484152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=CAM-CM%3A+a+signal+deconvolution+tool+for+in+vivo+dynamic+contrast-enhanced+imaging+of+complex+tissues&rft.au=Chen%2C+Li%3BChan%2C+Tsung-Han%3BChoyke%2C+Peter+L%3BHillman%2C+Elizabeth+MC%3BChi%2C+Chong-Yung%3BBhujwalla%2C+Zaver+M%3BWang%2C+Ge%3BWang%2C+Sean+S%3BSzabo%2C+Zsolt%3BWang%2C+Yue&rft.aulast=Chen&rft.aufirst=Li&rft.date=2011-09-15&rft.volume=27&rft.issue=18&rft.spage=2607&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtr436 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Tracers; Data processing; Kinetics; Bioinformatics; imaging; Pharmacokinetics; Internet DO - http://dx.doi.org/10.1093/bioinformatics/btr436 ER - TY - JOUR T1 - Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1[alpha] inhibitors AN - 907167479; 15700287 AB - Quinazolin-4-one 1 was identified as an inhibitor of the HIF-1[alpha] transcriptional factor from a high-throughput screen. HIF-1[alpha] up-regulation is common in many cancer cells. In this Letter, we describe an efficient one-pot sequential reaction for the synthesis of quinazolin-4-one 1 analogues. The structure-activity relationship (SAR) study led to the 5-fold more potent analogue, 16. JF - Bioorganic and Medicinal Chemistry Letters AU - Huang, Wenwei AU - Huang, Ruili AU - Attene-Ramos, Matias S AU - Sakamuru, Srilatha AU - Englund, Erika E AU - Inglese, James AU - Austin, Christopher P AU - Xia, Menghang Y1 - 2011/09/15/ PY - 2011 DA - 2011 Sep 15 SP - 5239 EP - 5243 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 21 IS - 18 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - Structure-activity relationships KW - Cancer KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907167479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Synthesis+and+evaluation+of+quinazolin-4-ones+as+hypoxia-inducible+factor-1%5Balpha%5D+inhibitors&rft.au=Huang%2C+Wenwei%3BHuang%2C+Ruili%3BAttene-Ramos%2C+Matias+S%3BSakamuru%2C+Srilatha%3BEnglund%2C+Erika+E%3BInglese%2C+James%3BAustin%2C+Christopher+P%3BXia%2C+Menghang&rft.aulast=Huang&rft.aufirst=Wenwei&rft.date=2011-09-15&rft.volume=21&rft.issue=18&rft.spage=5239&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2011.07.043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Structure-activity relationships; Cancer DO - http://dx.doi.org/10.1016/j.bmcl.2011.07.043 ER - TY - JOUR T1 - Automated volumetric growth plate measurement using magnetic resonance imaging for monitoring skeletal toxicity in children treated on investigational drug trials. AN - 892945229; 21807634 AB - Targeted anticancer agents have been reported to have side effects on the skeletal system such as thickening of the epiphyseal growth plate in preclinical models of juvenile, but not mature, animals. Careful evaluation of skeletal toxicity in the clinical development of targeted therapies for children is required. We validated a novel method to measure the growth plate volume using MRI. A semiautomated method of volumetric growth plate measurement was developed on the basis of the differences of pixel intensity of the growth plate from surrounding bone on T(1) sagittal MRI. Two observers measured the femoral growth plate volume and thickness on three different days using 20 pediatric knee MRIs obtained at the NIH. Five subjects had two knee MRIs obtained on the same day to evaluate intrasubject reproducibility. Volumetric analysis showed low intraobserver variability, with the coefficient of variation for the two observers ranging from 0.2% to 6.1%. Interobserver correlation was 0.99, and good concordance was shown with a mean volume difference of -1.8 mm(3). One-dimensional measurements had poorer intra and interobserver consistency. No statistically significant differences in volumetric measurements were observed between the two scans done on the same day in five subjects (P = 0.5). MRI volumetric growth plate measurement is a reproducible and sensitive method to evaluate meaningful growth plate volume changes over time. This tool, along with close monitoring of height and laboratory evaluations for bone metabolism, may be used to evaluate potential bone and growth toxicities of children enrolled in trials of investigational drugs. ©2011 AACR. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Kim, AeRang AU - Dombi, Eva AU - Solomon, Jeffrey AU - Fox, Elizabeth AU - Balis, Frank M AU - Widemann, Brigitte C AD - Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA. aekim@cnmc.org Y1 - 2011/09/15/ PY - 2011 DA - 2011 Sep 15 SP - 5982 EP - 5990 VL - 17 IS - 18 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Drugs, Investigational KW - Index Medicus KW - Sensitivity and Specificity KW - Reproducibility of Results KW - Humans KW - Child KW - Observer Variation KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Magnetic Resonance Imaging KW - Drug Monitoring KW - Antineoplastic Agents -- toxicity KW - Drugs, Investigational -- toxicity KW - Growth Plate -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/892945229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Automated+volumetric+growth+plate+measurement+using+magnetic+resonance+imaging+for+monitoring+skeletal+toxicity+in+children+treated+on+investigational+drug+trials.&rft.au=Kim%2C+AeRang%3BDombi%2C+Eva%3BSolomon%2C+Jeffrey%3BFox%2C+Elizabeth%3BBalis%2C+Frank+M%3BWidemann%2C+Brigitte+C&rft.aulast=Kim&rft.aufirst=AeRang&rft.date=2011-09-15&rft.volume=17&rft.issue=18&rft.spage=5982&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-10-2259 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-17 N1 - Date created - 2011-09-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurology. 2009 Oct 20;73(16):1273-9 [19841379] Clin Pharmacol Ther. 2009 Feb;85(2):127-9 [19151636] Blood. 2010 Jan 28;115(4):766-74 [19890095] J Bone Miner Res. 2010 Aug;25(8):1759-70 [20225261] J Clin Oncol. 2010 Nov 1;28(31):4762-8 [20921456] J Clin Oncol. 2010 Dec 10;28(35):5174-81 [21060028] Bone. 2000 Oct;27(4):495-501 [11033444] Trends Cardiovasc Med. 2000 Jul;10(5):223-8 [11282299] J Am Acad Dermatol. 2001 Nov;45(5):S176-82 [11606950] Comput Med Imaging Graph. 2004 Jul;28(5):257-65 [15249071] Cell Biol Int Rep. 1992 Feb;16(2):133-44 [1551145] Nat Med. 1999 Jun;5(6):623-8 [10371499] Cancer Res. 2005 May 15;65(10):4389-400 [15899831] Toxicol Pathol. 2006;34(2):131-47 [16537292] Comp Med. 2006 Dec;56(6):502-11 [17219781] J Clin Oncol. 2008 Jan 20;26(3):399-405 [18202416] Cancer Cell. 2008 Mar;13(3):249-60 [18328428] Oncologist. 2008 Jun;13(6):679-89 [18586923] Pediatr Blood Cancer. 2008 Sep;51(3):418-20 [18493993] Pediatr Blood Cancer. 2009 Feb;52(2):304-5; author reply 306 [18819126] Leukemia. 2009 Nov;23(11):2155-9 [19626049] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-10-2259 ER - TY - JOUR T1 - Separation of mutational and transcriptional enhancers in Ig genes. AN - 888337239; 21844395 AB - Secondary Ig gene diversification relies on activation-induced cytidine deaminase (AID) to create U:G mismatches that are subsequently fixed by mutagenic repair pathways. AID activity is focused to Ig loci by cis-regulatory DNA sequences named targeting elements. In this study, we show that in contrast to prevailing thought in the field, the targeting elements in the chicken IGL locus are distinct from classical transcriptional enhancers. These mutational enhancer elements (MEEs) are required over and above transcription to recruit AID-mediated mutagenesis to Ig loci. We identified a small 222-bp fragment in the chicken IGL locus that enhances mutagenesis without boosting transcription, and this sequence represents a key component of an MEE. Lastly, MEEs are evolutionarily conserved among birds, both in sequence and function, and contain several highly conserved sequence modules that are likely involved in recruiting trans-acting targeting factors. We propose that MEEs represent a novel class of cis-regulatory elements for which the function is to control genomic integrity. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Kothapalli, Naga Rama AU - Collura, Kaitlin M AU - Norton, Darrell D AU - Fugmann, Sebastian D AD - Molecular Immunology Unit, Laboratory of Molecular Biology and Immunology, National Institute on Aging/National Institutes of Health, Biomedical Research Center, Baltimore, MD 21224, USA. Y1 - 2011/09/15/ PY - 2011 DA - 2011 Sep 15 SP - 3247 EP - 3255 VL - 187 IS - 6 KW - Immunoglobulin Light Chains KW - 0 KW - AICDA (activation-induced cytidine deaminase) KW - EC 3.5.4.- KW - Cytidine Deaminase KW - EC 3.5.4.5 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Chickens KW - Base Sequence KW - Blotting, Northern KW - Conserved Sequence KW - Cells, Cultured KW - Blotting, Southern KW - Cytidine Deaminase -- immunology KW - Molecular Sequence Data KW - Cytidine Deaminase -- genetics KW - Mutation KW - DNA Mismatch Repair -- genetics KW - Genes, Immunoglobulin -- genetics KW - Enhancer Elements, Genetic -- genetics KW - Immunoglobulin Light Chains -- genetics KW - DNA Mismatch Repair -- immunology KW - Enhancer Elements, Genetic -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888337239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Separation+of+mutational+and+transcriptional+enhancers+in+Ig+genes.&rft.au=Kothapalli%2C+Naga+Rama%3BCollura%2C+Kaitlin+M%3BNorton%2C+Darrell+D%3BFugmann%2C+Sebastian+D&rft.aulast=Kothapalli&rft.aufirst=Naga&rft.date=2011-09-15&rft.volume=187&rft.issue=6&rft.spage=3247&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/10.4049%2Fjimmunol.1101568 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-09 N1 - Date created - 2011-09-08 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - HQ414233; GENBANK; JF693631 N1 - SuppNotes - Cited By: Genome Res. 2000 Apr;10(4):577-86 [10779500] Cell. 2010 Oct 1;143(1):122-33 [20887897] Cell. 2000 Sep 1;102(5):565-75 [11007475] Science. 2002 Feb 15;295(5558):1301-6 [11847344] Immunity. 2003 Aug;19(2):235-42 [12932357] BMC Biotechnol. 2001;1:7 [11591226] Proc Natl Acad Sci U S A. 2004 May 11;101(19):7352-6 [15123833] Nucleic Acids Res. 1995 Jun 11;23(11):1997-2005 [7596829] Science. 1998 Jun 12;280(5370):1750-2 [9624052] Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11816-21 [9751748] Genome Res. 2005 Jan;15(1):184-94 [15590941] Curr Opin Immunol. 2006 Apr;18(2):164-74 [16464563] Nat Rev Immunol. 2006 Aug;6(8):573-83 [16868548] Adv Immunol. 2007;94:109-25 [17560273] Annu Rev Biochem. 2007;76:1-22 [17328676] Nat Genet. 2008 Jan;40(1):108-12 [18066064] J Immunol. 2008 Feb 15;180(4):2019-23 [18250404] Nature. 2008 Feb 14;451(7180):841-5 [18273020] Mol Immunol. 2008 Apr;45(7):2062-8 [18023479] Mol Biol Evol. 2008 Jun;25(6):1148-57 [18343891] Cell. 2008 Dec 12;135(6):1028-38 [19070574] J Immunol. 2009 Jan 1;182(1):408-15 [19109172] PLoS Genet. 2009 Jan;5(1):e1000332 [19132090] Mol Immunol. 2009 Oct;46(16):3283-91 [19699530] J Exp Med. 2009 Nov 23;206(12):2613-23 [19887393] Nat Cell Biol. 2010 Feb;12(2):111-8 [20098417] J Exp Med. 2010 Feb 15;207(2):405-15 [20100870] Nat Immunol. 2010 Sep;11(9):820-6 [20657597] Cell. 2000 Sep 1;102(5):553-63 [11007474] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4049/jimmunol.1101568 ER - TY - JOUR T1 - Arsenic transformation predisposes human skin keratinocytes to UV-induced DNA damage yet enhances their survival apparently by diminishing oxidant response. AN - 885908939; 21820459 AB - Inorganic arsenic and UV, both human skin carcinogens, may act together as skin co-carcinogens. We find human skin keratinocytes (HaCaT cells) are malignantly transformed by low-level arsenite (100nM, 30weeks; termed As-TM cells) and with transformation concurrently undergo full adaptation to arsenic toxicity involving reduced apoptosis and oxidative stress response to high arsenite concentrations. Oxidative DNA damage (ODD) is a possible mechanism in arsenic carcinogenesis and a hallmark of UV-induced skin cancer. In the current work, inorganic arsenite exposure (100nM) did not induce ODD during the 30weeks required for malignant transformation. Although acute UV-treatment (UVA, 25J/cm(2)) increased ODD in passage-matched control cells, once transformed by arsenic to As-TM cells, acute UV actually further increased ODD (>50%). Despite enhanced ODD, As-TM cells were resistant to UV-induced apoptosis. The response of apoptotic factors and oxidative stress genes was strongly mitigated in As-TM cells after UV exposure including increased Bcl2/Bax ratio and reduced Caspase-3, Nrf2, and Keap1 expression. Several Nrf2-related genes (HO-1, GCLs, SOD) showed diminished responses in As-TM cells after UV exposure consistent with reduced oxidant stress response. UV-exposed As-TM cells showed increased expression of cyclin D1 (proliferation gene) and decreased p16 (tumor suppressor). UV exposure enhanced the malignant phenotype of As-TM cells. Thus, the co-carcinogenicity between UV and arsenic in skin cancer might involve adaptation to chronic arsenic exposure generally mitigating the oxidative stress response, allowing apoptotic by-pass after UV and enhanced cell survival even in the face of increased UV-induced oxidative stress and increased ODD. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Sun, Yang AU - Kojima, Chikara AU - Chignell, Colin AU - Mason, Ronald AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, and National Toxicology Laboratories, National Toxicology Program, the National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2011/09/15/ PY - 2011 DA - 2011 Sep 15 SP - 242 EP - 250 VL - 255 IS - 3 KW - Arsenites KW - 0 KW - Oxidants KW - arsenite KW - N5509X556J KW - Index Medicus KW - Skin -- metabolism KW - Apoptosis -- physiology KW - Humans KW - Apoptosis -- radiation effects KW - Oxidative Stress -- radiation effects KW - Oxidative Stress -- physiology KW - Skin -- radiation effects KW - Skin -- drug effects KW - Cell Survival -- drug effects KW - Apoptosis -- drug effects KW - Ultraviolet Rays -- adverse effects KW - Oxidative Stress -- drug effects KW - Cell Survival -- radiation effects KW - Cell Line KW - Cell Survival -- physiology KW - Keratinocytes -- radiation effects KW - DNA Damage -- physiology KW - Arsenites -- pharmacology KW - Oxidants -- antagonists & inhibitors KW - Keratinocytes -- drug effects KW - Arsenites -- toxicity KW - Oxidants -- metabolism KW - Keratinocytes -- metabolism KW - DNA Damage -- radiation effects KW - DNA Damage -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885908939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Arsenic+transformation+predisposes+human+skin+keratinocytes+to+UV-induced+DNA+damage+yet+enhances+their+survival+apparently+by+diminishing+oxidant+response.&rft.au=Sun%2C+Yang%3BKojima%2C+Chikara%3BChignell%2C+Colin%3BMason%2C+Ronald%3BWaalkes%2C+Michael+P&rft.aulast=Sun&rft.aufirst=Yang&rft.date=2011-09-15&rft.volume=255&rft.issue=3&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2011.07.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-27 N1 - Date created - 2011-08-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Photochem Photobiol. 1999 Oct;70(4):380-90 [10546543] J Natl Cancer Inst. 2010 May 5;102(9):638-49 [20339138] Eur J Cancer. 1999 Dec;35(14):2003-9 [10711242] J Biol Chem. 2000 May 26;275(21):16023-9 [10821856] Methods Enzymol. 2000;319:302-9 [10907522] Toxicol Appl Pharmacol. 2001 May 1;172(3):249-61 [11312654] Toxicol Sci. 2001 Jun;61(2):314-20 [11353140] Int J Biochem Cell Biol. 2001 Aug;33(8):735-53 [11404179] Toxicol Appl Pharmacol. 2001 Oct 1;176(1):64-71 [11578149] Toxicol Lett. 2002 Jul 7;133(1):1-16 [12076506] Mol Cell Biochem. 2002 May-Jun;234-235(1-2):301-8 [12162448] Environ Health Perspect. 2002 Oct;110 Suppl 5:749-52 [12426125] Environ Health Perspect. 2002 Oct;110 Suppl 5:761-6 [12426128] J Biol Chem. 2003 Mar 7;278(10):8058-64 [12502708] J Occup Environ Med. 2003 Mar;45(3):241-8 [12661181] Cancer Lett. 2003 Mar 31;192(2):151-60 [12668279] Toxicology. 2003 Jul 15;189(1-2):21-39 [12821280] Indian J Exp Biol. 2002 Nov;40(11):1213-32 [13677623] Exp Cell Res. 2003 Nov 1;290(2):234-45 [14567983] Mutat Res. 2003 Dec 10;533(1-2):37-65 [14643412] Mol Cell Biochem. 2004 Jan;255(1-2):57-66 [14971646] Mol Cell Biochem. 2004 Jan;255(1-2):67-78 [14971647] J Natl Cancer Inst. 2004 Mar 17;96(6):466-74 [15026472] Environ Health Perspect. 2004 Apr;112(5):599-603 [15064167] Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4954-9 [15041750] Toxicol Appl Pharmacol. 2004 Aug 1;198(3):253-67 [15276404] Toxicol Appl Pharmacol. 2004 Aug 1;198(3):291-6 [15276408] J Cell Biol. 1988 Mar;106(3):761-71 [2450098] Br J Dermatol. 1991 Jun;124(6):555-9 [2064938] Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2965-9 [8385353] Free Radic Biol Med. 1994 Jan;16(1):29-33 [8299992] Proc Natl Acad Sci U S A. 1994 May 10;91(10):4293-7 [8183903] J Immunol Methods. 1995 Jul 17;184(1):39-51 [7622868] Carcinogenesis. 1997 Jun;18(6):1215-23 [9214605] Mutat Res. 1997 Jun;386(3):209-18 [9219559] Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8103-7 [9653147] Am J Pathol. 1998 Dec;153(6):1775-85 [9846968] IARC Monogr Eval Carcinog Risks Hum. 2004;84:269-477 [15645578] Int J Cancer. 2005 Aug 10;116(1):20-6 [15756686] Nat Methods. 2006 Feb;3(2):123-7 [16432522] Adv Enzyme Regul. 2006;46:113-40 [16887173] Toxicol Appl Pharmacol. 2006 Nov 1;216(3):407-15 [16876216] J Invest Dermatol. 2007 Jan;127(1):222-32 [16902416] Nat Protoc. 2007;2(3):512-22 [17406615] Toxicol Appl Pharmacol. 2007 Aug 1;222(3):289-97 [17316729] Free Radic Biol Med. 2008 Sep 1;45(5):651-8 [18572023] Cancer Res. 2008 Oct 15;68(20):8278-85 [18922899] Pharmacol Res. 2008 Nov-Dec;58(5-6):262-70 [18838122] Toxicology. 2009 Aug 3;262(2):162-70 [19524636] J Natl Cancer Inst. 2009 Dec 16;101(24):1670-81 [19933942] Cell. 2000 Jan 7;100(1):57-70 [10647931] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2011.07.006 ER - TY - JOUR T1 - Interaction of celecoxib with different anti-cancer drugs is antagonistic in breast but not in other cancer cells. AN - 885903254; 21763710 AB - Celecoxib, an inhibitor of cyclooxygenase-2, is being investigated for enhancement of chemotherapy efficacy in cancer clinical trials. This study investigates the ability of cyclooxygenase-2 inhibitors to sensitize cells from different origins to several chemotherapeutic agents. The effect of the drug's mechanism of action and sequence of administration are also investigated. The sensitivity, cell cycle, apoptosis and DNA damage of five different cancer cell lines (HeLa, HCT116, HepG2, MCF7 and U251) to 5-FU, cisplatin, doxorubicin and etoposide±celecoxib following different incubation schedules were analyzed. We found antagonism between celecoxib and the four drugs in the breast cancer cells MCF7 following all incubation schedules and between celecoxib and doxorubicin in all cell lines except for two combinations in HCT116 cells. Celecoxib with the other three drugs in the remaining four cell lines resulted in variable interactions. Mechanistic investigations revealed that celecoxib exerts different molecular effects in different cells. In some lines, it abrogates the drug-induced G2/M arrest enhancing pre-mature entry into mitosis with damaged DNA thus increasing apoptosis and resulting in synergism. In other cells, it enhances drug-induced G2/M arrest allowing time to repair drug-induced DNA damage before entry into mitosis and decreasing cell death resulting in antagonism. In some synergistic combinations, celecoxib-induced abrogation of G2/M arrest was not associated with apoptosis but permanent arrest in G1 phase. These results, if confirmed in-vivo, indicate that celecoxib is not a suitable chemosensitizer for breast cancer or with doxorubicin for other cancers. Moreover, combination of celecoxib with other drugs should be tailored to the tumor type, drug and administration schedule. Copyright © 2011 Elsevier Inc. All rights reserved. JF - Toxicology and applied pharmacology AU - El-Awady, Raafat A AU - Saleh, Ekram M AU - Ezz, Marwa AU - Elsayed, Abeer M AD - Pharmacology unit, Department of Cancer Biology, National, Cancer Institute, Cairo University, Fom El-Khalig, Cairo, Egypt. relawady@sharjah.ac.ae Y1 - 2011/09/15/ PY - 2011 DA - 2011 Sep 15 SP - 271 EP - 286 VL - 255 IS - 3 KW - Antineoplastic Agents KW - 0 KW - Pyrazoles KW - Sulfonamides KW - Celecoxib KW - JCX84Q7J1L KW - Index Medicus KW - DNA Damage -- physiology KW - Hep G2 Cells KW - Cell Survival -- drug effects KW - HeLa Cells KW - Humans KW - Cell Line, Tumor KW - HCT116 Cells KW - Female KW - Drug Interactions -- physiology KW - Cell Survival -- physiology KW - DNA Damage -- drug effects KW - Sulfonamides -- metabolism KW - Pyrazoles -- metabolism KW - Pyrazoles -- pharmacology KW - Breast Neoplasms -- pathology KW - Sulfonamides -- pharmacology KW - Antineoplastic Agents -- metabolism KW - Breast Neoplasms -- metabolism KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885903254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Interaction+of+celecoxib+with+different+anti-cancer+drugs+is+antagonistic+in+breast+but+not+in+other+cancer+cells.&rft.au=El-Awady%2C+Raafat+A%3BSaleh%2C+Ekram+M%3BEzz%2C+Marwa%3BElsayed%2C+Abeer+M&rft.aulast=El-Awady&rft.aufirst=Raafat&rft.date=2011-09-15&rft.volume=255&rft.issue=3&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2011.06.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-27 N1 - Date created - 2011-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2011.06.019 ER - TY - JOUR T1 - Enhanced long-term fear memory and increased anxiety and depression-like behavior after exposure to an aversive event in mice lacking TIP39 signaling AN - 883020547; 14892770 AB - Exaggerated recall for fear-provoking events leads to abnormal behaviors. We hypothesized that tuberoinfundibular-peptide-of-39-residues (TIP39) modulates fear memory by limiting long-term consequences of aversive experiences. We now show that mice lacking TIP39 signaling display enhanced fear-recall, anxiety and depression-like behavior 2 weeks after a traumatic event. We suggest that TIP39 modulates long-term fear recall and that mice lacking TIP39 or its receptor are tools for investigating fear-related psychopathologies. JF - Behavioural Brain Research AU - Coutellier, Laurence AU - Usdin, Ted B AD - Section on Fundamental Neuroscience, NIMH, National Institutes of Health (NIH), 35 Convent Drive, 20892 Bethesda, MD, USA, usdint@mail.nih.gov Y1 - 2011/09/12/ PY - 2011 DA - 2011 Sep 12 SP - 265 EP - 269 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 222 IS - 1 SN - 0166-4328, 0166-4328 KW - Toxicology Abstracts; Animal Behavior Abstracts; CSA Neurosciences Abstracts KW - Memory KW - Anxiety KW - Fear KW - Psychopathology KW - Y 25090:Emotion and Fear KW - N3 11001:Behavioral and Cognitive Neuroscience KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883020547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+Brain+Research&rft.atitle=Enhanced+long-term+fear+memory+and+increased+anxiety+and+depression-like+behavior+after+exposure+to+an+aversive+event+in+mice+lacking+TIP39+signaling&rft.au=Coutellier%2C+Laurence%3BUsdin%2C+Ted+B&rft.aulast=Coutellier&rft.aufirst=Laurence&rft.date=2011-09-12&rft.volume=222&rft.issue=1&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Behavioural+Brain+Research&rft.issn=01664328&rft_id=info:doi/10.1016%2Fj.bbr.2011.02.043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Memory; Anxiety; Fear; Psychopathology DO - http://dx.doi.org/10.1016/j.bbr.2011.02.043 ER - TY - JOUR T1 - Studies on the effect of column angle in figure-8 centrifugal counter-current chromatography AN - 1266752943; 15591074 AB - The performance of the figure-8 column configuration in centrifugal counter-current chromatography was investigated by changing the angle between the column axis (a line through the central post and the peripheral post on which the figure-8 coil is wound) and the centrifugal force. The first series of experiments was performed using a polar two-phase solvent system composed of 1-butanol-acetic acid-water (4:1:5, v/v) to separate two dipeptide samples, Trp-Tyr and Val-Tyr, at a flow rate of 0.05 ml/min at 1000 rpm. When the column angle was changed from 0 degree (column axis parallel to the centrifugal force) to 45 degree and 45 degree to 90 degree (column axis perpendicular to the centrifugal force), peak resolution (Rs) changed from 1.93 (Sf = 37.8%) to 1.54 (Sf = 30.6%), then to 1.31 (Sf = 40.5%) with the lower mobile phase and from 1.21 (Sf = 38.8%) to 1.10 (Sf = 34.4%), then to 0.99 (Sf = 42.2%) with the upper mobile phase, respectively, where the stationary phase retention, Sf, is given in parentheses. The second series of experiments was similarly performed with a more hydrophobic two-phase solvent system composed of hexane-ethyl acetate-methanol-0.1 M hydrochloric acid (1:1:1:1, v/v) to separate three DNP-amino acids, DNP-glu, DNP- beta -ala and DNP-ala, at a flow rate of 0.05 ml/min at 1000 rpm. When the column angle was altered from 0 degree to 45 degree and 45 degree to 90 degree , Rs changed from 1.77 (1st peak/2nd peak) and 1.52 (2nd peak/3rd peak) (Sf = 27.3%) to 1.24 and 1.02 (Sf = 35.4%), then to 1.69 and 1.49 (Sf = 42.1%) with the lower mobile phase, and from 1.73 and 0.84 (SF = 41.2%) to 1.44 and 0.73 (Sf = 45.6%), then to 1.21 and 0.63 (Sf = 55.6%) with the upper mobile phase, respectively. The performance of figure-8 column at 0 degree and 90 degree was also compared at different flow rates. The results show that Rs was increased with decreased flow rate yielding the highest value at the 0 degree column angle with lower mobile phase. The overall results of our studies indicated that a 0 degree column angle for the figure-8 column enhances the mixing of two phases in the column to improve peak resolution while decreasing the stationary phase retention by interrupting the laminar flow of the mobile phase. JF - Journal of Chromatography A AU - Yang, Yi AU - Gu, Dongyu AU - Aisa, Haji Akber AU - Ito, Yoichiro Y1 - 2011/09/09/ PY - 2011 DA - 2011 Sep 09 SP - 6128 EP - 6134 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1218 IS - 36 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - Centrifugal counter-current chromatography KW - Figure-8 column KW - Angle between column axis and centrifugal force KW - Retention of the stationary phase KW - Resolution KW - Dipeptide KW - DNP-amino acid KW - Laminar Flow KW - Chromatography KW - Chromatographic techniques KW - Solvents KW - Retention KW - Mixing KW - Centrifugal force KW - Performance Evaluation KW - Flow Rates KW - Laminar flow KW - Analytical Methods KW - Acids KW - SW 5010:Network design KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266752943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Studies+on+the+effect+of+column+angle+in+figure-8+centrifugal+counter-current+chromatography&rft.au=Yang%2C+Yi%3BGu%2C+Dongyu%3BAisa%2C+Haji+Akber%3BIto%2C+Yoichiro&rft.aulast=Yang&rft.aufirst=Yi&rft.date=2011-09-09&rft.volume=1218&rft.issue=36&rft.spage=6128&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2010.11.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Centrifugal force; Laminar flow; Chromatographic techniques; Solvents; Performance Evaluation; Laminar Flow; Flow Rates; Chromatography; Analytical Methods; Acids; Retention; Mixing DO - http://dx.doi.org/10.1016/j.chroma.2010.11.014 ER - TY - JOUR T1 - Vortex counter-current chromatography AN - 1266752926; 15591072 AB - A novel counter-current chromatographic system is developed by mounting a vortex column on a type-I coil planet centrifuge. The column is fabricated from a high-density polyethylene disk (16 cm diameter and 5 cm thick) by making multiple holes of various diameters (3-12.5 mm) each arranged in a circle and connected with narrow transfer ducts. The performance of this vortex column is tested with three different two-phase solvent systems with a broad range in hydrophobicity. The results indicated that the smallest diameter column (3 mm diameter, 120 units with 42.8 ml capacity) yielded the best separation with the height equivalent to a theoretical plate of 2 cm compared with 20 cm required by the conventional multilayer coil column of high-speed CCC. By avoiding the use of an Archimedean Screw Force, the system shows a low column pressure which would permit safe operation of a large preparative column without a risk of leakage of solvent and column damage. JF - Journal of Chromatography A AU - Ito, Yoichiro AU - Ma, Zhiyong AU - Clary, Robert AU - Powell, Jimmie AU - Knight, Martha AU - Finn, Thomas M Y1 - 2011/09/09/ PY - 2011 DA - 2011 Sep 09 SP - 6165 EP - 6172 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1218 IS - 36 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - Vortex counter-current chromatography KW - Type-I coil planet centrifuge KW - Cylindrical vortex column KW - Damage KW - Leakage KW - Chromatography KW - Chromatographic techniques KW - Solvents KW - Risk KW - Performance Evaluation KW - Analytical Methods KW - Centrifuges KW - Permits KW - Capacity KW - AQ 00001:Water Resources and Supplies KW - SW 5010:Network design KW - Q5 08521:Mechanical and natural changes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266752926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Vortex+counter-current+chromatography&rft.au=Ito%2C+Yoichiro%3BMa%2C+Zhiyong%3BClary%2C+Robert%3BPowell%2C+Jimmie%3BKnight%2C+Martha%3BFinn%2C+Thomas+M&rft.aulast=Ito&rft.aufirst=Yoichiro&rft.date=2011-09-09&rft.volume=1218&rft.issue=36&rft.spage=6165&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2010.10.058 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Centrifuges; Chromatographic techniques; Solvents; Risk; Damage; Performance Evaluation; Leakage; Chromatography; Analytical Methods; Capacity; Permits DO - http://dx.doi.org/10.1016/j.chroma.2010.10.058 ER - TY - JOUR T1 - Simple, Direct Conjugation of Bacterial O-SP--Core Antigens to Proteins: Development of Cholera Conjugate Vaccines AN - 1776644511; 16063962 AB - Bacterial O-SP--core antigens can be conjugated to proteins in the same, simple way as synthetic, linker-equipped carbohydrates by applying squaric acid chemistry. Introduction of spacers (linkers) to either O-SP--core antigens or protein carriers, which is involved in commonly applied protocols, is not required. The newly developed method described here consists of preparation of a squaric acid monoester derivative of O-SP--core antigen, utilizing the amino group inherent in the core, and reaction of the monoester with the carrier protein. The intermediate monoester can be easily purified; its conjugation can be monitored by SELDI-TOF mass spectrometry and, thus, readily controlled, since the conjugation can be terminated when the desired carbohydrate--protein ratio is reached. Here, we describe production of conjugates containing the O-SP--core antigen of Vibrio cholerae O1, the major cause of cholera, a severe dehydrating diarrheal disease of humans. The resultant products are recognized by convalescent phase sera from patients recovering from cholera in Bangladesh, and anti-O-SP-core-protein responses correlate with plasma antilipopolysaccharide and vibriocidal responses, which are the primary markers of protection from cholera. The results suggest that such conjugates have potential as vaccines for cholera and other bacterial diseases. JF - Bioconjugate Chemistry AU - Xu, Peng AU - Alam, Mohammad Murshid AU - Kalsy, Anuj AU - Charles, Richelle C AU - Calderwood, Stephen B AU - Qadri, Firdausi AU - Ryan, Edward T AU - Kovac, Pavol AD - NIDDK, LBC, National Institutes of Health, 8 Center Drive, Bethesda, Maryland 20892-0815, United States Y1 - 2011/09/08/ PY - 2011 DA - 2011 Sep 08 SP - 2179 EP - 2185 VL - 22 IS - 10 SN - 1043-1802, 1043-1802 KW - Microbiology Abstracts B: Bacteriology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - ISW, Bangladesh KW - Amino groups KW - Conjugation KW - Diarrhea KW - Pathogenic bacteria KW - Bacterial diseases KW - Disease control KW - Spacer KW - Mass spectroscopy KW - Public health KW - Vibrio cholerae KW - Antigens KW - Proteins KW - Cholera KW - Vaccines KW - Carbohydrates KW - Q1 08423:Behaviour KW - J 02400:Human Diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776644511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+Chemistry&rft.atitle=Simple%2C+Direct+Conjugation+of+Bacterial+O-SP--Core+Antigens+to+Proteins%3A+Development+of+Cholera+Conjugate+Vaccines&rft.au=Xu%2C+Peng%3BAlam%2C+Mohammad+Murshid%3BKalsy%2C+Anuj%3BCharles%2C+Richelle+C%3BCalderwood%2C+Stephen+B%3BQadri%2C+Firdausi%3BRyan%2C+Edward+T%3BKovac%2C+Pavol&rft.aulast=Xu&rft.aufirst=Peng&rft.date=2011-09-08&rft.volume=22&rft.issue=10&rft.spage=2179&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+Chemistry&rft.issn=10431802&rft_id=info:doi/10.1021%2Fbc2001984 L2 - http://pubs.acs.org/doi/abs/10.1021/bc2001984 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Conjugation; Antigens; Pathogenic bacteria; Bacterial diseases; Disease control; Proteins; Carbohydrates; Vaccines; Public health; Amino groups; Diarrhea; Spacer; Cholera; Mass spectroscopy; Vibrio cholerae; ISW, Bangladesh DO - http://dx.doi.org/10.1021/bc2001984 ER - TY - JOUR T1 - Personality and obesity across the adult life span AN - 911912117; 4256373 AB - Personality traits contribute to health outcomes, in part through their association with major controllable risk factors, such as obesity. Body weight, in turn, reflects our behaviors and lifestyle and contributes to the way we perceive ourselves and others. In this study, the authors use data from a large (N = 1,988) longitudinal study that spanned more than 50 years to examine how personality traits are associated with multiple measures of adiposity and with fluctuations in body mass index (BMI). Using 14,531 anthropometric assessments, the authors modeled the trajectory of BMI across adulthood and tested whether personality predicted its rate of change. Measured concurrently, participants higher on Neuroticism or Extraversion or lower on Conscientiousness had higher BMI; these associations replicated across body fat, waist, and hip circumference. The strongest association was found for the impulsivity facet: Participants who scored in the top 10% of impulsivity weighed, on average, 11Kg more than those in the bottom 10%. Longitudinally, high Neuroticism and low Conscientiousness, and the facets of these traits related to difficulty with impulse control, were associated with weight fluctuations, measured as the variability in weight over time. Finally, low Agreeableness and impulsivity-related traits predicted a greater increase in BMI across the adult life span. BMI was mostly unrelated to change in personality traits. Personality traits are defined by cognitive, emotional, and behavioral patterns that likely contribute to unhealthy weight and difficulties with weight management. Such associations may elucidate the role of personality traits in disease progression and may help to design more effective interventions. [Copyright The American Psychological Association.] Reprinted by permission of the American Psychological Association JF - Journal of personality and social psychology AU - Sutin, Angelina R AU - Ferrucci, Luigi AU - Zonderman, Alan B AU - Terracciano, Antonio AD - National Institutes of Health Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 579 EP - 592 VL - 101 IS - 3 SN - 0022-3514, 0022-3514 KW - Sociology KW - Obesity KW - Body KW - Neuroses KW - Personality traits KW - Personality KW - Adults KW - Diseases KW - Life styles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911912117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality+and+social+psychology&rft.atitle=Personality+and+obesity+across+the+adult+life+span&rft.au=Sutin%2C+Angelina+R%3BFerrucci%2C+Luigi%3BZonderman%2C+Alan+B%3BTerracciano%2C+Antonio&rft.aulast=Sutin&rft.aufirst=Angelina&rft.date=2011-09-01&rft.volume=101&rft.issue=3&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality+and+social+psychology&rft.issn=00223514&rft_id=info:doi/10.1037%2Fa0024286 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9416 2153; 8823; 1678; 9429 9416 2153; 3617 6220; 8638 7951 6220 7954; 7404; 603 DO - http://dx.doi.org/10.1037/a0024286 ER - TY - JOUR T1 - Antibody Profiling of Borrelia burgdorferi Infection in Horses AN - 911161036; 16063097 AB - Infection with Borrelia burgdorferi is common in horses and ponies from the New England and mid-Atlantic regions of the United States. Here, we evaluated luciferase immunoprecipitation systems (LIPS) for profiling antibody responses against three different antigenic targets for the diagnosis of equine B. burgdorferi infection. LIPS testing of horse serum samples suspected of Lyme infection revealed that approximately 75% of the horse samples (114/159) were seropositive against the synthetic VOVO antigen, comprising repeated immunodominant C6 epitopes as well as OspC immunodominant epitopes. A comparison of VOVO and immunofluorescence assays (IFA) showed that 51% of the samples were positive in both assays (VOVO+/IFA+), 13% were VOVO-/IFA+, 21% were VOVO+/IFA-, and 15% were negative in both. To further understand humoral responses to B. burgdorferi and reconcile the diagnostic differences between IFA and VOVO, two additional B. burgdorferi LIPS tests were performed with DbpA and DbpB. Robust seropositive antibody responses against DbpA and/or DbpB were detected in 98% (79/81) of the VOVO+/IFA+ and 93% (50/54) of the discrepant samples. Additionally, some of the samples negative by both VOVO and IFA showed immunoreactivity against DbpA and/or DbpB. Overall, 94% of the suspected horse samples were seropositive by LIPS, and heat map analysis revealed that seropositive samples often were immunoreactive with at least two of the three antigens. These results suggest that LIPS tests employing multiple recombinant antigens offer a promising approach for the evaluation of antibody responses in Lyme disease. JF - Clinical and Vaccine Immunology AU - Burbelo, Peter D AU - Bren, Kathleen E AU - Ching, Kathryn H AU - Coleman, Adam AU - Yang, Xiuli AU - Kariu, Toru AU - Iadarola, Michael J AU - Pal, Utpal AD - Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, burbelop@nidcr.nih.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1562 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 18 IS - 9 SN - 1556-679X, 1556-679X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Antibodies KW - Borrelia burgdorferi KW - Heat KW - Immunoreactivity KW - Immunoprecipitation KW - Immunofluorescence KW - Infection KW - Epitopes KW - Lyme disease KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911161036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Antibody+Profiling+of+Borrelia+burgdorferi+Infection+in+Horses&rft.au=Burbelo%2C+Peter+D%3BBren%2C+Kathleen+E%3BChing%2C+Kathryn+H%3BColeman%2C+Adam%3BYang%2C+Xiuli%3BKariu%2C+Toru%3BIadarola%2C+Michael+J%3BPal%2C+Utpal&rft.aulast=Burbelo&rft.aufirst=Peter&rft.date=2011-09-01&rft.volume=18&rft.issue=9&rft.spage=1562&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.05123-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Antibodies; Heat; Immunoreactivity; Immunoprecipitation; Immunofluorescence; Infection; Epitopes; Lyme disease; Borrelia burgdorferi DO - http://dx.doi.org/10.1128/CVI.05123-11 ER - TY - JOUR T1 - Structure and function of RapA: A bacterial Swi2/Snf2 protein required for RNA polymerase recycling in transcription AN - 910785740; 15720943 AB - One of the hallmarks of the Swi2/Snf2 family members is their ability to modify the interaction between DNA-binding protein and DNA in controlling gene expression. The studies of Swi2/Snf2 have been mostly focused on their roles in chromatin and/or nucleosome remodeling in eukaryotes. A bacterial Swi2/Snf2 protein named RapA from Escherichia coli is a unique addition to these studies. RapA is an RNA polymerase (RNAP)-associated protein and an ATPase. It binds nucleic acids including RNA and DNA. The ATPase activity of RapA is stimulated by its interaction with RNAP, but not with nucleic acids. RapA and the major sigma factor Ief70 compete for binding to core RNAP. After one transcription cycle in vitro, RNAP is immobilized in an undefined posttranscription/posttermination complex (PTC), thus becoming unavailable for reuse. RapA stimulates RNAP recycling by ATPase-dependent remodeling of PTC, leading to the release of sequestered RNAP, which then becomes available for reuse in another cycle of transcription. Recently, the crystal structure of RapA that is also the first full-length structure for the entire Swi2/Snf2 family was determined. The structure provides a framework for future studies of the mechanism of RNAP recycling in transcription. This article is part of a Special Issue entitled: Snf2/Swi2 ATPase structure and function. JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms AU - Jin, Ding Jun AU - Zhou, Yan Ning AU - Shaw, Gary AU - Ji, Xinhua Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 470 EP - 475 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 1809 IS - 9 SN - 1874-9399, 1874-9399 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - Adenosinetriphosphatase KW - Chromatin KW - Crystal structure KW - Cycle protein KW - DNA-binding protein KW - DNA-directed RNA polymerase KW - Gene expression KW - Nucleosomes KW - Recycling KW - Sigma factor KW - Snf2 protein KW - Structure-function relationships KW - Transcription KW - nucleic acids KW - Escherichia coli KW - J 02310:Genetics & Taxonomy KW - N 14820:DNA Metabolism & Structure KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/910785740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+Biophysica+Acta+-+Gene+Regulatory+Mechanisms&rft.atitle=Structure+and+function+of+RapA%3A+A+bacterial+Swi2%2FSnf2+protein+required+for+RNA+polymerase+recycling+in+transcription&rft.au=Jin%2C+Ding+Jun%3BZhou%2C+Yan+Ning%3BShaw%2C+Gary%3BJi%2C+Xinhua&rft.aulast=Jin&rft.aufirst=Ding&rft.date=2011-09-01&rft.volume=1809&rft.issue=9&rft.spage=470&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+Biophysica+Acta+-+Gene+Regulatory+Mechanisms&rft.issn=18749399&rft_id=info:doi/10.1016%2Fj.bbagrm.2011.03.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-05-18 N1 - SubjectsTermNotLitGenreText - Adenosinetriphosphatase; Cycle protein; Chromatin; DNA-binding protein; Transcription; Recycling; Gene expression; DNA-directed RNA polymerase; Nucleosomes; nucleic acids; Structure-function relationships; Crystal structure; Sigma factor; Snf2 protein; Escherichia coli DO - http://dx.doi.org/10.1016/j.bbagrm.2011.03.003 ER - TY - JOUR T1 - Connecting Contemporary Paradigms to the Social Security Administration's Disability Evaluation Process AN - 908014581; 2011-142317 AB - From 1998 to 2008, the Social Security Administration's (SSA) disability insurance program (DI) applications rose from 1.2 million to 2.3 million and exceeded 3 million in 2009. Given these large and growing numbers, even small changes in processing disability applications may reduce processing time, lower program costs, and improve performance of SSA's disability programs. A literature review examining current conceptual models of disability and SSA's disability evaluation process for adults was conducted. A gap exists between contemporary models of disability and how SSA defines and operationalizes disability. This is complicated by substantial variation in the timing, quantity, and quality of applicant functional information and workplace demands. A focus on impairment marginalizes more comprehensive assessment of function necessary to assess capacity for work. Novel assessment methodologies, such as computer adaptive testing to measure human functioning may hold promise for SSA's data collection methods and disability assessment. Adapted from the source document. JF - Journal of Disability Policy Studies AU - Brandt, Diane E AU - Houtenville, Andrew J AU - Huynh, Minh T AU - Chan, Leighton AU - Rasch, Elizabeth K AD - National Institutes of Health Clinical Research Center, Bethesda, MD, USA brandtdi@cc.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 116 EP - 128 PB - PRO-ED, Austin TX VL - 22 IS - 2 SN - 1044-2073, 1044-2073 KW - Social conditions and policy - Social policy and social development KW - Population groups, population policy, and demographics - Disabled KW - Business and service sector - Personnel management KW - Manufacturing and heavy industry - Industrial management, production, and productivity KW - Business and service sector - Business operations, practices, and workplaces KW - Science and technology policy - Computer science and information technology KW - Economic conditions and policy - Economic theory KW - Population groups, population policy, and demographics - Demography and census KW - Business and service sector - Insurance KW - Health conditions and policy - Health and health policy KW - disability evaluation Social Security Administration impairment functional ability KW - Cost KW - Disability insurance KW - Computers KW - Disabled KW - Adults KW - Performance KW - Workplaces KW - Social policy KW - Social insurance KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/908014581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Disability+Policy+Studies&rft.atitle=Connecting+Contemporary+Paradigms+to+the+Social+Security+Administration%27s+Disability+Evaluation+Process&rft.au=Brandt%2C+Diane+E%3BHoutenville%2C+Andrew+J%3BHuynh%2C+Minh+T%3BChan%2C+Leighton%3BRasch%2C+Elizabeth+K&rft.aulast=Brandt&rft.aufirst=Diane&rft.date=2011-09-01&rft.volume=22&rft.issue=2&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Journal+of+Disability+Policy+Studies&rft.issn=10442073&rft_id=info:doi/10.1177%2F1044207310396509 LA - English DB - PAIS Index N1 - Date revised - 2011-12-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JDPSEH N1 - SubjectsTermNotLitGenreText - Social policy; Disabled; Social insurance; Performance; Workplaces; Computers; Cost; Adults; Disability insurance DO - http://dx.doi.org/10.1177/1044207310396509 ER - TY - JOUR T1 - Eating the strangers within: host control of intracellular bacteria via xenophagy AN - 904491022; 15632048 AB - Many bacterial pathogens rely on an intracellular cycle to ensure their proliferation within infected hosts, through their ability to avoid or circumvent host bactericidal pathways. Recent evidence supports an increasingly important role for the autophagy pathway in innate immune defences against intracellular pathogens, as a mechanism of capture of either cytosol-adapted or vacuolar bacteria that redirect them to the lysosomal compartment for killing. Antibacterial autophagy, also referred to as xenophagy, involves selective recognition of intracellular bacteria and their targeting to the autophagic machinery for degradation. Here we review recent advances in our molecular understanding of these processes, and in how bacteria have adapted to avoid xenophagy or even take advantage of this innate immune process. JF - Cellular Microbiology AU - Knodler, Leigh A AU - Celli, Jean AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1319 EP - 1327 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 13 IS - 9 SN - 1462-5814, 1462-5814 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Pathogens KW - Phagocytosis KW - Reviews KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904491022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Microbiology&rft.atitle=Eating+the+strangers+within%3A+host+control+of+intracellular+bacteria+via+xenophagy&rft.au=Knodler%2C+Leigh+A%3BCelli%2C+Jean&rft.aulast=Knodler&rft.aufirst=Leigh&rft.date=2011-09-01&rft.volume=13&rft.issue=9&rft.spage=1319&rft.isbn=&rft.btitle=&rft.title=Cellular+Microbiology&rft.issn=14625814&rft_id=info:doi/10.1111%2Fj.1462-5822.2011.01632.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Document feature - figure 2 N1 - Last updated - 2012-07-27 N1 - SubjectsTermNotLitGenreText - Reviews; Pathogens; Phagocytosis DO - http://dx.doi.org/10.1111/j.1462-5822.2011.01632.x ER - TY - JOUR T1 - A developmental shift in Black-White differences in depressive affect across adolescence and early adulthood: The influence of early adult social roles and socio-economic status AN - 902097770; 201119742 AB - This study examined Black-White differences in growth of depressive affect using a longitudinal sample of middle-class, suburban U.S. subjects (n = 956) that spanned from adolescence to early adulthood. Specifically, this study examined whether Black-White differences in growth of depressive affect shift over time, and the extent to which that shift, if any, was associated with racial differences in the rate and mental health consequences of early adult social roles (e.g., living arrangements, work/college status, and single parenthood) and socioeconomic status (SES). As expected, growth in depressive affect pivoted around the onset of early adulthood, with the trajectory pivoting upward for Black Americans and downward for White Americans. Due to deficits in SES, the relation between challenging early adult social roles-under/unemployment in particular-and growth in depressive affect was more positive for Black Americans. This differential 'vulnerability' appears to underlie racial differences in early adult growth (and by connection contribute to racial differences in growth pivot). The extent to which Black Americans were at a greater risk (relative to White Americans) for an upward pivot increased as the number of challenging roles increased. Black Americans facing only optimal early adult social roles were not at a greater risk, while those facing only challenging social roles were at the greatest risk. Adapted from the source document. JF - International Journal of Behavioral Development AU - Jager, Justin AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, USA jagerjo@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 457 EP - 469 PB - Sage Publications, Thousand Oaks, CA VL - 35 IS - 5 SN - 0165-0254, 0165-0254 KW - cumulative risk early adulthood mental health piece-wise growth curve modeling race KW - Racial differences KW - Black American people KW - Social roles KW - Depression KW - Socioeconomic status KW - Adulthood KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902097770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Behavioral+Development&rft.atitle=A+developmental+shift+in+Black-White+differences+in+depressive+affect+across+adolescence+and+early+adulthood%3A+The+influence+of+early+adult+social+roles+and+socio-economic+status&rft.au=Jager%2C+Justin&rft.aulast=Jager&rft.aufirst=Justin&rft.date=2011-09-01&rft.volume=35&rft.issue=5&rft.spage=457&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Behavioral+Development&rft.issn=01650254&rft_id=info:doi/10.1177%2F0165025411417504 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-11-02 N1 - Number of references - 87 N1 - Last updated - 2016-09-27 N1 - CODEN - IJBDDY N1 - SubjectsTermNotLitGenreText - Depression; Socioeconomic status; Black American people; Social roles; Adulthood; Racial differences DO - http://dx.doi.org/10.1177/0165025411417504 ER - TY - JOUR T1 - Relation of Study Design to Recruitment and Retention in CTN Trials AN - 902079943; 201123888 AB - Background: Recruitment and retention in randomized clinical trials are difficult in general and particularly so in trials of substance abuse treatments. Understanding trial design characteristics that could affect recruitment and retention rates would help in the design of future trials. Objective: To test whether any of the following factors are associated with recruitment or retention: type of intervention, type of therapy, duration of treatment, total duration of trial, number of treatment sessions, number of follow-up visits, number of primary assessments, timing of primary assessments, number of case report form (CRF) pages at baseline, and number of CRF pages for the entire trial. Methods: Recruitment and retention data from 24 Clinical Trials Network (CTN) trials conducted and completed between 2001 and 2010 were analyzed using single-factor analysis of variance and single-predictor regression methods to test their association with trial design characteristics. Results: Almost all of the analyses performed did not show statistically significant patterns between recruitment and retention rates and the trial design characteristics considered. Conclusion: In CTN trials, the relationship between assessment burden on participants and length of trial, on the one hand, and recruitment and retention, on the other, is not as strong and direct as expected. Other factors must impinge on the conduct of the trial to influence trial participation. Scientific Significance: Researchers may deem slightly more justifiable to permit inclusion of some of the design features that previously were assumed to have a strong, negative influence on recruitment and retention, and should consider other strategies that may have a stronger, more direct effect on trial participation. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Wakim, Paul G AU - Rosa, Carmen AU - Kothari, Prasad AU - Michel, Mary Ellen AD - Center for the Clinical Trials Network, National Institute on Drug Abuse, Maryland, USA pwakim@nida.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 426 EP - 433 PB - Taylor & Francis Inc., Philadelphia, PA VL - 37 IS - 5 SN - 0095-2990, 0095-2990 KW - primary outcome, treatment exposure, case report form (CRF), trial design characteristics KW - Substance Abuse KW - Participation KW - Attrition KW - Recruitment KW - Intervention KW - Medical Research KW - Treatment Methods KW - Trials KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902079943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Relation+of+Study+Design+to+Recruitment+and+Retention+in+CTN+Trials&rft.au=Wakim%2C+Paul+G%3BRosa%2C+Carmen%3BKothari%2C+Prasad%3BMichel%2C+Mary+Ellen&rft.aulast=Wakim&rft.aufirst=Paul&rft.date=2011-09-01&rft.volume=37&rft.issue=5&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/10.3109%2F00952990.2011.596972 LA - English DB - Sociological Abstracts N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-28 N1 - CODEN - AJDABD N1 - SubjectsTermNotLitGenreText - Trials; Attrition; Recruitment; Treatment Methods; Participation; Medical Research; Intervention; Substance Abuse DO - http://dx.doi.org/10.3109/00952990.2011.596972 ER - TY - JOUR T1 - An automated point-of-care system for immunodetection of staphylococcal enterotoxin B AN - 899151668; 15316177 AB - An automated point-of-care (POC) immunodetection system for immunological detection of staphylococcal enterotoxin B (SEB) was designed, fabricated, and tested. The system combines several elements: (i) enzyme-linked immunosorbent assay-lab-on-a-chip (ELISA-LOC) with fluidics, (ii) a charge-coupled device (CCD) camera detector, (iii) pumps and valves for fluid delivery to the ELISA-LOC, (iv) a computer interface board, and (v) a computer for controlling the fluidics, logging, and data analysis of the CCD data. The ELISA-LOC integrates a simple microfluidic system into a miniature 96-well sample plate, allowing the user to carry out immunological assays without a laboratory. The analyte is measured in a sandwich ELISA assay format combined with a sensitive electrochemiluminescence (ECL) detection method. Using the POC system, SEB, a major foodborne toxin, was detected at concentrations as low as 0.1 ng/ml. This is similar to the reported sensitivity of conventional ELISA. The open platform with simple modular fluid delivery automation design described here is interchangeable between detection systems, and because of its versatility it can also be used to automate many other LOC systems, simplifying LOC development. This new POC system is useful for carrying out various immunological and other complex medical assays without a laboratory and can easily be adapted for high-throughput biological screening in remote and resource-poor areas. JF - Analytical Biochemistry AU - Yang, Minghui AU - Sun, Steven AU - Kostov, Yordan AU - Rasooly, Avraham AD - Center for Advanced Sensor Technology, University of Maryland Baltimore County, Baltimore, MD 21250, USA, rasoolya@mail.nih.gov PY - 2011 SP - 74 EP - 81 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 416 IS - 1 SN - 0003-2697, 0003-2697 KW - Microbiology Abstracts B: Bacteriology KW - Point of care KW - ELISA KW - Lab-on-a-chip KW - Open platform KW - CCD KW - Microfabrication KW - Staphylococcal enterotoxins KW - Food safety KW - Logging KW - Enzyme-linked immunosorbent assay KW - Microfluidics KW - Data processing KW - Computers KW - Food KW - Cameras KW - Automation KW - Staphylococcal enterotoxin B KW - Immunosorbents KW - Toxins KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899151668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=An+automated+point-of-care+system+for+immunodetection+of+staphylococcal+enterotoxin+B&rft.au=Yang%2C+Minghui%3BSun%2C+Steven%3BKostov%2C+Yordan%3BRasooly%2C+Avraham&rft.aulast=Yang&rft.aufirst=Minghui&rft.date=2011-09-01&rft.volume=416&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/10.1016%2Fj.ab.2011.05.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2016-01-06 N1 - SubjectsTermNotLitGenreText - Logging; Microfluidics; Enzyme-linked immunosorbent assay; Data processing; Food; Computers; Cameras; Automation; Staphylococcal enterotoxin B; Toxins; Immunosorbents DO - http://dx.doi.org/10.1016/j.ab.2011.05.014 ER - TY - JOUR T1 - How to amend land subsidence treatment policies to solve coastal subsidence problems in Taiwan AN - 899148005; 15578396 AB - Coastal land subsidence is a serious problem in Taiwan. Starting in 1995, the goal of the "Land Subsidence Prevention and Treatment Implementation Program" is to restructure the aquaculture industry to reduce groundwater consumption and reduce coastal land subsidence problems. However, this goal has not been met. This study aims to determine the reasons for its failure through a literature review and an analysis of questionnaires of stakeholders taken over a 5-year period, and design a new program to resolve these problems. The study was conducted in 2005-2009. According to the literature, over-pumping of groundwater around densely concentrated coastal fish ponds is the primary cause of coastal land subsidence. However, the key measure of the program was to establish aquaculture districts primarily in subsiding coastal areas, which failed to reduce land subsidence. In addition, the program did not consider reductions in agricultural and industrial groundwater use. Results of the questionnaire survey were in accord with the literature review results. This paper proposes to establish a "Fish Farming Abandonment Program" offering compensation payments and job training to fish farmers who leave the aquaculture business, thus reducing the amount of coastal land devoted to fish farming, decreasing groundwater consumption, and halting further coastal subsidence. In addition, the proposal also suggests adjustments to the structure of the agriculture industry. The results of this study can serve as a reference for governments of Taiwan and other countries. JF - Regional Environmental Change AU - Sun, Peter Lin AU - Yang, Chun-Chou AU - Lin, Tai-Wai AD - Institute of Aquaculture, National Pingtung University of Science and Technology, Nei-Pu, Pingtung, 91207, Taiwan, ROC Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 679 EP - 691 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 11 IS - 3 SN - 1436-3798, 1436-3798 KW - ASFA 1: Biological Sciences & Living Resources; ASFA Aquaculture Abstracts; Sustainability Science Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Meteorological & Geoastrophysical Abstracts KW - Agriculture KW - Marine KW - Training KW - Climate change KW - Pond culture KW - Aquaculture KW - Ponds KW - Coastal zone KW - Aquaculture enterprises KW - ISEW, Taiwan KW - Coastal subsidence KW - Literature reviews KW - Reviews KW - Subsidence KW - environmental changes KW - prevention KW - Fish KW - Marine aquaculture KW - Groundwater KW - Land subsidence KW - Fish culture KW - Fish ponds KW - Q5 08503:Characteristics, behavior and fate KW - M3 1010:Issues in Sustainable Development KW - Q3 08582:Fish culture KW - Q1 08121:Law, policy, economics and social sciences KW - M2 556.3:Groundwater Hydrology (556.3) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899148005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regional+Environmental+Change&rft.atitle=How+to+amend+land+subsidence+treatment+policies+to+solve+coastal+subsidence+problems+in+Taiwan&rft.au=Sun%2C+Peter+Lin%3BYang%2C+Chun-Chou%3BLin%2C+Tai-Wai&rft.aulast=Sun&rft.aufirst=Peter&rft.date=2011-09-01&rft.volume=11&rft.issue=3&rft.spage=679&rft.isbn=&rft.btitle=&rft.title=Regional+Environmental+Change&rft.issn=14363798&rft_id=info:doi/10.1007%2Fs10113-010-0199-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Aquaculture enterprises; Coastal zone; Literature reviews; Climate change; Subsidence; Pond culture; Marine aquaculture; Fish culture; Fish ponds; Agriculture; Coastal subsidence; Land subsidence; Training; Reviews; prevention; environmental changes; Fish; Groundwater; Aquaculture; Ponds; ISEW, Taiwan; Marine DO - http://dx.doi.org/10.1007/s10113-010-0199-0 ER - TY - JOUR T1 - RISKY SINGLE-OCCASION DRINKING AN - 899138358; 15730935 JF - Addiction AU - Dawson, Deborah A AD - Kelly Government Services Contractor to the National Institute on Alcohol Abuse and Alcoholism National Institutes of Health, Bethesda, MD, USA, E-mail: ddawsonillco.niaaa.nih.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1709 EP - 1710 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 106 IS - 9 SN - 0965-2140, 0965-2140 KW - Risk Abstracts KW - Alcohol KW - Risk taking KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899138358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=RISKY+SINGLE-OCCASION+DRINKING&rft.au=Dawson%2C+Deborah+A&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2011-09-01&rft.volume=106&rft.issue=9&rft.spage=1709&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2011.03530.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Document feature - figure 0 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Alcohol; Risk taking DO - http://dx.doi.org/10.1111/j.1360-0443.2011.03530.x ER - TY - JOUR T1 - Designing prospective cohort studies for assessing reproductive and developmental toxicity during sensitive windows of human reproduction and development--the LIFE Study. AN - 893723328; 21819423 AB - The relationship between the environment and human fecundity and fertility remains virtually unstudied from a couple-based perspective in which longitudinal exposure data and biospecimens are captured across sensitive windows. In response, we completed the LIFE Study with methodology that intended to empirically evaluate a priori purported methodological challenges: implementation of population-based sampling frameworks suitable for recruiting couples planning pregnancy; obtaining environmental data across sensitive windows of reproduction and development; home-based biospecimen collection; and development of a data management system for hierarchical exposome data. We used two sampling frameworks (i.e., fish/wildlife licence registry and a direct marketing database) for 16 targeted counties with presumed environmental exposures to persistent organochlorine chemicals to recruit 501 couples planning pregnancies for prospective longitudinal follow-up while trying to conceive and throughout pregnancy. Enrolment rates varied from <1% of the targeted population (n = 424,423) to 42% of eligible couples who were successfully screened; 84% of the targeted population could not be reached, while 36% refused screening. Among enrolled couples, ∼ 85% completed daily journals while trying; 82% of pregnant women completed daily early pregnancy journals, and 80% completed monthly pregnancy journals. All couples provided baseline blood/urine samples; 94% of men provided one or more semen samples and 98% of women provided one or more saliva samples. Women successfully used urinary fertility monitors for identifying ovulation and home pregnancy test kits. Couples can be recruited for preconception cohorts and will comply with intensive data collection across sensitive windows. However, appropriately sized sampling frameworks are critical, given the small percentage of couples contacted found eligible and reportedly planning pregnancy at any point in time. © Published 2011. This article is a US Government work and is in the public domain in the USA. JF - Paediatric and perinatal epidemiology AU - Buck Louis, Germaine M AU - Schisterman, Enrique F AU - Sweeney, Anne M AU - Wilcosky, Timothy C AU - Gore-Langton, Robert E AU - Lynch, Courtney D AU - Boyd Barr, Dana AU - Schrader, Steven M AU - Kim, Sungduk AU - Chen, Zhen AU - Sundaram, Rajeshwari AD - Division of Epidemiology, Statistics & Prevention Research, Eunice Kennedy Shriver National Institute of Child Health & Human Development, NIH, Rockville, MD20852, USA. louisg@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 413 EP - 424 VL - 25 IS - 5 KW - Environmental Pollutants KW - 0 KW - Hydrocarbons, Chlorinated KW - Index Medicus KW - Young Adult KW - Hydrocarbons, Chlorinated -- blood KW - Epidemiologic Methods KW - Humans KW - Semen -- chemistry KW - Hydrocarbons, Chlorinated -- urine KW - Fetal Development -- drug effects KW - Pregnancy KW - Prospective Studies KW - Adult KW - Cohort Studies KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Maternal Exposure -- adverse effects KW - Reproduction -- drug effects KW - Environmental Pollutants -- urine KW - Environmental Exposure -- adverse effects KW - Research Design KW - Environmental Pollutants -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893723328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Paediatric+and+perinatal+epidemiology&rft.atitle=Designing+prospective+cohort+studies+for+assessing+reproductive+and+developmental+toxicity+during+sensitive+windows+of+human+reproduction+and+development--the+LIFE+Study.&rft.au=Buck+Louis%2C+Germaine+M%3BSchisterman%2C+Enrique+F%3BSweeney%2C+Anne+M%3BWilcosky%2C+Timothy+C%3BGore-Langton%2C+Robert+E%3BLynch%2C+Courtney+D%3BBoyd+Barr%2C+Dana%3BSchrader%2C+Steven+M%3BKim%2C+Sungduk%3BChen%2C+Zhen%3BSundaram%2C+Rajeshwari&rft.aulast=Buck+Louis&rft.aufirst=Germaine&rft.date=2011-09-01&rft.volume=25&rft.issue=5&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Paediatric+and+perinatal+epidemiology&rft.issn=1365-3016&rft_id=info:doi/10.1111%2Fj.1365-3016.2011.01205.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-20 N1 - Date created - 2011-08-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Health Soc Behav. 1983 Dec;24(4):385-96 [6668417] Fertil Steril. 2004 Feb;81(2):384-92 [14967378] Hum Reprod. 1996 Feb;11(2):406-12 [8671233] Paediatr Perinat Epidemiol. 1997 Jul;11(3):345-58 [9246695] Reprod Toxicol. 1998 Jan-Feb;12(1):19-27 [9431569] Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50 [16103423] Epidemiology. 2006 Jul;17(4):440-9 [16755258] Hum Reprod. 2007 Jun;22(6):1634-7 [17344224] Fertil Steril. 2008 Feb;89(2 Suppl):e119-21 [18308052] Am J Epidemiol. 2009 Jan 1;169(1):105-12 [18974081] Hum Reprod. 2009 Feb;24(2):451-8 [18940895] Acta Obstet Gynecol Scand. 2000 Jan;79(1):43-8 [10646815] Hum Reprod. 2000 Dec;15(12):2478-82 [11098014] Hum Reprod. 2001 May;16(5):972-8 [11331648] Fertil Steril. 2003 May;79(5):1136-40 [12738508] Environ Health Perspect. 2004 Jan;112(1):79-86 [14698935] Am J Obstet Gynecol. 2004 Jan;190(1):100-5 [14749643] J Occup Med. 1989 Dec;31(12):980-5 [2614538] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-3016.2011.01205.x ER - TY - JOUR T1 - Insecticide Residues in Eggplant Fruits, Soil, and Water in the Largest Eggplant-Producing Area in the Philippines AN - 888100410; 15454168 AB - This study looked into the insecticide residues in eggplant, soil, and water samples in the largest eggplant-producing community in the Philippines as well as to analyze the fate of insecticides. The study area consisted of eggplant farms in a community in the largest eggplant producer in the Philippines. A total of 20 of the environmental samples were taken from the farms and analyzed using gas chromatography. The samples were distributed spatially over a mean distance of 451 m (s.d.=20.2 m). For eggplant pesticide application, the mean spraying time of the farmers was 1.4 (sdv=0.53)h/day, 4.13 (sdv=1.9)days/week, 3.79 (sdv=0.22)weeks/month, and 1 year/cropping season. Forty percent of the farm samples of eggplants had positive reading of insecticides cypermethrin and chlorpyrifos between 0.02 and 0.03 mg/kg. There was no positive reading for the 20 water samples. There was only one positive reading of chlorpyrifos in one farm out of 20 soil samples at 0.03 mg/kg. Although Prevathon and Malathion were used by all the farms for eggplant pesticide application, the liter-years of exposure to pesticide was very low for both (0.06, 0.56). Although Brodan and Magnum were not prevalently used, they had the highest liter-years of exposure to pesticide at 4.73 for chlorpyrifos, and 6.09 for cypermethrin. The amount and duration of use of insecticide is important in the determination of its persistence in vegetables and in the environment. In this study, Brodan was the largest and longest used insecticide for eggplants which explains why there was reading for both cypermethrin and chlorpyrifos in the eggplants, but none for Malathion and chlorantraniliprole. The presence of insecticide in water, soil, and plants is also based on its environmental fate. Pesticide regulation and pesticide residue monitoring have been pursued to varying degrees of success in the Philippines, but implementation is considered inadequate. The study also suggests for better implementation of pesticide regulation. JF - Water, Air, & Soil Pollution AU - Lu, Jinky Leilanie AD - National Institutes of Health, University of the Philippines Manila, NIH Bldg, P. Gil Street, Ermita, Manila, Philippines, 1100, jinkyULlu@yahoo.com Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 413 EP - 422 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 220 IS - 1-4 SN - 0049-6979, 0049-6979 KW - Meteorological & Geoastrophysical Abstracts; Environment Abstracts; Pollution Abstracts KW - Atmospheric pollution KW - Soil pollution KW - Philippines KW - farms KW - M2:551.5 KW - P 2000:FRESHWATER POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888100410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water%2C+Air%2C+%26+Soil+Pollution&rft.atitle=Insecticide+Residues+in+Eggplant+Fruits%2C+Soil%2C+and+Water+in+the+Largest+Eggplant-Producing+Area+in+the+Philippines&rft.au=Lu%2C+Jinky+Leilanie&rft.aulast=Lu&rft.aufirst=Jinky&rft.date=2011-09-01&rft.volume=220&rft.issue=1-4&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Water%2C+Air%2C+%26+Soil+Pollution&rft.issn=00496979&rft_id=info:doi/10.1007%2Fs11270-011-0778-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Soil pollution; farms; Philippines DO - http://dx.doi.org/10.1007/s11270-011-0778-9 ER - TY - JOUR T1 - Randomized, Placebo-controlled Clinical Trial of an Aerosolized [Beta]^sub 2^-Agonist for Treatment of Acute Lung Injury AN - 887636215 JF - American Journal of Respiratory and Critical Care Medicine AU - Anonymous Y1 - 2011/09/01/ PY - 2011 DA - 2011 Sep 01 SP - 561 EP - 568 CY - New York PB - American Thoracic Society VL - 184 IS - 5 SN - 1073449X KW - Medical Sciences--Respiratory Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/887636215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Randomized%2C+Placebo-controlled+Clinical+Trial+of+an+Aerosolized+%5BBeta%5D%5Esub+2%5E-Agonist+for+Treatment+of+Acute+Lung+Injury&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-09-01&rft.volume=184&rft.issue=5&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Sep 1, 2011 N1 - Last updated - 2017-01-07 ER - TY - JOUR T1 - Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells. AN - 887505099; 21865652 AB - It has long been hypothesized that abnormalities in lipid biology contribute to degenerative brain diseases. Consistent with this, emerging epidemiologic evidence links lipid alterations with Parkinson disease (PD), and disruption of lipid metabolism has been found to predispose to α-synuclein toxicity. We therefore investigated whether Parkin, an E3 ubiquitin ligase found to be defective in patients with early onset PD, regulates systemic lipid metabolism. We perturbed lipid levels by exposing Parkin+/+ and Parkin-/- mice to a high-fat and -cholesterol diet (HFD). Parkin-/- mice resisted weight gain, steatohepatitis, and insulin resistance. In wild-type mice, the HFD markedly increased hepatic Parkin levels in parallel with lipid transport proteins, including CD36, Sr-B1, and FABP. These lipid transport proteins were not induced in Parkin-/- mice. The role of Parkin in fat uptake was confirmed by increased oleate accumulation in hepatocytes overexpressing Parkin and decreased uptake in Parkin-/- mouse embryonic fibroblasts and patient cells harboring complex heterozygous mutations in the Parkin-encoding gene PARK2. Parkin conferred this effect, in part, via ubiquitin-mediated stabilization of the lipid transporter CD36. Reconstitution of Parkin restored hepatic fat uptake and CD36 levels in Parkin-/- mice, and Parkin augmented fat accumulation during adipocyte differentiation. These results demonstrate that Parkin is regulated in a lipid-dependent manner and modulates systemic fat uptake via ubiquitin ligase-dependent effects. Whether this metabolic regulation contributes to premature Parkinsonism warrants investigation. JF - The Journal of clinical investigation AU - Kim, Kye-Young AU - Stevens, Mark V AU - Akter, M Hasina AU - Rusk, Sarah E AU - Huang, Robert J AU - Cohen, Alexandra AU - Noguchi, Audrey AU - Springer, Danielle AU - Bocharov, Alexander V AU - Eggerman, Tomas L AU - Suen, Der-Fen AU - Youle, Richard J AU - Amar, Marcelo AU - Remaley, Alan T AU - Sack, Michael N AD - Center for Molecular Medicine, NHLBI, 10 Center Drive, Bethesda, Maryland, 20892-1454, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 3701 EP - 3712 VL - 121 IS - 9 KW - Antigens, CD36 KW - 0 KW - Dietary Fats KW - Insulin KW - alpha-Synuclein KW - Ubiquitin-Protein Ligases KW - EC 2.3.2.27 KW - parkin protein KW - Glucose KW - IY9XDZ35W2 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Antigens, CD36 -- metabolism KW - alpha-Synuclein -- metabolism KW - Adipose Tissue -- cytology KW - Antigens, CD36 -- genetics KW - Glucose -- metabolism KW - Humans KW - Insulin -- blood KW - Parkinson Disease -- metabolism KW - Mice KW - Weight Gain KW - Energy Metabolism KW - Parkinson Disease -- genetics KW - Mice, Knockout KW - Eating KW - Adipose Tissue -- metabolism KW - Body Temperature KW - Mice, Inbred C57BL KW - Insulin Resistance KW - Male KW - Cell Line KW - Dietary Fats -- metabolism KW - Ubiquitin-Protein Ligases -- genetics KW - Ubiquitin-Protein Ligases -- metabolism KW - Lipid Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/887505099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Parkin+is+a+lipid-responsive+regulator+of+fat+uptake+in+mice+and+mutant+human+cells.&rft.au=Kim%2C+Kye-Young%3BStevens%2C+Mark+V%3BAkter%2C+M+Hasina%3BRusk%2C+Sarah+E%3BHuang%2C+Robert+J%3BCohen%2C+Alexandra%3BNoguchi%2C+Audrey%3BSpringer%2C+Danielle%3BBocharov%2C+Alexander+V%3BEggerman%2C+Tomas+L%3BSuen%2C+Der-Fen%3BYoule%2C+Richard+J%3BAmar%2C+Marcelo%3BRemaley%2C+Alan+T%3BSack%2C+Michael+N&rft.aulast=Kim&rft.aufirst=Kye-Young&rft.date=2011-09-01&rft.volume=121&rft.issue=9&rft.spage=3701&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=1558-8238&rft_id=info:doi/10.1172%2FJCI44736 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-31 N1 - Date created - 2011-09-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurochem. 2008 Jun;105(5):1806-19 [18248624] J Biol Chem. 2008 May 16;283(20):13578-85 [18353783] Mov Disord. 2008 May 15;23(7):1013-8 [18381649] Nat Genet. 2000 Jul;25(3):302-5 [10888878] J Clin Invest. 2002 May;109(10):1381-9 [12021254] Proc Natl Acad Sci U S A. 2003 May 13;100(10):5956-61 [12719539] Hum Mol Genet. 2003 Jun 15;12(12):1427-37 [12783850] Hum Mol Genet. 2003 Oct 15;12(20):2587-97 [12925569] J Biol Chem. 2003 Oct 31;278(44):43628-35 [12930822] Science. 2003 Dec 5;302(5651):1769-72 [14657499] Development. 2004 May;131(9):2183-94 [15073152] J Biol Chem. 2004 Apr 30;279(18):18614-22 [14985362] Mov Disord. 2004 Oct;19(10):1146-57 [15390068] Biochem J. 1988 Feb 15;250(1):203-7 [3355511] Neuroscience. 1998 Apr;83(3):791-8 [9483562] Nature. 1998 Apr 9;392(6676):605-8 [9560156] J Clin Invest. 2004 Nov;114(9):1326-33 [15520865] Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2174-9 [15684050] J Neurosci. 2005 Feb 23;25(8):2002-9 [15728840] J Clin Invest. 2005 Apr;115(4):1030-8 [15761499] Neurology. 2005 Jun 28;64(12):2040-5 [15985568] Anal Biochem. 2005 Aug 15;343(2):277-82 [15993372] J Neurosci. 2005 Aug 31;25(35):7968-78 [16135753] J Biol Chem. 2006 Feb 10;281(6):3204-9 [16339143] Hum Genet. 2008 Aug;124(1):63-71 [18560894] FASEB J. 2008 Sep;22(9):3135-45 [18495756] J Biol Chem. 2008 Oct 31;283(44):29650-7 [18728004] J Immunol. 2008 Nov 15;181(10):7147-56 [18981136] J Cell Biol. 2008 Dec 1;183(5):795-803 [19029340] J Clin Invest. 2009 Mar;119(3):650-60 [19229105] J Biol Chem. 2009 Mar 27;284(13):8209 [19008216] J Med Genet. 2009 Jun;46(6):375-81 [19351622] Autophagy. 2009 Jul;5(5):706-8 [19377297] Science. 2009 Jul 3;325(5936):100-4 [19520913] J Biol Chem. 2009 Aug 21;284(34):22938-51 [19546216] J Neurochem. 2009 Nov;111(3):696-702 [19694908] Nat Cell Biol. 2009 Nov;11(11):1370-5 [19801972] Mol Cell. 2009 Dec 25;36(6):1034-47 [20064468] Nat Cell Biol. 2010 Feb;12(2):119-31 [20098416] J Biol Chem. 2010 Apr 30;285(18):13580-8 [20189990] J Cell Biol. 2010 Dec 27;191(7):1367-80 [21173115] Hum Mol Genet. 2006 Jul 1;15(13):2059-75 [16714300] Nat Cell Biol. 2006 Aug;8(8):834-42 [16862145] J Physiol. 2006 Sep 1;575(Pt 2):373-7 [16840513] Am J Epidemiol. 2006 Nov 15;164(10):998-1002 [16905642] Diabetes. 2006 Dec;55(12):3411-7 [17130487] Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3095-100 [17360614] Comment In: J Clin Invest. 2011 Sep;121(9):3389-92 [21865651] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1172/JCI44736 ER - TY - JOUR T1 - The dgt gene of Escherichia coli facilitates thymine utilization in thymine-requiring strains. AN - 887502926; 21736641 AB - The Escherichia coli dGTP triphosphohydrolase (dGTPase) encoded by the dgt gene catalyses the hydrolysis of dGTP to deoxyguanosine and triphosphate. The recent discovery of a mutator effect associated with deletion of dgt indicated participation of the triphosphohydrolase in preventing mutagenesis. Here, we have investigated the possible involvement of dgt in facilitating thymine utilization through its ability to provide intracellular deoxyguanosine, which is readily converted by the DeoD phosphorylase to deoxyribose-1-phosphate, the critical intermediate that enables uptake and utilization of thymine. Indeed, we observed that the minimal amount of thymine required for growth of thymine-requiring (thyA) strains decreased with increased expression level of the dgt gene. As expected, this dgt-mediated effect was dependent on the DeoD purine nucleoside phosphorylase. We also observed that thyA strains experience growth difficulties upon nutritional shift-up and that the dgt gene facilitates adaptation to the new growth conditions. Blockage of the alternative yjjG (dUMP phosphatase) pathway for deoxyribose-1-phosphate generation greatly exacerbated the severity of thymine starvation in enriched media, and under these conditions the dgt pathway becomes crucial in protecting the cells against thymineless death. Overall, our results suggest that the dgt-dependent pathway for deoxyribose-1-phosphate generation may operate under various cell conditions to provide deoxyribosyl donors. © Published 2011. This article is a US Government work and is in the public domain in the USA. JF - Molecular microbiology AU - Itsko, Mark AU - Schaaper, Roel M AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 1221 EP - 1232 VL - 81 IS - 5 KW - Deoxyguanine Nucleotides KW - 0 KW - Escherichia coli Proteins KW - Deoxyribose KW - 533-67-5 KW - deoxyguanosine triphosphate KW - 8C2O37Y44Q KW - Purine-Nucleoside Phosphorylase KW - EC 2.4.2.1 KW - YjjG protein, E coli KW - EC 3.1.3.- KW - N-Glycosyl Hydrolases KW - EC 3.2.2.- KW - GTP Phosphohydrolases KW - EC 3.6.1.- KW - Deoxyguanosine KW - G9481N71RO KW - Thymine KW - QR26YLT7LT KW - Index Medicus KW - Purine-Nucleoside Phosphorylase -- metabolism KW - Deoxyguanosine -- metabolism KW - Deoxyguanine Nucleotides -- metabolism KW - Deoxyribose -- genetics KW - Deoxyribose -- metabolism KW - Sequence Deletion KW - Escherichia coli Proteins -- metabolism KW - Escherichia coli -- metabolism KW - Thymine -- metabolism KW - GTP Phosphohydrolases -- genetics KW - N-Glycosyl Hydrolases -- metabolism KW - GTP Phosphohydrolases -- metabolism KW - Escherichia coli -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/887502926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=The+dgt+gene+of+Escherichia+coli+facilitates+thymine+utilization+in+thymine-requiring+strains.&rft.au=Itsko%2C+Mark%3BSchaaper%2C+Roel+M&rft.aulast=Itsko&rft.aufirst=Mark&rft.date=2011-09-01&rft.volume=81&rft.issue=5&rft.spage=1221&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=1365-2958&rft_id=info:doi/10.1111%2Fj.1365-2958.2011.07756.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-02-21 N1 - Date created - 2011-09-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Microbiol. 2004 Mar;51(5):1279-95 [14982624] J Biochem. 2004 Aug;136(2):221-31 [15496593] Cold Spring Harb Symp Quant Biol. 1968;33:809-22 [4892010] Nature. 1970 Apr 11;226(5241):126-31 [4908371] Eur J Biochem. 1970 Jul;15(1):191-202 [4923156] J Bacteriol. 1971 Feb;105(2):657-65 [5541539] Mol Gen Genet. 1971;111(1):77-83 [4932244] J Mol Biol. 1971 Aug 28;60(1):75-86 [4937195] J Biol Chem. 1972 Nov 25;247(22):7116-22 [4565077] J Bacteriol. 1973 May;114(2):824-37 [4574701] Eur J Biochem. 1973 Dec 17;40(2):345-54 [4592648] Mol Gen Genet. 1978 Feb 16;159(2):191-202 [204861] Proc Natl Acad Sci U S A. 1983 Mar;80(6):1669-73 [6300866] J Biol Chem. 1987 Apr 15;262(11):5288-92 [3549718] J Biol Chem. 1988 Jan 25;263(3):1494-9 [2826481] Proc Natl Acad Sci U S A. 1988 Apr;85(8):2563-7 [2833745] Microbiol Rev. 1989 Mar;53(1):1-24 [2540407] Proc Natl Acad Sci U S A. 1990 Apr;87(7):2740-4 [2157212] Gene. 1990 Apr 30;89(1):13-8 [2165018] J Biol Chem. 1993 Sep 25;268(27):20046-54 [8397198] J Bacteriol. 1994 Apr;176(8):2194-9 [8157589] Mutat Res. 1994 Aug;318(1):1-64 [7519315] Mol Microbiol. 1995 Mar;15(5):789-94 [7596281] Pharmacol Ther. 1995;67(2):155-86 [7494863] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5 [10829079] J Mol Biol. 2000 Aug 25;301(4):827-37 [10966789] Prog Nucleic Acid Res Mol Biol. 1998;59:205-55 [9427844] Annu Rev Microbiol. 1998;52:591-625 [9891809] Biochim Biophys Acta. 1958 Nov;30(2):428-9 [13607463] J Gen Microbiol. 1958 Dec;19(3):607-16 [13611203] Biochim Biophys Acta. 1962 Nov 26;61:775-90 [14034805] J Biol Chem. 1956 Jan;218(1):97-106 [13278318] J Biol Chem. 2004 Dec 24;279(52):54687-94 [15489502] Mol Microbiol. 2006 Jan;59(1):5-19 [16359314] J Bacteriol. 2006 Mar;188(5):1667-79 [16484178] J Bacteriol. 2007 Mar;189(5):2186-9 [17189366] FEMS Microbiol Lett. 2007 May;270(1):49-57 [17286574] J Bacteriol. 2007 Nov;189(21):7922-6 [17827303] J Bacteriol. 2008 Nov;190(21):6931-9 [18776019] FEBS J. 2009 Jun;276(12):3211-21 [19438719] PLoS Genet. 2010 Mar;6(3):e1000865 [20221259] Mol Microbiol. 2010 Mar;75(6):1455-67 [20132444] Genes Cells. 2010 Jun;15(6):619-34 [20465561] ACS Chem Biol. 2010 Aug 20;5(8):787-95 [20553049] DNA Repair (Amst). 2011 Jan 2;10(1):94-101 [21074501] J Biol Chem. 2001 Feb 23;276(8):5518-24 [11078735] Nucleic Acids Res. 2003 Jan 15;31(2):517-31 [12527759] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2958.2011.07756.x ER - TY - JOUR T1 - Estimating water supply arsenic levels in the New England Bladder Cancer Study. AN - 887501970; 21421449 AB - Ingestion of inorganic arsenic in drinking water is recognized as a cause of bladder cancer when levels are relatively high (≥ 150 µg/L). The epidemiologic evidence is less clear at the low-to-moderate concentrations typically observed in the United States. Accurate retrospective exposure assessment over a long time period is a major challenge in conducting epidemiologic studies of environmental factors and diseases with long latency, such as cancer. We estimated arsenic concentrations in the water supplies of 2,611 participants in a population-based case-control study in northern New England. Estimates covered the lifetimes of most study participants and were based on a combination of arsenic measurements at the homes of the participants and statistical modeling of arsenic concentrations in the water supply of both past and current homes. We assigned a residential water supply arsenic concentration for 165,138 (95%) of the total 173,361 lifetime exposure years (EYs) and a workplace water supply arsenic level for 85,195 EYs (86% of reported occupational years). Three methods accounted for 93% of the residential estimates of arsenic concentration: direct measurement of water samples (27%; median, 0.3 µg/L; range, 0.1-11.5), statistical models of water utility measurement data (49%; median, 0.4 µg/L; range, 0.3-3.3), and statistical models of arsenic concentrations in wells using aquifers in New England (17%; median, 1.6 µg/L; range, 0.6-22.4). We used a different validation procedure for each of the three methods, and found our estimated levels to be comparable with available measured concentrations. This methodology allowed us to calculate potential drinking water exposure over long periods. JF - Environmental health perspectives AU - Nuckols, John R AU - Freeman, Laura E Beane AU - Lubin, Jay H AU - Airola, Matthew S AU - Baris, Dalsu AU - Ayotte, Joseph D AU - Taylor, Anne AU - Paulu, Chris AU - Karagas, Margaret R AU - Colt, Joanne AU - Ward, Mary H AU - Huang, An-Tsun AU - Bress, William AU - Cherala, Sai AU - Silverman, Debra T AU - Cantor, Kenneth P AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. jnuckols@colostate.edu Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 1279 EP - 1285 VL - 119 IS - 9 KW - Drinking Water KW - 0 KW - Water Pollutants, Chemical KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Maine -- epidemiology KW - Young Adult KW - Regression Analysis KW - New Hampshire -- epidemiology KW - Humans KW - Vermont -- epidemiology KW - Retrospective Studies KW - Infant, Newborn KW - Aged KW - Child KW - Risk Assessment KW - Infant KW - Adult KW - Case-Control Studies KW - Environmental Exposure KW - Middle Aged KW - Epidemiological Monitoring KW - Adolescent KW - Male KW - Female KW - Arsenic -- analysis KW - Water Pollutants, Chemical -- analysis KW - Urinary Bladder Neoplasms -- epidemiology KW - Drinking Water -- chemistry KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/887501970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Estimating+water+supply+arsenic+levels+in+the+New+England+Bladder+Cancer+Study.&rft.au=Nuckols%2C+John+R%3BFreeman%2C+Laura+E+Beane%3BLubin%2C+Jay+H%3BAirola%2C+Matthew+S%3BBaris%2C+Dalsu%3BAyotte%2C+Joseph+D%3BTaylor%2C+Anne%3BPaulu%2C+Chris%3BKaragas%2C+Margaret+R%3BColt%2C+Joanne%3BWard%2C+Mary+H%3BHuang%2C+An-Tsun%3BBress%2C+William%3BCherala%2C+Sai%3BSilverman%2C+Debra+T%3BCantor%2C+Kenneth+P&rft.aulast=Nuckols&rft.aufirst=John&rft.date=2011-09-01&rft.volume=119&rft.issue=9&rft.spage=1279&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1002345 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-13 N1 - Date created - 2011-09-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Sci Technol. 2003 May 15;37(10):2075-83 [12785510] Int J Occup Med Environ Health. 2001;14(2):171-5 [11548067] Am J Epidemiol. 2004 Feb 15;159(4):381-9 [14769642] Environ Health Perspect. 2004 Jun;112(9):1007-15 [15198921] Cancer Causes Control. 2004 Jun;15(5):465-72 [15286466] Am J Epidemiol. 1995 Mar 15;141(6):523-30 [7900719] Environ Health Perspect. 1998 Aug;106 Suppl 4:1047-50 [9703491] Environ Health Perspect. 1999 Sep;107(9):705-10 [10464069] Environ Health Perspect. 2004 Dec;112(17):1691-6 [15579415] IARC Monogr Eval Carcinog Risks Hum. 2004;84:269-477 [15645578] Environ Sci Technol. 2006 Jun 1;40(11):3578-85 [16786697] Int Arch Occup Environ Health. 2007 Jan;80(3):184-97 [16897097] J Natl Cancer Inst. 2007 Jun 20;99(12):920-8 [17565158] Toxicol Appl Pharmacol. 2007 Aug 1;222(3):252-7 [17382983] Environ Health Perspect. 2008 Feb;116(2):231-7 [18288323] Occup Environ Med. 2008 Jun;65(6):420-9 [18032532] Regul Toxicol Pharmacol. 2008 Dec;52(3):299-310 [18783726] Lancet Oncol. 2009 May;10(5):453-4 [19418618] J Natl Cancer Inst. 2009 Nov 18;101(22):1553-61 [19917915] J Expo Sci Environ Epidemiol. 2010 May;20(3):245-54 [19401722] Am J Epidemiol. 2003 Dec 15;158(12):1193-201 [14652304] Erratum In: Environ Health Perspect. 2011 Dec;119(12):A509 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.1002345 ER - TY - JOUR T1 - Cytotoxic activity of immunotoxin SS1P is modulated by TACE-dependent mesothelin shedding. AN - 887501489; 21775520 AB - Mesothelin is a cell-surface tumor-associated antigen expressed in several human cancers. The limited expression of mesothelin on normal tissues and its high expression in many cancers make it an attractive candidate for targeted therapies using monoclonal antibodies, immunoconjugates, and immunotoxins. Mesothelin is actively shed from the cell surface and is present in the serum of patients with malignant mesothelioma, which could negatively affect the response to these therapies. We have found that mesothelin sheddase activity is mediated by a TNF-α converting enzyme (TACE), a member of the matrix metalloproteinase/a disintegrin and metalloprotease family. We showed that EGF and TIMP-3 act through TACE as endogenous regulators of mesothelin shedding. We also found that reducing shedding significantly improved the in vitro cytotoxicity of immunotoxin SS1P, which targets mesothelin and is currently in clinical trials for the treatment of patients with mesothelioma and lung cancer. Our findings provide a mechanistic understanding of mesothelin shedding and could help improve mesothelin-based targeted therapies. ©2011 AACR. JF - Cancer research AU - Zhang, Yujian AU - Chertov, Oleg AU - Zhang, Jingli AU - Hassan, Raffit AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA. Y1 - 2011/09/01/ PY - 2011 DA - 2011 Sep 01 SP - 5915 EP - 5922 VL - 71 IS - 17 KW - Antibodies, Monoclonal KW - 0 KW - Cytotoxins KW - GPI-Linked Proteins KW - SS1(dsFv)PE38 KW - Tissue Inhibitor of Metalloproteinase-3 KW - mesothelin KW - Epidermal Growth Factor KW - 62229-50-9 KW - ADAM Proteins KW - EC 3.4.24.- KW - ADAM17 Protein KW - EC 3.4.24.86 KW - ADAM17 protein, human KW - Index Medicus KW - Tissue Inhibitor of Metalloproteinase-3 -- metabolism KW - Mesothelioma -- metabolism KW - Humans KW - Cell Line, Tumor KW - Epidermal Growth Factor -- metabolism KW - ADAM Proteins -- metabolism KW - GPI-Linked Proteins -- metabolism KW - Cytotoxins -- pharmacology KW - Antibodies, Monoclonal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/887501489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Cytotoxic+activity+of+immunotoxin+SS1P+is+modulated+by+TACE-dependent+mesothelin+shedding.&rft.au=Zhang%2C+Yujian%3BChertov%2C+Oleg%3BZhang%2C+Jingli%3BHassan%2C+Raffit%3BPastan%2C+Ira&rft.aulast=Zhang&rft.aufirst=Yujian&rft.date=2011-09-01&rft.volume=71&rft.issue=17&rft.spage=5915&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-11-0466 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-25 N1 - Date created - 2011-09-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2007 Mar 16;282(11):8325-31 [17227756] Exp Cell Res. 2006 Dec 10;312(20):3969-80 [17010968] Curr Pharm Des. 2007;13(20):2087-100 [17627541] Clin Cancer Res. 2007 Sep 1;13(17):5144-9 [17785569] Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17099-104 [17940013] Clin Cancer Res. 2007 Dec 1;13(23):7166-71 [18056197] Cancer Sci. 2008 Mar;99(3):590-4 [18167128] FASEB J. 2008 Oct;22(10):3515-24 [18632849] Biol Chem. 2008 Aug;389(8):1075-84 [18979631] Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3360-5 [19211796] Curr Pharm Des. 2009;15(20):2319-35 [19601834] Clin Cancer Res. 2009 Aug 15;15(16):5274-9 [19671873] Cancer Res. 2010 Jan 1;70(1):109-18 [20028856] Cancer Res. 2010 Feb 1;70(3):1082-9 [20103626] Biochim Biophys Acta. 2010 Jan;1803(1):55-71 [20080133] Clin Transl Sci. 2008 Dec;1(3):228-39 [20357913] Cancer Res. 2010 Nov 15;70(22):9053-61 [20926399] Clin Cancer Res. 2010 Dec 15;16(24):6132-8 [21037025] J Biol Chem. 2001 Oct 12;276(41):37743-6 [11477090] Cell Mol Life Sci. 2001 Dec;58(14):1969-87 [11814051] EMBO J. 2003 Mar 3;22(5):1114-24 [12606576] Mod Pathol. 2003 Mar;16(3):192-7 [12640097] Am J Surg Pathol. 2003 Nov;27(11):1418-28 [14576474] Lancet. 2003 Nov 15;362(9396):1612-6 [14630441] J Immunol. 2004 Apr 1;172(7):4324-31 [15034047] Int J Cancer. 1994 Apr 1;57(1):90-7 [8150545] Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):136-40 [8552591] Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11531-6 [10500211] Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):1014-20 [16702385] Cancer Cell. 2006 Jul;10(1):39-50 [16843264] Clin Cancer Res. 2006 Aug 1;12(15):4695-701 [16899620] Biochem Biophys Res Commun. 2006 Nov 24;350(3):629-33 [17027649] Gene Ther. 2007 Jun;14(12):921-9 [17377599] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-11-0466 ER - TY - JOUR T1 - Mi-2/NuRD complex function is required for normal S phase progression and assembly of pericentric heterochromatin. AN - 886917840; 21737684 AB - During chromosome duplication, it is essential to replicate not only the DNA sequence, but also the complex nucleoprotein structures of chromatin. Pericentric heterochromatin is critical for silencing repetitive elements and plays an essential structural role during mitosis. However, relatively little is understood about its assembly and maintenance during replication. The Mi2/NuRD chromatin remodeling complex tightly associates with actively replicating pericentric heterochromatin, suggesting a role in its assembly. Here we demonstrate that depletion of the catalytic ATPase subunit CHD4/Mi-2β in cells with a dampened DNA damage response results in a slow-growth phenotype characterized by delayed progression through S phase. Furthermore, we observe defects in pericentric heterochromatin maintenance and assembly. Our data suggest that chromatin assembly defects are sensed by an ATM-dependent intra-S phase chromatin quality checkpoint, resulting in a temporal block to the transition from early to late S phase. These findings implicate Mi-2β in the maintenance of chromatin structure and proper cell cycle progression. JF - Molecular biology of the cell AU - Sims, Jennifer K AU - Wade, Paul A AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 3094 EP - 3102 VL - 22 IS - 17 KW - Autoantigens KW - 0 KW - CHD4 protein, human KW - Cell Cycle Proteins KW - DNA-Binding Proteins KW - Heterochromatin KW - Histones KW - Tumor Suppressor Proteins KW - ATM protein, human KW - EC 2.7.11.1 KW - Ataxia Telangiectasia Mutated Proteins KW - Protein-Serine-Threonine Kinases KW - Mi-2 Nucleosome Remodeling and Deacetylase Complex KW - EC 3.5.1.98 KW - Index Medicus KW - Protein-Serine-Threonine Kinases -- metabolism KW - Humans KW - Autoantigens -- genetics KW - Cell Proliferation KW - S Phase Cell Cycle Checkpoints KW - Cell Cycle Proteins -- metabolism KW - Microscopy, Fluorescence KW - Gene Knockdown Techniques KW - Phosphorylation KW - Histones -- metabolism KW - Tumor Suppressor Proteins -- metabolism KW - RNA Interference KW - Autoantigens -- metabolism KW - Cell Line KW - DNA-Binding Proteins -- metabolism KW - Mi-2 Nucleosome Remodeling and Deacetylase Complex -- metabolism KW - Mi-2 Nucleosome Remodeling and Deacetylase Complex -- genetics KW - Heterochromatin -- metabolism KW - S Phase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/886917840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+biology+of+the+cell&rft.atitle=Mi-2%2FNuRD+complex+function+is+required+for+normal+S+phase+progression+and+assembly+of+pericentric+heterochromatin.&rft.au=Sims%2C+Jennifer+K%3BWade%2C+Paul+A&rft.aulast=Sims&rft.aufirst=Jennifer&rft.date=2011-09-01&rft.volume=22&rft.issue=17&rft.spage=3094&rft.isbn=&rft.btitle=&rft.title=Molecular+biology+of+the+cell&rft.issn=1939-4586&rft_id=info:doi/10.1091%2Fmbc.E11-03-0258 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-30 N1 - Date created - 2011-08-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2003 Jan 30;421(6922):499-506 [12556884] Nat Genet. 2002 Dec;32(4):627-32 [12434153] EMBO J. 2003 Apr 1;22(7):1676-87 [12660173] Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10635-40 [12953102] EMBO J. 2003 Oct 1;22(19):5154-62 [14517253] Mol Cell. 2003 Dec;12(6):1591-8 [14690610] Cell. 2004 Oct 1;119(1):75-86 [15454082] Curr Biol. 1998 Jul 2;8(14):843-6 [9663395] Nat Cell Biol. 2004 Dec;6(12):1236-44 [15543136] Mol Biol Cell. 2005 Jun;16(6):2872-81 [15788566] Biochimie. 2005 Jul;87(7):591-602 [15989976] Nat Cell Biol. 2006 Aug;8(8):870-6 [16862143] Cell. 2007 Feb 23;128(4):721-33 [17320509] Development. 2007 Mar;134(6):1123-32 [17287250] Curr Opin Cell Biol. 2007 Jun;19(3):273-80 [17466503] Mol Biol Cell. 2007 Sep;18(9):3667-80 [17626165] Science. 2007 Dec 21;318(5858):1928-31 [18096807] Nat Chem Biol. 2008 Feb;4(2):119-25 [18176557] Mol Cell. 2008 Apr 11;30(1):61-72 [18406327] Nat Struct Mol Biol. 2008 Sep;15(9):972-9 [19172751] Chromosoma. 2009 Aug;118(4):445-57 [19296121] Mol Biol Cell. 2009 Jul;20(14):3192-9 [19458193] Nat Cell Biol. 2009 Oct;11(10):1261-7 [19734887] Mol Cell. 2010 Mar 12;37(5):736-43 [20227376] J Cell Physiol. 2010 Jun;223(3):667-78 [20333683] Biochim Biophys Acta. 2000 Feb 14;1470(1):O1-8 [10656988] Mol Cell. 2001 Jan;7(1):13-20 [11172707] Nature. 2001 Mar 1;410(6824):116-20 [11242053] Nature. 2001 Mar 1;410(6824):120-4 [11242054] Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000794 [20591991] J Exp Med. 2010 Aug 30;207(9):1939-50 [20733034] J Cell Biol. 2010 Sep 6;190(5):741-9 [20805320] J Cell Biol. 2010 Sep 6;190(5):731-40 [20805324] EMBO J. 2010 Sep 15;29(18):3130-9 [20693977] Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18475-80 [20937877] Nucleic Acids Res. 2010 Nov;38(20):6906-19 [20571081] Genes Dev. 2001 May 1;15(9):1061-6 [11331602] Mol Cell. 2001 Apr;7(4):729-39 [11336697] Science. 2002 Sep 13;297(5588):1871-3 [12077425] Mol Cell. 2003 Feb;11(2):341-51 [12620223] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1091/mbc.E11-03-0258 ER - TY - JOUR T1 - Assessment of the safety and biodistribution of a regulated AAV2 gene transfer vector after delivery to murine submandibular glands. AN - 886917413; 21625005 AB - Clinical gene transfer holds promise for the treatment of many inherited and acquired disorders. A key consideration for all clinical gene transfer applications is the tight control of transgene expression. We have examined the safety and biodistribution of a serotype 2, recombinant adeno-associated viral (AAV2) vector that encodes a rapamycin-responsive chimeric transcription factor, which regulates the expression of a therapeutic transgene (human erythropoietin [hEpo]). The vector, AAV2-TF2.3w-hEpo (2.5 × 10(7)-2.5 × 10(10) particles), was administered once to a single submandibular gland of male and female mice and mediated hEpo expression in vivo following a rapamycin injection but not in its absence. Control (saline treated) and vector-treated animals maintained their weight, and consumed food and water, similarly. Vector delivery led to no significant toxicological effects as judged by hematology, clinical chemistry, and gross and microscopic pathology evaluations. On day 3 after vector delivery, vector copies were not only abundant in the targeted right submandibular gland but also detected in multiple other tissues. Vector was cleared from the targeted gland much more rapidly in female mice than in male mice. Overall, our results are consistent with the notion that administration of the AAV2-TF2.3w-hEpo vector to salivary glands posed no significant risk in mice. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Zheng, Changyu AU - Voutetakis, Antonis AU - Goldstein, Benjamin AU - Afione, Sandra AU - Rivera, Victor M AU - Clackson, Tim AU - Wenk, Martin L AU - Boyle, Molly AU - Nyska, Abraham AU - Chiorini, John A AU - Vallant, Molly AU - Irwin, Richard D AU - Baum, Bruce J AD - Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, 20892, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 247 EP - 255 VL - 123 IS - 1 KW - Erythropoietin KW - 11096-26-7 KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Body Weight KW - Animals KW - Erythropoietin -- blood KW - Sex Factors KW - Sirolimus -- pharmacology KW - Toxicity Tests KW - Erythropoietin -- genetics KW - Mice KW - Mice, Inbred BALB C KW - Male KW - Female KW - Risk Assessment KW - Genetic Vectors -- administration & dosage KW - Submandibular Gland -- virology KW - Submandibular Gland -- metabolism KW - Gene Transfer Techniques -- adverse effects KW - Dependovirus -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/886917413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Assessment+of+the+safety+and+biodistribution+of+a+regulated+AAV2+gene+transfer+vector+after+delivery+to+murine+submandibular+glands.&rft.au=Zheng%2C+Changyu%3BVoutetakis%2C+Antonis%3BGoldstein%2C+Benjamin%3BAfione%2C+Sandra%3BRivera%2C+Victor+M%3BClackson%2C+Tim%3BWenk%2C+Martin+L%3BBoyle%2C+Molly%3BNyska%2C+Abraham%3BChiorini%2C+John+A%3BVallant%2C+Molly%3BIrwin%2C+Richard+D%3BBaum%2C+Bruce+J&rft.aulast=Zheng&rft.aufirst=Changyu&rft.date=2011-09-01&rft.volume=123&rft.issue=1&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfr144 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-20 N1 - Date created - 2011-08-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hum Gene Ther. 1999 Nov 20;10(17):2789-97 [10584925] Methods Mol Biol. 2010;666:3-20 [20717774] Nat Genet. 2000 Mar;24(3):257-61 [10700178] J Virol. 2000 Oct;74(20):9451-63 [11000214] Int Rev Cytol. 2002;213:93-146 [11837896] Blood. 2002 Apr 15;99(8):2670-6 [11929752] J Clin Invest. 2002 Aug;110(4):499-504 [12189244] J Clin Microbiol. 2003 Nov;41(11):5046-52 [14605137] Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3053-8 [14978265] Gene Ther. 2004 Apr;11(8):729-33 [14737095] Gene Ther. 2004 Oct;11(19):1425-6 [15269715] Nature. 1991 Jan 24;349(6307):351-2 [1987492] Am J Physiol. 1994 Jun;266(6 Pt 1):G1146-55 [8023944] Nat Med. 1996 Sep;2(9):1028-32 [8782462] Hum Gene Ther. 1996 Nov 10;7(17):2101-12 [8934224] Hum Gene Ther. 1996 Nov 10;7(17):2177-84 [8934231] Hum Gene Ther. 1998 Dec 10;9(18):2745-60 [9874273] Am J Physiol. 1999 Feb;276(2 Pt 1):E223-32 [9950780] J Virol. 1999 Mar;73(3):1949-55 [9971774] Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8657-62 [10411931] Trends Mol Med. 2004 Dec;10(12):585-90 [15567328] Blood. 2005 Feb 15;105(4):1424-30 [15507527] J Gene Med. 2005 Apr;7(4):432-41 [15515118] J Endocrinol. 2005 Jun;185(3):363-72 [15930162] Gene Ther. 2006 Jan;13(2):187-90 [16177817] Nat Med. 2006 Mar;12(3):342-7 [16474400] Gene Ther. 2006 Apr;13(7):594-601 [16341060] Hum Gene Ther. 2007 Feb;18(2):142-50 [17328682] Hum Gene Ther. 2007 Nov;18(11):1109-18 [17939749] Mol Ther. 2008 Jun;16(6):1089-97 [18388914] J Gene Med. 2009 Jun;11(6):506-14 [19326368] Hum Gene Ther. 2008 Dec;19(12):1401-5 [18764738] J Gene Med. 2010 Jan;12(1):3-10 [19941317] Mol Ther. 2010 Jan;18(1):80-6 [19904234] Gene Ther. 2010 Jan;17(1):50-60 [19759566] Oral Oncol. 2010 Jan;46(1):4-8 [19892587] J Virol. 2000 Mar;74(5):2420-5 [10666273] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfr144 ER - TY - JOUR T1 - Styrene exposure and risk of cancer. AN - 885563199; 21724974 AB - Styrene is widely used in the manufacture of synthetic rubber, resins, polyesters and plastics. Styrene and the primary metabolite styrene-7,8-oxide are genotoxic and carcinogenic. Long-term chemical carcinogenesis bioassays showed that styrene caused lung cancers in several strains of mice and mammary cancers in rats and styrene-7,8-oxide caused tumours of the forestomach in rats and mice and of the liver in mice. Subsequent epidemiologic studies found styrene workers had increased mortality or incidences of lymphohematopoietic cancers (leukaemia or lymphoma or all), with suggestive evidence for pancreatic and esophageal tumours. No adequate human studies are available for styrene-7,8-oxide although this is the primary and active epoxide metabolite of styrene. Both are genotoxic and form DNA adducts in humans. JF - Mutagenesis AU - Huff, James AU - Infante, Peter F AD - National Institute of Environmental Health Sciences, Research Triangle Park, 111 T.W.Alexander Drive, NC 27709, USA. huff1@niehs.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 583 EP - 584 VL - 26 IS - 5 KW - Styrene KW - 44LJ2U959V KW - Index Medicus KW - Humans KW - Male KW - Female KW - Cytogenetic Analysis -- methods KW - DNA Damage KW - Styrene -- toxicity KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885563199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Styrene+exposure+and+risk+of+cancer.&rft.au=Huff%2C+James%3BInfante%2C+Peter+F&rft.aulast=Huff&rft.aufirst=James&rft.date=2011-09-01&rft.volume=26&rft.issue=5&rft.spage=583&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fger033 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-20 N1 - Date created - 2011-08-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann N Y Acad Sci. 1999;895:56-79 [10676409] FASEB J. 2001 Jan;15(1):195-203 [11149907] Ann N Y Acad Sci. 2002 Dec;982:177-89 [12562636] Ann N Y Acad Sci. 2002 Dec;982:208-30 [12562639] IARC Monogr Eval Carcinog Risks Hum. 2002;82:1-556 [12687954] Annu Rev Pharmacol Toxicol. 1979;19:511-30 [378109] Prog Clin Biol Res. 1984;141:227-38 [6718375] Jpn J Cancer Res. 1989 Sep;80(9):795-807 [2513295] Lancet. 1991 Mar 2;337(8740):538-40 [1671901] Environ Health Perspect. 1993 Apr;100:201-10 [8354167] Environ Health Perspect. 1999 Jul;107(7):A341-2 [10405250] Occup Environ Med. 2006 Mar;63(3):157-8 [16497855] Ann Ist Super Sanita. 2006;42(2):113-7 [17033130] Ann N Y Acad Sci. 2006 Sep;1076:1-14 [17119190] Drug Metab Rev. 2006;38(4):805-53 [17145703] J Occup Environ Med. 2009 Nov;51(11):1275-87 [19858749] Occup Environ Med. 2010 May;67(5):341-7 [20447988] Med Lav. 2010 May-Jun;101(3):189-98 [20812660] Occup Environ Med. 2010 Oct;67(10):720 [20837652] Mutagenesis. 2010 Nov;25(6):617-21 [20729469] Environ Health. 2011;10 Suppl 1:S14 [21489210] Science. 2011 May 20;332(6032):916-7 [21596974] Med Lav. 2011 Jul-Aug;102(4):382-3; author reply 383 [21834276] Comment On: Mutagenesis. 2010 Nov;25(6):617-21 [20729469] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/mutage/ger033 ER - TY - JOUR T1 - The resveratrol analogue, 2,3',4,5'-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo[a]pyrene-DNA adduct formation in MCF-7 cells exposed to benzo[a]pyrene. AN - 885563185; 21669939 AB - Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) induces cytochrome P450 (CYP) 1A1 and 1B1 enzymes, which biotransform PAHs resulting in the formation of DNA adducts. We hypothesised that 2,3',4,5'-tetramethoxystilbene (TMS), an analogue of resveratrol and a potent CYP1B1 inhibitor, may inhibit r7, t8, t9-trihydroxy-c-10-(N(2)deoxyguanosyl)-7,8,9,10-tetrahydro-benzo[a]pyrene (BPdG) adduct formation in cells exposed to benzo[a]pyrene (BP). To address this, MCF-7 cells were cultured for 96 h in the presence of 1 μM BP, 1 μM BP + 1 μM TMS or 1 μM BP + 4 μM TMS. Cells were assayed at 2-12 h intervals for: BPdG adducts by r7, t8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE)-DNA chemiluminescence immunoassay; CYP1A1 and 1B1 gene expression changes by relative real-time polymerase chain reaction; and CYP1A1/1B1 enzyme activity by ethoxyresorufin-O-deethylase (EROD) assay. Whereas maximal BPdG levels were similar for all exposure groups, the times at which the maxima were reached increased by 16 and 24 h with the addition of 1 and 4 μM TMS, respectively. The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 μM BP, 1 μM BP + 1 μM TMS or 1 μM BP + 4 μM TMS, respectively. The area under the curve from 4 to 96 h of exposure (AUC(4-)(96 h)) for BPdG adduct formation was not increased in the presence of TMS, but for CYP1A1 and CYP1B1 expression fold increase AUC(4-)(96 h) and EROD-specific activity AUC(4-)(96 h), there were significant (P < 0.05) increases in the presence of 4 μM TMS. Therefore, during 96 h of exposure in MCF-7 cells, the combination of BP plus TMS caused a slowing of BP biotransformation, with an increase in CYP1A1 and CYP1B1 expression and EROD activity, and a slowing, but no change in magnitude of BPdG formation. JF - Mutagenesis AU - Einem Lindeman, Tracey AU - Poirier, Miriam C AU - Divi, Rao L AD - Carcinogen-DNA Interactions Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892-4255, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 629 EP - 635 VL - 26 IS - 5 KW - 2,4,3',5'-tetramethoxystilbene KW - 0 KW - DNA Adducts KW - Stilbenes KW - benzo(a)pyrene-DNA adduct KW - Benzo(a)pyrene KW - 3417WMA06D KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP1B1 protein, human KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP1B1 KW - Index Medicus KW - Cell Survival -- drug effects KW - Biotransformation KW - Humans KW - Up-Regulation -- drug effects KW - Enzyme Activation -- drug effects KW - Up-Regulation -- genetics KW - Cell Line, Tumor KW - Benzo(a)pyrene -- pharmacology KW - Cytochrome P-450 CYP1A1 -- genetics KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Stilbenes -- pharmacology KW - Cytochrome P-450 CYP1A1 -- analysis KW - Aryl Hydrocarbon Hydroxylases -- antagonists & inhibitors KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Gene Expression Regulation, Neoplastic -- drug effects KW - DNA Adducts -- metabolism KW - Benzo(a)pyrene -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885563185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=The+resveratrol+analogue%2C+2%2C3%27%2C4%2C5%27-tetramethoxystilbene%2C+does+not+inhibit+CYP+gene+expression%2C+enzyme+activity+and+benzo%5Ba%5Dpyrene-DNA+adduct+formation+in+MCF-7+cells+exposed+to+benzo%5Ba%5Dpyrene.&rft.au=Einem+Lindeman%2C+Tracey%3BPoirier%2C+Miriam+C%3BDivi%2C+Rao+L&rft.aulast=Einem+Lindeman&rft.aufirst=Tracey&rft.date=2011-09-01&rft.volume=26&rft.issue=5&rft.spage=629&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fger024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-20 N1 - Date created - 2011-08-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2000 Feb 15;60(4):908-15 [10706104] IARC Monogr Eval Carcinog Risks Hum. 2010;92:1-853 [21141735] Cell Mol Life Sci. 2002 Apr;59(4):665-81 [12022473] Carcinogenesis. 2002 Dec;23(12):2043-9 [12507927] Mutat Res. 2003 Jan;543(1):17-30 [12510015] Med Res Rev. 2003 Nov;23(6):657-68 [12939788] Cancer Sci. 2004 Jan;95(1):1-6 [14720319] Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):500-9 [14751521] Carcinogenesis. 2004 Oct;25(10):2005-13 [15142886] Science. 1976 Aug 13;193(4253):592-5 [959820] Nature. 1983 Jun 9-15;303(5917):468-72 [6304528] Mol Cell Biol. 1986 May;6(5):1471-7 [3785172] Carcinogenesis. 1990 Jul;11(7):1241-3 [2372884] Cancer Epidemiol Biomarkers Prev. 1993 Jul-Aug;2(4):341-7 [8348057] Ann N Y Acad Sci. 1993 Jun 23;685:624-40 [8395783] Cancer Res. 1995 Mar 1;55(5):1039-44 [7866986] Annu Rev Pharmacol Toxicol. 1995;35:307-40 [7598497] J Biol Chem. 1995 Aug 4;270(31):18175-8 [7629130] Cancer Epidemiol Biomarkers Prev. 1995 Jun;4(4):341-6 [7655328] Cancer Res. 1996 Jul 1;56(13):2979-84 [8674051] Cancer Res. 1997 Jul 15;57(14):3026-31 [9230218] Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10937-42 [9380738] Eur J Cancer. 1998 Apr;34(5):757-8 [9713287] Drug Metab Rev. 1999 May;31(2):437-47 [10335446] Chem Res Toxicol. 1999 Jul;12(7):623-9 [10409402] Mol Pharmacol. 1999 Oct;56(4):784-90 [10496962] Ann N Y Acad Sci. 2004 Dec;1028:247-57 [15650250] Drug Metab Dispos. 2005 Dec;33(12):1771-6 [16120791] Future Oncol. 2005 Apr;1(2):259-63 [16555997] Chem Res Toxicol. 2007 Mar;20(3):424-31 [17295519] Bioorg Med Chem. 2007 Aug 1;15(15):5047-60 [17544277] Cancer Res. 2007 Jun 15;67(12):5717-26 [17575138] Carcinogenesis. 2007 Jul;28(7):1426-9 [17277232] J Biochem Mol Toxicol. 2007;21(3):101-9 [17623886] J Steroid Biochem Mol Biol. 2007 Jun-Jul;105(1-5):150-8 [17582757] Mutagenesis. 2008 Jan;23(1):1-18 [17989146] Cancer Prev Res (Phila). 2008 Jul;1(2):135-45 [19138946] Future Oncol. 2010 Jan;6(1):75-91 [20021210] Cancer Res. 2001 Nov 15;61(22):8164-70 [11719446] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/mutage/ger024 ER - TY - JOUR T1 - Transformation frequency of a mariner-based transposon in Rickettsia rickettsii. AN - 885562668; 21764933 AB - Transformation frequencies of a mariner-based transposon system in Rickettsia rickettsii were determined using a plaque assay system for enumeration and isolation of mutants. Sequence analysis of insertion sites in both R. rickettsii and R. prowazekii indicated that insertions were random. Transposon mutagenesis provides a useful tool for rickettsial research. Copyright © 2011, American Society for Microbiology. All Rights Reserved. JF - Journal of bacteriology AU - Clark, Tina R AU - Lackey, Amanda M AU - Kleba, Betsy AU - Driskell, Lonnie O AU - Lutter, Erika I AU - Martens, Craig AU - Wood, David O AU - Hackstadt, Ted AD - Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 598401, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 4993 EP - 4995 VL - 193 IS - 18 KW - DNA Transposable Elements KW - 0 KW - DNA, Bacterial KW - Index Medicus KW - Viral Plaque Assay KW - DNA, Bacterial -- genetics KW - Mutagenesis, Insertional KW - Rickettsia prowazekii -- genetics KW - Rickettsia rickettsii -- genetics KW - Transformation, Genetic KW - DNA Transposable Elements -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885562668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Transformation+frequency+of+a+mariner-based+transposon+in+Rickettsia+rickettsii.&rft.au=Clark%2C+Tina+R%3BLackey%2C+Amanda+M%3BKleba%2C+Betsy%3BDriskell%2C+Lonnie+O%3BLutter%2C+Erika+I%3BMartens%2C+Craig%3BWood%2C+David+O%3BHackstadt%2C+Ted&rft.aulast=Clark&rft.aufirst=Tina&rft.date=2011-09-01&rft.volume=193&rft.issue=18&rft.spage=4993&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=1098-5530&rft_id=info:doi/10.1128%2FJB.05279-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-27 N1 - Date created - 2011-08-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Bacteriol. 2000 Jun;182(11):3289-91 [10809714] Infect Immun. 2011 Apr;79(4):1631-7 [21300770] Appl Environ Microbiol. 2004 May;70(5):2816-22 [15128537] J Bacteriol. 1969 Sep;99(3):910-2 [4984178] Appl Microbiol. 1974 Jun;27(6):1157-61 [4208640] Infect Immun. 1975 Jun;11(6):1391-404 [806528] Appl Microbiol. 1975 Sep;30(3):456-63 [810089] Infect Immun. 1976 Oct;14(4):1052-64 [825463] Annu Rev Microbiol. 1982;36:345-70 [6756292] Annu Rev Microbiol. 1986;40:287-309 [3096192] J Clin Microbiol. 1987 Jan;25(1):167-71 [2432081] FEMS Microbiol Lett. 1991 Jul 1;65(3):341-4 [1916232] Res Microbiol. 1992 Nov-Dec;143(9):821-9 [1299836] Infect Immun. 1993 May;61(5):1926-35 [8478082] Infect Agents Dis. 1996 Jun;5(3):127-43 [8805076] J Clin Microbiol. 1996 Aug;34(8):1944-8 [8818887] Emerg Infect Dis. 1998 Apr-Jun;4(2):179-86 [9621188] Clin Microbiol Rev. 2005 Oct;18(4):719-56 [16223955] Appl Environ Microbiol. 2007 Oct;73(20):6644-9 [17720821] Infect Immun. 2008 Feb;76(2):542-50 [18025092] Infect Immun. 2009 Aug;77(8):3244-8 [19506016] Infect Immun. 2010 May;78(5):2240-7 [20194597] Science. 2001 Sep 14;293(5537):2093-8 [11557893] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JB.05279-11 ER - TY - JOUR T1 - Medical history and the risk of biliary tract cancers in Shanghai, China: implications for a role of inflammation AN - 885057109; 15397681 AB - Several lines of evidence suggest that inflammation may play a role in the etiology of biliary tract cancers. To examine further the role of inflammation, we evaluated the associations between self-reported inflammatory-related medical conditions and the risk of biliary tract cancers in a population-based case-control study in Shanghai, China. Our analysis included 368 gallbladder cancer cases, 191 bile duct cancer cases, 68 ampulla of Vater cancer cases, and 959 healthy subjects. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for biliary tract cancers in relation to six inflammation-related conditions. Gallbladder cancer was significantly associated with cholecystitis occurring at least 5 years prior to interview (OR = 1.7, 95% CI 1.1-2.9). Even though biliary stones did not significantly modify the associations between cholecystitis and gallbladder cancer, 90% of the gallbladder cancer cases with cholecystitis also had biliary stones, indicating that stones likely play an important role in the link between cholecystitis and gallbladder cancer. Among subjects who smoked and drank alcohol, a history of gastric (OR = 4.3, 95% CI 1.2-15.0) or duodenal ulcers (OR = 3.7, 1.2-12.0) was associated with an excess risk of gallbladder cancer. Although the mechanisms are unclear, our results further support the role for inflammation in the etiology of biliary tract cancers. JF - Cancer Causes & Control AU - Andreotti, Gabriella AU - Liu, Enju AU - Gao, Yu-Tang AU - Safaeian, Mahboobeh AU - Rashid, Asif AU - Shen, Ming-Chang AU - Wang, Bin-Shen AU - Deng, Jie AU - Han, Tian-Quian AU - Zhang, Bai-He AU - Hsing, Ann W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., EPS 8011, MSC 7240, Bethesda, MD, 20892, USA, andreotg@mail.nih.gov andreotg@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1289 EP - 1296 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 22 IS - 9 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Historical account KW - Alcohol KW - Etiology KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885057109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Medical+history+and+the+risk+of+biliary+tract+cancers+in+Shanghai%2C+China%3A+implications+for+a+role+of+inflammation&rft.au=Andreotti%2C+Gabriella%3BLiu%2C+Enju%3BGao%2C+Yu-Tang%3BSafaeian%2C+Mahboobeh%3BRashid%2C+Asif%3BShen%2C+Ming-Chang%3BWang%2C+Bin-Shen%3BDeng%2C+Jie%3BHan%2C+Tian-Quian%3BZhang%2C+Bai-He%3BHsing%2C+Ann+W&rft.aulast=Andreotti&rft.aufirst=Gabriella&rft.date=2011-09-01&rft.volume=22&rft.issue=9&rft.spage=1289&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9802-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Alcohol; Historical account; Etiology; Cancer; China, People's Rep., Shanghai; China, People's Rep. DO - http://dx.doi.org/10.1007/s10552-011-9802-z ER - TY - JOUR T1 - Lactate dehydrogenase C and energy metabolism in mouse sperm. AN - 885055412; 21565994 AB - We demonstrated previously that disruption of the germ cell-specific lactate dehydrogenase C gene (Ldhc) led to male infertility due to defects in sperm function, including a rapid decline in sperm ATP levels, a decrease in progressive motility, and a failure to develop hyperactivated motility. We hypothesized that lack of LDHC disrupts glycolysis by feedback inhibition, either by causing a defect in renewal of the NAD(+) cofactor essential for activity of glyceraldehyde 3-phosphate dehydrogenase, sperm (GAPDHS), or an accumulation of pyruvate. To test these hypotheses, nuclear magnetic resonance analysis was used to follow the utilization of labeled substrates in real time. We found that in sperm lacking LDHC, glucose consumption was disrupted, but the NAD:NADH ratio and pyruvate levels were unchanged, and pyruvate was rapidly metabolized to lactate. Moreover, the metabolic disorder induced by treatment with the lactate dehydrogenase (LDH) inhibitor sodium oxamate was different from that caused by lack of LDHC. This supported our earlier conclusion that LDHA, an LDH isozyme present in the principal piece of the flagellum, is responsible for the residual LDH activity in sperm lacking LDHC, but suggested that LDHC has an additional role in the maintenance of energy metabolism in sperm. By coimmunoprecipitation coupled with mass spectrometry, we identified 27 proteins associated with LDHC. A majority of these proteins are implicated in ATP synthesis, utilization, transport, and/or sequestration. This led us to hypothesize that in addition to its role in glycolysis, LDHC is part of a complex involved in ATP homeostasis that is disrupted in sperm lacking LDHC. JF - Biology of reproduction AU - Odet, Fanny AU - Gabel, Scott A AU - Williams, Jason AU - London, Robert E AU - Goldberg, Erwin AU - Eddy, Edward M AD - Laboratories of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709-2233, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 556 EP - 564 VL - 85 IS - 3 KW - Carbon Isotopes KW - 0 KW - Isoenzymes KW - NAD KW - 0U46U6E8UK KW - Pyruvic Acid KW - 8558G7RUTR KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - lactate dehydrogenase C4 KW - EC 1.1.1.27.- KW - Glucose KW - IY9XDZ35W2 KW - Oxamic Acid KW - QU60N5OPLG KW - Index Medicus KW - Animals KW - Mass Spectrometry KW - Glucose -- metabolism KW - Immunoprecipitation KW - Mice KW - Isoenzymes -- metabolism KW - Membrane Potential, Mitochondrial KW - Mice, Knockout KW - Magnetic Resonance Spectroscopy KW - Isoenzymes -- antagonists & inhibitors KW - NAD -- metabolism KW - Adenosine Triphosphate -- metabolism KW - Carbon Isotopes -- analysis KW - Pyruvic Acid -- metabolism KW - Male KW - Spermatozoa -- metabolism KW - L-Lactate Dehydrogenase -- antagonists & inhibitors KW - Glycolysis KW - L-Lactate Dehydrogenase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885055412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+reproduction&rft.atitle=Lactate+dehydrogenase+C+and+energy+metabolism+in+mouse+sperm.&rft.au=Odet%2C+Fanny%3BGabel%2C+Scott+A%3BWilliams%2C+Jason%3BLondon%2C+Robert+E%3BGoldberg%2C+Erwin%3BEddy%2C+Edward+M&rft.aulast=Odet&rft.aufirst=Fanny&rft.date=2011-09-01&rft.volume=85&rft.issue=3&rft.spage=556&rft.isbn=&rft.btitle=&rft.title=Biology+of+reproduction&rft.issn=1529-7268&rft_id=info:doi/10.1095%2Fbiolreprod.111.091546 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-12 N1 - Date created - 2011-08-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Reprod Fertil. 2000 Jan;118(1):127-35 [10793634] Int J Biochem Cell Biol. 2010 May;42(5):623-9 [20060930] J Biol Chem. 2001 Mar 9;276(10):7630-6 [11115497] J Androl. 2001 Jul-Aug;22(4):680-95 [11451366] Reproduction. 2003 Jan;125(1):17-26 [12622692] FEBS Lett. 2003 Nov 20;554(3):342-6 [14623091] Biol Reprod. 2004 Aug;71(2):540-7 [15084484] Diabetes. 1967 Apr;16(4):252-8 [4290244] J Exp Zool. 1970 Jun;174(2):173-86 [4393121] J Anim Sci. 1976 Jul;43(1):159-63 [939721] J Biol Chem. 1978 Dec 10;253(23):8465-9 [711761] Cell Biochem Funct. 1984 Jul;2(3):131-4 [6383647] Biol Reprod. 1985 Jun;32(5):1201-10 [2410040] Biol Reprod. 1986 Mar;34(2):349-56 [3082381] Biol Reprod. 1989 Jan;40(1):173-80 [2923949] Exp Clin Immunogenet. 1985;2(2):120-4 [2856184] J Theor Biol. 1991 Sep 7;152(1):103-7 [1753751] Biol Reprod. 1996 Oct;55(4):917-22 [8879509] J Cell Sci. 1997 Aug;110 ( Pt 15):1821-9 [9264469] Biol Reprod. 1997 Oct;57(4):791-5 [9314582] Mol Reprod Dev. 1998 Apr;49(4):374-85 [9508088] Methods. 1999 Oct;19(2):306-21 [10527733] Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16501-6 [15546993] Stem Cells. 2005 Oct;23(9):1314-23 [16051982] Hum Reprod Update. 2006 May-Jun;12(3):269-74 [16407453] Proteins. 2006 May 15;63(3):501-11 [16444750] J Androl. 2006 Jul-Aug;27(4):502-9 [16582413] Biol Reprod. 2006 Aug;75(2):270-8 [16687649] Biol Reprod. 2006 Nov;75(5):767-77 [16855207] Dev Biol. 2007 Feb 15;302(2):463-76 [17137571] Soc Reprod Fertil Suppl. 2007;65:309-25 [17644971] J Biol Chem. 2007 Oct 5;282(40):29658-66 [17681941] Biol Reprod. 2008 Jul;79(1):26-34 [18367675] Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17718-23 [19008351] Reproduction. 2009 Sep;138(3):463-70 [19556438] Biol Reprod. 2010 Jan;82(1):136-45 [19759366] Biol Reprod. 2010 Mar;82(3):504-15 [19889946] Biol Reprod. 2001 May;64(5):1350-7 [11319138] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1095/biolreprod.111.091546 ER - TY - JOUR T1 - Magnetic resonance imaging quantification of regional cerebral blood flow and cerebrovascular reactivity to carbon dioxide in normotensive and hypertensive rats AN - 885052034; 15458429 AB - Hypertension afflicts 25% of the general population and over 50% of the elderly. In the present work, arterial spin labeling MRI was used to non-invasively quantify regional cerebral blood flow (CBF), cerebrovascular resistance and CO sub(2 reactivity in spontaneously hypertensive rats (SHR) and in normotensive Wistar Kyoto rats (WKY), at two different ages (3 months and 10 months) and under the effects of two anesthetics, alpha -chloralose and 2% isoflurane (1.5 MAC). Repeated CBF measurements were highly consistent, differing by less than 10% and 18% within and across animals, respectively. Under alpha -chloralose, whole brain CBF at normocapnia did not differ between groups (young WKY: 61 +/- 3 ml/100 g/min; adult WKY: 62 +/- 4 ml/100 g/min; young SHR: 70 +/- 9 ml/100 g/min; adult SHR: 69 +/- 8 ml/100 g/min), indicating normal cerebral autoregulation in SHR. At hypercapnia, CBF values increased significantly, and a linear relationship between CBF and PaCO) sub(2) levels was observed. In contrast, 2% isoflurane impaired cerebral autoregulation. Whole brain CBF in SHR was significantly higher than in WKY rats at normocapnia (young SHR: 139 +/- 25 ml/100 g/min; adult SHR: 104 +/- 23 ml/100 g/min; young WKY: 55 +/- 9 ml/100 g/min; adult WKY: 71 +/- 19 ml/100 g/min). CBF values increased significantly with increasing CO sub(2; however, there was a clear saturation of CBF at PaCO) sub(2) levels greater than 70 mm Hg in both young and adult rats, regardless of absolute CBF values, suggesting that isoflurane interferes with the vasodilatory mechanisms of CO sub(2. This behavior was observed for both cortical and subcortical structures. Under either anesthetic, CO) sub(2) reactivity values in adult SHR were decreased, confirming that hypertension, when combined with age, increases cerebrovascular resistance and reduces cerebrovascular compliance. JF - NeuroImage AU - Leoni, Renata F AU - Paiva, Fernando F AU - Henning, Erica C AU - Nascimento, George C AU - Tannus, Alberto AU - De Araujo, Draulio B AU - Silva, Afonso C Y1 - 2011/09/01/ PY - 2011 DA - 2011 Sep 01 SP - 75 EP - 81 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 58 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Age KW - Cerebral blood flow KW - W 30910:Imaging KW - N3:11027 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885052034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Magnetic+resonance+imaging+quantification+of+regional+cerebral+blood+flow+and+cerebrovascular+reactivity+to+carbon+dioxide+in+normotensive+and+hypertensive+rats&rft.au=Leoni%2C+Renata+F%3BPaiva%2C+Fernando+F%3BHenning%2C+Erica+C%3BNascimento%2C+George+C%3BTannus%2C+Alberto%3BDe+Araujo%2C+Draulio+B%3BSilva%2C+Afonso+C&rft.aulast=Leoni&rft.aufirst=Renata&rft.date=2011-09-01&rft.volume=58&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2011.06.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Cerebral blood flow DO - http://dx.doi.org/10.1016/j.neuroimage.2011.06.030 ER - TY - JOUR T1 - Infratentorial craniospinal irradiation for von Hippel-Lindau: a retrospective study supporting a new treatment for patients with CNS hemangioblastomas. AN - 884426223; 21798886 AB - Patients with von Hippel-Lindau (VHL) syndrome with diffuse CNS hemangioblastomas have morbidity related to their disease and require a lifetime of surgical resections. Ninety-seven percent of tumors progress, and 5-year surgery rates are 20%-60%. Stereotactic radiosurgery and fractionated radiotherapy have had limited success. For the first time, we have used infratentorial craniospinal radiation therapy (ICSRT) for VHL patients with CNS hemangioblastomas. Consecutive VHL patients treated at the National Institutes of Health with radiographic evidence of hemangioblastomas were included if they received ICSRT. Patients underwent neurologic examinations and imaging at 3- to 12-month intervals. Seven patients with 84 hemangioblastomas met eligibility criteria. ICSRT was commonly administered to 43.2 Gy in 24 fractions. Mean pre-ICSRT tumor volume was 5.48 cm(3). At a mean follow-up of 73.8 months, mean post-ICSRT tumor volume was 6.87 cm(3), and 91 tumors were identified. Complete radiographic resolution was achieved in 17.9% of lesions. Although many patients were no longer optimal surgical candidates, only 4 surgeries were needed for symptomatic lesions after ICSRT, compared with 33 prior. Acute toxicity was mild and no patient developed grade ≥1 late spinal cord toxicity according to the criteria of the Radiation Therapy Oncology Group/European Organisation for Research and Treatment of Cancer, despite the high dose that the entire spinal cord received. Clinical and radiographic stability or resolution was demonstrated in the majority of tumors. Tumor growth rate in this study was less than reported in natural history studies, and the rate of surgical intervention was reduced. ICSRT was well tolerated, can decrease hemangioblastoma growth rate, and is a potential therapeutic option for VHL patients that warrants further investigation. JF - Neuro-oncology AU - Simone, Charles B AU - Lonser, Russell R AU - Ondos, John AU - Oldfield, Edward H AU - Camphausen, Kevin AU - Simone, Nicole L AD - National Institutes of Health, National Cancer Institute, Radiation Oncology Branch, Bethesda, MD 20892, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 1030 EP - 1036 VL - 13 IS - 9 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Survival Rate KW - Combined Modality Therapy KW - Humans KW - Adult KW - Treatment Outcome KW - Retrospective Studies KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Spinal Cord Neoplasms -- radiotherapy KW - Hemangioblastoma -- etiology KW - Hemangioblastoma -- surgery KW - Cranial Irradiation KW - von Hippel-Lindau Disease -- radiotherapy KW - Spinal Cord Neoplasms -- etiology KW - Infratentorial Neoplasms -- radiotherapy KW - Spinal Cord Neoplasms -- surgery KW - Infratentorial Neoplasms -- surgery KW - Hemangioblastoma -- radiotherapy KW - Infratentorial Neoplasms -- etiology KW - Cerebellar Neoplasms -- etiology KW - Cerebellar Neoplasms -- radiotherapy KW - Cerebellar Neoplasms -- surgery KW - von Hippel-Lindau Disease -- surgery KW - von Hippel-Lindau Disease -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/884426223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuro-oncology&rft.atitle=Infratentorial+craniospinal+irradiation+for+von+Hippel-Lindau%3A+a+retrospective+study+supporting+a+new+treatment+for+patients+with+CNS+hemangioblastomas.&rft.au=Simone%2C+Charles+B%3BLonser%2C+Russell+R%3BOndos%2C+John%3BOldfield%2C+Edward+H%3BCamphausen%2C+Kevin%3BSimone%2C+Nicole+L&rft.aulast=Simone&rft.aufirst=Charles&rft.date=2011-09-01&rft.volume=13&rft.issue=9&rft.spage=1030&rft.isbn=&rft.btitle=&rft.title=Neuro-oncology&rft.issn=1523-5866&rft_id=info:doi/10.1093%2Fneuonc%2Fnor085 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-08 N1 - Date created - 2011-08-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Radiat Oncol Biol Phys. 1990 May;18(5):1165-71 [2347723] J Neurosurg. 1989 Jan;70(1):24-30 [2909683] Radiology. 1995 Mar;194(3):629-42 [7862955] J Neurosurg. 2006 Aug;105(2):248-55 [17219830] Clin Neurosurg. 2006;53:324-31 [17380770] Int J Radiat Oncol Biol Phys. 2007 Dec 1;69(5):1521-6 [17869023] Neurosurgery. 2001 Aug;49(2):321-7; discussion 327-8 [11504107] Neurosurgery. 2001 Jan;48(1):55-62; discussion 62-3 [11152361] Neuro Oncol. 2010 Jan;12(1):80-6 [20150370] J Neurosurg. 2003 Jan;98(1):82-94 [12546356] J Neurosurg. 2003 Jan;98(1):95-105 [12546357] J Neurosurg. 2003 Jan;98(1):106-16 [12546358] AJNR Am J Neuroradiol. 2003 Sep;24(8):1570-4 [13679272] Cancer Res. 2003 Nov 1;63(21):7051-5 [14612494] Neurosurgery. 2003 Dec;53(6):1306-13; discussion 1313-4 [14633297] Cancer. 1982 Feb 1;49(3):553-5 [7199372] Surg Neurol. 1986 Mar;25(3):269-75 [3945908] Int J Radiat Oncol Biol Phys. 1993 Jan 15;25(2):381-5 [8420891] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/neuonc/nor085 ER - TY - JOUR T1 - Biweekly rituximab, cyclophosphamide, vincristine, non-pegylated liposome-encapsulated doxorubicin and prednisone (R-COMP-14) in elderly patients with poor-risk diffuse large B-cell lymphoma and moderate to high 'life threat' impact cardiopathy. AN - 883310588; 21707585 AB - This Phase II study assessed feasibility and efficacy of a biweekly R-COMP-14 regimen (rituximab, cyclophosphamide, non-pegylated liposome-encapsulated doxorubicin, vincristine and prednisone) in untreated elderly patients with poor-risk diffuse large B-cell lymphoma (DLBCL) and moderate to high 'life threat' impact NIA/NCI cardiac comorbidity. A total of 208 courses were delivered, with close cardiac monitoring, to 41 patients (median age: 73years, range: 62-82; 37% >75years) at a median interval of 15·6 (range, 13-29) days; 67% completed all six scheduled courses. Response rate was 73%, with 68% complete responses (CR); 4-year disease-free survival (DFS) and time to treatment failure (TTF) were 72% and 49%, respectively. Failures were due to early death (n=3), therapy discontinuations (no-response n=2; toxicity n=6), relapse (n=6) and death in CR (n=3). Incidence of cardiac grade 3-5 adverse events was 7/41 (17%; 95% confidence interval: 8-31%). Time to progression and overall survival at 4-years were 77% and 67%, respectively. The Age-adjusted Charlson Comorbidity Index (aaCCI) correlated with failures (P=0·007) with patients scoring ≤7 having a longer TTF (66% vs. 29%; P=0·009). R-COMP-14 is feasible and ensures a substantial DFS to poor-risk DLBCL patients who would have been denied anthracycline-based treatment due to cardiac morbidity. The aaCCI predicted both treatment discontinuation rate and TTF. © 2011 Blackwell Publishing Ltd. JF - British journal of haematology AU - Corazzelli, Gaetano AU - Frigeri, Ferdinando AU - Arcamone, Manuela AU - Lucania, Anna AU - Rosariavilla, Maria AU - Morelli, Emanuela AU - Amore, Alfonso AU - Capobianco, Gaetana AU - Caronna, Antonietta AU - Becchimanzi, Cristina AU - Volzone, Francesco AU - Marcacci, Gianpaolo AU - Russo, Filippo AU - De Filippi, Rosaria AU - Mastrullo, Lucia AU - Pinto, Antonio AD - Haematology-Oncology and Stem Cell Transplantation Unit, National Cancer Institute, Fondazione G. Pascale, IRCCS, Naples, Italy. g.corazzelli@istitutotumori.na.it Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 579 EP - 589 VL - 154 IS - 5 KW - Antibodies, Monoclonal, Murine-Derived KW - 0 KW - liposomal doxorubicin KW - Polyethylene Glycols KW - 30IQX730WE KW - Rituximab KW - 4F4X42SYQ6 KW - Vincristine KW - 5J49Q6B70F KW - Doxorubicin KW - 80168379AG KW - Cyclophosphamide KW - 8N3DW7272P KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Doxorubicin -- analogs & derivatives KW - Humans KW - Vincristine -- administration & dosage KW - Prognosis KW - Aged KW - Doxorubicin -- administration & dosage KW - Polyethylene Glycols -- administration & dosage KW - Comorbidity KW - Risk KW - Aged, 80 and over KW - Antibodies, Monoclonal, Murine-Derived -- administration & dosage KW - Treatment Outcome KW - Middle Aged KW - Prednisone -- administration & dosage KW - Female KW - Male KW - Survival Analysis KW - Lymphoma, Large B-Cell, Diffuse -- complications KW - Heart Diseases -- epidemiology KW - Heart Diseases -- drug therapy KW - Lymphoma, Large B-Cell, Diffuse -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883310588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+haematology&rft.atitle=Biweekly+rituximab%2C+cyclophosphamide%2C+vincristine%2C+non-pegylated+liposome-encapsulated+doxorubicin+and+prednisone+%28R-COMP-14%29+in+elderly+patients+with+poor-risk+diffuse+large+B-cell+lymphoma+and+moderate+to+high+%27life+threat%27+impact+cardiopathy.&rft.au=Corazzelli%2C+Gaetano%3BFrigeri%2C+Ferdinando%3BArcamone%2C+Manuela%3BLucania%2C+Anna%3BRosariavilla%2C+Maria%3BMorelli%2C+Emanuela%3BAmore%2C+Alfonso%3BCapobianco%2C+Gaetana%3BCaronna%2C+Antonietta%3BBecchimanzi%2C+Cristina%3BVolzone%2C+Francesco%3BMarcacci%2C+Gianpaolo%3BRusso%2C+Filippo%3BDe+Filippi%2C+Rosaria%3BMastrullo%2C+Lucia%3BPinto%2C+Antonio&rft.aulast=Corazzelli&rft.aufirst=Gaetano&rft.date=2011-09-01&rft.volume=154&rft.issue=5&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=British+journal+of+haematology&rft.issn=1365-2141&rft_id=info:doi/10.1111%2Fj.1365-2141.2011.08786.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-27 N1 - Date created - 2011-08-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 2007 May 10;25(14):1916-23 [17488991] Ann Oncol. 2011 Feb;22(2):257-67 [20956616] Hematol Oncol. 2007 Dec;25(4):198-203 [17654614] Lancet Oncol. 2008 Feb;9(2):105-16 [18226581] Clin Lymphoma Myeloma. 2007 Dec;8 Suppl 2:S43-9 [18284715] Hematol Oncol. 2008 Mar;26(1):27-32 [17868190] Ann Oncol. 2008 Apr;19(4):774-9 [18065404] Clin Res Cardiol. 2008 May;97(5):318-26 [18193371] Exp Oncol. 2008 Jun;30(2):160-2 [18566583] Leuk Lymphoma. 2008 Jun;49(6):1081-6 [18569635] J Clin Oncol. 2008 Jul 1;26(19):3159-65 [18591554] J Clin Oncol. 2009 Jan 1;27(1):127-45 [19018081] Lancet Oncol. 2009 Apr;10(4):391-9 [19341970] Intensive Care Med. 2000 Jan;26(1):31-7 [10663277] Clin Chem. 2000 May;46(5):650-7 [10794747] J Clin Oncol. 2001 Mar 1;19(5):1444-54 [11230490] Intensive Care Med. 2001 Jun;27(6):965-9 [11497154] Br J Cancer. 2002 Jun 5;86(11):1697-700 [12087452] Anticancer Res. 2002 May-Jun;22(3):1845-8 [12168880] Ann Oncol. 2003 Feb;14(2):277-81 [12562656] Circulation. 2003 Sep 2;108(9):1146-62 [12952829] Circulation. 2003 Sep 16;108(11):1404-18 [12975245] Cancer Control. 2003 Sep-Oct;10(5):396-403 [14581895] J Clin Oncol. 2004 Mar 1;22(5):769-73 [14990630] J Clin Oncol. 2004 Jul 1;22(13):2662-70 [15226333] Blood. 2004 Aug 1;104(3):634-41 [15016643] Curr Cardiol Rep. 2004 Sep;6(5):379-84 [15306095] N Engl J Med. 2004 Sep 9;351(11):1053-6 [15356302] J Chronic Dis. 1987;40(5):373-83 [3558716] Am J Med. 1987 Jun;82(6):1109-18 [3605130] N Engl J Med. 1993 Sep 30;329(14):987-94 [8141877] Biometrics. 1995 Dec;51(4):1372-83 [8589229] Cancer. 1998 Jun 1;82(11):2123-34 [9610691] Am J Emerg Med. 1999 May;17(3):225-9 [10337875] Lancet Oncol. 2004 Nov;5(11):654 [15522651] BMC Cancer. 2004 Dec 20;4:94 [15610554] Semin Oncol. 2004 Dec;31(6 Suppl 13):5-15 [15717735] Br J Haematol. 2005 Jun;129(5):597-606 [15916681] J Clin Oncol. 2005 Jun 20;23(18):4117-26 [15867204] Ann Oncol. 2006 Jun;17(6):928-34 [16507563] Semin Oncol. 2006 Jun;33(3 Suppl 8):S2-7 [16781283] Semin Oncol. 2006 Jun;33(3 Suppl 8):S22-7 [16781286] Cancer. 2006 Oct 1;107(7):1530-41 [16933332] Leuk Lymphoma. 2006 Oct;47(10):2174-80 [17071492] Circulation. 2006 Dec 5;114(23):2474-81 [17101852] J Clin Oncol. 2007 Feb 10;25(5):579-86 [17242396] Cancer Chemother Pharmacol. 2009 Oct;64(5):907-16 [19219604] J Natl Cancer Inst. 2010 Jan 6;102(1):14-25 [20007921] Leuk Lymphoma. 2010 May;51(5):737-8 [20367567] J Clin Oncol. 2010 May 10;28(14):2373-80 [20385988] Ann Oncol. 2010 Jul;21(7):1492-9 [20007997] Ann Hematol. 2010 Sep;89(9):897-904 [20414658] Blood. 2007 Aug 1;110(3):972-8 [17400912] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2141.2011.08786.x ER - TY - JOUR T1 - Comparative toxicology of mercurials in Caenorhabditis elegans. AN - 883307091; 21692103 AB - Mercury (Hg) is a toxic metal that can exist in multiple chemical species. Humans are commonly exposed to methylmercury and Hg vapor, which are converted to mercuric species in the body. Despite years of research, little information exists on the similarities and differences in the mechanisms of Hg toxicity. The relative toxicity of mercuric chloride (HgCl(2)) and methylmercury chloride (MeHgCl) in Caenorhabditis elegans was determined in assays that measured growth, feeding, reproduction, and locomotion. The effect of HgCl(2) and MeHgCl on the expression of several archetypal stress-response genes was also determined. There was no significant difference between the EC50s of the two mercurials in terms of C. elegans growth. However, MeHgCl was more toxic to C. elegans than HgCl(2) when assessing feeding, movement, and reproduction, all of which require proper neuromuscular activity. Methylmercury chloride exposure resulted in increased steady-state levels of the stress response genes at lower concentrations than HgCl(2). In general, MeHgCl was more toxic to C. elegans than HgCl(2), particularly when assaying behaviors that require neuromuscular function. Copyright © 2011 SETAC. JF - Environmental toxicology and chemistry AU - McElwee, Matthew K AU - Freedman, Jonathan H AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 2135 EP - 2141 VL - 30 IS - 9 KW - Caenorhabditis elegans Proteins KW - 0 KW - Methylmercury Compounds KW - RNA, Messenger KW - Water Pollutants, Chemical KW - methylmercuric chloride KW - RWZ4L3O1X0 KW - Index Medicus KW - Gene Expression -- drug effects KW - Behavior, Animal -- drug effects KW - Animals KW - RNA, Messenger -- metabolism KW - Caenorhabditis elegans Proteins -- genetics KW - Reproduction -- drug effects KW - Caenorhabditis elegans -- growth & development KW - Caenorhabditis elegans -- drug effects KW - Water Pollutants, Chemical -- toxicity KW - Caenorhabditis elegans -- metabolism KW - Methylmercury Compounds -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883307091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Comparative+toxicology+of+mercurials+in+Caenorhabditis+elegans.&rft.au=McElwee%2C+Matthew+K%3BFreedman%2C+Jonathan+H&rft.aulast=McElwee&rft.aufirst=Matthew&rft.date=2011-09-01&rft.volume=30&rft.issue=9&rft.spage=2135&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.603 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-27 N1 - Date created - 2011-08-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Methods Mol Biol. 2000;132:365-86 [10547847] Toxicol Sci. 2010 Dec;118(2):613-24 [20855423] Cell Biol Toxicol. 2000;16(6):347-62 [11254161] Methods. 2001 Dec;25(4):402-8 [11846609] Toxicol Sci. 2002 Apr;66(2):261-73 [11896293] Prog Mol Subcell Biol. 2002;28:61-78 [11908066] Cell Calcium. 2003 Sep;34(3):285-93 [12887976] J Biochem Mol Toxicol. 2003;17(5):249-54 [14595846] Ann Clin Res. 1973 Aug;5(4):214-9 [4203781] Dev Biol. 1976 Mar;49(1):200-19 [943344] Pharmacol Biochem Behav. 1976 Apr;4(4):385-91 [935210] Philos Trans R Soc Lond B Biol Sci. 1976 Aug 10;275(938):299-325 [8805] Teratology. 1978 Oct;18(2):285-8 [362594] Toxicol Ind Health. 1988 Dec;4(4):469-78 [3188044] J Pharmacol Exp Ther. 1995 Mar;272(3):1016-23 [7891311] Environ Res. 1998 May;77(2):73-8 [9600798] J Biol Chem. 1998 Nov 27;273(48):31962-70 [9822667] J Exp Zool. 1999 Jul 1;284(2):147-57 [10404644] Arch Toxicol. 2004 Oct;78(10):565-74 [15150681] Arch Toxicol. 2004 Oct;78(10):575-83 [15205888] Arch Environ Contam Toxicol. 2005 May;48(4):490-4 [15886897] Biometals. 2005 Oct;18(5):519-28 [16333752] Neurotoxicology. 2006 Jul;27(4):492-500 [16513172] Nat Rev Drug Discov. 2006 May;5(5):387-98 [16672925] Ann Clin Biochem. 2006 Jul;43(Pt 4):257-68 [16824275] Crit Rev Toxicol. 2006 Sep;36(8):609-62 [16973445] Toxicol Sci. 2006 Nov;94(1):129-38 [16896058] Brain Res. 2007 Feb 2;1131(1):1-10 [17182013] J Neurol Sci. 2007 Nov 15;262(1-2):131-44 [17681548] Toxicol In Vitro. 2007 Oct;21(7):1258-61 [17553660] PLoS One. 2007;2(12):e1259 [18060055] Toxicol Sci. 2008 Feb;101(2):215-25 [17989133] Genome Biol. 2007;8(6):R122 [17592649] Arch Environ Occup Health. 2007 Fall;62(3):121-8 [18400651] Toxicol Sci. 2008 Nov;106(1):5-28 [18566021] Environ Sci Technol. 2009 Apr 15;43(8):2983-8 [19475981] Neurochem Res. 2009 Sep;34(9):1677-84 [19347580] PLoS One. 2009;4(9):e7024 [19753116] Toxicol Appl Pharmacol. 2009 Oct 15;240(2):265-72 [19341752] Neurotoxicol Teratol. 2010 Jan-Feb;32(1):68-73 [19166924] Toxicol Appl Pharmacol. 2010 Jun 1;245(2):153-9 [20206647] Toxicol Sci. 2001 Feb;59(2):278-90 [11158721] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/etc.603 ER - TY - JOUR T1 - Controlled biodegradation of Self-assembling beta -hairpin Peptide hydrogels by proteolysis with matrix metalloproteinase-13 AN - 883036621; 15332208 AB - Controlled biodegradation specific to matrix metalloproteinase-13 was incorporated into the design of self-assembling beta -hairpin peptide hydrogels. Degrading Peptides (DP peptides) are a series of five peptides that have varying proteolytic susceptibilities toward MMP-13. These peptides undergo environmentally triggered folding and self-assembly under physiologically relevant conditions (150 mm NaCl, pH 7.6) to form self-supporting hydrogels. In the presence of enzyme, gels prepared from distinct peptides are degraded at rates that differ according to the primary sequence of the single peptide comprising the gel. Material degradation was monitored by oscillatory shear rheology over the course of 14 days, where overall degradation of the gels vary from 5% to 70%. Degradation products were analyzed by HPLC and identified by electrospray-ionization mass spectrometry. This data shows that proteolysis of the parent peptides constituting each gel occurs at the intended sequence location. DP hydrogels show specificity to MMP-13 and are only minimally cleaved by matrix metalloproteinase-3 (MMP-3), another common enzyme present during tissue injury. In vitro migration assays performed with SW1353 cells show that migration rates through each gel differs according to peptide sequence, which is consistent with the proteolysis studies using exogenous MMP-13. JF - Biomaterials AU - Giano, Michael C AU - Pochan, Darrin J AU - Schneider, Joel P AD - National Cancer Institute, Center for Cancer Research, Frederick, MD 21701, USA Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 6471 EP - 6477 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 32 IS - 27 SN - 0142-9612, 0142-9612 KW - Toxicology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - Biodegradation KW - Matrix metalloproteinase KW - Peptide KW - Self assembly KW - Hydrogel KW - Extracellular matrix KW - High-performance liquid chromatography KW - Proteolysis KW - Data processing KW - Stromelysin 1 KW - Injuries KW - Enzymes KW - Mass spectroscopy KW - Rheology KW - hydrogels KW - Self-assembly KW - Collagenase 3 KW - Cell migration KW - pH effects KW - Sodium chloride KW - Degradation products KW - Amino acid sequence KW - X 24360:Metals KW - A 01320:Microbial Degradation KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883036621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=Controlled+biodegradation+of+Self-assembling+beta+-hairpin+Peptide+hydrogels+by+proteolysis+with+matrix+metalloproteinase-13&rft.au=Giano%2C+Michael+C%3BPochan%2C+Darrin+J%3BSchneider%2C+Joel+P&rft.aulast=Giano&rft.aufirst=Michael&rft.date=2011-09-01&rft.volume=32&rft.issue=27&rft.spage=6471&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=01429612&rft_id=info:doi/10.1016%2Fj.biomaterials.2011.05.052 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Proteolysis; High-performance liquid chromatography; Biodegradation; Stromelysin 1; Data processing; Injuries; Enzymes; Mass spectroscopy; Rheology; hydrogels; Self-assembly; Collagenase 3; Cell migration; pH effects; Sodium chloride; Amino acid sequence; Degradation products DO - http://dx.doi.org/10.1016/j.biomaterials.2011.05.052 ER - TY - JOUR T1 - Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01. AN - 882089772; 21715490 AB - The structure of VRC01 in complex with the HIV-1 gp120 core reveals that this broadly neutralizing CD4 binding site (CD4bs) antibody partially mimics the interaction of the primary virus receptor, CD4, with gp120. Here, we extended the investigation of the VRC01-gp120 core interaction to the biologically relevant viral spike to better understand the mechanism of VRC01-mediated neutralization and to define viral elements associated with neutralization resistance. In contrast to the interaction of CD4 or the CD4bs monoclonal antibody (MAb) b12 with the HIV-1 envelope glycoprotein (Env), occlusion of the VRC01 epitope by quaternary constraints was not a major factor limiting neutralization. Mutagenesis studies indicated that VRC01 contacts within the gp120 loop D, the CD4 binding loop, and the V5 region were necessary for optimal VRC01 neutralization, as suggested by the crystal structure. In contrast to interactions with the soluble gp120 monomer, VRC01 interaction with the native viral spike did not occur in a CD4-like manner; VRC01 did not induce gp120 shedding from the Env spike or enhance gp41 membrane proximal external region (MPER)-directed antibody binding to the Env spike. Finally, VRC01 did not display significant reactivity with human antigens, boding well for potential in vivo applications. The data indicate that VRC01 interacts with gp120 in the context of the functional spike in a manner distinct from that of CD4. It achieves potent neutralization by precisely targeting the CD4bs without requiring alterations of Env spike configuration and by avoiding steric constraints imposed by the quaternary structure of the functional Env spike. JF - Journal of virology AU - Li, Yuxing AU - O'Dell, Sijy AU - Walker, Laura M AU - Wu, Xueling AU - Guenaga, Javier AU - Feng, Yu AU - Schmidt, Stephen D AU - McKee, Krisha AU - Louder, Mark K AU - Ledgerwood, Julie E AU - Graham, Barney S AU - Haynes, Barton F AU - Burton, Dennis R AU - Wyatt, Richard T AU - Mascola, John R AD - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 8954 EP - 8967 VL - 85 IS - 17 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Neutralizing KW - HIV Envelope Protein gp120 KW - Mutant Proteins KW - gp120 protein, Human immunodeficiency virus 1 KW - Index Medicus KW - Mutant Proteins -- genetics KW - Mutagenesis, Site-Directed KW - Models, Molecular KW - Mutant Proteins -- metabolism KW - Humans KW - Neutralization Tests KW - Enzyme-Linked Immunosorbent Assay KW - Protein Binding KW - Mutant Proteins -- immunology KW - Binding Sites KW - HIV-1 -- immunology KW - HIV Envelope Protein gp120 -- immunology KW - HIV Envelope Protein gp120 -- metabolism KW - HIV Envelope Protein gp120 -- genetics KW - Antibodies, Neutralizing -- immunology KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/882089772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Mechanism+of+neutralization+by+the+broadly+neutralizing+HIV-1+monoclonal+antibody+VRC01.&rft.au=Li%2C+Yuxing%3BO%27Dell%2C+Sijy%3BWalker%2C+Laura+M%3BWu%2C+Xueling%3BGuenaga%2C+Javier%3BFeng%2C+Yu%3BSchmidt%2C+Stephen+D%3BMcKee%2C+Krisha%3BLouder%2C+Mark+K%3BLedgerwood%2C+Julie+E%3BGraham%2C+Barney+S%3BHaynes%2C+Barton+F%3BBurton%2C+Dennis+R%3BWyatt%2C+Richard+T%3BMascola%2C+John+R&rft.aulast=Li&rft.aufirst=Yuxing&rft.date=2011-09-01&rft.volume=85&rft.issue=17&rft.spage=8954&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.00754-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-04 N1 - Date created - 2011-08-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2003 Mar 20;422(6929):307-12 [12646921] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4144-9 [12644702] Virology. 2003 Sep 1;313(2):387-400 [12954207] Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5036-41 [15051887] Nature. 1984 Dec 20-1985 Jan 2;312(5996):763-7 [6096719] Nature. 1984 Dec 20-1985 Jan 2;312(5996):767-8 [6083454] Science. 1986 Jan 24;231(4736):382-5 [3001934] J Virol. 1989 Jun;63(6):2674-9 [2786089] Proc Natl Acad Sci U S A. 1990 Jan;87(2):648-52 [2300552] J Virol. 1990 Nov;64(11):5674-7 [2214033] Science. 1990 Nov 23;250(4984):1139-42 [2251501] J Virol. 1991 Mar;65(3):1133-40 [1995942] Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2189-93 [2006155] J Acquir Immune Defic Syndr. 1991;4(9):923-4 [1895215] J Virol. 1993 Mar;67(3):1461-71 [8437224] J Virol. 1994 May;68(5):3015-26 [7512157] AIDS Res Hum Retroviruses. 1994 Apr;10(4):359-69 [7520721] Science. 1994 Nov 11;266(5187):1024-7 [7973652] Nat Struct Biol. 1995 Dec;2(12):1075-82 [8846219] J Virol. 1996 Feb;70(2):1100-8 [8551569] J Virol. 1996 Mar;70(3):1863-72 [8627711] Science. 1996 May 10;272(5263):872-7 [8629022] Nature. 1996 Jun 20;381(6584):661-6 [8649511] Nature. 1996 Jun 20;381(6584):667-73 [8649512] Cell. 1996 Jun 28;85(7):1135-48 [8674119] Cell. 1996 Jun 28;85(7):1149-58 [8674120] Science. 1996 Jun 28;272(5270):1955-8 [8658171] Nature. 1996 Nov 14;384(6605):179-83 [8906795] Nature. 1996 Nov 14;384(6605):184-7 [8906796] J Virol. 1997 May;71(5):3734-41 [9094648] Cell. 1997 Apr 18;89(2):263-73 [9108481] Nature. 1997 May 22;387(6631):426-30 [9163431] Nat Struct Biol. 1998 Apr;5(4):276-9 [9546217] J Virol. 2005 Jan;79(2):1252-61 [15613352] Virology. 2005 Feb 5;332(1):145-56 [15661147] Science. 2005 Jun 24;308(5730):1906-8 [15860590] J Virol. 2005 Aug;79(16):10108-25 [16051804] Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13372-7 [16174734] Annu Rev Immunol. 2006;24:739-69 [16551265] Hum Antibodies. 2005;14(3-4):59-67 [16720975] Nature. 2007 Feb 15;445(7129):732-7 [17301785] J Virol. 2007 Jun;81(12):6548-62 [17409160] J Virol. 2007 Jun;81(12):6187-96 [17409164] J Mol Biol. 2007 Sep 7;372(1):16-22 [17631311] Nat Med. 2007 Sep;13(9):1032-4 [17721546] J Virol. 2008 Jan;82(2):638-51 [17959660] PLoS Med. 2008 Jan 3;5(1):e9 [18177204] Nature. 2008 Sep 4;455(7209):109-13 [18668044] J Virol. 2008 Dec;82(23):11651-68 [18815292] J Virol. 2009 Jan;83(2):757-69 [18987148] J Virol. 2009 Jan;83(2):1045-59 [19004942] J Virol. 2009 Jul;83(14):7337-48 [19439467] Nat Med. 2009 Aug;15(8):866-70 [19525964] J Virol. 2009 Sep;83(17):8925-37 [19553335] J Virol. 2009 Nov;83(21):10892-907 [19692465] Science. 2009 Oct 9;326(5950):285-9 [19729618] J Virol. 2010 Feb;84(3):1631-6 [19923174] Annu Rev Immunol. 2010;28:413-44 [20192810] J Virol. 2010 Jun;84(11):5637-55 [20335257] Nat Struct Mol Biol. 2010 May;17(5):608-13 [20357769] Science. 2010 Aug 13;329(5993):811-7 [20616231] Science. 2010 Aug 13;329(5993):856-61 [20616233] J Virol. 2010 Oct;84(20):10510-21 [20686044] Virology. 2010 Dec 20;408(2):213-23 [20961591] AIDS Res Hum Retroviruses. 2011 Aug;27(8):877-87 [21158699] Science. 1998 Jun 19;280(5371):1884-8 [9632381] Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9026-31 [10922058] J Virol. 2001 Mar;75(5):2041-50 [11160708] J Virol. 2001 Nov;75(22):10892-905 [11602729] J Virol. 2001 Nov;75(22):10906-11 [11602730] J Virol. 2002 Jul;76(14):7293-305 [12072528] J Virol. 2002 Jul;76(14):7306-21 [12072529] J Virol. 2003 Jan;77(1):642-58 [12477867] Nature. 2002 Dec 12;420(6916):678-82 [12478295] J Virol. 2003 Feb;77(3):1666-71 [12525600] J Biol Chem. 2003 Feb 28;278(9):7573-9 [12486032] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.00754-11 ER - TY - JOUR T1 - Toxicity and carcinogenicity of androstenedione in F344/N rats and B6C3F1 mice. AN - 880716943; 21651954 AB - Androstenedione was marketed as a dietary supplement to increase muscle mass during training. Due to concern over long-term use, the NTP evaluated the subchronic and chronic toxicity and carcinogenicity of androstenedione in male and female F344/N rats and B6C3F1 mice. In subchronic studies, dose limiting effects were not observed. A chronic (2-year) exposure by gavage at 10, 20, or 50 mg/kg in rats and male mice, and 2, 10, or 50 mg/kg in female mice (50 mg/kg, maximum feasible dose) was conducted. Increased incidences of lung alveolar/bronchiolar adenoma and carcinoma occurred in the 20 mg/kg male rats and increases in mononuclear cell leukemia occurred in the 20 and 50 mg/kg female rats, which may have been related to androstenedione administration. In male and female mice, androstenedione was carcinogenic based upon a significant increase in hepatocellular tumors. A marginal increase in pancreatic islet cell adenomas in male (50 mg/kg) and female (2, 10, 50 mg/kg) mice was considered to be related to androstenedione administration. Interestingly, incidences of male rat Leydig cell adenomas and female rat mammary gland fibroadenomas decreased. In conclusion, androstenedione was determined to be carcinogenic in male and female mice, and may have been carcinogenic in rats. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Blystone, Chad R AU - Elmore, Susan A AU - Witt, Kristine L AU - Malarkey, David E AU - Foster, Paul M D AD - National Toxicology Program, National Institutes of Environmental Health Sciences, National Institute of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, United States. blystonecr@niehs.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 2116 EP - 2124 VL - 49 IS - 9 KW - Carcinogens KW - 0 KW - Androstenedione KW - 409J2J96VR KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Dose-Response Relationship, Drug KW - Carcinogenicity Tests KW - Mice KW - Male KW - Female KW - Androstenedione -- toxicity KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/880716943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Toxicity+and+carcinogenicity+of+androstenedione+in+F344%2FN+rats+and+B6C3F1+mice.&rft.au=Blystone%2C+Chad+R%3BElmore%2C+Susan+A%3BWitt%2C+Kristine+L%3BMalarkey%2C+David+E%3BFoster%2C+Paul+M+D&rft.aulast=Blystone&rft.aufirst=Chad&rft.date=2011-09-01&rft.volume=49&rft.issue=9&rft.spage=2116&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2011.05.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-07 N1 - Date created - 2011-08-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Transplantation. 1980 Aug;30(2):90-6 [7010713] Cancer. 1980 Sep 15;46(6):1401-4 [6251960] Carcinogenesis. 1983 Sep;4(9):1179-83 [6349845] Endocrinology. 1984 Jun;114(6):2100-6 [6539197] Biol Reprod. 1984 Sep;31(2):221-30 [6089920] Mutat Res. 1986 Jul;171(1):31-41 [3724781] Chir Pediatr. 1987;28(2):97-101 [3040281] Cancer Res. 1988 May 15;48(10):2788-92 [2965969] IARC Monogr Eval Carcinog Risks Hum Suppl. 1987;7:1-440 [3482203] Biometrics. 1988 Jun;44(2):417-31 [3390507] Breast Cancer Res Treat. 1989 Jan;13(1):61-9 [2495831] Fundam Appl Toxicol. 1989 May;12(4):731-7 [2744275] Proc Natl Acad Sci U S A. 1989 Oct;86(19):7505-9 [2798421] Anticancer Res. 1990 Mar-Apr;10(2A):337-42 [2189360] Acta Anat (Basel). 1991;140(2):97-103 [1867061] Environ Mol Mutagen. 1992;19 Suppl 21:2-141 [1541260] Cancer Res. 1992 May 15;52(10):2977-9 [1316232] Environ Mol Mutagen. 1993;21(2):160-79 [8444144] Carcinogenesis. 1995 Jun;16(6):1329-33 [7788850] Carcinogenesis. 1995 Dec;16(12):2893-8 [8603461] Toxicol Pathol. 1995 Sep-Oct;23(5):591-605 [8578102] Fundam Appl Toxicol. 1996 Jul;32(1):102-8 [8812243] Toxicol Pathol. 1998 May-Jun;26(3):428-41 [9608650] Crit Rev Toxicol. 1999 Mar;29(2):169-261 [10213111] JAMA. 1999 Jun 2;281(21):2020-8 [10359391] Curr Opin Pharmacol. 2004 Dec;4(6):614-20 [15525553] J Clin Endocrinol Metab. 2004 Dec;89(12):6235-8 [15579782] J Clin Endocrinol Metab. 2005 Feb;90(2):855-63 [15522925] Hum Reprod Update. 2005 Jul-Aug;11(4):411-23 [15817524] Gynakol Geburtshilfliche Rundsch. 2008;48(1):9-15 [18209494] Br J Pharmacol. 2008 Jun;154(3):502-21 [18500378] Apoptosis. 2008 Aug;13(8):959-71 [18543106] J Steroid Biochem Mol Biol. 2008 Jul;111(1-2):80-6 [18556192] Natl Toxicol Program Tech Rep Ser. 2010 Sep;(560):1, 7-31,33-171 passim [21037592] JAMA. 2000 Feb 9;283(6):779-82 [10683057] Environ Mol Mutagen. 2000;36(3):163-94 [11044899] Arch Intern Med. 2000 Nov 13;160(20):3093-104 [11074738] Fertil Steril. 2002 Apr;77 Suppl 4:S11-8 [12007897] J Clin Endocrinol Metab. 2002 Dec;87(12):5449-54 [12466335] Br J Sports Med. 2003 Jun;37(3):212-8 [12782545] FEMS Immunol Med Microbiol. 2003 Aug 18;38(1):13-22 [12900050] Horm Metab Res. 2004 Jan;36(1):62-6 [14983409] Rep Carcinog. 2002;10:116-9 [15323057] Am J Hematol. 2004 Nov;77(3):257-67 [15495253] Am J Anat. 1965 Nov;117(3):417-31 [4160088] J Anat. 1971 Jan;108(Pt 1):159-68 [4322581] Biometrics. 1971 Mar;27(1):103-17 [5547548] Biometrics. 1972 Jun;28(2):519-31 [5037867] Biometrics. 1977 Jun;33(2):386-9 [884197] Int Rev Cytol. 1977;50:333-96 [332658] Cell Tissue Res. 1978 Nov 20;194(2):269-77 [728964] Biol Reprod. 1979 Sep;21(2):455-63 [486667] Mutat Res. 1981 Mar;91(2):93-8 [7019696] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fct.2011.05.026 ER - TY - JOUR T1 - A pilot analytic study of a research-level, lower-cost human papillomavirus 16, 18, and 45 test. AN - 879103970; 21640138 AB - The analytic performance of a low-cost, research-stage DNA test for the most carcinogenic human papillomavirus (HPV) genotypes (HPV16, HPV18, and HPV45) in aggregate was evaluated among carcinogenic HPV-positive women, which might be used to decide who needs immediate colposcopy in low-resource settings ("triage test"). We found that HPV16/18/45 test agreed well with two DNA tests, a GP5+/6+ genotyping assay (Kappa = 0.77) and a quantitative PCR assay (at a cutpoint of 5000 viral copies) (Kappa = 0.87). DNA sequencing on a subset of 16 HPV16/18/45 positive and 16 HPV16/18/45 negative verified the analytic specificity of the research test. It is concluded that the HPV16/18/45 assay is a promising triage test with a minimum detection of approximately 5000 viral copies, the clinically relevant threshold. Published by Elsevier B.V. JF - Journal of virological methods AU - Yang, Hannah P AU - Walmer, David K AU - Merisier, Delson AU - Gage, Julia C AU - Bell, Laura AU - Rangwala, Sameera AU - Shrestha, Niwashin AU - Kobayashi, Lori AU - Eder, Paul S AU - Castle, Philip E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892-7234, USA. yanghan@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 112 EP - 114 VL - 176 IS - 1-2 KW - DNA, Viral KW - 0 KW - Index Medicus KW - DNA, Viral -- analysis KW - Humans KW - Cervix Uteri -- virology KW - Pilot Projects KW - Female KW - Colposcopy KW - Human papillomavirus 18 -- genetics KW - Human papillomavirus 16 -- isolation & purification KW - Human papillomavirus 18 -- classification KW - Polymerase Chain Reaction -- methods KW - Papillomavirus Infections -- virology KW - Human papillomavirus 18 -- isolation & purification KW - Cervical Intraepithelial Neoplasia -- virology KW - Human papillomavirus 16 -- genetics KW - Uterine Cervical Neoplasms -- virology KW - Human papillomavirus 16 -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879103970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virological+methods&rft.atitle=A+pilot+analytic+study+of+a+research-level%2C+lower-cost+human+papillomavirus+16%2C+18%2C+and+45+test.&rft.au=Yang%2C+Hannah+P%3BWalmer%2C+David+K%3BMerisier%2C+Delson%3BGage%2C+Julia+C%3BBell%2C+Laura%3BRangwala%2C+Sameera%3BShrestha%2C+Niwashin%3BKobayashi%2C+Lori%3BEder%2C+Paul+S%3BCastle%2C+Philip+E&rft.aulast=Yang&rft.aufirst=Hannah&rft.date=2011-09-01&rft.volume=176&rft.issue=1-2&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Journal+of+virological+methods&rft.issn=1879-0984&rft_id=info:doi/10.1016%2Fj.jviromet.2011.05.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-21 N1 - Date created - 2011-07-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Microbiol. 2002 Mar;40(3):902-7 [11880413] J Natl Cancer Inst. 2010 Oct 20;102(20):1557-67 [20884893] J Natl Cancer Inst. 2003 Mar 19;95(6):E2 [12644550] J Gen Virol. 1995 Apr;76 ( Pt 4):1057-62 [9049358] J Clin Microbiol. 1999 Mar;37(3):796-7 [9986857] Gynecol Oncol. 2005 Jul;98(1):84-91 [15894364] J Natl Cancer Inst. 2005 Jul 20;97(14):1072-9 [16030305] Lancet. 2005 Sep 17-23;366(9490):991-8 [16168781] Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1268-73 [16835322] Br J Cancer. 2007 May 7;96(9):1419-24 [17342094] Lancet Infect Dis. 2007 Jul;7(7):453-9 [17597569] Vaccine. 2008 Aug 19;26 Suppl 10:K29-41 [18847555] J Virol Methods. 2008 Dec;154(1-2):76-81 [18835300] Lancet Oncol. 2008 Oct;9(10):929-36 [18805733] J Clin Virol. 2009 Jul;45 Suppl 1:S3-S12 [19651367] J Natl Cancer Inst. 2010 Oct 20;102(20):1524-7 [20884892] N Engl J Med. 2003 Feb 6;348(6):518-27 [12571259] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jviromet.2011.05.024 ER - TY - JOUR T1 - Activation and regulation of purinergic P2X receptor channels. AN - 878596349; 21737531 AB - Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two transmembrane domains, and intracellular N and C termini. Functional P2XRs are organized as homomeric and heteromeric trimers. This review focuses on the binding sites involved in the activation (orthosteric) and regulation (allosteric) of P2XRs. The ectodomains contain three ATP binding sites, presumably located between neighboring subunits and formed by highly conserved residues. The detection and coordination of three ATP phosphate residues by positively charged amino acids are likely to play a dominant role in determining agonist potency, whereas an AsnPheArg motif may contribute to binding by coordinating the adenine ring. Nonconserved ectodomain histidines provide the binding sites for trace metals, divalent cations, and protons. The transmembrane domains account not only for the formation of the channel pore but also for the binding of ivermectin (a specific P2X4R allosteric regulator) and alcohols. The N- and C- domains provide the structures that determine the kinetics of receptor desensitization and/or pore dilation and are critical for the regulation of receptor functions by intracellular messengers, kinases, reactive oxygen species and mercury. The recent publication of the crystal structure of the zebrafish P2X4.1R in a closed state provides a major advance in the understanding of this family of receptor channels. We will discuss data obtained from numerous site-directed mutagenesis experiments accumulated during the last 15 years with reference to the crystal structure, allowing a structural interpretation of the molecular basis of orthosteric and allosteric ligand actions. JF - Pharmacological reviews AU - Coddou, Claudio AU - Yan, Zonghe AU - Obsil, Tomas AU - Huidobro-Toro, J Pablo AU - Stojilkovic, Stanko S AD - Section on Cellular Signaling, Program in Developmental Neuroscience, National Institute of Child Health and Human Developmant, National Institutes of Health, Bethesda, MD 20892-4510, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 641 EP - 683 VL - 63 IS - 3 KW - Metals KW - 0 KW - Nerve Tissue Proteins KW - Protein Isoforms KW - Purinergic P2X Receptor Agonists KW - Purinergic P2X Receptor Antagonists KW - Receptors, Purinergic P2X KW - Index Medicus KW - Protein Isoforms -- agonists KW - Animals KW - Metals -- pharmacology KW - Protein Isoforms -- chemistry KW - Protein Isoforms -- metabolism KW - Humans KW - Protein Isoforms -- antagonists & inhibitors KW - Protein Conformation KW - Metals -- toxicity KW - Binding Sites KW - Receptors, Purinergic P2X -- genetics KW - Receptors, Purinergic P2X -- metabolism KW - Receptors, Purinergic P2X -- chemistry KW - Nerve Tissue Proteins -- metabolism KW - Nerve Tissue Proteins -- genetics KW - Nerve Tissue Proteins -- chemistry KW - Purinergic P2X Receptor Antagonists -- pharmacology KW - Purinergic P2X Receptor Agonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878596349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacological+reviews&rft.atitle=Activation+and+regulation+of+purinergic+P2X+receptor+channels.&rft.au=Coddou%2C+Claudio%3BYan%2C+Zonghe%3BObsil%2C+Tomas%3BHuidobro-Toro%2C+J+Pablo%3BStojilkovic%2C+Stanko+S&rft.aulast=Coddou&rft.aufirst=Claudio&rft.date=2011-09-01&rft.volume=63&rft.issue=3&rft.spage=641&rft.isbn=&rft.btitle=&rft.title=Pharmacological+reviews&rft.issn=1521-0081&rft_id=info:doi/10.1124%2Fpr.110.003129 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-25 N1 - Date created - 2011-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 2002 Jul 26;295(4):849-53 [12127972] J Gen Physiol. 2002 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2004;240:31-304 [15548415] Toxicol Appl Pharmacol. 2005 Jan 15;202(2):121-31 [15629187] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/pr.110.003129 ER - TY - JOUR T1 - Effects of 5,6-benzoflavone, indole-3-carbinol (I3C) and diindolylmethane (DIM) on chemically-induced mammary carcinogenesis: is DIM a substitute for I3C? AN - 874900474; 21617870 AB - The abilities of 5,6-benzoflavone (5,6-BF, a synthetic flavonoid), indole-3-carbinol (I3C, a plant derived product) or diindolylmethane (DIM, a condensation product of I3C) to alter the induction of mammary cancers induced by the carcinogens 7,12-dimethylbenzanthracene (DMBA) or N-methyl-N-nitrosourea (MNU) were evaluated. Interestingly, the first two agents act as aryl hydrocarbon receptor (AhR) agonists, while DIM does not. The agents were initially examined for their ability to inhibit DMBA-induced mammary carcinogenesis. Agents were administered for 14 days starting 7 days prior to a single dose of the carcinogen. Evaluated over an extensive range of doses (165, 550 and 1650 ppm in the diet), 5,6-BF caused a dose-dependent decrease of mammary cancers. In addition, 5,6-BF at doses of 1650 and 165 ppm in the diet blocked the induction of DMBA-induced DNA adducts in the mammary gland by approximately 85% and 45%, respectively. In contrast, DIM (180 or 20 mg/kg BW/day) failed to block induction of DMBA tumors. The effect of these agents on the promotion/progression phase of carcinogenesis using the MNU mammary cancer model was also determined. 5,6-BF (1650 or 165 ppm in the diet), I3C (180 or 60 mg/kg BW/day administered by gavage), or DIM (180 or 60 mg/kg BW/day by gavage) were initiated 5 days after the administration of MNU, and continually thereafter. 5,6-BF decreased MNU- induced mammary tumor multiplicity by 40-60%. I3C reduced tumor multiplicity at the high dose, while DIM at either dose had minimal effects on tumor multiplicity. Thus, 5,6-BF and I3C were highly effective against initiation of DMBA-induced mammary carcinogenesis, and were also effective against MNU-induced tumors during the promotion/progression phase of carcinogenesis. In contrast, DIM had minimal effects in either model; arguing that administration of DIM is not analogous to administration of I3C. JF - Oncology reports AU - Lubet, Ronald A AU - Heckman, Brandy M AU - De Flora, Silvio L AU - Steele, Vernon E AU - Crowell, James A AU - Juliana, M Margaret AU - Grubbs, Clinton J AD - Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Suite 2110, NIH, NCI, 9000 Rockville Pike, Bethesda, MD 20892, USA. lubetr@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 731 EP - 736 VL - 26 IS - 3 KW - Anticarcinogenic Agents KW - 0 KW - Indoles KW - diindolylmethane KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - beta-Naphthoflavone KW - 6051-87-2 KW - Methylnitrosourea KW - 684-93-5 KW - indole-3-carbinol KW - C11E72455F KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Cyp1b1 protein, rat KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP1B1 KW - Index Medicus KW - Animals KW - Cytochrome P-450 CYP1A1 -- genetics KW - Mammary Glands, Animal -- drug effects KW - Tumor Burden KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Transcription, Genetic KW - Rats KW - Rats, Sprague-Dawley KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Epithelial Cells -- drug effects KW - Epithelial Cells -- pathology KW - Mammary Glands, Animal -- pathology KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Female KW - Mammary Neoplasms, Experimental -- chemically induced KW - Anticarcinogenic Agents -- pharmacology KW - beta-Naphthoflavone -- pharmacology KW - Indoles -- pharmacology KW - Mammary Neoplasms, Experimental -- prevention & control KW - Mammary Neoplasms, Experimental -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874900474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+reports&rft.atitle=Effects+of+5%2C6-benzoflavone%2C+indole-3-carbinol+%28I3C%29+and+diindolylmethane+%28DIM%29+on+chemically-induced+mammary+carcinogenesis%3A+is+DIM+a+substitute+for+I3C%3F&rft.au=Lubet%2C+Ronald+A%3BHeckman%2C+Brandy+M%3BDe+Flora%2C+Silvio+L%3BSteele%2C+Vernon+E%3BCrowell%2C+James+A%3BJuliana%2C+M+Margaret%3BGrubbs%2C+Clinton+J&rft.aulast=Lubet&rft.aufirst=Ronald&rft.date=2011-09-01&rft.volume=26&rft.issue=3&rft.spage=731&rft.isbn=&rft.btitle=&rft.title=Oncology+reports&rft.issn=1791-2431&rft_id=info:doi/10.3892%2For.2011.1316 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-24 N1 - Date created - 2011-07-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3892/or.2011.1316 ER - TY - JOUR T1 - HDAC inhibitor vorinostat enhances the antitumor effect of gefitinib in squamous cell carcinoma of head and neck by modulating ErbB receptor expression and reverting EMT. AN - 871389260; 21660961 AB - Potentiation of epidermal growth factor receptor (EGFR) inhibitors is required in squamous cell carcinoma of head and neck (SCCHN) to improve their therapeutic index. We demonstrated that the histone deacetylase inhibitor vorinostat in combination with the EGFR tyrosine kinase inhibitor gefitinib induced synergistic inhibition of proliferation, migration, and invasion as well as induction of apoptosis in SCCHN cells, including cells resistant to gefitinib. We provided evidence suggesting that differential modulation of ErbB receptors together with reversion of epithelial-to-mesenchymal transition (EMT) by vorinostat represent mechanistic bases for the observed synergism. We demonstrated in epithelial CAL27 cells expressing EGFR, ErbB2, and ErbB3 that vorinostat downregulated the expression and signaling of all three receptors. In gefitinib-resistant KB and Hep-2 cells, both of which had undergone EMT and expressed very low levels of ErbB3, vorinostat reverted the mesenchymal phenotype by inducing both E-cadherin and ErbB3 and downregulating vimentin as well as EGFR and ErbB2. Both transcriptional and post-translational mechanisms were involved in the modulation of ErbB receptors by vorinostat. Attenuation of all ErbB transcripts in CAL27 cells as well as induction of ErbB3 transcript in Hep-2 and KB cells was seen upon vorinostat treatment. We showed that vorinostat induced ubiquitination of EGFR and ErbB2 and targeted them predominantly to lysosome-degradation in all cell lines, while the induction of ErbB3-ubiquitination in CAL27 cells led to proteasomes-degradation. Overall, this study suggests that the vorinostat/gefitinib combination represents a promising therapeutic strategy that warrants further clinical evaluation in SCCHN, including tumors intrinsically resistant to EGFR-inhibitors. Copyright © 2010 Wiley-Liss, Inc. JF - Journal of cellular physiology AU - Bruzzese, Francesca AU - Leone, Alessandra AU - Rocco, Monia AU - Carbone, Carmine AU - Piro, Geny AU - Caraglia, Michele AU - Di Gennaro, Elena AU - Budillon, Alfredo AD - Experimental Pharmacology Unit, Department of Research, National Cancer Institute Fondazione G Pascale, Naples, Italy. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 2378 EP - 2390 VL - 226 IS - 9 KW - Biomarkers, Tumor KW - 0 KW - Histone Deacetylase Inhibitors KW - Hydroxamic Acids KW - Quinazolines KW - RNA, Messenger KW - vorinostat KW - 58IFB293JI KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Receptor, ErbB-2 KW - Receptor, ErbB-3 KW - gefitinib KW - S65743JHBS KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Drug Screening Assays, Antitumor KW - Receptor, Epidermal Growth Factor -- metabolism KW - Histone Deacetylase Inhibitors -- pharmacology KW - Humans KW - Cell Line, Tumor KW - RNA, Messenger -- genetics KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Biomarkers, Tumor -- metabolism KW - Receptor, Epidermal Growth Factor -- genetics KW - RNA, Messenger -- metabolism KW - Ubiquitination -- drug effects KW - Cell Movement -- drug effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Drug Synergism KW - Receptor, ErbB-2 -- genetics KW - Receptor, ErbB-3 -- metabolism KW - Receptor, ErbB-2 -- metabolism KW - Carcinoma, Squamous Cell -- pathology KW - Receptor, ErbB-3 -- genetics KW - Carcinoma, Squamous Cell -- genetics KW - Head and Neck Neoplasms -- pathology KW - Epithelial-Mesenchymal Transition -- drug effects KW - Head and Neck Neoplasms -- genetics KW - Hydroxamic Acids -- pharmacology KW - Head and Neck Neoplasms -- drug therapy KW - Carcinoma, Squamous Cell -- drug therapy KW - Quinazolines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/871389260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+physiology&rft.atitle=HDAC+inhibitor+vorinostat+enhances+the+antitumor+effect+of+gefitinib+in+squamous+cell+carcinoma+of+head+and+neck+by+modulating+ErbB+receptor+expression+and+reverting+EMT.&rft.au=Bruzzese%2C+Francesca%3BLeone%2C+Alessandra%3BRocco%2C+Monia%3BCarbone%2C+Carmine%3BPiro%2C+Geny%3BCaraglia%2C+Michele%3BDi+Gennaro%2C+Elena%3BBudillon%2C+Alfredo&rft.aulast=Bruzzese&rft.aufirst=Francesca&rft.date=2011-09-01&rft.volume=226&rft.issue=9&rft.spage=2378&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+physiology&rft.issn=1097-4652&rft_id=info:doi/10.1002%2Fjcp.22574 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-17 N1 - Date created - 2011-06-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jcp.22574 ER - TY - JOUR T1 - Hospitalizations for Alcohol and Drug Overdoses in Young Adults Ages 18-24 in the United States, 1999-2008: Results From the Nationwide Inpatient Sample AN - 1823506460; 201121061 AB - Objective: Recent reports indicate an increase in rates of hospitalizations for drug overdoses in the United States. The role of alcohol in hospitalizations for drug overdoses remains unclear. Excessive consumption of alcohol and drugs is prevalent in young adults ages 18-24. The present study explores rates and costs of inpatient hospital stays for alcohol overdoses, drug overdoses, and their co-occurrence in young adults ages 18-24 and changes in these rates between 1999 and 2008. Method: Data from the Nationwide Inpatient Sample were used to estimate numbers, rates, and costs of inpatient hospital stays stemming from alcohol overdoses (and their subcategories, alcohol poisonings and excessive consumption of alcohol), drug overdoses (and their subcategories, drug poisonings and nondependent abuse of drugs), and their co-occurrence in 18- to 24-year-olds. Results: Hospitalization rates for alcohol overdoses alone increased 25% from 1999 to 2008, reaching 29,412 cases in 2008 at a cost of $266 million. Hospitalization rates for drug overdoses alone increased 55%, totaling 113,907 cases in 2008 at a cost of $737 million. Hospitalization rates for combined alcohol and drug overdoses increased 76%, with 29,202 cases in 2008 at a cost of $198 million. Conclusions: Rates of hospitalizations for alcohol overdoses, drug overdoses, and their combination all increased from 1999 to 2008 among 18- to 24-year-olds. The cost of such hospitalizations now exceeds $1.2 billion annually. The steepest increase occurred among cases of combined alcohol and drug overdoses. Stronger efforts are needed to educate medical practitioners and the public about the risk of overdoses, particularly when alcohol is combined with other drugs. Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - White, Aaron M AU - Hingson, Ralph W AU - Pan, I-Jen AU - Yi, Hsiao-Ye AD - Division of Epidemiology and Prevention Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, MSC 9304, Room 2074, Bethesda, Maryland 20892-9304 whitea4@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 774 EP - 786 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 72 IS - 5 SN - 1937-1888, 1937-1888 KW - Alcohol consumption KW - Hospitalization KW - Poisoning KW - Young adults KW - Overdoses KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1823506460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=Hospitalizations+for+Alcohol+and+Drug+Overdoses+in+Young+Adults+Ages+18-24+in+the+United+States%2C+1999-2008%3A+Results+From+the+Nationwide+Inpatient+Sample&rft.au=White%2C+Aaron+M%3BHingson%2C+Ralph+W%3BPan%2C+I-Jen%3BYi%2C+Hsiao-Ye&rft.aulast=White&rft.aufirst=Aaron&rft.date=2011-09-01&rft.volume=72&rft.issue=5&rft.spage=774&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Overdoses; Hospitalization; Young adults; Alcohol consumption; Hospitals; Poisoning ER - TY - JOUR T1 - Q sub( gamma -H2AX), an analysis method for partial-body radiation exposure using gamma -H2AX in non-human primate lymphocytes AN - 1744672939; 15744657 AB - We previously used the gamma -H2AX assay as a biodosimeter for total-body irradiation (TBI) exposure ( gamma -rays) in a rhesus macaque (Macaca mulatta) model. Utilizing peripheral blood lymphocytes and plucked hairs, we obtained statistically significant gamma -H2AX responses days after total-body exposure to 1-8.5 Gy ( super(60)Co gamma -rays at 55 cGy min super(-1)). Here, we introduce a partial-body exposure analysis method, Q sub( gamma -H2AX), which is based on the number of gamma -H2AX foci per damaged cells as evident by having one or more gamma -H2AX foci per cell. Results from the rhesus monkey - TBI study were used to establish Q sub( gamma -H2AX) dose-response calibration curves to assess acute partial-body exposures. gamma -H2AX foci were detected in plucked hairs for several days after in vivo irradiation demonstrating this assay's utility for dose assessment in various body regions. The quantitation of gamma -H2AX may provide a robust biodosimeter for analyzing partial-body exposures to ionizing radiation in humans. JF - Radiation Measurements AU - Redon, Christophe E AU - Nakamura, Asako J AU - Gouliaeva, Ksenia AU - Rahman, Arifur AU - Blakely, William F AU - Bonner, William M Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 877 EP - 881 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 46 IS - 9 SN - 1350-4487, 1350-4487 KW - Solid State and Superconductivity Abstracts (SO); Advanced Polymers Abstracts (EP); Environmental Engineering Abstracts (EN); Composites Industry Abstracts (ED); Engineered Materials Abstracts, Ceramics (EC) KW - Biological dosimetry KW - gamma -H2AX KW - Q gamma -H2AX KW - F gamma -H2AX KW - Rhesus macaque (Macaca mulatta) KW - Lymphocytes KW - 60Co gamma -rays KW - Ionizing radiation KW - Partial-body exposure KW - Assaying KW - Monkeys KW - Assessments KW - Surgical implants KW - Irradiation KW - Hair UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1744672939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Measurements&rft.atitle=Q+sub%28+gamma+-H2AX%29%2C+an+analysis+method+for+partial-body+radiation+exposure+using+gamma+-H2AX+in+non-human+primate+lymphocytes&rft.au=Redon%2C+Christophe+E%3BNakamura%2C+Asako+J%3BGouliaeva%2C+Ksenia%3BRahman%2C+Arifur%3BBlakely%2C+William+F%3BBonner%2C+William+M&rft.aulast=Redon&rft.aufirst=Christophe&rft.date=2011-09-01&rft.volume=46&rft.issue=9&rft.spage=877&rft.isbn=&rft.btitle=&rft.title=Radiation+Measurements&rft.issn=13504487&rft_id=info:doi/10.1016%2Fj.radmeas.2011.02.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1016/j.radmeas.2011.02.017 ER - TY - JOUR T1 - Lung imaging in asthmatic patients: The picture is clearer AN - 1514896743; 21636118 AB - Imaging of the lungs in patients with asthma has evolved dramatically over the last decade with sophisticated techniques, such as computed tomography, magnetic resonance imaging, positron emission tomography, and single photon emission computed tomography. New insights into current and future modalities for imaging in asthmatic patients and their application are discussed to potentially shed a clearer picture of the underlying pathophysiology of asthma, especially severe asthma, and the proposed clinical utility of imaging in patients with this common disease. JF - Journal of Allergy and Clinical Immunology AU - Castro, Mario AU - Fain, Sean B AU - Hoffman, Eric A AU - Gierada, David S AU - Erzurum, Serpil C AU - Wenzel, Sally Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 467 EP - 78 CY - St. Louis PB - Elsevier Science Ltd. VL - 128 IS - 3 SN - 00916749 KW - Abstracting And Indexing Services KW - Asthma KW - Studies KW - Medical imaging KW - Anatomy & physiology KW - Ventilation KW - Lungs KW - Algorithms KW - Trees KW - Dimensional analysis KW - Magnetic Resonance Imaging KW - Tomography, Emission-Computed, Single-Photon KW - Positron-Emission Tomography KW - Humans KW - Tomography, X-Ray Computed KW - Asthma -- physiopathology KW - Asthma -- radiography KW - Lung -- radiography KW - Diagnostic Imaging -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1514896743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=Lung+imaging+in+asthmatic+patients%3A+The+picture+is+clearer&rft.au=Castro%2C+Mario%3BFain%2C+Sean+B%3BHoffman%2C+Eric+A%3BGierada%2C+David+S%3BErzurum%2C+Serpil+C%3BWenzel%2C+Sally&rft.aulast=Castro&rft.aufirst=Mario&rft.date=2011-09-01&rft.volume=128&rft.issue=3&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/10.1016%2Fj.jaci.2011.04.051 LA - English DB - ProQuest Central N1 - Copyright - Copyright Elsevier Limited Sep 2011 N1 - Last updated - 2014-09-26 DO - http://dx.doi.org/10.1016/j.jaci.2011.04.051 ER - TY - JOUR T1 - Two-stage sector sampling for estimating small woodlot attributes AN - 1032895837; 16957564 AB - A two-stage sampling strategy is proposed to assess small woodlots outside the forests scattered on extensive territories. The first stage is performed to select a sample of small woodlots using fixed-size sampling schemes, and the second stage is performed to sample trees within woodlots selected at first stage. Usually, fixed- or variable-area plots are adopted to sample trees. However, the use of plot sampling in small patches such as woodlots is likely to induce a relevant amount of bias owing to edge effects. In this framework, sector sampling proves to be particularly effective. The present paper investigates the statistical properties of two-stage sampling strategies for estimating forest attributes of woodlot populations when sector sampling is adopted at the second stage. A two-stage estimator of population totals is derived together with a conservative estimator of its sampling variance. By means of a simulation study, the performance of the proposed estimator is checked and compared with that achieved using traditional plot sampling with edge corrections. Simulation results prove the adequacy of sector sampling and provide some guidelines for the effective planning of the strategy. In some countries, the proposed strategy can be performed with few modifications within the framework of large-scale forest inventories.Original Abstract: Une strategie d'echantillonnage en deux etapes est proposee pour evaluer les petits boises situes a l'ecart des forets et disperses sur de vastes territoires. La premiere etape sert a selectionner un echantillon de petits boises en utilisant des plans d'echantillonnage a surface fixe tandis que la deuxieme etape sert a echantillonner les arbres dans les boises selectionnes lors de la premiere etape. Habituellement, des placettes a surface fixe ou variable sont utilisees pour echantillonner les arbres. Cependant, l'utilisation de placettes dans de petits boises est susceptible d'induire un biais appreciable du a l'effet de bordure. Dans ce cas, l'echantillonnage par secteur se revele particulierement efficace. Le present article etudie les proprietes statistiques des strategies d'echantillonnage en deux etapes pour estimer les attributs forestiers de populations de boises lorsque l'echantillonnage par secteur est utilise lors de la deuxieme etape. Un estimateur en deux etapes des totaux de population est derive avec un estimateur conservateur de sa variance d'echantillonnage. La performance de l'estimateur propose est verifiee et comparee par simulation avec celle obtenue par l'echantillonnage traditionnel accompagne d'une correction pour tenir compte de l'effet de bordure. Les resultats de la simulation demontrent que l'echantillonnage par secteur est adequat et fournissent des lignes directrices pour la planification efficace de la strategie d'echantillonnage. Dans certains pays, la strategie proposee peut etre realisee avec peu de modifications dans le cadre de l'inventaire forestier a grande echelle. JF - Canadian Journal of Forest Research/Revue Canadienne de Recherche Forestiere AU - Corona, Piermaria AU - Fattorini, Lorenzo AU - Franceschi, Sara AD - Dipartimento per l'Innovazione nei Sistemi Biologici, Agroalimentari e Forestali (DIBAF), Universita della Tuscia, via San Camillo de Lellis, 01100 Viterbo, Italy., fattorini@unisi.it Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1819 EP - 1826 PB - NRC Research Press VL - 41 IS - 9 SN - 0045-5067, 0045-5067 KW - Environment Abstracts; Sustainability Science Abstracts; Ecology Abstracts KW - Inventories KW - Statistics KW - Trees KW - Guidelines KW - Simulation KW - Forests KW - Territory KW - Edge effect KW - Sampling KW - ENA 13:Population Planning & Control KW - M3 1010:Issues in Sustainable Development KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1032895837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Canadian+Journal+of+Forest+Research%2FRevue+Canadienne+de+Recherche+Forestiere&rft.atitle=Two-stage+sector+sampling+for+estimating+small+woodlot+attributes&rft.au=Corona%2C+Piermaria%3BFattorini%2C+Lorenzo%3BFranceschi%2C+Sara&rft.aulast=Corona&rft.aufirst=Piermaria&rft.date=2011-09-01&rft.volume=41&rft.issue=9&rft.spage=1819&rft.isbn=&rft.btitle=&rft.title=Canadian+Journal+of+Forest+Research%2FRevue+Canadienne+de+Recherche+Forestiere&rft.issn=00455067&rft_id=info:doi/10.1139%2Fx11-101 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Number of references - 19 N1 - Last updated - 2015-05-27 N1 - SubjectsTermNotLitGenreText - Inventories; Statistics; Trees; Forests; Territory; Sampling; Edge effect; Guidelines; Simulation DO - http://dx.doi.org/10.1139/x11-101 ER - TY - JOUR T1 - Optimal estimating functions in incomplete data and length biased sampling data problems AN - 1031278449; 4317939 AB - It is well known that the score function is the optimal estimating function among all regular unbiased estimating functions (Godambe, 1960). In the presence of incomplete data such as missing data or length biased sampling data, Horvitz and Thompson's (1952) method is an effective way of eliminating the possible bias induced by using complete data only. In this article, we show that the inverse weighted Horvitz and Thompson score estimating function is not optimal in the presence of incomplete data. By using Godambe's estimating function theory, we can identify the optimal estimating function in this situation. In the case of the accelerated failure time model with length bias sampling data, the optimal estimating function can produce an unbiased estimator for the slope parameter even when the underlying density function is misspecified. Simulation studies show that the estimate derived from the optimal estimating function can be substantially better than the estimate derived from the inverse weighted score estimating function. JF - Canadian journal of statistics AU - Zhang, Biao AU - Qin, Jing AD - National Institute of Allergy and Infectious Diseases, USA Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 510 EP - 518 VL - 39 IS - 3 SN - 0319-5724, 0319-5724 KW - Economics KW - Godambe estimating function KW - Score functions KW - Simulation KW - Estimation KW - Sampling KW - Data analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1031278449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Canadian+journal+of+statistics&rft.atitle=Optimal+estimating+functions+in+incomplete+data+and+length+biased+sampling+data+problems&rft.au=Zhang%2C+Biao%3BQin%2C+Jing&rft.aulast=Zhang&rft.aufirst=Biao&rft.date=2011-09-01&rft.volume=39&rft.issue=3&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=Canadian+journal+of+statistics&rft.issn=03195724&rft_id=info:doi/10.1002%2Fcjs LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11255 12228 10919; 4403 7854; 11670; 3279 971 3286 DO - http://dx.doi.org/10.1002/cjs ER - TY - JOUR T1 - An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies AN - 1020847950; 15397675 AB - Background: Greater tobacco smoking and alcohol consumption and lower body mass index (BMI) increase odds ratios (OR) for oral cavity, oropharyngeal, hypopharyngeal, and laryngeal cancers; however, there are no comprehensive sex-specific comparisons of ORs for these factors. Methods: We analyzed 2,441 oral cavity (925 women and 1,516 men), 2,297 oropharynx (564 women and 1,733 men), 508 hypopharynx (96 women and 412 men), and 1,740 larynx (237 women and 1,503 men) cases from the INHANCE consortium of 15 head and neck cancer case-control studies. Controls numbered from 7,604 to 13,829 subjects, depending on analysis. Analyses fitted linear-exponential excess ORs models. Results: ORs were increased in underweight (<18.5 BMI) relative to normal weight (18.5-24.9) and reduced in overweight and obese categories ( greater than or equal to 25 BMI) for all sites and were homogeneous by sex. ORs by smoking and drinking in women compared with men were significantly greater for oropharyngeal cancer (p < 0.01 for both factors), suggestive for hypopharyngeal cancer (p = 0.05 and p = 0.06, respectively), but homogeneous for oral cavity (p = 0.56 and p = 0.64) and laryngeal (p = 0.18 and p = 0.72) cancers. Conclusions: The extent that OR modifications of smoking and drinking by sex for oropharyngeal and, possibly, hypopharyngeal cancers represent true associations, or derive from unmeasured confounders or unobserved sex-related disease subtypes (e.g., human papillomavirus-positive oropharyngeal cancer) remains to be clarified. JF - Cancer Causes & Control AU - Lubin, Jay H AU - Muscat, Joshua AU - Gaudet, Mia M AU - Olshan, Andrew F AU - Curado, Maria Paula AU - Dal Maso, Luigino AU - Wunsch-Filho, Victor AU - Sturgis, Erich M AU - Szeszenia-Dabrowska, Neonilia AU - Castellsague, Xavier AU - Zhang, Zuo-Feng AU - Smith, Elaine AU - Fernandez, Leticia AU - Matos, Elena AU - Franceschi, Silvia AU - Fabianova, Eleonora AU - Rudnai, Peter AU - Purdue, Mark P AU - Mates, Dana AU - Wei, Qingyi AU - Herrero, Rolando AU - Kelsey, Karl AU - Morgenstern, Hal AU - Shangina, Oxana AU - Koifman, Sergio AU - Lissowska, Jolanta AU - Levi, Fabio AU - Daudt, Alexander W AU - Neto, Jose Eluf AU - Chen, Chu AU - Lazarus, Philip AU - Winn, Deborah M AU - Schwartz, Stephen M AU - Boffetta, Paolo AU - Brennan, Paul AU - Menezes, Ana AU - Vecchia, Carlo La AU - McClean, Michael AU - Talamini, Renato AU - Rajkumar, Thangarajan AU - Hayes, Richard B AU - Hashibe, Mia AD - Occupational Health Department, Institute of Public Health, Bucharest, Romania, lubinj@mail.nih.gov lubinj@mail.nih.gov lubinj@mail.nih.gov lubinj@mail.nih.gov lubinj@mail.nih.gov lubinj@mail.nih.gov lubinj@mail.nih.gov lubinj@mail.nih.gov lubinj@mail.nih.gov lubinj@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1217 EP - 1231 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 22 IS - 9 SN - 0957-5243, 0957-5243 KW - Physical Education Index KW - Smoking KW - Alcohol KW - Obesity KW - Men KW - Body mass KW - Analysis KW - Women KW - Tobacco KW - Cancer KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020847950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=An+examination+of+male+and+female+odds+ratios+by+BMI%2C+cigarette+smoking%2C+and+alcohol+consumption+for+cancers+of+the+oral+cavity%2C+pharynx%2C+and+larynx+in+pooled+data+from+15+case-control+studies&rft.au=Lubin%2C+Jay+H%3BMuscat%2C+Joshua%3BGaudet%2C+Mia+M%3BOlshan%2C+Andrew+F%3BCurado%2C+Maria+Paula%3BDal+Maso%2C+Luigino%3BWunsch-Filho%2C+Victor%3BSturgis%2C+Erich+M%3BSzeszenia-Dabrowska%2C+Neonilia%3BCastellsague%2C+Xavier%3BZhang%2C+Zuo-Feng%3BSmith%2C+Elaine%3BFernandez%2C+Leticia%3BMatos%2C+Elena%3BFranceschi%2C+Silvia%3BFabianova%2C+Eleonora%3BRudnai%2C+Peter%3BPurdue%2C+Mark+P%3BMates%2C+Dana%3BWei%2C+Qingyi%3BHerrero%2C+Rolando%3BKelsey%2C+Karl%3BMorgenstern%2C+Hal%3BShangina%2C+Oxana%3BKoifman%2C+Sergio%3BLissowska%2C+Jolanta%3BLevi%2C+Fabio%3BDaudt%2C+Alexander+W%3BNeto%2C+Jose+Eluf%3BChen%2C+Chu%3BLazarus%2C+Philip%3BWinn%2C+Deborah+M%3BSchwartz%2C+Stephen+M%3BBoffetta%2C+Paolo%3BBrennan%2C+Paul%3BMenezes%2C+Ana%3BVecchia%2C+Carlo+La%3BMcClean%2C+Michael%3BTalamini%2C+Renato%3BRajkumar%2C+Thangarajan%3BHayes%2C+Richard+B%3BHashibe%2C+Mia&rft.aulast=Lubin&rft.aufirst=Jay&rft.date=2011-09-01&rft.volume=22&rft.issue=9&rft.spage=1217&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9792-x LA - English DB - Physical Education Index N1 - Date revised - 2012-06-01 N1 - Last updated - 2013-08-23 N1 - SubjectsTermNotLitGenreText - Obesity; Alcohol; Smoking; Men; Analysis; Body mass; Women; Tobacco; Cancer DO - http://dx.doi.org/10.1007/s10552-011-9792-x ER - TY - JOUR T1 - Reduced Fear Memory and Anxiety-like Behavior in Mice Lacking Formylpeptide Receptor 1 AN - 1018375935; 201210644 AB - N-formylpeptide receptor 1 (FPR1) is a G protein-coupled receptor that mediates pro-inflammatory chemotactic responses by phagocytic leukocytes to N-formylpeptides produced by bacteria or mitochondria. Mice lacking Fpr1 (Fpr1 -/- mice) have increased susceptibility to challenge with certain bacteria. FPR1 is also a receptor for annexin-1, which mediates the anti-inflammatory effects of glucocorticoids as well as negative feedback by glucocorticoids of the hypothalamic-pituitary-adrenocortical axis. However, homeostatic functions of FPR1 in the neuroendocrine system have not previously been defined. Here we show that in systematic behavioral testing Fpr1 -/- mice exhibited increased exploratory activity, reduced anxiety-like behavior, and impaired fear memory, but normal spatial memory and learning capacity. Consistent with this, the homeostatic serum level of corticosterone in Fpr1 -/- mice was significantly lower compared with wild-type mice. The data implicate Fpr1 in modulation of anxiety-like behavior and fear memory by regulating glucocorticoid production. Adapted from the source document. JF - Behavior Genetics AU - Gao, Ji-Liang AU - Schneider, Erich H AU - Dimitrov, Eugene L AU - Haun, Forrest AU - Pham, Therese M AU - Mohammed, Abdul H AU - Usdin, Ted B AU - Murphy, Philip M AD - Molecular Signalling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N107, NIH, Bethesda, MD, 20892, USA jgao@niaid.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 724 EP - 733 PB - Springer Science+Business Media, Inc, New York, NY VL - 41 IS - 5 SN - 0001-8244, 0001-8244 KW - Bacteria KW - Animals KW - Learning KW - Memory KW - Negative feedback KW - Fear KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018375935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavior+Genetics&rft.atitle=Reduced+Fear+Memory+and+Anxiety-like+Behavior+in+Mice+Lacking+Formylpeptide+Receptor+1&rft.au=Gao%2C+Ji-Liang%3BSchneider%2C+Erich+H%3BDimitrov%2C+Eugene+L%3BHaun%2C+Forrest%3BPham%2C+Therese+M%3BMohammed%2C+Abdul+H%3BUsdin%2C+Ted+B%3BMurphy%2C+Philip+M&rft.aulast=Gao&rft.aufirst=Ji-Liang&rft.date=2011-09-01&rft.volume=41&rft.issue=5&rft.spage=724&rft.isbn=&rft.btitle=&rft.title=Behavior+Genetics&rft.issn=00018244&rft_id=info:doi/10.1007%2Fs10519-011-9467-0 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BHGHAT N1 - SubjectsTermNotLitGenreText - Animals; Memory; Fear; Bacteria; Negative feedback; Learning DO - http://dx.doi.org/10.1007/s10519-011-9467-0 ER - TY - JOUR T1 - Cancer nanotechnology research in the United States and China: cooperation to promote innovation AN - 1017978439; 16719795 AB - The application of nanotechnology to cancer research is a promising area for US-China cooperation. Cancer is a major public health burden in both countries, and progress in cancer nanotechnology research is increasing in several fields, including imaging, biomarker detection, and targeted drug delivery. The United States and China are international leaders in nanotechnology research, and have both launched national programs to support nanotechnology efforts in the recent past. The accelerating trend of co-authorship among US and Chinese nanotechnology researchers demonstrates that individual scientists already recognize the potential for cooperation, providing a strong platform for creating additional partnerships in pre-competitive research areas. Mechanisms that could help to enhance US-China cancer nanotechnology partnerships include: developing new programs for bi-directional training and exchange; convening workshops focused on specific scientific topics of high priority to both countries; and joint support of collaborative research projects by US and Chinese funders. In addition to the accelerating scientific progress, expanded cooperation will stimulate important dialog on regulatory, policy, and technical issues needed to lay the groundwork for US and Chinese scientists to move greater numbers of cancer nanotechnology applications into the clinic. WIREs Nanomed Nanobiotechnol 2011 3 441-448 DOI: 10.1002/wnan.149 For further resources related to this article, please visit the WIREs website JF - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology AU - Schneider, Julie A AU - Grodzinski, Piotr AU - Liang, Xing-Jie AD - National Cancer Institute (NCI), NIH, Embassy of the United States, Beijing, PR China, schneidj@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 441 EP - 448 PB - Wiley-Blackwell, Baffins Lane Chichester W. Sussex PO19 1UD United Kingdom VL - 3 IS - 5 SN - 1939-0041, 1939-0041 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Conferences KW - Cooperation KW - Computed tomography KW - biomarkers KW - Cancer KW - nanotechnology KW - Public health KW - Joints KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017978439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.atitle=Cancer+nanotechnology+research+in+the+United+States+and+China%3A+cooperation+to+promote+innovation&rft.au=Schneider%2C+Julie+A%3BGrodzinski%2C+Piotr%3BLiang%2C+Xing-Jie&rft.aulast=Schneider&rft.aufirst=Julie&rft.date=2011-09-01&rft.volume=3&rft.issue=5&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.issn=19390041&rft_id=info:doi/10.1002%2Fwnan.149 L2 - http://onlinelibrary.wiley.com/doi/10.1002/wnan.149/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Drug delivery; Conferences; Cooperation; Computed tomography; biomarkers; Cancer; Joints; Public health; nanotechnology DO - http://dx.doi.org/10.1002/wnan.149 ER - TY - JOUR T1 - Directions in Human-Animal Interaction Research: Child Development, Health, and Therapeutic Interventions AN - 1010708593; 201208253 AB - Research on human-animal interaction (HAI) is a relatively new field of inquiry for developmental scientists seeking to understand the potential role pets play in children's health and well-being. It has been documented that pets offer a source of emotional support to children. However, most studies focusing on how animals affect children's health are limited and stop short of providing answers to key developmental questions. Addressing this need, beginning in 2008, scientists at the Eunice Kennedy Shriver National Institute of Child Health and Human Development, in collaboration with the Waltham Centre for Pet Nutrition, a subsidiary of the Mars Corporation, convened two international conferences of researchers to review the current science on HAI. These groups crafted a research agenda aimed at looking at how animal interaction affects children and promotes optimal development. This article reviews the key themes emerging from the conferences, addresses the application of HAI to child health and development, and discusses the potential of HAI as an important field of inquiry for developmental scientists. Adapted from the source document. JF - Child Development Perspectives AU - Esposito, Layla AU - McCune, Sandra AU - Griffin, James A AU - Maholmes, Valerie AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 205 EP - 211 PB - Wiley Publishing, Malden, MA 02148 VL - 5 IS - 3 SN - 1750-8592, 1750-8592 KW - Animals KW - Human development KW - Pets KW - Medical research KW - Health KW - Children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010708593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Development+Perspectives&rft.atitle=Directions+in+Human-Animal+Interaction+Research%3A+Child+Development%2C+Health%2C+and+Therapeutic+Interventions&rft.au=Esposito%2C+Layla%3BMcCune%2C+Sandra%3BGriffin%2C+James+A%3BMaholmes%2C+Valerie&rft.aulast=Esposito&rft.aufirst=Layla&rft.date=2011-09-01&rft.volume=5&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Child+Development+Perspectives&rft.issn=17508592&rft_id=info:doi/10.1111%2Fj.1750-8606.2011.00175.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Health; Children; Medical research; Pets; Animals; Human development DO - http://dx.doi.org/10.1111/j.1750-8606.2011.00175.x ER - TY - JOUR T1 - Relationships Among Health Perceptions Vary Depending on Stage of Readiness for Colorectal Cancer Screening AN - 1010707446; 201208280 AB - Objective: We explored whether relationships among health perceptions differ depending on individuals' stage of readiness for colorectal cancer screening (CRCS). Methods: Data from the National Cancer Institute's Health Information National Trends Survey (HINTS) were used to stage adults over 50 years of age (N = 2324) using a modified version of the Precaution Adoption Process Model (PAPM) staging algorithm. Health perceptions examined included perceived risk of cancer, worry about cancer, fatalism, and beliefs about ambiguity of cancer prevention recommendations. Results: Meaningful differences in patterns of relationships among health perceptions by stage were found. Conclusions: The nonlinear patterns that emerged indicate support for the role of these health perceptions in screening, the idea that behavioral readiness may moderate the relationship between important health perceptions, and the use of the stage construct in this context. [Copyright The American Psychological Association.] JF - Health Psychology AU - Ferrer, Rebecca A AU - Hall, Kara L AU - Portnoy, David B AU - Ling, Bruce S AU - Han, Paul K.J. AU - Klein, William M.P. AD - Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland ferrerra@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 525 EP - 535 PB - American Psychological Association, Washington DC VL - 30 IS - 5 SN - 0278-6133, 0278-6133 KW - health perceptions stage of readiness risk perceptions worry ambiguity fatalism KW - Screening KW - Perceptions KW - Readiness KW - Colorectal cancer KW - Health KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010707446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Psychology&rft.atitle=Relationships+Among+Health+Perceptions+Vary+Depending+on+Stage+of+Readiness+for+Colorectal+Cancer+Screening&rft.au=Ferrer%2C+Rebecca+A%3BHall%2C+Kara+L%3BPortnoy%2C+David+B%3BLing%2C+Bruce+S%3BHan%2C+Paul+K.J.%3BKlein%2C+William+M.P.&rft.aulast=Ferrer&rft.aufirst=Rebecca&rft.date=2011-09-01&rft.volume=30&rft.issue=5&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Health+Psychology&rft.issn=02786133&rft_id=info:doi/10.1037%2Fa0023583 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Perceptions; Health; Cancer; Screening; Colorectal cancer; Readiness DO - http://dx.doi.org/10.1037/a0023583 ER - TY - JOUR T1 - Pilot Test of an Emotional Education Intervention Component for Sexual Risk Reduction AN - 1010707443; 201208279 AB - Objective: Emotions are key predictors of sexual risk behavior but have been largely ignored in theory-based intervention development. The present study aims to evaluate whether the addition of an emotional education intervention component to a traditional social-cognitive safer sex intervention increases intervention efficacy, compared with both a social-cognitive only intervention and a no intervention control condition. Methods: Young adults were randomized in small groups to receive the social-cognitive-emotional (SCE) intervention, the social-cognitive (SC) intervention, or standard of care. Results: Analyses of data from 176 participants indicated that intervention arms reported similar increased condom use compared with the no intervention control arm at 3 months' postintervention (beta = .06, p = .41, d = 0.08). However, at 6 months' postintervention, individuals in the SCE intervention arm reported increased condom use compared with both the SC intervention (beta = .27, p = .04, d = 0.38) and control arms (beta = .37, p < .01; d = 0.56), demonstrating preliminary evidence that the addition of an emotional education component may facilitate sustained behavior change. Conclusions: An emotional education intervention module has the potential to facilitate sustained behavior change at delayed follow-up. Additional research is necessary to replicate findings in a larger sample and to determine the mediators of emotional education intervention efficacy. [Copyright The American Psychological Association.] JF - Health Psychology AU - Ferrer, Rebecca A AU - Fisher, Jeffrey D AU - Buck, Ross AU - Amico, K Rivet AD - Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland ferrerra@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 656 EP - 660 PB - American Psychological Association, Washington DC VL - 30 IS - 5 SN - 0278-6133, 0278-6133 KW - emotion intervention sexual risk reduction HIV prevention emotional education KW - Condoms KW - Emotions KW - Safe sexual practices KW - Efficacy KW - Behavioural changes KW - Arms KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010707443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Psychology&rft.atitle=Pilot+Test+of+an+Emotional+Education+Intervention+Component+for+Sexual+Risk+Reduction&rft.au=Ferrer%2C+Rebecca+A%3BFisher%2C+Jeffrey+D%3BBuck%2C+Ross%3BAmico%2C+K+Rivet&rft.aulast=Ferrer&rft.aufirst=Rebecca&rft.date=2011-09-01&rft.volume=30&rft.issue=5&rft.spage=656&rft.isbn=&rft.btitle=&rft.title=Health+Psychology&rft.issn=02786133&rft_id=info:doi/10.1037%2Fa0023438 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Safe sexual practices; Condoms; Behavioural changes; Efficacy; Arms; Emotions DO - http://dx.doi.org/10.1037/a0023438 ER - TY - JOUR T1 - A Query Expansion Framework in Image Retrieval Domain Based on Local and Global Analysis AN - 1010627447; 201204853 AB - We present an image retrieval framework based on automatic query expansion in a concept feature space by generalizing the vector space model of information retrieval. In this framework, images are represented by vectors of weighted concepts similar to the keyword-based representation used in text retrieval. To generate the concept vocabularies, a statistical model is built by utilizing Support Vector Machine (SVM)-based classification techniques. The images are represented as "bag of concepts" that comprise perceptually and/or semantically distinguishable color and texture patches from local image regions in a multi-dimensional feature space. To explore the correlation between the concepts and overcome the assumption of feature independence in this model, we propose query expansion techniques in the image domain from a new perspective based on both local and global analysis. For the local analysis, the correlations between the concepts based on the co-occurrence pattern, and the metrical constraints based on the neighborhood proximity between the concepts in encoded images, are analyzed by considering local feedback information. We also analyze the concept similarities in the collection as a whole in the form of a similarity thesaurus and propose an efficient query expansion based on the global analysis. The experimental results on a photographic collection of natural scenes and a biomedical database of different imaging modalities demonstrate the effectiveness of the proposed framework in terms of precision and recall. Adapted from the source document. JF - Information Processing and Management AU - Rahman, M M AU - Antani, S K AU - Thoma, G R AD - U.S. National Library of Medicine, National Institutes of Health Bethesda, MD, USA rahmanmm@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 676 EP - 691 PB - Elsevier Ltd., Kidlington Oxford UK VL - 47 IS - 5 SN - 0306-4573, 0306-4573 KW - Image retrieval, vector space model, support vector machine, relevance feedback, query expansion KW - Information retrieval KW - Image retrieval KW - Relevance feedback KW - Query expansion KW - article KW - 13.13: AUTOMATIC TEXT ANALYSIS, AUTOMATIC INDEXING, MACHINE TRANSLATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010627447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Information+Processing+and+Management&rft.atitle=A+Query+Expansion+Framework+in+Image+Retrieval+Domain+Based+on+Local+and+Global+Analysis&rft.au=Rahman%2C+M+M%3BAntani%2C+S+K%3BThoma%2C+G+R&rft.aulast=Rahman&rft.aufirst=M&rft.date=2011-09-01&rft.volume=47&rft.issue=5&rft.spage=676&rft.isbn=&rft.btitle=&rft.title=Information+Processing+and+Management&rft.issn=03064573&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Query expansion; Image retrieval; Relevance feedback; Information retrieval ER - TY - JOUR T1 - Toxicokinetics of bis(2-chloroethoxy)methane following intravenous administration and dermal application in male and female F344/N rats and B6C3F1 mice AN - 883022542; 15380548 AB - In the National Toxicology Program's toxicity studies, rats were more sensitive than mice to Bis(2-chloroethoxy)methane (CEM) - induced cardiac toxicity following dermal application to male and female F344/N rats and B6C3F1 mice. Thiodiglycolic acid (TDGA) is a major metabolite of CEM in rats. It has been implicated that chemicals metabolized to TDGA cause cardiac toxicity in humans. Therefore, the toxicokinetics of CEM and TDGA were investigated in male and female F344/N rats and B6C3F1 mice following a single intravenous administration or dermal application of CEM to aid in the interpretation of the toxicity data. Absorption of CEM following dermal application was rapid in both species and genders. Bioavailability following dermal application was low but was higher in rats than in mice with females of both species showing higher bioavailability than males. CEM was rapidly distributed to the heart, thymus, and liver following both routes of administration. Plasma CEM Cmax and AUC( infinity ) increased proportionally with dose, although at the dermal dose of 400mg/kg in rats and 600mg/kg in mice non-linear kinetics were apparent. Following dermal application, dose-normalized plasma CEM C JF - Toxicology Letters AU - Waidyanatha, S AU - Johnson, J D AU - Hong, S P AU - Godfrey-Robinson, V D AU - Graves, S W AU - Cristy, T AU - Dunnick, J K AU - Smith, C S Y1 - 2011/08/28/ PY - 2011 DA - 2011 Aug 28 SP - 215 EP - 226 PB - Elsevier B.V., Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland VL - 205 IS - 2 SN - 0378-4274, 0378-4274 KW - Environment Abstracts; Toxicology Abstracts KW - CEM KW - TDGA KW - GC KW - MS KW - Bis(2-chloroethoxy)methane KW - Thiodiglycolic acid KW - Bioavailability KW - Toxicokinetics KW - Metabolism KW - Chemicals KW - Heart KW - Intravenous administration KW - Skin KW - Data processing KW - Thymus KW - thiodiglycolic acid KW - Mice KW - Metabolites KW - Toxicity KW - Rats KW - Kinetics KW - Absorption KW - Liver KW - intravenous administration KW - X 24300:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883022542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Toxicokinetics+of+bis%282-chloroethoxy%29methane+following+intravenous+administration+and+dermal+application+in+male+and+female+F344%2FN+rats+and+B6C3F1+mice&rft.au=Waidyanatha%2C+S%3BJohnson%2C+J+D%3BHong%2C+S+P%3BGodfrey-Robinson%2C+V+D%3BGraves%2C+S+W%3BCristy%2C+T%3BDunnick%2C+J+K%3BSmith%2C+C+S&rft.aulast=Waidyanatha&rft.aufirst=S&rft.date=2011-08-28&rft.volume=205&rft.issue=2&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2011.06.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Heart; Bioavailability; Intravenous administration; Data processing; Skin; Kinetics; Thymus; thiodiglycolic acid; Liver; Metabolites; Toxicity; Chemicals; Rats; Absorption; Mice; intravenous administration DO - http://dx.doi.org/10.1016/j.toxlet.2011.06.012 ER - TY - JOUR T1 - Catechol-o-methyl transferase (COMT) val super(158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls) AN - 885051292; 15458519 AB - Non-psychotic individuals at increased risk for schizophrenia show alterations in fronto-striatal dopamine signaling and cortical gray matter maturation reminiscent of those seen in schizophrenia. It remains unclear however if variations in dopamine signaling influence rates of structural cortical maturation in typically developing individuals, and whether such influences are disrupted in patients with schizophrenia and their non-psychotic siblings. We sought to address these issues by relating a functional Val -- Met polymorphism within the gene encoding catechol-o-methyltransferase (COMT) - a key enzymatic regulator of cortical dopamine levels - to longitudinal structural neuroimaging measures of cortical gray matter thickness. We included a total of 792 magnetic resonance imaging brain scans, acquired between ages 9 and 22 years from patients with childhood-onset schizophrenia (COS), their non-psychotic full siblings, and matched healthy controls. Whereas greater Val allele dose (which confers enhanced dopamine catabolism and is proposed to aggravate cortical deficits in schizophrenia) accelerated adolescent cortical thinning in both schizophrenia probands and their siblings, it attenuated cortical thinning in healthy controls. This similarity between COS patients and their siblings was accompanied by differences between the two groups in the timing and spatial distribution of disrupted COMT influences on cortical maturation. Consequently, whereas greater Val "dose" conferred persistent dorsolateral prefrontal cortical deficits amongst affected probands by adulthood, cortical thickness differences associated with varying Val dose in non-psychotic siblings resolved over the age-range studied. These findings suggest that cortical abnormalities in pedigrees affected by schizophrenia may be contributed to by a disruption of dopaminergic infleunces on cortical maturation. JF - NeuroImage AU - Raznahan, Armin AU - Greenstein, Deanna AU - Lee, Yohan AU - Long, Robert AU - Clasen, Liv AU - Gochman, Pete AU - Addington, Anjene AU - Giedd, Jay N AU - Rapoport, Judith L AU - Gogtay, Nitin Y1 - 2011/08/15/ PY - 2011 DA - 2011 Aug 15 SP - 1517 EP - 1523 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 57 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Adolescence KW - Schizophrenia KW - W 30910:Imaging KW - N3:11001 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885051292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Catechol-o-methyl+transferase+%28COMT%29+val+super%28158met+polymorphism+and+adolescent+cortical+development+in+patients+with+childhood-onset+schizophrenia%2C+their+non-psychotic+siblings%2C+and+healthy+controls%29&rft.au=Raznahan%2C+Armin%3BGreenstein%2C+Deanna%3BLee%2C+Yohan%3BLong%2C+Robert%3BClasen%2C+Liv%3BGochman%2C+Pete%3BAddington%2C+Anjene%3BGiedd%2C+Jay+N%3BRapoport%2C+Judith+L%3BGogtay%2C+Nitin&rft.aulast=Raznahan&rft.aufirst=Armin&rft.date=2011-08-15&rft.volume=57&rft.issue=4&rft.spage=1517&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2011.05.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Schizophrenia DO - http://dx.doi.org/10.1016/j.neuroimage.2011.05.032 ER - TY - JOUR T1 - Smoking before the first pregnancy and the risk of breast cancer: a meta-analysis. AN - 881086439; 21719745 AB - The authors conducted a meta-analysis of the association between smoking before a first pregnancy, when undifferentiated breast tissue may be vulnerable to tobacco carcinogens, and the risk of breast cancer. A search of the published literature through August 2010 identified 23 papers reporting on associations between smoking before a first pregnancy and breast cancer. Odds ratios or hazard ratios and 95% confidence intervals, adjusted for known or suspected breast cancer risk factors, were abstracted from each study. Data were pooled using both fixed- and random-effects models. The fixed-effect summary risk ratio for breast cancer among the women who smoked before their first pregnancy versus women who had never smoked was 1.10 (95% confidence interval: 1.07, 1.14); the random-effects estimate was similar. The separate fixed-effect risk ratios for smoking only before the first pregnancy (5 studies) or only after the first pregnancy (16 studies) were both 1.07, providing no evidence that breast tissue is more susceptible to malignant transformation from smoking before the first pregnancy. While these small summary risk ratios may represent causal effects, residual confounding could readily produce estimates of this size in the absence of any causal effect. JF - American journal of epidemiology AU - DeRoo, Lisa A AU - Cummings, Peter AU - Mueller, Beth A AD - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle,Washington, USA. DeRooL@niehs.nih.gov Y1 - 2011/08/15/ PY - 2011 DA - 2011 Aug 15 SP - 390 EP - 402 VL - 174 IS - 4 KW - Index Medicus KW - Parity KW - Risk Factors KW - Humans KW - Incidence KW - Female KW - Pregnancy KW - Breast Neoplasms -- etiology KW - Smoking -- adverse effects KW - Breast Neoplasms -- epidemiology KW - Smoking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881086439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Smoking+before+the+first+pregnancy+and+the+risk+of+breast+cancer%3A+a+meta-analysis.&rft.au=DeRoo%2C+Lisa+A%3BCummings%2C+Peter%3BMueller%2C+Beth+A&rft.aulast=DeRoo&rft.aufirst=Lisa&rft.date=2011-08-15&rft.volume=174&rft.issue=4&rft.spage=390&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwr090 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-27 N1 - Date created - 2011-08-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 2007 Nov 5;97(9):1287-90 [17912245] Epidemiology. 2007 Sep;18(5):629-38 [17700252] Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):1-2 [18187387] Breast Cancer Res Treat. 2008 May;109(1):101-11 [17594514] Breast Cancer Res Treat. 2008 May;109(1):67-75 [17972172] BMC Cancer. 2008;8:157 [18518960] Ann Epidemiol. 2011 Jan;21(1):53-5 [21130370] Am J Epidemiol. 1996 May 1;143(9):918-28 [8610705] Stat Med. 2000 Dec 30;19(24):3325-36 [11122498] Microsc Res Tech. 2001 Jan 15;52(2):204-23 [11169868] Cancer Causes Control. 2001 Feb;12(2):179-85 [11246847] Epidemiology. 2002 Mar;13(2):138-45 [11880753] Breast Cancer Res Treat. 2002 Sep;75(2):181-4 [12243511] Am J Epidemiol. 2002 Oct 1;156(7):616-26 [12244030] Lancet. 2002 Oct 5;360(9339):1044-9 [12383984] Br J Cancer. 2002 Nov 18;87(11):1234-45 [12439712] Cancer Causes Control. 2003 Feb;14(1):43-51 [12708724] Cancer Causes Control. 2003 Jun;14(5):497-503 [12946045] BMJ. 2003 Sep 6;327(7414):557-60 [12958120] J Natl Cancer Inst. 2004 Jan 7;96(1):29-37 [14709736] Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):398-404 [15006915] Int J Cancer. 2004 Jun 20;110(3):413-6 [15095307] Br J Cancer. 2004 Aug 2;91(3):512-8 [15226777] Environ Res. 2004 Oct;96(2):176-85 [15325878] Control Clin Trials. 1986 Sep;7(3):177-88 [3802833] Br J Cancer. 1988 Dec;58(6):832-7 [3224085] Epidemiol Rev. 1992;14:154-76 [1289110] Cancer Epidemiol Biomarkers Prev. 1994 Jun;3(4):353-64 [8061586] Biometrics. 1994 Dec;50(4):1088-101 [7786990] BMJ. 1997 Sep 13;315(7109):629-34 [9310563] Carcinogenesis. 1997 Nov;18(11):2127-32 [9395212] Cancer Res. 1998 Feb 15;58(4):667-71 [9485019] Am J Epidemiol. 1999 Jan 1;149(1):5-12 [9883788] Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):61-6 [15668477] Cancer Causes Control. 2005 Oct;16(8):975-85 [16132806] Mayo Clin Proc. 2005 Nov;80(11):1423-8 [16295021] Int J Cancer. 2006 Oct 15;119(8):1961-9 [16721725] Breast Cancer Res Treat. 2006 Dec;100(3):293-9 [16773435] Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):620-2 [17372262] Am J Epidemiol. 2007 Jul 1;166(1):55-61 [17426039] BMJ. 2007 Nov 3;335(7626):914-6 [17974687] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwr090 ER - TY - JOUR T1 - We don't know what we don't study: the case for research on medication effects in pregnancy. AN - 878593961; 21766436 AB - This Commentary addresses issues related to exposures to teratogens and makes the case for increased research into the safety of medication usage during pregnancy for mothers and fetuses. Not only are medications commonly used during pregnancy, but evidence points to an increasing prevalence and number of drug exposures experienced by the embryo or fetus, particularly during the critical first trimester of pregnancy. Although the first trimester represents a particularly vulnerable period of organogenesis, exposures during other gestational time periods may also be associated with deleterious outcomes. In addition to the changing (and in many cases unknown) risks to a developing fetus, other challenges to studying medication exposures and their effects during pregnancy include the dramatic changes in physiology that occur in pregnant women and the ethical dilemmas posed by including this vulnerable population in randomized controlled trials of safety and efficacy. However, without adequate knowledge of the pharmacokinetics, pharmacodynamics, efficacy, and safety of medication use in pregnancy, women may be under-dosed to minimize exposure or not treated at all, resulting in inadequate treatment and potential harm to the mother and her baby. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) is undertaking studies on medications and teratogenic exposures during pregnancy, including alcohol, maternal diabetes, oral hypoglycemic agents, and antiviral medications, through several of its research networks. Although this is a start, there is a critical need for further research on medications used during pregnancy, especially their effects on both the mother and her developing child. Published 2011 Wiley-Liss, Inc. JF - American journal of medical genetics. Part C, Seminars in medical genetics AU - Parisi, Melissa A AU - Spong, Catherine Y AU - Zajicek, Anne AU - Guttmacher, Alan E AD - Intellectual and Developmental Disabilities Branch, Center for Developmental Biology and Perinatal Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Boulevard, Bethesda, MD 20892-7510, USA. parisima@mail.nih.gov Y1 - 2011/08/15/ PY - 2011 DA - 2011 Aug 15 SP - 247 EP - 250 VL - 157C IS - 3 KW - Teratogens KW - 0 KW - Index Medicus KW - Prenatal Exposure Delayed Effects -- prevention & control KW - Prenatal Exposure Delayed Effects -- chemically induced KW - Humans KW - Pregnancy Complications -- drug therapy KW - Abnormalities, Drug-Induced -- etiology KW - Abnormalities, Drug-Induced -- prevention & control KW - Female KW - Risk Assessment KW - Pregnancy Outcome KW - Pregnancy KW - Drug-Related Side Effects and Adverse Reactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878593961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+medical+genetics.+Part+C%2C+Seminars+in+medical+genetics&rft.atitle=We+don%27t+know+what+we+don%27t+study%3A+the+case+for+research+on+medication+effects+in+pregnancy.&rft.au=Parisi%2C+Melissa+A%3BSpong%2C+Catherine+Y%3BZajicek%2C+Anne%3BGuttmacher%2C+Alan+E&rft.aulast=Parisi&rft.aufirst=Melissa&rft.date=2011-08-15&rft.volume=157C&rft.issue=3&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=American+journal+of+medical+genetics.+Part+C%2C+Seminars+in+medical+genetics&rft.issn=1552-4876&rft_id=info:doi/10.1002%2Fajmg.c.30309 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-23 N1 - Date created - 2011-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Public Health. 2009 Oct;99 Suppl 2:S248-54 [19461110] Aust N Z J Obstet Gynaecol. 2009 Apr;49(2):168-72 [19432605] Science. 2010 Jan 1;327(5961):36-7 [20044560] Am J Obstet Gynecol. 2011 Jun;204(6 Suppl 1):S89-93 [21492824] Am J Obstet Gynecol. 2011 Jun;204(6 Suppl 1):S84-8 [21492826] Am J Med Genet C Semin Med Genet. 2011 Aug 15;157C(3):175-82 [21766440] Am J Obstet Gynecol. 2011 Jul;205(1):51.e1-8 [21514558] Teratology. 2000 Apr;61(4):314-7 [10716751] J Psychiatry Neurosci. 2001 Jan;26(1):44-8 [11212593] N Engl J Med. 2004 Jul 15;351(3):241-9 [15254282] Am J Obstet Gynecol. 2004 Aug;191(2):398-407 [15343213] Teratology. 1990 Jun;41(6):657-61 [2353314] JAMA. 2006 Feb 1;295(5):499-507 [16449615] N Engl J Med. 2006 Feb 9;354(6):579-87 [16467545] Clin Pharmacol Ther. 2007 Apr;81(4):547-56 [17329990] Birth Defects Res A Clin Mol Teratol. 2007 Apr;79(4):301-8 [17216624] N Engl J Med. 2007 Jun 28;356(26):2675-83 [17596601] N Engl J Med. 2007 Jun 28;356(26):2684-92 [17596602] Clin Pharmacol Ther. 2008 Jan;83(1):181-3 [18073777] PLoS Med. 2008 Jan 22;5(1):e22 [18215109] Birth Defects Res A Clin Mol Teratol. 2009 Jan;85(1):63-8 [19107954] Obstet Gynecol. 2009 Oct;114(4):885-91 [19888049] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ajmg.c.30309 ER - TY - JOUR T1 - Nitric oxide donor, V-PROLI/NO, provides protection against arsenical induced toxicity in rat liver cells: requirement for Cyp1a1. AN - 874898175; 21621526 AB - Arsenic is a cancer chemotherapeutic but hepatotoxicity can be a limiting side effect. O(2)-vinyl 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (V-PROLI/NO) is a nitric oxide (NO) donor prodrug and metabolized by liver cytochromes P450 (CYP450) to release NO. The effects of V-PROLI/NO pretreatment on the toxicity of arsenic (as NaAsO(2)) were studied in a rat liver cell line (TRL 1215). The cells acted upon the prodrug to release NO, as assessed by nitrite levels, in a time-dependent fashion to maximal levels of 8-fold above basal levels. Pretreatment with V-PROLI/NO markedly reduced arsenic cytolethality which was directly related to the level of NO produced by V-PROLI/NO treatment. Cyp1a1 expression was directly related to the level of NO production and to reduced arsenic cytotoxicity. V-PROLI/NO pretreatment markedly reduced arsenic-induced apoptosis and suppressed phosphorylation of JNK1/2. V-PROLI/NO pretreatment facilitated additional increases in arsenic-induced metallothionein, a metal-binding protein important in arsenic tolerance. Thus, V-PROLI/NO protects against arsenic toxicity in rat liver cells, reducing cytolethality, apoptosis and dysregulation of MAPKs, through generation of NO formed after metabolism by liver cell enzymes, possibly including Cyp1a1. CYP450 required for NO production from V-PROLI/NO treatment in the rat and human appears to differ as we have previously studied the ability of V-PROLI/NO to prevent arsenic toxicity in human liver cells where it reduced toxicity apparently through a CYP2E1-mediated metabolic mechanism. None-the-less, it appears that both rat and human liver cells act upon V-PROLI/NO via a CYP450-related mechanism to produce NO and subsequently reduce arsenic toxicity. Published by Elsevier Ireland Ltd. JF - Chemico-biological interactions AU - Qu, Wei AU - Cheng, Lida AU - Dill, Anna L AU - Saavedra, Joseph E AU - Hong, Sam Y AU - Keefer, Larry K AU - Waalkes, Michael P AD - National Toxicology Program, National Institute of Environmental Health Sciences and Laboratory of Comparative Carcinogenesis, National Cancer Institute, 111 Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2011/08/15/ PY - 2011 DA - 2011 Aug 15 SP - 88 EP - 96 VL - 193 IS - 1 KW - Nitric Oxide Donors KW - 0 KW - O2-vinyl 1-(2-(carboxylato)pyrrolidin-1-yl)diazen-1-ium-1,2-diolate KW - Prodrugs KW - Pyrrolidines KW - Triazenes KW - Nitric Oxide KW - 31C4KY9ESH KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - MAP Kinase Kinase 4 KW - EC 2.7.12.2 KW - MAP Kinase Kinase 7 KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Rats KW - MAP Kinase Kinase 7 -- metabolism KW - Animals KW - Apoptosis KW - Mitogen-Activated Protein Kinases -- metabolism KW - Nitric Oxide -- metabolism KW - MAP Kinase Kinase 4 -- metabolism KW - Cell Line KW - Triazenes -- pharmacology KW - Cytochrome P-450 CYP1A1 -- genetics KW - Hepatocytes -- drug effects KW - Arsenic -- toxicity KW - Prodrugs -- chemistry KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Nitric Oxide Donors -- pharmacology KW - Prodrugs -- pharmacology KW - Pyrrolidines -- chemistry KW - Pyrrolidines -- pharmacology KW - Triazenes -- chemistry KW - Hepatocytes -- metabolism KW - Nitric Oxide Donors -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874898175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Nitric+oxide+donor%2C+V-PROLI%2FNO%2C+provides+protection+against+arsenical+induced+toxicity+in+rat+liver+cells%3A+requirement+for+Cyp1a1.&rft.au=Qu%2C+Wei%3BCheng%2C+Lida%3BDill%2C+Anna+L%3BSaavedra%2C+Joseph+E%3BHong%2C+Sam+Y%3BKeefer%2C+Larry+K%3BWaalkes%2C+Michael+P&rft.aulast=Qu&rft.aufirst=Wei&rft.date=2011-08-15&rft.volume=193&rft.issue=1&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=1872-7786&rft_id=info:doi/10.1016%2Fj.cbi.2011.05.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-09 N1 - Date created - 2011-07-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Med Chem. 1996 Oct 25;39(22):4361-5 [8893830] J Biol Chem. 1996 Jun 28;271(26):15703-7 [8663189] J Med Chem. 1997 Jun 20;40(13):1947-54 [9207935] Anesthesiology. 1998 Jan;88(1):190-5 [9447872] Am J Physiol. 1998 Sep;275(3 Pt 1):L551-8 [9728050] Annu Rev Pharmacol Toxicol. 1999;39:267-94 [10331085] Cancer Res. 1999 Jul 1;59(13):3053-8 [10397243] Toxicol Sci. 1999 Jun;49(2):156-64 [10416260] J Pharm Sci. 2006 Jan;95(1):108-15 [16315224] Leukemia. 2006 May;20(5):881-3 [16525498] Nitric Oxide. 2006 Jun;14(4):309-15 [16545970] J Am Chem Soc. 2006 Sep 27;128(38):12473-83 [16984198] J Natl Cancer Inst. 2007 May 2;99(9):667-8 [17470732] Environ Health Perspect. 2007 Jul;115(7):1101-6 [17637929] Org Lett. 2007 Aug 16;9(17):3409-12 [17658755] Acta Pharmacol Sin. 2007 Sep;28(9):1429-33 [17723176] Cancer Lett. 2007 Oct 28;256(2):238-45 [17658681] Biochem Soc Trans. 2007 Nov;35(Pt 5):1364-8 [17956352] Biochemistry. 2008 Feb 26;47(8):2231-43 [18237198] Blood. 2008 Mar 1;111(5):2505-15 [18299451] Toxicol Appl Pharmacol. 2008 Jun 1;229(2):252-61 [18328521] Toxicol Sci. 2008 Sep;105(1):24-32 [18566022] Cancer Sci. 2009 Mar;100(3):382-8 [19154403] Expert Opin Drug Metab Toxicol. 2009 May;5(5):501-21 [19416086] BMC Cancer. 2009;9:187 [19531241] J Natl Cancer Inst. 2009 Dec 16;101(24):1670-81 [19933942] Toxicol Appl Pharmacol. 2010 May 1;244(3):291-9 [20083128] Toxicol Sci. 2000 Jun;55(2):460-7 [10828279] Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14382-7 [11121042] Biol Trace Elem Res. 2000 Winter;78(1-3):241-54 [11314982] Toxicol Lett. 2001 Feb 28;119(2):103-8 [11311571] Toxicol Sci. 2001 Oct;63(2):189-95 [11568362] Carcinogenesis. 2002 Jan;23(1):151-9 [11756236] Annu Rev Pharmacol Toxicol. 2003;43:585-607 [12415121] Chem Res Toxicol. 2003 Jul;16(7):873-80 [12870890] J Biol Chem. 2004 Jul 30;279(31):32700-8 [15161912] Toxicol Appl Pharmacol. 1982 Oct;66(1):134-42 [7157381] Fundam Appl Toxicol. 1993 Feb;20(2):184-9 [8449390] Science. 1995 Nov 24;270(5240):1326-31 [7481820] Blood. 1997 May 1;89(9):3354-60 [9129042] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.cbi.2011.05.005 ER - TY - JOUR T1 - Risk factors for non-Hodgkin lymphoma subtypes defined by histology and t(14; 18) in a population-based case-control study AN - 1017961459; 16689862 AB - The t(14; 18) chromosomal translocation is the most common cytogenetic abnormality in non-Hodgkin lymphoma (NHL), occurring in 70-90% of follicular lymphomas (FL) and 30-50% of diffuse large B-cell lymphomas (DLBCL). Previous t(14; 18)-NHL studies have not evaluated risk factors for NHL defined by both t(14; 18) status and histology. In this population-based case-control study, t(14; 18) status was determined in DLBCL cases using fluorescence in situ hybridization on paraffin-embedded tumor sections. Polytomous logistic regression was used to evaluate the association between a wide variety of exposures and t(14; 18)-positive (N = 109) and -negative DLBCL (N = 125) and FL (N = 318), adjusting for sex, age, race, and study center. Taller height, more lifetime surgeries, and PCB180 exposure were associated with t(14; 18)-positivity. Taller individuals (third tertile vs. first tertile) had elevated risks of t(14; 18)-positive DLBCL (odds ratio [OR] = 1.8, 95% confidence interval [CI] 1.1-3.0) and FL (OR = 1.4, 95%CI 1.0-1.9) but not t(14; 18)-negative DLBCL. Similar patterns were seen for individuals with more lifetime surgeries (13+ vs. 0-12 surgeries; t(14; 18)-positive DLBCL OR = 1.4, 95%CI 0.7-2.7; FL OR = 1.6, 95%CI 1.1-2.5) and individuals exposed to PCB180 greater than 20.8 ng/g (t(14; 18)-positive DLBCL OR = 1.3, 95%CI 0.6-2.9; FL OR = 1.7, 95%CI 1.0-2.8). In contrast, termite treatment and high alpha-chlordane levels were associated with t(14; 18)-negative DLBCL only, suggesting that these exposures do not act through t(14; 18). Our findings suggest that putative associations between NHL and height, surgeries, and PCB180 may be t(14; 18)-mediated and provide support for case-subtyping based on molecular and histologic subtypes. Future efforts should focus on pooling data to confirm and extend previous research on risk factors for t(14; 18)-NHL subtypes. JF - International Journal of Cancer AU - Chang, Cindy M AU - Wang, Sophia S AU - Dave, Bhavana J AU - Jain, Smrati AU - Vasef, Mohammad A AU - Weisenburger, Dennis D AU - Cozen, Wendy AU - Davis, Scott AU - Severson, Richard K AU - Lynch, Charles F AU - Rothman, Nathaniel AU - Cerhan, James R AU - Hartge, Patricia AU - Morton, Lindsay M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, changcm@mail.nih.gov Y1 - 2011/08/15/ PY - 2011 DA - 2011 Aug 15 SP - 938 EP - 947 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 129 IS - 4 SN - 1097-0215, 1097-0215 KW - Immunology Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Cancer KW - Chromosome translocations KW - Data processing KW - Fluorescence KW - Fluorescence in situ hybridization KW - Histology KW - Races KW - Risk factors KW - Sex KW - Surgery KW - Translocation KW - Tumors KW - double prime B-cell lymphoma KW - lymphoma KW - non-Hodgkin's lymphoma KW - surgery KW - translocation KW - tumors KW - Isoptera KW - H 11000:Diseases/Injuries/Trauma KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017961459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Risk+factors+for+non-Hodgkin+lymphoma+subtypes+defined+by+histology+and+t%2814%3B+18%29+in+a+population-based+case-control+study&rft.au=Chang%2C+Cindy+M%3BWang%2C+Sophia+S%3BDave%2C+Bhavana+J%3BJain%2C+Smrati%3BVasef%2C+Mohammad+A%3BWeisenburger%2C+Dennis+D%3BCozen%2C+Wendy%3BDavis%2C+Scott%3BSeverson%2C+Richard+K%3BLynch%2C+Charles+F%3BRothman%2C+Nathaniel%3BCerhan%2C+James+R%3BHartge%2C+Patricia%3BMorton%2C+Lindsay+M&rft.aulast=Chang&rft.aufirst=Cindy&rft.date=2011-08-15&rft.volume=129&rft.issue=4&rft.spage=938&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=10970215&rft_id=info:doi/10.1002%2Fijc.25717 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ijc.25717/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Age; Data processing; double prime B-cell lymphoma; Chromosome translocations; Risk factors; Surgery; Tumors; Races; Sex; Fluorescence in situ hybridization; non-Hodgkin's lymphoma; Fluorescence; Histology; tumors; translocation; Translocation; lymphoma; Cancer; surgery; Isoptera DO - http://dx.doi.org/10.1002/ijc.25717 ER - TY - JOUR T1 - Structural basis of M3 muscarinic receptor dimer/oligomer formation. AN - 883311900; 21685385 AB - Class A G protein-coupled receptors (GPCRs) are known to form dimers and/or oligomeric arrays in vitro and in vivo. These complexes are thought to play important roles in modulating class A GPCR function. Many studies suggest that residues located on the "outer" (lipid-facing) surface of the transmembrane (TM) receptor core are critically involved in the formation of class A receptor dimers (oligomers). However, no clear consensus has emerged regarding the identity of the TM helices or TM subsegments involved in this process. To shed light on this issue, we have used the M(3) muscarinic acetylcholine receptor (M3R), a prototypic class A GPCR, as a model system. Using a comprehensive and unbiased approach, we subjected all outward-facing residues (70 amino acids total) of the TM helical bundle (TM1-7) of the M3R to systematic alanine substitution mutagenesis. We then characterized the resulting mutant receptors in radioligand binding and functional studies and determined their ability to form dimers (oligomers) in bioluminescence resonance energy transfer saturation assays. We found that M3R/M3R interactions are not dependent on the presence of one specific structural motif but involve the outer surfaces of multiple TM subsegments (TM1-5 and -7) located within the central and endofacial portions of the TM receptor core. Moreover, we demonstrated that the outward-facing surfaces of most TM helices play critical roles in proper receptor folding and/or function. Guided by the bioluminescence resonance energy transfer data, molecular modeling studies suggested the existence of multiple dimeric/oligomeric M3R arrangements, which may exist in a dynamic equilibrium. Given the high structural homology found among all class A GPCRs, our results should be of considerable general relevance. JF - The Journal of biological chemistry AU - McMillin, Sara M AU - Heusel, Moritz AU - Liu, Tong AU - Costanzi, Stefano AU - Wess, Jürgen AD - Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health,Bethesda, Maryland 20892, USA. Y1 - 2011/08/12/ PY - 2011 DA - 2011 Aug 12 SP - 28584 EP - 28598 VL - 286 IS - 32 KW - Receptor, Muscarinic M3 KW - 0 KW - Index Medicus KW - Structural Homology, Protein KW - Animals KW - Peptide Mapping KW - COS Cells KW - Amino Acid Motifs KW - Humans KW - Cercopithecus aethiops KW - Amino Acid Substitution KW - Mutagenesis KW - Protein Multimerization -- physiology KW - Protein Folding KW - Receptor, Muscarinic M3 -- metabolism KW - Receptor, Muscarinic M3 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883311900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Structural+basis+of+M3+muscarinic+receptor+dimer%2Foligomer+formation.&rft.au=McMillin%2C+Sara+M%3BHeusel%2C+Moritz%3BLiu%2C+Tong%3BCostanzi%2C+Stefano%3BWess%2C+J%C3%BCrgen&rft.aulast=McMillin&rft.aufirst=Sara&rft.date=2011-08-12&rft.volume=286&rft.issue=32&rft.spage=28584&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M111.259788 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-11 N1 - Date created - 2011-08-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 1993 Jan;12(1):331-8 [7679072] Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):3103-7 [8385357] J Biol Chem. 1994 Jan 7;269(1):402-5 [8276826] J Biol Chem. 1995 Jul 28;270(30):18000-6 [7629108] J Biol Chem. 1996 Jul 5;271(27):16384-92 [8663163] Crit Rev Neurobiol. 1996;10(1):69-99 [8853955] Pharmacol Rev. 1998 Jun;50(2):279-90 [9647869] Pharmacol Ther. 1998 Dec;80(3):231-64 [9888696] J Biol Chem. 1999 Jul 2;274(27):19487-97 [10383466] Brain Res Mol Brain Res. 2005 Jan 5;133(1):6-11 [15661360] J Biol Chem. 2005 Feb 18;280(7):5664-75 [15572356] FEBS J. 2005 Jun;272(12):2926-38 [15955053] Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17495-500 [16301531] Nat Methods. 2006 Mar;3(3):165-74 [16489332] J Biol Chem. 2006 Mar 3;281(9):5416-25 [16368694] Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3054-9 [16492774] Cell Metab. 2006 Jun;3(6):449-61 [16753580] Nat Methods. 2007 Feb;4(2):169-74 [17206152] Pharmacol Rev. 2007 Mar;59(1):5-13 [17329545] Mol Pharmacol. 2007 Apr;71(4):1015-29 [17220353] Biochim Biophys Acta. 2007 Apr;1768(4):825-35 [17069751] Proc Natl Acad Sci U S A. 2007 May 1;104(18):7682-7 [17452637] J Struct Biol. 2007 Jun;158(3):455-62 [17374491] Nat Rev Drug Discov. 2007 Sep;6(9):721-33 [17762886] J Biol Chem. 2007 Oct 19;282(42):30363-72 [17726027] Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18303-8 [17989235] J Biol Chem. 2008 Feb 15;283(7):4387-94 [18033822] Nat Rev Drug Discov. 2008 Apr;7(4):339-57 [18382464] Trends Pharmacol Sci. 2008 May;29(5):234-40 [18384890] Cancer Res. 2008 May 15;68(10):3573-8 [18483237] Nature. 2008 Jul 24;454(7203):486-91 [18594507] EMBO J. 2008 Sep 3;27(17):2293-304 [18668123] Nat Methods. 2009 Mar;6(3):225-30 [19234451] Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6398-403 [19332789] FEBS J. 2009 May;276(10):2786-800 [19459935] Mol Pharmacol. 2009 Jun;75(6):1296-9 [19273553] Mol Pharmacol. 2009 Aug;76(2):264-74 [19429716] Nat Chem Biol. 2009 Sep;5(9):688-95 [19648932] EMBO J. 2009 Nov 4;28(21):3315-28 [19763081] J Physiol. 2009 Nov 15;587(Pt 22):5337-44 [19723778] Nature. 2010 Jan 7;463(7277):108-12 [20054398] Trends Pharmacol Sci. 2010 Jan;31(1):15-21 [19963287] Curr Opin Pharmacol. 2010 Feb;10(1):23-9 [19850521] Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2693-8 [20133736] Cell Metab. 2010 Mar 3;11(3):231-8 [20197056] J Biol Chem. 2010 Apr 16;285(16):12435-44 [20172855] J Biol Chem. 2010 May 28;285(22):16723-38 [20304928] Nat Chem Biol. 2010 Jul;6(7):541-8 [20512139] Nat Chem Biol. 2010 Aug;6(8):587-94 [20622858] Trends Biotechnol. 2010 Aug;28(8):407-15 [20542584] Trends Biochem Sci. 2010 Nov;35(11):595-600 [20538466] Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12199-204 [17620610] Science. 2000 Mar 17;287(5460):1960-4 [10720314] Neuron. 2000 Jul;27(1):97-106 [10939334] Annu Rev Pharmacol Toxicol. 2002;42:409-35 [11807178] J Mol Biol. 2001 Nov 30;314(3):455-63 [11846559] Nat Rev Mol Cell Biol. 2002 Sep;3(9):639-50 [12209124] J Biol Chem. 2002 Nov 22;277(47):44925-31 [12244098] Nature. 2003 Jan 9;421(6919):127-8 [12520290] J Biol Chem. 2003 Feb 14;278(7):4385-8 [12496294] Mol Endocrinol. 2003 Apr;17(4):677-91 [12554793] J Biol Chem. 2003 Jun 13;278(24):21655-62 [12663652] J Biol Chem. 2003 Sep 12;278(37):35345-53 [12835319] Nat Immunol. 2004 Feb;5(2):216-23 [14716309] FEBS Lett. 2004 Apr 30;564(3):281-8 [15111110] J Biol Chem. 2004 Jul 2;279(27):28756-65 [15123695] Mol Pharmacol. 2004 Aug;66(2):312-21 [15266022] Mol Pharmacol. 2004 Nov;66(5):1123-37 [15304550] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M111.259788 ER - TY - JOUR T1 - Evaluating a hybrid web-based basic genetics course for health professionals AN - 964269942; 201207597 AB - Health professionals, particularly nurses, continue to struggle with the expanding role of genetics information in the care of their patients. This paper describes an evaluation study of the effectiveness of a hybrid basic genetics course for healthcare professionals combining web-based learning with traditional face-to-face instructional techniques. A multidisciplinary group from the National Institutes of Health (NIH) created "Basic Genetics Education for Healthcare Providers" (BGEHCP). This program combined 7 web-based self-education modules with monthly traditional face-to-face lectures by genetics experts. The course was pilot tested by 186 healthcare providers from various disciplines with 69% (n=129) of the class registrants enrolling in a pre-post evaluation trial. Outcome measures included critical thinking knowledge items and a Web-based Learning Environment Inventory (WEBLEI). Results indicated a significant (p<0.001) change in knowledge scores. WEBLEI scores indicated program effectiveness particularly in the area of convenience, access and the course structure and design. Although significant increases in overall knowledge scores were achieved, scores in content areas surrounding genetic risk identification and ethical issues regarding genetic testing reflected continued gaps in knowledge. Web-based genetics education may help overcome genetics knowledge deficits by providing access for health professionals with diverse schedules in a variety of national and international settings. [Copyright Elsevier Ltd.] JF - Nurse Education Today AU - Wallen, Gwenyth R AU - Cusack, Georgie AU - Parada, Suzan AU - Miller-Davis, Claiborne AU - Cartledge, Tannia AU - Yates, Jan AD - National Institutes of Health, Clinical Center, Nursing Research and Translational Science, 10 Center Drive, Room 2B14, MSC-1151, Bethesda, MD 20892-1151, United States Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 638 EP - 642 PB - Elsevier Ltd, Amsterdam The Netherlands VL - 31 IS - 6 SN - 0260-6917, 0260-6917 KW - Genetics education WEBLEI Web-based nursing education KW - Professional knowledge KW - Health professionals KW - Health care KW - Computer based KW - Genetic screening KW - Internet KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964269942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nurse+Education+Today&rft.atitle=Evaluating+a+hybrid+web-based+basic+genetics+course+for+health+professionals&rft.au=Wallen%2C+Gwenyth+R%3BCusack%2C+Georgie%3BParada%2C+Suzan%3BMiller-Davis%2C+Claiborne%3BCartledge%2C+Tannia%3BYates%2C+Jan&rft.aulast=Wallen&rft.aufirst=Gwenyth&rft.date=2011-08-01&rft.volume=31&rft.issue=6&rft.spage=638&rft.isbn=&rft.btitle=&rft.title=Nurse+Education+Today&rft.issn=02606917&rft_id=info:doi/10.1016%2Fj.nedt.2010.11.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Computer based; Internet; Health professionals; Health care; Professional knowledge; Genetic screening DO - http://dx.doi.org/10.1016/j.nedt.2010.11.001 ER - TY - JOUR T1 - A partially linear regression model for data from an outcome-dependent sampling design AN - 940980625; 4280472 AB - The outcome-dependent sampling scheme has been gaining attention in both the statistical literature and applied fields. Epidemiological and environmental researchers have been using it to select the observations for more powerful and cost-effective studies. Motivated by a study of the effect of in utero exposure to poly-chlorinated biphenyls on children's intelligence quotient at age 7 years, in which the effect of an important confounding variable is non-linear, we consider a semiparametric regression model for data from an outcome-dependent sampling scheme where the relationship between the response and covariates is only partially parameterized. We propose a penalized spline maximum likelihood estimation for inference on both the parametric and the non-parametric components and develop their asymptotic properties. Through simulation studies and an analysis of the intelligence study, we compare the proposed estimator with several competing estimators. Practical considerations of implementing those estimators are discussed. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Longnecker, Matthew P AU - Zhou, Haibo AU - You, Jinhong AU - Qin, Guoyou AD - University of North Carolina, Chapel Hill ; National Institute of Environmental Health Sciences Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 559 EP - 574 VL - 60 IS - 4 SN - 0035-9254, 0035-9254 KW - Economics KW - Regression analysis KW - Simulation KW - Maximum likelihood method KW - Linear models KW - Sampling KW - Statistical methods KW - Data analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/940980625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=A+partially+linear+regression+model+for+data+from+an+outcome-dependent+sampling+design&rft.au=Longnecker%2C+Matthew+P%3BZhou%2C+Haibo%3BYou%2C+Jinhong%3BQin%2C+Guoyou&rft.aulast=Longnecker&rft.aufirst=Matthew&rft.date=2011-08-01&rft.volume=60&rft.issue=4&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=00359254&rft_id=info:doi/10.1111%2Fj.1467-9876.2010.00756.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 7419 8163; 10739 12228 10919; 3279 971 3286; 11255 12228 10919; 12228 10919; 7837 8160 8163 12230; 11670 DO - http://dx.doi.org/10.1111/j.1467-9876.2010.00756.x ER - TY - JOUR T1 - Intrathecal gene therapy for treatment of leptomeningeal carcinomatosis AN - 910647961; 15420327 AB - Leptomeningeal carcinomatosis occurs occasionally in patients with solid malignancies and carries a poor prognosis despite treatment with systemic chemotherapy and/or radiotherapy. We describe the case of a 43 year old man who presented with leptomeningeal carcinomatosis secondary to malignant melanoma. The patient received intraventricular delivery of NIH3T3 producer cells expressing the thymidine kinase (HSV-Tk1) gene via a retroviral vector followed by intravenous ganciclovir. He experienced abrupt and severe meningeal irritation and hyperpyrexia immediately after injection of the producer cells into the ventricular CSF. Vector producer cells (VPC) survived and were detected by NeoR marker gene expression in the CSF for a week, until a single dose of ganciclovir (GCV) was followed by a decline in the copy number of the NeoR marker gene to undetectable levels over 24 h. This decline upon introduction of ganciclovir suggests effective distribution of ganciclovir to producer cells bearing the HSV-Tk gene. The patient survived 9 months after treatment. Side-effects from the treatment included acute hyperpyrexia which was short-lived and medically manageable. JF - Journal of Neuro-Oncology AU - Heiss, John D AU - Taha, Sara AU - Oldfield, Edward H AU - Ram, Zvi AD - Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, 10-3D20, MSC-1414, Bethesda, MD, 20892-1414, USA, heissj@ninds.nih.gov Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 365 EP - 369 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 104 IS - 1 SN - 0167-594X, 0167-594X KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Cerebrospinal fluid KW - Chemotherapy KW - Expression vectors KW - Ganciclovir KW - Gene therapy KW - Intravenous administration KW - Irritation KW - Malignancy KW - Melanoma KW - Meninges KW - Oncology KW - Producer cells KW - Prognosis KW - Radiotherapy KW - Side effects KW - Thymidine kinase KW - copy number KW - G 07720:Immunogenetics KW - W 30905:Medical Applications KW - N3 11023:Neurogenetics KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/910647961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuro-Oncology&rft.atitle=Intrathecal+gene+therapy+for+treatment+of+leptomeningeal+carcinomatosis&rft.au=Heiss%2C+John+D%3BTaha%2C+Sara%3BOldfield%2C+Edward+H%3BRam%2C+Zvi&rft.aulast=Heiss&rft.aufirst=John&rft.date=2011-08-01&rft.volume=104&rft.issue=1&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuro-Oncology&rft.issn=0167594X&rft_id=info:doi/10.1007%2Fs11060-010-0458-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-12-03 N1 - SubjectsTermNotLitGenreText - Intravenous administration; Gene therapy; Chemotherapy; Producer cells; Prognosis; Radiotherapy; Oncology; Ganciclovir; Thymidine kinase; Irritation; Melanoma; copy number; Expression vectors; Meninges; Cerebrospinal fluid; Malignancy; Side effects DO - http://dx.doi.org/10.1007/s11060-010-0458-4 ER - TY - JOUR T1 - A stratified genetic risk assessment for testicular cancer AN - 907183814; 15726079 AB - Three genome-wide association studies of testicular cancer have uncovered predisposition alleles in or near KITLG, BAK1, SPRY4, TERT, ATF7IP and DMRT1. We investigated whether testicular cancer-risk alleles can be utilized in the clinical setting. We employed the receiver operating characteristic curves for genetic risk models to measure the discriminatory power of a risk variant-based risk model, and found that the newly discovered variants provided a discriminatory power of 69.2%. This suggested that about 69.2% of the time, a randomly selected patient with testicular cancer had a higher estimated risk than the risk for a randomly selected control subject. Using a multiplicative model, we estimated that white men in the top 1% of genetic risk as defined by eight risk variants had a relative risk that was 10.5-fold greater than that for the general white male population. This risk differential does not appear to be clinically useful, given the relative rarity and highly curable nature of testicular germ cell tumour (TGCT). In the authors' view, a stratified genetic risk assessment strategy might be useful, theoretically, for men who also have independent clinical risk factors for testicular cancer. Several established TGCT risk factors, such as cryptorchidism (RR=4.8) and male infertility (SIR=2.8) might prove useful in that context, but we currently do not know whether these testicular cancer-risk loci are associated with, or independent of, such clinical risk factors. More research is required before we can utilize testicular cancer-risk loci for clinically meaningful risk prediction. JF - International Journal of Andrology AU - Kratz, C P AU - Greene, M H AU - Bratslavsky, G AU - Shi, J AD - Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - e98 EP - e102 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 34 IS - 4pt2 SN - 0105-6263, 0105-6263 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Cancer KW - Prediction KW - Risk assessment KW - Risk factors KW - infertility KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907183814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Andrology&rft.atitle=A+stratified+genetic+risk+assessment+for+testicular+cancer&rft.au=Kratz%2C+C+P%3BGreene%2C+M+H%3BBratslavsky%2C+G%3BShi%2C+J&rft.aulast=Kratz&rft.aufirst=C&rft.date=2011-08-01&rft.volume=34&rft.issue=4pt2&rft.spage=e98&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Andrology&rft.issn=01056263&rft_id=info:doi/10.1111%2Fj.1365-2605.2011.01156.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Document feature - figure 2 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Prediction; Risk assessment; infertility; Risk factors; Cancer DO - http://dx.doi.org/10.1111/j.1365-2605.2011.01156.x ER - TY - JOUR T1 - Personal exposure to PM2.5 among high-school students in Milan and background measurements: The EuroLifeNet study AN - 904487639; 15167575 AB - As part of the EuroLifeNet program we measured personal exposure to PM2.5 in 90 pupils attending three schools in Milan, over a three-week period spanning November and December 2006, using a portable light-scattering nephelometer. The primary aim was to investigate the relationship between personal exposure to PM2.5 and background measurements obtained from a fixed monitoring station. Pearson's correlation coefficient between sampled daily mean exposures and reference values from background station varied from 0.64 to 0.75, with an overall value of 0.63, indicating good agreement. We also estimated that about 40% of the variability in the mean daily personal exposure at the three schools was due to variability in background exposure, the remaining 60% due to between-subject differences in exposures or to other sources of error. JF - Atmospheric Environment AU - Borgini, A AU - Tittarelli, A AU - Ricci, C AU - Bertoldi, M AU - De Saeger, E AU - Crosignani, P AD - Cancer Registry and Environmental Epidemiology Unit, National Cancer Institute, Via Venezian 1, 20133 Milano, Italy, alessandro.borgini@istitutotumori.mi.it Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 4147 EP - 4151 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 45 IS - 25 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Environment Abstracts; Meteorological & Geoastrophysical Abstracts KW - Particle size KW - Particulate matter in atmosphere KW - Atmospheric pollution KW - schools KW - nephelometers KW - Correlations KW - Nephelometers KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904487639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Personal+exposure+to+PM2.5+among+high-school+students+in+Milan+and+background+measurements%3A+The+EuroLifeNet+study&rft.au=Borgini%2C+A%3BTittarelli%2C+A%3BRicci%2C+C%3BBertoldi%2C+M%3BDe+Saeger%2C+E%3BCrosignani%2C+P&rft.aulast=Borgini&rft.aufirst=A&rft.date=2011-08-01&rft.volume=45&rft.issue=25&rft.spage=4147&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2011.05.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Number of references - 1 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Particulate matter in atmosphere; Atmospheric pollution; Nephelometers; Correlations; Particle size; nephelometers; schools DO - http://dx.doi.org/10.1016/j.atmosenv.2011.05.026 ER - TY - JOUR T1 - Reproducible High Yields of Recombinant Adeno-Associated Virus Produced Using Invertebrate Cells in 0.02- to 200-Liter Cultures AN - 902367717; 15742354 AB - The large amounts of recombinant adeno-associated virus (rAAV) vector needed for clinical trials and eventual commercialization require robust, economical, reproducible, and scalable production processes compatible with current good manufacturing practice. rAAV produced using baculovirus and insect cells satisfies these conditions; however, recovering rAAV particles from 200-liter bioreactors is more complicated than bench-scale vector preparations. Using a variety of processing media, we developed a reliable and routine downstream procedure for rAAV production that is scalable from 0.02- to 200-liter cultures. To facilitate the upstream process, we adapted the titerless infected-cell preservation and scale-up process for rAAV production. Single-use aliquots of cryopreserved baculovirus-infected insect cells (BIIC) are thawed and added to the suspension culture to achieve the desired ratio of BIIC to rAAV-producer cells. By using conditions established with small-scale cultures, rAAV was produced in larger volume cultures. Strikingly consistent rAAV yields were attained in cultures ranging from 10 liters to 200 liters. Based on the final yield, each cell produced 18,000 plus or minus 6,800 particles of purified rAAV in 10-, 20-, 100-, and 200-liter cultures. Thus, with an average cell density of 4.32x10 super(6) cells/ml, greater than or equal to 10 super(16) purified rAAV particles are produced from 100 to 200 liters. The downstream process resulted in about 20% recovery estimated from comparing the quantities of capsid protein antigen in the crude bioreactor material and in the final, purified product. The ease and reproducibility of rAAV production in 200-liter bioreactors suggest that the limit has not been reached, and 500-liter productions are planned. JF - Human Gene Therapy AU - Cecchini, S AU - Virag, T AU - Kotin, R M AD - Laboratory of Molecular Virology and Gene Therapy, Building 10, Room 7D05, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA, kotinr@nhlbi.nih.gov Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 1021 EP - 1030 VL - 22 IS - 8 SN - 1043-0342, 1043-0342 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene therapy KW - Cell density KW - Cell culture KW - Suspension culture KW - Clinical trials KW - Cryopreservation KW - Adeno-associated virus KW - Bioreactors KW - Insect cells KW - Invertebrata KW - Preservation KW - Baculovirus KW - Media (culture) KW - Capsid protein KW - W 30905:Medical Applications KW - G 07880:Human Genetics KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902367717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Reproducible+High+Yields+of+Recombinant+Adeno-Associated+Virus+Produced+Using+Invertebrate+Cells+in+0.02-+to+200-Liter+Cultures&rft.au=Cecchini%2C+S%3BVirag%2C+T%3BKotin%2C+R+M&rft.aulast=Cecchini&rft.aufirst=S&rft.date=2011-08-01&rft.volume=22&rft.issue=8&rft.spage=1021&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2010.250 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Gene therapy; Insect cells; Bioreactors; Cell density; Suspension culture; Cell culture; Preservation; Cryopreservation; Clinical trials; Media (culture); Capsid protein; Invertebrata; Baculovirus; Adeno-associated virus DO - http://dx.doi.org/10.1089/hum.2010.250 ER - TY - JOUR T1 - Association between inhibited binding of folic acid to folate receptor alpha in maternal serum and folate-related birth defects in Norway AN - 899170768; 15601895 AB - BACKGROUND Folic acid intake during pregnancy can reduce the risk of neural tube defects (NTDs) and perhaps also oral facial clefts. Maternal autoantibodies to folate receptors can impair folic acid binding. We explored the relationship of these birth defects to inhibition of folic acid binding to folate receptor alpha (FR alpha ), as well as possible effects of parental demographics or prenatal exposures. METHODS We conducted a nested case-control study within the Norwegian Mother and Child Cohort Study. The study included mothers of children with an NTD (n= 11), cleft lip with or without cleft palate (CL/P, n= 72), or cleft palate only (CPO, n= 27), and randomly selected mothers of controls (n= 221). The inhibition of folic acid binding to FR alpha was measured in maternal plasma collected around 17 weeks of gestation. On the basis of prior literature, the maternal age, gravidity, education, smoking, periconception folic acid supplement use and milk consumption were considered as potential confounding factors. RESULTS There was an increased risk of NTDs with increased binding inhibition [adjusted odds ratio (aOR) = 1.4, 95% confidence interval (CI) 1.0-1.8]. There was no increased risk of oral facial clefts from inhibited folic acid binding to FR alpha (CL/P aOR = 0.7, 95% CI 0.6-1.0; CPO aOR = 1.1, 95% CI 0.8-1.4). No association was seen between smoking, folate supplementation or other cofactors and inhibition of folic acid binding to FR alpha . CONCLUSIONS Inhibition of folic acid binding to FR alpha in maternal plasma collected during pregnancy was associated with increased risk of NTDs but not oral facial clefts. JF - Human Reproduction AU - Boyles, AL AU - Ballard, J L AU - Gorman, E B AU - McConnaughey AU - Cabrera, R M AU - Wilcox, A J AU - Lie, R T AU - Finnell, R H AD - 2 Texas A&M Institute for Genomic Medicine, College Station, TX 77843, USA, boylesa@niehs.nih.gov Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 2232 EP - 2238 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 26 IS - 8 SN - 0268-1161, 0268-1161 KW - Risk Abstracts KW - demography KW - Milk KW - Pregnancy KW - folic acid KW - Smoking KW - risk reduction KW - Education KW - Congenital defects KW - Reproduction KW - Norway KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899170768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Reproduction&rft.atitle=Association+between+inhibited+binding+of+folic+acid+to+folate+receptor+alpha+in+maternal+serum+and+folate-related+birth+defects+in+Norway&rft.au=Boyles%2C+AL%3BBallard%2C+J+L%3BGorman%2C+E+B%3BMcConnaughey%3BCabrera%2C+R+M%3BWilcox%2C+A+J%3BLie%2C+R+T%3BFinnell%2C+R+H&rft.aulast=Boyles&rft.aufirst=AL&rft.date=2011-08-01&rft.volume=26&rft.issue=8&rft.spage=2232&rft.isbn=&rft.btitle=&rft.title=Human+Reproduction&rft.issn=02681161&rft_id=info:doi/10.1093%2Fhumrep%2Fder144 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - demography; folic acid; risk reduction; Smoking; Education; Milk; Congenital defects; Reproduction; Pregnancy; Norway DO - http://dx.doi.org/10.1093/humrep/der144 ER - TY - JOUR T1 - Associations of Medically Documented Psychiatric Diagnoses and Risky Health Behaviors in Highly Active Antiretroviral Therapy-Experienced Perinatally HIV-Infected Youth AN - 893272011; 15630677 AB - The Longitudinal Epidemiologic Study to Gain Insight into HIV/AIDS in Children and Youth (LEGACY) study is a prospective, multisite, longitudinal cohort of U.S. HIV-infected youth. This analysis was limited to perinatally HIV-infected youth (n=197), 13 years and older, with selected variables completely abstracted from HIV diagnosis through 2006. We evaluated relationships between ever having one or more nonsubstance related medically documented psychiatric diagnoses and three risky health behaviors (substance abuse, preadult sexual activity, and treatment adherence problems) recorded between 2001 and 2006. Logistic regression was used for all binary outcomes and participant age was included as a covariate when possible. All 197 participants included in the analysis were prescribed antiretroviral therapy during the study period; 110 (56%) were female, 100 (51%) were black non-Hispanic, and 86 (44%) were Hispanic; mean age at the last visit was 16.8 years, ranging from 13 to 24 years. One hundred forty-six (74%) participants had a history of at least one risky health behavior. There were 108 (55%) participants with at least one medically documented psychiatric diagnosis, 17 (9%) with at least one record of substance abuse, 12 (6%) with documented preadult sexual activity, and 142 (72%) participants with reported adherence problems. In the final model, a history of at least one psychiatric diagnosis was associated with having at least one of the three risky behaviors (odds ratio [OR]=2.33, p=0.015). There is a need for a continued close partnership between HIV specialty care providers and mental health services treating perinatally HIV-infected youth with an added focus on improving treatment adherence. JF - AIDS Patient Care and STDs AU - Kapetanovic, S AU - Wiegand, R E AU - Dominguez, K AU - Blumberg, D AU - Bohannon, B AU - Wheeling, J AU - Rutstein, R AD - National Institutes of Health, National Institute of Mental Health, Office of the Clinical Director, Building 10-CRC, Room 6-5340, 10 Center Drive, Bethesda, MD 20892-1276, USA, suad.kapetanovic@nih.gov Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 493 EP - 501 VL - 25 IS - 8 SN - 1087-2914, 1087-2914 KW - Health & Safety Science Abstracts; Risk Abstracts; Virology & AIDS Abstracts KW - Historical account KW - Age KW - Acquired immune deficiency syndrome KW - antiretroviral therapy KW - Drug abuse KW - Children KW - Models KW - substance abuse KW - USA KW - Mental disorders KW - Behavior KW - Antiviral agents KW - Human immunodeficiency virus KW - antiretroviral agents KW - sexually transmitted diseases KW - Ethnic groups KW - Substance abuse KW - Sexually transmitted diseases KW - V 22360:AIDS and HIV KW - H 4000:Food and Drugs KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893272011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Patient+Care+and+STDs&rft.atitle=Associations+of+Medically+Documented+Psychiatric+Diagnoses+and+Risky+Health+Behaviors+in+Highly+Active+Antiretroviral+Therapy-Experienced+Perinatally+HIV-Infected+Youth&rft.au=Kapetanovic%2C+S%3BWiegand%2C+R+E%3BDominguez%2C+K%3BBlumberg%2C+D%3BBohannon%2C+B%3BWheeling%2C+J%3BRutstein%2C+R&rft.aulast=Kapetanovic&rft.aufirst=S&rft.date=2011-08-01&rft.volume=25&rft.issue=8&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=AIDS+Patient+Care+and+STDs&rft.issn=10872914&rft_id=info:doi/10.1089%2Fapc.2011.0107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Mental disorders; Age; Antiviral agents; antiretroviral therapy; Children; Drug abuse; Models; substance abuse; Historical account; Behavior; Human immunodeficiency virus; antiretroviral agents; Sexually transmitted diseases; Substance abuse; Ethnic groups; sexually transmitted diseases; USA DO - http://dx.doi.org/10.1089/apc.2011.0107 ER - TY - JOUR T1 - Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits. AN - 893264300; 21626413 AB - In the last decade, a growing scientific and medical interest has emerged toward cardiovascular effects of dietary nitrite and nitrate; however, many questions concerning their mode of action(s) remain unanswered. In this review, we focus on multiple mechanisms that might account for potential cardiovascular beneficial effects of dietary nitrite and nitrate. Beneficial changes to cardiovascular health from dietary nitrite and nitrate might result from several mechanism(s) including their reduction into nitric oxide, improvement in endothelial function, vascular relaxation, and/or inhibition of the platelet aggregation. From recently obtained evidence, it appears that the longstanding concerns about the toxicity of oral nitrite or nitrate are overstated. Dietary nitrite and nitrate may have cardiovascular protective effects in both healthy individuals and also those with cardiovascular disease conditions. A role for nitrite and nitrate in nitric oxide biosynthesis and/or in improving nitric oxide bioavailability may eventually provide a rationale for using dietary nitrite and nitrate supplementation in the treatment and prevention of cardiovascular diseases. JF - European journal of nutrition AU - Machha, Ajay AU - Schechter, Alan N AD - Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 293 EP - 303 VL - 50 IS - 5 KW - Nitrates KW - 0 KW - Nitrites KW - Platelet Aggregation Inhibitors KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Animals KW - Endothelium -- metabolism KW - Humans KW - Dietary Supplements KW - Biological Availability KW - Nitric Oxide -- pharmacokinetics KW - Cardiovascular Diseases -- drug therapy KW - Nitric Oxide -- biosynthesis KW - Nitrates -- pharmacokinetics KW - Diet KW - Nitrites -- pharmacokinetics KW - Cardiovascular Diseases -- prevention & control KW - Platelet Aggregation Inhibitors -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893264300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+nutrition&rft.atitle=Dietary+nitrite+and+nitrate%3A+a+review+of+potential+mechanisms+of+cardiovascular+benefits.&rft.au=Machha%2C+Ajay%3BSchechter%2C+Alan+N&rft.aulast=Machha&rft.aufirst=Ajay&rft.date=2011-08-01&rft.volume=50&rft.issue=5&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=European+journal+of+nutrition&rft.issn=1436-6215&rft_id=info:doi/10.1007%2Fs00394-011-0192-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-19 N1 - Date created - 2011-08-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Free Radic Biol Med. 2008 Aug 15;45(4):468-74 [18501719] Nitric Oxide. 2008 Dec;19(4):333-7 [18793740] J Biol Chem. 2008 Dec 5;283(49):33927-34 [18835812] Basic Res Cardiol. 2009 Mar;104(2):113-9 [19242636] Front Biosci (Landmark Ed). 2009;14:4793-808 [19273390] Arch Intern Med. 2009 Apr 13;169(7):659-69 [19364995] Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1281-8 [19252084] Free Radic Biol Med. 2009 Apr 15;46(8):1068-75 [19439233] Kidney Int. 2009 Jun;75(11):1140-4 [19212422] Hypertension. 2009 Aug;54(2):322-8 [19581509] Med Res Rev. 2009 Sep;29(5):683-741 [19219851] Br J Pharmacol. 2009 Aug;157(8):1523-30 [19594749] Nat Rev Cardiol. 2009 Sep;6(9):599-608 [19652655] Atherosclerosis. 2009 Sep;206(1):61-8 [19268941] Arch Pharm Res. 2009 Aug;32(8):1119-26 [19727604] Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2068-74 [19820197] J Biol Chem. 2009 Dec 4;284(49):33850-8 [19801639] Nitric Oxide. 2010 Feb 15;22(2):136-40 [19887114] Int Heart J. 2010 Jan;51(1):1-6 [20145343] Cancer Res. 2010 Mar 15;70(6):2406-14 [20215514] Hypertension. 2010 Aug;56(2):274-81 [20585108] Cancer. 2010 Sep 15;116(18):4345-53 [20681011] Am J Cardiovasc Drugs. 2010;10(5):315-20 [20860414] Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17716-20 [20876122] Heart. 2010 Nov;96(21):1703-9 [20736204] Methods Mol Biol. 2011;704:39-56 [21161628] Curr Opin Lipidol. 2011 Feb;22(1):11-5 [21102328] Br J Nutr. 1999 May;81(5):349-58 [10615207] Public Health Nutr. 2000 Mar;3(1):103-7 [10786730] Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11482-7 [11027349] Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):355-60 [11134509] Nitric Oxide. 2002 Aug;7(1):24-9 [12175816] Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):336-41 [12502793] Natl Toxicol Program Tech Rep Ser. 2001 May;495:7-273 [12563346] Free Radic Biol Med. 2003 Mar 1;34(5):576-84 [12614846] J Clin Invest. 2003 Apr;111(8):1201-9 [12697739] J Agric Food Chem. 2003 Sep 24;51(20):6014-20 [13129310] Curr Atheroscler Rep. 2003 Nov;5(6):492-9 [14525683] Free Radic Biol Med. 2003 Oct 1;35(7):790-6 [14583343] Nat Med. 2003 Dec;9(12):1498-505 [14595407] Free Radic Biol Med. 2004 Feb 15;36(4):413-22 [14975444] Clin Sci (Lond). 2004 May;106(5):443-5 [14741042] Blood Cells Mol Dis. 2004 May-Jun;32(3):423-9 [15121102] Free Radic Biol Med. 2004 Aug 1;37(3):395-400 [15223073] Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13683-8 [15347817] Nat Med. 2004 Oct;10(10):1122-7 [15361865] Food Cosmet Toxicol. 1976 Dec;14(6):545-8 [1017769] Food Cosmet Toxicol. 1976 Dec;14(6):549-52 [1017770] Proc Natl Acad Sci U S A. 1977 Aug;74(8):3203-7 [20623] Can J Physiol Pharmacol. 1981 Feb;59(2):150-6 [6112057] Food Chem Toxicol. 1984 Oct;22(10):789-95 [6541617] J Pharmacol Exp Ther. 1990 Jan;252(1):35-41 [2153807] Clin Biochem. 1990 Feb;23(1):67-71 [2184959] Int J Epidemiol. 1990 Sep;19(3):510-5 [2262241] Pharmacol Toxicol. 1991 Jan;68(1):60-3 [1848931] Pharmacol Rev. 1991 Jun;43(2):109-42 [1852778] Circ Res. 1993 Feb;72(2):403-12 [8418991] Nature. 1994 Apr 7;368(6471):502 [8139683] Gut. 1994 Nov;35(11):1543-6 [7828969] Biochem Biophys Res Commun. 1995 Apr 17;209(2):590-6 [7794389] Br J Clin Pharmacol. 1995 Apr;39(4):460-2 [7640157] Nat Med. 1995 Jun;1(6):546-51 [7585121] Nat Med. 1995 Aug;1(8):804-9 [7585184] Am J Surg. 1996 Aug;172(2):158-61; discussion 161-2 [8795521] Int J Epidemiol. 1997 Feb;26(1):1-13 [9126498] Circ Res. 1998 Feb 9;82(2):186-94 [9468189] Blood. 1998 May 15;91(10):3527-61 [9572988] Nutr Rev. 1998 Apr;56(4 Pt 1):95-105 [9584494] FEBS Lett. 1998 May 8;427(2):225-8 [9607316] Am J Med. 1998 Jul 6;105(1A):32S-39S [9707266] Cardiovasc Res. 1999 Mar;41(3):765-72 [10435049] Biochem Biophys Res Commun. 1999 Oct 5;263(3):681-4 [10512739] Mol Aspects Med. 2005 Feb-Apr;26(1-2):33-65 [15722114] Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2163-70 [15626692] Free Radic Biol Med. 2005 May 15;38(10):1278-95 [15855047] J Clin Invest. 2005 May;115(5):1232-40 [15841216] Blood. 2005 Jul 15;106(2):734-9 [15774613] Comp Biochem Physiol A Mol Integr Physiol. 2005 Oct;142(2):130-5 [15936233] Biochem Biophys Res Commun. 2006 Mar 17;341(3):816-21 [16442076] Expert Opin Emerg Drugs. 2006 Mar;11(1):49-73 [16503826] Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):697-705 [16424350] Cell Metab. 2006 Apr;3(4):277-87 [16581005] Clin Exp Pharmacol Physiol. 2006 Apr;33(4):345-50 [16620299] J Biol Chem. 2006 May 5;281(18):12546-54 [16527817] Nat Chem Biol. 2006 Sep;2(9):486-93 [16906150] Curr Atheroscler Rep. 2006 Nov;8(6):460-5 [17045071] Stroke. 2006 Nov;37(11):2744-50 [17008610] N Engl J Med. 2006 Dec 28;355(26):2792-3 [17192551] Cell Mol Life Sci. 2007 Jan;64(1):96-103 [17160351] Vasc Health Risk Manag. 2005;1(3):183-98 [17319104] Circ Res. 2007 Mar 2;100(4):460-73 [17332437] Circ Res. 2007 Mar 16;100(5):654-61 [17293481] Cardiovasc Res. 2007 Jul 15;75(2):327-38 [17568573] J Exp Med. 2007 Sep 3;204(9):2089-102 [17682069] J Mol Cell Cardiol. 2007 Oct;43(4):437-44 [17765919] Circulation. 2007 Oct 16;116(16):1821-31 [17893272] Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):19144-9 [18025468] Nat Rev Drug Discov. 2008 Feb;7(2):156-67 [18167491] Hypertension. 2008 Mar;51(3):784-90 [18250365] Biochemistry. 2008 Mar 4;47(9):2989-96 [18225862] Proc Natl Acad Sci U S A. 2008 May 27;105(21):7540-5 [18508974] Circulation. 2008 Jun 10;117(23):2986-94 [18519850] Nat Chem Biol. 2008 Jul;4(7):411-7 [18516050] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00394-011-0192-5 ER - TY - JOUR T1 - Vitamin D status and metabolic syndrome in Asian Indians AN - 888113489; 15465823 AB - In this study, we aimed to estimate serum 25-hydroxy vitamin D (25-OH-D) in Asian Indians and test for association between 25-OH-D levels, insulin resistance (IR) and metabolic syndrome (MS). Serum 25-OH-D was measured in a cross-sectional sample of 441 Indians, aged 39.7+/-12.8 years (237 men and 204 women) with 27.9% prevalence of MS. Vitamin D insufficiency (12.5 to 0.05). Although highly prevalent, vitamin D insufficient status was not associated with MS or IR in Asian Indians of either sex. JF - International Journal of Obesity AU - Majumdar, V AU - Nagaraja, D AU - Christopher, R AD - Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore, India Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 1131 EP - 1134 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 35 IS - 8 SN - 0307-0565, 0307-0565 KW - Health & Safety Science Abstracts KW - metabolic disorders KW - vitamins KW - insulin KW - obesity KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888113489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Obesity&rft.atitle=Vitamin+D+status+and+metabolic+syndrome+in+Asian+Indians&rft.au=Majumdar%2C+V%3BNagaraja%2C+D%3BChristopher%2C+R&rft.aulast=Majumdar&rft.aufirst=V&rft.date=2011-08-01&rft.volume=35&rft.issue=8&rft.spage=1131&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Obesity&rft.issn=03070565&rft_id=info:doi/10.1038%2Fijo.2010.232 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2014-10-30 N1 - SubjectsTermNotLitGenreText - metabolic disorders; vitamins; insulin; obesity DO - http://dx.doi.org/10.1038/ijo.2010.232 ER - TY - JOUR T1 - HIV type 1 Env precursor cleavage state affects recognition by both neutralizing and nonneutralizing gp41 antibodies. AN - 886912551; 21158699 AB - HIV-1 is relatively resistant to antibody-mediated neutralization; however, rare antibodies to the exterior envelope glycoprotein, gp120, and the transmembrane glycoprotein, gp41, can neutralize a broad array of isolates. Two antibodies, 2F5 and 4E10, are directed against the gp41 membrane proximal external region (MPER); however, the kinetic neutralization signature of these antibodies remains unresolved. Previously, we reported that the fully cleaved, cell surface envelope glycoproteins (Env) derived from the primary isolate, JR-FL, are well recognized exclusively by gp120-directed neutralizing ligands and not by nonneutralizing gp120 antibodies. However, the gp120 nonneutralizing antibodies can recognize HIV spikes that are rendered fully cleavage defective by site-directed mutagenesis. Here, we extended such analysis to gp41 neutralizing and nonneutralizing antibodies and, relative to the rules of gp120-specific antibody recognition, we observed marked contrasts. Similar to gp120 recognition, the nonneutralizing gp41 cluster 1 or cluster 2 antibodies bound much more efficiently to cleavage-defective spikes when compared to their recognition of cleaved spikes. In contrast to gp120 neutralizing antibody recognition, the broadly neutralizing gp41 antibodies 2F5 and 4E10, like the nonneutralizing gp41 antibodies, did not efficiently recognize the predominantly cleaved, primary isolate JR-FL spikes. However, if the spikes were rendered cleavage defective, recognition by both the neutralizing and nonneutralizing ligand markedly increased. CD4 interaction with the cleaved spikes markedly increased recognition by most nonneutralizing gp41 antibodies, whereas such treatment had a minimal increase of 2F5 and 4E10 recognition. These data indicate again the profound influence that cleavage imposes on the quaternary packing of primary isolate spikes and have important implications for soluble trimer candidate immunogens. JF - AIDS research and human retroviruses AU - Chakrabarti, Bimal K AU - Pancera, Marie AU - Phogat, Sanjay AU - O'Dell, Sijy AU - McKee, Krisha AU - Guenaga, Javier AU - Robinson, James AU - Mascola, John AU - Wyatt, Richard T AD - Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 877 EP - 887 VL - 27 IS - 8 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Neutralizing KW - Antigens, CD4 KW - HIV Antibodies KW - HIV Envelope Protein gp120 KW - HIV Envelope Protein gp41 KW - Peptide Fragments KW - Protein Precursors KW - gp41 protein, Human immunodeficiency virus 1 KW - Index Medicus KW - AIDS/HIV KW - Peptide Fragments -- metabolism KW - Animals KW - Solubility KW - Humans KW - Mice KW - Plasmids KW - Peptide Fragments -- immunology KW - Protein Binding KW - NIH 3T3 Cells KW - Blotting, Western KW - Peptide Fragments -- chemistry KW - Transfection KW - Neutralization Tests KW - Flow Cytometry KW - Protein Structure, Tertiary KW - HIV-1 -- immunology KW - HIV Infections -- virology KW - Antibodies, Monoclonal -- pharmacology KW - Antigens, CD4 -- immunology KW - Antigens, CD4 -- metabolism KW - Antibodies, Monoclonal -- immunology KW - HIV-1 -- metabolism KW - Protein Precursors -- immunology KW - HIV Envelope Protein gp120 -- immunology KW - HIV Antibodies -- metabolism KW - HIV Infections -- immunology KW - Antibodies, Neutralizing -- immunology KW - Protein Precursors -- metabolism KW - Antibodies, Monoclonal -- metabolism KW - HIV Envelope Protein gp120 -- chemistry KW - HIV Envelope Protein gp41 -- metabolism KW - HIV Envelope Protein gp41 -- immunology KW - HIV Envelope Protein gp120 -- metabolism KW - HIV Antibodies -- immunology KW - Protein Precursors -- chemistry KW - HIV Infections -- metabolism KW - HIV-1 -- drug effects KW - HIV Antibodies -- pharmacology KW - Antibodies, Neutralizing -- pharmacology KW - Antibodies, Neutralizing -- metabolism KW - HIV Envelope Protein gp41 -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/886912551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+research+and+human+retroviruses&rft.atitle=HIV+type+1+Env+precursor+cleavage+state+affects+recognition+by+both+neutralizing+and+nonneutralizing+gp41+antibodies.&rft.au=Chakrabarti%2C+Bimal+K%3BPancera%2C+Marie%3BPhogat%2C+Sanjay%3BO%27Dell%2C+Sijy%3BMcKee%2C+Krisha%3BGuenaga%2C+Javier%3BRobinson%2C+James%3BMascola%2C+John%3BWyatt%2C+Richard+T&rft.aulast=Chakrabarti&rft.aufirst=Bimal&rft.date=2011-08-01&rft.volume=27&rft.issue=8&rft.spage=877&rft.isbn=&rft.btitle=&rft.title=AIDS+research+and+human+retroviruses&rft.issn=1931-8405&rft_id=info:doi/10.1089%2FAID.2010.0281 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-28 N1 - Date created - 2011-08-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: AIDS. 1997;11 Suppl A:S87-98 [9451972] Nature. 1998 Feb 12;391(6668):638-9 [9490406] Science. 1998 Mar 27;279(5359):2103-6 [9516110] J Virol. 1998 Jun;72(6):4694-703 [9573233] J Virol. 1998 Dec;72(12):10270-4 [9811774] Eur Cytokine Netw. 1998 Sep;9(3 Suppl):5-11 [9831179] J Virol. 1999 Feb;73(2):1350-61 [9882340] J Virol. 2010 Feb;84(3):1302-13 [19906907] PLoS One. 2010;5(1):e8805 [20098712] Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5972-7 [20231447] Science. 2010 Aug 13;329(5993):856-61 [20616233] J Virol. 2000 Jul;74(13):6186-92 [10846104] J Virol. 2001 Feb;75(3):1165-71 [11152489] AIDS Res Hum Retroviruses. 2000 Dec 10;16(18):2019-35 [11153085] J Virol. 2001 May;75(9):4208-18 [11287570] J Virol. 2001 Jun;75(12):5526-40 [11356960] J Biol Chem. 2001 Oct 26;276(43):39577-85 [11514580] J Virol. 2002 Mar;76(6):2606-16 [11861826] J Virol. 2002 Mar;76(6):2835-47 [11861851] J Virol. 2002 Apr;76(7):3511-21 [11884575] J Virol. 2002 May;76(9):4634-42 [11932429] J Virol. 2002 Jun;76(11):5357-68 [11991964] J Virol. 2002 Aug;76(15):7760-76 [12097589] J Virol. 2002 Aug;76(15):7863-7 [12097599] J Virol. 2002 Sep;76(17):8875-89 [12163607] AIDS Res Hum Retroviruses. 2003 Mar;19(3):217-26 [12689414] J Virol. 2003 May;77(10):5678-84 [12719560] J Virol. 2000 Jan;74(2):627-43 [10623724] Cell. 1999 Oct 1;99(1):103-15 [10520998] Virology. 2005 Feb 5;332(1):145-56 [15661147] Virology. 2005 Jul 20;338(1):154-72 [15932765] Expert Rev Vaccines. 2006 Aug;5(4):579-95 [16989638] J Virol. 2006 Dec;80(23):11776-90 [16971434] Nat Med. 2007 Sep;13(9):1032-4 [17721546] J Virol. 2008 Mar;82(5):2367-75 [18094155] Virology. 2008 Aug 1;377(2):364-78 [18539308] J Virol. 2008 Dec;82(24):12449-63 [18842730] J Virol. 2009 Jan;83(2):757-69 [18987148] Virology. 2009 Mar 1;385(1):275-81 [19135223] PLoS Pathog. 2009 May;5(5):e1000433 [19436712] PLoS Pathog. 2009 May;5(5):e1000445 [19478876] Nat Med. 2009 Aug;15(8):951-4 [19525965] Science. 2009 Oct 9;326(5950):285-9 [19729618] Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20234-9 [19906992] Virology. 2003 Sep 1;313(2):387-400 [12954207] Nat Immunol. 2004 Mar;5(3):233-6 [14985706] J Virol. 2004 May;78(9):4710-9 [15078953] Vaccine. 2004 Feb 25;22(8):1032-46 [15161081] Nature. 1984 Dec 20-1985 Jan 2;312(5996):763-7 [6096719] Proc Natl Acad Sci U S A. 1986 Sep;83(18):7023-7 [3018753] J Clin Microbiol. 1988 Feb;26(2):231-5 [3422647] Proc Natl Acad Sci U S A. 1988 Dec;85(24):9580-4 [2849111] Proc Natl Acad Sci U S A. 1990 Sep;87(17):6574-8 [2395859] J Exp Med. 1991 Aug 1;174(2):407-15 [1713252] J Virol. 1992 May;66(5):3125-30 [1373203] Science. 1992 Jul 24;257(5069):535-7 [1636088] J Virol. 1992 Sep;66(9):5516-24 [1501286] Nature. 1992 Nov 26;360(6402):358-61 [1360148] J Virol. 1993 Mar;67(3):1461-71 [8437224] J Virol. 1993 Nov;67(11):6642-7 [7692082] J Virol. 1994 Apr;68(4):2253-9 [8139010] Virology. 1995 Jan 10;206(1):713-7 [7530400] Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):1921-5 [7892200] J Virol. 1995 Jul;69(7):4413-22 [7769703] J Virol. 1995 Sep;69(9):5217-27 [7636963] Cell. 1996 Jun 28;85(7):1135-48 [8674119] Nature. 1996 Nov 14;384(6605):179-83 [8906795] Cell. 1997 Apr 18;89(2):263-73 [9108481] J Virol. 1997 Jun;71(6):4319-30 [9151820] Nature. 1997 May 22;387(6631):426-30 [9163431] N Engl J Med. 1997 Oct 30;337(18):1267-74 [9345075] Virology. 1997 Nov 24;238(2):254-64 [9400598] J Virol. 1998 Feb;72(2):1497-503 [9445053] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/AID.2010.0281 ER - TY - JOUR T1 - Minimal detection bias in the inverse association between statin drug use and advanced prostate cancer risk: A simulation study AN - 885050307; 15380066 AB - Background: Prospective studies support that statins may protect against advanced prostate cancer. Detection bias arising from higher PSA screening rates among statin users vs. non-users could produce an inverse association for advanced disease. Thus, we conducted simulations to assess whether this source of bias is explanatory. Methods: 3000 datasets with 100,000 men without prostate cancer were simulated for populations with high (65%) or low (15%) PSA screening. We investigated three scenarios: RRtrue=1.0, 0.75, and 0.5 for statins and advanced disease (1.0 for localized). We set the statin prevalence to 10% and varied the percentage of users who were PSA screened (0-100%). We assumed an annual total prostate cancer incidence of 1%, with risk in screened men twice that of unscreened men, and an advanced stage at diagnosis in 20% and 40% of cases in screened and unscreened men, respectively. Results: As PSA screening and statin use became more coincident, the RRobservedfor local and total prostate cancer was biased upward from the RRtrueof 1.0, especially when the prevalence of PSA screening was low. However, in all simulated scenarios, there was little downward bias for advanced disease (e.g., if RRtrue=1.0 and 70% of statin users and either 65% or 15% of the population overall was PSA screened, then RRobserved=0.98 for both). Conclusions: Given our assumptions, this simulation suggests that this source of detection bias is unlikely to explain the reported inverse association between statins and advanced prostate cancer, but may explain the positive association for total prostate cancer that has been reported in some studies. JF - Cancer Epidemiology AU - Mondul, Alison M AU - Caffo, Brian AU - Platz, Elizabeth A Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - e6 EP - e11 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 35 IS - 4 SN - 1877-7821, 1877-7821 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Cancer KW - Drug abuse KW - Simulation KW - prostate cancer KW - statins KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885050307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology&rft.atitle=Minimal+detection+bias+in+the+inverse+association+between+statin+drug+use+and+advanced+prostate+cancer+risk%3A+A+simulation+study&rft.au=Mondul%2C+Alison+M%3BCaffo%2C+Brian%3BPlatz%2C+Elizabeth+A&rft.aulast=Mondul&rft.aufirst=Alison&rft.date=2011-08-01&rft.volume=35&rft.issue=4&rft.spage=e6&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology&rft.issn=18777821&rft_id=info:doi/10.1016%2Fj.canep.2010.11.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Simulation; statins; Drug abuse; prostate cancer; Cancer DO - http://dx.doi.org/10.1016/j.canep.2010.11.005 ER - TY - JOUR T1 - Succinic acid production from sugarcane bagasse hemicellulose hydrolysate by Actinobacillus succinogenes AN - 883041291; 15360202 AB - Succinic acid, a four-carbon diacid, has been the focus of many research projects aimed at developing more economically viable methods of fermenting sugar-containing natural materials. Succinic acid fermentation processes also consume CO sub(2), thereby potentially contributing to reductions in CO sub(2) emissions. Succinic acid could also become a commodity used as an intermediate in the chemical synthesis and manufacture of synthetic resins and biodegradable polymers. Much attention has been given recently to the use of microorganisms to produce succinic acid as an alternative to chemical synthesis. We have attempted to maximize succinic acid production by Actinobacillus succinogenes using an experimental design methodology for optimizing the concentrations of the medium components. The first experiment consisted of a 2 super(4-1) fractional factorial design, and the second entailed a Central Composite Rotational Design so as to achieve optimal conditions. The optimal concentrations of nutrients predicted by the model were: NaHCO sub(3), 10.0 g l super(-1); MgSO sub(4), 3.0 g l super(-1); yeast extract, 2.0 g l super(-1); KH sub(2)PO sub(4). 5.0 g l super(-1); these were experimentally validated. Under the best conversion conditions, as determined by statistical analysis, the production of succinic acid was carried out in an instrumented bioreactor using sugarcane bagasse hemicellulose hydrolysate, yielding a concentration of 22.5 g l super(-1). JF - Journal of Industrial Microbiology & Biotechnology AU - Borges, Elcio Ribeiro AU - Pereira, Nei AD - Bioprocess Development Laboratories, School of Chemistry, Technology Center, Federal University of Rio de Janeiro, Rio de Janeiro, 21949-900, Brazil, nei@eq.ufrj.br Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 1001 EP - 1011 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 38 IS - 8 SN - 1367-5435, 1367-5435 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Resins KW - Actinobacillus KW - Fermentation KW - Statistical analysis KW - Nutrients KW - Biodegradability KW - Models KW - hemicellulose KW - Bagasse KW - Bioreactors KW - Microorganisms KW - Carbon dioxide KW - Succinic acid KW - Hydrolysates KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - W 30950:Waste Treatment & Pollution Clean-up KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883041291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Industrial+Microbiology+%26+Biotechnology&rft.atitle=Succinic+acid+production+from+sugarcane+bagasse+hemicellulose+hydrolysate+by+Actinobacillus+succinogenes&rft.au=Borges%2C+Elcio+Ribeiro%3BPereira%2C+Nei&rft.aulast=Borges&rft.aufirst=Elcio&rft.date=2011-08-01&rft.volume=38&rft.issue=8&rft.spage=1001&rft.isbn=&rft.btitle=&rft.title=Journal+of+Industrial+Microbiology+%26+Biotechnology&rft.issn=13675435&rft_id=info:doi/10.1007%2Fs10295-010-0874-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2013-12-04 N1 - SubjectsTermNotLitGenreText - Resins; Fermentation; Statistical analysis; Nutrients; Biodegradability; hemicellulose; Models; Bagasse; Bioreactors; Microorganisms; Carbon dioxide; Succinic acid; Hydrolysates; Actinobacillus DO - http://dx.doi.org/10.1007/s10295-010-0874-7 ER - TY - JOUR T1 - Preclinical Lymphatic Imaging AN - 883038084; 15154866 AB - Noninvasive in vivo imaging of lymphatic vessels and lymphatic nodes is expected to fulfill the purpose of analyzing lymphatic vessels and their function, understanding molecular mechanisms of lymphangiogenesis and lymphatic spread of tumors, and utilizing lymphatic molecular markers as a prognostic or diagnostic indicator. In this review, we provide a comprehensive summary of in vivo imaging modalities for detecting lymphatic vessels, lymphatic drainage, and lymphatic nodes, which include conventional lymphatic imaging techniques such as dyes and radionuclide scintigraphy as well as novel techniques for lymphatic imaging such as optical imaging, computed tomography, magnetic resonance imaging, ultrasound, positron emission tomography using lymphatic biomarkers, photoacoustic imaging, and combinations of multiple modalities. The field of lymphatic imaging is ever evolving, and technological advances, combined with the development of new contrast agents, continue to improve the research of lymphatic vascular system in health and disease states as well as to improve the accuracy of diagnosis in the relevant diseases. JF - Molecular Imaging and Biology AU - Zhang, Fan AU - Niu, Gang AU - Lu, Guangming AU - Chen, Xiaoyuan AD - Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), 31 Center Drive, Suite 1C14, Bethesda, MD, 20892, USA Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 599 EP - 612 PB - Springer Science+Business Media, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 13 IS - 4 SN - 1536-1632, 1536-1632 KW - Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Drainage KW - Magnetic resonance imaging KW - Tumors KW - Scintigraphy KW - biomarkers KW - Dyes KW - Computed tomography KW - Photoacoustics KW - Contrast media KW - Positron emission tomography KW - Radioisotopes KW - Nodes KW - Ultrasound KW - Lymphatic system KW - Vascular system KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883038084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Imaging+and+Biology&rft.atitle=Preclinical+Lymphatic+Imaging&rft.au=Zhang%2C+Fan%3BNiu%2C+Gang%3BLu%2C+Guangming%3BChen%2C+Xiaoyuan&rft.aulast=Zhang&rft.aufirst=Fan&rft.date=2011-08-01&rft.volume=13&rft.issue=4&rft.spage=599&rft.isbn=&rft.btitle=&rft.title=Molecular+Imaging+and+Biology&rft.issn=15361632&rft_id=info:doi/10.1007%2Fs11307-010-0421-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Drainage; Magnetic resonance imaging; Tumors; biomarkers; Scintigraphy; Dyes; Computed tomography; Radioisotopes; Positron emission tomography; Contrast media; Photoacoustics; Nodes; Ultrasound; Lymphatic system; Vascular system DO - http://dx.doi.org/10.1007/s11307-010-0421-y ER - TY - JOUR T1 - Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii AN - 883033103; 15326949 AB - A high throughput screen for inhibitors of the oncogenic transcription factor activator protein-1 (AP-1) was applied to the NCI repository of natural product extracts. The liphophilic extract of the plant Nothospondias staudtii (Simaroubaceae) displayed significant AP-1 inhibition. Bioassay-guided fractionation of the extract lead to a new quassinoid named nothospondin ( 1), and the known compound glaucarubinone ( 2). The structure of 1 was elucidated by spectroscopic methods. Compounds 1 and 2 showed potent, dose-dependent AP-1 inhibition at noncytotoxic concentrations. JF - Bioorganic and Medicinal Chemistry Letters AU - Diyabalanage, Thushara AU - Ratnayake, Ranjala AU - Wilson, Jennifer A AU - Henrich, Curtis J AU - Beutler, John A AU - Colburn, Nancy H AU - McMahon, James B AU - Gustafson, Kirk R AD - Molecular Targets Laboratory, Center for Cancer Research, NCI-Frederick, Frederick, MD 21702, USA, gustafki@mail.nih.gov Y1 - 2011/08/01/ PY - 2011 DA - 2011 Aug 01 SP - 4397 EP - 4399 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 21 IS - 15 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - quassinoids KW - Transcription factors KW - Simaroubaceae KW - Activator protein 1 KW - natural products KW - Plant extracts KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883033103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Nothospondin%2C+a+new+AP-1+inhibitory+quassinoid+from+the+Cameroonian+plant+Nothospondias+staudtii&rft.au=Diyabalanage%2C+Thushara%3BRatnayake%2C+Ranjala%3BWilson%2C+Jennifer+A%3BHenrich%2C+Curtis+J%3BBeutler%2C+John+A%3BColburn%2C+Nancy+H%3BMcMahon%2C+James+B%3BGustafson%2C+Kirk+R&rft.aulast=Diyabalanage&rft.aufirst=Thushara&rft.date=2011-08-01&rft.volume=21&rft.issue=15&rft.spage=4397&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2011.06.044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - quassinoids; Transcription factors; Activator protein 1; natural products; Plant extracts; Simaroubaceae DO - http://dx.doi.org/10.1016/j.bmcl.2011.06.044 ER - TY - JOUR T1 - Characterizing non-constant relative potency AN - 883031064; 15331428 AB - Relative potency plays an important role in toxicology. Estimates of relative potency are used to rank chemicals by their effects, to calculate equivalent doses of test chemicals compared to a standard, and to weight contributions of constituent chemicals when evaluating mixtures. Typically relative potency is characterized by a constant dilution factor, even when non-similar dose-response curves indicate that constancy is inappropriate. Improperly regarding relative potency as constant may distort conclusions and potentially mislead investigators or policymakers. We consider a more general approach that allows relative potency to vary as a function of dose, response, or response quantile. Distinct functions can be defined, each generalizing different but equivalent descriptions of constant relative potency. When two chemicals have identical response limits, these functions all carry fundamentally equivalent information; otherwise, relative potency as a function of response quantile is distinct and embodies a modified definition of relative potency. Which definition is preferable depends on whether one views any differences in response limits as intrinsic to the chemicals or as extrinsic, arising from idiosyncrasies of data sources. We illustrate these ideas with constructed examples and real data. Relative potency functions offer a unified and principled description of relative potency for non-similar dose-response curves. JF - Regulatory Toxicology and Pharmacology AU - Dinse, Gregg E AU - Umbach, David M AD - Biostatistics Branch, National Institute of Environmental Health Sciences, Mail Drop A3-03, P.O. Box 12233, Research Triangle Park, NC 27709, USA Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 342 EP - 353 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 60 IS - 3 SN - 0273-2300, 0273-2300 KW - Environment Abstracts; Toxicology Abstracts KW - Chemicals KW - Data processing KW - Dose-response effects KW - Toxicology KW - X 24310:Pharmaceuticals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883031064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Characterizing+non-constant+relative+potency&rft.au=Dinse%2C+Gregg+E%3BUmbach%2C+David+M&rft.aulast=Dinse&rft.aufirst=Gregg&rft.date=2011-08-01&rft.volume=60&rft.issue=3&rft.spage=342&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2011.05.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2013-09-20 N1 - SubjectsTermNotLitGenreText - Data processing; Chemicals; Dose-response effects; Toxicology DO - http://dx.doi.org/10.1016/j.yrtph.2011.05.002 ER - TY - JOUR T1 - Selective updating of working memory content modulates meso-cortico-striatal activity AN - 883031059; 15321110 AB - Accumulating evidence from non-human primates and computational modeling suggests that dopaminergic signals arising from the midbrain (substantia nigra/ventral tegmental area) mediate striatal gating of the prefrontal cortex during the selective updating of working memory. Using event-related functional magnetic resonance imaging, we explored the neural mechanisms underlying the selective updating of information stored in working memory. Participants were scanned during a novel working memory task that parses the neurophysiology underlying working memory maintenance, overwriting, and selective updating. Analyses revealed a functionally coupled network consisting of a midbrain region encompassing the substantia nigra/ventral tegmental area, caudate, and dorsolateral prefrontal cortex that was selectively engaged during working memory updating compared to the overwriting and maintenance of working memory content. Further analysis revealed differential midbrain-dorsolateral prefrontal interactions during selective updating between low-performing and high-performing individuals. These findings highlight the role of this meso-cortico-striatal circuitry during the selective updating of working memory in humans, which complements previous research in behavioral neuroscience and computational modeling. JF - NeuroImage AU - Murty, Vishnu P AU - Sambataro, Fabio AU - Radulescu, Eugenia AU - Altamura, Mario AU - Iudicello, Jennifer AU - Zoltick, Bradley AU - Weinberger, Daniel R AU - Goldberg, Terry E AU - Mattay, Venkata S AD - Clinical Brain Disorder Branch, Gene Cognition and Psychosis program, NIH/NIMH Bethesda, MD 20892, USA, vsm@mail.nih.gov Y1 - 2011/08/01/ PY - 2011 DA - 2011 Aug 01 SP - 1264 EP - 1272 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 57 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Computational neuroscience KW - Primates KW - Short term memory KW - W 30910:Imaging KW - N3:11001 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883031059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Selective+updating+of+working+memory+content+modulates+meso-cortico-striatal+activity&rft.au=Murty%2C+Vishnu+P%3BSambataro%2C+Fabio%3BRadulescu%2C+Eugenia%3BAltamura%2C+Mario%3BIudicello%2C+Jennifer%3BZoltick%2C+Bradley%3BWeinberger%2C+Daniel+R%3BGoldberg%2C+Terry+E%3BMattay%2C+Venkata+S&rft.aulast=Murty&rft.aufirst=Vishnu&rft.date=2011-08-01&rft.volume=57&rft.issue=3&rft.spage=1264&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2011.05.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Short term memory; Primates DO - http://dx.doi.org/10.1016/j.neuroimage.2011.05.006 ER - TY - JOUR T1 - Functional connectivity hubs in the human brain AN - 883026529; 15321128 AB - Brain networks appear to have few and well localized regions with high functional connectivity density (hubs) for fast integration of neural processing, and their dysfunction could contribute to neuropsychiatric diseases. However the variability in the distribution of these brain hubs is unknown due in part to the overwhelming computational demands associated to their localization. Recently we developed a fast algorithm to map the local functional connectivity density (lFCD). Here we extend our method to map the global density (gFDC) taking advantage of parallel computing. We mapped the gFCD in the brain of 1031 subjects from the 1000 Functional Connectomes project and show that the strongest hubs are located in regions of the default mode network (DMN) and in sensory cortices, whereas subcortical regions exhibited the weakest hubs. The strongest hubs were consistently located in ventral precuneus/cingulate gyrus (previously identified by other analytical methods including lFCD) and in primary visual cortex (BA 17/18), which highlights their centrality to resting connectivity networks. In contrast and after rescaling, hubs in prefrontal regions had lower gFCD than lFCD, which suggests that their local functional connectivity (as opposed to long-range connectivity) prevails in the resting state. The power scaling of the probability distribution of gFCD hubs (as for lFCD) was consistent across research centers further corroborating the "scale-free" topology of brain networks. Within and between-subject variability for gFCD were twice than that for lFCD (20% vs. 12% and 84% vs. 34%, respectively) suggesting that gFCD is more sensitive to individual differences in functional connectivity. JF - NeuroImage AU - Tomasi, Dardo AU - Volkow, Nora D AD - National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, 20892, USA, tomasi@bnl.gov Y1 - 2011/08/01/ PY - 2011 DA - 2011 Aug 01 SP - 908 EP - 917 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 57 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Algorithms KW - Neural networks KW - W 30910:Imaging KW - N3:11002 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883026529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Functional+connectivity+hubs+in+the+human+brain&rft.au=Tomasi%2C+Dardo%3BVolkow%2C+Nora+D&rft.aulast=Tomasi&rft.aufirst=Dardo&rft.date=2011-08-01&rft.volume=57&rft.issue=3&rft.spage=908&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2011.05.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Neural networks DO - http://dx.doi.org/10.1016/j.neuroimage.2011.05.024 ER - TY - JOUR T1 - Minigenomes, transcription and replication competent virus-like particles and beyond: Reverse genetics systems for filoviruses and other negative stranded hemorrhagic fever viruses AN - 883020252; 15331442 AB - Reverse-genetics systems are powerful tools enabling researchers to study the replication cycle of RNA viruses, including filoviruses and other hemorrhagic fever viruses, as well as to discover new antivirals. They include full-length clone systems as well as a number of life cycle modeling systems. Full-length clone systems allow for the generation of infectious, recombinant viruses, and thus are an important tool for studying the virus replication cycle in its entirety. In contrast, life cycle modeling systems such as minigenome and transcription and replication competent virus-like particle systems can be used to simulate and dissect parts of the virus life cycle outside of containment facilities. Minigenome systems are used to model viral genome replication and transcription, whereas transcription and replication competent virus-like particle systems also model morphogenesis and budding as well as infection of target cells. As such, these modeling systems have tremendous potential to further the discovery and screening of new antivirals targeting hemorrhagic fever viruses. This review provides an overview of currently established reverse genetics systems for hemorrhagic fever-causing negative-sense RNA viruses, with a particular emphasis on filoviruses, and the potential application of these systems for antiviral research. JF - Antiviral Research AU - Hoenen, Thomas AU - Groseth, Allison AU - de Kok-Mercado, Fabian AU - Kuhn, Jens H AU - Wahl-Jensen, Victoria AD - Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA, victoria.jensen@nih.gov Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 195 EP - 208 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 91 IS - 2 SN - 0166-3542, 0166-3542 KW - Genetics Abstracts; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Budding KW - Genomes KW - Hemorrhage KW - Hemorrhagic fever KW - Infection KW - Life cycle KW - Morphogenesis KW - RNA viruses KW - Replication KW - Reviews KW - Transcription KW - Virus-like particles KW - Filovirus KW - A 01340:Antibiotics & Antimicrobials KW - G 07880:Human Genetics KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883020252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=Minigenomes%2C+transcription+and+replication+competent+virus-like+particles+and+beyond%3A+Reverse+genetics+systems+for+filoviruses+and+other+negative+stranded+hemorrhagic+fever+viruses&rft.au=Hoenen%2C+Thomas%3BGroseth%2C+Allison%3Bde+Kok-Mercado%2C+Fabian%3BKuhn%2C+Jens+H%3BWahl-Jensen%2C+Victoria&rft.aulast=Hoenen&rft.aufirst=Thomas&rft.date=2011-08-01&rft.volume=91&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2011.06.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-09-10 N1 - SubjectsTermNotLitGenreText - Genomes; Virus-like particles; Replication; Reviews; Morphogenesis; Life cycle; Hemorrhagic fever; Transcription; RNA viruses; Hemorrhage; Infection; Budding; Filovirus DO - http://dx.doi.org/10.1016/j.antiviral.2011.06.003 ER - TY - JOUR T1 - In Vivo MRI Tracking of Cell Invasion and Migration in a Rat Glioma Model AN - 883017033; 15154859 AB - Purpose: Malignant brain tumors are characterized by extensive infiltration into the normal brain tissue. Tumor migration is a complicated process which results from the interplay of a number of mechanisms, and the extent to which anatomic structure determined the migration pattern has not been extensively addressed. In the present study, we labeled C6 glioma cells with iron oxide nanoparticles and monitored the fate of the cells in vivo with magnetic resonance imaging (MRI). Procedures: C6 glioma cells were labeled with ferumoxide-poly-l-lysine complexes and their migration in the brains of rats tracked by T2-weighted MRI. The same amount of iron-laden cells were implanted into the caudate nucleus (CN) and at the vicinity of anterior commissure (AC), respectively, and MRI was performed during the course of 20-day monitoring period to track tumor growth and migration. Results: A clear tendency of tumor migration along the white matter fiber tracts was observed in the AC group, which is consistent with the previous reports; by contrast, tumor expanded to but remained confined within the boundary of right hemisphere in the CN group. Conclusion: We successfully demonstrated the ability of MRI to investigate the impact of anatomical structure on the glioma migration pathway in vivo. JF - Molecular Imaging and Biology AU - Zhang, Fan AU - Xie, Jin AU - Liu, Gang AU - He, Yulong AU - Lu, Guangming AU - Chen, Xiaoyuan AD - Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD, 20892, USA Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 695 EP - 701 PB - Springer Science+Business Media, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 13 IS - 4 SN - 1536-1632, 1536-1632 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Adenylate cyclase KW - Animal models KW - Anterior commissure KW - Boundaries KW - Caudate nucleus KW - Cell migration KW - Fibers KW - Glioma cells KW - Hemispheric laterality KW - Magnetic resonance imaging KW - Metastases KW - Migration KW - Neuroimaging KW - Substantia alba KW - iron oxides KW - nanoparticles KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883017033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Imaging+and+Biology&rft.atitle=In+Vivo+MRI+Tracking+of+Cell+Invasion+and+Migration+in+a+Rat+Glioma+Model&rft.au=Zhang%2C+Fan%3BXie%2C+Jin%3BLiu%2C+Gang%3BHe%2C+Yulong%3BLu%2C+Guangming%3BChen%2C+Xiaoyuan&rft.aulast=Zhang&rft.aufirst=Fan&rft.date=2011-08-01&rft.volume=13&rft.issue=4&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Molecular+Imaging+and+Biology&rft.issn=15361632&rft_id=info:doi/10.1007%2Fs11307-010-0401-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-09-10 N1 - SubjectsTermNotLitGenreText - Hemispheric laterality; Neuroimaging; iron oxides; Magnetic resonance imaging; Animal models; Substantia alba; Caudate nucleus; Migration; Metastases; Fibers; Glioma cells; Boundaries; Cell migration; Anterior commissure; nanoparticles; Adenylate cyclase DO - http://dx.doi.org/10.1007/s11307-010-0401-2 ER - TY - JOUR T1 - A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice. AN - 881089024; 21625009 AB - Lung tumors from smokers as well as lung tumors from mice exposed to tobacco carcinogens such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), often carry mutations in K-ras, which activates downstream-signaling pathways such as PI3K/AKT/mTOR pathway. Mice with genetic deletion of one of three isoforms of AKT were used to investigate the role of AKT in mutant K-ras-induced lung tumorigenesis in mice. Although deletion of Akt1 or Akt2 decreased NNK-induced lung tumor formation by 90%, deletion of Akt2 failed to decrease lung tumorigenesis in two other mouse models driven by mutant K-ras. Genetic mapping showed that Akt2 was tightly linked to the cytochrome P450 Cyp2a locus on chromosome 7. Consequently, targeted deletion of Akt2 created linkage to a strain-specific Cyp2a5 polymorphism that decreased activation of NNK in vitro. Mice with this Cyp2a5 polymorphism had decreased NNK-induced DNA adduct formation in vivo and decreased NNK-induced lung tumorigenesis. These studies support human epidemiological studies linking CYP2A polymorphisms with lung cancer risk in humans and highlight the need to confirm phenotypes of genetically engineered mice in multiple mouse strains. JF - Carcinogenesis AU - Hollander, M Christine AU - Zhou, Xin AU - Maier, Colleen R AU - Patterson, Andrew D AU - Ding, Xinxin AU - Dennis, Phillip A AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 1279 EP - 1284 VL - 32 IS - 8 KW - Carcinogens KW - 0 KW - Nitrosamines KW - 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone KW - 7S395EDO61 KW - Steroid Hydroxylases KW - EC 1.14.- KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - steroid hormone 7-alpha-hydroxylase KW - Akt2 protein, mouse KW - EC 2.7.11.1 KW - Proto-Oncogene Proteins c-akt KW - Index Medicus KW - Animals KW - Immunoblotting KW - Carcinogens -- toxicity KW - Mice KW - Mice, Knockout KW - Tobacco -- toxicity KW - Mice, Inbred A KW - Polymerase Chain Reaction KW - Lung -- drug effects KW - Mice, Inbred C57BL KW - Microsomes, Liver -- drug effects KW - Proto-Oncogene Proteins c-akt -- physiology KW - Female KW - Male KW - Nitrosamines -- toxicity KW - Polymorphism, Genetic -- genetics KW - Lung Neoplasms -- genetics KW - Steroid Hydroxylases -- genetics KW - Lung Neoplasms -- chemically induced KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881089024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=A+Cyp2a+polymorphism+predicts+susceptibility+to+NNK-induced+lung+tumorigenesis+in+mice.&rft.au=Hollander%2C+M+Christine%3BZhou%2C+Xin%3BMaier%2C+Colleen+R%3BPatterson%2C+Andrew+D%3BDing%2C+Xinxin%3BDennis%2C+Phillip+A&rft.aulast=Hollander&rft.aufirst=M&rft.date=2011-08-01&rft.volume=32&rft.issue=8&rft.spage=1279&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgr097 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-30 N1 - Date created - 2011-08-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2000 Sep 15;60(18):5074-9 [11016631] Oncogene. 2011 Apr 14;30(15):1812-21 [21242979] Arch Biochem Biophys. 2000 Dec 15;384(2):418-24 [11368333] Science. 2001 Jun 1;292(5522):1728-31 [11387480] J Pharmacol Exp Ther. 2002 Aug;302(2):416-23 [12130698] Cancer Res. 2003 Nov 15;63(22):7581-3 [14633670] Cancer Res. 2003 Nov 15;63(22):8057-61 [14633739] Nature. 1989 Jun 22;339(6226):632-4 [2733794] Cancer Res. 1991 Oct 15;51(20):5557-64 [1913675] Cancer Res. 1992 May 1;52(9 Suppl):2665s-2669s [1562997] Pharmacogenetics. 1992 Feb;2(1):32-7 [1302041] Mol Carcinog. 1993;8(3):177-85 [8216736] Carcinogenesis. 1995 May;16(5):1065-9 [7767966] Exp Lung Res. 1998 Jul-Aug;24(4):481-97 [9659579] Mutat Res. 1999 Mar 8;424(1-2):127-42 [10064856] Drug Metab Dispos. 2004 Dec;32(12):1516-21 [15333516] Mutat Res. 2005 May 2;572(1-2):58-72 [15790490] Carcinogenesis. 2005 May;26(5):875-82 [15471897] Carcinogenesis. 2005 Nov;26(11):1947-55 [15958517] Cancer Biol Ther. 2006 May;5(5):511-7 [16582591] Toxicol Sci. 2007 Feb;95(2):331-9 [17093202] Cancer Res. 2007 Aug 15;67(16):7825-32 [17699788] Nature. 2008 Apr 3;452(7187):633-7 [18385738] Nature. 2008 Apr 3;452(7187):638-42 [18385739] Neoplasia. 2008 Aug;10(8):866-72 [18683321] PLoS Genet. 2009 Jan;5(1):e1000331 [19132132] Drug Metab Dispos. 2009 Oct;37(10):2018-27 [19608696] Nat Genet. 2010 May;42(5):448-53 [20418888] Drug Metab Dispos. 2011 Feb;39(2):330-6 [21051534] Nature. 2001 Apr 26;410(6832):1111-6 [11323676] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgr097 ER - TY - JOUR T1 - Synthetic liposomes are protective from bleomycin-induced lung toxicity. AN - 881001564; 21602446 AB - Idiopathic pulmonary fibrosis is a devastating disease characterized by a progressive, irreversible, and ultimately lethal form of lung fibrosis. Except for lung transplantation, no effective treatment options currently exist. The bleomycin animal model is one of the best studied models of lung injury and fibrosis. A previous study using mouse tumor models observed that liposome-encapsulated bleomycin exhibited reduced lung toxicity. Therefore, we hypothesized that airway delivery of synthetic phosphatidylcholine-containing liposomes alone would protect mice from bleomycin-induced lung toxicity. C57BL/6 mice were administered uncharged multilamellar liposomes (100 μl) or PBS vehicle on day 0 by airway delivery. Bleomycin (3.33 U/kg) or saline vehicle was then given intratracheally on day 1 followed by four additional separate doses of liposomes on days 4, 8, 12, and 16. Fluorescent images of liposomes labeled with 1,1'-dioctadecyl-3,3,3',3' tetramethylindocarbocyanine perchlorate confirmed effective and widespread delivery of liposomes to the lower respiratory tract as well as uptake primarily by alveolar macrophages and to a lesser extent by type II alveolar epithelial cells. Results at day 22, 3 wk after bleomycin treatment, showed that airway delivery of liposomes before and after intratracheal administration of bleomycin significantly reduced bleomycin-induced lung toxicity as evidenced by less body weight loss, chronic lung inflammation, and fibrosis as well as improved lung compliance compared with controls. These data indicate that airway-delivered synthetic liposomes represent a novel treatment strategy to reduce the lung toxicity associated with bleomycin in a mouse model. JF - American journal of physiology. Lung cellular and molecular physiology AU - Gwinn, William M AU - Kapita, Mayanga C AU - Wang, Ping M AU - Cesta, Mark F AU - Martin, William J AD - Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. Y1 - 2011/08// PY - 2011 DA - August 2011 SP - L207 EP - L217 VL - 301 IS - 2 KW - Carbocyanines KW - 0 KW - Fluorescent Dyes KW - Liposomes KW - Bleomycin KW - 11056-06-7 KW - 3,3'-dioctadecylindocarbocyanine KW - 40957-95-7 KW - Index Medicus KW - Animals KW - Intubation, Intratracheal KW - Weight Loss -- drug effects KW - Mice, Inbred C57BL KW - Mice KW - Chronic Disease KW - Administration, Inhalation KW - Female KW - Pneumonia -- prevention & control KW - Pneumonia -- chemically induced KW - Liposomes -- administration & dosage KW - Bleomycin -- administration & dosage KW - Pulmonary Fibrosis -- chemically induced KW - Pulmonary Fibrosis -- prevention & control KW - Liposomes -- chemical synthesis KW - Bleomycin -- poisoning KW - Lung -- drug effects KW - Lung -- physiopathology KW - Bleomycin -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881001564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Lung+cellular+and+molecular+physiology&rft.atitle=Synthetic+liposomes+are+protective+from+bleomycin-induced+lung+toxicity.&rft.au=Gwinn%2C+William+M%3BKapita%2C+Mayanga+C%3BWang%2C+Ping+M%3BCesta%2C+Mark+F%3BMartin%2C+William+J&rft.aulast=Gwinn&rft.aufirst=William&rft.date=2011-08-01&rft.volume=301&rft.issue=2&rft.spage=L207&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Lung+cellular+and+molecular+physiology&rft.issn=1522-1504&rft_id=info:doi/10.1152%2Fajplung.00149.2010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-28 N1 - Date created - 2011-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 2002 Oct 15;169(8):4504-10 [12370387] Respir Res. 2001;2(6):353-64 [11737935] J Cell Mol Med. 2002 Oct-Dec;6(4):465-74 [12611636] Am J Respir Med. 2002;1(6):417-33 [14720029] Toxicol Appl Pharmacol. 2004 Mar 1;195(2):218-31 [14998687] Analyst. 1969 Jul;94(120):575-84 [5804368] Clin Exp Immunol. 1986 Feb;63(2):261-70 [3516464] Am Rev Respir Dis. 1987 Jul;136(1):113-8 [2440355] Am Rev Respir Dis. 1987 Sep;136(3):651-6 [3307569] J Appl Physiol (1985). 1989 Apr;66(4):1846-51 [2732176] J Appl Physiol (1985). 1991 Mar;70(3):1300-8 [1709634] Exp Lung Res. 1991 Jul-Aug;17(4):687-705 [1657589] J Clin Invest. 1991 Dec;88(6):1976-81 [1752956] J Appl Physiol (1985). 1991 Oct;71(4):1270-6 [1757348] Am J Physiol. 1992 Apr;262(4 Pt 1):L367-85 [1566854] Exp Lung Res. 1992 Mar-Apr;18(2):191-204 [1572329] Immunology. 1992 May;76(1):60-4 [1628902] Am Rev Respir Dis. 1993 Oct;148(4 Pt 1):834-6 [8214936] JAMA. 1994 Nov 9;272(18):1433-8 [7933425] N Engl J Med. 1996 May 30;334(22):1417-21 [8618579] Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 1):1002-5 [8887598] Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Nov;35(11):1163-72 [9493441] Eur Respir J. 1998 Aug;12(2):284-7 [9727775] Eur Respir J. 1998 Sep;12(3):533-9 [9762775] Biull Eksp Biol Med. 1998 Oct;126(10):455-8 [9825150] Am J Respir Crit Care Med. 1998 Dec;158(6):1890-9 [9847283] J Immunoassay Immunochem. 2006;27(1):31-44 [16450867] Bull Exp Biol Med. 2006 Jun;141(6):682-4 [17364048] Proc Am Thorac Soc. 2007 Jul;4(3):252-7 [17607008] Adv Exp Med Biol. 2007;620:117-28 [18217339] Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L152-60 [17993587] Int J Biochem Cell Biol. 2008;40(3):362-82 [17936056] Curr Drug Saf. 2006 May;1(2):159-68 [18690927] Respir Physiol Neurobiol. 2008 Nov 30;163(1-3):244-55 [18632313] Respir Care. 2009 Sep;54(9):1203-8 [19712497] Adv Exp Med Biol. 2009;653:74-97 [19799113] Am J Physiol Lung Cell Mol Physiol. 2010 Mar;298(3):L348-60 [20034962] Eur Respir J. 1999 Sep;14(3):565-73 [10543276] Am J Physiol Lung Cell Mol Physiol. 2001 Apr;280(4):L689-94 [11238009] Drug Deliv. 2001 Jan-Mar;8(1):1-7 [11280437] Bull Exp Biol Med. 2001 Feb;131(2):191-4 [11391410] Am J Physiol Lung Cell Mol Physiol. 2001 Dec;281(6):L1327-34 [11704526] Am J Physiol Lung Cell Mol Physiol. 2002 Nov;283(5):L1079-85 [12376361] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1152/ajplung.00149.2010 ER - TY - JOUR T1 - Gestational and chronic low-dose PFOA exposures and mammary gland growth and differentiation in three generations of CD-1 mice. AN - 880996663; 21501981 AB - Prenatal exposure to perfluorooctanoic acid (PFOA), a ubiquitous industrial surfactant, has been reported to delay mammary gland development in female mouse offspring (F1) and the treated lactating dam (P0) after gestational treatments at 3 and 5 mg PFOA/kg/day. We investigated the consequences of gestational and chronic PFOA exposure on F1 lactational function and subsequent development of F2 offspring. We treated P0 dams with 0, 1, or 5 mg PFOA/kg/day on gestation days 1-17. In addition, a second group of P0 dams treated with 0 or 1 mg/kg/day during gestation and their F1 and F2 offspring received continuous PFOA exposure (5 ppb) in drinking water. Resulting adult F1 females were bred to generate F2 offspring, whose development was monitored over postnatal days (PNDs) 1-63. F1 gland function was assessed on PND10 by timed-lactation experiments. Mammary tissue was isolated from P0, F1, and F2 females throughout the study and histologically assessed for age-appropriate development. PFOA-exposed F1 dams exhibited diminished lactational morphology, although F1 maternal behavior and F2 offspring body weights were not significantly affected by P0 treatment. In addition to reduced gland development in F1 females under all exposures, F2 females with chronic low-dose drinking-water exposures exhibited visibly slowed mammary gland differentiation from weaning onward. F2 females derived from 5 mg/kg PFOA-treated P0 dams displayed gland morphology similar to F2 chronic water exposure groups on PNDs 22-63. Gestational PFOA exposure induced delays in mammary gland development and/or lactational differentiation across three generations. Chronic, low-dose PFOA exposure in drinking water was also sufficient to alter mammary morphological development in mice, at concentrations approximating those found in contaminated human water supplies. JF - Environmental health perspectives AU - White, Sally S AU - Stanko, Jason P AU - Kato, Kayoko AU - Calafat, Antonia M AU - Hines, Erin P AU - Fenton, Suzanne E AD - National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 1070 EP - 1076 VL - 119 IS - 8 KW - Caprylates KW - 0 KW - Fluorocarbons KW - perfluorooctanoic acid KW - 947VD76D3L KW - Index Medicus KW - Lactation -- drug effects KW - Animals KW - Gestational Age KW - Mice KW - Female KW - Prenatal Exposure Delayed Effects KW - Pregnancy KW - Mammary Glands, Animal -- drug effects KW - Fluorocarbons -- toxicity KW - Mammary Glands, Animal -- growth & development KW - Caprylates -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/880996663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Gestational+and+chronic+low-dose+PFOA+exposures+and+mammary+gland+growth+and+differentiation+in+three+generations+of+CD-1+mice.&rft.au=White%2C+Sally+S%3BStanko%2C+Jason+P%3BKato%2C+Kayoko%3BCalafat%2C+Antonia+M%3BHines%2C+Erin+P%3BFenton%2C+Suzanne+E&rft.aulast=White&rft.aufirst=Sally&rft.date=2011-08-01&rft.volume=119&rft.issue=8&rft.spage=1070&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1002741 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-28 N1 - Date created - 2011-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Sci. 2002 May;67(1):63-74 [11961217] Toxicol Sci. 2010 May;115(1):214-24 [20118188] Toxicol Sci. 2004 Apr;78(2):248-57 [14718648] J Occup Health. 2004 Mar;46(2):141-7 [15090689] Toxicol Appl Pharmacol. 2004 Jul 15;198(2):231-41 [15236955] Arch Environ Contam Toxicol. 1977;6(2-3):279-92 [409355] Environ Sci Technol. 2004 Oct 15;38(20):5379-85 [15543740] Chem Biol Interact. 2005 Aug 15;155(3):165-80 [16098497] Environ Sci Technol. 2006 Jan 1;40(1):32-44 [16433330] Toxicol Sci. 2006 Apr;90(2):510-8 [16415327] J Occup Environ Med. 2006 Aug;48(8):759-70 [16902368] Toxicol Sci. 2007 Feb;95(2):462-73 [17098816] Toxicol Sci. 2007 Mar;96(1):133-44 [17132714] Chemosphere. 2007 May;68(1):105-11 [17267015] Environ Health Perspect. 2007 Nov;115(11):1596-602 [18007991] Toxicol Sci. 2009 Feb;107(2):331-41 [19005225] Reprod Toxicol. 2009 Jun;27(3-4):299-306 [19013232] Reprod Toxicol. 2009 Jun;27(3-4):289-98 [19095057] Environ Sci Technol. 2002 Apr 1;36(7):146A-152A [11999053] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.1002741 ER - TY - JOUR T1 - Cadmium, lead, and mercury in relation to reproductive hormones and anovulation in premenopausal women. AN - 880995829; 21543284 AB - Metals can interfere with hormonal functioning by binding at the receptor site and through indirect mechanisms; thus, they may be associated with hormonal changes in premenopausal women. We examined the associations between cadmium, lead, and mercury, and anovulation and patterns of reproductive hormones [estradiol, progesterone, follicle-stimulating hormone (FSH), luteinizing hormone] among 252 premenopausal women 18-44 years of age who were enrolled in the BioCycle Study in Buffalo, New York. Women were followed for up to two menstrual cycles, with serum samples collected up to eight times per cycle. Metal concentrations were determined at baseline in whole blood by inductively coupled mass spectroscopy. Marginal structural models with stabilized inverse probability weights and nonlinear mixed models with harmonic terms were used to estimate the effects of cadmium, lead, and mercury on reproductive hormone levels during the menstrual cycle and anovulation. Geometric mean (interquartile range) cadmium, lead, and mercury levels were 0.29 (0.19-0.43) μg/L, 0.93 (0.68-1.20) μg/dL, and 1.03 (0.58-2.10) μg/L, respectively. We observed decreases in mean FSH with increasing cadmium [second vs. first tertile: -10.0%; 95% confidence interval (CI), -17.3% to -2.5%; third vs. first tertile: -8.3%; 95% CI, -16.0% to 0.1%] and increases in mean progesterone with increasing lead level (second vs. first tertile: 7.5%; 95% CI, 0.1-15.4%; third vs. first tertile: 6.8%; 95% CI, -0.8% to 14.9%). Metals were not significantly associated with anovulation. Our findings support the hypothesis that environmentally relevant levels of metals are associated with modest changes in reproductive hormone levels in healthy, premenopausal women. JF - Environmental health perspectives AU - Pollack, Anna Z AU - Schisterman, Enrique F AU - Goldman, Lynn R AU - Mumford, Sunni L AU - Albert, Paul S AU - Jones, Robert L AU - Wactawski-Wende, Jean AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, Epidemiology Branch, Rockville, Maryland, USA. Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 1156 EP - 1161 VL - 119 IS - 8 KW - Cadmium KW - 00BH33GNGH KW - Lead KW - 2P299V784P KW - Progesterone KW - 4G7DS2Q64Y KW - Estradiol KW - 4TI98Z838E KW - Luteinizing Hormone KW - 9002-67-9 KW - Follicle Stimulating Hormone KW - 9002-68-0 KW - Mercury KW - FXS1BY2PGL KW - Index Medicus KW - Young Adult KW - Mass Spectrometry KW - Estradiol -- blood KW - Humans KW - Adult KW - Luteinizing Hormone -- blood KW - Menstrual Cycle -- drug effects KW - Adolescent KW - Progesterone -- blood KW - Follicle Stimulating Hormone -- blood KW - Female KW - Mercury -- blood KW - Anovulation -- chemically induced KW - Anovulation -- blood KW - Premenopause -- blood KW - Cadmium -- blood KW - Lead -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/880995829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Cadmium%2C+lead%2C+and+mercury+in+relation+to+reproductive+hormones+and+anovulation+in+premenopausal+women.&rft.au=Pollack%2C+Anna+Z%3BSchisterman%2C+Enrique+F%3BGoldman%2C+Lynn+R%3BMumford%2C+Sunni+L%3BAlbert%2C+Paul+S%3BJones%2C+Robert+L%3BWactawski-Wende%2C+Jean&rft.aulast=Pollack&rft.aufirst=Anna&rft.date=2011-08-01&rft.volume=119&rft.issue=8&rft.spage=1156&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1003284 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-28 N1 - Date created - 2011-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Clin Pathol. 2004 Sep;122(3):332-7 [15362362] Environ Health Perspect. 2004 Jul;112(10):1099-103 [15238284] Obstet Gynecol. 1976 Nov;48(5):598-602 [980286] Br J Obstet Gynaecol. 1983 Jun;90(6):543-8 [6860600] Fundam Appl Toxicol. 1987 Nov;9(4):722-9 [3692027] Cancer Invest. 1988;6(3):245-54 [3167610] Biometrics. 1988 Dec;44(4):1049-60 [3233245] Environ Health Perspect. 1991 Feb;91:33-7 [2040248] J Biol Chem. 1994 Jun 17;269(24):16896-901 [8207012] JAMA. 1994 Jul 27;272(4):284-91 [8028141] J Clin Endocrinol Metab. 1996 Apr;81(4):1495-501 [8636357] J Appl Toxicol. 1996 Mar-Apr;16(2):159-63 [8935792] Environ Health Perspect. 1998 Feb;106 Suppl 1:217-29 [9539015] Hum Reprod Update. 1998 May-Jun;4(3):301-9 [9741713] Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):705-8 [15767353] Biometrics. 2005 Dec;61(4):1115-20; discussion 1120-2 [16401286] Am J Epidemiol. 2006 Feb 15;163(4):374-83 [16394206] J Sports Med Phys Fitness. 2006 Mar;46(1):138-42 [16596113] Environ Res. 2006 Jul;101(3):380-6 [16360143] Toxicol Appl Pharmacol. 2006 Oct 1;216(1):20-8 [16716372] Environ Health Perspect. 2007 Mar;115(3):455-62 [17431499] Environ Res. 2007 Jul;104(3):374-82 [17084837] Toxicology. 2007 Oct 8;239(3):204-12 [17719163] Fertil Steril. 2008 Feb;89(2 Suppl):e81-94 [18308071] Hum Reprod. 2008 Mar;23(3):679-87 [18192673] Biometals. 2008 Apr;21(2):143-50 [17588195] Am J Epidemiol. 2008 Sep 15;168(6):656-64 [18682488] Am J Epidemiol. 2009 Jan 1;169(1):105-12 [18974081] Paediatr Perinat Epidemiol. 2009 Mar;23(2):171-84 [19159403] Toxicol Appl Pharmacol. 2009 Aug 1;238(3):201-8 [19409405] Am J Clin Nutr. 2009 Oct;90(4):1061-9 [19692496] Environ Res. 2010 Jan;110(1):105-11 [19875111] J Environ Sci Health A Tox Hazard Subst Environ Eng. 2010;45(3):320-31 [20390873] J Appl Toxicol. 2010 Apr;30(3):242-53 [19847775] Environ Res. 2010 Jul;110(5):505-12 [20400068] Steroids. 2010 Aug-Sep;75(8-9):520-3 [20466011] Environ Health Perspect. 2010 Dec;118(12):1782-7 [20675266] Mol Endocrinol. 2000 Apr;14(4):545-53 [10770491] Biol Reprod. 2000 Jul;63(1):259-66 [10859267] Epidemiology. 2000 Sep;11(5):550-60 [10955408] Environ Res. 2002 Mar;88(3):145-55 [12051792] Biol Reprod. 2002 Jul;67(1):178-83 [12080015] JAMA. 2002 Jul 17;288(3):321-33 [12117397] Am J Epidemiol. 2003 Feb 15;157(4):355-63 [12578806] Sci Total Environ. 2003 Aug 1;312(1-3):15-21 [12873394] Med Sci Sports Exerc. 2003 Aug;35(8):1381-95 [12900694] Obstet Gynecol. 2003 Aug;102(2):317-8 [12907106] Toxicol Sci. 2004 Jan;77(1):35-40 [14514953] Arch Environ Health. 1969 Oct;19(4):478-84 [5822994] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.1003284 ER - TY - JOUR T1 - Chemical genomics profiling of environmental chemical modulation of human nuclear receptors. AN - 880995824; 21543282 AB - The large and increasing number of chemicals released into the environment demands more efficient and cost-effective approaches for assessing environmental chemical toxicity. The U.S. Tox21 program has responded to this challenge by proposing alternative strategies for toxicity testing, among which the quantitative high-throughput screening (qHTS) paradigm has been adopted as the primary tool for generating data from screening large chemical libraries using a wide spectrum of assays. The goal of this study was to develop methods to evaluate the data generated from these assays to guide future assay selection and prioritization for the Tox21 program. We examined the data from the Tox21 pilot-phase collection of approximately 3,000 environmental chemicals profiled in qHTS format against a panel of 10 human nuclear receptors (AR, ERα, FXR, GR, LXRβ, PPARγ, PPARδ, RXRα, TRβ, and VDR) for reproducibility, concordance of biological activity profiles with sequence homology of the receptor ligand binding domains, and structure-activity relationships. We determined the assays to be appropriate in terms of biological relevance. We found better concordance for replicate compounds for the agonist-mode than for the antagonist-mode assays, likely due to interference of cytotoxicity in the latter assays. This exercise also enabled us to formulate data-driven strategies for discriminating true signals from artifacts, and to prioritize assays based on data quality. The results demonstrate the feasibility of qHTS to identify the potential for environmentally relevant chemicals to interact with key toxicity pathways related to human disease induction. JF - Environmental health perspectives AU - Huang, Ruili AU - Xia, Menghang AU - Cho, Ming-Hsuang AU - Sakamuru, Srilatha AU - Shinn, Paul AU - Houck, Keith A AU - Dix, David J AU - Judson, Richard S AU - Witt, Kristine L AU - Kavlock, Robert J AU - Tice, Raymond R AU - Austin, Christopher P AD - National Institutes of Health Chemical Genomics Center, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-3370, USA. huangru@mail.nih.gov Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 1142 EP - 1148 VL - 119 IS - 8 KW - Environmental Pollutants KW - 0 KW - Estrogen Receptor alpha KW - Liver X Receptors KW - Orphan Nuclear Receptors KW - PPAR gamma KW - Peroxisome Proliferator-Activated Receptors KW - Receptors, Androgen KW - Receptors, Cytoplasmic and Nuclear KW - Receptors, Thrombin KW - Retinoid X Receptor alpha KW - Fragile X Mental Retardation Protein KW - 139135-51-6 KW - Index Medicus KW - Receptors, Thrombin -- metabolism KW - Orphan Nuclear Receptors -- metabolism KW - PPAR gamma -- antagonists & inhibitors KW - Peroxisome Proliferator-Activated Receptors -- antagonists & inhibitors KW - Humans KW - Retinoid X Receptor alpha -- antagonists & inhibitors KW - Retinoid X Receptor alpha -- agonists KW - Receptors, Thrombin -- agonists KW - Peroxisome Proliferator-Activated Receptors -- metabolism KW - Estrogen Receptor alpha -- metabolism KW - Retinoid X Receptor alpha -- metabolism KW - Peroxisome Proliferator-Activated Receptors -- agonists KW - Receptors, Thrombin -- antagonists & inhibitors KW - Receptors, Androgen -- metabolism KW - Orphan Nuclear Receptors -- agonists KW - Orphan Nuclear Receptors -- antagonists & inhibitors KW - PPAR gamma -- metabolism KW - Cell Line KW - Receptors, Cytoplasmic and Nuclear -- antagonists & inhibitors KW - Receptors, Cytoplasmic and Nuclear -- agonists KW - Environmental Pollutants -- toxicity KW - Receptors, Cytoplasmic and Nuclear -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/880995824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Chemical+genomics+profiling+of+environmental+chemical+modulation+of+human+nuclear+receptors.&rft.au=Huang%2C+Ruili%3BXia%2C+Menghang%3BCho%2C+Ming-Hsuang%3BSakamuru%2C+Srilatha%3BShinn%2C+Paul%3BHouck%2C+Keith+A%3BDix%2C+David+J%3BJudson%2C+Richard+S%3BWitt%2C+Kristine+L%3BKavlock%2C+Robert+J%3BTice%2C+Raymond+R%3BAustin%2C+Christopher+P&rft.aulast=Huang&rft.aufirst=Ruili&rft.date=2011-08-01&rft.volume=119&rft.issue=8&rft.spage=1142&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1002952 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-28 N1 - Date created - 2011-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Sci. 2009 Nov;112(1):153-63 [19502547] Toxicol Sci. 2009 Dec;112(2):385-93 [19805409] Environ Health Perspect. 2010 Apr;118(4):485-92 [20368123] Environ Health Perspect. 2010 Dec;118(12):1714-20 [20826373] Invest New Drugs. 1999;17(3):285-311 [10665480] Nature. 2000 May 25;405(6785):421-4 [10839530] Gen Physiol Biophys. 2000 Mar;19(1):73-84 [10930140] Hum Reprod Update. 2001 May-Jun;7(3):248-64 [11392371] Mol Endocrinol. 2003 Jun;17(6):985-93 [12690094] J Appl Toxicol. 2004 Jan-Feb;24(1):1-4 [14745840] Genome Res. 2004 Apr;14(4):580-90 [15059999] Toxicol Appl Pharmacol. 1988 Mar 30;93(1):72-80 [3354002] Toxicol Appl Pharmacol. 1994 Jun;126(2):276-85 [8209380] Environ Health Perspect. 1996 Oct;104(10):1084-9 [8930550] Nature. 1997 Oct 16;389(6652):753-8 [9338790] J Mol Endocrinol. 1997 Dec;19(3):207-26 [9460643] Cell. 1998 Dec 23;95(7):927-37 [9875847] Nat Rev Drug Discov. 2004 Nov;3(11):950-64 [15520817] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Neural Netw. 2006 Jul-Aug;19(6-7):723-33 [16774731] Toxicol Sci. 2007 Jan;95(1):5-12 [16963515] FEBS Lett. 2008 Jan 9;582(1):2-9 [18023286] Science. 2008 Feb 15;319(5865):906-7 [18276874] Environ Health Perspect. 2008 Mar;116(3):284-91 [18335092] Chem Res Toxicol. 2008 Mar;21(3):659-67 [18281954] J Med Chem. 2008 Apr 24;51(8):2363-71 [18363325] Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2412-7 [19196967] Risk Anal. 2009 Apr;29(4):485-7; discussion 492-7 [19076321] Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7233-8 [19363158] Environ Health Perspect. 2009 May;117(5):685-95 [19479008] Clin Breast Cancer. 2009 Jun;9 Suppl 1:S6-S17 [19561006] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.1002952 ER - TY - JOUR T1 - Neurotoxic pesticides and neurologic effects. AN - 880719055; 21803217 AB - Pesticides represent one of the largest classes of toxic chemicals produced, stored, and used in the United States and abroad. These chemicals are designed to be toxic and many, besides being toxic to the pests they are intended to control, are also toxic to nontarget species including humans. The article gives a brief review of their toxicity to humans with emphasis on their effects on the nervous system. Examples of case studies are included to illustrate their toxicity. A discussion of the possible contribution of occupational and other pesticide exposures to neurologic diseases and disorders is also included. Published by Elsevier Inc. JF - Neurologic clinics AU - Jett, David A AD - Office of Translational Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 6001 Executive Boulevard, NSC, Room 2177, MSC 9527, Bethesda, MD 20892-9527, USA. jettd@ninds.nih.gov Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 667 EP - 677 VL - 29 IS - 3 KW - Pesticides KW - 0 KW - Index Medicus KW - Infant KW - Humans KW - Adult KW - Aged KW - Male KW - Female KW - Pregnancy KW - Seizures -- chemically induced KW - Fasciculation -- chemically induced KW - Neurotoxicity Syndromes -- physiopathology KW - Pesticides -- adverse effects KW - Neurotoxicity Syndromes -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/880719055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurologic+clinics&rft.atitle=Neurotoxic+pesticides+and+neurologic+effects.&rft.au=Jett%2C+David+A&rft.aulast=Jett&rft.aufirst=David&rft.date=2011-08-01&rft.volume=29&rft.issue=3&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=Neurologic+clinics&rft.issn=1557-9875&rft_id=info:doi/10.1016%2Fj.ncl.2011.06.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-15 N1 - Date created - 2011-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ncl.2011.06.002 ER - TY - JOUR T1 - Organochlorine compounds and testicular dysgenesis syndrome: human data. AN - 879679540; 21668838 AB - Cryptorchidism, hypospadias, subfertility and testicular germ-cell tumour have been suggested to comprise a testicular dysgenesis syndrome (TDS) based on the premise that each may derive from perturbations of embryonal programming and gonadal development during foetal life. Endocrine-disrupting chemicals have been hypothesized to be associated with these disorders, given the importance of sex steroid hormones in urogenital development and homeostasis. Organochlorines are one such set of compounds which are defined as containing between one and ten covalently bonded chlorine atoms. These compounds are persistent pollutants with long half-lives, accumulate in adipose tissue when ingested, bioaccumulate and biomagnify, and have complex and variable toxicological profiles. Examples of organochlorines include dichloro-diphenyl-trichloroethane and its metabolites, polychlorinated biphenyls, and chlordane. In this comprehensive review of human epidemiologic studies which have tested for associations between organochlorines and facets of TDS, we find evidence for associations between the exposures p,p'-DDE, cis-nonachlor and trans-nonachlor with testicular germ-cell tumour. The sum of the evidence from human epidemiological studies does not indicate any association between specific organochlorines studied and cryptorchidism, hypospadias or fertility. Many other endocrine-disrupting chemicals, including additional organochlorines, have yet to be assessed in relation to disorders associated with TDS, yet study of such chemicals has strong scientific merit given the relevance of such hypotheses to urogenital development. © 2011 The Authors. International Journal of Andrology © 2011 European Academy of Andrology. JF - International journal of andrology AU - Cook, M B AU - Trabert, B AU - McGlynn, K A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20852-7234, USA. michael.cook@nih.gov Y1 - 2011/08// PY - 2011 DA - August 2011 SP - e68 EP - 84; discussion e84-5 VL - 34 IS - 4 Pt 2 KW - Hydrocarbons, Chlorinated KW - 0 KW - Index Medicus KW - Fertility KW - Humans KW - Environmental Exposure KW - Male KW - Testis -- embryology KW - Hydrocarbons, Chlorinated -- toxicity KW - Gonadal Dysgenesis -- epidemiology KW - Testis -- drug effects KW - Testis -- pathology KW - Gonadal Dysgenesis -- pathology KW - Gonadal Dysgenesis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879679540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+andrology&rft.atitle=Organochlorine+compounds+and+testicular+dysgenesis+syndrome%3A+human+data.&rft.au=Cook%2C+M+B%3BTrabert%2C+B%3BMcGlynn%2C+K+A&rft.aulast=Cook&rft.aufirst=M&rft.date=2011-08-01&rft.volume=34&rft.issue=4+Pt+2&rft.spage=e68&rft.isbn=&rft.btitle=&rft.title=International+journal+of+andrology&rft.issn=1365-2605&rft_id=info:doi/10.1111%2Fj.1365-2605.2011.01171.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-19 N1 - Date created - 2011-07-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bull Environ Contam Toxicol. 1974 Jan;11(1):64-9 [4433785] Br Med J (Clin Res Ed). 1986 Nov 29;293(6559):1398-401 [3026550] IARC Monogr Eval Carcinog Risks Hum Suppl. 1987;7:1-440 [3482203] J Natl Cancer Inst. 1989 Nov 1;81(21):1668-9 [2795697] BMJ. 1992 Sep 12;305(6854):609-13 [1393072] Environ Res. 1992 Oct;59(1):202-16 [1425510] Endocrinology. 1994 Jul;135(1):175-82 [8013351] Nature. 1995 Jun 15;375(6532):581-5 [7791873] Environ Health Perspect. 1995 Oct;103 Suppl 7:141-5 [8593861] Environ Health Perspect. 1996 Aug;104 Suppl 4:741-803 [8880001] J Expo Sci Environ Epidemiol. 2011 May-Jun;21(3):234-46 [20216575] Int J Epidemiol. 2009 Dec;38(6):1532-42 [19776243] Environ Health Perspect. 1997 Jan;105(1):13-4 [9074863] Int J Cancer. 2006 Jun 15;118(12):3099-111 [16395710] Epidemiology. 2006 Jul;17(4):450-8 [16755259] Environ Health Perspect. 2006 Jul;114(7):1133-8 [16835070] Nat Clin Pract Urol. 2006 Oct;3(10):532-43 [17031378] Environ Health Perspect. 2006 Nov;114(11):1670-6 [17107851] J Hazard Mater. 2007 May 8;143(1-2):102-11 [17011119] J Androl. 2007 May-Jun;28(3):423-34 [17192596] Environ Res. 2007 Nov;105(3):364-9 [17532317] Environ Health Perspect. 2007 Dec;115 Suppl 1:8-14 [18174944] Environ Health Perspect. 2008 Jan;116(1):70-7 [18197302] J Natl Cancer Inst. 2008 May 7;100(9):663-71 [18445826] Hum Reprod. 2008 Aug;23(8):1708-18 [18503055] Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2012-8 [18708392] Int J Hyg Environ Health. 2008 Oct;211(5-6):624-38 [18550430] Sex Dev. 2008;2(4-5):260-7 [18987500] Cancer Res. 2009 Mar 1;69(5):1901-9 [19223531] Med Sci Monit. 2009 Jun;15(6):RA137-45 [19478717] Crit Rev Toxicol. 2009;39(4):299-331 [19514916] Cancer Res. 2009 Jun 15;69(12):5241-50 [19491264] Hum Reprod. 2009 Sep;24(9):2053-60 [19443456] Environ Health Perspect. 2009 Sep;117(9):1472-6 [19750116] Clin Endocrinol (Oxf). 2009 Oct;71(4):459-65 [19222487] Sci Total Environ. 2009 Dec 1;407(24):6109-19 [19773016] Environ Health Perspect. 2009 Oct;117(10):1514-9 [20019899] Hum Reprod. 2010 Apr;25(4):1084-6 [20097921] Birth Defects Res A Clin Mol Teratol. 2010 Apr;88(4):241-50 [20196143] Cancer Epidemiol Biomarkers Prev. 2010 May;19(5):1151-9 [20447912] Int J Androl. 2010 Apr;33(2):298-303 [20132348] Best Pract Res Clin Endocrinol Metab. 2010 Apr;24(2):291-310 [20541153] Semin Pediatr Surg. 2010 Aug;19(3):215-24 [20610195] Chemosphere. 2010 Jul;80(6):641-6 [20494400] Sci Total Environ. 2010 Jul 1;408(15):2874-84 [19686961] Arch Environ Occup Health. 2010 Jul-Sep;65(3):127-34 [20705572] Sci Total Environ. 2010 Sep 15;408(20):4412-9 [20643475] Br J Cancer. 2010 Oct 26;103(9):1467-74 [20978513] Int J Epidemiol. 2010 Dec;39(6):1605-18 [20660640] Arch Environ Contam Toxicol. 1997 Jul;33(1):104-8 [9216878] Hum Reprod. 2005 Jan;20(1):208-15 [15567884] Environ Health Perspect. 2005 Feb;113(2):220-4 [15687061] Environ Health Perspect. 2005 Apr;113(4):425-30 [15811833] Reprod Toxicol. 2005 Jul-Aug;20(2):215-20 [15907656] Epidemiology. 2005 Jul;16(4):487-93 [15951666] Environ Health. 2005;4:26 [16280075] J Androl. 2006 Jan-Feb;27(1):16-27 [16400073] Cancer Epidemiol Biomarkers Prev. 2000 Mar;9(3):271-7 [10750665] Environ Health Perspect. 2000 Oct;108(10):961-6 [11049816] Lancet. 2000 Oct 7;356(9237):1240-1 [11072947] Eur J Pediatr Surg. 2000 Oct;10(5):304-9 [11194541] Hum Reprod. 2001 May;16(5):972-8 [11331648] Epidemiology. 2001 May;12(3):366-7 [11338320] Am J Epidemiol. 2002 Feb 15;155(4):313-22 [11836195] Eur J Endocrinol. 2002 Mar;146(3):357-63 [11888842] Int J Cancer. 2002 May 10;99(2):260-6 [11979442] Hum Reprod. 2002 Aug;17(8):1973-9 [12151423] Fertil Steril. 2002 Dec;78(6):1187-94 [12477510] Cancer. 2003 Jan 1;97(1):63-70 [12491506] Int J Androl. 2003 Feb;26(1):2-15 [12534932] Environ Health Perspect. 2003 Apr;111(4):409-13 [12676591] Environ Health Perspect. 2003 Jun;111(7):930-4 [12782494] Environ Health Perspect. 2003 Sep;111(12):1505-11 [12948891] Hum Reprod. 2004 Sep;19(9):2066-75 [15284211] Int J Androl. 2004 Oct;27(5):282-90 [15379968] Reprod Toxicol. 2004 Dec;19(2):209-14 [15501386] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2605.2011.01171.x ER - TY - JOUR T1 - Impact of classification of mixed germ-cell tumours on incidence trends of non-seminoma. AN - 879676838; 21623833 AB - Seminomas and non-seminomas [embryonal carcinomas, yolk sac tumours, teratomas, choriocarcinomas, mixed germ-cell tumours (MGCT)] are the major histological types of testicular germ-cell tumours (TGCT). TGCTs composed of both seminomatous and non-seminomatous elements have been coded as their non-seminoma component in the World Health Organization classification. In the late 1980s, a provisional International Classification of Diseases for Oncology (ICD-O) morphology code for MGCT was introduced. Using data from the Surveillance, Epidemiology and End Results Program and two population-based German cancer registries, we examined the impact of MGCT classification on TGCT trends. Cases were identified using ICD-O topography (ICD-9: 186; ICD-10: C62) and morphology codes (seminoma=9060-9062, 9064; embryonal carcinoma=9070; yolk sack tumour=9071; teratoma=9080-9084, 9102; choriocarcinoma=9100, 9101; MGCT=9085; all non-seminoma=9065-9102). As MGCTs and teratoma are often grouped as a single histological group, we analysed teratoma both including and excluding MGCTs. Between 1988 and 2007, incidence rates of MGCT in the US increased 407%. Rates of teratoma including MGCT increased 80%, whereas rates of teratoma excluding MGCT decreased 71%. Rates of embryonal carcinoma [-40%] and choriocarcinoma [-22%] also declined, suggesting that the code for MGCT is now being used for any mixed histology. Similar declines in incidence were observed in the German comparison populations. The declines in incidence of teratoma (excluding MGCT), embryonal carcinoma and choriocarcinoma in the US data since 1988 are likely in part because of increases in classifying any TGCT with mixed histology as MGCT. These results suggest that analysis of trends in specific histological types of non-seminoma should be interpreted cautiously. © 2011 The Authors. International Journal of Andrology © 2011 European Academy of Andrology. JF - International journal of andrology AU - Trabert, B AU - Stang, A AU - Cook, M B AU - Rusner, C AU - McGlynn, K A AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852-7234, USA. trabertbl@mail.nih.gov Y1 - 2011/08// PY - 2011 DA - August 2011 SP - e274 EP - e277 VL - 34 IS - 4 Pt 2 KW - Index Medicus KW - Registries KW - Pregnancy Complications, Neoplastic KW - Humans KW - Data Interpretation, Statistical KW - Testicular Neoplasms -- epidemiology KW - Male KW - Female KW - Pregnancy KW - Neoplasms, Germ Cell and Embryonal -- epidemiology KW - Clinical Coding -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879676838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+andrology&rft.atitle=Impact+of+classification+of+mixed+germ-cell+tumours+on+incidence+trends+of+non-seminoma.&rft.au=Trabert%2C+B%3BStang%2C+A%3BCook%2C+M+B%3BRusner%2C+C%3BMcGlynn%2C+K+A&rft.aulast=Trabert&rft.aufirst=B&rft.date=2011-08-01&rft.volume=34&rft.issue=4+Pt+2&rft.spage=e274&rft.isbn=&rft.btitle=&rft.title=International+journal+of+andrology&rft.issn=1365-2605&rft_id=info:doi/10.1111%2Fj.1365-2605.2011.01187.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-19 N1 - Date created - 2011-07-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Androl. 2009 Aug;32(4):306-16 [18179558] Br J Urol. 1964 Jun;36:SUPPL:1-11 [14184707] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2605.2011.01187.x ER - TY - JOUR T1 - Preclinical pharmacokinetics, metabolism, and toxicity of azurin-p28 (NSC745104) a peptide inhibitor of p53 ubiquitination. AN - 879479428; 21085965 AB - Characterize the preclinical pharmacokinetics, metabolic profile, multi-species toxicology, and antitumor efficacy of azurin-p28 (NSC 745104), an amphipathic, 28 amino acid fragment (aa 50-77) of the copper containing redox protein azurin that preferentially enters cancer cells and is currently under development for treatment of p53-positive solid tumors. An LC/MS/MS assay was developed, validated, and applied to liver microsomes, serum, and tumor cells to assess cellular uptake and metabolic stability. Pharmacokinetics was established after administration of a single intravenous dose of p28 in preclinical species undergoing chronic toxicity testing. Antitumor efficacy was assessed on human tumor xenografts. A human therapeutic dose was predicted based on efficacy and pharmacokinetic parameters. p28 is stable, showed tumor penetration consistent with selective entry into tumor cells and significantly inhibited p53-positive tumor growth. Renal clearance, volume of distribution, and metabolic profile of p28 was relatively similar among species. p28 was non-immunogenic and non-toxic in mice and non-human primates (NHP). The no observed adverse effect level (NOAEL) was 120 mg/kg iv in female mice. A NOAEL was not established for male mice due to decreased heart and thymus weights that was reversible and did not result in limiting toxicity. In contrast, the NOAEL for p28 in NHP was defined as the highest dose (120 mg/kg/dose; 1,440 mg/m(2)/dose) studied. The maximum-tolerated dose (MTD) for subchronic administration of p28 to mice is >240 mg/kg/dose (720 mg/m(2)/dose), while the MTD for subchronic administration of p28 to Cynomolgous sp. is >120 mg/kg (1,440 mg/m(2)/dose). The efficacious (murine) dose of p28 was 10 mg/kg ip per day. p28 does not exhibit preclinical immunogenicity or toxicity, has a similar metabolic profile among species, and is therapeutic in xenograft models. JF - Cancer chemotherapy and pharmacology AU - Jia, Lee AU - Gorman, Gregory S AU - Coward, Lori U AU - Noker, Patricia E AU - McCormick, David AU - Horn, Thomas L AU - Harder, J Brooks AU - Muzzio, Miguel AU - Prabhakar, Bellur AU - Ganesh, Balaji AU - Das Gupta, Tapas K AU - Beattie, Craig W AD - Developmental Therapeutics Program, National Cancer Institute, Bethesda, MD 20852, USA. Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 513 EP - 524 VL - 68 IS - 2 KW - Antineoplastic Agents KW - 0 KW - Peptide Fragments KW - Tumor Suppressor Protein p53 KW - azurin (50-77) KW - Azurin KW - 12284-43-4 KW - Index Medicus KW - Specific Pathogen-Free Organisms KW - Animals KW - Macaca fascicularis KW - Humans KW - Cell Line, Tumor KW - Mice KW - Mice, Nude KW - No-Observed-Adverse-Effect Level KW - Ubiquitination -- drug effects KW - Tumor Burden -- drug effects KW - Biotransformation KW - Xenograft Model Antitumor Assays KW - Drug Evaluation, Preclinical KW - Female KW - Male KW - Azurin -- metabolism KW - Peptide Fragments -- metabolism KW - Neoplasms -- drug therapy KW - Peptide Fragments -- adverse effects KW - Antineoplastic Agents -- pharmacokinetics KW - Azurin -- adverse effects KW - Antineoplastic Agents -- metabolism KW - Azurin -- therapeutic use KW - Tumor Suppressor Protein p53 -- metabolism KW - Antineoplastic Agents -- adverse effects KW - Tumor Suppressor Protein p53 -- antagonists & inhibitors KW - Peptide Fragments -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Peptide Fragments -- pharmacokinetics KW - Azurin -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879479428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Preclinical+pharmacokinetics%2C+metabolism%2C+and+toxicity+of+azurin-p28+%28NSC745104%29+a+peptide+inhibitor+of+p53+ubiquitination.&rft.au=Jia%2C+Lee%3BGorman%2C+Gregory+S%3BCoward%2C+Lori+U%3BNoker%2C+Patricia+E%3BMcCormick%2C+David%3BHorn%2C+Thomas+L%3BHarder%2C+J+Brooks%3BMuzzio%2C+Miguel%3BPrabhakar%2C+Bellur%3BGanesh%2C+Balaji%3BDas+Gupta%2C+Tapas+K%3BBeattie%2C+Craig+W&rft.aulast=Jia&rft.aufirst=Lee&rft.date=2011-08-01&rft.volume=68&rft.issue=2&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=1432-0843&rft_id=info:doi/10.1007%2Fs00280-010-1518-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-03 N1 - Date created - 2011-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00280-010-1518-3 ER - TY - JOUR T1 - Targeting the extrinsic apoptosis signaling pathway for cancer therapy. AN - 878823286; 21626033 AB - The extrinsic apoptosis pathway is triggered by the binding of death ligands of the tumor necrosis factor (TNF) family to their appropriate death receptors (DRs) on the cell surface. One TNF family member, TNF-related apoptosis-inducing ligand (TRAIL or Apo2L), seems to preferentially cause apoptosis of transformed cells and can be systemically administered in the absence of severe toxicity. Therefore, there has been enthusiasm for the use of TRAIL or agonist antibodies to the TRAIL DR4 and DR5 in cancer therapy. Nonetheless, many cancer cells are very resistant to TRAIL apoptosis in vitro. Therefore, there is much interest in identifying compounds that can be combined with TRAIL to amplify its apoptotic effects. In this review, I will provide a brief overview of apoptosis signaling by TRAIL and discuss apoptosis-sensitizing agents, focusing mainly on the proteasome inhibitor bortezomib (VELCADE) and some novel sensitizers that we have recently identified. Alternative ways to administer TRAIL or DR agonist antibodies as therapeutic agents will also be described. Finally, I will discuss some of the gaps in our understanding of TRAIL apoptosis signaling and suggest some research directions that may provide additional information for optimizing the targeting of the extrinsic apoptosis pathway for future cancer therapy. JF - Cancer immunology, immunotherapy : CII AU - Sayers, Thomas J AD - SAIC-Frederick, Inc., Laboratory of Experimental Immunology, Center for Cancer Research, Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702-1201, USA. sayerst@mail.nih.gov Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 1173 EP - 1180 VL - 60 IS - 8 KW - Adjuvants, Immunologic KW - 0 KW - Antibodies, Monoclonal KW - Boronic Acids KW - Proteasome Inhibitors KW - Pyrazines KW - Receptors, Tumor Necrosis Factor KW - TNF-Related Apoptosis-Inducing Ligand KW - Bortezomib KW - 69G8BD63PP KW - Index Medicus KW - Boronic Acids -- pharmacology KW - Animals KW - Pyrazines -- therapeutic use KW - Humans KW - Pyrazines -- pharmacology KW - Drug Resistance, Neoplasm KW - Antibodies, Monoclonal -- pharmacology KW - Antibodies, Monoclonal -- therapeutic use KW - Receptors, Tumor Necrosis Factor -- immunology KW - Signal Transduction -- immunology KW - Boronic Acids -- therapeutic use KW - Adjuvants, Immunologic -- therapeutic use KW - Neoplasms -- pathology KW - Immunotherapy KW - Molecular Targeted Therapy KW - Apoptosis -- immunology KW - TNF-Related Apoptosis-Inducing Ligand -- therapeutic use KW - TNF-Related Apoptosis-Inducing Ligand -- agonists KW - Neoplasms -- therapy KW - Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878823286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.atitle=Targeting+the+extrinsic+apoptosis+signaling+pathway+for+cancer+therapy.&rft.au=Sayers%2C+Thomas+J&rft.aulast=Sayers&rft.aufirst=Thomas&rft.date=2011-08-01&rft.volume=60&rft.issue=8&rft.spage=1173&rft.isbn=&rft.btitle=&rft.title=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.issn=1432-0851&rft_id=info:doi/10.1007%2Fs00262-011-1008-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-04 N1 - Date created - 2011-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00262-011-1008-4 ER - TY - JOUR T1 - Genome-wide analysis of loss of heterozygosity and copy number amplification in uterine leiomyomas using the 100K single nucleotide polymorphism array. AN - 878279511; 21497600 AB - Uterine leiomyomas (fibroids) are benign smooth muscle tumors commonly found among reproductive-aged women. Though benign, these tumors are the leading indication for hysterectomies in the United States and cause significant morbidity. Despite the importance of this tumor in women's health, relatively little is known about the molecular etiology. In this study, we used the Affymetrix 100K single nucleotide polymorphism (SNP) chip to assess whether the pattern and frequency of genome-wide loss of heterozygosity (LOH) and copy number amplifications is associated with clinical heterogeneity. Thirty-seven tumors with varying sizes and histology from eleven patients were analyzed. LOH was observed in 4/37 tumors (10.8%) and significantly associated with large-sized tumors (p<0.0014). Two tumors revealed hemizygosity on chromosome 7q, a region that has been consistently reported to have LOH. Additionally, we detected one novel region of LOH, 16p13.11 in one tumor (2.7%). Copy number amplifications were observed on all chromosomes; however, most were low-level amplifications and only detected in a single tumor. One region of amplification at 3p26.3 was detected in four tumors. Despite the use of a high-density SNP platform, our results suggest that genome-wide LOH and copy number amplifications are infrequent events and generally do not determine clinical and histologic characteristics of this disease. Published by Elsevier Inc. JF - Experimental and molecular pathology AU - Meadows, Kellen L AU - Andrews, Danica M K AU - Xu, Zongli AU - Carswell, Gleta K AU - Laughlin, Shannon K AU - Baird, Donna D AU - Taylor, Jack A AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 434 EP - 439 VL - 91 IS - 1 KW - Index Medicus KW - Chromosomes, Human, Pair 3 KW - Chromosomes, Human, Pair 16 KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Chromosomes, Human, Pair 7 KW - Female KW - Genomics KW - Gene Amplification KW - Leiomyoma -- genetics KW - DNA Copy Number Variations KW - Uterine Neoplasms -- genetics KW - Polymorphism, Single Nucleotide KW - Loss of Heterozygosity KW - Leiomyoma -- pathology KW - Gene Dosage KW - Uterine Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878279511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+molecular+pathology&rft.atitle=Genome-wide+analysis+of+loss+of+heterozygosity+and+copy+number+amplification+in+uterine+leiomyomas+using+the+100K+single+nucleotide+polymorphism+array.&rft.au=Meadows%2C+Kellen+L%3BAndrews%2C+Danica+M+K%3BXu%2C+Zongli%3BCarswell%2C+Gleta+K%3BLaughlin%2C+Shannon+K%3BBaird%2C+Donna+D%3BTaylor%2C+Jack+A&rft.aulast=Meadows&rft.aufirst=Kellen&rft.date=2011-08-01&rft.volume=91&rft.issue=1&rft.spage=434&rft.isbn=&rft.btitle=&rft.title=Experimental+and+molecular+pathology&rft.issn=1096-0945&rft_id=info:doi/10.1016%2Fj.yexmp.2011.03.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-13 N1 - Date created - 2011-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Occup Environ Med. 2007 May;49(5):493-506 [17495692] Obstet Gynecol. 2006 Oct;108(4):930-7 [17012456] Cancer Genet Cytogenet. 1999 Oct 15;114(2):89-95 [10549262] Mol Hum Reprod. 1999 Dec;5(12):1150-4 [10587370] Genes Chromosomes Cancer. 2000 Jul;28(3):235-45 [10862029] Cancer Genet Cytogenet. 2000 Aug;121(1):1-8 [10958933] Nat Biotechnol. 2000 Sep;18(9):1001-5 [10973224] Lancet. 2001 Jan 27;357(9252):293-8 [11214143] Am J Obstet Gynecol. 2003 Jan;188(1):100-7 [12548202] Environ Health Perspect. 2003 Jun;111(8):1037-54 [12826476] Eur J Obstet Gynecol Reprod Biol. 2003 Sep 10;110(1):58-62 [12932873] Cancer Res. 2003 Aug 15;63(16):4781-5 [12941794] Cancer Res. 2004 May 1;64(9):3060-71 [15126342] Mol Carcinog. 1997 Aug;19(4):273-9 [9290705] Mol Hum Reprod. 1998 Jan;4(1):83-6 [9510016] Mol Carcinog. 1998 Dec;23(4):243-7 [9869453] Nature. 1998 Dec 17;396(6712):643-9 [9872311] Hum Genomics. 2004 May;1(4):287-99 [15588488] Mol Carcinog. 2005 Mar;42(3):177-82 [15605361] Cancer Genet Cytogenet. 2005 Apr 1;158(1):1-26 [15771900] Bioinformatics. 2005 May 1;21(9):1958-63 [15657097] Science. 2005 Jun 10;308(5728):1589-92 [15947177] Oncogene. 2005 Sep 29;24(43):6545-54 [15940248] PLoS Comput Biol. 2006 May;2(5):e41 [16699594] Am J Obstet Gynecol. 2006 Oct;195(4):955-64 [16723104] J Womens Health (Larchmt). 2009 May;18(5):725-32 [19366341] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.yexmp.2011.03.007 ER - TY - JOUR T1 - The almighty MYC: orchestrating the micro-RNA universe to generate aggressive liver cancer. AN - 878034084; 21349304 JF - Journal of hepatology AU - Thorgeirsson, Snorri S AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. snorri_thorgeirsson@nih.gov Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 486 EP - 487 VL - 55 IS - 2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878034084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hepatology&rft.atitle=The+almighty+MYC%3A+orchestrating+the+micro-RNA+universe+to+generate+aggressive+liver+cancer.&rft.au=Thorgeirsson%2C+Snorri+S&rft.aulast=Thorgeirsson&rft.aufirst=Snorri&rft.date=2011-08-01&rft.volume=55&rft.issue=2&rft.spage=486&rft.isbn=&rft.btitle=&rft.title=Journal+of+hepatology&rft.issn=1600-0641&rft_id=info:doi/10.1016%2Fj.jhep.2011.01.042 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-21 N1 - Date created - 2011-07-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20471-6 [21059911] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jhep.2011.01.042 ER - TY - JOUR T1 - Voluntary exercise protects hippocampal neurons from trimethyltin injury: possible role of interleukin-6 to modulate tumor necrosis factor receptor-mediated neurotoxicity. AN - 878030607; 21435392 AB - In the periphery, exercise induces interleukin (IL)-6 to downregulate tumor necrosis factor (TNF), elevate interleukin-1 receptor antagonist (IL-1RA), decreasing inflammation. Exercise also offers neuroprotection and facilitates brain repair. IL-6 production in the hippocampus following exercise suggests the potential of a similar protective role as in the periphery to down-regulate TNFα and inflammation. Using a chemical-induced model of hippocampal dentate granule cell death (trimethyltin, TMT 2.4 mg/kg, ip) dependent upon TNF receptor signaling, we demonstrate neuroprotection in mice with 2 weeks access to running wheel. Exercise attenuated neuronal death and diminished elevations in TNFα, TNF receptor 1, myeloid differentiation primary response gene (MyD) 88, transforming growth factor β, chemokine (C-C motif) ligand 2 (CCL2), and CCL3. Elevated mRNA levels for IL-1α, IL-1RA, occurred with injury and protection. mRNA and protein levels of IL-6 and neuronal expression of IL-6 receptor α, were elevated with injury and protection. Microarray pathway analysis supported an up-regulation of TNFα cell death signaling pathways with TMT and inhibition by exercise. IL-6 pathway recruitment occurred in both conditions. IL-6 downstream signal events differed in the level of STAT3 activation. Exercise did not increase mRNA levels of brain derived neurotrophic factor, nerve growth factor, or glial derived neurotrophic factor. In IL-6 deficient mice, exercise did not attenuate TMT-induced tremor and a diminished level of neuroprotection was observed. These data suggest a contributory role for IL-6 induced by exercise for neuroprotection in the CNS similar to that seen in the periphery. Published by Elsevier Inc. JF - Brain, behavior, and immunity AU - Funk, Jason A AU - Gohlke, Julia AU - Kraft, Andrew D AU - McPherson, Christopher A AU - Collins, Jennifer B AU - Jean Harry, G AD - Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, United States. Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 1063 EP - 1077 VL - 25 IS - 6 KW - Chemokines KW - 0 KW - Interleukin-6 KW - Myd88 protein, mouse KW - Myeloid Differentiation Factor 88 KW - Nerve Tissue Proteins KW - Neurotoxins KW - RNA, Messenger KW - Receptors, Tumor Necrosis Factor KW - Trimethyltin Compounds KW - Tumor Necrosis Factor-alpha KW - trimethyltin hydroxide KW - 56-24-6 KW - Index Medicus KW - Specific Pathogen-Free Organisms KW - Animals KW - Chemokines -- genetics KW - Random Allocation KW - Chemokines -- biosynthesis KW - Tumor Necrosis Factor-alpha -- physiology KW - Mice KW - Nerve Tissue Proteins -- biosynthesis KW - RNA, Messenger -- genetics KW - Nerve Tissue Proteins -- genetics KW - Tremor -- chemically induced KW - RNA, Messenger -- biosynthesis KW - Mice, Knockout KW - Epilepsy, Tonic-Clonic -- chemically induced KW - Myeloid Differentiation Factor 88 -- biosynthesis KW - Mice, Inbred C57BL KW - Myeloid Differentiation Factor 88 -- genetics KW - Up-Regulation KW - Models, Neurological KW - Radiation Chimera KW - Male KW - Neurons -- metabolism KW - Neurons -- drug effects KW - Hippocampus -- metabolism KW - Interleukin-6 -- deficiency KW - Receptors, Tumor Necrosis Factor -- drug effects KW - Trimethyltin Compounds -- toxicity KW - Neurotoxins -- toxicity KW - Hippocampus -- drug effects KW - Neurons -- pathology KW - Interleukin-6 -- physiology KW - Receptors, Tumor Necrosis Factor -- biosynthesis KW - Physical Conditioning, Animal -- physiology KW - Receptors, Tumor Necrosis Factor -- physiology KW - Interleukin-6 -- genetics KW - Hippocampus -- pathology KW - Interleukin-6 -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878030607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain%2C+behavior%2C+and+immunity&rft.atitle=Voluntary+exercise+protects+hippocampal+neurons+from+trimethyltin+injury%3A+possible+role+of+interleukin-6+to+modulate+tumor+necrosis+factor+receptor-mediated+neurotoxicity.&rft.au=Funk%2C+Jason+A%3BGohlke%2C+Julia%3BKraft%2C+Andrew+D%3BMcPherson%2C+Christopher+A%3BCollins%2C+Jennifer+B%3BJean+Harry%2C+G&rft.aulast=Funk&rft.aufirst=Jason&rft.date=2011-08-01&rft.volume=25&rft.issue=6&rft.spage=1063&rft.isbn=&rft.btitle=&rft.title=Brain%2C+behavior%2C+and+immunity&rft.issn=1090-2139&rft_id=info:doi/10.1016%2Fj.bbi.2011.03.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-07 N1 - Date created - 2011-07-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Sci. 2009 Aug;110(4):424-36 [19602844] J Neuroendocrinol. 2010 Aug;22(8):872-88 [20406350] Acta Physiol (Oxf). 2011 Apr;201(4):475-82 [21083649] Bioinformatics. 2006 May 1;22(9):1111-21 [16522673] Neurosci Lett. 2006 May 15;399(1-2):162-6 [16504399] Annu Rev Immunol. 2000;18:621-63 [10837071] Oncogene. 2000 May 15;19(21):2468-73 [10851045] J Physiol. 2000 Oct 1;528 Pt 1:157-63 [11018114] Glia. 2000 Dec;32(3):271-85 [11102968] Brain Res. 2001 Mar 30;896(1-2):86-95 [11277977] Int J Sports Med. 2001 May;22(4):261-7 [11414667] Mol Cell Biol. 2001 Aug;21(16):5299-305 [11463813] Brain Res. 2001 Sep 7;912(2):116-27 [11532427] Exp Neurol. 2002 May;175(1):152-60 [12009767] Toxicol Appl Pharmacol. 2002 May 1;180(3):205-18 [12009860] J Physiol. 2002 Aug 1;542(Pt 3):991-5 [12154196] Oncogene. 2002 Dec 12;21(57):8769-75 [12483530] Mol Cell Neurosci. 2002 Nov;21(3):379-92 [12498781] J Neurosci Res. 2003 Feb 15;71(4):583-90 [12548715] J Neuropathol Exp Neurol. 2003 Mar;62(3):315-28 [12638735] FASEB J. 2003 May;17(8):884-6 [12626436] Exp Neurol. 2003 Jun;181(2):130-48 [12781987] J Neurosci Res. 2003 Aug 15;73(4):526-36 [12898537] J Neurosci. 2004 May 5;24(18):4432-43 [15128857] Mol Pharmacol. 1992 Jul;42(1):44-56 [1635553] Blood. 1994 Jan 1;83(1):113-8 [8274730] J Exp Med. 1994 May 1;179(5):1529-37 [8163936] Science. 1994 Jun 3;264(5164):1415-21 [8197455] Infect Immun. 1995 Apr;63(4):1158-64 [7890366] Nature. 1995 Jul 13;376(6536):167-70 [7603567] Genomics. 1995 Sep 20;29(2):490-5 [8666399] Cell. 1996 Feb 9;84(3):331-4 [8608586] J Exp Med. 1996 Jun 1;183(6):2627-34 [8676083] EMBO J. 1996 Jul 15;15(14):3651-8 [8670868] Cell Tissue Res. 1997 Feb;287(3):447-58 [9023076] Immunity. 1997 Dec;7(6):837-47 [9430229] Glia. 1998 Feb;22(2):180-8 [9537838] J Neurochem. 1998 Oct;71(4):1577-87 [9751191] Biochem J. 1999 Jan 1;337 ( Pt 1):59-65 [9854025] J Neurosci. 1999 Jun 1;19(11):4305-13 [10341234] Genes Dev. 1999 Oct 1;13(19):2604-16 [10521404] Cancer Res. 2005 Feb 1;65(3):939-47 [15705894] Exp Brain Res. 2005 Sep;165(4):520-31 [15991029] J Neurosci. 2005 Sep 21;25(38):8680-5 [16177036] Gene Expr. 2006;13(1):41-52 [16572589] J Cell Biochem. 2006 May 15;98(2):243-50 [16453279] Ann N Y Acad Sci. 2006 Jul;1070:450-6 [16888208] Sci STKE. 2006 Oct 17;2006(357):re13 [17047224] Curr Neurovasc Res. 2006 Nov;3(4):263-71 [17109621] Brain Res. 2007 Feb 2;1131(1):17-28 [17161388] J Physiol Pharmacol. 2006 Nov;57 Suppl 10:43-51 [17242490] Nat Rev Neurosci. 2007 Mar;8(3):221-32 [17311007] Curr Opin Clin Nutr Metab Care. 2007 May;10(3):265-71 [17414493] Genes Dev. 2007 Jun 1;21(11):1396-408 [17510282] J Neurosci. 2007 Jun 20;27(25):6633-46 [17581950] Trends Cogn Sci. 2007 Aug;11(8):342-8 [17629545] Neuroendocrinology. 2007;86(1):26-37 [17595533] Cytokine Growth Factor Rev. 2007 Oct-Dec;18(5-6):511-8 [17683973] Prog Brain Res. 2007;163:355-70 [17765729] Trends Neurosci. 2007 Sep;30(9):464-72 [17765329] Curr Med Chem. 2007;14(24):2564-71 [17979709] Mol Cell Neurosci. 2008 Jan;37(1):110-8 [17933551] Neurochem Int. 2008 Mar-Apr;52(4-5):761-9 [17949856] Neurobiol Dis. 2008 Apr;30(1):121-9 [18258444] J Neuroinflammation. 2008;5:13 [18400101] J Neurochem. 2008 Jul;106(1):281-98 [18373618] Comment In: Brain Behav Immun. 2011 Aug;25(6):1061-2 [21640182] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbi.2011.03.012 ER - TY - JOUR T1 - A novel nitroxide is an effective brain redox imaging contrast agent and in vivo radioprotector. AN - 874897855; 21664459 AB - Individuals are exposed to ionizing radiation during medical procedures and nuclear disasters, and this exposure can be carcinogenic, toxic, and sometimes fatal. Drugs that protect individuals from the adverse effects of radiation may therefore be valuable countermeasures against the health risks of exposure. In the current study, the LD(50/30) (the dose resulting in 50% of exposed mice surviving 30 days after exposure) was determined in control C3H mice and mice treated with the nitroxide radioprotectors Tempol, 3-CP, 16c, 22c, and 23c. The pharmacokinetics of 22c and 23c were measured with magnetic resonance imaging (MRI) in the brain, blood, submandibular salivary gland, liver, muscle, tongue, and myocardium. It was found that 23c was the most effective radioprotector of the five studied: 23c increased the LD(50/30) in mice from 7.9±0.15Gy (treated with saline) to 11.47±0.13Gy (an increase of 45%). Additionally, MRI-based pharmacokinetic studies revealed that 23c is an effective redox imaging agent in the mouse brain, and that 23c may allow functional imaging of the myocardium. The data in this report suggest that 23c is currently the most potent known nitroxide radioprotector, and that it may also be useful as a contrast agent for functional imaging. Published by Elsevier Inc. JF - Free radical biology & medicine AU - Davis, Ryan M AU - Sowers, Anastasia L AU - DeGraff, William AU - Bernardo, Marcelino AU - Thetford, Angela AU - Krishna, Murali C AU - Mitchell, James B AD - Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. ryan.m.davis@duke.edu Y1 - 2011/08/01/ PY - 2011 DA - 2011 Aug 01 SP - 780 EP - 790 VL - 51 IS - 3 KW - Contrast Media KW - 0 KW - Cyclic N-Oxides KW - Radiation-Protective Agents KW - Spin Labels KW - Nitric Oxide KW - 31C4KY9ESH KW - tempol KW - U78ZX2F65X KW - Index Medicus KW - Oxidation-Reduction KW - Magnetic Resonance Imaging KW - Animals KW - Radiation Injuries -- prevention & control KW - Mice, Inbred C3H KW - Mice KW - Radiography KW - Radiation, Ionizing KW - Radiation Injuries -- etiology KW - Contrast Media -- pharmacokinetics KW - Radiation-Protective Agents -- chemistry KW - Radiation-Protective Agents -- administration & dosage KW - Radiation-Protective Agents -- pharmacokinetics KW - Nitric Oxide -- pharmacokinetics KW - Contrast Media -- chemistry KW - Brain -- radiation effects KW - Nitric Oxide -- chemistry KW - Contrast Media -- administration & dosage KW - Brain -- diagnostic imaging KW - Nitric Oxide -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874897855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=A+novel+nitroxide+is+an+effective+brain+redox+imaging+contrast+agent+and+in+vivo+radioprotector.&rft.au=Davis%2C+Ryan+M%3BSowers%2C+Anastasia+L%3BDeGraff%2C+William%3BBernardo%2C+Marcelino%3BThetford%2C+Angela%3BKrishna%2C+Murali+C%3BMitchell%2C+James+B&rft.aulast=Davis&rft.aufirst=Ryan&rft.date=2011-08-01&rft.volume=51&rft.issue=3&rft.spage=780&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=1873-4596&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2011.05.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-05 N1 - Date created - 2011-07-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuroreport. 1998 Aug 24;9(12):2853-6 [9760133] J Med Chem. 1998 Aug 27;41(18):3477-92 [9719601] Neuropharmacology. 1999 Feb;38(2):307-14 [10218873] Clin Cancer Res. 2005 Oct 15;11(20):7564-8 [16243832] Spectrochim Acta A Mol Biomol Spectrosc. 2006 Mar 13;63(4):840-5 [16543118] Clin Cancer Res. 2006 Apr 15;12(8):2455-62 [16638852] Cancer Res. 2006 Oct 15;66(20):9921-8 [17047054] Int J Radiat Oncol Biol Phys. 2007 Mar 15;67(4):1059-65 [17241755] J Inherit Metab Dis. 2007 Jun;30(3):318-25 [17457692] Clin Cancer Res. 2007 Aug 15;13(16):4928-33 [17699873] J Cereb Blood Flow Metab. 2008 Jun;28(6):1165-74 [18270519] J Pharm Pharmacol. 2008 Aug;60(8):1049-60 [18644197] Lancet Neurol. 2009 Sep;8(9):810-8 [19665931] Free Radic Res. 2009 Sep;43(9):844-51 [19629818] J Neurosci Res. 2010 Mar;88(4):905-16 [19798748] Neuropharmacology. 2010 Mar-Apr;58(4-5):739-45 [20036264] Ann Intern Med. 2010 Apr 6;152(7):444-55; W144-54 [20368650] Laryngoscope. 2010 Jul;120(7):1336-41 [20564718] Free Radic Biol Med. 2011 Feb 1;50(3):459-68 [21130158] Disaster Med Public Health Prep. 2011 Mar;5 Suppl 1:S32-44 [21402810] Anticancer Agents Med Chem. 2011 May 1;11(4):347-58 [21434855] Eur J Pharmacol. 1999 Dec 3;385(2-3):103-10 [10607865] Int J Radiat Oncol Biol Phys. 2000 Oct 1;48(3):635-42 [11020558] Cancer Res. 2002 Jan 1;62(1):307-12 [11782393] Mol Cell Biochem. 2002 May-Jun;234-235(1-2):369-77 [12162455] Mol Cell Biochem. 2002 May-Jun;234-235(1-2):393-8 [12162459] Acta Radiol. 2002 Jul;43(4):433-40 [12225490] Lancet. 2002 Nov 2;360(9343):1361-8 [12423981] Nutr Neurosci. 2002 Dec;5(6):407-16 [12509070] Free Radic Biol Med. 2003 Jul 1;35(1):59-67 [12826256] Endocrinology. 2003 Sep;144(9):4117-22 [12933686] Free Radic Biol Med. 2003 Dec 15;35(12):1619-31 [14680685] Antioxid Redox Signal. 2004 Jun;6(3):587-95 [15130285] J Nucl Med. 2004 Aug;45(8):1398-405 [15299067] Int J Radiat Oncol Biol Phys. 1988 Apr;14(4):811-5 [3350733] Free Radic Biol Med. 1988;5(1):7-11 [2855418] Arch Biochem Biophys. 1991 Aug 15;289(1):62-70 [1654848] Cancer Res. 1992 Apr 1;52(7):1750-3 [1551104] Cancer. 1994 Nov 15;74(10):2828-35 [7954244] Free Radic Res. 1995 Mar;22(3):209-14 [7757197] Free Radic Biol Med. 1997;22(7):1211-6 [9098095] Br J Pharmacol. 1997 Jun;121(4):827-33 [9208155] Free Radic Biol Med. 1997;23(4):533-40 [9215798] Diabetologia. 1998 Nov;41(11):1355-60 [9833944] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2011.05.019 ER - TY - JOUR T1 - Extranuclear signaling of mutated thyroid hormone receptors in promoting metastatic spread in thyroid carcinogenesis. AN - 874894452; 21473875 AB - Thyroid hormone receptors (TRs) mediate the critical activities of the thyroid hormone (T3) in growth, development, and differentiation. Decreased expression and/or somatic mutations of TRs have been shown to be associated with several types of human cancers including liver, breast, lung, and thyroid. A direct demonstration that TRβ mutants could function as oncogenes is evidenced by the spontaneous development of follicular thyroid carcinoma similar to human cancer in a knockin mouse model harboring a mutated TRβ (denoted as PV; Thrb(PV/PV) mice). PV is a dominant negative mutation identified in a patient with resistance to thyroid hormone. Analysis of altered gene expression and molecular studies of thyroid carcinogenesis in Thrb(PV/PV) mice show that the oncogenic activity of PV is mediated by both nucleus-initiated transcription and extranuclear actions to alter gene expression and signaling transduction activity. This article focuses on recent findings of novel extranuclear actions of PV that affect signaling cascades and thereby the invasiveness, migration, and motility of thyroid tumor cells. These findings have led to identification of potential molecular targets for treatment of metastatic thyroid cancer. Published by Elsevier Inc. JF - Steroids AU - Lu, Changxue AU - Cheng, Sheue-Yann AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA. Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 885 EP - 891 VL - 76 IS - 9 KW - Cell Adhesion Molecules KW - 0 KW - Mutant Proteins KW - Thyroid Hormone Receptors beta KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Frameshift Mutation KW - Cell Movement KW - Neoplasm Invasiveness KW - Animals KW - Extracellular Matrix -- metabolism KW - Mitogen-Activated Protein Kinases -- metabolism KW - Humans KW - Cell Adhesion Molecules -- metabolism KW - Thyroid Hormone Receptors beta -- metabolism KW - Mutant Proteins -- genetics KW - Thyroid Neoplasms -- genetics KW - Thyroid Neoplasms -- metabolism KW - Mutant Proteins -- metabolism KW - Thyroid Hormone Receptors beta -- genetics KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874894452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Steroids&rft.atitle=Extranuclear+signaling+of+mutated+thyroid+hormone+receptors+in+promoting+metastatic+spread+in+thyroid+carcinogenesis.&rft.au=Lu%2C+Changxue%3BCheng%2C+Sheue-Yann&rft.aulast=Lu&rft.aufirst=Changxue&rft.date=2011-08-01&rft.volume=76&rft.issue=9&rft.spage=885&rft.isbn=&rft.btitle=&rft.title=Steroids&rft.issn=1878-5867&rft_id=info:doi/10.1016%2Fj.steroids.2011.03.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-25 N1 - Date created - 2011-07-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Endocrinol Metab. 2002 Mar;87(3):1120-8 [11889175] Carcinogenesis. 2002 Jan;23(1):25-33 [11756220] Pathol Int. 2002 Jul;52(7):438-41 [12167101] J Endocrinol. 2002 Dec;175(3):553-70 [12475367] Thyroid. 2002 Nov;12(11):963-9 [12490073] Cancer Metastasis Rev. 2003 Dec;22(4):395-403 [12884914] Nat Med. 2004 Feb;10(2):175-81 [14704789] Mol Cell Endocrinol. 2003 Dec 31;213(1):1-11 [15062569] J Biol Chem. 1990 Oct 25;265(30):18546-53 [2170415] J Clin Invest. 1991 Dec;88(6):2123-30 [1661299] Mol Cell Biol. 1996 Oct;16(10):5623-33 [8816475] Anticancer Res. 1998 Jan-Feb;18(1A):33-40 [9568052] Mol Carcinog. 1999 Sep;26(1):53-61 [10487522] Mol Cancer Res. 2004 Nov;2(11):595-605 [15561776] Nat Rev Mol Cell Biol. 2005 Jan;6(1):56-68 [15688067] Endocrinology. 2005 Jul;146(7):2864-71 [15802494] Cancer Genet Cytogenet. 2005 Sep;161(2):104-9 [16102579] Endocrinology. 2005 Oct;146(10):4456-63 [16002527] Thyroid. 2005 Sep;15(9):1011-20 [16187909] Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1780-5 [16446424] Oncogene. 2006 May 4;25(19):2736-47 [16314832] J Clin Invest. 2006 Nov;116(11):2972-84 [17039256] J Biol Chem. 2007 Aug 3;282(31):22964-76 [17562714] Exp Cell Res. 2007 Sep 10;313(15):3175-88 [17651734] Carcinogenesis. 2007 Dec;28(12):2451-8 [17660507] Cancer Res. 2008 Mar 15;68(6):1935-44 [18339875] J Biol Chem. 2008 May 9;283(19):12898-908 [18353785] Steroids. 2008 Oct;73(9-10):1008-12 [18280526] Mol Cell Biol. 2008 Jul;28(14):4598-608 [18474620] Curr Opin Pharmacol. 2008 Aug;8(4):427-32 [18625340] Lung Cancer. 2009 Apr;64(1):13-21 [18771813] Breast Cancer Res. 2009;11(1):R5 [19173736] J Clin Endocrinol Metab. 2009 Jun;94(6):2199-203 [19293266] Cancer Res. 2009 Nov 1;69(21):8217-22 [19843848] J Cell Physiol. 2010 Jan;222(1):1-10 [19688773] Am J Physiol Endocrinol Metab. 2009 Dec;297(6):E1238-46 [19755667] Endocrinology. 2010 Apr;151(4):1929-39 [20133453] Endocr Rev. 2010 Apr;31(2):139-70 [20051527] Carcinogenesis. 2010 Jul;31(7):1284-91 [20299527] J Endod. 2010 Aug;36(8):1332-5 [20647091] Expert Opin Investig Drugs. 2010 Oct;19(10):1205-16 [20687784] Cell Signal. 2011 Jan;23(1):125-34 [20816750] Nature. 2010 Nov 25;468(7323):580-4 [21107430] Anticancer Res. 2010 Nov;30(11):4485-92 [21115897] Annu Rev Pharmacol Toxicol. 2011;51:99-115 [20868274] J Cell Physiol. 2011 Jul;226(7):1850-9 [21506116] Biochem Soc Trans. 2000;28(4):311-39 [10961914] Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14 [11069286] J Clin Endocrinol Metab. 2001 Nov;86(11):5572-6 [11701737] Rev Endocr Metab Disord. 2000 Jan;1(1-2):9-18 [11704997] Rev Endocr Metab Disord. 2000 Jan;1(1-2):97-108 [11704998] J Biol Chem. 2002 Jun 14;277(24):21352-60 [11929865] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.steroids.2011.03.016 ER - TY - JOUR T1 - Normative Beliefs and Sexual Risk in China AN - 874179524; 20960047 AB - We examined normative beliefs about multiple sexual partners and social status in China and their association with risky sexual behaviors and sexually transmitted infections (STIs). Self-reported and biological markers of sexual risk were examined among 3,716 market vendors from a city in eastern China. Men who were older or with less education believed having multiple sexual partners was linked to higher social status. Adjusting for demographic characteristics, normative beliefs were significantly associated with having multiple sexual partners, while having multiple sexual partners was significantly associated with STIs. Normative beliefs regarding sexual behaviors may play an important role in individual risk behaviors. Future HIV/STI interventions must address community beliefs about the positive meaning of sexual risks, particularly among men with traditional beliefs about gender roles.[PUBLICATION ABSTRACT] JF - AIDS and Behavior AU - Li, Li AU - Ding, Ying Ying AU - Wu, Zunyou AU - Rotheram-borus, Mary Jane AU - Guo, Sam Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 1251 EP - 8 CY - New York PB - Springer Science & Business Media VL - 15 IS - 6 SN - 10907165 KW - Psychology KW - Sexual behavior KW - Health behavior KW - Sexually transmitted diseases--STD KW - Sex roles KW - Belief & doubt KW - China KW - Socioeconomic Factors KW - Young Adult KW - Culture KW - Questionnaires KW - Risk-Taking KW - Social Class KW - Risk Factors KW - Humans KW - Adult KW - Sexual Behavior -- ethnology KW - Middle Aged KW - Sexually Transmitted Diseases -- prevention & control KW - Male KW - Female KW - Gender Identity KW - Sexual Partners -- psychology KW - Sexual Behavior -- psychology KW - Sexually Transmitted Diseases -- transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874179524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acriminaljusticeperiodicals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Normative+Beliefs+and+Sexual+Risk+in+China&rft.au=Li%2C+Li%3BDing%2C+Ying+Ying%3BWu%2C+Zunyou%3BRotheram-borus%2C+Mary+Jane%3BGuo%2C+Sam&rft.aulast=Li&rft.aufirst=Li&rft.date=2011-08-01&rft.volume=15&rft.issue=6&rft.spage=1251&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-010-9835-4 LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2011 N1 - Last updated - 2014-08-30 N1 - CODEN - AIBEFC N1 - SubjectsTermNotLitGenreText - China DO - http://dx.doi.org/10.1007/s10461-010-9835-4 ER - TY - JOUR T1 - Employment and Physical Activity in the U.S AN - 1823507468; 201120951 AB - Cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) were collected in 2003-2004 and analyzed in 2010. Physical activity was measured using Actigraph uniaxial accelerometers, and participants aged 20-60 years with =4 days of monitoring were included (N=1826). Accelerometer variables included mean counts/minute during wear time and proportion of wear time spent in various intensity levels. Results: In men, full-time workers were more active than healthy nonworkers (p=0.004), and in weekday-only analyses, even workers with sedentary jobs were more active (p=0.03) and spent less time sedentary (p0.001) than nonworkers. In contrast with men, women with full-time sedentary jobs spent more time sedentary (p=0.008) and had less light and lifestyle intensity activity than healthy nonworkers on weekdays. Within full-time workers, those with active jobs had greater weekday activity than those with sedentary jobs (22% greater in men, 30% greater in women). Conclusions: In men, full-time employment, even in sedentary occupations, is positively associated with physical activity compared to not working, and in both genders job type has a major bearing on daily activity levels. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Van Domelen, Dane R AU - Koster, Annemarie AU - Caserotti, Paolo AU - Brychta, Robert J AU - Chen, Kong Y AU - McClain, James J AU - Troiano, Richard P AU - Berrigan, David AU - Harris, Tamara B AD - Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 136 EP - 145 PB - Elsevier Science, New York NY VL - 41 IS - 2 SN - 0749-3797, 0749-3797 KW - Men KW - Sedentary KW - Physical activity KW - Employment KW - Activities of daily living KW - Lifestyle KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1823507468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Employment+and+Physical+Activity+in+the+U.S&rft.au=Van+Domelen%2C+Dane+R%3BKoster%2C+Annemarie%3BCaserotti%2C+Paolo%3BBrychta%2C+Robert+J%3BChen%2C+Kong+Y%3BMcClain%2C+James+J%3BTroiano%2C+Richard+P%3BBerrigan%2C+David%3BHarris%2C+Tamara+B&rft.aulast=Van+Domelen&rft.aufirst=Dane&rft.date=2011-08-01&rft.volume=41&rft.issue=2&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2011.03.019 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Sedentary; Physical activity; Men; Employment; Activities of daily living; Lifestyle DO - http://dx.doi.org/10.1016/j.amepre.2011.03.019 ER - TY - JOUR T1 - Automatic saw-mark detection in multicrystalline solar wafer images AN - 1701067013; 15113581 AB - This paper presents a method of automatic defect inspection for the photovoltaic industry, with a special focus on multicrystalline solar wafers. It presents a machine vision-based scheme to automatically detect saw-mark defects in solar wafer surfaces. A saw-mark defect is a severe flaw that occurs when a silicon ingot is cut into wafers. Early detection of saw-mark defects in the wafer cutting process can reduce material waste and improve production yields. A multicrystalline solar wafer surface presents random shapes, sizes, and orientations of crystal grains in the surface, making the automatic detection of saw-mark defects extremely difficult. The proposed saw-mark detection scheme involves two main procedures: (1) Fourier image reconstruction to remove the multi-grain background of a solar wafer image and (2) a line detection process in the reconstructed image to locate saw-marks. The Fourier transform (FT) is used to eliminate crystal grain patterns and results in a non-textured surface in the reconstructed image. Since a saw-mark is presented horizontally in the sliced wafer, vertical scan lines in the reconstructed image are individually evaluated by a line detection process. A pixel far away from the line sought can then be effectively identified as a defect point. Experimental results show that the proposed method can effectively detect various saw-mark defects, specifically black lines, white lines, and impurities in multicrystalline solar wafers. JF - Solar Energy Materials and Solar Cells AU - Li, Wei-Chen AU - Tsai, Du-Ming AD - Department of Industrial Engineering and Management, Yuan-Ze University, 135 Yuan-Tung Road, Nei-Li, Tao-Yuan, Taiwan 32003, R.O.C. Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 2206 EP - 2220 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 95 IS - 8 SN - 0927-0248, 0927-0248 KW - Solid State and Superconductivity Abstracts (SO); Mechanical & Transportation Engineering Abstracts (MT); Environmental Engineering Abstracts (EN); Electronics and Communications Abstracts (EA) KW - Surface inspection KW - Defect detection KW - Multicrystalline silicon KW - Solar wafer KW - Saw-mark KW - Fourier transform KW - Wafers KW - Solar cells KW - A defects KW - Images KW - Grains KW - Ingots KW - Crystal defects KW - Photovoltaic cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701067013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Solar+Energy+Materials+and+Solar+Cells&rft.atitle=Automatic+saw-mark+detection+in+multicrystalline+solar+wafer+images&rft.au=Li%2C+Wei-Chen%3BTsai%2C+Du-Ming&rft.aulast=Li&rft.aufirst=Wei-Chen&rft.date=2011-08-01&rft.volume=95&rft.issue=8&rft.spage=2206&rft.isbn=&rft.btitle=&rft.title=Solar+Energy+Materials+and+Solar+Cells&rft.issn=09270248&rft_id=info:doi/10.1016%2Fj.solmat.2011.03.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1016/j.solmat.2011.03.025 ER - TY - JOUR T1 - The Complexity of the Dirichlet Model for Multiple Alignment Data AN - 1622614881; 20886457 AB - A model is a set of possible theories for describing a set of data. When the data are used to select a maximum-likelihood theory, an important question is how many effectively independent theories the model contains; the log of this number is called the model's complexity. The Dirichlet model is the set of all Dirichlet distributions, which are probability densities over the space of multinomials. A Dirichlet distribution may be used to describe multiple-alignment data, consisting of n columns of letters, with c letters in each column. We here derive, in the limit of large n and c, a closed-form expression for the complexity of the Dirichlet model applied to such data. For small c, we derive as well a minor correction to this formula, which is easily calculated by Monte Carlo simulation. Although our results are confined to the Dirichlet model, they may cast light as well on the complexity of Dirichlet mixture models, which have been applied fruitfully to the study of protein multiple sequence alignments. JF - Journal of Computational Biology AU - Yu, Yi-Kuo AU - Altschul, Stephen F AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland PY - 2011 SP - 925 EP - 939 PB - Mary Ann Liebert, Inc., 2 Madison Ave Larchmont NY 10538 United States VL - 18 IS - 8 SN - 1557-8666, 1557-8666 KW - Biotechnology and Bioengineering Abstracts KW - alignment KW - computational molecular biology KW - dynamic programming KW - multiple alignment KW - sequence analysis KW - Monte Carlo simulation KW - Data processing KW - Nucleotide sequence KW - Computer applications KW - Models KW - Amino acid sequence KW - Light effects KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622614881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Computational+Biology&rft.atitle=The+Complexity+of+the+Dirichlet+Model+for+Multiple+Alignment+Data&rft.au=Yu%2C+Yi-Kuo%3BAltschul%2C+Stephen+F&rft.aulast=Yu&rft.aufirst=Yi-Kuo&rft.date=2011-08-01&rft.volume=18&rft.issue=8&rft.spage=925&rft.isbn=&rft.btitle=&rft.title=Journal+of+Computational+Biology&rft.issn=15578666&rft_id=info:doi/10.1089%2Fcmb.2011.0039 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Monte Carlo simulation; Data processing; Nucleotide sequence; Computer applications; Light effects; Amino acid sequence; Models DO - http://dx.doi.org/10.1089/cmb.2011.0039 ER - TY - JOUR T1 - On the Inference of Dirichlet Mixture Priors for Protein Sequence Comparison AN - 1622600970; 20886458 AB - Dirichlet mixtures provide an elegant formalism for constructing and evaluating protein multiple sequence alignments. Their use requires the inference of Dirichlet mixture priors from curated sets of accurately aligned sequences. This article addresses two questions relevant to such inference: of how many components should a Dirichlet mixture consist, and how may a maximum-likelihood mixture be derived from a given data set. To apply the Minimum Description Length principle to the first question, we extend an analytic formula for the complexity of a Dirichlet model to Dirichlet mixtures by informal argument. We apply a Gibbs-sampling based approach to the second question. Using artificial data generated by a Dirichlet mixture, we demonstrate that our methods are able to approximate well the true theory, when it exists. We apply our methods as well to real data, and infer Dirichlet mixtures that describe the data better than does a mixture derived using previous approaches. JF - Journal of Computational Biology AU - Ye, Xugang AU - Yu, Yi-Kuo AU - Altschul, Stephen F AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland PY - 2011 SP - 941 EP - 954 PB - Mary Ann Liebert, Inc., 2 Madison Ave Larchmont NY 10538 United States VL - 18 IS - 8 SN - 1557-8666, 1557-8666 KW - Biotechnology and Bioengineering Abstracts KW - algorithms KW - combinatorics KW - linear programming KW - machine learning KW - statistics KW - Data processing KW - Nucleotide sequence KW - Computer applications KW - Amino acid sequence KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622600970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Computational+Biology&rft.atitle=On+the+Inference+of+Dirichlet+Mixture+Priors+for+Protein+Sequence+Comparison&rft.au=Ye%2C+Xugang%3BYu%2C+Yi-Kuo%3BAltschul%2C+Stephen+F&rft.aulast=Ye&rft.aufirst=Xugang&rft.date=2011-08-01&rft.volume=18&rft.issue=8&rft.spage=941&rft.isbn=&rft.btitle=&rft.title=Journal+of+Computational+Biology&rft.issn=15578666&rft_id=info:doi/10.1089%2Fcmb.2011.0040 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Data processing; Nucleotide sequence; Computer applications; Models; Amino acid sequence DO - http://dx.doi.org/10.1089/cmb.2011.0040 ER - TY - JOUR T1 - The case for peripheral CB1 receptor blockade in the treatment of visceral obesity and its cardiometabolic complications AN - 1427004711; 16704449 AB - Keywords: diet-induced obesity; metabolic syndrome; endocannabinoids; anandamide; 2-arachidonoylglycerol; peripheral CB1 receptors In this review, we consider the role of endocannabinoids and cannabinoid-1 (CB1) cannabinoid receptors in metabolic regulation and as mediators of the thrifty phenotype that underlies the metabolic syndrome. We survey the actions of endocannabinoids on food intake and body weight, as well as on the metabolic complications of visceral obesity, including fatty liver, insulin resistance and dyslipidemias. Special emphasis is placed on weighing the relative importance of CB1 receptors located in peripheral tissues versus the central nervous system in mediating the metabolic effects of endocannabinoids. Finally, we review recent observations that indicate that peripherally restricted CB1 receptor antagonists retain efficacy in reducing weight and improving metabolic abnormalities in mouse models of obesity without causing behavioural effects predictive of neuropsychiatric side effects in humans. LINKED ARTICLES This article is part of a themed issue on Cannabinoids in Biology and Medicine. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2011.163.issue-7 JF - British Journal of Pharmacology AU - Kunos, George AU - Tam, Joseph Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 1423 EP - 1431 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 163 IS - 7 SN - 1476-5381, 1476-5381 KW - Physical Education Index KW - Obesity KW - Nervous system KW - Diet (weight control) KW - Liver KW - Medicine KW - Observation KW - Hormones KW - Self efficacy KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1427004711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Pharmacology&rft.atitle=The+case+for+peripheral+CB1+receptor+blockade+in+the+treatment+of+visceral+obesity+and+its+cardiometabolic+complications&rft.au=Kunos%2C+George%3BTam%2C+Joseph&rft.aulast=Kunos&rft.aufirst=George&rft.date=2011-08-01&rft.volume=163&rft.issue=7&rft.spage=1423&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Pharmacology&rft.issn=14765381&rft_id=info:doi/10.1111%2Fj.1476-5381.2011.01352.x L2 - http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01352.x/abstract LA - English DB - Physical Education Index N1 - Date revised - 2013-08-01 N1 - Last updated - 2013-08-23 N1 - SubjectsTermNotLitGenreText - Obesity; Nervous system; Liver; Diet (weight control); Observation; Medicine; Hormones; Self efficacy DO - http://dx.doi.org/10.1111/j.1476-5381.2011.01352.x ER - TY - JOUR T1 - Persistent Organochlorine Exposure and Pregnancy Loss: A Prospective Cohort Study AN - 1356925318; 15754163 AB - Polychlorinated biphenyls (PCBs) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) are suspected reproductive toxicants. We assessed serum concentration of 76 PCB congeners, DDE, and risk of human chorionic gonadotropin confirmed pregnancy loss among 79 women followed for up to 12 menstrual cycles or until pregnancy. 55 women had live births, 14 experienced pregnancy losses, and 10 did not achieve pregnancy. PCBs and DDE were quantified using gas chromatography with electron capture. PCBs were grouped a priori by biologic activity. Cox proportional hazard regression adjusting for age (categorized 24 - 29, 30 - 34) and average standardized alcohol and cigarette intake (continuous) was used to estimate hazard ratios (HR) of pregnancy loss. Estrogenic PCBs (HR = 1.66, 95% CI: 0.68, 4.02), anti-estrogenic PCBs (HR = 0.10, 95% CI: <0.01, 67.07) and DDE (HR = 1.43, 95% CI: 0.45, 4.52) were not statistically significantly associated with pregnancy loss. Our results provide some signal that estrogenic and antiestrogenic PCBs may be differentially associated with pregnancy loss. Further research is needed to elucidate these associations. JF - Journal of Environmental Protection AU - Pollack, Anna Z AU - Louis, Germaine M Buck AU - Lynch, Courtney D AU - Kostyniak, Paul J AD - Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, USA; 2 Division of Epidemiology & Department of Obstetrics and Gynecology, Ohio State University, Columbus, USA; 3Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University of New York, Buffalo, USA. Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 683 PB - Scientific Research Publishing VL - 2 IS - 6 SN - 2152-2197, 2152-2197 KW - Toxicology Abstracts KW - Age KW - Organochlorine compounds KW - chorionic gonadotropin KW - Toxicants KW - Cigarettes KW - Abortion KW - DDE KW - Environmental protection KW - Pregnancy KW - polychlorinated biphenyls KW - Gas chromatography KW - Congeners KW - PCB KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1356925318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Protection&rft.atitle=Persistent+Organochlorine+Exposure+and+Pregnancy+Loss%3A+A+Prospective+Cohort+Study&rft.au=Pollack%2C+Anna+Z%3BLouis%2C+Germaine+M+Buck%3BLynch%2C+Courtney+D%3BKostyniak%2C+Paul+J&rft.aulast=Pollack&rft.aufirst=Anna&rft.date=2011-08-01&rft.volume=2&rft.issue=6&rft.spage=683&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Protection&rft.issn=21522197&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Number of references - 49 N1 - Last updated - 2013-06-14 N1 - SubjectsTermNotLitGenreText - Age; Organochlorine compounds; Cigarettes; Toxicants; chorionic gonadotropin; Abortion; DDE; Environmental protection; Pregnancy; polychlorinated biphenyls; Gas chromatography; Congeners; PCB; Ethanol ER - TY - JOUR T1 - Inner-City Environments and Mitigation of Cockroach Allergen AN - 1221435153; 201229434 AB - One of several commentaries in a special journal issue devoted to the issue of reducing asthma morbidity through home-based environmental interventions. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Sever, Michelle L AU - Salo, Paivi M AU - Haynes, Amber K AU - Zeldin, Darryl C Y1 - 2011/08// PY - 2011 DA - August 2011 SP - S55 EP - S56 PB - Elsevier Science, New York NY VL - 41 IS - 2 SN - 0749-3797, 0749-3797 KW - Inner cities KW - Mitigation KW - Home based KW - Interventions KW - Asthma KW - Morbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1221435153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Inner-City+Environments+and+Mitigation+of+Cockroach+Allergen&rft.au=Sever%2C+Michelle+L%3BSalo%2C+Paivi+M%3BHaynes%2C+Amber+K%3BZeldin%2C+Darryl+C&rft.aulast=Sever&rft.aufirst=Michelle&rft.date=2011-08-01&rft.volume=41&rft.issue=2&rft.spage=S55&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2011.05.007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-12-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Home based; Interventions; Mitigation; Asthma; Inner cities; Morbidity DO - http://dx.doi.org/10.1016/j.amepre.2011.05.007 ER - TY - JOUR T1 - Users' Attitude and Strategies in Information Management with Multiple Computers AN - 1081858475; 201210014 AB - This article reports the result of a survey study on how users utilize multiple computers in personal information management tasks. Two hundred ninety-five experienced computer users answered questions regarding the selective use of computers in three usage scenarios in managing multiple types of information: files, bookmarks, and e-mails. Results showed that users pursue simple computing environment by simplifying multiple computer configurations, avoiding distribution of information among multiple computers, and avoiding conceptual distinction of multiple computers. Selective use of a computer was based on the characteristics of the computers and the tasks to be performed. Information retrieval was still primarily done manually due to problems of memory decay and information overload. It was concluded that user attitudes and strategies in using multiple computers were characterized by reactive coping and avoidance of challenges. This article provides evidence of users' problems with multiple computers and highlights the need to support the seamless usage of multiple computers. Adapted from the source document. JF - International Journal of Human-Computer Interaction AU - Song, Guangfeng AU - Ling, Chen AD - National Institutes of Health/National Center for Biotechnology Information, Bethesda, Maryland Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 762 EP - 792 PB - Taylor & Francis, Philadelphia PA VL - 27 IS - 8 SN - 1044-7318, 1044-7318 KW - Attitudes KW - Computers KW - Information management KW - User behaviour KW - article KW - 10.1: INFORMATION WORK UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081858475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Human-Computer+Interaction&rft.atitle=Users%27+Attitude+and+Strategies+in+Information+Management+with+Multiple+Computers&rft.au=Song%2C+Guangfeng%3BLing%2C+Chen&rft.aulast=Song&rft.aufirst=Guangfeng&rft.date=2011-08-01&rft.volume=27&rft.issue=8&rft.spage=762&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Human-Computer+Interaction&rft.issn=10447318&rft_id=info:doi/10.1080%2F10447318.2011.555307 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - IJHIEC N1 - SubjectsTermNotLitGenreText - User behaviour; Computers; Information management; Attitudes DO - http://dx.doi.org/10.1080/10447318.2011.555307 ER - TY - JOUR T1 - Antibiotic resistance is associated with longer bacteremic episodes and worse outcome in febrile neutropenic children with cancer AN - 1020853876; 16712737 AB - Purpose With the increasing emergence of multiresistant pathogens, better understanding of these infections is necessary. The aim of the present study was to evaluate the risk factors associated with isolating a multiresistant organism (MRO) from a positive blood culture in pediatric cancer patients with febrile neutropenia (F&N), and to study its impact on clinical course and outcome of febrile episodes. Patients and Methods The association between MRO with underlying malignancy, age, disease status, hospitalization during episode, absolute neutrophil count, absolute monocyte count, clinical foci of infection, and pathogens isolated was assessed in bacteremic pediatric cancer patients. The MRO phenotype was defined as diminished susceptibility to >=3 of the broad spectrum antibody classes. Results Among 239 episodes of blood stream infections (BSI), Gram-positive, and Gram-negative organisms were detected in 180 (75%), and 59(25%) episodes, respectively; with 38% of isolates showing multiresistance (n=92). Significant risk factors (P<0.05) for MRO were hospitalization, Gram-negative organisms, presence of clinical focus of infection, reduced ANC, prolonged duration of neutropenia, and previous intake of antibiotics. Of the episodes with prolonged duration of fever extending for more than 7 days 62% (64|93) were associated with a multiresistant phenotype, while it accompanied 72% (18|25) of the cases with an unfavorable outcome; P-value <0.001. Conclusion Isolation of MRO is more likely to be associated with a prolonged course and an unfavorable outcome. Continuous multidisciplinary surveillance of BSI is warranted to develop strategies for antimicrobial resistance control. Pediatr Blood Cancer 2011; 57: 283-288. ? 2010 Wiley-Liss, Inc. JF - Pediatric Blood & Cancer AU - El-Mahallawy, Hadir A AU - El-Wakil, Mohamed AU - Moneer, Manar M AU - Shalaby, Lobna AD - Clinical Pathology Department, National Cancer Institute, Cairo University, Egypt, hadir38@hotmail.com Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 283 EP - 288 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 57 IS - 2 SN - 1545-5017, 1545-5017 KW - Microbiology Abstracts B: Bacteriology KW - Age KW - Antibiotic resistance KW - Antibiotics KW - Antibodies KW - Blood culture KW - Cancer KW - Children KW - Drug resistance KW - Fever KW - Infection KW - Leukocytes (neutrophilic) KW - Malignancy KW - Monocytes KW - Neutropenia KW - Pathogens KW - Pediatrics KW - Risk factors KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020853876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+Blood+%26+Cancer&rft.atitle=Antibiotic+resistance+is+associated+with+longer+bacteremic+episodes+and+worse+outcome+in+febrile+neutropenic+children+with+cancer&rft.au=El-Mahallawy%2C+Hadir+A%3BEl-Wakil%2C+Mohamed%3BMoneer%2C+Manar+M%3BShalaby%2C+Lobna&rft.aulast=El-Mahallawy&rft.aufirst=Hadir&rft.date=2011-08-01&rft.volume=57&rft.issue=2&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Pediatric+Blood+%26+Cancer&rft.issn=15455017&rft_id=info:doi/10.1002%2Fpbc.22926 L2 - http://onlinelibrary.wiley.com/doi/10.1002/pbc.22926/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Blood culture; Age; Pediatrics; Drug resistance; Leukocytes (neutrophilic); Antibiotics; Pathogens; Children; Infection; Cancer; Fever; Neutropenia; Antibodies; Malignancy; Risk factors; Monocytes; Antibiotic resistance DO - http://dx.doi.org/10.1002/pbc.22926 ER - TY - JOUR T1 - Exotic fruits as therapeutic complements for diabetes, obesity and metabolic syndrome AN - 1020840558; 15590413 AB - The prevalence and severity of obesity, type 2-diabetes, and the resultant metabolic syndrome are rapidly increasing. As successful preventive and therapeutic strategies for these life-threatening health ailments often come with adverse side effects, nutritional elements are widely used in many countries as preventive therapies to prevent or manage metabolic syndrome. Fruits are important dietary components, and contain various bioactive constituents. Many of these constituents have been proven to be useful to manage and treat various chronic diseases such as diabetes, obesity, cancer and cardiovascular diseases. Although exotic fruits are understudied throughout the world due to their limited regional presence, many studies reveal their potent ability to ameliorate metabolic derangements and the resultant conditions i.e. diabetes and obesity. The aim of this article is to review the role of exotic fruits and their constituents in the regulation of metabolic functions, which can beneficially alter diabetes and obesity pathophysiology. JF - Food Research International AU - Devalaraja, Samir AU - Jain, Shalini AU - Yadav, Hariom Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 1856 EP - 1865 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 44 IS - 7 SN - 0963-9969, 0963-9969 KW - Physical Education Index KW - Cancer KW - Obesity KW - PE:030 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020840558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Research+International&rft.atitle=Exotic+fruits+as+therapeutic+complements+for+diabetes%2C+obesity+and+metabolic+syndrome&rft.au=Devalaraja%2C+Samir%3BJain%2C+Shalini%3BYadav%2C+Hariom&rft.aulast=Devalaraja&rft.aufirst=Samir&rft.date=2011-08-01&rft.volume=44&rft.issue=7&rft.spage=1856&rft.isbn=&rft.btitle=&rft.title=Food+Research+International&rft.issn=09639969&rft_id=info:doi/10.1016%2Fj.foodres.2011.04.008 LA - English DB - Physical Education Index N1 - Date revised - 2012-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Obesity DO - http://dx.doi.org/10.1016/j.foodres.2011.04.008 ER - TY - JOUR T1 - The Urgency Of Providing Comprehensive And Integrated Treatment For Substance Abusers With HIV AN - 1018364469; 201202640 AB - Substance abuse is linked to many new cases of HIV infection. Barriers such as the myth that drug users cannot adhere to HIV/AIDS treatment block progress in curbing the spread of HIV in that population. In this article we explain the need to aggressively seek out high-risk, hard-to-reach substance abusers and to offer them HIV testing, access to treatment, and the necessary support to remain in treatment-both for HIV and for substance abuse. We summarize evidence showing that injection drug users can successfully undergo HIV treatment; that many substance abusers adhere to antiretroviral therapy as well as do people who don't inject drugs; and that injection drug users who undergo substance abuse treatment are more likely to obtain and stay in treatment for their HIV infection. This evidence makes a strong case for integrating substance abuse treatment with HIV treatment programs and providing substance abusers with universal access to HIV treatment. But an integrated strategy will require changes in the health care system to overcome lingering obstacles that inhibit the merging of substance abuse treatment with HIV programs. Adapted from the source document. JF - Health Affairs AU - Volkow, Nora D AU - Montaner, Julio AD - National Institute on Drug Abuse, in Bethesda, Maryland nvolkow@nida.nih.gov Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 1411 EP - 1419 PB - Project HOPE, Bethesda MD VL - 30 IS - 8 SN - 0278-2715, 0278-2715 KW - Drug Injection KW - Substance Abuse KW - Treatment Programs KW - Acquired Immune Deficiency Syndrome KW - Constraints KW - Medications KW - Treatment KW - Drug Abuse KW - Health Care Services KW - article KW - 6129: addiction KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018364469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=The+Urgency+Of+Providing+Comprehensive+And+Integrated+Treatment+For+Substance+Abusers+With+HIV&rft.au=Volkow%2C+Nora+D%3BMontaner%2C+Julio&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2011-08-01&rft.volume=30&rft.issue=8&rft.spage=1411&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2011.0663 LA - English DB - Social Services Abstracts N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Substance Abuse; Treatment; Drug Injection; Treatment Programs; Health Care Services; Medications; Drug Abuse; Constraints DO - http://dx.doi.org/10.1377/hlthaff.2011.0663 ER - TY - JOUR T1 - Hofmeister series salts enhance purification of plasmid DNA by non-ionic detergents AN - 1017966979; 16691892 AB - Ion-exchange chromatography is the standard technique used for plasmid DNA purification, an essential molecular biology procedure. Non-ionic detergents (NIDs) have been used for plasmid DNA purification, but it is unclear whether Hofmeister series salts (HSS) change the solubility and phase separation properties of specific NIDs, enhancing plasmid DNA purification. After scaling-up NID-mediated plasmid DNA isolation, we established that NIDs in HSS solutions minimize plasmid DNA contamination with protein. In addition, large-scale NID/HSS solutions eliminated lipopolysaccharides (LPS) contamination of plasmid DNA more effectively than Qiagen ion-exchange columns. Large-scale NID isolation/NID purification generated increased yields of high-quality DNA compared to alkali isolation/column purification. This work characterizes how HSS enhance NID-mediated plasmid DNA purification, and demonstrates that NID phase transition is not necessary for LPS removal from plasmid DNA. Specific NIDs such as IGEPAL CA-520 can be utilized for rapid, inexpensive, and efficient laboratory-based large-scale plasmid DNA purification, outperforming Qiagen-based column procedures. Biotechnol. Bioeng. 2011; 108:1872-1882. ? 2011 Wiley Periodicals, Inc. JF - Biotechnology and Bioengineering AU - Lezin, George AU - Kuehn, Michael R AU - Brunelli, Luca AD - Laboratory of Protein Dynamics and Signaling, National Cancer Institute, National Institutes of Health, NCI-Frederick, Frederick, Maryland 21702; telephone: 301-846-7451; fax: 301-846-1666, mkuehn@mail.nih.gov Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 1872 EP - 1882 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 108 IS - 8 SN - 1097-0290, 1097-0290 KW - Biochemistry Abstracts 2: Nucleic Acids; Water Resources Abstracts; Aqualine Abstracts; Biotechnology and Bioengineering Abstracts KW - Contamination KW - Detergents KW - Isolation KW - Lipopolysaccharides KW - Alkalis KW - Solubility KW - Chromatography KW - Ion-exchange chromatography KW - Plasmids KW - Salts KW - Analytical Methods KW - DNA KW - Standards KW - Phase transition KW - Biotechnology KW - AQ 00001:Water Resources and Supplies KW - W 30905:Medical Applications KW - SW 3050:Ultimate disposal of wastes KW - N 14845:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017966979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+and+Bioengineering&rft.atitle=Hofmeister+series+salts+enhance+purification+of+plasmid+DNA+by+non-ionic+detergents&rft.au=Lezin%2C+George%3BKuehn%2C+Michael+R%3BBrunelli%2C+Luca&rft.aulast=Lezin&rft.aufirst=George&rft.date=2011-08-01&rft.volume=108&rft.issue=8&rft.spage=1872&rft.isbn=&rft.btitle=&rft.title=Biotechnology+and+Bioengineering&rft.issn=10970290&rft_id=info:doi/10.1002%2Fbit.23116 L2 - http://onlinelibrary.wiley.com/doi/10.1002/bit.23116/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Salts; Solubility; Contamination; Detergents; Ion-exchange chromatography; DNA; Lipopolysaccharides; Phase transition; Alkalis; Plasmids; Chromatography; Analytical Methods; Standards; Isolation; Biotechnology DO - http://dx.doi.org/10.1002/bit.23116 ER - TY - JOUR T1 - Hyperthermia-triggered intracellular delivery of anticancer agent to HER2 super(+ cells by HER2-specific affibody (ZHER2-GS-Cys)-conjugated thermosensitive liposomes (HER2) super(+) affisomes) AN - 883028366; 15320917 AB - We previously reported the formulation and physical properties of HER2 (human epidermal growth factor receptor 2)-specific affibody (ZHER2:342-Cys) conjugated thermosensitive liposomes (HER2 super(+affisomes). Here we examined localized delivery potential of these affisomes by monitoring cellular interactions, intracellular uptake, and hyperthermia-induced effects on drug delivery. We modified ZHER2:342-Cys by introducing a glycine-serine spacer before the C-terminus cysteine (called ZHER2-GS-Cys) to achieve accessibility to cell surface expressed HER2. This modification did not affect HER2-specific binding and ZHER2-GS-Cys retained its ability to conjugate to the liposomes containing dipalmitoyl phosphatidyl choline: DSPE-PEG2000-Malemide, 96:04 mole ratios (HER2) super(+)affisomes). HER2 super(+affisomes were either (i) fluorescently labeled with rhodamine-PE and calcein or (ii) loaded with an anticancer drug doxorubicin (DOX). Fluorescently labeled HER2) super(+) affisomes showed at least 10-fold increase in binding to HER2 super(+ cells (SK-BR-3) when compared to HER2) super(-) cells (MDA-MB-468) at 37 degree C. A competition experiment using free ZHER2-GS-Cys blocked HER2 super(+ affisome-SK-BR-3 cell associations. Imaging with confocal microscopy showed that HER2) super(+) affisomes accumulated in the cytosol of SK-BR-3 cells at 37 degree C. Hyperthermia-induced intracellular release experiments showed that the treatment of HER2 super(+ affisome/SK-BR-3 cell complexes with a 45 degree C (+/- 1 degree C) pre-equilibrated buffer resulted in cytosolic delivery of calcein. Substantial calcein release was observed within 20 min at 45 degree C, with no effect on cell viability under these conditions. Similarly, DOX-loaded HER2) super(+)affisomes showed at least 2- to 3-fold higher accumulation of DOX in SK-BR-3 cells as compared to control liposomes. DOX-mediated cytotoxicity was more pronounced in SK-BR-3 cells especially at lower doses of HER2 super(+affisomes. Brief exposure of liposome-cell complexes at 45 degree C prior to the onset of incubations for cell killing assays resulted in enhanced cytotoxicity for affisomes and control liposomes. However, Doxil (a commercially available liposome formulation) showed significantly lower toxicity under identical conditions. Therefore, our data demonstrate that HER2) super(+)affisomes encompass both targeting and triggering potential and hence may prove to be viable nanodrug delivery carriers for breast cancer treatment. JF - Journal of Controlled Release AU - Smith, Brandon AU - Lyakhov, Ilya AU - Loomis, Kristin AU - Needle, Danielle AU - Baxa, Ulrich AU - Yavlovich, Amichai AU - Capala, Jacek AU - Blumenthal, Robert AU - Puri, Anu AD - CCR Nanobiology Program, NCI, Frederick, MD, USA, puria@mail.nih.gov Y1 - 2011/07/30/ PY - 2011 DA - 2011 Jul 30 SP - 187 EP - 194 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 153 IS - 2 SN - 0168-3659, 0168-3659 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Cell surface KW - Choline KW - ErbB-2 protein KW - Data processing KW - Calcein KW - C-Terminus KW - Spacer KW - Epidermal growth factor receptors KW - Toxicity KW - Controlled release KW - Antitumor agents KW - Liposomes KW - Doxorubicin KW - Cytotoxicity KW - Cysteine KW - Confocal microscopy KW - Cytosol KW - Breast cancer KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883028366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Controlled+Release&rft.atitle=Hyperthermia-triggered+intracellular+delivery+of+anticancer+agent+to+HER2+super%28%2B+cells+by+HER2-specific+affibody+%28ZHER2-GS-Cys%29-conjugated+thermosensitive+liposomes+%28HER2%29+super%28%2B%29+affisomes%29&rft.au=Smith%2C+Brandon%3BLyakhov%2C+Ilya%3BLoomis%2C+Kristin%3BNeedle%2C+Danielle%3BBaxa%2C+Ulrich%3BYavlovich%2C+Amichai%3BCapala%2C+Jacek%3BBlumenthal%2C+Robert%3BPuri%2C+Anu&rft.aulast=Smith&rft.aufirst=Brandon&rft.date=2011-07-30&rft.volume=153&rft.issue=2&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Journal+of+Controlled+Release&rft.issn=01683659&rft_id=info:doi/10.1016%2Fj.jconrel.2011.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Cell surface; Drug delivery; Choline; Data processing; ErbB-2 protein; Calcein; C-Terminus; Epidermal growth factor receptors; Spacer; Toxicity; Liposomes; Antitumor agents; Controlled release; Doxorubicin; Cytotoxicity; Cysteine; Confocal microscopy; Cytosol; Breast cancer DO - http://dx.doi.org/10.1016/j.jconrel.2011.04.005 ER - TY - JOUR T1 - Practical modifications to the time-to-event continual reassessment method for phase I cancer trials with fast patient accrual and late-onset toxicities. AN - 874894980; 21590790 AB - The goal of phase I cancer trials is to determine the highest dose of a treatment regimen with an acceptable toxicity rate. Traditional designs for phase I trials, such as the Continual Reassessment Method (CRM) and the 3 + 3 design, require each patient or a cohort of patients to be fully evaluated for the dose-limiting toxicity (DLT) before new patients can be enrolled. As such, the trial duration may be prohibitively long. The Time-to-Event Continual Reassessment Method (TITE-CRM, Cheung and Chappell, 2000) circumvents this limitation by allowing staggered patient accrual without the need for complete DLT follow-up of previously treated patients. However, in the setting of fast patient accrual and late-onset toxicities, the TITE-CRM results in overly aggressive dose escalation and exposes a considerable number of patients to toxic doses. We examine a modification to the TITE-CRM proposed by the original TITE-CRM creator and propose an alternative approach useful in this setting by incorporating an accrual suspension rule. A simulation study designed based on a neuro-oncology trial indicates that the modified methods provide a much improved degree of safety than the TITE-CRM while maintaining desirable design accuracy. The practical aspects of the proposed designs are discussed. The modifications presented are useful when planning phase I trials involving chemoradiation therapy. Copyright © 2011 John Wiley & Sons, Ltd. JF - Statistics in medicine AU - Polley, Mei-Yin C AD - Biometric Research Branch, National Caner Institute, Executive Plaza North, Room 8124, 6130 Executive Boulevard, Rockville, MD 20852, USA. polleymc@mail.nih.gov Y1 - 2011/07/30/ PY - 2011 DA - 2011 Jul 30 SP - 2130 EP - 2143 VL - 30 IS - 17 KW - Index Medicus KW - Computer Simulation KW - Dose-Response Relationship, Drug KW - Humans KW - Research Design KW - Clinical Trials, Phase I as Topic -- methods KW - Models, Statistical KW - Maximum Tolerated Dose UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874894980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistics+in+medicine&rft.atitle=Practical+modifications+to+the+time-to-event+continual+reassessment+method+for+phase+I+cancer+trials+with+fast+patient+accrual+and+late-onset+toxicities.&rft.au=Polley%2C+Mei-Yin+C&rft.aulast=Polley&rft.aufirst=Mei-Yin&rft.date=2011-07-30&rft.volume=30&rft.issue=17&rft.spage=2130&rft.isbn=&rft.btitle=&rft.title=Statistics+in+medicine&rft.issn=1097-0258&rft_id=info:doi/10.1002%2Fsim.4255 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-01 N1 - Date created - 2011-07-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 2000 Feb;18(3):684-92 [10653884] Stat Med. 2009 Oct 30;28(24):3012-28 [19672839] Biometrics. 2001 Dec;57(4):1018-29 [11764240] Control Clin Trials. 2002 Jun;23(3):240-56 [12057877] Stat Med. 2002 Jul 15;21(13):1805-23 [12111891] Stat Med. 2002 Sep 30;21(18):2757-70 [12228889] Biometrics. 2002 Sep;58(3):671-4 [12230003] Control Clin Trials. 2003 Dec;24(6):669-81 [14662273] J Clin Oncol. 2004 Jan 15;22(2):238-43 [14665608] Biometrics. 1989 Sep;45(3):925-37 [2790129] Biometrics. 1990 Mar;46(1):33-48 [2350571] Stat Med. 1991 Nov;10(11):1647-64 [1792460] Stat Med. 1993 Jun 30;12(12):1093-108 [8210815] Stat Med. 1994 Sep 30;13(18):1799-806 [7997713] Stat Med. 1995 Jun 15;14(11):1149-61 [7667557] Biometrics. 1996 Jun;52(2):673-84 [8672707] Cancer Chemother Pharmacol. 1998;41(6):429-36 [9554585] Stat Med. 1999 Jun 15;18(11):1307-21 [10399198] Br J Cancer. 2006 Mar 13;94(5):609-13 [16434987] Stat Med. 2006 Jun 30;25(12):2071-83 [16217853] J Clin Oncol. 2006 Sep 20;24(27):4426-33 [16983110] Biostatistics. 2008 Jul;9(3):442-57 [18084008] Int J Stroke. 2008 Aug;3(3):210-8 [18705902] J Natl Cancer Inst. 2009 May 20;101(10):708-20 [19436029] Clin Trials. 2009 Jun;6(3):227-38 [19528132] Biometrics. 2000 Dec;56(4):1177-82 [11129476] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/sim.4255 ER - TY - JOUR T1 - Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin. AN - 887939848; 21657271 AB - A major challenge in the treatment of cancer is multidrug resistance (MDR) that develops during chemotherapy. Here we demonstrate that tiopronin (1), a thiol-substituted N-propanoylglycine derivative, was selectively toxic to a series of cell lines expressing the drug efflux pump P-glycoprotein (P-gp, ABCB1) and MRP1 (ABCC1). Treatment of MDR cells with 1 led to instability of the ABCB1 mRNA and consequently a reduction in P-gp protein, despite functional assays demonstrating that tiopronin does not interact with P-gp. Long-term exposure of P-gp-expressing cells to 1 sensitized them to doxorubicin and paclitaxel, both P-gp substrates. Treatment of MRP1-overexpressing cells with tiopronin led to a significant reduction in MRP1 protein. Synthesis and screening of analogues of tiopronin demonstrated that the thiol functional group was essential for collateral sensitivity while substitution of the amino acid backbone altered but did not destroy specificity, pointing to future development of targeted analogues. JF - Journal of medicinal chemistry AU - Goldsborough, Andrew S AU - Handley, Misty D AU - Dulcey, Andrés E AU - Pluchino, Kristen M AU - Kannan, Pavitra AU - Brimacombe, Kyle R AU - Hall, Matthew D AU - Griffiths, Gary AU - Gottesman, Michael M AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2011/07/28/ PY - 2011 DA - 2011 Jul 28 SP - 4987 EP - 4997 VL - 54 IS - 14 KW - ABCB1 protein, human KW - 0 KW - Antineoplastic Agents KW - Multidrug Resistance-Associated Proteins KW - P-Glycoprotein KW - P-Glycoproteins KW - RNA, Messenger KW - Doxorubicin KW - 80168379AG KW - Tiopronin KW - C5W04GO61S KW - Paclitaxel KW - P88XT4IS4D KW - multidrug resistance-associated protein 1 KW - Y49M64GZ4Q KW - Index Medicus KW - Drug Screening Assays, Antitumor KW - HEK293 Cells KW - Humans KW - RNA Stability KW - Orphan Drug Production KW - Cell Line, Tumor KW - Paclitaxel -- pharmacology KW - Structure-Activity Relationship KW - RNA, Messenger -- metabolism KW - Doxorubicin -- pharmacology KW - P-Glycoprotein -- genetics KW - P-Glycoprotein -- metabolism KW - Multidrug Resistance-Associated Proteins -- metabolism KW - Tiopronin -- chemical synthesis KW - Drug Resistance, Multiple -- drug effects KW - Antineoplastic Agents -- chemical synthesis KW - Antineoplastic Agents -- chemistry KW - Tiopronin -- pharmacology KW - Antineoplastic Agents -- pharmacology KW - Tiopronin -- chemistry KW - Drug Resistance, Neoplasm -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/887939848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Collateral+sensitivity+of+multidrug-resistant+cells+to+the+orphan+drug+tiopronin.&rft.au=Goldsborough%2C+Andrew+S%3BHandley%2C+Misty+D%3BDulcey%2C+Andr%C3%A9s+E%3BPluchino%2C+Kristen+M%3BKannan%2C+Pavitra%3BBrimacombe%2C+Kyle+R%3BHall%2C+Matthew+D%3BGriffiths%2C+Gary%3BGottesman%2C+Michael+M&rft.aulast=Goldsborough&rft.aufirst=Andrew&rft.date=2011-07-28&rft.volume=54&rft.issue=14&rft.spage=4987&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm2001663 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-10 N1 - Date created - 2011-07-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Annu Rev Med. 2002;53:615-27 [11818492] J Pharmacol Toxicol Methods. 2011 May-Jun;63(3):217-22 [21112407] Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5579-84 [11943872] Cancer Res. 2003 Jun 15;63(12):3084-91 [12810633] Eur Urol. 1975;1(5):227-8 [1233187] J Radiat Res. 1977 May;18(2):160-3 [886525] Teratology. 1979 Oct;20(2):297-301 [524302] Cell. 1980 May;20(1):29-36 [7388944] Proc Natl Acad Sci U S A. 1981 Jul;78(7):4388-91 [6117076] Arthritis Rheum. 1982 Jun;25(6):698-703 [7046758] Somat Cell Mol Genet. 1985 Mar;11(2):117-26 [3856953] J Biol Chem. 1986 Jun 15;261(17):7762-70 [3711108] Cell Biol Int Rep. 1986 May;10(5):389-99 [3719706] Jpn J Cancer Res. 1989 Apr;80(4):394-9 [2526108] Free Radic Biol Med. 1989;7(6):659-73 [2695409] Br J Cancer. 1992 Nov;66(5):781-6 [1358166] Cancer Res. 1994 Jan 1;54(1):152-8 [7903202] Int J Cancer. 1994 Mar 1;56(5):749-54 [7906257] Cancer Res. 1995 Mar 1;55(5):1086-91 [7866993] Br J Cancer. 1995 Apr;71(4):676-83 [7710928] J Urol. 1996 Nov;156(5):1576-8 [8863541] Mutat Res. 1998 Jan 30;412(2):207-12 [9539975] Int J Audiol. 2004 Sep;43(8):465-70 [15643740] Cancer Res. 2006 May 1;66(9):4808-15 [16651436] Trends Pharmacol Sci. 2006 Aug;27(8):438-46 [16820223] J Biol Chem. 2006 Dec 1;281(48):36501-9 [16956878] Oncol Rep. 2007 Sep;18(3):721-7 [17671726] Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3271-8 [18089721] J Med Chem. 2009 May 28;52(10):3191-204 [19397322] Assay Drug Dev Technol. 2009 Jun;7(3):233-49 [19548831] Trends Pharmacol Sci. 2009 Oct;30(10):546-56 [19762091] Neurosurgery. 2010 Jul;67(1):182-5; discussion 186 [20559104] Nat Rev Cancer. 2002 Jan;2(1):48-58 [11902585] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm2001663 ER - TY - CPAPER T1 - Seasonal variation in metabolism, flight activity, and ecology of Anopheles gambiae in Mali T2 - Joint Meeting of the International Ethological Conference (IEC) and the Animal Behavior Society (ABS) 48th Annual Meeting (Behaviour 2011) AN - 1312950140; 6035501 JF - Joint Meeting of the International Ethological Conference (IEC) and the Animal Behavior Society (ABS) 48th Annual Meeting (Behaviour 2011) AU - Huestis, Diana AU - Yaro, A AU - Traore, A AU - Dieter, K AU - Nwagbara, J AU - A, Bowie AU - Dao, A AU - Lehmann, T Y1 - 2011/07/25/ PY - 2011 DA - 2011 Jul 25 KW - Mali KW - Seasonal variations KW - Ecology KW - Metabolism KW - Flight activity KW - Aquatic insects KW - Anopheles gambiae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312950140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+Meeting+of+the+International+Ethological+Conference+%28IEC%29+and+the+Animal+Behavior+Society+%28ABS%29+48th+Annual+Meeting+%28Behaviour+2011%29&rft.atitle=Seasonal+variation+in+metabolism%2C+flight+activity%2C+and+ecology+of+Anopheles+gambiae+in+Mali&rft.au=Huestis%2C+Diana%3BYaro%2C+A%3BTraore%2C+A%3BDieter%2C+K%3BNwagbara%2C+J%3BA%2C+Bowie%3BDao%2C+A%3BLehmann%2C+T&rft.aulast=Huestis&rft.aufirst=Diana&rft.date=2011-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+Meeting+of+the+International+Ethological+Conference+%28IEC%29+and+the+Animal+Behavior+Society+%28ABS%29+48th+Annual+Meeting+%28Behaviour+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.indiana.edu/~behav11/PostersSchedule.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - De-AMPylation of the Small GTPase Rab1 by the Pathogen Legionella pneumophila AN - 899173140; 15376749 AB - The bacterial pathogen Legionella pneumophila exploits host cell vesicle transport by transiently manipulating the activity of the small guanosine triphosphatase (GTPase) Rab1. The effector protein SidM recruits Rab1 to the Legionella-containing vacuole (LCV), where it activates Rab1 and then AMPylates it by covalently adding adenosine monophosphate (AMP). L. pneumophila GTPase-activating protein LepB inactivates Rab1 before its removal from LCVs. Because LepB cannot bind AMPylated Rab1, the molecular events leading to Rab1 inactivation are unknown. We found that the effector protein SidD from L. pneumophila catalyzed AMP release from Rab1, generating de-AMPylated Rab1 accessible for inactivation by LepB. L. pneumophila mutants lacking SidD were defective for Rab1 removal from LCVs, identifying SidD as the missing link connecting the processes of early Rab1 accumulation and subsequent Rab1 removal during infection. JF - Science (Washington) AU - Neunuebel, MRamona AU - Chen, Yang AU - Gaspar, Andrew H AU - Backlund, Peter S AU - Yergey, Alfred AU - Machner, Matthias P AD - Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA Y1 - 2011/07/22/ PY - 2011 DA - 2011 Jul 22 SP - 453 EP - 456 PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 United States VL - 333 IS - 6041 SN - 0036-8075, 0036-8075 KW - Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources KW - GTPase-activating protein KW - Legionella pneumophila KW - Recruitment KW - AMP KW - Pathogens KW - Infection KW - Triphosphatase KW - Vacuoles KW - Vesicles KW - Guanosine KW - Guanosinetriphosphatase KW - J 02310:Genetics & Taxonomy KW - Q1 08484:Species interactions: parasites and diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899173140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=De-AMPylation+of+the+Small+GTPase+Rab1+by+the+Pathogen+Legionella+pneumophila&rft.au=Neunuebel%2C+MRamona%3BChen%2C+Yang%3BGaspar%2C+Andrew+H%3BBacklund%2C+Peter+S%3BYergey%2C+Alfred%3BMachner%2C+Matthias+P&rft.aulast=Neunuebel&rft.aufirst=MRamona&rft.date=2011-07-22&rft.volume=333&rft.issue=6041&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Recruitment; AMP; Pathogens; GTPase-activating protein; Triphosphatase; Vacuoles; Vesicles; Guanosine; Infection; Guanosinetriphosphatase; Legionella pneumophila ER - TY - JOUR T1 - Hepatitis C Virus Infection and Coinfection With Human Immunodeficiency Virus: Challenges and Advancements in Management AN - 899161802; 15376329 AB - Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) both emerged in the second half of the 20th century, and chronic infection with these agents is among the greatest challenges facing health care in the United States and worldwide. Despite tremendous advances in treatment and management of HIV and HCV, individuals with HIV/HCV coinfection experience a more complicated disease course and treatment. Recognition of the important role that host factors, such as IL28B genotype, have in response to HCV therapy and the emergence of new effective therapies for HCV are actively reshaping the standard of care. These advances may translate into more effective treatment and management of patients with chronic HCV and HIV coinfection in the years ahead. JF - JAMA: Journal of the American Medical Association AU - Hadigan, Colleen AU - Kottilil, Shyamasundaran AD - Author Affiliations: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Y1 - 2011/07/20/ PY - 2011 DA - 2011 Jul 20 SP - 294 EP - 301 PB - American Medical Association, 515 N. State St. Chicago IL 60610 United States VL - 306 IS - 3 SN - 0098-7484, 0098-7484 KW - Immunology Abstracts; Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Hepatitis KW - USA KW - Hepatitis C virus KW - Health care KW - Human immunodeficiency virus KW - Chronic infection KW - infection KW - Genotypes KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899161802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Hepatitis+C+Virus+Infection+and+Coinfection+With+Human+Immunodeficiency+Virus%3A+Challenges+and+Advancements+in+Management&rft.au=Hadigan%2C+Colleen%3BKottilil%2C+Shyamasundaran&rft.aulast=Hadigan&rft.aufirst=Colleen&rft.date=2011-07-20&rft.volume=306&rft.issue=3&rft.spage=294&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Chronic infection; Genotypes; Hepatitis; Health care; Human immunodeficiency virus; infection; Hepatitis C virus; USA ER - TY - JOUR T1 - The relationship between serum ghrelin and the risk of gastric and esophagogastric junctional adenocarcinomas. AN - 878595853; 21693726 AB - Cancers of the upper gastrointestinal tract remain a substantial cause of morbidity and mortality worldwide. Ghrelin is a hormone produced in the oxyntic glands of the stomach, and under conditions of chronic inflammation and atrophy, serum ghrelin concentrations decrease. However, the relationship between ghrelin and the risk of gastric and esophagogastric junctional cancers has not been investigated. We conducted a nested case-control study within the Finnish Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study to examine the relationship between serum ghrelin concentration and the risk of gastric noncardia adenocarcinoma (GNCA) and esophagogastric junctional adenocarcinoma (EGJA). Data from 261 GNCA patients, 98 EGJA patients, and 441 control subjects were analyzed. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using logistic regression with adjustment for potential confounders. Lag analysis was also performed to investigate the temporal nature of the associations between baseline serum pepsinogen I and ghrelin in GNCA and EGJA patients. All statistical tests were two-sided. Lower concentrations of serum ghrelin were statistically significantly associated with an increased risk of both GNCA (adjusted OR = 1.75, 95% CI = 1.49 to 2.04; P < .001) and EGJA (adjusted OR = 1.56, 95% CI = 1.28 to 1.89, P < .001). A multivariable model found that the risk of both GNCA and EGJA were statistically significantly increased for those individuals in the lowest quartile of serum ghrelin levels compared with those in the highest quartile (OR of GNCA = 5.63, 95% CI = 3.16 to 10.03; OR of EGJA = 4.90, 95% CI = 2.11 to 11.35). The statistical significance of these associations remained even after restricting the analysis to those patients who developed cancer more than 10 years after baseline serum ghrelin measurements. Low baseline concentrations of serum ghrelin were associated with a statistically significant increase in the risk of GNCA and EGJA, suggesting a potential role for gastric hormones in carcinogenesis. JF - Journal of the National Cancer Institute AU - Murphy, Gwen AU - Kamangar, Farin AU - Dawsey, Sanford M AU - Stanczyk, Frank Z AU - Weinstein, Stephanie J AU - Taylor, Philip R AU - Virtamo, Jarmo AU - Abnet, Christian C AU - Albanes, Demetrius AU - Freedman, Neal D AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 3034, Rockville, MD 20892, USA. murphygw@mail.nih.gov Y1 - 2011/07/20/ PY - 2011 DA - 2011 Jul 20 SP - 1123 EP - 1129 VL - 103 IS - 14 KW - Antibodies, Bacterial KW - 0 KW - Biomarkers, Tumor KW - Ghrelin KW - Pepsinogen A KW - 9001-10-9 KW - Index Medicus KW - Odds Ratio KW - Humans KW - Helicobacter Infections -- complications KW - Aged KW - Radioimmunoassay KW - Risk Assessment KW - Multivariate Analysis KW - Helicobacter pylori -- isolation & purification KW - Prospective Studies KW - Logistic Models KW - Risk Factors KW - Antibodies, Bacterial -- blood KW - Case-Control Studies KW - Enzyme-Linked Immunosorbent Assay KW - Middle Aged KW - Finland -- epidemiology KW - Female KW - Male KW - Stomach Neoplasms -- microbiology KW - Adenocarcinoma -- epidemiology KW - Adenocarcinoma -- blood KW - Adenocarcinoma -- microbiology KW - Ghrelin -- blood KW - Stomach Neoplasms -- blood KW - Pepsinogen A -- blood KW - Esophagogastric Junction KW - Stomach Neoplasms -- epidemiology KW - Biomarkers, Tumor -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878595853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=The+relationship+between+serum+ghrelin+and+the+risk+of+gastric+and+esophagogastric+junctional+adenocarcinomas.&rft.au=Murphy%2C+Gwen%3BKamangar%2C+Farin%3BDawsey%2C+Sanford+M%3BStanczyk%2C+Frank+Z%3BWeinstein%2C+Stephanie+J%3BTaylor%2C+Philip+R%3BVirtamo%2C+Jarmo%3BAbnet%2C+Christian+C%3BAlbanes%2C+Demetrius%3BFreedman%2C+Neal+D&rft.aulast=Murphy&rft.aufirst=Gwen&rft.date=2011-07-20&rft.volume=103&rft.issue=14&rft.spage=1123&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/10.1093%2Fjnci%2Fdjr194 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-07 N1 - Date created - 2011-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1341-7 [16835334] Clin Cancer Res. 2005 Dec 1;11(23):8295-303 [16322288] Nat Rev Cancer. 2006 Dec;6(12):936-46 [17128210] Ann Med. 2007;39(2):116-36 [17453675] Am J Gastroenterol. 2007 Jun;102(6):1166-72 [17378911] Peptides. 2008 Aug;29(8):1369-76 [18471933] Cancer Prev Res (Phila). 2008 Oct;1(5):329-38 [19138977] Gut. 2009 May;58(5):636-42 [19136509] Gastroenterology. 2009 May;136(6):1863-73 [19457415] Surg Oncol. 2010 Mar;19(1):e2-e10 [19328680] Gut. 2010 Jul;59(7):874-81 [20581234] Regul Pept. 2010 Aug 9;163(1-3):7-17 [20382189] Int J Cancer. 2010 Dec 15;127(12):2893-917 [21351269] Scand J Gastroenterol. 2000 Sep;35(9):950-6 [11063155] Circulation. 2001 Oct 23;104(17):2034-8 [11673342] J Biol Chem. 2002 Feb 15;277(7):5667-74 [11724768] J Endocrinol. 2002 Mar;172(3):R7-11 [11874717] Gut. 2003 May;52(5):637-40 [12692045] Biochem Biophys Res Commun. 2003 Sep 19;309(2):464-8 [12951072] Gut. 2004 Feb;53(2):187-94 [14724148] Eur J Endocrinol. 2004 Feb;150(2):173-84 [14763915] Ann N Y Acad Sci. 2004 Apr;1014:1-12 [15153415] J Clin Invest. 2004 Jul;114(1):57-66 [15232612] Hepatogastroenterology. 2004 Sep-Oct;51(59):1249-54 [15362725] Ann Intern Med. 1980 Oct;93(4):537-40 [7436185] Gastroenterology. 1982 Jan;82(1):26-33 [7053333] Clin Chim Acta. 1987 Mar 16;163(2):191-8 [3568423] Cancer Res. 1988 Jul 1;48(13):3554-60 [3288329] Am J Epidemiol. 1988 Sep;128(3):655-66 [2458036] Am J Epidemiol. 1988 Sep;128(3):667-76 [2843041] Ann Epidemiol. 1994 Jan;4(1):1-10 [8205268] Ann Med. 1995 Oct;27(5):569-73 [8541034] Am J Epidemiol. 1996 Jul 15;144(2):142-9 [8678045] Scand J Gastroenterol. 1998 Mar;33(3):294-300 [9548624] Dig Dis Sci. 2005 May;50(5):833-8 [15906753] Am J Gastroenterol. 2005 Aug;100(8):1711-20 [16086706] J Natl Cancer Inst. 2006 Oct 18;98(20):1445-52 [17047193] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jnci/djr194 ER - TY - JOUR T1 - Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer. AN - 878595439; 21685357 AB - Previous studies that were based primarily on small numbers of patients suggested that certain circulating proinflammatory cytokines may be associated with lung cancer; however, large independent studies are lacking. Associations between serum interleukin 6 (IL-6) and interleukin 8 (IL-8) levels and lung cancer were analyzed among 270 case patients and 296 control subjects participating in the National Cancer Institute-Maryland (NCI-MD) case-control study. Results were validated in 532 case patients and 595 control subjects in a nested case-control study within the prospective Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Association with C-reactive protein (CRP), a systemic inflammation biomarker, was also analyzed. Associations between biomarkers and lung cancer were estimated using logistic regression models adjusted for smoking, stage, histology, age, and sex. The 10-year standardized absolute risks of lung cancer were estimated using a weighted Cox regression model. Serum IL-6 and IL-8 levels in the highest quartile were associated with lung cancer in the NCI-MD study (IL-6, odds ratio [OR] = 3.29, 95% confidence interval [CI] = 1.88 to 5.77; IL-8, OR = 2.06, 95% CI = 1.19 to 3.57) and with lung cancer risk in the PLCO study (IL-6, OR = 1.48, 95% CI = 1.04 to 2.10; IL-8, OR = 1.57, 95% CI = 1.10 to 2.24), compared with the lowest quartile. In the PLCO study, increased IL-6 levels were only associated with lung cancer diagnosed within 2 years of blood collection, whereas increased IL-8 levels were associated with lung cancer diagnosed more than 2 years after blood collection (OR = 1.57, 95% CI = 1.15 to 2.13). The 10-year standardized absolute risks of lung cancer in the PLCO study were highest among current smokers with high IL-8 and CRP levels (absolute risk = 8.01%, 95% CI = 5.77% to 11.05%). Although increased levels of both serum IL-6 and IL-8 are associated with lung cancer, only IL-8 levels are associated with lung cancer risk several years before diagnosis. Combination of IL-8 and CRP are more robust biomarkers than either marker alone in predicting subsequent lung cancer. JF - Journal of the National Cancer Institute AU - Pine, Sharon R AU - Mechanic, Leah E AU - Enewold, Lindsey AU - Chaturvedi, Anil K AU - Katki, Hormuzd A AU - Zheng, Yun-Ling AU - Bowman, Elise D AU - Engels, Eric A AU - Caporaso, Neil E AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4258, USA. Y1 - 2011/07/20/ PY - 2011 DA - 2011 Jul 20 SP - 1112 EP - 1122 VL - 103 IS - 14 KW - Biomarkers, Tumor KW - 0 KW - Interleukin-6 KW - Interleukin-8 KW - C-Reactive Protein KW - 9007-41-4 KW - Index Medicus KW - Humans KW - Aged KW - Predictive Value of Tests KW - Research Design KW - Risk Assessment KW - Prospective Studies KW - Logistic Models KW - Risk Factors KW - National Cancer Institute (U.S.) KW - Smoking Cessation KW - Adult KW - Confounding Factors (Epidemiology) KW - Case-Control Studies KW - Middle Aged KW - United States -- epidemiology KW - Time Factors KW - Female KW - Male KW - Proportional Hazards Models KW - Interleukin-6 -- blood KW - Lung Neoplasms -- etiology KW - Lung Neoplasms -- epidemiology KW - Lung Neoplasms -- blood KW - Inflammation -- blood KW - Smoking -- adverse effects KW - Biomarkers, Tumor -- blood KW - Interleukin-8 -- blood KW - C-Reactive Protein -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878595439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Increased+levels+of+circulating+interleukin+6%2C+interleukin+8%2C+C-reactive+protein%2C+and+risk+of+lung+cancer.&rft.au=Pine%2C+Sharon+R%3BMechanic%2C+Leah+E%3BEnewold%2C+Lindsey%3BChaturvedi%2C+Anil+K%3BKatki%2C+Hormuzd+A%3BZheng%2C+Yun-Ling%3BBowman%2C+Elise+D%3BEngels%2C+Eric+A%3BCaporaso%2C+Neil+E%3BHarris%2C+Curtis+C&rft.aulast=Pine&rft.aufirst=Sharon&rft.date=2011-07-20&rft.volume=103&rft.issue=14&rft.spage=1112&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/10.1093%2Fjnci%2Fdjr216 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-07 N1 - Date created - 2011-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Physiol Lung Cell Mol Physiol. 2000 May;278(5):L906-13 [10781420] Pancreas. 2000 Jul;21(1):52-6 [10881932] Control Clin Trials. 2000 Dec;21(6 Suppl):273S-309S [11189684] Cytokine Growth Factor Rev. 2001 Mar;12(1):33-40 [11312117] Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9824-9 [11504947] Int J Cancer. 2002 Jun 10;99(5):673-80 [12115500] Arterioscler Thromb Vasc Biol. 2002 Oct 1;22(10):1668-73 [12377747] Nature. 2002 Dec 19-26;420(6917):860-7 [12490959] J Interferon Cytokine Res. 2002 Nov;22(11):1129-35 [12513912] Carcinogenesis. 2003 Feb;24(2):269-74 [12584177] Vascul Pharmacol. 2002 Aug;39(3):149-54 [12616983] Cytokines Cell Mol Ther. 2002;7(4):151-6 [14660055] Cochrane Database Syst Rev. 2004;(1):CD001991 [14973979] Br J Cancer. 1995 May;71(5):1095-8 [7734307] Neoplasma. 1996;43(3):155-8 [8841501] Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2413-8 [16214925] Cancer Res. 2005 Oct 15;65(20):9566-73 [16230422] Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):381-4 [16492932] Oncology. 2006;70(2):115-25 [16645324] N Engl J Med. 2006 Oct 26;355(17):1763-71 [17065637] J Clin Oncol. 2006 Nov 20;24(33):5216-22 [17114654] Int J Oncol. 2007 Apr;30(4):977-83 [17332938] J Clin Invest. 2007 May;117(5):1175-83 [17476347] J Epidemiol Community Health. 2007 Sep;61(9):824-33 [17699539] J Natl Cancer Inst. 2007 Aug 15;99(16):1257-69 [17686824] Int J Cancer. 2007 Dec 1;121(11):2373-80 [17893866] Expert Rev Anticancer Ther. 2008 Apr;8(4):605-15 [18402527] Cell. 2008 Jun 13;133(6):1019-31 [18555778] Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):215-22 [19124500] J Clin Oncol. 2009 May 1;27(13):2217-24 [19289618] CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49 [19474385] Nat Cell Biol. 2009 Sep;11(9):1135-42 [19701195] J Gerontol A Biol Sci Med Sci. 2010 Apr;65(4):429-33 [20018825] Eur J Cancer. 2010 May;46(7):1223-31 [20335016] Cancer Metastasis Rev. 2010 Jun;29(2):273-83 [20390322] J Clin Oncol. 2010 Jun 1;28(16):2719-26 [20421535] Carcinogenesis. 2010 Oct;31(10):1778-86 [20729390] Pathol Oncol Res. 2011 Mar;17(1):7-10 [20340055] Comment In: J Natl Cancer Inst. 2011 Jul 20;103(14):1073-5 [21685358] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jnci/djr216 ER - TY - CPAPER T1 - caArray: make microarray data easily accessible and exchangeable T2 - 19th Annual International Conference on Intelligent Systems for Molecular Biology and 10th European Conference on Computational Biology (ISMB/ECCB 2011) AN - 1313023563; 6078105 JF - 19th Annual International Conference on Intelligent Systems for Molecular Biology and 10th European Conference on Computational Biology (ISMB/ECCB 2011) AU - Bian, Xiaopeng AU - Klemm, Juli AU - Colbert, Maureen AU - Srinivasa, Rashmi Y1 - 2011/07/17/ PY - 2011 DA - 2011 Jul 17 KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313023563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+and+10th+European+Conference+on+Computational+Biology+%28ISMB%2FECCB+2011%29&rft.atitle=caArray%3A+make+microarray+data+easily+accessible+and+exchangeable&rft.au=Bian%2C+Xiaopeng%3BKlemm%2C+Juli%3BColbert%2C+Maureen%3BSrinivasa%2C+Rashmi&rft.aulast=Bian&rft.aufirst=Xiaopeng&rft.date=2011-07-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+and+10th+European+Conference+on+Computational+Biology+%28ISMB%2FECCB+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismbeccb2011-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Slip symmetry - a new type of symmetry in protein structures T2 - 19th Annual International Conference on Intelligent Systems for Molecular Biology and 10th European Conference on Computational Biology (ISMB/ECCB 2011) AN - 1312983914; 6078298 JF - 19th Annual International Conference on Intelligent Systems for Molecular Biology and 10th European Conference on Computational Biology (ISMB/ECCB 2011) AU - KC, Dukka AU - Taylor, Todd AU - Lee, Byungkook Y1 - 2011/07/17/ PY - 2011 DA - 2011 Jul 17 KW - Protein structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312983914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+and+10th+European+Conference+on+Computational+Biology+%28ISMB%2FECCB+2011%29&rft.atitle=Slip+symmetry+-+a+new+type+of+symmetry+in+protein+structures&rft.au=KC%2C+Dukka%3BTaylor%2C+Todd%3BLee%2C+Byungkook&rft.aulast=KC&rft.aufirst=Dukka&rft.date=2011-07-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+and+10th+European+Conference+on+Computational+Biology+%28ISMB%2FECCB+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismbeccb2011-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Bacterial small RNAs in regulatory networks T2 - 19th Annual International Conference on Intelligent Systems for Molecular Biology and 10th European Conference on Computational Biology (ISMB/ECCB 2011) AN - 1312961831; 6078464 JF - 19th Annual International Conference on Intelligent Systems for Molecular Biology and 10th European Conference on Computational Biology (ISMB/ECCB 2011) AU - Gottesman, Susan Y1 - 2011/07/17/ PY - 2011 DA - 2011 Jul 17 KW - Molecular biology KW - Computer applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312961831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+and+10th+European+Conference+on+Computational+Biology+%28ISMB%2FECCB+2011%29&rft.atitle=Bacterial+small+RNAs+in+regulatory+networks&rft.au=Gottesman%2C+Susan&rft.aulast=Gottesman&rft.aufirst=Susan&rft.date=2011-07-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+and+10th+European+Conference+on+Computational+Biology+%28ISMB%2FECCB+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismbeccb2011-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Predicting the 3d DNA structure of the human genome T2 - 19th Annual International Conference on Intelligent Systems for Molecular Biology and 10th European Conference on Computational Biology (ISMB/ECCB 2011) AN - 1312940294; 6078317 JF - 19th Annual International Conference on Intelligent Systems for Molecular Biology and 10th European Conference on Computational Biology (ISMB/ECCB 2011) AU - Bilke, Sven Y1 - 2011/07/17/ PY - 2011 DA - 2011 Jul 17 KW - Genomes KW - DNA structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312940294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+and+10th+European+Conference+on+Computational+Biology+%28ISMB%2FECCB+2011%29&rft.atitle=Predicting+the+3d+DNA+structure+of+the+human+genome&rft.au=Bilke%2C+Sven&rft.aulast=Bilke&rft.aufirst=Sven&rft.date=2011-07-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+and+10th+European+Conference+on+Computational+Biology+%28ISMB%2FECCB+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismbeccb2011-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Mechanisms of Retrovirus Recombination and RNA Packaging T2 - 30th Annual Meeting of the American Society for Virology (ASV 2011) AN - 1313024227; 6065874 JF - 30th Annual Meeting of the American Society for Virology (ASV 2011) AU - Hu, Wei-Shau Y1 - 2011/07/16/ PY - 2011 DA - 2011 Jul 16 KW - Packaging KW - Retrovirus KW - RNA KW - Recombination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313024227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2011%29&rft.atitle=Mechanisms+of+Retrovirus+Recombination+and+RNA+Packaging&rft.au=Hu%2C+Wei-Shau&rft.aulast=Hu&rft.aufirst=Wei-Shau&rft.date=2011-07-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cce.umn.edu/American-Society-for-Virology-Meeting/Scientific-Program/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Variation in metabolic rate of Anopheles gambiae and A. arabiensis in a Sahelian village AN - 904474385; 15089359 AB - In the Sahel, the Anopheles gambiae complex consists of Anopheles arabiensis and the M and S molecular forms of A. gambiae sensu stricto. However, the composition of these malaria vectors varies spatially and temporally throughout the region and is thought to be linked to environmental factors such as rainfall, larval site characteristics and duration of the dry season. To examine possible physiological divergence between these taxa, we measured metabolic rates of mosquitoes during the wet season in a Sahelian village in Mali. To our knowledge, this study provides the first measurements of metabolic rates of A. gambiae and A. arabiensis in the field. The mean metabolic rate of A. arabiensis was higher than that of M-form A. gambiae when accounting for the effects of female gonotrophic status, temperature and flight activity. However, after accounting for their difference in body size, no significant difference in metabolic rate was found between these two species (whilst all other factors were found to be significant). Thus, body size may be a key character that has diverged in response to ecological differences between these two species. Alternatively, these species may display additional differences in metabolic rate only during the dry season. Overall, our results indicate that changes in behavior and feeding activity provide an effective mechanism for mosquitoes to reduce their metabolic rate, and provide insight into the possible strategies employed by aestivating individuals during the dry season. We hypothesize that female mosquitoes switch to sugar feeding while in dormancy because of elevated metabolism associated with blood digestion. JF - Journal of Experimental Biology AU - Huestis, Diana L AU - Yaro, Alpha S AU - Traore, Adama I AU - Adamou, Abdoulaye AU - Kassogue, Yaya AU - Diallo, Moussa AU - Timbine, Seydou AU - Dao, Adama AU - Lehmann, Tovi AD - Laboratory of Malaria and Vector Research, NIAID, NIH, 12735 Twinbrook Pkwy, Rockville, MD 20852, USA Y1 - 2011/07/15/ PY - 2011 DA - 2011 Jul 15 SP - 2345 EP - 2353 PB - Company of Biologists, 140 Cowley Road Cambridge CB4 0DL UK VL - 214 IS - 14 SN - 0022-0949, 0022-0949 KW - Entomology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Flight activity KW - Mali KW - Rainfall KW - Metabolic rate KW - Malaria KW - Environmental factors KW - Public health KW - Digestion KW - Rainy season KW - Animal metabolism KW - Body size KW - Feeding behavior KW - Dormancy KW - Aquatic insects KW - Abiotic factors KW - Anopheles arabiensis KW - Temperature effects KW - Sugar KW - Feeding KW - Environmental impact KW - Vectors KW - Anopheles gambiae KW - Blood KW - Dry season KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - Q1 08423:Behaviour KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904474385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Biology&rft.atitle=Variation+in+metabolic+rate+of+Anopheles+gambiae+and+A.+arabiensis+in+a+Sahelian+village&rft.au=Huestis%2C+Diana+L%3BYaro%2C+Alpha+S%3BTraore%2C+Adama+I%3BAdamou%2C+Abdoulaye%3BKassogue%2C+Yaya%3BDiallo%2C+Moussa%3BTimbine%2C+Seydou%3BDao%2C+Adama%3BLehmann%2C+Tovi&rft.aulast=Huestis&rft.aufirst=Diana&rft.date=2011-07-15&rft.volume=214&rft.issue=14&rft.spage=2345&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Biology&rft.issn=00220949&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Rainy season; Animal metabolism; Environmental impact; Dormancy; Dry season; Aquatic insects; Abiotic factors; Public health; Temperature effects; Feeding; Flight activity; Sugar; Rainfall; Metabolic rate; Vectors; Malaria; Environmental factors; Digestion; Blood; Body size; Feeding behavior; Anopheles arabiensis; Anopheles gambiae; Mali ER - TY - JOUR T1 - Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative AN - 899142722; 15601651 AB - Recent studies have implicated an N-terminal caspase-6 cleavage product of mutant huntingtin (htt) as an important mediator of toxicity in Huntington's disease (HD). To directly assess the consequences of such fragments on neurologic function, we produced transgenic mice that express a caspase-6 length N-terminal fragment of mutant htt (N586) with both normal (23Q) and disease (82Q) length glutamine repeats. In contrast to mice expressing N586-23Q, mice expressing N586-82Q accumulate large cytoplasmic inclusion bodies that can be visualized with antibodies to epitopes throughout the N586 protein. However, biochemical analyses of aggregated mutant huntingtin in these mice demonstrated that the inclusion bodies are composed largely of a much smaller htt fragment (terminating before residue 115), with lesser amounts of full-length N586-82Q fragments. Mice expressing the N586-82Q fragment show symptoms typical of previously generated mice expressing mutant huntingtin fragments, including failure to maintain weight, small brain weight and reductions in specific mRNAs in the striatum. Uniquely, these N586-82Q mice develop a progressive movement disorder that includes dramatic deficits in motor performance on the rotarod and ataxia. Our findings suggest that caspase-6-derived fragments of mutant htt are capable of inducing novel HD-related phenotypes, but these fragments are not terminal cleavage products as they are subject to further proteolysis. In this scenario, mutant htt fragments derived from caspase 6, or possibly other proteases, could mediate HD pathogenesis via a 'hit and run' type of mechanism in which caspase-6, or other larger N-terminal fragments, mediate a neurotoxic process before being cleaved to a smaller fragment that accumulates pathologically. JF - Human Molecular Genetics AU - Tebbenkamp, Andrew TN AU - Green, Cameron AU - Xu, Guilian AU - Denovan-Wright, Eileen M AU - Rising, Aaron C AU - Fromholt, Susan E AU - Brown, Hilda H AU - Swing, Debbie AU - Mandel, Ronald J AU - Tessarollo, Lino AU - Borchelt, David R AD - 4 Mouse Cancer Genetics Program, Neural Development Section, National Cancer Institute, Frederick, MD 21702, USA, borchelt@mbi.ufl.edu Y1 - 2011/07/15/ PY - 2011 DA - 2011 Jul 15 SP - 2770 EP - 2782 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 20 IS - 14 SN - 0964-6906, 0964-6906 KW - Biotechnology and Bioengineering Abstracts; Toxicology Abstracts; CSA Neurosciences Abstracts; Genetics Abstracts KW - Proteolysis KW - Glutamine KW - Caspase-6 KW - Motor task performance KW - Brain KW - Biochemical analysis KW - Toxicity KW - Transgenic mice KW - mRNA KW - Huntington's disease KW - Antibodies KW - Huntingtin KW - Movement disorders KW - Neostriatum KW - Neurotoxicity KW - Ataxia KW - Inclusion bodies KW - Proteinase KW - Epitopes KW - W 30925:Genetic Engineering KW - N3 11023:Neurogenetics KW - X 24490:Other KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899142722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Molecular+Genetics&rft.atitle=Transgenic+mice+expressing+caspase-6-derived+N-terminal+fragments+of+mutant+huntingtin+develop+neurologic+abnormalities+with+predominant+cytoplasmic+inclusion+pathology+composed+largely+of+a+smaller+proteolytic+derivative&rft.au=Tebbenkamp%2C+Andrew+TN%3BGreen%2C+Cameron%3BXu%2C+Guilian%3BDenovan-Wright%2C+Eileen+M%3BRising%2C+Aaron+C%3BFromholt%2C+Susan+E%3BBrown%2C+Hilda+H%3BSwing%2C+Debbie%3BMandel%2C+Ronald+J%3BTessarollo%2C+Lino%3BBorchelt%2C+David+R&rft.aulast=Tebbenkamp&rft.aufirst=Andrew&rft.date=2011-07-15&rft.volume=20&rft.issue=14&rft.spage=2770&rft.isbn=&rft.btitle=&rft.title=Human+Molecular+Genetics&rft.issn=09646906&rft_id=info:doi/10.1093%2Fhmg%2Fddr176 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2013-08-12 N1 - SubjectsTermNotLitGenreText - Proteolysis; Glutamine; Caspase-6; Motor task performance; Brain; Biochemical analysis; Toxicity; Transgenic mice; mRNA; Huntington's disease; Huntingtin; Antibodies; Movement disorders; Neurotoxicity; Neostriatum; Ataxia; Inclusion bodies; Proteinase; Epitopes DO - http://dx.doi.org/10.1093/hmg/ddr176 ER - TY - JOUR T1 - Probes for narcotic receptor mediated phenomena. 43. Synthesis of the ortho-a and para-a, and improved synthesis and optical resolution of the ortho-b and para-b oxide-bridged phenylmorphans: Compounds with moderate to low opioid-receptor affinity AN - 883043073; 15320523 AB - N-Phenethyl-substituted ortho-a and para-a oxide-bridged phenylmorphans have been obtained through an improved synthesis and their binding affinity examined at the various opioid receptors. Although the N-phenethyl substituent showed much greater affinity for mu - and Kappa -opioid receptors than their N-methyl relatives (e.g., K sub(i = 167 nM and 171 nM at mu - and Kappa -receptors vs 2800 and 7500 nM for the N-methyl ortho-a oxide-bridged phenylmorphan), the a-isomers were not examined further because of their relatively low affinity. The N-phenethyl substituted ortho-b and para-b oxide-bridged phenylmorphans were also synthesized and their enantiomers were obtained using supercritical fluid chromatography. Of the four enantiomers, only the (+)-ortho-b isomer had moderate affinity for mu - and Kappa -receptors (K) sub(i) = 49 and 42 nM, respectively, and it was found to also have moderate mu - and Kappa -opioid antagonist activity in the [ super(35S]GTP- gamma -S assay (K) sub(e) = 31 and 26 nM). JF - Bioorganic and Medicinal Chemistry AU - Li, Feng AU - Folk, John E AU - Cheng, Kejun AU - Kurimura, Muneaki AU - Deck, Jason A AU - Deschamps, Jeffrey R AU - Rothman, Richard B AU - Dersch, Christina M AU - Jacobson, Arthur E AU - Rice, Kenner C AD - Drug Design and Synthesis Section, Chemical Biology Research Branch, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 5625 Fishers Lane, Room 4N03, Bethesda, MD 20892-9415, USA Y1 - 2011/07/15/ PY - 2011 DA - 2011 Jul 15 SP - 4330 EP - 4337 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 19 IS - 14 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Opioid receptors KW - Enantiomers KW - Chromatography KW - Probes KW - Isomers KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883043073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Probes+for+narcotic+receptor+mediated+phenomena.+43.+Synthesis+of+the+ortho-a+and+para-a%2C+and+improved+synthesis+and+optical+resolution+of+the+ortho-b+and+para-b+oxide-bridged+phenylmorphans%3A+Compounds+with+moderate+to+low+opioid-receptor+affinity&rft.au=Li%2C+Feng%3BFolk%2C+John+E%3BCheng%2C+Kejun%3BKurimura%2C+Muneaki%3BDeck%2C+Jason+A%3BDeschamps%2C+Jeffrey+R%3BRothman%2C+Richard+B%3BDersch%2C+Christina+M%3BJacobson%2C+Arthur+E%3BRice%2C+Kenner+C&rft.aulast=Li&rft.aufirst=Feng&rft.date=2011-07-15&rft.volume=19&rft.issue=14&rft.spage=4330&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2011.05.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Opioid receptors; Enantiomers; Chromatography; Probes; Isomers DO - http://dx.doi.org/10.1016/j.bmc.2011.05.035 ER - TY - JOUR T1 - Mapping cortical representations of the rodent forepaw and hindpaw with BOLD fMRI reveals two spatial boundaries AN - 874198697; 15005027 AB - Electrical stimulation of the rat forepaw and hindpaw was employed to study the spatial distribution of BOLD fMRI. Averaging of multiple fMRI sessions significantly improved the spatial stability of the BOLD signal and enabled quantitative determination of the boundaries of the BOLD fMRI maps. The averaged BOLD fMRI signal was distributed unevenly over the extent of the map and the data at the boundaries could be modeled with major and minor spatial components. Comparison of three-dimensional echo-planar imaging (EPI) fMRI at isotropic 300 [micro]m resolution demonstrated that the border locations of the major spatial component of BOLD signal did not overlap between the forepaw and hindpaw maps. Interestingly, the border positions of the minor BOLD fMRI spatial components extended significantly into neighboring representations. Similar results were found for cerebral blood volume (CBV) weighted fMRI obtained using iron oxide particles, suggesting that the minor spatial components may not be due to vascular mislocalization typically associated with BOLD fMRI. Comparison of the BOLD fMRI maps of the forepaw and hindpaw to histological determination of these representations using cytochrome oxidase (CO) staining demonstrated that the major spatial component of the BOLD fMRI activation maps accurately localizes the borders. Finally, 2-3 weeks following peripheral nerve denervation, cortical reorganization/plasticity at the boundaries of somatosensory limb representations in adult rat brain was studied. Denervation of the hindpaw caused a growth in the major component of forepaw representation into the adjacent border of hindpaw representation, such that fitting to two components no longer led to a better fit as compared to using one major component. The border of the representation after plasticity was the same as the border of its minor component in the absence of any plasticity. It is possible that the minor components represent either vascular effects that extend from the real neuronal representations or the neuronal communication between neighboring regions. Either way the results will be useful for studying mechanisms of plasticity that cause alterations in the boundaries of neuronal representations. JF - NeuroImage AU - Goloshevsky, Artem G AU - Wu, Carolyn W-H AU - Dodd, Stephen J AU - Koretsky, Alan P AD - National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, koretskya@ninds.nih.gov Y1 - 2011/07/15/ PY - 2011 DA - 2011 Jul 15 SP - 526 EP - 538 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 57 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Boundaries KW - Functional magnetic resonance imaging KW - W 30910:Imaging KW - N3:11029 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874198697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Mapping+cortical+representations+of+the+rodent+forepaw+and+hindpaw+with+BOLD+fMRI+reveals+two+spatial+boundaries&rft.au=Goloshevsky%2C+Artem+G%3BWu%2C+Carolyn+W-H%3BDodd%2C+Stephen+J%3BKoretsky%2C+Alan+P&rft.aulast=Goloshevsky&rft.aufirst=Artem&rft.date=2011-07-15&rft.volume=57&rft.issue=2&rft.spage=526&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2011.04.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2011.04.002 ER - TY - JOUR T1 - Bioinformatic and Genetic Association Analysis of MicroRNA Target Sites in One-Carbon Metabolism Genes AN - 904476893; 15353632 AB - One-carbon metabolism (OCM) is linked to DNA synthesis and methylation, amino acid metabolism and cell proliferation. OCM dysfunction has been associated with increased risk for various diseases, including cancer and neural tube defects. MicroRNAs (miRNAs) are similar to 22 nt RNA regulators that have been implicated in a wide array of basic cellular processes, such as differentiation and metabolism. Accordingly, mis-regulation of miRNA expression and/or activity can underlie complex disease etiology. We examined the possibility of OCM regulation by miRNAs. Using computational miRNA target prediction methods and Monte-Carlo based statistical analyses, we identified two candidate miRNA "master regulators" (miR-22 and miR-125) and one candidate pair of "master co-regulators" (miR-344-5p/484 and miR-488) that may influence the expression of a significant number of genes involved in OCM. Interestingly, miR-22 and miR-125 are significantly up-regulated in cells grown under low-folate conditions. In a complementary analysis, we identified 15 single nucleotide polymorphisms (SNPs) that are located within predicted miRNA target sites in OCM genes. We genotyped these 15 SNPs in a population of healthy individuals (age 18-28, n=2,506) that was previously phenotyped for various serum metabolites related to OCM. Prior to correction for multiple testing, we detected significant associations between TCblR rs9426 and methylmalonic acid (p = 0.045), total homocysteine levels (tHcy) (p = 0.033), serum B12 (p & 0.0001), holo transcobalamin (p & 0.0001) and total transcobalamin (p & 0.0001); and between MTHFR rs1537514 and red blood cell folate (p & 0.0001). However, upon further genetic analysis, we determined that in each case, a linked missense SNP is the more likely causative variant. Nonetheless, our Monte-Carlo based in silico simulations suggest that miRNAs could play an important role in the regulation of OCM. JF - PLoS ONE AU - Stone, Nicole AU - Pangilinan, Faith AU - Molloy, Anne M AU - Shane, Barry AU - Scott, John M AU - Ueland, Per Magne AU - Mills, James L AU - Kirke, Peader N AU - Sethupathy, Praveen AU - Brody, Lawrence C AD - Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2011/07/12/ PY - 2011 DA - 2011 Jul 12 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 6 IS - 7 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Age KW - Amino acids KW - Association analysis KW - Bioinformatics KW - Cancer KW - Cell proliferation KW - Computer applications KW - DNA biosynthesis KW - DNA methylation KW - Differentiation KW - Erythrocytes KW - Etiology KW - Folic acid KW - Genetic analysis KW - Metabolites KW - Methylenetetrahydrofolate reductase KW - Neural tube defects KW - RNA KW - Single-nucleotide polymorphism KW - Statistical analysis KW - homocysteine KW - miRNA KW - N 14820:DNA Metabolism & Structure KW - W 30960:Bioinformatics & Computer Applications KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904476893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Bioinformatic+and+Genetic+Association+Analysis+of+MicroRNA+Target+Sites+in+One-Carbon+Metabolism+Genes&rft.au=Stone%2C+Nicole%3BPangilinan%2C+Faith%3BMolloy%2C+Anne+M%3BShane%2C+Barry%3BScott%2C+John+M%3BUeland%2C+Per+Magne%3BMills%2C+James+L%3BKirke%2C+Peader+N%3BSethupathy%2C+Praveen%3BBrody%2C+Lawrence+C&rft.aulast=Stone&rft.aufirst=Nicole&rft.date=2011-07-12&rft.volume=6&rft.issue=7&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0021851 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-09-10 N1 - SubjectsTermNotLitGenreText - DNA biosynthesis; Age; Etiology; Association analysis; Amino acids; miRNA; Erythrocytes; Genetic analysis; Statistical analysis; Methylenetetrahydrofolate reductase; Metabolites; Computer applications; Neural tube defects; Cancer; Differentiation; RNA; Single-nucleotide polymorphism; DNA methylation; Bioinformatics; Folic acid; Cell proliferation; homocysteine DO - http://dx.doi.org/10.1371/journal.pone.0021851 ER - TY - JOUR T1 - A joint modeling approach to data with informative cluster size: robustness to the cluster size model. AN - 871965248; 21495060 AB - In many biomedical and epidemiological studies, data are often clustered due to longitudinal follow up or repeated sampling. While in some clustered data the cluster size is pre-determined, in others it may be correlated with the outcome of subunits, resulting in informative cluster size. When the cluster size is informative, standard statistical procedures that ignore cluster size may produce biased estimates. One attractive framework for modeling data with informative cluster size is the joint modeling approach in which a common set of random effects are shared by both the outcome and cluster size models. In addition to making distributional assumptions on the shared random effects, the joint modeling approach needs to specify the cluster size model. Questions arise as to whether the joint modeling approach is robust to misspecification of the cluster size model. In this paper, we studied both asymptotic and finite-sample characteristics of the maximum likelihood estimators in joint models when the cluster size model is misspecified. We found that using an incorrect distribution for the cluster size may induce small to moderate biases, while using a misspecified functional form for the shared random parameter in the cluster size model results in nearly unbiased estimation of outcome model parameters. We also found that there is little efficiency loss under this model misspecification. A developmental toxicity study was used to motivate the research and to demonstrate the findings. Copyright © 2011 John Wiley & Sons, Ltd. JF - Statistics in medicine AU - Chen, Zhen AU - Zhang, Bo AU - Albert, Paul S AD - Biostatistics and Bioinformatics Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, U.S.A. chenzhe@mail.nih.gov Y1 - 2011/07/10/ PY - 2011 DA - 2011 Jul 10 SP - 1825 EP - 1836 VL - 30 IS - 15 KW - Ethylene Glycol KW - FC72KVT52F KW - Index Medicus KW - Animals KW - Pregnancy Outcome -- veterinary KW - Abnormalities, Drug-Induced -- veterinary KW - Linear Models KW - Mice KW - Follow-Up Studies KW - Sample Size KW - Bias (Epidemiology) KW - Epidemiologic Research Design KW - Cluster Analysis KW - Female KW - Pregnancy KW - Organogenesis -- drug effects KW - Ethylene Glycol -- administration & dosage KW - Biomedical Research -- methods KW - Ethylene Glycol -- toxicity KW - Biomedical Research -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/871965248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistics+in+medicine&rft.atitle=A+joint+modeling+approach+to+data+with+informative+cluster+size%3A+robustness+to+the+cluster+size+model.&rft.au=Chen%2C+Zhen%3BZhang%2C+Bo%3BAlbert%2C+Paul+S&rft.aulast=Chen&rft.aufirst=Zhen&rft.date=2011-07-10&rft.volume=30&rft.issue=15&rft.spage=1825&rft.isbn=&rft.btitle=&rft.title=Statistics+in+medicine&rft.issn=1097-0258&rft_id=info:doi/10.1002%2Fsim.4239 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-24 N1 - Date created - 2011-06-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biometrics. 2001 Sep;57(3):795-802 [11550930] Biometrics. 2002 Dec;58(4):742-53 [12495128] Biometrics. 2003 Mar;59(1):36-42 [12762439] Biometrics. 2003 Jun;59(2):420-9 [12926727] Biometrics. 2003 Sep;59(3):521-30 [14601753] Biometrics. 1982 Dec;38(4):963-74 [7168798] Stat Med. 2007 Dec 30;26(30):5473-85 [18058854] Stat Med. 1992 Oct-Nov;11(14-15):1981-2000 [1480884] Biometrics. 1994 Mar;50(1):39-50 [8086614] Stat Med. 1998 May 30;17(10):1137-56 [9618774] Biometrics. 2005 Sep;61(3):862-6; discussion 866-7 [16135040] Biometrics. 2006 Dec;62(4):1037-43 [17156277] Toxicol Appl Pharmacol. 1985 Oct;81(1):113-27 [4049413] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/sim.4239 ER - TY - JOUR T1 - Cancer biology and NuRD: a multifaceted chromatin remodelling complex. AN - 878821295; 21734722 AB - The nucleosome remodelling and histone deacetylase (NuRD; also known as Mi-2) complex regulates gene expression at the level of chromatin. The NuRD complex has been identified - using both genetic and molecular analyses - as a key determinant of differentiation in mouse embryonic stem cells and during development in various model systems. Similar to other chromatin remodellers, such as SWI/SNF and Polycomb complexes, NuRD has also been implicated in the regulation of transcriptional events that are integral to oncogenesis and cancer progression. Emerging molecular details regarding the recruitment of NuRD to specific loci during development, and the modulation of these events in cancer, are used to illustrate how the inappropriate localization of the complex could contribute to tumour biology. JF - Nature reviews. Cancer AU - Lai, Anne Y AU - Wade, Paul A AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina NC 27709, USA. wadep2@niehs.nih.gov Y1 - 2011/07/07/ PY - 2011 DA - 2011 Jul 07 SP - 588 EP - 596 VL - 11 IS - 8 KW - Chromatin KW - 0 KW - DNA-Binding Proteins KW - MBD2 protein KW - Mi-2 Nucleosome Remodeling and Deacetylase Complex KW - EC 3.5.1.98 KW - Index Medicus KW - Animals KW - Promoter Regions, Genetic KW - Genomic Instability KW - DNA Methylation KW - Gene Silencing KW - Humans KW - Chromatin Assembly and Disassembly KW - DNA-Binding Proteins -- genetics KW - Gene Expression Regulation KW - Neoplasms -- drug therapy KW - Neoplasms -- physiopathology KW - Mi-2 Nucleosome Remodeling and Deacetylase Complex -- physiology KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878821295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+reviews.+Cancer&rft.atitle=Cancer+biology+and+NuRD%3A+a+multifaceted+chromatin+remodelling+complex.&rft.au=Lai%2C+Anne+Y%3BWade%2C+Paul+A&rft.aulast=Lai&rft.aufirst=Anne&rft.date=2011-07-07&rft.volume=11&rft.issue=8&rft.spage=588&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Cancer&rft.issn=1474-1768&rft_id=info:doi/10.1038%2Fnrc3091 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-13 N1 - Date created - 2011-07-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2008 Jan 10;27(3):404-8 [17621273] J Mol Cell Cardiol. 2008 Feb;44(2):352-60 [18067919] Nat Rev Mol Cell Biol. 2008 Mar;9(3):206-18 [18292778] Oncogene. 2008 Mar 27;27(14):1971-80 [17922032] Genes Dev. 2008 May 1;22(9):1174-89 [18451107] Structure. 2008 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http://dx.doi.org/10.1038/nrc3091 ER - TY - JOUR T1 - Protection from Obesity and Diabetes by Blockade of TGF- beta /Smad3 Signaling AN - 1020840982; 15320795 AB - Imbalances in glucose and energy homeostasis are at the core of the worldwide epidemic of obesity and diabetes. Here, we illustrate an important role of the TGF- beta /Smad3 signaling pathway in regulating glucose and energy homeostasis. Smad3-deficient mice are protected from diet-induced obesity and diabetes. Interestingly, the metabolic protection is accompanied by Smad3 super(-) super(/) - white adipose tissue acquiring the bioenergetic and gene expression profile of brown fat/skeletal muscle. Smad3 super(-/- adipocytes demonstrate a marked increase in mitochondrial biogenesis, with a corresponding increase in basal respiration, and Smad3 acts as a repressor of PGC-1 alpha expression. We observe significant correlation between TGF- beta 1 levels and adiposity in rodents and humans. Further, systemic blockade of TGF- beta signaling protects mice from obesity, diabetes, and hepatic steatosis. Together, these results demonstrate that TGF- beta signaling regulates glucose tolerance and energy homeostasis and suggest that modulation of TGF- beta activity might be an effective treatment strategy for obesity and diabetes.) JF - Cell Metabolism AU - Yadav, Hariom AU - Quijano, Celia AU - Kamaraju, Anil K AU - Gavrilova, Oksana AU - Malek, Rana AU - Chen, Weiping AU - Zerfas, Patricia AU - Zhigang, Duan AU - Wright, Elizabeth C AU - Stuelten, Christina AU - Sun, Peter AU - Lonning, Scott AU - Skarulis, Monica AU - Sumner, Anne E AU - Finkel, Toren AU - Rane, Sushil G Y1 - 2011/07/06/ PY - 2011 DA - 2011 Jul 06 SP - 67 EP - 79 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 United States VL - 14 IS - 1 SN - 1550-4131, 1550-4131 KW - Physical Education Index KW - Animal subjects KW - Blood glucose KW - Diabetes KW - Fats KW - Football (American) KW - Muscles KW - Obesity KW - Respiration KW - Strategy KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020840982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Metabolism&rft.atitle=Protection+from+Obesity+and+Diabetes+by+Blockade+of+TGF-+beta+%2FSmad3+Signaling&rft.au=Yadav%2C+Hariom%3BQuijano%2C+Celia%3BKamaraju%2C+Anil+K%3BGavrilova%2C+Oksana%3BMalek%2C+Rana%3BChen%2C+Weiping%3BZerfas%2C+Patricia%3BZhigang%2C+Duan%3BWright%2C+Elizabeth+C%3BStuelten%2C+Christina%3BSun%2C+Peter%3BLonning%2C+Scott%3BSkarulis%2C+Monica%3BSumner%2C+Anne+E%3BFinkel%2C+Toren%3BRane%2C+Sushil+G&rft.aulast=Yadav&rft.aufirst=Hariom&rft.date=2011-07-06&rft.volume=14&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Cell+Metabolism&rft.issn=15504131&rft_id=info:doi/10.1016%2Fj.cmet.2011.04.013 LA - English DB - Physical Education Index N1 - Date revised - 2012-06-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Obesity; Respiration; Animal subjects; Strategy; Muscles; Fats; Football (American); Blood glucose; Diabetes DO - http://dx.doi.org/10.1016/j.cmet.2011.04.013 ER - TY - JOUR T1 - Mammalian production of an isotopically enriched outer domain of the HIV-1 gp120 glycoprotein for NMR spectroscopy AN - 923201862; 15396931 AB - NMR spectroscopic characterization of the structure or the dynamics of proteins generally requires the production of samples isotopically enriched in super(15)N, super(13)C, or super(2)H. The bacterial expression systems currently in use to obtain isotopic enrichment, however, cannot produce a number of eukaryotic proteins, especially those that require post-translational modifications such as N-linked glycosylation for proper folding or activity. Here, we report the use of an adenovirus vector-based mammalian expression system to produce isotopically enriched super(15)N or super(15)N/ super(13)C samples of an outer domain variant of the HIV-1 gp120 envelope glycoprotein with 15 sites of N-linked glycosylation. Yields for the super(15)N- and super(15)N/ super(13)C-label ed gp120s after affinity chromatography were 45 and 44 mg/l, respectively, with an average of over 80% isotope incorporation. Recognition of the labeled gp120 by cognate antibodies that recognize complex epitopes showed affinities comparable to the unlabeled protein. NMR spectra, including super(1)H- super(15)N and super(1)H- super(13)C HSQCs, super(15)N-edited NOESY-HSQC, and 3D HNCO, were of high quality, with signal-to-noise consistent with an efficient level of isotope incorporation, and with chemical shift dispersion indicative of a well-folded protein. The exceptional protein yields, good isotope incorporation, and ability to obtain well-folded post-translationally modified proteins make this mammalian system attractive for the production of isotopically enriched eukaryotic proteins for NMR spectroscopy. JF - Journal of Biomolecular NMR AU - Sastry, Mallika AU - Xu, Ling AU - Georgiev, Ivelin S AU - Bewley, Carole A AU - Nabel, Gary J AU - Kwong, Peter D AD - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, MD, 20892-3027, USA, pdkwong@nih.gov Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 197 EP - 207 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 50 IS - 3 SN - 0925-2738, 0925-2738 KW - Microbiology Abstracts B: Bacteriology KW - Isotopes KW - Adenovirus KW - Glycosylation KW - Affinity chromatography KW - Glycoprotein gp120 KW - Antibodies KW - Envelopes KW - Post-translation KW - Magnetic resonance spectroscopy KW - Human immunodeficiency virus 1 KW - N.M.R. KW - Epitopes KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/923201862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+NMR&rft.atitle=Mammalian+production+of+an+isotopically+enriched+outer+domain+of+the+HIV-1+gp120+glycoprotein+for+NMR+spectroscopy&rft.au=Sastry%2C+Mallika%3BXu%2C+Ling%3BGeorgiev%2C+Ivelin+S%3BBewley%2C+Carole+A%3BNabel%2C+Gary+J%3BKwong%2C+Peter+D&rft.aulast=Sastry&rft.aufirst=Mallika&rft.date=2011-07-01&rft.volume=50&rft.issue=3&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+NMR&rft.issn=09252738&rft_id=info:doi/10.1007%2Fs10858-011-9506-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Affinity chromatography; Glycoprotein gp120; Antibodies; Isotopes; Envelopes; Post-translation; Magnetic resonance spectroscopy; N.M.R.; Glycosylation; Epitopes; Human immunodeficiency virus 1; Adenovirus DO - http://dx.doi.org/10.1007/s10858-011-9506-4 ER - TY - JOUR T1 - Methane Found in Well Water Near Fracking Sites AN - 920802496; 16210183 JF - Environmental Health Perspectives AU - Holzman, David C AD - David C. Holzman writes on science, medicine, energy, economics, and cars from Lexington and Wellfleet, MA. His work has appeared in Smithsonian, The Atlantic Monthly, and the Journal of the National Cancer Institute. Y1 - 2011/07/01/ PY - 2011 DA - 2011 Jul 01 SP - a289 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 119 IS - 7 SN - 0091-6765, 0091-6765 KW - Environment Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920802496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Methane+Found+in+Well+Water+Near+Fracking+Sites&rft.au=Holzman%2C+David+C&rft.aulast=Holzman&rft.aufirst=David&rft.date=2011-07-01&rft.volume=119&rft.issue=7&rft.spage=a289&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.119-a289 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2012-02-10 DO - http://dx.doi.org/10.1289/ehp.119-a289 ER - TY - JOUR T1 - Yoga as Therapy in Psychiatric Disorders: Past, Present, and Future AN - 914790625; 201200291 AB - Complementary and alternative medical treatment, yoga therapy in particular, is being increasingly used for treating psychiatric disorders. Although some claim that such a time-tested practice, yoga, does not need validation, standards of contemporary medical practice make it necessary to test these treatments through modern evidence-based research methods. This paper discusses yoga as a therapy in medical and psychiatric disorders, the challenges that it faces in becoming accepted by the general medical community, and directions for future research in this area. Adapted from the source document. JF - Biofeedback AU - Gangadhar, B N AU - Varambally, Shivarama AD - Department of Psychiatry, National Institute of Mental Health and Neurosciences Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 60 EP - 63 PB - Allen Press, Lawrence KS VL - 39 IS - 2 SN - 1081-5937, 1081-5937 KW - yoga therapy, mental health, research, evidence-based methods KW - Yoga KW - Research methods KW - Medical services KW - Evidence based research KW - Psychiatric disorders KW - Medical treatment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/914790625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biofeedback&rft.atitle=Yoga+as+Therapy+in+Psychiatric+Disorders%3A+Past%2C+Present%2C+and+Future&rft.au=Gangadhar%2C+B+N%3BVarambally%2C+Shivarama&rft.aulast=Gangadhar&rft.aufirst=B&rft.date=2011-07-01&rft.volume=39&rft.issue=2&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Biofeedback&rft.issn=10815937&rft_id=info:doi/10.5298%2F1081-5937-39.2.03 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-01-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Yoga; Psychiatric disorders; Evidence based research; Medical treatment; Medical services; Research methods DO - http://dx.doi.org/10.5298/1081-5937-39.2.03 ER - TY - JOUR T1 - Jocelyn Anne Rankin, PhD, FMLA, 1946-2010 AN - 907926199; 201109065 AB - Presents an obituary for Jocelyn Anne Rankin (1946-2010), a medical librarian who was always committed to research and evidence-based librarianship. Rankin served as chief of the Centers for Disease Control and Prevention's Information Center since early 2000. In 1974, she joined the Mercer University School of Medicine to create its medical library which she also headed as director. While at Mercer, she actively lobbied for librarian involvement in problem-based medical education, which she made as the subject of her doctoral research. One of Rankin's important contributions in the field of medical librarianship was her role in the establishment of the Georgia Interactive Network for Medical Information, currently the oldest statewide network of its kind in the United States. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Grefsheim, Suzanne F AU - LaBeause, Jan H AU - Satterthwaite, Rebecca K AD - Division of Library Services, Office of Research Services, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1150 grefshes@mail.nih.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 183 EP - 184 PB - Medical Library Association, Chicago, IL VL - 99 IS - 3 SN - 1536-5050, 1536-5050 KW - USA KW - Librarians KW - Medical libraries KW - Obituaries KW - article KW - 2.11: LIS - BIOGRAPHIES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907926199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=Jocelyn+Anne+Rankin%2C+PhD%2C+FMLA%2C+1946-2010&rft.au=Grefsheim%2C+Suzanne+F%3BLaBeause%2C+Jan+H%3BSatterthwaite%2C+Rebecca+K&rft.aulast=Grefsheim&rft.aufirst=Suzanne&rft.date=2011-07-01&rft.volume=99&rft.issue=3&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/ L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2011-12-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Obituaries; Librarians; Medical libraries; USA ER - TY - JOUR T1 - Is the Informationist a New Role? A Logic Model Analysis AN - 907925797; 201109108 AB - Trained medical librarians have assumed a variety of roles, from biomedical librarian to hospital librarian, health information specialist, liaison librarian, clinical librarian, knowledge manager, and informationist. Regardless of job title, medical librarians have the same general goal: to provide health care information to patrons. One of the more recent roles for medical librarians is that of an informationist, a concept that has generated controversy in the library profession. Some in the field feel it is the same role as the "clinical librarian". Still others think the role and its associated duties are what medical librarians have been doing all along. This article examines whether the informationist concept is a different role from that of the general medical librarian and whether it is new role. To identify the key differences between GMLs and informationists, a logic model was applied to the activities at the National Institutes of Health Library. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Cooper, I Diane AD - NIH Library, National Institutes of Health, 10 Center Drive, Room 1L09H, MSC 1150, Bethesda, MD 20892-1150 cooperd@mail.nih.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 189 EP - 192 PB - Medical Library Association, Chicago, IL VL - 99 IS - 3 SN - 1536-5050, 1536-5050 KW - Librarians KW - Theories KW - Role KW - Medical libraries KW - article KW - 2.14: LIS - TYPES OF STAFF UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907925797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=Is+the+Informationist+a+New+Role%3F+A+Logic+Model+Analysis&rft.au=Cooper%2C+I+Diane&rft.aulast=Cooper&rft.aufirst=I&rft.date=2011-07-01&rft.volume=99&rft.issue=3&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/ L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2011-12-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Librarians; Role; Theories; Medical libraries ER - TY - JOUR T1 - Isothiazolidinone (IZD) as a phosphoryl mimetic in inhibitors of the Yersinia pestis protein tyrosine phosphatase YopH AN - 904491251; 15449695 AB - Isothiazolidinone (IZD) heterocycles can act as effective components of protein tyrosine phosphatase (PTP) inhibitors by simultaneously replicating the binding interactions of both a phosphoryl group and a highly conserved water molecule, as exemplified by the structures of several PTP1B-inhibitor complexes. In the first unambiguous demonstration of IZD interactions with a PTP other than PTP1B, it is shown by X-ray crystallography that the IZD motif binds within the catalytic site of the Yersinia pestis PTP YopH by similarly displacing a highly conserved water molecule. It is also shown that IZD-based bidentate ligands can inhibit YopH in a nonpromiscuous fashion at low micromolar concentrations. Hence, the IZD moiety may represent a useful starting point for the development of YopH inhibitors. JF - Acta Crystallographica Section D AU - Kim, Sung-Eun AU - Bahta, Medhanit AU - Lountos, George T AU - Ulrich, Robert G AU - Burke, Terrence R AU - Waugh, David S AD - Chemical Biology Laboratory, National Cancer Institute at Frederick, PO Box B, Frederick, MD 21702-1201, USA Y1 - 2011/07/01/ PY - 2011 DA - 2011 Jul 01 SP - 639 EP - 645 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 67 IS - 7 SN - 0907-4449, 0907-4449 KW - Microbiology Abstracts B: Bacteriology KW - X-ray crystallography KW - Yersinia pestis KW - Active sites KW - Protein-tyrosine-phosphatase KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904491251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Crystallographica+Section+D&rft.atitle=Isothiazolidinone+%28IZD%29+as+a+phosphoryl+mimetic+in+inhibitors+of+the+Yersinia+pestis+protein+tyrosine+phosphatase+YopH&rft.au=Kim%2C+Sung-Eun%3BBahta%2C+Medhanit%3BLountos%2C+George+T%3BUlrich%2C+Robert+G%3BBurke%2C+Terrence+R%3BWaugh%2C+David+S&rft.aulast=Kim&rft.aufirst=Sung-Eun&rft.date=2011-07-01&rft.volume=67&rft.issue=7&rft.spage=639&rft.isbn=&rft.btitle=&rft.title=Acta+Crystallographica+Section+D&rft.issn=09074449&rft_id=info:doi/10.1107%2FS0907444911018610 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Document feature - figure 0 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - X-ray crystallography; Active sites; Protein-tyrosine-phosphatase; Yersinia pestis DO - http://dx.doi.org/10.1107/S0907444911018610 ER - TY - JOUR T1 - A novel role for PSD-95 in mediating ethanol intoxication, drinking and place preference AN - 902382439; 15811595 AB - The synaptic signaling mechanisms mediating the behavioral effects of ethanol (EtOH) remain poorly understood. Post-synaptic density 95 (PSD-95, SAP-90, Dlg4) is a key orchestrator of N-methyl-D-aspartate receptors (NMDAR) and glutamatergic synapses, which are known to be major sites of EtOH's behavioral actions. However, the potential contribution of PSD-95 to EtOH-related behaviors has not been established. Here, we evaluated knockout (KO) mice lacking PSD-95 for multiple measures of sensitivity to the acute intoxicating effects of EtOH (ataxia, hypothermia, sedation/hypnosis), EtOH drinking under conditions of free access and following deprivation, acquisition and long-term retention of EtOH conditioned place preference (CPP) (and lithium chloride-induced conditioned taste aversion), and intoxication-potentiating responses to NMDAR antagonism. PSD-95 KO exhibited increased sensitivity to the sedative/hypnotic, but not ataxic or hypothermic, effects of acute EtOH relative to wild-type controls (WT). PSD-95 KO consumed less EtOH than WT, particularly at higher EtOH concentrations, although increases in KO drinking could be induced by concentration-fading and deprivation. PSD-95 KO showed normal EtOH CPP 1 day after conditioning, but showed significant aversion 2 weeks later. Lithium chloride-induced taste aversion was impaired in PSD-95 KO at both time points. Finally, the EtOH-potentiating effects of the NMDAR antagonist MK-801 were intact in PSD-95 KO at the dose tested. These data reveal a major, novel role for PSD-95 in mediating EtOH behaviors, and add to growing evidence that PSD-95 is a key mediator of the effects of multiple abused drugs. JF - Addiction Biology AU - Camp, Marguerite C AU - Feyder, Michael AU - Ihne, Jessica AU - Palachick, Benjamin AU - Hurd, Benita AU - Karlsson, Rose-Marie AU - Noronha, Bianca AU - Chen, Yi-Chyan AU - Coba, Marcelo P AU - Grant, Seth G N AU - Holmes, Andrew AD - NIH/NIAAA, Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, USA Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 428 EP - 439 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 16 IS - 3 SN - 1355-6215, 1355-6215 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Intoxication KW - Place preferences KW - Synapses KW - N-Methyl-D-aspartic acid receptors KW - Data processing KW - Postsynaptic density proteins KW - Hypnotics KW - Antagonism KW - Drug abuse KW - Glutamic acid receptors KW - MK-801 KW - Sedatives KW - Glutamatergic transmission KW - Taste aversion KW - Ataxia KW - Drinking behavior KW - Hypnosis KW - Lithium KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902382439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+Biology&rft.atitle=A+novel+role+for+PSD-95+in+mediating+ethanol+intoxication%2C+drinking+and+place+preference&rft.au=Camp%2C+Marguerite+C%3BFeyder%2C+Michael%3BIhne%2C+Jessica%3BPalachick%2C+Benjamin%3BHurd%2C+Benita%3BKarlsson%2C+Rose-Marie%3BNoronha%2C+Bianca%3BChen%2C+Yi-Chyan%3BCoba%2C+Marcelo+P%3BGrant%2C+Seth+G+N%3BHolmes%2C+Andrew&rft.aulast=Camp&rft.aufirst=Marguerite&rft.date=2011-07-01&rft.volume=16&rft.issue=3&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Addiction+Biology&rft.issn=13556215&rft_id=info:doi/10.1111%2Fj.1369-1600.2010.00282.x L2 - http://www.ingentaconnect.com/content/bpl/adb/2011/00000016/00000003/art00007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-10-02 N1 - SubjectsTermNotLitGenreText - Intoxication; Place preferences; N-Methyl-D-aspartic acid receptors; Synapses; Data processing; Postsynaptic density proteins; Hypnotics; Antagonism; Drug abuse; Glutamic acid receptors; MK-801; Glutamatergic transmission; Sedatives; Taste aversion; Ataxia; Drinking behavior; Lithium; Hypnosis; Ethanol DO - http://dx.doi.org/10.1111/j.1369-1600.2010.00282.x ER - TY - JOUR T1 - DEMONSTRATION OF A DOSE ESTIMATION AND RISK ANALYSIS METHOD FOR COMPLEX RADIATION DOSE RECONSTRUCTIONS AN - 902381941; 15691951 AB - Complex dose reconstruction models are often needed to estimate individual doses that arise from exposure to sources of environmental radiation. In such cases, estimates of doses are subject to significant uncertainty due to lack of knowledge of the exact exposure conditions for each individual as well as simplified exposure models that lump numerous physical processes together. Estimation of the epidemiological dose-response from highly uncertain doses can result in a number of misinterpretations including bias of the risk towards the null, distortion of the true shape of the dose-response function, and inadequate characterization of the confidence limits of the slope of the dose-response. A specialized dose reconstruction and risk estimation method is demonstrated here for exposure models and dose estimates with complex error structures: the Two Dimensional Monte Carlo (2DMC) for dose estimation and a Bayesian method for evaluating the dose response. The basic attribute of the 2DMC method is the estimation of multiple sets of dose for the entire cohort with each set internally consistent in terms of inter-individual correlations and possible systematic errors in dosimetry accounted for. The Bayesian method for evaluating the dose response determines the risk and a confidence interval that reflects the goodness-of-fit of the dose response from all sets of cohort doses estimated (typically > 1,000 sets). While variations of these methods have been discussed in the literature, a full demonstration of the 2DMC combined with the Bayesian evaluation of dose response has yet to be presented for an epidemiological study. Here, initial findings from a radiation health risk study underway at the National Cancer Institute are presented. Our findings demonstrate that when complex errors and uncertainties are present, health risk estimates based on the arithmetic mean dose for each person can significantly under-or over-estimate the true risk, depending how different the vector of true doses is from the vector of average doses. Health risk estimated from the 2DMC dose reconstruction and the Bayesian dose response methods successfully reproduced the true risk in a majority of controlled test simulations. Their future application to risk evaluation for complex dosimetry systems appears promising. JF - Health Physics AU - Kwon, D AU - Weinstock, R AU - Hoffman, F AD - National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USA Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 1 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 101 IS - 1 SN - 0017-9078, 0017-9078 KW - Risk Abstracts KW - Risk assessment KW - Monte Carlo simulation KW - Risk analysis KW - Dose-response effects KW - Dosimetry KW - Simulation KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902381941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=DEMONSTRATION+OF+A+DOSE+ESTIMATION+AND+RISK+ANALYSIS+METHOD+FOR+COMPLEX+RADIATION+DOSE+RECONSTRUCTIONS&rft.au=Kwon%2C+D%3BWeinstock%2C+R%3BHoffman%2C+F&rft.aulast=Kwon&rft.aufirst=D&rft.date=2011-07-01&rft.volume=101&rft.issue=1&rft.spage=S58&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2013-08-12 N1 - SubjectsTermNotLitGenreText - Monte Carlo simulation; Risk assessment; Risk analysis; Dose-response effects; Dosimetry; Simulation; Cancer ER - TY - JOUR T1 - Pediatricians' and Family Physicians' Weight-Related Care of Children in the U.S AN - 896191284; 201117097 AB - Background: Few national data exist to assess primary care physicians' (PCPs') clinical practices with regard to childhood obesity. Purpose: To survey pediatricians and family practice physicians regarding their assessment, counseling, and management of diet, physical activity, and weight status among pediatric patients in the primary care setting. Methods: A nationally representative cross-sectional survey of pediatricians and family practice physicians sampled from the American Medical Association (AMA) Masterfile was conducted in 2008 and analyzed in 2010. Outcomes included physicians' self-reported practice behaviors regarding assessments of pediatric patients' weight status, counseling of diet and physical activity, and referrals and follow-ups. Results: Response rate excluding physicians listed as "no-contact" by the AMA was 73.7% among pediatricians and 66.9% among family physicians. Less than 50% of all PCPs assessed BMI percentiles regularly in children. Eighteen percent of all PCPs reported referring children for further evaluation or management. Fifty-eight percent of all PCPs reported never, rarely, or only sometimes tracking patients over time concerning weight or weight-related behaviors. Pediatricians were more likely than family physicians to assess weight status and provide behavioral counseling (p's0.001). Conclusions: Active PCP participation in assessing or managing childhood obesity in the primary care setting appears low relative to the frequency of the problem in the U.S. Interventions to reduce the barriers to physician engagement in the assessment and management of healthy lifestyles are needed to prevent and control childhood obesity. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Huang, Terry T.-K. AU - Borowski, Laurel A AU - Liu, Benmei AU - Galuska, Deborah A AU - Ballard-Barbash, Rachel AU - Yanovski, Susan Z AU - Olster, Deborah H AU - Atienza, Audie A AU - Smith, Ashley Wilder Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 24 EP - 32 PB - Elsevier Science, New York NY VL - 41 IS - 1 SN - 0749-3797, 0749-3797 KW - General practitioners KW - Doctors KW - Primary health care KW - Paediatricians KW - Obese children KW - Children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896191284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Pediatricians%27+and+Family+Physicians%27+Weight-Related+Care+of+Children+in+the+U.S&rft.au=Huang%2C+Terry+T.-K.%3BBorowski%2C+Laurel+A%3BLiu%2C+Benmei%3BGaluska%2C+Deborah+A%3BBallard-Barbash%2C+Rachel%3BYanovski%2C+Susan+Z%3BOlster%2C+Deborah+H%3BAtienza%2C+Audie+A%3BSmith%2C+Ashley+Wilder&rft.aulast=Huang&rft.aufirst=Terry&rft.date=2011-07-01&rft.volume=41&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2011.03.016 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Doctors; Paediatricians; General practitioners; Children; Obese children; Primary health care DO - http://dx.doi.org/10.1016/j.amepre.2011.03.016 ER - TY - JOUR T1 - A Systematic Review of Scales That Measure Attitudes Toward Suicide AN - 896181719; 201117295 AB - Background: Studies on attitudes toward suicide are of great interest to researchers worldwide. Although various instruments have been developed to measure attitudes toward suicide, psychometric properties of these instruments have not been systematically reviewed and organized. Aim: We aimed to identify valid, reliable and feasible attitudinal scales by systematically reviewing published articles on scale development and validation studies. In particular, this study focused on scales used for a wide range of populations to measure multidimensional attitudes toward suicide and related issues. Methods: Electronic searches of two databases, PubMed and PsychInfo, were performed. Scales with unique names were identified and listed after reviewing selected publications, and then evaluated for psychometric properties, multidimensionality and appropriateness for a wide range of populations. Results: A total of 2,210 publications were identified by the first electronic search. In the final review process of the selected publications, three scales -- the Suicide Opinion Questionnaire (SOQ), Suicide Attitude Questionnaire (SUIATT) and Attitudes Toward Suicide (ATTS) -- were identified. Conclusion: Each of these scales has its own characteristics and should be used in accordance with research purposes. [Reprinted by permission of Sage Publications Ltd., copyright holder.] JF - International Journal of Social Psychiatry AU - Kodaka, Manami AU - Postuvan, Vita AU - Inagaki, Masatoshi AU - Yamada, Mitsuhiko AD - Department of Psychogeriatrics, National Institute of Mental Health, National Centre of Neurology and Psychiatry, Tokyo, Japan mkodaka@ncnp.go.jp Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 338 EP - 361 PB - Sage Publications, London UK VL - 57 IS - 4 SN - 0020-7640, 0020-7640 KW - suicide attitude scales psychometric properties systematic review KW - Databases KW - Attitudes KW - Psychometric properties KW - Suicide KW - Publications KW - Validation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896181719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Social+Psychiatry&rft.atitle=A+Systematic+Review+of+Scales+That+Measure+Attitudes+Toward+Suicide&rft.au=Kodaka%2C+Manami%3BPostuvan%2C+Vita%3BInagaki%2C+Masatoshi%3BYamada%2C+Mitsuhiko&rft.aulast=Kodaka&rft.aufirst=Manami&rft.date=2011-07-01&rft.volume=57&rft.issue=4&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Social+Psychiatry&rft.issn=00207640&rft_id=info:doi/10.1177%2F0020764009357399 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Number of references - 55 N1 - Last updated - 2016-09-27 N1 - CODEN - IJSPAG N1 - SubjectsTermNotLitGenreText - Suicide; Attitudes; Publications; Psychometric properties; Databases; Validation DO - http://dx.doi.org/10.1177/0020764009357399 ER - TY - JOUR T1 - Implications for Civilian Postvention Research and Practice AN - 896168073; 201117879 AB - One of six commentaries on an article by Russell B. Carr, "When a Soldier Commits Suicide in Iraq: Impact on Unit and Caregivers". Adapted from the source document. JF - Psychiatry AU - Pearson, Jane AD - Division of Services and Intervention Research, NIMH, Rm 7139, MSC 9635, 6001 Executive Blvd., Bethesda, MD 20892 jp36u@nih.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 118 EP - 120 PB - The Guilford Press VL - 74 IS - 2 SN - 0033-2747, 0033-2747 KW - Soldiers KW - Suicide KW - Iraq KW - Carers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896168073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry&rft.atitle=Implications+for+Civilian+Postvention+Research+and+Practice&rft.au=Pearson%2C+Jane&rft.aulast=Pearson&rft.aufirst=Jane&rft.date=2011-07-01&rft.volume=74&rft.issue=2&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Psychiatry&rft.issn=00332747&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Last updated - 2016-09-27 N1 - CODEN - PSYCAB N1 - SubjectsTermNotLitGenreText - Carers; Soldiers; Suicide; Iraq ER - TY - JOUR T1 - U.S. Primary Care Physicians' Diet-, Physical Activity-, and Weight-Related Care of Adult Patients AN - 896166551; 201118231 AB - Background: Overweight and obesity are substantial problems in the U.S., but few national studies exist on primary care physicians' (PCPs') clinical practices regarding overweight and obesity. Purpose: To profile diet, physical activity, and weight control practice patterns of PCPs who treat adults. Methods: A nationally representative survey of 1211 PCPs sampled from the American Medical Association's Masterfile was conducted in 2008 and analyzed in 2010. Outcomes included PCPs' assessment, counseling, referral, and follow-up of diet, physical activity, and weight control in adult patients with and without chronic disease and PCPs' use of pharmacologic treatments and surgical referrals for overweight and obesity. Results: The survey response rate was 64.5%. Half of PCPs (49%) reported recording BMI regularly. Fewer than 50% reported always providing specific guidance on diet, physical activity, or weight control. Regardless of patients' chronic disease status, 10% of PCPs always referred patients for further evaluation/management and 22% reported always systematically tracking patients over time concerning weight or weight-related behaviors. Overall, PCPs were more likely to counsel on physical activity than on diet or weight control (p's0.05). More than 70% of PCPs reported ever using pharmacologic treatments to treat overweight and 86% had referred for obesity-related surgery. Conclusions: PCPs' assessment and behavioral management of overweight and obesity in adults is at a low level relative to the magnitude of the problem in the U.S. Further research is needed to understand barriers to providing care and to improve physician engagement in tracking and managing healthy lifestyles in U.S. adults. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Smith, Ashley Wilder AU - Borowski, Laurel A AU - Liu, Benmei AU - Galuska, Deborah A AU - Signore, Caroline AU - Klabunde, Carrie AU - Huang, Terry T.-K. AU - Krebs-Smith, Susan M AU - Frank, Erica AU - Pronk, Nico AU - Ballard-Barbash, Rachel AD - Division of Cancer Control and Population Sciences National Cancer Institute, NIH, Bethesda, Maryland smithas@mail.nih.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 33 EP - 42 PB - Elsevier Science, New York NY VL - 41 IS - 1 SN - 0749-3797, 0749-3797 KW - Obesity KW - Doctors KW - Physical activity KW - Primary health care KW - Diet KW - Tracking KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896166551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=U.S.+Primary+Care+Physicians%27+Diet-%2C+Physical+Activity-%2C+and+Weight-Related+Care+of+Adult+Patients&rft.au=Smith%2C+Ashley+Wilder%3BBorowski%2C+Laurel+A%3BLiu%2C+Benmei%3BGaluska%2C+Deborah+A%3BSignore%2C+Caroline%3BKlabunde%2C+Carrie%3BHuang%2C+Terry+T.-K.%3BKrebs-Smith%2C+Susan+M%3BFrank%2C+Erica%3BPronk%2C+Nico%3BBallard-Barbash%2C+Rachel&rft.aulast=Smith&rft.aufirst=Ashley&rft.date=2011-07-01&rft.volume=41&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2011.03.017 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Obesity; Diet; Physical activity; Doctors; Tracking; Primary health care DO - http://dx.doi.org/10.1016/j.amepre.2011.03.017 ER - TY - JOUR T1 - Acquisition and Subsequent Transmission of Borrelia hermsii by the Soft Tick Ornithodoros hermsi AN - 893275644; 15466576 AB - Tick-borne relapsing fever is caused by spirochetes within the genus Borrelia. The hallmark of this disease is recurrent febrile episodes and high spirochete densities in mammalian blood resulting from immune evasion. Between episodes of spirochetemia when bacterial densities are low, it is unknown whether ticks can acquire the spirochetes, become colonized by the bacteria, and subsequently transmit the bacteria once they feed again. We addressed these questions by feeding ticks, Ornithodoros hermsi Wheeler (Acari: Argasidae), daily on an infected mouse during low and high levels of spirochete infections. This study demonstrates that spirochete acquisition by the tick vector can occur during low levels of mammalian infection and that once a spirochetemic threshold is attained within the blood, nearly 100% of ticks become colonized by Borrelia hermsii. JF - Journal of Medical Entomology AU - Lopez, Job E AU - McCoy, Brandi N AU - Krajacich, Benjamin J AU - Schwan, Tom G Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 891 EP - 895 PB - Entomological Society of America, 9301 Annapolis Rd. Lanham MD 20706 United States VL - 48 IS - 4 SN - 0022-2585, 0022-2585 KW - Microbiology Abstracts B: Bacteriology; Entomology Abstracts KW - Blood KW - Disease transmission KW - Feeding KW - Spirochetes KW - Vectors KW - tick-borne diseases KW - Borrelia hermsii KW - Ixodidae KW - Argasidae KW - Acari KW - Ornithodoros KW - J 02410:Animal Diseases KW - Z 05350:Medical, Veterinary, and Agricultural Entomology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893275644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Entomology&rft.atitle=Acquisition+and+Subsequent+Transmission+of+Borrelia+hermsii+by+the+Soft+Tick+Ornithodoros+hermsi&rft.au=Lopez%2C+Job+E%3BMcCoy%2C+Brandi+N%3BKrajacich%2C+Benjamin+J%3BSchwan%2C+Tom+G&rft.aulast=Lopez&rft.aufirst=Job&rft.date=2011-07-01&rft.volume=48&rft.issue=4&rft.spage=891&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Entomology&rft.issn=00222585&rft_id=info:doi/10.1603%2FME10283 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Number of references - 1 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Feeding; Blood; Spirochetes; tick-borne diseases; Vectors; Disease transmission; Borrelia hermsii; Argasidae; Ixodidae; Acari; Ornithodoros DO - http://dx.doi.org/10.1603/ME10283 ER - TY - JOUR T1 - Patients with schizophrenia show increased aversion to angry faces in an associative learning task AN - 887493619; 201115561 AB - Background. We were interested in examining the relationship between socially relevant stimuli and decision processes in patients with schizophrenia. Method. We tested patients with schizophrenia and healthy controls on a stochastically rewarded associative learning task. Participants had to determine, through trial and error, which of two faces was associated with a higher chance of reward: one face was angry, the other happy. Results. Both patients and healthy controls were able to perform the task at above-chance accuracy, and there was no significant difference in overall accuracy between the groups. Both groups also reliably preferred the happy face, such that they selected it more often than the angry face on the basis of the same amount of positive versus negative feedback. However, patients were significantly more averse to the angry face, such that they chose it less often than control participants when the reward feedback strongly supported the angry face as the best choice. Conclusions. Patients show an increased aversion to angry faces, in a task in which they must learn to associate rewards with expressions. Adapted from the source document. JF - Psychological Medicine AU - Evans, S AU - Shergill, S S AU - Chouhan, V AU - Bristow, E AU - Collier, T AU - Averbeck, B B AD - Laboratory of Neuropsychology, National institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 1471 EP - 1479 PB - Cambridge University Press, UK VL - 41 IS - 7 SN - 0033-2917, 0033-2917 KW - Decision making, emotions, faces, reward KW - Schizophrenia KW - Facial expressions KW - Accuracy KW - Rewards KW - Anger KW - Associative learning KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/887493619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Patients+with+schizophrenia+show+increased+aversion+to+angry+faces+in+an+associative+learning+task&rft.au=Evans%2C+S%3BShergill%2C+S+S%3BChouhan%2C+V%3BBristow%2C+E%3BCollier%2C+T%3BAverbeck%2C+B+B&rft.aulast=Evans&rft.aufirst=S&rft.date=2011-07-01&rft.volume=41&rft.issue=7&rft.spage=1471&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291710001960 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Anger; Facial expressions; Schizophrenia; Rewards; Accuracy; Associative learning DO - http://dx.doi.org/10.1017/S0033291710001960 ER - TY - JOUR T1 - Traumatic Brain Injury in Intimate Partner Violence: A Critical Review of Outcomes and Mechanisms AN - 883024712; 15201623 AB - The prevalence of intimate partner violence (IPV) is striking, as are its consequences to the lives of women. The IPV often includes physical assault, which can include injuries to the head and attempted strangulation injuries. Both types of injuries can result in traumatic brain injury (TBI). The TBI sustained during IPV often occurs over time, which can increase the risk for health declines and postconcussive syndrome (PCS). Current studies have identified sequelae of cognitive dysfunction, posttraumatic stress disorder, and depression in women experiencing IPV, yet, most fail to determine the role of TBI in the onset and propagation of these disorders. Although imaging studies indicate functional differences in neuronal activation in IPV, they also have not considered the possibility of TBI contributing to these outcomes. This review highlights the significant gaps in current findings related to neuropsychological complications and medical and psychosocial symptoms that likely result in greater morbidity, as well as the societal costs of failing to acknowledge the association of IPV and TBI in women. JF - Trauma, Violence & Abuse AU - Kwako, Laura E AU - Glass, Nancy AU - Campbell, Jacquelyn AU - Melvin, Kristal C AU - Barr, Taura AU - Gill, Jessica M AD - National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA, laura.kwako@nih.gov Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 115 EP - 126 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 12 IS - 3 SN - 1524-8380, 1524-8380 KW - CSA Neurosciences Abstracts; Risk Abstracts KW - Abuse KW - Aggression KW - Brain KW - Cognitive ability KW - Complications KW - Depression KW - Head KW - Injuries KW - Morbidity KW - Neuroimaging KW - Post-traumatic stress disorder KW - Psychology KW - Reviews KW - Traumatic brain injury KW - Violence KW - complications KW - depression KW - domestic violence KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883024712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trauma%2C+Violence+%26+Abuse&rft.atitle=Traumatic+Brain+Injury+in+Intimate+Partner+Violence%3A+A+Critical+Review+of+Outcomes+and+Mechanisms&rft.au=Kwako%2C+Laura+E%3BGlass%2C+Nancy%3BCampbell%2C+Jacquelyn%3BMelvin%2C+Kristal+C%3BBarr%2C+Taura%3BGill%2C+Jessica+M&rft.aulast=Kwako&rft.aufirst=Laura&rft.date=2011-07-01&rft.volume=12&rft.issue=3&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Trauma%2C+Violence+%26+Abuse&rft.issn=15248380&rft_id=info:doi/10.1177%2F1524838011404251 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Number of references - 92 N1 - Last updated - 2012-09-10 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Depression; Head; Cognitive ability; Complications; Reviews; Aggression; Traumatic brain injury; Post-traumatic stress disorder; Abuse; Morbidity; complications; Injuries; Psychology; Brain; domestic violence; depression; Violence DO - http://dx.doi.org/10.1177/1524838011404251 ER - TY - JOUR T1 - Patterns of alcohol consumption among pregnant African-American women in Washington, DC, USA AN - 883019093; 15214294 AB - Kiely M, Thornberry JS, Bhaskar B, Rodan MF. Patterns of alcohol consumption among pregnant African-American women in Washington, DC, USA. Paediatric and Perinatal Epidemiology 2011; 25: 328-339. The objective of this paper is to describe the patterns and associated behaviours related to alcohol consumption among a selected sample of pregnant women seeking prenatal care in inner city Washington DC. Women receiving prenatal care at one of nine sites completed an anonymous alcohol-screening questionnaire. Questions concerned the amount, type and pattern of alcohol consumption. Women were categorised as at no, low, moderate or high risk for alcohol consumption during pregnancy. For comparisons of risk levels of drinking, bivariate associations were examined using Fisher's exact test. Odds ratios (ORs) and 95% confidence intervals (CIs) were also computed. Although 31% of current/recent drinkers stated that they continued to drink during pregnancy, responses to quantity/frequency questions revealed that 42% continued to do so. Women who were at high compared with moderate risk acknowledged that others were worried about their consumption [OR=4.0, 95% CI 1.5, 10.6], that they drank upon rising [OR=6.7, 95% CI 1.8, 26.9], had a need to reduce drinking [OR=3.2, 95% CI 1.3, 8.1] and in the past 5 years had had fractures [OR=4.2, 95% CI 1.0, 17.8] or a road traffic injury [OR=3.4, 95% CI 1.0, 12.2]. Women in the high/moderate compared with low-risk group were more likely to have been injured in a fight or assault [OR=2.7, 95% CI 1.3, 5.6]. This study validated the usefulness of our questionnaire in identifying women who were at risk for alcohol consumption during pregnancy across a range of consumption levels. Using our screening tool, women were willing to disclose their drinking habits. This low-cost method identifies women appropriate for targeting of interventions. JF - Paediatric and Perinatal Epidemiology AU - Kiely, Michele AU - Thornberry, Jutta S AU - Bhaskar, Brinda AU - Rodan, Margaret F AD - a Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda MD Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 328 EP - 339 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 25 IS - 4 SN - 0269-5022, 0269-5022 KW - Risk Abstracts KW - Alcohol KW - prenatal experience KW - inner cities KW - traffic KW - Injuries KW - intervention KW - Females KW - Ethnic groups KW - Pregnancy KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883019093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Paediatric+and+Perinatal+Epidemiology&rft.atitle=Patterns+of+alcohol+consumption+among+pregnant+African-American+women+in+Washington%2C+DC%2C+USA&rft.au=Kiely%2C+Michele%3BThornberry%2C+Jutta+S%3BBhaskar%2C+Brinda%3BRodan%2C+Margaret+F&rft.aulast=Kiely&rft.aufirst=Michele&rft.date=2011-07-01&rft.volume=25&rft.issue=4&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=Paediatric+and+Perinatal+Epidemiology&rft.issn=02695022&rft_id=info:doi/10.1111%2Fj.1365-3016.2010.01179.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Document feature - figure 1 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Alcohol; inner cities; prenatal experience; traffic; Injuries; intervention; Females; Ethnic groups; Pregnancy DO - http://dx.doi.org/10.1111/j.1365-3016.2010.01179.x ER - TY - JOUR T1 - SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity. AN - 880139459; 21720390 AB - Acetaminophen/paracetamol-induced liver failure--which is induced by the binding of reactive metabolites to mitochondrial proteins and their disruption--is exacerbated by fasting. As fasting promotes SIRT3-mediated mitochondrial-protein deacetylation and acetaminophen metabolites bind to lysine residues, we investigated whether deacetylation predisposes mice to toxic metabolite-mediated disruption of mitochondrial proteins. We show that mitochondrial deacetylase SIRT3(-/-) mice are protected from acetaminophen hepatotoxicity, that mitochondrial aldehyde dehydrogenase 2 is a direct SIRT3 substrate, and that its deacetylation increases acetaminophen toxic-metabolite binding and enzyme inactivation. Thus, protein deacetylation enhances xenobiotic liver injury by modulating the binding of a toxic metabolite to mitochondrial proteins. JF - EMBO reports AU - Lu, Zhongping AU - Bourdi, Mohammed AU - Li, Jian H AU - Aponte, Angel M AU - Chen, Yong AU - Lombard, David B AU - Gucek, Marjan AU - Pohl, Lance R AU - Sack, Michael N AD - Center for Molecular Medicine, NHLBI, National Institutes of Health, Building 10-CRC, Room 5-3150, 10 Center Drive, Bethesda, Maryland 20892, USA. Y1 - 2011/07/01/ PY - 2011 DA - 2011 Jul 01 SP - 840 EP - 846 VL - 12 IS - 8 KW - Benzoquinones KW - 0 KW - Imines KW - Mitochondrial Proteins KW - Sirt3 protein, mouse KW - Acetaminophen KW - 362O9ITL9D KW - ALDH2 protein, mouse KW - EC 1.2.1.3 KW - Aldehyde Dehydrogenase KW - Aldehyde Dehydrogenase, Mitochondrial KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Sirtuin 3 KW - EC 3.5.1.- KW - N-acetyl-4-benzoquinoneimine KW - G6S9BN13TI KW - Index Medicus KW - Animals KW - Liver -- enzymology KW - Mitochondria -- enzymology KW - Benzoquinones -- metabolism KW - Liver -- metabolism KW - Mice KW - Protein Binding KW - Mice, Knockout KW - Acetylation KW - Alanine Transaminase -- blood KW - Liver -- drug effects KW - Mice, Inbred C57BL KW - Mitochondria -- metabolism KW - Mitochondrial Proteins -- metabolism KW - Aldehyde Dehydrogenase -- metabolism KW - Imines -- metabolism KW - Chemical and Drug Induced Liver Injury -- etiology KW - Chemical and Drug Induced Liver Injury -- genetics KW - Sirtuin 3 -- metabolism KW - Sirtuin 3 -- genetics KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/880139459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EMBO+reports&rft.atitle=SIRT3-dependent+deacetylation+exacerbates+acetaminophen+hepatotoxicity.&rft.au=Lu%2C+Zhongping%3BBourdi%2C+Mohammed%3BLi%2C+Jian+H%3BAponte%2C+Angel+M%3BChen%2C+Yong%3BLombard%2C+David+B%3BGucek%2C+Marjan%3BPohl%2C+Lance+R%3BSack%2C+Michael+N&rft.aulast=Lu&rft.aufirst=Zhongping&rft.date=2011-07-01&rft.volume=12&rft.issue=8&rft.spage=840&rft.isbn=&rft.btitle=&rft.title=EMBO+reports&rft.issn=1469-3178&rft_id=info:doi/10.1038%2Fembor.2011.121 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-11 N1 - Date created - 2011-07-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Sci. 2006 Jan;89(1):31-41 [16177235] Drug Metab Rev. 2004 Oct;36(3-4):805-22 [15554248] Mol Cell. 2006 Aug;23(4):607-18 [16916647] Clin Toxicol (Phila). 2006;44(6-7):803-932 [17015284] Cell. 2007 Sep 21;130(6):1095-107 [17889652] Mol Cell. 2008 Aug 22;31(4):449-61 [18722172] Mol Cell Biol. 2008 Oct;28(20):6384-401 [18710944] Ceylon Med J. 2009 Mar;54(1):16-7 [19391450] Aging Cell. 2009 Sep;8(5):604-6 [19594485] Nat Med. 2010 Jan;16(1):10 [20057401] Science. 2010 Feb 19;327(5968):1000-4 [20167786] Free Radic Biol Med. 2010 Oct 15;49(7):1230-7 [20647045] Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17315-20 [20855591] Cell. 2010 Nov 24;143(5):802-12 [21094524] Mol Cell. 2010 Dec 22;40(6):893-904 [21172655] Chem Res Toxicol. 2006 Jan;19(1):102-10 [16411662] Chem Res Toxicol. 2001 Apr;14(4):362-70 [11304124] Toxicol Sci. 2002 Jan;65(1):135-50 [11752693] Drug Metab Dispos. 2003 Dec;31(12):1499-506 [14625346] Hepatology. 2004 Nov;40(5):1170-9 [15486922] Semin Liver Dis. 1990 Nov;10(4):267-78 [2281334] Am J Pathol. 1991 Feb;138(2):359-71 [1992763] Arch Toxicol. 1994;68(2):110-8 [8179480] JAMA. 1994 Dec 21;272(23):1845-50 [7990219] Chem Res Toxicol. 1996 Oct-Nov;9(7):1176-82 [8902274] Toxicol Appl Pharmacol. 1996 Nov;141(1):299-307 [8917703] J Biol Chem. 1998 Jul 10;273(28):17940-53 [9651401] Comment In: EMBO Rep. 2011 Aug;12(8):746-7 [21738223] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/embor.2011.121 ER - TY - JOUR T1 - A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2. AN - 879483162; 21482722 AB - The thyroid hormone receptors (TR) are members of the nuclear hormone receptor (NHR) superfamily that regulate development, growth, and metabolism. Upon ligand binding, TR releases bound corepressors and recruits coactivators to modulate target gene expression. Steroid receptor coactivator 2 (SRC2) is an important coregulator that interacts with TRβ to activate gene transcription. To identify novel inhibitors of the TRβ and SRC2 interaction, the authors performed a quantitative high-throughput screen (qHTS) of a TRβ-SRC2 fluorescence polarization assay against more than 290 000 small molecules. The qHTS assayed compounds at 6 concentrations up to 92 µM to generate titration-response curves and determine the potency and efficacy of all compounds. The qHTS data set enabled the characterization of actives for structure-activity relationships as well as for potential artifacts such as fluorescence interference. Selected qHTS actives were tested in the screening assay using fluoroprobes labeled with Texas Red or fluorescein. The retest identified 19 series and 4 singletons as active in both assays with 40% or greater efficacy, free of compound interference, and not toxic to mammalian cells. Selected compounds were tested as independent samples, and a methylsulfonylnitrobenzoate series inhibited the TRβ-SRC2 interaction with 5 µM IC(50). This series represents a new class of thyroid hormone receptor-coactivator modulators. JF - Journal of biomolecular screening AU - Johnson, Ronald L AU - Hwang, Jong Yeon AU - Arnold, Leggy A AU - Huang, Ruili AU - Wichterman, Jennifer AU - Augustinaite, Indre AU - Austin, Christopher P AU - Inglese, James AU - Guy, R Kiplin AU - Huang, Wenwei AD - NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. rjohnso2@mail.nih.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 618 EP - 627 VL - 16 IS - 6 KW - Nuclear Receptor Coactivator 2 KW - 0 KW - Peptides KW - Small Molecule Libraries KW - Thyroid Hormone Receptors beta KW - Index Medicus KW - Small Molecule Libraries -- pharmacology KW - Cells, Cultured KW - Protein Binding -- drug effects KW - Humans KW - Drug Evaluation, Preclinical KW - Thyroid Hormone Receptors beta -- metabolism KW - Peptides -- chemical synthesis KW - High-Throughput Screening Assays KW - Thyroid Hormone Receptors beta -- antagonists & inhibitors KW - Nuclear Receptor Coactivator 2 -- antagonists & inhibitors KW - Peptides -- metabolism KW - Nuclear Receptor Coactivator 2 -- metabolism KW - Nuclear Receptor Coactivator 2 -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879483162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biomolecular+screening&rft.atitle=A+quantitative+high-throughput+screen+identifies+novel+inhibitors+of+the+interaction+of+thyroid+receptor+beta+with+a+peptide+of+steroid+receptor+coactivator+2.&rft.au=Johnson%2C+Ronald+L%3BHwang%2C+Jong+Yeon%3BArnold%2C+Leggy+A%3BHuang%2C+Ruili%3BWichterman%2C+Jennifer%3BAugustinaite%2C+Indre%3BAustin%2C+Christopher+P%3BInglese%2C+James%3BGuy%2C+R+Kiplin%3BHuang%2C+Wenwei&rft.aulast=Johnson&rft.aufirst=Ronald&rft.date=2011-07-01&rft.volume=16&rft.issue=6&rft.spage=618&rft.isbn=&rft.btitle=&rft.title=Journal+of+biomolecular+screening&rft.issn=1552-454X&rft_id=info:doi/10.1177%2F1087057111402199 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-09 N1 - Date created - 2011-07-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Gene. 2000 Mar 7;245(1):1-11 [10713439] J Biol Chem. 2011 Apr 8;286(14):11895-908 [21321127] J Biomol Screen. 2000 Oct;5(5):297-306 [11080688] Physiol Rev. 2001 Jul;81(3):1097-142 [11427693] Physiol Rev. 2001 Jul;81(3):1269-304 [11427696] J Biomol Screen. 2001 Oct;6(5):275-90 [11689128] Mol Endocrinol. 2003 Sep;17(9):1681-92 [12805412] Methods Enzymol. 2003;364:223-46 [14631848] J Nat Prod. 1989 Mar-Apr;52(2):332-6 [2746259] Nature. 1995 Oct 5;377(6548):397-404 [7566114] Nature. 1995 Oct 5;377(6548):454-7 [7566127] Science. 1995 Nov 24;270(5240):1354-7 [7481822] Nature. 1995 Dec 14;378(6558):690-7 [7501015] Nature. 1997 Jun 12;387(6634):733-6 [9192902] Mol Endocrinol. 1998 Feb;12(2):302-13 [9482670] Genes Dev. 1998 Nov 1;12(21):3343-56 [9808622] J Biomol Screen. 2005 Sep;10(6):581-9 [16103421] J Biol Chem. 2005 Dec 30;280(52):43048-55 [16263725] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Curr Top Med Chem. 2007;7(10):922-7 [17508923] J Med Chem. 2007 Nov 1;50(22):5269-80 [17918822] Mol Endocrinol. 2007 Dec;21(12):2919-28 [17823305] Anal Biochem. 2008 Apr 1;375(1):60-70 [18158907] J Med Chem. 2008 Apr 24;51(8):2363-71 [18363325] Assay Drug Dev Technol. 2008 Oct;6(5):637-57 [19035846] J Biomol Screen. 2009 Feb;14(2):181-93 [19196699] Assay Drug Dev Technol. 2009 Apr;7(2):143-69 [19505231] J Med Chem. 2009 Jul 9;52(13):3892-901 [19469546] Nat Rev Cancer. 2009 Sep;9(9):615-30 [19701241] Annu Rev Physiol. 2010;72:247-72 [20148675] J Biomol Screen. 2010 Mar;15(3):268-78 [20150592] Endocr Rev. 2010 Apr;31(2):139-70 [20051527] Mol Cell Biol. 2000 Nov;20(22):8329-42 [11046130] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/1087057111402199 ER - TY - JOUR T1 - ORGAN-SPECIFIC EXTERNAL DOSE COEFFICIENTS AND PROTECTIVE APRON TRANSMISSION FACTORS FOR HISTORICAL DOSE RECONSTRUCTION FOR MEDICAL PERSONNEL AN - 876250144; 15112369 AB - While radiation absorbed dose (Gy) to the skin or other organs is sometimes estimated for patients from diagnostic radiologic examinations or therapeutic procedures, rarely is occupationally-received radiation absorbed dose to individual organs/tissues estimated for medical personnel; e.g., radiologic technologists or radiologists. Generally, for medical personnel, equivalent or effective radiation doses are estimated for compliance purposes. In the very few cases when organ doses to medical personnel are reconstructed, the data is usually for the purpose of epidemiologic studies; e.g., a study of historical doses and risks to a cohort of about 110,000 radiologic technologists presently underway at the U.S. National Cancer Institute. While ICRP and ICRU have published organ-specific external dose conversion coefficients (DCCs) (i.e., absorbed dose to organs and tissues per unit air kerma and dose equivalent per unit air kerma), those factors have been published primarily for mono-energetic photons at selected energies. This presents two related problems for historical dose reconstruction, both of which are addressed here. It is necessary to derive conversion factor values for (1) continuous distributions of energy typical of diagnostic medical x-rays (bremsstrahlung radiation), and (2) energies of particular radioisotopes used in medical procedures, neither of which are presented in published tables. For derivation of DCCs for bremsstrahlung radiation, combinations of x-ray tube potentials and filtrations were derived for different time periods based on a review of relevant literature. Three peak tube potentials (70 kV, 80 kV, and 90 kV) with four different amounts of beam filtration were determined to be applicable for historic dose reconstruction. The probabilities of these machine settings were assigned to each of the four time periods (earlier than 1949, 1949-1954, 1955-1968, and after 1968). Continuous functions were fit to each set of discrete values of the ICRP/ICRU mono-energetic DCCs and the functions integrated over the air-kerma weighted photon fluence of the 12 defined x-ray spectra. The air kerma-weighted DCCs in this work were developed specifically for an irradiation geometry of anterior to posterior (AP) and for the following tissues: thyroid, breast, ovary, lens of eye, lung, colon, testes, heart, skin (anterior side only), red bone marrow (RBM), and brain. In addition, a series of functional relationships to predict D sub(T) K super(-) sub(a) super(1) values for RBM dependent on body mass index [BMI (kg m super(-2)) = weight per height super(2)] and average photon energy were derived from a published analysis. Factors to account for attenuation of radiation by protective lead aprons were also developed. Because lead protective aprons often worn by radiology personnel not only reduce the intensity of x-ray exposure but also appreciably harden the transmitted fluence of bremsstrahlung x-rays, DCCs were separately calculated for organs possibly protected by lead aprons by considering three cases: no apron, 0.25 mm Pb apron, and 0.5 mm Pb apron. For estimation of organ doses from conducting procedures with radioisotopes, continuous functions of the reported mono-energetic values were developed, and DCCs were derived by estimation of the function at relevant energies. By considering the temporal changes in primary exposure-related parameters (e.g., energy distribution), the derived DCCs and transmission factors presented here allow for more realistic historical dose reconstructions for medical personnel when monitoring badge readings are the primary data on which estimation of an individual's organ doses are based. JF - Health Physics AU - Simon, S L AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD., USA, ssimon@mail.nih.gov Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 13 EP - 27 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 101 IS - 1 SN - 0017-9078, 0017-9078 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Historical account KW - USA KW - Filtration KW - Skin KW - Eye KW - Radioisotopes KW - Organs KW - Medical personnel KW - Lead KW - Cancer KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876250144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=ORGAN-SPECIFIC+EXTERNAL+DOSE+COEFFICIENTS+AND+PROTECTIVE+APRON+TRANSMISSION+FACTORS+FOR+HISTORICAL+DOSE+RECONSTRUCTION+FOR+MEDICAL+PERSONNEL&rft.au=Simon%2C+S+L&rft.aulast=Simon&rft.aufirst=S&rft.date=2011-07-01&rft.volume=101&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0b013e318204a60a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2013-08-12 N1 - SubjectsTermNotLitGenreText - Historical account; Filtration; Skin; Eye; Radioisotopes; Organs; Cancer; Lead; Medical personnel; USA DO - http://dx.doi.org/10.1097/HP.0b013e318204a60a ER - TY - JOUR T1 - Telomere length in peripheral blood and breast cancer risk in a prospective case-cohort analysis: results from the Sister Study AN - 876249634; 15015958 AB - Objective: Telomeres are required for maintaining genomic integrity and may play a role in carcinogenesis. Some, but not all, epidemiologic studies have found that short telomeres in leukocytes are associated with an increased risk of breast cancer. To further elucidate this potential association, we examined telomere length in relation to breast cancer risk in prospectively collected blood samples from the Sister Study, a cohort of women aged 35-74years who have a sister with breast cancer. Methods: We performed a case-cohort analysis comparing incident breast cancer cases (n=342) with a subcohort (n=735), randomly selected from 29,026 participants, enrolled by June 1, 2007. Relative telomere length in peripheral blood cells was estimated using a single-tube monochrome multiplex quantitative PCR assay. Results: No association was observed between telomere length and breast cancer risk. Compared with the longest quartile, hazard ratios (HR) associated with the second, third, and the shortest quartile were 0.91 [95% confidence interval (95% CI): 0.62-1.34], 1.11 (95% CI: 0.77-1.60), and 0.93 (95% CI: 0.64-1.35), respectively. Subgroup analyses by menopausal status, invasiveness, or estrogen receptor status of breast cancer did not reveal evidence of association between telomere length in blood cells and subsequent breast cancer risk. Conclusions: This prospective investigation does not support telomere length in blood cells as a biomarker for breast cancer risk. JF - Cancer Causes & Control AU - Kim, Sangmi AU - Sandler, Dale P AU - Carswell, Gleta AU - Roo, Lisa A AU - Parks, Christine G AU - Cawthon, Richard AU - Weinberg, Clarice R AU - Taylor, Jack A AD - Epidemiology Branch, National Institute of Environmental Health Sciences, PO Box 12233, MD A3-05, 111 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA, kims3@niehs.nih.gov Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 1061 EP - 1066 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 22 IS - 7 SN - 0957-5243, 0957-5243 KW - Biochemistry Abstracts 2: Nucleic Acids; Health & Safety Science Abstracts; Risk Abstracts KW - Bioindicators KW - Breast cancer KW - Cancer KW - H 11000:Diseases/Injuries/Trauma KW - N 14820:DNA Metabolism & Structure KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876249634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Telomere+length+in+peripheral+blood+and+breast+cancer+risk+in+a+prospective+case-cohort+analysis%3A+results+from+the+Sister+Study&rft.au=Kim%2C+Sangmi%3BSandler%2C+Dale+P%3BCarswell%2C+Gleta%3BRoo%2C+Lisa+A%3BParks%2C+Christine+G%3BCawthon%2C+Richard%3BWeinberg%2C+Clarice+R%3BTaylor%2C+Jack+A&rft.aulast=Kim&rft.aufirst=Sangmi&rft.date=2011-07-01&rft.volume=22&rft.issue=7&rft.spage=1061&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9778-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2014-04-03 N1 - SubjectsTermNotLitGenreText - Breast cancer; Cancer DO - http://dx.doi.org/10.1007/s10552-011-9778-8 ER - TY - JOUR T1 - T sub(2=based fiber orientation mapping) AN - 876246149; 14945935 AB - Recent MRI studies at high field have observed that, in certain white matter fiber bundles, the signal in T sub(2-weighted MRI (i.e. MRI sensitized to apparent transverse relaxivity) is dependent on fiber orientation [theta] relative to B) sub(0). In this study, the characteristics of this dependency are quantitatively investigated at 7 T using ex-vivo brain specimens, which allowed a large range of rotation angles to be measured. The data confirm the previously suggested variation of R sub(2 (= 1/T) sub(2)*) with [theta] and also indicate that this dependency takes the shape of a combination of sin2[theta] and sin4[theta] functions, with modulation amplitudes (= Delta R sub(2) reaching 6.44 +/- 0.15 Hz (or Delta T) sub(2) = 2.91 +/- 0.33 ms) in the major fiber bundles of the corpus callosum. This particular dependency can be explained by a model of local, sub-voxel scale magnetic field changes resulting from magnetic susceptibility sources that are anisotropic. As an illustration of a potential use of the orientation dependence of R sub(2, the feasibility of generating fiber orientation maps from R) sub(2) data is investigated. JF - NeuroImage AU - Lee, Jongho AU - Van Gelderen, Peter AU - Kuo, Li-Wei AU - Merkle, Hellmut AU - Silva, Afonso C AU - Duyn, Jeff H AD - Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2011/07/01/ PY - 2011 DA - 2011 Jul 01 SP - 225 EP - 234 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 57 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Anisotropy KW - Fibers KW - W 30910:Imaging KW - N3:11029 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876246149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=T+sub%282%3Dbased+fiber+orientation+mapping%29&rft.au=Lee%2C+Jongho%3BVan+Gelderen%2C+Peter%3BKuo%2C+Li-Wei%3BMerkle%2C+Hellmut%3BSilva%2C+Afonso+C%3BDuyn%2C+Jeff+H&rft.aulast=Lee&rft.aufirst=Jongho&rft.date=2011-07-01&rft.volume=57&rft.issue=1&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2011.04.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Fibers DO - http://dx.doi.org/10.1016/j.neuroimage.2011.04.026 ER - TY - JOUR T1 - Exploratory analysis of kinetic solubility measurements of a small molecule library AN - 876234676; 15125354 AB - Kinetic solubility measurements using prototypical assay buffer conditions are presented for a [not, vert, similar]58,000 member library of small molecules. Analyses of the data based upon physical and calculated properties of each individual molecule were performed and resulting trends were considered in the context of commonly held opinions of how physicochemical properties influence aqueous solubility. We further analyze the data using a decision tree model for solubility prediction and via a multi-dimensional assessment of physicochemical relationships to solubility in the context of specific 'rule-breakers' relative to common dogma. The role of solubility as a determinant of assay outcome is also considered based upon each compound's cross-assay activity score for a collection of publicly available screening results. Further, the role of solubility as a governing factor for colloidal aggregation formation within a specified assay setting is examined and considered as a possible cause of a high cross-assay activity score. The results of this solubility profile should aid chemists during library design and optimization efforts and represent a useful training set for computational solubility prediction. JF - Bioorganic and Medicinal Chemistry AU - Guha, Rajarshi AU - Dexheimer, Thomas S AU - Kestranek, Aimee N AU - Jadhav, Ajit AU - Chervenak, Andrew M AU - Ford, Michael G AU - Simeonov, Anton AU - Roth, Gregory P AU - Thomas, Craig J AD - NIH Chemical Genomics Center, National Human Genome Research Institute, NIH, 9800 Medical Center Drive, MSC 3370 Bethesda, MD 20892-3370, USA Y1 - 2011/07/01/ PY - 2011 DA - 2011 Jul 01 SP - 4127 EP - 4134 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 19 IS - 13 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Solubility KW - Data processing KW - Kinetics KW - Physicochemical properties KW - Computer applications KW - Physical training KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876234676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Exploratory+analysis+of+kinetic+solubility+measurements+of+a+small+molecule+library&rft.au=Guha%2C+Rajarshi%3BDexheimer%2C+Thomas+S%3BKestranek%2C+Aimee+N%3BJadhav%2C+Ajit%3BChervenak%2C+Andrew+M%3BFord%2C+Michael+G%3BSimeonov%2C+Anton%3BRoth%2C+Gregory+P%3BThomas%2C+Craig+J&rft.aulast=Guha&rft.aufirst=Rajarshi&rft.date=2011-07-01&rft.volume=19&rft.issue=13&rft.spage=4127&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2011.05.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Data processing; Solubility; Kinetics; Physicochemical properties; Computer applications; Models; Physical training DO - http://dx.doi.org/10.1016/j.bmc.2011.05.005 ER - TY - JOUR T1 - PET imaging of early response to the tyrosine kinase inhibitor ZD4190 AN - 876234505; 14926534 AB - Purpose: We evaluated noninvasive positron emission tomography (PET) imaging for monitoring tumor response to the VEGFR-2 tyrosine kinase (TK) inhibitor ZD4190 during cancer therapy. Experimental design: Orthotopic MDA-MB-435 tumor-bearing mice were treated with ZD4190 (100mg/kg orally per day for three consecutive days). Tumor growth was monitored by caliper measurement. During the therapeutic period, longitudinal PET scans were acquired using super(18)F-FDG, super(18)F-FLT and super(18)F-FPPRGD2 as imaging tracers to evaluate tumor glucose metabolism, tumor cell proliferation, and angiogenesis, respectively. Imaging metrics were validated by immunohistochemical analysis of Ki67, GLUT-1, F4/80, CD31, murine integrin beta 3, and human integrin alpha v beta 3. Results: Three consecutive daily oral administrations of 100mg/kg of ZD4190 were effective in delaying MDA-MB-435 tumor growth. A significant difference in tumor volume was observed on day 7 between the treatment group and the control group (p<0.01). After the final treatment, tumor growth resumed after a short delay. In the control tumors, super(18)F-FPPRGD2 uptake was stable between days 0 and 7. In ZD4190-treated tumors, super(18)F-FPPRGD2 uptake had decreased significantly relative to baseline by 26.74+/-8.12% (p<0.05) on day 1 and by 41.19+/-6.63% (p<0.01) on day 3, then had returned to baseline on day 7. Tumor uptake of super(18)F-FLT had also decreased on both day 1 and day 3 after initiation of ZD4190 treatment. No significant change in super(18)F-FDG uptake in ZD4190-treated tumors was observed, however, compared with the control group. All of the imaging findings were supported by ex vivo analysis of related biomarkers. Conclusion: The longitudinal imaging results demonstrated the usefulness of quantitative super(18)F-FLT and super(18)F-FPPRGD2 PET imaging in evaluating the early antiproliferative and antiangiogenic effects of ZD4190. The quantification data from the PET imaging were consistent with the pattern of initial growth inhibition with treatment, followed by tumor relapse after treatment cessation. JF - European Journal of Nuclear Medicine and Molecular Imaging AU - Yang, Min AU - Gao, Haokao AU - Yan, Yongjun AU - Sun, Xilin AU - Chen, Kai AU - Quan, Qimeng AU - Lang, Lixin AU - Kiesewetter, Dale AU - Niu, Gang AU - Chen, Xiaoyuan AD - Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), 31 Center Drive, Suite 1C14, Bethesda, MD, 20892-2281, USA Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 1237 EP - 1247 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 38 IS - 7 SN - 1619-7070, 1619-7070 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Oral administration KW - Angiogenesis KW - Glucose metabolism KW - Tumors KW - biomarkers KW - Tumor cells KW - Cancer KW - Tracers KW - Integrins KW - Protein-tyrosine kinase KW - Positron emission tomography KW - Nuclear medicine KW - Vascular endothelial growth factor receptors KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876234505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.atitle=PET+imaging+of+early+response+to+the+tyrosine+kinase+inhibitor+ZD4190&rft.au=Yang%2C+Min%3BGao%2C+Haokao%3BYan%2C+Yongjun%3BSun%2C+Xilin%3BChen%2C+Kai%3BQuan%2C+Qimeng%3BLang%2C+Lixin%3BKiesewetter%2C+Dale%3BNiu%2C+Gang%3BChen%2C+Xiaoyuan&rft.aulast=Yang&rft.aufirst=Min&rft.date=2011-07-01&rft.volume=38&rft.issue=7&rft.spage=1237&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.issn=16197070&rft_id=info:doi/10.1007%2Fs00259-011-1742-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Data processing; Angiogenesis; Oral administration; Tumors; Glucose metabolism; Tumor cells; biomarkers; Cancer; Tracers; Integrins; Protein-tyrosine kinase; Positron emission tomography; Nuclear medicine; Vascular endothelial growth factor receptors DO - http://dx.doi.org/10.1007/s00259-011-1742-z ER - TY - JOUR T1 - Functions of yeast Hsp40 chaperone Sis1p dispensable for prion propagation but important for prion curing and protection from prion toxicity. AN - 876190330; 21555396 AB - Replication of amyloid-based yeast prions [PSI(+)], [URE3], and [PIN(+)] depends on the protein disaggregation machinery that includes Hsp104, Hsp70, and Hsp40 molecular chaperones. Yet, overexpressing Hsp104 cures cells of [PSI(+)] prions. An Hsp70 mutant (Ssa1-21p) antagonizes propagation of [PSI(+)] in a manner resembling elevated Hsp104. The major cytosolic Hsp40 Sis1p is the only Hsp40 required for replication of these prions, but its role in [PSI(+)] curing is unknown. Here we find that all nonessential functional regions of Sis1p are dispensable for [PSI(+)] propagation, suggesting that other Hsp40's might provide Hsp40 functions required for [PSI(+)] replication. Conversely, several Sis1p functions were important for promoting antiprion effects of both Ssa1-21p and Hsp104, which implies a link between the antiprion effects of these chaperones and suggests that Sis1p is a specific Hsp40 important for [PSI(+)] curing. These contrasting findings suggest that the functions of Hsp104 that are important for propagation and elimination of [PSI(+)] are either distinct or specified by different Hsp40's. This work also uncovered a growth inhibition caused by [PSI(+)] when certain functions of Sis1p were absent, suggesting that Sis1p protects cells from cytotoxicity caused by [PSI(+)] prions. JF - Genetics AU - Kirkland, P Aaron AU - Reidy, Michael AU - Masison, Daniel C AD - Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0830, USA. Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 565 EP - 577 VL - 188 IS - 3 KW - HSP40 Heat-Shock Proteins KW - 0 KW - HSP70 Heat-Shock Proteins KW - Heat-Shock Proteins KW - Prions KW - Recombinant Proteins KW - SIS1 protein, S cerevisiae KW - SSA3 protein, S cerevisiae KW - Saccharomyces cerevisiae Proteins KW - HsP104 protein, S cerevisiae KW - 143012-44-6 KW - Index Medicus KW - Microscopy, Fluorescence KW - Gene Expression Regulation, Fungal KW - Polymerase Chain Reaction KW - Blotting, Western KW - Transfection KW - Protein Structure, Tertiary KW - Plasmids KW - Mutation KW - Heat-Shock Proteins -- metabolism KW - Saccharomyces cerevisiae Proteins -- metabolism KW - HSP70 Heat-Shock Proteins -- genetics KW - HSP70 Heat-Shock Proteins -- metabolism KW - Saccharomyces cerevisiae Proteins -- genetics KW - Recombinant Proteins -- genetics KW - Saccharomyces cerevisiae -- genetics KW - Prions -- genetics KW - HSP40 Heat-Shock Proteins -- genetics KW - Saccharomyces cerevisiae -- metabolism KW - Recombinant Proteins -- metabolism KW - Prions -- metabolism KW - HSP40 Heat-Shock Proteins -- metabolism KW - Heat-Shock Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876190330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=Functions+of+yeast+Hsp40+chaperone+Sis1p+dispensable+for+prion+propagation+but+important+for+prion+curing+and+protection+from+prion+toxicity.&rft.au=Kirkland%2C+P+Aaron%3BReidy%2C+Michael%3BMasison%2C+Daniel+C&rft.aulast=Kirkland&rft.aufirst=P&rft.date=2011-07-01&rft.volume=188&rft.issue=3&rft.spage=565&rft.isbn=&rft.btitle=&rft.title=Genetics&rft.issn=1943-2631&rft_id=info:doi/10.1534%2Fgenetics.111.129460 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-17 N1 - Date created - 2011-07-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16596-601 [18955697] Science. 1994 Apr 22;264(5158):566-9 [7909170] Mol Microbiol. 2009 Sep;73(6):1101-14 [19682262] Yeast. 2010 Mar;27(3):167-79 [20014008] Mol Cell Biol. 2010 Jul;30(14):3542-52 [20479121] Mol Microbiol. 2011 Jan;79(2):523-32 [21219467] Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5337-41 [21402947] J Mol Biol. 2011 May 6;408(3):432-48 [21392508] Genetics. 2011 Jun;188(2):339-48 [21467567] Mol Cell Biol. 1999 Dec;19(12):8103-12 [10567536] Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):240-4 [10618402] Mol Cell. 2000 Jan;5(1):163-72 [10678178] Structure. 2000 Aug 15;8(8):799-807 [10997899] Genetics. 2000 Oct;156(2):559-70 [11014806] Mol Cell Biol. 2000 Dec;20(23):8916-22 [11073991] EMBO J. 2001 May 15;20(10):2435-42 [11350932] Curr Microbiol. 2001 Jul;43(1):7-10 [11375656] Mol Microbiol. 2001 Jun;40(6):1357-69 [11442834] J Biol Chem. 2002 Jun 14;277(24):21675-82 [11919183] Methods Enzymol. 2002;350:3-41 [12073320] Genetics. 2003 Feb;163(2):495-506 [12618389] Mol Biol Cell. 2003 Mar;14(3):1172-81 [12631732] Mol Biol Cell. 2004 Feb;15(2):761-73 [14657253] J Biol Chem. 2004 Feb 27;279(9):7378-83 [14668331] EMBO Rep. 2004 Jun;5(6):567-71 [15170475] Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10345-9 [7937953] Science. 1995 May 12;268(5212):880-4 [7754373] EMBO J. 1995 Sep 1;14(17):4365-73 [7556078] J Biol Chem. 1996 Apr 19;271(16):9347-54 [8621599] EMBO J. 1996 Jun 17;15(12):3127-34 [8670813] Genetics. 1996 Dec;144(4):1375-86 [8978027] Genetics. 1997 Oct;147(2):507-19 [9335589] Cell. 1998 Jul 10;94(1):73-82 [9674429] J Biol Chem. 1998 Oct 23;273(43):27824-30 [9774392] Mol Cell Biol. 1999 Nov;19(11):7751-8 [10523664] J Biol Chem. 2005 Jun 17;280(24):22809-18 [15824100] Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10575-80 [16024723] Genetics. 2006 Jun;173(2):611-20 [16582428] EMBO J. 2007 Aug 22;26(16):3794-803 [17673909] Proc Natl Acad Sci U S A. 2008 May 20;105(20):7206-11 [18480252] Genetics. 2008 Jul;179(3):1301-11 [18562668] Arch Biochem Biophys. 2008 Oct 15;478(2):167-74 [18706386] J Bacteriol. 1971 May;106(2):519-22 [5573734] Methods Enzymol. 1987;154:164-75 [3323810] Genetics. 1989 May;122(1):19-27 [2659436] J Cell Biol. 1991 Aug;114(4):609-21 [1869583] J Cell Biol. 1991 Aug;114(4):623-38 [1714460] Genetics. 1991 Jul;128(3):513-20 [1874413] Gene. 1992 Jan 2;110(1):119-22 [1544568] J Biol Chem. 1992 Oct 15;267(29):20927-31 [1400408] J Biol Chem. 1994 Feb 18;269(7):5446-51 [8106526] Mol Cell. 2008 Nov 21;32(4):584-91 [19026788] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1534/genetics.111.129460 ER - TY - JOUR T1 - Molecular diagnostics for pharmacogenomic testing of fluoropyrimidine based-therapy: costs, methods and applications. AN - 874896701; 21504372 AB - Abstract Genetic testing of drug response represents an important goal for targeted therapy. In particular, 5-fluorouracil (5-FU) is the backbone of several chemotherapic protocols for treatment of solid tumors. Unfortunately, in some patients, 5-FU is toxic and causes gastrointestinal and hematologic lesions leading to the suspension of therapy. Some adverse drug responses can be predicted by pharmacogenomics. Recently, several polymorphic traits of different genes involved with 5-FU biotransformation have been reported. Many methods have been used for qualitative and quantitative assessment of the mutational status of these genes, without a precise cost-effectiveness analysis. This article reviews recent findings on the seven germline polymorphic traits of four genes involved in the biotransformation of the 5-FU. In particular, we analyze the most common platforms used to identify the specific genetic alterations and their relative costs. Genotyping can be performed either by custom service laboratories or academic reference laboratories by using either the commercial kits (when available) or "in house" tests. By random selection of 20 certified laboratories out of a total of 71, we estimate that the cost of the analysis/single trait is on average €120.00 as custom genotyping service. "In house" validated tests by PCR-based platforms cost approximately €20.00 per single polimorphism. On the basis of this information, the lab manager can evaluate the advantage and limitations, in terms of costs and applicability, of the most appropriate methods for diagnostics of 5-FU pharmacogenomics tests. JF - Clinical chemistry and laboratory medicine AU - Di Francia, Raffaele AU - Berretta, Massimiliano AU - Catapano, Oriana AU - Canzoniero, Lorella M T AU - Formisano, Luigi AD - Laboratory of Molecular Haematology, National Cancer Institute, Fondazione G. Pascale IRCCS, Naples, Italy. raffaele.difrancia@istitutotumori.na.it Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 1105 EP - 1111 VL - 49 IS - 7 KW - Enzymes KW - 0 KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Genotype KW - Genetic Variation KW - Humans KW - Enzymes -- metabolism KW - Enzymes -- genetics KW - Fluorouracil -- therapeutic use KW - Pharmacogenetics -- economics KW - Fluorouracil -- pharmacology KW - Fluorouracil -- metabolism KW - Molecular Diagnostic Techniques -- economics KW - Pharmacogenetics -- methods KW - Molecular Diagnostic Techniques -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874896701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+chemistry+and+laboratory+medicine&rft.atitle=Molecular+diagnostics+for+pharmacogenomic+testing+of+fluoropyrimidine+based-therapy%3A+costs%2C+methods+and+applications.&rft.au=Di+Francia%2C+Raffaele%3BBerretta%2C+Massimiliano%3BCatapano%2C+Oriana%3BCanzoniero%2C+Lorella+M+T%3BFormisano%2C+Luigi&rft.aulast=Di+Francia&rft.aufirst=Raffaele&rft.date=2011-07-01&rft.volume=49&rft.issue=7&rft.spage=1105&rft.isbn=&rft.btitle=&rft.title=Clinical+chemistry+and+laboratory+medicine&rft.issn=1437-4331&rft_id=info:doi/10.1515%2FCCLM.2011.181 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-24 N1 - Date created - 2011-07-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1515/CCLM.2011.181 ER - TY - JOUR T1 - Gene expression and mutation assessment provide clues of genetic and epigenetic mechanisms in liver tumors of oxazepam-exposed mice. AN - 874486924; 21147764 AB - Liver tumors from a previous National Toxicology Program study were examined using global gene expression and mutation analysis to define the mechanisms of carcinogenesis in mice exposed to oxazepam. Five hepatocellular adenomas and 5 hepatocellular carcinomas from male B6C3F1 mice exposed to 5000 ppm oxazepam and 6 histologically normal liver samples from control animals were examined. One of the major findings in the study was upregulation of the Wnt/β-catenin signaling pathway. Genes that activate β-catenin, such as Sox4, were upregulated, whereas genes that inhibit Wnt signaling, such as APC and Crebbp, were downregulated. In addition, liver tumors from oxazepam-exposed mice displayed β-catenin mutations and increased protein expression of glutamine synthetase, a downstream target in the Wnt signaling pathway. Another important finding in this study was the altered expression of oxidative stress-related genes, specifically increased expression of cytochrome p450 genes, including Cyp1a2 and Cyp2b10, and decreased expression of genes that protect against oxidative stress, such as Sod2 and Cat. Increased oxidative stress was confirmed by measuring isoprostane expression using mass spectrometry. Furthermore, global gene expression identified altered expression of genes that are associated with epigenetic mechanisms of cancer. There was decreased expression of genes that are hypermethylated in human liver cancer, including tumor suppressors APC and Pten. Oxazepam-induced tumors also exhibited decreased expression of genes involved in DNA methylation (Crebbp, Dnmt3b) and histone modification (Sirt1). These data suggest that formation of hepatocellular adenomas and carcinomas in oxazepam-exposed mice involves alteration of the Wnt signaling pathway, oxidative stress, and potential epigenetic alterations. © The Authors 2011 JF - Veterinary pathology AU - Lahousse, S A AU - Hoenerhoff, M AU - Collins, J AU - Ton, T-V T AU - Masinde, T AU - Olson, D AU - Rebolloso, Y AU - Koujitani, T AU - Tomer, K B AU - Hong, H-H L AU - Bucher, J AU - Sills, R C AD - Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 875 EP - 884 VL - 48 IS - 4 KW - Carcinogens KW - 0 KW - Wnt Proteins KW - Oxazepam KW - 6GOW6DWN2A KW - Index Medicus KW - Animals KW - Reproducibility of Results KW - Mice KW - Genome KW - Wnt Proteins -- metabolism KW - Protein Array Analysis KW - Wnt Proteins -- genetics KW - Mice, Inbred Strains KW - Oxidative Stress KW - Polymerase Chain Reaction -- methods KW - Mutation KW - Female KW - Male KW - Signal Transduction KW - Liver Neoplasms, Experimental -- genetics KW - Epigenesis, Genetic -- physiology KW - Oxazepam -- toxicity KW - Liver Neoplasms, Experimental -- pathology KW - Carcinogens -- toxicity KW - Liver Neoplasms, Experimental -- chemically induced KW - Gene Expression Regulation, Neoplastic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874486924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+pathology&rft.atitle=Gene+expression+and+mutation+assessment+provide+clues+of+genetic+and+epigenetic+mechanisms+in+liver+tumors+of+oxazepam-exposed+mice.&rft.au=Lahousse%2C+S+A%3BHoenerhoff%2C+M%3BCollins%2C+J%3BTon%2C+T-V+T%3BMasinde%2C+T%3BOlson%2C+D%3BRebolloso%2C+Y%3BKoujitani%2C+T%3BTomer%2C+K+B%3BHong%2C+H-H+L%3BBucher%2C+J%3BSills%2C+R+C&rft.aulast=Lahousse&rft.aufirst=S&rft.date=2011-07-01&rft.volume=48&rft.issue=4&rft.spage=875&rft.isbn=&rft.btitle=&rft.title=Veterinary+pathology&rft.issn=1544-2217&rft_id=info:doi/10.1177%2F0300985810390019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-28 N1 - Date created - 2011-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0300985810390019 ER - TY - JOUR T1 - Current status of genome-wide association studies in cancer. AN - 874482744; 21678065 AB - Genome-wide association studies in cancer have already identified over 150 regions associated with two dozen specific cancers. Already, a handful of multi-cancer susceptibility regions have been uncovered, providing new insights into perhaps common mechanisms of carcinogenesis. For each new susceptibility allele, investigators now face the arduous task of interrogating each region beginning with fine mapping prior to pursuing the biological basis for the direct association of one or more variants. It appears that there may be a significant number of common alleles that contribute to the heritability of a specific cancer. Since each region confers a small contribution to the risk for cancer, it is daunting to consider any single nucleotide polymorphism (SNP) as a clinical test. Since the complex genomic architecture of each cancer differs, additional genotyping and sequence analysis will be required to comprehensively catalog susceptibility alleles followed by the formidable task of understanding the interactions between genetic regions as well as the environment. It will be critical to assess the applicability of genetic tests in specific clinical settings, such as when to perform screening tests with calculable risks (e.g., biopsies or chemoprevention), before incorporating SNPs into clinical practice. To advance the current genomic observations to the clinical venue, new studies will need to be designed to validate the utility of known genetic variants in assessing risk for cancer as well as its outcomes. JF - Human genetics AU - Chung, Charles C AU - Chanock, Stephen J AD - Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4608, USA. Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 59 EP - 78 VL - 130 IS - 1 KW - Genetic Markers KW - 0 KW - Index Medicus KW - Humans KW - Genetic Predisposition to Disease KW - Neoplasms -- genetics KW - Genome-Wide Association Study UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874482744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+genetics&rft.atitle=Current+status+of+genome-wide+association+studies+in+cancer.&rft.au=Chung%2C+Charles+C%3BChanock%2C+Stephen+J&rft.aulast=Chung&rft.aufirst=Charles&rft.date=2011-07-01&rft.volume=130&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Human+genetics&rft.issn=1432-1203&rft_id=info:doi/10.1007%2Fs00439-011-1030-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-23 N1 - Date created - 2011-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00439-011-1030-9 ER - TY - JOUR T1 - Nitrosative damage to free and zinc-bound cysteine thiols underlies nitric oxide toxicity in wild-type Borrelia burgdorferi. AN - 874020603; 21564333 AB - Borrelia burgdorferi encounters potentially harmful reactive nitrogen species (RNS) throughout its infective cycle. In this study, diethylamine NONOate (DEA/NO) was used to characterize the lethal effects of RNS on B. burgdorferi. RNS produce a variety of DNA lesions in a broad spectrum of microbial pathogens; however, levels of the DNA deamination product, deoxyinosine, and the numbers of apurinic/apyrimidinic (AP) sites were identical in DNA isolated from untreated and DEA/NO-treated B. burgdorferi cells. Strains with mutations in the nucleotide excision repair (NER) pathway genes uvrC or uvrB treated with DEA/NO had significantly higher spontaneous mutation frequencies, increased numbers of AP sites in DNA and reduced survival compared with wild-type controls. Polyunsaturated fatty acids in B. burgdorferi cell membranes, which are susceptible to peroxidation by reactive oxygen species (ROS), were not sensitive to RNS-mediated lipid peroxidation. However, treatment of B. burgdorferi cells with DEA/NO resulted in nitrosative damage to several proteins, including the zinc-dependent glycolytic enzyme fructose-1,6-bisphosphate aldolase (BB0445), the Borrelia oxidative stress regulator (BosR) and neutrophil-activating protein (NapA). Collectively, these data suggested that nitrosative damage to proteins harbouring free or zinc-bound cysteine thiols, rather than DNA or membrane lipids underlies RNS toxicity in wild-type B. burgdorferi. © Published 2011. This article is a US Government work and is in the public domain in the USA. JF - Molecular microbiology AU - Bourret, Travis J AU - Boylan, Julie A AU - Lawrence, Kevin A AU - Gherardini, Frank C AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA. Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 259 EP - 273 VL - 81 IS - 1 KW - Bacterial Proteins KW - 0 KW - Chemokines, CXC KW - NapA protein, Borrelia burgdorferi KW - Sulfhydryl Compounds KW - Trans-Activators KW - cysteine thiolate KW - Nitric Oxide KW - 31C4KY9ESH KW - Fructose-Bisphosphate Aldolase KW - EC 4.1.2.13 KW - Zinc KW - J41CSQ7QDS KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Fructose-Bisphosphate Aldolase -- metabolism KW - Trans-Activators -- metabolism KW - Chemokines, CXC -- metabolism KW - Bacterial Proteins -- metabolism KW - Zinc -- metabolism KW - Nitrosation KW - Nitric Oxide -- toxicity KW - Cysteine -- metabolism KW - Sulfhydryl Compounds -- metabolism KW - Borrelia burgdorferi -- drug effects KW - Cysteine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874020603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=Nitrosative+damage+to+free+and+zinc-bound+cysteine+thiols+underlies+nitric+oxide+toxicity+in+wild-type+Borrelia+burgdorferi.&rft.au=Bourret%2C+Travis+J%3BBoylan%2C+Julie+A%3BLawrence%2C+Kevin+A%3BGherardini%2C+Frank+C&rft.aulast=Bourret&rft.aufirst=Travis&rft.date=2011-07-01&rft.volume=81&rft.issue=1&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=1365-2958&rft_id=info:doi/10.1111%2Fj.1365-2958.2011.07691.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-13 N1 - Date created - 2011-06-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Microbiol. 2009 Feb;71(3):594-612 [19040638] J Bacteriol. 1989 Apr;171(4):2049-55 [2649484] Biochem J. 1999 Nov 15;344 Pt 1:253-8 [10548558] Exp Parasitol. 2000 Feb;94(2):111-20 [10673347] Science. 2000 Jun 2;288(5471):1651-3 [10834845] Science. 1991 Nov 15;254(5034):1001-3 [1948068] FEBS Lett. 1993 Feb 22;318(1):11-6 [8436219] Science. 1993 Apr 23;260(5107):539-41 [8386393] Carcinogenesis. 1994 Mar;15(3):443-7 [8118926] Biochem Biophys Res Commun. 1994 Apr 29;200(2):1105-10 [8179589] FEBS Lett. 1994 Jul 18;348(3):223-7 [8034046] Infect Immun. 1994 Sep;62(9):3663-71 [7520417] Immunol Lett. 1994 May;40(2):139-46 [8088871] J Exp Med. 1994 Dec 1;180(6):2251-7 [7964498] Eur J Biochem. 1995 Jan 15;227(1-2):510-5 [7851430] Chem Res Toxicol. 1996 Jul-Aug;9(5):821-7 [8828916] Carcinogenesis. 1996 Nov;17(11):2501-5 [8968069] FEBS Lett. 1997 Mar 17;405(1):37-41 [9094420] Nature. 1997 Dec 11;390(6660):580-6 [9403685] Antimicrob Agents Chemother. 1999 Feb;43(2):403-5 [9925545] Mutat Res. 1999 Mar 8;424(1-2):37-49 [10064848] J Biol Chem. 2005 Mar 11;280(10):8850-4 [15632138] Infect Immun. 2005 Aug;73(8):4581-7 [16040969] Mol Microbiol. 2006 Jan;59(2):475-86 [16390443] Microbiology. 2006 Sep;152(Pt 9):2599-609 [16946255] Arch Biochem Biophys. 2007 Dec 15;468(2):217-25 [17977509] Nat Rev Drug Discov. 2008 Feb;7(2):156-67 [18167491] Mol Microbiol. 2008 May;68(3):786-99 [18373524] PLoS One. 2008;3(4):e1976 [18398486] J Biol Chem. 2008 Jun 6;283(23):15515-9 [18285326] Mol Microbiol. 2009 Dec;74(6):1331-43 [19889086] Mol Microbiol. 2009 Dec;74(6):1344-55 [19906179] Microb Pathog. 2010 Dec;49(6):323-9 [20705129] FEMS Microbiol Lett. 2011 Apr;317(2):172-80 [21272060] Nitric Oxide. 2001 Aug;5(4):289-95 [11485367] Sci STKE. 2001 Jun 12;2001(86):pl1 [11752655] Infect Immun. 2002 Apr;70(4):2139-50 [11895980] J Infect Dis. 2002 Mar 15;185(6):797-804 [11920297] Cell. 2002 May 3;109(3):383-96 [12015987] FEMS Microbiol Lett. 2002 Jul 16;213(1):121-6 [12127498] J Bacteriol. 2003 Jan;185(1):221-30 [12486059] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8496-501 [12829799] Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11684-9 [12975527] J Bacteriol. 2003 Nov;185(22):6723-7 [14594849] Science. 2003 Dec 12;302(5652):1963-6 [14671303] Nat Rev Microbiol. 2004 Oct;2(10):820-32 [15378046] Infect Immun. 1984 Jul;45(1):94-100 [6735474] Carcinogenesis. 1988 Mar;9(3):365-72 [3345578] Infect Immun. 2010 Jan;78(1):265-74 [19858309] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2958.2011.07691.x ER - TY - JOUR T1 - Design, synthesis and biological assessment of novel N-substituted 3-(phthalimidin-2-yl)-2,6-dioxopiperidines and 3-substituted 2,6-dioxopiperidines for TNF-α inhibitory activity. AN - 873705080; 21658960 AB - Eight novel 2-(2,6-dioxopiperidin-3-yl)phthalimidine EM-12 dithiocarbamates 9 and 10, N-substituted 3-(phthalimidin-2-yl)-2,6-dioxopiperidines 11-14 and 3-substituted 2,6-dioxopiperidines 16 and 18 were synthesized as tumor necrosis factor-α (TNF-α) synthesis inhibitors. Synthesis involved utilization of a novel condensation approach, a one-pot reaction involving addition, iminium rearrangement and elimination, to generate the phthalimidine ring required for the creation of compounds 9-14. Agents were, thereafter, quantitatively assessed for their ability to suppress the synthesis on TNF-α in a lipopolysaccharide (LPS)-challenged mouse macrophage-like cellular screen, utilizing cultured RAW 264.7 cells. Whereas compounds 9, 14 and 16 exhibited potent TNF-α lowering activity, reducing TNF-α by up to 48% at 30 μM, compounds 12, 17 and 18 presented moderate TNF-α inhibitory action. The TNF-α lowering properties of these analogs proved more potent than that of revlimid (3) and thalidomide (1). In particular, N-dithiophthalimidomethyl-3-(phthalimidin-2-yl)-2,6-dioxopiperidine 14 not only possessed the greatest potency of the analogs to reduce TNF-α synthesis, but achieved this with minor cellular toxicity at 30 μM. The pharmacological focus of the presented compounds is towards the development of well-tolerated agents to ameliorate the neuroinflammation, that is, commonly associated with neurodegenerative disorders, epitomized by Alzheimer's disease and Parkinson's disease. Copyright © 2011. Published by Elsevier Ltd. JF - Bioorganic & medicinal chemistry AU - Luo, Weiming AU - Yu, Qian-sheng AU - Salcedo, Isidro AU - Holloway, Harold W AU - Lahiri, Debomoy K AU - Brossi, Arnold AU - Tweedie, David AU - Greig, Nigel H AD - Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2011/07/01/ PY - 2011 DA - 2011 Jul 01 SP - 3965 EP - 3972 VL - 19 IS - 13 KW - Phthalimides KW - 0 KW - Piperidines KW - Tumor Necrosis Factor-alpha KW - Thalidomide KW - 4Z8R6ORS6L KW - phthalimidine KW - 51938-01-3 KW - lenalidomide KW - F0P408N6V4 KW - Index Medicus KW - Animals KW - Mice KW - Cell Line, Tumor KW - Drug Design KW - Piperidines -- chemical synthesis KW - Thalidomide -- chemical synthesis KW - Piperidines -- chemistry KW - Piperidines -- toxicity KW - Tumor Necrosis Factor-alpha -- antagonists & inhibitors KW - Thalidomide -- toxicity KW - Thalidomide -- chemistry KW - Tumor Necrosis Factor-alpha -- metabolism KW - Phthalimides -- chemistry KW - Thalidomide -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/873705080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry&rft.atitle=Design%2C+synthesis+and+biological+assessment+of+novel+N-substituted+3-%28phthalimidin-2-yl%29-2%2C6-dioxopiperidines+and+3-substituted+2%2C6-dioxopiperidines+for+TNF-%CE%B1+inhibitory+activity.&rft.au=Luo%2C+Weiming%3BYu%2C+Qian-sheng%3BSalcedo%2C+Isidro%3BHolloway%2C+Harold+W%3BLahiri%2C+Debomoy+K%3BBrossi%2C+Arnold%3BTweedie%2C+David%3BGreig%2C+Nigel+H&rft.aulast=Luo&rft.aufirst=Weiming&rft.date=2011-07-01&rft.volume=19&rft.issue=13&rft.spage=3965&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry&rft.issn=1464-3391&rft_id=info:doi/10.1016%2Fj.bmc.2011.05.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-17 N1 - Date created - 2011-06-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bmc.2011.05.029 ER - TY - JOUR T1 - Chronic dietary supplementation with turmeric protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-mediated neurotoxicity in vivo: implications for Parkinson's disease. AN - 872438694; 21473798 AB - Multiple pathways including oxidative stress and mitochondrial damage are implicated in neurodegeneration during Parkinson's disease (PD). The current PD drugs provide only symptomatic relief and have limitations in terms of adverse effects and inability to prevent neurodegeneration. Therefore, there is a demand for novel compound(s)/products that could target multiple pathways and protect the dying midbrain dopaminergic neurons, with potential utility as adjunctive therapy along with conventional drugs. Turmeric is a spice used in traditional Indian cuisine and medicine with antioxidant, anti-inflammatory and potential neuroprotective properties. To explore the neuroprotective property of turmeric in PD, mice were subjected to dietary supplementation with aqueous suspensions of turmeric for 3 months, mimicking its chronic consumption and challenged in vivo with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Brain samples from untreated and treated groups were characterised based on mitochondrial complex I (CI) activity, protein nitration and tyrosine hydroxylase immunoreactivity. Chronic turmeric supplementation induced the enzyme activity of γ-glutamyl cysteine ligase, which in turn increased glutathione levels and protected against peroxynitrite-mediated inhibition of brain CI. These mice were also protected against MPTP-mediated protein nitration, CI inhibition and degeneration of substantia nigra neurons in the brain. We conclude that chronic dietary consumption of turmeric protects the brain against neurotoxic insults, with potential application in neurodegeneration. Further characterisation of the active constituents of turmeric that potentially promote neuroprotection could improve the utility of dietary turmeric in brain function and disease. JF - The British journal of nutrition AU - Mythri, Rajeswara Babu AU - Veena, Jayagopalan AU - Harish, G AU - Shankaranarayana Rao, B S AU - Srinivas Bharath, M M AD - Department of Neurochemistry, National Institute of Mental Health and Neurosciences, PB No. 2900, Hosur Road, Bangalore 560 029, Karnataka, India. Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 63 EP - 72 VL - 106 IS - 1 KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - Index Medicus KW - Animals KW - Substantia Nigra -- pathology KW - Mice, Inbred C57BL KW - Substantia Nigra -- drug effects KW - Mice KW - Diet KW - Male KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine -- adverse effects KW - MPTP Poisoning -- prevention & control KW - Curcuma KW - Parkinson Disease -- prevention & control KW - Dietary Supplements UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872438694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+journal+of+nutrition&rft.atitle=Chronic+dietary+supplementation+with+turmeric+protects+against+1-methyl-4-phenyl-1%2C2%2C3%2C6-tetrahydropyridine-mediated+neurotoxicity+in+vivo%3A+implications+for+Parkinson%27s+disease.&rft.au=Mythri%2C+Rajeswara+Babu%3BVeena%2C+Jayagopalan%3BHarish%2C+G%3BShankaranarayana+Rao%2C+B+S%3BSrinivas+Bharath%2C+M+M&rft.aulast=Mythri&rft.aufirst=Rajeswara&rft.date=2011-07-01&rft.volume=106&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=The+British+journal+of+nutrition&rft.issn=1475-2662&rft_id=info:doi/10.1017%2FS0007114510005817 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-25 N1 - Date created - 2011-06-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1017/S0007114510005817 ER - TY - JOUR T1 - Time-dependent changes in the brain arachidonic acid cascade during cuprizone-induced demyelination and remyelination. AN - 870551935; 21530210 AB - Phospholipases A(2) (PLA(2)) are the enzymatic keys for the activation of the arachidonic acid (AA) cascade and the subsequent synthesis of pro-inflammatory prostanoids (prostaglandins and tromboxanes). Prostanoids play critical roles in the initiation and modulation of inflammation and their levels have been reported increased in several neurological and neurodegenerative disorders, including multiple sclerosis (MS). Here, we aimed to determine whether brain expression PLA(2) enzymes and the terminal prostagland in levels are changed during cuprizone-induced demyelination and in the subsequent remyelination phase. Mice were given the neurotoxicant cuprizone through the diet for six weeks to induce brain demyelination. Then, cuprizone was withdrawn and mice were returned to a normal diet for 6 weeks to allow spontaneous remyelination. We found that after 4-6 weeks of cuprizone, sPLA(2)(V) and cPLA(2), but not iPLA(2)(VI), gene expression was upregulated in the cortex, concomitant with an increase in the expression of astrocyte and microglia markers. Cyclooxygenase (COX)-2 gene expression was consistently upregulated during all the demyelination period, whereas COX-1 sporadically increased only at week 5 of cuprizone exposure. However, we found that at the protein level only sPLA(2)(V) and COX-1 were elevated during demyelination, with COX-1 selectively expressed by activated and infiltrated microglia/macrophages and astrocytes. Levels of PGE(2), PGD(2), PGI(2) and TXB(2) were also increased during demyelination. During remyelination, none of the PLA(2) isoforms was significantly changed, whereas COX-1 and -2 were sporadically upregulated only at the gene expression level. PGE(2), PGI(2) and PGD(2) levels returned to normal, whereas TXB(2) was still upregulated after 3 weeks of cuprizone withdrawal. Our study characterizes for the first time time-dependent changes in the AA metabolic pathway during cuprizone-induced demyelination and the subsequent remyelination and suggests that sPLA(2)(V) is the major isoform contributing to AA release. Published by Elsevier Ltd. JF - Prostaglandins, leukotrienes, and essential fatty acids AU - Palumbo, S AU - Toscano, C D AU - Parente, L AU - Weigert, R AU - Bosetti, F AD - National Institute on Aging, National Institutes of Health, Brain Physiology and Metabolism Section, Bethesda, MD 20892-0947, USA. Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 29 EP - 35 VL - 85 IS - 1 KW - Arachidonic Acids KW - 0 KW - Membrane Proteins KW - Nerve Tissue Proteins KW - RNA, Messenger KW - Cuprizone KW - 5N16U7E0AO KW - Ptgs2 protein, mouse KW - EC 1.14.99.- KW - Cyclooxygenase 1 KW - EC 1.14.99.1 KW - Cyclooxygenase 2 KW - Ptgs1 protein, mouse KW - Group V Phospholipases A2 KW - EC 3.1.1.4 KW - Phospholipases A2, Cytosolic KW - Pla2g5 protein, mouse KW - Index Medicus KW - Animals KW - Macrophages -- immunology KW - Cyclooxygenase 1 -- metabolism KW - Phospholipases A2, Cytosolic -- metabolism KW - Neurons -- drug effects KW - Astrocytes -- drug effects KW - Membrane Proteins -- genetics KW - Macrophages -- drug effects KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Cyclooxygenase 2 -- metabolism KW - Multiple Sclerosis -- immunology KW - Time Factors KW - Astrocytes -- pathology KW - Male KW - Macrophages -- metabolism KW - Microglia -- metabolism KW - Neurons -- metabolism KW - Cyclooxygenase 2 -- genetics KW - Membrane Proteins -- metabolism KW - Cyclooxygenase 1 -- genetics KW - Mice KW - Multiple Sclerosis -- pathology KW - Astrocytes -- immunology KW - Phospholipases A2, Cytosolic -- genetics KW - Multiple Sclerosis -- metabolism KW - Macrophages -- pathology KW - RNA, Messenger -- metabolism KW - Microglia -- immunology KW - Mice, Inbred C57BL KW - Neurons -- immunology KW - Microglia -- drug effects KW - Microglia -- pathology KW - Astrocytes -- metabolism KW - Group V Phospholipases A2 -- genetics KW - Cerebral Cortex -- drug effects KW - Cerebral Cortex -- immunology KW - Cuprizone -- toxicity KW - Cerebral Cortex -- metabolism KW - Demyelinating Diseases -- immunology KW - Demyelinating Diseases -- metabolism KW - Arachidonic Acids -- metabolism KW - Demyelinating Diseases -- chemically induced KW - Cerebral Cortex -- pathology KW - Myelin Sheath -- drug effects KW - Myelin Sheath -- immunology KW - Nerve Tissue Proteins -- metabolism KW - Myelin Sheath -- metabolism KW - Group V Phospholipases A2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/870551935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Prostaglandins%2C+leukotrienes%2C+and+essential+fatty+acids&rft.atitle=Time-dependent+changes+in+the+brain+arachidonic+acid+cascade+during+cuprizone-induced+demyelination+and+remyelination.&rft.au=Palumbo%2C+S%3BToscano%2C+C+D%3BParente%2C+L%3BWeigert%2C+R%3BBosetti%2C+F&rft.aulast=Palumbo&rft.aufirst=S&rft.date=2011-07-01&rft.volume=85&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Prostaglandins%2C+leukotrienes%2C+and+essential+fatty+acids&rft.issn=1532-2823&rft_id=info:doi/10.1016%2Fj.plefa.2011.04.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-27 N1 - Date created - 2011-06-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Glia. 2008 Apr 15;56(6):686-98 [18293407] J Neurochem. 2007 Oct;103(1):1-16 [17561938] J Neuroinflammation. 2008;5:17 [18489773] J Neuroimmunol. 2008 Nov 15;204(1-2):29-37 [18829119] Brain. 2009 May;132(Pt 5):1221-35 [19218359] Brain Res. 2009 Aug 4;1283:127-38 [19524552] Neurochem Res. 2010 Sep;35(9):1422-33 [20544279] Anaesthesia. 2000 May;55(5):442-9 [10792135] Inflamm Res. 2000 Aug;49(8):367-92 [11028754] Brain Pathol. 2001 Jan;11(1):107-16 [11145196] Methods. 2001 Dec;25(4):402-8 [11846609] Brain Behav Immun. 2002 Oct;16(5):533-43 [12401467] Glia. 2003 Dec;44(3):275-82 [14603468] Neuron. 2004 Feb 5;41(3):323-35 [14766173] Cell Mol Life Sci. 2004 May;61(9):1082-94 [15112055] J Med Chem. 2004 Jul 1;47(14):3615-28 [15214789] Methods Enzymol. 1981;72:5-7 [7311848] Neurology. 1986 Dec;36(12):1587-90 [3785673] Brain Res. 1990 May 7;515(1-2):79-86 [2357580] Neurology. 1991 Feb;41(2 ( Pt 1)):322-4 [1992386] Neurochem Res. 1995 Nov;20(11):1335-43 [8786820] J Neuroimmunol. 1998 Dec 1;92(1-2):38-49 [9916878] J Exp Med. 2005 Sep 19;202(6):841-51 [16172261] Brain. 2006 Aug;129(Pt 8):1984-92 [16835249] Pharmacol Rev. 2006 Sep;58(3):375-88 [16968946] Genome Biol. 2007;8(1):R14 [17266762] Brain Res Bull. 2007 Jun 15;73(1-3):108-13 [17499644] J Neuroimmunol. 2007 May;186(1-2):94-103 [17442406] Subcell Biochem. 2007;42:3-27 [17612044] J Neurochem. 2007 Aug;102(3):577-86 [17403135] FASEB J. 2008 May;22(5):1491-501 [18162486] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.plefa.2011.04.001 ER - TY - JOUR T1 - Interleukin (IL)-1 and IL-6 regulation of neural progenitor cell proliferation with hippocampal injury: differential regulatory pathways in the subgranular zone (SGZ) of the adolescent and mature mouse brain. AN - 870548235; 20833246 AB - Current data suggests an association between elevations in interleukin 1 (IL-1)α, IL-1β, and IL-6 and the proliferation of neural progenitor cells (NPCs) following brain injury. A limited amount of work implicates changes in these pro-inflammatory responses with diminished NPC proliferation observed as a function of aging. In the current study, adolescent (21day-old) and 1year-old CD-1 male mice were injected with trimethyltin (TMT, 2.3mg/kg, i.p.) to produce acute apoptosis of hippocampal dentate granule cells. In this model, fewer 5-bromo-2'-deoxyuridine (BrdU)+ NPC were observed in both naive and injured adult hippocampus as compared to the corresponding number seen in adolescent mice. At 48h post-TMT, a similar level of neuronal death was observed across ages, yet activated ameboid microglia were observed in the adolescent and hypertrophic process-bearing microglia in the adult. IL-1α mRNA levels were elevated in the adolescent hippocampus; IL-6 mRNA levels were elevated in the adult. In subgranular zone (SGZ) isolated by laser-capture microdissection, IL-1β was detected but not elevated by TMT, IL-1a was elevated at both ages, while IL-6 was elevated only in the adult. Naïve NPCs isolated from the hippocampus expressed transcripts for IL-1R1, IL-6Rα, and gp130 with significantly higher levels of IL-6Rα mRNA in the adult. In vitro, IL-1α (150pg/ml) stimulated proliferation of adolescent NPCs; IL-6 (10ng/ml) inhibited proliferation of adolescent and adult NPCs. Microarray analysis of SGZ post-TMT indicated a prominence of IL-1a/IL-1R1 signaling in the adolescent and IL-6/gp130 signaling in the adult. Published by Elsevier Inc. JF - Brain, behavior, and immunity AU - McPherson, C A AU - Aoyama, M AU - Harry, G J AD - Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, USA. Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 850 EP - 862 VL - 25 IS - 5 KW - Interleukin-1 KW - 0 KW - Interleukin-1alpha KW - Interleukin-6 KW - Interleukin-6 Receptor alpha Subunit KW - Receptors, Interleukin-1 Type I KW - Cytokine Receptor gp130 KW - 133483-10-0 KW - Index Medicus KW - Animals KW - Apoptosis -- physiology KW - Interleukin-6 Receptor alpha Subunit -- physiology KW - Astrocytes -- physiology KW - Mice KW - Cell Proliferation KW - Receptors, Interleukin-1 Type I -- physiology KW - Aging -- physiology KW - Cytokine Receptor gp130 -- physiology KW - Signal Transduction -- physiology KW - Microglia -- physiology KW - Interleukin-1alpha -- physiology KW - Male KW - Interleukin-1 -- physiology KW - Interleukin-6 -- physiology KW - Hippocampus -- physiology KW - Hippocampus -- injuries KW - Neural Stem Cells -- physiology KW - Hippocampus -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/870548235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain%2C+behavior%2C+and+immunity&rft.atitle=Interleukin+%28IL%29-1+and+IL-6+regulation+of+neural+progenitor+cell+proliferation+with+hippocampal+injury%3A+differential+regulatory+pathways+in+the+subgranular+zone+%28SGZ%29+of+the+adolescent+and+mature+mouse+brain.&rft.au=McPherson%2C+C+A%3BAoyama%2C+M%3BHarry%2C+G+J&rft.aulast=McPherson&rft.aufirst=C&rft.date=2011-07-01&rft.volume=25&rft.issue=5&rft.spage=850&rft.isbn=&rft.btitle=&rft.title=Brain%2C+behavior%2C+and+immunity&rft.issn=1090-2139&rft_id=info:doi/10.1016%2Fj.bbi.2010.09.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-12 N1 - Date created - 2011-06-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Neurosci. 2007 Feb;25(3):649-58 [17328769] Cytokine Growth Factor Rev. 2007 Oct-Dec;18(5-6):511-8 [17683973] Mol Cell Neurosci. 2007 Nov;36(3):343-54 [17822921] Mol Cell Neurosci. 2008 Jan;37(1):110-8 [17933551] Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):751-6 [18178625] Br J Pharmacol. 2008 Feb;153(4):775-83 [18059318] J Neurosci. 2008 May 14;28(20):5240-7 [18480280] Int J Med Sci. 2008;5(3):127-32 [18566676] Neuroimmunomodulation. 2008;15(4-6):323-30 [19047808] Mol Biol Cell. 2009 Jan;20(1):188-99 [18971377] Neuroscience. 2009 Feb 6;158(3):1021-9 [18662748] Brain Res. 2008 Feb 15;1194:8-20 [18191113] Eur J Neurosci. 2008 Feb;27(3):549-58 [18279308] Aging Cell. 2008 Mar;7(2):207-24 [18241325] J Neurosci Res. 2008 May 1;86(6):1199-208 [18058947] Stem Cells. 2008 Apr;26(4):988-96 [18218818] J Neuroimmunol. 2009 May 29;210(1-2):3-12 [19269040] Stem Cells. 2009 Aug;27(8):2044-52 [19544415] Neurobiol Aging. 2010 Jan;31(1):151-61 [18455269] CNS Neurol Disord Drug Targets. 2010 Apr;9(2):174-91 [20205642] J Neurochem. 2010 Mar;112(6):1368-85 [20028453] J Neurochem. 2010 May;113(4):1060-72 [20236219] World J Gastroenterol. 2010 May 14;16(18):2252-9 [20458762] Synapse. 2010 Sep;64(9):721-8 [20336624] J Neuropathol Exp Neurol. 2010 Aug;69(8):838-49 [20613633] Neurotox Res. 2011 Feb;19(2):341-52 [20524106] Hippocampus. 2011 Jun;21(6):631-46 [20333732] Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13632-7 [14581618] Glia. 2004 Jan 1;45(1):96-104 [14648550] Science. 2003 Dec 5;302(5651):1760-5 [14615545] Biochem Biophys Res Commun. 2004 Mar 5;315(2):493-6 [14766235] Neuropsychopharmacology. 2004 Mar;29(3):450-60 [14872203] Neuron. 2004 Mar 4;41(5):683-6 [15003168] Neurotox Res. 2004;5(8):623-7 [15111239] J Comp Neurol. 1975 Jan 15;159(2):149-75 [1112911] Neuroscience. 1990;39(1):151-70 [2089275] Neurosci Lett. 1992 Mar 2;136(2):189-92 [1641189] Neuroscience. 1994 Jul;61(2):203-9 [7969902] J Biol Chem. 1995 Jun 9;270(23):13757-65 [7775431] J Neuroimmunol. 1995 Dec 31;63(2):113-23 [8550808] J Neurosci. 1996 Mar 15;16(6):2027-33 [8604047] J Biol Chem. 1997 Mar 21;272(12):7727-31 [9065432] J Leukoc Biol. 1998 Jun;63(6):650-7 [9620655] Biochem J. 1998 Sep 1;334 ( Pt 2):297-314 [9716487] J Neurochem. 1998 Oct;71(4):1577-87 [9751191] J Neuroimmunol. 1999 Jan 1;93(1-2):139-48 [10378877] Microsc Res Tech. 1999 Jun 15;45(6):359-82 [10402264] Neuroscience. 1999;93(3):915-30 [10473257] Neurobiol Aging. 2005 Mar;26(3):349-54 [15639313] J Interferon Cytokine Res. 2005 May;25(5):241-53 [15871661] Nat Neurosci. 2005 Jun;8(6):752-8 [15895084] Science. 2005 May 27;308(5726):1314-8 [15831717] J Neurosci Res. 2005 Jun 15;80(6):789-97 [15884015] Annu Rev Neurosci. 2005;28:223-50 [16022595] Clin Rev Allergy Immunol. 2005 Jun;28(3):249-56 [16129909] J Neurosci. 2005 Nov 23;25(47):10815-21 [16306394] Bioinformatics. 2006 May 1;22(9):1111-21 [16522673] J Neurosci. 2000 Apr 15;20(8):2896-903 [10751442] Oncogene. 2000 May 15;19(21):2468-73 [10851045] Oncogene. 2000 May 15;19(21):2548-56 [10851053] Cytokine. 2000 May;12(5):423-31 [10857755] J Neuroimmunol. 2001 Jul 2;117(1-2):87-96 [11431008] J Neurosci. 2002 Jan 15;22(2):486-92 [11784794] J Neurosci. 2002 Mar 1;22(5):1784-93 [11880507] Exp Neurol. 2002 May;175(1):1-9 [12009755] Toxicol Appl Pharmacol. 2002 May 1;180(3):205-18 [12009860] Neuroscientist. 2002 Jun;8(3):268-75 [12061506] Ann Neurol. 2002 Aug;52(2):135-43 [12210782] Exp Neurol. 2002 Sep;177(1):1-8 [12429205] Curr Top Microbiol Immunol. 2002;270:47-61 [12467243] Sci STKE. 2003 Feb 25;2003(171):re3 [12606705] Neurotoxicology. 2003 Jun;24(3):343-56 [12782100] Trends Neurosci. 2006 Sep;29(9):506-10 [16859761] Neuropsychopharmacology. 2006 Dec;31(12):2619-26 [16823390] Pharmacol Biochem Behav. 2007 Feb;86(2):327-33 [17169417] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbi.2010.09.003 ER - TY - JOUR T1 - Caloric excess or restriction mediated modulation of metabolic enzyme acetylation-proposed effects on cardiac growth and function. AN - 870546997; 21295620 AB - Caloric excess has been postulated to disrupt cardiac function via (i) the generation of toxic intermediates, (ii) via protein glycosylation and (iii) through the generation of reactive oxygen species. It is now increasingly being recognized that the nutrient intermediates themselves may modulate metabolic pathways through the post-translational modifications of metabolic enzymes. In light of the high energy demand of the heart, these nutrient mediated modulations in metabolic pathway functioning may play an important role in cardiac function and in the capacity of the heart to adapt to biomechanical stressors. In this review the role of protein acetylation and deacetylation in the control of metabolic programs is explored. Although not extensively investigated directly in the heart, the emerging data support that these nutrient mediated post-translational regulatory events (i) modulate cardiac metabolic pathways, (ii) integrate nutrient flux mediated post-translational effects with cardiac function and (iii) may be important in the development of cardiac pathology. Areas of investigation that need to be explored are highlighted. This article is part of a Special Issue entitled: Mitochondria and Cardioprotection. Published by Elsevier B.V. JF - Biochimica et biophysica acta AU - Sack, Michael N AD - Translational Medicine Branch, NHLBI, NIH, Bld 10-CRC, Room 5–3150, 10 Center Drive, Bethesda, MD, 20892-1454, USA. sackm@nhlbi.nih.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 1279 EP - 1285 VL - 1813 IS - 7 SN - 0006-3002, 0006-3002 KW - NAD KW - 0U46U6E8UK KW - AMP-Activated Protein Kinases KW - EC 2.7.11.1 KW - Sirtuins KW - EC 3.5.1.- KW - Index Medicus KW - NAD -- metabolism KW - Animals KW - Acetylation KW - Sirtuins -- metabolism KW - Circadian Rhythm KW - Metabolic Networks and Pathways KW - AMP-Activated Protein Kinases -- metabolism KW - Humans KW - Mitochondria, Heart -- metabolism KW - Heart -- physiology KW - Energy Intake KW - Caloric Restriction KW - Energy Metabolism KW - Myocardium -- metabolism KW - Heart -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/870546997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Caloric+excess+or+restriction+mediated+modulation+of+metabolic+enzyme+acetylation-proposed+effects+on+cardiac+growth+and+function.&rft.au=Sack%2C+Michael+N&rft.aulast=Sack&rft.aufirst=Michael&rft.date=2011-07-01&rft.volume=1813&rft.issue=7&rft.spage=1279&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbamcr.2011.01.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-05 N1 - Date created - 2011-06-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2007 Dec;27(24):8807-14 [17923681] Diabetes. 2007 Dec;56(12):2849-53 [17717279] Biochem Biophys Res Commun. 2008 Feb 1;366(1):174-9 [18054327] Cell. 2008 Jan 25;132(2):171-6 [18243090] 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http://dx.doi.org/10.1016/j.bbamcr.2011.01.032 ER - TY - JOUR T1 - Tight Regulation of Transgene Expression by Mifepristone-Inducible System after In Vitro Delivery by Lentiviral Vectors to Neural Progenitor Cells AN - 1673391504; PQ0001372559 AB - The ability to regulate expression of target genes in progenitor cells will be an important tool for their study and application towards gene and cell therapy. We have developed a mifepristone (MFP) inducible system for regulated expression of target genes in neural progenitor cells (NPCs). As MFP readily penetrates the blood-brain barrier, this system is particularly amendable for use in the CNS. Initial analysis will look at NPCs inducibly expressing fluorescent markers and/or luciferase. Rodents will be treated with placebo or MFP for set periods of time and expression of target transgenes will be evaluated by fluorescent microscopy, immunohistochemistry, or bioluminescence. JF - Molecular Therapy AU - Grunseich, Christopher AU - Shi, Yijun AU - Fischbeck, Kenneth H AU - Pierson, Tyler M AD - Neurogenetics Branch/NINDS, National Institutes of Health, Bethesda, MD, USA Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 1369 EP - 1370 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 19 IS - 7 SN - 1525-0016, 1525-0016 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Expression vectors KW - Central nervous system KW - mifepristone KW - Blood-brain barrier KW - Bioluminescence KW - Transgenes KW - Microscopy KW - Fluorescent indicators KW - Neural stem cells KW - Immunohistochemistry KW - W 30905:Medical Applications KW - G 07730:Development & Cell Cycle KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673391504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=Tight+Regulation+of+Transgene+Expression+by+Mifepristone-Inducible+System+after+In+Vitro+Delivery+by+Lentiviral+Vectors+to+Neural+Progenitor+Cells&rft.au=Grunseich%2C+Christopher%3BShi%2C+Yijun%3BFischbeck%2C+Kenneth+H%3BPierson%2C+Tyler+M&rft.aulast=Grunseich&rft.aufirst=Christopher&rft.date=2011-07-01&rft.volume=19&rft.issue=7&rft.spage=1369&rft.isbn=&rft.btitle=&rft.title=Molecular+Therapy&rft.issn=15250016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Expression vectors; Central nervous system; mifepristone; Bioluminescence; Blood-brain barrier; Microscopy; Transgenes; Fluorescent indicators; Immunohistochemistry; Neural stem cells ER - TY - JOUR T1 - Human Papillomavirus Pseudoviruses as Gene Delivery Vectors for Murine and Human Tumors AN - 1673383520; PQ0001372552 AB - Human papillomavirus pseudoviruses (HPV PsV) comprising HPV L1 and L2 proteins are promising vector candidates due to their potential safety and ability to deliver tailor-made plasmid genomes in the absence of any viral genes. We report here that HPV PsV have a remarkable tropism for murine and human tumor lines and tumors in vivo. The PsV infected most cell lines in the NCI60 human cancer panel as well as several mouse epithelial tumor lines in vitro. The ability to infect many cancer-derived lines while ignoring normal tissues suggested that HPV PsV could be effective gene delivery vectors for tumor therapy. Based on these findings, we hypothesized that HPV PsV could specifically infect mouse and human models of ovarian cancer and facilitate tumor cell death by delivering therapeutic genes. Together, our results suggest that HPV pseudoviruses are promising vectors for specific cytotoxic tumor therapy with a high therapeutic index. JF - Molecular Therapy AU - Cerio, Rebecca J AU - Roberts, Jeffrey N AU - Thompson, Cynthia D AU - Lowy, Douglas R AU - Schiller, John T AD - Laboratory of Cellular Oncology, National Cancer Institute, NIH, Bethesda, MD, USA Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 1365 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 19 IS - 7 SN - 1525-0016, 1525-0016 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Ovarian cancer KW - Cytotoxicity KW - Gene transfer KW - Tropism KW - Animal models KW - Tumors KW - Plasmids KW - Tumor cells KW - Human papillomavirus KW - W 30905:Medical Applications KW - G 07760:Viruses & Phages KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673383520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=Human+Papillomavirus+Pseudoviruses+as+Gene+Delivery+Vectors+for+Murine+and+Human+Tumors&rft.au=Cerio%2C+Rebecca+J%3BRoberts%2C+Jeffrey+N%3BThompson%2C+Cynthia+D%3BLowy%2C+Douglas+R%3BSchiller%2C+John+T&rft.aulast=Cerio&rft.aufirst=Rebecca&rft.date=2011-07-01&rft.volume=19&rft.issue=7&rft.spage=1365&rft.isbn=&rft.btitle=&rft.title=Molecular+Therapy&rft.issn=15250016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Genomes; Ovarian cancer; Cytotoxicity; Gene transfer; Tropism; Animal models; Tumors; Plasmids; Tumor cells; Human papillomavirus ER - TY - JOUR T1 - Comparison of Phylogenetic Trees and Search for a Central Trend in the "Forest of Life" AN - 1627976174; 20907713 AB - The widespread exchange of genes among prokaryotes, known as horizontal gene transfer (HGT), is often considered to "uproot" the Tree of Life (TOL). Indeed, it is by now fully clear that genes in general possess different evolutionary histories. However, the possibility remains that the TOL concept can be reformulated and remain valid as a statistical central trend in the phylogenetic "Forest of Life" (FOL). This article describes a computational pipeline developed to chart the FOL by comparative analysis of thousands of phylogenetic trees. This analysis reveals a distinct, consistent phylogenetic signal that is particularly strong among the Nearly Universal Trees (NUTs), which correspond to genes represented in all or most of the analyzed organisms. Despite the substantial amount of apparent HGT seen even among the NUTs, these gene transfers appear to be distributed randomly and do not obscure the central tree-like trend. JF - Journal of Computational Biology AU - Koonin, Eugene V AU - PUIGBO, PERE AU - Wolf, Yuri I AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 917 EP - 924 PB - Mary Ann Liebert, Inc., 2 Madison Ave Larchmont NY 10538 United States VL - 18 IS - 7 SN - 1557-8666, 1557-8666 KW - Biotechnology and Bioengineering Abstracts KW - evolution KW - genomics KW - Phylogeny KW - Statistics KW - Forests KW - Nuts KW - Prokaryotes KW - Computer applications KW - Evolution KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627976174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Computational+Biology&rft.atitle=Comparison+of+Phylogenetic+Trees+and+Search+for+a+Central+Trend+in+the+%22Forest+of+Life%22&rft.au=Koonin%2C+Eugene+V%3BPUIGBO%2C+PERE%3BWolf%2C+Yuri+I&rft.aulast=Koonin&rft.aufirst=Eugene&rft.date=2011-07-01&rft.volume=18&rft.issue=7&rft.spage=917&rft.isbn=&rft.btitle=&rft.title=Journal+of+Computational+Biology&rft.issn=15578666&rft_id=info:doi/10.1089%2Fcmb.2010.0185 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Phylogeny; Statistics; Nuts; Forests; Prokaryotes; Computer applications; Evolution DO - http://dx.doi.org/10.1089/cmb.2010.0185 ER - TY - JOUR T1 - Organic arsenic in the soil environment; speciation, occurrence, transformation, and adsorption behavior AN - 1535204130; 2014-039576 AB - An attempt is made to describe the fate and behavior of organic arsenic (As) compounds in the soil environment, based on an extensive literature researches. The objective of this review is to provide an overview on the state of knowledge to date about the occurrence and potential transformation of organic As, including methylation, degradation, and hydration, in soils and their uptake and accumulation in plants and animals. Accordingly, the biogeochemical cycle of organic As in the soil environment is proposed. Copyright 2010 Springer Science+Business Media B.V. JF - Water, Air and Soil Pollution AU - Huang, Jen-How AU - Hu, Kan-Nian AU - Decker, Berryinne Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 401 EP - 415 PB - Springer, Dordrecht VL - 219 IS - 1-4 SN - 0049-6979, 0049-6979 KW - methylation KW - peatlands KW - topsoil KW - degradation KW - arsenates KW - transport KW - agrochemicals KW - depositional environment KW - kinetics KW - soils KW - pollutants KW - herbicides KW - arsenic KW - pollution KW - adsorption KW - geochemical cycle KW - organic compounds KW - mires KW - arsenites KW - atmospheric transport KW - metals KW - transformations KW - pesticides KW - leaching KW - chemical fractionation KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1535204130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water%2C+Air+and+Soil+Pollution&rft.atitle=Organic+arsenic+in+the+soil+environment%3B+speciation%2C+occurrence%2C+transformation%2C+and+adsorption+behavior&rft.au=Huang%2C+Jen-How%3BHu%2C+Kan-Nian%3BDecker%2C+Berryinne&rft.aulast=Huang&rft.aufirst=Jen-How&rft.date=2011-07-01&rft.volume=219&rft.issue=1-4&rft.spage=401&rft.isbn=&rft.btitle=&rft.title=Water%2C+Air+and+Soil+Pollution&rft.issn=00496979&rft_id=info:doi/10.1007%2Fs11270-010-0716-2 L2 - http://www.springerlink.com/(hi4cjunvnzs4hnradzi0ib55)/app/home/journal.asp?referrer=parent&backto=linkingpublicationresults,1:100344,1 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. Reference includes data supplied by Springer Verlag, Berlin, Federal Republic of Germany N1 - Date revised - 2014-01-01 N1 - Number of references - 72 N1 - Document feature - illus. N1 - SuppNotes - Includes appendices N1 - Last updated - 2014-06-13 N1 - CODEN - WAPLAC N1 - SubjectsTermNotLitGenreText - adsorption; agrochemicals; arsenates; arsenic; arsenites; atmospheric transport; chemical fractionation; degradation; depositional environment; geochemical cycle; herbicides; kinetics; leaching; metals; methylation; mires; organic compounds; peatlands; pesticides; pollutants; pollution; soils; topsoil; transformations; transport DO - http://dx.doi.org/10.1007/s11270-010-0716-2 ER - TY - JOUR T1 - The 1918 influenza pandemic in Florianopolis: A subtropical city in Brazil AN - 1520387899; 19655577 AB - Few studies have addressed the impact and dynamics of the 1918-1919 influenza pandemic in tropical and sub-tropical areas. To help cover this gap, we analyzed all death certificates issued from October 1913 to June 1921 in Florianopolis (Brazil), a subtropical state capital with a population of 41,298 inhabitants in 1920. In November and December 1918 (spring) there were a total of 70 and 14 deaths due to influenza and pneumonia, respectively, in contrast to a mean annual mortality attributed to these causes of 8.1 deaths, usually concentrated between January and August (summer to winter). We also determined the mortality burden due to the pandemic through the analysis of excess mortality during the pandemic period against the baseline mortality in the same months from other years. We obtained a total of 127 deaths (0.33% of the total population), nearly twice the number of deaths documented by death certificates from this period. No other influenza pandemic waves were detected in earlier or subsequent months. Our results confirm the observed patterns of age-shift in mortality in pandemic scenarios, with young adults as the most affected age-group. The pandemic in Florianopolis was further characterized by some specific outcomes: (1) there was a discrete peak in mortality due to renal causes in the initial phase of the pandemic; (2) pandemic influenza did not affect the number of reported bronchitis and bronchiolitis deaths (unusually high in the year preceding the pandemic); and (3) the mortality burden was proportionally lower in Florianopolis than in large urban centers such as Sao Paulo and Rio de Janeiro. We suggest that this latter outcome was the result of an effective and prompt network of voluntary solidarity assistance (as endorsed by contemporaneous documents), which was probably more difficult to implement in larger metropolis. JF - Vaccine AU - Alonso, Wladimir J AU - Nascimento, Francielle C AU - Acuna-Soto, Rodolfo AU - Schuck-Paim, Cynthia AU - Miller, Mark A AD - Fogarty International Center, National Institutes of Health, Bethesda, MD, USA Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - B16 EP - B20 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 29 SN - 0264-410X, 0264-410X KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Mortality KW - Summer KW - Winter KW - Brazil, Sao Paulo KW - Renal KW - Influenza KW - Brazil, Rio de Janeiro KW - pandemics KW - Brazil KW - Brazil, Santa Catarina, Santa Catarina I., Florianopolis KW - Kidney KW - Waves KW - Bronchitis KW - Vaccines KW - Young adults KW - Bronchopneumonia KW - Pneumonia KW - Urban areas KW - Urban environments KW - F 06905:Vaccines KW - H 4000:Food and Drugs KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520387899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=The+1918+influenza+pandemic+in+Florianopolis%3A+A+subtropical+city+in+Brazil&rft.au=Alonso%2C+Wladimir+J%3BNascimento%2C+Francielle+C%3BAcuna-Soto%2C+Rodolfo%3BSchuck-Paim%2C+Cynthia%3BMiller%2C+Mark+A&rft.aulast=Alonso&rft.aufirst=Wladimir&rft.date=2011-07-01&rft.volume=29&rft.issue=&rft.spage=B16&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2011.02.047 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Last updated - 2014-07-24 N1 - SubjectsTermNotLitGenreText - Influenza; Mortality; pandemics; Kidney; Bronchitis; Waves; Pneumonia; Bronchopneumonia; Urban environments; Renal; Summer; Young adults; Vaccines; Winter; Urban areas; Brazil, Sao Paulo; Brazil, Rio de Janeiro; Brazil, Santa Catarina, Santa Catarina I., Florianopolis; Brazil DO - http://dx.doi.org/10.1016/j.vaccine.2011.02.047 ER - TY - JOUR T1 - Radiotherapy and Immediate Expander/Implant Breast Reconstruction: Should Reconstruction be Delayed? AN - 1399902533; 15453201 AB - Abstract: Chest wall irradiation is very common for mastectomy patients that have opted for immediate breast reconstruction. We reviewed a 6year experience with tissue expander implant reconstruction with and without radiotherapy in 97 patients. All patients were evaluated with respect to aesthetic outcome, infection, implant exposure, capsular contracture, displacement and failure of the reconstruction; more than 50% of our irradiated patients resulted in a complication. The findings of this study demonstrate that the rate of complications and the rate of patients requiring corrective surgeries in irradiated patients is significant in early follow up. JF - Breast Journal AU - Drucker-Zertuche, Monica AU - Bargallo-Rocha, Enrique AU - Zamora-Del, Rio Raul AD - Division of Plastic and Reconstructive Surgery, National Cancer Institute of Mexico City, Mexico City, Mexico Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 365 EP - 370 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 17 IS - 4 SN - 1075-122X, 1075-122X KW - Biotechnology and Bioengineering Abstracts KW - Radiation KW - Surgery KW - Radiotherapy KW - Infection KW - Chest KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1399902533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+Journal&rft.atitle=Radiotherapy+and+Immediate+Expander%2FImplant+Breast+Reconstruction%3A+Should+Reconstruction+be+Delayed%3F&rft.au=Drucker-Zertuche%2C+Monica%3BBargallo-Rocha%2C+Enrique%3BZamora-Del%2C+Rio+Raul&rft.aulast=Drucker-Zertuche&rft.aufirst=Monica&rft.date=2011-07-01&rft.volume=17&rft.issue=4&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=Breast+Journal&rft.issn=1075122X&rft_id=info:doi/10.1111%2Fj.1524-4741.2011.01090.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-07-01 N1 - Document feature - figure 2 N1 - Last updated - 2013-08-12 N1 - SubjectsTermNotLitGenreText - Radiation; Surgery; Radiotherapy; Chest; Infection DO - http://dx.doi.org/10.1111/j.1524-4741.2011.01090.x ER - TY - JOUR T1 - Realizing the promise of Web 2.0: engaging community intelligence AN - 1272075404; 4386019 AB - Discussions of Health 2.0 , a term first coined in 2005, were guided by three main tenets: (a) health was to involve more participation, because an evolution in the web encouraged more direct consumer engagement in their own health care; (b) data was to become the new Intel Inside for systems supporting the vital decisions in health; and (c) a sense of collective intelligence from the network would supplement traditional sources of knowledge in health decision making. Interests in understanding the implications of a new paradigm for patient engagement in health and health care were kindled by findings from surveys such as the National Cancer Institute's Health Information National Trends Survey, showing that patients were quick to look online for information to help them cope with disease. This article considers how these 3 facets of Health 2.0-participation, data, and collective intelligence-can be harnessed to improve the health of the nation according to Healthy People 2020 goals. The authors begin with an examination of evidence from behavioral science to understand how Web 2.0 participative technologies may influence patient processes and outcomes, for better or worse, in an era of changing communication technologies. The article then focuses specifically on the clinical implications of Health 2.0 and offers recommendations to ensure that changes in the communication environment do not detract from national (e.g., Healthy People 2020) health goals. Changes in the clinical environment, as catalyzed by the Health Information Technology for Economic and Clinical Health Act to take advantage of Health 2.0 principles in evidence-based ways, are also considered. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Hesse, Bradford W AU - O'Connell, Mary AU - Augustson, Erik M AU - Chou, Wen-ying Sylvia AU - Shaikh, Abdul R AU - Finney Rutten, Lila J AD - National Institutes of Health ; SAIC-Frederick, Inc. Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 10 EP - 31 VL - 16 IS - Supp. 1 SN - 1081-0730, 1081-0730 KW - Sociology KW - Web 2.0 KW - Decision making KW - Intelligence KW - Social networks KW - Health KW - Patients KW - Engagement KW - Community participation KW - Information and communication technologies KW - Internet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1272075404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Realizing+the+promise+of+Web+2.0%3A+engaging+community+intelligence&rft.au=Hesse%2C+Bradford+W%3BO%27Connell%2C+Mary%3BAugustson%2C+Erik+M%3BChou%2C+Wen-ying+Sylvia%3BShaikh%2C+Abdul+R%3BFinney+Rutten%2C+Lila+J&rft.aulast=Hesse&rft.aufirst=Bradford&rft.date=2011-07-01&rft.volume=16&rft.issue=Supp.+1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 6813 6518; 6518; 9271 7890 5792 10484; 5772; 6608 6085; 11873 8634; 2614 11880 11878 9003; 4278; 3322 6071 1542 11325 ER - TY - JOUR T1 - Improved partition efficiency with threaded cylindrical column in vortex counter-current chromatography AN - 1266749630; 14964798 AB - Type-I coil planet centrifuge produces a uniformly circulating centrifugal force field to produce vortex motion of two immiscible solvent phases in a cylindrical cavity of the separation column to perform efficient countercurrent chromatography. The partition efficiency obtained from the original vortex column was substantially improved by threading the cylindrical cavity to increase the area of mass transfer between the two phases. Partition efficiency of the threaded column was evaluated by three different two-phase solvent systems with a broad range of hydrophobicity each with a set of suitable test samples. Overall results of the present studies indicated that the threaded cylindrical column substantially improves the partition efficiency in terms of theoretical plate number, peak resolution, and height equivalent of one theoretical plate. The results also indicated that higher peak resolution is produced by eluting either the upper phase in the head to tail direction or the lower phase in the reversed direction. When there is a choice in the mobile phase, a better separation is achieved by using the less viscous phase as the mobile phase. Since the present system gives extremely low column pressure, it may be a potential alternative to the conventional type-J HSCCC system for a large-scale preparative separation. JF - Journal of Chromatography A AU - Ito, Yoichiro AU - Ma, Zhiyong AU - Clary, Robert AU - Powell, Jimmie AU - Knight, Martha AU - Finn, Thomas M AD - Bioseparation Technology Laboratory, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA, itoy2@mail.nih.gov Y1 - 2011/07/01/ PY - 2011 DA - 2011 Jul 01 SP - 4065 EP - 4070 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1218 IS - 26 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - Vortex counter-current chromatography KW - Type-I coil planet centrifuge KW - Cylindrical vortex column KW - Threaded cylindrical vortex column KW - Testing Procedures KW - Chromatography KW - Chromatographic techniques KW - Mass Transfer KW - Solvents KW - Countercurrents KW - Centrifugal force KW - Analytical Methods KW - Centrifuges KW - Mass transfer KW - SW 5010:Network design KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266749630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Improved+partition+efficiency+with+threaded+cylindrical+column+in+vortex+counter-current+chromatography&rft.au=Ito%2C+Yoichiro%3BMa%2C+Zhiyong%3BClary%2C+Robert%3BPowell%2C+Jimmie%3BKnight%2C+Martha%3BFinn%2C+Thomas+M&rft.aulast=Ito&rft.aufirst=Yoichiro&rft.date=2011-07-01&rft.volume=1218&rft.issue=26&rft.spage=4065&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2011.04.081 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Centrifugal force; Centrifuges; Chromatographic techniques; Solvents; Mass transfer; Countercurrents; Testing Procedures; Chromatography; Analytical Methods; Mass Transfer DO - http://dx.doi.org/10.1016/j.chroma.2011.04.081 ER - TY - JOUR T1 - Psychosocial aspects of migratory quarry workers AN - 1082143846; 4343968 AB - Quarry workers form a major part of the work force of the unorganised industrial sector. Various psychosocial stressors makes quarry workers vulnerable to various psychological disorders. The current study focuses on psychological distress, disability levels and the quality of community life existing among quarry workers. The results show that there is a significant positive correlation between psychological distress and disability. The community of quarry workers live in pathetic conditions. Statistics reveal that 97.6% have no sanitation, toilet or drainage facilities. The implications of the results are discussed and the need for professional guidance from psychiatric social workers. Adapted from the source document. Reprinted with the permission of the TATA Institute of Social Sciences, India JF - Indian journal of social work AU - Raj, E Aravind AU - Sekar, K AU - Johnson, J AD - National Institute of Mental Health and Neurosciences, Bangalore Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 351 EP - 364 VL - 72 IS - 3 SN - 0019-5634, 0019-5634 KW - Sociology KW - Workers KW - Sanitation KW - Mental stress KW - Labour force KW - Social workers KW - Industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1082143846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+journal+of+social+work&rft.atitle=Psychosocial+aspects+of+migratory+quarry+workers&rft.au=Raj%2C+E+Aravind%3BSekar%2C+K%3BJohnson%2C+J&rft.aulast=Raj&rft.aufirst=E&rft.date=2011-07-01&rft.volume=72&rft.issue=3&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Indian+journal+of+social+work&rft.issn=00195634&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 13682; 6431; 7953 7954; 11260 13463 7625; 11952 11949 13521; 7143 6074 1952 ER - TY - JOUR T1 - Burden, Characteristics, and Outcome of Injury among Females: Observations from Bengaluru, India AN - 1038111039; 201222794 AB - Purpose: With injuries becoming a leading cause of mortality, morbidity, disability, and socioeconomic losses in India and other low- and middle-income countries, its impact on the female population is significant, affecting their multiple roles and functions. The objectives of the present study were to identify the burden, causes, characteristics, and outcomes of injury among females in Bengaluru city. Methods: Information on fatal and nonfatal injuries was collected from the Bangalore city police and the emergency rooms of 22 partner hospitals, respectively, under the Bengaluru Injury Surveillance Program in 2007 and 2008. Data were collected in an uniform manner by trained personnel using standardized methods. Findings: Females across all age groups accounted for 26% of fatal and 23% of nonfatal injuries and the highest numbers were among those 16 to 45 years old. Burns and hanging were the leading causes of death; road crashes and poisonings were the major causes of nonfatal injuries. Nearly half of the fatal and one third of the nonfatal injuries were suicides. Pedestrians and two-wheeler riders/pillions were mainly involved in road crashes. Very few received first aid at the injury site and the commonest modes of transportation were a private vehicle or taxi and the local three-wheeler vehicle. More than half of the injured were admitted in the hospitals for medical or surgical management. Conclusion: Injuries are a major, preventable public health problem. There is a need to strengthen injury prevention and control programs, as well as increased research to understand risk factors and injury mechanisms. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Kavita, Rajesh AU - Girish, Nagarajarao AU - Gururaj, Gopalkrishna AD - Department of Epidemiology, WHO Collaborating Centre for Injury Prevention and Safety Promotion, National Institute of Mental Health and Neurosciences, Bangalore-560029, India Phone: +91-80-26995244/45, Fax: +91-80-26562121 Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 320 EP - 326 PB - Elsevier Science, New York NY VL - 21 IS - 4 SN - 1049-3867, 1049-3867 KW - Injuries KW - Vehicles KW - Burden KW - Morbidity-Mortality KW - Hospitals KW - India KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038111039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=Burden%2C+Characteristics%2C+and+Outcome+of+Injury+among+Females%3A+Observations+from+Bengaluru%2C+India&rft.au=Kavita%2C+Rajesh%3BGirish%2C+Nagarajarao%3BGururaj%2C+Gopalkrishna&rft.aulast=Kavita&rft.aufirst=Rajesh&rft.date=2011-07-01&rft.volume=21&rft.issue=4&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2010.12.003 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Injuries; India; Hospitals; Morbidity-Mortality; Vehicles; Burden DO - http://dx.doi.org/10.1016/j.whi.2010.12.003 ER - TY - JOUR T1 - The Traditional Medicine Spilanthes acmella, and the Alkylamides Spilanthol and Undeca-2E-ene-8,10-diynoic Acid Isobutylamide, Demonstrate In Vitro and In Vivo Antimalarial Activity AN - 1028027150; 16702071 AB - Keywords: Plasmodium falciparum; alkylamides; deca-2E,6Z,8E-trienoic acid isobutylamide; malaria; traditional medicine; phytotherapy Spilanthes spp. are used as traditional herbal medicines in Africa and India to treat malaria. Yet, to date, there are no data on the active constituents or the most effective extraction methods for this indication. The isolated alkylamides, spilanthol and undeca-2E-ene-8,10-diynoic acid isobutylamide, found in S. acmella Murr., were shown to have IC50s of 16.5 Delta *mg/mL and 41.4 Delta *mg/mL on Plasmodium falciparum strain PFB and IC50s of 5.8 Delta *mg/mL and 16.3 Delta *mg/mL for the chloroquine resistant P. falciparum K1 strain, respectively. Further investigations revealed that at relatively low concentrations, spilanthol and the water extract of S. acmella reduced the parasitemia 59% and 53% in mice infected with P. yoelii yoelii 17XNL at 5mg/kg and 50mg/kg, respectively. Unexpectedly, the 95% ethanol extract of S. acmella was less effective (36% reduction in parasitemia) at 50mg/kg. These results provide the first evidence supporting S. acmella against malaria and demonstrating active constituents in S. acmella against P. falciparum. JF - Phytotherapy Research AU - Anonymous AD - National Institute on Aging, National Institutes of Health, Laboratory of Clinical Investigation, Baltimore, MD, USA, phytochemks@gmail.com Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 1098 EP - 1101 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 25 IS - 7 SN - 1099-1573, 1099-1573 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Phytotherapy KW - Parasites KW - Human diseases KW - Data processing KW - Spilanthes KW - Acmella KW - Chloroquine KW - Malaria KW - Plasmodium falciparum KW - India KW - Public health KW - parasitemia KW - Herbal medicines KW - Africa KW - Antimalarial activity KW - Medicine KW - Ethanol KW - K 03410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028027150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Phytotherapy+Research&rft.atitle=The+Traditional+Medicine+Spilanthes+acmella%2C+and+the+Alkylamides+Spilanthol+and+Undeca-2E-ene-8%2C10-diynoic+Acid+Isobutylamide%2C+Demonstrate+In+Vitro+and+In+Vivo+Antimalarial+Activity&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-07-01&rft.volume=25&rft.issue=7&rft.spage=1098&rft.isbn=&rft.btitle=&rft.title=Phytotherapy+Research&rft.issn=10991573&rft_id=info:doi/10.1002%2Fptr.3395 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ptr.3395/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Medicine; Malaria; Public health; Phytotherapy; parasitemia; Data processing; Herbal medicines; Chloroquine; Antimalarial activity; Ethanol; Spilanthes; Acmella; Plasmodium falciparum; Africa; India DO - http://dx.doi.org/10.1002/ptr.3395 ER - TY - JOUR T1 - Advancing the health of our aging population: A lead role for nursing science AN - 1023094160; 201214740 AB - Discussion includes coverage of the racial/ethnic diversity of older adults; caregiver burden; interdisciplinary collaboration and research translation; prevention and wellness across the life span; the next generation of nurses and nurse scientists. [Copyright Elsevier B.V.] JF - Nursing Outlook AU - Grady, Patricia A AD - National Institute of Nursing Research info@ninr.nih.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 207 EP - 209 PB - Elsevier Ltd, The Netherlands VL - 59 IS - 4 SN - 0029-6554, 0029-6554 KW - Translation KW - Nursing KW - Interdisciplinary approach KW - Life span KW - Nurses KW - Caretaker syndrome KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023094160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing+Outlook&rft.atitle=Advancing+the+health+of+our+aging+population%3A+A+lead+role+for+nursing+science&rft.au=Grady%2C+Patricia+A&rft.aulast=Grady&rft.aufirst=Patricia&rft.date=2011-07-01&rft.volume=59&rft.issue=4&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Nursing+Outlook&rft.issn=00296554&rft_id=info:doi/10.1016%2Fj.outlook.2011.05.017 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nurses; Interdisciplinary approach; Translation; Life span; Nursing; Caretaker syndrome DO - http://dx.doi.org/10.1016/j.outlook.2011.05.017 ER - TY - JOUR T1 - 9,400 yr B.P.; the mortality of mollusk shell (Mya truncata) at high Arctic is associated with a sudden cooling event AN - 1020540111; 2012-058162 AB - An 118-cm-long, well-preserved sediment profile was collected from a paleo-notch formed by ocean wave action before rising to the terrace on Ny-Alesund, Svalbard, Norway. A large number of mollusk shell fragments, predominantly Mya truncata, were found in the sediment profile. AMS (super 14) C dating and stable oxygen and carbon isotope analyses were performed on the shell fragments samples. The reservoir-corrected radiocarbon ages averaged approximately 9,400 yr B.P., which accurately dates the raised terrace and the upper marine limit after Kongsfjorden was completely deglaciated. The calibrated aragonite isotopic temperature equation was established for Ny-Alesund by comparing the delta (super 18) O profiles of modern mollusks as follows: T( degrees C)=16.26-3.68(delta (super 18) O (sub aragonite-PDB) -delta (super 18) O (sub water-VSMOW) ). The reconstructed paleotemperature range was -0.52 to +4.78 degrees C, warmer than today by about 1 degrees C, which was further confirmed by reconstructed sea surface temperature (SST) in west Svalbard. Moreover, the mortality of mollusks was very likely caused by an abrupt cooling event at about 9,400 yr B.P., which was triggered by reduced insolation, weakened thermohaline circulation, and abruptly decreased SST. More evidences for this distinct but short cooling event centered at about 9,400 yr B.P. were found in Northern Siberia, North Atlantic, Alps, and Eastern Europe. Copyright 2010 Springer-Verlag JF - Environmental Earth Sciences AU - Yuan, Linxi AU - Sun, Liguang AU - Wei, Gangjian AU - Long, Nanye AU - Xie, Zhouqing AU - Wang, Yuhong Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 1385 EP - 1393 PB - Springer, Berlin VL - 63 IS - 6 SN - 1866-6280, 1866-6280 KW - Spitsbergen Island KW - oxygen KW - lower Holocene KW - Svalbard KW - isotopes KW - Spitsbergen KW - paleoclimatology KW - Holocene KW - stable isotopes KW - Cenozoic KW - Ny-Alesund KW - paleotemperature KW - carbon KW - arctic environment KW - Mya truncata KW - sediments KW - Invertebrata KW - ecology KW - Mollusca KW - shells KW - Quaternary KW - isotope ratios KW - Arctic region KW - C-13/C-12 KW - O-18/O-16 KW - habitat KW - thermohaline circulation KW - sea-surface temperature KW - fossil record KW - 24:Quaternary geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020540111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Earth+Sciences&rft.atitle=9%2C400+yr+B.P.%3B+the+mortality+of+mollusk+shell+%28Mya+truncata%29+at+high+Arctic+is+associated+with+a+sudden+cooling+event&rft.au=Yuan%2C+Linxi%3BSun%2C+Liguang%3BWei%2C+Gangjian%3BLong%2C+Nanye%3BXie%2C+Zhouqing%3BWang%2C+Yuhong&rft.aulast=Yuan&rft.aufirst=Linxi&rft.date=2011-07-01&rft.volume=63&rft.issue=6&rft.spage=1385&rft.isbn=&rft.btitle=&rft.title=Environmental+Earth+Sciences&rft.issn=18666280&rft_id=info:doi/10.1007%2Fs12665-010-0808-8 L2 - http://www.springerlink.com/content/1866-6280 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by Springer Verlag, Berlin, Federal Republic of Germany N1 - Date revised - 2012-01-01 N1 - Number of references - 58 N1 - Document feature - illus. incl. 3 tables, sketch map N1 - Last updated - 2012-06-15 N1 - SubjectsTermNotLitGenreText - arctic environment; Arctic region; C-13/C-12; carbon; Cenozoic; ecology; fossil record; habitat; Holocene; Invertebrata; isotope ratios; isotopes; lower Holocene; Mollusca; Mya truncata; Ny-Alesund; O-18/O-16; oxygen; paleoclimatology; paleotemperature; Quaternary; sea-surface temperature; sediments; shells; Spitsbergen; Spitsbergen Island; stable isotopes; Svalbard; thermohaline circulation DO - http://dx.doi.org/10.1007/s12665-010-0808-8 ER - TY - JOUR T1 - The Case of E-Book Management: A Multiple Access Points Approach Report from the 2011 Medical Library Association Annual Meeting May 13-18, 2011, Minneapolis, Minnesota AN - 1018334101; 201205665 AB - At the Medical Library Association's 2011 Annual Meeting, Jie Li discussed the Baugh Biomedical Library's challenges with ebook management and creating useful patron access points. For this study, the library compared usage of e-book databases containing the top core clinical titles, as identified by a 2010 Association of Academic Health Sciences Libraries survey. Adapted from the source document. JF - Journal of Electronic Resources Librarianship AU - Mihlrad, Leigh AD - National Institutes of Health Library Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 303 EP - 304 PB - Haworth Press/Taylor & Francis, Philadelphia PA VL - 23 IS - 3 SN - 1941-126X, 1941-126X KW - Information retrieval KW - Electronic books KW - Medical libraries KW - Online data bases KW - article KW - 5.18: ELECTRONIC MEDIA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018334101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Electronic+Resources+Librarianship&rft.atitle=The+Case+of+E-Book+Management%3A+A+Multiple+Access+Points+Approach+Report+from+the+2011+Medical+Library+Association+Annual+Meeting+May+13-18%2C+2011%2C+Minneapolis%2C+Minnesota&rft.au=Mihlrad%2C+Leigh&rft.aulast=Mihlrad&rft.aufirst=Leigh&rft.date=2011-07-01&rft.volume=23&rft.issue=3&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Journal+of+Electronic+Resources+Librarianship&rft.issn=1941126X&rft_id=info:doi/10.1080%2F1941126X.2011.601248 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Medical libraries; Electronic books; Information retrieval; Online data bases DO - http://dx.doi.org/10.1080/1941126X.2011.601248 ER - TY - JOUR T1 - Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial AN - 1017971824; 16703801 AB - Objectives Women with a sonographic short cervix in the mid-trimester are at increased risk for preterm delivery. This study was undertaken to determine the efficacy and safety of using micronized vaginal progesterone gel to reduce the risk of preterm birth and associated neonatal complications in women with a sonographic short cervix. Methods This was a multicenter, randomized, double-blind, placebo-controlled trial that enrolled asymptomatic women with a singleton pregnancy and a sonographic short cervix (10-20 mm) at 19 + 0 to 23 + 6 weeks of gestation. Women were allocated randomly to receive vaginal progesterone gel or placebo daily starting from 20 to 23 + 6 weeks until 36 + 6 weeks, rupture of membranes or delivery, whichever occurred first. Randomization sequence was stratified by center and history of a previous preterm birth. The primary endpoint was preterm birth before 33 weeks of gestation. Analysis was by intention to treat. Results Of 465 women randomized, seven were lost to follow-up and 458 (vaginal progesterone gel, n = 235; placebo, n = 223) were included in the analysis. Women allocated to receive vaginal progesterone had a lower rate of preterm birth before 33 weeks than did those allocated to placebo (8.9% (n = 21) vs 16.1% (n = 36); relative risk (RR), 0.55; 95% CI, 0.33-0.92; P = 0.02). The effect remained significant after adjustment for covariables (adjusted RR, 0.52; 95% CI, 0.31-0.91; P = 0.02). Vaginal progesterone was also associated with a significant reduction in the rate of preterm birth before 28 weeks (5.1% vs 10.3%; RR, 0.50; 95% CI, 0.25-0.97; P = 0.04) and 35 weeks (14.5% vs 23.3%; RR, 0.62; 95% CI, 0.42-0.92; P = 0.02), respiratory distress syndrome (3.0% vs 7.6%; RR, 0.39; 95% CI, 0.17-0.92; P = 0.03), any neonatal morbidity or mortality event (7.7% vs 13.5%; RR, 0.57; 95% CI, 0.33-0.99; P = 0.04) and birth weight < 1500 g (6.4% (15/234) vs 13.6% (30/220); RR, 0.47; 95% CI, 0.26-0.85; P = 0.01). There were no differences in the incidence of treatment-related adverse events between the groups. Conclusions The administration of vaginal progesterone gel to women with a sonographic short cervix in the mid-trimester is associated with a 45% reduction in the rate of preterm birth before 33 weeks of gestation and with improved neonatal outcome. JF - Ultrasound in Obstetrics and Gynecology AU - Hassan, S S AU - Romero, R AU - Vidyadhari, D AU - Fusey, S AU - Baxter, J K AU - Khandelwal, M AU - Vijayaraghavan, J AU - Trivedi, Y AU - Soma-Pillay, P AU - Sambarey, P AU - Dayal, A AU - Potapov, V AU - O'Brien, J AU - Astakhov, V AU - Yuzko, O AU - Kinzler, W AU - Dattel, B AU - Sehdev, H AU - Mazheika, L AU - Manchulenko, D AU - Gervasi, M T AU - Sullivan, L AU - Conde-Agudelo, A AU - Phillips, J A AU - Creasy, G W AD - Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Bethesda, MD and Detroit, MI, USA Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 18 EP - 31 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 38 IS - 1 SN - 1469-0705, 1469-0705 KW - Biotechnology and Bioengineering Abstracts KW - Birth KW - Birth weight KW - Cervix KW - Gestation KW - Gynecology KW - Morbidity KW - Mortality KW - Motivation KW - Neonates KW - Obstetrics KW - Pregnancy KW - Progesterone KW - Respiratory distress syndrome KW - Risk assessment KW - Rupture KW - Ultrasound KW - Vagina KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017971824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=Vaginal+progesterone+reduces+the+rate+of+preterm+birth+in+women+with+a+sonographic+short+cervix%3A+a+multicenter%2C+randomized%2C+double-blind%2C+placebo-controlled+trial&rft.au=Hassan%2C+S+S%3BRomero%2C+R%3BVidyadhari%2C+D%3BFusey%2C+S%3BBaxter%2C+J+K%3BKhandelwal%2C+M%3BVijayaraghavan%2C+J%3BTrivedi%2C+Y%3BSoma-Pillay%2C+P%3BSambarey%2C+P%3BDayal%2C+A%3BPotapov%2C+V%3BO%27Brien%2C+J%3BAstakhov%2C+V%3BYuzko%2C+O%3BKinzler%2C+W%3BDattel%2C+B%3BSehdev%2C+H%3BMazheika%2C+L%3BManchulenko%2C+D%3BGervasi%2C+M+T%3BSullivan%2C+L%3BConde-Agudelo%2C+A%3BPhillips%2C+J+A%3BCreasy%2C+G+W&rft.aulast=Hassan&rft.aufirst=S&rft.date=2011-07-01&rft.volume=38&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=14690705&rft_id=info:doi/10.1002%2Fuog.9017 L2 - http://onlinelibrary.wiley.com/doi/10.1002/uog.9017/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Birth weight; Mortality; Motivation; Progesterone; Gynecology; Rupture; Morbidity; Pregnancy; Birth; Vagina; Gestation; Respiratory distress syndrome; Neonates; Cervix; Obstetrics; Ultrasound DO - http://dx.doi.org/10.1002/uog.9017 ER - TY - JOUR T1 - A novel microRNA mmu-miR-466h affects apoptosis regulation in mammalian cells AN - 1017967298; 16691921 AB - This study determined the changes in microRNA (miRs) expression in mammalian Chinese hamster ovary (CHO) cells undergoing apoptosis induced by exposing the cells to nutrient-depleted media. The apoptosis onset was confirmed by reduced cell viability and Caspase-3/7 activation. Microarray comparison of known mouse and rat miRs in CHO cells exposed to fresh or depleted media revealed up-regulation of the mouse miR-297-669 cluster in CHO cells subjected to depleted media. The mmu-miR-466h was chosen for further analysis as the member of this cluster with the highest overexpression and its up-regulation in depleted media was confirmed with qRT-PCR. Since miRs suppress mRNA translation, we hypothesized that up-regulated mmu-miR-466h inhibits anti-apoptotic genes and induces apoptosis. A combination of bioinformatics and experimental tools was used to predict and verify mmu-miR-466h anti-apoptotic targets. 8708 predicted targets were obtained from miRecords database and narrowed to 38 anti-apoptotic genes with DAVID NCBI annotation tool. Several genes were selected from this anti-apoptotic subset based on nucleotide pairing complimentarity between the mmu-miR-466h seed region and 3' UTR of the target mRNAs. The qRT-PCR analysis revealed reduced mRNA levels of bcl2l2, dad1, birc6, stat5a, and smo genes in CHO cells exposed to depleted media. The inhibition of the mmu-miR-466h increased the expression levels of those genes and resulted in increased cell viability and decreased Caspase-3/7 activation. The up-regulation of mmu-miR-466h in response to nutrients depletion causes the inhibition of several anti-apoptotic genes in unison. This suggests the pro-apoptotic role of mmu-miR-466h and its capability to modulate the apoptotic pathway in mammalian cells. Biotechnol. Bioeng. 2011; 108:1651-1661. ? 2011 Wiley Periodicals, Inc. JF - Biotechnology and Bioengineering AU - Druz, Aliaksandr AU - Chu, Chia AU - Majors, Brian AU - Santuary, Rodell AU - Betenbaugh, Michael AU - Shiloach, Joseph AD - Biotechnology Core Laboratory National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike Bldg 14A Rm 176, Bethesda, Maryland 20892; telephone: 301-496-9719, 301-402-2327; fax: 301-451-5911, beten@jhu.edu Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 1651 EP - 1661 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 108 IS - 7 SN - 1097-0290, 1097-0290 KW - Biochemistry Abstracts 2: Nucleic Acids; Water Resources Abstracts; Aqualine Abstracts; Biotechnology and Bioengineering Abstracts KW - Translation KW - Apoptosis KW - Nutrients KW - Mammalian cells KW - Regulations KW - Seeds KW - Depletion KW - miRNA KW - Inhibition KW - Nucleotides KW - Databases KW - Translations KW - Caspase-3 KW - Bioinformatics KW - Biotechnology KW - AQ 00001:Water Resources and Supplies KW - SW 0540:Properties of water KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017967298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+and+Bioengineering&rft.atitle=A+novel+microRNA+mmu-miR-466h+affects+apoptosis+regulation+in+mammalian+cells&rft.au=Druz%2C+Aliaksandr%3BChu%2C+Chia%3BMajors%2C+Brian%3BSantuary%2C+Rodell%3BBetenbaugh%2C+Michael%3BShiloach%2C+Joseph&rft.aulast=Druz&rft.aufirst=Aliaksandr&rft.date=2011-07-01&rft.volume=108&rft.issue=7&rft.spage=1651&rft.isbn=&rft.btitle=&rft.title=Biotechnology+and+Bioengineering&rft.issn=10970290&rft_id=info:doi/10.1002%2Fbit.23092 L2 - http://onlinelibrary.wiley.com/doi/10.1002/bit.23092/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Databases; Translation; Seeds; Apoptosis; Mammalian cells; miRNA; Caspase-3; Nutrients; Bioinformatics; Nucleotides; Translations; Depletion; Regulations; Inhibition; Biotechnology DO - http://dx.doi.org/10.1002/bit.23092 ER - TY - JOUR T1 - Does the individualized reference outperform a simple ultrasound-based reference applied to birth weight in predicting child neurodevelopment? AN - 1017962506; 16703807 AB - Objectives Being small-for-gestational age (SGA) is associated with an increased risk of morbidity, but questions remain about how best to diagnose SGA, and thus, predict poor health consequences. The authors sought to compare an individualized reference for defining SGA with simple birth weight-based and ultrasound-based references applied to birth weight in predicting poor cognitive development at age five. Methods The authors used data from the Successive SGA Births Study, a prospective study including 699 Alabaman and 618 Scandinavian women recruited from 1986 to 1988, and whose children had cognitive development scores measured at age five using the Wechsler Preschool and Primary Scale of Intelligence-Revised Intelligence Quotient. Sensitivity, specificity and positive predictive value (PPV) were estimated for each reference applied to birth weight using adverse cognitive development (score < 10th percentile) as the outcome. Relative risk of poor neurodevelopment was calculated, comparing infants classified as SGA by either the individualized or the simple ultrasound-based reference with infants not classified as SGA. Results The individualized reference had higher specificity and PPV in predicting poor neurodevelopment. Neonates defined as SGA by the individualized reference alone had a higher risk (RR = 2.20, 95% CI: 1.20, 4.00) of poor cognitive outcome, while those identified by the ultrasound-based reference alone did not (RR = 0.95, 95% CI: 0.45, 2.01). None of the references could predict poor neurodevelopment well at age five. Conclusions The individualized birth weight reference modestly outperforms the simple ultrasound-based reference in identifying SGA infants with poor child neurodevelopment. However, neither reference can predict child neurodevelopment well. JF - Ultrasound in Obstetrics and Gynecology AU - Neta, G AU - Grewal, J AU - Mikolajczyk, R AU - Klebanoff, M AU - Zhang, J AD - Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA, netagil@mail.nih.gov Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 62 EP - 66 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 38 IS - 1 SN - 1469-0705, 1469-0705 KW - Biotechnology and Bioengineering Abstracts KW - Age KW - Birth weight KW - Children KW - Cognitive ability KW - Data processing KW - Gynecology KW - Infants KW - Intelligence KW - Morbidity KW - Neonates KW - Obstetrics KW - Risk assessment KW - Risk factors KW - Small-for-gestational age KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017962506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=Does+the+individualized+reference+outperform+a+simple+ultrasound-based+reference+applied+to+birth+weight+in+predicting+child+neurodevelopment%3F&rft.au=Neta%2C+G%3BGrewal%2C+J%3BMikolajczyk%2C+R%3BKlebanoff%2C+M%3BZhang%2C+J&rft.aulast=Neta&rft.aufirst=G&rft.date=2011-07-01&rft.volume=38&rft.issue=1&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=14690705&rft_id=info:doi/10.1002%2Fuog.8902 L2 - http://onlinelibrary.wiley.com/doi/10.1002/uog.8902/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Birth weight; Age; Data processing; Gynecology; Small-for-gestational age; Children; Morbidity; Intelligence; Cognitive ability; Risk factors; Neonates; Obstetrics; Ultrasound; Infants DO - http://dx.doi.org/10.1002/uog.8902 ER - TY - JOUR T1 - Dietary nitrate and nitrite and the risk of thyroid cancer in the NIH-AARP Diet and Health Study AN - 1017962123; 16689935 AB - During the past several decades, an increasing incidence of thyroid cancer has been observed worldwide. Nitrate inhibits iodide uptake by the thyroid, potentially disrupting thyroid function. An increased risk of thyroid cancer associated with nitrate intake was recently reported in a cohort study of older women in Iowa. We evaluated dietary nitrate and nitrite intake and thyroid cancer risk overall and for subtypes in the National Institutes of Health-American Association of Retired Persons (NIH-AARP) Diet and Health Study, a large prospective cohort of 490,194 men and women, ages 50-71 years in 1995-1996. Dietary intakes were assessed using a 124-item food frequency questionnaire. During an average of 7 years of follow-up we identified 370 incident thyroid cancer cases (170 men, 200 women) with complete dietary information. Among men, increasing nitrate intake was positively associated with thyroid cancer risk (relative risk [RR] for the highest quintile versus lowest quintile RR = 2.28, 95% confidence interval [CI]: 1.29-4.041; p-trend <0.001); however, we observed no trend with intake among women (p-trend = 0.61). Nitrite intake was not associated with risk of thyroid cancer for either men or women. We evaluated risk for the two main types of thyroid cancer. We found positive associations for nitrate intake and both papillary (RR = 2.10; 95% CI: 1.09-4.05; p-trend = 0.05) and follicular thyroid cancer (RR = 3.42; 95% CI: 1.03-11.4; p-trend = 0.01) among men. Nitrite intake was associated with increased risk of follicular thyroid cancer (RR = 2.74; 95%CI: 0.86-8.77; p-trend = 0.04) among men. Our results support a role of nitrate in thyroid cancer risk and suggest that further studies to investigate these exposures are warranted. JF - International Journal of Cancer AU - Kilfoy, Briseis A AU - Zhang, Yawei AU - Park, Yikyung AU - Holford, Theodore R AU - Schatzkin, Arthur AU - Hollenbeck, Albert AU - Ward, Mary H AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, kilfoyb@mail.nih.gov Y1 - 2011/07/01/ PY - 2011 DA - 2011 Jul 01 SP - 160 EP - 172 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 129 IS - 1 SN - 1097-0215, 1097-0215 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Cancer KW - Diets KW - Ingestion KW - Iodides KW - Nitrates KW - Nitrites KW - Thyroid KW - iodides KW - USA, Iowa KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017962123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Dietary+nitrate+and+nitrite+and+the+risk+of+thyroid+cancer+in+the+NIH-AARP+Diet+and+Health+Study&rft.au=Kilfoy%2C+Briseis+A%3BZhang%2C+Yawei%3BPark%2C+Yikyung%3BHolford%2C+Theodore+R%3BSchatzkin%2C+Arthur%3BHollenbeck%2C+Albert%3BWard%2C+Mary+H&rft.aulast=Kilfoy&rft.aufirst=Briseis&rft.date=2011-07-01&rft.volume=129&rft.issue=1&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=10970215&rft_id=info:doi/10.1002%2Fijc.25650 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ijc.25650/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Diets; Iodides; Age; Nitrites; Nitrates; iodides; Thyroid; Ingestion; Cancer; USA, Iowa DO - http://dx.doi.org/10.1002/ijc.25650 ER - TY - JOUR T1 - A multi-proxy sediment record of late Holocene and Recent climate change from a lake near Ny-Alesund, Svalbard AN - 1008820684; 2012-040884 AB - The Arctic constitutes a unique and important environment with a significant role in the dynamics and evolution of the earth system. Arctic lake sediments, which accumulate slowly over time, contain abundant information about the biological communities that lived within the water body, as well as in the surrounding catchment. In this study, we collected a sediment core from Ny-Alesund, Svalbard, performed multi-proxy analyses on sediment pigments, mineral magnetic susceptibility, various sediment quality (i. e. organic matter content, CaCO (sub 3) content, carbon and nitrogen isotope), and diatom composition, and reconstructed the history of ecosystem responses to environmental variations, especially regarding aquatic productivity and lake catchment surface processes. Ny-Alesund has undergone distinct ecological and climatic changes. During the Little Ice Age, the cold climate was unfavourable for the growth of lake algae, and therefore the lake primary productivity declined. After about AD 1890 and during the 20th century, the warming climate and reduced ice cover led to rapid lithological change and growth of lake algae, enhanced lake primary productivity, and increased input of nutrients derived from increased chemical weathering into the lake. The lake ecosystem on Ny-Alesund has had rapid responses to climatic and environmental changes in the Arctic. JF - Boreas AU - Jiang, Shan AU - Liu, Xiaodong AU - Sun, Jing AU - Yuan, Linxi AU - Sun, Liguang AU - Wang, Yuhong Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 468 EP - 480 PB - Wiley-Blackwell, Oslo VL - 40 IS - 3 SN - 0300-9483, 0300-9483 KW - Spitsbergen Island KW - lithostratigraphy KW - Little Ice Age KW - Svalbard KW - isotopes KW - lead KW - Spitsbergen KW - Knudsenheia Lake KW - algae KW - Holocene KW - stable isotopes KW - cores KW - nitrogen KW - magnetic properties KW - Cenozoic KW - radioactive isotopes KW - diatoms KW - Ny-Alesund KW - silica KW - carbon KW - sediments KW - absolute age KW - ecology KW - Plantae KW - N-15/N-14 KW - Quaternary KW - assemblages KW - pigments KW - isotope ratios KW - Arctic region KW - grain size KW - C-13/C-12 KW - paleomagnetism KW - paleoenvironment KW - Neoglacial KW - metals KW - magnetic susceptibility KW - lacustrine environment KW - C-14 KW - upper Holocene KW - microfossils KW - Pb-210 KW - lake sediments KW - 24:Quaternary geology KW - 02D:Isotope geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1008820684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Boreas&rft.atitle=A+multi-proxy+sediment+record+of+late+Holocene+and+Recent+climate+change+from+a+lake+near+Ny-Alesund%2C+Svalbard&rft.au=Jiang%2C+Shan%3BLiu%2C+Xiaodong%3BSun%2C+Jing%3BYuan%2C+Linxi%3BSun%2C+Liguang%3BWang%2C+Yuhong&rft.aulast=Jiang&rft.aufirst=Shan&rft.date=2011-07-01&rft.volume=40&rft.issue=3&rft.spage=468&rft.isbn=&rft.btitle=&rft.title=Boreas&rft.issn=03009483&rft_id=info:doi/10.1111%2Fj.1502-3885.2010.00198.x L2 - http://www3.interscience.wiley.com/journal/118902553/home LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Date revised - 2012-01-01 N1 - Number of references - 82 N1 - Document feature - illus. incl. sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - BRESB3 N1 - SubjectsTermNotLitGenreText - absolute age; algae; Arctic region; assemblages; C-13/C-12; C-14; carbon; Cenozoic; cores; diatoms; ecology; grain size; Holocene; isotope ratios; isotopes; Knudsenheia Lake; lacustrine environment; lake sediments; lead; lithostratigraphy; Little Ice Age; magnetic properties; magnetic susceptibility; metals; microfossils; N-15/N-14; Neoglacial; nitrogen; Ny-Alesund; paleoenvironment; paleomagnetism; Pb-210; pigments; Plantae; Quaternary; radioactive isotopes; sediments; silica; Spitsbergen; Spitsbergen Island; stable isotopes; Svalbard; upper Holocene DO - http://dx.doi.org/10.1111/j.1502-3885.2010.00198.x ER - TY - JOUR T1 - Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity. AN - 874018606; 21540635 AB - Benzene, a recognized hematotoxicant and carcinogen, can damage the human immune system. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and benzene hematotoxicity in a cross-sectional study of workers exposed to benzene (250 workers and 140 controls). A total of 1,236 tag SNPs in 149 gene regions of six pathways were included in the analysis. Six gene regions were significant for their association with white blood cell (WBC) counts (MBP, VCAM1, ALOX5, MPO, RAC2, and CRP) based on gene-region (P<0.05) and SNP analyses (FDR<0.05). VCAM1 rs3176867, ALOX5 rs7099684, and MPO rs2071409 were the three most significant SNPs. They showed similar effects on WBC subtypes, especially granulocytes, lymphocytes, and monocytes. A 3-SNP block in ALOXE3 (rs7215658, rs9892383, and rs3027208) showed a global association (omnibus P = 0.0008) with WBCs even though the three SNPs were not significant individually. Our study suggests that polymorphisms in innate immunity genes may play a role in benzene-induced hematotoxicity; however, independent replication is necessary. JF - Experimental & molecular medicine AU - Shen, Min AU - Zhang, Luoping AU - Lee, Kyoung Mu AU - Vermeulen, Roel AU - Hosgood, H Dean AU - Li, Guilan AU - Yin, Songnian AU - Rothman, Nathaniel AU - Chanock, Stephen AU - Smith, Martyn T AU - Lan, Qing AD - Division of Cancer Epidemiology and Genetics NCI, NIH, DHHS, Bethesda MD 20892, U.S.A. Y1 - 2011/06/30/ PY - 2011 DA - 2011 Jun 30 SP - 374 EP - 378 VL - 43 IS - 6 KW - Vascular Cell Adhesion Molecule-1 KW - 0 KW - Peroxidase KW - EC 1.11.1.7 KW - Arachidonate 5-Lipoxygenase KW - EC 1.13.11.34 KW - Benzene KW - J64922108F KW - Index Medicus KW - Cross-Sectional Studies KW - Polymorphism, Single Nucleotide KW - Cell Count KW - Humans KW - Adult KW - Genetic Association Studies KW - Benzene -- toxicity KW - Occupational Exposure -- adverse effects KW - Immunity, Innate -- genetics KW - Genetic Predisposition to Disease KW - Male KW - Female KW - Hematologic Diseases -- genetics KW - Leukocytes -- metabolism KW - Peroxidase -- genetics KW - Peroxidase -- metabolism KW - Vascular Cell Adhesion Molecule-1 -- genetics KW - Hematologic Diseases -- metabolism KW - Arachidonate 5-Lipoxygenase -- genetics KW - Leukocytes -- drug effects KW - Hematologic Diseases -- chemically induced KW - Arachidonate 5-Lipoxygenase -- metabolism KW - Vascular Cell Adhesion Molecule-1 -- metabolism KW - Leukocytes -- pathology KW - Hematologic Diseases -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874018606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+%26+molecular+medicine&rft.atitle=Polymorphisms+in+genes+involved+in+innate+immunity+and+susceptibility+to+benzene-induced+hematotoxicity.&rft.au=Shen%2C+Min%3BZhang%2C+Luoping%3BLee%2C+Kyoung+Mu%3BVermeulen%2C+Roel%3BHosgood%2C+H+Dean%3BLi%2C+Guilan%3BYin%2C+Songnian%3BRothman%2C+Nathaniel%3BChanock%2C+Stephen%3BSmith%2C+Martyn+T%3BLan%2C+Qing&rft.aulast=Shen&rft.aufirst=Min&rft.date=2011-06-30&rft.volume=43&rft.issue=6&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=Experimental+%26+molecular+medicine&rft.issn=2092-6413&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-14 N1 - Date created - 2011-06-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Invest Dermatol. 2000 Aug;115(2):168-76 [10951232] Blood. 2008 Sep 1;112(5):1767-75 [18579797] J Natl Cancer Inst. 2004 Mar 17;96(6):434-42 [15026468] Leuk Lymphoma. 2004 Jan;45(1):35-48 [15061195] Biochim Biophys Acta. 2004 Sep 6;1690(1):11-21 [15337166] Biometrics. 1986 Mar;42(1):121-30 [3719049] Occup Med. 1988 Jul-Sep;3(3):541-54 [3043738] Contact Dermatitis. 1992 Aug;27(2):90-7 [1395635] Mol Biol Evol. 1995 Sep;12(5):921-7 [7476138] Cancer Res. 1997 Jul 15;57(14):2839-42 [9230185] Science. 2004 Dec 3;306(5702):1774-6 [15576619] Immunol Lett. 2005 Jun 15;99(1):24-9 [15894107] Cancer Res. 2005 Oct 15;65(20):9574-81 [16230423] Genet Epidemiol. 2006 Sep;30(6):495-507 [16755536] Curr Opin Immunol. 2007 Feb;19(1):1-3 [17157490] Mol Cells. 2007 Apr 30;23(2):198-206 [17464197] Genet Epidemiol. 2007 Dec;31(8):803-12 [17549762] Environ Health Perspect. 2003 Aug;111(11):1411-20 [12928149] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Different Requirements for [sigma] Region 4 in BvgA Activation of the Bordetella pertussis Promoters P sub(fim3 and P) sub(f)haB AN - 899142206; 15120990 AB - Bordetella pertussis BvgA is a global response regulator that activates virulence genes, including adhesin-encoding fim3 and fhaB. At the fhaB promoter, P sub(fhaB, a BvgA binding site lies immediately upstream of the - 35 promoter element recognized by Region 4 of the [sigma] subunit of RNA polymerase (RNAP). We demonstrate that [sigma] Region 4 is required for BvgA activation of P) sub(f)haB, a hallmark of Class II activation. In contrast, the promoter-proximal BvgA binding site at P sub(fim3 includes the - 35 region, which is composed of a tract of cytosines that lacks specific sequence information. We demonstrate that [sigma] Region 4 is not required for BvgA activation at P) sub(f)im3. Nonetheless, Region 4 mutations that impair its typical interactions with core and with the - 35 DNA affect P sub(fim3 transcription. Hydroxyl radical cleavage using RNAP with [sigma]D581C-FeBABE positions Region 4 near the - 35 region of P) sub(f)im3; cleavage using RNAP with alpha 276C-FeBABE or alpha 302C-FeBABE also positions an alpha subunit C-terminal domain within the - 35 region, on a different helical face from the promoter-proximal BvgA~P dimer. Our results suggest that the - 35 region of P sub(fim3 accommodates a BvgA~P dimer, an alpha subunit C-terminal domain, and [sigma] Region 4. Molecular modeling suggests how BvgA, [sigma] Region 4, and alpha might coexist within this DNA in a conformation that suggests a novel mechanism of activation.) JF - Journal of Molecular Biology AU - Decker, Kimberly B AU - Chen, Qing AU - Hsieh, Meng-Lun AU - Boucher, Philip AU - Stibitz, Scott AU - Hinton, Deborah M Y1 - 2011/06/24/ PY - 2011 DA - 2011 Jun 24 SP - 692 EP - 709 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 409 IS - 5 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts B: Bacteriology KW - Pertussis KW - Molecular modelling KW - Free radicals KW - Transcription KW - Virulence KW - Promoters KW - Cytosine KW - Bordetella pertussis KW - DNA-directed RNA polymerase KW - DNA KW - Mutation KW - Conformation KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899142206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Different+Requirements+for+%5Bsigma%5D+Region+4+in+BvgA+Activation+of+the+Bordetella+pertussis+Promoters+P+sub%28fim3+and+P%29+sub%28f%29haB&rft.au=Decker%2C+Kimberly+B%3BChen%2C+Qing%3BHsieh%2C+Meng-Lun%3BBoucher%2C+Philip%3BStibitz%2C+Scott%3BHinton%2C+Deborah+M&rft.aulast=Decker&rft.aufirst=Kimberly&rft.date=2011-06-24&rft.volume=409&rft.issue=5&rft.spage=692&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2011.04.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Virulence; Cytosine; Molecular modelling; Pertussis; Promoters; DNA-directed RNA polymerase; Free radicals; DNA; Transcription; Mutation; Conformation; Bordetella pertussis DO - http://dx.doi.org/10.1016/j.jmb.2011.04.017 ER - TY - JOUR T1 - Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells. AN - 872437305; 21539383 AB - Nrf2-mediated activation of antioxidant response element is a central part of molecular mechanisms governing the protective function of phase II detoxification and antioxidant enzymes against carcinogenesis, oxidative stress, and inflammation. Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. We have designed and synthesized novel chalcone derivatives as Nrf2 activators. The potency of these compounds was measured by the expression of Nrf2 dependent antioxidant genes GCLM, NQO1, and HO1 in human lung epithelial cells, while the cytotoxicity was analyzed using MTT assay. In vivo potency of identified lead compounds to activate Nrf2 was evaluated using a mouse model. Our studies showed 2-trifluoromethyl-2'-methoxychalone (2b) to be a potent activator of Nrf2, both in vitro and in mice. Additional experiments showed that the activation of Nrf2 by this compound is independent of reactive oxygen species or redox changes. We have discussed a quantitative structure-activity relationship and proposed a possible mechanism of Nrf2 activation. JF - Journal of medicinal chemistry AU - Kumar, Vineet AU - Kumar, Sarvesh AU - Hassan, Mohammad AU - Wu, Hailong AU - Thimmulappa, Rajesh K AU - Kumar, Amit AU - Sharma, Sunil K AU - Parmar, Virinder S AU - Biswal, Shyam AU - Malhotra, Sanjay V AD - Laboratory of Synthetic Chemistry, SAIC Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland 21702, United States. Y1 - 2011/06/23/ PY - 2011 DA - 2011 Jun 23 SP - 4147 EP - 4159 VL - 54 IS - 12 KW - 2-trifluoromethyl-2'-methoxychalone KW - 0 KW - Chalcones KW - Enzyme Activators KW - NF-E2-Related Factor 2 KW - Reactive Oxygen Species KW - HMOX1 protein, human KW - EC 1.14.14.18 KW - Heme Oxygenase-1 KW - NAD(P)H Dehydrogenase (Quinone) KW - EC 1.6.5.2 KW - NQO1 protein, human KW - Glutamate-Cysteine Ligase KW - EC 6.3.2.2 KW - glutamate-cysteine ligase modifier subunit, human KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Glutamate-Cysteine Ligase -- genetics KW - Stereoisomerism KW - Heme Oxygenase-1 -- biosynthesis KW - NAD(P)H Dehydrogenase (Quinone) -- biosynthesis KW - Humans KW - Transcription, Genetic KW - Glutamate-Cysteine Ligase -- biosynthesis KW - Heme Oxygenase-1 -- genetics KW - Mice KW - Oxidation-Reduction KW - NAD(P)H Dehydrogenase (Quinone) -- genetics KW - Quantitative Structure-Activity Relationship KW - Cell Survival -- drug effects KW - Mice, Inbred C57BL KW - Cell Line KW - Male KW - Epithelial Cells -- metabolism KW - Enzyme Activators -- chemistry KW - Epithelial Cells -- drug effects KW - Chalcones -- chemical synthesis KW - Bronchi -- cytology KW - Enzyme Activators -- chemical synthesis KW - Chalcones -- pharmacology KW - Chalcones -- chemistry KW - Bronchi -- metabolism KW - Bronchi -- drug effects KW - Enzyme Activators -- pharmacology KW - NF-E2-Related Factor 2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872437305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Novel+chalcone+derivatives+as+potent+Nrf2+activators+in+mice+and+human+lung+epithelial+cells.&rft.au=Kumar%2C+Vineet%3BKumar%2C+Sarvesh%3BHassan%2C+Mohammad%3BWu%2C+Hailong%3BThimmulappa%2C+Rajesh+K%3BKumar%2C+Amit%3BSharma%2C+Sunil+K%3BParmar%2C+Virinder+S%3BBiswal%2C+Shyam%3BMalhotra%2C+Sanjay+V&rft.aulast=Kumar&rft.aufirst=Vineet&rft.date=2011-06-23&rft.volume=54&rft.issue=12&rft.spage=4147&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm2002348 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-16 N1 - Date created - 2011-06-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Med Chem. 2008 Oct 9;51(19):6230-4 [18798609] Eur J Med Chem. 2008 Oct;43(10):2220-8 [18280009] Planta Med. 2008 Oct;74(13):1526-39 [18937164] J Pharm Pharmacol. 2000 Feb;52(2):163-71 [10714946] Bioorg Med Chem Lett. 2000 Apr 17;10(8):699-701 [10782667] Free Radic Biol Med. 2001 Jan 1;30(1):43-50 [11134894] J Comb Chem. 2001 Mar-Apr;3(2):224-8 [11300864] FASEB J. 2001 Jul;15(9):1569-74 [11427489] Mutat Res. 2001 Sep 1;480-481:305-15 [11506823] J Biol Chem. 2001 Aug 24;276(34):32008-15 [11410599] Eur J Med Chem. 2001 Jun;36(6):555-60 [11525846] J Med Chem. 2001 Dec 6;44(25):4443-52 [11728189] Pharmacogenetics. 2002 Mar;12(2):175-9 [11875371] Mol Cell Biol. 2002 May;22(9):2883-92 [11940647] Oncogene. 2002 Mar 28;21(14):2191-200 [11948402] Bioorg Med Chem. 2002 Aug;10(8):2795-802 [12057669] Bioorg Med Chem Lett. 2002 Aug 5;12(15):1951-4 [12113816] Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11908-13 [12193649] Cancer Res. 2002 Sep 15;62(18):5196-203 [12234984] Annu Rev Pharmacol Toxicol. 2003;43:233-60 [12359864] J Biol Chem. 2003 Mar 7;278(10):8135-45 [12506115] Biochem J. 2003 May 1;371(Pt 3):887-95 [12570874] Phytomedicine. 2003 Mar;10(2-3):189-95 [12725575] J Biol Chem. 2003 Jun 13;278(24):21592-600 [12682069] J Biol Chem. 2003 Jul 11;278(28):26046-54 [12709421] Biochem J. 2003 Sep 1;374(Pt 2):337-48 [12816537] Biochem Pharmacol. 2004 Apr 15;67(8):1549-57 [15041472] J Biol Chem. 2004 May 7;279(19):20108-17 [14978030] Cancer Sci. 2004 May;95(5):448-53 [15132774] J Agric Food Chem. 2004 Jun 2;52(11):3297-300 [15161186] Biochem Biophys Res Commun. 1983 May 16;112(3):833-42 [6303339] Stem Cells. 1994 Jan;12(1):44-52 [8142919] Anticancer Drug Des. 1995 Sep;10(6):481-90 [7575989] Pharm Res. 1998 Jan;15(1):39-46 [9487544] J Med Chem. 1998 Oct 8;41(21):4161-4 [9767651] Bioorg Med Chem Lett. 1998 May 19;8(10):1169-74 [9871729] J Biol Chem. 1999 Sep 24;274(39):27545-52 [10488090] Curr Med Chem. 1999 Dec;6(12):1125-49 [10519918] J Pharmacol Exp Ther. 2005 Feb;312(2):686-93 [15537827] Curr Med Chem. 2005;12(4):481-99 [15720256] Cancer Lett. 2005 Jun 28;224(2):171-84 [15914268] J Exp Med. 2005 Jul 4;202(1):47-59 [15998787] J Pharmacol Exp Ther. 2006 Jan;316(1):271-8 [16183703] Bioorg Med Chem. 2006 Mar 15;14(6):1710-4 [16263298] Toxicol Appl Pharmacol. 2006 Aug 1;214(3):244-52 [16480751] Am J Respir Cell Mol Biol. 2006 Dec;35(6):639-50 [16794261] PLoS Med. 2006 Oct;3(10):e420 [17020408] Annu Rev Pharmacol Toxicol. 2007;47:89-116 [16968214] Life Sci. 2007 Mar 20;80(15):1420-30 [17320913] Bioorg Med Chem. 2007 Apr 15;15(8):2952-62 [17321745] Eur J Med Chem. 2007 May;42(5):660-8 [17320246] Inhal Toxicol. 2007;19 Suppl 1:177-82 [17886065] Physiol Genomics. 2007 Nov 14;31(3):429-40 [17726092] Toxicol Sci. 2008 Jul;104(1):218-27 [18417483] Bioorg Med Chem. 2008 Aug 1;16(15):7270-6 [18606546] Cancer Res. 2008 Oct 1;68(19):7975-84 [18829555] Med Chem. 2008 Nov;4(6):586-96 [18991744] Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):250-5 [19104057] Hepatology. 2009 Apr;49(4):1316-25 [19177595] J Biol Chem. 2009 May 15;284(20):13291-5 [19182219] Ann N Y Acad Sci. 2009 Aug;1171:399-406 [19723082] J Cell Sci. 2009 Dec 15;122(Pt 24):4452-64 [19920073] Curr Clin Pharmacol. 2010 Feb;5(1):1-29 [19891604] Free Radic Biol Med. 2010 May 15;48(10):1410-22 [20188821] Biochem Biophys Res Commun. 2010 May 28;396(2):463-6 [20417615] Methods Mol Biol. 2010;647:37-74 [20694660] Med Chem. 2010 May;6(3):174-83 [20632977] Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18838-43 [20956331] Bioorg Med Chem Lett. 1998 May 5;8(9):1051-6 [9871706] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm2002348 ER - TY - JOUR T1 - Novel protection-deprotection strategies in diazeniumdiolate chemistry: synthesis of V-IPA/NO. AN - 869795357; 21556407 AB - Synthesis of previously inaccessible, potentially liver selective HNO donor V-IPA/NO ([iPrHN(3)-N(1)(O(1))=N(2)-O(2)-R], where R = vinyl) is reported here. A novel fluoride-labile TOM group at O-2 in conjunction with MOM protection at N-3 in IPA/NO is employed. The strategy developed is also extended to synthesis of other NO-releasing prodrugs and has applications in diversity-oriented synthesis of HNO- and NO-prodrugs. This journal is © The Royal Society of Chemistry 2011 JF - Chemical communications (Cambridge, England) AU - Nandurdikar, Rahul S AU - Keefer, Larry K AU - Saavedra, Joseph E AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA. nandurdikarr@mail.nih.gov Y1 - 2011/06/21/ PY - 2011 DA - 2011 Jun 21 SP - 6710 EP - 6712 VL - 47 IS - 23 KW - Azo Compounds KW - 0 KW - Nitrogen Oxides KW - Prodrugs KW - Vinyl Compounds KW - diazeniumdiolate KW - Nitric Oxide KW - 31C4KY9ESH KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - nitroxyl KW - GFQ4MMS07W KW - Index Medicus KW - Prodrugs -- chemistry KW - Nitrogen Oxides -- chemistry KW - Cytochrome P-450 Enzyme System -- chemistry KW - Cytochrome P-450 Enzyme System -- metabolism KW - Nitric Oxide -- chemistry KW - Prodrugs -- chemical synthesis KW - Vinyl Compounds -- chemistry KW - Azo Compounds -- chemistry KW - Vinyl Compounds -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869795357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+communications+%28Cambridge%2C+England%29&rft.atitle=Novel+protection-deprotection+strategies+in+diazeniumdiolate+chemistry%3A+synthesis+of+V-IPA%2FNO.&rft.au=Nandurdikar%2C+Rahul+S%3BKeefer%2C+Larry+K%3BSaavedra%2C+Joseph+E&rft.aulast=Nandurdikar&rft.aufirst=Rahul&rft.date=2011-06-21&rft.volume=47&rft.issue=23&rft.spage=6710&rft.isbn=&rft.btitle=&rft.title=Chemical+communications+%28Cambridge%2C+England%29&rft.issn=1364-548X&rft_id=info:doi/10.1039%2Fc1cc12130h LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-28 N1 - Date created - 2011-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1039/c1cc12130h ER - TY - JOUR T1 - Mispairing C57BL/6 substrains of genetically engineered mice and wild-type controls can lead to confounding results as it did in studies of JNK2 in acetaminophen and concanavalin A liver injury. AN - 873123818; 21557537 AB - C57BL/6 mice are widely used in biomedical research for the background of genetically engineered mice (GEM) and wild-type controls with the belief that the genetic background of GEM and control mice differ significantly by only one or more altered genes. This principle, however, does have limitations due in part to the existence of multiple substrains of C57BL/6 mice that should not be used interchangeably as they can differ both genetically and phenotypically. We show here that these mispairings do occur frequently and can lead to inaccurate and conflicting findings. JF - Chemical research in toxicology AU - Bourdi, Mohammed AU - Davies, John S AU - Pohl, Lance R AD - Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-1760, United States. bourdim@nhlbi.nih.gov Y1 - 2011/06/20/ PY - 2011 DA - 2011 Jun 20 SP - 794 EP - 796 VL - 24 IS - 6 KW - Analgesics, Non-Narcotic KW - 0 KW - Mitogens KW - Concanavalin A KW - 11028-71-0 KW - Acetaminophen KW - 362O9ITL9D KW - Mitogen-Activated Protein Kinase 9 KW - EC 2.7.1.24 KW - Index Medicus KW - Genotype KW - Animals KW - Gene Knockdown Techniques KW - Mice KW - Mice, Knockout KW - Mitogen-Activated Protein Kinase 9 -- genetics KW - Mice, Inbred C57BL -- genetics KW - Concanavalin A -- toxicity KW - Chemical and Drug Induced Liver Injury -- pathology KW - Chemical and Drug Induced Liver Injury -- genetics KW - Analgesics, Non-Narcotic -- toxicity KW - Mitogens -- toxicity KW - Chemical and Drug Induced Liver Injury -- enzymology KW - Acetaminophen -- toxicity KW - Mice, Transgenic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/873123818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Mispairing+C57BL%2F6+substrains+of+genetically+engineered+mice+and+wild-type+controls+can+lead+to+confounding+results+as+it+did+in+studies+of+JNK2+in+acetaminophen+and+concanavalin+A+liver+injury.&rft.au=Bourdi%2C+Mohammed%3BDavies%2C+John+S%3BPohl%2C+Lance+R&rft.aulast=Bourdi&rft.aufirst=Mohammed&rft.date=2011-06-20&rft.volume=24&rft.issue=6&rft.spage=794&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx200143x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-14 N1 - Date created - 2011-06-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arterioscler Thromb Vasc Biol. 2000 Jun;20(6):1425-9 [10845854] Transgenic Res. 2011 Jun;20(3):481-9 [20506040] Genes Brain Behav. 2004 Jun;3(3):149-57 [15140010] Cancer Lett. 1980 Apr;9(2):111-5 [7379041] Cell Immunol. 1987 Dec;110(2):294-304 [2446778] Hum Mol Genet. 2006 Apr 1;15(7):1187-94 [16497723] Gastroenterology. 2006 Jul;131(1):165-78 [16831600] Chem Res Toxicol. 2007 May;20(5):734-44 [17439248] Gut. 2007 Jul;56(7):982-90 [17185352] Alcohol Clin Exp Res. 2007 Oct;31(10):1669-76 [17651469] Genome Res. 2008 Jan;18(1):60-6 [18032724] J Biol Chem. 2008 May 16;283(20):13565-77 [18337250] Biochem Biophys Res Commun. 2008 Sep 12;374(1):6-10 [18586006] Genes Brain Behav. 2008 Aug;7(6):677-89 [18397380] Am J Pathol. 2008 Oct;173(4):962-72 [18772342] Gastroenterology. 2008 Oct;135(4):1311-21 [18700144] J Neurogenet. 2008;22(4):315-31 [19085272] Exp Anim. 2009 Apr;58(2):141-9 [19448337] Br J Nutr. 2010 Feb;103(4):513-21 [19840420] Behav Genet. 2010 Mar;40(2):201-10 [20033273] Obesity (Silver Spring). 2010 Oct;18(10):1902-5 [20057372] Comp Med. 2000 Jun;50(3):288-91 [10894494] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/tx200143x ER - TY - JOUR T1 - Chlamydia pneumoniae Inhibits Activated Human T Lymphocyte Proliferation by the Induction of Apoptotic and Pyroptotic Pathways AN - 904474190; 14957413 AB - Chlamydia pneumoniae is an omnipresent obligate intracellular bacterial pathogen that infects numerous host species. C. pneumoniae infections of humans are a common cause of community acquired pneumonia but have also been linked to chronic diseases such as atherosclerosis, Alzheimer's disease, and asthma. Persistent infection and immune avoidance are believed to play important roles in the pathophysiology of C. pneumoniae disease. We found that C. pneumoniae organisms inhibited activated but not nonactivated human T cell proliferation. Inhibition of proliferation was pathogen specific, heat sensitive, and multiplicity of infection dependent and required chlamydial entry but not de novo protein synthesis. Activated CD4+ and CD8+ T cells were equally sensitive to C. pneumoniae antiproliferative effectors. The C. pneumoniae antiproliferative effect was linked to T cell death associated with caspase 1, 8, 9, and IL-1 beta production, indicating that both apoptotic and pyroptotic cellular death pathways were activated after pathogen-T cell interactions. Collectively, these findings are consistent with the conclusion that C. pneumoniae could induce a local T cell immunosuppression and inflammatory response revealing a possible host-pathogen scenario that would support both persistence and inflammation. JF - Journal of Immunology AU - Olivares-Zavaleta, Norma AU - Carmody, Aaron AU - Messer, Ronald AU - Whitmire, William M AU - Caldwell, Harlan D AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840 Y1 - 2011/06/15/ PY - 2011 DA - 2011 Jun 15 SP - 7120 EP - 7126 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA VL - 186 IS - 12 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Protein biosynthesis KW - Apoptosis KW - Alzheimer's disease KW - Interleukin 1 KW - Asthma KW - CD8 antigen KW - Arteriosclerosis KW - Pathogens KW - Persistent infection KW - Inflammation KW - Neurodegenerative diseases KW - CD4 antigen KW - Heat KW - Chronic infection KW - Lymphocytes T KW - Caspase-1 KW - Cell interactions KW - Chlamydophila pneumoniae KW - Cell proliferation KW - Multiplicity of infection KW - Pneumonia KW - Immunosuppression KW - F 06925:Hypersensitivity KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904474190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Chlamydia+pneumoniae+Inhibits+Activated+Human+T+Lymphocyte+Proliferation+by+the+Induction+of+Apoptotic+and+Pyroptotic+Pathways&rft.au=Olivares-Zavaleta%2C+Norma%3BCarmody%2C+Aaron%3BMesser%2C+Ronald%3BWhitmire%2C+William+M%3BCaldwell%2C+Harlan+D&rft.aulast=Olivares-Zavaleta&rft.aufirst=Norma&rft.date=2011-06-15&rft.volume=186&rft.issue=12&rft.spage=7120&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Apoptosis; Protein biosynthesis; Interleukin 1; Alzheimer's disease; Asthma; Pathogens; Arteriosclerosis; CD8 antigen; Persistent infection; Inflammation; Neurodegenerative diseases; CD4 antigen; Heat; Chronic infection; Lymphocytes T; Caspase-1; Cell interactions; Multiplicity of infection; Cell proliferation; Pneumonia; Immunosuppression; Chlamydophila pneumoniae ER - TY - JOUR T1 - In vitro studies of DNA mismatch repair proteins. AN - 863429246; 21329650 AB - The ability to monitor and characterize DNA mismatch repair activity in various mammalian cells is important for understanding mechanisms involved in mutagenesis and tumorigenesis. Since mismatch repair proteins recognize mismatches containing both normal and chemically altered or damaged bases, in vitro assays must accommodate a variety of mismatches in different sequence contexts. Here we describe the construction of DNA mismatch substrates containing G:T or O(6)meG:T mismatches, the purification of recombinant native human MutSα (MSH2-MSH6) and MutLα (MLH1-PMS2) proteins, and in vitro mismatch repair and excision assays that can be adapted to study mismatch repair in nuclear extracts from mismatch repair proficient and deficient cells. Published by Elsevier Inc. JF - Analytical biochemistry AU - Geng, Hui AU - Du, Chunwei AU - Chen, Siying AU - Salerno, Vincenzo AU - Manfredi, Candela AU - Hsieh, Peggy AD - Genetics & Biochemistry Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2011/06/15/ PY - 2011 DA - 2011 Jun 15 SP - 179 EP - 184 VL - 413 IS - 2 KW - DNA-Binding Proteins KW - 0 KW - G-T mismatch-binding protein KW - MutLalpha protein, human KW - Polynucleotides KW - Recombinant Proteins KW - MutL Proteins KW - EC 3.6.1.3 KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Index Medicus KW - Polynucleotides -- chemistry KW - Base Sequence KW - DNA-Binding Proteins -- chemistry KW - Humans KW - Polynucleotides -- metabolism KW - DNA-Binding Proteins -- isolation & purification KW - Cell Line KW - DNA-Binding Proteins -- metabolism KW - DNA Repair Enzymes -- metabolism KW - Recombinant Proteins -- isolation & purification KW - DNA Mismatch Repair KW - Recombinant Proteins -- metabolism KW - Recombinant Proteins -- chemistry KW - DNA Repair Enzymes -- isolation & purification KW - DNA Repair Enzymes -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863429246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+biochemistry&rft.atitle=In+vitro+studies+of+DNA+mismatch+repair+proteins.&rft.au=Geng%2C+Hui%3BDu%2C+Chunwei%3BChen%2C+Siying%3BSalerno%2C+Vincenzo%3BManfredi%2C+Candela%3BHsieh%2C+Peggy&rft.aulast=Geng&rft.aufirst=Hui&rft.date=2011-06-15&rft.volume=413&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Analytical+biochemistry&rft.issn=1096-0309&rft_id=info:doi/10.1016%2Fj.ab.2011.02.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-04 N1 - Date created - 2011-04-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2002 Jul 19;277(29):26136-42 [12006560] Mol Cell. 2003 Nov;12(5):1077-86 [14636568] Proc Natl Acad Sci U S A. 1979 Feb;76(2):655-9 [284391] Proc Natl Acad Sci U S A. 1990 Aug;87(15):5837-41 [2116007] J Biol Chem. 1991 Feb 25;266(6):3744-51 [1995629] Cold Spring Harb Symp Quant Biol. 1993;58:597-603 [7956074] Anal Biochem. 2009 May 1;388(1):167-9 [19248754] Annu Rev Biochem. 2005;74:681-710 [15952900] Cell. 2005 Sep 9;122(5):693-705 [16143102] Chem Rev. 2006 Feb;106(2):302-23 [16464007] Mol Cell. 2006 May 19;22(4):501-10 [16713580] Mech Ageing Dev. 2008 Jul-Aug;129(7-8):391-407 [18406444] Science. 1995 Jun 30;268(5219):1909-12 [7604264] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ab.2011.02.017 ER - TY - JOUR T1 - Alcohol and endometrial cancer risk in the NIH-AARP diet and health study AN - 1017965888; 16689964 AB - Previous investigations have provided conflicting results regarding whether alcohol consumption affects endometrial cancer risk, although in many of these studies the highest category of alcohol intake examined was limited. Further, most were unable to resolve how alcohol associations are affected by beverage type, the presence of other endometrial cancer risk factors, or tumor characteristics. To address these issues, we prospectively evaluated the association between alcohol intake and incident endometrial cancer (n = 1,491) in a cohort of 114,414 US women enrolled in the NIH-AARP Diet and Health Study. We calculated relative risks (RR) and 95% confidence intervals (CI) using Cox proportional hazards regression. After adjustment for age, body mass index (BMI), smoking and other potential confounders, the multivariable RRs (and 95% CIs) compared with nondrinkers were 0.97 (0.87-1.09) for >0-=24 g/day (p trend = 0.90). There was, however, some suggestion of higher risks associated with alcohol consumption among lean women (BMI, <25) and users of menopausal hormone therapy, with significant interactions with both parameters (respective interaction p-values of 0.002 and 0.005). The relationship was also enhanced, albeit nonsignificantly so, for low grade cancers. Our results do not support that alcohol is a strong contributor to endometrial cancer risk, but slight risk increases may prevail among some users or for selected tumor characteristics. JF - International Journal of Cancer AU - Yang, Hannah P AU - Gierach, Gretchen L AU - Danforth, Kim N AU - Sherman, Mark E AU - Park, Yikyung AU - Wentzensen, Nicolas AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Brinton, Louise A AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, yanghan@mail.nih.gov Y1 - 2011/06/15/ PY - 2011 DA - 2011 Jun 15 SP - 2953 EP - 2961 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 128 IS - 12 SN - 1097-0215, 1097-0215 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Alcohol KW - Body mass KW - Cancer KW - Diets KW - Hormones KW - Risk factors KW - Smoking KW - Tumors KW - body mass KW - tumors KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017965888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Alcohol+and+endometrial+cancer+risk+in+the+NIH-AARP+diet+and+health+study&rft.au=Yang%2C+Hannah+P%3BGierach%2C+Gretchen+L%3BDanforth%2C+Kim+N%3BSherman%2C+Mark+E%3BPark%2C+Yikyung%3BWentzensen%2C+Nicolas%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BBrinton%2C+Louise+A&rft.aulast=Yang&rft.aufirst=Hannah&rft.date=2011-06-15&rft.volume=128&rft.issue=12&rft.spage=2953&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=10970215&rft_id=info:doi/10.1002%2Fijc.25623 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ijc.25623/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Diets; Smoking; Alcohol; Age; body mass; Body mass; Risk factors; tumors; Tumors; Hormones; Cancer DO - http://dx.doi.org/10.1002/ijc.25623 ER - TY - JOUR T1 - Benefit/Risk Assessment for Breast Cancer Chemoprevention With Raloxifene or Tamoxifen for Women Age 50 Years or Older AN - 907163594; 14988422 AB - PURPOSE: The Study of Tamoxifen and Raloxifene (STAR) demonstrated that raloxifene was as effective as tamoxifen in reducing the risk of invasive breast cancer (IBC) in postmenopausal women and had lower risks of thromboembolic events, endometrial cancer, and cataracts but had a nonstatistically significant higher risk of noninvasive breast cancer. There is a need to summarize the risks and benefits of these agents. PATIENTS AND METHODS: Baseline incidence rates of IBC and other health outcomes, absent raloxifene and tamoxifen, were estimated from breast cancer chemoprevention trials; the Surveillance, Epidemiology and End Results Program; and the Women's Health Initiative. Effects of raloxifene and tamoxifen were estimated from STAR and the Breast Cancer Prevention Trial. We assigned weights to health outcomes to calculate the net benefit from raloxifene compared with placebo and tamoxifen compared with placebo. RESULTS: Risks and benefits of treatment with raloxifene or tamoxifen depend on age, race, breast cancer risk, and history of hysterectomy. Over a 5-year period, postmenopausal women with an intact uterus had a better benefit/risk index for raloxifene than for tamoxifen. For postmenopausal women without a uterus, the benefit/risk ratio was similar. The benefits and risks of raloxifene and tamoxifen are described in tables that can help identify groups of women for whom the benefits outweigh the risks. CONCLUSION: We developed a benefit/risk index to quantify benefits from chemoprevention with tamoxifen or raloxifene. This index can complement clinical evaluation in deciding whether to initiate chemoprevention and in comparing the benefits and risks of raloxifene versus tamoxifen. JF - Journal of Clinical Oncology AU - Freedman, Andrew N AU - Yu, Binbing AU - Gail, Mitchell H AU - Costantino, Joseph P AU - Graubard, Barry I AU - Vogel, Victor G AU - Anderson, Garnet L AU - McCaskill-Stevens, Worta AD - From the National Cancer Institute Y1 - 2011/06/10/ PY - 2011 DA - 2011 Jun 10 SP - 2327 EP - 2333 PB - American Society of Clinical Oncology VL - 29 IS - 17 SN - 0732-183X, 0732-183X KW - Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Breast cancer KW - Cancer KW - Chemotherapy KW - Females KW - Post-menopause KW - Prevention KW - Risk assessment KW - Risk reduction KW - chemotherapy KW - post-menopause KW - prevention KW - risk reduction KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907163594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Oncology&rft.atitle=Benefit%2FRisk+Assessment+for+Breast+Cancer+Chemoprevention+With+Raloxifene+or+Tamoxifen+for+Women+Age+50+Years+or+Older&rft.au=Freedman%2C+Andrew+N%3BYu%2C+Binbing%3BGail%2C+Mitchell+H%3BCostantino%2C+Joseph+P%3BGraubard%2C+Barry+I%3BVogel%2C+Victor+G%3BAnderson%2C+Garnet+L%3BMcCaskill-Stevens%2C+Worta&rft.aulast=Freedman&rft.aufirst=Andrew&rft.date=2011-06-10&rft.volume=29&rft.issue=17&rft.spage=2327&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Risk assessment; Age; post-menopause; Chemotherapy; Risk reduction; Cancer; chemotherapy; risk reduction; Prevention; Post-menopause; prevention; Breast cancer; Females ER - TY - JOUR T1 - A BLOC-1 Mutation Screen Reveals that PLDN Is Mutated in Hermansky-Pudlak Syndrome Type 9 AN - 876244281; 15113842 AB - Hermansky-Pudlak Syndrome (HPS) is an autosomal-recessive condition characterized by oculocutaneous albinism and a bleeding diathesis due to absent platelet delta granules. HPS is a genetically heterogeneous disorder of intracellular vesicle biogenesis. We first screened all our patients with HPS-like symptoms for mutations in the genes responsible for HPS-1 through HPS-6 and found no functional mutations in 38 individuals. We then examined all eight genes encoding the biogenesis of lysosome-related organelles complex-1, or BLOC-1, proteins in these individuals. This identified a homozygous nonsense mutation in PLDN in a boy with characteristic features of HPS. PLDN is mutated in the HPS mouse model pallid and encodes the protein pallidin, which interacts with the early endosomal t-SNARE syntaxin-13. We could not detect any full-length pallidin in our patient's cells despite normal mRNA expression of the mutant transcript. We could detect an alternative transcript that would skip the exon that harbored the mutation, but we demonstrate that if this transcript is translated into protein, although it correctly localizes to early endosomes, it does not interact with syntaxin-13. In our patient's melanocytes, the melanogenic protein TYRP1 showed aberrant localization, an increase in plasma-membrane trafficking, and a failure to reach melanosomes, explaining the boy's severe albinism and establishing his diagnosis as HPS-9. JF - American Journal of Human Genetics AU - Cullinane, Andrew R AU - Curry, James A AU - Carmona-Rivera, Carmelo AU - Summers, CGail AU - Ciccone, Carla AU - Cardillo, Nicholas D AU - Dorward, Heidi AU - Hess, Richard A AU - White, James G AU - Adams, David AU - Huizing, Marjan AU - Gahl, William A Y1 - 2011/06/10/ PY - 2011 DA - 2011 Jun 10 SP - 778 EP - 787 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA VL - 88 IS - 6 SN - 0002-9297, 0002-9297 KW - Toxicology Abstracts; Genetics Abstracts KW - Granules KW - Exons KW - Animal models KW - Hermansky-Pudlak syndrome KW - Transcription KW - Melanocytes KW - Nonsense mutation KW - Albinism KW - Gene expression KW - endosomes KW - Bleeding KW - Platelets KW - Vesicles KW - Melanosomes KW - Organelles KW - Evolution KW - X 24310:Pharmaceuticals KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876244281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Human+Genetics&rft.atitle=A+BLOC-1+Mutation+Screen+Reveals+that+PLDN+Is+Mutated+in+Hermansky-Pudlak+Syndrome+Type+9&rft.au=Cullinane%2C+Andrew+R%3BCurry%2C+James+A%3BCarmona-Rivera%2C+Carmelo%3BSummers%2C+CGail%3BCiccone%2C+Carla%3BCardillo%2C+Nicholas+D%3BDorward%2C+Heidi%3BHess%2C+Richard+A%3BWhite%2C+James+G%3BAdams%2C+David%3BHuizing%2C+Marjan%3BGahl%2C+William+A&rft.aulast=Cullinane&rft.aufirst=Andrew&rft.date=2011-06-10&rft.volume=88&rft.issue=6&rft.spage=778&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Human+Genetics&rft.issn=00029297&rft_id=info:doi/10.1016%2Fj.ajhg.2011.05.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-04-06 N1 - SubjectsTermNotLitGenreText - Granules; Exons; Hermansky-Pudlak syndrome; Animal models; Transcription; Melanocytes; Albinism; Nonsense mutation; Gene expression; endosomes; Platelets; Bleeding; Melanosomes; Vesicles; Organelles; Evolution DO - http://dx.doi.org/10.1016/j.ajhg.2011.05.009 ER - TY - JOUR T1 - Mutations in FYCO1 Cause Autosomal-Recessive Congenital Cataracts AN - 876244273; 15113840 AB - Congenital cataracts (CCs), responsible for about one-third of blindness in infants, are a major cause of vision loss in children worldwide. Autosomal-recessive congenital cataracts (arCC) form a clinically diverse and genetically heterogeneous group of disorders of the crystalline lens. To identify the genetic cause of arCC in consanguineous Pakistani families, we performed genome-wide linkage analysis and fine mapping and identified linkage to 3p21-p22 with a summed LOD score of 33.42. Mutations in the gene encoding FYVE and coiled-coil domain containing 1 (FYCO1), a PI(3)P-binding protein family member that is associated with the exterior of autophagosomes and mediates microtubule plus-end-directed vesicle transport, were identified in 12 Pakistani families and one Arab Israeli family in which arCC had previously been mapped to the overlapping CATC2 region. Nine different mutations were identified, including c.3755 delC (p.Ala1252AspfsX71), c.3858_3862dupGGAAT (p.Leu1288TrpfsX37), c.1045 CT (p.Gln349X), c.2206CT (p.Gln736X), c.2761CT (p.Arg921X), c.2830CT (p.Arg944X), c.3150+1 GT, c.4127TC (p.Leu1376Pro), and c.1546CT (p.Gln516X). Fyco1 is expressed in the mouse embryonic and adult lens and peaks at P12d. Expressed mutant proteins p.Leu1288TrpfsX37 and p.Gln736X are truncated on immunoblots. Wild-type and p.L1376P FYCO1, the only missense mutant identified, migrate at the expected molecular mass. Both wild-type and p. Leu1376Pro FYCO1 proteins expressed in human lens epithelial cells partially colocalize to microtubules and are found adjacent to Golgi, but they primarily colocalize to autophagosomes. Thus, FYCO1 is involved in lens development and transparency in humans, and mutations in this gene are one of the most common causes of arCC in the Pakistani population. JF - American Journal of Human Genetics AU - Chen, Jianjun AU - Ma, Zhiwei AU - Jiao, Xiaodong AU - Fariss, Robert AU - Kantorow, Wanda Lee AU - Kantorow, Marc AU - Pras, Eran AU - Frydman, Moshe AU - Pras, Elon AU - Riazuddin, Sheikh AU - Riazuddin, SAmer AU - Hejtmancik, JFielding Y1 - 2011/06/10/ PY - 2011 DA - 2011 Jun 10 SP - 827 EP - 838 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA VL - 88 IS - 6 SN - 0002-9297, 0002-9297 KW - Toxicology Abstracts; Genetics Abstracts KW - Golgi apparatus KW - Epithelial cells KW - Microtubules KW - Cataracts KW - Phagosomes KW - protein families KW - Blindness KW - Missense mutant KW - Children KW - Linkage analysis KW - Vision KW - Embryos KW - Vesicles KW - Cell migration KW - Mutation KW - Gene mapping KW - Infants KW - G 07730:Development & Cell Cycle KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876244273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Human+Genetics&rft.atitle=Mutations+in+FYCO1+Cause+Autosomal-Recessive+Congenital+Cataracts&rft.au=Chen%2C+Jianjun%3BMa%2C+Zhiwei%3BJiao%2C+Xiaodong%3BFariss%2C+Robert%3BKantorow%2C+Wanda+Lee%3BKantorow%2C+Marc%3BPras%2C+Eran%3BFrydman%2C+Moshe%3BPras%2C+Elon%3BRiazuddin%2C+Sheikh%3BRiazuddin%2C+SAmer%3BHejtmancik%2C+JFielding&rft.aulast=Chen&rft.aufirst=Jianjun&rft.date=2011-06-10&rft.volume=88&rft.issue=6&rft.spage=827&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Human+Genetics&rft.issn=00029297&rft_id=info:doi/10.1016%2Fj.ajhg.2011.05.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-04-06 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Golgi apparatus; Microtubules; Cataracts; Phagosomes; protein families; Blindness; Children; Missense mutant; Linkage analysis; Vision; Vesicles; Embryos; Cell migration; Mutation; Infants; Gene mapping DO - http://dx.doi.org/10.1016/j.ajhg.2011.05.008 ER - TY - JOUR T1 - Solution structure of the monovalent lectin microvirin in complex with Man(alpha)(1-2)Man provides a basis for anti-HIV activity with low toxicity. AN - 870547327; 21471192 AB - Lectins that bind surface envelope glycoprotein gp120 of HIV with high avidity can potently inhibit viral entry. Yet properties such as multivalency that facilitate strong interactions can also cause nonspecific binding and toxicity. The cyanobacterial lectin microvirin (MVN) is unusual as it potently inhibits HIV-1 with negligible toxicity compared with cyanovirin-N (CVN), its well studied antiviral homolog. To understand the structural and mechanistic basis for these differences, we solved the solution structure of MVN free and in complex with its ligand Manα(1-2)Man, and we compared specificity and time windows of inhibition with CVN and Manα(1-2)Man-specific mAb 2G12. We show by NMR and analytical ultracentrifugation that MVN is monomeric in solution, and we demonstrate by NMR that Manα(1-2)Man-terminating carbohydrates interact with a single carbohydrate-binding site. Synchronized infectivity assays show that 2G12, MVN, and CVN inhibit entry with distinct kinetics. Despite shared specificity for Manα(1-2)Man termini, combinations of the inhibitors are synergistic suggesting they recognize discrete glycans and/or dynamic glycan conformations on gp120. Entry assays employing amphotropic viruses show that MVN is inactive, whereas CVN potently inhibits both. In addition to demonstrating that HIV-1 can be inhibited through monovalent interactions, given the similarity of the carbohydrate-binding site common to MVN and CVN, these data suggest that gp120 behaves as a clustered glycan epitope and that multivalent-protein interactions achievable with CVN but not MVN are required for inhibition of some viruses. JF - The Journal of biological chemistry AU - Shahzad-ul-Hussan, Syed AU - Gustchina, Elena AU - Ghirlando, Rodolfo AU - Clore, G Marius AU - Bewley, Carole A AD - Laboratory of Bioorganic Chemistry, NIDDK,National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2011/06/10/ PY - 2011 DA - 2011 Jun 10 SP - 20788 EP - 20796 VL - 286 IS - 23 KW - Anti-HIV Agents KW - 0 KW - Bacterial Proteins KW - HIV Envelope Protein gp120 KW - Mannose-Binding Lectin KW - gp120 protein, Human immunodeficiency virus 1 KW - microvirin protein, Microcystis aeruginosa KW - Disaccharidases KW - EC 3.2.1.- KW - Mannose KW - PHA4727WTP KW - Index Medicus KW - Nuclear Magnetic Resonance, Biomolecular -- methods KW - Humans KW - HEK293 Cells KW - HIV Infections -- drug therapy KW - HIV Infections -- metabolism KW - Binding Sites KW - Anti-HIV Agents -- chemistry KW - HIV-1 -- metabolism KW - HIV-1 -- chemistry KW - Bacterial Proteins -- chemistry KW - Disaccharidases -- chemistry KW - Anti-HIV Agents -- pharmacology KW - HIV Envelope Protein gp120 -- chemistry KW - Mannose -- chemistry KW - Mannose-Binding Lectin -- chemistry KW - HIV Envelope Protein gp120 -- metabolism KW - HIV Envelope Protein gp120 -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/870547327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Solution+structure+of+the+monovalent+lectin+microvirin+in+complex+with+Man%28alpha%29%281-2%29Man+provides+a+basis+for+anti-HIV+activity+with+low+toxicity.&rft.au=Shahzad-ul-Hussan%2C+Syed%3BGustchina%2C+Elena%3BGhirlando%2C+Rodolfo%3BClore%2C+G+Marius%3BBewley%2C+Carole+A&rft.aulast=Shahzad-ul-Hussan&rft.aufirst=Syed&rft.date=2011-06-10&rft.volume=286&rft.issue=23&rft.spage=20788&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M111.232678 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-05 N1 - Date created - 2011-06-06 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 2Y1S; PDB N1 - SuppNotes - Cited By: Science. 2003 Jun 27;300(5628):2065-71 [12829775] Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16249-54 [12444251] AIDS Res Hum Retroviruses. 2004 Jan;20(1):11-8 [15000694] Carbohydr Res. 2004 Apr 2;339(5):967-73 [15010304] J Mol Biol. 2004 Jun 11;339(4):901-14 [15165858] Biochemistry. 2004 Jun 29;43(25):8230-3 [15209519] Glycobiology. 2004 Nov;14(11):53R-62R [15229195] J Mol Biol. 1979 Apr 5;129(2):235-64 [225498] Eur J Biochem. 1981 Mar 16;115(1):207-16 [7227366] J Biol Chem. 1982 Apr 25;257(8):4023-6 [7068621] J Gen Virol. 1982 Jan;58 Pt 1:13-23 [6292339] Biochemistry. 1989 Nov 14;28(23):8972-9 [2690953] J Biol Chem. 1990 May 25;265(15):8519-24 [2341393] J Biol Chem. 2006 Sep 1;281(35):25177-83 [16809348] J Mol Biol. 2006 Dec 1;364(3):283-9 [17010381] Nature. 2007 Apr 26;446(7139):1038-45 [17460665] J Biomol NMR. 2009 Aug;44(4):213-23 [19548092] J Biol Chem. 1990 Jun 25;265(18):10373-82 [2355006] Biochemistry. 1990 Aug 14;29(32):7387-401 [2223770] Biochemistry. 1993 Oct 19;32(41):11087-99 [8218172] J Biomol NMR. 1995 Nov;6(3):277-93 [8520220] Chem Biol. 1996 Feb;3(2):71-7 [8807830] J Magn Reson. 1998 Apr;131(2):373-8 [9571116] Cell. 1998 May 29;93(5):681-4 [9630213] J Magn Reson. 1998 Jul;133(1):216-21 [9654491] Nat Struct Biol. 1998 Jul;5(7):571-8 [9665171] Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15613-7 [9861018] Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17033-8 [15563589] J Biol Chem. 2005 Mar 11;280(10):9345-53 [15613479] J Virol. 2005 Aug;79(16):10108-25 [16051804] Proteins. 2005 Sep 1;60(4):670-8 [16003744] Mol Microbiol. 2006 Feb;59(3):893-906 [16420359] Antiviral Res. 2009 Oct;84(1):67-75 [19665490] Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15633-8 [19717426] J Am Chem Soc. 2009 Nov 18;131(45):16500-8 [19856962] Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7722-7 [20382864] J Antimicrob Chemother. 2010 Jun;65(6):1100-7 [20348088] JAMA. 2010 Jul 21;304(3):350-1 [20639573] J Biol Chem. 2010 Aug 6;285(32):24845-54 [20507987] Nat Rev Microbiol. 2007 Aug;5(8):583-97 [17632570] Methods Cell Biol. 2008;84:143-79 [17964931] J Virol. 2007 Dec;81(23):12946-53 [17898046] Biochemistry. 2008 Aug 19;47(33):8470-6 [18652478] Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6099-104 [19332801] Biochemistry. 2009 May 12;48(18):3822-7 [19292456] Nature. 2000 Feb 10;403(6770):669-72 [10688205] Biophys J. 2000 Mar;78(3):1606-19 [10692345] J Virol. 2000 Nov;74(21):10074-80 [11024136] J Am Chem Soc. 2001 May 2;123(17):3892-902 [11457139] J Magn Reson. 2001 Oct;152(2):288-302 [11567582] Structure. 2001 Oct;9(10):931-40 [11591348] J Mol Biol. 2002 Sep 27;322(4):881-9 [12270721] Curr Opin Struct Biol. 2002 Oct;12(5):616-23 [12464313] Antimicrob Agents Chemother. 2003 Aug;47(8):2518-25 [12878514] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M111.232678 ER - TY - JOUR T1 - Topics in machine learning for biomedical literature analysis and text retrieval AN - 883026329; 15090110 JF - BMC Bioinformatics AU - Islamaj Dogan, Rezarta AU - Yeganova, Lana AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2011/06/09/ PY - 2011 DA - 2011 Jun 09 SP - I1 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 12 IS - 3 KW - Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883026329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Topics+in+machine+learning+for+biomedical+literature+analysis+and+text+retrieval&rft.au=Islamaj+Dogan%2C+Rezarta%3BYeganova%2C+Lana&rft.aulast=Islamaj+Dogan&rft.aufirst=Rezarta&rft.date=2011-06-09&rft.volume=12&rft.issue=3&rft.spage=I1&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-12-S3-I1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 DO - http://dx.doi.org/10.1186/1471-2105-12-S3-I1 ER - TY - JOUR T1 - A context-blocks model for identifying clinical relationships in patient records AN - 883025863; 15090112 AB - Patient records contain valuable information regarding explanation of diagnosis, progression of disease, prescription and/or effectiveness of treatment, and more. Automatic recognition of clinically important concepts and the identification of relationships between those concepts in patient records are preliminary steps for many important applications in medical informatics, ranging from quality of care to hypothesis generation. In this work we describe an approach that facilitates the automatic recognition of eight relationships defined between medical problems, treatments and tests. Unlike the traditional bag-of-words representation, in this work, we represent a relationship with a scheme of five distinct context-blocks determined by the position of concepts in the text. As a preliminary step to relationship recognition, and in order to provide an end-to-end system, we also addressed the automatic extraction of medical problems, treatments and tests. Our approach combined the outcome of a statistical model for concept recognition and simple natural language processing features in a conditional random fields model. A set of 826 patient records from the 4th i2b2 challenge was used for training and evaluating the system. Results show that our concept recognition system achieved an F-measure of 0.870 for exact span concept detection. Moreover the context-block representation of relationships was more successful (F-Measure = 0.775) at identifying relationships than bag-of-words (F-Measure = 0.402). Most importantly, the performance of the end-to-end system of relationship extraction using automatically extracted concepts (F-Measure = 0.704) was comparable to that obtained using manually annotated concepts (F-Measure = 0.711), and their difference was not statistically significant. We extracted important clinical relationships from text in an automated manner, starting with concept recognition, and ending with relationship identification. The advantage of the context-blocks representation scheme was the correct management of word position information, which may be critical in identifying certain relationships. Our results may serve as benchmark for comparison to other systems developed on i2b2 challenge data. Finally, our system may serve as a preliminary step for other discovery tasks in medical informatics. JF - BMC Bioinformatics AU - Islamaj Dogan, Rezarta AU - Neveol, Aurelie AU - Lu, Zhiyong AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2011/06/09/ PY - 2011 DA - 2011 Jun 09 SP - S3 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 12 IS - 3 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Mathematical models KW - Informatics KW - Statistical analysis KW - Language KW - Bioinformatics KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883025863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=A+context-blocks+model+for+identifying+clinical+relationships+in+patient+records&rft.au=Islamaj+Dogan%2C+Rezarta%3BNeveol%2C+Aurelie%3BLu%2C+Zhiyong&rft.aulast=Islamaj+Dogan&rft.aufirst=Rezarta&rft.date=2011-06-09&rft.volume=12&rft.issue=3&rft.spage=S3&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-12-S3-S3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mathematical models; Data processing; Informatics; Statistical analysis; Language; Bioinformatics; Models DO - http://dx.doi.org/10.1186/1471-2105-12-S3-S3 ER - TY - JOUR T1 - Stage-specific proteomic expression patterns of the human filarial parasite Brugia malayi and its endosymbiont Wolbachia AN - 907164851; 14988591 AB - Global proteomic analyses of pathogens have thus far been limited to unicellular organisms (e.g., protozoa and bacteria). Proteomic analyses of most eukaryotic pathogens (e.g., helminths) have been restricted to specific organs, specific stages, or secretomes. We report here a large-scale proteomic characterization of almost all the major mammalian stages of Brugia malayi, a causative agent of lymphatic filariasis, resulting in the identification of more than 62% of the products predicted from the Bm draft genome. The analysis also yielded much of the proteome of Wolbachia, the obligate endosymbiont of Bm that also expressed proteins in a stage-specific manner. Of the 11,610 predicted Bm gene products, 7,103 were definitively identified from adult male, adult female, blood-borne and uterine microfilariae, and infective L3 larvae. Among the 4,956 gene products (42.5%) inferred from the genome as "hypothetical," the present study was able to confirm 2,336 (47.1%) as bona fide proteins. Analysis of protein families and domains coupled with stage-specific expression highlight the important pathways that benefit the parasite during its development in the host. Gene set enrichment analysis identified extracellular matrix proteins and those with immunologic effects as enriched in the microfilarial and L3 stages. Parasite sex- and stage-specific protein expression identified those pathways related to parasite differentiation and demonstrates stage-specific expression by the Bm endosymbiont Wolbachia as well. JF - Proceedings of the National Academy of Sciences, USA AU - Bennuru, Sasisekhar AU - Meng, Zhaojing AU - Ribeiro, Jose MC AU - Semnani, Roshanak Tolouei AU - Ghedin, Elodie AU - Chan, King AU - Lucas, David A AU - Veenstra, Timothy D AU - Nutman, Thomas B AD - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 Y1 - 2011/06/07/ PY - 2011 DA - 2011 Jun 07 SP - 9649 EP - 9654 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 108 IS - 23 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology KW - Bm gene KW - Genomes KW - Parasites KW - Uterus KW - Endosymbionts KW - Wolbachia KW - Larvae KW - Filariasis KW - protein families KW - Gene products KW - Pathogens KW - Hosts KW - Larval development KW - Differentiation KW - Protozoa KW - Brugia malayi KW - secretome KW - Extracellular matrix KW - proteomics KW - O 1070:Ecology/Community Studies KW - K 03490:Miscellaneous KW - Q1 08484:Species interactions: parasites and diseases KW - J 02430:Symbiosis, Antibiosis & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907164851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Stage-specific+proteomic+expression+patterns+of+the+human+filarial+parasite+Brugia+malayi+and+its+endosymbiont+Wolbachia&rft.au=Bennuru%2C+Sasisekhar%3BMeng%2C+Zhaojing%3BRibeiro%2C+Jose+MC%3BSemnani%2C+Roshanak+Tolouei%3BGhedin%2C+Elodie%3BChan%2C+King%3BLucas%2C+David+A%3BVeenstra%2C+Timothy+D%3BNutman%2C+Thomas+B&rft.aulast=Bennuru&rft.aufirst=Sasisekhar&rft.date=2011-06-07&rft.volume=108&rft.issue=23&rft.spage=9649&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Genomes; Parasites; Gene products; Hosts; Pathogens; Larval development; Bm gene; Uterus; Endosymbionts; Filariasis; Larvae; protein families; Differentiation; Protozoa; Extracellular matrix; secretome; proteomics; Wolbachia; Brugia malayi ER - TY - JOUR T1 - Herbal Tonic Does Not Inhibit Estrogen Receptor Negative Mammary Tumor Development in a Transgenic Mouse Model AN - 887493472; 201115450 AB - Women who are diagnosed with breast cancer often self-administer complementary and alternative medicines to augment their conventional treatments, improve health, or prevent recurrence. Flor-Essence herbal tonic is a complex mixture of eight herbal extracts used by cancer patients because of anecdotal evidence that it can treat or prevent disease. In this study four experimental groups of female MMTV-Neu mice were left untreated or treated with 3% Flor-Essence in utero, from birth until 5 weeks of age, or throughout their lifetime. Palpable mammary tumor incidence and body weight was determined weekly for each group. The mice were sacrificed at 28 weeks of age and mammary tumors were enumerated to determine average tumor incidence and multiplicity for each group. Female mice exposed to Flor-Essence herbal tonic in utero weighed significantly more than the control group (p 0.001). The average tumor incidence and tumor multiplicity in the experimental mice treated with Flor-Essence herbal tonic did not differ from the control animals. Flor-Essence does not inhibit mammary tumor incidence or mammary tumor multiplicity in MMTV-Neu transgenic mice. Flor-Essence exposure in utero causes increased body weight in experimental animals. This conclusion challenges widely available anecdotal information as well as the hopes of the consumer that this product will inhibit or suppress tumor development. Adapted from the source document. JF - Journal of Complementary & Integrative Medicine AU - Bennett, L AU - Montgomery, Jennifer AU - Collins, N AU - Steinberg, Seth AU - Kulp, Kristen AD - CCR, NCI, NIH Y1 - 2011/06/07/ PY - 2011 DA - 2011 Jun 07 SP - 1157 PB - Berkeley Electronic Press, CA VL - 8 IS - 1 SN - 2194-6329, 2194-6329 KW - complementary and alternative medicine MMTV-Neu herbal tonic mammary tumors transgenic mouse dietary supplement Essiac KW - Animals KW - Body weight KW - Women KW - Breast cancer KW - Alternative medicine KW - Tumours KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/887493472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Complementary+%26+Integrative+Medicine&rft.atitle=Herbal+Tonic+Does+Not+Inhibit+Estrogen+Receptor+Negative+Mammary+Tumor+Development+in+a+Transgenic+Mouse+Model&rft.au=Bennett%2C+L%3BMontgomery%2C+Jennifer%3BCollins%2C+N%3BSteinberg%2C+Seth%3BKulp%2C+Kristen&rft.aulast=Bennett&rft.aufirst=L&rft.date=2011-06-07&rft.volume=8&rft.issue=1&rft.spage=1157&rft.isbn=&rft.btitle=&rft.title=Journal+of+Complementary+%26+Integrative+Medicine&rft.issn=21946329&rft_id=info:doi/ L2 - http://www.bepress.com/jcim/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Tumours; Animals; Body weight; Women; Alternative medicine; Breast cancer ER - TY - JOUR T1 - Mutant lipooligosaccharide-based conjugate vaccine demonstrates a broad-spectrum effectiveness against Moraxella catarrhalis AN - 874192737; 14963602 AB - There is no licensed vaccine available against Moraxella catarrhalis, an exclusive human pathogen responsible for otitis media in children and respiratory infections in adults. We previously developed conjugate vaccine candidates based on lipooligosaccharides (LOSs) of M. catarrhalis serotypes A, B, and C, each of which was shown to cover a portion of the clinical strains. To generate conserved LOS antigens and eliminate a potential autoimmune response to a similar epitope between M. catarrhalis LOS moiety Gal alpha 1-4Gal beta 1-4Glc and human P[super]k antigen, two LOS mutants from strain O35E were constructed. Mutant O35Elgt5 or O35EgalE revealed a deletion of one or two terminal galactose residues of wild type O35E LOS. Each LOS molecule was purified, characterized, detoxified, and coupled to tetanus toxoid (TT) to form conjugates, namely dLOS-TT. Three subcutaneous immunizations using dLOS-TT from O35Elgt5 or O35EgalE elicited significant increases (a 729- or 1263-fold above the preimmune serum levels) of serum immunoglobulin (Ig)G against O35E LOS in rabbits with an adjuvant or without an adjuvant (an 140- or 140-fold above the preimmune serum levels). Rabbit antisera demonstrated elevated complement-mediated bactericidal activities against the wild type strain O35E. The rabbit sera elicited by O35Elgt5 dLOS-TT were further examined and showed cross bactericidal activity against all additional 19 M. catarrhalis strains and clinical isolates studied. Moreover, the rabbit sera displayed cross-reactivity not only among three serotype strains but also clinical isolates in a whole-cell enzyme-linked immunosorbent assay (ELISA), which was further confirmed under transmission electron microscopy. In conclusion, O35Elgt5 dLOS-TT may act as a vaccine against most M. catarrhalis strains and therefore can be used for further in vivo efficacy studies. JF - Vaccine AU - Ren, Dabin AU - Yu, Shengqing AU - Gao, Song AU - Peng, Daxin AU - Petralia, Ronald S AU - Muszynski, Artur AU - Carlson, Russell W AU - Robbins, John B AU - Tsai, Chao-Ming AU - Lim, David J AU - Gu, Xin-Xing AD - Vaccine Research Section, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health (NIH), 5 Research Court, Rockville, MD 20850, United States, guxx@mail.nih.gov guxx@mail.nih.gov Y1 - 2011/06/06/ PY - 2011 DA - 2011 Jun 06 SP - 4210 EP - 4217 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 29 IS - 25 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Clinical isolates KW - Galactose KW - Enzyme-linked immunosorbent assay KW - Serotypes KW - Cross-reactivity KW - Transmission electron microscopy KW - Complement KW - Moraxella catarrhalis KW - Adjuvants KW - Pathogens KW - Children KW - Infection KW - Tetanus KW - Immunization KW - Lipooligosaccharides KW - Serum levels KW - Antisera KW - Otitis media KW - Vaccines KW - Bactericidal activity KW - Epitopes KW - Immunoglobulins KW - F 06905:Vaccines KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874192737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Mutant+lipooligosaccharide-based+conjugate+vaccine+demonstrates+a+broad-spectrum+effectiveness+against+Moraxella+catarrhalis&rft.au=Ren%2C+Dabin%3BYu%2C+Shengqing%3BGao%2C+Song%3BPeng%2C+Daxin%3BPetralia%2C+Ronald+S%3BMuszynski%2C+Artur%3BCarlson%2C+Russell+W%3BRobbins%2C+John+B%3BTsai%2C+Chao-Ming%3BLim%2C+David+J%3BGu%2C+Xin-Xing&rft.aulast=Ren&rft.aufirst=Dabin&rft.date=2011-06-06&rft.volume=29&rft.issue=25&rft.spage=4210&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2011.03.102 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Galactose; Clinical isolates; Enzyme-linked immunosorbent assay; Cross-reactivity; Serotypes; Transmission electron microscopy; Complement; Pathogens; Adjuvants; Tetanus; Infection; Children; Immunization; Lipooligosaccharides; Serum levels; Antisera; Otitis media; Vaccines; Bactericidal activity; Epitopes; Immunoglobulins; Moraxella catarrhalis DO - http://dx.doi.org/10.1016/j.vaccine.2011.03.102 ER - TY - JOUR T1 - Variation in base excision repair capacity. AN - 868627296; 21167187 AB - The major DNA repair pathway for coping with spontaneous forms of DNA damage, such as natural hydrolytic products or oxidative lesions, is base excision repair (BER). In particular, BER processes mutagenic and cytotoxic DNA lesions such as non-bulky base modifications, abasic sites, and a range of chemically distinct single-strand breaks. Defects in BER have been linked to cancer predisposition, neurodegenerative disorders, and immunodeficiency. Recent data indicate a large degree of sequence variability in DNA repair genes and several studies have associated BER gene polymorphisms with disease risk, including cancer of several sites. The intent of this review is to describe the range of BER capacity among individuals and the functional consequences of BER genetic variants. We also discuss studies that associate BER deficiency with disease risk and the current state of BER capacity measurement assays. Published by Elsevier B.V. JF - Mutation research AU - Wilson, David M AU - Kim, Daemyung AU - Berquist, Brian R AU - Sigurdson, Alice J AD - Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, United States. wilsonda@mail.nih.gov Y1 - 2011/06/03/ PY - 2011 DA - 2011 Jun 03 SP - 100 EP - 112 VL - 711 IS - 1-2 SN - 0027-5107, 0027-5107 KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Index Medicus KW - DNA Repair Enzymes -- metabolism KW - Polymorphism, Genetic KW - Humans KW - Genetic Predisposition to Disease KW - DNA Breaks, Single-Stranded KW - DNA Repair -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/868627296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Variation+in+base+excision+repair+capacity.&rft.au=Wilson%2C+David+M%3BKim%2C+Daemyung%3BBerquist%2C+Brian+R%3BSigurdson%2C+Alice+J&rft.aulast=Wilson&rft.aufirst=David&rft.date=2011-06-03&rft.volume=711&rft.issue=1-2&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/10.1016%2Fj.mrfmmm.2010.12.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-09 N1 - Date created - 2011-05-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1999 Aug 20;274(34):24187-94 [10446193] Nucleic Acids Res. 1999 Oct 15;27(20):4001-7 [10497264] Science. 1999 Oct 15;286(5439):552-5 [10521354] Carcinogenesis. 2004 Dec;25(12):2311-7 [15319300] Mol Carcinog. 2005 Mar;42(3):127-41 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[16446448] DNA Repair (Amst). 2007 Jan 4;6(1):8-18 [16978929] DNA Repair (Amst). 2007 Jan 4;6(1):45-60 [16982217] Cancer Res. 2007 Jan 1;67(1):26-31 [17210680] Curr Biol. 2007 Jan 23;17(2):R55-8 [17240329] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mrfmmm.2010.12.004 ER - TY - JOUR T1 - Dysferlinopathy: Spectrum of pathological changes in skeletal muscle tissue AN - 926899492; 16373263 AB - Background: Dysferlinopathy is an autosomal recessive-limb girdle muscular dystrophy (AR-LGMD) caused due to the defect in gene encoding dysferlin, a sarcolemmal protein. Awareness of the variants and their relative frequency is essential for accurate diagnosis. Aim: To study the spectrum of morphologic changes in immunohistochemically proven cases of dysferlinopathies, to correlate the findings with clinical phenotype and durations of illness and determine the frequency. Materials and Methods: Dysferlinopathies seen over a period of 2 years at a tertiary neurological center were analyzed. Results: Clinically, majority had Miyoshi phenotype (46.6%) with distal involvement and LGMD phenotype (40%) with proximal muscle involvement. In addition, a proximo-distal and tibial muscle phenotype was encountered. Morphologically, rimmed vacuoles were noted in the Miyoshi phenotype. The presence of ragged red fibers, lobulated fibers and inflammation had no preference to a particular phenotype. Significant atrophy and lobulated fibers were noted in patients with longer duration of illness. Conclusions: Dysferlinopathy was the second most common identifiable cause (21%) of LGMD next to sarcoglycanopathies (27%). JF - Indian Journal of Pathology and Microbiology AU - Gayathri, N AU - Alefia, R AU - Nalini, A AU - Yasha, T C AU - Anita, M AU - Santosh, V AU - Shankar, S K AD - Department of Neuropathology, National Institute of Mental Health & Neurosciences, Bangalore - 560 029, Karnataka, India Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 350 EP - 354 VL - 54 IS - 2 SN - 0377-4929, 0377-4929 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - sarcoglycanopathy KW - Vacuoles KW - Skeletal muscle KW - Atrophy KW - Muscular dystrophy KW - Inflammation KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926899492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+Journal+of+Pathology+and+Microbiology&rft.atitle=Dysferlinopathy%3A+Spectrum+of+pathological+changes+in+skeletal+muscle+tissue&rft.au=Gayathri%2C+N%3BAlefia%2C+R%3BNalini%2C+A%3BYasha%2C+T+C%3BAnita%2C+M%3BSantosh%2C+V%3BShankar%2C+S+K&rft.aulast=Gayathri&rft.aufirst=N&rft.date=2011-06-01&rft.volume=54&rft.issue=2&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=Indian+Journal+of+Pathology+and+Microbiology&rft.issn=03774929&rft_id=info:doi/10.4103%2F0377-4929.81636 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - sarcoglycanopathy; Vacuoles; Atrophy; Skeletal muscle; Muscular dystrophy; Inflammation DO - http://dx.doi.org/10.4103/0377-4929.81636 ER - TY - JOUR T1 - Chimeric Tick-Borne Encephalitis/Dengue Virus Is Attenuated in Ixodes scapularis Ticks and Aedes aegypti Mosquitoes AN - 920796786; 16154954 AB - In an effort to derive an efficacious live attenuated vaccine against tick-borne encephalitis, we generated a chimeric virus bearing the structural protein genes of a Far Eastern subtype of tick-borne encephalitis virus (TBEV) on the genetic background of recombinant dengue 4 (DEN4) virus. Introduction of attenuating mutations into the TBEV envelope protein gene, as well as the DEN4 NS5 protein gene and 3' noncoding region in the chimeric genome, results in decreased neurovirulence and neuroinvasiveness in mice, and restricted replication in mouse brain. Since TBEV and DEN4 viruses are transmitted in nature by ticks and mosquitoes, respectively, it was of interest to investigate the infectivity of the chimeric virus for both arthropod vectors. Therefore, parental and chimeric viruses were tested for growth in mosquito and tick cells and for oral infection in vivo. Although all chimeric viruses demonstrated moderate levels of replication in C6/36 mosquito cells, they were unable to replicate in ISE6 tick cells. Further, the chimeric viruses were unable to infect or replicate in Aedes aegypti mosquitoes and Ixodes scapularis tick larvae. The poor infectivity for both potential vectors reinforces the safety of chimeric virus-based vaccine candidates for the environment and for use in humans. JF - Vector Borne and Zoonotic Diseases AU - Engel, A R AU - Mitzel, D N AU - Hanson, C T AU - Wolfinbarger, J B AU - Bloom, ME AU - Pletnev, A G AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 33, Room 3W10A, 33 North Drive, MSC 3203 Bethesda, MD 20892, USA, apletnev@niaid.nih.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 665 EP - 674 VL - 11 IS - 6 SN - 1530-3667, 1530-3667 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Entomology Abstracts; CSA Neurosciences Abstracts; Virology & AIDS Abstracts KW - Dengue virus KW - Genomes KW - Aedes aegypti KW - Invasiveness KW - Human diseases KW - Viruses KW - Disease control KW - Ixodes scapularis KW - Hosts KW - Structural proteins KW - Public health KW - Disease transmission KW - Tick-borne encephalitis KW - Envelope protein KW - Tick-borne encephalitis virus KW - Aquatic insects KW - Replication KW - Ixodidae KW - Neurovirulence KW - Brain KW - Vectors KW - Infectivity KW - Arthropoda KW - NS5 protein KW - Vaccines KW - Oral infection KW - Mutation KW - N3 11023:Neurogenetics KW - Q1 08484:Species interactions: parasites and diseases KW - Z 05360:Genetics and Evolution KW - V 22320:Replication KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920796786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vector+Borne+and+Zoonotic+Diseases&rft.atitle=Chimeric+Tick-Borne+Encephalitis%2FDengue+Virus+Is+Attenuated+in+Ixodes+scapularis+Ticks+and+Aedes+aegypti+Mosquitoes&rft.au=Engel%2C+A+R%3BMitzel%2C+D+N%3BHanson%2C+C+T%3BWolfinbarger%2C+J+B%3BBloom%2C+ME%3BPletnev%2C+A+G&rft.aulast=Engel&rft.aufirst=A&rft.date=2011-06-01&rft.volume=11&rft.issue=6&rft.spage=665&rft.isbn=&rft.btitle=&rft.title=Vector+Borne+and+Zoonotic+Diseases&rft.issn=15303667&rft_id=info:doi/10.1089%2Fvbz.2010.0179 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Human diseases; Replication; Viruses; Disease control; Vaccines; Hosts; Aquatic insects; Disease transmission; Public health; Genomes; Invasiveness; Brain; Neurovirulence; Vectors; Structural proteins; Tick-borne encephalitis; Infectivity; Envelope protein; NS5 protein; Oral infection; Mutation; Dengue virus; Aedes aegypti; Arthropoda; Ixodidae; Ixodes scapularis; Tick-borne encephalitis virus DO - http://dx.doi.org/10.1089/vbz.2010.0179 ER - TY - JOUR T1 - Skin microbiome: genomics-based insights into the diversity and role of skin microbes AN - 907163340; 15113127 AB - Recent advances in DNA sequencing methodology have facilitated studies of human skin microbes that circumvent difficulties in isolating and characterizing fastidious microbes. Sequence-based approaches have identified a greater diversity of cutaneous bacteria than studies using traditional cultivation techniques. However, improved sequencing technologies and analytical methods are needed to study all skin microbes, including bacteria, archaea, fungi, viruses and mites, and how they interact with each other and their human hosts. This review discusses current skin microbiome research, with a primary focus on bacteria, and the challenges facing investigators striving to understand how skin microorganisms contribute to health and disease. JF - Trends in Molecular Medicine AU - Kong, Heidi H AD - Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, 10 Center Drive, Bldg 10, Rm 12N238, Bethesda, MD 20892, USA, konghe@mail.nih.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 320 EP - 328 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 17 IS - 6 SN - 1471-4914, 1471-4914 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Cultivation techniques KW - DNA sequencing KW - Fungi KW - Microorganisms KW - Reviews KW - Skin KW - Archaea KW - K 03450:Ecology KW - G 07770:Bacteria KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907163340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Molecular+Medicine&rft.atitle=Skin+microbiome%3A+genomics-based+insights+into+the+diversity+and+role+of+skin+microbes&rft.au=Kong%2C+Heidi+H&rft.aulast=Kong&rft.aufirst=Heidi&rft.date=2011-06-01&rft.volume=17&rft.issue=6&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Trends+in+Molecular+Medicine&rft.issn=14714914&rft_id=info:doi/10.1016%2Fj.molmed.2011.01.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-09-10 N1 - SubjectsTermNotLitGenreText - DNA sequencing; Skin; Fungi; Reviews; Microorganisms; Cultivation techniques; Archaea DO - http://dx.doi.org/10.1016/j.molmed.2011.01.013 ER - TY - JOUR T1 - A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems AN - 899158203; 15602493 AB - The use of nucleases as toxins for defense, offense or addiction of selfish elements is widely encountered across all life forms. Using sensitive sequence profile analysis methods, we characterize a novel superfamily (the SUKH superfamily) that unites a diverse group of proteins including Smi1/Knr4, PGs2, FBXO3, SKIP16, Syd, herpesviral US22, IRS1 and TRS1, and their bacterial homologs. Using contextual analysis we present evidence that the bacterial members of this superfamily are potential immunity proteins for a variety of toxin systems that also include the recently characterized contact-dependent inhibition (CDI) systems of proteobacteria. By analyzing the toxin proteins encoded in the neighborhood of the SUKH superfamily we predict that they possess domains belonging to diverse nuclease and nucleic acid deaminase families. These include at least eight distinct types of DNases belonging to HNH/EndoVII- and restriction endonuclease-fold, and RNases of the EndoU-like and colicin E3-like cytotoxic RNases-folds. The N-terminal domains of these toxins indicate that they are extruded by several distinct secretory mechanisms such as the two-partner system (shared with the CDI systems) in proteobacteria, ESAT-6/WXG-like ATP-dependent secretory systems in Gram-positive bacteria and the conventional Sec-dependent system in several bacterial lineages. The hedgehog-intein domain might also release a subset of toxic nuclease domains through auto-proteolytic action. Unlike classical colicin-like nuclease toxins, the overwhelming majority of toxin systems with the SUKH superfamily is chromosomally encoded and appears to have diversified through a recombination process combining different C-terminal nuclease domains to N-terminal secretion-related domains. Across the bacterial superkingdom these systems might participate in discriminating `self' or kin from `non-self' or non-kin strains. Using structural analysis we demonstrate that the SUKH domain possesses a versatile scaffold that can be used to bind a wide range of protein partners. In eukaryotes it appears to have been recruited as an adaptor to regulate modification of proteins by ubiquitination or polyglutamylation. Similarly, another widespread immunity protein from these toxin systems, namely the suppressor of fused (SuFu) superfamily has been recruited for comparable roles in eukaryotes. In animal DNA viruses, such as herpesviruses, poxviruses, iridoviruses and adenoviruses, the ability of the SUKH domain to bind diverse targets has been deployed to counter diverse anti-viral responses by interacting with specific host proteins. JF - Nucleic Acids Research AU - Zhang, Dapeng AU - Iyer, Lakshminarayan M AU - Aravind, L Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 4532 EP - 4552 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 39 IS - 11 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Gram-positive bacteria KW - Recruitment KW - Nuclease KW - Self KW - Immunity KW - DNA viruses KW - Proteobacteria KW - scaffolds KW - Toxins KW - ubiquitination KW - Recombination KW - Cytotoxicity KW - nucleic acids KW - Antiviral agents KW - Colicins KW - DNA KW - Addiction KW - Offense KW - ESAT-6 antigen KW - J 02310:Genetics & Taxonomy KW - X 24380:Social Poisons & Drug Abuse KW - V 22320:Replication KW - N 14810:Methods KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899158203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=A+novel+immunity+system+for+bacterial+nucleic+acid+degrading+toxins+and+its+recruitment+in+various+eukaryotic+and+DNA+viral+systems&rft.au=Zhang%2C+Dapeng%3BIyer%2C+Lakshminarayan+M%3BAravind%2C+L&rft.aulast=Zhang&rft.aufirst=Dapeng&rft.date=2011-06-01&rft.volume=39&rft.issue=11&rft.spage=4532&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkr036 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Gram-positive bacteria; Recruitment; Self; Nuclease; Immunity; DNA viruses; Toxins; scaffolds; Recombination; ubiquitination; Cytotoxicity; nucleic acids; Antiviral agents; DNA; Colicins; Addiction; Offense; ESAT-6 antigen; Proteobacteria DO - http://dx.doi.org/10.1093/nar/gkr036 ER - TY - JOUR T1 - Estimating the personal cure rate of cancer patients using population-based grouped cancer survival data AN - 896194268; 201118623 AB - Cancer patients are subject to multiple competing risks of death and may die from causes other than the cancer diagnosed. The probability of not dying from the cancer diagnosed, which is one of the patients' main concerns, is sometimes called the 'personal cure' rate. Two approaches of modelling competing-risk survival data, namely the cause-specific hazards approach and the mixture model approach, have been used to model competing-risk survival data. In this article, we first show the connection and differences between crude cause-specific survival in the presence of other causes and net survival in the absence of other causes. The mixture survival model is extended to population-based grouped survival data to estimate the personal cure rate. Using the colorectal cancer survival data from the Surveillance, Epidemiology and End Results Programme, we estimate the probabilities of dying from colorectal cancer, heart disease, and other causes by age at diagnosis, race and American Joint Committee on Cancer stage. Adapted from the source document. JF - Statistical Methods in Medical Research AU - Yu, Binbing AU - Tiwari, Ram C AU - Feuer, Eric J AD - Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, MD 20892, USA yubi@mail.nih.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 261 EP - 274 PB - Sage Publications, London UK VL - 20 IS - 3 SN - 0962-2802, 0962-2802 KW - Cure KW - Colorectal cancer KW - Mixtures KW - Dying KW - Surveillance KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896194268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Estimating+the+personal+cure+rate+of+cancer+patients+using+population-based+grouped+cancer+survival+data&rft.au=Yu%2C+Binbing%3BTiwari%2C+Ram+C%3BFeuer%2C+Eric+J&rft.aulast=Yu&rft.aufirst=Binbing&rft.date=2011-06-01&rft.volume=20&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280209347046 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Number of references - 17 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Cancer; Cure; Dying; Colorectal cancer; Mixtures; Surveillance DO - http://dx.doi.org/10.1177/0962280209347046 ER - TY - JOUR T1 - Comparative community outreach to increase cervical cancer screening in the Mississippi Delta AN - 896190063; 201116430 AB - The aim of the study was to increase participation in cervical cancer screening of under-screened women living in the Mississippi Delta, a U.S. population at high risk for cervical cancer. Methods: We conducted a door-to-door feasibility study of women living in the Mississippi Delta to increase participation in cervical cancer screening in 2009-10. Women (n = 119) aged 26-65 years who had not been screened in last 3 years or more, were not pregnant, and had a cervix were offered a cost-free choice: clinic-based Pap testing or home self-collection with HPV DNA testing. Results: Seventy-seven women (64.7%) chose self-collection with HPV testing, of which sixty-two (80.5%) returned their self-collected specimen. By comparison, 42 women (35.3%) chose Pap testing, of which 17 (40.5%) attended their clinic appointment. Thus there was an almost 4-fold greater participation of under-screened women in self-collection with HPV testing than in free Pap testing (78.4% vs. 21.5%). Conclusions: We found that offering self-collection will increase participation in cervical cancer screening among under-screened populations living in the Mississippi Delta. Based on these preliminary results, we suggest that self-collection with HPV DNA testing might complement current Pap testing programs to reach under-screened populations of women, such as those living in the Mississippi Delta. [Copyright Elsevier B.V.] JF - Preventive Medicine AU - Castle, Philip E AU - Rausa, Alfio AU - Walls, Tameka AU - Gravitt, Patti E AU - Partridge, Edward E AU - Olivo, Vanessa AU - Niwa, Shelley AU - Morrissey, Kerry Grace AU - Tucker, Laura AU - Katki, Hormuzd AU - Scarinci, Isabel AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA philip.castle@ascp.org Y1 - 2011/06/01/ PY - 2011 DA - 2011 Jun 01 SP - 452 EP - 455 PB - Elsevier Ltd, The Netherlands VL - 52 IS - 6 SN - 0091-7435, 0091-7435 KW - Pap Cervical intraepithelial neoplasia (CIN) Cervical cancer Human papillomavirus (HPV) Atypical squamous cells of undetermined significance (ASC-US) Hybrid Capture 2 (HC2) Health disparities Cervical cancer screening KW - Screening KW - Cervical cancer KW - Women KW - DNA KW - Clinics KW - Human papillomaviruses KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896190063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventive+Medicine&rft.atitle=Comparative+community+outreach+to+increase+cervical+cancer+screening+in+the+Mississippi+Delta&rft.au=Castle%2C+Philip+E%3BRausa%2C+Alfio%3BWalls%2C+Tameka%3BGravitt%2C+Patti+E%3BPartridge%2C+Edward+E%3BOlivo%2C+Vanessa%3BNiwa%2C+Shelley%3BMorrissey%2C+Kerry+Grace%3BTucker%2C+Laura%3BKatki%2C+Hormuzd%3BScarinci%2C+Isabel&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2011-06-01&rft.volume=52&rft.issue=6&rft.spage=452&rft.isbn=&rft.btitle=&rft.title=Preventive+Medicine&rft.issn=00917435&rft_id=info:doi/10.1016%2Fj.ypmed.2011.03.018 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Women; Cervical cancer; Human papillomaviruses; Screening; DNA; Clinics DO - http://dx.doi.org/10.1016/j.ypmed.2011.03.018 ER - TY - JOUR T1 - Willingness of Mexican-American Adults to Share Family Health History with Healthcare Providers AN - 896181737; 201117296 AB - Collecting family health history (FHH) information to share with healthcare providers is an important aspect of health-risk assessment To examine associations between the content of FHH-informed risk feedback and willingness to share the information with a healthcare provider. Methods: Data were collected between June 2008 and July 2009 from 475 Mexican-origin adults residing in 161 households. Participants completed surveys 3 months after receiving FHH-informed risk feedback. Households were randomly assigned to feedback conditions in which household members received one or more of the following: an FHH pedigree, personalized risk assessments (PRAs), and tailored behavioral recommendations. Logistic regression models were fitted using generalized estimating equations, with exchangeable covariances, to account for the clustering of responses within and the random assignment of feedback condition to household. Analyses were completed in May 2010. Results: Participants who received personalized risk assessments were more willing to share their feedback with a provider than those who received a pedigree only (OR=2.25, p=0.02). The receipt of tailored behavioral recommendations did not significantly increase willingness to share feedback with a provider (OR=0.79, p=0.48). Conclusions: The provision of PRAs in FHH assessments appears to motivate participants to consider sharing their FHH with a healthcare provider. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Koehly, Laura M AU - Ashida, Sato AU - Goergen, Andrea F AU - Skapinsky, Kaley F AU - Hadley, Donald W AU - Wilkinson, Anna V AD - Social and Behavioral Research Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland koehlyl@mail.nih.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 633 EP - 636 PB - Elsevier Science, New York NY VL - 40 IS - 6 SN - 0749-3797, 0749-3797 KW - Risk assessment KW - Health care KW - Households KW - Health KW - Feedback KW - Individualized KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896181737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Willingness+of+Mexican-American+Adults+to+Share+Family+Health+History+with+Healthcare+Providers&rft.au=Koehly%2C+Laura+M%3BAshida%2C+Sato%3BGoergen%2C+Andrea+F%3BSkapinsky%2C+Kaley+F%3BHadley%2C+Donald+W%3BWilkinson%2C+Anna+V&rft.aulast=Koehly&rft.aufirst=Laura&rft.date=2011-06-01&rft.volume=40&rft.issue=6&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2011.02.013 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Feedback; Health care; Risk assessment; Households; Health; Individualized DO - http://dx.doi.org/10.1016/j.amepre.2011.02.013 ER - TY - JOUR T1 - Modelling the cumulative risk of a false-positive screening test AN - 896180489; 201116157 AB - Comments on an article, "Modeling the cumulative risk of a false-positive screening test" by Rebecca A. Hubbard, Diana L. Miglioretti, and Robert A. Smith, Statistical Methods in Medical Research 19(5): 429-449. Adapted from the source document. JF - Statistical Methods in Medical Research AU - Baker, Stuart G AD - Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA sb16i@nih.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 291 EP - 293 PB - Sage Publications, London UK VL - 20 IS - 3 SN - 0962-2802, 0962-2802 KW - Screening KW - False positive results KW - Medical research KW - Modelling KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896180489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Modelling+the+cumulative+risk+of+a+false-positive+screening+test&rft.au=Baker%2C+Stuart+G&rft.aulast=Baker&rft.aufirst=Stuart&rft.date=2011-06-01&rft.volume=20&rft.issue=3&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280210392588 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Number of references - 4 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Screening; False positive results; Medical research; Modelling DO - http://dx.doi.org/10.1177/0962280210392588 ER - TY - JOUR T1 - Distress screening in allogeneic hematopoietic stem cell (HSCT) caregivers and patients AN - 896166070; 201116243 AB - Family caregivers of allogeneic hematopoietic stem cell transplant (HSCT) patients are at risk for experiencing significant psychological distress yet screening caregivers has not been well studied. Objective: This analysis explored the psychometric characteristics of the Distress Thermometer (DT) by examining its relationship, sensitivity, and specificity relative to the Brief Symptom Inventory 18 (BSI-18) and the Multidimensional Fatigue Symptom Inventory (MFSI) in a sample of allogeneic HSCT caregivers and patients. Methods: Longitudinal data were drawn from an ongoing intervention study for HSCT caregivers and patients. Data from one hundred and fifty-six English-speaking adults where patients (n = 65) were receiving their first allogeneic HSCT with at least one adult caregiver (n = 91) were eligible for this analysis. Study questionnaires were administered at baseline, initial discharge, and 6 weeks following discharge. Results: Construct validity was supported by significant relationships (p <0.001) between the DT and the BSI-18 GSI and the MFSI-Emotional subscales for caregivers and patients. The diagnostic utility of the DT for patients was good (AUC = 0.85 +/- 0.05, p = 0.001), while for caregivers it was poor (AUC = 0.61 +/- 0.08, p = 0.28). A DT cut point of 5 was supported for patients (sensitivity 1.0, specificity = 0.68), while for caregivers there was less confidence (sensitivity = 0.70, specificity 0.52). Caregivers and patients reporting a higher number of problems had a greater level of distress (p <0.001). Conclusions: These findings support the validity of the DT in screening for distress in HSCT caregivers and patients. Although the diagnostic utility of the DT for HSCT caregivers may be limited, understanding factors associated with distress can guide practice for this understudied population. [Copyright John Wiley and Sons, Ltd.] JF - Psycho-Oncology AU - Bevans, Margaret AU - Wehrlen, Leslie AU - Prachenko, Olena AU - Soeken, Karen AU - Zabora, James AU - Wallen, Gwenyth R AD - 5061 Durham Road West, Columbia, MD 21044, USA mbevans@cc.nih.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 615 EP - 622 PB - John Wiley, Chichester UK VL - 20 IS - 6 SN - 1057-9249, 1057-9249 KW - cancer, oncology, distress thermometer, distress screening, validity, accuracy KW - Screening KW - Symptoms KW - Sensitivity KW - Stem cells KW - Psychological distress KW - Carers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896166070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psycho-Oncology&rft.atitle=Distress+screening+in+allogeneic+hematopoietic+stem+cell+%28HSCT%29+caregivers+and+patients&rft.au=Bevans%2C+Margaret%3BWehrlen%2C+Leslie%3BPrachenko%2C+Olena%3BSoeken%2C+Karen%3BZabora%2C+James%3BWallen%2C+Gwenyth+R&rft.aulast=Bevans&rft.aufirst=Margaret&rft.date=2011-06-01&rft.volume=20&rft.issue=6&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=Psycho-Oncology&rft.issn=10579249&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Last updated - 2016-09-27 N1 - CODEN - POJCEE N1 - SubjectsTermNotLitGenreText - Carers; Psychological distress; Screening; Sensitivity; Stem cells; Symptoms ER - TY - JOUR T1 - An immunotoxin targeting the gH glycoprotein of KSHV for selective killing of cells in the lytic phase of infection AN - 888100863; 14989846 AB - Amongst the pathologies associated with infection by Kaposi's sarcoma-associated herpesvirus (KSHV), multicentric Castleman's disease is distinctive for involvement of the lytic phase of the virus replication cycle. This B cell lymphoproliferative disorder has shown clinical responsiveness not only to generalized immunotherapy and cytotoxic chemotherapy, but also to inhibitors of herpesvirus DNA replication, consistent with the involvement of lytic phase of replication. These findings suggest that selective killing of virus-producing cells might represent a novel therapeutic strategy. We designed an immunotoxin, YC15-PE38, containing a single chain variable region fragment of a monoclonal antibody against KSHV glycoprotein H (gH) linked to the effector domains of Pseudomonas aeruginosa exotoxin A. Purified YC15-PE38 displayed highly selective and potent killing of a gH-expressing transfectant cell line (subnanomolar IC50). The immunotoxin also strongly inhibited production of infectious KSHV virions from an induced chronically infected cell line, by virtue of selective killing of the virus-producing cells. Combination treatment studies indicated complementary activities between YC15-PE38 and the herpesviral DNA replication inhibitor ganciclovir. These results provide support for the development of anti-KSHV strategies based on targeted killing of infected cells expressing lytic phase genes. JF - Antiviral Research AU - Cai, Yingyun AU - Berger, Edward A AD - Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States, eberger@niaid.nih.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 143 EP - 150 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 90 IS - 3 SN - 0166-3542, 0166-3542 KW - Immunology Abstracts; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Castleman's disease KW - Chemotherapy KW - Cytotoxicity KW - DNA biosynthesis KW - Ganciclovir KW - Glycoproteins KW - Immunoproliferative diseases KW - Immunotherapy KW - Immunotoxins KW - Infection KW - Lymphocytes B KW - Monoclonal antibodies KW - Replication KW - Variable region KW - Virions KW - exotoxin A KW - glycoprotein H KW - Human herpesvirus 8 KW - Kaposi's sarcoma-associated herpesvirus KW - Pseudomonas aeruginosa KW - A 01340:Antibiotics & Antimicrobials KW - F 06910:Microorganisms & Parasites KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888100863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=An+immunotoxin+targeting+the+gH+glycoprotein+of+KSHV+for+selective+killing+of+cells+in+the+lytic+phase+of+infection&rft.au=Cai%2C+Yingyun%3BBerger%2C+Edward+A&rft.aulast=Cai&rft.aufirst=Yingyun&rft.date=2011-06-01&rft.volume=90&rft.issue=3&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2011.03.175 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Virions; DNA biosynthesis; glycoprotein H; Castleman's disease; Lymphocytes B; Replication; Monoclonal antibodies; Chemotherapy; Immunotherapy; Ganciclovir; Infection; exotoxin A; Immunotoxins; Immunoproliferative diseases; Cytotoxicity; Glycoproteins; Variable region; Human herpesvirus 8; Kaposi's sarcoma-associated herpesvirus; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1016/j.antiviral.2011.03.175 ER - TY - JOUR T1 - Recruitment and Retention Strategies for Minority or Poor Clinical Research Participants: Lessons From the Healthy Aging in Neighborhoods of Diversity Across the Life Span Study AN - 887497220; 201103414 AB - Purpose of the study: Investigating health disparities requires studies designed to recruit and retain racially and socioeconomically diverse cohorts. It is critical to address the barriers that disproportionately affect participation in clinical research by minorities and the socioeconomically disadvantaged. This study sought to identify and rectify these barriers to recruit and retain a biracial (African American and non-Hispanic White) and socioeconomically diverse cohort for a longitudinal study. Design and Method: The Healthy Aging in Neighborhoods of Diversity across the Life Span study is a 20-year longitudinal examination of how race and socioeconomic status influence the development of age-related health disparities. One goal was to create a multifactorial recruitment and retention strategy. The recruitment paradigm targeted known barriers and identified those unique to the study's urban environment. The retention paradigm mirrored the recruitment plan but was based on specifically developed approaches. Results: This cohort recruitment required attention to developing community partnerships, designing the research study to meet the study hypotheses and to provide benefit to participants, providing a safe community-based site for the research and creating didactics to develop staff cultural proficiency. These efforts facilitated study implementation and enhanced recruitment resulting in accrual of a biracial and socioeconomically diverse cohort of 3,722 participants. Implications: Recruiting and retaining minority or poor research participants is challenging but possible. The essential facets include clear communication of the research hypothesis, focus on providing a direct benefit for participants, and selection of a hypothesis that is directly relevant to the community studied. Adapted from the source document. JF - The Gerontologist AU - Ejiogu, Ngozi AU - Norbeck, Jennifer H AU - Mason, Marc A AU - Cromwell, Bridget C AU - Zonderman, Alan B AU - Evans, Michele K AD - Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, Baltimore, Maryland Y1 - 2011/06// PY - 2011 DA - June 2011 SP - s33 EP - s45 PB - Gerontological Society of America, Washington DC VL - 51 IS - supplement 1 SN - 0016-9013, 0016-9013 KW - Cultural proficiency, Health disparities, Community-based research platform KW - Cultural Pluralism KW - Black White Differences KW - Attrition KW - Biraciality KW - Aging KW - Constraints KW - Recruitment KW - Neighborhoods KW - Racial Differences KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/887497220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Gerontologist&rft.atitle=Recruitment+and+Retention+Strategies+for+Minority+or+Poor+Clinical+Research+Participants%3A+Lessons+From+the+Healthy+Aging+in+Neighborhoods+of+Diversity+Across+the+Life+Span+Study&rft.au=Ejiogu%2C+Ngozi%3BNorbeck%2C+Jennifer+H%3BMason%2C+Marc+A%3BCromwell%2C+Bridget+C%3BZonderman%2C+Alan+B%3BEvans%2C+Michele+K&rft.aulast=Ejiogu&rft.aufirst=Ngozi&rft.date=2011-06-01&rft.volume=51&rft.issue=supplement+1&rft.spage=s33&rft.isbn=&rft.btitle=&rft.title=The+Gerontologist&rft.issn=00169013&rft_id=info:doi/10.1093%2Fgeront%2Fgnr027 LA - English DB - Social Services Abstracts N1 - Date revised - 2011-09-01 N1 - Last updated - 2016-09-28 N1 - CODEN - GRNTA3 N1 - SubjectsTermNotLitGenreText - Recruitment; Attrition; Constraints; Cultural Pluralism; Neighborhoods; Black White Differences; Biraciality; Aging; Racial Differences DO - http://dx.doi.org/10.1093/geront/gnr027 ER - TY - JOUR T1 - Community Engagement and the Resource Centers for Minority Aging Research AN - 887497191; 201103437 AB - The National Institute on Aging created the Resource Centers for Minority Aging Research (RCMARs) to address infrastructure development intended to reduce health disparities among older adults. The overall goals of the RCMARs are to (a) increase the size of the cadre of researchers conducting research on issues related to minority aging; (b) increase the diversity of researchers conducting research on minority aging; (c) create and test reliable measures for use in older diverse populations; and (d) conduct research on recruitment and retention of community-dwelling older adults for research addressing behavioral, social, and medical issues. Along with this latter goal, the RCMARs developed and maintain academic-community partnerships. To accomplish the recruitment and retention goal, the RCMARs established Community Liaison Working Groups using a collaborative approach to scientific inquiry; this special issue will identify research priorities for moving the science of recruitment and retention forward. In addition, sustainable and efficient methods for fostering long-term partnerships will be identified between community and academia. Evidence-based approaches to the recruitment and retention of diverse elders are explored. We expect this supplement to serve as a catalyst for researchers interested in engaging diverse community-dwelling elders in health-related research. In addition, this supplement should serve as a source of the most contemporary evidence-based approaches to the recruitment and retention of diverse older populations for participation in social, behavioral, and clinical research. Adapted from the source document. JF - The Gerontologist AU - Sood, Johanna R AU - Stahl, Sidney M AD - Division of Behavioral and Social Research, National Institute on Aging, Bethesda, Maryland Y1 - 2011/06// PY - 2011 DA - June 2011 SP - s5 EP - s7 PB - Gerontological Society of America, Washington DC VL - 51 IS - supplement 1 SN - 0016-9013, 0016-9013 KW - Population Growth KW - Attrition KW - Cooperation KW - Aging KW - Recruitment KW - Elderly KW - Social Participation KW - Evidence Based Practice KW - Cadres KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/887497191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Gerontologist&rft.atitle=Community+Engagement+and+the+Resource+Centers+for+Minority+Aging+Research&rft.au=Sood%2C+Johanna+R%3BStahl%2C+Sidney+M&rft.aulast=Sood&rft.aufirst=Johanna&rft.date=2011-06-01&rft.volume=51&rft.issue=supplement+1&rft.spage=s5&rft.isbn=&rft.btitle=&rft.title=The+Gerontologist&rft.issn=00169013&rft_id=info:doi/10.1093%2Fgeront%2Fgnr036 LA - English DB - Social Services Abstracts N1 - Date revised - 2011-09-01 N1 - Last updated - 2016-09-28 N1 - CODEN - GRNTA3 N1 - SubjectsTermNotLitGenreText - Elderly; Attrition; Recruitment; Aging; Evidence Based Practice; Social Participation; Cooperation; Cadres; Population Growth DO - http://dx.doi.org/10.1093/geront/gnr036 ER - TY - JOUR T1 - Comparison of elliptical training, stationary cycling, treadmill walking and overground walking AN - 883039495; 15315834 AB - The extent to which therapeutic, exercise or robotic devices can maximize gait function is a major unresolved issue in neurorehabilitation. Several factors may influence gait outcomes such as similarity of the task to overground walking, degree of coordination within and across limbs, and cycle-to-cycle variability in each device. Our objective was to compare lower extremity kinematics, coordination and variability during four locomotor tasks: overground walking, treadmill walking, elliptical training and stationary cycling in 10 non-disabled adults (6 male; mean age 22.7 +/- 2.9 yrs, range 20-29). All first performed four overground walking trials at self-selected speed with mean temporal-spatial data used to pace the other conditions. Joint positions, excursions, and the Gait Deviation Index (GDI) were compared across conditions to evaluate kinematic similarity. Time-series data were correlated within and across limbs to evaluate intralimb and interlimb coordination, respectively. Variability in cadence was quantified to assess how constrained the locomotor rhythm was compared to overground walking. Treadmill walking most closely resembled overground with GDI values nearly overlapping, reinforcing its appropriateness for gait training. Cycling showed the largest GDI difference from overground, with elliptical closer but still a significant distance from all three. Cycling showed greater hip reciprocation Cycling and elliptical showed stronger intralimb synergism at the hip and knee than the other two. Based on kinematics, results suggest that elliptical training may have greater transfer to overground walking than cycling and cycling may be more useful for enhancing reciprocal coordination. Further evaluation of these devices in neurological gait disorders is needed. JF - Gait & Posture AU - Damiano, Diane L AU - Norman, Tracy AU - Stanley, Christopher J AU - Park, Hyung-Soon AD - Functional and Applied Biomechanics Section, Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, United States, damianod@cc.nih.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 260 EP - 264 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 34 IS - 2 SN - 0966-6362, 0966-6362 KW - Physical Education Index KW - Bicycling KW - Kinematics KW - Coordination KW - Pace KW - Speed KW - Walking KW - Gait KW - Treadmill ergometry KW - Hips KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883039495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gait+%26+Posture&rft.atitle=Comparison+of+elliptical+training%2C+stationary+cycling%2C+treadmill+walking+and+overground+walking&rft.au=Damiano%2C+Diane+L%3BNorman%2C+Tracy%3BStanley%2C+Christopher+J%3BPark%2C+Hyung-Soon&rft.aulast=Damiano&rft.aufirst=Diane&rft.date=2011-06-01&rft.volume=34&rft.issue=2&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Gait+%26+Posture&rft.issn=09666362&rft_id=info:doi/10.1016%2Fj.gaitpost.2011.05.010 LA - English DB - Physical Education Index N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Bicycling; Kinematics; Speed; Pace; Coordination; Walking; Gait; Hips; Treadmill ergometry DO - http://dx.doi.org/10.1016/j.gaitpost.2011.05.010 ER - TY - JOUR T1 - Predictors of Extraordinary Survival in the Iowa Established Populations for Epidemiologic Study of the Elderly: Cohort Follow-Up to "Extinction" AN - 883025519; 15213276 AB - DESIGN: Longitudinal study of a cohort of elderly people followed up until almost all have died. SETTING: Two counties in Iowa; a part of the Established Populations for Epidemiologic Study of the Elderly. PARTICIPANTS: Two thousand eight hundred ninety community-dwelling citizens aged 65 to 85 at baseline and surviving at least 3 years. MEASUREMENTS: Data relating to age, sex, birth order, parental longevity, marital status, education, family income, social support, self-reported health, chronic diseases, blood pressure, body mass index, physical ability, exercise, life attitude and mental health were obtained. Extraordinary survivors (ESs) were defined to include approximately 10% of the longest survivors in their sex group. RESULTS: The 253 ESs were far more likely never to have smoked. In models adjusted for age, sex, and smoking, the earlier-life factors such as parental longevity, being earlier in the birth order (in women only), and body mass index at age 50 were associated with extraordinary survival. In similar models for predictors at age 65 to 85, extraordinary survival was associated with excellent self-reported health, fewer chronic diseases, better physical mobility and memory, and positive attitude toward life, but it was not associated with depression, anxiety, or sleep quality. In multivariable models, attitude toward life was not an independent predictor. Women in the top third of a cumulative score of independent predictors were 9.3 (95% confidence interval=4.4-19.6, P<.001) times as likely to reach extraordinary survival as those in the bottom third. CONCLUSION: ESs had fewer "classical" risk factors and were in better health than their contemporaneous controls. Possibly genetic factors such as parental longevity and birth order appear to be less predictive in men than in women.Original Abstract: OBJECTIVES: To identify predictors of extraordinary survival. JF - Journal of the American Geriatrics Society AU - Dutta, Ambarish AU - Henley, William AU - Lang, Iain AU - Llewellyn, David AU - Guralnik, Jack AU - Wallace, Robert B AU - Melzer, David AD - From the*Epidemiology and Public Health Group, Peninsula Medical School, University of Exeter, Exeter, United Kingdom; National Institute on Aging, National Institutes of Health, Bethesda, Maryland; and Department of Epidemiology, Centre on Aging, College of Public Health, University of Iowa, Iowa. Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 963 EP - 971 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 6 SN - 0002-8614, 0002-8614 KW - Risk Abstracts KW - Age KW - Education KW - Mobility KW - attitudes KW - body mass KW - elderly KW - longevity KW - longitudinal studies KW - survival KW - USA, Iowa KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883025519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Predictors+of+Extraordinary+Survival+in+the+Iowa+Established+Populations+for+Epidemiologic+Study+of+the+Elderly%3A+Cohort+Follow-Up+to+%22Extinction%22&rft.au=Dutta%2C+Ambarish%3BHenley%2C+William%3BLang%2C+Iain%3BLlewellyn%2C+David%3BGuralnik%2C+Jack%3BWallace%2C+Robert+B%3BMelzer%2C+David&rft.aulast=Dutta&rft.aufirst=Ambarish&rft.date=2011-06-01&rft.volume=59&rft.issue=6&rft.spage=963&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2011.03451.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Document feature - figure 1 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Education; Age; Mobility; body mass; elderly; longevity; survival; longitudinal studies; attitudes; USA, Iowa DO - http://dx.doi.org/10.1111/j.1532-5415.2011.03451.x ER - TY - JOUR T1 - The relationship between alloimmunization and posttransfusion granulocyte survival: experience in a chronic granulomatous disease cohort AN - 883020828; 15214759 AB - BACKGROUND: The efficacy of granulocyte transfusions in patients with HLA alloimmunization is uncertain. A flow cytometric assay using dihydrorhodamine 123 (DHR), a marker for cellular NADPH oxidase activity, was used to monitor the differential survival of transfused oxidase-positive granulocytes in alloimmunized patients with chronic granulomatous disease (CGD). STUDY DESIGN AND METHODS: Ten patients with CGD and serious infections were treated with daily granulocyte transfusions derived from steroid and granulocyte-colony-stimulating factor-stimulated donors. The proportion of neutrophils with intact oxidase activity was quantitated by DHR fluorescence on samples drawn before and 1 hour after transfusion. The incidence of acute transfusion reactions was correlated with the results of DHR fluorescence and biweekly HLA serologic screening assays. RESULTS: Eight of 10 patients experienced acute adverse reactions in association with granulocyte transfusions. Four had only chills and/or fever, and four experienced respiratory compromise; all eight exhibited HLA alloimmunization. Mean (+/-SD) oxidase-positive cell recovery was 19.7+/-17.4% (n=15 transfusions) versus 0.95+/-1.59% (n=16) in the absence and presence of HLA allosensitization, respectively (p<0.01). Greater than 1% in vivo recovery of DHR-enhancing donor granulocytes was strongly correlated with lack of HLA alloimmunization. CONCLUSION: The ability to detect DHR-positive donor granulocytes by flow cytometry is strongly correlated with absence of HLA alloimmunization and lack of acute reactions to granulocyte transfusions in patients with CGD. If HLA antibodies are present and the survival of donor granulocytes is low by DHR analysis, transfusions should be discontinued, avoiding a therapy associated with high risk and unclear benefit. JF - Transfusion AU - Heim, K F AU - Fleisher, T A AU - Stroncek, D F AU - Holland, S M AU - Gallin, JI AU - Malech, H L AU - Leitman, S F AD - From the Departments of Transfusion Medicine and Laboratory Medicine, Warren Grant Magnuson Clinical Center and the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland. Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 1154 EP - 1162 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 51 IS - 6 SN - 0041-1132, 0041-1132 KW - Risk Abstracts KW - Fluorescence KW - Side effects KW - infection KW - steroids KW - survival KW - transfusion KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883020828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=The+relationship+between+alloimmunization+and+posttransfusion+granulocyte+survival%3A+experience+in+a+chronic+granulomatous+disease+cohort&rft.au=Heim%2C+K+F%3BFleisher%2C+T+A%3BStroncek%2C+D+F%3BHolland%2C+S+M%3BGallin%2C+JI%3BMalech%2C+H+L%3BLeitman%2C+S+F&rft.aulast=Heim&rft.aufirst=K&rft.date=2011-06-01&rft.volume=51&rft.issue=6&rft.spage=1154&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2010.02993.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Document feature - figure 0 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Fluorescence; infection; steroids; transfusion; survival; Side effects DO - http://dx.doi.org/10.1111/j.1537-2995.2010.02993.x ER - TY - JOUR T1 - Treatment of canine leukocyte adhesion deficiency by foamy virus vectors expressing CD18 from a PGK promoter AN - 883015796; 15164374 AB - Proto-oncogene activation caused by retroviral vector integration can cause malignancies in gene therapy trials. This has led investigators to search for less genotoxic vectors with minimal enhancer activity and a decreased risk of influencing neighboring chromosomal gene expression after integration. We previously showed that foamy virus (FV) vectors expressing the canine CD18 gene from an internal murine stem cell virus (MSCV) promoter could cure canine leukocyte adhesion deficiency (LAD). Here, we have repeated these studies using a FV vector expressing canine CD18 from a phosphoglycerate kinase (PGK) gene promoter. In vitro analysis showed that this vector did not contain an enhancer that activated neighboring genes, and it expressed CD18 efficiently in canine neutrophils and CD34+ cells. However, dogs that received hematopoietic stem cells transduced with the PGK-CD18 vector continued to suffer from LAD, and sometimes died prematurely of the disease. These studies show that the PGK promoter cannot effectively replace the MSCV promoter in CD18-expressing FV vectors, and they suggest that vectors containing a strong promoter-enhancer may be necessary for the treatment of human LAD. JF - Gene Therapy AU - Bauer, T R AU - Olson, E M AU - Huo, Y AU - Tuschong, L M AU - Allen, J M AU - Li, Y AU - Burkholder, T H AU - Russell, D W AD - Experimental Transplantation and Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 553 EP - 559 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 18 IS - 6 SN - 0969-7128, 0969-7128 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene therapy KW - Foamy virus KW - Genotoxicity KW - Leukocytes (neutrophilic) KW - CD34 antigen KW - CD18 antigen KW - Fv KW - Expression vectors KW - Integration KW - Enhancers KW - Promoters KW - Phosphoglycerate kinase KW - pgk gene KW - Malignancy KW - Stem cells KW - Proto-oncogenes KW - W 30905:Medical Applications KW - G 07730:Development & Cell Cycle KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883015796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Treatment+of+canine+leukocyte+adhesion+deficiency+by+foamy+virus+vectors+expressing+CD18+from+a+PGK+promoter&rft.au=Bauer%2C+T+R%3BOlson%2C+E+M%3BHuo%2C+Y%3BTuschong%2C+L+M%3BAllen%2C+J+M%3BLi%2C+Y%3BBurkholder%2C+T+H%3BRussell%2C+D+W&rft.aulast=Bauer&rft.aufirst=T&rft.date=2011-06-01&rft.volume=18&rft.issue=6&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2010.169 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Gene therapy; Genotoxicity; Leukocytes (neutrophilic); CD34 antigen; CD18 antigen; Fv; Expression vectors; Phosphoglycerate kinase; Promoters; Enhancers; Integration; Stem cells; Malignancy; pgk gene; Proto-oncogenes; Foamy virus DO - http://dx.doi.org/10.1038/gt.2010.169 ER - TY - JOUR T1 - Formation of the spinal network in zebrafish determined by domain-specific pax genes AN - 879477822; 15133938 AB - In the formation of the spinal network, various transcription factors interact to develop specific cell types. By using a gene trap technique, we established a stable line of zebrafish in which the red fluorescent protein (RFP) was inserted into the pax8 gene. RFP insertion marked putative pax8-lineage cells with fluorescence and inhibited pax8 expression in homozygous embryos. Pax8 homozygous embryos displayed defects in the otic vesicle, as previously reported in studies with morpholinos. The pax8 homozygous embryos survived to adulthood, in contrast to mammalian counterparts that die prematurely. RFP is expressed in the dorsal spinal cord. Examination of the axon morphology revealed that RFP super(+) neurons include commissural bifurcating longitudinal (CoBL) interneurons, but other inhibitory neurons such as commissural local (CoLo) interneurons and circumferential ascending (CiA) interneurons do not express RFP. We examined the effect of inhibiting pax2a/pax8 expression on interneuron development. In pax8 homozygous fish, the RFP super(+) cells underwent differentiation similar to that of pax8 heterozygous fish, and the swimming behavior remained intact. In contrast, the RFP super(+) cells of pax2a/pax8 double mutants displayed altered cell fates. CoBLs were not observed. Instead, RFP super(+) cells exhibited axons descending ipsilaterally, a morphology resembling that of V2a/V2b interneurons. J. Comp. Neurol. 519:1562-1579, 2011. 2010 Wiley-Liss, Inc. JF - Journal of Comparative Neurology AU - Ikenaga, Takanori AU - Urban, Jason M AU - Gebhart, Nichole AU - Hatta, Kohei AU - Kawakami, Koichi AU - Ono, Fumihito AD - Laboratory of Molecular Physiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, onof@mail.nih.gov Y1 - 2011/06/01/ PY - 2011 DA - 2011 Jun 01 SP - 1562 EP - 1579 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 519 IS - 8 SN - 1096-9861, 1096-9861 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; ASFA 1: Biological Sciences & Living Resources; CSA Neurosciences Abstracts KW - Fluorescence KW - Swimming behavior KW - Spinal cord KW - Embryonic development KW - Transcription KW - Genetic diversity KW - Freshwater KW - Freshwater fish KW - Danio rerio KW - Differentiation KW - Interneurons KW - Pax8 protein KW - Genes KW - red fluorescent protein KW - Transcription factors KW - Neurons KW - Pax8 gene KW - Vesicles KW - Axons KW - Embryos KW - Cell fate KW - Q1 08563:Fishing gear and methods KW - A 01490:Miscellaneous KW - G 07730:Development & Cell Cycle KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879477822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Comparative+Neurology&rft.atitle=Formation+of+the+spinal+network+in+zebrafish+determined+by+domain-specific+pax+genes&rft.au=Ikenaga%2C+Takanori%3BUrban%2C+Jason+M%3BGebhart%2C+Nichole%3BHatta%2C+Kohei%3BKawakami%2C+Koichi%3BOno%2C+Fumihito&rft.aulast=Ikenaga&rft.aufirst=Takanori&rft.date=2011-06-01&rft.volume=519&rft.issue=8&rft.spage=1562&rft.isbn=&rft.btitle=&rft.title=Journal+of+Comparative+Neurology&rft.issn=10969861&rft_id=info:doi/10.1002%2Fcne.22585 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2014-05-15 N1 - SubjectsTermNotLitGenreText - Genes; Spinal cord; Neurons; Embryonic development; Genetic diversity; Transcription; Freshwater fish; Fluorescence; Swimming behavior; Differentiation; Pax8 protein; Interneurons; red fluorescent protein; Transcription factors; Pax8 gene; Embryos; Axons; Vesicles; Cell fate; Danio rerio; Freshwater DO - http://dx.doi.org/10.1002/cne.22585 ER - TY - JOUR T1 - Gene Therapy for Canine Leukocyte Adhesion Deficiency with Lentiviral Vectors Using the Murine Stem Cell Virus and Human Phosphoglycerate Kinase Promoters AN - 879477601; 15204336 AB - Children with leukocyte adhesion deficiency type 1 (LAD-1) and dogs with canine LAD (CLAD) develop life-threatening bacterial infections due to mutations in the leukocyte integrin CD18. Here, we compared the human phosphoglycerate kinase (hPGK) promoter to the murine stem cell virus (MSCV) promoter/enhancer in a self-inactivating HIV-1-derived lentiviral vector to treat animals with CLAD. Four CLAD dogs were infused with CD34 super(+) cells transduced with the hPGK vector, and two CLAD dogs received MSCV vector-transduced CD34 super(+)cells. Infusions were preceded by a nonmyeloablative dose of 200 cGy total body irradiation. Comparable numbers of transduced cells were infused in each group of animals. Only one of four CLAD animals treated with the hPGK-cCD18 vector had reversal of CLAD, whereas both MSCV-cCD18 vector-treated dogs had reversal of the phenotype. Correction of CLAD depends both upon the percentage of CD18 super(+) myeloid cells and the level of expression of CD18 on individual myeloid cells. In this regard, the hPGK promoter directed low levels of expression of CD18 on neutrophils compared to the MSCV promoter, likely contributing to the suboptimal clinical outcome with the hPGK vector. JF - Human Gene Therapy AU - Hunter, MJ AU - Zhao, H AU - Tuschong, L M AU - Bauer, TR Jr AU - Burkholder, TH AU - Persons, DA AU - Hickstein, D D AD - Experimental Transplantation and Immunology Branch National Cancer Institute National Institutes of Health 10 Center Drive, MSC1203 Bldg 10-CRC, Room 3-3264 Bethesda, MD 20892-1203, USA, huntermj@mail.nih.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 689 EP - 696 VL - 22 IS - 6 SN - 1043-0342, 1043-0342 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene therapy KW - Leukocytes (neutrophilic) KW - CD34 antigen KW - Infection KW - Myeloid cells KW - Children KW - CD18 antigen KW - Expression vectors KW - Enhancers KW - Phosphoglycerate kinase KW - Promoters KW - Stem cells KW - Radiation KW - Human immunodeficiency virus KW - Integrins KW - Mutation KW - J 02410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials KW - W 30905:Medical Applications KW - V 22360:AIDS and HIV KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879477601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Gene+Therapy+for+Canine+Leukocyte+Adhesion+Deficiency+with+Lentiviral+Vectors+Using+the+Murine+Stem+Cell+Virus+and+Human+Phosphoglycerate+Kinase+Promoters&rft.au=Hunter%2C+MJ%3BZhao%2C+H%3BTuschong%2C+L+M%3BBauer%2C+TR+Jr%3BBurkholder%2C+TH%3BPersons%2C+DA%3BHickstein%2C+D+D&rft.aulast=Hunter&rft.aufirst=MJ&rft.date=2011-06-01&rft.volume=22&rft.issue=6&rft.spage=689&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2010.130 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Gene therapy; Leukocytes (neutrophilic); CD34 antigen; Children; Myeloid cells; Infection; CD18 antigen; Expression vectors; Promoters; Phosphoglycerate kinase; Enhancers; Stem cells; Radiation; Integrins; Mutation; Human immunodeficiency virus DO - http://dx.doi.org/10.1089/hum.2010.130 ER - TY - JOUR T1 - Height at diagnosis and birth-weight as risk factors for osteosarcoma AN - 876237570; 14895520 AB - Objectives : Osteosarcoma typically occurs during puberty. Studies of the association between height and/or birth-weight and osteosarcoma are conflicting. Therefore, we conducted a large pooled analysis of height and birth-weight in osteosarcoma. Methods: Patient data from seven studies of height and three of birth-weight were obtained, resulting in 1,067 cases with height and 434 cases with birth-weight data. We compared cases to the 2000 US National Center for Health Statistics Growth Charts by simulating 1,000 age- and gender-matched controls per case. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for associations between height or birth-weight and risk of osteosarcoma for each study were estimated using logistic regression. All of the case data were combined for an aggregate analysis. Results: Compared to average birth-weight subjects (2,665-4,045g), individuals with high birth-weight ( greater than or equal to 4,046g) had an increased osteosarcoma risk (OR 1.35, 95% CI 1.01-1.79). Taller than average (51st-89th percentile) and very tall individuals ( greater than or equal to 90th percentile) had an increased risk of osteosarcoma (OR 1.35, 95% CI 1.18-1.54 and OR 2.60, 95% CI 2.19-3.07, respectively; P sub(trend)<0.0001). Conclusions: This is the largest analysis of height at diagnosis and birth-weight in relation to osteosarcoma. It suggests that rapid bone growth during puberty and in utero contributes to OS etiology. JF - Cancer Causes & Control AU - Mirabello, Lisa AU - Pfeiffer, Ruth AU - Murphy, Gwen AU - Daw, Najat C AU - Patino-Garcia, Ana AU - Troisi, Rebecca J AU - Hoover, Robert N AU - Douglass, Chester AU - Schuz, Joachim AU - Craft, Alan W AU - Savage, Sharon A AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, mirabellol@mail.nih.gov mirabellol@mail.nih.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 899 EP - 908 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 22 IS - 6 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Bone KW - Etiology KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876237570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Height+at+diagnosis+and+birth-weight+as+risk+factors+for+osteosarcoma&rft.au=Mirabello%2C+Lisa%3BPfeiffer%2C+Ruth%3BMurphy%2C+Gwen%3BDaw%2C+Najat+C%3BPatino-Garcia%2C+Ana%3BTroisi%2C+Rebecca+J%3BHoover%2C+Robert+N%3BDouglass%2C+Chester%3BSchuz%2C+Joachim%3BCraft%2C+Alan+W%3BSavage%2C+Sharon+A&rft.aulast=Mirabello&rft.aufirst=Lisa&rft.date=2011-06-01&rft.volume=22&rft.issue=6&rft.spage=899&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9763-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Bone; Etiology; Cancer DO - http://dx.doi.org/10.1007/s10552-011-9763-2 ER - TY - JOUR T1 - THE CHALLENGE OF DISTINGUISHING HIGH-VOLUME AND FREQUENT RISKY DRINKING AN - 876237319; 14887122 JF - Addiction AU - Dawson, Deborah A AD - Laboratory of Epidemiology & Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane Room 3071 MSC9403, Bethesda, MD 20892-9304, USA. E-mail: deborah.anne.dawsonmail.com Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 1046 EP - 1047 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 106 IS - 6 SN - 0965-2140, 0965-2140 KW - Risk Abstracts KW - Alcohol KW - Behavior KW - Risk taking KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876237319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=THE+CHALLENGE+OF+DISTINGUISHING+HIGH-VOLUME+AND+FREQUENT+RISKY+DRINKING&rft.au=Dawson%2C+Deborah+A&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2011-06-01&rft.volume=106&rft.issue=6&rft.spage=1046&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2010.03302.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Document feature - figure 0 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Alcohol; Behavior; Risk taking DO - http://dx.doi.org/10.1111/j.1360-0443.2010.03302.x ER - TY - JOUR T1 - A malaria gametocytocidal assay using oxidoreduction indicator, alamarBlue AN - 876237177; 14769151 AB - Efforts to move from malaria control to eradication will require new approaches to block malaria transmission, such as the development of anti-malarial drugs with gametocytocidal activity. Here fluorescent oxidoreduction indicator alamarBlue is used to develop a screen for gametocyte viability. The fluorescent signal increases linearly with gametocyte number (R super(2) = 0.99) and determination of the IC sub(50) of epoxomicin demonstrated the assay was reproducible and sensitive (IC sub(50) 2.16 +/- 0.57 nM, Z'-factor 0.81 +/- 0.01). Six anti-malarials were also tested and at 10 mu M only primaquine and dihydroartemisinin (DHA) had gametocytocidal activity. This new assay provides an important tool to efficiently screen compounds for gametocytocidal activity. JF - Molecular and Biochemical Parasitology AU - Tanaka, Takeshi Q AU - Williamson, Kim C AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, United States Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 160 EP - 163 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 177 IS - 2 SN - 0166-6851, 0166-6851 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources KW - AlamarBlue KW - Drug screening KW - Gametocyte KW - Plasmodium falciparum KW - Screening KW - Parasites KW - Human diseases KW - Primaquine KW - Gametocytes KW - Drug development KW - Malaria KW - Public health KW - Dihydroartemisinin KW - Drugs KW - K 03300:Methods KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876237177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Biochemical+Parasitology&rft.atitle=A+malaria+gametocytocidal+assay+using+oxidoreduction+indicator%2C+alamarBlue&rft.au=Tanaka%2C+Takeshi+Q%3BWilliamson%2C+Kim+C&rft.aulast=Tanaka&rft.aufirst=Takeshi&rft.date=2011-06-01&rft.volume=177&rft.issue=2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Biochemical+Parasitology&rft.issn=01666851&rft_id=info:doi/10.1016%2Fj.molbiopara.2011.02.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Screening; Parasites; Human diseases; Malaria; Drugs; Public health; Primaquine; Gametocytes; Drug development; Dihydroartemisinin; Plasmodium falciparum DO - http://dx.doi.org/10.1016/j.molbiopara.2011.02.005 ER - TY - JOUR T1 - Global Gene Profiling of Spontaneous Hepatocellular Carcinoma in B6C3F1 Mice: Similarities in the Molecular Landscape with Human Liver Cancer AN - 876233034; 15070693 AB - Hepatocellular carcinoma (HCC) is an important cause of morbidity and mortality worldwide. Although the risk factors of human HCC are well known, the molecular pathogenesis of this disease is complex, and in general, treatment options remain poor. The use of rodent models to study human cancer has been extensively pursued, both through genetically engineered rodents and rodent models used in carcinogenicity and toxicology studies. In particular, the B6C3F1 mouse used in the National Toxicology Program (NTP) two-year bioassay has been used to evaluate the carcinogenic effects of environmental and occupational chemicals, and other compounds. The high incidence of spontaneous HCC in the B6C3F1 mouse has challenged its use as a model for chemically induced HCC in terms of relevance to the human disease. Using global gene expression profiling, we identify the dysregulation of several mediators similarly altered in human HCC, including re-expression of fetal oncogenes, upregulation of protooncogenes, downregulation of tumor suppressor genes, and abnormal expression of cell cycle mediators, growth factors, apoptosis regulators, and angiogenesis and extracellular matrix remodeling factors. Although major differences in etiology and pathogenesis remain between human and mouse HCC, there are important similarities in global gene expression and molecular pathways dysregulated in mouse and human HCC. These data provide further support for the use of this model in hazard identification of compounds with potential human carcinogenicity risk, and may help in better understanding the mechanisms of tumorigenesis resulting from chemical exposure in the NTP two-year carcinogenicity bioassay. JF - Toxicologic Pathology AU - Hoenerhoff, Mark J AU - Pandiri, Arun R AU - Lahousse, Stephanie A AU - Hong, Hu-Hua AU - Ton, Tai-Vu AU - Masinde, Tiwanda AU - Auerbach, Scott S AU - Gerrish, Kevin AU - Bushel, Pierre R AU - Shockley, Keith R AU - Peddada, Shyamal D AU - Sills, Robert C AD - Cellular and Molecular Pathology Branch, National Institute of Environmental Health Science, National Institutes of Health, Research Triangle Park, North Carolina, USA, hoenerhm@niehs.nih.gov hoenerhm@niehs.nih.gov hoenerhm@niehs.nih.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 678 EP - 699 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 39 IS - 4 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Tumor suppressor genes KW - Mortality KW - Etiology KW - Apoptosis KW - Data processing KW - Liver cancer KW - Tumorigenesis KW - Cell cycle KW - Landscape KW - Angiogenesis KW - Animal models KW - Morbidity KW - Fetuses KW - Gene expression KW - Oncogenes KW - Carcinogenicity KW - Genetic engineering KW - Risk factors KW - Extracellular matrix KW - Growth factors KW - Hepatocellular carcinoma KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876233034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Global+Gene+Profiling+of+Spontaneous+Hepatocellular+Carcinoma+in+B6C3F1+Mice%3A+Similarities+in+the+Molecular+Landscape+with+Human+Liver+Cancer&rft.au=Hoenerhoff%2C+Mark+J%3BPandiri%2C+Arun+R%3BLahousse%2C+Stephanie+A%3BHong%2C+Hu-Hua%3BTon%2C+Tai-Vu%3BMasinde%2C+Tiwanda%3BAuerbach%2C+Scott+S%3BGerrish%2C+Kevin%3BBushel%2C+Pierre+R%3BShockley%2C+Keith+R%3BPeddada%2C+Shyamal+D%3BSills%2C+Robert+C&rft.aulast=Hoenerhoff&rft.aufirst=Mark&rft.date=2011-06-01&rft.volume=39&rft.issue=4&rft.spage=678&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623311407213 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mortality; Tumor suppressor genes; Etiology; Data processing; Apoptosis; Liver cancer; Landscape; Cell cycle; Tumorigenesis; Animal models; Angiogenesis; Fetuses; Morbidity; Gene expression; Oncogenes; Carcinogenicity; Extracellular matrix; Risk factors; Genetic engineering; Growth factors; Hepatocellular carcinoma DO - http://dx.doi.org/10.1177/0192623311407213 ER - TY - JOUR T1 - Probes for narcotic receptor mediated phenomena. Part 42: Synthesis and in vitro pharmacological characterization of the N-methyl and N-phenethyl analogues of the racemic ortho-c and para-c oxide-bridged phenylmorphans AN - 876232924; 14946444 AB - A new synthesis of N-methyl and N-phenethyl substituted ortho-c and para-c oxide-bridged phenylmorphans, using N-benzyl- rather than N-methyl-substituted intermediates, was used and the pharmacological properties of these compounds were determined. The N-phenethyl substituted ortho-c oxide-bridged phenylmorphan(rac-(3R,6aS,11aS)-2-phenethyl-2,3,4,5,6,11a-hexahydr o -1H-3,6a-methanobenzofuro[2,3-c]azocin-10-ol ( 12)) was found to have the highest [micro]-opioid receptor affinity (K sub(i = 1.1 nM) of all of the a- through f-oxide-bridged phenylmorphans. Functional data ([[super]35S]GTP- gamma -S) showed that the racemate 12 was more than three times more potent than naloxone as an [micro]-opioid antagonist. AB:) JF - Bioorganic and Medicinal Chemistry AU - Kim, Jin-Hee AU - Deschamps, Jeffrey R AU - Rothman, Richard B AU - Dersch, Christina M AU - Folk, John E AU - Cheng, Kejun AU - Jacobson, Arthur E AU - Rice, Kenner C AD - Drug Design and Synthesis Section, Chemical Biology Research Branch, National Institute on Drug Abuse and The National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 5625 Fishers Lane, Room 4N03, Bethesda, MD 20892-9415, USA Y1 - 2011/06/01/ PY - 2011 DA - 2011 Jun 01 SP - 3434 EP - 3443 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 19 IS - 11 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Antibodies KW - Data processing KW - Probes KW - Naloxone KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876232924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Probes+for+narcotic+receptor+mediated+phenomena.+Part+42%3A+Synthesis+and+in+vitro+pharmacological+characterization+of+the+N-methyl+and+N-phenethyl+analogues+of+the+racemic+ortho-c+and+para-c+oxide-bridged+phenylmorphans&rft.au=Kim%2C+Jin-Hee%3BDeschamps%2C+Jeffrey+R%3BRothman%2C+Richard+B%3BDersch%2C+Christina+M%3BFolk%2C+John+E%3BCheng%2C+Kejun%3BJacobson%2C+Arthur+E%3BRice%2C+Kenner+C&rft.aulast=Kim&rft.aufirst=Jin-Hee&rft.date=2011-06-01&rft.volume=19&rft.issue=11&rft.spage=3434&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2011.04.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Antibodies; Data processing; Probes; Naloxone DO - http://dx.doi.org/10.1016/j.bmc.2011.04.028 ER - TY - JOUR T1 - Short-term Toxicity Study of ST-20 (NSC-741804) by Oral Gavage in Sprague-Dawley Rats AN - 876231240; 15070689 AB - ST-20 (sodium 2,2-dimethylbutyrate) is a potential therapeutic agent for treatment of beta -thalassemia and sickle cell disease. A subchronic oral toxicity study was conducted in Sprague-Dawley rats (10/sex/dose) at gavage dosages of 0 (vehicle control), 200, 600, or 1,000 mg/kg, once daily for up to 15 days followed by a 14-day recovery. Ataxia (females), rough coat/thin appearance (males), and decreased body weights were observed at 1,000 mg/kg. Functional observational battery (FOB) deficits were observed more frequently in females and included decreased body tone, rectal temperature, emotional reactivity, neuromotor-neuromuscular activity (as exhibited by a deficit in visual/tactile placing accuracy, ataxia, hind limb dragging, and decreased grip strength), and rearing. ST-20 caused a decrease in WBC/RBC counts and RBC parameters; increase in reticulocytes and red cell inclusion bodies; decrease in total protein, globulin, and glucose; and increase in AG ratio. Micronucleated polychromatic erythrocytes of the bone marrow increased significantly in males at 1,000 mg/kg. Mean liver and kidney weights increased, and hepatocellular hypertrophy was observed in males at 1,000 mg/kg. Toxicologic findings were fully recovered during the 14-day recovery period. In conclusion, the no-observed adverse effect level for FOB and general toxicity was 200 mg/kg following gavage administration of ST-20 for up to 15 consecutive days. JF - Toxicologic Pathology AU - Terse, Pramod S AU - Johnson, Jerry D AU - Hawk, Michael A AU - Ritchie, Glenn D AU - Ryan, Michael J AU - Vasconcelos, Daphne Y AU - Contos, Denise A AU - Perrine, Susan P AU - Peggins, James O AU - Tomaszewski, Joseph E AD - National Cancer Institute, Bethesda, Maryland, USA, tersep@mail.nih.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 614 EP - 622 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 39 IS - 4 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Emotions KW - Body temperature KW - Erythrocytes KW - Glucose KW - Bone marrow KW - Globulins KW - Toxicity KW - Sodium KW - Hypertrophy KW - Limbs KW - Batteries KW - Body weight KW - Kidney KW - Ataxia KW - Liver KW - Inclusion bodies KW - Reticulocytes KW - Sickle cell disease KW - Side effects KW - Sex KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876231240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Short-term+Toxicity+Study+of+ST-20+%28NSC-741804%29+by+Oral+Gavage+in+Sprague-Dawley+Rats&rft.au=Terse%2C+Pramod+S%3BJohnson%2C+Jerry+D%3BHawk%2C+Michael+A%3BRitchie%2C+Glenn+D%3BRyan%2C+Michael+J%3BVasconcelos%2C+Daphne+Y%3BContos%2C+Denise+A%3BPerrine%2C+Susan+P%3BPeggins%2C+James+O%3BTomaszewski%2C+Joseph+E&rft.aulast=Terse&rft.aufirst=Pramod&rft.date=2011-06-01&rft.volume=39&rft.issue=4&rft.spage=614&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623311406933 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Emotions; Body temperature; Erythrocytes; Bone marrow; Glucose; Globulins; Toxicity; Sodium; Hypertrophy; Limbs; Body weight; Batteries; Liver; Ataxia; Kidney; Inclusion bodies; Sickle cell disease; Reticulocytes; Side effects; Sex DO - http://dx.doi.org/10.1177/0192623311406933 ER - TY - JOUR T1 - Indicator microbes correlate with pathogenic bacteria, yeasts and helminthes in sand at a subtropical recreational beach site AN - 876226180; 14888603 AB - Aims: Research into the relationship between pathogens, faecal indicator microbes and environmental factors in beach sand has been limited, yet vital to the understanding of the microbial relationship between sand and the water column and to the improvement of criteria for better human health protection at beaches. The objectives of this study were to evaluate the presence and distribution of pathogens in various zones of beach sand (subtidal, intertidal and supratidal) and to assess their relationship with environmental parameters and indicator microbes at a non-point source subtropical marine beach. Methods and Results: In this exploratory study in subtropical Miami (Florida, USA), beach sand samples were collected and analysed over the course of 6days for several pathogens, microbial source tracking markers and indicator microbes. An inverse correlation between moisture content and most indicator microbes was found. Significant associations were identified between some indicator microbes and pathogens (such as nematode larvae and yeasts in the genus Candida), which are from classes of microbes that are rarely evaluated in the context of recreational beach use. Conclusions: Results indicate that indicator microbes may predict the presence of some of the pathogens, in particular helminthes, yeasts and the bacterial pathogen Staphylococcus aureus including methicillin-resistant forms. Indicator microbes may thus be useful for monitoring beach sand and water quality at non-point source beaches. Significance and Impact of the Study: The presence of both indicator microbes and pathogens in beach sand provides one possible explanation for human health effects reported at non-point sources beaches. JF - Journal of Applied Microbiology AU - Shah, AH AU - Abdelzaher, A M AU - Phillips, M AU - Hernandez, R AU - Solo-Gabriele, H M AU - Kish, J AU - Scorzetti, G AU - Fell, J W AU - Diaz, M R AU - Scott, T M AU - Lukasik, J AU - Harwood, V J AU - McQuaig, S AU - Sinigalliano, C D AU - Gidley, M L AU - Wanless, D AU - Ager, A AU - Lui, J AU - Stewart, J R AU - Plano, LRW AU - Fleming, LE AD - University of Miami, NSF NIEHS Oceans and Human Health Center, Miami, FL, USA Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 1571 EP - 1583 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 110 IS - 6 SN - 1364-5072, 1364-5072 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Beaches KW - Sand KW - Drug resistance KW - Helminthes KW - Candida KW - Pathogens KW - Staphylococcus aureus KW - Water quality KW - Environmental factors KW - Nematoda KW - Water column KW - A 01340:Antibiotics & Antimicrobials KW - K 03450:Ecology KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876226180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Indicator+microbes+correlate+with+pathogenic+bacteria%2C+yeasts+and+helminthes+in+sand+at+a+subtropical+recreational+beach+site&rft.au=Shah%2C+AH%3BAbdelzaher%2C+A+M%3BPhillips%2C+M%3BHernandez%2C+R%3BSolo-Gabriele%2C+H+M%3BKish%2C+J%3BScorzetti%2C+G%3BFell%2C+J+W%3BDiaz%2C+M+R%3BScott%2C+T+M%3BLukasik%2C+J%3BHarwood%2C+V+J%3BMcQuaig%2C+S%3BSinigalliano%2C+C+D%3BGidley%2C+M+L%3BWanless%2C+D%3BAger%2C+A%3BLui%2C+J%3BStewart%2C+J+R%3BPlano%2C+LRW%3BFleming%2C+LE&rft.aulast=Shah&rft.aufirst=AH&rft.date=2011-06-01&rft.volume=110&rft.issue=6&rft.spage=1571&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fj.1365-2672.2011.05013.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Document feature - figure 1 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Beaches; Sand; Drug resistance; Pathogens; Water quality; Environmental factors; Water column; Helminthes; Candida; Staphylococcus aureus; Nematoda DO - http://dx.doi.org/10.1111/j.1365-2672.2011.05013.x ER - TY - JOUR T1 - Association of serum alpha -tocopherol with sex steroid hormones and interactions with smoking: implications for prostate cancer risk AN - 876225804; 14895511 AB - Background: Vitamin E may protect against prostate cancer, possibly only in smokers and, we hypothesize, through altered sex steroid hormones. A controlled trial in smokers showed that sex hormone levels were inversely associated with baseline serum alpha -tocopherol and decreased in response to vitamin E supplementation. The vitamin E-hormone relation is understudied in non-smokers. Methods: Serum sex steroid hormones and alpha -tocopherol were measured for 1,457 men in NHANES III. Multivariable-adjusted geometric mean hormone concentrations by alpha -tocopherol quintile were estimated. Results: We observed lower mean testosterone, estradiol, and SHBG concentrations with increasing serum alpha -tocopherol (Q1=5.5 and Q5=4.6ng/ml, p-trend=0 .0007; Q1=37.8 and Q5=33.1pg/ml, p-trend=0.02; Q1=38.8 and Q5=30.6pg/ml, p-trend=0 .05, respectively). Interactions between serum alpha -tocopherol and exposure to cigarette smoke for total testosterone, total estradiol, and SHBG were found with the inverse relation observed only among smokers. Conclusions: Results from this nationally representative, cross-sectional study indicate an inverse association between serum alpha -tocopherol and circulating testosterone, estradiol, and SHBG, but only in men who smoked. Our findings support vitamin E selectively influencing sex hormones in smokers and afford possible mechanisms through which vitamin E may impact prostate cancer risk. JF - Cancer Causes & Control AU - Mondul, Alison M AU - Rohrmann, Sabine AU - Menke, Andy AU - Feinleib, Manning AU - Nelson, William G AU - Platz, Elizabeth A AU - Albanes, Demetrius AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USA, mondulam@mail.nih.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 827 EP - 836 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 22 IS - 6 SN - 0957-5243, 0957-5243 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Cancer KW - Cigarettes KW - Clinical trials KW - Hormones KW - Smoke KW - Steroid hormones KW - Vitamins KW - clinical trials KW - prostate cancer KW - steroid hormones KW - vitamins KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876225804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Association+of+serum+alpha+-tocopherol+with+sex+steroid+hormones+and+interactions+with+smoking%3A+implications+for+prostate+cancer+risk&rft.au=Mondul%2C+Alison+M%3BRohrmann%2C+Sabine%3BMenke%2C+Andy%3BFeinleib%2C+Manning%3BNelson%2C+William+G%3BPlatz%2C+Elizabeth+A%3BAlbanes%2C+Demetrius&rft.aulast=Mondul&rft.aufirst=Alison&rft.date=2011-06-01&rft.volume=22&rft.issue=6&rft.spage=827&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9753-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Smoke; vitamins; Cigarettes; Vitamins; steroid hormones; Steroid hormones; clinical trials; prostate cancer; Clinical trials; Hormones; Cancer DO - http://dx.doi.org/10.1007/s10552-011-9753-4 ER - TY - JOUR T1 - Energy metabolism affects susceptibility of Anopheles gambiae mosquitoes to Plasmodium infection AN - 876225728; 14878934 AB - Previous studies showed that Anopheles gambiae L3-5 females, which are refractory (R) to Plasmodium infection, express higher levels of genes involved in redox-metabolism and mitochondrial respiration than susceptible (S) G3 females. Our studies revealed that R females have reduced longevity, faster utilization of lipid reserves, impaired mitochondrial state-3 respiration, increased rate of mitochondrial electron leak and higher expression levels of several glycolytic enzyme genes. Furthermore, when state-3 respiration was reduced in S females by silencing expression of the adenine nucleotide translocator (ANT), hydrogen peroxide generation was higher and the mRNA levels of lactate dehydrogenase increased in the midgut, while the prevalence and intensity of Plasmodium berghei infection were significantly reduced. We conclude that there are broad metabolic differences between R and S An. gambiae mosquitoes that influence their susceptibility to Plasmodium infection. JF - Insect Biochemistry and Molecular Biology AU - Oliveira, Jose Henrique M AU - Goncalves, Renata LS AU - Oliveira, Giselle A AU - Oliveira, Pedro L AU - Oliveira, Marcus F AU - Barillas-Mury, Carolina AD - LaboratA3rio de BioquASHmica de ArtrA3podes HematA3fagos, Instituto de BioquASHmica MACOdica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil, cbarillas@niaid.nih.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 349 EP - 355 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 41 IS - 6 SN - 0965-1748, 0965-1748 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; Entomology Abstracts KW - Mosquito KW - Anopheles gambiae KW - Metabolism KW - Mitochondria KW - Plasmodium infection KW - Refractoriness KW - Electron leak KW - Reactive oxygen species KW - Lipids KW - Respiration KW - Infection KW - Molecular biology KW - Potential resources KW - Hydrogen peroxide KW - Adenine KW - Midgut KW - Aquatic insects KW - Energy metabolism KW - Lactate KW - Enzymes KW - Pest control KW - Longevity KW - Nucleotides KW - Plasmodium berghei KW - mRNA KW - L-Lactate dehydrogenase KW - Electron transport KW - Glycolysis KW - Dehydrogenases KW - Q1 08484:Species interactions: parasites and diseases KW - Z 05320:Physiology, Anatomy, and Biochemistry KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876225728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Insect+Biochemistry+and+Molecular+Biology&rft.atitle=Energy+metabolism+affects+susceptibility+of+Anopheles+gambiae+mosquitoes+to+Plasmodium+infection&rft.au=Oliveira%2C+Jose+Henrique+M%3BGoncalves%2C+Renata+LS%3BOliveira%2C+Giselle+A%3BOliveira%2C+Pedro+L%3BOliveira%2C+Marcus+F%3BBarillas-Mury%2C+Carolina&rft.aulast=Oliveira&rft.aufirst=Jose+Henrique&rft.date=2011-06-01&rft.volume=41&rft.issue=6&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Insect+Biochemistry+and+Molecular+Biology&rft.issn=09651748&rft_id=info:doi/10.1016%2Fj.ibmb.2011.02.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Molecular biology; Potential resources; Lactate; Respiration; Pest control; Aquatic insects; Dehydrogenases; Metabolism; Nucleotides; Energy metabolism; Lipids; Mitochondria; Enzymes; Infection; Longevity; L-Lactate dehydrogenase; mRNA; Hydrogen peroxide; Adenine; Midgut; Electron transport; Glycolysis; Anopheles gambiae; Plasmodium berghei DO - http://dx.doi.org/10.1016/j.ibmb.2011.02.001 ER - TY - JOUR T1 - Mechanisms of Short-Term Training-Induced Reaching Improvement in Severely Hemiparetic Stroke Patients: A TMS Study AN - 876225238; 14877037 AB - Background. The neurophysiological mechanisms underlying improved upper-extremity motor skills have been partially investigated in patients with good motor recovery but are poorly understood in more impaired individuals, the majority of stroke survivors. Objective. The authors studied changes in primary motor cortex (M1) excitability (motor evoked potentials [MEPs], contralateral and ipsilateral silent periods [CSPs and ISPs] using transcranial magnetic stimulation [TMS]) associated with training-induced reaching improvement in stroke patients with severe arm paresis (n = 11; Upper-Extremity Fugl-Meyer score (F-M) = 27 +/- 6). Methods. All patients underwent a single session of reaching training focused on moving the affected hand from a resting site to a target placed at 80% of maximum forward reaching amplitude in response to a visual "GO" cue. Triceps contribute primarily as agonist and biceps primarily as antagonist to the trained forward reaching movement. Response times were recorded for each reaching movement. Results. Preceding training (baseline), greater interhemispheric inhibition (measured by ISP) in the affected triceps muscle, reflecting inhibition from the nonlesioned to the lesioned M1, was observed in patients with lower F-M scores (more severe motor impairment). Training-induced improvements in reaching were greater in patients with slower response times at baseline. Increased MEP amplitudes and decreased ISPs and CSPs were observed in the affected triceps but not in the biceps muscle after training. Conclusion. These results indicate that along with training-induced motor improvements, training-specific modulation of intrahemispheric and interhemispheric mechanisms occurs after reaching practice in chronic stroke patients with substantial arm impairment. JF - Neurorehabilitation and Neural Repair AU - Harris-Love, Michelle L AU - Morton, Susanne M AU - Perez, Monica A AU - Cohen, Leonardo G AD - National Rehabilitation Hospital, Georgetown University, Washington, DC, USA, cohenl@ninds.nih.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 398 EP - 411 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 25 IS - 5 SN - 1545-9683, 1545-9683 KW - Physical Education Index; CSA Neurosciences Abstracts KW - Cerebral hemispheres KW - Cortex (motor) KW - Excitability KW - Hand KW - Inhibition KW - Motor evoked potentials KW - Motor skill KW - Motor skills KW - Motor task performance KW - Movement KW - Muscles KW - Neurology KW - Paresis KW - Patients KW - Reaching KW - Reaction time KW - Rehabilitation KW - Stimuli KW - Stroke KW - Transcranial magnetic stimulation KW - Visual stimuli KW - PE 080:Motor Learning KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876225238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurorehabilitation+and+Neural+Repair&rft.atitle=Mechanisms+of+Short-Term+Training-Induced+Reaching+Improvement+in+Severely+Hemiparetic+Stroke+Patients%3A+A+TMS+Study&rft.au=Harris-Love%2C+Michelle+L%3BMorton%2C+Susanne+M%3BPerez%2C+Monica+A%3BCohen%2C+Leonardo+G&rft.aulast=Harris-Love&rft.aufirst=Michelle&rft.date=2011-06-01&rft.volume=25&rft.issue=5&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=Neurorehabilitation+and+Neural+Repair&rft.issn=15459683&rft_id=info:doi/10.1177%2F1545968310395600 LA - English DB - Physical Education Index N1 - Date revised - 2011-07-01 N1 - Number of references - 74 N1 - Last updated - 2012-08-24 N1 - SubjectsTermNotLitGenreText - Reaction time; Motor skills; Stroke; Muscles; Stimuli; Patients; Inhibition; Movement; Reaching; Motor skill; Cortex (motor); Paresis; Rehabilitation; Cerebral hemispheres; Motor task performance; Hand; Excitability; Visual stimuli; Transcranial magnetic stimulation; Motor evoked potentials; Neurology DO - http://dx.doi.org/10.1177/1545968310395600 ER - TY - JOUR T1 - The acceleration of wound healing in primates by the local administration of immunostimulatory CpG oligonucleotides AN - 876224591; 14882048 AB - The process of wound healing involves complex interactions between circulating immune cells and local epithelial and endothelial cells. Studies in murine models indicate that cells of the innate immune system activated via their Toll-like receptors (TLR) can accelerate wound healing. This work examines whether immunostimulatory CpG oligodeoxynucleotides (ODN) designed to trigger human immune cells via TLR9 can promote the healing of excisional skin biopsies in rhesus macaques. Results indicate that aKa type CpG ODN significantly accelerate wound closure in non-human primates (p < 0.05). Contributing to this outcome was a CpG-dependent increase in both the production of basic fibroblast growth factor and in keratinocyte migration. Of interest, IL-1I- and TGFI- normally present at sites of skin injury facilitated these effects. Current findings support the conclusion that the local administration of CpG ODN may provide an effective strategy for accelerating wound healing in humans. JF - Biomaterials AU - Yamamoto, Masaki AU - Sato, Takashi AU - Beren, Joel AU - Verthelyi, Daniela AU - Klinman, Dennis M AD - Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, United States Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 4238 EP - 4242 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 32 IS - 18 SN - 0142-9612, 0142-9612 KW - Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - CpG oligonucleotide KW - Primate KW - TLR9 KW - Wound healing KW - BME KW - ODN KW - LPS KW - bFGF KW - Skin KW - Injuries KW - TLR9 protein KW - Immune system KW - Animal models KW - Biopsy KW - CpG islands KW - Primates KW - Oligonucleotides KW - Leukocyte migration KW - Endothelial cells KW - Immunostimulation KW - Macaca mulatta KW - Keratinocytes KW - Fibroblast growth factor 2 KW - Toll-like receptors KW - N 14840:Antisense, Nucleotide Analogs KW - W 30920:Tissue Engineering KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876224591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=The+acceleration+of+wound+healing+in+primates+by+the+local+administration+of+immunostimulatory+CpG+oligonucleotides&rft.au=Yamamoto%2C+Masaki%3BSato%2C+Takashi%3BBeren%2C+Joel%3BVerthelyi%2C+Daniela%3BKlinman%2C+Dennis+M&rft.aulast=Yamamoto&rft.aufirst=Masaki&rft.date=2011-06-01&rft.volume=32&rft.issue=18&rft.spage=4238&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=01429612&rft_id=info:doi/10.1016%2Fj.biomaterials.2011.02.043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Skin; Injuries; Immune system; TLR9 protein; Animal models; Wound healing; Biopsy; CpG islands; Oligonucleotides; Endothelial cells; Leukocyte migration; Immunostimulation; Keratinocytes; Fibroblast growth factor 2; Toll-like receptors; Macaca mulatta; Primates DO - http://dx.doi.org/10.1016/j.biomaterials.2011.02.043 ER - TY - JOUR T1 - The arcuate nucleus and neuropeptide Y contribute to the antitumorigenic effect of calorie restriction. AN - 874297061; 21385308 AB - Calorie restriction (CR) is known to have profound effects on tumor incidence. A typical consequence of CR is hunger, and we hypothesized that the neuroendocrine response to CR might in part mediate CR's antitumor effects. We tested CR under appetite suppression using two models: neuropeptide Y (NPY) knockout mice and monosodium glutamate-injected mice. While CR was protective in control mice challenged with a two-stage skin carcinogenesis model, papilloma development was neither delayed nor reduced by CR in the monosodium glutamate-treated and NPY knockout mice. Adiponectin levels were also not increased by CR in the appetite-suppressed mice. We propose that some of CR's beneficial effects cannot be separated from those imposed on appetite, and that NPY neurons in the arcuate nucleus of the hypothalamus are involved in the translation of reduced intake to downstream physiological and functional benefits. No claim to original US government works. Aging Cell © 2011 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland. JF - Aging cell AU - Minor, Robin K AU - López, Miguel AU - Younts, Caitlin M AU - Jones, Bruce AU - Pearson, Kevin J AU - Anson, Robert Michael AU - Diéguez, Carlos AU - de Cabo, Rafael AD - Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 483 EP - 492 VL - 10 IS - 3 KW - Neuropeptide Y KW - 0 KW - RNA, Messenger KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Sodium Glutamate KW - W81N5U6R6U KW - Index Medicus KW - Animals KW - Neurons -- metabolism KW - Hunger -- physiology KW - Neurons -- drug effects KW - Hunger -- drug effects KW - RNA, Messenger -- analysis KW - Appetite -- drug effects KW - Mice KW - Mice, Knockout KW - 9,10-Dimethyl-1,2-benzanthracene -- adverse effects KW - Neurons -- cytology KW - Tetradecanoylphorbol Acetate -- adverse effects KW - Female KW - Male KW - Appetite -- physiology KW - Arcuate Nucleus of Hypothalamus -- physiology KW - Arcuate Nucleus of Hypothalamus -- cytology KW - Neoplasms, Experimental -- chemically induced KW - Arcuate Nucleus of Hypothalamus -- drug effects KW - Skin Neoplasms -- chemically induced KW - Neuropeptide Y -- deficiency KW - Caloric Restriction KW - Papilloma KW - Sodium Glutamate -- pharmacology KW - Neuropeptide Y -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874297061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aging+cell&rft.atitle=The+arcuate+nucleus+and+neuropeptide+Y+contribute+to+the+antitumorigenic+effect+of+calorie+restriction.&rft.au=Minor%2C+Robin+K%3BL%C3%B3pez%2C+Miguel%3BYounts%2C+Caitlin+M%3BJones%2C+Bruce%3BPearson%2C+Kevin+J%3BAnson%2C+Robert+Michael%3BDi%C3%A9guez%2C+Carlos%3Bde+Cabo%2C+Rafael&rft.aulast=Minor&rft.aufirst=Robin&rft.date=2011-06-01&rft.volume=10&rft.issue=3&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Aging+cell&rft.issn=1474-9726&rft_id=info:doi/10.1111%2Fj.1474-9726.2011.00693.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-13 N1 - Date created - 2011-05-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Brain Res. 1999 Nov 27;848(1-2):101-13 [10612702] Nat Med. 2010 Sep;16(9):1001-8 [20802499] Nat Med. 2001 Aug;7(8):947-53 [11479628] Endocrinology. 2002 Mar;143(3):998-1007 [11861525] J Gerontol A Biol Sci Med Sci. 2002 Jun;57(6):B225-31 [12023258] Hybrid Hybridomics. 2002 Apr;21(2):147-51 [12031105] Obes Res. 2002 Oct;10(10):1016-20 [12376582] Annu Rev Med. 2003;54:131-52 [12525670] Science. 2003 Feb 28;299(5611):1346-51 [12610294] J Cell Biochem. 2004 Feb 1;91(2):258-64 [14743386] Science. 1969 May 9;164(3880):719-21 [5778021] Pharmacol Biochem Behav. 1976 Nov;5(5):551-7 [1019185] Cancer Res. 1990 Sep 15;50(18):6055-61 [2393870] Neuropeptides. 1990 Feb;15(2):101-6 [2080016] Nutrition. 1989 May-Jun;5(3):155-71; discussion 172 [2520283] Endocrinology. 1992 Jun;130(6):3608-16 [1597158] Nature. 1995 Oct 12;377(6549):530-2 [7566151] J Clin Invest. 1995 Nov;96(5):2503-9 [7593641] Nat Med. 1995 Dec;1(12):1311-4 [7489415] Nature. 1996 May 30;381(6581):415-21 [8632796] Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):15043-8 [9844012] Endocrinology. 1999 Oct;140(10):4551-7 [10499510] Cancer Res. 2005 Mar 1;65(5):1719-28 [15753367] Endocr Rev. 2005 May;26(3):439-51 [15897298] Endocrinology. 2005 Sep;146(9):3718-23 [15919742] Endocrinology. 2006 Mar;147(3):1466-73 [16339211] Diabetes. 2006 May;55(5):1327-36 [16644689] Med Hypotheses. 2007;68(1):87-90 [16930851] Peptides. 2007 Feb;28(2):352-6 [17196304] Cell Metab. 2007 Jul;6(1):55-68 [17618856] Neurosci Lett. 2007 Jul 5;422(1):59-63 [17597298] Exp Gerontol. 2007 Aug;42(8):733-44 [17624709] Nature. 2007 Aug 16;448(7155):767-74 [17700693] J Clin Invest. 2007 Sep;117(9):2539-52 [17694178] Am J Clin Nutr. 2007 Sep;86(3):s858-66 [18265479] Behav Brain Res. 2008 May 16;189(1):202-11 [18291538] Cell Metab. 2008 May;7(5):389-99 [18460330] Clin Cancer Res. 2008 Aug 15;14(16):5043-9 [18698022] Nutrition. 2008 Sep;24(9):820-6 [18725078] J Endocrinol. 2009 Jan;200(1):93-105 [18971219] Mol Cell Endocrinol. 2009 Feb 5;299(1):79-88 [19041366] Nat Protoc. 2009;4(9):1350-62 [19713956] FASEB J. 2010 Aug;24(8):2670-9 [20335227] Trends Endocrinol Metab. 2000 Oct;11(8):327-32 [10996528] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1474-9726.2011.00693.x ER - TY - JOUR T1 - Rapid high-resolution three-dimensional mapping of T sub(1 and age-dependent variations in the non-human primate brain using magnetization-prepared rapid gradient-echo (MPRAGE) sequence) AN - 874193329; 14975079 AB - The use of quantitative T sub(1 mapping in neuroscience and neurology has raised strong interest in the development of T) sub(1)-mapping techniques that can measure T sub(1 in the whole brain, with high accuracy and precision and within short imaging and computation times. Here, we present a new inversion-recovery (IR) based T) sub(1)-mapping method using a standard 3D magnetization-prepared rapid gradient-echo (MPRAGE) sequence. By varying only the inversion time (TI), but keeping other parameters constant, MPRAGE image signals become linear to exp(- TI/T sub(1), allowing for accurate T) sub(1) estimation without flip angle correction. We also show that acquiring data at just 3 TIs, with the three different TI values optimized, gives maximum T sub(1 precision per unit time, allowing for new efficient approaches to measure and compute T) sub(1). We demonstrate the use of our method at 7 T to obtain 3D T sub(1 maps of the whole brain in common marmosets at 0.60 mm resolution and within 11 min. T) sub(1) maps from the same individuals were highly reproducible across different days. Across subjects, the peak of cerebral gray matter T sub(1 distribution was 1735 +/- 52 ms, and the lower edge of cerebral white matter T) sub(1) distribution was 1270 +/- 43 ms. We found a significant decrease of T sub(1 in both gray and white matter of the marmoset brain with age over a span of 14 years, in agreement with previous human studies. This application illustrates that MPRAGE-based 3D T) sub(1) mapping is rapid, accurate and precise, and can facilitate high-resolution anatomical studies in neuroscience and neurological diseases. JF - NeuroImage AU - Liu, Junjie V AU - Bock, Nicholas A AU - Silva, Afonso C AD - Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Building 10, Room B1D109, Bethesda, MD 20892-1065, USA, liu@junjie.com Y1 - 2011/06/01/ PY - 2011 DA - 2011 Jun 01 SP - 1154 EP - 1163 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 56 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Age KW - Callithrix KW - Brain KW - W 30910:Imaging KW - N3:11027 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874193329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Rapid+high-resolution+three-dimensional+mapping+of+T+sub%281+and+age-dependent+variations+in+the+non-human+primate+brain+using+magnetization-prepared+rapid+gradient-echo+%28MPRAGE%29+sequence%29&rft.au=Liu%2C+Junjie+V%3BBock%2C+Nicholas+A%3BSilva%2C+Afonso+C&rft.aulast=Liu&rft.aufirst=Junjie&rft.date=2011-06-01&rft.volume=56&rft.issue=3&rft.spage=1154&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2011.02.075 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Brain; Callithrix DO - http://dx.doi.org/10.1016/j.neuroimage.2011.02.075 ER - TY - JOUR T1 - Sunbeds and sunlamps: who used them and their risk for melanoma. AN - 873703482; 21362155 AB - Sunbed/sunlamp use was recently classified as carcinogenic. This report considers characteristics of those who use sunbeds/sunlamps and the effect of sunbed/sunlamp use on their risk for melanoma within a large case-control study carried out in 1991-1992. Females were more likely than males to have used sunbeds/sunlamps. Use by females increased strongly and significantly with younger ages and with the perceived ability to tan. For females, the individual risk for melanoma increased with typical session time and frequency of sessions. Use before age 20, current use and years of use were not significant. The use patterns of occasional and frequent users were very different. We estimate that typical 5-min sessions would increase the risk for melanoma by 19% for frequent users (10+ sessions) and by 3% for occasional users (1-9 sessions). Body sites that are not generally exposed to sunlight were more common sites of primary melanomas for frequent sunbed/sunlamp users. For males, measures of sunbed/sunlamp use were not significantly associated with melanoma risk. John Wiley & Sons A/S. Published 2011. This article is a US Government work and is in the public domain in the USA. JF - Pigment cell & melanoma research AU - Fears, Thomas R AU - Sagebiel, Richard W AU - Halpern, Allan AU - Elder, David E AU - Holly, Elizabeth A AU - Guerry, Dupont AU - Tucker, Margaret A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 574 EP - 581 VL - 24 IS - 3 KW - Index Medicus KW - Age Factors KW - Sex Factors KW - Risk Factors KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Melanoma -- pathology KW - Neoplasms, Radiation-Induced -- etiology KW - Neoplasms, Radiation-Induced -- pathology KW - Sunlight -- adverse effects KW - Neoplasms, Radiation-Induced -- epidemiology KW - Melanoma -- etiology KW - Sunbathing KW - Melanoma -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/873703482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pigment+cell+%26+melanoma+research&rft.atitle=Sunbeds+and+sunlamps%3A+who+used+them+and+their+risk+for+melanoma.&rft.au=Fears%2C+Thomas+R%3BSagebiel%2C+Richard+W%3BHalpern%2C+Allan%3BElder%2C+David+E%3BHolly%2C+Elizabeth+A%3BGuerry%2C+Dupont%3BTucker%2C+Margaret+A&rft.aulast=Fears&rft.aufirst=Thomas&rft.date=2011-06-01&rft.volume=24&rft.issue=3&rft.spage=574&rft.isbn=&rft.btitle=&rft.title=Pigment+cell+%26+melanoma+research&rft.issn=1755-148X&rft_id=info:doi/10.1111%2Fj.1755-148X.2011.00842.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-22 N1 - Date created - 2011-05-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 2000 May;82(9):1593-9 [10789730] Cancer Epidemiol Biomarkers Prev. 2010 Sep;19(9):2401-6 [20826837] Int J Epidemiol. 2000 Jun;29(3):416-23 [10869312] Cancer Res. 2002 Jul 15;62(14):3992-6 [12124332] J Natl Cancer Inst. 2003 Oct 15;95(20):1530-8 [14559875] Arch Dermatol. 1988 Jun;124(6):869-71 [3377516] Lancet. 1989 Aug 26;2(8661):487-90 [2570195] J Am Acad Dermatol. 1991 Apr;24(4):608-12 [1903403] J Am Acad Dermatol. 1993 Feb;28(2 Pt 1):212-7 [8432917] Am J Epidemiol. 1994 Oct 15;140(8):691-9 [7942771] JAMA. 1997 May 14;277(18):1439-44 [9145715] Int J Epidemiol. 1998 Oct;27(5):758-65 [9839730] Int J Epidemiol. 1999 Jun;28(3):418-27 [10405843] Eur J Cancer. 2005 Jan;41(1):45-60 [15617990] Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):562-6 [15767329] J Clin Oncol. 2006 Aug 1;24(22):3590-6 [16728488] J Invest Dermatol. 2008 Dec;128(12):2905-8 [18615112] Am J Prev Med. 2009 Mar;36(3):243-6 [19215849] Lancet Oncol. 2009 Aug;10(8):751-2 [19655431] Pigment Cell Melanoma Res. 2010 Feb;23(1):57-63 [19968819] Cancer Epidemiol Biomarkers Prev. 2010 Jun;19(6):1557-68 [20507845] Eur J Cancer Prev. 2000 Apr;9(2):133-4 [10830582] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1755-148X.2011.00842.x ER - TY - JOUR T1 - ESTIMATION OF THE THYROID DOSES FOR UKRAINIAN CHILDREN EXPOSED IN UTERO AFTER THE CHERNOBYL ACCIDENT AN - 872136781; 14930867 AB - This paper describes methods for estimating thyroid doses to Ukrainian children who were subjects of an epidemi-ological study of prenatal exposure and presents the calculated doses. Participants were 2,582 mother-child pairs in which the mother had been pregnant at the time of the Chernobyl accident on 26 April 1986 or in the 2-3 mo following when super(131)I in fallout was still present. Among these, 1,494 were categorized as "exposed; " a comparison group of 1,088 was considered "relatively unexposed." Individual in utero thyroid dose estimates were found to range from less than 1 mGy to 3,200 mGy, with an arithmetic mean of 72 mGy. Thyroid doses varied primarily according to stage of pregnancy at the time of exposure and level of radioactive contamination at the location of residence. There was a marked difference between the dose distributions of the exposed and comparison groups, although nine children in the latter group had calculated doses in the range 100-200 mGy. For those children who were born after the accident and prior to the end of June 1986, postnatal thyroid doses were also estimated. About 7.7% (200) of the subjects received thyroid doses after birth that were at least 10% of their cumulative doses. JF - Health Physics AU - Likhtarov, I AU - Kovgan, L AU - Chepurny, M AU - Ivanova, O AU - Boyko, Z AU - Ratia, G AU - Masiuk, S AU - Gerasymenko, V AU - Drozdovitch, V AU - Berkovski, V AU - Hatch, M AU - Brenner, A AU - Luckyanov, N AU - Voilleque, P AU - Bouville, A AD - DHHS/NIH/NCI/Division of Cancer Epidemiology and Genetics, Executive Plaza South, EPS-7094, Bethesda, MD 20892, USA, bouvilla@mail.nih.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 583 EP - 593 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 100 IS - 6 SN - 0017-9078, 0017-9078 KW - Pollution Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Ukraine, Chernobyl KW - Prenatal experience KW - Contamination KW - Thyroid KW - Radioactive pollution KW - Children KW - Pregnancy KW - Mathematics KW - Fallout KW - Birth KW - Nuclear power plants KW - prenatal experience KW - Accidents KW - Radioactive fallout KW - X 24390:Radioactive Materials KW - H 8000:Radiation Safety/Electrical Safety KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872136781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=ESTIMATION+OF+THE+THYROID+DOSES+FOR+UKRAINIAN+CHILDREN+EXPOSED+IN+UTERO+AFTER+THE+CHERNOBYL+ACCIDENT&rft.au=Likhtarov%2C+I%3BKovgan%2C+L%3BChepurny%2C+M%3BIvanova%2C+O%3BBoyko%2C+Z%3BRatia%2C+G%3BMasiuk%2C+S%3BGerasymenko%2C+V%3BDrozdovitch%2C+V%3BBerkovski%2C+V%3BHatch%2C+M%3BBrenner%2C+A%3BLuckyanov%2C+N%3BVoilleque%2C+P%3BBouville%2C+A&rft.aulast=Likhtarov&rft.aufirst=I&rft.date=2011-06-01&rft.volume=100&rft.issue=6&rft.spage=583&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0b013e3181ff391a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Birth; Fallout; Accidents; Prenatal experience; Contamination; Thyroid; Children; Mathematics; Pregnancy; Nuclear power plants; prenatal experience; Radioactive fallout; Radioactive pollution; Ukraine, Chernobyl DO - http://dx.doi.org/10.1097/HP.0b013e3181ff391a ER - TY - JOUR T1 - Contributions of gene marking to cell and gene therapies. AN - 871382558; 21261461 AB - The first human genetic modification studies used replication-incompetent integrating vector vectors to introduce marker genes into T lymphocytes and subsequently into hematopoietic stem cells. Such studies have provided numerous insights into the biology of hematopoiesis and immune reconstitution and contributed to clinical development of gene and cell therapies. Tracking of hematopoietic reconstitution and analysis of the origin of residual malignant disease after hematopoietic transplantation has been possible via gene marking. Introduction of selectable marker genes has enabled preselection of specific T-cell populations for tumor and viral immunotherapy and reduced the threat of graft-versus-host disease, improving the survival of patients after allogeneic marrow transplantation. Marking studies in humans, murine xenografts, and large animals have helped optimize conditions for gene transfer into CD34(+) hematopoietic progenitors, contributing to the achievement of gene transfer efficiencies sufficient for clinical benefit in several serious genetic diseases such as X-linked severe combined immunodeficiency and adrenoleukodystrophy. When adverse events linked to insertional mutagenesis arose in clinical gene therapy trials for inherited immunodeficiencies, additional animal studies using gene-marking vectors have greatly increased our understanding of genotoxicity. The knowledge gained from these studies is being translated into new vector designs and clinical protocols, which we hope will continue to improve the efficiency, effectiveness and safety of these promising therapeutic approaches. JF - Human gene therapy AU - Barese, Cecilia N AU - Dunbar, Cynthia E AD - Hematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20852, USA. Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 659 EP - 668 VL - 22 IS - 6 KW - Antigens, CD19 KW - 0 KW - Genetic Markers KW - Receptor, Nerve Growth Factor KW - Index Medicus KW - Animals KW - Antigens, CD19 -- genetics KW - Humans KW - Drug Resistance, Neoplasm -- genetics KW - Receptor, Nerve Growth Factor -- genetics KW - Mice KW - Hematopoietic Stem Cells -- metabolism KW - T-Lymphocytes -- transplantation KW - Hematopoietic Stem Cell Transplantation KW - Genetic Therapy -- methods KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/871382558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+gene+therapy&rft.atitle=Contributions+of+gene+marking+to+cell+and+gene+therapies.&rft.au=Barese%2C+Cecilia+N%3BDunbar%2C+Cynthia+E&rft.aulast=Barese&rft.aufirst=Cecilia&rft.date=2011-06-01&rft.volume=22&rft.issue=6&rft.spage=659&rft.isbn=&rft.btitle=&rft.title=Human+gene+therapy&rft.issn=1557-7422&rft_id=info:doi/10.1089%2Fhum.2010.237 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-28 N1 - Date created - 2011-06-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11871-6 [8876230] Hum Gene Ther. 1997 Mar 20;8(5):615-24 [9095412] Blood. 1997 Jun 1;89(11):4040-6 [9166843] Science. 1997 Jun 13;276(5319):1719-24 [9180086] Immunol Rev. 1997 Jun;157:217-22 [9255632] Blood. 1997 Sep 1;90(5):1777-86 [9292510] Hum Gene Ther. 1997 Jul 20;8(11):1313-9 [9295126] Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12133-8 [9342375] Hum Gene Ther. 1998 May 20;9(8):1157-64 [9625254] Blood. 1998 Aug 15;92(4):1131-41 [9694700] Blood. 1998 Sep 15;92(6):1878-86 [9731044] Nat Med. 1998 Oct;4(10):1201-5 [9771757] Blood. 1998 Dec 15;92(12):4612-21 [9845527] Hum Gene Ther. 1998 Nov 20;9(17):2629-40 [9853529] Leuk Lymphoma. 1999 Jan;32(3-4):279-88 [10037025] Biochem Biophys Res Commun. 1999 Jul 14;260(3):712-7 [10403831] Hum Gene Ther. 1999 Jul 20;10(11):1783-90 [10446918] Blood. 2004 Jan 15;103(2):492-9 [14512305] Blood. 2004 Jun 1;103(11):4070-7 [14962906] Blood. 2004 Jun 1;103(11):4062-9 [14976042] PLoS Biol. 2004 Aug;2(8):E234 [15314653] J Immunol. 2004 Sep 15;173(6):3620-30 [15356106] Cell. 1985 Aug;42(1):71-9 [4016956] N Engl J Med. 1990 Aug 30;323(9):570-8 [2381442] Science. 1991 Mar 15;251(4999):1363-6 [1848369] Blood. 1992 May 15;79(10):2694-700 [1316784] Hum Gene Ther. 1992 Jun;3(3):305-18 [1643150] Blood. 1992 Sep 1;80(5):1120-4 [1325209] Lancet. 1993 Jan 9;341(8837):85-6 [8093407] Lancet. 1993 Nov 6;342(8880):1134-7 [7901474] Blood. 1994 May 15;83(10):3068-76 [7514051] Lancet. 1995 Jan 7;345(8941):9-13 [7799740] Blood. 1995 Jun 1;85(11):3048-57 [7538814] Science. 1995 Oct 20;270(5235):470-5 [7570000] Science. 1995 Oct 20;270(5235):475-80 [7570001] Blood. 1999 Oct 1;94(7):2271-86 [10498599] Lancet. 2004 Dec 18-31;364(9452):2181-7 [15610804] Blood. 2005 Feb 1;105(3):1010-5 [15383461] Blood. 2005 Jun 1;105(11):4255-7 [15687233] Blood. 2005 Jun 1;105(11):4235-46 [15713797] Science. 2005 May 20;308(5725):1171-4 [15905401] Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1457-62 [16432223] J Immunol Methods. 2006 Mar 20;310(1-2):30-9 [16516225] Nat Med. 2006 Apr;12(4):401-9 [16582916] Blood. 2006 May 15;107(10):3865-7 [16439674] Mol Ther. 2006 Jun;13(6):1031-49 [16624621] Nat Biotechnol. 2006 Jun;24(6):687-96 [16732270] Mol Ther. 2006 Oct;14(4):505-13 [16905365] Blood. 2006 Oct 15;108(8):2545-53 [16825499] Science. 2006 Oct 6;314(5796):126-9 [16946036] Mol Ther. 2007 Feb;15(2):355-60 [17235314] Cancer Gene Ther. 2007 Mar;14(3):227-32 [17082794] Blood. 2007 Jun 1;109(11):4698-707 [17327416] Curr Opin Hematol. 2007 Jul;14(4):337-42 [17534158] Hum Gene Ther. 2007 May;18(5):451-6 [17536975] Mol Ther. 2007 Jul;15(7):1248-52 [17505474] Biol Blood Marrow Transplant. 2007 Aug;13(8):913-24 [17640595] Hum Gene Ther. 2007 Aug;18(8):691-700 [17655493] Blood. 2007 Sep 15;110(6):1806-13 [17526860] Bone Marrow Transplant. 2008 Jan;41(2):199-205 [17994122] Mol Ther. 2008 Mar;16(3):439-49 [18227842] Mol Ther. 2008 Apr;16(4):718-25 [18334985] Hum Gene Ther. 2008 Jul;19(7):699-709 [18557699] Mol Ther. 2008 Sep;16(9):1617-23 [18578011] J Clin Invest. 2008 Sep;118(9):3143-50 [18688286] Blood. 2008 Sep 15;112(6):2278-86 [18566328] N Engl J Med. 2009 Jan 29;360(5):447-58 [19179314] Curr Opin Immunol. 2009 Apr;21(2):233-40 [19304471] Blood. 2009 May 28;113(22):5434-43 [19339698] Hum Gene Ther. 2009 Jun;20(6):563-72 [19222366] J Clin Invest. 2009 Jul;119(7):1952-63 [19509470] Blood. 2009 Aug 13;114(7):1319-30 [19414858] Hum Gene Ther. 2009 Sep;20(9):989-98 [19485761] Blood. 2009 Oct 22;114(17):3546-56 [19652199] Mol Ther. 2009 Nov;17(11):1910-8 [19638958] Science. 2009 Nov 6;326(5954):818-23 [19892975] Nat Med. 2009 Dec;15(12):1431-6 [19966782] Nat Med. 1995 Oct;1(10):1017-23 [7489356] Hum Gene Ther. 1996 Mar 20;7(5):655-67 [8845391] Nat Med. 1996 Aug;2(8):876-82 [8705856] Gene Ther. 1996 Feb;3(2):179-83 [8867866] Hum Gene Ther. 2009 Dec;20(12):1607-26 [19689196] Blood. 2010 Feb 4;115(5):925-35 [19880495] Mol Ther. 2010 Apr;18(4):674-83 [20104209] Blood. 2010 Apr 1;115(13):2610-8 [20093403] Gene Ther. 2010 Apr;17(4):511-20 [20016542] J Clin Invest. 2010 Jul;120(7):2345-54 [20551514] Nature. 2010 Sep 16;467(7313):318-22 [20844535] N Engl J Med. 2010 Nov 11;363(20):1918-27 [21067383] Science. 2000 Apr 28;288(5466):669-72 [10784449] Mol Ther. 2000 May;1(5 Pt 1):448-56 [10933966] Stem Cells. 2001;19(2):118-24 [11239166] Int J Hematol. 2001 Jan;73(1):14-22 [11372750] Hum Gene Ther. 2001 Apr 10;12(6):607-17 [11426461] Science. 2002 Apr 19;296(5567):497 [11964471] Science. 2002 Jun 28;296(5577):2410-3 [12089448] Blood. 2002 Oct 15;100(8):2737-43 [12351380] Gene Ther. 2002 Dec;9(23):1633-8 [12424616] Curr Opin Mol Ther. 2002 Oct;4(5):482-90 [12435050] Blood. 2003 Mar 15;101(6):2099-114 [12511419] Nat Med. 2003 Apr;9(4):367-9 [12669036] Science. 2003 Oct 17;302(5644):415-9 [14564000] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/hum.2010.237 ER - TY - JOUR T1 - Commentary: proteooxidotoxic process of aggregation. AN - 870291745; 21594669 AB - A recent editorial entitled "State of Aggregation" (Nat. Neurosci. 2011; 14:399) described the importance of establishing the structural state of pathogenic protein aggregates (Aβ, α-synuclein, huntingtin, etc.) in studies of neurodegenerative disorders. While this is a laudable goal, it is based on the assumption that the neurotoxicity depends upon a specific tertiary structure of the protein aggregates. Here, I describe evidence (not mentioned in the editorial) that suggests that it is not the protein oligomers, per se, that damage neurons. Instead, neurons are damaged by an unseen sequence(s) of chemical reactions that generate reactive oxygen species (ROS), and it is the ROS that cause both protein aggregation and neurotoxicity. The latter "proteooxidotoxicity" mechanism provides an explanation for numerous findings in the field of neurodegenerative disorders, including the inability to identify specific receptors for the pathogenic proteins. JF - Neuromolecular medicine AU - Mattson, Mark P AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA. mattsonm@grc.nia.nih.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 91 EP - 92 VL - 13 IS - 2 KW - Nerve Tissue Proteins KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Cell Aggregation -- physiology KW - Nerve Tissue Proteins -- physiology KW - Oxidative Stress -- physiology KW - Neurons -- metabolism KW - Neurodegenerative Diseases -- metabolism KW - Neurodegenerative Diseases -- pathology KW - Nerve Tissue Proteins -- metabolism KW - Nerve Tissue Proteins -- chemistry KW - Neurons -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/870291745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuromolecular+medicine&rft.atitle=Commentary%3A+proteooxidotoxic+process+of+aggregation.&rft.au=Mattson%2C+Mark+P&rft.aulast=Mattson&rft.aufirst=Mark&rft.date=2011-06-01&rft.volume=13&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Neuromolecular+medicine&rft.issn=1559-1174&rft_id=info:doi/10.1007%2Fs12017-011-8146-x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-01 N1 - Date created - 2011-06-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s12017-011-8146-x ER - TY - JOUR T1 - Pentostatin plus cyclophosphamide safely and effectively prevents immunotoxin immunogenicity in murine hosts. AN - 870290519; 21521777 AB - The success of immunotoxin therapy of cancer is limited by host production of neutralizing antibodies, which are directed toward the Pseudomonas exotoxin A (PE) component. In this proof-of-principle study using a well-established murine model, we hypothesized that a newly developed immune depletion regimen consisting of pentostatin plus cyclophosphamide would abrogate anti-immunotoxin reactivity. BALB/c hosts were injected weekly with recombinant immunotoxin (RIT) SS1P, which is an antimesothelin Fv antibody fragment genetically fused to a 38 kDa portion of PE, and has been evaluated in clinical trials. Experimental cohorts received induction chemotherapy consisting of pentostatin (P) plus cyclophosphamide (C) prior to initial RIT exposure; some cohorts received further maintenance PC therapy of varying intensity just prior to each weekly RIT challenge. Cohorts were monitored for T, B, myeloid cell depletion, and for total anti-SS1P antibody (Ab) formation. Controls uniformly developed anti-SS1P Ab after the third RIT exposure. Induction PC therapy reduced the frequency of hosts with anti-SS1P Ab. Abrogation of antibody generation was improved by maintenance PC therapy: nearly 100% of recipients of intensive PC maintenance were free of anti-SS1P Ab after 9 weekly RIT doses. The most effective PC regimen yielded the greatest degree of host B-cell depletion, moderate T-cell depletion, and minimal myeloid cell depletion. Induction and maintenance PC chemotherapy safely prevented anti-immunotoxin antibody formation with uniform efficacy. These data suggest that immunotoxin therapy might be used in combination with pentostatin plus cyclophosphamide chemotherapy to improve the targeted therapy of cancer. ©2011 AACR. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Mossoba, Miriam E AU - Onda, Masanori AU - Taylor, Justin AU - Massey, Paul R AU - Treadwell, Shirin AU - Sharon, Elad AU - Hassan, Raffit AU - Pastan, Ira AU - Fowler, Daniel H AD - Center for Cancer Research, National Institutes of Health, Experimental Transplantation and Immunology Branch, and Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2011/06/01/ PY - 2011 DA - 2011 Jun 01 SP - 3697 EP - 3705 VL - 17 IS - 11 SN - 1078-0432, 1078-0432 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Neutralizing KW - Antineoplastic Agents KW - Bacterial Proteins KW - SS1(dsFv)PE38 KW - pseudomonas exoprotein A protein, Pseudomonas aeruginosa KW - Pentostatin KW - 395575MZO7 KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Drug Discovery KW - Lymphocyte Count KW - B-Lymphocytes -- drug effects KW - Animals KW - Bacterial Proteins -- antagonists & inhibitors KW - Bacterial Proteins -- immunology KW - Myeloid Cells -- immunology KW - Enzyme-Linked Immunosorbent Assay KW - Mice KW - B-Lymphocytes -- immunology KW - T-Lymphocytes -- drug effects KW - Myeloid Cells -- drug effects KW - Mice, Inbred BALB C KW - T-Lymphocytes -- immunology KW - Pentostatin -- adverse effects KW - Antineoplastic Agents -- pharmacology KW - Antibodies, Monoclonal -- administration & dosage KW - Pentostatin -- pharmacology KW - Cyclophosphamide -- pharmacology KW - Cyclophosphamide -- adverse effects KW - Antineoplastic Agents -- adverse effects KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/870290519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Pentostatin+plus+cyclophosphamide+safely+and+effectively+prevents+immunotoxin+immunogenicity+in+murine+hosts.&rft.au=Mossoba%2C+Miriam+E%3BOnda%2C+Masanori%3BTaylor%2C+Justin%3BMassey%2C+Paul+R%3BTreadwell%2C+Shirin%3BSharon%2C+Elad%3BHassan%2C+Raffit%3BPastan%2C+Ira%3BFowler%2C+Daniel+H&rft.aulast=Mossoba&rft.aufirst=Miriam&rft.date=2011-06-01&rft.volume=17&rft.issue=11&rft.spage=3697&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-11-0493 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-27 N1 - Date created - 2011-06-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Int J Cancer. 1992 Jun 19;51(4):548-54 [1351045] Am J Surg Pathol. 1992 Mar;16(3):259-68 [1599018] Blood. 1993 Oct 15;82(8):2585-94 [7691265] Transplantation. 1994 Jan;57(2):249-56 [7906058] Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):136-40 [8552591] Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):669-74 [9435250] J Clin Oncol. 2005 Apr 20;23(12):2661-8 [15837980] Clin Cancer Res. 2005 Aug 15;11(16):5840-6 [16115924] J Clin Oncol. 2005 Sep 20;23(27):6719-29 [16061911] Eur J Immunol. 2005 Nov;35(11):3099-102 [16231288] Nat Rev Cancer. 2006 Jul;6(7):559-65 [16794638] J Immunol. 2006 Dec 15;177(12):8822-34 [17142785] Blood. 2007 Feb 1;109(3):1307-15 [17018854] Clin Cancer Res. 2007 Mar 1;13(5):1571-5 [17332303] Bioconjug Chem. 2007 May-Jun;18(3):773-84 [17346030] Biol Blood Marrow Transplant. 2007 Sep;13(9):1022-30 [17697964] Clin Cancer Res. 2007 Sep 1;13(17):5144-9 [17785569] Clin Cancer Res. 2007 Dec 1;13(23):7166-71 [18056197] FASEB J. 2008 Mar;22(3):659-61 [17942826] Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11311-6 [18678888] Blood. 2008 Dec 1;112(12):4765-75 [18625883] Curr Drug Targets. 2009 Feb;10(2):131-9 [19199909] Breast Cancer Res Treat. 2009 May;115(1):29-41 [18481173] J Clin Oncol. 2009 Jun 20;27(18):2983-90 [19414673] Clin Cancer Res. 2009 Aug 15;15(16):5274-9 [19671873] Mol Ther. 2009 Sep;17(9):1492-503 [19584819] Adv Drug Deliv Rev. 2009 Sep 30;61(11):977-85 [19679153] J Immunother. 2010 Apr;33(3):297-304 [20445350] Mol Cancer Ther. 2010 Jun;9(6):1872-83 [20530709] Rev Recent Clin Trials. 2011 Jan;6(1):24-35 [20868343] Biol Blood Marrow Transplant. 2011 May;17(5):620-31 [21130889] Cancer Treat Res. 1999;101:97-108 [10800646] J Clin Oncol. 2001 Jan 15;19(2):376-88 [11208829] N Engl J Med. 2001 Jul 26;345(4):241-7 [11474661] Clin Cancer Res. 2001 Dec;7(12):3862-8 [11751476] Clin Cancer Res. 2002 Oct;8(10):3092-9 [12374676] Int J Hematol. 2003 Jan;77(1):3-14 [12568294] J Clin Oncol. 2003 Apr 1;21(7):1278-84 [12663715] Transplantation. 2003 Sep 15;76(5):877-81 [14501873] Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):16-8 [14734446] Bone Marrow Transplant. 2004 May;33(9):881-9 [14990986] J Immunol. 2004 Jun 1;172(11):6658-65 [15153481] Lancet. 1972 Nov 18;2(7786):1067-9 [4117384] Proc Natl Acad Sci U S A. 1978 Oct;75(10):5011-4 [311004] J Clin Oncol. 1984 Dec;2(12):1336-42 [6334721] N Engl J Med. 1987 Mar 5;316(10):589-96 [3807953] Annu Rev Immunol. 1993;11:331-60 [8476565] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/1078-0432.CCR-11-0493 ER - TY - JOUR T1 - Activating PKC-β1 at the blood-brain barrier reverses induction of P-glycoprotein activity by dioxin and restores drug delivery to the CNS. AN - 869796474; 21487415 AB - Upregulation of blood-brain barrier (BBB) P-glycoprotein expression causes central nervous system (CNS) pharmacoresistance. However, activation of BBB protein kinase C-β1 (PKC-β1) rapidly reduces basal P-glycoprotein transport activity. We tested whether PKC-β1 activation would reverse CNS drug resistance caused by dioxin acting through aryl hydrocarbon receptor. A selective PKC-β1 agonist abolished the increase in P-glycoprotein activity induced by dioxin in isolated rat brain capillaries and reversed the effect of dioxin on brain uptake of verapamil in dioxin-dosed rats. Thus, targeting BBB PKC-β1 may be an effective strategy to improve drug delivery to the brain, even in drug-resistant individuals. JF - Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism AU - Wang, Xueqian AU - Hawkins, Brian T AU - Miller, David S AD - Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 1371 EP - 1375 VL - 31 IS - 6 KW - Anti-Arrhythmia Agents KW - 0 KW - Environmental Pollutants KW - P-Glycoprotein KW - Polychlorinated Dibenzodioxins KW - Verapamil KW - CJ0O37KU29 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Protein Kinase C beta KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Enzyme Activation KW - Verapamil -- pharmacokinetics KW - Anti-Arrhythmia Agents -- pharmacokinetics KW - Male KW - Protein Kinase C -- metabolism KW - Blood-Brain Barrier -- drug effects KW - Environmental Pollutants -- pharmacology KW - P-Glycoprotein -- metabolism KW - Brain -- drug effects KW - Brain -- blood supply KW - Polychlorinated Dibenzodioxins -- pharmacology KW - Blood-Brain Barrier -- metabolism KW - Brain -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869796474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cerebral+blood+flow+and+metabolism+%3A+official+journal+of+the+International+Society+of+Cerebral+Blood+Flow+and+Metabolism&rft.atitle=Activating+PKC-%CE%B21+at+the+blood-brain+barrier+reverses+induction+of+P-glycoprotein+activity+by+dioxin+and+restores+drug+delivery+to+the+CNS.&rft.au=Wang%2C+Xueqian%3BHawkins%2C+Brian+T%3BMiller%2C+David+S&rft.aulast=Wang&rft.aufirst=Xueqian&rft.date=2011-06-01&rft.volume=31&rft.issue=6&rft.spage=1371&rft.isbn=&rft.btitle=&rft.title=Journal+of+cerebral+blood+flow+and+metabolism+%3A+official+journal+of+the+International+Society+of+Cerebral+Blood+Flow+and+Metabolism&rft.issn=1559-7016&rft_id=info:doi/10.1038%2Fjcbfm.2011.44 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-23 N1 - Date created - 2011-06-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Pharmacol. 2010 Sep;78(3):376-83 [20547735] J Cereb Blood Flow Metab. 2010 Jul;30(7):1373-83 [20197783] Biochim Biophys Acta. 2003 Feb 17;1619(3):235-8 [12573482] Methods Mol Med. 2003;89:209-18 [12958422] Mol Pharmacol. 2004 Sep;66(3):387-94 [15322229] Mol Pharmacol. 2004 Sep;66(3):413-9 [15322232] Am J Physiol. 1995 Jan;268(1 Pt 2):F46-52 [7840247] Mol Pharmacol. 2006 Feb;69(2):462-70 [16278373] Diabetologia. 2007 Jan;50(1):202-11 [17143608] Pharm Res. 2007 Sep;24(9):1733-44 [17554607] J Cereb Blood Flow Metab. 2008 Jun;28(6):1222-34 [18349876] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Oct;27(4):197-211 [19953395] J Neurosci. 2010 Jan 27;30(4):1417-25 [20107068] Trends Pharmacol Sci. 2010 Jun;31(6):246-54 [20417575] FASEB J. 2011 Feb;25(2):644-52 [21048045] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/jcbfm.2011.44 ER - TY - JOUR T1 - Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. AN - 869793252; 21245015 AB - Mechanisms whereby gene-environment interactions mediate chronic, progressive neurodegenerative processes in Parkinson's disease (PD)-the second most common neurodegenerative disease-remain elusive. We created a two-hit [neuroinflammation and mutant α-synuclein (α-syn) overexpression] animal model to investigate mechanisms through which mutant α-syn and inflammation work in concert to mediate chronic PD neurodegeneration. We used an intraperitoneal injection of the inflammogen lipopolysaccharide (LPS; 3 × 106 EU/kg) to initiate systemic and brain inflammation in wild-type (WT) mice and transgenic (Tg) mice overexpressing human A53T mutant α-syn. We then evaluated nigral dopaminergic neurodegeneration, α-syn pathology, and neuroinflammation. After LPS injection, both WT and Tg mice initially displayed indistinguishable acute neuroinflammation; however, only Tg mice developed persistent neuroinflammation, chronic progressive degeneration of the nigrostriatal dopamine pathway, accumulation of aggregated, nitrated α-syn, and formation of Lewy body-like inclusions in nigral neurons. Further mechanistic studies indicated that 4-week infusion of two inhibitors of inducible nitric oxide synthase and NADPH oxidase, major free radical-generating enzymes in activated microglia, blocked nigral α-syn pathology and neurodegeneration in LPS-injected Tg mice. Microglia-derived oxidative stress bridged neuroinflammation and α-syn pathogenic alteration in mediating chronic PD progression. Our two-hit animal model involving both a genetic lesion and an environmental trigger reproduced key features of PD and demonstrated synergistic effects of genetic predisposition and environmental exposures in the development of PD. The chronic progressive nature of dopaminergic neurodegeneration, which is absent in most existing PD models, makes this new model invaluable for the study of mechanisms of PD progression. JF - Environmental health perspectives AU - Gao, Hui-Ming AU - Zhang, Feng AU - Zhou, Hui AU - Kam, Wayneho AU - Wilson, Belinda AU - Hong, Jau-Shyong AD - Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. gao2@niehs.nih.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 807 EP - 814 VL - 119 IS - 6 KW - Amidines KW - 0 KW - Benzylamines KW - Lipopolysaccharides KW - N-(3-(aminomethyl)benzyl)acetamidine KW - Onium Compounds KW - alpha-Synuclein KW - diphenyleneiodonium KW - 6HJ411TU98 KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Index Medicus KW - Injections, Intraperitoneal KW - Benzylamines -- pharmacology KW - Onium Compounds -- pharmacology KW - Animals KW - Amidines -- pharmacology KW - Lipopolysaccharides -- immunology KW - Lipopolysaccharides -- pharmacology KW - Oxidative Stress KW - Disease Models, Animal KW - Mice KW - Animals, Genetically Modified KW - Lewy Bodies -- pathology KW - Neurodegenerative Diseases -- chemically induced KW - alpha-Synuclein -- metabolism KW - Nerve Degeneration -- immunology KW - NADPH Oxidase -- antagonists & inhibitors KW - Neurodegenerative Diseases -- immunology KW - Nerve Degeneration -- chemically induced KW - Neurodegenerative Diseases -- pathology KW - Substantia Nigra -- immunology KW - alpha-Synuclein -- genetics KW - Parkinson Disease -- genetics KW - Parkinson Disease -- pathology KW - Neurodegenerative Diseases -- genetics KW - Parkinson Disease -- immunology KW - Substantia Nigra -- pathology KW - Nitric Oxide Synthase Type II -- antagonists & inhibitors KW - Nerve Degeneration -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869793252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Neuroinflammation+and+%CE%B1-synuclein+dysfunction+potentiate+each+other%2C+driving+chronic+progression+of+neurodegeneration+in+a+mouse+model+of+Parkinson%27s+disease.&rft.au=Gao%2C+Hui-Ming%3BZhang%2C+Feng%3BZhou%2C+Hui%3BKam%2C+Wayneho%3BWilson%2C+Belinda%3BHong%2C+Jau-Shyong&rft.aulast=Gao&rft.aufirst=Hui-Ming&rft.date=2011-06-01&rft.volume=119&rft.issue=6&rft.spage=807&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1003013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-28 N1 - Date created - 2011-06-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuron. 2002 May 16;34(4):521-33 [12062037] J Neurosci. 2000 Aug 15;20(16):6309-16 [10934283] Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8968-73 [12084935] Adv Neurol. 2003;91:133-42 [12442672] Neurosci Lett. 2003 May 1;341(2):87-90 [12686372] J Neurosci. 2003 Apr 15;23(8):3095-9 [12716914] Proc Natl Acad Sci U S A. 2003 May 13;100(10):6145-50 [12721370] Trends Pharmacol Sci. 2003 Aug;24(8):395-401 [12915048] Science. 2003 Oct 31;302(5646):841 [14593171] FASEB J. 2004 Mar;18(3):589-91 [14734632] Lancet. 2004 Sep 25-Oct 1;364(9440):1167-9 [15451224] Lancet. 2004 Sep 25-Oct 1;364(9440):1169-71 [15451225] Ann Neurol. 2004 Oct;56(4):591-5 [15455394] Neurology. 1988 Aug;38(8):1217-9 [3399070] Neurology. 1988 Aug;38(8):1285-91 [3399080] Science. 1997 Jun 27;276(5321):2045-7 [9197268] Nature. 1997 Aug 28;388(6645):839-40 [9278044] Nat Genet. 1998 Feb;18(2):106-8 [9462735] Ann Neurol. 1998 Sep;44(3 Suppl 1):S72-84 [9749577] FASEB J. 2005 Apr;19(6):533-42 [15791003] Nat Rev Genet. 2006 Apr;7(4):306-18 [16543934] Neurobiol Aging. 2006 Jun;27(6):848-56 [16006012] Exp Neurol. 2006 Jun;199(2):499-512 [16504177] Science. 2006 Jul 21;313(5785):324-8 [16794039] Neurobiol Dis. 2007 Jan;25(1):134-49 [17055279] Nat Rev Neurosci. 2007 Jan;8(1):57-69 [17180163] Am J Pathol. 2007 Feb;170(2):658-66 [17255333] Glia. 2007 Apr 1;55(5):453-62 [17203472] Arch Neurol. 2007 Jun;64(6):836-40 [17562931] Nat Med. 2008 May;14(5):507-9 [18391961] Nat Med. 2008 May;14(5):504-6 [18391962] Nat Med. 2008 May;14(5):501-3 [18391963] J Neurosci. 2008 Jul 23;28(30):7687-98 [18650345] Trends Immunol. 2008 Aug;29(8):357-65 [18599350] J Neurosci. 2008 Oct 22;28(43):10825-34 [18945890] J Neurosci. 2009 Feb 4;29(5):1480-5 [19193894] Lancet Neurol. 2009 Apr;8(4):382-97 [19296921] Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13010-5 [19651612] Ann Neurol. 2009 Oct;66(4):494-504 [19847896] Neuron. 2010 Jun 10;66(5):646-61 [20547124] Nat Genet. 2010 Sep;42(9):781-5 [20711177] Nat Med. 1999 Dec;5(12):1403-9 [10581083] Science. 2000 Feb 18;287(5456):1265-9 [10678833] J Neurochem. 2002 Jun;81(6):1285-97 [12068076] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.1003013 ER - TY - JOUR T1 - Estimating the global public health implications of electricity and coal consumption. AN - 869793098; 21339091 AB - The growing health risks associated with greenhouse gas emissions highlight the need for new energy policies that emphasize efficiency and low-carbon energy intensity. We assessed the relationships among electricity use, coal consumption, and health outcomes. Using time-series data sets from 41 countries with varying development trajectories between 1965 and 2005, we developed an autoregressive model of life expectancy (LE) and infant mortality (IM) based on electricity consumption, coal consumption, and previous year's LE or IM. Prediction of health impacts from the Greenhouse Gas and Air Pollution Interactions and Synergies (GAINS) integrated air pollution emissions health impact model for coal-fired power plants was compared with the time-series model results. The time-series model predicted that increased electricity consumption was associated with reduced IM for countries that started with relatively high IM (> 100/1,000 live births) and low LE (< 57 years) in 1965, whereas LE was not significantly associated with electricity consumption regardless of IM and LE in 1965. Increasing coal consumption was associated with increased IM and reduced LE after accounting for electricity consumption. These results are consistent with results based on the GAINS model and previously published estimates of disease burdens attributable to energy-related environmental factors, including indoor and outdoor air pollution and water and sanitation. Increased electricity consumption in countries with IM < 100/1,000 live births does not lead to greater health benefits, whereas coal consumption has significant detrimental health impacts. JF - Environmental health perspectives AU - Gohlke, Julia M AU - Thomas, Reuben AU - Woodward, Alistair AU - Campbell-Lendrum, Diarmid AU - Prüss-Üstün, Annette AU - Hales, Simon AU - Portier, Christopher J AD - Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. jgohlke@uab.edu Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 821 EP - 826 VL - 119 IS - 6 KW - Coal KW - 0 KW - Index Medicus KW - Infant KW - Air Pollution KW - Greenhouse Effect KW - Humans KW - Life Expectancy KW - Infant Mortality KW - Public Health -- trends KW - Models, Biological KW - Risk Assessment KW - Coal -- adverse effects KW - Electric Power Supplies -- adverse effects KW - Coal -- utilization KW - Electric Power Supplies -- utilization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869793098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Estimating+the+global+public+health+implications+of+electricity+and+coal+consumption.&rft.au=Gohlke%2C+Julia+M%3BThomas%2C+Reuben%3BWoodward%2C+Alistair%3BCampbell-Lendrum%2C+Diarmid%3BPr%C3%BCss-%C3%9Cst%C3%BCn%2C+Annette%3BHales%2C+Simon%3BPortier%2C+Christopher+J&rft.aulast=Gohlke&rft.aufirst=Julia&rft.date=2011-06-01&rft.volume=119&rft.issue=6&rft.spage=821&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1002241 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-28 N1 - Date created - 2011-06-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Sci Total Environ. 2004 Sep 1;330(1-3):71-80 [15325159] J Health Popul Nutr. 2004 Mar;22(1):27-33 [15190809] Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 1):669-74 [7881654] J Toxicol Environ Health A. 2005 Jul 9-23;68(13-14):1301-7 [16024504] Ann N Y Acad Sci. 2006 Sep;1076:516-26 [17119229] J Toxicol Environ Health A. 2007 Feb 1;70(3-4):316-31 [17365594] Lancet. 2007 Sep 15;370(9591):965-78 [17876909] Lancet. 2007 Sep 15;370(9591):979-90 [17876910] Lancet. 2007 Oct 6;370(9594):1264-81 [17868819] Annu Rev Public Health. 2008;29:11-25 [18173381] Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):11884-8 [19581586] Lancet. 2009 Dec 12;374(9706):2006-15 [19942282] Lancet. 2009 Dec 19;374(9707):2104-14 [19942281] Occup Environ Med. 2004 Nov;61(11):893-8 [15477282] Educ Health (Abingdon). 2003 Jul;16(2):230 [14741909] Public Health Rep. 2001 Sep-Oct;116(5):474-83 [12042611] Bull World Health Organ. 2002;80(5):391-8 [12077615] Comment In: Environ Health Perspect. 2011 Jun;119(6):A258 [21628111] Erratum In: Environ Health Perspect. 2014 Nov;122(11):A295 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.1002241 ER - TY - JOUR T1 - Association of Serum Sex Steroid Hormone Hemodilution and Body Mass Index Among Healthy Postmenopausal Women AN - 869582046; 14819678 AB - Purpose: Hemodilution refers to reduced concentrations of analytes in the blood secondary to increased fluid volume. Given that obesity is associated with expanded vascular volume, hemodilution may result in a lower ratio of blood concentrations of analytes among heavier subjects. Assessing the relationship of hormone concentration to total mass varies by body mass index (BMI) is etiologically important because obesity is related to hormone metabolism and cancer risk. Methods: We evaluated data for 194 postmenopausal controls in an endometrial cancer case-control study. Height, weight, and serum hormone concentrations were measured previously. We estimated serum hormone mass from concentration based on estimates of calculated plasma volume. We assessed the effect ofI on relationships of sex steroid hormone concentration and mass using multivariate linear regression. Results: HigherI was associated with increased estrone, estrone sulfate, estradiol, and albumin-bound estradiol concentrations and masses (p-trend <= 0.001). With increasingI, androstenedione concentration did not change significantly (p-trend = 0.548), but its mass increased (p-trend = 0.024). Conclusions: Relationships of sex steroid hormone concentration and mass were generally similar, except for androstenedione in which the relationship was only significant for mass. Future studies to assess both sex steroid hormone concentration and mass may have value in etiological research. JF - Annals of Epidemiology AU - Yang, Hannah P AU - Black, Amanda AU - Falk, Roni T AU - Brinton, Louise A AU - Potischman, Nancy AU - Wentzensen, Nicolas AU - Faupel-Badger, Jessica M AU - Sherman, Mark E AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, yanghan@mail.nih.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 466 EP - 471 PB - Elsevier Science, Box 882 New York NY 10159 USA VL - 21 IS - 6 SN - 1047-2797, 1047-2797 KW - Physical Education Index; Risk Abstracts; Health & Safety Science Abstracts KW - Blood KW - Body mass KW - Cancer KW - Females KW - Height KW - Hormones KW - Metabolism KW - Obesity KW - Sex KW - Steroids KW - Sulfates KW - Women KW - body mass KW - obesity KW - post-menopause KW - steroid hormones KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869582046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Association+of+Serum+Sex+Steroid+Hormone+Hemodilution+and+Body+Mass+Index+Among+Healthy+Postmenopausal+Women&rft.au=Yang%2C+Hannah+P%3BBlack%2C+Amanda%3BFalk%2C+Roni+T%3BBrinton%2C+Louise+A%3BPotischman%2C+Nancy%3BWentzensen%2C+Nicolas%3BFaupel-Badger%2C+Jessica+M%3BSherman%2C+Mark+E&rft.aulast=Yang&rft.aufirst=Hannah&rft.date=2011-06-01&rft.volume=21&rft.issue=6&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2011.01.003 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Obesity; Blood; Body mass; Women; Height; Steroids; Hormones; Cancer; Sex; Sulfates; post-menopause; body mass; obesity; steroid hormones; Females; Metabolism DO - http://dx.doi.org/10.1016/j.annepidem.2011.01.003 ER - TY - JOUR T1 - Rapid detection of ABC transporter interaction: Potential utility in pharmacology AN - 869579136; 14767890 AB - Introduction: The ATP-binding cassette (ABC) transporters P-glycoprotein (P-gp/ABCB1), multidrug resistance-associated protein 1 (MRP1/ABCC1), and breast cancer resistance protein (BCRP/ABCG2) are known to transport a wide range of structurally diverse compounds. Their high level of expression at the blood-brain, maternal-fetal, and blood-testis barriers as well as their purported roles in oral absorption suggests that ABC transporters play important pharmacologic roles. Methods: We have developed a method to characterize the function and inhibition of ABC transporters using an automated cell counter with fluorescence detection capability. The assay was performed using stably-transfected HEK293 cells expressing P-gp, MRP1, or ABCG2 and examining transport of fluorescent substrates in the presence or absence of known inhibitors and compared to results obtained with a flow cytometer. Fold increase in intracellular fluorescence was then calculated for cells incubated with fluorescent substrate in the absence of inhibitor versus in the presence of inhibitor. Results: Fold increase values obtained either with the cell counter or flow cytometer were comparable for cells expressing either MRP1 or ABCG2; slightly higher fold increase values were observed when cells expressing P-gp were read on a flow cytometer compared to the cell counter. Discussion: The assay described provides an inexpensive detection method to aid in the development of novel ABC transporter inhibitors or to characterize potential drug-drug interactions. JF - Journal of Pharmacological and Toxicological Methods AU - Robey, Robert W AU - Lin, Bo AU - Qiu, Jean AU - Chan, Leo Li-Ying AU - Bates, Susan E AD - Medical Oncology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, United States, robeyr@mail.nih.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 217 EP - 222 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 63 IS - 3 SN - 1056-8719, 1056-8719 KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Fluorescence KW - ABC transporter KW - Pharmacology KW - Cancer KW - cell counters KW - P-Glycoprotein KW - Absorption KW - MRP protein KW - Proteins KW - Breast cancer KW - drug interaction KW - X 24310:Pharmaceuticals KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869579136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmacological+and+Toxicological+Methods&rft.atitle=Rapid+detection+of+ABC+transporter+interaction%3A+Potential+utility+in+pharmacology&rft.au=Robey%2C+Robert+W%3BLin%2C+Bo%3BQiu%2C+Jean%3BChan%2C+Leo+Li-Ying%3BBates%2C+Susan+E&rft.aulast=Robey&rft.aufirst=Robert&rft.date=2011-06-01&rft.volume=63&rft.issue=3&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmacological+and+Toxicological+Methods&rft.issn=10568719&rft_id=info:doi/10.1016%2Fj.vascn.2010.11.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - P-Glycoprotein; Fluorescence; Pharmacology; ABC transporter; MRP protein; Breast cancer; cell counters; Absorption; Proteins; Cancer; drug interaction DO - http://dx.doi.org/10.1016/j.vascn.2010.11.003 ER - TY - JOUR T1 - Recombinant immunotoxins and other therapies for relapsed/refractory hairy cell leukemia. AN - 868998765; 21599609 AB - Standard treatment for hairy cell leukemia (HCL) is markedly effective, but the constant decrease in disease-free survival, together with the presence of minimal residual disease (MRD), suggests that few if any are cured. HCL cells in MRD are always strongly CD20 + and CD22 + , and also CD25 + unless the patient has the poor-prognosis variant HCLv. To target relapsed/refractory HCL, immunotherapy has been developed using anti-CD25 and anti-CD22 recombinant immunotoxins, or the anti-CD20 monoclonal antibody (mAb) rituximab alone or combined with purine analogs. The recombinant immunotoxins contain an Fv fragment of a mAb fused to a truncated form of Pseudomonas exotoxin called PE38. BL22 targeting CD22, in phase I and II testing of relapsed/refractory HCL, achieved 47-61% complete remissions (CRs), several of them ongoing after 9-10 years. A completely reversible form of hemolytic uremic syndrome (HUS) was observed in 12% of patients, several of whom could later achieve a partial remission (PR) or CR with LMB-2 targeting CD25. A higher-affinity version of BL22, termed HA22, CAT-8015, or moxetumomab pasudotox, developed to more effectively treat other hematologic malignancies, also achieves CRs in HCL, and with only non-dose-limiting HUS. In separate randomized trials, rituximab is undergoing phase II testing with cladribine for early HCL and with bendamustine or pentostatin for multiply relapsed HCL. JF - Leukemia & lymphoma AU - Kreitman, Robert J AU - Arons, Evgeny AU - Stetler-Stevenson, Maryalice AU - Fitzgerald, David J P AU - Wilson, Wyndham H AU - Pastan, Ira AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. kreitmar@mail.nih.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 82 EP - 86 VL - 52 Suppl 2 KW - Immunotoxins KW - 0 KW - Index Medicus KW - Humans KW - Clinical Trials as Topic KW - Salvage Therapy -- methods KW - Leukemia, Hairy Cell -- drug therapy KW - Immunotoxins -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/868998765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia+%26+lymphoma&rft.atitle=Recombinant+immunotoxins+and+other+therapies+for+relapsed%2Frefractory+hairy+cell+leukemia.&rft.au=Kreitman%2C+Robert+J%3BArons%2C+Evgeny%3BStetler-Stevenson%2C+Maryalice%3BFitzgerald%2C+David+J+P%3BWilson%2C+Wyndham+H%3BPastan%2C+Ira&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2011-06-01&rft.volume=52+Suppl+2&rft.issue=&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Leukemia+%26+lymphoma&rft.issn=1029-2403&rft_id=info:doi/10.3109%2F10428194.2011.565843 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-29 N1 - Date created - 2011-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/10428194.2011.565843 ER - TY - JOUR T1 - Enhancing immunotoxin cell-killing activity via combination therapy with ABT-737. AN - 868998763; 21599608 AB - Immunotoxins are antibody-toxin fusion proteins directed to kill cancer cells displaying specific target antigens on their surface. Remarkably, immunotoxins directed to CD22 on hairy cell leukemia have produced complete remissions in approximately 60% of patients enrolled in phase I/II trials. For reasons that are not yet clear, 40% of patients responded less well. In addition, patients with other CD22-positive malignancies have not yet achieved complete remissions. In trying to understand 'resistance' to immunotoxin therapy, a number of challenging issues have been raised. These include insufficient dosing, the production of neutralizing anti-immunotoxin antibodies, poor access to malignant cells, and resistance to toxin killing. In designing immunotoxins, we employ truncated Pseudomonas exotoxin, which enzymatically inactivates protein synthesis and produces cell death in sensitive cells. To begin to address toxin resistance we have explored combination therapy with the BH3-only mimetic, ABT-737. Our results indicate that immunotoxin-ABT combinations often exhibit greater killing activity than either compound alone and in some instances overcome resistance. Expression of high levels of prosurvival Bcl-2 proteins may contribute to toxin resistance. JF - Leukemia & lymphoma AU - Fitzgerald, David J AU - Moskatel, Elizabeth AU - Ben-Josef, Gal AU - Traini, Roberta AU - Tendler, Tara AU - Sharma, Ashima AU - Antignani, Antonella AU - Mussai, Francis AU - Wayne, Alan AU - Kreitman, Robert J AU - Pastan, Ira AD - Laboratory of Molecular Biology, CCR, National Cancer Institute, NIH, HHS, Bethesda, MD, USA. djpf@helix.nih.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 79 EP - 81 VL - 52 Suppl 2 KW - ABT-737 KW - 0 KW - Biphenyl Compounds KW - CD22 protein, human KW - Immunotoxins KW - Nitrophenols KW - Piperazines KW - Sialic Acid Binding Ig-like Lectin 2 KW - Sulfonamides KW - Index Medicus KW - Sialic Acid Binding Ig-like Lectin 2 -- immunology KW - Biphenyl Compounds -- therapeutic use KW - Piperazines -- therapeutic use KW - Humans KW - Nitrophenols -- therapeutic use KW - Immunotoxins -- therapeutic use KW - Drug Synergism KW - Sulfonamides -- therapeutic use KW - Leukemia, Hairy Cell -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/868998763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia+%26+lymphoma&rft.atitle=Enhancing+immunotoxin+cell-killing+activity+via+combination+therapy+with+ABT-737.&rft.au=Fitzgerald%2C+David+J%3BMoskatel%2C+Elizabeth%3BBen-Josef%2C+Gal%3BTraini%2C+Roberta%3BTendler%2C+Tara%3BSharma%2C+Ashima%3BAntignani%2C+Antonella%3BMussai%2C+Francis%3BWayne%2C+Alan%3BKreitman%2C+Robert+J%3BPastan%2C+Ira&rft.aulast=Fitzgerald&rft.aufirst=David&rft.date=2011-06-01&rft.volume=52+Suppl+2&rft.issue=&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Leukemia+%26+lymphoma&rft.issn=1029-2403&rft_id=info:doi/10.3109%2F10428194.2011.569961 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-29 N1 - Date created - 2011-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/10428194.2011.569961 ER - TY - JOUR T1 - Immunotoxins with decreased immunogenicity and improved activity. AN - 868998002; 21504287 AB - Recombinant immunotoxins, containing an Fv fragment and a bacterial toxin, frequently elicit neutralizing antibodies, nearly always against the toxin. Moxetumomab pasudotox (previously called CAT-8015 or HA22) contains an anti-CD22 Fv fused to PE38, a truncated form of Pseudomonas exotoxin, containing amino acids 253-364 and 381-613. One avenue to reducing immunogenicity is to identify B- and T-cell epitopes and remove them while retaining toxin activity. To determine B-cell epitopes on PE38, 60 monoclonal antibodies against PE38 were tested in a pairwise manner, and seven major epitope groups with 13 subgroups were identified. The locations of many of these epitopes were identified by mutating large surface-exposed residues to alanine. A mutant of moxetumomab pasudotox containing eight epitope-eliminating mutations (HA22-8X) was prepared, and greatly reduced immunogenicity in mice. In parallel, two large sections of PE38 containing lysosomal protease cleavage sites were removed, leaving only amino acids 274-284 and 394-613 of the toxin. The resulting molecule, HA22-LR, retained cytotoxicity toward CD22+ cell lines, killed primary chronic lymphocytic leukemia cells more potently than moxetumomab pasudotox, was much less toxic to mice, and had significantly improved antitumor activity toward murine xenografts. The immunogenicity and activity of recombinant immunotoxins may be optimized by combinations of these approaches. JF - Leukemia & lymphoma AU - Pastan, Ira AU - Onda, Masanori AU - Weldon, John AU - Fitzgerald, David AU - Kreitman, Robert AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 87 EP - 90 VL - 52 Suppl 2 KW - Epitopes, B-Lymphocyte KW - 0 KW - Immunotoxins KW - Index Medicus KW - Animals KW - Humans KW - Mice KW - Mutation KW - Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy KW - Immunotoxins -- immunology KW - Leukemia, Lymphocytic, Chronic, B-Cell -- immunology KW - Immunotoxins -- therapeutic use KW - Immunotoxins -- pharmacology KW - Epitopes, B-Lymphocyte -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/868998002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia+%26+lymphoma&rft.atitle=Immunotoxins+with+decreased+immunogenicity+and+improved+activity.&rft.au=Pastan%2C+Ira%3BOnda%2C+Masanori%3BWeldon%2C+John%3BFitzgerald%2C+David%3BKreitman%2C+Robert&rft.aulast=Pastan&rft.aufirst=Ira&rft.date=2011-06-01&rft.volume=52+Suppl+2&rft.issue=&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Leukemia+%26+lymphoma&rft.issn=1029-2403&rft_id=info:doi/10.3109%2F10428194.2011.573039 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-29 N1 - Date created - 2011-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/10428194.2011.573039 ER - TY - JOUR T1 - Long-term results of a randomized trial on the sequencing of radiotherapy and chemotherapy in breast cancer. AN - 868766743; 20805741 AB - A prospective, phase III randomized study was undertaken to compare the outcomes of 2 different radiotherapy and chemotherapy sequences in conservatively treated patients with breast cancer. Between January 1997 and November 2002, 206 patients operated of quadrantectomy and axillary dissection for breast cancer, candidates to receive adjuvant CMF chemotherapy (cyclophosphamide, methotrexate, and fluorouracil) were assigned to concurrent or sequential radiation treatment by using a balanced randomization method. Before randomization patients were stratified by tumor diameter, age, and lymph node status. The primary end point was the freedom from breast recurrence, and secondary end points were overall and disease-free survival. Overall outcomes were analyzed according to the intention-to-treat principle. All 206 patients enrolled and randomized in the trial were analyzed. The median follow-up was 111 months, with no patient lost for follow-up. No difference in 10-years breast recurrence-free, disease-free, metastasis-free, and overall survival rates was observed in the 2 treatment sequence groups. The Hazard Ratios, calculated for each prognostic factor, showed no difference in all outcomes between the 2 treatment sequences. No influence of the treatment sequence on long-term outcomes was observed in this trial. This finding suggests that to avoid an increased risk of distant recurrence or an excessive toxicity, radiation therapy may be delayed until after the end of the more, recently used, anthracycline-based chemotherapy without increasing the risk of breast recurrences, thus allowing the delivery of full-dose chemotherapy in patients at risk for systemic disease spread. JF - American journal of clinical oncology AU - Pinnarò, Paola AU - Rambone, Rita AU - Giordano, Carolina AU - Giannarelli, Diana AU - Strigari, Lidia AU - Arcangeli, Giorgio AD - Department of Radiotherapy, Regina Elena National Cancer Institute, Rome, Italy. Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 238 EP - 244 VL - 34 IS - 3 KW - Cyclophosphamide KW - 8N3DW7272P KW - Fluorouracil KW - U3P01618RT KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Disease-Free Survival KW - Drug Administration Schedule KW - Humans KW - Prognosis KW - Aged KW - Predictive Value of Tests KW - Recurrence KW - Risk Assessment KW - Fluorouracil -- administration & dosage KW - Prospective Studies KW - Risk Factors KW - Adult KW - Treatment Outcome KW - Follow-Up Studies KW - Middle Aged KW - Time Factors KW - Methotrexate -- administration & dosage KW - Female KW - Survival Analysis KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - Chemotherapy, Adjuvant -- methods KW - Radiotherapy, Adjuvant -- methods KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Breast Neoplasms -- surgery KW - Breast Neoplasms -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/868766743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+clinical+oncology&rft.atitle=Long-term+results+of+a+randomized+trial+on+the+sequencing+of+radiotherapy+and+chemotherapy+in+breast+cancer.&rft.au=Pinnar%C3%B2%2C+Paola%3BRambone%2C+Rita%3BGiordano%2C+Carolina%3BGiannarelli%2C+Diana%3BStrigari%2C+Lidia%3BArcangeli%2C+Giorgio&rft.aulast=Pinnar%C3%B2&rft.aufirst=Paola&rft.date=2011-06-01&rft.volume=34&rft.issue=3&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=American+journal+of+clinical+oncology&rft.issn=1537-453X&rft_id=info:doi/10.1097%2FCOC.0b013e3181dea9b8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-21 N1 - Date created - 2011-05-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/COC.0b013e3181dea9b8 ER - TY - JOUR T1 - Non-enrollment for free community HIV care: findings from a population-based study in Rakai, Uganda AN - 868764378; 4198529 AB - Improved understanding of HIV-related health-seeking behavior at a population level is important in informing the design of more effective HIV prevention and care strategies. We assessed the frequency and determinants of failure to seek free HIV care in Rakai, Uganda. HIV-positive participants in a community cohort who accepted VCT were referred for free HIV care (cotrimoxazole prophylaxis, CD4 monitoring, treatment of opportunistic infections, and, when indicated, antiretroviral therapy). We estimated proportion and adjusted Prevalence Risk Ratios (adj. PRR) of non-enrollment into care six months after receipt of VCT using log-binomial regression. About 1145 HIV-positive participants in the Rakai Community Cohort Study accepted VCT and were referred for care. However, 31.5% (361/1145) did not enroll into HIV care six months after referral. Non-enrollment was significantly higher among men (38%) compared to women (29%, p=0.005). Other factors associated with non-enrollment included: younger age (15-24 years, adj. PRR = 2.22; 95% CI: 1.64, 3.00), living alone (adj. PRR = 2.22; 95% CI: 1.57, 3.15); or in households with 1-2 co-residents (adj. PRR = 1.63; 95% CI: 1.31, 2.03) compared to three or more co-residents, or a CD4 count >250 cells/ul (adj. PRR = 1.81; 95% CI: 1.38, 2.46). Median (IQR) CD4 count was lower among enrolled 388 cells/ul (IQR: 211,589) compared to those not enrolled 509 cells/ul (IQR: 321,754). About one-third of HIV-positive persons failed to utilize community-based free services. Non-use of services was greatest among men, the young, persons with higher CD4 counts and the more socially isolated, suggesting a need for targeted strategies to enhance service uptake. Reprinted by permission of Routledge, Taylor & Francis Ltd. JF - AIDS care AU - Nakigozi, Gertrude AU - Makumbi, Fredrick AU - Reynolds, Steven AU - Galiwango, Ronald AU - Kagaayi, Joseph AU - Nalugoda, Fred AU - Ssettuba, Absalom AU - Sekasanvu, Joseph AU - Musuuza, Jackson AU - Serwada, David AU - Gray, Ron AU - Wawer, Maria AD - Rakai Health Sciences Program, Kalisizo ; Makerere University ; National Institutes of Health, Bethesda ; Johns Hopkins University Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 764 EP - 770 VL - 23 IS - 6 SN - 0954-0121, 0954-0121 KW - Sociology KW - Medical care KW - Health care KW - AIDS KW - Uganda KW - Community services KW - Medical treatment KW - HIV KW - Access to health care KW - Health services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/868764378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=Non-enrollment+for+free+community+HIV+care%3A+findings+from+a+population-based+study+in+Rakai%2C+Uganda&rft.au=Nakigozi%2C+Gertrude%3BMakumbi%2C+Fredrick%3BReynolds%2C+Steven%3BGaliwango%2C+Ronald%3BKagaayi%2C+Joseph%3BNalugoda%2C+Fred%3BSsettuba%2C+Absalom%3BSekasanvu%2C+Joseph%3BMusuuza%2C+Jackson%3BSerwada%2C+David%3BGray%2C+Ron%3BWawer%2C+Maria&rft.aulast=Nakigozi&rft.aufirst=Gertrude&rft.date=2011-06-01&rft.volume=23&rft.issue=6&rft.spage=764&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540121.2010.525614 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5703 3617 6220; 482 3617 6220; 5775 13521; 7875 5775 13521; 7890 5792 10484; 5792 10484; 516 5775 13521; 2618 10484; 435 115 2 DO - http://dx.doi.org/10.1080/09540121.2010.525614 ER - TY - JOUR T1 - Elvitegravir overcomes resistance to raltegravir induced by integrase mutation Y143. AN - 868030555; 21505303 AB - In this study, we characterized elvitegravir activity in the context of raltegravir resistance mutations. Using site-directed mutagenesis, we generated recombinant integrase proteins and viruses harboring raltegravir resistance mutation to assess the biochemical and cellular activity of elvitegravir in the presence of such mutants. Recombinant proteins were used in gel-based assays. Antiviral data were obtained with reporter viruses in a single-round infection using a luciferase-based assay. Although main raltegravir resistance pathways involving mutations at integrase position 148 and 155 confer cross-resistance to elvitegravir, elvitegravir remains fully active against the Y143R mutant integrase and virus particles. In addition to favorable pharmacokinetics compared to raltegravir, our findings provide the rationale for using elvitegravir in patients failing raltegravir because of the integrase mutation Y143. JF - AIDS (London, England) AU - Métifiot, Mathieu AU - Vandegraaff, Nick AU - Maddali, Kasthuraiah AU - Naumova, Alena AU - Zhang, Xuemin AU - Rhodes, David AU - Marchand, Christophe AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2011/06/01/ PY - 2011 DA - 2011 Jun 01 SP - 1175 EP - 1178 VL - 25 IS - 9 KW - DNA, Viral KW - 0 KW - HIV Integrase Inhibitors KW - JTK 303 KW - Pyrrolidinones KW - Quinolones KW - Raltegravir Potassium KW - 43Y000U234 KW - HIV Integrase KW - EC 2.7.7.- KW - Index Medicus KW - AIDS/HIV KW - Virus Replication -- genetics KW - Virus Replication -- drug effects KW - Humans KW - DNA, Viral -- drug effects KW - DNA, Viral -- genetics KW - Point Mutation -- genetics KW - HIV-1 -- genetics KW - Pyrrolidinones -- pharmacokinetics KW - HIV Integrase -- pharmacology KW - Drug Resistance, Viral -- drug effects KW - HIV Integrase Inhibitors -- pharmacokinetics KW - Quinolones -- pharmacokinetics KW - Drug Resistance, Viral -- genetics KW - HIV Integrase -- genetics KW - HIV Integrase Inhibitors -- pharmacology KW - HIV-1 -- drug effects KW - Pyrrolidinones -- pharmacology KW - Quinolones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/868030555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Elvitegravir+overcomes+resistance+to+raltegravir+induced+by+integrase+mutation+Y143.&rft.au=M%C3%A9tifiot%2C+Mathieu%3BVandegraaff%2C+Nick%3BMaddali%2C+Kasthuraiah%3BNaumova%2C+Alena%3BZhang%2C+Xuemin%3BRhodes%2C+David%3BMarchand%2C+Christophe%3BPommier%2C+Yves&rft.aulast=M%C3%A9tifiot&rft.aufirst=Mathieu&rft.date=2011-06-01&rft.volume=25&rft.issue=9&rft.spage=1175&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=1473-5571&rft_id=info:doi/10.1097%2FQAD.0b013e3283473599 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-13 N1 - Date created - 2011-05-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/QAD.0b013e3283473599 ER - TY - JOUR T1 - Gene-environment interactions: key to unraveling the mystery of Parkinson's disease. AN - 867325085; 21439347 AB - Parkinson's disease (PD) is the second most common neurodegenerative disease. The gradual, irreversible loss of dopamine neurons in the substantia nigra is the signature lesion of PD. Clinical symptoms of PD become apparent when 50-60% of nigral dopamine neurons are lost. PD progresses insidiously for 5-7 years (preclinical period) and then continues to worsen even under the symptomatic treatment. To determine what triggers the disease onset and what drives the chronic, self-propelling neurodegenerative process becomes critical and urgent, since lack of such knowledge impedes the discovery of effective treatments to retard PD progression. At present, available therapeutics only temporarily relieve PD symptoms. While the identification of causative gene defects in familial PD uncovers important genetic influences in this disease, the majority of PD cases are sporadic and idiopathic. The current consensus suggests that PD develops from multiple risk factors including aging, genetic predisposition, and environmental exposure. Here, we briefly review research on the genetic and environmental causes of PD. We also summarize very recent genome-wide association studies on risk gene polymorphisms in the emergence of PD. We highlight the new converging evidence on gene-environment interplay in the development of PD with an emphasis on newly developed multiple-hit PD models involving both genetic lesions and environmental triggers. Published by Elsevier Ltd. JF - Progress in neurobiology AU - Gao, Hui-Ming AU - Hong, Jau-Shyong AD - Neuropharmacology Section, Laboratory of Toxicology & Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. gao2@niehs.nih.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 1 EP - 19 VL - 94 IS - 1 KW - Index Medicus KW - Animals KW - Humans KW - Disease Models, Animal KW - Parkinson Disease -- etiology KW - Environment KW - Genetic Predisposition to Disease KW - Parkinson Disease -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867325085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+neurobiology&rft.atitle=Gene-environment+interactions%3A+key+to+unraveling+the+mystery+of+Parkinson%27s+disease.&rft.au=Gao%2C+Hui-Ming%3BHong%2C+Jau-Shyong&rft.aulast=Gao&rft.aufirst=Hui-Ming&rft.date=2011-06-01&rft.volume=94&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Progress+in+neurobiology&rft.issn=1873-5118&rft_id=info:doi/10.1016%2Fj.pneurobio.2011.03.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-08 N1 - Date created - 2011-05-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lancet. 2008 Apr 26;371(9622):1464-75 [18440429] Mov Disord. 2008 Apr 30;23(6):881-5 [18307263] Nat Cell Biol. 2007 Nov;9(11):1243-52 [17906618] J Neurosci. 2007 Nov 7;27(45):12413-8 [17989306] Am J Epidemiol. 2008 Jan 1;167(1):90-5 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AN - 866532255; 21091656 AB - Pregnane X receptor (PXR) is a pivotal nuclear receptor modulating xenobiotic metabolism primarily through its regulation of CYP3A4, the most important enzyme involved in drug metabolism in humans. Due to the marked species differences in ligand recognition by PXR, PXR-humanized (hPXR) mice, and mice expressing human PXR and CYP3A4 (Tg3A4/hPXR) were established. hPXR and Tg3A4/hPXR mice are valuable models for investigating the role of PXR in xenobiotic metabolism and toxicity, in lipid, bile acid and steroid hormone homeostasis, and in the control of inflammation. British Journal of Pharmacology © 2011 The British Pharmacological Society. No claim to original US government works. JF - British journal of pharmacology AU - Cheng, Jie AU - Ma, Xiaochao AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 461 EP - 468 VL - 163 IS - 3 KW - Pharmaceutical Preparations KW - 0 KW - Receptors, Steroid KW - Xenobiotics KW - pregnane X receptor KW - CYP3A4 protein, human KW - EC 1.14.13.67 KW - Cytochrome P-450 CYP3A KW - EC 1.14.14.1 KW - Index Medicus KW - Animals KW - Drug-Related Side Effects and Adverse Reactions KW - Humans KW - Xenobiotics -- metabolism KW - Liver -- metabolism KW - Mice KW - Organ Specificity KW - Xenobiotics -- toxicity KW - Intestines -- metabolism KW - Mice, Transgenic KW - Mice, Knockout KW - Species Specificity KW - Inflammatory Bowel Diseases -- drug therapy KW - Pharmaceutical Preparations -- metabolism KW - Receptors, Steroid -- antagonists & inhibitors KW - Cytochrome P-450 CYP3A -- metabolism KW - Receptors, Steroid -- metabolism KW - Disease Models, Animal KW - Receptors, Steroid -- genetics KW - Cytochrome P-450 CYP3A -- genetics KW - Drug Evaluation, Preclinical -- methods KW - Receptors, Steroid -- agonists UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866532255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+pharmacology&rft.atitle=Pregnane+X+receptor-+and+CYP3A4-humanized+mouse+models+and+their+applications.&rft.au=Cheng%2C+Jie%3BMa%2C+Xiaochao%3BGonzalez%2C+Frank+J&rft.aulast=Cheng&rft.aufirst=Jie&rft.date=2011-06-01&rft.volume=163&rft.issue=3&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=British+journal+of+pharmacology&rft.issn=1476-5381&rft_id=info:doi/10.1111%2Fj.1476-5381.2010.01129.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-27 N1 - Date created - 2011-05-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drug Metab Dispos. 2008 Aug;36(8):1538-45 [18474680] Int J Cancer. 2010 Dec 15;127(12):2959-64 [21351274] J Clin Invest. 2008 Sep;118(9):3228-39 [18677425] Drug Metab Dispos. 2008 Dec;36(12):2506-12 [18799805] Pharmacogenet Genomics. 2009 Jan;19(1):11-24 [19077665] J Biol Chem. 2009 Mar 13;284(11):6639-49 [19141612] J Biol Chem. 2009 Apr 3;284(14):9199-205 [19144646] Drug Metab Dispos. 2009 Aug;37(8):1611-21 [19460945] Mol Pharmacol. 2009 Sep;76(3):604-11 [19542321] Biochemistry. 2009 Dec 8;48(48):11572-81 [19856963] Cancer Res. 2009 Dec 1;69(23):8996-9002 [19920203] PLoS Comput Biol. 2009 Dec;5(12):e1000594 [20011107] Biochem Biophys Res Commun. 2010 Mar 19;393(4):688-93 [20171174] J Biol Chem. 2010 Sep 3;285(36):28097-104 [20562110] J Pharmacol Exp Ther. 2010 Oct;335(1):32-41 [20627999] J Pharmacol Exp Ther. 2010 Nov;335(2):342-50 [20719936] Nature. 2000 Jul 27;406(6794):435-9 [10935643] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3369-74 [11248085] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3375-80 [11248086] Science. 2001 Jun 22;292(5525):2329-33 [11408620] Endocr Rev. 2002 Oct;23(5):687-702 [12372848] Biochem Biophys Res Commun. 2003 Jan 10;300(2):278-84 [12504080] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4150-5 [12644700] Mol Pharmacol. 2003 Jul;64(1):42-50 [12815159] Drug Metab Dispos. 2003 Aug;31(8):1054-64 [12867495] J Biol Chem. 2003 Nov 7;278(45):43919-27 [12920130] Expert Opin Ther Targets. 2004 Feb;8(1):49-54 [14996618] J Clin Invest. 1998 Sep 1;102(5):1016-23 [9727070] Hepatology. 2005 Jan;41(1):168-76 [15619241] Hepatology. 2005 Mar;41(3):497-505 [15726644] J Pharmacol Sci. 2005 Feb;97(2):177-83 [15725701] Endocrinology. 2005 Jul;146(7):2911-9 [15817670] Drug Metab Dispos. 2005 Jul;33(7):892-5 [15845749] Mol Pharmacol. 2005 Aug;68(2):403-13 [15872116] Curr Drug Metab. 2005 Aug;6(4):289-98 [16101569] J Pharmacol Exp Ther. 2006 Mar;316(3):1328-34 [16291874] Mol Endocrinol. 2006 Feb;20(2):279-90 [16195250] J Biol Chem. 2006 Apr 7;281(14):9127-36 [16467307] J Biol Chem. 2006 Jun 30;281(26):17882-9 [16608838] Cell Metab. 2006 Sep;4(3):177-8 [16950133] Mol Endocrinol. 2007 Jan;21(1):138-47 [16973756] Drug Metab Dispos. 2007 Feb;35(2):194-200 [17093002] Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1114-22 [17170021] J Pharmacol Exp Ther. 2007 Jul;322(1):391-8 [17442842] Mol Cell Biol. 2007 Nov;27(22):7947-54 [17875939] J Clin Invest. 2007 Nov;117(11):3583-92 [17975676] Gastroenterology. 2008 Feb;134(2):556-67 [18242221] Mol Endocrinol. 2008 Apr;22(4):838-57 [18096694] Mol Endocrinol. 2008 Apr;22(4):868-80 [18096695] Expert Opin Drug Metab Toxicol. 2008 Jul;4(7):895-908 [18624678] Mol Pharmacol. 2008 Sep;74(3):662-72 [18579710] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1476-5381.2010.01129.x ER - TY - JOUR T1 - The prostaglandin E2 receptor, EP2, regulates survivin expression via an EGFR/STAT3 pathway in UVB-exposed mouse skin. AN - 866047764; 21268125 AB - We previously reported that cycloogenase (COX)-2-generated prostaglandin E2 (PGE2) had anti-apoptotic effects in UVB-exposed mouse skin that involved EP2-mediated signaling (Chun et al., Cancer Res. 2007; 67: 2015). Because survivin is a regulator of cell survival, the possible involvement of COX-2 and EP2 in survivin expression following UVB exposure of mouse skin was investigated. In wild type mice, UVB exposure time-dependently increased the levels of survivin and phosphorylated-signal transducer and activator of transcription 3 (p-STAT3), a transcription factor that regulates survivin expression; and COX-2- or EP2-deficiency significantly reduced their induction. Topical application of the COX-2 inhibitor, celecoxib, also reduced UVB-induced survivin levels. To further investigate the roles of PGE2 and EP2 in the regulation of survivin, indomethacin was used to inhibit UVB-induced endogenous PG production. UVB-induced survivin levels were reduced by indomethacin, and PGE2 and the EP2 agonist, butaprost, partially restored survivin levels. The epidermal growth factor receptor (EGFR) is a downstream effector of EP2 and EGFR inhibition (AG1478) significantly reduced UVB activation of STAT3 and survivin levels. UVB-induced epidermal apoptosis in COX-2-/- mice was reduced by butaprost and EGFR inhibition blocked butaprost’s protective effects. Furthermore, butaprost in the absence of UVB exposure time-dependently increased p-EGFR, p-STAT3, and survivin levels in naïve mouse skin, whereas the EP4 agonist, PGE1 alcohol, did not significantly increase p-STAT3 or survivin levels. These data suggest that COX-2-generated PGE2 regulates survivin expression in mouse skin, in part, via an EP2-mediated EGFR/STAT3 pathway. Therefore, targeting the EP2/survivin pathway may provide a strategy for the chemoprevention/chemotherapy of skin cancer. Copyright © 2011 Wiley-Liss, Inc. JF - Molecular carcinogenesis AU - Chun, Kyung-Soo AU - Langenbach, Robert AD - Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 439 EP - 448 VL - 50 IS - 6 KW - Birc5 protein, mouse KW - 0 KW - Inhibitor of Apoptosis Proteins KW - RNA, Messenger KW - Receptors, Prostaglandin E, EP2 Subtype KW - Repressor Proteins KW - STAT3 Transcription Factor KW - Ptgs2 protein, mouse KW - EC 1.14.99.- KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - EGFR protein, mouse KW - EC 2.7.10.1 KW - Receptor, Epidermal Growth Factor KW - Index Medicus KW - Animals KW - Cell Proliferation -- radiation effects KW - Electrophoretic Mobility Shift Assay KW - Apoptosis -- radiation effects KW - Immunoprecipitation KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Mice, Knockout KW - Blotting, Western KW - Phosphorylation -- radiation effects KW - Mice, Inbred C57BL KW - Female KW - Cyclooxygenase 2 -- physiology KW - Ultraviolet Rays KW - Skin -- radiation effects KW - Receptor, Epidermal Growth Factor -- metabolism KW - Receptors, Prostaglandin E, EP2 Subtype -- physiology KW - Receptor, Epidermal Growth Factor -- genetics KW - Skin -- metabolism KW - Repressor Proteins -- metabolism KW - Inhibitor of Apoptosis Proteins -- genetics KW - STAT3 Transcription Factor -- genetics KW - STAT3 Transcription Factor -- metabolism KW - Repressor Proteins -- genetics KW - Inhibitor of Apoptosis Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866047764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=The+prostaglandin+E2+receptor%2C+EP2%2C+regulates+survivin+expression+via+an+EGFR%2FSTAT3+pathway+in+UVB-exposed+mouse+skin.&rft.au=Chun%2C+Kyung-Soo%3BLangenbach%2C+Robert&rft.aulast=Chun&rft.aufirst=Kyung-Soo&rft.date=2011-06-01&rft.volume=50&rft.issue=6&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=1098-2744&rft_id=info:doi/10.1002%2Fmc.20728 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-19 N1 - Date created - 2011-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/mc.20728 ER - TY - JOUR T1 - Site-specific radical formation in DNA induced by Cu(II)-H₂O₂ oxidizing system, using ESR, immuno-spin trapping, LC-MS, and MS/MS. AN - 865689653; 21382477 AB - Oxidative stress-related damage to the DNA macromolecule produces a multitude of lesions that are implicated in mutagenesis, carcinogenesis, reproductive cell death, and aging. Many of these lesions have been studied and characterized by various techniques. Of the techniques that are available, the comet assay, HPLC-EC, GC-MS, HPLC-MS, and especially HPLC-MS/MS remain the most widely used and have provided invaluable information on these lesions. However, accurate measurement of DNA damage has been a matter of debate. In particular, there have been reports of artifactual oxidation leading to erroneously high damage estimates. Further, most of these techniques measure the end product of a sequence of events and thus provide only limited information on the initial radical mechanism. We report here a qualitative measurement of DNA damage induced by a Cu(II)-H₂O₂ oxidizing system using immuno-spin trapping (IST) with electron paramagnetic resonance (EPR), MS, and MS/MS. The radical generated is trapped by DMPO immediately upon formation. The DMPO adduct formed is initially EPR active but subsequently is oxidized to the stable nitrone, which can then be detected by IST and further characterized by MS and MS/MS. Published by Elsevier Inc. JF - Free radical biology & medicine AU - Bhattacharjee, Suchandra AU - Deterding, Leesa J AU - Chatterjee, Saurabh AU - Jiang, Jinjie AU - Ehrenshaft, Marilyn AU - Lardinois, Olivier AU - Ramirez, Dario C AU - Tomer, Kenneth B AU - Mason, Ronald P AD - Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. bhattac1@niehs.nih.gov Y1 - 2011/06/01/ PY - 2011 DA - 2011 Jun 01 SP - 1536 EP - 1545 VL - 50 IS - 11 KW - DNA Adducts KW - 0 KW - Free Radicals KW - Nitrogen Oxides KW - nitrones KW - Copper KW - 789U1901C5 KW - DNA KW - 9007-49-2 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Oxidation-Reduction KW - Animals KW - Cattle KW - Spin Trapping -- methods KW - Electron Spin Resonance Spectroscopy KW - Nitrogen Oxides -- chemistry KW - Mass Spectrometry -- methods KW - Mice KW - Free Radicals -- chemistry KW - Cell Line KW - DNA Damage KW - DNA Adducts -- chemistry KW - DNA -- metabolism KW - DNA -- chemistry KW - DNA Adducts -- metabolism KW - Copper -- chemistry KW - Hydrogen Peroxide -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/865689653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Site-specific+radical+formation+in+DNA+induced+by+Cu%28II%29-H%E2%82%82O%E2%82%82+oxidizing+system%2C+using+ESR%2C+immuno-spin+trapping%2C+LC-MS%2C+and+MS%2FMS.&rft.au=Bhattacharjee%2C+Suchandra%3BDeterding%2C+Leesa+J%3BChatterjee%2C+Saurabh%3BJiang%2C+Jinjie%3BEhrenshaft%2C+Marilyn%3BLardinois%2C+Olivier%3BRamirez%2C+Dario+C%3BTomer%2C+Kenneth+B%3BMason%2C+Ronald+P&rft.aulast=Bhattacharjee&rft.aufirst=Suchandra&rft.date=2011-06-01&rft.volume=50&rft.issue=11&rft.spage=1536&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=1873-4596&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2011.02.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-22 N1 - Date created - 2011-05-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Chem Res Toxicol. 2001 Aug;14(8):1071-81 [11511181] Curr Med Chem. 2010;17(25):2685-98 [20586723] Annu Rev Biochem. 2002;71:51-70 [12045090] Free Radic Biol Med. 2002 Aug 1;33(3):364-9 [12126758] Free Radic Biol Med. 2002 Aug 15;33(4):441-9 [12160926] Free Radic Biol Med. 2003 Apr 1;34(7):830-9 [12654471] J Am Chem Soc. 2003 Aug 27;125(34):10154-5 [12926921] Mutat Res. 2003 Oct 29;531(1-2):5-23 [14637244] J Biol Chem. 2004 Mar 19;279(12):11600-7 [14699100] Free Radic Biol Med. 2004 May 15;36(10):1214-23 [15110386] Biochem Biophys Res Commun. 1976 SEP 20;72(2):732-8 [985507] Anal Biochem. 1984 May 15;139(1):243-62 [6331227] Science. 1988 Apr 29;240(4852):640-2 [2834821] Proc Natl Acad Sci U S A. 1989 Oct;86(20):7677-81 [2682618] Radiat Res. 1990 Apr;122(1):86-94 [2320728] Free Radic Biol Med. 1991;10(3-4):225-42 [1650738] J Biol Chem. 1992 Jan 5;267(1):166-72 [1730583] Arch Biochem Biophys. 1992 Aug 1;296(2):640-4 [1321591] Nature. 1993 Apr 22;362(6422):709-15 [8469282] Anal Chem. 1993 Aug 1;65(15):675A-682A [8372974] Environ Health Perspect. 1993 Dec;101 Suppl 5:35-44 [8013423] Carcinogenesis. 1994 Sep;15(9):2037-43 [7923599] IARC Sci Publ. 1994;(125):245-76 [7806316] Carcinogenesis. 1995 Feb;16(2):253-8 [7859356] Cancer Lett. 1995 Nov 6;97(2):233-9 [7497468] Carcinogenesis. 1996 Apr;17(4):787-91 [8625492] Lab Invest. 1997 Mar;76(3):365-74 [9121119] Mutat Res. 1997 Apr 29;375(2):183-93 [9202728] Rev Physiol Biochem Pharmacol. 1997;131:1-87 [9204689] J Biol Chem. 1997 Aug 8;272(32):19633-6 [9289489] Environ Health Perspect. 1997 Oct;105(10):1034-9 [9349826] Biochem J. 1997 Dec 1;328 ( Pt 2):565-71 [9371716] Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8353-8 [10411879] Nat Methods. 2006 Feb;3(2):123-7 [16432522] Free Radic Biol Med. 2006 Aug 1;41(3):422-30 [16843823] Rapid Commun Mass Spectrom. 2006;20(15):2235-42 [16810703] Free Radic Biol Med. 2007 Apr 1;42(7):985-92 [17349926] Nat Protoc. 2007;2(3):512-22 [17406615] J Am Chem Soc. 2007 Nov 7;129(44):13493-501 [17939657] Mutagenesis. 2008 May;23(3):143-51 [18283046] Biochemistry. 2008 Oct 28;47(43):11377-85 [18831539] J Phys Chem B. 2009 Jan 8;113(1):389-94 [19072618] Cancer Treat Rev. 2009 Feb;35(1):32-46 [18774652] Proc Nutr Soc. 1999 Nov;58(4):1007-14 [10817169] Chem Res Toxicol. 2000 Oct;13(10):1002-10 [11080049] Free Radic Biol Med. 2009 Feb 15;46(4):454-61 [19049863] J Biol Chem. 2009 Feb 27;284(9):5546-56 [19106092] Free Radic Biol Med. 2009 Jul 1;47(1):30-1 [19362140] J Natl Cancer Inst. 2009 Dec 16;101(24):1670-81 [19933942] Med Res Rev. 2010 Jul;30(4):708-49 [19626597] Free Radic Biol Med. 2010 Jun 1;48(11):1457-9 [20227488] Free Radic Biol Med. 2010 Jul 1;49(1):9-21 [20363317] J Am Chem Soc. 2001 Dec 19;123(50):12556-67 [11741420] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2011.02.034 ER - TY - JOUR T1 - Nuclear receptor CAR-regulated expression of the FAM84A gene during the development of mouse liver tumors. AN - 862790144; 21424122 AB - The nuclear xenobiotic receptor CAR is a phenobarbital (PB)-activated transcription factor. Using a mouse model of two-step liver tumorigenesis, in which tumor growth was initiated by diethyl nitrosamine (DEN) and promoted by chronic treatment with PB, we previously demonstrated that tumors developed only in the presence of CAR. Here, we have identified the FAM84A (family with sequence similarity 84, member A) gene as a CAR-regulated gene that is over-expressed during development of phenobarbital-promoted mouse liver tumors. FAM84A mRNA was induced in the liver of DEN/PB-treated mice prior to the development of liver tumors and this induction continued in the non-tumor as well as tumor tissues of a tumor-bearing liver. Western blotting demonstated that FAM84A protein expression increased in mouse liver after PB treatment; however, the FAM84A protein in liver and liver tumors was not phosphorylated at the serine 38 residue, which has been reported to correlate with morphological changes in cells. Immunohistochemistry analysis revealed the cytoplasmic localization of FAM84A protein and its expression during tumor development in normal tissues (especially in hepatocytes around the central vein), eosinophilic foci, adenomas and carcinomas. HepG2 cell-based reporter assays indicated that CAR activated the FAM84A promoter. Exogenous over-expression of FAM84A in HepG2 cells resulted in increased cell migration. The physiological function of FAM84A remains unknown, but our results suggest that FAM84A is up-regulated by CAR during the development of liver tumors, and may play an important role in the progression of liver cancer by increasing cell migration. JF - International journal of oncology AU - Kamino, Hiroki AU - Yamazaki, Yuichi AU - Saito, Kosuke AU - Takizawa, Daichi AU - Kakizaki, Satoru AU - Moore, Rick AU - Negishi, Masahiko AD - Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 1511 EP - 1520 VL - 38 IS - 6 KW - GABA Modulators KW - 0 KW - Neoplasm Proteins KW - Receptors, Cytoplasmic and Nuclear KW - constitutive androstane receptor KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Animals KW - Liver -- pathology KW - Sex Factors KW - Neoplasm Staging KW - Humans KW - Disease Models, Animal KW - Liver -- metabolism KW - Cell Line, Tumor KW - Mice KW - Cell Movement -- genetics KW - Mice, Knockout KW - Phenobarbital -- pharmacology KW - Hep G2 Cells KW - GABA Modulators -- pharmacology KW - Mice, Inbred C57BL KW - Mice, Inbred C3H KW - Promoter Regions, Genetic -- genetics KW - Female KW - Male KW - Protein Transport KW - Liver Neoplasms, Experimental -- genetics KW - Liver Neoplasms, Experimental -- pathology KW - Liver Neoplasms, Experimental -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Neoplasm Proteins -- genetics KW - Neoplasm Proteins -- metabolism KW - Gene Expression Regulation, Neoplastic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862790144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+oncology&rft.atitle=Nuclear+receptor+CAR-regulated+expression+of+the+FAM84A+gene+during+the+development+of+mouse+liver+tumors.&rft.au=Kamino%2C+Hiroki%3BYamazaki%2C+Yuichi%3BSaito%2C+Kosuke%3BTakizawa%2C+Daichi%3BKakizaki%2C+Satoru%3BMoore%2C+Rick%3BNegishi%2C+Masahiko&rft.aulast=Kamino&rft.aufirst=Hiroki&rft.date=2011-06-01&rft.volume=38&rft.issue=6&rft.spage=1511&rft.isbn=&rft.btitle=&rft.title=International+journal+of+oncology&rft.issn=1791-2423&rft_id=info:doi/10.3892%2Fijo.2011.980 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-09 N1 - Date created - 2011-04-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1999 Mar 5;274(10):6043-6 [10037683] Mol Cell Biol. 1998 Oct;18(10):5652-8 [9742082] Drug Metab Rev. 2006;38(1-2):75-87 [16684649] Int J Oncol. 2006 Aug;29(2):341-7 [16820875] Int J Biochem Cell Biol. 2007;39(1):44-84 [16978905] J Clin Pharmacol. 2007 May;47(5):566-78 [17442683] J Biol Chem. 2008 Apr 18;283(16):10425-32 [18303024] Curr Drug Metab. 2008 Sep;9(7):614-21 [18781913] Mol Biol Cell. 2008 Oct;19(10):4099-109 [18667531] Carcinogenesis. 1986 Jun;7(6):1025-8 [2871946] Nature. 2000 Oct 19;407(6806):920-3 [11057673] Annu Rev Pharmacol Toxicol. 2001;41:123-43 [11264453] Mol Pharmacol. 2002 Jan;61(1):1-6 [11752199] Carcinogenesis. 2002 Feb;23(2):341-9 [11872643] Lancet. 2003 Dec 6;362(9399):1907-17 [14667750] Cancer Lett. 2004 Jan 20;203(2):117-25 [14732219] Genetics. 2004 Jun;167(2):859-66 [15238534] Mol Cell Biol. 2004 Sep;24(18):7931-40 [15340055] Toxicol Appl Pharmacol. 2004 Sep 15;199(3):316-31 [15364547] Cancer Res. 2004 Oct 15;64(20):7197-200 [15492232] Carcinogenesis. 1986 Apr;7(4):627-31 [3698194] Carcinogenesis. 1992 May;13(5):739-50 [1586986] Jpn J Cancer Res. 1992 Oct;83(10):1052-6 [1452457] Carcinogenesis. 1996 Feb;17(2):191-6 [8625437] Acta Pharmacol Sin. 2005 Jun;26(6):659-65 [15916730] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3892/ijo.2011.980 ER - TY - JOUR T1 - Expression of lumbosacral HOX genes, crucial in kidney organogenesis, is systematically deregulated in clear cell kidney cancers. AN - 862268429; 21403516 AB - Homeobox-containing genes are involved in different stages of kidney organogenesis, from the early events in intermediate mesoderm to terminal differentiation of glomerular and tubular epithelia. The HOX genes show a unique genomic network organization and regulate normal development. The targeted disruption of paralogous group 11 HOX genes (HOX A11, HOX C11 and HOX D11) results in a complete loss of metanephric kidney induction. Despite a large amount of data are related to the early events in the kidney development, not much is known about HOX genes in advanced kidney organogenesis and carcinogenesis. Here, we compare the expression of the whole HOX gene network in late-stage human foetal kidney development with the same patterns detected in 25 pairs of normal clear cell renal carcinomas (RCCs) and 15 isolated RCC biopsy samples. In the majority of RCCs tested, HOX C11 is upregulated, whereas HOX D11, after an early involvement becomes active again at the 23rd week of the foetal kidney development, is always expressed in normal adult kidneys and is deregulated, together with HOX A11 and lumbosacral locus D HOX genes. Thus, through its function of regulating phenotype cell identity, the HOX network plays an important role in kidney carcinogenesis. Lumbosacral HOX genes are involved in the molecular alterations associated with clear cell kidney cancers and represent, through their deregulation, a molecular mark of tubular epithelial dedifferentiation occurring along tumour evolution, with the restoration of genetic programs associated with kidney organogenesis. The deregulation of lumbosacral HOX genes in RCCs supports (i) the consideration of the HOX gene transcriptome as the potential prognostic tool in kidney carcinogenesis and (ii) the possibility to foresee clinical trials with the purpose of targeting these genes to achieve a therapeutic effect in RCC patients. JF - Anti-cancer drugs AU - Cantile, Monica AU - Schiavo, Giulia AU - Franco, Renato AU - Cindolo, Luca AU - Procino, Alfredo AU - D'Armiento, Maria AU - Facchini, Gaetano AU - Terracciano, Luigi AU - Botti, Gerardo AU - Cillo, Clemente AD - Department of Surgical Pathology, National Cancer Institute G. Pascale, Naples, Italy. Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 392 EP - 401 VL - 22 IS - 5 KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Up-Regulation KW - Male KW - Female KW - Kidney Neoplasms -- genetics KW - Gene Expression Regulation, Neoplastic KW - Genes, Homeobox KW - Carcinoma, Renal Cell -- metabolism KW - Kidney Neoplasms -- metabolism KW - Kidney -- embryology KW - Kidney -- physiology KW - Carcinoma, Renal Cell -- genetics KW - Organogenesis -- genetics KW - Gene Expression Regulation, Developmental UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862268429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-cancer+drugs&rft.atitle=Expression+of+lumbosacral+HOX+genes%2C+crucial+in+kidney+organogenesis%2C+is+systematically+deregulated+in+clear+cell+kidney+cancers.&rft.au=Cantile%2C+Monica%3BSchiavo%2C+Giulia%3BFranco%2C+Renato%3BCindolo%2C+Luca%3BProcino%2C+Alfredo%3BD%27Armiento%2C+Maria%3BFacchini%2C+Gaetano%3BTerracciano%2C+Luigi%3BBotti%2C+Gerardo%3BCillo%2C+Clemente&rft.aulast=Cantile&rft.aufirst=Monica&rft.date=2011-06-01&rft.volume=22&rft.issue=5&rft.spage=392&rft.isbn=&rft.btitle=&rft.title=Anti-cancer+drugs&rft.issn=1473-5741&rft_id=info:doi/10.1097%2FCAD.0b013e32834505d3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-11 N1 - Date created - 2011-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/CAD.0b013e32834505d3 ER - TY - JOUR T1 - Parameters Favorable to Intraprostatic Radiation Dose Escalation in Men With Localized Prostate Cancer AN - 1687663260; 14979040 AB - Purpose: To identify , within the framework of a current Phase I trial, whether factors related to intraprostatic cancer lesions (IPLs) or individual patients predict the feasibility of high-dose intraprostatic irradiation. Methods and Materials: Endorectal coil MRI scans of the prostate from 42 men were evaluated for dominant IPLs. The IPLs, prostate, and critical normal tissues were contoured. Intensity-modulated radiotherapy plans were generated with the goal of delivering 75.6 Gy in 1.8-Gy fractions to the prostate, with IPLs receiving a simultaneous integrated boost of 3.6 Gy per fraction to a total dose of 151.2 Gy, 200% of the prescribed dose and the highest dose cohort in our trial. Rectal and bladder dose constraints were consistent with those outlined in current Radiation Therapy Oncology Group protocols. Results: Dominant IPLs were identified in 24 patients (57.1%). Simultaneous integrated boosts (SIB) to 200% of the prescribed dose were achieved in 12 of the 24 patients without violating dose constraints. Both the distance between the IPL and rectum and the hip-to-hip patient width on planning CT scans were associated with the feasibility to plan an SIB (p = 0.002 and p = 0.0137, respectively). Conclusions: On the basis of this small cohort, the distance between an intraprostatic lesion and the rectum most strongly predicted the ability to plan high-dose radiation to a dominant intraprostatic lesion. High-dose SIB planning seems possible for select intraprostatic lesions. JF - International Journal of Radiation Oncology, Biology, Physics AU - Housri, Nadine AU - Ning, Holly AU - Ondos, John AU - Choyke, Peter AU - Camphausen, Kevin AU - Citrin, Deborah AU - Arora, Barbara AU - Shankavaram, Uma AU - Kaushal, Aradhana Y1 - 2011/06/01/ PY - 2011 DA - 2011 Jun 01 SP - 614 EP - 620 PB - Elsevier Science, Box 882 New York NY 10159 USA VL - 80 IS - 2 SN - 0360-3016, 0360-3016 KW - Toxicology Abstracts KW - IMRT KW - Prostate cancer KW - Dose escalation KW - Radiotherapy KW - Treatment planning KW - Rectum KW - Radiation KW - Urinary bladder KW - Computed tomography KW - Magnetic resonance imaging KW - Oncology KW - Clinical trials KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1687663260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics&rft.atitle=Parameters+Favorable+to+Intraprostatic+Radiation+Dose+Escalation+in+Men+With+Localized+Prostate+Cancer&rft.au=Housri%2C+Nadine%3BNing%2C+Holly%3BOndos%2C+John%3BChoyke%2C+Peter%3BCamphausen%2C+Kevin%3BCitrin%2C+Deborah%3BArora%2C+Barbara%3BShankavaram%2C+Uma%3BKaushal%2C+Aradhana&rft.aulast=Housri&rft.aufirst=Nadine&rft.date=2011-06-01&rft.volume=80&rft.issue=2&rft.spage=614&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics&rft.issn=03603016&rft_id=info:doi/10.1016%2Fj.ijrobp.2010.06.050 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Last updated - 2015-07-23 N1 - SubjectsTermNotLitGenreText - Prostate cancer; Rectum; Radiation; Urinary bladder; Magnetic resonance imaging; Computed tomography; Radiotherapy; Oncology; Clinical trials DO - http://dx.doi.org/10.1016/j.ijrobp.2010.06.050 ER - TY - JOUR T1 - Dopamine D sub(3 receptor antagonist SB-277011A inhibits methamphetamine self-administration and methamphetamine-induced reinstatement of drug-seeking in rats) AN - 1562669542; 14977428 AB - We have previously reported that selective blockade of brain dopamine D sub(3 receptors by SB-277011A significantly attenuates cocaine self-administration and cocaine-induced reinstatement of drug-seeking behavior. In the present study, we investigated whether SB-277011A similarly inhibits methamphetamine self-administration and methamphetamine-induced reinstatement to drug-seeking behavior. Male Long-Evans rats were allowed to intravenously self-administer methamphetamine (0.05 mg/kg/infusion) under fixed-ratio 2 (FR2) or progressive-ratio (PR) reinforcement conditions, and some rats were tested for methamphetamine-induced reinstatement of drug-seeking behavior after extinction of self-administration. The effects of SB-277011A on each of these methamphetamine-supported behaviors were then tested. Acute intraperitoneal (i.p.) administration of SB-277011A failed to alter methamphetamine self-administration under FR2 reinforcement, but significantly lowered the break-point for methamphetamine self-administration under PR reinforcement. SB-277011A also significantly inhibited methamphetamine-triggered reinstatement of extinguished drug-seeking behavior. Overall, these data show that blockade of dopamine D) sub(3) receptors by SB-277011A attenuates the rewarding and incentive motivational effects of methamphetamine in rats, supporting the development of selective dopamine D sub(3 antagonists for the treatment of methamphetamine addiction.) JF - European Journal of Pharmacology AU - Higley, Amanda E AU - Kiefer, Stephen W AU - Li, Xia AU - Gaal, Jozsef AU - Xi, Zheng-Xiong AU - Gardner, Eliot L AD - National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, United States, ahigley@scripps.edu Y1 - 2011/06/01/ PY - 2011 DA - 2011 Jun 01 SP - 187 EP - 192 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 659 IS - 2-3 SN - 0014-2999, 0014-2999 KW - Toxicology Abstracts KW - Methamphetamine KW - Dopamine D sub(3 receptor) KW - SB-277011A KW - Self-administration KW - Reward KW - Reinstatement KW - Data processing KW - Extinction KW - Dopamine D3 receptors KW - Reinforcement KW - Brain KW - Addiction KW - Drug addiction KW - Drug self-administration KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1562669542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Pharmacology&rft.atitle=Dopamine+D+sub%283+receptor+antagonist+SB-277011A+inhibits+methamphetamine+self-administration+and+methamphetamine-induced+reinstatement+of+drug-seeking+in+rats%29&rft.au=Higley%2C+Amanda+E%3BKiefer%2C+Stephen+W%3BLi%2C+Xia%3BGaal%2C+Jozsef%3BXi%2C+Zheng-Xiong%3BGardner%2C+Eliot+L&rft.aulast=Higley&rft.aufirst=Amanda&rft.date=2011-06-01&rft.volume=659&rft.issue=2-3&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Pharmacology&rft.issn=00142999&rft_id=info:doi/10.1016%2Fj.ejphar.2011.02.046 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2014-10-02 N1 - SubjectsTermNotLitGenreText - Methamphetamine; Data processing; Extinction; Dopamine D3 receptors; Brain; Reinforcement; Addiction; Drug addiction; Reinstatement; Drug self-administration DO - http://dx.doi.org/10.1016/j.ejphar.2011.02.046 ER - TY - JOUR T1 - Antitumor efficacy and apoptotic activity of substituted chloroalkyl 1H-benz[de]isoquinoline-1,3-diones: a new class of potential antineoplastic agents AN - 1468360472; 18525091 AB - A series of ten chloroalkyl 1H-benz[de]isoquinoline-1,3-diones (naphthalimides) were synthesized and evaluated for antitumor activity. Amongst them, new compounds 2d and 2i carrying a 6-NO sub(2) substituent in the aromatic portion of the molecule possessed significant antineoplastic activity. The most active compound 2i had elicited significant cytotoxicity in 15 human tumor cell lines namely Leukemia: MOLT-4, HL-60; Lymphoma: U-937; Colon: 502713, HT-29, SW-620, HCT-15, COLO-205; Liver: Hep-2; Prostate DU-145, PC-3; Breast: MCF-7; Neuroblastoma: IMR-32, SK-N-SH and Ovary: OVCAR-5 out of the 17 cell lines screened. Flow cytometric analysis performed to study the effect of compound 2i on the progression of cell cycle of MOLT-4 cells, revealed rise in sub-G sub(1) fraction and concomitant accumulation of cells in S and G sub(2)/M phases, indicating apoptosis, mitotic arrest and/or delay in exit of daughter cells from mitotic cycle respectively. It also induced caspase-mediated apoptosis of MOLT-4 cells in a dose dependant manner. Light and electron microscopic studies revealed characteristic morphology of apoptotic MOLT-4 cells after in vitro treatment with 10 mu M concentration of the compound. Apoptosis induction was also observed in HL-60 cells by compounds 2d and 2i to an extent much greater than camptothecin and cis-platin at 10 mu M concentration. Both the compounds have shown minimal suppressive effect on human PBMC having high IC sub(50) values of 3,582 and 1,536 mu M respectively. These compounds inhibited DNA and RNA synthesis in murine ascites Sarcoma-180 tumor cells in vitro at 8 mu M concentration. Above results indicate promising chemotherapeutic potential of the key compound 2i. JF - Investigational New Drugs AU - Mukherjee, Asama AU - Hazra, Suva AU - Dutta, Sushanta AU - Muthiah, Shanmugavel AU - Mondhe, Dilip Manikrao AU - Sharma, Parduman Raj AU - Singh, Shashank Kumar AU - Saxena, Ajit Kumar AU - Qazi, Gulam Nabi AU - Sanyal, Utpal AD - Department of Anticancer Drug Development, Chittaranjan National Cancer Institute, Kolkata, 700026, India, utpalsanyal@yahoo.co.in Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 434 EP - 442 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 29 IS - 3 SN - 0167-6997, 0167-6997 KW - Biotechnology and Bioengineering Abstracts KW - DNA biosynthesis KW - Apoptosis KW - Cell cycle KW - Transcription KW - Camptothecin KW - Flow cytometry KW - Leukemia KW - Cytotoxicity KW - Tumor cell lines KW - Peripheral blood mononuclear cells KW - Colon KW - Ascites KW - Liver KW - DNA KW - Ovaries KW - Lymphoma KW - Prostate KW - Aromatics KW - Antitumor activity KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1468360472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigational+New+Drugs&rft.atitle=Antitumor+efficacy+and+apoptotic+activity+of+substituted+chloroalkyl+1H-benz%5Bde%5Disoquinoline-1%2C3-diones%3A+a+new+class+of+potential+antineoplastic+agents&rft.au=Mukherjee%2C+Asama%3BHazra%2C+Suva%3BDutta%2C+Sushanta%3BMuthiah%2C+Shanmugavel%3BMondhe%2C+Dilip+Manikrao%3BSharma%2C+Parduman+Raj%3BSingh%2C+Shashank+Kumar%3BSaxena%2C+Ajit+Kumar%3BQazi%2C+Gulam+Nabi%3BSanyal%2C+Utpal&rft.aulast=Mukherjee&rft.aufirst=Asama&rft.date=2011-06-01&rft.volume=29&rft.issue=3&rft.spage=434&rft.isbn=&rft.btitle=&rft.title=Investigational+New+Drugs&rft.issn=01676997&rft_id=info:doi/10.1007%2Fs10637-009-9372-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-12-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - DNA biosynthesis; Apoptosis; Cell cycle; Transcription; Camptothecin; Flow cytometry; Leukemia; Peripheral blood mononuclear cells; Tumor cell lines; Cytotoxicity; Colon; Ascites; DNA; Liver; Ovaries; Prostate; Lymphoma; Aromatics; Antitumor activity DO - http://dx.doi.org/10.1007/s10637-009-9372-z ER - TY - JOUR T1 - Impact of Genetic Causal Information on Medical Students' Clinical Encounters with an Obese Virtual Patient: Health Promotion and Social Stigma AN - 1427004688; 16419063 AB - Background: Health care providers will increasingly encounter information about the genetics of obesity as genetics research progresses. Purpose: This study explores whether information about the genetics of obesity reduces medical student stigmatization of obese patients, and how it affects rates of health behavior-related referral. Methods: One hundred and ten third and fourth year medical students were randomly assigned to read about genetic or behavioral mechanisms of obesity, or a control topic. Students interacted with an obese virtual patient in a virtual clinic and completed a battery of measures. Results: Rates of most health behavior screening recommendations (weight loss, exercise, and diet consultations) were lower among participants exposed to genetic causal information than control. The genetic causal information group exhibited less negative stereotyping of the patient than control, F(1,105)=5.00, p=0.028, but did not differ in anticipated patient adherence, F(1,105)=3.18, p=0.077. Conclusions: Information highlighting genetic contributions to obesity may lead to both positive and negative outcomes. Communication about the genetics of obesity should discuss the multi-factorial and non-deterministic nature of genetic risk. JF - Annals of Behavioral Medicine AU - Persky, Susan AU - Eccleston, Collette P AD - Social and Behavioral Research Branch, National Human Genome Research Institute, NIH, 31 Center Drive, Room B1B36, Bethesda, MD, 20892, USA, perskys@mail.nih.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 363 EP - 372 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 41 IS - 3 SN - 0883-6612, 0883-6612 KW - Physical Education Index KW - Genetics KW - Obesity KW - Health (care) KW - Weight control KW - Consultation KW - Health (behavior) KW - Patients KW - Students KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1427004688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Behavioral+Medicine&rft.atitle=Impact+of+Genetic+Causal+Information+on+Medical+Students%27+Clinical+Encounters+with+an+Obese+Virtual+Patient%3A+Health+Promotion+and+Social+Stigma&rft.au=Persky%2C+Susan%3BEccleston%2C+Collette+P&rft.aulast=Persky&rft.aufirst=Susan&rft.date=2011-06-01&rft.volume=41&rft.issue=3&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Annals+of+Behavioral+Medicine&rft.issn=08836612&rft_id=info:doi/10.1007%2Fs12160-010-9242-0 LA - English DB - Physical Education Index N1 - Date revised - 2013-08-01 N1 - Last updated - 2013-08-23 N1 - SubjectsTermNotLitGenreText - Obesity; Genetics; Health (care); Weight control; Consultation; Health (behavior); Patients; Students DO - http://dx.doi.org/10.1007/s12160-010-9242-0 ER - TY - JOUR T1 - Cigarette smoking and short-term addiction treatment outcome AN - 1323798288; 14976896 AB - Cigarette smoking is common among patients in cocaine and opioid dependence treatment, and may influence treatment outcome. We addressed this issue in a secondary analysis of data from an outpatient clinical trial of buprenorphine treatment for concurrent cocaine and opioid dependence (13 weeks, N = 200). The association between cigarette smoking (lifetime cigarette smoking status, number of cigarettes smoked per day prior to study entry) and short-term treatment outcome (% of urine samples positive for cocaine or opioids, treatment retention) was evaluated with analysis of covariance, bivariate correlations, and multivariate linear regression. Nicotine-dependent smokers (66% of participants) had a significantly higher percentage of cocaine-positive urine samples than non-smokers (12% of participants) (76% vs. 62%), but did not differ in percentage of opioid-positive urine samples or treatment retention. Number of cigarettes smoked per day at baseline was positively associated with percentage of cocaine-positive urine samples, even after controlling for baseline sociodemographic and drug use characteristics, but was not significantly associated with percentage of opioid-positive urine samples or treatment retention. These results suggest that cigarette smoking is associated with poorer short-term outcome of outpatient treatment for cocaine dependence, but perhaps not of concurrent opioid dependence, and support the importance of offering smoking cessation treatment to cocaine-dependent patients. JF - Drug and Alcohol Dependence AU - Harrell, P T AU - Montoya, I D AU - Preston, K L AU - Juliano, L M AU - Gorelick, DA AD - Intramural Research Program, NIDA, NIH, Baltimore, MD 21224, USA, dgorelic@intra.nida.nih.gov Y1 - 2011/06/01/ PY - 2011 DA - 2011 Jun 01 SP - 161 EP - 166 PB - Elsevier Science, P.O. Box 85 Limerick Ireland VL - 115 IS - 3 SN - 0376-8716, 0376-8716 KW - Toxicology Abstracts KW - Addiction KW - Buprenorphine KW - Cigarette smoking KW - Clinical trials KW - Cocaine KW - Data processing KW - Drug abuse KW - Drug addiction KW - Drug dependence KW - Opioids KW - Smoking KW - Urine KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1323798288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Cigarette+smoking+and+short-term+addiction+treatment+outcome&rft.au=Harrell%2C+P+T%3BMontoya%2C+I+D%3BPreston%2C+K+L%3BJuliano%2C+L+M%3BGorelick%2C+DA&rft.aulast=Harrell&rft.aufirst=P&rft.date=2011-06-01&rft.volume=115&rft.issue=3&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2010.08.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-04-01 N1 - Last updated - 2013-04-05 N1 - SubjectsTermNotLitGenreText - Smoking; Drug dependence; Buprenorphine; Data processing; Urine; Cigarette smoking; Opioids; Addiction; Drug addiction; Drug abuse; Cocaine; Clinical trials DO - http://dx.doi.org/10.1016/j.drugalcdep.2010.08.017 ER - TY - JOUR T1 - Breast cancer risk among patients with Klinefelter syndrome AN - 1093414431; 14704220 AB - Aim: To evaluate male breast cancer (MBC) risk among patients with Klinefelter syndrome (KS) and relate this to possible biological explanations. Methods: A literature review was conducted to identify case series and epidemiologic studies that have evaluated MBC risk among patients with KS. Results: Case reports without expected values have often led to false impressions of risk. Problems include that a diagnosis of cancer can prompt a karyotypic evaluation and that many cases of KS are unrecognized, resulting in incomplete denominators. Few carefully conducted epidemiologic studies have been undertaken given that both KS and MBC are rare events. The largest study found 19.2- and 57.8-fold increases in incidence and mortality, respectively, with particularly high risks among 47,XXY mosaics. These risks were still approximately 70% lower than among females, contradicting case reports that patients with KS have breast cancer rates similar to females. Altered hormone levels (especially the ratio of oestrogens to androgens), administration of exogenous androgens, gynaecomastia and genetic factors have been offered as possible explanations for the high risks. Conclusions: Additional well-designed epidemiologic studies are needed to clarify which patients with KS are at a high risk of developing MBC and to distinguish between possible predisposing factors, including altered endogenous hormones. JF - Acta Paediatrica AU - Brinton, Louise A AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Boulevard, Rockville, MD, USA Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 814 EP - 818 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 100 IS - 6 SN - 0803-5253, 0803-5253 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Breast cancer KW - Genetic factors KW - Health risks KW - Hormones KW - Literature reviews KW - Mortality KW - Mosaics KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1093414431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Paediatrica&rft.atitle=Breast+cancer+risk+among+patients+with+Klinefelter+syndrome&rft.au=Brinton%2C+Louise+A&rft.aulast=Brinton&rft.aufirst=Louise&rft.date=2011-06-01&rft.volume=100&rft.issue=6&rft.spage=814&rft.isbn=&rft.btitle=&rft.title=Acta+Paediatrica&rft.issn=08035253&rft_id=info:doi/10.1111%2Fj.1651-2227.2010.02131.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Document feature - figure 0 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Mortality; Health risks; Genetic factors; Literature reviews; Mosaics; Breast cancer; Hormones DO - http://dx.doi.org/10.1111/j.1651-2227.2010.02131.x ER - TY - JOUR T1 - Hyperventilation as a Simple Cure for Severe Exercise-Associated Muscle Cramping AN - 1020851643; 15214266 JF - Pain Medicine AU - Murphy, Philip M AU - Murphy, Carolyn A AD - Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 987 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 12 IS - 6 SN - 1526-2375, 1526-2375 KW - Physical Education Index KW - Hyperventilation KW - Muscles KW - Pain KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020851643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pain+Medicine&rft.atitle=Hyperventilation+as+a+Simple+Cure+for+Severe+Exercise-Associated+Muscle+Cramping&rft.au=Murphy%2C+Philip+M%3BMurphy%2C+Carolyn+A&rft.aulast=Murphy&rft.aufirst=Philip&rft.date=2011-06-01&rft.volume=12&rft.issue=6&rft.spage=987&rft.isbn=&rft.btitle=&rft.title=Pain+Medicine&rft.issn=15262375&rft_id=info:doi/10.1111%2Fj.1526-4637.2011.01112.x LA - English DB - Physical Education Index N1 - Date revised - 2012-06-01 N1 - Number of references - 1 N1 - Document feature - figure 0 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Muscles; Hyperventilation; Pain DO - http://dx.doi.org/10.1111/j.1526-4637.2011.01112.x ER - TY - JOUR T1 - A population-based assessment of mortality and morbidity patterns among patients with thymoma AN - 1017960693; 16689986 AB - Thymomas are rare tumors of the mediastinum; a limited number of small studies have evaluated the outcomes in these patients. We identified 668 patients with thymoma from the Swedish Cancer Registry, and 2,719 population-based matched controls. We obtained information on autoimmunity from the nationwide inpatient/outpatient hospital discharge Registry. We constructed Kaplan-Meier curves for survival analysis, conditional regression and Cox proportional hazards models to evaluate the association between thymoma and autoimmune diseases, and standardized incidence ratios (SIRs) to evaluate the risk for second cancers following thymoma. Compared with controls, patients with benign or malignant thymoma had a poorer (p < 0.001) 5-year (79%, 53% vs. 91%), 10-year (65%, 39% vs. 78%) and 20-year (43%, 18% vs. 55%) overall survival. For thymoma patients, younger age at diagnosis and being diagnosed in recent years were associated with a better survival. Compared with controls, thymoma patients were more likely to have an autoimmune disease at some point during their lives (32.7% vs. 2.4%, respectively, p < 0.001), most frequently myasthenia gravis (24.5%), systemic lupus erythematosus (2.4%) and red cell aplasia (1.2%). Thymoma patients had twofold excess risk for second cancers compared with the general population, most notably: non-melanoma skin cancer (SIR = 10.6, 95% confidence intervals (CI) = 6.0-17.3), non-Hodgkin lymphoma (SIR = 6.8, 95% CI = 3.00-13.0), and cervical (SIR = 6.9, 95% CI = 1.4-20.1), endocrine (SIR = 4.7, 95% CI = 1.3-12.0), and prostate cancer (SIR = 3.0, 95% CI = 1.7-4.8). Despite the improved survival for thymoma patients over time, they have worse survival than controls. Thymoma patients are in need for follow-up to detect and manage autoimmune diseases and cancer. JF - International Journal of Cancer AU - Gadalla, Shahinaz M AU - Rajan, Arun AU - Pfeiffer, Ruth AU - Kristinsson, Sigurdur Y AU - Bjorkholm, Magnus AU - Landgren, Ola AU - Giaccone, Giuseppe AD - Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, giacconeg@mail.nih.gov Y1 - 2011/06/01/ PY - 2011 DA - 2011 Jun 01 SP - 2688 EP - 2694 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 128 IS - 11 SN - 1097-0215, 1097-0215 KW - Risk Abstracts KW - Mortality KW - Skin KW - autoimmune diseases KW - Standards KW - tumors KW - survival KW - Cancer KW - Morbidity KW - Hospitals KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017960693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=A+population-based+assessment+of+mortality+and+morbidity+patterns+among+patients+with+thymoma&rft.au=Gadalla%2C+Shahinaz+M%3BRajan%2C+Arun%3BPfeiffer%2C+Ruth%3BKristinsson%2C+Sigurdur+Y%3BBjorkholm%2C+Magnus%3BLandgren%2C+Ola%3BGiaccone%2C+Giuseppe&rft.aulast=Gadalla&rft.aufirst=Shahinaz&rft.date=2011-06-01&rft.volume=128&rft.issue=11&rft.spage=2688&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=10970215&rft_id=info:doi/10.1002%2Fijc.25583 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ijc.25583/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2014-05-29 N1 - SubjectsTermNotLitGenreText - Mortality; Skin; autoimmune diseases; tumors; Standards; survival; Morbidity; Cancer; Hospitals DO - http://dx.doi.org/10.1002/ijc.25583 ER - TY - JOUR T1 - Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1). AN - 868625304; 21528848 AB - PPM1D (PP2Cδ or Wip1) was identified as a wild-type p53-induced Ser/Thr phosphatase that accumulates after DNA damage and classified into the PP2C family. It dephosphorylates and inactivates several proteins critical for cellular stress responses, including p38 MAPK, p53, and ATM. Furthermore, PPM1D is amplified and/or overexpressed in a number of human cancers. Thus, inhibition of its activity could constitute an important new strategy for therapeutic intervention to halt the progression of several different cancers. Previously, we reported the development of a cyclic thioether peptide with low micromolar inhibitory activity toward PPM1D. Here, we describe important improvements in the inhibitory activity of this class of cyclic peptides and also present a binding model based upon the results. We found that specific interaction of an aromatic ring at the X1 position and negative charge at the X5 and X6 positions significantly increased the inhibitory activity of the cyclic peptide, with the optimized molecule having a K(i) of 110 nM. To the best of our knowledge, this represents the highest inhibitory activity reported for an inhibitor of PPM1D. We further developed an inhibitor selective for PPM1D over PPM1A with a K(i) of 2.9 μM. Optimization of the cyclic peptide and mutagenesis experiments suggest that a highly basic loop unique to PPM1D is related to substrate specificity. We propose a new model for the catalytic site of PPM1D and inhibition by the cyclic peptides that will be useful both for the subsequent design of PPM1D inhibitors and for identification of new substrates. JF - Biochemistry AU - Hayashi, Ryo AU - Tanoue, Kan AU - Durell, Stewart R AU - Chatterjee, Deb K AU - Jenkins, Lisa M Miller AU - Appella, Daniel H AU - Appella, Ettore AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2011/05/31/ PY - 2011 DA - 2011 May 31 SP - 4537 EP - 4549 VL - 50 IS - 21 KW - DNA Primers KW - 0 KW - Enzyme Inhibitors KW - Peptides, Cyclic KW - PPM1A protein, human KW - EC 3.1.3.16 KW - PPM1D protein, human KW - Phosphoprotein Phosphatases KW - Protein Phosphatase 2C KW - Index Medicus KW - Base Sequence KW - Models, Molecular KW - Humans KW - Molecular Sequence Data KW - Circular Dichroism KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Phosphoprotein Phosphatases -- antagonists & inhibitors KW - Enzyme Inhibitors -- pharmacology KW - Phosphoprotein Phosphatases -- genetics KW - Phosphoprotein Phosphatases -- chemistry KW - Peptides, Cyclic -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/868625304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Optimization+of+a+cyclic+peptide+inhibitor+of+Ser%2FThr+phosphatase+PPM1D+%28Wip1%29.&rft.au=Hayashi%2C+Ryo%3BTanoue%2C+Kan%3BDurell%2C+Stewart+R%3BChatterjee%2C+Deb+K%3BJenkins%2C+Lisa+M+Miller%3BAppella%2C+Daniel+H%3BAppella%2C+Ettore&rft.aulast=Hayashi&rft.aufirst=Ryo&rft.date=2011-05-31&rft.volume=50&rft.issue=21&rft.spage=4537&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=1520-4995&rft_id=info:doi/10.1021%2Fbi101949t LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-25 N1 - Date created - 2011-05-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Metastasis Rev. 2008 Jun;27(2):123-35 [18265945] ChemMedChem. 2008 Feb;3(2):230-2 [18022979] Protein Pept Lett. 2008;15(9):938-48 [18991770] J Comput Chem. 2009 Jul 30;30(10):1545-614 [19444816] Cell. 2009 Oct 30;139(3):468-84 [19879837] J Cell Biol. 2010 Mar 22;188(6):759-68 [20231381] Pharm Res. 2011 Feb;28(2):187-99 [20549313] Expert Opin Drug Deliv. 2011 Mar;8(3):281-98 [21306284] ChemMedChem. 2011 Apr 4;6(4):678-85 [21370475] Nat Rev Mol Cell Biol. 2007 Mar;8(3):234-44 [17318227] Nucleic Acids Res. 2000 Jan 1;28(1):235-42 [10592235] EMBO J. 2000 Dec 1;19(23):6517-26 [11101524] J Cell Sci. 2002 Jan 15;115(Pt 2):241-56 [11839776] Nat Genet. 2002 Jun;31(2):133-4 [12021784] Cancer Res. 2003 Apr 15;63(8):1876-83 [12702577] Breast Cancer Res Treat. 2003 Apr;78(3):313-22 [12755490] Clin Cancer Res. 2003 Jun;9(6):1995-2004 [12796361] Clin Exp Metastasis. 2003;20(4):357-64 [12856723] FASEB J. 2004 Jan;18(1):8-30 [14718383] Nat Genet. 2004 Apr;36(4):343-50 [14991053] Cell. 2004 Jun 11;117(6):699-711 [15186772] J Comput Chem. 2004 Oct;25(13):1605-12 [15264254] Trends Mol Med. 2004 Aug;10(8):359-61 [15310454] Acta Biochim Pol. 1985;32(3):187-97 [2418612] Curr Opin Struct Biol. 1996 Jun;6(3):377-85 [8804824] EMBO J. 1996 Dec 16;15(24):6798-809 [9003755] Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6048-53 [9177166] Biochemistry. 1997 Aug 19;36(33):10006-14 [9254595] Structure. 2004 Nov;12(11):1947-54 [15530359] Curr Opin Cell Biol. 2005 Apr;17(2):197-202 [15780597] Biochemistry. 2005 Apr 12;44(14):5285-94 [15807522] Genes Dev. 2005 May 15;19(10):1162-74 [15870257] Cancer Biol Ther. 2005 Oct;4(10):1154-8 [16258255] Curr Med Chem. 2005;12(26):3127-41 [16375706] J Pathol. 2006 Mar;208(4):554-63 [16400626] Cell Death Differ. 2006 Jul;13(7):1170-80 [16311512] J Biol Chem. 2006 Aug 25;281(34):24847-62 [16798742] Mol Cell. 2006 Sep 1;23(5):757-64 [16949371] Biochemistry. 2006 Nov 7;45(44):13193-202 [17073441] Cancer Sci. 2007 Mar;98(3):392-400 [17233815] Oncogene. 2007 Mar 1;26(10):1449-58 [16936775] FEBS J. 2007 Jun;274(12):3128-37 [17521332] Structure. 2007 Jul;15(7):863-72 [17637345] Pharm Res. 2007 Nov;24(11):1977-92 [17443399] Biochemistry. 2007 Nov 6;46(44):12594-603 [17939684] J Mol Biol. 2007 Dec 7;374(4):890-8 [17961594] J Struct Funct Genomics. 2007 Sep;8(2-3):121-40 [18058037] J Mol Biol. 2008 Feb 15;376(2):570-81 [18164312] Oncogene. 2008 Feb 14;27(8):1036-44 [17700519] Adv Drug Deliv Rev. 2008 Mar 1;60(4-5):572-9 [18045726] Org Biomol Chem. 2008 Jul 7;6(13):2242-55 [18563254] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/bi101949t ER - TY - JOUR T1 - Malaria Parasite clag3 Genes Determine Channel-Mediated Nutrient Uptake by Infected Red Blood Cells AN - 876243663; 14961996 AB - Development of malaria parasites within vertebrate erythrocytes requires nutrient uptake at the host cell membrane. The plasmodial surface anion channel (PSAC) mediates this transport and is an antimalarial target, but its molecular basis is unknown. We report a parasite gene family responsible for PSAC activity. We used high-throughput screening for nutrient uptake inhibitors to identify a compound highly specific for channels from the Dd2 line of the human pathogen P. falciparum. Inheritance of this compound's affinity in a Dd2 x HB3 genetic cross maps to a single parasite locus on chromosome 3. DNA transfection and in vitro selections indicate that PSAC-inhibitor interactions are encoded by two clag3 genes previously assumed to function in cytoadherence. These genes are conserved in plasmodia, exhibit expression switching, and encode an integral protein on the host membrane, as predicted by functional studies. This protein increases host cell permeability to diverse solutes. PaperFlick: AB: JF - Cell AU - Nguitragool, Wang AU - Bokhari, Abdullah AB AU - Pillai, Ajay D AU - Rayavara, Kempaiah AU - Sharma, Paresh AU - Turpin, Brad AU - Aravind, L AU - Desai, Sanjay A Y1 - 2011/05/27/ PY - 2011 DA - 2011 May 27 SP - 665 EP - 677 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA VL - 145 IS - 5 SN - 0092-8674, 0092-8674 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Human diseases KW - Heredity KW - Erythrocytes KW - Cell permeability KW - Malaria KW - chromosome 3 KW - Hosts KW - Solutes KW - Cell membranes KW - Antimalarial agents KW - Anion channels KW - high-throughput screening KW - Plasmodia KW - Nutrient uptake KW - Plasmodium falciparum KW - Pathogens KW - Antibodies KW - Transfection KW - DNA KW - Uptake KW - Gene mapping KW - Q1 08484:Species interactions: parasites and diseases KW - G 07730:Development & Cell Cycle KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876243663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Malaria+Parasite+clag3+Genes+Determine+Channel-Mediated+Nutrient+Uptake+by+Infected+Red+Blood+Cells&rft.au=Nguitragool%2C+Wang%3BBokhari%2C+Abdullah+AB%3BPillai%2C+Ajay+D%3BRayavara%2C+Kempaiah%3BSharma%2C+Paresh%3BTurpin%2C+Brad%3BAravind%2C+L%3BDesai%2C+Sanjay+A&rft.aulast=Nguitragool&rft.aufirst=Wang&rft.date=2011-05-27&rft.volume=145&rft.issue=5&rft.spage=665&rft.isbn=&rft.btitle=&rft.title=Cell&rft.issn=00928674&rft_id=info:doi/10.1016%2Fj.cell.2011.05.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Solutes; Parasites; Human diseases; Cell membranes; Erythrocytes; Uptake; Malaria; Pathogens; Hosts; Heredity; Cell permeability; chromosome 3; Antibodies; Transfection; DNA; Anion channels; Antimalarial agents; high-throughput screening; Nutrient uptake; Plasmodia; Gene mapping; Plasmodium falciparum DO - http://dx.doi.org/10.1016/j.cell.2011.05.002 ER - TY - JOUR T1 - Occupational exposure to dusts and risk of renal cell carcinoma AN - 876236085; 14908579 AB - Background: Occupational exposures to dusts have generally been examined in relation to cancers of the respiratory system and have rarely been examined in relation to other cancers, such as renal cell carcinoma (RCC). Although previous epidemiological studies, though few, have shown certain dusts, such as asbestos, to increase renal cancer risk, the potential for other occupational dust exposures to cause kidney damage and/or cancer may exist. We investigated whether asbestos, as well as 20 other occupational dust exposures, were associated with RCC risk in a large European, multi-center, hospital-based renal case-control study. Methods: General occupational histories and job-specific questionnaires were reviewed by occupational hygienists for subject-specific information. Odds ratios (ORs) and 95% confidence intervals (95% CIs) between RCC risk and exposures were calculated using unconditional logistic regression. Results: Among participants ever exposed to dusts, significant associations were observed for glass fibres (OR: 2.1; 95% CI: 1.1-3.9), mineral wool fibres (OR: 2.5; 95% CI: 1.2-5.1), and brick dust (OR: 1.5; 95% CI: 1.0-2.4). Significant trends were also observed with exposure duration and cumulative exposure. No association between RCC risk and asbestos exposure was observed. Conclusion: Results suggest that increased RCC risk may be associated with occupational exposure to specific types of dusts. Additional studies are needed to replicate and extend findings. JF - British Journal of Cancer AU - Karami, S AU - Boffetta, P AU - Stewart, P S AU - Brennan, P AU - Zaridze, D AU - Matveev, V AU - Janout, V AU - Kollarova, H AU - Bencko, V AU - Navratilova, M AU - Szeszenia-Dabrowska, N AU - Mates, D AU - Gromiec, J AU - Slamova, A AU - Chow, W-H AU - Rothman, N AU - Moore, L E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Occupational and Environmental Epidemiology Branch, 6120 Executive Boulevard, EPS 8121, Rockville, MD 20852, USA Y1 - 2011/05/24/ PY - 2011 DA - 2011 May 24 SP - 1797 EP - 1803 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 104 IS - 11 SN - 0007-0920, 0007-0920 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Inventories KW - Asbestos KW - Cancer KW - Dust KW - Wool KW - renal cell carcinoma KW - Reviews KW - Kidney KW - Minerals KW - Occupational exposure KW - Respiratory system KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876236085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Occupational+exposure+to+dusts+and+risk+of+renal+cell+carcinoma&rft.au=Karami%2C+S%3BBoffetta%2C+P%3BStewart%2C+P+S%3BBrennan%2C+P%3BZaridze%2C+D%3BMatveev%2C+V%3BJanout%2C+V%3BKollarova%2C+H%3BBencko%2C+V%3BNavratilova%2C+M%3BSzeszenia-Dabrowska%2C+N%3BMates%2C+D%3BGromiec%2C+J%3BSlamova%2C+A%3BChow%2C+W-H%3BRothman%2C+N%3BMoore%2C+L+E&rft.aulast=Karami&rft.aufirst=S&rft.date=2011-05-24&rft.volume=104&rft.issue=11&rft.spage=1797&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fbjc.2011.148 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Wool; Inventories; Asbestos; renal cell carcinoma; Reviews; Kidney; Minerals; Occupational exposure; Dust; Respiratory system; Historical account; Cancer DO - http://dx.doi.org/10.1038/bjc.2011.148 ER - TY - CPAPER T1 - Development of Genetic Systems for Coxiella burnetii T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1313055597; 6038321 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Beare, Paul Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Public health KW - Epidemiology KW - Microbiology KW - Coxiella burnetii UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313055597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Development+of+Genetic+Systems+for+Coxiella+burnetii&rft.au=Beare%2C+Paul&rft.aulast=Beare&rft.aufirst=Paul&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Interactions of Chlamydial Secreted Effectors with the Host Cytoskeleton T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312985893; 6039296 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Hackstadt, Ted Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Cytoskeleton UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312985893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Interactions+of+Chlamydial+Secreted+Effectors+with+the+Host+Cytoskeleton&rft.au=Hackstadt%2C+Ted&rft.aulast=Hackstadt&rft.aufirst=Ted&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Aspergillus fumigatus "Supermaters" T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312976592; 6036404 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Sugui, J AU - Chang, Y AU - Kwon-Chung, K AU - Wickes, B AU - Dyer, P Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Insecticides KW - Aspergillus fumigatus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312976592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Aspergillus+fumigatus+%22Supermaters%22&rft.au=Sugui%2C+J%3BChang%2C+Y%3BKwon-Chung%2C+K%3BWickes%2C+B%3BDyer%2C+P&rft.aulast=Sugui&rft.aufirst=J&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The Linear Plasmid lp38 is Dispensable for Completion of the Borrelia burgdorferi Mouse-Tick Infectious Cycle T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312957269; 6038618 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Dulebohn, D AU - Bestor, A AU - Rego, R AU - Rosa, P Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Plasmids KW - Borrelia burgdorferi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312957269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=The+Linear+Plasmid+lp38+is+Dispensable+for+Completion+of+the+Borrelia+burgdorferi+Mouse-Tick+Infectious+Cycle&rft.au=Dulebohn%2C+D%3BBestor%2C+A%3BRego%2C+R%3BRosa%2C+P&rft.aulast=Dulebohn&rft.aufirst=D&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A Multi-Center Epidemiologic Survey of Rotaviruses and Noroviruses in Asia, Africa, and South America as Determined from Archival WHO Specimens T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312944381; 6039016 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Rackoff, L AU - Bok, K AU - Green, K AU - Kapikian, A Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Africa KW - South America KW - Asia KW - Public health KW - Epidemiology KW - Microbiology KW - Norovirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312944381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=A+Multi-Center+Epidemiologic+Survey+of+Rotaviruses+and+Noroviruses+in+Asia%2C+Africa%2C+and+South+America+as+Determined+from+Archival+WHO+Specimens&rft.au=Rackoff%2C+L%3BBok%2C+K%3BGreen%2C+K%3BKapikian%2C+A&rft.aulast=Rackoff&rft.aufirst=L&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The Beta-flap Tip of Escherichia coli Core RNA Polymerase and the Bacteriophage T4 Activator MotA Target an Overlapping Set of C-terminal Sigma70 Residues T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312939103; 6037534 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Bonocora, R AU - Hsieh, M AU - Jha, S AU - Knipling, L AU - Hinton, D Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Residues KW - Phages KW - DNA-directed RNA polymerase KW - Bacteriophages KW - Escherichia coli UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312939103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=The+Beta-flap+Tip+of+Escherichia+coli+Core+RNA+Polymerase+and+the+Bacteriophage+T4+Activator+MotA+Target+an+Overlapping+Set+of+C-terminal+Sigma70+Residues&rft.au=Bonocora%2C+R%3BHsieh%2C+M%3BJha%2C+S%3BKnipling%2C+L%3BHinton%2C+D&rft.aulast=Bonocora&rft.aufirst=R&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Beyond the Central Dogma: Regulation by Proteolysis and Small RNAs T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312930408; 6037263 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Gottesman, Susan Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Proteolysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312930408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Beyond+the+Central+Dogma%3A+Regulation+by+Proteolysis+and+Small+RNAs&rft.au=Gottesman%2C+Susan&rft.aulast=Gottesman&rft.aufirst=Susan&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Regulatory Responses During Parasitic Infection T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312930231; 6037259 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Belkaid, Yasmine Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - infection KW - Infection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312930231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Regulatory+Responses+During+Parasitic+Infection&rft.au=Belkaid%2C+Yasmine&rft.aulast=Belkaid&rft.aufirst=Yasmine&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Non-bench Science Careers at the National Institutes of Health T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312927491; 6037800 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Mills, Melody Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - careers KW - Careers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312927491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Non-bench+Science+Careers+at+the+National+Institutes+of+Health&rft.au=Mills%2C+Melody&rft.aulast=Mills&rft.aufirst=Melody&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The Role Of B. Burgdorferi Outer Membrane Protein BBA03 In Tick Transmission T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312911102; 6038614 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Bestor, A AU - Rego, R AU - Stewart, P AU - Rosa, P Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Membranes KW - outer membrane proteins KW - Ixodidae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312911102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=The+Role+Of+B.+Burgdorferi+Outer+Membrane+Protein+BBA03+In+Tick+Transmission&rft.au=Bestor%2C+A%3BRego%2C+R%3BStewart%2C+P%3BRosa%2C+P&rft.aulast=Bestor&rft.aufirst=A&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Analysis of the Kinetics of DNA Release from Candida albicans and Aspergillus fumigatus by Quantitative Real-Time PCR T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312908011; 6038385 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Wubhen, H AU - Beveridge, C AU - Kasai, M AU - Petraitiene, R AU - Petraitis, V AU - Bacher, J AU - Walsh, T Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Kinetics KW - Polymerase chain reaction KW - Insecticides KW - Nucleotide sequence KW - Aspergillus fumigatus KW - Candida albicans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312908011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Analysis+of+the+Kinetics+of+DNA+Release+from+Candida+albicans+and+Aspergillus+fumigatus+by+Quantitative+Real-Time+PCR&rft.au=Wubhen%2C+H%3BBeveridge%2C+C%3BKasai%2C+M%3BPetraitiene%2C+R%3BPetraitis%2C+V%3BBacher%2C+J%3BWalsh%2C+T&rft.aulast=Wubhen&rft.aufirst=H&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - 'Hyper-Replicating' Salmonella Mask the Requirement for SPI2 Effectors in Epithelial Cells T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312899477; 6037954 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Malik-Kale, P AU - Winfree, S AU - Steele-Mortimer, O Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Epithelial cells KW - Anadromous species KW - Salmonella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312899477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=%27Hyper-Replicating%27+Salmonella+Mask+the+Requirement+for+SPI2+Effectors+in+Epithelial+Cells&rft.au=Malik-Kale%2C+P%3BWinfree%2C+S%3BSteele-Mortimer%2C+O&rft.aulast=Malik-Kale&rft.aufirst=P&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Heat shock protein 90 from Escherichia coli collaborates with the DnaK chaperone system in client protein remodeling AN - 907156376; 14894834 AB - Molecular chaperones are proteins that assist the folding, unfolding, and remodeling of other proteins. In eukaryotes, heat shock protein 90 (Hsp90) proteins are essential ATP-dependent molecular chaperones that remodel and activate hundreds of client proteins with the assistance of cochaperones. In Escherichia coli, the activity of the Hsp90 homolog, HtpG, has remained elusive. To explore the mechanism of action of E. coli Hsp90, we used in vitro protein reactivation assays. We found that E. coli Hsp90 promotes reactivation of heat-inactivated luciferase in a reaction that requires the prokaryotic Hsp70 chaperone system, known as the DnaK system. An Hsp90 ATPase inhibitor, geldanamycin, inhibits luciferase reactivation demonstrating the importance of the ATP-dependent chaperone activity of E. coli Hsp90 during client protein remodeling. Reactivation also depends upon the ATP-dependent chaperone activity of the DnaK system. Our results suggest that the DnaK system acts first on the client protein, and then E. coli Hsp90 and the DnaK system collaborate synergistically to complete remodeling of the client protein. Results indicate that E. coli Hsp90 and DnaK interact in vivo and in vitro, providing additional evidence to suggest that E. coli Hsp90 and the DnaK system function together. JF - Proceedings of the National Academy of Sciences, USA AU - Genest, Olivier AU - Hoskins, Joel R AU - Camberg, Jodi L AU - Doyle, Shannon M AU - Wickner, Sue AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2011/05/17/ PY - 2011 DA - 2011 May 17 SP - 8206 EP - 8211 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 108 IS - 20 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology KW - Hsp90 protein KW - Heat shock proteins KW - Adenosinetriphosphatase KW - Protein folding KW - Hsp70 protein KW - Escherichia coli KW - DnaK protein KW - geldanamycin KW - Chaperones KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907156376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Heat+shock+protein+90+from+Escherichia+coli+collaborates+with+the+DnaK+chaperone+system+in+client+protein+remodeling&rft.au=Genest%2C+Olivier%3BHoskins%2C+Joel+R%3BCamberg%2C+Jodi+L%3BDoyle%2C+Shannon+M%3BWickner%2C+Sue&rft.aulast=Genest&rft.aufirst=Olivier&rft.date=2011-05-17&rft.volume=108&rft.issue=20&rft.spage=8206&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Hsp90 protein; Heat shock proteins; Adenosinetriphosphatase; Hsp70 protein; Protein folding; DnaK protein; geldanamycin; Chaperones; Escherichia coli ER - TY - JOUR T1 - A formal MIM specification and tools for the common exchange of MIM diagrams: an XML-Based format, an API, and a validation method AN - 883029851; 15090129 AB - The Molecular Interaction Map (MIM) notation offers a standard set of symbols and rules on their usage for the depiction of cellular signaling network diagrams. Such diagrams are essential for disseminating biological information in a concise manner. A lack of software tools for the notation restricts wider usage of the notation. Development of software is facilitated by a more detailed specification regarding software requirements than has previously existed for the MIM notation. A formal implementation of the MIM notation was developed based on a core set of previously defined glyphs. This implementation provides a detailed specification of the properties of the elements of the MIM notation. Building upon this specification, a machine-readable format is provided as a standardized mechanism for the storage and exchange of MIM diagrams. This new format is accompanied by a Java-based application programming interface to help software developers to integrate MIM support into software projects. A validation mechanism is also provided to determine whether MIM datasets are in accordance with syntax rules provided by the new specification. The work presented here provides key foundational components to promote software development for the MIM notation. These components will speed up the development of interoperable tools supporting the MIM notation and will aid in the translation of data stored in MIM diagrams to other standardized formats. Several projects utilizing this implementation of the notation are outlined herein. The MIM specification is available as an additional file to this publication. Source code, libraries, documentation, and examples are available at http://discover.nci.nih.gov/mim. JF - BMC Bioinformatics AU - Luna, Augustin AU - Karac, Evrim I AU - Sunshine, Margot AU - Chang, Lucas AU - Nussinov, Ruth AU - Aladjem, Mirit I AU - Kohn, Kurt W AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA Y1 - 2011/05/17/ PY - 2011 DA - 2011 May 17 SP - 167 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 12 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Translation KW - software KW - Data processing KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883029851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=A+formal+MIM+specification+and+tools+for+the+common+exchange+of+MIM+diagrams%3A+an+XML-Based+format%2C+an+API%2C+and+a+validation+method&rft.au=Luna%2C+Augustin%3BKarac%2C+Evrim+I%3BSunshine%2C+Margot%3BChang%2C+Lucas%3BNussinov%2C+Ruth%3BAladjem%2C+Mirit+I%3BKohn%2C+Kurt+W&rft.aulast=Luna&rft.aufirst=Augustin&rft.date=2011-05-17&rft.volume=12&rft.issue=&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-12-167 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Translation; Computer programs; software; Data processing; Bioinformatics DO - http://dx.doi.org/10.1186/1471-2105-12-167 ER - TY - JOUR T1 - Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death AN - 923203480; 14783152 AB - Ischemia/reperfusion (I/R) is a pivotal mechanism of liver damage after liver transplantation or hepatic surgery. We have investigated the effects of cannabidiol (CBD), the nonpsychotropic constituent of marijuana, in a mouse model of hepatic I/R injury. I/R triggered time-dependent increases/changes in markers of liver injury (serum transaminases), hepatic oxidative/nitrative stress (4-hydroxy-2-nonenal, nitrotyrosine content/staining, and gp91phox and inducible nitric oxide synthase mRNA), mitochondrial dysfunction (decreased complex I activity), inflammation (tumor necrosis factor alpha (TNF- alpha ), cyclooxygenase 2, macrophage inflammatory protein-1 alpha /2, intercellular adhesion molecule 1 mRNA levels; tissue neutrophil infiltration; nuclear factor Kappa B (NF- Kappa B) activation), stress signaling (p38MAPK and JNK), and cell death (DNA fragmentation, PARP activity, and TUNEL). CBD significantly reduced the extent of liver inflammation, oxidative/nitrative stress, and cell death and also attenuated the bacterial endotoxin-triggered NF- Kappa B activation and TNF- alpha production in isolated Kupffer cells, likewise the adhesion molecule expression in primary human liver sinusoidal endothelial cells stimulated with TNF- alpha and attachment of human neutrophils to the activated endothelium. These protective effects were preserved in CB sub(2 knockout mice and were not prevented by CB) sub(1)/2 antagonists in vitro. Thus, CBD may represent a novel, protective strategy against I/R injury by attenuating key inflammatory pathways and oxidative/nitrative tissue injury, independent of classical CB sub(1/2 receptors.) JF - Free Radical Biology and Medicine AU - Mukhopadhyay, Partha AU - Rajesh, Mohanraj AU - Horvath, Bela AU - Batkai, Sandor AU - Park, Ogyi AU - Tanchian, Galin AU - Gao, Rachel Y AU - Patel, Vivek AU - Wink, David A AU - Liaudet, Lucas AU - Hasko, Gyoergy AU - Mechoulam, Raphael AU - Pacher, Pal AD - Laboratory of Physiologic Studies, National Institutes of Health, Bethesda, MD 20892, USA, pacher@mail.nih.gov pacher@mail.nih.gov pacher@mail.nih.gov pacher@mail.nih.gov Y1 - 2011/05/15/ PY - 2011 DA - 2011 May 15 SP - 1368 EP - 1381 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 50 IS - 10 SN - 0891-5849, 0891-5849 KW - Microbiology Abstracts B: Bacteriology KW - Macrophages KW - nitrotyrosine KW - Injuries KW - Hepatocytes KW - Animal models KW - Mitochondria KW - Antagonists KW - transaminase KW - NF- Kappa B protein KW - Liver transplantation KW - Cell activation KW - Metastases KW - DNA fragmentation KW - Surgery KW - Allografts KW - Endothelium KW - Cannabis KW - Electron transport chain KW - c-Jun amino-terminal kinase KW - Leukocytes (neutrophilic) KW - Stress KW - Ischemia KW - Inflammation KW - mRNA KW - Reperfusion KW - Kupffer cells KW - Cell death KW - Liver KW - Tumor necrosis factor- alpha KW - Signal transduction KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/923203480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+Radical+Biology+and+Medicine&rft.atitle=Cannabidiol+protects+against+hepatic+ischemia%2Freperfusion+injury+by+attenuating+inflammatory+signaling+and+response%2C+oxidative%2Fnitrative+stress%2C+and+cell+death&rft.au=Mukhopadhyay%2C+Partha%3BRajesh%2C+Mohanraj%3BHorvath%2C+Bela%3BBatkai%2C+Sandor%3BPark%2C+Ogyi%3BTanchian%2C+Galin%3BGao%2C+Rachel+Y%3BPatel%2C+Vivek%3BWink%2C+David+A%3BLiaudet%2C+Lucas%3BHasko%2C+Gyoergy%3BMechoulam%2C+Raphael%3BPacher%2C+Pal&rft.aulast=Mukhopadhyay&rft.aufirst=Partha&rft.date=2011-05-15&rft.volume=50&rft.issue=10&rft.spage=1368&rft.isbn=&rft.btitle=&rft.title=Free+Radical+Biology+and+Medicine&rft.issn=08915849&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2011.02.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Macrophages; nitrotyrosine; Injuries; Hepatocytes; Animal models; Mitochondria; transaminase; Antagonists; Cell activation; Liver transplantation; NF- Kappa B protein; Metastases; DNA fragmentation; Surgery; Endothelium; Allografts; Cannabis; Electron transport chain; c-Jun amino-terminal kinase; Leukocytes (neutrophilic); Stress; Ischemia; mRNA; Inflammation; Reperfusion; Kupffer cells; Cell death; Liver; Tumor necrosis factor- alpha; Signal transduction DO - http://dx.doi.org/10.1016/j.freeradbiomed.2011.02.021 ER - TY - JOUR T1 - Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk) AN - 874193405; 14974603 AB - Continued examination of substituted 6-arylquinazolin-4-amines as Clk4 inhibitors resulted in selective inhibitors of Clk1, Clk4, Dyrk1A and Dyrk1B. Several of the most potent inhibitors were validated as being highly selective within a comprehensive kinome scan. JF - Bioorganic and Medicinal Chemistry Letters AU - Rosenthal, Andrew S AU - Tanega, Cordelle AU - Shen, Min AU - Mott, Bryan T AU - Bougie, James M AU - Nguyen, Dac-Trung AU - Misteli, Tom AU - Auld, Douglas S AU - Maloney, David J AU - Thomas, Craig J AD - NIH Chemical Genomics Center, National Human Genome Research Institute, NIH, 9800 Medical Center Drive, MSC 3370, Bethesda, MD 20892-3370, USA, craigt@mail.nih.gov Y1 - 2011/05/15/ PY - 2011 DA - 2011 May 15 SP - 3152 EP - 3158 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 21 IS - 10 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - Diseases KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874193405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Potent+and+selective+small+molecule+inhibitors+of+specific+isoforms+of+Cdc2-like+kinases+%28Clk%29+and+dual+specificity+tyrosine-phosphorylation-regulated+kinases+%28Dyrk%29&rft.au=Rosenthal%2C+Andrew+S%3BTanega%2C+Cordelle%3BShen%2C+Min%3BMott%2C+Bryan+T%3BBougie%2C+James+M%3BNguyen%2C+Dac-Trung%3BMisteli%2C+Tom%3BAuld%2C+Douglas+S%3BMaloney%2C+David+J%3BThomas%2C+Craig+J&rft.aulast=Rosenthal&rft.aufirst=Andrew&rft.date=2011-05-15&rft.volume=21&rft.issue=10&rft.spage=3152&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2011.02.114 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Diseases DO - http://dx.doi.org/10.1016/j.bmcl.2011.02.114 ER - TY - JOUR T1 - Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors AN - 874182036; 14974568 AB - New tricyclic HIV-1 integrase (IN) inhibitors were prepared that combined structural features of bicyclic pyrimidinones with recently disclosed 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones. This combination resulted in the introduction of a nitrogen into the aryl ring and the addition of a fused third ring to our previously described inhibitors. The resulting analogues showed low micromolar inhibitory potency in in vitro HIV-1 integrase assays, with good selectivity for strand transfer relative to 3'-processing. JF - Bioorganic and Medicinal Chemistry Letters AU - Zhao, Xue Zhi AU - Maddali, Kasthuraiah AU - Metifiot, Mathieu AU - Smith, Steven J AU - Vu, BChristie AU - Marchand, Christophe AU - Hughes, Stephen H AU - Pommier, Yves AU - Burke, Terrence R AD - Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702, United States Y1 - 2011/05/15/ PY - 2011 DA - 2011 May 15 SP - 2986 EP - 2990 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 21 IS - 10 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - Human immunodeficiency virus 1 KW - Integrase KW - Nitrogen KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874182036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Development+of+tricyclic+hydroxy-1H-pyrrolopyridine-trione+containing+HIV-1+integrase+inhibitors&rft.au=Zhao%2C+Xue+Zhi%3BMaddali%2C+Kasthuraiah%3BMetifiot%2C+Mathieu%3BSmith%2C+Steven+J%3BVu%2C+BChristie%3BMarchand%2C+Christophe%3BHughes%2C+Stephen+H%3BPommier%2C+Yves%3BBurke%2C+Terrence+R&rft.aulast=Zhao&rft.aufirst=Xue&rft.date=2011-05-15&rft.volume=21&rft.issue=10&rft.spage=2986&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2011.03.047 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Nitrogen; Integrase; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.bmcl.2011.03.047 ER - TY - JOUR T1 - Kernel regression for fMRI pattern prediction AN - 864958247; 14693807 AB - This paper introduces two kernel-based regression schemes to decode or predict brain states from functional brain scans as part of the Pittsburgh Brain Activity Interpretation Competition (PBAIC) 2007, in which our team was awarded first place. Our procedure involved image realignment, spatial smoothing, detrending of low-frequency drifts, and application of multivariate linear and non-linear kernel regression methods: namely kernel ridge regression (KRR) and relevance vector regression (RVR). RVR is based on a Bayesian framework, which automatically determines a sparse solution through maximization of marginal likelihood. KRR is the dual-form formulation of ridge regression, which solves regression problems with high dimensional data in a computationally efficient way. Feature selection based on prior knowledge about human brain function was also used. Post-processing by constrained deconvolution and re-convolution was used to furnish the prediction. This paper also contains a detailed description of how prior knowledge was used to fine tune predictions of specific "feature ratings," which we believe is one of the key factors in our prediction accuracy. The impact of pre-processing was also evaluated, demonstrating that different pre-processing may lead to significantly different accuracies. Although the original work was aimed at the PBAIC, many techniques described in this paper can be generally applied to any fMRI decoding works to increase the prediction accuracy. JF - NeuroImage AU - Chu, Carlton AU - Ni, Yizhao AU - Tan, Geoffrey AU - Saunders, Craig J AU - Ashburner, John AD - Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK, chuc2@mail.nih.gov Y1 - 2011/05/15/ PY - 2011 DA - 2011 May 15 SP - 662 EP - 673 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 56 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Kernel methods KW - Machine learning KW - Kernel ridge regression (KRR) KW - fMRI prediction KW - Automatic relevance determination (ARD) KW - Relevance vector machines (RVM) KW - Regression KW - Multivariate KW - Brain mapping KW - Neuroimaging KW - Data processing KW - Bayesian analysis KW - Drift KW - Functional magnetic resonance imaging KW - Kernels KW - Competition KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864958247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Kernel+regression+for+fMRI+pattern+prediction&rft.au=Chu%2C+Carlton%3BNi%2C+Yizhao%3BTan%2C+Geoffrey%3BSaunders%2C+Craig+J%3BAshburner%2C+John&rft.aulast=Chu&rft.aufirst=Carlton&rft.date=2011-05-15&rft.volume=56&rft.issue=2&rft.spage=662&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.03.058 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Brain mapping; Neuroimaging; Data processing; Drift; Bayesian analysis; Functional magnetic resonance imaging; Kernels; Competition DO - http://dx.doi.org/10.1016/j.neuroimage.2010.03.058 ER - TY - JOUR T1 - Effect of CCS on the accumulation of FALS SOD1 mutant-containing aggregates and on mitochondrial translocation of SOD1 mutants: Implication of a free radical hypothesis AN - 1356926054; 14694249 AB - Missense mutations of SOD1 are linked to familial amyotrophic lateral sclerosis (FALS) through a yet-to-be identified toxic-gain-of-function. One of the proposed mechanisms involves enhanced aggregate formation. However, a recent study showed that dual transgenic mice overexpressing both G93A and CCS copper chaperone (G93A/CCS) exhibit no SOD1-positive aggregates yet show accelerated FALS symptoms with enhanced mitochondrial pathology compared to G93A mice. Using a dicistronic mRNA to simultaneously generate hSOD1 mutants, G93A, A4V and G85R, and hCCS in AAV293 cells, we revealed: (i) CCS is degraded primarily via a macroautophagy pathway. It forms a stable heterodimer with inactive G85R, and via its novel copper chaperone-independent molecular chaperone activity facilitates G85R degradation via a macroautophagy-mediated pathway. For active G93A and A4V, CCS catalyzes their maturation to form active and soluble homodimers. (ii) CCS reduces, under non-oxidative conditions, yet facilitates in the presence of H sub(2O) sub(2), mitochondrial translocation of inactive SOD1 mutants. These results, together with previous reports showing FALS SOD1 mutants enhanced free radical-generating activity, provide a mechanistic explanation for the observations with G93A/CCS dual transgenic mice and suggest that free radical generation by FALS SOD1, enhanced by CCS, may, in part, be responsible for the FALS SOD1 mutant-linked aggregation, mitochondrial translocation, and degradation. JF - Archives of Biochemistry and Biophysics AU - Kim, Ha Kun AU - Chung, Youn Wook AU - Chock, PBoon AU - Yim, Moon B AD - Laboratory of Biochemistry, NHLBI, National Institutes of Health, Building 50, Room 2152, MSC-8012, Bethesda, MD 20892-8012, USA Y1 - 2011/05/15/ PY - 2011 DA - 2011 May 15 SP - 177 EP - 185 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 509 IS - 2 SN - 0003-9861, 0003-9861 KW - Toxicology Abstracts KW - Missense mutation KW - Amyotrophic lateral sclerosis KW - Superoxide dismutase KW - Hydrogen peroxide KW - Free radicals KW - Mitochondria KW - Chaperones KW - Copper KW - Transgenic mice KW - Translocation KW - mRNA KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1356926054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Biochemistry+and+Biophysics&rft.atitle=Effect+of+CCS+on+the+accumulation+of+FALS+SOD1+mutant-containing+aggregates+and+on+mitochondrial+translocation+of+SOD1+mutants%3A+Implication+of+a+free+radical+hypothesis&rft.au=Kim%2C+Ha+Kun%3BChung%2C+Youn+Wook%3BChock%2C+PBoon%3BYim%2C+Moon+B&rft.aulast=Kim&rft.aufirst=Ha&rft.date=2011-05-15&rft.volume=509&rft.issue=2&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Archives+of+Biochemistry+and+Biophysics&rft.issn=00039861&rft_id=info:doi/10.1016%2Fj.abb.2011.02.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Last updated - 2013-06-14 N1 - SubjectsTermNotLitGenreText - Missense mutation; Amyotrophic lateral sclerosis; Hydrogen peroxide; Superoxide dismutase; Free radicals; Mitochondria; Chaperones; Copper; Transgenic mice; Translocation; mRNA DO - http://dx.doi.org/10.1016/j.abb.2011.02.014 ER - TY - JOUR T1 - Evidence That Serum Levels of the Soluble Receptor for Advanced Glycation End Products Are Inversely Associated with Pancreatic Cancer Risk: A Prospective Study AN - 1034811903; 14872471 AB - Cigarette smoking, obesity, type 2 diabetes, and, to a lesser extent, meat cooked at high temperatures are associated with pancreatic cancer. Cigarette smoke and foods cooked at higher temperatures are major environmental sources of advanced glycation end products (AGE). AGEs accumulate during hyperglycemia and elicit oxidative stress and inflammation through interaction with the receptor for AGEs (RAGE). Soluble RAGE (sRAGE) acts as an anti-inflammatory factor to neutralize AGEs and block the effects mediated by RAGE. In this study, we investigated the associations of prediagnostic measures of N epsilon -(carboxymethyl)-lysine (CML)-AGE and sRAGE with pancreatic cancer in a case-cohort study within a cohort of 29,133 Finnish male smokers. Serum samples and exposure information were collected at baseline (1985-1988). We measured CML-AGE, sRAGE, glucose, and insulin concentrations in fasting serum from 255 incident pancreatic cancer cases that arose through April 2005 and from 485 randomly sampled subcohort participants. Weighted Cox proportional hazard regression models were used to calculate relative risks (RR) and 95% CI, adjusted for age, years of smoking, and body mass index. CML-AGE and sRAGE were mutually adjusted. CML-AGE levels were not associated with pancreatic cancer [fifth compared with first quintile, RR (95% CI): 0.68 (0.38-1.22), Ptrend = 0.27]. In contrast, sRAGE levels were inversely associated with pancreatic cancer [fifth compared with first quintile, RR (95% CI): 0.46 (0.23-0.73), Ptrend = 0.002]. Further adjustment for glucose or insulin levels did not change the observed associations. Our findings suggest that sRAGE is inversely associated with pancreatic cancer risk among Finnish male smokers. Cancer Res; 71(10); 3582-9. [copy ]2011 AACR. JF - Cancer Research AU - Jiao, Li AU - Weinstein, Stephanie J AU - Albanes, Demetrius AU - Taylor, Philip R AU - Graubard, Barry I AU - Virtamo, Jarmo AU - Stolzenberg-Solomon, Rachael Z AD - Authors' Affiliations: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland and Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland Y1 - 2011/05/15/ PY - 2011 DA - 2011 May 15 SP - 3582 EP - 3589 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 71 IS - 10 SN - 0008-5472, 0008-5472 KW - Health & Safety Science Abstracts KW - Age KW - Cancer KW - Cigarettes KW - Diabetes mellitus KW - Insulin KW - Meat KW - Obesity KW - Oxidative stress KW - Pancreatic cancer KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034811903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Evidence+That+Serum+Levels+of+the+Soluble+Receptor+for+Advanced+Glycation+End+Products+Are+Inversely+Associated+with+Pancreatic+Cancer+Risk%3A+A+Prospective+Study&rft.au=Jiao%2C+Li%3BWeinstein%2C+Stephanie+J%3BAlbanes%2C+Demetrius%3BTaylor%2C+Philip+R%3BGraubard%2C+Barry+I%3BVirtamo%2C+Jarmo%3BStolzenberg-Solomon%2C+Rachael+Z&rft.aulast=Jiao&rft.aufirst=Li&rft.date=2011-05-15&rft.volume=71&rft.issue=10&rft.spage=3582&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Last updated - 2012-08-24 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Meat; Obesity; Age; Cigarettes; Oxidative stress; Pancreatic cancer; Insulin; Cancer ER - TY - CPAPER T1 - Gene transfer and hematopoietic stem cell transplantation in rhesus macaques: lessons learned T2 - 98th Annual Meeting of the American Association of Immunologists (AAI 2011) AN - 1313070284; 6077627 JF - 98th Annual Meeting of the American Association of Immunologists (AAI 2011) AU - Donahue, Robert Y1 - 2011/05/13/ PY - 2011 DA - 2011 May 13 KW - stem cells KW - Gene transfer KW - stem cell transplantation KW - Macaca mulatta UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313070284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=98th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28AAI+2011%29&rft.atitle=Gene+transfer+and+hematopoietic+stem+cell+transplantation+in+rhesus+macaques%3A+lessons+learned&rft.au=Donahue%2C+Robert&rft.aulast=Donahue&rft.aufirst=Robert&rft.date=2011-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=98th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28AAI+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2011.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - From faculty to fed: moving from the bench to a desk T2 - 98th Annual Meeting of the American Association of Immunologists (AAI 2011) AN - 1313069885; 6077620 JF - 98th Annual Meeting of the American Association of Immunologists (AAI 2011) AU - Plaeger, Susan Y1 - 2011/05/13/ PY - 2011 DA - 2011 May 13 KW - Epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313069885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=98th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28AAI+2011%29&rft.atitle=From+faculty+to+fed%3A+moving+from+the+bench+to+a+desk&rft.au=Plaeger%2C+Susan&rft.aulast=Plaeger&rft.aufirst=Susan&rft.date=2011-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=98th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28AAI+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2011.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Chemokine regulation of leukocyte egress from the bone marrow: insights from the clinic T2 - 98th Annual Meeting of the American Association of Immunologists (AAI 2011) AN - 1313029413; 6077607 JF - 98th Annual Meeting of the American Association of Immunologists (AAI 2011) AU - Murphy, Philip Y1 - 2011/05/13/ PY - 2011 DA - 2011 May 13 KW - Bone marrow KW - Leukocytes KW - Chemokines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313029413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=98th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28AAI+2011%29&rft.atitle=Chemokine+regulation+of+leukocyte+egress+from+the+bone+marrow%3A+insights+from+the+clinic&rft.au=Murphy%2C+Philip&rft.aulast=Murphy&rft.aufirst=Philip&rft.date=2011-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=98th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28AAI+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2011.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Refining the allogeneic graft-versus-leukemia effect T2 - 98th Annual Meeting of the American Association of Immunologists (AAI 2011) AN - 1313008619; 6077634 JF - 98th Annual Meeting of the American Association of Immunologists (AAI 2011) AU - Barrett, A Y1 - 2011/05/13/ PY - 2011 DA - 2011 May 13 KW - Graft-versus-leukemia reaction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313008619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=98th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28AAI+2011%29&rft.atitle=Refining+the+allogeneic+graft-versus-leukemia+effect&rft.au=Barrett%2C+A&rft.aulast=Barrett&rft.aufirst=A&rft.date=2011-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=98th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28AAI+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2011.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - argeting dendritic cells in vivo with protein vaccines to elicit T cell immunity T2 - 98th Annual Meeting of the American Association of Immunologists (AAI 2011) AN - 1313008279; 6077568 JF - 98th Annual Meeting of the American Association of Immunologists (AAI 2011) AU - Seder, Robert Y1 - 2011/05/13/ PY - 2011 DA - 2011 May 13 KW - vaccines KW - Vaccines KW - Dendritic cells KW - Lymphocytes T KW - Immunity KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313008279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=98th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28AAI+2011%29&rft.atitle=argeting+dendritic+cells+in+vivo+with+protein+vaccines+to+elicit+T+cell+immunity&rft.au=Seder%2C+Robert&rft.aulast=Seder&rft.aufirst=Robert&rft.date=2011-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=98th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28AAI+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2011.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Microbial control of tissue homeostasis T2 - 98th Annual Meeting of the American Association of Immunologists (AAI 2011) AN - 1313005855; 6077645 JF - 98th Annual Meeting of the American Association of Immunologists (AAI 2011) AU - Belkaid, Yasmine Y1 - 2011/05/13/ PY - 2011 DA - 2011 May 13 KW - Homeostasis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313005855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=98th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28AAI+2011%29&rft.atitle=Microbial+control+of+tissue+homeostasis&rft.au=Belkaid%2C+Yasmine&rft.aulast=Belkaid&rft.aufirst=Yasmine&rft.date=2011-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=98th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28AAI+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2011.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - MHC class II trafficking and function in dendritic cells T2 - 98th Annual Meeting of the American Association of Immunologists (AAI 2011) AN - 1312933651; 6077596 JF - 98th Annual Meeting of the American Association of Immunologists (AAI 2011) AU - Roche, Paul Y1 - 2011/05/13/ PY - 2011 DA - 2011 May 13 KW - Trafficking KW - Dendritic cells KW - Major histocompatibility complex UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312933651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=98th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28AAI+2011%29&rft.atitle=MHC+class+II+trafficking+and+function+in+dendritic+cells&rft.au=Roche%2C+Paul&rft.aulast=Roche&rft.aufirst=Paul&rft.date=2011-05-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=98th+Annual+Meeting+of+the+American+Association+of+Immunologists+%28AAI+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2011.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Personalized estimates of breast cancer risk in clinical practice and public health AN - 1017970787; 16691041 AB - This paper defines absolute risk and some of its properties, and presents applications in breast cancer counseling and prevention. For counseling, estimates of absolute risk give useful perspective and can be used in management decisions that require weighing risks and benefits, such as whether or not to take tamoxifen to prevent breast cancer. Absolute risk models are also useful in designing intervention trials to prevent breast cancer and in assessing the potential reductions in absolute risk of disease that might result from reducing exposures that are associated with breast cancer. In these applications, it is important that the risk model be well calibrated, namely that it accurately predicts the numbers of women who will develop breast cancer in various subsets of the population. Absolute risk models are also needed to implement a 'high risk' prevention strategy that identifies a high-risk subset of the population and focuses intervention efforts on that subset. The limitations of the high-risk strategy are discussed, including the need for risk models with high discriminatory accuracy, and the need for less toxic interventions that can reduce the threshold of risk above which the intervention provides a net benefit. I also discuss the potential use of risk models in allocating prevention resources under cost constraints. High discriminatory accuracy of the risk model, in addition to good calibration, is desirable in this application, and the risk assessment should not be expensive in comparison with the intervention. Published in 2011 by John Wiley & Sons, Ltd. JF - Statistics in Medicine AU - Gail, Mitchell H Y1 - 2011/05/10/ PY - 2011 DA - 2011 May 10 SP - 1090 EP - 1104 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 30 IS - 10 SN - 1097-0258, 1097-0258 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Breast cancer KW - Cancer KW - Intervention KW - Prevention KW - Public health KW - Risk assessment KW - intervention KW - prevention KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017970787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistics+in+Medicine&rft.atitle=Personalized+estimates+of+breast+cancer+risk+in+clinical+practice+and+public+health&rft.au=Gail%2C+Mitchell+H&rft.aulast=Gail&rft.aufirst=Mitchell&rft.date=2011-05-10&rft.volume=30&rft.issue=10&rft.spage=1090&rft.isbn=&rft.btitle=&rft.title=Statistics+in+Medicine&rft.issn=10970258&rft_id=info:doi/10.1002%2Fsim.4187 L2 - http://onlinelibrary.wiley.com/doi/10.1002/sim.4187/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Risk assessment; Prevention; intervention; prevention; Intervention; Breast cancer; Cancer; Public health DO - http://dx.doi.org/10.1002/sim.4187 ER - TY - JOUR T1 - Long term stability of a recombinant Plasmodium falciparum AMA1 malaria vaccine adjuvanted with Montanide registered ISA 720 and stabilized with glycine AN - 874192442; 14984171 AB - Plasmodium falciparum apical membrane antigen 1 (AMA1) is an asexual blood-stage vaccine candidate against the malaria parasite. AMA1-C1/ISA720 refers to a mixture of recombinant AMA1 proteins representing the FVO and 3D7 alleles in 1:1 mass ratio, formulated with Montanide registered ISA 720 as a water-in oil emulsion. In order to develop the AMA1-C1/ISA720 vaccine for human use, it was important to determine the shelf life of this formulation. Previously it was found 267 mM glycine stabilized the proteins in Montanide registered ISA 720 formulations for a short period of time at 2-8 [deg]C [25]. We now test the long term stability of AMA1-C1 at 10 and 40 [micro]g/mL formulated with Montanide registered ISA 720 with 50 mM glycine as a stabilizer. Stability of AMA1-C1/ISA720 at different time points following formulation (0, 5, 12 or 18 months) was evaluated by determining the mean particle size (diameter of the mean droplet volume), total protein content by a Modified Lowry assay, identity and integrity using western blot and SDS-PAGE. Our results showed that the mean particle size of these emulsions increased over time, whereas protein content, as determined by an ELISA method using a monoclonal antibody against penta-his, decreased over time. For the 10 [micro]g/mL AMA1-C1/ISA720 vaccine, the protein content was 6.5 +/- 2.2 [micro]g/mL, and for the 40 [micro]g/mL AMA1-C1/ISA720 vaccine, the protein content was only 8.2 +/- 2.3 [micro]g/mL after 18 months of storage at 2-8 [deg]C. These results suggest that the integrity of the protein was affected by long-term storage. The results of the present study indicate that the AMA1-C1/ISA720 emulsion was unstable after 12 months of storage, after which AMA1-C1 proteins were partially degraded. JF - Vaccine AU - Zhu, Daming AU - McClellan, Holly AU - Dai, Weili AU - Gebregeorgis, Elizabeth AU - Kidwell, Mary Anne AU - Aebig, Joan AU - Rausch, Kelly M AU - Martin, Laura B AU - Ellis, Ruth D AU - Miller, Louis AU - Wu, Yimin AD - Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Disease, National Institutes of Health, 5640 Fishers Lane, Rockville, MD 20852, USA, dzhu@niaid.nih.gov dzhu@niaid.nih.gov Y1 - 2011/05/09/ PY - 2011 DA - 2011 May 09 SP - 3640 EP - 3645 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 29 IS - 20 SN - 0264-410X, 0264-410X KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Montanide[super][registered] ISA 720 KW - AMA1 KW - Malaria KW - Vaccine KW - Apical membrane antigen 1 KW - Particle size KW - Western blotting KW - Parasites KW - Enzyme-linked immunosorbent assay KW - Monoclonal antibodies KW - Glycine KW - Storage life KW - Disease control KW - Plasmodium falciparum KW - Shelf life KW - Emulsions KW - AmA1 protein KW - Public health KW - Oil KW - Recombinants KW - Lowry assay KW - Fish diseases KW - Vaccines KW - F 06905:Vaccines KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874192442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Long+term+stability+of+a+recombinant+Plasmodium+falciparum+AMA1+malaria+vaccine+adjuvanted+with+Montanide+registered+ISA+720+and+stabilized+with+glycine&rft.au=Zhu%2C+Daming%3BMcClellan%2C+Holly%3BDai%2C+Weili%3BGebregeorgis%2C+Elizabeth%3BKidwell%2C+Mary+Anne%3BAebig%2C+Joan%3BRausch%2C+Kelly+M%3BMartin%2C+Laura+B%3BEllis%2C+Ruth+D%3BMiller%2C+Louis%3BWu%2C+Yimin&rft.aulast=Zhu&rft.aufirst=Daming&rft.date=2011-05-09&rft.volume=29&rft.issue=20&rft.spage=3640&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2011.03.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Particle size; Recombinants; Parasites; Fish diseases; Storage life; Disease control; Vaccines; Emulsions; Public health; Apical membrane antigen 1; Western blotting; Enzyme-linked immunosorbent assay; Glycine; Monoclonal antibodies; Malaria; Shelf life; AmA1 protein; Oil; Lowry assay; Plasmodium falciparum DO - http://dx.doi.org/10.1016/j.vaccine.2011.03.015 ER - TY - JOUR T1 - Mismatch repair-independent tandem repeat sequence instability resulting from ribonucleotide incorporation by DNA polymerase ε. AN - 864195380; 21414850 AB - During DNA synthesis in vitro using dNTP and rNTP concentrations present in vivo, yeast replicative DNA polymerases α, δ and ɛ (Pols α, δ and ɛ) stably incorporate rNTPs into DNA. rNTPs are also incorporated during replication in vivo, and they are repaired in an RNase H2-dependent manner. In strains encoding a mutator allele of Pol ɛ (pol2-M644G), failure to remove rNMPs from DNA due to deletion of the RNH201 gene encoding the catalytic subunit of RNase H2, results in deletion of 2-5 base pairs in short repetitive sequences. Deletion rates depend on the orientation of the reporter gene relative to a nearby replication origin, suggesting that mutations result from rNMPs incorporated during replication. Here we demonstrate that 2-5 base pair deletion mutagenesis also strongly increases in rnh201Δ strains encoding wild type DNA polymerases. As in the pol2-M644G strains, the deletions occur at repetitive sequences and are orientation-dependent, suggesting that mismatches involving misaligned strands arise that could be subject to mismatch repair. Unexpectedly however, 2-5 base pair deletion rates resulting from loss of RNH201 in the pol2-M644G strain are unaffected by concomitant loss of MSH3, MSH6, or both. It could be that the mismatch repair machinery is unable to repair mismatches resulting from unrepaired rNMPs incorporated into DNA by M644G Pol ɛ, but this possibility is belied by the observation that Msh2-Msh6 can bind to a ribonucleotide-containing mismatch. Alternatively, following incorporation of rNMPs by M644G Pol ɛ during replication, the conversion of unrepaired rNMPs into mutations may occur outside the context of replication, e.g., during the repair of nicks resulting from rNMPs in DNA. The results make interesting predictions that can be tested. Published by Elsevier B.V. JF - DNA repair AU - Clark, Alan B AU - Lujan, Scott A AU - Kissling, Grace E AU - Kunkel, Thomas A AD - Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States. Y1 - 2011/05/05/ PY - 2011 DA - 2011 May 05 SP - 476 EP - 482 VL - 10 IS - 5 KW - DNA-Binding Proteins KW - 0 KW - MSH6 protein, S cerevisiae KW - Ribonucleotides KW - Saccharomyces cerevisiae Proteins KW - URA3 protein, S cerevisiae KW - DNA Polymerase II KW - EC 2.7.7.- KW - MSH2 protein, S cerevisiae KW - EC 3.6.1.3 KW - MutS Homolog 2 Protein KW - Index Medicus KW - Saccharomyces cerevisiae Proteins -- metabolism KW - Base Sequence KW - Saccharomyces cerevisiae Proteins -- genetics KW - Molecular Sequence Data KW - MutS Homolog 2 Protein -- metabolism KW - Mutation KW - DNA-Binding Proteins -- metabolism KW - Saccharomyces cerevisiae -- genetics KW - DNA Mismatch Repair -- genetics KW - Saccharomyces cerevisiae -- metabolism KW - DNA Polymerase II -- metabolism KW - Ribonucleotides -- metabolism KW - Genomic Instability -- genetics KW - DNA Polymerase II -- genetics KW - Tandem Repeat Sequences -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864195380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=Mismatch+repair-independent+tandem+repeat+sequence+instability+resulting+from+ribonucleotide+incorporation+by+DNA+polymerase+%CE%B5.&rft.au=Clark%2C+Alan+B%3BLujan%2C+Scott+A%3BKissling%2C+Grace+E%3BKunkel%2C+Thomas+A&rft.aulast=Clark&rft.aufirst=Alan&rft.date=2011-05-05&rft.volume=10&rft.issue=5&rft.spage=476&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=1568-7856&rft_id=info:doi/10.1016%2Fj.dnarep.2011.02.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-11 N1 - Date created - 2011-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 1999 Dec;19(12):8361-71 [10567561] Cell Cycle. 2010 Nov 15;9(22):4422-4 [21088478] Nucleic Acids Res. 2000 Nov 1;28(21):4356-63 [11058136] Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9954-9 [12119399] Cell. 2003 Feb 7;112(3):391-401 [12581528] Nucleic Acids Res. 2003 Jul 15;31(14):4129-37 [12853630] J Natl Cancer Inst. 2004 Feb 18;96(4):261-8 [14970275] Cold Spring Harb Symp Quant Biol. 1966;31:77-84 [5237214] J Mol Biol. 1994 Feb 11;236(1):275-85 [7508984] Mol Cell Biochem. 1994 Nov 9;140(1):1-22 [7877593] Genes Dev. 1996 Feb 15;10(4):407-20 [8600025] Annu Rev Biochem. 1996;65:101-33 [8811176] Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1619-22 [9050827] Mol Cell Biol. 1999 Apr;19(4):3177-83 [10082584] Yeast. 1999 Oct;15(14):1541-53 [10514571] J Biol Chem. 2004 Dec 24;279(52):53903-6 [15513922] Annu Rev Biochem. 2005;74:681-710 [15952900] Chem Rev. 2006 Feb;106(2):302-23 [16464007] Trends Biochem Sci. 2006 Apr;31(4):206-14 [16545956] Nat Genet. 2006 Aug;38(8):910-6 [16845400] Science. 2007 Jul 6;317(5834):127-30 [17615360] Mol Cell. 2008 Apr 25;30(2):137-44 [18439893] Mech Ageing Dev. 2008 Jul-Aug;129(7-8):391-407 [18406444] Clin Genet. 2009 Jul;76(1):1-18 [19659756] Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4949-54 [20194773] PLoS One. 2010;5(6):e11182 [20567595] J Biol Chem. 2010 Aug 6;285(32):24457-65 [20519499] Nat Chem Biol. 2010 Oct;6(10):774-81 [20729855] Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17674-9 [20876092] Nat Rev Genet. 2010 Nov;11(11):786-99 [20953213] Nucleic Acids Res. 2000 Sep 15;28(18):3649-56 [10982888] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.dnarep.2011.02.001 ER - TY - JOUR T1 - Modeling of the DNA-binding site of yeast Pms1 by mass spectrometry. AN - 864195371; 21354867 AB - Mismatch repair (MMR) corrects replication errors that would otherwise lead to mutations and, potentially, various forms of cancer. Among several proteins required for eukaryotic MMR, MutLα is a heterodimer comprised of Mlh1 and Pms1. The two proteins dimerize along their C-terminal domains (CTDs), and the CTD of Pms1 houses a latent endonuclease that is required for MMR. The highly conserved N-terminal domains (NTDs) independently bind DNA and possess ATPase active sites. Here we use two protein footprinting techniques, limited proteolysis and oxidative surface mapping, coupled with mass spectrometry to identify amino acids involved along the DNA-binding surface of the Pms1-NTD. Limited proteolysis experiments elucidated several basic residues that were protected in the presence of DNA, while oxidative surface mapping revealed one residue that is uniquely protected from oxidation. Furthermore, additional amino acids distributed throughout the Pms1-NTD were protected from oxidation either in the presence of a non-hydrolyzable analog of ATP or DNA, indicating that each ligand stabilizes the protein in a similar conformation. Based on the recently published X-ray crystal structure of yeast Pms1-NTD, a model of the Pms1-NTD/DNA complex was generated using the mass spectrometric data as constraints. The proposed model defines the DNA-binding interface along a positively charged groove of the Pms1-NTD and complements prior mutagenesis studies of Escherichia coli and eukaryotic MutL. Published by Elsevier B.V. JF - DNA repair AU - Schorzman, Allison N AU - Perera, Lalith AU - Cutalo-Patterson, Jenny M AU - Pedersen, Lars C AU - Pedersen, Lee G AU - Kunkel, Thomas A AU - Tomer, Kenneth B AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States. schorzmana@niehs.nih.gov Y1 - 2011/05/05/ PY - 2011 DA - 2011 May 05 SP - 454 EP - 465 VL - 10 IS - 5 KW - DNA-Binding Proteins KW - 0 KW - Fungal Proteins KW - Peptides KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Oxidation-Reduction KW - DNA Mismatch Repair -- genetics KW - Amino Acid Motifs KW - Molecular Sequence Data KW - Peptides -- metabolism KW - Amino Acid Sequence KW - Protein Structure, Tertiary KW - Protein Binding KW - Binding Sites KW - Fungal Proteins -- chemistry KW - Mass Spectrometry KW - Fungal Proteins -- metabolism KW - DNA-Binding Proteins -- chemistry KW - Models, Molecular KW - DNA -- metabolism KW - Yeasts -- genetics KW - Yeasts -- chemistry KW - Yeasts -- metabolism KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864195371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=Modeling+of+the+DNA-binding+site+of+yeast+Pms1+by+mass+spectrometry.&rft.au=Schorzman%2C+Allison+N%3BPerera%2C+Lalith%3BCutalo-Patterson%2C+Jenny+M%3BPedersen%2C+Lars+C%3BPedersen%2C+Lee+G%3BKunkel%2C+Thomas+A%3BTomer%2C+Kenneth+B&rft.aulast=Schorzman&rft.aufirst=Allison&rft.date=2011-05-05&rft.volume=10&rft.issue=5&rft.spage=454&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=1568-7856&rft_id=info:doi/10.1016%2Fj.dnarep.2011.01.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-11 N1 - Date created - 2011-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Anal Chem. 2005 Jul 15;77(14):4649-53 [16013884] DNA Repair (Amst). 2010 Apr 4;9(4):448-57 [20138591] J Mol Biol. 2005 Aug 26;351(4):895-909 [16024043] Anal Chem. 2005 Sep 15;77(18):5814-22 [16159110] J Am Soc Mass Spectrom. 2005 Dec;16(12):2057-63 [16263307] Chem Rev. 2006 Feb;106(2):302-23 [16464007] Annu Rev Biophys Biomol Struct. 2006;35:251-76 [16689636] Anal Chem. 2006 Jul 15;78(14):4885-93 [16841907] J Biol Chem. 2006 Oct 13;281(41):30305-9 [16905530] Biochemistry. 2006 Dec 26;45(51):15458-67 [17176067] Biophys J. 2007 Mar 1;92(5):1682-92 [17158574] J Synchrotron Radiat. 2007 May;14(Pt 3):233-43 [17435298] Mass Spectrom Rev. 2001 Nov-Dec;20(6):388-401 [11997945] Biol Chem. 2002 Jun;383(6):969-75 [12222686] Anal Biochem. 2003 Feb 15;313(2):216-25 [12605858] Anal Chem. 2003 Mar 1;75(5):1164-72 [12641237] Nucleic Acids Res. 2003 Apr 15;31(8):2025-34 [12682353] Annu Rev Microbiol. 2003;57:579-608 [14527292] Biochemistry. 2003 Nov 4;42(43):12447-54 [14580189] Mol Cell Proteomics. 2003 Oct;2(10):1120-32 [12966145] Anal Chem. 2004 Feb 1;76(3):672-83 [14750862] Anal Chem. 2004 Jul 1;76(13):3498-504 [15228316] EMBO J. 2004 Oct 27;23(21):4134-45 [15470502] Proc Natl Acad Sci U S A. 1986 Aug;83(15):5469-73 [3090544] Science. 1989 Jul 14;245(4914):160-4 [2665076] Methods Enzymol. 1990;186:545-9 [2172714] Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10578-82 [1961724] J Mol Biol. 1992 Sep 5;227(1):177-96 [1387915] Biochemistry. 1993 Mar 2;32(8):2104-10 [8383534] Curr Opin Genet Dev. 1995 Jun;5(3):382-95 [7549435] Methods Enzymol. 1995;262:217-32 [8594349] Mol Cell Biol. 1997 Aug;17(8):4465-73 [9234704] Cell. 1998 Nov 13;95(4):541-52 [9827806] J Biol Chem. 1999 Mar 5;274(10):6336-41 [10037723] Protein Sci. 1998 Aug;7(8):1781-8 [10082375] Cell. 1999 Apr 2;97(1):85-97 [10199405] Anal Chem. 1999 Sep 15;71(18):3965-73 [10500483] Biochemistry. 2005 Mar 8;44(9):3166-75 [15736927] Anal Biochem. 2005 May 15;340(2):201-12 [15840492] Anal Biochem. 2005 Jun 1;341(1):122-30 [15866536] Annu Rev Biochem. 2005;74:681-710 [15952900] Anal Chem. 2005 Jul 15;77(14):4549-55 [16013872] Chem Rev. 2007 Aug;107(8):3514-43 [17683160] J Biol Chem. 2007 Dec 21;282(51):37181-90 [17951253] Bioconjug Chem. 2000 May-Jun;11(3):335-44 [10821649] Nucleic Acids Res. 2001 Apr 15;29(8):1695-702 [11292842] EMBO J. 2001 Oct 1;20(19):5521-31 [11574484] J Mol Biol. 2001 Sep 28;312(4):637-47 [11575920] J Biol Chem. 2002 Feb 1;277(5):3673-9 [11717305] Protein Sci. 2008 Jan;17(1):79-94 [18042684] Structure. 2008 Jan;16(1):38-51 [18184582] Mol Cell. 2008 Jan 18;29(1):112-21 [18206974] Curr Protein Pept Sci. 2008 Feb;9(1):1-15 [18336319] Anal Chem. 2008 Mar 15;80(6):2222-31 [18260674] J Am Soc Mass Spectrom. 2008 Nov;19(11):1692-705 [18707901] Biochemistry. 2009 Jun 2;48(21):4577-86 [19354299] Mol Cell Proteomics. 2009 Aug;8(8):1999-2010 [19473960] Hum Mutat. 2005 Aug;26(2):63-8 [15977173] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.dnarep.2011.01.010 ER - TY - JOUR T1 - Lateral density of receptor arrays in the membrane plane influences sensitivity of the E. coli chemotaxis response AN - 1323820748; 16451470 AB - In chemotactic bacteria, transmembrane chemoreceptors, CheA and CheW form the core signalling complex of the chemotaxis sensory apparatus. These complexes are organized in extended arrays in the cytoplasmic membrane that allow bacteria to respond to changes in concentration of extracellular ligands via a cooperative, allosteric response that leads to substantial amplification of the signal induced by ligand binding. Here, we have combined cryo-electron tomographic studies of the 3D spatial architecture of chemoreceptor arrays in intact E. coli cells with computational modelling to develop a predictive model for the cooperativity and sensitivity of the chemotaxis response. The predictions were tested experimentally using fluorescence resonance energy transfer (FRET) microscopy. Our results demonstrate that changes in lateral packing densities of the partially ordered, spatially extended chemoreceptor arrays can modulate the bacterial chemotaxis response, and that information about the molecular organization of the arrays derived by cryo-electron tomography of intact cells can be translated into testable, predictive computational models of the chemotaxis response. JF - EMBO Journal AU - Khursigara, Cezar M AU - Lan, Ganhui AU - Neumann, Silke AU - Wu, Xiongwu AU - Ravindran, Suchie AU - Borgnia, Mario J AU - Sourjik, Victor AU - Milne, Jacqueline AU - Tu, Yuhai AU - Subramaniam, Sriram AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Y1 - 2011/05/04/ PY - 2011 DA - 2011 May 04 SP - 1719 EP - 1729 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 30 IS - 9 SN - 0261-4189, 0261-4189 KW - Microbiology Abstracts B: Bacteriology; Chemoreception Abstracts KW - Chemoreceptors KW - Mathematical models KW - CheW protein KW - fluorescence resonance energy transfer KW - Packing KW - Computer applications KW - CheA protein KW - Chemotaxis KW - Allosteric properties KW - Microscopy KW - Escherichia coli KW - Cytoplasmic membranes KW - Receptor density KW - Tomography KW - Cooperativity KW - R 18003:Chemotaxis KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1323820748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EMBO+Journal&rft.atitle=Lateral+density+of+receptor+arrays+in+the+membrane+plane+influences+sensitivity+of+the+E.+coli+chemotaxis+response&rft.au=Khursigara%2C+Cezar+M%3BLan%2C+Ganhui%3BNeumann%2C+Silke%3BWu%2C+Xiongwu%3BRavindran%2C+Suchie%3BBorgnia%2C+Mario+J%3BSourjik%2C+Victor%3BMilne%2C+Jacqueline%3BTu%2C+Yuhai%3BSubramaniam%2C+Sriram&rft.aulast=Khursigara&rft.aufirst=Cezar&rft.date=2011-05-04&rft.volume=30&rft.issue=9&rft.spage=1719&rft.isbn=&rft.btitle=&rft.title=EMBO+Journal&rft.issn=02614189&rft_id=info:doi/10.1038%2Femboj.2011.77 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-04-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Chemoreceptors; CheW protein; Mathematical models; fluorescence resonance energy transfer; Packing; Computer applications; Chemotaxis; CheA protein; Allosteric properties; Microscopy; Receptor density; Cytoplasmic membranes; Tomography; Cooperativity; Escherichia coli DO - http://dx.doi.org/10.1038/emboj.2011.77 ER - TY - JOUR T1 - Evidence for erythrocyte-binding antigen 175 as a component of a ligand-blocking blood-stage malaria vaccine AN - 907152792; 14812231 AB - The ligands that pathogens use to invade their target cells have often proven to be good targets for vaccine development. However, Plasmodium falciparum has redundant ligands that mediate invasion of erythrocytes. The first requirement for the development of a successful ligand-blocking malaria vaccine is the demonstration that antibodies induced to each ligand can block the erythrocyte invasion of parasites with polymorphic sequences. Because of P. falciparum's redundancy in erythrocyte invasion, each ligand needs to be studied under artificial conditions in which parasite invasion is restricted in its use of alternative pathways. Here we investigate the role of erythrocyte-binding antigen 175 (EBA-175), a parasite ligand that binds to sialic acid on glycophorin A, in the invasion of erythrocytes by 10 P. falciparum clones under conditions in which invasion is partially limited to the EBA-175-glycophorin A pathway, using chymotrypsin-treated erythrocytes. We show that the ability to invade erythrocytes for both sialic acid-independent and sialic acid-dependent pathways requires the EBA-175-glycophorin A pathway for erythrocyte invasion. Importantly, antibodies against region II of EBA-175 from the 3D7 clone blocked invasion of chymotrypsin-treated erythrocytes by >50% by all parasite clones studied, including those with multiple different mutations described in the literature. The one exception was FCR3, which had a similar sequence to 3D7 but only 30% inhibition of invasion of chymotrypsin-treated erythrocytes, indicating alternative pathways for invasion of chymotrypsin-treated erythrocytes. Our findings suggest that antibodies to region II of EBA-175, as one component of a ligand-blocking malaria vaccine, are largely unaffected by polymorphism in EBA-175. JF - Proceedings of the National Academy of Sciences, USA AU - Jiang, Lubin AU - Gaur, Deepak AU - Mu, Jianbing AU - Zhou, Hong AU - Long, Carole A AU - Miller, Louis H AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 and Malaria Group, International Center for Genetic Engineering and Biotechnology, New Delhi 110067, India Y1 - 2011/05/03/ PY - 2011 DA - 2011 May 03 SP - 7553 EP - 7558 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 108 IS - 18 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Clones KW - Parasites KW - Human diseases KW - Erythrocytes KW - Disease control KW - Malaria KW - Plasmodium falciparum KW - Pathogens KW - Public health KW - Antibodies KW - Vaccines KW - Mutation KW - Sialic acids KW - Ligands KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907152792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Evidence+for+erythrocyte-binding+antigen+175+as+a+component+of+a+ligand-blocking+blood-stage+malaria+vaccine&rft.au=Jiang%2C+Lubin%3BGaur%2C+Deepak%3BMu%2C+Jianbing%3BZhou%2C+Hong%3BLong%2C+Carole+A%3BMiller%2C+Louis+H&rft.aulast=Jiang&rft.aufirst=Lubin&rft.date=2011-05-03&rft.volume=108&rft.issue=18&rft.spage=7553&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Clones; Parasites; Human diseases; Antibodies; Erythrocytes; Disease control; Vaccines; Ligands; Public health; Malaria; Pathogens; Mutation; Sialic acids; Plasmodium falciparum ER - TY - JOUR T1 - Synergistic enhancement of human bone marrow stromal cell proliferation and osteogenic differentiation on BMP-2-derived and RGD peptide concentration gradients AN - 918070268; 16182419 AB - Rational design of bioactive tissue engineered scaffolds for directing bone regeneration in vivo requires a comprehensive understanding of cell interactions with the immobilized bioactive molecules. In the current study, substrates possessing gradient concentrations of immobilized peptides were used to measure the concentration-dependent proliferation and osteogenic differentiation of human bone marrow stromal cells. Two bioactive peptides, one derived from extracellular matrix protein (ECM), GRGDS, and one from bone morphogenic protein-2 (BMP-2), KIPKASSVPTELSAISTLYL, were found to synergistically enhance cell proliferation, up-regulate osteogenic mRNA markers bone sialoprotein (BSP) and Runt-related transcription factor 2, and produce mineralization at densities greater than 130 pmol cm-2 (65 pmol cm-2 for each peptide). In addition, COOH-terminated self-assembled monolayers alone led to up-regulated BSP mRNA levels at densities above 200 pmol cm-2 and increased cell proliferation from day 3 to day 14. Taking further advantage of both the synergistic potentials and the concentration-dependent activities of ECM and growth-factor-derived peptides on proliferative activity and osteogenic differentiation, without the need for additional osteogenic supplements, will enable the successful incorporation of the bioactive species into biorelevant tissue engineering scaffolds. JF - Acta Biomaterialia AU - Moore, Nicole M AU - Lin, Nancy J AU - Gallant, Nathan D AU - Becker, Matthew L AD - Polymers Division, National Institute of Standards and Technology, Gaithersburg, MD 20899-8543, USA, nicole.moore@nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 2091 EP - 2100 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 7 IS - 5 SN - 1742-7061, 1742-7061 KW - Biotechnology and Bioengineering Abstracts KW - Bioactive gradients KW - BMP-2 KW - RGD KW - Cell proliferation KW - Click chemistry KW - stromal cells KW - Bone growth KW - Bone marrow KW - Mineralization KW - Tissue engineering KW - scaffolds KW - Differentiation KW - Bone sialoprotein KW - Transcription factors KW - Extracellular matrix KW - Regeneration KW - Bone morphogenetic protein 2 KW - Cell interactions KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918070268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Biomaterialia&rft.atitle=Synergistic+enhancement+of+human+bone+marrow+stromal+cell+proliferation+and+osteogenic+differentiation+on+BMP-2-derived+and+RGD+peptide+concentration+gradients&rft.au=Moore%2C+Nicole+M%3BLin%2C+Nancy+J%3BGallant%2C+Nathan+D%3BBecker%2C+Matthew+L&rft.aulast=Moore&rft.aufirst=Nicole&rft.date=2011-05-01&rft.volume=7&rft.issue=5&rft.spage=2091&rft.isbn=&rft.btitle=&rft.title=Acta+Biomaterialia&rft.issn=17427061&rft_id=info:doi/10.1016%2Fj.actbio.2011.01.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - stromal cells; Bone marrow; Bone growth; Tissue engineering; Mineralization; scaffolds; Differentiation; Bone sialoprotein; Extracellular matrix; Transcription factors; Regeneration; Cell interactions; Bone morphogenetic protein 2; Cell proliferation DO - http://dx.doi.org/10.1016/j.actbio.2011.01.019 ER - TY - JOUR T1 - Using cross-validation to evaluate predictive accuracy of survival risk classifiers based on high-dimensional data AN - 915487412; 16101623 AB - Developments in whole genome biotechnology have stimulated statistical focus on prediction methods. We review here methodology for classifying patients into survival risk groups and for using cross-validation to evaluate such classifications. Measures of discrimination for survival risk models include separation of survival curves, time-dependent ROC curves and Harrell's concordance index. For high-dimensional data applications, however, computing these measures as re-substitution statistics on the same data used for model development results in highly biased estimates. Most developments in methodology for survival risk modeling with high-dimensional data have utilized separate test data sets for model evaluation. Cross-validation has sometimes been used for optimization of tuning parameters. In many applications, however, the data available are too limited for effective division into training and test sets and consequently authors have often either reported re-substitution statistics or analyzed their data using binary classification methods in order to utilize familiar cross-validation. In this article we have tried to indicate how to utilize cross-validation for the evaluation of survival risk models; specifically how to compute cross-validated estimates of survival distributions for predicted risk groups and how to compute cross-validated time-dependent ROC curves. We have also discussed evaluation of the statistical significance of a survival risk model and evaluation of whether high-dimensional genomic data adds predictive accuracy to a model based on standard covariates alone. JF - Briefings in Bioinformatics AU - Simon, Richard M AU - Subramanian, Jyothi AU - Li, Ming-Chung AU - Menezes, Supriya Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 203 EP - 214 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 12 IS - 3 SN - 1467-5463, 1467-5463 KW - Biotechnology and Bioengineering Abstracts KW - predictive medicine KW - survival risk classification KW - cross-validation KW - gene expression KW - Genomes KW - Data processing KW - Statistics KW - Risk factors KW - Statistical analysis KW - Survival KW - Risk groups KW - Bioinformatics KW - genomics KW - Development KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/915487412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Briefings+in+Bioinformatics&rft.atitle=Using+cross-validation+to+evaluate+predictive+accuracy+of+survival+risk+classifiers+based+on+high-dimensional+data&rft.au=Simon%2C+Richard+M%3BSubramanian%2C+Jyothi%3BLi%2C+Ming-Chung%3BMenezes%2C+Supriya&rft.aulast=Simon&rft.aufirst=Richard&rft.date=2011-05-01&rft.volume=12&rft.issue=3&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Briefings+in+Bioinformatics&rft.issn=14675463&rft_id=info:doi/10.1093%2Fbib%2Fbbr001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Genomes; Statistics; Data processing; Risk factors; Statistical analysis; Risk groups; Survival; Development; genomics; Bioinformatics; Models DO - http://dx.doi.org/10.1093/bib/bbr001 ER - TY - JOUR T1 - Intercultural communicative competence: exploring English language teachers' beliefs and practices AN - 908018835; 201112959 AB - This paper reports on an investigation into the beliefs and practices of experienced teachers in the USA, UK and France relating to the application of a model of intercultural communicative competence (ICC) to English language programmes. Broadly, 'intercultural' approaches to language learning and teaching are strongly advocated in both the recent theoretical applied linguistics literature and in curricular guidance in frameworks such as the Council of Europe's Common European framework of reference for languages. However, little prior empirical research has addressed the extent to which such approaches are actually operationalised. The investigation was multimethodological, combining diaries, focus groups, and questionnaires. Byram's language-pedagogical model of ICC was the specific focus. Findings indicated a general consensus across locations, with an apparent disparity between teachers' attitudes to and beliefs about ICC and their current classroom priorities. Most reported beliefs that supported the relevance of interculturality to their work and stressed that 'good' learners and teachers tended to exhibit high intercultural competence. However, they also suggested that ICC was given relatively little emphasis in syllabi which were negotiated with learners. Participants also identified and discussed a lack of support, in testing, in textbooks, and in institutional syllabi, for effective and appropriate approaches to 'culture learning' and interculturality. Adapted from the source document JF - Language Awareness AU - Young, Tony Johnstone AU - Sachdev, Itesh AD - School of Education, Communication & Language Sciences, Newcastle University, Newcastle Upon Tyne, NEI 7RU, UK tony.young@ncl.ac.uk Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 81 EP - 98 VL - 20 IS - 2 SN - 0965-8416, 0965-8416 KW - Cross Cultural Communication (16300) KW - France (25500) KW - United Kingdom (92700) KW - Second Language Teachers (76120) KW - English as a Second Language Instruction (22120) KW - United States of America (92750) KW - Teacher Attitudes (87840) KW - Communicative Competence (13650) KW - article KW - 4130: applied linguistics; English as a second/foreign language instruction KW - 5516: interpersonal behavior and communication; cross-cultural communication and behavior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/908018835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Language+Awareness&rft.atitle=Intercultural+communicative+competence%3A+exploring+English+language+teachers%27+beliefs+and+practices&rft.au=Young%2C+Tony+Johnstone%3BSachdev%2C+Itesh&rft.aulast=Young&rft.aufirst=Tony&rft.date=2011-05-01&rft.volume=20&rft.issue=2&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Language+Awareness&rft.issn=09658416&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2011-12-01 N1 - Last updated - 2016-09-27 N1 - CODEN - LAAWEN N1 - SubjectsTermNotLitGenreText - Cross Cultural Communication (16300); Communicative Competence (13650); Second Language Teachers (76120); English as a Second Language Instruction (22120); Teacher Attitudes (87840); United States of America (92750); United Kingdom (92700); France (25500) ER - TY - JOUR T1 - Listeriosis in human pregnancy: a systematic review AN - 907160332; 14941411 AB - Listeria is commonly found in processed and prepared foods and listeriosis is associated with high morbidity and mortality. Preventative measures are well prescribed and monitoring and voluntary recall of contaminated products has resulted in a 44% reduction in the prevalence of perinatal listeriosis in the USA. Pregnant women are at high risk for listeriosis, but symptoms are non-specific and diagnosis is difficult. The intracellular life-cycle of Listeria protects the bacterium from host innate and adaptive immune responses. Antibiotic treatment requires agents able to penetrate, distribute, and remain stable within host cells. Prolonged use of high-dose ampicillin can significantly improve neonatal outcome. JF - Journal of Perinatal Medicine AU - Lamont, Ronald F AU - Sobel, Jack AU - Mazaki-Tovi, Shali AU - Kusanovic, Juan Pedro AU - Vaisbuch, Edi AU - Kim, Sun Kwon AU - Uldbjerg, Niels AU - Romero, Roberto AD - Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland and Detroit, MI, USA Y1 - 2011/05/01/ PY - 2011 DA - 2011 May 01 SP - 227 EP - 236 PB - Walter de Gruyter und Co., Genthiner Str. 13 Berlin 10785 Germany VL - 39 IS - 3 SN - 0300-5577, 0300-5577 KW - Microbiology Abstracts B: Bacteriology KW - Food processing KW - Mortality KW - Listeriosis KW - Ampicillin KW - Antibiotics KW - Listeria KW - Morbidity KW - Pregnancy KW - Reviews KW - Risk factors KW - Neonates KW - Immune response KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907160332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Perinatal+Medicine&rft.atitle=Listeriosis+in+human+pregnancy%3A+a+systematic+review&rft.au=Lamont%2C+Ronald+F%3BSobel%2C+Jack%3BMazaki-Tovi%2C+Shali%3BKusanovic%2C+Juan+Pedro%3BVaisbuch%2C+Edi%3BKim%2C+Sun+Kwon%3BUldbjerg%2C+Niels%3BRomero%2C+Roberto&rft.aulast=Lamont&rft.aufirst=Ronald&rft.date=2011-05-01&rft.volume=39&rft.issue=3&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Journal+of+Perinatal+Medicine&rft.issn=03005577&rft_id=info:doi/10.1515%2FJPM.2011.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Food processing; Mortality; Listeriosis; Risk factors; Reviews; Ampicillin; Antibiotics; Immune response; Neonates; Morbidity; Pregnancy; Listeria DO - http://dx.doi.org/10.1515/JPM.2011.035 ER - TY - JOUR T1 - Nucleotide Excision Repair Proteins Rapidly Accumulate but Fail to Persist in Human XPaE (DDB2 Mutant) Cells AN - 902355813; 14717267 AB - The xeroderma pigmentosum (XP-E) DNA damage binding protein (DDB2) is involved in early recognition of global genome DNA damage during DNA nucleotide excision repair (NER). We found that skin fibroblasts from four newly reported XP-E patients with numerous skin cancers and DDB2 mutations had slow repair of 6-4 photoproducts (6-4PP) and markedly reduced repair of cyclobutane pyrimidine dimers (CPD). NER proteins (XPC, XPB, XPG, XPA and XPF) colocalized to CPD and 6-4PP positive regions immediately (<0.1h) after localized UV irradiation in cells from the XP-E patients and normal controls. While these proteins persist in normal cells, surprisingly, within 0.5h these repair proteins were no longer detectable at the sites of DNA damage in XP-E cells. Our results indicate that DDB2 is not required for the rapid recruitment of NER proteins to sites of UV photoproducts or for partial repair of 6-4PP but is essential for normal persistence of these proteins for CPD photoproduct removal. JF - Photochemistry and Photobiology AU - Oh, KyuaSeon AU - Imoto, Kyoko AU - Emmert, Steffen AU - Tamura, Deborah AU - DiGiovanna, John J AU - Kraemer, Kenneth H AD - DNA Repair Section, Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD PY - 2011 SP - 729 EP - 733 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 87 IS - 3 SN - 0031-8655, 0031-8655 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - DNA damage KW - XPC protein KW - U.V. radiation KW - Nucleotide excision repair KW - Cyclobutane pyrimidine dimers KW - Skin cancer KW - DNA repair KW - Xeroderma pigmentosum KW - Mutation KW - Fibroblasts KW - X 24310:Pharmaceuticals KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902355813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+Photobiology&rft.atitle=Nucleotide+Excision+Repair+Proteins+Rapidly+Accumulate+but+Fail+to+Persist+in+Human+XPaE+%28DDB2+Mutant%29+Cells&rft.au=Oh%2C+KyuaSeon%3BImoto%2C+Kyoko%3BEmmert%2C+Steffen%3BTamura%2C+Deborah%3BDiGiovanna%2C+John+J%3BKraemer%2C+Kenneth+H&rft.aulast=Oh&rft.aufirst=KyuaSeon&rft.date=2011-05-01&rft.volume=87&rft.issue=3&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+Photobiology&rft.issn=00318655&rft_id=info:doi/10.1111%2Fj.1751-1097.2011.00909.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Document feature - figure 3 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Genomes; DNA damage; XPC protein; U.V. radiation; Nucleotide excision repair; Cyclobutane pyrimidine dimers; Skin cancer; Xeroderma pigmentosum; DNA repair; Mutation; Fibroblasts DO - http://dx.doi.org/10.1111/j.1751-1097.2011.00909.x ER - TY - JOUR T1 - Identification of Mycobacteria in Solid-Culture Media by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry AN - 899162722; 15404084 AB - Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has recently been introduced into the clinical microbiology laboratory as a rapid and accurate method to identify bacteria and yeasts. In this paper we describe our work on the use of MALDI-TOF MS for the identification of mycobacterial isolates. We developed a protocol for protein extraction from mycobacteria and utilized it to construct a database containing 42 clinically relevant type and reference strains of mycobacteria. The database was used to identify 104 clinical isolates of mycobacteria. All members of the Mycobacterium tuberculosis complex were identified accurately at the complex level but could not be separated at the species level. All other organisms were identified at the species level, with the exception of one strain of M. kansasii (accurately identified but with a low spectral score) and three pairs of closely related strains: M. abscessus and M. massiliense, M. mucogenicum and M. phocaicum, and M. chimaera and M. intracellulare. These pairs of organisms can currently be identified only by multilocus gene sequence analysis. We conclude that MALDI-TOF MS analysis can be incorporated into the work flow of the microbiology laboratory for rapid and accurate identification of most strains of mycobacteria isolated from solid growth media. JF - Journal of Clinical Microbiology AU - Saleeb, Paul G AU - Drake, Steven K AU - Murray, Patrick R AU - Zelazny, Adrian M AD - Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, azelazny@mail.nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 1790 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 49 IS - 5 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Databases KW - Lasers KW - Mass spectroscopy KW - Mycobacterium tuberculosis KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899162722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Identification+of+Mycobacteria+in+Solid-Culture+Media+by+Matrix-Assisted+Laser+Desorption+Ionization-Time+of+Flight+Mass+Spectrometry&rft.au=Saleeb%2C+Paul+G%3BDrake%2C+Steven+K%3BMurray%2C+Patrick+R%3BZelazny%2C+Adrian+M&rft.aulast=Saleeb&rft.aufirst=Paul&rft.date=2011-05-01&rft.volume=49&rft.issue=5&rft.spage=1790&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.02135-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Number of references - 23 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Databases; Lasers; Mass spectroscopy; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1128/JCM.02135-10 ER - TY - JOUR T1 - Eating patterns and nutritional characteristics associated with sleep duration AN - 899161303; 15748212 AB - To identify major meal and snack eating patterns, and examine their relationships with sleep duration. The analyses included 27 983 participants in a prospective cohort study of women aged 35 to 74 years in the USA or Puerto Rico. The principal component analysis of eight meal and snack frequency items at different times across the day yielded two major eating patterns: (i) eating during conventional eating hours (defined as times from breakfast to dinner); and (ii) dominance of snacks over meals. Comparing the identified eating patterns among women with varying sleep duration (<5, 5-5.9, 6-6.9, 7-7.9, 8-8.9, 9-9.9 and greater than or equal to 10 h daily), the tendency for eating during conventional eating hours decreased with decreasing sleep duration: adjusted mean score of -0.54 (95 % CI -0.68, -0.41) in women sleeping for <5 h daily v. 0.08 (95 % CI 0.06, 0.11) among those with 7-7.9 h of sleep daily. The extent of snack dominance over meals increased in women with shorter sleep. Women with long ( greater than or equal to 10 h) sleep duration had eating patterns similar to those with short (<6 h) sleep duration. Lower tendency for eating during conventional eating hours and greater snack dominance over meals were also related to higher intakes of fat and sweets for energy and lower intakes of fruits and vegetables. Disrupted eating patterns and diet of poor nutritional quality may exacerbate the development of obesity and metabolic diseases in habitual short and very long sleepers. JF - Public Health Nutrition AU - Kim, Sangmi AU - DeRoo, Lisa A AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233 - MD A3-05, 111 T.W. Alexander Drive, Research Triangle Park, NC 27599, USA, sandler@niehs.nih.gov sandler@niehs.nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 889 EP - 895 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 14 IS - 5 SN - 1368-9800, 1368-9800 KW - Health & Safety Science Abstracts KW - Diets KW - ASW, Caribbean Sea, Greater Antilles, Puerto Rico KW - Sleep KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899161303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Nutrition&rft.atitle=Eating+patterns+and+nutritional+characteristics+associated+with+sleep+duration&rft.au=Kim%2C+Sangmi%3BDeRoo%2C+Lisa+A%3BSandler%2C+Dale+P&rft.aulast=Kim&rft.aufirst=Sangmi&rft.date=2011-05-01&rft.volume=14&rft.issue=5&rft.spage=889&rft.isbn=&rft.btitle=&rft.title=Public+Health+Nutrition&rft.issn=13689800&rft_id=info:doi/10.1017%2FS136898001000296X LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Sleep; ASW, Caribbean Sea, Greater Antilles, Puerto Rico DO - http://dx.doi.org/10.1017/S136898001000296X ER - TY - JOUR T1 - ROC curve inference for best linear combination of two biomarkers subject to limits of detection AN - 888096393; 15039093 AB - The receiver operating characteristic (ROC) curve is a tool commonly used to evaluate biomarker utility in clinical diagnosis of disease. Often, multiple biomarkers are developed to evaluate the discrimination for the same outcome. Levels of multiple biomarkers can be combined via best linear combination (BLC) such that their overall discriminatory ability is greater than any of them individually. Biomarker measurements frequently have undetectable levels below a detection limit sometimes denoted as limit of detection (LOD). Ignoring observations below the LOD or substituting some replacement value as a method of correction has been shown to lead to negatively biased estimates of the area under the ROC curve for some distributions of single biomarkers. In this paper, we develop asymptotically unbiased estimators, via the maximum likelihood technique, of the area under the ROC curve of BLC of two bivariate normally distributed biomarkers affected by LODs. We also propose confidence intervals for this area under curve. Point and confidence interval estimates are scrutinized by simulation study, recording bias and root mean square error and coverage probability, respectively. An example using polychlorinated biphenyl (PCB) levels to classify women with and without endometriosis illustrates the potential benefits of our methods. JF - Biometrical Journal AU - Perkins, Neil J AU - Schisterman, Enrique F AU - Vexler, Albert AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd, rm 7b03, Rockville, MD 20852, USA, perkinson@mail.nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 464 EP - 476 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 53 IS - 3 SN - 1521-4036, 1521-4036 KW - Biotechnology and Bioengineering Abstracts KW - polychlorinated biphenyls KW - Statistics KW - Endometriosis KW - Biometrics KW - biomarkers KW - PCB KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888096393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=ROC+curve+inference+for+best+linear+combination+of+two+biomarkers+subject+to+limits+of+detection&rft.au=Perkins%2C+Neil+J%3BSchisterman%2C+Enrique+F%3BVexler%2C+Albert&rft.aulast=Perkins&rft.aufirst=Neil&rft.date=2011-05-01&rft.volume=53&rft.issue=3&rft.spage=464&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=15214036&rft_id=info:doi/10.1002%2Fbimj.201000083 L2 - http://onlinelibrary.wiley.com/doi/10.1002/bimj.201000083/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Statistics; polychlorinated biphenyls; Endometriosis; Biometrics; biomarkers; PCB DO - http://dx.doi.org/10.1002/bimj.201000083 ER - TY - JOUR T1 - The Office of Health Assessment and Translation: A Problem-Solving Resource for the National Toxicology Program AN - 885054323; 15090561 JF - Environmental Health Perspectives AU - Bucher, John R AU - Thayer, Kristina AU - Birnbaum, Linda S AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, bucher@niehs.nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - A196 EP - A197 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 119 IS - 5 SN - 0091-6765, 0091-6765 KW - Pollution Abstracts; Environment Abstracts KW - Toxicology KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885054323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Office+of+Health+Assessment+and+Translation%3A+A+Problem-Solving+Resource+for+the+National+Toxicology+Program&rft.au=Bucher%2C+John+R%3BThayer%2C+Kristina%3BBirnbaum%2C+Linda+S&rft.aulast=Bucher&rft.aufirst=John&rft.date=2011-05-01&rft.volume=119&rft.issue=5&rft.spage=A196&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1103645 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Toxicology DO - http://dx.doi.org/10.1289/ehp.1103645 ER - TY - JOUR T1 - T1 mapping of the gadolinium-enhanced myocardium: Adjustment for factors affecting interpatient comparison AN - 883029564; 15255861 AB - Quantitative T1 mapping of delayed gadolinium-enhanced cardiac magnetic resonance imaging has shown promise in identifying diffuse myocardial fibrosis. Despite careful control of magnetic resonance imaging parameters, comparison of T1 times between different patients may be problematic because of patient specific factors such as gadolinium dose, differing glomerular filtration rates, and patient specific delay times. In this work, a model driven approach to account for variations between patients to allow for comparison of T1 data is provided. Kinetic model parameter values were derived from healthy volunteer time-contrast curves. Correction values for the factors described above were used to normalize T1 values to a matched state. Examples of pre- and postcorrected values for a pool of normal subjects and in a patient cohort of type 1 diabetic patients shows tighter clustering and improved discrimination of disease state. Magn Reson Med, 2011. [copy 2010 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Gai, Neville AU - Turkbey, Evrim B AU - Nazarian, Saman AU - van der Geest, Rob J AU - Liu, Chia-Ying AU - Lima, Joao A C AU - Bluemke, David A AD - Radiology and Imaging Sciences, Clinical Center, and National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, USA, gaind@cc.nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 1407 EP - 1415 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 65 IS - 5 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Data processing KW - Fibrosis KW - Magnetic resonance imaging KW - Gadolinium KW - Glomerular filtration rate KW - Models KW - Diabetes mellitus KW - Kinetics KW - N.M.R. KW - Mapping KW - Myocardium KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883029564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=T1+mapping+of+the+gadolinium-enhanced+myocardium%3A+Adjustment+for+factors+affecting+interpatient+comparison&rft.au=Gai%2C+Neville%3BTurkbey%2C+Evrim+B%3BNazarian%2C+Saman%3Bvan+der+Geest%2C+Rob+J%3BLiu%2C+Chia-Ying%3BLima%2C+Joao+A+C%3BBluemke%2C+David+A&rft.aulast=Gai&rft.aufirst=Neville&rft.date=2011-05-01&rft.volume=65&rft.issue=5&rft.spage=1407&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22716 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22716/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Heart; Diabetes mellitus; Data processing; Fibrosis; Kinetics; Gadolinium; Magnetic resonance imaging; N.M.R.; Mapping; Glomerular filtration rate; Myocardium; Models DO - http://dx.doi.org/10.1002/mrm.22716 ER - TY - JOUR T1 - Population-Based Ectopic Pregnancy Trends, 1993-2007 AN - 881449556; 201115234 AB - The accuracy of ectopic pregnancy rates based on nationally representative data has been compromised for many years, impairing surveillance and evaluation of the continued public health importance of this condition To estimate long-term population-based ectopic pregnancy rates and trends within a defined population over a largely unevaluated time period, including the evaluation of trends in outpatient versus inpatient management and medical versus surgical treatment modalities. Methods: Using computerized Group Health Cooperative inpatient and outpatient data, age-adjusted and age-specific ectopic pregnancy rates were calculated from 1993 to 2007 among enrollees aged 15-44 years. Overall trends and trends for care setting (inpatient versus outpatient) and treatment modality (medical versus surgical) were also evaluated. Analyses were conducted in 2009. Results: Between 1993 and 2007, a total of 2114 ectopic pregnancy cases (726 inpatient; 1388 outpatient) were identified among 1,180,070 woman-years, an annual age-adjusted ectopic pregnancy rate of 17.9 per 10,000 woman-years. Rates were stable from 1993 to 2004 and increased in the most recent 3 years (2005-2007, rate=21.1 per 10,000 woman-years). Rates per 1000 pregnancies increased over the 15-year period from 19.2 to 26.2 per 1000 pregnancies (p-value=0.001). Inpatient-diagnosed cases decreased from 45.4% in 1993-1995 to 26.9% in 2005-2007 (p-value<0.0001) and the percentage with surgical treatment decreased from 48.1% to 30.7% (p-value<0.0001). Conclusions: The results suggest a trend toward increasing ectopic pregnancy rates over a recent 15-year period. Rates are similar to the last available national estimate, suggesting that the significance of ectopic pregnancy as a public health problem has not diminished in these intervening years. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Trabert, Britton AU - Holt, Victoria L AU - Yu, Onchee AU - Van den Eeden, Stephen K. AU - Scholes, Delia AD - Department of Epidemiology, University of Washington, Seattle, Washington trabertbl@mail.nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 556 EP - 560 PB - Elsevier Science, New York NY VL - 40 IS - 5 SN - 0749-3797, 0749-3797 KW - Hospitalization KW - Ectopic pregnancy KW - Surveillance KW - Pregnancy KW - Public health KW - Outpatient treatment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881449556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Population-Based+Ectopic+Pregnancy+Trends%2C+1993-2007&rft.au=Trabert%2C+Britton%3BHolt%2C+Victoria+L%3BYu%2C+Onchee%3BVan+den+Eeden%2C+Stephen+K.%3BScholes%2C+Delia&rft.aulast=Trabert&rft.aufirst=Britton&rft.date=2011-05-01&rft.volume=40&rft.issue=5&rft.spage=556&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2010.12.026 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-08-04 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Ectopic pregnancy; Hospitalization; Outpatient treatment; Public health; Pregnancy; Surveillance DO - http://dx.doi.org/10.1016/j.amepre.2010.12.026 ER - TY - JOUR T1 - The "Gray Area" of Consumption Between Moderate and Risk Drinking AN - 881449151; 201113973 AB - Objective: The objective of this study was to see whether levels of alcohol consumption newly included as "moderate" in proposed changes to the 2010 Dietary Guidelines for Americans are associated with significant levels of alcohol-related harm. Method: Using longitudinal data from a nationally representative sample of U.S. adults (N = 26,438; 51.8% female), we compared relative risks and population attributable fractions for nine measures of concurrent and eight measures of prospective alcohol-related harm among three groups of drinkers: those whose consumption lay within the old 2005 Dietary Guidelines for Americans guidelines for moderate drinking, those in the "gray area" of consumption between the 2005 and proposed 2010 Dietary Guidelines for Americans, and those who exceeded the proposed 2010 Dietary Guidelines for Americans. Results: The gray area of consumption was associated with small but significantly increased risks of prevalent and incident alcohol dependence, incident alcohol-related interpersonal problems, and prevalent job loss. There were no associations with medical conditions or mental disorders. Although the harms associated with this level of consumption reflected low absolute and/or relative risks of harm, their impact was not negligible because of the large proportion of drinkers in the gray area of consumption (29.1%). The overwhelming majority of incident harm among baseline gray area drinkers was associated with consumption that had increased over the follow-up interval to exceed the proposed 2010 Dietary Guidelines for Americans. Conclusions: We recommend two alternative approaches to rewording the proposed changes to the 2010 Dietary Guidelines for Americans that would avoid suggesting that there are benefits associated with the gray area of alcohol consumption. Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - Dawson, Deborah A AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, National Institute on Alcohol Abuse and Alcoholism, 5635 Fishers Lane MSC 9304, Room 3093, National Institutes of Health, Bethesda, Maryland 20892-9304 ddawson@mail.nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 453 EP - 458 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 72 IS - 3 SN - 1937-1888, 1937-1888 KW - Alcohol consumption KW - American people KW - Psychiatric disorders KW - Consumption KW - Relative risks KW - Alcohol related KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881449151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=The+%22Gray+Area%22+of+Consumption+Between+Moderate+and+Risk+Drinking&rft.au=Dawson%2C+Deborah+A%3BGrant%2C+Bridget+F&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2011-05-01&rft.volume=72&rft.issue=3&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-08-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Consumption; American people; Alcohol consumption; Relative risks; Alcohol related; Psychiatric disorders ER - TY - JOUR T1 - Ethnic Pride and Cardiovascular Health Among Mexican American Adults Along the U.S.-Mexico Border AN - 876244885; 14876153 AB - This study addressed the association between items from the General Acculturation Index (GAI) and cardiovascular health. Specifically, we assessed whether ethnic pride was associated with health outcomes after controlling for items regarding language, place where the childhood was spent, and ethnic interaction. The study was a cross-sectional analysis of demographic and clinical data from a border population of Mexican American adults (n = 316) at risk for cardiovascular disease (CVD). Outcomes included smoking and diabetes status, Framingham risk, and metabolic syndrome. Ethnic pride was associated with lower diabetes prevalence, lower Framingham risk, and fewer risk factors for metabolic syndrome but was not associated with smoking status. Ethnic pride was not associated with the other acculturation items of the GAI. Among an at-risk border population, ethnic pride functioned independently of other acculturation indicators. Ethnic pride may act as a protective factor for diabetes, metabolic syndrome, and CVD risk status. JF - Hispanic Journal of Behavioral Sciences AU - de Heer, Hendrik Dirk AU - Balcazar, Hector G AU - Lee Rosenthal, E AU - Cardenas, Victor M AU - Schulz, Leslie O AD - University of Texas at El Paso, Department of Psychology, El Paso,Texas, dirk.deheer@nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 204 EP - 220 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 33 IS - 2 SN - 0739-9863, 0739-9863 KW - Risk Abstracts KW - demography KW - Smoking KW - metabolic disorders KW - diabetes mellitus KW - Cardiovascular diseases KW - Children KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876244885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hispanic+Journal+of+Behavioral+Sciences&rft.atitle=Ethnic+Pride+and+Cardiovascular+Health+Among+Mexican+American+Adults+Along+the+U.S.-Mexico+Border&rft.au=de+Heer%2C+Hendrik+Dirk%3BBalcazar%2C+Hector+G%3BLee+Rosenthal%2C+E%3BCardenas%2C+Victor+M%3BSchulz%2C+Leslie+O&rft.aulast=de+Heer&rft.aufirst=Hendrik&rft.date=2011-05-01&rft.volume=33&rft.issue=2&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Hispanic+Journal+of+Behavioral+Sciences&rft.issn=07399863&rft_id=info:doi/10.1177%2F0739986311406068 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Number of references - 46 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - demography; Smoking; diabetes mellitus; metabolic disorders; Cardiovascular diseases; Children; Ethnic groups DO - http://dx.doi.org/10.1177/0739986311406068 ER - TY - JOUR T1 - Clustering of Strength, Physical Function, Muscle, and Adiposity Characteristics and Risk of Disability in Older Adults AN - 876238959; 14888875 AB - OBJECTIVES: To empirically identify groupings of strength, physical performance, adiposity, and lean mass and test how such groupings of these interrelated measures may relate to disability risk. DESIGN: Prospective Health, Aging and Body Composition Study. PARTICIPANTS: One thousand two hundred sixty-three women and 1,221 men. MEASUREMENTS: Weight, strength (knee extension, grip); walking speed, chair stands, dual X-ray absorptiometry (fat and lean mass for total body, arm, and leg; percent fat), and thigh computed tomography scans (muscle area, muscle density). Analyses were stratified according to sex. Factor analysis reduced these variables into a smaller number of components, and proportional hazards models assessed risk of major disability for the components identified. RESULTS: In both sexes, factor analysis reduced the 14 individual variables into three components that explained 76% to 77% of the data variance: Factor 1, an adiposity component, with strong loading by fat mass, weight, and muscle density; Factor 2, a strength and lean body size component with strong loading by lean mass, weight, and strength; Factor 3, a physical performance component with positive loading by walking speed and chair stand performance. Factor 1 (adiposity) and Factor 3 (performance) but not Factor 2 (strength and lean body size) were associated with disability over 6.1+/-2.6 years. CONCLUSION: The adiposity and physical performance constructs but not the strength and lean body size construct were associated with disability risk, suggesting that adiposity and performance should be considered as risk factors for disability.Original Abstract: SETTING: Two U.S. clinical centers. JF - Journal of the American Geriatrics Society AU - Cawthon, Peggy M AU - Fox, Kathleen M AU - Gandra, Shravanthi R AU - Delmonico, Matthew J AU - Chiou, Chiun-Fang AU - Anthony, Mary S AU - Caserotti, Paolo AU - Kritchevsky, Stephen B AU - Newman, Anne B AU - Goodpaster, Bret H AU - Satterfield, Suzanne AU - Cummings, Steven R AU - Harris, Tamara B AD - From the*Research Institute, California Pacific Medical Center, San Francisco, California; Strategic Healthcare Solutions, LLC, Monkton, Maryland; Amgen, Thousand Oaks, California; University of Rhode Island, Kingston, Rhode Island; [par]Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and University of Tennessee, Memphis, Tennessee. Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 781 EP - 787 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 59 IS - 5 SN - 0002-8614, 0002-8614 KW - Risk Abstracts KW - Muscles KW - aging KW - body size KW - computed tomography KW - disabilities KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876238959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Clustering+of+Strength%2C+Physical+Function%2C+Muscle%2C+and+Adiposity+Characteristics+and+Risk+of+Disability+in+Older+Adults&rft.au=Cawthon%2C+Peggy+M%3BFox%2C+Kathleen+M%3BGandra%2C+Shravanthi+R%3BDelmonico%2C+Matthew+J%3BChiou%2C+Chiun-Fang%3BAnthony%2C+Mary+S%3BCaserotti%2C+Paolo%3BKritchevsky%2C+Stephen+B%3BNewman%2C+Anne+B%3BGoodpaster%2C+Bret+H%3BSatterfield%2C+Suzanne%3BCummings%2C+Steven+R%3BHarris%2C+Tamara+B&rft.aulast=Cawthon&rft.aufirst=Peggy&rft.date=2011-05-01&rft.volume=59&rft.issue=5&rft.spage=781&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2011.03389.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Document feature - figure 2 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - computed tomography; disabilities; Muscles; body size; aging DO - http://dx.doi.org/10.1111/j.1532-5415.2011.03389.x ER - TY - JOUR T1 - Medical student bias and care recommendations for an obese versus non-obese virtual patient AN - 876224945; 14865500 AB - Objective: This study examined the independent effect of a patient's weight on medical students' attitudes, beliefs and interpersonal behavior toward the patient, in addition to the clinical recommendations they make for her care.Design:A total of 76 clinical-level medical students were randomly assigned to interact with a digital, virtual female patient who was visibly either obese or non-obese. Methods: Interactions with the patient took place in an immersive virtual (virtual reality) clinical environment that allowed standardization of all patient behaviors and characteristics except for weight. Visual contact behavior was automatically recorded during the interaction. Afterward, participants filled out a battery of self-report questionnaires. Results: Analyses revealed more negative stereotyping, less anticipated patient adherence, worse perceived health, more responsibility attributed for potentially weight-related presenting complaints and less visual contact directed toward the obese version of a virtual patient than the non-obese version of the patient. In contrast, there was no clear evidence of bias in clinical recommendations made for the patient's care. Conclusion: Biases in attitudes, beliefs and interpersonal behavior have important implications because they can influence the tone of clinical encounters and rapport in the patient-provider relationship, which can have important downstream consequences. Gaining a clear understanding of the nature and source of weight bias in the clinical encounter is an important first step toward the development of strategies to address it. JF - International Journal of Obesity AU - Persky, S AU - Eccleston, C P AD - Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, MD, USA Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 728 EP - 735 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 35 IS - 5 SN - 0307-0565, 0307-0565 KW - Physical Education Index; Health & Safety Science Abstracts KW - Analysis KW - Attitudes KW - Behavior KW - Obesity KW - Patients KW - Perception KW - Standards KW - Strategy KW - Students KW - Virtual reality KW - Weight KW - attitudes KW - downstream KW - obesity KW - responsibility KW - H 12000:Epidemiology and Public Health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876224945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Obesity&rft.atitle=Medical+student+bias+and+care+recommendations+for+an+obese+versus+non-obese+virtual+patient&rft.au=Persky%2C+S%3BEccleston%2C+C+P&rft.aulast=Persky&rft.aufirst=S&rft.date=2011-05-01&rft.volume=35&rft.issue=5&rft.spage=728&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Obesity&rft.issn=03070565&rft_id=info:doi/10.1038%2Fijo.2010.173 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Obesity; Attitudes; Virtual reality; Weight; Behavior; Analysis; Strategy; Patients; Students; Perception; downstream; obesity; Standards; attitudes; responsibility DO - http://dx.doi.org/10.1038/ijo.2010.173 ER - TY - JOUR T1 - The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells AN - 874191971; 14865582 AB - Although hematopoietic stem cells (HSCs) are the most thoroughly characterized type of adult stem cell, the intricate molecular machinery that regulates their self-renewal properties remains elusive. Here we showed that the E3 ubiquitin ligase Itch negatively regulated the development and function of HSCs. Itch super(-/-) mice had HSCs with enhanced frequency, competence and long-term repopulating activity. Itch-deficient HSCs showed accelerated proliferation rates and sustained progenitor properties, as well as more signaling by the transcription factor Notch1, due to more accumulation of activated Notch1. Knockdown of Notch1 in Itch-mutant HSCs resulted in reversion of the phenotype. Thus, we identify Itch as a previously unknown negative regulator of HSC homeostasis and function. JF - Nature Immunology AU - Rathinam, Chozhavendan AU - Matesic, Lydia E AU - Flavell, Richard A AD - 1] Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA. [2] National Institutes of Health, Center for Biomedical Research Excellence in Stem Cell Biology, Roger Williams Medical Center, Boston University School of Medicine, Providence, Rhode Island, USA. Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 399 EP - 407 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 12 IS - 5 SN - 1529-2908, 1529-2908 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Stem cells KW - Transcription factors KW - Reversion KW - Homeostasis KW - Ubiquitin-protein ligase KW - W 30965:Miscellaneous, Reviews KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874191971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Immunology&rft.atitle=The+E3+ligase+Itch+is+a+negative+regulator+of+the+homeostasis+and+function+of+hematopoietic+stem+cells&rft.au=Rathinam%2C+Chozhavendan%3BMatesic%2C+Lydia+E%3BFlavell%2C+Richard+A&rft.aulast=Rathinam&rft.aufirst=Chozhavendan&rft.date=2011-05-01&rft.volume=12&rft.issue=5&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Nature+Immunology&rft.issn=15292908&rft_id=info:doi/10.1038%2Fni.2021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Stem cells; Transcription factors; Reversion; Homeostasis; Ubiquitin-protein ligase DO - http://dx.doi.org/10.1038/ni.2021 ER - TY - JOUR T1 - Taking humor seriously: talking about drinking in Native American focus groups AN - 870440271; 4201758 AB - Focus groups provide a source of data that highlight community ideas on a topic of interest. How interview data will be utilized varies by project. With this in mind, we identify ways that focus group data from a particular population (Native American) articulate a health issue of individual tribal concern (alcohol consumption). Taking our analytic framework from linguistics, one of the four fields of inquiry in anthropology, we examine format ties and the performance of humor as stylistic features of tribal focus groups and illustrate how linguistic devices can be used in analyzing aspects of adolescent and adult drinking. Focus group data require systematic review and analysis to identify useful findings that can lead to inquiry points to initiate collaborative work with local experts before the data can be developed and configured into effective program initiatives. Reprinted by permission of Harwood Academic Publishers, Taylor and Francis Ltd JF - Medical anthropology AU - Bletzer, Keith AU - Yuan, Nicole AU - Koss, Mary AU - Polacca, Mona AU - Eaves, Emery AU - Goldman, David AD - Arizona State University ; University of Arizona ; National Institute on Alcohol Abuse and Alcoholism, Maryland Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 295 EP - 318 VL - 30 IS - 3 SN - 0145-9740, 0145-9740 KW - Anthropology KW - Tribal society KW - Humour KW - Alcoholism KW - Linguistic anthropology KW - Focus groups KW - Health KW - Indigenous populations KW - Interviews KW - U.S.A. KW - North Amerindians UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/870440271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+anthropology&rft.atitle=Taking+humor+seriously%3A+talking+about+drinking+in+Native+American+focus+groups&rft.au=Bletzer%2C+Keith%3BYuan%2C+Nicole%3BKoss%2C+Mary%3BPolacca%2C+Mona%3BEaves%2C+Emery%3BGoldman%2C+David&rft.aulast=Bletzer&rft.aufirst=Keith&rft.date=2011-05-01&rft.volume=30&rft.issue=3&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Medical+anthropology&rft.issn=01459740&rft_id=info:doi/10.1080%2F01459740.2011.560584 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 6125 6085; 6832 10919; 913 561 6220; 8737; 5077 10519 3279 971 3286 10919; 6314 9846; 5772; 7425 1077; 12993 11979; 433 293 14 DO - http://dx.doi.org/10.1080/01459740.2011.560584 ER - TY - JOUR T1 - Super-resolution microscopy for nanosensing AN - 869591044; 14821201 AB - The recent advances in optical microscopy enable the simultaneous visualization of thousands of structural and signaling molecules as they dynamically rearrange within living cells. Super-resolution microscopy offers an unprecedented opportunity to define the molecular mechanisms of nanosensing through direct observation of protein movement. This technology provides a real-time readout of how genetically targeted molecular perturbations affect protein interactions. As we strive to meet the challenge offered by the opportunity to ask questions about the mechanism of cell that we never thought we could answer, we need to be aware that the new technologies are still evolving. The current limitations of each technique need to be considered when matching them to specific biological questions. In this review, we briefly describe the principles of super-resolution optical microscopy and focus on comparing the characteristics of each technique that are important for their use in studying nanosensing in the cellular microenvironment. WIREs Nanomed Nanobiotechnol 2011 3 247-255 JF - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology AU - Galbraith, James A AU - Galbraith, Catherine G AD - NINDS, National Institutes of Health, Bethesda, MD, USA, jgalbrai@ninds.nih.gov Y1 - 2011/05/01/ PY - 2011 DA - 2011 May 01 SP - 247 EP - 255 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK VL - 3 IS - 3 SN - 1939-0041, 1939-0041 KW - Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Microscopy KW - Microenvironments KW - Protein interaction KW - nanotechnology KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869591044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.atitle=Super-resolution+microscopy+for+nanosensing&rft.au=Galbraith%2C+James+A%3BGalbraith%2C+Catherine+G&rft.aulast=Galbraith&rft.aufirst=James&rft.date=2011-05-01&rft.volume=3&rft.issue=3&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.issn=19390041&rft_id=info:doi/10.1002%2Fwnan.130 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Microscopy; Microenvironments; Protein interaction; nanotechnology DO - http://dx.doi.org/10.1002/wnan.130 ER - TY - JOUR T1 - Molecular probes for the A sub(2A adenosine receptor based on a pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine scaffold) AN - 867749951; 14782988 AB - Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine derivatives such as SCH 442416 display high affinity and selectivity as antagonists for the human A sub(2A adenosine receptor (AR). We extended ether-linked chain substituents at the p-position of the phenyl group using optimized O-alkylation. The conjugates included an ester, carboxylic acid and amines (for amide condensation), an alkyne (for click chemistry), a fluoropropyl group (for [super]18F incorporation), and fluorophore reporter groups (e.g., BODIPY conjugate 14, K) sub(i) 15 nM). The potent and A sub(2AAR-selective N-aminoethylacetamide 7 and N-[2-(2-aminoethyl)-aminoethyl]acetamide 8 congeners were coupled to polyamidoamine (PAMAM) G3.5 dendrimers, and the multivalent conjugates displayed high A) sub(2)AAR affinity. Theoretical docking of an AlexaFluor conjugate to the receptor X-ray structure highlighted the key interactions between the heterocyclic core and the binding pocket of the A sub(2AAR as well as the distal anchoring of the fluorophore. In conclusion, we have synthesized a family of high affinity functionalized congeners as pharmacological probes for studying the A) sub(2)AAR. JF - Bioorganic and Medicinal Chemistry Letters AU - Kumar, TSanthosh AU - Mishra, Shilpi AU - Deflorian, Francesca AU - Yoo, Lena S AU - Phan, Khai AU - Kecskes, Miklos AU - Szabo, Angela AU - Shinkre, Bidhan AU - Gao, Zhan-Guo AU - Trenkle, William AU - Jacobson, Kenneth A AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 8A, Rm. B1A-19, Bethesda, MD 20892, USA, kajacobs@helix.nih.gov kajacobs@helix.nih.gov Y1 - 2011/05/01/ PY - 2011 DA - 2011 May 01 SP - 2740 EP - 2745 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 21 IS - 9 SN - 0960-894X, 0960-894X KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Adenosine receptors KW - Congeners KW - W 30910:Imaging KW - N 14845:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867749951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Molecular+probes+for+the+A+sub%282A+adenosine+receptor+based+on+a+pyrazolo%5B4%2C3-e%5D%5B1%2C2%2C4%5Dtriazolo%5B1%2C5-c%5Dpyrimidin-5-amine+scaffold%29&rft.au=Kumar%2C+TSanthosh%3BMishra%2C+Shilpi%3BDeflorian%2C+Francesca%3BYoo%2C+Lena+S%3BPhan%2C+Khai%3BKecskes%2C+Miklos%3BSzabo%2C+Angela%3BShinkre%2C+Bidhan%3BGao%2C+Zhan-Guo%3BTrenkle%2C+William%3BJacobson%2C+Kenneth+A&rft.aulast=Kumar&rft.aufirst=TSanthosh&rft.date=2011-05-01&rft.volume=21&rft.issue=9&rft.spage=2740&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2010.11.082 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2014-04-03 N1 - SubjectsTermNotLitGenreText - Congeners DO - http://dx.doi.org/10.1016/j.bmcl.2010.11.082 ER - TY - JOUR T1 - Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 AN - 867733779; 14783005 AB - Based on SAR in the alkyne class of mGlu5 receptor negative allosteric modulators and a set of amide-based positive allosteric modulators, optimized substitution of the aryl 'b' ring was used to create substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides. Results from an mGlu5 receptor functional assay, using calcium fluorescence, revealed varying efficacies and potencies that provide evidence that subtle changes in compounds within a close structural class can have marked effects on functional activity including switches in modes of efficacy (i.e., negative to positive allosteric modulation). JF - Bioorganic and Medicinal Chemistry Letters AU - Zou, Mu-Fa AU - Cao, Jianjing AU - Rodriguez, Alice L AU - Conn, PJeffrey AU - Newman, Amy Hauck AD - Medicinal Chemistry Section, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive Baltimore, MD 21224, United States, anewman@intra.nida.nih.gov Y1 - 2011/05/01/ PY - 2011 DA - 2011 May 01 SP - 2650 EP - 2654 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 21 IS - 9 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - Glutamic acid receptors (metabotropic) KW - Fluorescence KW - Calcium KW - Allosteric properties KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867733779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Design+and+synthesis+of+substituted+N-%281%2C3-diphenyl-1H-pyrazol-5-yl%29benzamides+as+positive+allosteric+modulators+of+the+metabotropic+glutamate+receptor+subtype+5&rft.au=Zou%2C+Mu-Fa%3BCao%2C+Jianjing%3BRodriguez%2C+Alice+L%3BConn%2C+PJeffrey%3BNewman%2C+Amy+Hauck&rft.aulast=Zou&rft.aufirst=Mu-Fa&rft.date=2011-05-01&rft.volume=21&rft.issue=9&rft.spage=2650&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2010.12.110 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Glutamic acid receptors (metabotropic); Calcium; Fluorescence; Allosteric properties DO - http://dx.doi.org/10.1016/j.bmcl.2010.12.110 ER - TY - JOUR T1 - Effects of frozen storage and sample temperature on water compartmentation and multiexponential transverse relaxation in cartilage AN - 864959872; 14694663 AB - Multiexponential transverse relaxation in tissue has been interpreted as a marker of water compartmentation. Articular cartilage has been reported to exhibit such relaxation in several studies, with the relative contributions of tissue heterogeneity and tissue microstructure remaining unspecified. In bovine nasal cartilage, conflicting data regarding the existence of multiexponential relaxation have been reported. Imaging and analysis artifacts as well as rapid chemical exchange between tissue compartments have been identified as potential causes for this discrepancy. Here, we find that disruption of cartilage microstructure by freeze-thawing can greatly alter the character of transverse relaxation in this tissue. We conclude that fresh cartilage exhibits multiexponential relaxation based upon its microstructural water compartments, but that multiexponentiality can be lost or rendered undetectable by freeze-thawing. In addition, we find that increasing chemical exchange by raising sample temperature from 4[deg]C to 37[deg]C does not substantially limit the ability to detect multiexponential relaxation. JF - Magnetic Resonance Imaging AU - Reiter, David A AU - Peacock, Andrew AU - Spencer, Richard G AD - Magnetic Resonance Imaging and Spectroscopy Section, GRC 4D-08, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA, reiterda@mail.nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 561 EP - 567 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 29 IS - 4 SN - 0730-725X, 0730-725X KW - Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Cartilage (articular) KW - Compartmentation KW - Data processing KW - Freeze-thawing KW - Magnetic resonance imaging KW - Temperature effects KW - Water temperature KW - W 30910:Imaging KW - T 2030:Cartilage and Cartilage Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864959872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=Effects+of+frozen+storage+and+sample+temperature+on+water+compartmentation+and+multiexponential+transverse+relaxation+in+cartilage&rft.au=Reiter%2C+David+A%3BPeacock%2C+Andrew%3BSpencer%2C+Richard+G&rft.aulast=Reiter&rft.aufirst=David&rft.date=2011-05-01&rft.volume=29&rft.issue=4&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2010.10.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-06-29 N1 - SubjectsTermNotLitGenreText - Temperature effects; Compartmentation; Data processing; Magnetic resonance imaging; Water temperature; Cartilage (articular); Freeze-thawing DO - http://dx.doi.org/10.1016/j.mri.2010.10.011 ER - TY - JOUR T1 - Phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix. AN - 864780682; 21444871 AB - To determine whether addition of gemcitabine to concurrent cisplatin chemoradiotherapy and as adjuvant chemotherapy with cisplatin improves progression-free survival (PFS) at 3 years compared with current standard of care in locally advanced cervical cancer. Eligible chemotherapy- and radiotherapy-naive patients with stage IIB to IVA disease and Karnofsky performance score ≥ 70 were randomly assigned to arm A (cisplatin 40 mg/m(2) and gemcitabine 125 mg/m(2) weekly for 6 weeks with concurrent external-beam radiotherapy [XRT] 50.4 Gy in 28 fractions, followed by brachytherapy [BCT] 30 to 35 Gy in 96 hours, and then two adjuvant 21-day cycles of cisplatin, 50 mg/m(2) on day 1, plus gemcitabine, 1,000 mg/m(2) on days 1 and 8) or to arm B (cisplatin and concurrent XRT followed by BCT only; dosing same as for arm A). Between May 2002 and March 2004, 515 patients were enrolled (arm A, n = 259; arm B, n = 256). PFS at 3 years was significantly improved in arm A versus arm B (74.4% v 65.0%, respectively; P = .029), as were overall PFS (log-rank P = .0227; hazard ratio [HR], 0.68; 95% CI, 0.49 to 0.95), overall survival (log-rank P = .0224; HR, 0.68; 95% CI, 0.49 to 0.95), and time to progressive disease (log-rank P = .0012; HR, 0.54; 95% CI, 0.37 to 0.79). Grade 3 and 4 toxicities were more frequent in arm A than in arm B (86.5% v 46.3%, respectively; P < .001), including two deaths possibly related to treatment toxicity in arm A. Gemcitabine plus cisplatin chemoradiotherapy followed by BCT and adjuvant gemcitabine/cisplatin chemotherapy improved survival outcomes with increased but clinically manageable toxicity when compared with standard treatment. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Dueñas-González, Alfonso AU - Zarbá, Juan J AU - Patel, Firuza AU - Alcedo, Juan C AU - Beslija, Semir AU - Casanova, Luis AU - Pattaranutaporn, Pittayapoom AU - Hameed, Shahid AU - Blair, Julie M AU - Barraclough, Helen AU - Orlando, Mauro AD - National Cancer Institute/Institute of Biomedical Research, Universidad Nacional Autónoma de México, México City, México. Y1 - 2011/05/01/ PY - 2011 DA - 2011 May 01 SP - 1678 EP - 1685 VL - 29 IS - 13 KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Infant KW - Drug Administration Schedule KW - Disease-Free Survival KW - Combined Modality Therapy KW - Humans KW - Adult KW - Infant, Newborn KW - Female KW - Chemotherapy, Adjuvant KW - Uterine Cervical Neoplasms -- drug therapy KW - Deoxycytidine -- analogs & derivatives KW - Deoxycytidine -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Uterine Cervical Neoplasms -- radiotherapy KW - Uterine Cervical Neoplasms -- pathology KW - Cisplatin -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864780682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Phase+III%2C+open-label%2C+randomized+study+comparing+concurrent+gemcitabine+plus+cisplatin+and+radiation+followed+by+adjuvant+gemcitabine+and+cisplatin+versus+concurrent+cisplatin+and+radiation+in+patients+with+stage+IIB+to+IVA+carcinoma+of+the+cervix.&rft.au=Due%C3%B1as-Gonz%C3%A1lez%2C+Alfonso%3BZarb%C3%A1%2C+Juan+J%3BPatel%2C+Firuza%3BAlcedo%2C+Juan+C%3BBeslija%2C+Semir%3BCasanova%2C+Luis%3BPattaranutaporn%2C+Pittayapoom%3BHameed%2C+Shahid%3BBlair%2C+Julie+M%3BBarraclough%2C+Helen%3BOrlando%2C+Mauro&rft.aulast=Due%C3%B1as-Gonz%C3%A1lez&rft.aufirst=Alfonso&rft.date=2011-05-01&rft.volume=29&rft.issue=13&rft.spage=1678&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2009.25.9663 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-28 N1 - Date created - 2011-05-02 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00191100; ClinicalTrials.gov N1 - SuppNotes - Comment In: J Clin Oncol. 2011 May 1;29(13):1654-6 [21444860] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1200/JCO.2009.25.9663 ER - TY - JOUR T1 - NCOA6 differentially regulates the expression of the CYP2C9 and CYP3A4 genes. AN - 863431472; 21292004 AB - CYP2Cs and CYP3A4 sub families of enzymes of the Cytochrome P450 super family metabolize clinically prescribed therapeutics. Constitutive and induced expressions of these enzymes are under the control of HNF4α and rifampicin activated PXR. In the present study, we show a mechanism for ligand dependent synergistic cross talk between PXR and HNF4α. Two-hybrid screening identified NCOA6 as a HNF4α interacting protein. NCOA6 was also found to interact with PXR through the first LXXLL motif in GST pull down and mammalian two hybrid assays. NCOA6 enhances the synergistic activation of CYP2C9 and CYP3A4 promoter activity by PXR and HNF4α in the presence of rifampicin. However silencing NCOA6 abrogated the synergistic activation and induction of CYP2C9 by PXR-HNF4α but not of CYP3A4. ChIP analysis revealed that NCOA6 could bridge HNF4α and PXR binding sites of the CYP2C9 promoter. Our results indicate that NCOA6 is responsible for the synergistic activation of CYP2C9 by HNF4α and PXR and NCOA6 differentially regulates CYP2C9 and CYP3A4 gene expression though both the genes are regulated by the same nuclear receptors. Published by Elsevier Ltd. JF - Pharmacological research AU - Surapureddi, Sailesh AU - Rana, Ritu AU - Goldstein, Joyce A AD - Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, United States. Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 405 EP - 413 VL - 63 IS - 5 KW - Hepatocyte Nuclear Factor 4 KW - 0 KW - NCOA6 protein, human KW - Nuclear Receptor Coactivators KW - Receptors, Steroid KW - pregnane X receptor KW - CYP2C9 protein, human KW - EC 1.14.13.- KW - Cytochrome P-450 CYP2C9 KW - CYP3A4 protein, human KW - EC 1.14.13.67 KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP3A KW - Index Medicus KW - Protein Interaction Mapping KW - Hep G2 Cells KW - Humans KW - Two-Hybrid System Techniques KW - Receptors, Steroid -- metabolism KW - Chromatin Immunoprecipitation KW - Hepatocyte Nuclear Factor 4 -- metabolism KW - Nuclear Receptor Coactivators -- genetics KW - Nuclear Receptor Coactivators -- metabolism KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Gene Expression Regulation, Enzymologic KW - Cytochrome P-450 CYP3A -- metabolism KW - Cytochrome P-450 CYP3A -- genetics KW - Aryl Hydrocarbon Hydroxylases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863431472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacological+research&rft.atitle=NCOA6+differentially+regulates+the+expression+of+the+CYP2C9+and+CYP3A4+genes.&rft.au=Surapureddi%2C+Sailesh%3BRana%2C+Ritu%3BGoldstein%2C+Joyce+A&rft.aulast=Surapureddi&rft.aufirst=Sailesh&rft.date=2011-05-01&rft.volume=63&rft.issue=5&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Pharmacological+research&rft.issn=1096-1186&rft_id=info:doi/10.1016%2Fj.phrs.2011.01.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-16 N1 - Date created - 2011-04-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2000 May;20(9):2951-8 [10757780] J Biol Chem. 2000 May 5;275(18):13510-6 [10788465] J Biol Chem. 2000 May 19;275(20):15122-7 [10748001] Drug Metab Dispos. 2001 Mar;29(3):242-51 [11181490] Hepatology. 2001 Mar;33(3):668-75 [11230748] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3375-80 [11248086] Annu Rev Pharmacol Toxicol. 2001;41:815-50 [11264478] J Biol Chem. 2001 Apr 20;276(16):12822-6 [11278292] Mol Pharmacol. 2001 Sep;60(3):427-31 [11502872] Br J Clin Pharmacol. 2001 Oct;52(4):349-55 [11678778] J Biol Chem. 2002 Jan 4;277(1):209-17 [11679585] J Lipid Res. 2002 Mar;43(3):359-64 [11893771] Mol Endocrinol. 2002 May;16(5):977-86 [11981033] Mol Pharmacol. 2002 Sep;62(3):737-46 [12181452] J Pharmacol Exp Ther. 2002 Oct;303(1):412-23 [12235278] Br J Clin Pharmacol. 2002 Oct;54(4):349-56 [12392581] Nat Med. 2003 Feb;9(2):220-4 [12514743] Drug Metab Dispos. 2003 Apr;31(4):421-31 [12642468] J Biol Chem. 2003 Jul 11;278(28):25281-4 [12754253] J Pharmacol Exp Ther. 2004 Feb;308(2):495-501 [14600250] Drug Metab Dispos. 2004 May;32(5):512-8 [15100173] Eur J Clin Pharmacol. 1975 Dec 19;9(2-3):219-27 [1233266] Br J Clin Pharmacol. 1985 Oct;20(4):323-6 [4074601] Curr Opin Genet Dev. 1992 Apr;2(2):256-9 [1638120] Pharmacogenetics. 1994 Dec;4(6):285-99 [7704034] Biochemistry. 1995 Jun 27;34(25):8028-36 [7794915] Pharmacogenetics. 1996 Feb;6(1):1-42 [8845856] Pharmacogenetics. 1997 Jun;7(3):211-21 [9241661] Clin Pharmacol Ther. 1998 Mar;63(3):316-23 [9542475] Mol Pharmacol. 1998 Apr;53(4):597-601 [9547348] J Biol Chem. 1999 Mar 5;274(10):6043-6 [10037683] Am J Physiol. 1999 May;276(5 Pt 1):G1181-94 [10330009] Mol Cell Biol. 1999 Sep;19(9):6318-22 [10454578] Mol Cell. 2004 Dec 22;16(6):893-905 [15610733] Mol Cell. 2004 Dec 22;16(6):919-28 [15610735] Cell Metab. 2005 Jan;1(1):6-8 [16054039] J Pharmacol Exp Ther. 2005 Sep;314(3):1125-33 [15919766] Drug Metab Dispos. 2006 May;34(5):756-64 [16455805] J Biol Chem. 2006 Sep 8;281(36):26540-51 [16825189] Steroids. 2007 Mar;72(3):231-46 [17284330] Mol Endocrinol. 2007 Sep;21(9):2099-111 [17595319] J Pharmacol Exp Ther. 2007 Nov;323(2):586-98 [17687072] Mol Cell Biol. 2007 Dec;27(23):8073-86 [17908797] J Biol Chem. 2008 Apr 18;283(16):10425-32 [18303024] Adv Exp Med Biol. 2008;617:591-7 [18497086] Mol Pharmacol. 2008 Sep;74(3):913-23 [18552123] FEBS Lett. 2009 Jun 18;583(12):2126-30 [19467232] Genes Dev. 2000 Dec 1;14(23):3014-23 [11114890] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.phrs.2011.01.013 ER - TY - JOUR T1 - Expression of insulinoma-associated 2 (INSM2) in pancreatic islet cells is regulated by the transcription factors Ngn3 and NeuroD1. AN - 863427035; 21343251 AB - The insulinoma-associated 2 (Insm2) gene is a member of the Snail/Gfi1/Insm1 transcriptional repressor superfamily. However, little is known about how the expression of human INSM2 or mouse Insm2 in neuroendocrine tissues is regulated. Here we report the expression of INSM2/Insm2 in human fetal pancreas and mouse embryos, as well as adult pancreatic islets, and its regulation by two major islet transcription factors. Mutagenesis and chromatin immunoprecipitation analysis demonstrated that the proximal E-boxes of the mouse Insm2 promoter are direct targets of neurogenin 3 and neurogenic differentiation 1 (NeuroD1). Furthermore, we found that endogenous Insm2 expression was activated in Ngn3/NeuroD1-transduced pancreatic epithelial duct cells. Our results suggest that Insm2 plays an important role in the differentiation cascade of Ngn3/NeuroD1 signaling in pancreatic islets. JF - Endocrinology AU - Cai, Tao AU - Chen, Xiang AU - Wang, Rennian AU - Xu, Huan AU - You, Yuhui AU - Zhang, Tao AU - Lan, Michael S AU - Notkins, Abner L AD - National Institute of Dental and Craniofacial Research/National Institutes of Health, Bethesda, Maryland 20892, USA. tcai@mail.nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 1961 EP - 1969 VL - 152 IS - 5 KW - Basic Helix-Loop-Helix Transcription Factors KW - 0 KW - Nerve Tissue Proteins KW - Neurod1 protein, mouse KW - Neurog3 protein, mouse KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Blotting, Northern KW - HeLa Cells KW - Humans KW - Gene Expression KW - Amino Acid Sequence KW - Cell Line, Tumor KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Protein Binding KW - Rats KW - Blotting, Western KW - Pancreas -- metabolism KW - Pancreas -- embryology KW - Molecular Sequence Data KW - Chromatin Immunoprecipitation KW - Mice, Inbred C57BL KW - Pancreas -- growth & development KW - Promoter Regions, Genetic -- genetics KW - Sequence Homology, Amino Acid KW - Gene Expression Regulation, Developmental KW - PC12 Cells KW - Basic Helix-Loop-Helix Transcription Factors -- metabolism KW - Nerve Tissue Proteins -- metabolism KW - Islets of Langerhans -- cytology KW - Nerve Tissue Proteins -- genetics KW - Basic Helix-Loop-Helix Transcription Factors -- genetics KW - Islets of Langerhans -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863427035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Expression+of+insulinoma-associated+2+%28INSM2%29+in+pancreatic+islet+cells+is+regulated+by+the+transcription+factors+Ngn3+and+NeuroD1.&rft.au=Cai%2C+Tao%3BChen%2C+Xiang%3BWang%2C+Rennian%3BXu%2C+Huan%3BYou%2C+Yuhui%3BZhang%2C+Tao%3BLan%2C+Michael+S%3BNotkins%2C+Abner+L&rft.aulast=Cai&rft.aufirst=Tao&rft.date=2011-05-01&rft.volume=152&rft.issue=5&rft.spage=1961&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=1945-7170&rft_id=info:doi/10.1210%2Fen.2010-1065 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-22 N1 - Date created - 2011-04-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Genet. 1999 Nov;23(3):323-8 [10545951] Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13245-50 [15340143] Cancer Res. 2001 Feb 1;61(3):1144-53 [11221845] Mol Cell Biol. 2001 May;21(9):3234-43 [11287626] N Engl J Med. 2001 Sep 27;345(13):971-80 [11575290] Genomics. 2002 Jul;80(1):54-61 [12079283] J Biol Chem. 1992 Jul 25;267(21):15252-7 [1634555] Cancer Res. 1993 Sep 15;53(18):4169-71 [8364910] Am J Pathol. 1994 Sep;145(3):671-84 [7521578] Genes Dev. 1997 Sep 15;11(18):2323-34 [9308961] Mol Cell Probes. 1998 Oct;12(5):283-91 [9778453] EMBO J. 2006 Mar 22;25(6):1344-52 [16511571] Genes Dev. 2006 Sep 1;20(17):2465-78 [16951258] Nature. 2007 Jan 11;445(7124):168-76 [17151600] FEBS Lett. 2007 Mar 6;581(5):949-54 [17300785] Dev Biol. 2007 Sep 1;309(1):1-17 [17559827] J Endocrinol. 2007 Nov;195(2):313-21 [17951542] Differentiation. 2008 Apr;76(4):381-91 [17924961] Diabetologia. 2008 Jul;51(7):1169-80 [18491072] Diabetes. 2008 Oct;57(10):2755-61 [18599526] FASEB J. 2009 Jul;23(7):2024-33 [19246490] J Biol Chem. 2003 Oct 3;278(40):38991-7 [12890672] Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1607-11 [10677506] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/en.2010-1065 ER - TY - JOUR T1 - Latent Class Analysis of Sexual Risk Patterns Among Esquineros (Street Corner Men) a Group of Heterosexually Identified, Socially Marginalized Men in Urban Coastal Peru AN - 863409967; 20694510 AB - We explored patterns of sexual risk behavior among esquineros, heterosexually-identified, socially-marginalized Peruvian men using latent class analysis. We used data from the Peru site of the National Institute of Mental Health (NIMH) Collaborative HIV/STD Prevention Trial which included n = 2,109 heterosexually-identified men. The latent class analysis used seven risk behaviors to group esquineros into risk classes. We identified four latent classes, of which two classes had lower probabilities and two classes had higher probabilities of these risk behaviors. Comparing the two lower risk classes to the two higher risk classes yielded significantly more unprotected sex acts (Chi square P value < 0.001). The risk behaviors in two of the latent classes identified were primarily related to alcohol and drug use. Future HIV/STI prevention interventions may benefit from this information by tailoring messages to fit the observed risk patterns and should focus on drug and alcohol use.[PUBLICATION ABSTRACT] JF - AIDS and Behavior AU - Konda, Kelika A AU - Celentano, David D AU - Kegeles, Susan AU - Coates, Thomas J AU - Caceres, Carlos F Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 862 EP - 8 CY - New York PB - Springer Science & Business Media VL - 15 IS - 4 SN - 10907165 KW - Psychology KW - Sexual behavior KW - Human immunodeficiency virus--HIV KW - Disease prevention KW - Disease transmission KW - Men KW - Peru KW - Sexually Transmitted Diseases -- psychology KW - Young Adult KW - Unsafe Sex KW - Humans KW - Sexual Partners KW - Risk KW - Poverty KW - Adult KW - Interviews as Topic KW - Urban Population KW - HIV Infections -- psychology KW - Female KW - Male KW - Risk-Taking KW - Heterosexuality KW - HIV Infections -- prevention & control KW - Vulnerable Populations -- ethnology KW - Sexually Transmitted Diseases -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863409967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acriminaljusticeperiodicals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Latent+Class+Analysis+of+Sexual+Risk+Patterns+Among+Esquineros+%28Street+Corner+Men%29+a+Group+of+Heterosexually+Identified%2C+Socially+Marginalized+Men+in+Urban+Coastal+Peru&rft.au=Konda%2C+Kelika+A%3BCelentano%2C+David+D%3BKegeles%2C+Susan%3BCoates%2C+Thomas+J%3BCaceres%2C+Carlos+F&rft.aulast=Konda&rft.aufirst=Kelika&rft.date=2011-05-01&rft.volume=15&rft.issue=4&rft.spage=862&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-010-9772-2 LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2011 N1 - Last updated - 2014-08-30 N1 - CODEN - AIBEFC N1 - SubjectsTermNotLitGenreText - Peru DO - http://dx.doi.org/10.1007/s10461-010-9772-2 ER - TY - JOUR T1 - Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia. AN - 862793407; 21460829 AB - Cannabinoids enhance the function of glycine receptors (GlyRs). However, little is known about the mechanisms and behavioral implication of cannabinoid-GlyR interaction. Using mutagenesis and NMR analysis, we have identified a serine at 296 in the GlyR protein critical for the potentiation of I(Gly) by Δ(9)-tetrahydrocannabinol (THC), a major psychoactive component of marijuana. The polarity of the amino acid residue at 296 and the hydroxyl groups of THC are critical for THC potentiation. Removal of the hydroxyl groups of THC results in a compound that does not affect I(Gly) when applied alone but selectively antagonizes cannabinoid-induced potentiating effect on I(Gly) and analgesic effect in a tail-flick test in mice. The cannabinoid-induced analgesia is absent in mice lacking α3GlyRs but not in those lacking CB1 and CB2 receptors. These findings reveal a new mechanism underlying cannabinoid potentiation of GlyRs, which could contribute to some of the cannabis-induced analgesic and therapeutic effects. JF - Nature chemical biology AU - Xiong, Wei AU - Cheng, Kejun AU - Cui, Tanxing AU - Godlewski, Grzegorz AU - Rice, Kenner C AU - Xu, Yan AU - Zhang, Li AD - Laboratory for Integrative Neuroscience, US National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 296 EP - 303 VL - 7 IS - 5 KW - Cannabinoids KW - 0 KW - GLRA2 protein, human KW - Receptor, Cannabinoid, CB1 KW - Receptor, Cannabinoid, CB2 KW - Receptors, Glycine KW - glycine receptor alpha1 KW - glycine receptor alpha3 subunit KW - Serine KW - 452VLY9402 KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Receptor, Cannabinoid, CB2 -- metabolism KW - Animals KW - Humans KW - HEK293 Cells KW - Dronabinol -- pharmacology KW - Receptor, Cannabinoid, CB1 -- metabolism KW - Mice KW - Time Factors KW - Serine -- metabolism KW - Serine -- chemistry KW - Mutagenesis KW - Magnetic Resonance Spectroscopy KW - Receptors, Glycine -- metabolism KW - Cannabis -- metabolism KW - Analgesia -- methods KW - Cannabinoids -- pharmacology KW - Receptors, Glycine -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862793407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+chemical+biology&rft.atitle=Cannabinoid+potentiation+of+glycine+receptors+contributes+to+cannabis-induced+analgesia.&rft.au=Xiong%2C+Wei%3BCheng%2C+Kejun%3BCui%2C+Tanxing%3BGodlewski%2C+Grzegorz%3BRice%2C+Kenner+C%3BXu%2C+Yan%3BZhang%2C+Li&rft.aulast=Xiong&rft.aufirst=Wei&rft.date=2011-05-01&rft.volume=7&rft.issue=5&rft.spage=296&rft.isbn=&rft.btitle=&rft.title=Nature+chemical+biology&rft.issn=1552-4469&rft_id=info:doi/10.1038%2Fnchembio.552 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-16 N1 - Date created - 2011-04-19 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 113635245; PubChem-Substance; 113635232; 113635246; 113635233; 113635243; 113635234; 113635244; 113635235; 113635241; 113635242; 113635230; 113635231; 113635240; 113635228; 113635237; 113635236; 113635248; 113635239; 113635247; 113635229; 113635238 N1 - SuppNotes - Cited By: Eur J Pharmacol. 2000 May 19;396(2-3):141-9 [10822068] Adv Exp Med Biol. 2007;601:395-413 [17713029] Biophys J. 2002 Jul;83(1):252-62 [12080117] Trends Pharmacol Sci. 2002 Nov;23(11):519-27 [12413807] J Neurosci. 2003 Sep 3;23(22):8051-9 [12954867] J Biol Chem. 2003 Nov 21;278(47):46583-9 [12970351] Nature. 2004 Jan 15;427(6971):260-5 [14712238] Science. 2004 May 7;304(5672):884-7 [15131310] J Comp Neurol. 1982 Mar 20;206(1):9-16 [7096630] Brain Res. 1992 Apr 24;578(1-2):8-12 [1324767] Nat Genet. 1993 Dec;5(4):351-8 [8298642] Ann Neurol. 1995 Jul;38(1):85-91 [7611730] J Pharmacol Exp Ther. 1996 May;277(2):586-94 [8627535] J Pharmacol Exp Ther. 1998 Sep;286(3):1301-8 [9732392] Science. 1999 Jan 15;283(5400):401-4 [9888857] Proc Natl Acad Sci U S A. 1999 May 11;96(10):5780-5 [10318961] EMBO J. 1999 Sep 1;18(17):4711-21 [10469650] Biochemistry. 2005 Jun 21;44(24):8790-800 [15952785] J Pharmacol Exp Ther. 2005 Jul;314(1):329-37 [15831444] Int Rev Neurobiol. 2005;65:53-87 [16140053] Cell Mol Life Sci. 2005 Sep;62(18):2027-35 [15968463] Bioinformatics. 2006 Jan 15;22(2):195-201 [16301204] Mol Pharmacol. 2006 Mar;69(3):991-7 [16332990] Pharmacol Ther. 2006 Jul;111(1):114-44 [16584786] Mol Cell Biol. 2006 Aug;26(15):5728-34 [16847326] Pharmacol Rev. 2006 Sep;58(3):389-462 [16968947] Biochem Pharmacol. 2007 Jan 15;73(2):165-74 [16959219] Chem Biodivers. 2007 Aug;4(8):1770-804 [17712819] Mol Pharmacol. 2007 Oct;72(4):1024-32 [17628012] Mol Pharmacol. 2008 Feb;73(2):314-22 [17993512] Sci Signal. 2008;1(28):re7 [18632551] Biochem Pharmacol. 2008 Oct 15;76(8):1014-23 [18755158] J Phys Chem B. 2008 Nov 13;112(45):14312-8 [18821786] Nature. 2009 Jan 1;457(7225):115-8 [18987630] Neuropharmacology. 2009 Jan;56(1):303-9 [18721822] Nature. 2009 Mar 26;458(7237):394-5 [19325596] Pharmacology. 2009;83(4):217-22 [19204413] Pharmacology. 2009;83(5):270-4 [19307742] Biophys J. 2009 Jun 17;96(12):4916-24 [19527650] Vitam Horm. 2009;81:315-35 [19647117] Science. 2009 Aug 7;325(5941):760-4 [19661434] Trends Pharmacol Sci. 2009 Oct;30(10):515-27 [19729208] Neurosci Lett. 2010 Jan 22;469(2):237-42 [19995593] Eur J Neurosci. 2010 Jan;31(2):225-37 [20074214] Comment In: Nat Chem Biol. 2011 May;7(5):249-50 [21502945] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/nchembio.552 ER - TY - JOUR T1 - Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. AN - 862790951; 21362439 AB - The human ether-a-go-go-related gene (hERG) channel, a member of a family of voltage-gated potassium (K(+)) channels, plays a critical role in the repolarization of the cardiac action potential. The reduction of hERG channel activity as a result of adverse drug effects or genetic mutations may cause QT interval prolongation and potentially leads to acquired long QT syndrome. Thus, screening for hERG channel activity is important in drug development. Cardiotoxicity associated with the inhibition of hERG channels by environmental chemicals is also a public health concern. To assess the inhibitory effects of environmental chemicals on hERG channel function, we screened the National Toxicology Program (NTP) collection of 1408 compounds by measuring thallium influx into cells through hERG channels. Seventeen compounds with hERG channel inhibition were identified with IC(50) potencies ranging from 0.26 to 22μM. Twelve of these compounds were confirmed as hERG channel blockers in an automated whole cell patch clamp experiment. In addition, we investigated the structure-activity relationship of seven compounds belonging to the quaternary ammonium compound (QAC) series on hERG channel inhibition. Among four active QAC compounds, tetra-n-octylammonium bromide was the most potent with an IC(50) value of 260nM in the thallium influx assay and 80nM in the patch clamp assay. The potency of this class of hERG channel inhibitors appears to depend on the number and length of their aliphatic side-chains surrounding the charged nitrogen. Profiling environmental compound libraries for hERG channel inhibition provides information useful in prioritizing these compounds for cardiotoxicity assessment in vivo. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Xia, Menghang AU - Shahane, Sampada A AU - Huang, Ruili AU - Titus, Steven A AU - Shum, Enoch AU - Zhao, Yong AU - Southall, Noel AU - Zheng, Wei AU - Witt, Kristine L AU - Tice, Raymond R AU - Austin, Christopher P AD - NIH Chemical Genomics Center, National Institutes of Health, Bethesda, MD 20892-3370, USA. mxia@mail.nih.gov Y1 - 2011/05/01/ PY - 2011 DA - 2011 May 01 SP - 250 EP - 258 VL - 252 IS - 3 KW - Ether-A-Go-Go Potassium Channels KW - 0 KW - Quaternary Ammonium Compounds KW - Index Medicus KW - Arrhythmias, Cardiac -- prevention & control KW - Arrhythmias, Cardiac -- chemically induced KW - Patch-Clamp Techniques KW - Cell Survival -- drug effects KW - Humans KW - Cell Line, Tumor KW - Inhibitory Concentration 50 KW - Drug Evaluation, Preclinical KW - Structure-Activity Relationship KW - Quaternary Ammonium Compounds -- adverse effects KW - Ether-A-Go-Go Potassium Channels -- metabolism KW - Ether-A-Go-Go Potassium Channels -- antagonists & inhibitors KW - Quaternary Ammonium Compounds -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862790951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Identification+of+quaternary+ammonium+compounds+as+potent+inhibitors+of+hERG+potassium+channels.&rft.au=Xia%2C+Menghang%3BShahane%2C+Sampada+A%3BHuang%2C+Ruili%3BTitus%2C+Steven+A%3BShum%2C+Enoch%3BZhao%2C+Yong%3BSouthall%2C+Noel%3BZheng%2C+Wei%3BWitt%2C+Kristine+L%3BTice%2C+Raymond+R%3BAustin%2C+Christopher+P&rft.aulast=Xia&rft.aufirst=Menghang&rft.date=2011-05-01&rft.volume=252&rft.issue=3&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2011.02.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-11 N1 - Date created - 2011-04-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Res. 2007 Nov;105(3):414-29 [17692309] Acta Pharmacol Sin. 2007 Jul;28(7):959-67 [17588331] Environ Health Perspect. 2008 Mar;116(3):284-91 [18335092] Drugs. 2008;68(15):2183-94 [18840006] Mol Pharmacol. 2008 Nov;74(5):1443-52 [18701618] Risk Anal. 2009 Apr;29(4):485-7; discussion 492-7 [19076321] Anal Biochem. 2009 Nov 1;394(1):30-8 [19583963] Cochrane Database Syst Rev. 2009;(4):CD007655 [19821434] Toxicol Sci. 2009 Nov;112(1):153-63 [19502547] Altern Med Rev. 2009 Dec;14(4):347-59 [20030461] FEBS Lett. 2010 May 17;584(10):2049-56 [20102714] J Mol Cell Cardiol. 2001 May;33(5):835-49 [11343409] Life Sci. 2000 Sep 29;67(19):2393-401 [11065186] Trends Pharmacol Sci. 2001 May;22(5):240-6 [11339975] Environ Res. 2002 Jun;89(2):146-64 [12123648] Cardiovasc Res. 2003 Apr 1;58(1):32-45 [12667944] Naunyn Schmiedebergs Arch Pharmacol. 2003 Jul;368(1):41-8 [12827215] Anal Biochem. 2004 Apr 1;327(1):74-81 [15033513] Eur Biophys J. 2004 Apr;33(2):89-97 [13680209] Assay Drug Dev Technol. 2003 Feb;1(1 Pt 2):127-35 [15090139] Cancer Biol Ther. 2004 Jan;3(1):29-35 [14726713] Aquat Toxicol. 2004 Feb 25;66(3):319-29 [15129773] Eur Biophys J. 2004 May;33(3):194-200 [14608450] Am J Cardiol. 1982 May;49(7):1654-8 [7081053] Rev Physiol Biochem Pharmacol. 1983;97:1-67 [6306751] Biochem J. 1991 Jul 1;277 ( Pt 1):73-9 [1906712] Toxicology. 1992;71(1-2):173-9 [1729764] J Biol Chem. 1992 Jun 15;267(17):11789-93 [1376313] Trends Pharmacol Sci. 1992 Sep;13(9):359-65 [1382336] J Natl Cancer Inst. 1992 Dec 2;84(23):1811-6 [1359155] Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3438-42 [8159766] Brain Res. 1996 Feb 5;708(1-2):29-37 [8720856] N Engl J Med. 1998 Jan 1;338(1):35-45 [9414330] Mol Pharmacol. 1998 Oct;54(4):695-703 [9765513] Clin Microbiol Rev. 1999 Jan;12(1):147-79 [9880479] Int J Food Microbiol. 1999 Jun 1;48(3):211-9 [10443540] Assay Drug Dev Technol. 2004 Oct;2(5):497-506 [15671647] Pharmacol Rev. 2005 Dec;57(4):473-508 [16382104] Drugs. 2005;65 Suppl 2:1-10 [16398057] Contact Dermatitis. 2006 Jan;54(1):61-2 [16426298] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Pharmacogenomics. 2006 Sep;7(6):889-908 [16981848] Science. 2008 Feb 15;319(5865):906-7 [18276874] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2011.02.016 ER - TY - JOUR T1 - Post-treatment with amphetamine enhances reinnervation of the ipsilateral side cortex in stroke rats AN - 862784957; 14614124 AB - Amphetamine (AM) treatment has been shown to alter behavioral recovery after ischemia caused by embolism, permanent unilateral occlusion of the common carotid and middle cerebral arteries, or unilateral sensorimotor cortex ablation in rats. However, the behavioral results are inconsistent possibly due to difficulty controlling the size of the lesion before treatment. There is also evidence that AM promotes neuroregeneration in the cortex contralateral to the infarction; however, the effects of AM in the ipsilateral cortex remain unclear. The purpose of this study was to employ T2-weighted imaging (T2WI) to establish controlled criteria for AM treatment and to examine neuroregenerative effects in both cortices after stroke. Adult rats were anesthetized, and the right middle cerebral artery was ligated for 90 min to generate lesions in the ipsilateral cortex. Animals were separated into two equal treatment groups (AM or saline) according to the size of infarction, measured by T2WI at 2 days after stroke. AM or saline was administered to stroke rats every third day starting on day 3 for 4 weeks. AM treatment significantly reduced neurological deficits, as measured by body asymmetry and Bederson's score. T2WI and diffusion tensor imaging (DTI) were used to examine the size of infarction and axonal reinnervation, respectively, before and following treatment on days 2, 10 and 25 after stroke. AM treatment reduced the volume of tissue loss on days 10 and 25. A significant increase in fractional anisotropy ratio was found in the ipsilateral cortex after repeated AM administration, suggesting a possible increase in axonal outgrowth in the lesioned side cortex. Western analysis indicated that AM significantly increased the expression of synaptophysin ipsilaterally and neurofilament bilaterally. AM also enhanced matrix metalloproteinase (MMP) enzymatic activity, determined by MMP zymography in the lesioned side cortex. qRT-PCR was used to examine the expression of trophic factors after the 1st and 2nd doses of AM or saline injection. The expression of BDNF, but not BMP7 or CART, was significantly enhanced by AM in the lesioned side cortex. In conclusion, post-stroke treatment with AM facilitates behavioral recovery, which is associated with an increase in fractional anisotropy activity, enhanced fiber growth in tractography, synaptogenesis, upregulation of BDNF, and MMP activity mainly in the lesioned cortex. Our data suggest that the ipsilateral cortex may be the major target of action in stroke brain after AM treatment. JF - NeuroImage AU - Liu, Hua-Shan AU - Shen, Hui AU - Harvey, Brandon K AU - Castillo, Priscila AU - Lu, Hanbing AU - Yang, Yihong AU - Wang, Yun AD - Neural Protection and Regeneration Section, National Institute on Drug Abuse, Baltimore, MD, USA, ywang@intra.nida.nih.gov Y1 - 2011/05/01/ PY - 2011 DA - 2011 May 01 SP - 280 EP - 289 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 56 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Amphetamine KW - Cortex KW - W 30910:Imaging KW - N3:11001 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862784957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Post-treatment+with+amphetamine+enhances+reinnervation+of+the+ipsilateral+side+cortex+in+stroke+rats&rft.au=Liu%2C+Hua-Shan%3BShen%2C+Hui%3BHarvey%2C+Brandon+K%3BCastillo%2C+Priscila%3BLu%2C+Hanbing%3BYang%2C+Yihong%3BWang%2C+Yun&rft.aulast=Liu&rft.aufirst=Hua-Shan&rft.date=2011-05-01&rft.volume=56&rft.issue=1&rft.spage=280&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2011.02.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Cortex DO - http://dx.doi.org/10.1016/j.neuroimage.2011.02.049 ER - TY - JOUR T1 - A wavelet-based method for measuring the oscillatory dynamics of resting-state functional connectivity in MEG AN - 862783376; 14614147 AB - Determining the dynamics of functional connectivity is critical for understanding the brain. Recent functional magnetic resonance imaging (fMRI) studies demonstrate that measuring correlations between brain regions in resting-state activity can be used to reveal intrinsic neural networks. To study the oscillatory dynamics that underlie intrinsic functional connectivity between regions requires high temporal resolution measures of electrophysiological brain activity, such as magnetoencephalography (MEG). However, there is a lack of consensus as to the best method for examining connectivity in resting-state MEG data. Here we adapted a wavelet-based method for measuring phase-locking with respect to the frequency of neural oscillations. This method employs anatomical MRI information combined with MEG data using the minimum norm estimate inverse solution to produce functional connectivity maps from a "seed" region to all other locations on the cortical surface at any and all frequencies of interest. We test this method by simulating phase-locked oscillations at various points on the cortical surface, which illustrates a substantial artifact that results from imperfections in the inverse solution. We demonstrate that normalizing resting-state MEG data using phase-locking values computed on empty room data reduces much of the effects of this artifact. We then use this method with eight subjects to reveal intrinsic interhemispheric connectivity in the auditory network in the alpha frequency band in a silent environment. This spectral resting-state functional connectivity imaging method may allow us to better understand the oscillatory dynamics underlying intrinsic functional connectivity in the human brain. JF - NeuroImage AU - Ghuman, Avniel Singh AU - McDaniel, Jonathan R AU - Martin, Alex AD - Laboratory of Brain and Cognition, National Institute of Mental Health, USA, ghumana@mail.nih.gov Y1 - 2011/05/01/ PY - 2011 DA - 2011 May 01 SP - 69 EP - 77 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 56 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Resting-state KW - Magnetoencephalography KW - Functional connectivity KW - Phase-locking KW - Neural oscillations KW - Oscillatory dynamics KW - Brain mapping KW - Neuroimaging KW - Seeds KW - Data processing KW - Oscillations KW - Neural networks KW - Functional magnetic resonance imaging KW - Cerebral hemispheres KW - Frequency dependence KW - W 30960:Bioinformatics & Computer Applications KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862783376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=A+wavelet-based+method+for+measuring+the+oscillatory+dynamics+of+resting-state+functional+connectivity+in+MEG&rft.au=Ghuman%2C+Avniel+Singh%3BMcDaniel%2C+Jonathan+R%3BMartin%2C+Alex&rft.aulast=Ghuman&rft.aufirst=Avniel&rft.date=2011-05-01&rft.volume=56&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2011.01.046 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Brain mapping; Magnetoencephalography; Seeds; Neuroimaging; Data processing; Oscillations; Neural networks; Cerebral hemispheres; Functional magnetic resonance imaging; Frequency dependence DO - http://dx.doi.org/10.1016/j.neuroimage.2011.01.046 ER - TY - JOUR T1 - Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease. AN - 862602873; 20950656 AB - In this mini-review/opinion article we describe evidence that multiple cellular and molecular alterations in Alzheimer's disease (AD) pathogenesis involve perturbed cellular calcium regulation, and that alterations in synaptic calcium handling may be early and pivotal events in the disease process. With advancing age neurons encounter increased oxidative stress and impaired energy metabolism, which compromise the function of proteins that control membrane excitability and subcellular calcium dynamics. Altered proteolytic cleavage of the β-amyloid precursor protein (APP) in response to the aging process in combination with genetic and environmental factors results in the production and accumulation of neurotoxic forms of amyloid β-peptide (Aβ). Aβ undergoes a self-aggregation process and concomitantly generates reactive oxygen species that can trigger membrane-associated oxidative stress which, in turn, impairs the functions of ion-motive ATPases and glutamate and glucose transporters thereby rendering neurons vulnerable to excitotoxicity and apoptosis. Mutations in presenilin-1 that cause early-onset AD increase Aβ production, but also result in an abnormal increase in the size of endoplasmic reticulum calcium stores. Some of the events in the neurodegenerative cascade can be counteracted in animal models by manipulations that stabilize neuronal calcium homeostasis including dietary energy restriction, agonists of glucagon-like peptide 1 receptors and drugs that activate mitochondrial potassium channels. Emerging knowledge of the actions of calcium upstream and downstream of Aβ provides opportunities to develop novel preventative and therapeutic interventions for AD. This article is part of a Special Issue entitled: 11th European Symposium on Calcium. Published by Elsevier B.V. JF - Biochimica et biophysica acta AU - Camandola, Simonetta AU - Mattson, Mark P AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA. Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 965 EP - 973 VL - 1813 IS - 5 SN - 0006-3002, 0006-3002 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Humans KW - Subcellular Fractions -- metabolism KW - Calcium Signaling KW - Calcium -- metabolism KW - Aging -- metabolism KW - Alzheimer Disease -- genetics KW - Neurons -- metabolism KW - Aging -- pathology KW - Alzheimer Disease -- metabolism KW - Neurons -- pathology KW - Alzheimer Disease -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862602873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Aberrant+subcellular+neuronal+calcium+regulation+in+aging+and+Alzheimer%27s+disease.&rft.au=Camandola%2C+Simonetta%3BMattson%2C+Mark+P&rft.aulast=Camandola&rft.aufirst=Simonetta&rft.date=2011-05-01&rft.volume=1813&rft.issue=5&rft.spage=965&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbamcr.2010.10.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-18 N1 - Date created - 2011-04-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell Calcium. 2000 Nov-Dec;28(5-6):329-38 [11115372] Brain Res. 2002 Jan 11;924(2):133-40 [11750898] Trends Neurosci. 2001 Nov;24(11 Suppl):S2-6 [11881741] Nature. 2002 Apr 4;416(6880):535-9 [11932745] J Biol Chem. 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AN - 862601831; 21495870 AB - Tumor progression is the continual selection of variant subpopulations of malignant cells that have acquired increasing levels of genetic instability (Nowell Science 1976, 194, 23-28). This instability is manifested as chromosomal aneuploidy or translocations, viral integration or somatic mutations that typically affect the expression of a gene (oncogene) that is especially damaging to the proper function of a cell. With the recent discovery of non-coding RNAs such as microRNAs (miRNAs), the concept that a target of genetic instability must be a protein-encoding gene is no longer tenable. Over the years, we have conducted several studies comparing the location of miRNA genes to positions of genetic instability, principally retroviral integration sites and chromosomal translocations in the mouse as a means of identifying miRNAs of importance in carcinogenesis. In this current study, we have used the most recent annotation of the mouse miRome (miRBase, release 16.0), and several datasets reporting the sites of integration of different retroviral vectors in a variety of mouse strains and mouse models of cancer, including for the first time a model that shows a propensity to form solid tumors, as a means to further identify or define, candidate oncogenic miRNAs. Several miRNA genes and miRNA gene clusters stand out as interesting new candidate oncogenes due to their close proximity to common retroviral integration sites including miR-29a/b/c and miR106a~363. We also discussed some recently identified miRNAs including miR-1965, miR-1900, miR-1945, miR-1931, miR-1894, and miR-1936 that are close to common retroviral integration sites and are therefore likely to have some role in cell homeostasis. JF - Toxicology mechanisms and methods AU - Huppi, Konrad AU - Pitt, Jason AU - Wahlberg, Brady AU - Caplen, Natasha J AD - Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. huppi@helix.nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 325 EP - 333 VL - 21 IS - 4 KW - MicroRNAs KW - 0 KW - Index Medicus KW - Gene Expression Profiling KW - Animals KW - Mice KW - Retroviridae -- genetics KW - Mutagenesis KW - Genomic Instability KW - MicroRNAs -- genetics KW - Neoplasms, Experimental -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862601831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+mechanisms+and+methods&rft.atitle=Genomic+instability+and+mouse+microRNAs.&rft.au=Huppi%2C+Konrad%3BPitt%2C+Jason%3BWahlberg%2C+Brady%3BCaplen%2C+Natasha+J&rft.aulast=Huppi&rft.aufirst=Konrad&rft.date=2011-05-01&rft.volume=21&rft.issue=4&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Toxicology+mechanisms+and+methods&rft.issn=1537-6524&rft_id=info:doi/10.3109%2F15376516.2011.562759 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-22 N1 - Date created - 2011-04-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Cell. 2002 Oct;2(4):253-5 [12398888] Oncotarget. 2010 Sep;1(5):349-58 [20948989] Science. 1976 Oct 1;194(4260):23-8 [959840] Proc Natl Acad Sci U S A. 1990 Sep;87(18):6964-8 [2402486] Nature. 2005 Jun 9;435(7043):828-33 [15944707] FEBS Lett. 2005 Oct 31;579(26):5904-10 [16214134] EMBO J. 2006 Jul 26;25(14):3422-31 [16858412] Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18680-4 [17121985] Semin Cancer Biol. 2007 Feb;17(1):65-73 [17113784] Cancer Res. 2007 Jun 15;67(12):5699-707 [17575136] BMC Genomics. 2007;8:166 [17565689] Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15805-10 [17890317] J Biol Chem. 2007 Nov 16;282(46):33632-40 [17848567] Nat Rev Genet. 2008 Mar;9(3):204-17 [18227811] Retrovirology. 2008;5:4 [18194563] Mol Cancer Res. 2008 Feb;6(2):212-21 [18314482] Cell. 2008 May 16;133(4):727-41 [18485879] Cancer Res. 2008 Oct 1;68(19):8164-72 [18829576] Cell Cycle. 2008 Oct;7(20):3112-8 [18927505] Genome Res. 2008 Nov;18(11):1787-97 [18849523] Mol Syst Biol. 2008;4:229 [19034270] Annu Rev Pathol. 2009;4:199-227 [18817506] Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12085-90 [19597153] EMBO J. 2009 Sep 16;28(18):2719-32 [19696742] Genes Dev. 2009 Oct 15;23(20):2388-93 [19833767] Mol Cell. 2009 Nov 25;36(4):631-41 [19941823] Genes Dev. 2009 Dec 15;23(24):2806-11 [20008931] Lab Invest. 2010 Feb;90(2):144-55 [20048743] J Exp Med. 2010 Mar 15;207(3):475-89 [20212066] Genome Res. 2010 May;20(5):589-99 [20439436] Science. 2010 Nov 19;330(6007):1104-7 [20947725] Immunol Rev. 2003 Aug;194:177-95 [12846815] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/15376516.2011.562759 ER - TY - JOUR T1 - Update on targeted therapies for clear cell renal cell carcinoma. AN - 862280347; 21330923 AB - The article reviews the evolution of targeted therapies for clear cell renal cell carcinoma (RCC) and recent developments in the field. The vast majority of work in kidney cancer deals with clear cell RCC, which is the most common variant of this malignancy. The identification of loss of function of the von Hippel-Lindau protein as the basis for clear cell RCC, in addition to the well designed clinical trials that have ensued, provide an outstanding model for the development of mechanism-based targeted therapy in cancer. The treatment of advanced and metastatic RCC continues to be a major challenge for uro-oncologists despite the approval of six targeted therapies over the past 5 years. This rapid growth in therapeutic options has brought much needed improvements in overall and progression-free survival, although durable complete responses are rare. However, the plurality of treatments also poses challenges in terms of selecting the best therapy for a given patient, designing trials with appropriate comparison arms and endpoints, identifying well tolerated and effective drug combinations or sequences, and determining the role of targeted therapies in the neoadjuvant and adjuvant settings. Vascular endothelial growth factor and mammalian target of rapamycin-targeted therapies continue to play a critical role in the management of advanced and metastatic RCC. Ongoing research to identify novel agents continues to build upon the work done during the elucidation of the von Hippel-Lindau/clear cell RCC pathway. It is hoped that ongoing and planned studies will enable development of therapeutic regimens that will incorporate agents with improved toxicity and better efficacy as well as defining a role for a multidisciplinary approach to the management of advanced RCC. JF - Current opinion in oncology AU - Singer, Eric A AU - Gupta, Gopal N AU - Srinivasan, Ramaprasad AD - Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 283 EP - 289 VL - 23 IS - 3 KW - Index Medicus KW - Humans KW - Neoadjuvant Therapy KW - Quality of Life KW - Chemotherapy, Adjuvant KW - Kidney Neoplasms -- genetics KW - Kidney Neoplasms -- therapy KW - Carcinoma, Renal Cell -- therapy KW - Carcinoma, Renal Cell -- secondary KW - Carcinoma, Renal Cell -- genetics KW - Kidney Neoplasms -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862280347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+oncology&rft.atitle=Update+on+targeted+therapies+for+clear+cell+renal+cell+carcinoma.&rft.au=Singer%2C+Eric+A%3BGupta%2C+Gopal+N%3BSrinivasan%2C+Ramaprasad&rft.aulast=Singer&rft.aufirst=Eric&rft.date=2011-05-01&rft.volume=23&rft.issue=3&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+oncology&rft.issn=1531-703X&rft_id=info:doi/10.1097%2FCCO.0b013e32834479c0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-09 N1 - Date created - 2011-04-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Clin Oncol. 2002 Jan 1;20(1):289-96 [11773181] Urol Oncol. 2011 May-Jun;29(3):237-43 [19914100] Nat Rev Cancer. 2003 Oct;3(10):721-32 [13130303] J Urol. 2003 Dec;170(6 Pt 1):2163-72 [14634372] Scand J Urol Nephrol. 1987;21(4):285-9 [3445125] J Urol. 1994 Nov;152(5 Pt 1):1626-31 [7523715] JAMA. 1999 May 5;281(17):1628-31 [10235157] J Clin Oncol. 2005 Jun 10;23(17):3923-31 [15897550] Cancer Cell. 2005 Sep;8(3):179-83 [16169463] J Support Oncol. 2006 Apr;4(4):191-9 [16669463] Cancer Res. 2006 Sep 1;66(17):8814-21 [16951198] J Natl Cancer Inst. 2006 Sep 20;98(18):1331-4 [16985252] N Engl J Med. 2007 Jan 11;356(2):115-24 [17215529] N Engl J Med. 2007 Jan 11;356(2):125-34 [17215530] N Engl J Med. 2007 May 31;356(22):2271-81 [17538086] Value Health. 2007 Jul-Aug;10(4):285-93 [17645683] Lancet Oncol. 2007 Nov;8(11):975-84 [17959415] J Clin Oncol. 2008 Apr 20;26(12):2034-9 [18347008] Cancer Immunol Immunother. 2008 Oct;57(10):1439-49 [18286285] BJU Int. 2008 Sep;102(6):692-6 [18410444] J Biol Chem. 2008 Dec 12;283(50):34495-9 [18945681] J Urol. 2009 Feb;181(2):518-23; discussion 523 [19100579] Urology. 2009 Feb;73(2):337-41 [18950837] Curr Opin Oncol. 2009 May;21(3):266-71 [19339887] Cancer Lett. 2009 Aug 8;280(2):145-53 [19111391] Cancer Res. 2009 Jun 1;69(11):4674-81 [19470766] J Clin Oncol. 2009 Jul 1;27(19):3225-34 [19470934] J Urol. 2009 Sep;182(3):881-6 [19616232] J Clin Oncol. 2009 Sep 1;27(25):4076-81 [19636008] J Clin Oncol. 2009 Sep 20;27(27):4462-8 [19652060] J Clin Oncol. 2009 Dec 1;27(34):5794-9 [19826129] J Clin Oncol. 2010 Feb 20;28(6):1061-8 [20100962] J Clin Oncol. 2010 May 1;28(13):2144-50 [20368553] J Clin Oncol. 2010 May 1;28(13):2137-43 [20368558] J Clin Oncol. 2010 May 1;28(13):2131-6 [20368560] Urol Int. 2010;84(4):479-84 [20299776] Clin Cancer Res. 2010 Jul 15;16(14):3628-38 [20606035] Target Oncol. 2010 Jun;5(2):131-8 [20632214] Target Oncol. 2010 Jun;5(2):119-29 [20680492] CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300 [20610543] Cancer. 2010 Sep 15;116(18):4256-65 [20549832] Eur Urol. 2009 Dec;56(6):959-71 [19748725] J Clin Oncol. 2010 Dec 1;28(34):5017-9 [20975069] J Clin Oncol. 2003 Apr 1;21(7):1214-22 [12663707] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1097/CCO.0b013e32834479c0 ER - TY - JOUR T1 - Redox active copper chelate overcomes multidrug resistance in T-lymphoblastic leukemia cell by triggering apoptosis. AN - 861787395; 21409205 AB - Multidrug resistance (MDR) mediated by the over expression of drug efflux protein P-glycoprotein (P-gp) is one of the major impediments to successful treatment of cancer. P-gp acts as an energy-dependent drug efflux pump and reduces the intracellular concentration of structurally unrelated drugs inside the cells. Therefore, there is an urgent need for development of new molecules that are less toxic to normal cell and preferentially effective against drug resistant malignant cells. In this preclinical study we report the apoptotic potential of copper N-(2-hydroxyacetophenone) glycinate (CuNG) on doxorubicin resistant T lymphoblastic leukaemia cells (CEM/ADR5000). To evaluate the cytotoxic effect of CuNG, we used different normal cell lines (NIH 3T3, Chang liver and human PBMC) and cancerous cell lines (CEM/ADR5000, parental sensitive CCRF-CEM, SiHa and 3LL) and conclude that CuNG preferentially kills cancerous cells, especially both leukemic cell types irrespective of their MDR status, while leaving normal cell totally unaffected. Moreover, CuNG involves reactive oxygen species (ROS) for induction of apoptosis in CEM/ADR5000 cells through the intrinsic apoptotic pathway. This is substantiated by our observation that antioxidant N-acetyle-cysteine (NAC) and PEG catalase could completely block ROS generation and, subsequently, abrogates CuNG induced apoptosis. On the other hand, uncomplexed ligand N-(2-hydroxyacetophenone) glycinate (NG) fails to generate a significant amount of ROS and concomitant induction of apoptosis in CEM/ADR5000 cells. Therefore, CuNG induces drug resistant leukemia cells to undergo apoptosis and proves to be a molecule having therapeutic potential to overcome MDR in cancer. JF - Molecular bioSystems AU - Ganguly, Avishek AU - Basu, Soumya AU - Banerjee, Kaushik AU - Chakraborty, Paramita AU - Sarkar, Avijit AU - Chatterjee, Mitali AU - Chaudhuri, Soumitra Kumar AD - Department of In vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, 37 SP Mukherjee Road, Calcutta 700 026, India. Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 1701 EP - 1712 VL - 7 IS - 5 KW - Antibiotics, Antineoplastic KW - 0 KW - Organometallic Compounds KW - Reactive Oxygen Species KW - copper (N-2-hydroxyacetophenone)glycinate KW - Copper KW - 789U1901C5 KW - Doxorubicin KW - 80168379AG KW - Cytochromes c KW - 9007-43-6 KW - Glutathione KW - GAN16C9B8O KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Cytochromes c -- metabolism KW - Oxidation-Reduction -- drug effects KW - Dose-Response Relationship, Drug KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- pathology KW - Humans KW - Glutathione -- metabolism KW - Mice KW - Cell Line, Tumor KW - NIH 3T3 Cells KW - Copper -- chemistry KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- metabolism KW - Blotting, Western KW - Cell Survival -- drug effects KW - Doxorubicin -- pharmacology KW - Antibiotics, Antineoplastic -- pharmacology KW - Cells, Cultured KW - Flow Cytometry KW - Time Factors KW - Cell Cycle -- drug effects KW - Cell Line KW - Organometallic Compounds -- pharmacology KW - Glycine -- pharmacology KW - Apoptosis -- drug effects KW - Drug Resistance, Multiple -- drug effects KW - Glycine -- analogs & derivatives KW - Organometallic Compounds -- chemistry KW - Drug Resistance, Neoplasm -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/861787395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+bioSystems&rft.atitle=Redox+active+copper+chelate+overcomes+multidrug+resistance+in+T-lymphoblastic+leukemia+cell+by+triggering+apoptosis.&rft.au=Ganguly%2C+Avishek%3BBasu%2C+Soumya%3BBanerjee%2C+Kaushik%3BChakraborty%2C+Paramita%3BSarkar%2C+Avijit%3BChatterjee%2C+Mitali%3BChaudhuri%2C+Soumitra+Kumar&rft.aulast=Ganguly&rft.aufirst=Avishek&rft.date=2011-05-01&rft.volume=7&rft.issue=5&rft.spage=1701&rft.isbn=&rft.btitle=&rft.title=Molecular+bioSystems&rft.issn=1742-2051&rft_id=info:doi/10.1039%2Fc0mb00306a LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-30 N1 - Date created - 2011-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1039/c0mb00306a ER - TY - JOUR T1 - Socio-demographic correlates of subjective well-being in urban India AN - 861588789; 4186215 AB - This study aimed to explore subjective well-being (SWB) in an urban Indian sample. Adults (n=1099) belonging to two wards in the city of Bangalore in South India, responded to a study-specific questionnaire. This paper is based on data generated as part of an ongoing larger study looking at correlates of SWB. Almost equal number of men and women responded to the study and their age ranged from 20 to 81years (mean age 37 years). Majority of them were married, Hindus, from middle socio-economic status, had studied above pre-university level and more than half were earning. The mean scores on positive affect (40.9), negative affect (27.6) and life satisfaction (24) suggested above average levels of SWB. Higher age, being married, having higher education, higher income and working in a full time job seemed to improve life satisfaction and decrease negative affect. Religion was also significantly associated with negative affect. Step-wise regression analysis suggested that only education and income were important predictors of positive affect, while negative affect was better predicted by age, income, work status and religion. Life satisfaction was predicted by income, age and education. The important correlates of SWB for men and women were somewhat different. Overall, sociodemographic variables have minimal effect on SWB in urban India and research needs to explore other predictors of SWB. Reprinted by permission of Springer JF - Social indicators research AU - Agrawal, Jyotsna AU - Murthy, Pratima AU - Philip, Mariamma AU - Mehrotra, Seema AU - Thennarasu, K AU - John, John P AU - Girish, N AU - Thippeswamy, V AU - Isaac, Mohan AD - National Institute of Mental Health and Neurosciences, India ; University of Western Australia Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 419 EP - 434 VL - 101 IS - 3 SN - 0303-8300, 0303-8300 KW - Anthropology KW - Demography KW - Emotions KW - Education KW - Regression analysis KW - Well-being KW - Life satisfaction KW - India KW - Income KW - Urban areas UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/861588789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+indicators+research&rft.atitle=Socio-demographic+correlates+of+subjective+well-being+in+urban+India&rft.au=Agrawal%2C+Jyotsna%3BMurthy%2C+Pratima%3BPhilip%2C+Mariamma%3BMehrotra%2C+Seema%3BThennarasu%2C+K%3BJohn%2C+John+P%3BGirish%2C+N%3BThippeswamy%2C+V%3BIsaac%2C+Mohan&rft.aulast=Agrawal&rft.aufirst=Jyotsna&rft.date=2011-05-01&rft.volume=101&rft.issue=3&rft.spage=419&rft.isbn=&rft.btitle=&rft.title=Social+indicators+research&rft.issn=03038300&rft_id=info:doi/10.1007%2Fs11205-010-9669-5 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 7400 11272; 13530 13521; 4196; 3412; 13161 1247; 10739 12228 10919; 6271; 4049; 175 387 30 DO - http://dx.doi.org/10.1007/s11205-010-9669-5 ER - TY - JOUR T1 - Divergent effects of oxidatively induced modification to the C8 of 2'-deoxyadenosine on transcription factor binding: 8,5'(S)-cyclo-2'-deoxyadenosine inhibits the binding of multiple sequence specific transcription factors, while 8-oxo-2'-deoxyadenosine increases binding of CREB and NF-kappa B to DNA. AN - 861204899; 20872830 AB - DNA is exposed to endogenous and environmental factors that can form stable lesions. If not repaired, these lesions can lead to transcription/replication blocking or mutagenic bypass. Our previous work has focused on 8,5'-cyclopurine 2'-deoxyribonucleosides, a unique class of oxidatively induced DNA lesions that are specifically repaired by the NER pathway (see Brooks PJ [2008]: DNA Repair 7:1168-1179). Here we used EMSA to monitor the ability of sequence-specific transcription factors, HSF1, CREB, and NF-kappaB and "architectural" transcription factor, HMGA, to bind to their target sequences when 8, 5'(S)-cyclo-2'-deoxyadenosine (cyclo-dAdo) is present within their recognition sequences. For comparison, we also tested the effect of 8-oxo-7,8-dihydro-2'-deoxyadenosine (8-oxo-dAdo) in the same recognition sequences. The presence of a cyclo-dAdo lesion in the target sequence essentially eliminated the binding activity of HSF1, CREB, and NF-kappa B whereas HMGA retained some of its binding activity. In contrast, 8-oxo-dAdo had no obvious effect on the binding activity of HSF1 and HMGA in comparison to lesion-free DNA. Notably, though, CREB and NFκB binding increased when an 8-oxo-dAdo lesion was present in their target sequence. Competition EMSA showed about 2-3-fold increased affinity of both proteins for the 8-oxo-dAdo containing target sequence compared to lesion-free DNA. Molecular modeling of the lesions in the NF-kappaB sequence indicated that 8-oxo-dAdo may form an additional hydrogen bond with the protein, thereby strengthening the binding of NF-kappa B to its DNA target. The cyclo-dAdo lesion, in contrast, distorted the DNA structure, providing an explanation for the inhibition of NF-kappaB binding. Published 2010 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Abraham, Jessy AU - Brooks, Philip J AD - Section on Molecular Neurobiology, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20852, USA. Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 287 EP - 295 VL - 52 IS - 4 KW - Cyclic AMP Response Element-Binding Protein KW - 0 KW - DNA-Binding Proteins KW - Deoxyadenosines KW - HMGA Proteins KW - Hsf1 protein, mouse KW - NF-kappa B KW - Transcription Factors KW - 8,5'-cyclo-2'-deoxyadenosine KW - 117182-88-4 KW - 2'-deoxy-7,8-dihydro-8-oxoadenosine KW - 62471-63-0 KW - DNA KW - 9007-49-2 KW - 2'-deoxyadenosine KW - P582C98ULC KW - Index Medicus KW - Animals KW - DNA-Binding Proteins -- chemistry KW - Humans KW - Transcription Factors -- chemistry KW - HMGA Proteins -- chemistry KW - Mice KW - Protein Binding KW - Cell Line KW - NF-kappa B -- chemistry KW - Oxidative Stress KW - DNA -- chemistry KW - Deoxyadenosines -- chemistry KW - Cyclic AMP Response Element-Binding Protein -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/861204899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Divergent+effects+of+oxidatively+induced+modification+to+the+C8+of+2%27-deoxyadenosine+on+transcription+factor+binding%3A+8%2C5%27%28S%29-cyclo-2%27-deoxyadenosine+inhibits+the+binding+of+multiple+sequence+specific+transcription+factors%2C+while+8-oxo-2%27-deoxyadenosine+increases+binding+of+CREB+and+NF-kappa+B+to+DNA.&rft.au=Abraham%2C+Jessy%3BBrooks%2C+Philip+J&rft.aulast=Abraham&rft.aufirst=Jessy&rft.date=2011-05-01&rft.volume=52&rft.issue=4&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20619 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-22 N1 - Date created - 2011-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20619 ER - TY - JOUR T1 - Phase I trial of vandetanib and bevacizumab evaluating the VEGF and EGF signal transduction pathways in adults with solid tumours and lymphomas. AN - 860398349; 21247755 AB - Inhibition of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) pathways may result in synergistic antitumour activity. We designed a phase I study to evaluate the combination of vandetanib, an investigational agent with activity against EGF receptor and VEGF receptor 2, and bevacizumab, a monoclonal antibody against VEGF. Patients with advanced solid tumours and lymphomas were enrolled. Objectives were to determine the safety and maximum tolerated dose of the combination, characterise pharmacokinetics, measure angiogenic marker changes in blood, and assess tumour blood flow using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Vandetanib was given orally once daily and bevacizumab intravenously once in every 3 weeks in 21-day cycles utilising a standard dose-escalation design. Fifteen patients were enrolled, and a total of 94 cycles of therapy were administered. No protocol-defined dose-limiting toxicities were observed; due to toxicities associated with chronic dosing, hypertension, proteinuria, diarrhoea and anorexia, dose escalation was stopped at the second dose level. We observed one partial response and one minor response; 9 patients experienced stable disease. There were significant changes in plasma VEGF and placental-derived growth factor levels, and decreases in K(trans) and k(ep) were observed by DCE-MRI. In this trial, we safely combined two targeted agents that cause dual blockade of the VEGF pathway, demonstrated preliminary evidence of clinical activity, and conducted correlative studies demonstrating anti-angiogenic effect. The recommended phase II dose was established as vandetanib 200 mg daily and bevacizumab 7.5 mg/kg every 3 weeks. Published by Elsevier Ltd. JF - European journal of cancer (Oxford, England : 1990) AU - Kummar, Shivaani AU - Gutierrez, Martin E AU - Chen, Alice AU - Turkbey, Ismail B AU - Allen, Deborah AU - Horneffer, Yvonne R AU - Juwara, Lamin AU - Cao, Liang AU - Yu, Yunkai AU - Kim, Yeong Sang AU - Trepel, Jane AU - Chen, Helen AU - Choyke, Peter AU - Melillo, Giovanni AU - Murgo, Anthony J AU - Collins, Jerry AU - Doroshow, James H AD - Center for Cancer Research, National Cancer Institute, 10 Center Drive, Bethesda, MD 20892, USA. kummars@mail.nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 997 EP - 1005 VL - 47 IS - 7 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Antineoplastic Agents KW - Biomarkers, Tumor KW - Contrast Media KW - Piperidines KW - Quinazolines KW - Vascular Endothelial Growth Factor A KW - Bevacizumab KW - 2S9ZZM9Q9V KW - Epidermal Growth Factor KW - 62229-50-9 KW - Vascular Endothelial Growth Factor Receptor-2 KW - EC 2.7.10.1 KW - N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine KW - YO460OQ37K KW - Index Medicus KW - Humans KW - Aged KW - Magnetic Resonance Imaging -- methods KW - Adult KW - Middle Aged KW - Contrast Media -- pharmacology KW - Vascular Endothelial Growth Factor Receptor-2 -- metabolism KW - Time Factors KW - Antineoplastic Agents -- pharmacology KW - Signal Transduction KW - Female KW - Male KW - Epidermal Growth Factor -- antagonists & inhibitors KW - Neoplasms -- drug therapy KW - Antibodies, Monoclonal -- therapeutic use KW - Piperidines -- pharmacology KW - Vascular Endothelial Growth Factor A -- antagonists & inhibitors KW - Piperidines -- therapeutic use KW - Quinazolines -- therapeutic use KW - Lymphoma -- drug therapy KW - Lymphoma -- metabolism KW - Epidermal Growth Factor -- metabolism KW - Quinazolines -- pharmacology KW - Vascular Endothelial Growth Factor A -- metabolism KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860398349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+%28Oxford%2C+England+%3A+1990%29&rft.atitle=Phase+I+trial+of+vandetanib+and+bevacizumab+evaluating+the+VEGF+and+EGF+signal+transduction+pathways+in+adults+with+solid+tumours+and+lymphomas.&rft.au=Kummar%2C+Shivaani%3BGutierrez%2C+Martin+E%3BChen%2C+Alice%3BTurkbey%2C+Ismail+B%3BAllen%2C+Deborah%3BHorneffer%2C+Yvonne+R%3BJuwara%2C+Lamin%3BCao%2C+Liang%3BYu%2C+Yunkai%3BKim%2C+Yeong+Sang%3BTrepel%2C+Jane%3BChen%2C+Helen%3BChoyke%2C+Peter%3BMelillo%2C+Giovanni%3BMurgo%2C+Anthony+J%3BCollins%2C+Jerry%3BDoroshow%2C+James+H&rft.aulast=Kummar&rft.aufirst=Shivaani&rft.date=2011-05-01&rft.volume=47&rft.issue=7&rft.spage=997&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+%28Oxford%2C+England+%3A+1990%29&rft.issn=1879-0852&rft_id=info:doi/10.1016%2Fj.ejca.2010.12.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-15 N1 - Date created - 2011-04-05 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Oncologist. 2009 Apr;14(4):399-411 [19357226] J Clin Oncol. 2009 Mar 20;27(9):1432-9 [19224847] Cancer Res. 2004 Aug 1;64(15):5355-62 [15289342] Clin Cancer Res. 2004 Oct 1;10(19):6487-501 [15475436] Pharmacol Rev. 1951 Mar;3(1):1-41 [14833874] Nat Med. 2005 Mar;11(3):261-2 [15723071] Clin Cancer Res. 2005 May 1;11(9):3514-22 [15867254] Ann Oncol. 2005 Aug;16(8):1391-7 [15905307] J Clin Oncol. 2005 Nov 1;23(31):8136-9 [16258121] Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2197-207 [16609035] Curr Med Chem. 2006;13(16):1845-57 [16842197] J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] Cancer Res. 2001 Jun 1;61(11):4341-4 [11389057] Cancer Res. 2002 Aug 15;62(16):4645-55 [12183421] Cancer Res. 2002 Dec 15;62(24):7284-90 [12499271] Clin Cancer Res. 2003 Jan;9(1):377-82 [12538491] Clin Cancer Res. 2003 Apr;9(4):1546-56 [12684431] Cancer Res. 2003 Dec 1;63(23):8345-50 [14678995] Am J Kidney Dis. 2007 Feb;49(2):186-93 [17261421] J Thorac Oncol. 2006 Nov;1(9):1002-9 [17409986] J Clin Oncol. 2007 Oct 10;25(29):4557-61 [17876013] N Engl J Med. 2008 Mar 13;358(11):1129-36 [18337603] N Engl J Med. 2009 Feb 5;360(6):563-72 [19196673] J Clin Oncol. 2009 Feb 10;27(5):672-80 [19114685] Angiogenesis. 2009;12(2):159-64 [19221886] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ejca.2010.12.016 ER - TY - JOUR T1 - Prospective study of serum cysteine levels and oesophageal and gastric cancers in China. AN - 860396224; 21242262 AB - Cancers of the upper gastrointestinal tract remain a significant cause of morbidity and mortality. Cysteine, known to be involved in a myriad of immuno-modulatory, anti-oxidant, and anti-carcinogenic pathways, has not been investigated in the aetiology of oesophageal or gastric cancers. To examine the relationship between serum cysteine concentration and risk of these cancers we conducted a nested case-cohort study within the General Population Nutrition Intervention Trial in Linxian, China. 498 oesophageal squamous cell carcinomas (OSCCs) and 255 gastric cardia adenocarcinomas (GCAs) were matched by age and sex to 947 individuals from the wider cohort. We calculated HRs and 95% CIs using the case-cohort estimator for the Cox proportional hazards models, stratified on age and sex, with adjustment for potential confounders. Higher concentrations of serum cysteine were significantly associated with a lower risk of both OSCC and GCA. For those in the highest quartile of serum cysteine, compared to those in the lowest, the multivariate HRs were 0.70 for OSCC (95% CI 0.51 to 0.98) and 0.59 for GCA (95% CI 0.38 to 0.91). These associations were dose dependent (p for trend=0.006 and 0.008, respectively). These inverse associations were not significantly modified by other risk factors, with the exception of age, where a stronger association was noted among persons in the older age strata. Higher serum concentrations of cysteine were associated with a significantly reduced risk of OSCC and GCA. Cysteine should be further investigated for its potential as a chemopreventive agent for upper gastrointestinal cancers. JF - Gut AU - Murphy, Gwen AU - Fan, Jin-Hu AU - Mark, Steven D AU - Dawsey, Sanford M AU - Selhub, Jacob AU - Wang, Jianbing AU - Taylor, Philip R AU - Qiao, You-Lin AU - Abnet, Christian C AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. murphygw@mail.nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 618 EP - 623 VL - 60 IS - 5 KW - Biomarkers, Tumor KW - 0 KW - Cysteine KW - K848JZ4886 KW - Abridged Index Medicus KW - Index Medicus KW - Age Factors KW - Epidemiologic Methods KW - Humans KW - Alcohol Drinking -- adverse effects KW - Smoking -- adverse effects KW - Aged KW - Alcohol Drinking -- blood KW - Smoking -- blood KW - Prospective Studies KW - Adult KW - Cardia KW - Middle Aged KW - Female KW - Male KW - Carcinoma, Squamous Cell -- etiology KW - Adenocarcinoma -- blood KW - Adenocarcinoma -- etiology KW - Stomach Neoplasms -- blood KW - Cysteine -- blood KW - Esophageal Neoplasms -- blood KW - Carcinoma, Squamous Cell -- blood KW - Stomach Neoplasms -- etiology KW - Esophageal Neoplasms -- etiology KW - Biomarkers, Tumor -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860396224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gut&rft.atitle=Prospective+study+of+serum+cysteine+levels+and+oesophageal+and+gastric+cancers+in+China.&rft.au=Murphy%2C+Gwen%3BFan%2C+Jin-Hu%3BMark%2C+Steven+D%3BDawsey%2C+Sanford+M%3BSelhub%2C+Jacob%3BWang%2C+Jianbing%3BTaylor%2C+Philip+R%3BQiao%2C+You-Lin%3BAbnet%2C+Christian+C&rft.aulast=Murphy&rft.aufirst=Gwen&rft.date=2011-05-01&rft.volume=60&rft.issue=5&rft.spage=618&rft.isbn=&rft.btitle=&rft.title=Gut&rft.issn=1468-3288&rft_id=info:doi/10.1136%2Fgut.2010.225854 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-22 N1 - Date created - 2011-04-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Int J Cancer. 2005 Jan 20;113(3):456-63 [15455378] Eur J Gastroenterol Hepatol. 2007 Sep;19(9):769-74 [17700262] Int J Cancer. 2009 Mar 15;124(6):1270-5 [19058177] Cancer Prev Res (Phila). 2010 Jan;3(1):62-72 [20051373] Cancer Res. 2010 Mar 15;70(6):2397-405 [20197471] J Nutr. 2000 Feb;130(2):129-32 [10720158] J Natl Cancer Inst. 2000 Jun 21;92(12):977-86 [10861309] Cancer. 2000 Jul 15;89(2):376-82 [10918169] Cancer Res. 2001 Mar 15;61(6):2472-9 [11289117] J Hepatol. 2001 Jun;34(6):946-54 [11451183] Lifetime Data Anal. 2001 Dec;7(4):331-44 [11763542] Int J Cancer. 2002 Apr 1;98(4):493-7 [11920607] Int J Vitam Nutr Res. 2002 Dec;72(6):375-82 [12596503] Biomed Pharmacother. 2003 May-Jun;57(3-4):145-55 [12818476] Cancer Epidemiol Biomarkers Prev. 2003 Nov;12(11 Pt 1):1188-93 [14652279] J Nutr. 2004 Mar;134(3):489-92 [14988435] Natl Cancer Inst Monogr. 1985 Dec;69:29-34 [3914622] J Chromatogr. 1987 Nov 27;422:43-52 [3437026] Am J Med. 1991 Sep 30;91(3C):140S-144S [1928206] Ann Epidemiol. 1993 Nov;3(6):577-85 [7921303] Int J Epidemiol. 1994 Jun;23(3):444-50 [7960367] Am J Clin Nutr. 1996 Feb;63(2):242-8 [8561066] Int J Cancer. 1997 Jul 3;72(1):95-101 [9212229] AIDS. 1998 Jul 9;12(10):1245 [9677175] J Natl Cancer Inst. 1993 Sep 15;85(18):1483-92 [8360931] Am J Physiol. 1998 Oct;275(4 Pt 1):G749-57 [9756506] Cancer Epidemiol Biomarkers Prev. 2006 Jan;15(1):146-9 [16434601] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/gut.2010.225854 ER - TY - JOUR T1 - Quantifying muscle asymmetries in cervical dystonia with electrical impedance: a preliminary assessment. AN - 859052991; 20943436 AB - Cervical dystonia (CD) lacks an objective quantitative measure. Electrical impedance myography (EIM) is a non-invasive assessment method sensitive to changes in muscle structure and physiology. We evaluate the potential role of EIM in quantifying CD, hypothesizing that patients would demonstrate differences in the symmetry of muscle electrical resistance compared to controls, and that this asymmetry would decrease after botulinum neurotoxin (BoNT) treatment. EIM was performed on the sternocleidomastoid (SCM) and cervical paraspinal (PS) muscles of CD patients and age-matched controls. 50 kHz resistance was analyzed, comparing side-to-side asymmetry in patients and controls, and, in patients, before and after BoNT treatment. Sixteen patients and 10 controls were included. Resistance asymmetry was on average 3-5 times higher in patients than controls. Receiver operating characteristic analysis demonstrated 91% accuracy of discriminating CD from normal. From pre-treatment to maximum BoNT effect, asymmetry decreased from 20.8(13.9-26.1)% to 6.2(3.1-9.9)% (SCM), and from 16.0(14.3-16.0)% to 8.4(7.0-9.2)% (PS), p<0.05 (median, interquartile range). EIM effectively differentiates normal subjects from CD patients by revealing asymmetries in resistance values and detects improvement in muscle symmetry after treatment. These results suggest that EIM, a painless, non-invasive measure, can provide a useful quantitative metric in CD evaluation and deserves further study. Published by Elsevier Ireland Ltd. JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology AU - Lungu, Codrin AU - Tarulli, Andrew W AU - Tarsy, Daniel AU - Mongiovi, Phillip AU - Vanderhorst, Veronique G AU - Rutkove, Seward B AD - Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, United States. lunguci@ninds.nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 1027 EP - 1031 VL - 122 IS - 5 KW - Index Medicus KW - Myography KW - Humans KW - Electric Impedance KW - Middle Aged KW - Male KW - Female KW - Torticollis -- physiopathology KW - Muscle, Skeletal -- physiopathology KW - Torticollis -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/859052991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+neurophysiology+%3A+official+journal+of+the+International+Federation+of+Clinical+Neurophysiology&rft.atitle=Quantifying+muscle+asymmetries+in+cervical+dystonia+with+electrical+impedance%3A+a+preliminary+assessment.&rft.au=Lungu%2C+Codrin%3BTarulli%2C+Andrew+W%3BTarsy%2C+Daniel%3BMongiovi%2C+Phillip%3BVanderhorst%2C+Veronique+G%3BRutkove%2C+Seward+B&rft.aulast=Lungu&rft.aufirst=Codrin&rft.date=2011-05-01&rft.volume=122&rft.issue=5&rft.spage=1027&rft.isbn=&rft.btitle=&rft.title=Clinical+neurophysiology+%3A+official+journal+of+the+International+Federation+of+Clinical+Neurophysiology&rft.issn=1872-8952&rft_id=info:doi/10.1016%2Fj.clinph.2010.09.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-15 N1 - Date created - 2011-03-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurology. 2005 Aug 9;65(3):451-2 [16087913] Mov Disord. 1997 Jul;12(4):570-5 [9251076] Clin Neurophysiol. 2006 Jun;117(6):1244-8 [16644269] Muscle Nerve. 2006 Nov;34(5):595-602 [16881067] Neurology. 2006 Dec 26;67(12):2230-2 [17190951] Parkinsonism Relat Disord. 2007 Oct;13(7):411-6 [17442609] Clin Neurophysiol. 2007 Nov;118(11):2413-8 [17897874] Plast Reconstr Surg. 2007 Dec;120(7):1823-33 [18090744] Neurotherapeutics. 2008 Apr;5(2):320-30 [18394573] Neurology. 2008 May 6;70(19):1699-706 [18458230] Neurol Clin. 2008 May;26 Suppl 1:9-22 [18603165] Neurol Clin. 2008 May;26 Suppl 1:23-42 [18603166] J Neurosurg. 2008 Sep;109(3):405-9 [18759568] Conf Proc IEEE Eng Med Biol Soc. 2008;2008:3566-9 [19163479] J Clin Neuromuscul Dis. 2009 Mar;10(3):90-6 [19258856] Mov Disord. 2009 Jul 30;24(10):1494-503 [19489066] Clin Neurophysiol. 2009 Aug;120(8):1424-32 [19616996] Arch Phys Med Rehabil. 2009 Oct;90(10):1806-10 [19801075] Muscle Nerve. 2009 Dec;40(6):936-46 [19768754] Phys Med Biol. 1999 Oct;44(10):2409-29 [10533919] J Neurol. 2000 Oct;247(10):787-92 [11127535] J Electromyogr Kinesiol. 2001 Aug;11(4):231-46 [11532594] Muscle Nerve. 2002 Mar;25(3):390-7 [11870716] Mov Disord. 2003 Mar;18(3):303-12 [12621634] Rev Neurol (Paris). 2003 Oct;159(10 Pt 1):906-15 [14615680] Neurology. 1985 Jan;35(1):73-7 [3966004] J Neurol. 1992 Jan;239(1):9-15 [1541974] J Clin Neuroophthalmol. 1992 Jun;12(2):121-7 [1385821] Clin Chem. 1993 Apr;39(4):561-77 [8472349] Mov Disord. 1997 Jan;12(1):100-2 [8990061] Muscle Nerve. 2005 Sep;32(3):335-41 [15948202] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.clinph.2010.09.013 ER - TY - JOUR T1 - The Mu Opioid Receptor Is Not Involved in EthanolaStimulated Dopamine Release in the Ventral Striatum of C57BL/6J Mice AN - 1758355781; 14703510 AB - Background: The mu opioid receptor (MOR) has previously been found to regulate ethanol-stimulated dopamine release under some, but not all, conditions. A difference in ethanol-evoked dopamine release between male and female mixed background C57BL/6J-129SvEv mice led to questions about its ubiquitous role in these effects of ethanol. Using congenic C57BL/6J MOR knockout (KO) mice and C57BL/6J mice pretreated with an irreversible MOR antagonist, we investigated the function of this receptor in ethanol-stimulated dopamine release. Methods: Microdialysis was used to monitor dopamine release and ethanol clearance in MOR -/-, +/+, and +/- . male and female mice after intraperitoneal (i.p.) injections of 1.0, 2.0, and 3.0g/kg ethanol (or saline). We also measured the increase in dopamine release after 5mg/kg morphine (i.p.) in male and female MOR+/+ and -/- mice. In a separate experiment, male C57BL/6J mice were pretreated with either the irreversible MOR antagonist beta funaltrexamine (BFNA) or vehicle, and dopamine levels were monitored after administration of 2g/kg ethanol or 5mg/kg morphine. Results: Although ethanol-stimulated dopamine release at all the 3 doses of alcohol tested, there were no differences between MOR+/+, -/-, and +/- mice in these effects. Female mice had a more prolonged effect compared to males at the 1g/kg dose. Administration of 2g/kg ethanol also caused a similar increase in dopamine levels in both saline-pretreated and BFNA-pretreated mice. Five mg/kg morphine caused a significant increase in dopamine levels in MOR+/+ mice but not in MOR-/- mice and in saline-pretreated mice but not in BFNA-pretreated mice. Intraperitoneal saline injections had a significant, albeit small and transient, effect on dopamine release when given in a volume equivalent to the ethanol doses, but not in a volume equivalent to the 5mg/kg morphine dose. Ethanol pharmacokinetics were similar in all genotypes and both sexes at each dose and in both pretreatment groups. Conclusions: MOR is not involved in ethanol-stimulated dopamine release in the ventral striatum of C57BL/6J mice. JF - Alcoholism: Clinical and Experimental Research AU - Ramachandra, Vorani AU - Kang, Francis AU - Kim, Christine AU - Nova, Alan S AU - Bajaj, Ankur AU - Scott Hall, F AU - Uhl, George R AU - Gonzales, Rueben A AD - From The University of Texas at Austin (VR, FK, CK, ASN, AB, RAG), PHARaPharmacology, Austin, Texas; Molecular Biology Branch (FSH, GRU), National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland. PY - 2011 SP - 929 EP - 938 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 35 IS - 5 SN - 0145-6008, 0145-6008 KW - Toxicology Abstracts KW - Morphine KW - Receptor mechanisms KW - Genotypes KW - Drug abuse KW - Pharmacokinetics KW - Microdialysis KW - Dopamine KW - Neostriatum KW - Alcoholism KW - Opioid receptors (type mu) KW - Ethanol KW - Sex KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1758355781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%3A+Clinical+and+Experimental+Research&rft.atitle=The+Mu+Opioid+Receptor+Is+Not+Involved+in+EthanolaStimulated+Dopamine+Release+in+the+Ventral+Striatum+of+C57BL%2F6J+Mice&rft.au=Ramachandra%2C+Vorani%3BKang%2C+Francis%3BKim%2C+Christine%3BNova%2C+Alan+S%3BBajaj%2C+Ankur%3BScott+Hall%2C+F%3BUhl%2C+George+R%3BGonzales%2C+Rueben+A&rft.aulast=Ramachandra&rft.aufirst=Vorani&rft.date=2011-05-01&rft.volume=35&rft.issue=5&rft.spage=929&rft.isbn=&rft.btitle=&rft.title=Alcoholism%3A+Clinical+and+Experimental+Research&rft.issn=01456008&rft_id=info:doi/10.1111%2Fj.1530-0277.2010.01423.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Document feature - figure 7 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Microdialysis; Morphine; Dopamine; Receptor mechanisms; Alcoholism; Neostriatum; Opioid receptors (type mu); Genotypes; Drug abuse; Pharmacokinetics; Sex; Ethanol DO - http://dx.doi.org/10.1111/j.1530-0277.2010.01423.x ER - TY - JOUR T1 - A Barrel of Monkeys: scAAV8 Gene Therapy for Hemophilia in Nonhuman Primates AN - 1668264649; PQ0001269858 AB - In this issue of Molecular Therapy, Nathwani et al. present outstanding nonhuman primate (NHP) experiments[1] performed as a prelude to a human trial that has already been hailed as achieving the "holy grail" of hemophilia B gene therapy.2 The aims of the preclinical studies were to determine the safety, efficacy, dose requirements, and immune responses after peripheral intravenous delivery of a self-complementary adeno-associated viral vector (AAV), sc-AAV-LP1-hFIXco, pseudotyped with either AAV8 or AAV5 capsid. These studies describe the treatment and long-term outcome of SC-AAV2/8-LP1-hFIXco gene therapy in one of the largest NHP cohorts studied to date. Because these experiments underlie the first test of an AAV serotype 8 vector in human clinical trials, they have particular relevance not only to hemophilia, but to any disorder that may be treated by liver-directed gene therapy. JF - Molecular Therapy AU - Chandler, Randy J AU - Venditti, Charles P AD - Organic Acid Research Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA; Institute for Biomedical Sciences, George Washington University, Washington, DC, USA, venditti@mail.nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 826 EP - 827 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 19 IS - 5 SN - 1525-0016, 1525-0016 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Expression vectors KW - Capsids KW - Intravenous administration KW - Serotypes KW - Gene therapy KW - Immune response KW - Clinical trials KW - Adeno-associated virus KW - Hemophilia KW - G 07720:Immunogenetics KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668264649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=A+Barrel+of+Monkeys%3A+scAAV8+Gene+Therapy+for+Hemophilia+in+Nonhuman+Primates&rft.au=Chandler%2C+Randy+J%3BVenditti%2C+Charles+P&rft.aulast=Chandler&rft.aufirst=Randy&rft.date=2011-05-01&rft.volume=19&rft.issue=5&rft.spage=826&rft.isbn=&rft.btitle=&rft.title=Molecular+Therapy&rft.issn=15250016&rft_id=info:doi/10.1038%2Fmt.2011.73 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Capsids; Expression vectors; Intravenous administration; Serotypes; Gene therapy; Immune response; Clinical trials; Hemophilia; Adeno-associated virus DO - http://dx.doi.org/10.1038/mt.2011.73 ER - TY - JOUR T1 - Intellectual disability in India: the evolving patterns of care AN - 1417549266; 201315535 AB - Intellectual disability was recognised in ancient Indian literature, but organised services have a history of just five decades. India shares many features of low- and middle-income (LAMI) countries regarding intellectual disability. There is a low level of awareness about its nature, causes and interventions. One can come across many superstitions, myths and misconceptions about intellectual disability. In general, services are inadequate, being concentrated in big cities and urban areas. There is generally limited access to support services and few government benefits, and these, in any case, are often of little value (World Health Organization, 2007). Locally and nationally, there are few relevant and reliable epidemiological data on the prevalence of intellectual disability. However, there have been some positive developments within the past three decades, and they are the focus of this paper. Adapted from the source document. JF - International Psychiatry AU - Girimaji, Satish Chandra AD - Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India girimaji@nimhans.kar.nic.in Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 29 PB - Royal College of Psychiatrists, London UK VL - 8 IS - 2 SN - 1749-3676, 1749-3676 KW - Myths KW - Support services KW - Superstitions KW - Learning disabilities KW - Prevalence KW - India KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1417549266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Psychiatry&rft.atitle=Intellectual+disability+in+India%3A+the+evolving+patterns+of+care&rft.au=Girimaji%2C+Satish+Chandra&rft.aulast=Girimaji&rft.aufirst=Satish&rft.date=2011-05-01&rft.volume=8&rft.issue=2&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=International+Psychiatry&rft.issn=17493676&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-08-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Learning disabilities; India; Prevalence; Support services; Superstitions; Myths ER - TY - JOUR T1 - A novel high-affinity human monoclonal antibody to mesothelin AN - 1399905889; 16690021 AB - Mesothelin is a glycosylphosphatidylinositol-anchored glycoprotein that is highly expressed on the cell surface of mesothelioma, ovarian cancer and other malignant tumors. The interaction between mesothelin and CA125 (also called MUC16) may facilitate the implantation and metastasis of tumors in the peritoneal cavity. A desirable therapeutic agent involves finding a fully human monoclonal antibody (mAb) that binds to mesothelin or CA125 and inhibits their interaction. Here, we report the identification of a novel human mAb to mesothelin. HN1, a human single-chain Fv specific for mesothelin, was isolated from a naive human single-chain variable fragment (scFv) phage display library. To investigate HN1 as a potential therapeutic, we generated a fully human IgG with the 1 heavy chain and the Delta *k light chain and an immuntoxin by fusing the HN1 scFv to a truncated Pseudomonas exotoxin A. The HN1 IgG kills cancer cells with very strong antibody-dependent cell-mediated cytotoxicity. HN1 binds a conformation-sensitive epitope in human mesothelin with high affinity (KD = 3 nM). The HN1 epitope is different from that of SS1, a mouse Fv used to develop therapeutic antibodies that are currently in clinical trials. HN1 binds to cell surface-associated mesothelin on human mesothelioma, ovarian cancer, lung adenocarcinoma and pancreatic cancer cells. In addition, HN1 can functionally block the interaction of mesothelin and CA125 on cancer cells. Most importantly, because the HN1 immuntoxin kills mesothelin-expressing cancer cells with high cytotoxic activity, we believe that it has significant potential for mesothelin-expressing cancer treatment and diagnosis. Published 2010 UICC. This article is a US Government work and, as such, is in the public domain of the United States of America. JF - International Journal of Cancer AU - Ho, Mitchell AU - Feng, Mingqian AU - Fisher, Robert J AU - Rader, Christoph AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, homi@mail.nih.gov Y1 - 2011/05/01/ PY - 2011 DA - 2011 May 01 SP - 2020 EP - 2030 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 128 IS - 9 SN - 1097-0215, 1097-0215 KW - Biotechnology and Bioengineering Abstracts KW - Ovarian cancer KW - Light chains KW - Monoclonal antibodies KW - Peritoneum KW - Phage display KW - Pancreatic cancer KW - Pseudomonas KW - Tumors KW - exotoxin A KW - Clinical trials KW - Fv KW - Metastases KW - Cytotoxicity KW - Immunoglobulin G KW - mesothelioma KW - Antibody-dependent cell-mediated cytotoxicity KW - Glycoproteins KW - Adenocarcinoma KW - Epitopes KW - Lung cancer KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1399905889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=A+novel+high-affinity+human+monoclonal+antibody+to+mesothelin&rft.au=Ho%2C+Mitchell%3BFeng%2C+Mingqian%3BFisher%2C+Robert+J%3BRader%2C+Christoph%3BPastan%2C+Ira&rft.aulast=Ho&rft.aufirst=Mitchell&rft.date=2011-05-01&rft.volume=128&rft.issue=9&rft.spage=2020&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=10970215&rft_id=info:doi/10.1002%2Fijc.25557 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ijc.25557/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-07-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Ovarian cancer; Light chains; Monoclonal antibodies; Phage display; Peritoneum; Pancreatic cancer; Tumors; Clinical trials; exotoxin A; Fv; Metastases; Cytotoxicity; Immunoglobulin G; mesothelioma; Antibody-dependent cell-mediated cytotoxicity; Glycoproteins; Adenocarcinoma; Epitopes; Lung cancer; Pseudomonas DO - http://dx.doi.org/10.1002/ijc.25557 ER - TY - JOUR T1 - RADIOTHERAPY AND CONCOMITANT DOCETAXEL IN HIGH-RISK PROSTATIC CANCER AN - 1356924824; 14971900 AB - Background: High-risk prostate cancer patients (cT3, N1, PSA >20 ng/ml and/or Gleason score greater than or equal to 8) have a 5-year biochemical failure rate after surgery or radiation of 50% or greater. Neoadjuvant, concomitant and adjuvant hormonotherapy (HT) are currently the only systemic treatments with escalation dose of radiation therapy. Because of the heterogeneity of prostate cancer cells and the desire to improve the outcome with radiotherapy (RT), weekly chemotherapy during RT in localized, high-risk prostate cancer is being explored. Docetaxel has demonstrated significant antitumor effect and impact on survival in hormone-refractory prostate cancer and a strong sensitization of tumor cells to radiation injury. Patients and Methods: From 2005 to 2010, 16 very high-risk patients were treated with high dose of RT and concomitant docetaxel. All patients had clinically (10/16) or pathologically (6/10) advanced disease. The median age was 65 (range: 56-65) years. Gleason score was: 8 in six patients, 9 in nine patients and 10 in one patient. The median PSA level at diagnosis was 15.45 (range: 2.5-71.3) ng/ml, while pre-RT PSA was 0.15 (range: 1.8-0.02) ng/ml. The median RT dose for all patients was 76 (range: 70-80) Gy, while for radical RT it was 80 (range: 76-80) Gy. Docetaxel was administered at a standard weekly dose (30 mg for patients with surface area <2 m super(2) and 40 mg for patients with greater than or equal to 2 m super(2)). The median cycle of chemotherapy was 7 (range: 2-8) months. All patients began HT before and during RT and continued the treatment for 2 years after RT. Results: At median follow-up of 36 (range: 8-60) months, only one patient, after 11 months, had recurrent disease (in the bones). The median PSA three months after the end of RT was 0.08 (range: 0.01-0.31) ng/ml, while at follow-up it was 0.1 (range: 0.01-0.4) ng/ml. With regard to toxicity: gastrointestinal grade I was reported in 12/16 patients and urological grade I was reported in 3/16 patients. One patient stopped chemotherapy infusion after two chemotherapy cycles because of systemic toxicity. Conclusion: These preliminary data confirmed the feasibility and the tolerability of weekly docetaxel in combination with RT in men at high risk of disease progression. No patient suffered performance status worsening during the scheduled treatment. At a median follow-up of 36 months, only 6% of patients experienced disease relapse and this was a remarkable result, considering that the patients were at very high risk. For such very high-risk patients, multimodal treatments combining HT, chemotherapy and RT will, possibly, be the treatment of choice in the future; however, at the moment, such treatments are only available in clinical trials and patients should be encouraged to participate in them. JF - Anticancer Research AU - Bortolus, R AU - Garbeglio, A AU - Catalano, G AU - Arcicasa, M AU - Rumeileh, IA AD - Cro IRCCS, National Cancer Institute, Aviano, Pn, Italy Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 1941 VL - 31 IS - 5 SN - 0250-7005, 0250-7005 KW - Toxicology Abstracts KW - Risk assessment KW - Cell survival KW - Age KW - Data processing KW - Injuries KW - Chemotherapy KW - Surface area KW - Radiotherapy KW - Adjuvants KW - Toxicity KW - Clinical trials KW - Tumor cells KW - Prostate cancer KW - Radiation KW - Risk factors KW - Surgery KW - Risk groups KW - Antitumor activity KW - Radicals KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1356924824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anticancer+Research&rft.atitle=RADIOTHERAPY+AND+CONCOMITANT+DOCETAXEL+IN+HIGH-RISK+PROSTATIC+CANCER&rft.au=Bortolus%2C+R%3BGarbeglio%2C+A%3BCatalano%2C+G%3BArcicasa%2C+M%3BRumeileh%2C+IA&rft.aulast=Bortolus&rft.aufirst=R&rft.date=2011-05-01&rft.volume=31&rft.issue=5&rft.spage=1941&rft.isbn=&rft.btitle=&rft.title=Anticancer+Research&rft.issn=02507005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Last updated - 2013-06-14 N1 - SubjectsTermNotLitGenreText - Cell survival; Risk assessment; Age; Data processing; Injuries; Surface area; Chemotherapy; Radiotherapy; Toxicity; Adjuvants; Tumor cells; Clinical trials; Prostate cancer; Radiation; Surgery; Risk factors; Risk groups; Radicals; Antitumor activity ER - TY - JOUR T1 - Placental characteristics as a proxy measure of serum hormone and protein levels during pregnancy with a male fetus AN - 1028023310; 16545414 AB - Objective: In utero exposure to steroid hormones may be related to risk of some cancers such as testicular germ cell tumors (TGCT). To determine whether placental characteristics are good surrogate measures of maternal biomarker levels, we evaluated the correlations in mothers of sons at higher (whites, n = 150) and lower (blacks, n = 150) risk of TGCT. Associations with birth weight were also examined. Methods: All mothers, participants in the Collaborative Perinatal Project, were primigravidas who gave birth to male singletons. Associations between placental weight and placental thickness and third-trimester biomarker levels were evaluated using linear regression. Partial correlation coefficients for placental characteristics and birth weight were also estimated. Results: Placental weight was positively correlated with alpha-fetoprotein (AFP), sex hormone-binding globulin (SHBG), testosterone, estradiol and estriol in whites, and AFP and estriol in blacks. Placental thickness was not associated with any biomarker. After adjustment for placental weight, birth weight was not correlated with any biomarker. Conclusions: In these data, placental weight was modestly correlated with third-trimester biomarker level; however, it appeared to be a better surrogate for third-trimester biomarker level than birth weight. Placental thickness had limited utility as a surrogate measure for biomarker levels. JF - Cancer Causes & Control AU - Trabert, Britton AU - Longnecker, Matthew P AU - Graubard, Barry I AU - Klebanoff, Mark A AU - Stanczyk, Frank Z AU - McGlynn, Katherine A AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Suite 550, Rockville, MD, 20852-7234, USA, trabertbl@mail.nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 689 EP - 695 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 22 IS - 5 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Bioindicators KW - Birth weight KW - Cancer KW - Hormones KW - Prenatal experience KW - Proteins KW - Steroid hormones KW - Tumors KW - males KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028023310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Placental+characteristics+as+a+proxy+measure+of+serum+hormone+and+protein+levels+during+pregnancy+with+a+male+fetus&rft.au=Trabert%2C+Britton%3BLongnecker%2C+Matthew+P%3BGraubard%2C+Barry+I%3BKlebanoff%2C+Mark+A%3BStanczyk%2C+Frank+Z%3BMcGlynn%2C+Katherine+A&rft.aulast=Trabert&rft.aufirst=Britton&rft.date=2011-05-01&rft.volume=22&rft.issue=5&rft.spage=689&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9741-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Last updated - 2012-07-27 N1 - SubjectsTermNotLitGenreText - Bioindicators; Birth weight; Prenatal experience; Proteins; males; Steroid hormones; Tumors; Hormones; Cancer DO - http://dx.doi.org/10.1007/s10552-011-9741-8 ER - TY - JOUR T1 - Establishing the Outcome Indicators for the Essential Nursing Competencies and Curricula Guidelines for Genetics and Genomics AN - 1023092173; 201213241 AB - The translation of genetics/genomics to clinical care has implications for nurses. The Essential Nursing Competencies and Curricula Guidelines for Genetics and Genomics, established by consensus, apply to all registered nurses. Learning outcomes and clinical practice indicators have been developed to provide additional guidance. The Essentials Advisory Group (EAG) established a team to establish the Outcome Indicators. A draft was developed based on published peer-reviewed documents and syllabi. The draft underwent three layers of review: (a) critique by the EAG; (b) review by representatives at a Genetics/Genomics Toolkit for Faculty meeting; and (c) review by workshop attendees of the American Association of Colleges of Nursing's baccalaureate and master's education conferences, followed by EAG's final approval. Outcome Indicators clarify specific knowledge areas and suggest clinical performance indicators for each competency. They provide the foundation to establish a competency-based education repository with outcome indicator mapping matrixes for genetic/genomic education resources. A gap analysis of education resources identified resource deficits, and online unfolding case studies were developed. Outcome Indicators assist the academic and continuing education nurse community to prepare the nursing workforce in genetics/genomics and provide a platform from which to build tools needed to achieve this goal. [Copyright Elsevier B.V.] JF - Journal of Professional Nursing AU - Calzone, Kathleen A AU - Jenkins, Jean AU - Prows, Cynthia A AU - Masny, Agnes AD - National Institutes of Health, National Cancer Institute, Center for Cancer Research, Genetics Branch calzonek@mail.nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 179 EP - 191 PB - Elsevier Ltd, The Netherlands VL - 27 IS - 3 SN - 8755-7223, 8755-7223 KW - Competency KW - Genetics KW - Genomics KW - Nursing education KW - Professional competence KW - Curriculum KW - Nursing KW - Drafts KW - Nurses KW - Labour force KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023092173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Professional+Nursing&rft.atitle=Establishing+the+Outcome+Indicators+for+the+Essential+Nursing+Competencies+and+Curricula+Guidelines+for+Genetics+and+Genomics&rft.au=Calzone%2C+Kathleen+A%3BJenkins%2C+Jean%3BProws%2C+Cynthia+A%3BMasny%2C+Agnes&rft.aulast=Calzone&rft.aufirst=Kathleen&rft.date=2011-05-01&rft.volume=27&rft.issue=3&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Journal+of+Professional+Nursing&rft.issn=87557223&rft_id=info:doi/10.1016%2Fj.profnurs.2011.01.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nursing; Nurses; Professional competence; Curriculum; Drafts; Labour force DO - http://dx.doi.org/10.1016/j.profnurs.2011.01.001 ER - TY - JOUR T1 - Simple targeted arterial rendering (STAR) technique: a novel and simple method to visualize the fetal cardiac outflow tracts AN - 1017973159; 16703843 AB - Objective To describe a novel and simple technique-simple targeted arterial rendering (STAR)-to visualize the fetal cardiac outflow tracts from dataset volumes obtained with spatiotemporal image correlation (STIC) and applying a new display technology (OmniView). Methods We developed a technique to image the outflow tracts by drawing three dissecting lines through the four-chamber view of the heart contained in a STIC volume dataset. Each line generated the following plane: (a) Line 1: ventricular septum en face with both great vessels (pulmonary artery anterior to the aorta); (b) Line 2: pulmonary artery with continuation into the longitudinal view of the ductal arch; and (c) Line 3: long-axis view of the aorta arising from the left ventricle. The pattern formed by all three lines intersecting approximately through the crux of the heart resembles a star. The technique was then tested in 50 normal fetal hearts at 15.3-40.4 weeks' gestation. To determine whether the technique could identify planes that departed from the normal images, we tested the technique in four cases with proven congenital heart defects (ventricular septal defect (VSD), transposition of great vessels, tetralogy of Fallot and pulmonary atresia with intact ventricular septum). Results The STAR technique was able to generate the intended planes in all 50 normal cases. In the abnormal cases, the STAR technique allowed identification of the VSD, demonstrated great vessel anomalies and displayed views that deviated from what was expected from the examination of normal hearts. Conclusions This novel and simple technique can be used to visualize the outflow tracts and ventricular septum en face in normal fetal hearts. Inability to obtain expected views or the appearance of abnormal views in the generated planes should raise the index of suspicion for congenital heart disease involving the great vessels and/or the ventricular septum. The STAR technique may simplify examination of the fetal heart and could reduce operator dependency. JF - Ultrasound in Obstetrics and Gynecology AU - Yeo, L AU - Romero, R AU - Jodicke, C AU - Kim, S K AU - Gonzalez, J M AU - Ogge, G AU - Lee, W AU - Kusanovic, J P AU - Vaisbuch, E AU - Hassan, S AD - Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD and Detroit, MI, USA, lyeo@med.wayne.edu Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 549 EP - 556 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 37 IS - 5 SN - 1469-0705, 1469-0705 KW - Biotechnology and Bioengineering Abstracts KW - Aorta KW - Fetuses KW - Gestation KW - Gynecology KW - Heart KW - Heart diseases KW - Lung KW - Obstetrics KW - Pulmonary artery KW - Septum KW - Transposition KW - Ultrasound KW - Ventricle KW - tetralogy of Fallot KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017973159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=Simple+targeted+arterial+rendering+%28STAR%29+technique%3A+a+novel+and+simple+method+to+visualize+the+fetal+cardiac+outflow+tracts&rft.au=Yeo%2C+L%3BRomero%2C+R%3BJodicke%2C+C%3BKim%2C+S+K%3BGonzalez%2C+J+M%3BOgge%2C+G%3BLee%2C+W%3BKusanovic%2C+J+P%3BVaisbuch%2C+E%3BHassan%2C+S&rft.aulast=Yeo&rft.aufirst=L&rft.date=2011-05-01&rft.volume=37&rft.issue=5&rft.spage=549&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=14690705&rft_id=info:doi/10.1002%2Fuog.8841 L2 - http://onlinelibrary.wiley.com/doi/10.1002/uog.8841/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Heart; Gynecology; Aorta; Transposition; Fetuses; Ventricle; Lung; Pulmonary artery; Gestation; Septum; tetralogy of Fallot; Ultrasound; Obstetrics; Heart diseases DO - http://dx.doi.org/10.1002/uog.8841 ER - TY - JOUR T1 - Prevention of Radiation-Induced Salivary Hypofunction Following hKGF Gene Delivery to Murine Submandibular Glands AN - 1017954816; 14785624 AB - PURPOSE: Salivary glands are significantly affected when head and neck cancer patients are treated by radiation. We evaluated the effect of human keratinocyte growth factor (hKGF) gene transfer to murine salivary glands on the prevention of radiation-induced salivary hypofunction. Experimental Design: A hybrid serotype 5 adenoviral vector encoding hKGF (AdLTR2EF1 alpha -hKGF) was constructed. Female C3H mice, 8 weeks old, were irradiated by single (15 Gy) or fractionated (6 Gy for 5 days) doses to induce salivary hypofunction. AdLTR2EF1 alpha -hKGF or AdControl was administered (108 - 1010 particles per gland) to both submandibular glands (SG) by retrograde ductal instillation before irradiation (IR). Salivary flow was measured following pilocarpine stimulation. Human KGF levels were measured by ELISA. SG cell proliferation was measured with bromodeoxyuridine labeling. Endothelial and progenitor or stem cells in SGs were measured by flow cytometry. The effect of SG hKGF production on squamous cell carcinoma (SCC VII) tumor growth was assessed. RESULTS: In 3 separate single-dose IR experiments, salivary flow rates of mice administered the AdLTR2EF1 alpha -hKGF vector were not significantly different from nonirradiated control mice (P > 0.05). Similarly, in 3 separate fractionated IR experiments, the hKGF-expressing vector prevented salivary hypofunction dramatically. Transgenic hKGF protein was found at high levels in serum and SG extracts. AdLTR2EF1 alpha -hKGF-treated mice showed increased cell proliferation and numbers of endothelial cells, compared with mice treated with AdControl. hKGF gene transfer had no effect on SCC VII tumor growth plus or minus radiation. CONCLUSIONS: hKGF gene transfer prevents salivary hypofunction caused by either single or fractionated radiation dosing in mice. The findings suggest a potential clinical application. Clin Cancer Res; 17(9); 2842-51. [copy ]2011 AACR. JF - Clinical Cancer Research AU - Zheng, Changyu AU - Cotrim, Ana P AU - Rowzee, Anne AU - Swaim, William AU - Sowers, Anastasia AU - Mitchell, James B AU - Baum, Bruce J AD - Authors' Affiliations: Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research and Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Y1 - 2011/05/01/ PY - 2011 DA - 2011 May 01 SP - 2842 EP - 2851 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 17 IS - 9 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Bromodeoxyuridine KW - Cell proliferation KW - Endothelial cells KW - Enzyme-linked immunosorbent assay KW - Expression vectors KW - Flow cytometry KW - Gene transfer KW - Head and neck cancer KW - Hybrids KW - I.R. radiation KW - Keratinocyte growth factor KW - Pilocarpine KW - Salivary gland KW - Serotypes KW - Stem cells KW - Submandibular gland KW - Therapeutic applications KW - Tumors KW - squamous cell carcinoma KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017954816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Prevention+of+Radiation-Induced+Salivary+Hypofunction+Following+hKGF+Gene+Delivery+to+Murine+Submandibular+Glands&rft.au=Zheng%2C+Changyu%3BCotrim%2C+Ana+P%3BRowzee%2C+Anne%3BSwaim%2C+William%3BSowers%2C+Anastasia%3BMitchell%2C+James+B%3BBaum%2C+Bruce+J&rft.aulast=Zheng&rft.aufirst=Changyu&rft.date=2011-05-01&rft.volume=17&rft.issue=9&rft.spage=2842&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Bromodeoxyuridine; Enzyme-linked immunosorbent assay; I.R. radiation; Serotypes; Therapeutic applications; squamous cell carcinoma; Tumors; Salivary gland; Keratinocyte growth factor; Expression vectors; Flow cytometry; Endothelial cells; Stem cells; Gene transfer; Hybrids; Head and neck cancer; Pilocarpine; Submandibular gland; Cell proliferation ER - TY - JOUR T1 - Treatment to Facilitate Reading Kana Sentences Through Improvement in Reading Sight Vocabulary: Children With Specific Reading Disabilities AN - 1010702418; 201204953 AB - The present study aimed to investigate effects of a treatment that promoted the process of reading sight vocabulary on the reading of kana sentences. The participants were 10 elementary school children with learning disabilities (LD), 5 of whom had specific reading disabilities and 5 of whom did not. Their vocal reaction times to meaningful kana words were measured. The number of correctly and fluently read phrases in the non-treatment sentences increased in the children with specific reading disabilities whose vocal reaction times to meaningful kana words had decreased after the treatment. These results suggest that effects of the treatment were observed in the reading of kana sentence by the children with specific reading disabilities. Those effects might have been a consequence of an improvement in the process of reading sight vocabulary. Adapted from the source document JF - Tokushu Kyoikugaku Kenkyu/Japanese Journal of Special Education AU - Goto, Takaaki AU - Kumazawa, Aya AU - Akatsuka, Megumi AU - Inagaki, Masumi AU - Koike, Toshihide AD - Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry (Kodaira-Shi, 187-8502) Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 41 EP - 50 VL - 49 IS - 1 SN - 0387-3374, 0387-3374 KW - Syllabaries (86460) KW - Reading Instruction (70950) KW - Learning Disabilities (45850) KW - Japanese (39500) KW - Reading Deficiencies (70900) KW - Children (11850) KW - article KW - 6511: learning disabilities; reading and writing disabilities KW - 4117: applied linguistics; reading instruction and remediation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010702418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tokushu+Kyoikugaku+Kenkyu%2FJapanese+Journal+of+Special+Education&rft.atitle=Treatment+to+Facilitate+Reading+Kana+Sentences+Through+Improvement+in+Reading+Sight+Vocabulary%3A+Children+With+Specific+Reading+Disabilities&rft.au=Goto%2C+Takaaki%3BKumazawa%2C+Aya%3BAkatsuka%2C+Megumi%3BInagaki%2C+Masumi%3BKoike%2C+Toshihide&rft.aulast=Goto&rft.aufirst=Takaaki&rft.date=2011-05-01&rft.volume=49&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Tokushu+Kyoikugaku+Kenkyu%2FJapanese+Journal+of+Special+Education&rft.issn=03873374&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - CODEN - TKKED6 N1 - SubjectsTermNotLitGenreText - Syllabaries (86460); Learning Disabilities (45850); Reading Deficiencies (70900); Children (11850); Japanese (39500); Reading Instruction (70950) ER - TY - JOUR T1 - Heparan sulfate modification of the transmembrane receptor CD47 is necessary for inhibition of T cell receptor signaling by thrombospondin-1. AN - 863431099; 21343308 AB - Cell surface proteoglycans on T cells contribute to retroviral infection, binding of chemokines and other proteins, and are necessary for some T cell responses to the matricellular glycoprotein thrombospondin-1. The major cell surface proteoglycans expressed by primary T cells and Jurkat T cells have an apparent M(r) > 200,000 and are modified with chondroitin sulfate and heparan sulfate chains. Thrombospondin-1 bound in a heparin-inhibitable manner to this proteoglycan and to a soluble form released into the medium. Based on mass spectrometry, knockdown, and immunochemical analyses, the proteoglycan contains two major core proteins as follows: amyloid precursor-like protein-2 (APLP2, apparent M(r) 230,000) and CD47 (apparent M(r) > 250,000). CD47 is a known thrombospondin-1 receptor but was not previously reported to be a proteoglycan. This proteoglycan isoform of CD47 is widely expressed on vascular cells. Mutagenesis identified glycosaminoglycan modification of CD47 at Ser(64) and Ser(79). Inhibition of T cell receptor signaling by thrombospondin-1 was lost in CD47-deficient T cells that express the proteoglycan isoform of APLP2, indicating that binding to APLP2 is not sufficient. Inhibition of CD69 induction was restored in CD47-deficient cells by re-expressing CD47 or an S79A mutant but not by the S64A mutant. Therefore, inhibition of T cell receptor signaling by thrombospondin-1 is mediated by CD47 and requires its modification at Ser(64). JF - The Journal of biological chemistry AU - Kaur, Sukhbir AU - Kuznetsova, Svetlana A AU - Pendrak, Michael L AU - Sipes, John M AU - Romeo, Martin J AU - Li, Zhuqing AU - Zhang, Lijuan AU - Roberts, David D AD - Laboratory of Pathology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20982, USA. Y1 - 2011/04/29/ PY - 2011 DA - 2011 Apr 29 SP - 14991 EP - 15002 VL - 286 IS - 17 KW - APLP2 protein, human KW - 0 KW - Amyloid beta-Protein Precursor KW - Antigens, CD47 KW - CD47 protein, human KW - Nerve Tissue Proteins KW - Receptors, Antigen, T-Cell KW - Thrombospondin 1 KW - Serine KW - 452VLY9402 KW - Heparitin Sulfate KW - 9050-30-0 KW - Index Medicus KW - Humans KW - Jurkat Cells KW - Endothelial Cells KW - Serine -- metabolism KW - Thrombospondin 1 -- physiology KW - Heparitin Sulfate -- metabolism KW - Receptors, Antigen, T-Cell -- antagonists & inhibitors KW - Antigens, CD47 -- metabolism KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863431099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Heparan+sulfate+modification+of+the+transmembrane+receptor+CD47+is+necessary+for+inhibition+of+T+cell+receptor+signaling+by+thrombospondin-1.&rft.au=Kaur%2C+Sukhbir%3BKuznetsova%2C+Svetlana+A%3BPendrak%2C+Michael+L%3BSipes%2C+John+M%3BRomeo%2C+Martin+J%3BLi%2C+Zhuqing%3BZhang%2C+Lijuan%3BRoberts%2C+David+D&rft.aulast=Kaur&rft.aufirst=Sukhbir&rft.date=2011-04-29&rft.volume=286&rft.issue=17&rft.spage=14991&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M110.179663 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-14 N1 - Date created - 2011-04-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 2006 Jul 12;25(13):3045-55 [16763549] Cardiovasc Res. 2006 Sep 1;71(4):785-93 [16820142] J Biol Chem. 2007 Jan 19;282(3):1805-18 [17098740] Int J Biochem Cell Biol. 2007;39(3):505-28 [17097330] Biochim Biophys Acta. 2007 Feb;1773(2):176-84 [17081636] Circ Res. 2007 Mar 16;100(5):712-20 [17293482] Nature. 2007 Apr 26;446(7139):1030-7 [17460664] Glycobiology. 2007 May;17(5):492-503 [17267519] J Biol Chem. 2007 Aug 17;282(33):24416-29 [17588944] J Immunol. 2007 Nov 1;179(9):5778-84 [17947650] J Immunol. 2007 Dec 1;179(11):7975-83 [18025246] Blood. 2008 Jan 15;111(2):613-23 [17890448] Cancer Res. 2002 Mar 1;62(5):1541-8 [11888933] J Cell Biol. 2002 Apr 29;157(3):509-19 [11980922] J Biol Chem. 2002 Nov 8;277(45):42859-66 [12218055] Immunity. 2003 Jan;18(1):27-39 [12530973] Exp Dermatol. 2003 Apr;12(2):204-12 [12702150] J Biol Chem. 2003 Aug 8;278(32):30106-14 [12773545] J Virol. 2003 Sep;77(18):9922-30 [12941902] Nat Rev Mol Cell Biol. 2003 Dec;4(12):926-37 [14685171] Annu Rev Immunol. 2004;22:129-56 [15032576] Fed Proc. 1985 Feb;44(2):386-93 [2578417] Proc Natl Acad Sci U S A. 1985 May;82(10):3197-201 [3858816] Cancer Res. 1988 Dec 1;48(23):6785-93 [3180088] J Cell Biol. 1990 Dec;111(6 Pt 1):2785-94 [2277087] Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2267-71 [1532254] Semin Thromb Hemost. 1992;18(2):243-51 [1631572] J Cell Biol. 1992 Nov;119(4):961-75 [1385449] J Immunol. 1993 Jul 1;151(1):149-58 [8100842] Mol Biol Cell. 1994 Apr;5(4):423-37 [7519904] Cell Mol Life Sci. 2008 Mar;65(5):728-42 [18193160] Cell Mol Life Sci. 2008 Mar;65(5):672-86 [18193164] J Cell Sci. 2008 Mar 15;121(Pt 6):784-95 [18285447] Mol Endocrinol. 2008 May;22(5):1226-37 [18292237] Immunol Cell Biol. 2008 May-Jun;86(4):381-4 [18195724] Mol Cell. 2008 Jul 25;31(2):266-77 [18657508] Arch Biochem Biophys. 2008 Oct 1;478(1):103-9 [18675774] J Biol Chem. 2009 Jan 9;284(2):1116-25 [19004835] Nat Rev Cancer. 2009 Mar;9(3):182-94 [19194382] Matrix Biol. 2009 Mar;28(2):110-9 [19284971] Sci Signal. 2009 Mar 31;2(64):pe18 [19336838] Blood. 2009 May 21;113(21):5176-85 [19270265] Cell Mol Life Sci. 2009 Nov;66(21):3421-34 [19629389] Cell Tissue Res. 2010 Jan;339(1):237-46 [19513755] J Biol Chem. 2010 Jan 15;285(3):1701-15 [19940140] Nat Biotechnol. 2010 Mar;28(3):203-7; 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AN - 864192362; 21217780 AB - The progression and negative outcome of a variety of human carcinomas are intimately associated with aberrant activity of the c-Met oncogene. The underlying cause of this dysregulation, however, remains a subject of discussion, as the majority of cancer patients do not present with activating mutations in c-Met receptor itself. In this study, we show that the oncogenic protease matriptase is ubiquitously co-expressed with the c-Met in human squamous cell carcinomas and amplifies migratory and proliferative responses of primary epithelial cells to the cognate ligand for c-Met, pro-hepatocyte growth factor/scatter factor (proHGF/SF), through c-Met and Gab1 signaling. Furthermore, the selective genetic ablation of c-Met from matriptase-expressing keratinocytes completely negates the oncogenic potential of matriptase. In addition, matriptase-dependent carcinoma formation could be blocked by the pharmacological inhibition of the Akt-mammalian target of Rapamycin (mTor) pathway. Our data identify matriptase as an initiator of c-Met-Akt-mTor-dependent signaling axis in tumors and reveal mTor activation as an essential component of matriptase/c-Met-induced carcinogenesis. The study provides a specific example of how epithelial transformation can be promoted by epigenetic acquisition of the capacity to convert a widely available paracrine growth factor precursor to its signaling competent state. JF - Oncogene AU - Szabo, R AU - Rasmussen, A L AU - Moyer, A B AU - Kosa, P AU - Schafer, J M AU - Molinolo, A A AU - Gutkind, J S AU - Bugge, T H AD - Oral and Pharyngeal Cancer Branch, NIDCR, NIH, Bethesda, MD 20892, USA. Y1 - 2011/04/28/ PY - 2011 DA - 2011 Apr 28 SP - 2003 EP - 2016 VL - 30 IS - 17 KW - Protein Precursors KW - 0 KW - pro-hepatocyte growth factor KW - Hepatocyte Growth Factor KW - 67256-21-7 KW - TOR Serine-Threonine Kinases KW - EC 2.7.1.1 KW - Proto-Oncogene Proteins c-met KW - EC 2.7.10.1 KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Serine Endopeptidases KW - EC 3.4.21.- KW - matriptase KW - Index Medicus KW - Gene Expression Regulation, Neoplastic KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Animals KW - Protein Precursors -- metabolism KW - TOR Serine-Threonine Kinases -- metabolism KW - Keratinocytes -- enzymology KW - Humans KW - Hepatocyte Growth Factor -- metabolism KW - Mice KW - Keratinocytes -- pathology KW - Keratinocytes -- metabolism KW - Up-Regulation KW - Signal Transduction KW - Carcinoma, Squamous Cell -- enzymology KW - Head and Neck Neoplasms -- pathology KW - Proto-Oncogene Proteins c-met -- deficiency KW - Proto-Oncogene Proteins c-met -- genetics KW - Head and Neck Neoplasms -- enzymology KW - Epithelial Cells -- enzymology KW - Serine Endopeptidases -- metabolism KW - Carcinoma, Squamous Cell -- pathology KW - Epithelial Cells -- pathology KW - Proto-Oncogene Proteins c-met -- metabolism KW - Carcinoma, Squamous Cell -- genetics KW - Head and Neck Neoplasms -- genetics KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864192362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=c-Met-induced+epithelial+carcinogenesis+is+initiated+by+the+serine+protease+matriptase.&rft.au=Szabo%2C+R%3BRasmussen%2C+A+L%3BMoyer%2C+A+B%3BKosa%2C+P%3BSchafer%2C+J+M%3BMolinolo%2C+A+A%3BGutkind%2C+J+S%3BBugge%2C+T+H&rft.aulast=Szabo&rft.aufirst=R&rft.date=2011-04-28&rft.volume=30&rft.issue=17&rft.spage=2003&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2010.586 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-23 N1 - Date created - 2011-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 2000 Jan 7;100(1):57-70 [10647931] Kidney Int. 2009 Oct;76(8):868-76 [19675527] J Biol Chem. 2000 Aug 25;275(34):26333-42 [10831593] EMBO J. 2000 Sep 1;19(17):4817-26 [10970872] J Biol Chem. 2000 Nov 24;275(47):36720-5 [10962009] Oncogene. 2002 May 23;21(23):3765-79 [12032844] Nat Rev Cancer. 2002 Jul;2(7):489-501 [12094235] J Biol Chem. 2002 Dec 6;277(49):47804-9 [12372819] Cancer Res. 2003 Mar 1;63(5):1101-5 [12615728] Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25 [14685170] Neoplasia. 2004 Jan-Feb;6(1):1-6 [15068665] Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4477-82 [15070743] Thromb Haemost. 2004 Sep;92(3):503-8 [15351846] Cancer Res. 2004 Oct 1;64(19):6965-72 [15466188] Cell. 1986 Jun 20;45(6):895-904 [2423252] EMBO J. 1992 Dec;11(13):4825-33 [1334458] J Invest Dermatol. 1993 Jul;101(1 Suppl):124S-129S [8326145] Nature. 1994 Mar 31;368(6470):419-24 [8133887] Nature. 1995 Feb 23;373(6516):699-702 [7854452] Nature. 1995 Feb 23;373(6516):702-5 [7854453] Genes Dev. 1995 Apr 1;9(7):794-807 [7705657] Biochem J. 2010 Mar 1;426(2):219-28 [20015050] Dev Cell. 2010 Jan 19;18(1):25-38 [20152175] Nat Rev Cancer. 2010 Apr;10(4):278-92 [20300104] Kidney Int. 2010 Jun;77(11):962-73 [20375988] Eur J Biochem. 1995 Apr 1;229(1):257-61 [7744037] Nature. 1995 Aug 31;376(6543):768-71 [7651534] J Clin Invest. 1998 Jan 15;101(2):321-6 [9435303] Curr Biol. 1998 Jan 29;8(3):125-34 [9443912] Blood Coagul Fibrinolysis. 1997 Mar;8(2):134-44 [9518045] Gastroenterology. 2004 Nov;127(5):1423-35 [15521012] Biochem J. 2005 Aug 15;390(Pt 1):125-36 [15839837] Genes Dev. 2005 Aug 15;19(16):1934-50 [16103220] Cancer Res. 2005 Nov 1;65(21):9953-61 [16267020] Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4046-51 [16537482] Am J Pathol. 2006 May;168(5):1513-25 [16651618] Mol Med. 2006 Jan-Mar;12(1-3):1-7 [16838070] Cancer Sci. 2006 Dec;97(12):1327-34 [16999819] Cell Mol Life Sci. 2006 Dec;63(24):2968-78 [17131055] Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5306-11 [17372204] J Cell Biol. 2007 Apr 9;177(1):151-62 [17403932] Clin Cancer Res. 2007 Sep 1;13(17):4964-73 [17785546] Int J Biochem Cell Biol. 2008;40(6-7):1297-316 [18191610] Curr Opin Genet Dev. 2008 Feb;18(1):87-96 [18406132] Cancer Res. 2008 Sep 1;68(17):7066-72 [18757421] Cancer Res. 2009 Apr 1;69(7):3021-31 [19318576] J Biol Chem. 2009 May 8;284(19):12917-23 [19286661] Oral Oncol. 2009 Apr-May;45(4-5):324-34 [18805044] Cancer Res. 2009 May 15;69(10):4159-66 [19435901] Transgenic Res. 1999 Aug;8(4):53-4 [10681148] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/onc.2010.586 ER - TY - JOUR T1 - Plasma pepsinogens, antibodies against Helicobacter pylori, and risk of gastric cancer in the Shanghai Women's Health Study Cohort AN - 876229217; 14883041 AB - Background: Circulating pepsinogens can indicate atrophic gastritis, a precursor of gastric cancer. We tested the association between gastric cancer and plasma pepsinogens and antibodies against Helicobacter pylori in a case-control study nested in a prospective cohort. Methods: We selected 141 gastric cancer cases and 282 incidence-density sampled controls. Plasma concentrations of pepsinogens 1 and 2 were measured using ELISA kits, and anti-H. pylori antibodies were measured using a kit specific to Chinese strains. Associations were estimated using conditional logistic regression models adjusted for potential confounders. Results: Gastric cancer subjects were more likely to be anti-H. pylori positive than controls, 97 vs 92%. A plasma pepsinogen 1 (PG1) concentration 6.6ngml super(-1) (75% of cases) was also associated with a significantly increased risk of gastric cancer (OR 3.62; (95% CI: 1.85-7.09). We also found that the PG1:2 ratio had a nearly linear association with gastric cancer risk. Conclusion: Lower plasma PG1:2 ratios are associated with a higher risk of gastric cancer. Furthermore, it appears that circulating pepsinogens 1 and 2 may be independently associated with the risk of gastric cancer. JF - British Journal of Cancer AU - Abnet, C C AU - Zheng, W AU - Ye, W AU - Kamangar, F AU - Ji, B-T AU - Persson, C AU - Yang, G AU - Li, H-L AU - Rothman, N AU - Shu, X-O AU - Gao, Y-T AU - Chow, W-H AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South, Room 320, 6120 Executive Boulevard, MSC 7232, Rockville, MD 20852, USA Y1 - 2011/04/26/ PY - 2011 DA - 2011 Apr 26 SP - 1511 EP - 1516 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 104 IS - 9 SN - 0007-0920, 0007-0920 KW - Health & Safety Science Abstracts; Microbiology Abstracts B: Bacteriology; Risk Abstracts KW - Helicobacter pylori KW - Antibodies KW - Enzyme-linked immunosorbent assay KW - Risk factors KW - Regression analysis KW - China, People's Rep., Shanghai KW - Females KW - Gastric cancer KW - Gastritis KW - Cancer KW - Models KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876229217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Plasma+pepsinogens%2C+antibodies+against+Helicobacter+pylori%2C+and+risk+of+gastric+cancer+in+the+Shanghai+Women%27s+Health+Study+Cohort&rft.au=Abnet%2C+C+C%3BZheng%2C+W%3BYe%2C+W%3BKamangar%2C+F%3BJi%2C+B-T%3BPersson%2C+C%3BYang%2C+G%3BLi%2C+H-L%3BRothman%2C+N%3BShu%2C+X-O%3BGao%2C+Y-T%3BChow%2C+W-H&rft.aulast=Abnet&rft.aufirst=C&rft.date=2011-04-26&rft.volume=104&rft.issue=9&rft.spage=1511&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fbjc.2011.77 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Antibodies; Risk factors; Regression analysis; Gastric cancer; Gastritis; Models; Females; Cancer; Helicobacter pylori; China, People's Rep., Shanghai DO - http://dx.doi.org/10.1038/bjc.2011.77 ER - TY - JOUR T1 - Generation of targeted Chlamydia trachomatis null mutants. AN - 863898576; 21482792 AB - Chlamydia trachomatis is an obligate intracellular bacterial pathogen that infects hundreds of millions of individuals globally, causing blinding trachoma and sexually transmitted disease. More effective chlamydial control measures are needed, but progress toward this end has been severely hampered by the lack of a tenable chlamydial genetic system. Here, we describe a reverse-genetic approach to create isogenic C. trachomatis mutants. C. trachomatis was subjected to low-level ethyl methanesulfonate mutagenesis to generate chlamydiae that contained less then one mutation per genome. Mutagenized organisms were expanded in small subpopulations that were screened for mutations by digesting denatured and reannealed PCR amplicons of the target gene with the mismatch specific endonuclease CEL I. Subpopulations with mutations were then sequenced for the target region and plaque-cloned if the desired mutation was detected. We demonstrate the utility of this approach by isolating a tryptophan synthase gene (trpB) null mutant that was otherwise isogenic to its parental clone as shown by de novo genome sequencing. The mutant was incapable of avoiding the anti-microbial effect of IFN-γ-induced tryptophan starvation. The ability to genetically manipulate chlamydiae is a major advancement that will enhance our understanding of chlamydial pathogenesis and accelerate the development of new anti-chlamydial therapeutic control measures. Additionally, this strategy could be applied to other medically important bacterial pathogens with no or difficult genetic systems. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Kari, Laszlo AU - Goheen, Morgan M AU - Randall, Linnell B AU - Taylor, Lacey D AU - Carlson, John H AU - Whitmire, William M AU - Virok, Dezso AU - Rajaram, Krithika AU - Endresz, Valeria AU - McClarty, Grant AU - Nelson, David E AU - Caldwell, Harlan D AD - Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. karil@niaid.nih.gov Y1 - 2011/04/26/ PY - 2011 DA - 2011 Apr 26 SP - 7189 EP - 7193 VL - 108 IS - 17 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Ethyl Methanesulfonate KW - 9H154DI0UP KW - Tryptophan Synthase KW - EC 4.2.1.20 KW - Index Medicus KW - Chlamydia Infections -- genetics KW - Ethyl Methanesulfonate -- pharmacology KW - Antineoplastic Agents, Alkylating -- pharmacology KW - Humans KW - Chlamydia Infections -- enzymology KW - Tryptophan Synthase -- metabolism KW - Chlamydia trachomatis -- enzymology KW - Chlamydia trachomatis -- genetics KW - Tryptophan Synthase -- genetics KW - Mutation KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863898576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Generation+of+targeted+Chlamydia+trachomatis+null+mutants.&rft.au=Kari%2C+Laszlo%3BGoheen%2C+Morgan+M%3BRandall%2C+Linnell+B%3BTaylor%2C+Lacey+D%3BCarlson%2C+John+H%3BWhitmire%2C+William+M%3BVirok%2C+Dezso%3BRajaram%2C+Krithika%3BEndresz%2C+Valeria%3BMcClarty%2C+Grant%3BNelson%2C+David+E%3BCaldwell%2C+Harlan+D&rft.aulast=Kari&rft.aufirst=Laszlo&rft.date=2011-04-26&rft.volume=108&rft.issue=17&rft.spage=7189&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.1102229108 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-24 N1 - Date created - 2011-04-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Biotechnol. 2000 Apr;18(4):455-7 [10748531] Infect Immun. 2010 Sep;78(9):3660-8 [20547745] J Clin Invest. 2003 Jun;111(11):1757-69 [12782678] Antimicrob Agents Chemother. 2003 Jul;47(7):2316-8 [12821487] J Bacteriol. 2004 Jul;186(13):4295-306 [15205432] N Engl J Med. 1978 Feb 23;298(8):428-35 [340951] N Engl J Med. 1978 Mar 2;298(9):490-5 [340953] N Engl J Med. 1978 Mar 9;298(10):540-9 [342952] Infection. 1982;10 Suppl 1:S10-8 [7044979] Can J Microbiol. 1994 Jul;40(7):583-91 [8076253] Nucleic Acids Res. 1998 Oct 15;26(20):4597-602 [9753726] Science. 1998 Oct 23;282(5389):754-9 [9784136] Antimicrob Agents Chemother. 2005 Mar;49(3):903-7 [15728882] Antimicrob Agents Chemother. 2005 Mar;49(3):1120-6 [15728912] Infect Immun. 2005 Oct;73(10):6407-18 [16177312] J Bacteriol. 2007 Feb;189(3):991-1003 [17122345] J Antimicrob Chemother. 2008 Jan;61(1):91-4 [18033786] J Infect Dis. 2008 Feb 1;197(3):449-56 [18199030] J Bacteriol. 2008 Mar;190(5):1605-14 [18083799] Infect Immun. 2008 Jun;76(6):2273-83 [18347045] Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):292-7 [19104068] Antimicrob Agents Chemother. 2009 Nov;53(11):4604-11 [19687238] J Biol Chem. 2002 Jul 26;277(30):26893-903 [12011099] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.1102229108 ER - TY - JOUR T1 - ATP binding to hemoglobin response gene 1 protein is necessary for regulation of the mating type locus in Candida albicans. AN - 862599705; 21372131 AB - HBR1 (hemoglobin response gene 1) is an essential gene in Candida albicans that positively regulates mating type locus MTLα gene expression and thereby regulates cell type-specific developmental genes. Hbr1p contains a phosphate-binding loop (P-loop), a highly conserved motif characteristic of ATP- and GTP-binding proteins. Recombinant Hbr1p was isolated in an oligomeric state that specifically bound ATP with K(d) ∼2 μM. ATP but not ADP, AMP, GTP, or dATP specifically protected Hbr1p from proteolysis by trypsin. Site-directed mutagenesis of the highly conserved P-loop lysine (K22Q) and the less conserved glycine (G19S) decreased the binding affinity for soluble ATP and ATP immobilized through its γ-phosphate. ATP bound somewhat more avidly than ATPγS to wild type and mutant Hbr1p. Although Hbr1p exhibits sequence motifs characteristic of adenylate kinases, and adenylate kinase and ATPase activities have been reported for the apparent human ortholog of Hbr1p, assays for adenylate kinase activity, autophosphorylation, and ATPase activity proved negative. Overexpression of wild type but not the mutant forms of Hbr1p restored MTlα2 expression in an HBR1/hbr1 mutant, indicating that ATP binding to the P-loop is necessary for this function of Hbr1p. JF - The Journal of biological chemistry AU - Peterson, Alexander W AU - Pendrak, Michael L AU - Roberts, David D AD - Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1500, USA. Y1 - 2011/04/22/ PY - 2011 DA - 2011 Apr 22 SP - 13914 EP - 13924 VL - 286 IS - 16 KW - Carrier Proteins KW - 0 KW - Fungal Proteins KW - Ligands KW - Nucleotides KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Adenylate Kinase KW - EC 2.7.4.3 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Adenylate Kinase -- chemistry KW - Candida -- metabolism KW - Chromatography, Gel -- methods KW - Circular Dichroism -- methods KW - Molecular Sequence Data KW - Nucleotides -- chemistry KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Mutation KW - Binding Sites KW - Gene Expression Regulation, Fungal KW - Candida albicans -- metabolism KW - Fungal Proteins -- physiology KW - Fungal Proteins -- metabolism KW - Fungal Proteins -- biosynthesis KW - Carrier Proteins -- physiology KW - Carrier Proteins -- biosynthesis KW - Adenosine Triphosphate -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862599705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=ATP+binding+to+hemoglobin+response+gene+1+protein+is+necessary+for+regulation+of+the+mating+type+locus+in+Candida+albicans.&rft.au=Peterson%2C+Alexander+W%3BPendrak%2C+Michael+L%3BRoberts%2C+David+D&rft.aulast=Peterson&rft.aufirst=Alexander&rft.date=2011-04-22&rft.volume=286&rft.issue=16&rft.spage=13914&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M110.180190 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-28 N1 - Date created - 2011-04-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Electrophoresis. 2005 Sep;26(18):3407-13 [16110465] Annu Rev Microbiol. 2005;59:233-55 [15910278] J Biol Chem. 2005 Oct 28;280(43):36429-41 [16079131] Mol Cell Biol. 2005 Dec;25(23):10352-64 [16287850] Mol Cell. 2006 Feb 3;21(3):319-30 [16455487] FEBS Lett. 2006 Jul 10;580(16):3811-7 [16781712] Curr Protoc Mol Biol. 2004 Sep;Chapter 10:Unit 10.4 [18265336] Biochemistry (Mosc). 2008 Jan;73(1):38-43 [18294127] Curr Protoc Protein Sci. 2004 Nov;Chapter 11:Unit 11.3 [18429249] Cell Mol Life Sci. 2010 Jun;67(11):1907-18 [20186459] Mol Microbiol. 2000 Feb;35(4):936-48 [10692169] Infect Immun. 1999 Dec;67(12):6652-62 [10569787] Mol Microbiol. 1999 Nov;34(4):792-8 [10564518] Science. 2000 Jul 14;289(5477):307-10 [10894780] Science. 2000 Jul 14;289(5477):310-3 [10894781] Proteins. 2000 Nov 15;41(3):415-27 [11025552] Eur J Biochem. 2002 Jan;269(1):2-12 [11784292] Nature. 2002 Jan 10;415(6868):141-7 [11805826] Cell. 2002 Aug 9;110(3):293-302 [12176317] Protein Eng. 2002 Oct;15(10):783-98 [12468712] Cell. 2003 Jun 27;113(7):919-33 [12837249] J Mol Biol. 2003 Oct 31;333(4):781-815 [14568537] Biochem Biophys Res Commun. 2004 Jan 30;314(1):229-34 [14715270] Eukaryot Cell. 2004 Jun;3(3):764-75 [15189997] J Biochem. 1981 Jan;89(1):285-96 [7217034] EMBO J. 1982;1(8):945-51 [6329717] Cell. 1985 Apr;40(4):767-74 [3886158] Biochemistry. 1990 Aug 14;29(32):7451-9 [2223776] Trends Biochem Sci. 1990 Nov;15(11):430-4 [2126155] Clin Microbiol Rev. 1992 Apr;5(2):183-203 [1576587] Comput Appl Biosci. 1993 Apr;9(2):197-9 [8481823] Nucleic Acids Res. 1995 May 11;23(9):1481-6 [7784200] J Mol Biol. 1998 May 22;278(5):983-97 [9600856] J Bacteriol. 1999 Mar;181(6):1868-74 [10074081] J Chromatogr. 1964 Oct;16:111-25 [14226338] Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):303-8 [15630091] Annu Rev Cell Dev Biol. 2005;21:105-31 [16212489] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M110.180190 ER - TY - JOUR T1 - Renal excretion of recombinant immunotoxins containing pseudomonas exotoxin. AN - 863423841; 21410247 AB - Recombinant immunotoxins BL22 (CAT-3888) and LMB-2, composed of Fv fragments of anti-CD22 and CD25 MAbs, respectively, have produced major responses in patients with hematologic malignancies, and are also associated with renal toxicity, particularly with BL22. Characterization of the renal excretion of recombinant immunotoxins, which have 2-4 h half-lives in plasma, has not been reported in humans. To study the renal excretion of recombinant immunotoxins, urine from patients treated with BL22 was collected and the recombinant protein visualized after trichloroacetic acid (TCA) precipitation or anion exchange chromatography. BL22 viewed by immunoblot was found in the urine of patients within 8 h after dosing as an intact protein, and progressively degraded to fragments of <20 kDa within 1 day. We studied the stability of BL22 and LMB-2 added to urine at different time points and pH. When exposed to urine ex vivo, BL22 time-dependent proteolysis was similar to that observed in treated patients. By N-terminal sequencing, proteolysis was documented at positions 348-349 and 350-351 of BL22, and 339-340 and 341-342 of LMB-2, and other proteolytic sites were observed as well. Our data suggest that BL22 is excreted into the urine in a potentially cytotoxic form, even after its plasma level declines, and may remain intact long enough to cause renal toxicity. JF - Bioconjugate chemistry AU - Traini, Roberta AU - Kreitman, Robert J AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20892, United States. Y1 - 2011/04/20/ PY - 2011 DA - 2011 Apr 20 SP - 736 EP - 740 VL - 22 IS - 4 KW - Immunotoxins KW - 0 KW - Recombinant Proteins KW - Index Medicus KW - Humans KW - Recombinant Proteins -- urine KW - Recombinant Proteins -- blood KW - Rectal Neoplasms -- blood KW - Immunotoxins -- urine KW - Immunotoxins -- administration & dosage KW - Rectal Neoplasms -- chemistry KW - Immunotoxins -- blood KW - Rectal Neoplasms -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863423841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+chemistry&rft.atitle=Renal+excretion+of+recombinant+immunotoxins+containing+pseudomonas+exotoxin.&rft.au=Traini%2C+Roberta%3BKreitman%2C+Robert+J&rft.aulast=Traini&rft.aufirst=Roberta&rft.date=2011-04-20&rft.volume=22&rft.issue=4&rft.spage=736&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+chemistry&rft.issn=1520-4812&rft_id=info:doi/10.1021%2Fbc1005152 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-16 N1 - Date created - 2011-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/bc1005152 ER - TY - JOUR T1 - Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer. AN - 868626824; 21501485 AB - Polycomb repressive complex 2 (PRC2) mediates gene silencing through histone H3K27 methylation. PRC2 components are over-expressed in metastatic prostate cancer (PC), and are required for cancer stem cell (CSC) self-renewal. 3-Dezaneplanocin-A (DZNeP) is an inhibitor of PRC2 with broad anticancer activity. we investigated the effects of DZNeP on cell proliferation, tumorigenicity and invasive potential of PC cell lines (LNCaP and DU145). Exploring GEO and Oncomine databases, we found that specific PRC2 genes (EED, EZH2, SUZ12) predict poor prognosis in PC. Non-toxic DZNeP concentrations completely eradicated LNCaP and DU145 prostatosphere formation, and significantly reduced the expression of CSC markers. At comparable doses, other epigenetic drugs were not able to eradicate CSCs. DZNeP was also able to reduce PC cell invasion. Cells pre-treated with DZNeP were significantly less tumorigenic (LNCaP) and formed smaller tumors (DU145) in immunocompromised mice. DZNeP is effective both in vitro and in vivo against PC cells. DZNeP antitumor activity is in part mediated by inhibition of CSC tumorigenic potential. JF - Molecular cancer AU - Crea, Francesco AU - Hurt, Elaine M AU - Mathews, Lesley A AU - Cabarcas, Stephanie M AU - Sun, Lei AU - Marquez, Victor E AU - Danesi, Romano AU - Farrar, William L AD - Cancer Stem Cell Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA. Y1 - 2011/04/18/ PY - 2011 DA - 2011 Apr 18 SP - 40 VL - 10 KW - Antineoplastic Agents KW - 0 KW - Histones KW - Polycomb-Group Proteins KW - RNA, Messenger KW - Repressor Proteins KW - Index Medicus KW - Animals KW - Humans KW - Disease Progression KW - Cell Line, Tumor KW - Mice KW - RNA, Messenger -- genetics KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Neoplastic Stem Cells -- metabolism KW - Neoplastic Stem Cells -- drug effects KW - Tumor Cells, Cultured KW - Cell Survival -- drug effects KW - Spheroids, Cellular -- drug effects KW - Histones -- metabolism KW - Methylation -- drug effects KW - Cell Movement -- drug effects KW - Xenograft Model Antitumor Assays KW - Mice, SCID KW - Histones -- genetics KW - Male KW - Prostatic Neoplasms -- metabolism KW - Cell Transformation, Neoplastic -- metabolism KW - Repressor Proteins -- metabolism KW - Cell Transformation, Neoplastic -- drug effects KW - Repressor Proteins -- genetics KW - Antineoplastic Agents -- pharmacology KW - Cell Transformation, Neoplastic -- genetics KW - Repressor Proteins -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/868626824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer&rft.atitle=Pharmacologic+disruption+of+Polycomb+Repressive+Complex+2+inhibits+tumorigenicity+and+tumor+progression+in+prostate+cancer.&rft.au=Crea%2C+Francesco%3BHurt%2C+Elaine+M%3BMathews%2C+Lesley+A%3BCabarcas%2C+Stephanie+M%3BSun%2C+Lei%3BMarquez%2C+Victor+E%3BDanesi%2C+Romano%3BFarrar%2C+William+L&rft.aulast=Crea&rft.aufirst=Francesco&rft.date=2011-04-18&rft.volume=10&rft.issue=&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer&rft.issn=1476-4598&rft_id=info:doi/10.1186%2F1476-4598-10-40 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-20 N1 - Date created - 2011-05-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Interv. 2008 Jun;8(3):140-2 [18693193] Cancer Res. 1998 Jan 1;58(1):95-101 [9426064] J Pathol. 2009 Jan;217(2):299-306 [19040209] Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):268-73 [19116269] Clin Exp Metastasis. 2009;26(5):433-46 [19221883] Differentiation. 2009 Jul;78(1):1-17 [19443100] Breast Cancer Res. 2009;11(4):R63 [19709408] Oncogene. 2009 Oct 8;28(40):3573-85 [19633685] Anticancer Agents Med Chem. 2009 Dec;9(10):1105-13 [19925394] Cancer Res. 2009 Dec 15;69(24):9211-8 [19934320] Mol Cancer Ther. 2010 Feb;9(2):461-70 [20124455] Oncogene. 2010 Feb 11;29(6):831-44 [19935703] Cell Mol Life Sci. 2010 Apr;67(7):1165-76 [20049504] BMC Genomics. 2010;11:324 [20500816] Mol Cancer. 2010;9:267 [20929579] Prog Drug Res. 2011;67:107-24 [21141727] Cancer Cell. 2005 Nov;8(5):393-406 [16286247] Cell. 2006 Apr 21;125(2):301-13 [16630818] Mol Cancer Ther. 2006 Apr;5(4):903-12 [16648560] Crit Rev Oncol Hematol. 2005 Dec;56(3):379-96 [16310371] Cell Cycle. 2006 Aug;5(16):1886-901 [16963837] Genes Dev. 2007 May 1;21(9):1050-63 [17437993] Cells Tissues Organs. 2007;185(1-3):162-74 [17587822] Eur Urol. 2007 Aug;52(2):455-63 [17134822] J Cell Biochem. 2007 Dec 1;102(5):1095-102 [17955492] Br J Cancer. 2008 Feb 26;98(4):756-65 [18268494] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Cell Stem Cell. 2008 Jun 5;2(6):511-2 [18522839] Acta Biochim Biophys Sin (Shanghai). 2008 Jul;40(7):643-50 [18604456] Cancer Res. 2008 Jul 15;68(14):5706-15 [18632623] Mol Cell Biol. 2008 Aug;28(15):4772-81 [18519590] Int J Cancer. 2011 Apr 15;128(8):1946-54 [20568112] PLoS One. 2011;6(3):e17388 [21408221] Antiviral Res. 2000 Feb;45(2):135-47 [10809022] Nature. 2002 Oct 10;419(6907):624-9 [12374981] Cancer Res. 2003 Nov 1;63(21):7291-300 [14612526] J Cell Biochem. 2004 Mar 1;91(4):649-61 [14991757] J Cancer Res Clin Oncol. 1983;105(1):20-3 [6833336] Eur J Drug Metab Pharmacokinet. 1995 Jul-Sep;20(3):197-202 [8751041] Oncogene. 2008 Dec 11;27(58):7274-84 [18806826] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1476-4598-10-40 ER - TY - JOUR T1 - Comparative genomics uncovers novel structural and functional features of the heterotrimeric GTPase signaling system AN - 923203576; 14604090 AB - Though the heterotrimeric G-proteins signaling system is one of the best studied in eukaryotes, its provenance and its prevalence outside of model eukaryotes remains poorly understood. We utilized the wealth of sequence data from recently sequenced eukaryotic genomes to uncover robust G-protein signaling systems in several poorly studied eukaryotic lineages such as the parabasalids, heteroloboseans and stramenopiles. This indicated that the G alpha subunit is likely to have separated from the ARF-like GTPases prior to the last eukaryotic common ancestor. We systematically identified the structure and sequence features associated with this divergence and found that most of the neomorphic positions in G alpha form a ring of residues centered on the nucleotide binding site, several of which are likely to be critical for interactions with the RGS domain for its GAP function. We also present evidence that in some of the potentially early branching eukaryotic lineages, like Trichomonas, G alpha is likely to function independently of the G beta I[sup3 subunits. We were able to identify previously unknown GI[sup3 subunits in Naegleria, suggesting that the trimeric version was already present by the time of the divergence of the heteroloboseans from the remaining eukaryotes. Evolution of G alpha subunits is dominated by several independent lineage-specific expansions (LSEs). In most of these cases there are concomitant, independent LSEs of RGS proteins along with an extraordinary diversification of their domain architectures. The diversity of RGS domains from Naegleria in particular, which has the largest complement of G alpha and RGS proteins for any eukaryote, provides new insights into RGS function and evolution. We uncovered a new class of soluble ligand receptors of bacterial origin with RGS domains and an extraordinary diversity of membrane-linked, redox-associated, adhesion-dependent and small molecule-induced G-protein signaling networks that evolved in early-branching eukaryotes, independently of parallel systems in animals. Furthermore, this newly characterized diversity of RGS domains helps in defining their ancestral conserved interfaces with G alpha and also those interfaces that are prone to extensive lineage-specific diversification and are thereby responsible for selectivity in G alpha -RGS interactions. Several mushrooms show LSEs of G alpha s but not of RGS proteins pointing to the probable differentiation of G alpha s in conjunction with mating-type diversity. When combined with the characterization of the 7TM receptors (GPCRs), it becomes apparent that, through much of eukaryotic evolution, cells contained both 7TM receptors that acted as GEFs and those as GAPs (with C-terminal RGS domains) for G alpha s. Only in some lineages like animals and stramenopiles the 7TM receptors were restricted to GEF only roles, probably due to selection imposed by the rate-constants of the G alpha s that underwent lineage-specific expansion in them. In the alveolate lineage the 7TM receptors occur independently of heterotrimeric G-proteins, suggesting the prevalence of G-protein-independent signaling in these organisms. JF - Gene AU - Anantharaman, Vivek AU - Abhiman, Saraswathi AU - de Souza, Robson F AU - Aravind, L AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, aravind@mail.nih.gov Y1 - 2011/04/15/ PY - 2011 DA - 2011 Apr 15 SP - 63 EP - 78 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 475 IS - 2 SN - 0378-1119, 0378-1119 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Data processing KW - Nucleotide sequence KW - Guanine nucleotide-binding protein KW - Basidiocarps KW - Naegleria KW - Differentiation KW - Alveolates KW - Structure-function relationships KW - Stramenopiles KW - genomics KW - Trichomonas KW - Evolution KW - Guanosinetriphosphatase KW - J 02310:Genetics & Taxonomy KW - G 07790:Other Microorganisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/923203576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Comparative+genomics+uncovers+novel+structural+and+functional+features+of+the+heterotrimeric+GTPase+signaling+system&rft.au=Anantharaman%2C+Vivek%3BAbhiman%2C+Saraswathi%3Bde+Souza%2C+Robson+F%3BAravind%2C+L&rft.aulast=Anantharaman&rft.aufirst=Vivek&rft.date=2011-04-15&rft.volume=475&rft.issue=2&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/10.1016%2Fj.gene.2010.12.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2013-08-23 N1 - SubjectsTermNotLitGenreText - Differentiation; Data processing; Structure-function relationships; Nucleotide sequence; Guanine nucleotide-binding protein; genomics; Basidiocarps; Evolution; Guanosinetriphosphatase; Alveolates; Stramenopiles; Trichomonas; Naegleria DO - http://dx.doi.org/10.1016/j.gene.2010.12.001 ER - TY - JOUR T1 - Filarial Infection Suppresses Malaria-Specific Multifunctional Th1 and Th17 Responses in Malaria and Filarial Coinfections AN - 904467293; 14624712 AB - The mechanisms underlying the modulation of both the malaria-specific immune response and the course of clinical malaria in the context of concomitant helminth infection are poorly understood. We used multiparameter flow cytometry to characterize the quality and the magnitude of malaria-specific T cell responses in filaria-infected and -uninfected individuals with concomitant asymptomatic Plasmodium falciparum malaria in Mali. In comparison with filarial-uninfected subjects, filarial infection was associated with higher ex vivo frequencies of CD4+ cells producing IL-4, IL-10, and IL-17A (p = 0.01, p = 0.001, and p = 0.03, respectively). In response to malaria Ag stimulation, however, filarial infection was associated with lower frequencies of CD4+ T cells producing IFN- gamma , TNF- alpha , and IL-17A (p < 0.001, p = 0.04, and p = 0.04, respectively) and with higher frequencies of CD4+IL10+T cells (p = 0.0005). Importantly, filarial infection was associated with markedly lower frequencies of malaria Ag-specific Th1 (p < 0.0001), Th17 (p = 0.012), and "TNF- alpha " (p = 0.0008) cells, and a complete absence of malaria-specific multifunctional Th1 cells. Filarial infection was also associated with a marked increase in the frequency of malaria-specific adaptive regulatory T/Tr1 cells (p = 0.024), and the addition of neutralizing anti-IL-10 Ab augmented the amount of Th1-associated cytokine produced per cell. Thus, among malaria-infected individuals, concomitant filarial infection diminishes dramatically the frequencies of malaria-specific Th1 and Th17 T cells, and alters the quality and magnitude of malaria-specific T cell responses. JF - Journal of Immunology AU - Metenou, Simon AU - Dembele, Benoit AU - Konate, Siaka AU - Dolo, Housseini AU - Coulibaly, Yaya I AU - Diallo, Abdallah A AU - Soumaoro, Lamine AU - Coulibaly, Michel E AU - Coulibaly, Siaka Y AU - Sanogo, Dramane AU - Doumbia, Salif S AU - Traore, Sekou F AU - Mahanty, Siddhartha AU - Klion, Amy AU - Nutman, Thomas B AD - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2011/04/15/ PY - 2011 DA - 2011 Apr 15 SP - 4725 EP - 4733 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA VL - 186 IS - 8 SN - 0022-1767, 0022-1767 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - gamma -Interferon KW - Parasites KW - Interleukin 4 KW - Human diseases KW - Mali KW - Helper cells KW - Immunology KW - Malaria KW - Plasmodium falciparum KW - Immunity KW - Infection KW - Defence mechanisms KW - Immunomodulation KW - Interleukin 10 KW - Public health KW - Flow cytometry KW - Antibodies KW - CD4 antigen KW - Lymphocytes T KW - Cytokines KW - Tumor necrosis factor- alpha KW - K 03350:Immunology KW - Q1 08484:Species interactions: parasites and diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904467293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Filarial+Infection+Suppresses+Malaria-Specific+Multifunctional+Th1+and+Th17+Responses+in+Malaria+and+Filarial+Coinfections&rft.au=Metenou%2C+Simon%3BDembele%2C+Benoit%3BKonate%2C+Siaka%3BDolo%2C+Housseini%3BCoulibaly%2C+Yaya+I%3BDiallo%2C+Abdallah+A%3BSoumaoro%2C+Lamine%3BCoulibaly%2C+Michel+E%3BCoulibaly%2C+Siaka+Y%3BSanogo%2C+Dramane%3BDoumbia%2C+Salif+S%3BTraore%2C+Sekou+F%3BMahanty%2C+Siddhartha%3BKlion%2C+Amy%3BNutman%2C+Thomas+B&rft.aulast=Metenou&rft.aufirst=Simon&rft.date=2011-04-15&rft.volume=186&rft.issue=8&rft.spage=4725&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Parasites; Human diseases; Immunology; Malaria; Immunity; Defence mechanisms; Public health; gamma -Interferon; Interleukin 4; Helper cells; Infection; Immunomodulation; Interleukin 10; CD4 antigen; Antibodies; Lymphocytes T; Cytokines; Tumor necrosis factor- alpha; Plasmodium falciparum; Mali ER - TY - JOUR T1 - Simple explanations before complex theories: Alternative interpretations of Sirotin and Das' observations AN - 876250778; 15124285 AB - We make a few additional points regarding our discussion with Sirotin and Das' 2009 Nature paper and their 2011 NeuroImage response to our commentary. While we find their data interesting in itself, we remain concerned with how the data are interpreted by the authors. We discuss two categories of methodological issues that limit the conclusions one can draw from their results. (1) The measures of fit quality between the optical and electrical data: kernel shape variation, variance of predicted/measured signals, and R[super]2, interact with each other and are confounded by the fact that one condition has a lower signal magnitude and therefore, lower signal-to-noise-ratio (SNR). (2) Hemodynamic responses to distinct events will be incorrectly or inefficiently estimated if the hemodynamic responses overlap across periodic trials that are not jittered and have an inter-trial interval less than 15 s. Most importantly, the overlapping responses across trials might cause transient effects that look similar to the anticipatory effects presented by Sirotin and Das. While their study demonstrates a potentially useful way to probe neurovascular coupling, we believe the current results have little practical relevance for interpreting hemodynamic measures of neural activity such as those used in fMRI. We conclude by making several suggestions for future analyses, which might help elucidate the mechanisms behind these observations and lead to a better understanding of how these observations relate to hemodynamic based measures of neural activation. JF - NeuroImage AU - Handwerker, Daniel A AU - Bandettini, Peter A AD - Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, NIH, MD, USA, Bandettini@nih.gov Y1 - 2011/04/15/ PY - 2011 DA - 2011 Apr 15 SP - 1419 EP - 1422 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 55 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Data processing KW - Functional magnetic resonance imaging KW - Probes KW - Hemodynamics KW - Kernels KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876250778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Simple+explanations+before+complex+theories%3A+Alternative+interpretations+of+Sirotin+and+Das%27+observations&rft.au=Handwerker%2C+Daniel+A%3BBandettini%2C+Peter+A&rft.aulast=Handwerker&rft.aufirst=Daniel&rft.date=2011-04-15&rft.volume=55&rft.issue=4&rft.spage=1419&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2011.01.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Data processing; Functional magnetic resonance imaging; Probes; Kernels; Hemodynamics DO - http://dx.doi.org/10.1016/j.neuroimage.2011.01.029 ER - TY - JOUR T1 - Hemodynamic signals not predicted? Not so: A comment on Sirotin and Das (2009) AN - 876231578; 15123928 AB - In their 2009 Nature article: "Anticipatory haemodynamic signals in sensory cortex not predicted by local neuronal activity," Yevginiy Sirotin and Aniruddha Das suggest that hemodynamic signals, the basis of functional MRI (fMRI), can arise without any measurable neuronal activity. They report that hemodynamic signals in visual cortex were associated with and time-locked to the anticipation of a visual stimulus, and importantly, without any associated neuronal activity as measured with direct electrophysiological recordings. In this commentary, we demonstrate, using an assessment of their own data, that their claims are not strongly supported. In fact, we found that specific LFP frequency ranges predicted with a high degree of accuracy, the "dark" or "anticipatory" hemodynamic response. For other frequency ranges, we found differences in phase but not magnitude of the measured and predicted hemodynamic response. Importantly, when comparing simply the magnitude as well as the time series standard deviation of the electrophysiological recordings with those of the measured hemodynamic responses, we found a direct correspondence of the dark/stimulated magnitude and standard deviation between the electrophysiological recordings and the hemodynamic responses. All of these analyses strongly imply that anticipatory hemodynamic responses are, in fact, accurately predicted in phase and magnitude by several LFP frequency bands, and are predicted in standard deviation and magnitude by the standard deviation and magnitude of even a wider range of LFP frequencies. We argue that rather than casting doubt on fMRI signal changes, these studies open up an interesting window into exploring more subtle neurovascular relationships. JF - NeuroImage AU - Handwerker, Daniel A AU - Bandettini, Peter A AD - Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, NIH, USA, Bandettini@nih.gov Y1 - 2011/04/15/ PY - 2011 DA - 2011 Apr 15 SP - 1409 EP - 1412 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 55 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876231578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Hemodynamic+signals+not+predicted%3F+Not+so%3A+A+comment+on+Sirotin+and+Das+%282009%29&rft.au=Handwerker%2C+Daniel+A%3BBandettini%2C+Peter+A&rft.aulast=Handwerker&rft.aufirst=Daniel&rft.date=2011-04-15&rft.volume=55&rft.issue=4&rft.spage=1409&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.04.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1016/j.neuroimage.2010.04.037 ER - TY - JOUR T1 - Susceptibility and mode of binding of the Mycobacterium tuberculosis cysteinyl transferase mycothiol ligase to tRNA synthetase inhibitors AN - 872140691; 14919247 AB - The cysteinyl transferase mycothiol ligase, or MshC, catalyzes the fourth step in the biosynthesis of the small molecular weight thiol mycothiol. MshC is essential for growth of Mycobacterium tuberculosis. Two groups of known aminoacyl tRNA synthetase inhibitors were evaluated for inhibition of M. tuberculosis MshC including aminoacyl adenosine analogs and natural products. Using enzyme assays, isothermal titration calorimetry and NMR, we show that MshC is selectively inhibited by cysteinyl sulfamoyl adenosine, and that discrimination occurs at the amino acid moiety. JF - Bioorganic and Medicinal Chemistry Letters AU - Gutierrez-Lugo, Maria-Teresa AU - Bewley, Carole A AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, United States, caroleb@mail.nih.gov Y1 - 2011/04/15/ PY - 2011 DA - 2011 Apr 15 SP - 2480 EP - 2483 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 21 IS - 8 SN - 0960-894X, 0960-894X KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Amino acids KW - tRNA KW - Enzymes KW - natural products KW - Mycothiol KW - Molecular weight KW - Titration KW - Thiols KW - Calorimetry KW - Tuberculosis KW - N.M.R. KW - Adenosine KW - Mycobacterium tuberculosis KW - W 30910:Imaging KW - J 02320:Cell Biology KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872140691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Susceptibility+and+mode+of+binding+of+the+Mycobacterium+tuberculosis+cysteinyl+transferase+mycothiol+ligase+to+tRNA+synthetase+inhibitors&rft.au=Gutierrez-Lugo%2C+Maria-Teresa%3BBewley%2C+Carole+A&rft.aulast=Gutierrez-Lugo&rft.aufirst=Maria-Teresa&rft.date=2011-04-15&rft.volume=21&rft.issue=8&rft.spage=2480&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2011.02.042 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Amino acids; Molecular weight; tRNA; Thiols; Titration; Enzymes; Calorimetry; N.M.R.; natural products; Tuberculosis; Adenosine; Mycothiol; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1016/j.bmcl.2011.02.042 ER - TY - JOUR T1 - DLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanism. AN - 862272638; 21372205 AB - The DLC1 gene encodes a Rho GTPase-activating protein (RhoGAP) that functions as a tumor suppressor in several common human cancers. The multidomain structure of DLC1 enables interaction with a number of other proteins. Here we report that the proinflammatory protein S100A10 (also known as p11), a key cell surface receptor for plasminogen which regulates pericellular proteolysis and tumor cell invasion, is a new binding partner of DLC1 in human cells. We determined that the 2 proteins colocalize in the cell cytoplasm and that their binding is mediated by central sequences in the central domain of DLC1 and the C-terminus of S100A10. Because the same S100A10 sequence also mediates binding to Annexin 2, we found that DLC1 competed with Annexin 2 for interaction with S100A10. DLC1 binding to S100A10 did not affect DLC1's RhoGAP activity, but it decreased the steady-state level of S100A10 expression in a dose-dependent manner by displacing it from Annexin 2 and making it accessible to ubiquitin-dependent degradation. This process attenuated plasminogen activation and resulted in inhibition of in vitro cell migration, invasion, colony formation, and anchorage-independent growth of aggressive lung cancer cells. These results suggest that a novel GAP-independent mechanism contributes to the tumor suppressive activity of DLC1, and highlight the importance and complexity of protein-protein interactions involving DLC1 in certain cancers. ©2011 AACR. JF - Cancer research AU - Yang, Xuyu AU - Popescu, Nicholas C AU - Zimonjic, Drazen B AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2011/04/15/ PY - 2011 DA - 2011 Apr 15 SP - 2916 EP - 2925 VL - 71 IS - 8 KW - ANXA2 protein, human KW - 0 KW - Annexin A2 KW - DLC1 protein, human KW - GTPase-Activating Proteins KW - S100 Proteins KW - S100 calcium binding protein A10 KW - Tumor Suppressor Proteins KW - Plasminogen KW - 9001-91-6 KW - Index Medicus KW - Down-Regulation KW - Breast Neoplasms -- pathology KW - Amino Acid Motifs KW - Cell Growth Processes -- physiology KW - Humans KW - HEK293 Cells KW - Ubiquitination KW - Breast Neoplasms -- metabolism KW - Plasminogen -- metabolism KW - Cell Line, Tumor KW - Protein Binding KW - Binding Sites KW - Carcinoma, Non-Small-Cell Lung -- metabolism KW - GTPase-Activating Proteins -- metabolism KW - Tumor Suppressor Proteins -- metabolism KW - Annexin A2 -- metabolism KW - S100 Proteins -- metabolism KW - Lung Neoplasms -- pathology KW - Lung Neoplasms -- metabolism KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862272638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=DLC1+interaction+with+S100A10+mediates+inhibition+of+in+vitro+cell+invasion+and+tumorigenicity+of+lung+cancer+cells+through+a+RhoGAP-independent+mechanism.&rft.au=Yang%2C+Xuyu%3BPopescu%2C+Nicholas+C%3BZimonjic%2C+Drazen+B&rft.aulast=Yang&rft.aufirst=Xuyu&rft.date=2011-04-15&rft.volume=71&rft.issue=8&rft.spage=2916&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-10-2158 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-15 N1 - Date created - 2011-04-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 1990 Dec;9(13):4207-13 [2148288] J Cancer Res Clin Oncol. 2004 Aug;130(8):480-6 [15185146] Biochemistry. 1998 Dec 1;37(48):16958-66 [9836589] Front Biosci. 2005 Jan 1;10:300-25 [15574370] Cancer Res. 2005 Oct 1;65(19):8861-8 [16204057] Cancer Res. 2006 Sep 1;66(17):8367-72 [16951145] J Cell Biol. 2007 Jan 1;176(1):43-9 [17190795] J Biol Chem. 2000 Dec 22;275(51):40096-105 [11007787] FASEB J. 2003 Feb;17(2):235-46 [12554702] J Biol Chem. 2004 Jan 16;279(3):2053-62 [14570893] Biochem Biophys Res Commun. 2007 Mar 30;355(1):72-7 [17292327] Proc Natl Acad Sci U S A. 2007 May 22;104(21):9012-7 [17517630] J Cell Mol Med. 2007 Sep-Oct;11(5):1185-207 [17979893] Mol Carcinog. 2008 May;47(5):326-37 [17932950] Cancer Gene Ther. 2008 Jun;15(6):371-81 [18369381] Int J Oncol. 2008 Jun;32(6):1285-91 [18497990] J Leukoc Biol. 2008 Jun;83(6):1484-92 [18339893] Genes Dev. 2008 Jun 1;22(11):1439-44 [18519636] Genes Dev. 2008 Jul 1;22(13):1724-30 [18593873] J Biol Chem. 2008 Jul 11;283(28):19192-200 [18434302] Cancer Res. 2008 Oct 1;68(19):7718-22 [18829524] BMC Cancer. 2008;8:261 [18793447] J Cell Sci. 2009 Jan 1;122(Pt 1):92-102 [19066281] J Cell Sci. 2009 Feb 1;122(Pt 3):414-24 [19158340] Genes Cells. 2009 Feb;14(2):227-41 [19170769] Oncogene. 2009 Mar 19;28(11):1401-9 [19151751] PLoS One. 2009;4(5):e5572 [19440389] Melanoma Res. 2009 Aug;19(4):215-25 [19521263] Adv Enzyme Regul. 2010;50(1):202-15 [19895840] J Biol Chem. 2004 Feb 13;279(7):5059-65 [14617629] Trends Cell Biol. 2004 Jul;14(7):377-85 [15246431] Mol Endocrinol. 1997 Nov;11(12):1858-67 [9369453] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-10-2158 ER - TY - JOUR T1 - A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics. AN - 858782937; 21300029 AB - ThioTEPA, an alkylating agent with anti-tumor activity, has been used as an effective anticancer drug since the 1950s. However, a complete understanding of how its alkylating activity relates to clinical efficacy has not been achieved, the total urinary excretion of thioTEPA and its metabolites is not resolved, and the mechanism of formation of the potentially toxic metabolites S-carboxymethylcysteine (SCMC) and thiodiglycolic acid (TDGA) remains unclear. In this study, the metabolism of thioTEPA in a mouse model was comprehensively investigated using ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOFMS) based-metabolomics. The nine metabolites identified in mouse urine suggest that thioTEPA underwent ring-opening, N-dechloroethylation, and conjugation reactions in vivo. SCMC and TDGA, two downstream thioTEPA metabolites, were produced from thioTEPA from two novel metabolites 1,2,3-trichloroTEPA (VII) and dechloroethyltrichloroTEPA (VIII). SCMC and TDGA excretion were increased about 4-fold and 2-fold, respectively, in urine following the thioTEPA treatment. The main mouse metabolites of thioTEPA in vivo were TEPA (II), monochloroTEPA (III) and thioTEPA-mercapturate (IV). In addition, five thioTEPA metabolites were detected in serum and all shared similar disposition. Although thioTEPA has a unique chemical structure which is not maintained in the majority of its metabolites, metabolomic analysis of its biotransformation greatly contributed to the investigation of thioTEPA metabolism in vivo, and provides useful information to understand comprehensively the pharmacological activity and potential toxicity of thioTEPA in the clinic. Copyright © 2011 Elsevier Inc. All rights reserved. JF - Biochemical pharmacology AU - Li, Fei AU - Patterson, Andrew D AU - Höfer, Constance C AU - Krausz, Kristopher W AU - Gonzalez, Frank J AU - Idle, Jeffrey R AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USA. lif3@mail.nih.gov Y1 - 2011/04/15/ PY - 2011 DA - 2011 Apr 15 SP - 1043 EP - 1053 VL - 81 IS - 8 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Thioglycolates KW - thiodiacetic acid KW - 483M3RG5GW KW - Carbocysteine KW - 740J2QX53R KW - Thiotepa KW - 905Z5W3GKH KW - Index Medicus KW - Spectrometry, Mass, Electrospray Ionization KW - Animals KW - Microsomes, Liver -- metabolism KW - Microsomes, Liver -- drug effects KW - Mice, Inbred C57BL KW - Chromatography, Liquid KW - Mice KW - Male KW - Multivariate Analysis KW - Metabolomics -- methods KW - Carbocysteine -- blood KW - Carbocysteine -- urine KW - Thioglycolates -- blood KW - Thioglycolates -- urine KW - Antineoplastic Agents, Alkylating -- blood KW - Thiotepa -- blood KW - Carbocysteine -- metabolism KW - Thioglycolates -- metabolism KW - Thiotepa -- metabolism KW - Antineoplastic Agents, Alkylating -- urine KW - Thiotepa -- urine KW - Metabolomics -- instrumentation KW - Antineoplastic Agents, Alkylating -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/858782937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=A+comprehensive+understanding+of+thioTEPA+metabolism+in+the+mouse+using+UPLC-ESI-QTOFMS-based+metabolomics.&rft.au=Li%2C+Fei%3BPatterson%2C+Andrew+D%3BH%C3%B6fer%2C+Constance+C%3BKrausz%2C+Kristopher+W%3BGonzalez%2C+Frank+J%3BIdle%2C+Jeffrey+R&rft.aulast=Li&rft.aufirst=Fei&rft.date=2011-04-15&rft.volume=81&rft.issue=8&rft.spage=1043&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=1873-2968&rft_id=info:doi/10.1016%2Fj.bcp.2011.01.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-26 N1 - Date created - 2011-03-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bcp.2011.01.024 ER - TY - JOUR T1 - Oxidative stress induces protein and DNA radical formation in follicular dendritic cells of the germinal center and modulates its cell death patterns in late sepsis. AN - 856173286; 21215311 AB - Profound depletion of follicular dendritic cells (FDCs) is a hallmark of sepsis-like syndrome, but the exact causes of the ensuing cell death are unknown. The cell death-driven depletion contributes to immunoparalysis and is responsible for most of the morbidity and mortality in sepsis. Here we have utilized immuno-spin trapping, a method for detection of free radical formation, to detect oxidative stress-induced protein and DNA radical adducts in FDCs isolated from the spleens of septic mice and from human tonsil-derived HK cells, a subtype of germinal center FDCs, to study their role in FDC depletion. At 24h post-lipopolysaccharide administration, protein radical formation and oxidation were significantly elevated in vivo and in HK cells as shown by ELISA and confocal microscopy. The xanthine oxidase inhibitor allopurinol and the iron chelator desferrioxamine significantly decreased the formation of protein radicals, suggesting the role of xanthine oxidase and Fenton-like chemistry in radical formation. Protein and DNA radical formation correlated mostly with apoptotic features at 24h and necrotic morphology of all the cell types studied at 48h with concomitant inhibition of caspase-3. The cytotoxicity of FDCs resulted in decreased CD45R/CD138-positive plasma cell numbers, indicating a possible defect in B cell differentiation. In one such mechanism, radical formation initiated by xanthine oxidase formed protein and DNA radicals, which may lead to cell death of germinal center FDCs. Published by Elsevier Inc. JF - Free radical biology & medicine AU - Chatterjee, Saurabh AU - Lardinois, Olivier AU - Bhattacharjee, Suchandra AU - Tucker, Jeff AU - Corbett, Jean AU - Deterding, Leesa AU - Ehrenshaft, Marilyn AU - Bonini, Marcelo G AU - Mason, Ronald P AD - National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. chatterjees2@niehs.nih.gov Y1 - 2011/04/15/ PY - 2011 DA - 2011 Apr 15 SP - 988 EP - 999 VL - 50 IS - 8 KW - Lipopolysaccharides KW - 0 KW - DNA KW - 9007-49-2 KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Microscopy, Confocal KW - Animals KW - Blotting, Western KW - Lipopolysaccharides -- pharmacology KW - Mice, Inbred C57BL KW - Enzyme-Linked Immunosorbent Assay KW - Mice KW - Male KW - Caspase 3 -- metabolism KW - Protein Biosynthesis KW - Sepsis -- pathology KW - Dendritic Cells -- metabolism KW - Oxidative Stress KW - Cell Death KW - Sepsis -- metabolism KW - DNA -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856173286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Oxidative+stress+induces+protein+and+DNA+radical+formation+in+follicular+dendritic+cells+of+the+germinal+center+and+modulates+its+cell+death+patterns+in+late+sepsis.&rft.au=Chatterjee%2C+Saurabh%3BLardinois%2C+Olivier%3BBhattacharjee%2C+Suchandra%3BTucker%2C+Jeff%3BCorbett%2C+Jean%3BDeterding%2C+Leesa%3BEhrenshaft%2C+Marilyn%3BBonini%2C+Marcelo+G%3BMason%2C+Ronald+P&rft.aulast=Chatterjee&rft.aufirst=Saurabh&rft.date=2011-04-15&rft.volume=50&rft.issue=8&rft.spage=988&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=1873-4596&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2010.12.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-17 N1 - Date created - 2011-03-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1990 Aug 23;346(6286):749-51 [2388695] FASEB J. 1987 Nov;1(5):358-64 [2824268] J Biol Chem. 1996 Jun 21;271(25):15182-6 [8662947] J Exp Med. 1997 Jan 6;185(1):165-70 [8996252] Exp Physiol. 1997 Mar;82(2):291-5 [9129943] Front Biosci (Elite Ed). 2009;1:277-87 [19482645] J Immunol. 2009 Sep 15;183(6):4055-66 [19717511] Free Radic Biol Med. 2009 Feb 15;46(4):454-61 [19049863] Immunology. 2005 Jan;114(1):2-10 [15606789] Cell. 2005 Mar 11;120(5):649-61 [15766528] J Immunol. 2005 May 15;174(10):6169-75 [15879113] Free Radic Res. 2005 Aug;39(8):845-51 [16036364] Curr Pharm Des. 2005;11(24):3141-58 [16178750] Am J Physiol Lung Cell Mol Physiol. 2000 Dec;279(6):L1005-28 [11076791] Apoptosis. 2000 Nov;5(5):415-8 [11256882] Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13549-53 [11717423] Semin Immunol. 2002 Aug;14(4):259-66 [12163301] FEBS Lett. 2002 Sep 11;527(1-3):289-92 [12220676] Free Radic Biol Med. 2002 Nov 1;33(9):1173-85 [12398925] J Immunol. 2003 Jul 15;171(2):909-14 [12847261] Nat Methods. 2006 Feb;3(2):123-7 [16432522] J Leukoc Biol. 2006 Mar;79(3):473-81 [16365154] Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4616-21 [16537416] J Immunol Methods. 2006 Jun 30;313(1-2):81-95 [16824539] Eur Respir J. 2006 Aug;28(2):268-74 [16510453] Nat Rev Immunol. 2006 Nov;6(11):813-22 [17039247] Sci STKE. 2006 Oct 24;2006(358):pe44 [17062895] Nat Protoc. 2007;2(3):512-22 [17406615] Am J Respir Crit Care Med. 2007 May 1;175(9):935-42 [17234903] J Surg Res. 2007 Jun 1;140(1):99-108 [17292408] J Immunol. 2007 Oct 1;179(7):4444-50 [17878340] J Neurosci. 2008 Apr 16;28(16):4115-22 [18417691] Crit Care. 2008;12(1):206 [18341705] J Immunol. 2008 May 15;180(10):6941-6 [18453615] JAMA. 2008 Jul 23;300(4):413-22 [18647984] Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E456-62 [18559982] Free Radic Biol Med. 2009 May 1;46(9):1260-6 [19353782] Nat Med. 2009 May;15(5):496-7 [19424209] Amino Acids. 2003 Dec;25(3-4):207-18 [14661084] Int Immunopharmacol. 2004 Apr;4(4):475-93 [15099526] Free Radic Biol Med. 2004 May 15;36(10):1214-23 [15110386] Free Radic Biol Med. 2004 Jun 1;36(11):1355-65 [15135171] J Immunol. 2004 Sep 1;173(5):3035-43 [15322163] J Free Radic Biol Med. 1985;1(1):3-25 [3013969] J Immunol. 1994 Oct 1;153(7):2951-61 [7522246] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2010.12.037 ER - TY - JOUR T1 - Akt1 deletion prevents lung tumorigenesis by mutant K-ras. AN - 862269170; 21242979 AB - K-ras mutations are associated with smoking-induced lung cancer and poor clinical outcomes. In mice, K-ras mutations are sufficient to induce lung tumors, which require phosphoinoside-3-kinase (PI3K) and further downstream, mammalian target of rapamycin (mTOR) activation. However, the roles of individual Akt isoforms that link PI3K and mTOR are unknown. Here, we show that deletion of Akt1 but not Akt2 or Akt3 prevents lung tumorigenesis in a tobacco carcinogen-induced model and a genetic model. Akt1 deletion prevented tumor initiation as well as tumor progression, coincident with decreased Akt signaling in tumor tissues. In contrast, deletion of Akt3 increased tumor multiplicity in the carcinogen model and increased tumor size in the genetic model. Fibroblasts lacking Akt1 are resistant to transformation by mutant K-ras and stimulation by epidermal growth factor. Human lung cancer cells with mutant K-ras and diminished Akt1 levels fail to grow in vivo. These data suggest that Akt1 is the primary Akt isoform activated by mutant K-ras in lung tumors, and that Akt3 may oppose Akt1 in lung tumorigenesis and lung tumor progression. Given that Akt inhibitors in clinical development as cancer therapeutics are not isoform selective, these studies support specific targeting of Akt1 to mitigate the effects of mutant K-ras in lung cancer. JF - Oncogene AU - Hollander, M C AU - Maier, C R AU - Hobbs, E A AU - Ashmore, A R AU - Linnoila, R I AU - Dennis, P A AD - Medical Oncology Branch, NCI, NIH, Bethesda, MD 20889, USA. Y1 - 2011/04/14/ PY - 2011 DA - 2011 Apr 14 SP - 1812 EP - 1821 VL - 30 IS - 15 KW - Akt1 protein, mouse KW - EC 2.7.11.1 KW - Proto-Oncogene Proteins c-akt KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Mice KW - Mice, Knockout KW - Proto-Oncogene Proteins c-akt -- genetics KW - Genes, ras KW - Lung Neoplasms -- prevention & control KW - Lung Neoplasms -- genetics KW - Proto-Oncogene Proteins c-akt -- physiology KW - Gene Deletion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862269170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Akt1+deletion+prevents+lung+tumorigenesis+by+mutant+K-ras.&rft.au=Hollander%2C+M+C%3BMaier%2C+C+R%3BHobbs%2C+E+A%3BAshmore%2C+A+R%3BLinnoila%2C+R+I%3BDennis%2C+P+A&rft.aulast=Hollander&rft.aufirst=M&rft.date=2011-04-14&rft.volume=30&rft.issue=15&rft.spage=1812&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2010.556 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-16 N1 - Date created - 2011-04-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2001 Apr 26;410(6832):1111-6 [11323676] CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300 [20610543] Br J Biomed Sci. 2001;58(3):159-63 [11575738] J Biol Chem. 2001 Oct 19;276(42):38349-52 [11533044] Cancer Res. 2002 Jan 1;62(1):89-98 [11782364] Mol Cell Biol. 2002 Apr;22(7):2111-23 [11884599] Mol Cell Biol. 2003 Jun;23(11):3859-71 [12748288] Cancer Cell. 2003 Aug;4(2):111-20 [12957286] Cancer Res. 2004 Jan 15;64(2):446-51 [14744754] Toxicology. 1981;21(2):95-104 [7281206] Cancer Res. 1989 Oct 1;49(19):5305-11 [2670201] Mol Cell Biol. 1996 Jul;16(7):3923-33 [8668210] Exp Lung Res. 1998 Jul-Aug;24(4):481-97 [9659579] Nat Genet. 1999 Oct;23(2):176-84 [10508513] Mol Cell Biol. 2005 Mar;25(5):1869-78 [15713641] Cancer Metastasis Rev. 2005 Jun;24(2):273-85 [15986137] Invest New Drugs. 2005 Oct;23(5):485-7 [16133800] Biochim Biophys Acta. 2005 Nov 25;1756(2):127-44 [16139957] J Clin Oncol. 2006 Jan 10;24(2):306-14 [16330671] Nature. 2006 May 25;441(7092):523-7 [16680151] Am J Respir Crit Care Med. 2008 Jul 1;178(1):60-73 [18310482] Cell. 2008 Jun 27;133(7):1292-1292.e1 [18585361] Neoplasia. 2008 Aug;10(8):866-72 [18683321] Expert Opin Ther Targets. 2008 Sep;12(9):1139-65 [18694380] Genes Dev. 2006 Jun 15;20(12):1569-74 [16778075] Cancer Cell. 2006 Oct;10(4):269-80 [17045205] Mol Cell Biol. 2006 Nov;26(21):8042-51 [16923958] Cancer Res. 2007 Jan 1;67(1):167-77 [17210696] Clin Cancer Res. 2007 Apr 1;13(7):2281-9 [17404113] Proc Natl Acad Sci U S A. 2007 May 1;104(18):7438-43 [17460049] Cell. 2007 Jun 1;129(5):957-68 [17540175] Cell. 2007 Jun 29;129(7):1261-74 [17604717] Nature. 2007 Jul 26;448(7152):439-44 [17611497] PLoS One. 2008;3(3):e0001722 [18320023] Cell Cycle. 2008 Mar 1;7(5):665-9 [18256540] Int J Biol Markers. 2008 Jan-Mar;23(1):1-9 [18409144] Curr Protoc Immunol. 2001 May;Chapter 10:Unit 10.17C [18432682] Br J Cancer. 2008 Oct 21;99(8):1265-8 [18813315] Curr Oncol Rep. 2009 Mar;11(2):102-10 [19216841] Cancer Genet Cytogenet. 2009 May;191(1):34-7 [19389506] Cancer Res. 2009 Jun 1;69(11):4885-93 [19487299] Br J Cancer. 2009 Jul 7;101(1):145-8 [19491896] Pigment Cell Melanoma Res. 2009 Aug;22(4):400-19 [19493313] Cell Cycle. 2009 Aug 15;8(16):2502-8 [19597332] Biomaterials. 2009 Oct;30(29):5844-52 [19640582] Oncogene. 2010 Jan 7;29(1):150-5 [19802009] Mol Cell Biol. 2010 Feb;30(3):601-12 [19933838] Int J Cancer. 2010 Jul 1;127(1):239-44 [19876913] Science. 2001 Jun 1;292(5522):1728-31 [11387480] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/onc.2010.556 ER - TY - JOUR T1 - Proportions of Kaposi Sarcoma, Selected Non-Hodgkin Lymphomas, and Cervical Cancer in the United States Occurring in Persons With AIDS, 1980-2007 AN - 904470381; 14698694 AB - Context Given the higher risk of AIDS-defining malignancies that include Kaposi sarcoma (KS), certain non-Hodgkin lymphomas (NHLs), and cervical cancer in persons with human immunodeficiency virus (HIV) infection, the HIV epidemic has likely contributed to the overall numbers of these cancers in the United States. OBJECTIVE: To quantify the proportions of KS, AIDS-defining NHLs, and cervical cancer in the United States that occurred among persons with AIDS from 1980 to 2007. Design, Setting, and Participants The HIV/AIDS Cancer Match Study (1980-2007) linked data from 16 US HIV/AIDS and cancer registries to identify cases with and without AIDS for KS, AIDS-defining NHLs (ie, diffuse large B-cell lymphoma [DLBCL], Burkitt lymphoma [BL], and central nervous system [CNS] lymphoma), and cervical cancer. Using linked data, we derived cancer rates for persons with and without AIDS. To estimate national counts, the rates were applied to national AIDS surveillance and US Census data. MAIN OUTCOME MEASURE: Proportion of AIDS-defining malignancies in the United States occurring in persons with AIDS. RESULTS: In the United States, an estimated 81.6% (95% confidence interval [CI], 81.2%-81.9%) of 83 252 KS cases, 6.0% (95% CI, 5.8%-6.1%) of 351 618 DLBCL cases, 19.9% (95% CI, 18.1%-21.7%) of 17 307 BL cases, 27.1% (95% CI, 26.1%-28.1%) of 27 265 CNS lymphoma cases, and 0.42% (95% CI, 0.37%-0.47%) of 375 452 cervical cancer cases occurred among persons with AIDS during 1980-2007. The proportion of KS and AIDS-defining NHLs in persons with AIDS peaked in the early 1990s (1990-1995: KS, 90.5% [95% CI, 90.2%-90.8%]; DLBCL, 10.2% [95% CI, 9.9%-10.5%]; BL, 27.8% [95% CI, 25.0%-30.5%]; and CNS lymphoma, 48.3% [95% CI, 46.7%-49.8%]; all P < .001 [compared with 1980-1989]) and then declined (2001-2007: KS, 70.5% [95% CI, 68.1%-73.0%]; DLBCL, 4.7% [95% CI, 4.3%-5.2%]; BL, 21.5% [95% CI, 17.7%-25.4%]; and CNS lymphoma, 12.9% [95% CI, 10.5%-15.3%]; all P < .001 [compared with 1990-1995]). The proportion of cervical cancers in persons with AIDS increased over time (1980-1989: 0.11% [95% CI, 0.09%-0.13%]; 2001-2007: 0.71% [95% CI, 0.51%-0.91%]; P < .001). CONCLUSIONS: In the United States, the estimated proportions of AIDS-defining malignancies that occurred among persons with AIDS were substantial, particularly for KS and some NHLs. Except for cervical cancer, the proportions of AIDS-defining malignancies occurring among persons with AIDS peaked in the mid-1990s and then declined. JF - JAMA: Journal of the American Medical Association AU - Shiels, Meredith S AU - Pfeiffer, Ruth M AU - Hall, HIrene AU - Li, Jianmin AU - Goedert, James J AU - Morton, Lindsay M AU - Hartge, Patricia AU - Engels, Eric A AD - Author Affiliations: National Cancer Institute, Rockville, Maryland (Drs Shiels, Pfeiffer, Goedert, Morton, Hartge, and Engels) Y1 - 2011/04/13/ PY - 2011 DA - 2011 Apr 13 SP - 1450 EP - 1459 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 305 IS - 14 SN - 0098-7484, 0098-7484 KW - Virology & AIDS Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - non-Hodgkin's lymphoma KW - census KW - Central nervous system KW - Acquired immune deficiency syndrome KW - Data processing KW - double prime B-cell lymphoma KW - Epidemics KW - Cervical cancer KW - Infection KW - Cancer KW - Burkitt's lymphoma KW - USA KW - Malignancy KW - Human immunodeficiency virus KW - Risk factors KW - infection KW - Sarcoma KW - Census KW - lymphoma KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22360:AIDS and HIV KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904470381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Proportions+of+Kaposi+Sarcoma%2C+Selected+Non-Hodgkin+Lymphomas%2C+and+Cervical+Cancer+in+the+United+States+Occurring+in+Persons+With+AIDS%2C+1980-2007&rft.au=Shiels%2C+Meredith+S%3BPfeiffer%2C+Ruth+M%3BHall%2C+HIrene%3BLi%2C+Jianmin%3BGoedert%2C+James+J%3BMorton%2C+Lindsay+M%3BHartge%2C+Patricia%3BEngels%2C+Eric+A&rft.aulast=Shiels&rft.aufirst=Meredith&rft.date=2011-04-13&rft.volume=305&rft.issue=14&rft.spage=1450&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Burkitt's lymphoma; Central nervous system; Malignancy; Acquired immune deficiency syndrome; Epidemics; double prime B-cell lymphoma; Data processing; Risk factors; Cervical cancer; Sarcoma; Census; Infection; census; non-Hodgkin's lymphoma; Human immunodeficiency virus; infection; lymphoma; Cancer; USA ER - TY - JOUR T1 - Transition from a plasmid to a chromosomal mode of replication entails additional regulators AN - 968154348; 14698991 AB - Plasmid origins of replication are rare in bacterial chromosomes, except in multichromosome bacteria. The replication origin of Vibrio cholerae chromosome II (chrII) closely resembles iteron-bearing plasmid origins. Iterons are repeated initiator binding sites in plasmid origins and participate both in replication initiation and its control. The control is mediated primarily by coupling of iterons via the bound initiators ("handcuffing"), which causes steric hindrance to the origin. The control in chrII must be different, since the timing of its replication is cell cycle-specific, whereas in plasmids it is random. Here we show that chrII uses, in addition to iterons, another kind of initiator binding site, named 39-mers. The 39-mers confer stringent control by increasing handcuffing of iterons, presumably via initiator remodeling. Iterons, although potential inhibitors of replication themselves, restrain the 39-mer-mediated inhibition, possibly by direct coupling ("heterohandcuffing"). We propose that the presumptive transition of a plasmid to a chromosomal mode of control requires additional regulators to increase the stringency of control, and as will be discussed, to gain the capacity to modulate the effectiveness of the regulators at different stages of the cell cycle. JF - Proceedings of the National Academy of Sciences, USA AU - Venkova-Canova, Tatiana AU - Chattoraj, Dhruba K AD - Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2011/04/12/ PY - 2011 DA - 2011 Apr 12 SP - 6199 EP - 6204 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 108 IS - 15 SN - 0027-8424, 0027-8424 KW - Genetics Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Replication KW - Cell cycle KW - chromosome II KW - Plasmids KW - Vibrio cholerae KW - Chromosomes KW - Replication initiation KW - Replication origins KW - Inhibitors KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968154348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Transition+from+a+plasmid+to+a+chromosomal+mode+of+replication+entails+additional+regulators&rft.au=Venkova-Canova%2C+Tatiana%3BChattoraj%2C+Dhruba+K&rft.aulast=Venkova-Canova&rft.aufirst=Tatiana&rft.date=2011-04-12&rft.volume=108&rft.issue=15&rft.spage=6199&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Chromosomes; Replication; Inhibitors; Plasmids; Replication initiation; Cell cycle; Replication origins; chromosome II; Vibrio cholerae ER - TY - JOUR T1 - A multicenter prospective phase II randomized trial of epirubicin/vinorelbine versus pegylated liposomal doxorubicin/vinorelbine as first-line treatment in advanced breast cancer. A GOIM study. AN - 863901927; 21481280 AB - To evaluate activity and tolerability of two anthracycline-containing regimens as first-line treatment for anthracycline-naïve relapsed breast cancer patients. Patients with relapsed breast cancer not previously treated with adjuvant anthracyclines were randomly assigned to epirubicin/vinorelbine (arm A: EPI/VNB, EPI 90 mg/m2 on day 1, VNB 25 mg/m2 on days 1,5 plus G-CSF subcutaneously on days 7-12, with cycles repeated every 21 days), or to pegylated liposomal doxorubicin/VNB (arm B: PLD/VNB, PLD 40 mg/m2 on day 1, VNB 30 mg/m2 on days 1, 15, with cycles repeated every 4 weeks). Primary objective was to evaluate the efficacy of the two regimens in terms of response rate, secondarily toxicity, progression free survival and overall survival. One hundred and four patients have been enrolled (arm A 54, arm B 50): characteristics were well balanced between the 2 arms. Responses were as follows: arm A, 3 (5.6%) CR, 20 (37%) PR, (ORR 42.6%, 95%CI 29.3%-55.9%); arm B, 8 (16%) CR, 18 (36%) PR, (ORR 52%, 95%CI 38.2%-65.8%). Median progression free survival was 10.7 months in arm A (95% CI, 8.7-12.6), and 8.8 months in arm B (95% CI, 7.1-10.5). Median overall survival was 34.6 months in arm A (95%CI, 19.5-49.8) and 24.8 months in arm B (95%CI, 15.7-33.9). As toxicity concerns, both treatment regimens were well tolerated; myelosuppression was the dose-limiting toxicity, with G3-4 neutropenia occurring in 18.5% and 22% of the patients of arm A and B, respectively. No relevant differences in main toxic effects have been observed between the two arms, except for alopecia, more common in arm A, and cutaneous toxicity, observed only in arm B. No clinical congestive heart failures have been observed, one case of tachyarrhythmia was reported after the last EPI/VNB cycle, and two reversible ≥ 20% LVEF decreases have been observed in arm A. Both anthracycline- containing regimens evaluated in the present study seem to be active and with a satisfactory tolerability in anthracycline-naïve relapsed breast cancer patients. JF - Journal of experimental & clinical cancer research : CR AU - Vici, Patrizia AU - Colucci, Giuseppe AU - Giotta, Francesco AU - Sergi, Domenico AU - Filippelli, Gianfranco AU - Perri, Pasquale AU - Botti, Claudio AU - Vizza, Enrico AU - Carpino, Armando AU - Pizzuti, Laura AU - Latorre, Agnese AU - Giannarelli, Diana AU - Lopez, Massimo AU - Di Lauro, Luigi AD - Division of Medical Oncology B, Regina Elena National Cancer Institute, Rome, Italy. pvici@ifo.it Y1 - 2011/04/12/ PY - 2011 DA - 2011 Apr 12 SP - 39 VL - 30 KW - liposomal doxorubicin KW - 0 KW - Polyethylene Glycols KW - 30IQX730WE KW - Epirubicin KW - 3Z8479ZZ5X KW - Vinblastine KW - 5V9KLZ54CY KW - Doxorubicin KW - 80168379AG KW - vinorelbine KW - Q6C979R91Y KW - Index Medicus KW - Disease-Free Survival KW - Doxorubicin -- analogs & derivatives KW - Soft Tissue Neoplasms -- mortality KW - Humans KW - Bone Neoplasms -- mortality KW - Aged KW - Soft Tissue Neoplasms -- drug therapy KW - Doxorubicin -- administration & dosage KW - Polyethylene Glycols -- administration & dosage KW - Soft Tissue Neoplasms -- secondary KW - Viscera -- pathology KW - Kaplan-Meier Estimate KW - Vinblastine -- analogs & derivatives KW - Prospective Studies KW - Neoplasm Recurrence, Local -- drug therapy KW - Adult KW - Bone Neoplasms -- drug therapy KW - Vinblastine -- administration & dosage KW - Middle Aged KW - Epirubicin -- administration & dosage KW - Bone Neoplasms -- secondary KW - Female KW - Neoplasm Recurrence, Local -- mortality KW - Alopecia -- chemically induced KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- mortality KW - Breast Neoplasms -- pathology KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863901927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+experimental+%26+clinical+cancer+research+%3A+CR&rft.atitle=A+multicenter+prospective+phase+II+randomized+trial+of+epirubicin%2Fvinorelbine+versus+pegylated+liposomal+doxorubicin%2Fvinorelbine+as+first-line+treatment+in+advanced+breast+cancer.+A+GOIM+study.&rft.au=Vici%2C+Patrizia%3BColucci%2C+Giuseppe%3BGiotta%2C+Francesco%3BSergi%2C+Domenico%3BFilippelli%2C+Gianfranco%3BPerri%2C+Pasquale%3BBotti%2C+Claudio%3BVizza%2C+Enrico%3BCarpino%2C+Armando%3BPizzuti%2C+Laura%3BLatorre%2C+Agnese%3BGiannarelli%2C+Diana%3BLopez%2C+Massimo%3BDi+Lauro%2C+Luigi&rft.aulast=Vici&rft.aufirst=Patrizia&rft.date=2011-04-12&rft.volume=30&rft.issue=&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+experimental+%26+clinical+cancer+research+%3A+CR&rft.issn=1756-9966&rft_id=info:doi/10.1186%2F1756-9966-30-39 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-01 N1 - Date created - 2011-04-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] Cochrane Database Syst Rev. 2010;(5):CD005006 [20464735] Ann Oncol. 2000 Aug;11(8):1029-33 [11038041] J Clin Oncol. 2001 Mar 1;19(5):1444-54 [11230490] Stat Med. 2001 Mar 30;20(6):859-66 [11252008] Eur J Cancer. 2001 Jun;37(9):1132-40 [11378344] Cancer. 2002 Jan 1;94(1):25-36 [11815957] J Clin Oncol. 2002 Jun 1;20(11):2689-94 [12039931] Oncology. 2002;63(1):23-30 [12187067] Ann Oncol. 2004 Mar;15(3):440-9 [14998846] J Clin Oncol. 2004 Jun 15;22(12):2313-20 [15197192] Ann Oncol. 2004 Oct;15(10):1527-34 [15367414] J Clin Oncol. 2004 Oct 1;22(19):3893-901 [15459210] Cochrane Database Syst Rev. 2004;(4):CD003367 [15495049] J Clin Oncol. 1988 Apr;6(4):679-88 [2895801] J Clin Oncol. 1988 Jun;6(6):976-82 [2897433] J Clin Oncol. 1993 Jul;11(7):1245-52 [8315421] J Clin Oncol. 1993 Jul;11(7):1253-63 [8315422] Ann Oncol. 1993 May;4(5):359-69 [8353070] J Clin Oncol. 1994 Sep;12(9):1764-70 [8083698] J Clin Oncol. 1994 Oct;12(10):2094-101 [7931479] Eur J Cancer. 1995 Dec;31A(13-14):2406-8 [8652277] Ann Oncol. 1997 Feb;8(2):155-62 [9093724] J Clin Oncol. 1998 Jan;16(1):86-92 [9440727] Cancer Res. 1998 Apr 1;58(7):1408-16 [9537241] Breast Cancer Res Treat. 1998 May;49(2):129-34 [9696395] Cancer. 1999 Mar 1;85(5):1091-7 [10091793] Ann Oncol. 1999 Aug;10(8):937-42 [10509155] Clin Breast Cancer. 2004 Dec;5(5):353-7 [15585072] J Clin Oncol. 2005 Mar 10;23(8):1760-75 [15755984] Anticancer Res. 2005 Mar-Apr;25(2B):1309-14 [15865083] Cancer Chemother Pharmacol. 2006 Dec;58(6):742-8 [16718470] Am J Clin Oncol. 2007 Apr;30(2):133-8 [17414461] Ann Oncol. 2007 Jun;18 Suppl 6:vi70-3 [17591837] Oncologist. 2007 Nov;12(11):1288-98 [18055848] Cancer Chemother Pharmacol. 2008 Jul;62(2):285-92 [17922275] Cancer Treat Rev. 2008 Aug;34(5):391-406 [18358614] Onkologie. 2009 Feb;32(1-2):18-24 [19209014] Cochrane Database Syst Rev. 2010;(3):CD005006 [20238335] J Clin Oncol. 2000 Jun;18(12):2385-94 [10856098] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1756-9966-30-39 ER - TY - JOUR T1 - Lack of PPAR alpha exacerbates lipopolysaccharide-induced liver toxicity through STAT1 inflammatory signaling and increased oxidative/nitrosative stress AN - 869579362; 14524898 AB - a-[ordm Activation of STAT1 and NF-I[ordmB inflammation signaling in LPS-exposed Ppara-null Mice. a-[ordm Elevation of pro-inflammatory cytokines and chemokines in LPS-exposed Ppara-null mice. a-[ordm Inhibition of anti-oxidant enzymes and mitochondrial complexes after LPS exposure. a-[ordm Increased lipid peroxidation and protein nitration in LPS-exposed Ppara-null mice. a-[ordm More severe LPS-induced acute liver damage in Ppara-null mice than WT mice. Peroxisome proliferator-activated receptor- alpha (PPAR alpha ) has been implicated in a potent anti-inflammatory activity. However, no information is available on whether PPAR alpha can affect signal transducers and activator of transcription proteins (STATs) in acute liver damage. Thus, this study was aimed to investigate the in vivo role of PPAR alpha in elevating STATs as well as oxidative/nitrosative stress in a model of lipopolysaccharide (LPS)-induced acute hepatic inflammatory injury. Using age-matched Ppara-null and wild-type (WT) mice, we demonstrate that the deletion of PPAR alpha aggravates LPS-mediated liver injury through activating STAT1 and NF-I[ordmB-p65 accompanied by increased levels of pro-inflammatory cytokines. Furthermore, the activities of key anti-oxidant enzymes and mitochondrial complexes were significantly decreased while lipid peroxidation and protein nitration were elevated in LPS-exposed Ppara-null mice compared to WT. These results indicate that PPAR alpha is important in preventing LPS-induced acute liver damage by regulating STAT1 inflammatory signaling pathways and oxidative/nitrosative stress. JF - Toxicology Letters AU - Yoo, Seong Ho AU - Park, Ogyi AU - Henderson, Lauren E AU - Abdelmegeed, Mohamed A AU - Moon, Kwan-Hoon AU - Song, Byoung-Joon AD - Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, United States, bj.song@nih.gov Y1 - 2011/04/10/ PY - 2011 DA - 2011 Apr 10 SP - 23 EP - 29 PB - Elsevier Science, Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland VL - 202 IS - 1 SN - 0378-4274, 0378-4274 KW - Environment Abstracts; Toxicology Abstracts KW - LPS KW - TLR KW - TNF alpha KW - NF-I[ordmB KW - MAPK KW - STAT KW - ALT KW - WT KW - SOD KW - H� MPO KW - TUNEL KW - MDA KW - CAT KW - GPx KW - TE buffer, 50mM KW - IL-6 KW - MCP-1 KW - IFN-I[sup3 KW - TNFR1 KW - ROS KW - 3-NT KW - PPAR alpha KW - Lipopolysaccharide KW - Acute liver damage KW - Cytokines KW - Oxidative/nitrosative stress KW - Chemokines KW - Peroxisome proliferator-activated receptor- alpha KW - Injuries KW - Lipids KW - Animal models KW - Mitochondria KW - Models KW - Lipopolysaccharides KW - Enzymes KW - Stress KW - Transcription KW - Mice KW - Toxicity KW - peroxidation KW - Lipid peroxidation KW - Inflammation KW - Stat1 protein KW - Nitration KW - Liver KW - Proteins KW - Antiinflammatory agents KW - Signal transduction KW - X 24370:Natural Toxins KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869579362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Lack+of+PPAR+alpha+exacerbates+lipopolysaccharide-induced+liver+toxicity+through+STAT1+inflammatory+signaling+and+increased+oxidative%2Fnitrosative+stress&rft.au=Yoo%2C+Seong+Ho%3BPark%2C+Ogyi%3BHenderson%2C+Lauren+E%3BAbdelmegeed%2C+Mohamed+A%3BMoon%2C+Kwan-Hoon%3BSong%2C+Byoung-Joon&rft.aulast=Yoo&rft.aufirst=Seong&rft.date=2011-04-10&rft.volume=202&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2011.01.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Chemokines; Peroxisome proliferator-activated receptor- alpha; Injuries; Animal models; Transcription; Stress; Enzymes; Mitochondria; Toxicity; Lipid peroxidation; Models; Inflammation; Stat1 protein; Liver; Nitration; Cytokines; Lipopolysaccharides; Antiinflammatory agents; Signal transduction; Lipids; Proteins; Mice; peroxidation DO - http://dx.doi.org/10.1016/j.toxlet.2011.01.013 ER - TY - CPAPER T1 - Janus kinases: role in cytokine signaling and as therapeutic targets T2 - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AN - 1313037344; 6086033 JF - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AU - O'Shea, John Y1 - 2011/04/09/ PY - 2011 DA - 2011 Apr 09 KW - Cytokines KW - Janus kinase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313037344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.atitle=Janus+kinases%3A+role+in+cytokine+signaling+and+as+therapeutic+targets&rft.au=O%27Shea%2C+John&rft.aulast=O%27Shea&rft.aufirst=John&rft.date=2011-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.aspet.org/EB2011/Scientific_Program_Index/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Inflammation and cardiovascular disease: RGS in bronchial smooth muscle/asthma T2 - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AN - 1313036651; 6086052 JF - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AU - Druey, K Y1 - 2011/04/09/ PY - 2011 DA - 2011 Apr 09 KW - Respiratory diseases KW - Asthma KW - Smooth muscle KW - Cardiovascular diseases KW - Inflammation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313036651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.atitle=Inflammation+and+cardiovascular+disease%3A+RGS+in+bronchial+smooth+muscle%2Fasthma&rft.au=Druey%2C+K&rft.aulast=Druey&rft.aufirst=K&rft.date=2011-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.aspet.org/EB2011/Scientific_Program_Index/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Epoxyeicosanoid metabolism T2 - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AN - 1313014838; 6085982 JF - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AU - Spector, Art Y1 - 2011/04/09/ PY - 2011 DA - 2011 Apr 09 KW - Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313014838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.atitle=Epoxyeicosanoid+metabolism&rft.au=Spector%2C+Art&rft.aulast=Spector&rft.aufirst=Art&rft.date=2011-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.aspet.org/EB2011/Scientific_Program_Index/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Systems biology and drug development T2 - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AN - 1312994944; 6085935 JF - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AU - Berg, Jeremy Y1 - 2011/04/09/ PY - 2011 DA - 2011 Apr 09 KW - Drug development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312994944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.atitle=Systems+biology+and+drug+development&rft.au=Berg%2C+Jeremy&rft.aulast=Berg&rft.aufirst=Jeremy&rft.date=2011-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.aspet.org/EB2011/Scientific_Program_Index/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Selective mutations in estrogen receptor alpha D-domain alters nuclear translocation and non-estrogen response element gene regulatory mechanisms. AN - 860184793; 21285458 AB - The three main mechanisms of ERα action are: 1) nuclear, genomic, direct DNA binding, 2) nuclear, genomic, "tethered"-mediated, protein-protein interactions, and 3) non-nuclear, non-genomic, rapid action responses. Reports suggest the D-domain or hinge region of ERα plays an important role in mechanisms 1 and 2 above. Studies demonstrating the functionality of the ERα hinge region have resected the full D-domain; therefore, site directed mutations were made to attribute precise sequence functionality to this domain. This study focuses on the characterization and properties of three novel site directed ERα- D-domain mutants. The Hinge 1 (H1) ERα mutant has disrupted nuclear localization, can no longer perform tethered mediated responses and has lost interaction with c-Jun, but retains estrogen response element (ERE)-mediated functions as demonstrated by confocal microscopy, reporter assays, endogenous gene expression and co-immunoprecipitation. The H2 ERα mutant is non-nuclear, but translocates to the nucleus with estradiol (E2) treatment and maintains ERE-mediated functionality. The H2+NES ERα mutant does not maintain nuclear translocation with hormone binding, no longer activates ERE-target genes, functions in ERE- or tethered-mediated luciferase assays, but does retain the non-genomic, non-nuclear, rapid action response. These studies reveal the sequence(s) in the ERα hinge region that are involved in tethered-mediated actions as well as nuclear localization and attribute important functionality to this region of the receptor. In addition, the properties of these ERα mutants will allow future studies to further dissect and characterize the three main ERα mechanisms of action and determine the mechanistic role each action has in estrogen hormone regulation. JF - The Journal of biological chemistry AU - Burns, Katherine A AU - Li, Yin AU - Arao, Yukitomo AU - Petrovich, Robert M AU - Korach, Kenneth S AD - Receptor Biology, Laboratory of Reproductive and Developmental Toxicology, Protein Expression Core Facility, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2011/04/08/ PY - 2011 DA - 2011 Apr 08 SP - 12640 EP - 12649 VL - 286 IS - 14 KW - Estrogen Receptor alpha KW - 0 KW - Nuclear Receptor Coactivator 2 KW - Proto-Oncogene Proteins c-jun KW - estrogen receptor alpha, human KW - Index Medicus KW - Microscopy, Confocal KW - HeLa Cells KW - Humans KW - Immunoprecipitation KW - Nuclear Receptor Coactivator 2 -- metabolism KW - Proto-Oncogene Proteins c-jun -- metabolism KW - Polymerase Chain Reaction KW - Protein Binding -- physiology KW - Nuclear Receptor Coactivator 2 -- genetics KW - Proto-Oncogene Proteins c-jun -- genetics KW - Protein Binding -- genetics KW - Mutation KW - Cell Line KW - Protein Transport KW - Estrogen Receptor alpha -- genetics KW - Cell Nucleus -- metabolism KW - Response Elements -- genetics KW - Estrogen Receptor alpha -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860184793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Selective+mutations+in+estrogen+receptor+alpha+D-domain+alters+nuclear+translocation+and+non-estrogen+response+element+gene+regulatory+mechanisms.&rft.au=Burns%2C+Katherine+A%3BLi%2C+Yin%3BArao%2C+Yukitomo%3BPetrovich%2C+Robert+M%3BKorach%2C+Kenneth+S&rft.aulast=Burns&rft.aufirst=Katherine&rft.date=2011-04-08&rft.volume=286&rft.issue=14&rft.spage=12640&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M110.187773 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-19 N1 - Date created - 2011-04-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Jul 7;275(27):20853-60 [10779504] J Steroid Biochem Mol Biol. 2000 Nov 30;74(5):311-7 [11162939] J Biol Chem. 2001 Apr 27;276(17):13615-21 [11278408] Vitam Horm. 2001;62:231-52 [11345900] J Biol Chem. 2001 May 25;276(21):18375-83 [11279135] J Biol Chem. 2001 Sep 28;276(39):36361-9 [11477071] Biochem Biophys Res Commun. 2002 Jun 28;294(5):926-33 [12074565] Mol Cell Biol. 2002 Oct;22(19):6871-82 [12215544] Mol Endocrinol. 2002 Oct;16(10):2188-201 [12351685] Nucleic Acids Res. 2001 May 1;29(9):e45 [11328886] Mol Cell Biol. 2003 Mar;23(5):1633-46 [12588983] J Biol Chem. 2003 Apr 4;278(14):12255-62 [12547836] J Neurochem. 2004 May;89(3):674-84 [15086524] Mol Endocrinol. 2004 Aug;18(8):1887-905 [15143151] Protein Eng Des Sel. 2004 Jun;17(6):527-36 [15314210] EMBO J. 1988 Nov;7(11):3385-8 [3145193] Cell Regul. 1990 Feb;1(3):291-9 [2100202] EMBO J. 1992 Oct;11(10):3681-94 [1327748] Nucleic Acids Res. 1993 Mar 11;21(5):1125-32 [8385312] Endocr Rev. 1994 Jun;15(3):391-407 [8076589] J Biol Chem. 1995 May 12;270(19):11502-13 [7744790] Mol Endocrinol. 1995 Apr;9(4):443-56 [7659088] Cell. 1995 Dec 15;83(6):835-9 [8521507] Mol Endocrinol. 1995 Nov;9(11):1441-54 [8584021] J Cell Biol. 1996 Sep;134(6):1365-73 [8830767] Nature. 1997 Jun 12;387(6634):733-6 [9192902] Mol Endocrinol. 1999 Feb;13(2):307-19 [9973260] Steroids. 1999 May;64(5):310-9 [10406480] Mol Endocrinol. 1999 Oct;13(10):1672-85 [10517669] Mol Biol Cell. 2005 Jan;16(1):231-7 [15496458] Mol Endocrinol. 2005 Feb;19(2):277-89 [15486047] Biochemistry. 2005 Feb 22;44(7):2678-85 [15709781] Mol Endocrinol. 2005 Jun;19(6):1606-17 [15831524] Mol Endocrinol. 2005 Aug;19(8):1951-9 [15705661] Trends Endocrinol Metab. 2005 Oct;16(8):347-53 [16126407] Mol Endocrinol. 2005 Nov;19(11):2671-84 [15961505] Mol Endocrinol. 2006 Mar;20(3):491-502 [16306086] Mol Endocrinol. 2006 Jul;20(7):1479-93 [16497729] J Biol Chem. 2007 Apr 13;282(15):10963-71 [17314103] J Biol Chem. 2007 Aug 3;282(31):22278-88 [17535799] J Steroid Biochem Mol Biol. 2007 Aug-Sep;106(1-5):102-10 [17616457] Endocr Rev. 2007 Dec;28(7):726-41 [17916740] Biochem Biophys Res Commun. 2008 Jun 20;371(1):44-9 [18407829] Mol Cell. 2008 May 9;30(3):336-47 [18471979] Mol Cell Endocrinol. 2008 Aug 13;290(1-2):24-30 [18534740] Mol Endocrinol. 2008 Sep;22(9):2116-27 [18617595] J Proteome Res. 2008 Oct;7(10):4538-45 [18781795] Mol Endocrinol. 2008 Nov;22(11):2393-406 [18818283] J Mol Biol. 2008 Dec 5;384(1):22-30 [18822299] Endocr Relat Cancer. 2009 Jun;16(2):319-23 [19208734] Environ Health Perspect. 2009 Jul;117(7):1155-61 [19654927] Mol Endocrinol. 2009 Dec;23(12):2111-6 [19812388] J Biol Chem. 2010 Jan 22;285(4):2676-85 [19920132] J Cell Sci. 2010 Apr 15;123(Pt 8):1253-61 [20332105] Cell Mol Life Sci. 2010 Jun;67(11):1919-27 [20186458] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M110.187773 ER - TY - JOUR T1 - Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in Poland AN - 1093468082; 16209934 AB - Studies suggest that high circulating levels of prolactin increase breast cancer risk. It is unclear if genetic variations in prolactin (PRL) or prolactin receptor (PRLR) genes also play a role. Thus, we examined the relationship between single nucleotide polymorphisms (SNPs) in PRL and PRLR, serum prolactin levels and breast cancer risk in a population-based case-control study. We genotyped 8 PRL and 20 PRLR tag SNPs in 1965 breast cancer cases and 2229 matched controls, aged 20-74, and living in Warsaw or Lodz, Poland. Serum prolactin levels were measured by immunoassay in a subset of 773 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) for genotype associations with breast cancer risk were estimated using unconditional logistic regression, adjusted for age and study site. Geometric mean prolactin levels were estimated using linear regression models adjusted for age, study site, blood collection time, and menstrual cycle day (premenopausal women). Three SNPs were associated with breast cancer risk: in premenopausal women, PRLR rs249537 (T vs. C per-allele OR 1.39, 95% CI 1.07 - 1.80, P = 0.01); and in postmenopausal women, PRLR rs7718468 (C vs. T per-allele OR 1.16, 95% CI 1.03 - 1.30, P = 0.01) and PRLR rs13436213 (A vs. G per-allele OR 1.13 95% CI 1.01 - 1.26, P = 0.04). However, mean serum prolactin levels for these SNPs did not vary by genotype (P-trend > 0.05). Other SNPs were associated with serum prolactin levels: PRLR rs62355518 (P-trend = 0.01), PRLR rs10941235 (P-trend = 0.01), PRLR rs1610218 (P-trend = 0.01), PRLR rs34024951 (P-trend = 0.02), and PRLR rs9292575 (P-trend = 0.03) in premenopausal controls and PRL rs849872 (P-trend = 0.01) in postmenopausal controls. Our data provide limited support for an association between common variations in PRLR and breast cancer risk. Altered serum prolactin levels were not associated with breast cancer risk-associated variants, suggesting that common genetic variation is not a strong predictor of prolactin-associated breast cancer risk in this population. JF - Breast Cancer Research AU - Nyante, Sarah J AU - Faupel-Badger, Jessica M AU - Sherman, Mark E AU - Pfeiffer, Ruth M AU - Gaudet, Mia M AU - Falk, Roni T AU - Andaya, Abegail A AU - Lissowska, Jolanta AU - Brinton, Louise A AU - Peplonska, Beata AU - Vonderhaar, Barbara K AU - Chanock, Stephen AU - Garcia-Closas, Montserrat AU - Figueroa, Jonine D AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, USA, sarah.nyante@nih.gov Y1 - 2011/04/06/ PY - 2011 DA - 2011 Apr 06 SP - R42 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 13 IS - 2 SN - 1465-5411, 1465-5411 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - Breast cancer KW - Cancer KW - Genetic diversity KW - Genotypes KW - Immunoassays KW - Post-menopause KW - Poland KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1093468082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+Cancer+Research&rft.atitle=Genetic+variation+in+PRL+and+PRLR%2C+and+relationships+with+serum+prolactin+levels+and+breast+cancer+risk%3A+results+from+a+population-based+case-control+study+in+Poland&rft.au=Nyante%2C+Sarah+J%3BFaupel-Badger%2C+Jessica+M%3BSherman%2C+Mark+E%3BPfeiffer%2C+Ruth+M%3BGaudet%2C+Mia+M%3BFalk%2C+Roni+T%3BAndaya%2C+Abegail+A%3BLissowska%2C+Jolanta%3BBrinton%2C+Louise+A%3BPeplonska%2C+Beata%3BVonderhaar%2C+Barbara+K%3BChanock%2C+Stephen%3BGarcia-Closas%2C+Montserrat%3BFigueroa%2C+Jonine+D&rft.aulast=Nyante&rft.aufirst=Sarah&rft.date=2011-04-06&rft.volume=13&rft.issue=2&rft.spage=R42&rft.isbn=&rft.btitle=&rft.title=Breast+Cancer+Research&rft.issn=14655411&rft_id=info:doi/10.1186%2Fbcr2864 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Age; Post-menopause; Genetic diversity; Breast cancer; Genotypes; Immunoassays; Cancer; Poland DO - http://dx.doi.org/10.1186/bcr2864 ER - TY - JOUR T1 - Occupational cancer in developed countries AN - 893264044; 14659291 AB - Studies of occupational exposures have made major contributions to our understanding of human carcinogenesis. About one third of the factors identified as definite or probable human carcinogens were first investigated in the workplace and these exposures exact a considerable toll on working populations. There are many additional workplace exposures that are suspect carcinogens that require further evaluation to ensure a safe work environment. Information from occupational investigations is also relevant to the general population because many occupational exposures can be found outside the workplace. Much of our understanding about occupational cancer has been obtained from studies largely composed of white men in developed countries. The movement of industry from developed to developing countries underscores the need for future investigations to include more diverse populations. JF - Environmental Health AU - Blair, Aaron AU - Marrett, Loraine AU - Beane Freeman, Laura AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA Y1 - 2011/04/05/ PY - 2011 DA - 2011 Apr 05 SP - S9 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 10 IS - 1 KW - Health & Safety Science Abstracts KW - Cancer KW - Carcinogenesis KW - Carcinogens KW - Developing countries KW - Occupational exposure KW - developed countries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893264044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health&rft.atitle=Occupational+cancer+in+developed+countries&rft.au=Blair%2C+Aaron%3BMarrett%2C+Loraine%3BBeane+Freeman%2C+Laura&rft.aulast=Blair&rft.aufirst=Aaron&rft.date=2011-04-05&rft.volume=10&rft.issue=1&rft.spage=S9&rft.isbn=&rft.btitle=&rft.title=Environmental+Health&rft.issn=1476-069X&rft_id=info:doi/10.1186%2F1476-069X-10-S1-S9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - Carcinogenesis; Carcinogens; Developing countries; Occupational exposure; Cancer; developed countries DO - http://dx.doi.org/10.1186/1476-069X-10-S1-S9 ER - TY - JOUR T1 - High recombination rates and hotspots in a Plasmodium falciparum genetic cross AN - 920806372; 16210214 AB - The human malaria parasite Plasmodium falciparum survives pressures from the host immune system and antimalarial drugs by modifying its genome. Genetic recombination and nucleotide substitution are the two major mechanisms that the parasite employs to generate genome diversity. A better understanding of these mechanisms may provide important information for studying parasite evolution, immune evasion and drug resistance. Here, we used a high-density tiling array to estimate the genetic recombination rate among 32 progeny of a P. falciparum genetic cross (7G8 GB4). We detected 638 recombination events and constructed a high-resolution genetic map. Comparing genetic and physical maps, we obtained an overall recombination rate of 9.6 kb per centimorgan and identified 54 candidate recombination hotspots. Similar to centromeres in other organisms, the sequences of P. falciparum centromeres are found in chromosome regions largely devoid of recombination activity. Motifs enriched in hotspots were also identified, including a 12-bp G/C-rich motif with 3-bp periodicity that may interact with a protein containing 11 predicted zinc finger arrays. These results show that the P. falciparum genome has a high recombination rate, although it also follows the overall rule of meiosis in eukaryotes with an average of approximately one crossover per chromosome per meiosis. GC-rich repetitive motifs identified in the hotspot sequences may play a role in the high recombination rate observed. The lack of recombination activity in centromeric regions is consistent with the observations of reduced recombination near the centromeres of other organisms. JF - Genome Biology AU - Jiang, Hongying AU - Li, Na AU - Gopalan, Vivek AU - Zilversmit, Martine M AU - Varma, Sudhir AU - Nagarajan, Vijayaraj AU - Li, Jian AU - Mu, Jianbing AU - Hayton, Karen AU - Henschen, Bruce AU - Yi, Ming AU - Stephens, Robert AU - McVean, Gilean AU - Awadalla, Philip AU - Wellems, Thomas E AU - Su, Xin-zhuan AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA, hojiang@niaid.nih.gov Y1 - 2011/04/04/ PY - 2011 DA - 2011 Apr 04 SP - R33 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 12 IS - 4 SN - 1465-6906, 1465-6906 KW - Biochemistry Abstracts 2: Nucleic Acids; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; Genetics Abstracts KW - Genomes KW - Parasites KW - Human diseases KW - Hot spots KW - Drug resistance KW - Immune system KW - Nucleotide sequence KW - Zinc finger proteins KW - Malaria KW - Immunosuppressive agents KW - Centromeres KW - Public health KW - Recombination KW - Chromosomes KW - Antimalarial agents KW - Pressure KW - Plasmodium falciparum KW - Nucleotides KW - Meiosis KW - DNA KW - Periodicity KW - Genetic crosses KW - Evolution KW - Gene mapping KW - Q1 08484:Species interactions: parasites and diseases KW - N 14845:Miscellaneous KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920806372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+Biology&rft.atitle=High+recombination+rates+and+hotspots+in+a+Plasmodium+falciparum+genetic+cross&rft.au=Jiang%2C+Hongying%3BLi%2C+Na%3BGopalan%2C+Vivek%3BZilversmit%2C+Martine+M%3BVarma%2C+Sudhir%3BNagarajan%2C+Vijayaraj%3BLi%2C+Jian%3BMu%2C+Jianbing%3BHayton%2C+Karen%3BHenschen%2C+Bruce%3BYi%2C+Ming%3BStephens%2C+Robert%3BMcVean%2C+Gilean%3BAwadalla%2C+Philip%3BWellems%2C+Thomas+E%3BSu%2C+Xin-zhuan&rft.aulast=Jiang&rft.aufirst=Hongying&rft.date=2011-04-04&rft.volume=12&rft.issue=4&rft.spage=R33&rft.isbn=&rft.btitle=&rft.title=Genome+Biology&rft.issn=14656906&rft_id=info:doi/10.1186%2Fgb-2011-12-4-r33 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Genomes; Parasites; Recombination; Human diseases; Hot spots; Nucleotide sequence; DNA; Malaria; Public health; Immune system; Drug resistance; Zinc finger proteins; Immunosuppressive agents; Nucleotides; Centromeres; Chromosomes; Meiosis; Antimalarial agents; Periodicity; Pressure; Genetic crosses; Evolution; Gene mapping; Plasmodium falciparum DO - http://dx.doi.org/10.1186/gb-2011-12-4-r33 ER - TY - JOUR T1 - Micronucleus formation and DNA damage in buccal epithelial cells of Indian street boys addicted to gasp 'Golden glue' AN - 867744420; 14610077 AB - Genotoxicity of glue sniffing/huffing and tobacco use has been examined in 302 street boys (median age 13 years) and 50 age-matched control school boys who were neither tobacco nor glue users. All the street boys were tobacco users. In addition, 155 were addicted to gasp an industrial adhesive popularly known as 'Golden glue'. Micronucleus (MN) frequency was determined as a measure of chromosomal breakage in exfoliated buccal epithelial cells (BECs) and DNA double strand breaks were quantitatively assessed by counting gamma -H2AX foci using immunofluorescence microscopy. Micronucleated cell frequencies (MCFs) in BEC of glue non-addicted (only tobacco) and addicted (tobacco plus glue) street boys were 1.87 plus or minus 1.06 degree and 4.04 plus or minus 2.55 degree respectively, which were significantly higher than that of control (0.32 plus or minus 0.11 degree , p <0.0001). Similarly, the numbers gamma -H2AX foci in nuclei of BEC were 2.3- and 5.2-times more than control in glue non-addicted and addicted street boys respectively (p <0.0001). Spearman's rank correlation revealed a strong positive association between years of glue addiction with MCFs and gamma -H2AX foci numbers, and the association between glue addiction and chromosomal and DNA damage remained positive and significant after controlling income, spending on addiction and loss of appetite as potential confounders in multivariate logistic regression analysis. Thus, addiction to tobacco among the street children in India is associated with chromosomal and DNA damage in BECs and the severity of these changes is significantly increased by the habit of sniffing/huffing of industrial glue. JF - Mutation Research/Genetic Toxicology and Environmental Mutagenesis AU - Mondal, Nandan Kumar AU - Ghosh, Sreenita AU - Ray, Manas Ranjan AD - Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata, West Bengal 700026, India, nandan_gm@yahoo.com Y1 - 2011/04/03/ PY - 2011 DA - 2011 Apr 03 SP - 178 EP - 183 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 721 IS - 2 SN - 1383-5718, 1383-5718 KW - Biochemistry Abstracts 2: Nucleic Acids; Pollution Abstracts; Genetics Abstracts; Toxicology Abstracts KW - Epithelial cells KW - Age KW - Appetite KW - India KW - Mutagenesis KW - schools KW - income KW - Regression analysis KW - Tobacco KW - Addiction KW - Nuclei KW - Drug addiction KW - Adhesives KW - Manganese KW - Genotoxicity KW - Enumeration KW - Immunofluorescence KW - Children KW - DNA damage KW - Microscopy KW - DNA KW - Mutation KW - X 24380:Social Poisons & Drug Abuse KW - N 14820:DNA Metabolism & Structure KW - G 07710:Chemical Mutagenesis & Radiation KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867744420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=Micronucleus+formation+and+DNA+damage+in+buccal+epithelial+cells+of+Indian+street+boys+addicted+to+gasp+%27Golden+glue%27&rft.au=Mondal%2C+Nandan+Kumar%3BGhosh%2C+Sreenita%3BRay%2C+Manas+Ranjan&rft.aulast=Mondal&rft.aufirst=Nandan&rft.date=2011-04-03&rft.volume=721&rft.issue=2&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2011.01.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Genotoxicity; Immunofluorescence; Enumeration; Appetite; Children; Mutagenesis; DNA damage; Microscopy; Tobacco; Regression analysis; Addiction; Adhesives; Drug addiction; Nuclei; Manganese; Age; schools; income; DNA; Mutation; India DO - http://dx.doi.org/10.1016/j.mrgentox.2011.01.011 ER - TY - CPAPER T1 - Role of Fc?RIIB in metastatic melanoma and rhabdomyosarcoma T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313096569; 6097020 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Lu, Andrew AU - Yu, Yanlin AU - Merlino, Glenn Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Melanoma KW - Rhabdomyosarcoma KW - Metastases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313096569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Role+of+Fc%3FRIIB+in+metastatic+melanoma+and+rhabdomyosarcoma&rft.au=Lu%2C+Andrew%3BYu%2C+Yanlin%3BMerlino%2C+Glenn&rft.aulast=Lu&rft.aufirst=Andrew&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Rapamycin prolongs overall survival and progression-free survival in a mouse model of lung cancer in never smokers resistant to erlotinib T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313090188; 6097276 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Kawabata, Shigeru AU - Mercado, Jose AU - Hollander, M AU - Wilson, III, Willie AU - Regales, Lucia AU - Pao, William AU - Janne, Pasi AU - Wong, Kwok-Kin AU - Dennis, Phillip Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Survival KW - Lung cancer KW - Animal models KW - Rapamycin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313090188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Rapamycin+prolongs+overall+survival+and+progression-free+survival+in+a+mouse+model+of+lung+cancer+in+never+smokers+resistant+to+erlotinib&rft.au=Kawabata%2C+Shigeru%3BMercado%2C+Jose%3BHollander%2C+M%3BWilson%2C+III%2C+Willie%3BRegales%2C+Lucia%3BPao%2C+William%3BJanne%2C+Pasi%3BWong%2C+Kwok-Kin%3BDennis%2C+Phillip&rft.aulast=Kawabata&rft.aufirst=Shigeru&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Molecular stratification for ovarian cancer treatment: new trial designs needed? T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313089084; 6097170 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Kohn, Elise Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Ovarian carcinoma KW - Stratification KW - Ovarian cancer KW - Ovaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313089084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Molecular+stratification+for+ovarian+cancer+treatment%3A+new+trial+designs+needed%3F&rft.au=Kohn%2C+Elise&rft.aulast=Kohn&rft.aufirst=Elise&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - From beast to best clinical outcome: Development of guiding preclinical strategies T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313088561; 6097140 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Van Dyke, Terry Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Cancer KW - Stem cells KW - Oncology KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313088561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=From+beast+to+best+clinical+outcome%3A+Development+of+guiding+preclinical+strategies&rft.au=Van+Dyke%2C+Terry&rft.aulast=Van+Dyke&rft.aufirst=Terry&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Menin-mediated regulation of pancreatic beta-cell differentiation factors T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313087651; 6096758 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Shi, Kerong AU - Parekh, Vaishali AU - Roy, Swarnava AU - Agarwal, Sunita Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Differentiation KW - Pancreas UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313087651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Menin-mediated+regulation+of+pancreatic+beta-cell+differentiation+factors&rft.au=Shi%2C+Kerong%3BParekh%2C+Vaishali%3BRoy%2C+Swarnava%3BAgarwal%2C+Sunita&rft.aulast=Shi&rft.aufirst=Kerong&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Assessment of exposure to potential lung carcinogens in Xuanwei and Fuyuan, China: Particulate exposure from cooking and heating stoves T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313086740; 6096695 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Hu, Wei AU - Reiss, Boris AU - Rothman, Nat AU - Morales, Kathleen AU - Xu, Jun AU - Bassig, Bryan AU - Hosgood, III, Dean AU - Tian, Linwei AU - He, Xinzhou AU - Shen, Min AU - Engel, Lawrence AU - Zhang, Linlin AU - Wu, Guoping AU - Wei, Fusheng AU - Lan, Qing AU - Vermeulen, Roel Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - China, People's Rep. KW - Cooking KW - Particulates KW - Lung KW - Carcinogens UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313086740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Assessment+of+exposure+to+potential+lung+carcinogens+in+Xuanwei+and+Fuyuan%2C+China%3A+Particulate+exposure+from+cooking+and+heating+stoves&rft.au=Hu%2C+Wei%3BReiss%2C+Boris%3BRothman%2C+Nat%3BMorales%2C+Kathleen%3BXu%2C+Jun%3BBassig%2C+Bryan%3BHosgood%2C+III%2C+Dean%3BTian%2C+Linwei%3BHe%2C+Xinzhou%3BShen%2C+Min%3BEngel%2C+Lawrence%3BZhang%2C+Linlin%3BWu%2C+Guoping%3BWei%2C+Fusheng%3BLan%2C+Qing%3BVermeulen%2C+Roel&rft.aulast=Hu&rft.aufirst=Wei&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Public health impact of occupational carcinogens exposure and lung cancer T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313086680; 6096693 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - De Matteis, Sara AU - Consonni, Dario AU - Lubin, Jay AU - Wacholder, Sholom AU - Tucker, Margaret AU - Peters, Susan AU - Vermeulen, Roel AU - Kromhout, Hans AU - Bertazzi, Pier AU - Caporaso, Neil AU - Pesatori, Angela AU - Landi, Maria Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Public health KW - Carcinogens KW - Lung cancer KW - Occupational exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313086680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Public+health+impact+of+occupational+carcinogens+exposure+and+lung+cancer&rft.au=De+Matteis%2C+Sara%3BConsonni%2C+Dario%3BLubin%2C+Jay%3BWacholder%2C+Sholom%3BTucker%2C+Margaret%3BPeters%2C+Susan%3BVermeulen%2C+Roel%3BKromhout%2C+Hans%3BBertazzi%2C+Pier%3BCaporaso%2C+Neil%3BPesatori%2C+Angela%3BLandi%2C+Maria&rft.aulast=De+Matteis&rft.aufirst=Sara&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Insulin-like growth factor 1 receptor antibody induces rhabdomyosarcoma cell death via a process involving AKT and Bcl-xL T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313079617; 6095583 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Mayeenuddin, Linnia AU - Yu, Yunkai AU - Kang, Zhigang AU - Helman, Lee AU - Cao, Liang Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Growth factors KW - Mortality KW - Cell death KW - Rhabdomyosarcoma KW - Antibodies KW - Insulin-like growth factors KW - AKT protein KW - Bcl-x protein KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313079617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Insulin-like+growth+factor+1+receptor+antibody+induces+rhabdomyosarcoma+cell+death+via+a+process+involving+AKT+and+Bcl-xL&rft.au=Mayeenuddin%2C+Linnia%3BYu%2C+Yunkai%3BKang%2C+Zhigang%3BHelman%2C+Lee%3BCao%2C+Liang&rft.aulast=Mayeenuddin&rft.aufirst=Linnia&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A Comparative Approach to Improve Our Understanding of Metastasis Biology and Therapy T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313079108; 6095162 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Khanna, Chand Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Metastases KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313079108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=A+Comparative+Approach+to+Improve+Our+Understanding+of+Metastasis+Biology+and+Therapy&rft.au=Khanna%2C+Chand&rft.aulast=Khanna&rft.aufirst=Chand&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The DNA double-strand break repair genes BARD1 and RAD51 as molecular targets for brain metastases from breast cancer T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313068774; 6097023 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Woditschka, Stephan AU - Palmieri, Diane AU - Flores, Natasha AU - Sledge, Jr., George AU - Badve, Sunil AU - Steeg, Patricia Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Brain KW - Breast cancer KW - DNA damage KW - double-strand break repair KW - Metastases KW - DNA repair UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313068774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+DNA+double-strand+break+repair+genes+BARD1+and+RAD51+as+molecular+targets+for+brain+metastases+from+breast+cancer&rft.au=Woditschka%2C+Stephan%3BPalmieri%2C+Diane%3BFlores%2C+Natasha%3BSledge%2C+Jr.%2C+George%3BBadve%2C+Sunil%3BSteeg%2C+Patricia&rft.aulast=Woditschka&rft.aufirst=Stephan&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - LPA1 regulated pathways that mediate breast cancer dormancy in the liver and lung T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313068405; 6096854 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Nakayama, Joji AU - Marshall, Jean-Claude AU - Murone, Maximilien AU - Steeg, Patricia Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Lung KW - Breast cancer KW - Liver KW - Dormancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313068405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=LPA1+regulated+pathways+that+mediate+breast+cancer+dormancy+in+the+liver+and+lung&rft.au=Nakayama%2C+Joji%3BMarshall%2C+Jean-Claude%3BMurone%2C+Maximilien%3BSteeg%2C+Patricia&rft.aulast=Nakayama&rft.aufirst=Joji&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Development of a prognostic multigene classifier for squamous cell carcinomas of the larynx T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313068270; 6095282 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Mirisola, Valentina AU - Pfeffer, Ulrich AU - Mora, Renzo AU - Esposito, Alessia AU - Guastini, Luca AU - Amaro, Adriana AU - Tabacchiera, Flavia AU - Paleari, Laura AU - Angelini, Giovanna AU - Dellepiane, Massimo AU - Salami, Angelo Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Larynx KW - squamous cell carcinoma KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313068270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Development+of+a+prognostic+multigene+classifier+for+squamous+cell+carcinomas+of+the+larynx&rft.au=Mirisola%2C+Valentina%3BPfeffer%2C+Ulrich%3BMora%2C+Renzo%3BEsposito%2C+Alessia%3BGuastini%2C+Luca%3BAmaro%2C+Adriana%3BTabacchiera%2C+Flavia%3BPaleari%2C+Laura%3BAngelini%2C+Giovanna%3BDellepiane%2C+Massimo%3BSalami%2C+Angelo&rft.aulast=Mirisola&rft.aufirst=Valentina&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - TARGET initiative overview T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313066857; 6097565 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Smith, Malcolm Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313066857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=TARGET+initiative+overview&rft.au=Smith%2C+Malcolm&rft.aulast=Smith&rft.aufirst=Malcolm&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Knockout mouse models for sirtuins: Genome integrity, metabolism, and cancer T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313061871; 6097135 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Deng, Chuxia AU - Kim, Hyun-Seok AU - Vassilopoulos, Athanassios AU - Wang, Rui-Hong AU - Lahusen, Tyler AU - Xiao, Zhen AU - Xu, Xiaoling AU - Li, Cuiling AU - Veenstra, Timothy AU - Ji, Junfang AU - Wang, Xin-Wei AU - Park, Seong-Hoon AU - Gius, David Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Cancer KW - Metabolism KW - Animal models KW - Genomes KW - Sirtuins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313061871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Knockout+mouse+models+for+sirtuins%3A+Genome+integrity%2C+metabolism%2C+and+cancer&rft.au=Deng%2C+Chuxia%3BKim%2C+Hyun-Seok%3BVassilopoulos%2C+Athanassios%3BWang%2C+Rui-Hong%3BLahusen%2C+Tyler%3BXiao%2C+Zhen%3BXu%2C+Xiaoling%3BLi%2C+Cuiling%3BVeenstra%2C+Timothy%3BJi%2C+Junfang%3BWang%2C+Xin-Wei%3BPark%2C+Seong-Hoon%3BGius%2C+David&rft.aulast=Deng&rft.aufirst=Chuxia&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The Cdk5 activator p39 specifically links muskelin to myosin and regulates stress fiber organization and contraction T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313060891; 6096477 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Tripathi, Brajendra AU - Lowy, Douglas AU - Zelenka, Peggy Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Stress KW - Fibers KW - Myosin KW - Cyclin-dependent kinase 5 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313060891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+Cdk5+activator+p39+specifically+links+muskelin+to+myosin+and+regulates+stress+fiber+organization+and+contraction&rft.au=Tripathi%2C+Brajendra%3BLowy%2C+Douglas%3BZelenka%2C+Peggy&rft.aulast=Tripathi&rft.aufirst=Brajendra&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Cell death pathway activation during monocytic / macrophagic differentiation of hematopoietic tumor cell lines T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313059462; 6095870 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - de Sellos, Joao AU - Caetano, Mauricio AU - Carvalho, Erika AU - Amarante-Mendes, Gustavo AU - Ferreira, Carlos AU - Sternberg, Cinthya Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Tumors KW - Mortality KW - Hemopoiesis KW - Cell death KW - Differentiation KW - Tumor cell lines KW - Monocytes KW - Cell activation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313059462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Cell+death+pathway+activation+during+monocytic+%2F+macrophagic+differentiation+of+hematopoietic+tumor+cell+lines&rft.au=de+Sellos%2C+Joao%3BCaetano%2C+Mauricio%3BCarvalho%2C+Erika%3BAmarante-Mendes%2C+Gustavo%3BFerreira%2C+Carlos%3BSternberg%2C+Cinthya&rft.aulast=de+Sellos&rft.aufirst=Joao&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - New Directions in Cancer Research T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313057129; 6095173 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Varmus, Harold Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313057129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=New+Directions+in+Cancer+Research&rft.au=Varmus%2C+Harold&rft.aulast=Varmus&rft.aufirst=Harold&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Notch pathway mediates post-treatment repopulation of lung squamous cell carcinoma cells T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313052906; 6096658 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Day, Chi-Ping AU - Esposito, Dominic AU - Mahesh, Cynthia AU - Merlino, Glenn Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Lung KW - Repopulation KW - Notch protein KW - squamous cell carcinoma KW - Lung carcinoma KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313052906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Notch+pathway+mediates+post-treatment+repopulation+of+lung+squamous+cell+carcinoma+cells&rft.au=Day%2C+Chi-Ping%3BEsposito%2C+Dominic%3BMahesh%2C+Cynthia%3BMerlino%2C+Glenn&rft.aulast=Day&rft.aufirst=Chi-Ping&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A comprehensive study to functionally classify the BRCA2 missense mutations found in Fanconi anemia patients T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313052353; 6095900 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Biswas, Kajal AU - Das, Ranabir AU - Alter, Blanche AU - Kuznetsov, Sergey AU - North, Susan AU - Stauffer, Stacey AU - Burkett, Sandra AU - Brody, Lawrence AU - Meyer, Stefan AU - Byrd, Andrew AU - Sharan, Shyam Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Missense mutation KW - anemia KW - Fanconi syndrome KW - BRCA2 protein KW - Anemia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313052353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=A+comprehensive+study+to+functionally+classify+the+BRCA2+missense+mutations+found+in+Fanconi+anemia+patients&rft.au=Biswas%2C+Kajal%3BDas%2C+Ranabir%3BAlter%2C+Blanche%3BKuznetsov%2C+Sergey%3BNorth%2C+Susan%3BStauffer%2C+Stacey%3BBurkett%2C+Sandra%3BBrody%2C+Lawrence%3BMeyer%2C+Stefan%3BByrd%2C+Andrew%3BSharan%2C+Shyam&rft.aulast=Biswas&rft.aufirst=Kajal&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Adoptive T cell therapy: Melanoma and beyond T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313051220; 6095025 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Restifo, Nicholas Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Melanoma KW - Lymphocytes T KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313051220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Adoptive+T+cell+therapy%3A+Melanoma+and+beyond&rft.au=Restifo%2C+Nicholas&rft.aulast=Restifo&rft.aufirst=Nicholas&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Development of recombinant vaccines for the prevention and therapy of human carcinomas T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313050823; 6097431 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Schlom, Jeffrey AU - Gulley, James AU - Madan, Ravi AU - Tsang, Kwong-Yok AU - Greiner, John AU - Palena, Claudia AU - Hodge, James Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - vaccines KW - Prevention KW - Vaccines KW - Carcinoma KW - Tumors KW - Therapy KW - Disease control KW - Recombinants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313050823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Development+of+recombinant+vaccines+for+the+prevention+and+therapy+of+human+carcinomas&rft.au=Schlom%2C+Jeffrey%3BGulley%2C+James%3BMadan%2C+Ravi%3BTsang%2C+Kwong-Yok%3BGreiner%2C+John%3BPalena%2C+Claudia%3BHodge%2C+James&rft.aulast=Schlom&rft.aufirst=Jeffrey&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Part 2: Data Analysis and Dissemination - TCGA data portal and genome data analysis centers T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313045326; 6096184 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Eley, Greg Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Data processing KW - Genomes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313045326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Part+2%3A+Data+Analysis+and+Dissemination+-+TCGA+data+portal+and+genome+data+analysis+centers&rft.au=Eley%2C+Greg&rft.aulast=Eley&rft.aufirst=Greg&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Part 1: Strategy and Goals of TCGA - The effect of technology development on TCGA direction T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313045289; 6096183 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Spellman, Paul Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Technology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313045289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Part+1%3A+Strategy+and+Goals+of+TCGA+-+The+effect+of+technology+development+on+TCGA+direction&rft.au=Spellman%2C+Paul&rft.aulast=Spellman&rft.aufirst=Paul&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Part 1: Strategy and Goals of TCGA - The challenge of tumor accrual and cancer selection T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313045254; 6096182 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Shaw, Kenna Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Cancer KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313045254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Part+1%3A+Strategy+and+Goals+of+TCGA+-+The+challenge+of+tumor+accrual+and+cancer+selection&rft.au=Shaw%2C+Kenna&rft.aulast=Shaw&rft.aufirst=Kenna&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Part 1: Strategy and Goals of TCGA - TCGA 2011-A status report T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313045162; 6096181 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Ozenberger, Bradley Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Cancer KW - Stem cells KW - Oncology KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313045162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Part+1%3A+Strategy+and+Goals+of+TCGA+-+TCGA+2011-A+status+report&rft.au=Ozenberger%2C+Bradley&rft.aulast=Ozenberger&rft.aufirst=Bradley&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Rapid and persistant neutrophil mobilization by novel CXCR4 peptide antagonists T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313043541; 6095336 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Portella, Luigi AU - Napolitano, Maria AU - Riccio, Anna AU - D'Alterio, Crescenzo AU - Polimeno, Marianeve AU - Calemma, Rosa AU - Antignani, Elena AU - Trotta, Annamaria AU - Barbieri, Antonio AU - Gala, Marianna AU - Luciano, Antonio AU - Marcacci, Gianpaolo AU - Amodeo, Pietro AU - Vitale, Rosa AU - De Luca, Stefania AU - Arra, Claudio AU - Castello, Giuseppe AU - Scala, Stefania Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - CXCR4 protein KW - Leukocytes (neutrophilic) KW - Antagonists KW - Peptides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313043541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Rapid+and+persistant+neutrophil+mobilization+by+novel+CXCR4+peptide+antagonists&rft.au=Portella%2C+Luigi%3BNapolitano%2C+Maria%3BRiccio%2C+Anna%3BD%27Alterio%2C+Crescenzo%3BPolimeno%2C+Marianeve%3BCalemma%2C+Rosa%3BAntignani%2C+Elena%3BTrotta%2C+Annamaria%3BBarbieri%2C+Antonio%3BGala%2C+Marianna%3BLuciano%2C+Antonio%3BMarcacci%2C+Gianpaolo%3BAmodeo%2C+Pietro%3BVitale%2C+Rosa%3BDe+Luca%2C+Stefania%3BArra%2C+Claudio%3BCastello%2C+Giuseppe%3BScala%2C+Stefania&rft.aulast=Portella&rft.aufirst=Luigi&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Cancer vaccine immunotherapy employing Saccharomyces cerevisiae (yeast) as a vector can modulate the balance between CD4+ T cells and regulatory T cells (Tregs) and enhance the specific antitumor immune response T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313042941; 6095307 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Vergati, Matteo AU - Cereda, Vittore AU - Intrivici, Chiara AU - Huen, Ngar-Yee AU - Di Bari, Maria AU - Jochems, Caroline AU - Gulley, James AU - Apelian, David AU - Schlom, Jeffrey AU - Tsang, Kwong Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Cancer KW - Immune response KW - Immunotherapy KW - vaccines KW - Lymphocytes T KW - Antitumor activity KW - Immunoregulation KW - CD4 antigen KW - Cancer vaccines KW - Immunity KW - Vaccines KW - Defense mechanisms KW - Disease control KW - Saccharomyces cerevisiae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313042941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Cancer+vaccine+immunotherapy+employing+Saccharomyces+cerevisiae+%28yeast%29+as+a+vector+can+modulate+the+balance+between+CD4%2B+T+cells+and+regulatory+T+cells+%28Tregs%29+and+enhance+the+specific+antitumor+immune+response&rft.au=Vergati%2C+Matteo%3BCereda%2C+Vittore%3BIntrivici%2C+Chiara%3BHuen%2C+Ngar-Yee%3BDi+Bari%2C+Maria%3BJochems%2C+Caroline%3BGulley%2C+James%3BApelian%2C+David%3BSchlom%2C+Jeffrey%3BTsang%2C+Kwong&rft.aulast=Vergati&rft.aufirst=Matteo&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Expression studies from the PVT1 region of 8q24 T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313042573; 6096959 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Huppi, Konrad AU - Pitt, Jason AU - Wahlberg, Brady AU - Jones, Tamara AU - Mushinski, J AU - Janz, Siegfried AU - Caplen, Natasha Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Cancer KW - Stem cells KW - Oncology KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313042573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Expression+studies+from+the+PVT1+region+of+8q24&rft.au=Huppi%2C+Konrad%3BPitt%2C+Jason%3BWahlberg%2C+Brady%3BJones%2C+Tamara%3BMushinski%2C+J%3BJanz%2C+Siegfried%3BCaplen%2C+Natasha&rft.aulast=Huppi&rft.aufirst=Konrad&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Human solid organ cancers contain stem-like label-retaining cancer cells that undergo asymmetric cell division and have superior tumor initiating capacity T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313042400; 6096000 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Xin, Hongwu AU - Hari, Danielle AU - Mullinax, John AU - Ambe, Chenwi AU - Ray, Satyajit AU - Koizumi, Tomotake AU - Wiegand, Gordon AU - Miller, Tyler AU - Andersen, Andrew AU - Garfield, Susan AU - Thorgeirsson, Snorri AU - Avital, Itzhak Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Cancer KW - Organs KW - Tumors KW - Cell division UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313042400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Human+solid+organ+cancers+contain+stem-like+label-retaining+cancer+cells+that+undergo+asymmetric+cell+division+and+have+superior+tumor+initiating+capacity&rft.au=Xin%2C+Hongwu%3BHari%2C+Danielle%3BMullinax%2C+John%3BAmbe%2C+Chenwi%3BRay%2C+Satyajit%3BKoizumi%2C+Tomotake%3BWiegand%2C+Gordon%3BMiller%2C+Tyler%3BAndersen%2C+Andrew%3BGarfield%2C+Susan%3BThorgeirsson%2C+Snorri%3BAvital%2C+Itzhak&rft.aulast=Xin&rft.aufirst=Hongwu&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Tumor suppressor role of microRNA-1 in prostate cancer T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313041506; 6095666 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Hudson, Robert AU - Yi, Ming AU - Esposito, Dominic AU - Stephens, Robert AU - Croce, Carlo AU - Ambs, Stefan Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - prostate cancer KW - Tumors KW - miRNA KW - Tumor suppressor genes KW - Prostate cancer KW - Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313041506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Tumor+suppressor+role+of+microRNA-1+in+prostate+cancer&rft.au=Hudson%2C+Robert%3BYi%2C+Ming%3BEsposito%2C+Dominic%3BStephens%2C+Robert%3BCroce%2C+Carlo%3BAmbs%2C+Stefan&rft.aulast=Hudson&rft.aufirst=Robert&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Dissecting the role of PTEN/Akts in metastatic melanoma T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313041234; 6096846 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Yu, Yanlin AU - Liu, Ziyang AU - Yu, Yixin AU - Mendoza, Arnulfo AU - Khanna, Chand AU - Merlino, Glenn Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Melanoma KW - PTEN protein KW - AKT protein KW - Metastases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313041234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Dissecting+the+role+of+PTEN%2FAkts+in+metastatic+melanoma&rft.au=Yu%2C+Yanlin%3BLiu%2C+Ziyang%3BYu%2C+Yixin%3BMendoza%2C+Arnulfo%3BKhanna%2C+Chand%3BMerlino%2C+Glenn&rft.aulast=Yu&rft.aufirst=Yanlin&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Delineation of grade-specific molecular drivers in inducible preclinical mouse models of astrocytoma T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313041191; 6097225 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Song, Yurong AU - Zhang, Qian AU - Bash, Ryan AU - Yin, Chaoying AU - Yang, Chunyu AU - Gilbert, Debra AU - Wang, Sophie AU - Bullitt, Elizabeth AU - Kafri, Tal AU - McCarthy, Ken AU - Louis, David AU - Miller, C AU - Van Dyke, Terry Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Animal models KW - Molecular modelling KW - Astrocytoma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313041191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Delineation+of+grade-specific+molecular+drivers+in+inducible+preclinical+mouse+models+of+astrocytoma&rft.au=Song%2C+Yurong%3BZhang%2C+Qian%3BBash%2C+Ryan%3BYin%2C+Chaoying%3BYang%2C+Chunyu%3BGilbert%2C+Debra%3BWang%2C+Sophie%3BBullitt%2C+Elizabeth%3BKafri%2C+Tal%3BMcCarthy%2C+Ken%3BLouis%2C+David%3BMiller%2C+C%3BVan+Dyke%2C+Terry&rft.aulast=Song&rft.aufirst=Yurong&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Efficacy of metformin in two mouse models of Li-Fraumeni syndrome T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313039710; 6095515 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Kunnumakkara, Ajaikumar AU - Memmott, Regan AU - Maier, Colleen AU - Kawabata, Shigeru AU - Quinn, Brendan AU - Gills, Joell AU - Dallos, Matthew AU - Hollander, Christine AU - Dennis, Phillip Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Animal models KW - Metformin KW - Li-Fraumeni syndrome KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313039710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Efficacy+of+metformin+in+two+mouse+models+of+Li-Fraumeni+syndrome&rft.au=Kunnumakkara%2C+Ajaikumar%3BMemmott%2C+Regan%3BMaier%2C+Colleen%3BKawabata%2C+Shigeru%3BQuinn%2C+Brendan%3BGills%2C+Joell%3BDallos%2C+Matthew%3BHollander%2C+Christine%3BDennis%2C+Phillip&rft.aulast=Kunnumakkara&rft.aufirst=Ajaikumar&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - CD4+ T cell help differentially influences anti-tumor immunity as a function of T cell avidity T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313039042; 6095557 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Zhu, Ziqiang AU - Singh, Vinod AU - Bronte, Vincenzo AU - Feigenbaum, Lionel AU - Hurwitz, Arthur Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Lymphocytes T KW - Avidity KW - CD4 antigen KW - Immunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313039042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=CD4%2B+T+cell+help+differentially+influences+anti-tumor+immunity+as+a+function+of+T+cell+avidity&rft.au=Zhu%2C+Ziqiang%3BSingh%2C+Vinod%3BBronte%2C+Vincenzo%3BFeigenbaum%2C+Lionel%3BHurwitz%2C+Arthur&rft.aulast=Zhu&rft.aufirst=Ziqiang&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Analysis of studies of germline variation using next generation sequencing and genotyping T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313038549; 6095145 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Jacobs, Kevin Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Genotyping UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313038549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Analysis+of+studies+of+germline+variation+using+next+generation+sequencing+and+genotyping&rft.au=Jacobs%2C+Kevin&rft.aulast=Jacobs&rft.aufirst=Kevin&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Statistical issues in post-GWAS analyses T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313038509; 6095144 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Chatterjee, Nilanjan Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Statistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313038509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Statistical+issues+in+post-GWAS+analyses&rft.au=Chatterjee%2C+Nilanjan&rft.aulast=Chatterjee&rft.aufirst=Nilanjan&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The association between diabetes and cancer incidence and mortality in the NIH-AARP study T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313035311; 6096231 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Lai, Gabriel AU - Park, Yikyung AU - Hartge, Patricia AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Freedman, Neal Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Cancer KW - Mortality KW - Diabetes mellitus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313035311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+association+between+diabetes+and+cancer+incidence+and+mortality+in+the+NIH-AARP+study&rft.au=Lai%2C+Gabriel%3BPark%2C+Yikyung%3BHartge%2C+Patricia%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BFreedman%2C+Neal&rft.aulast=Lai&rft.aufirst=Gabriel&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Guidance on specific funding opportunities and tips for applications T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313030867; 6097157 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Beylin, David Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Financing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313030867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Guidance+on+specific+funding+opportunities+and+tips+for+applications&rft.au=Beylin%2C+David&rft.aulast=Beylin&rft.aufirst=David&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Preventive HPV vaccination: current realities and future possibilities T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313030107; 6097365 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Lowy, Douglas Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Vaccination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313030107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Preventive+HPV+vaccination%3A+current+realities+and+future+possibilities&rft.au=Lowy%2C+Douglas&rft.aulast=Lowy&rft.aufirst=Douglas&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Helicobacter pylori seropositivity and risk of lung cancer T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313027954; 6096707 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Koshiol, Jill AU - Flores, Roberto AU - Lam, Tram AU - Taylor, Philip AU - Weinstein, Stephanie AU - Virtamo, Jarmo AU - Albanes, Demetrius AU - Perez-Perez, Guillermo AU - Caporaso, Neil AU - Blaser, Martin Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Lung cancer KW - Helicobacter pylori UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313027954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Helicobacter+pylori+seropositivity+and+risk+of+lung+cancer&rft.au=Koshiol%2C+Jill%3BFlores%2C+Roberto%3BLam%2C+Tram%3BTaylor%2C+Philip%3BWeinstein%2C+Stephanie%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius%3BPerez-Perez%2C+Guillermo%3BCaporaso%2C+Neil%3BBlaser%2C+Martin&rft.aulast=Koshiol&rft.aufirst=Jill&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Aberrant methylation of multiple tumor suppressor genes and clinicopathological parameters as predictors for genotype-4 hepatitis C virus-associated hepatocellular carcinoma T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313016705; 6095370 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Zekri, Abdel-Rahman AU - Bahnassy, Abeer AU - Shoeab, Fatma AU - Abdel-Aziz, Asherf AU - Ali, Fahmey AU - Sabry, Gilane AU - Dasgupta, Nairajana AU - Daoud, Sayed Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Hepatitis C KW - Tumors KW - Hepatocellular carcinoma KW - DNA methylation KW - Tumor suppressor genes KW - Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313016705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Aberrant+methylation+of+multiple+tumor+suppressor+genes+and+clinicopathological+parameters+as+predictors+for+genotype-4+hepatitis+C+virus-associated+hepatocellular+carcinoma&rft.au=Zekri%2C+Abdel-Rahman%3BBahnassy%2C+Abeer%3BShoeab%2C+Fatma%3BAbdel-Aziz%2C+Asherf%3BAli%2C+Fahmey%3BSabry%2C+Gilane%3BDasgupta%2C+Nairajana%3BDaoud%2C+Sayed&rft.aulast=Zekri&rft.aufirst=Abdel-Rahman&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Role of Interferon Regulatory Factor (IRF)-3 in lung tumor microenvironment T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313015761; 6095354 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Shirota, Hidekazu AU - Klinman, Dennis Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Lung KW - Tumors KW - Microenvironments KW - Interferon regulatory factor UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313015761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Role+of+Interferon+Regulatory+Factor+%28IRF%29-3+in+lung+tumor+microenvironment&rft.au=Shirota%2C+Hidekazu%3BKlinman%2C+Dennis&rft.aulast=Shirota&rft.aufirst=Hidekazu&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Resequence-analysis of 166kb KITLG region in eamilial testicular germ cell tumors T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313014604; 6095211 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Chung, Charles AU - Yeager, Meredith AU - Boland, Joseph AU - Greene, Mark AU - Chanock, Stephen AU - Kratz, Christian Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Tumors KW - Germ cells KW - Testes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313014604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Resequence-analysis+of+166kb+KITLG+region+in+eamilial+testicular+germ+cell+tumors&rft.au=Chung%2C+Charles%3BYeager%2C+Meredith%3BBoland%2C+Joseph%3BGreene%2C+Mark%3BChanock%2C+Stephen%3BKratz%2C+Christian&rft.aulast=Chung&rft.aufirst=Charles&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - How do I choose the correct markers for ancestry estimation and population stratification adjustment? T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313012898; 6095008 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Smith, Michael Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Stratification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313012898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=How+do+I+choose+the+correct+markers+for+ancestry+estimation+and+population+stratification+adjustment%3F&rft.au=Smith%2C+Michael&rft.aulast=Smith&rft.aufirst=Michael&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Alternative dosing regimens with the EGFr inhibitors (Gefitinib and Lapatinib) in a mammary cancer model: Prevention efficacy T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313009916; 6095749 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Lubet, Ronald AU - Bode, Ann AU - Szabo, Eva AU - Grubbs, Clinton Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Cancer KW - Prevention KW - Gefitinib KW - Epidermal growth factor receptors KW - Models KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313009916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Alternative+dosing+regimens+with+the+EGFr+inhibitors+%28Gefitinib+and+Lapatinib%29+in+a+mammary+cancer+model%3A+Prevention+efficacy&rft.au=Lubet%2C+Ronald%3BBode%2C+Ann%3BSzabo%2C+Eva%3BGrubbs%2C+Clinton&rft.aulast=Lubet&rft.aufirst=Ronald&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - caBIGRG overview T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313007150; 6097099 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Heiskanen, Mervi Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313007150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=caBIGRG+overview&rft.au=Heiskanen%2C+Mervi&rft.aulast=Heiskanen&rft.aufirst=Mervi&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Monocyte chemoattractant protein-1 (MCP-1)/CCL2 produced by non-tumor cells in tumor stroma promotes lung metastasis of 4T1 murine breast cancer cells T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313005986; 6095327 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Yoshimura, Teizo AU - Howard, O AU - Matsukawa, Akihiro AU - Chen, Keqiang AU - Liu, Ying AU - Wang, Ji AU - Oppenheim, Joost Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Lung KW - Tumors KW - Breast cancer KW - Monocyte chemoattractant protein 1 KW - Stroma KW - Metastases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313005986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Monocyte+chemoattractant+protein-1+%28MCP-1%29%2FCCL2+produced+by+non-tumor+cells+in+tumor+stroma+promotes+lung+metastasis+of+4T1+murine+breast+cancer+cells&rft.au=Yoshimura%2C+Teizo%3BHoward%2C+O%3BMatsukawa%2C+Akihiro%3BChen%2C+Keqiang%3BLiu%2C+Ying%3BWang%2C+Ji%3BOppenheim%2C+Joost&rft.aulast=Yoshimura&rft.aufirst=Teizo&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Development of predictive biomarkers for anti-TGF-beta therapy T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313004670; 6096538 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Yang, Yu-an AU - Weng, Jia AU - Welsh, Michael AU - Ford, Heide AU - Lonning, Scott AU - Wakefield, Lalage Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Bioindicators KW - biomarkers KW - Prediction KW - Therapy KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313004670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Development+of+predictive+biomarkers+for+anti-TGF-beta+therapy&rft.au=Yang%2C+Yu-an%3BWeng%2C+Jia%3BWelsh%2C+Michael%3BFord%2C+Heide%3BLonning%2C+Scott%3BWakefield%2C+Lalage&rft.aulast=Yang&rft.aufirst=Yu-an&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Anti-tumor efficacy of IMC-A12, a fully human anti-insulin like growth factor 1 receptor (IGF-1R) antibody, against malignant mesothelioma (MM) T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313001014; 6095578 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Kalra, Neetu AU - Zhang, Jingli AU - Yu, Yunkai AU - Ho, Mitchell AU - Cao, Liang AU - Hassan, Raffit Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Growth factors KW - mesothelioma KW - Antibodies KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313001014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Anti-tumor+efficacy+of+IMC-A12%2C+a+fully+human+anti-insulin+like+growth+factor+1+receptor+%28IGF-1R%29+antibody%2C+against+malignant+mesothelioma+%28MM%29&rft.au=Kalra%2C+Neetu%3BZhang%2C+Jingli%3BYu%2C+Yunkai%3BHo%2C+Mitchell%3BCao%2C+Liang%3BHassan%2C+Raffit&rft.aulast=Kalra&rft.aufirst=Neetu&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Preclinical efficacy of AZD8055, an ATP-competitive mammalian target of rapamycin (mTOR) kinase inhibitor, in vitro in clear cell renal cell carcinoma (RCC) T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313000966; 6095577 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Gupta, Gopal AU - Lin, Kelly AU - Sourbier, Carole AU - Baba, Masaya AU - Guichard, Sylvie AU - Linehan, W AU - Srinivasan, Ramaprasad Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - TOR protein KW - Clear cells KW - renal cell carcinoma KW - Tumors KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313000966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Preclinical+efficacy+of+AZD8055%2C+an+ATP-competitive+mammalian+target+of+rapamycin+%28mTOR%29+kinase+inhibitor%2C+in+vitro+in+clear+cell+renal+cell+carcinoma+%28RCC%29&rft.au=Gupta%2C+Gopal%3BLin%2C+Kelly%3BSourbier%2C+Carole%3BBaba%2C+Masaya%3BGuichard%2C+Sylvie%3BLinehan%2C+W%3BSrinivasan%2C+Ramaprasad&rft.aulast=Gupta&rft.aufirst=Gopal&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Genetic determinants of serum retinol: A genome-wide association study T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313000185; 6097488 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Mondul, Alison AU - Yu, Kai AU - Weinstein, Stephanie AU - Virtamo, Jarmo AU - Jacobs, Kevin AU - Kraft, Peter AU - Chanock, Stephen AU - Albanes, Demetrius Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Vitamin A KW - Serum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313000185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Genetic+determinants+of+serum+retinol%3A+A+genome-wide+association+study&rft.au=Mondul%2C+Alison%3BYu%2C+Kai%3BWeinstein%2C+Stephanie%3BVirtamo%2C+Jarmo%3BJacobs%2C+Kevin%3BKraft%2C+Peter%3BChanock%2C+Stephen%3BAlbanes%2C+Demetrius&rft.aulast=Mondul&rft.aufirst=Alison&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Careers in Cancer: Government T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1312999501; 6097314 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - McCaskill-Stevens, Worta Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Cancer KW - Careers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312999501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Careers+in+Cancer%3A+Government&rft.au=McCaskill-Stevens%2C+Worta&rft.aulast=McCaskill-Stevens&rft.aufirst=Worta&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Divergent trends for gastric cancer incidence by anatomic subsite in U.S. adults T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1312998206; 6096823 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Camargo, M AU - Anderson, William AU - King, Jessica AU - Correa, Pelayo AU - Thomas, Cheryll AU - Rosenberg, Philip AU - Eheman, Christie AU - Rabkin, Charles Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - USA KW - Gastric cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312998206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Divergent+trends+for+gastric+cancer+incidence+by+anatomic+subsite+in+U.S.+adults&rft.au=Camargo%2C+M%3BAnderson%2C+William%3BKing%2C+Jessica%3BCorrea%2C+Pelayo%3BThomas%2C+Cheryll%3BRosenberg%2C+Philip%3BEheman%2C+Christie%3BRabkin%2C+Charles&rft.aulast=Camargo&rft.aufirst=M&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Sep15 knockout in mice provides protection against chemically-induced aberrant crypt formation T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1312997992; 6096918 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Tsuji, Petra AU - Carlson, Bradley AU - Yoo, Min-Hyuk AU - Xu, Xue-Ming AU - Naranjo-Suarez, Salvador AU - Fomenko, Dmitri AU - Gladyshev, Vadim AU - Hatfield, Dolph AU - Davis, Cindy Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Mice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312997992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Sep15+knockout+in+mice+provides+protection+against+chemically-induced+aberrant+crypt+formation&rft.au=Tsuji%2C+Petra%3BCarlson%2C+Bradley%3BYoo%2C+Min-Hyuk%3BXu%2C+Xue-Ming%3BNaranjo-Suarez%2C+Salvador%3BFomenko%2C+Dmitri%3BGladyshev%2C+Vadim%3BHatfield%2C+Dolph%3BDavis%2C+Cindy&rft.aulast=Tsuji&rft.aufirst=Petra&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Research Funding/Grant Opportunities: Postdoctoral Level T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1312981130; 6097340 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Marino, Pamela Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Grants KW - Financing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312981130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Research+Funding%2FGrant+Opportunities%3A+Postdoctoral+Level&rft.au=Marino%2C+Pamela&rft.aulast=Marino&rft.aufirst=Pamela&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Impact of feedback, scaffold proteins and Raf heterodimerization on normal and oncogenic B-Raf signaling T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1312947896; 6097593 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Morrison, Deborah Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - scaffolds KW - Feedback KW - Raf protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312947896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Impact+of+feedback%2C+scaffold+proteins+and+Raf+heterodimerization+on+normal+and+oncogenic+B-Raf+signaling&rft.au=Morrison%2C+Deborah&rft.aulast=Morrison&rft.aufirst=Deborah&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Psychosocial correlates of adolescent marijuana use: Variations by status of marijuana use AN - 954633460; 14330519 AB - This study examined the associations between psychosocial factors and status of marijuana use: former experimentation, current occasional, and current frequent use. Methods: Data were collected from a nationally-representative sample of U.S. tenth-graders who participated in the 2005/6 Health Behavior in School-aged Children Study (n = 1465). Multinomial regressions, run separately by gender, examined the association of risk and protective factors from the individual (life satisfaction; academic achievement; aggression, bullying) and contextual (mothers and fathers' knowledge of adolescents' activities, school climate) domains with status of marijuana use (former experimentation, current occasional use, current frequent use). Results: Former experimental and current marijuana uses were negatively associated with protective factors such as academic achievement, mothers' and fathers' knowledge of adolescents' activities, and life satisfaction, but not with positive school climate. Former experimental and current marijuana uses were positively associated with aggression and bullying perpetration. Most associations varied by gender and status of marijuana use. In adjusted analyses, aggression emerged as the sole risk factor and fathers' knowledge as the sole protective factor associated with most statuses of marijuana use, across gender. Conclusion: Fathers may be particularly important in preventing adolescent marijuana use, and interventions promoting fathers' knowledge of adolescents' activities are warranted. JF - Addictive Behaviors AU - Farhat, Tilda AU - Simons-Morton, Bruce AU - Luk, Jeremy W AD - Prevention Research Branch, Division of Epidemiology, Statistics and Prevention Research,, farhatti@mail.nih.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 404 EP - 407 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 36 IS - 4 SN - 0306-4603, 0306-4603 KW - Risk Abstracts KW - USA KW - Adolescents KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954633460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+Behaviors&rft.atitle=Psychosocial+correlates+of+adolescent+marijuana+use%3A+Variations+by+status+of+marijuana+use&rft.au=Farhat%2C+Tilda%3BSimons-Morton%2C+Bruce%3BLuk%2C+Jeremy+W&rft.aulast=Farhat&rft.aufirst=Tilda&rft.date=2011-04-01&rft.volume=36&rft.issue=4&rft.spage=404&rft.isbn=&rft.btitle=&rft.title=Addictive+Behaviors&rft.issn=03064603&rft_id=info:doi/10.1016%2Fj.addbeh.2010.11.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Adolescents; USA DO - http://dx.doi.org/10.1016/j.addbeh.2010.11.017 ER - TY - JOUR T1 - Bacterial Small RNA Regulators: Versatile Roles and Rapidly Evolving Variations AN - 926880223; 16109072 AB - Small RNA regulators (sRNAs) have been identified in a wide range of bacteria and found to play critical regulatory roles in many processes. The major families of sRNAs include true antisense RNAs, synthesized from the strand complementary to the mRNA they regulate, sRNAs that also act by pairing but have limited complementarity with their targets, and sRNAs that regulate proteins by binding to and affecting protein activity. The sRNAs with limited complementarity are akin to eukaryotic microRNAs in their ability to modulate the activity and stability of multiple mRNAs. In many bacterial species, the RNA chaperone Hfq is required to promote pairing between these sRNAs and their target mRNAs. Understanding the evolution of regulatory sRNAs remains a challenge; sRNA genes show evidence of duplication and horizontal transfer but also could be evolved from tRNAs, mRNAs or random transcription. JF - Cold Spring Harbor Perspectives in Biology AU - Gottesman, Susan AU - Storz, Gisela AD - Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892 PY - 2011 SP - a003798 PB - Cold Spring Harbor Laboratory Press, Fulfillment & Distribution Dept. Woodbury NY 11797-2924 United States VL - 3 IS - 12 SN - 1943-0264, 1943-0264 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Bacteria KW - mRNA stability KW - tRNA KW - Antisense RNA KW - miRNA KW - Transcription KW - Chaperones KW - Evolutionary genetics KW - Complementarity KW - Evolution KW - Horizontal transfer KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926880223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cold+Spring+Harbor+Perspectives+in+Biology&rft.atitle=Bacterial+Small+RNA+Regulators%3A+Versatile+Roles+and+Rapidly+Evolving+Variations&rft.au=Gottesman%2C+Susan%3BStorz%2C+Gisela&rft.aulast=Gottesman&rft.aufirst=Susan&rft.date=2011-04-01&rft.volume=3&rft.issue=12&rft.spage=a003798&rft.isbn=&rft.btitle=&rft.title=Cold+Spring+Harbor+Perspectives+in+Biology&rft.issn=19430264&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - mRNA stability; tRNA; miRNA; Antisense RNA; Transcription; Chaperones; Evolutionary genetics; Horizontal transfer; Evolution; Complementarity; Bacteria ER - TY - JOUR T1 - INNOVATIVE TECHNOLOGIES: MRI-Based Atlas of the Developing Mouse Brain Debuts AN - 918044831; 14874537 JF - Environmental Health Perspectives AU - Holzman, David C AD - David C. Holzman writes on science, medicine, energy, economics, and cars from Lexington and Wellfleet, MA. His work has appeared in Smithsonian, The Atlantic Monthly, and the Journal of the National Cancer Institute Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - A165 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 119 IS - 4 SN - 0091-6765, 0091-6765 KW - Environment Abstracts KW - Brain KW - innovations KW - Technology KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918044831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=INNOVATIVE+TECHNOLOGIES%3A+MRI-Based+Atlas+of+the+Developing+Mouse+Brain+Debuts&rft.au=Holzman%2C+David+C&rft.aulast=Holzman&rft.aufirst=David&rft.date=2011-04-01&rft.volume=119&rft.issue=4&rft.spage=A165&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Brain; innovations; Technology ER - TY - JOUR T1 - Novel HIV-1 Protease Inhibitors (PIs) Containing a Bicyclic P2 Functional Moiety, Tetrahydropyrano-Tetrahydrofuran, That Are Potent against Multi-PI-Resistant HIV-1 Variants AN - 911167619; 16062525 AB - We identified GRL-1388 and -1398, potent nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran (Tp-THF). GRL-1388 was as potent as darunavir (DRV) against various drug-resistant HIV-1 laboratory strains with 50% effective concentration (EC50s) of 2.6 to 32.6 nM. GRL-1398 was significantly more potent against such variants than DRV with EC50s of 0.1 to 5.7 nM. GRL-1388 and -1398 were also potent against multiple-PI-resistant clinical HIV-1 variants (CLHIV-1MDR) with EC50s ranging from 2.7 to 21.3 nM and from 0.3 to 4.8 nM, respectively. A highly DRV-resistant HIV-1 variant selected in vitro remained susceptible to GRL-1398 with the EC50 of 21.9 nM, while the EC50 of DRV was 214.1 nM. When HIV-1NL4-3 was selected with GRL-1398, four amino acid substitutions-leucine to phenylalanine at a position 10 (L10F), A28S, L33F, and M46I-emerged, ultimately enabling the virus to replicate in the presence of >1.0 mu M the compound beyond 57 weeks of selection. When a mixture of 10 different CLHIV-1MDR strains was selected, the emergence of resistant variants was more substantially delayed with GRL-1398 than with GRL-1388 and DRV. Modeling analyses revealed that GRL-1398 had greater overall hydrogen bonding and hydrophobic interactions than GRL-1388 and DRV and that GRL-1388 and -1398 had hydrogen bonding interactions with the main chain of the active-site amino acids (Asp29 and Asp30) of protease. The present findings warrant that GRL-1398 be further developed as a potential drug for treating individuals with HIV-1 infection. JF - Antimicrobial Agents & Chemotherapy AU - Ide, Kazuhiko AU - Aoki, Manabu AU - Amano, Masayuki AU - Koh, Yasuhiro AU - Yedidi, Ravikiran S AU - Das, Debananda AU - Leschenko, Sofiya AU - Chapsal, Bruno AU - Ghosh, Arun K AU - Mitsuya, Hiroaki AD - Departments of Hematology, Rheumatology, and Infectious Diseases, Kumamoto University Graduate School of Medicine, Kumamoto 860-8556, Japan, hmitsuya@helix.nih.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 1717 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 55 IS - 4 SN - 0066-4804, 0066-4804 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Amino acids KW - Drug resistance KW - Drugs KW - Hydrogen bonding KW - Hydrophobicity KW - Infection KW - Phenylalanine KW - Proteinase inhibitors KW - Human immunodeficiency virus 1 KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911167619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Novel+HIV-1+Protease+Inhibitors+%28PIs%29+Containing+a+Bicyclic+P2+Functional+Moiety%2C+Tetrahydropyrano-Tetrahydrofuran%2C+That+Are+Potent+against+Multi-PI-Resistant+HIV-1+Variants&rft.au=Ide%2C+Kazuhiko%3BAoki%2C+Manabu%3BAmano%2C+Masayuki%3BKoh%2C+Yasuhiro%3BYedidi%2C+Ravikiran+S%3BDas%2C+Debananda%3BLeschenko%2C+Sofiya%3BChapsal%2C+Bruno%3BGhosh%2C+Arun+K%3BMitsuya%2C+Hiroaki&rft.aulast=Ide&rft.aufirst=Kazuhiko&rft.date=2011-04-01&rft.volume=55&rft.issue=4&rft.spage=1717&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.01540-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Number of references - 37 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Amino acids; Hydrogen bonding; Drug resistance; Proteinase inhibitors; Hydrophobicity; Infection; Drugs; Phenylalanine; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1128/AAC.01540-10 ER - TY - JOUR T1 - Immune Response to Dengue Virus and Prospects for a Vaccine AN - 907186342; 16061089 AB - Dengue viruses (DENV) are mosquito-borne members of the Flavivirus genus and include four serotypes (DENV-1, DENV-2, DENV-3, and DENV-4) each of which is capable of causing dengue fever and dengue hemorrhagic fever/dengue shock syndrome. Serious disease can be seen during primary infection, but is more frequent following second infection with a serotype different from that of a previous infection. Infection with wild-type DENV induces high titered neutralizing antibody that can provide long-term immunity to the homotypic virus and can provide short-term immunity (only several months duration) to a heterotypic DENV. The high level of virus replication seen during both secondary infection with a heterotypic virus and during primary DENV infection in late infancy is a direct consequence of antibody-dependent enhancement of replication. This enhanced virus replication is mediated primarily by pre-existing, non- or subneutralizing antibodies to the virion surface antigens that enhance access of the virion-antibody complex to Fc gamma R-bearing cells. Vaccines will need to provide long-term protection against each of the four DENV serotypes by inducing neutralizing antibodies, and live-attenuated and various non-living virus vaccines are in development. JF - Annual Review of Immunology AU - Murphy, B AU - Whitehead, S S AD - Laboratory of Infectious Diseases, NIH, NIAID, Bethesda, MD 20892-8007, USA Y1 - 2011/04// PY - 2011 DA - April 2011 VL - 29 SN - 0732-0582, 0732-0582 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Virology & AIDS Abstracts; Immunology Abstracts KW - Dengue virus KW - Virions KW - Human diseases KW - Serotypes KW - Viruses KW - Disease control KW - Flavivirus KW - Public health KW - Antigens KW - Dengue KW - Replication KW - Secondary infection KW - Immunity KW - Dengue hemorrhagic fever KW - Antibodies KW - Shock KW - surface antigens KW - Reviews KW - Immune response KW - Vaccines KW - V 22350:Immunology KW - F 06905:Vaccines KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907186342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Immunology&rft.atitle=Immune+Response+to+Dengue+Virus+and+Prospects+for+a+Vaccine&rft.au=Murphy%2C+B%3BWhitehead%2C+S+S&rft.aulast=Murphy&rft.aufirst=B&rft.date=2011-04-01&rft.volume=29&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Immunology&rft.issn=07320582&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Antibodies; Human diseases; Antigens; Replication; Viruses; Disease control; Immunity; Vaccines; Public health; Virions; Serotypes; Secondary infection; Dengue hemorrhagic fever; Shock; Dengue; surface antigens; Reviews; Immune response; Dengue virus; Flavivirus ER - TY - JOUR T1 - IL-27 and IL-21 Are Associated with T Cell IL-10 Responses in Human Visceral Leishmaniasis AN - 907159708; 14540847 AB - IL-10 is believed to underlie many of the immunologic defects in human visceral leishmaniasis (VL). We have identified CD4+CD25-Foxp3- T cells as the major source of IL-10 in the VL spleen. IL-27, a member of the IL-6/IL-12 cytokine family, has been shown to promote development of IL-10-producing T cells, in part by upregulating their production of autocrine IL-21. We investigated whether IL-27 and IL-21 are associated with human VL. IL-27 was elevated in VL plasma, and at pretreatment, spleen cells showed significantly elevated mRNA levels of both IL-27 subunits, IL-27p28 and EBI-3, as well as IL-21, compared with posttreatment biopsies. CD14+ spleen cells were the main source of IL-27 mRNA, whereas CD3+ T cells were the main source of IL-21. IL-27 mRNA could be strongly upregulated in normal donor macrophages with IFN- gamma and IL-1 beta , conditions consistent with those in the VL spleen. Last, a whole-blood assay revealed that most VL patients could produce Ag-specific IFN- gamma and IL-10 and that the IL-10 could be augmented with recombinant human IL-21. Thus, proinflammatory cytokines acting on macrophages in the VL spleen have the potential to upregulate IL-27, which in turn can induce IL-21 to expand IL-10-producing T cells as a mechanism of feedback control. JF - Journal of Immunology AU - Ansari, Nasim Akhtar AU - Kumar, Rajiv AU - Gautam, Shalini AU - Nylen, Susanne AU - Singh, Om Prakash AU - Sundar, Shyam AU - Sacks, David AD - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2011/04/01/ PY - 2011 DA - 2011 Apr 01 SP - 3977 EP - 3985 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA VL - 186 IS - 7 SN - 0022-1767, 0022-1767 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Interleukin 6 KW - Macrophages KW - gamma -Interferon KW - Visceral leishmaniasis KW - Immunology KW - Interleukin 1 KW - Spleen KW - Biopsy KW - Interleukin 21 KW - Interleukin 10 KW - mRNA KW - Inflammation KW - Defects KW - Recombinants KW - Interleukin 12 KW - Autocrine signalling KW - Interleukin 27 KW - Lymphocytes T KW - Feedback KW - CD3 antigen KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907159708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=IL-27+and+IL-21+Are+Associated+with+T+Cell+IL-10+Responses+in+Human+Visceral+Leishmaniasis&rft.au=Ansari%2C+Nasim+Akhtar%3BKumar%2C+Rajiv%3BGautam%2C+Shalini%3BNylen%2C+Susanne%3BSingh%2C+Om+Prakash%3BSundar%2C+Shyam%3BSacks%2C+David&rft.aulast=Ansari&rft.aufirst=Nasim&rft.date=2011-04-01&rft.volume=186&rft.issue=7&rft.spage=3977&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Recombinants; Macrophages; Immunology; Spleen; Defects; Interleukin 6; gamma -Interferon; Visceral leishmaniasis; Interleukin 1; Biopsy; Interleukin 21; Interleukin 10; Inflammation; mRNA; Interleukin 12; Autocrine signalling; Interleukin 27; Lymphocytes T; Feedback; CD3 antigen ER - TY - JOUR T1 - Functional analysis of conserved sequences within a temporally restricted neural precursor cell enhancer AN - 904468359; 14617070 AB - Many of the key regulators of Drosophila CNS neural identity are expressed in defined temporal orders during neuroblast (NB) lineage development. To begin to understand the structural and functional complexity of enhancers that regulate ordered NB gene expression programs, we have undertaken the mutational analysis of the temporally restricted nerfin-1 NB enhancer. Our previous studies have localized the enhancer to a region just proximal to the nerfin-1 transcription start site. Analysis of this enhancer, using the phylogenetic footprint program EvoPrinter, reveals the presence of multiple sequence blocks that are conserved among drosophilids. cis-Decoder alignments of these conserved sequence blocks (CSBs) has identified shorter elements that are conserved in other Drosophila NB enhancers. Mutagenesis of the enhancer reveals that although each CSB is required for wild-type expression, neither position nor orientation of the CSBs within the enhancer is crucial for enhancer function; removal of less-conserved or non-conserved sequences flanking CSB clusters also does not significantly alter enhancer activity. While all three conserved E-box transcription factor (TF) binding sites (CAGCTG) are required for full function, adding an additional site at different locations within non-conserved sequences interferes with enhancer activity. Of particular note, none of the mutations resulted in ectopic reporter expression outside of the early NB expression window, suggesting that the temporally restricted pattern is defined by transcriptional activators and not by direct DNA binding repressors. Our work also points to an unexpectedly large number of TFs required for optimal enhancer function - mutant TF analysis has identified at least four that are required for full enhancer regulation. JF - Mechanisms of Development AU - Kuzin, Alexander AU - Kundu, Mukta AU - Brody, Thomas AU - Odenwald, Ward F AD - Neural Cell-Fate Determinants Section, NINDS, NIH Bethesda, MD, USA Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 165 EP - 177 PB - Elsevier Science VL - 128 IS - 3-4 SN - 0925-4773, 0925-4773 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids KW - Central nervous system KW - Conserved sequence KW - DNA KW - Enhancers KW - Gene expression KW - Mutagenesis KW - Mutation KW - Neural stem cells KW - Neuroblasts KW - Phylogeny KW - Repressors KW - Structure-function relationships KW - Temporal variations KW - Transcription factors KW - Drosophila KW - N 14835:Protein-Nucleic Acids Association KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904468359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mechanisms+of+Development&rft.atitle=Functional+analysis+of+conserved+sequences+within+a+temporally+restricted+neural+precursor+cell+enhancer&rft.au=Kuzin%2C+Alexander%3BKundu%2C+Mukta%3BBrody%2C+Thomas%3BOdenwald%2C+Ward+F&rft.aulast=Kuzin&rft.aufirst=Alexander&rft.date=2011-04-01&rft.volume=128&rft.issue=3-4&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Mechanisms+of+Development&rft.issn=09254773&rft_id=info:doi/10.1016%2Fj.mod.2011.02.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-10-08 N1 - SubjectsTermNotLitGenreText - Phylogeny; Central nervous system; Temporal variations; Mutagenesis; Gene expression; Enhancers; Structure-function relationships; Transcription factors; DNA; Conserved sequence; Neuroblasts; Repressors; Neural stem cells; Mutation; Drosophila DO - http://dx.doi.org/10.1016/j.mod.2011.02.001 ER - TY - JOUR T1 - Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies AN - 902377524; 15815419 AB - Introduction: Sepsis remains a leading cause of death worldwide. Despite years of extensive research, effective drugs that inhibit the pro-inflammatory effects of lipopolysaccharide (LPS) and improve outcome when added to conventional sepsis treatments are lacking. Eritoran tetrasodium (E5564) is a promising candidate therapy for sepsis belonging to a new class of such drugs which inhibit LPS-induced inflammation by blocking toll-like receptor 4. Areas covered: This review focuses on the rationale for the use of eritoran tetrasodium in sepsis as well as on its pharmacokinetics, pharmacodynamics, efficacy and safety. Preclinical and clinical studies from a MEDLINE/PubMed literature search in August 2010 with the search terms ``eritoran'' and ``E5564'' are discussed. Expert opinion: Preclinical in vitro and in vivo studies of eritoran tetrasodium indicate it can limit excessive inflammatory mediator release associated with LPS and improve survival in sepsis models. While early clinical results are promising, its efficacy and safety for treating patients with sepsis are currently under investigation. Even if the ongoing Phase III clinical trial enrolling patients with severe sepsis and increased risk of death shows benefit from eritoran, questions remain and confirmatory studies would be necessary to define its clinical usage. JF - Expert Opinion on Drug Metabolism and Toxicology AU - Barochia, Amisha AU - Solomon, Steven AU - Cui, Xizhong AU - Natanson, Charles AU - Eichacker, Peter Q AD - National Institutes of Health, Clinical Center, Critical Care Medicine Department, Building 10, Room 2C145, Bethesda, MD 20892, USA ++1 301 496 9320; ++1 301 402 1213, barochiaav@mail.nih.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 479 EP - 494 PB - Informa Healthcare VL - 7 IS - 4 SN - 1742-5255, 1742-5255 KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - Survival KW - Drug development KW - Clinical trials KW - Pharmacokinetics KW - Models KW - Inflammation KW - Sepsis KW - Reviews KW - Lipopolysaccharides KW - TLR4 protein KW - Drugs KW - Pharmacodynamics KW - Toll-like receptors KW - X 24370:Natural Toxins KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902377524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+Opinion+on+Drug+Metabolism+and+Toxicology&rft.atitle=Eritoran+tetrasodium+%28E5564%29+treatment+for+sepsis%3A+review+of+preclinical+and+clinical+studies&rft.au=Barochia%2C+Amisha%3BSolomon%2C+Steven%3BCui%2C+Xizhong%3BNatanson%2C+Charles%3BEichacker%2C+Peter+Q&rft.aulast=Barochia&rft.aufirst=Amisha&rft.date=2011-04-01&rft.volume=7&rft.issue=4&rft.spage=479&rft.isbn=&rft.btitle=&rft.title=Expert+Opinion+on+Drug+Metabolism+and+Toxicology&rft.issn=17425255&rft_id=info:doi/10.1517%2F17425255.2011.558190 L2 - http://www.ingentaconnect.com/content/apl/emt/2011/00000007/00000004/art00008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Survival; Drug development; Clinical trials; Pharmacokinetics; Inflammation; Models; Sepsis; Reviews; Lipopolysaccharides; Drugs; TLR4 protein; Toll-like receptors; Pharmacodynamics DO - http://dx.doi.org/10.1517/17425255.2011.558190 ER - TY - JOUR T1 - Burgeoning Directions for the Prevention of Youth Violence AN - 902082840; 201104729 AB - Despite focused efforts toward the prevention of youth violence within the United States, it continues to adversely affect the lives of children and families within our communities and society at large. The articles in this issue address risk and protective factors that affect violence among urban youth to inform prevention and treatment. Pathways to youth violence are complex and may begin early. Prevention efforts in school, family, and community settings that address risk and protective factors within a socially, culturally, and ecologically valid context early in human development are crucial. While challenges remain for the prevention of youth violence, research suggests opportunities to improve our efforts. Federal agency initiatives in partnership with communities are currently underway to increase the knowledge base and advance prevention of youth violence among diverse populations. Adapted from the source document. JF - Journal of Prevention & Intervention in the Community AU - Boyce, Cheryl Anne AU - Robinson, W LaVome AU - Richards, Maryse H AD - National Institutes of Health, Bethesda, Maryland, USA Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 93 EP - 97 PB - Taylor & Francis, Philadelphia PA VL - 39 IS - 2 SN - 1085-2352, 1085-2352 KW - African American pathways prevention youth violence KW - Prevention KW - Public Health KW - Urban Areas KW - Risk Factors KW - Intervention KW - Violence KW - Knowledge KW - Youth KW - article KW - 6143: child & family welfare KW - 6124: health care promotion/education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902082840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Prevention+%26+Intervention+in+the+Community&rft.atitle=Burgeoning+Directions+for+the+Prevention+of+Youth+Violence&rft.au=Boyce%2C+Cheryl+Anne%3BRobinson%2C+W+LaVome%3BRichards%2C+Maryse+H&rft.aulast=Boyce&rft.aufirst=Cheryl&rft.date=2011-04-01&rft.volume=39&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+Prevention+%26+Intervention+in+the+Community&rft.issn=10852352&rft_id=info:doi/10.1080%2F10852352.2011.556554 LA - English DB - Social Services Abstracts N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Prevention; Youth; Violence; Risk Factors; Intervention; Knowledge; Public Health; Urban Areas DO - http://dx.doi.org/10.1080/10852352.2011.556554 ER - TY - JOUR T1 - A Retrospective Cohort Study of Structured Abstracts in MEDLINE, 1992-2006 AN - 902065051; 201108696 AB - Structured abstracts contain distinct labeled sections (e.g.'RESULTS'). MEDLINE is an online database containing English-language abstracts of articles appearing in the journals that are indexed by the U.S. National Library of Medicine (NLM). To assess the usefulness of MEDLINE structured abstracts in enhancing bibliographic retrieval, they were reviewed by NLM between 1989 and 1991. Among the findings: the structured abstract formats prescribed by different journals varied considerably; structured abstracts were becoming increasing popular; MEDLINE records with structured abstracts typically tended to have more access points than MEDLINE records as a whole. This article discusses the results of a retrospective cohort study aimed at measuring and characterizing the growth in structured abstracts in MEDLINE since 1991, with a view again toward exploring their utility in enhancing information display and retrieval. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Ripple, Anna M AU - Mork, James G AU - Knecht, Lou S AU - Humphreys, Betsy L AD - National Library of Medicine, National Institutes of Health, US Department of Health and Human Services, 8600 Rockville Pike, Bethesda, MD 20894 ripple@nlm.nih.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 160 EP - 163 PB - Medical Library Association, Chicago, IL VL - 99 IS - 2 SN - 1536-5050, 1536-5050 KW - MEDLINE KW - Abstracts KW - Online information retrieval KW - article KW - 13.23: ONLINE DATABASES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902065051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=A+Retrospective+Cohort+Study+of+Structured+Abstracts+in+MEDLINE%2C+1992-2006&rft.au=Ripple%2C+Anna+M%3BMork%2C+James+G%3BKnecht%2C+Lou+S%3BHumphreys%2C+Betsy+L&rft.aulast=Ripple&rft.aufirst=Anna&rft.date=2011-04-01&rft.volume=99&rft.issue=2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/ L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Abstracts; Online information retrieval; MEDLINE ER - TY - JOUR T1 - Trends in meat consumption in the USA AN - 899149288; 15748188 AB - To characterize the trends, distribution, potential determinants and public health implications of meat consumption within the USA. We examined temporal trends in meat consumption using food availability data from the FAO and US Department of Agriculture (USDA), and further evaluated the meat intake by type (red, white, processed) in the National Health and Nutrition Examination Surveys (NHANES) linked to the MyPyramid Equivalents Database (MPED). Overall meat consumption has continued to rise in the USA and the rest of the developed world. Despite a shift towards higher poultry consumption, red meat still represents the largest proportion of meat consumed in the USA (58 %). Twenty-two per cent of the meat consumed in the USA is processed. According to the NHANES 2003-2004, total meat intake averaged 128 g/d. The type and quantities of meat reported varied by education, race, age and gender. Given the plausible epidemiological evidence for red and processed meat intake in cancer and chronic disease risk, understanding the trends and determinants of meat consumption in the USA, where meat is consumed at more than three times the global average, should be particularly pertinent to researchers and other public health professionals aiming to reduce the global burden of chronic disease. JF - Public Health Nutrition AU - Daniel, Carrie R AU - Cross, Amanda J AU - Koebnick, Corinna AU - Sinha, Rashmi AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., Bethesda, MD 20892, USA, Carrie.Daniel@nih.hhs.gov Carrie.Daniel@nih.hhs.gov Carrie.Daniel@nih.hhs.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 575 EP - 583 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 14 IS - 4 SN - 1368-9800, 1368-9800 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Cancer KW - USA KW - meat KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899149288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Nutrition&rft.atitle=Trends+in+meat+consumption+in+the+USA&rft.au=Daniel%2C+Carrie+R%3BCross%2C+Amanda+J%3BKoebnick%2C+Corinna%3BSinha%2C+Rashmi&rft.aulast=Daniel&rft.aufirst=Carrie&rft.date=2011-04-01&rft.volume=14&rft.issue=4&rft.spage=575&rft.isbn=&rft.btitle=&rft.title=Public+Health+Nutrition&rft.issn=13689800&rft_id=info:doi/10.1017%2FS1368980010002077 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - meat; USA DO - http://dx.doi.org/10.1017/S1368980010002077 ER - TY - JOUR T1 - Fatherhood and incident prostate cancer in a prospective US cohort AN - 899145430; 15583644 AB - Background Fatherhood status has been hypothesized to affect prostate cancer risk but the current evidence is limited and contradictory.Methods We prospectively evaluated the relationship between offspring number and the risk of prostate cancer in 161 823 men enrolled in the National Institues of Health - American Association of Retired Persons Diet and Health Study. Participants were aged 50-71 years without a cancer diagnosis at baseline in 1995. Analysing 8134 cases of prostate cancer, Cox regression was used to estimate the association between offspring number and prostate cancer incidence while accounting for socio-demographic and lifestyle characteristics.Results When examining the entire cohort, there was no relationship between fatherhood and incident prostate cancer [hazard ratio (HR) 0.94, 95% confidence interval (CI) 0.86-1.02]. However, after stratifying for prostate cancer screening, prostate-specific antigen (PSA) unscreened childless men had a lower risk of prostate cancer (HR 0.73, 95% CI 0.58-0.91) compared with fathers due to the interaction between PSA screening and fatherhood (P for interaction < 0.01). A trend for the lower risk of prostate cancer among unscreened fathers compared with childless men was seen for low-grade prostate cancer (HR 0.78, 95% CI 0.61-1.01), high-grade prostate cancer (HR 0.62, 95% CI 0.37-1.04) and even fatal prostate cancer (HR 0.28, 95% CI 0.07-1.12). The number of children fathered was not related to prostate cancer (P sub(trend) = 0.1 7). In addition, men's inability to sire female offspring showed a weak positive association with prostate cancer in the PSA unscreened study subjects.Conclusions Our findings suggest fatherhood status and offspring gender is associated with a man's prostate cancer risk. JF - International Journal of Epidemiology AU - Eisenberg, Michael L AU - Park, Yikyung AU - Brinton, Louise A AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AD - super(1)Department of Urology, University of California San Francisco, San Francisco, CA, USA, super(2)Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA and super(3)AARP, Washington, DC, USA, michael.eisenberg@gmail.com Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 480 EP - 487 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 40 IS - 2 SN - 0300-5771, 0300-5771 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Cancer KW - Children KW - Diets KW - Gender KW - Offspring KW - offspring KW - prostate cancer KW - USA KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899145430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Epidemiology&rft.atitle=Fatherhood+and+incident+prostate+cancer+in+a+prospective+US+cohort&rft.au=Eisenberg%2C+Michael+L%3BPark%2C+Yikyung%3BBrinton%2C+Louise+A%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur&rft.aulast=Eisenberg&rft.aufirst=Michael&rft.date=2011-04-01&rft.volume=40&rft.issue=2&rft.spage=480&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Epidemiology&rft.issn=03005771&rft_id=info:doi/10.1093%2Fije%2Fdyq163 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Diets; Gender; Offspring; Children; prostate cancer; Cancer; offspring; USA DO - http://dx.doi.org/10.1093/ije/dyq163 ER - TY - JOUR T1 - DDN: a caBIG super( registered ) analytical tool for differential network analysis AN - 899143724; 15609862 AB - Summary: Differential dependency network (DDN) is a caBIG super( registered ) (cancer Biomedical Informatics Grid) analytical tool for detecting and visualizing statistically significant topological changes in transcriptional networks representing two biological conditions. Developed under caBIG super( registered ) 's In Silico Research Centers of Excellence (ISRCE) Program, DDN enables differential network analysis and provides an alternative way for defining network biomarkers predictive of phenotypes. DDN also serves as a useful systems biology tool for users across biomedical research communities to infer how genetic, epigenetic or environment variables may affect biological networks and clinical phenotypes. Besides the standalone Java application, we have also developed a Cytoscape plug-in, CytoDDN, to integrate network analysis and visualization seamlessly. JF - Bioinformatics AU - Zhang, Bai AU - Tian, Ye AU - Jin, Lu AU - Li, Huai AU - Shih, Ie-Ming AU - Madhavan, Subha AU - Clarke, Robert AU - Hoffman, Eric P AU - Xuan, Jianhua AU - Hilakivi-Clarke, Leena AU - Wang, Yue AD - super(1)Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, super(2)Bioinformatics Unit, RRB, National Institute on Aging, NIH, Baltimore, MD 21224, super(3)Departments of Gynecology/Obstetrics, Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, super(4)Lombardi Comprehensive Cancer Center and Department of Oncology, Georgetown University, Washington, DC 20057 and super(5)Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA Y1 - 2011/04/01/ PY - 2011 DA - 2011 Apr 01 SP - 1036 EP - 1038 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 27 IS - 7 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Data processing KW - epigenetics KW - Statistical analysis KW - Transcription KW - Bioinformatics KW - biomarkers KW - Internet KW - Cancer KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899143724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=DDN%3A+a+caBIG+super%28+registered+%29+analytical+tool+for+differential+network+analysis&rft.au=Zhang%2C+Bai%3BTian%2C+Ye%3BJin%2C+Lu%3BLi%2C+Huai%3BShih%2C+Ie-Ming%3BMadhavan%2C+Subha%3BClarke%2C+Robert%3BHoffman%2C+Eric+P%3BXuan%2C+Jianhua%3BHilakivi-Clarke%2C+Leena%3BWang%2C+Yue&rft.aulast=Zhang&rft.aufirst=Bai&rft.date=2011-04-01&rft.volume=27&rft.issue=7&rft.spage=1036&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtr052 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Computer programs; Data processing; epigenetics; Statistical analysis; Transcription; Bioinformatics; biomarkers; Cancer; Internet DO - http://dx.doi.org/10.1093/bioinformatics/btr052 ER - TY - JOUR T1 - Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae AN - 899141388; 15568603 AB - EndA is a sequence non-specific endonuclease that serves as a virulence factor during Streptococcus pneumoniae infection. Expression of EndA provides a strategy for evasion of the host's neutrophil extracellular traps, digesting the DNA scaffold structure and allowing further invasion by S. pneumoniae. To define mechanisms of catalysis and substrate binding, we solved the structure of EndA at 1.75 Aa resolution. The EndA structure reveals a DRGH (Asp-Arg-Gly-His) motif-containing beta beta alpha -metal finger catalytic core augmented by an interesting 'finger-loop' interruption of the active site alpha -helix. Subsequently, we delineated DNA binding versus catalytic functionality using structure-based alanine substitution mutagenesis. Three mutants, H154A, Q186A and Q192A, exhibited decreased nuclease activity that appears to be independent of substrate binding. Glu205 was found to be crucial for catalysis, while residues Arg127/Lys128 and Arg209/Lys210 contribute to substrate binding. The results presented here provide the molecular foundation for development of specific antibiotic inhibitors for EndA. JF - Nucleic Acids Research AU - Moon, Andrea F AU - Midon, Marika AU - Meiss, Gregor AU - Pingoud, Alfred AU - London, Robert E AU - Pedersen, Lars C AD - super(1)Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709, USA and super(2)Institute of Biochemistry, Justus-Liebig-University Giessen, Heinrich-Buff-Ring 58, D-35392 Giessen, Germany, pederse2@niehs.nih.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 2943 EP - 2953 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 39 IS - 7 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Alanine KW - virulence factors KW - Leukocytes (neutrophilic) KW - Nuclease KW - Antibiotics KW - Infection KW - scaffolds KW - Mutagenesis KW - Finger KW - Streptococcus pneumoniae KW - DNA structure KW - DNA KW - Endonuclease KW - Catalysis KW - J 02310:Genetics & Taxonomy KW - N 14835:Protein-Nucleic Acids Association KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899141388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Structural+insights+into+catalytic+and+substrate+binding+mechanisms+of+the+strategic+EndA+nuclease+from+Streptococcus+pneumoniae&rft.au=Moon%2C+Andrea+F%3BMidon%2C+Marika%3BMeiss%2C+Gregor%3BPingoud%2C+Alfred%3BLondon%2C+Robert+E%3BPedersen%2C+Lars+C&rft.aulast=Moon&rft.aufirst=Andrea&rft.date=2011-04-01&rft.volume=39&rft.issue=7&rft.spage=2943&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkq1152 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - virulence factors; Alanine; Leukocytes (neutrophilic); Nuclease; Antibiotics; Infection; scaffolds; Finger; Mutagenesis; DNA structure; DNA; Endonuclease; Catalysis; Streptococcus pneumoniae DO - http://dx.doi.org/10.1093/nar/gkq1152 ER - TY - JOUR T1 - Pesticide application and health hazards: implications for farmers and the environment AN - 888102352; 15410095 AB - This study investigated unsafe work practices, health hazards, and the association between pesticide residues with environmental problems in six communities in the largest vegetable producing province in the Philippines. Tools used were a structured questionnaire encompassing the work exposure assessment of 542 farmers engaged in vegetable production. The majority of the farmers were pyrethroid users, followed by users of organophosphate and then carbamate. The risk factors noted in the study were use of incomplete personal protective equipment, wiping sweat with a piece of residue-contaminated fabric, re-entering recently sprayed area, dermal contact with spills from leakage of backpack sprayers, and other spills while mixing pesticides. Organophosphate use was significantly associated with the symptom of skin itchiness (r = 0.74). The study showed that farmers used unsafe work practices and were exposed to health hazards related to pesticide use. Pesticide use should be governed by standards for occupational exposure and environmental health. JF - International Journal of Environmental Studies AU - Lu, Jinky Leilanie AU - Cosca, Katherine AD - National Institutes of Health, University of the Philippines Manila, Manila, Philippines 1100 Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 197 EP - 208 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 68 IS - 2 SN - 0020-7233, 0020-7233 KW - Risk Abstracts; Pollution Abstracts; Health & Safety Science Abstracts; Environment Abstracts KW - Farmers KW - Environmental hazards KW - Organophosphate KW - Carbamate KW - Pyrethroid KW - Organochlorine KW - Pesticide residue KW - Philippines KW - Skin KW - Leakage KW - Organophosphates KW - Pesticide residues KW - Risk factors KW - Sprays KW - Environmental health KW - Protective equipment KW - Occupational exposure KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888102352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Environmental+Studies&rft.atitle=Pesticide+application+and+health+hazards%3A+implications+for+farmers+and+the+environment&rft.au=Lu%2C+Jinky+Leilanie%3BCosca%2C+Katherine&rft.aulast=Lu&rft.aufirst=Jinky&rft.date=2011-04-01&rft.volume=68&rft.issue=2&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Environmental+Studies&rft.issn=00207233&rft_id=info:doi/10.1080%2F00207233.2010.542657 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Leakage; Skin; Pesticide residues; Organophosphates; Risk factors; Sprays; Environmental health; Protective equipment; Occupational exposure; Philippines DO - http://dx.doi.org/10.1080/00207233.2010.542657 ER - TY - JOUR T1 - Repeated exposure to moderate doses of ethanol augments hippocampal glutamate neurotransmission by increasing release AN - 888099919; 15051501 AB - The present study used conventional and quantitative microdialysis to assess glutamatergic and GABAergic neurotransmission in the hippocampal CA3 area of the rat following a moderate-dose ethanol treatment regimen. Male Wistar rats received 3.4g/kg of ethanol or water for 6 days via gastric gavage. Microdialysis experiments commenced 2 days later. Basal and depolarization-induced glutamate overflow were significantly elevated in ethanol-treated animals. Basal and depolarization-induced gamma-aminobutyric acid (GABA) overflow were unaltered. Quantitative no-net-flux microdialysis was used to determine if changes in dialysate glutamate levels following ethanol administration are due to an increase in release or a decrease in uptake. To confirm the validity of this method for quantifying basal glutamate dynamics, extracellular concentrations of glutamate and the extraction fraction, which reflects changes in analyte clearance, were quantified in response to retro-dialysis of the glutamate uptake blocker trans-pyrrolidine-2,4-dicarboxylic acid (tPDC). tPDC significantly decreased the extraction fraction for glutamate, resulting in augmented extracellular glutamate concentrations. Repeated ethanol administration did not alter the glutamate extraction fraction. However, extracellular glutamate concentrations were significantly elevated, indicating that glutamate release is increased as a consequence of repeated ethanol administration. These data demonstrate that repeated bouts of moderate ethanol consumption alter basal glutamate dynamics in the CA3 region of the dorsal hippocampus. Basal glutamate release is augmented, whereas glutamate uptake is unchanged. Furthermore, they suggest that dysregulation of glutamate transmission in this region may contribute to the previously documented deficits in cognitive function associated with moderate dose ethanol use. JF - Addiction Biology AU - Chefer, Vladimir AU - Meis, Jennifer AU - Wang, Grace AU - Kuzmin, Alexander AU - Bakalkin, Georgy AU - Shippenberg, Toni AD - Integrative Neuroscience Section, Integrative Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, USA Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 229 EP - 237 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 16 IS - 2 SN - 1355-6215, 1355-6215 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Microdialysis KW - Glutamatergic transmission KW - Data processing KW - Neurotransmission KW - Hippocampus KW - Cognitive ability KW - gamma -Aminobutyric acid KW - Glutamic acid KW - Addiction KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888099919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+Biology&rft.atitle=Repeated+exposure+to+moderate+doses+of+ethanol+augments+hippocampal+glutamate+neurotransmission+by+increasing+release&rft.au=Chefer%2C+Vladimir%3BMeis%2C+Jennifer%3BWang%2C+Grace%3BKuzmin%2C+Alexander%3BBakalkin%2C+Georgy%3BShippenberg%2C+Toni&rft.aulast=Chefer&rft.aufirst=Vladimir&rft.date=2011-04-01&rft.volume=16&rft.issue=2&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Addiction+Biology&rft.issn=13556215&rft_id=info:doi/10.1111%2Fj.1369-1600.2010.00272.x L2 - http://www.ingentaconnect.com/content/bpl/adb/2011/00000016/00000002/art00005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2014-10-02 N1 - SubjectsTermNotLitGenreText - Microdialysis; Glutamatergic transmission; Data processing; Neurotransmission; Cognitive ability; Hippocampus; gamma -Aminobutyric acid; Addiction; Glutamic acid; Ethanol DO - http://dx.doi.org/10.1111/j.1369-1600.2010.00272.x ER - TY - JOUR T1 - Racial and Gender Disparities in Implantable Cardioverter-Defibrillator Placement: Are They Due to Overuse or Underuse AN - 881448464; 201113937 AB - Previous studies documented racial and gender disparities in implantable cardioverter-defibrillator (ICD) placement. The authors examined whether racial and gender disparities in ICD placement are due to underutilization or overutilization. Among 1,054 adults hospitalized from 2001 to 2004 with ventricular arrhythmias in a large academic hospital, the study found that 17% of patients had clinical indicators concordant with ICD placement criteria. Among those, Blacks were less likely than Whites to receive an ICD (adjusted odds ratio [OR] = 0.24; 95% CI = 0.08-0.71). Among the 83% who were discordant with ICD placement criteria, Blacks (adjusted OR = 0.30; 95% CI = 0.18-0.52) and Hispanics (adjusted OR = 0.24, 95% CI = 0.10-0.57) were less likely than Whites, and women less likely than men, to receive an ICD (adjusted OR = 0.48; 95% CI = 0.34-0.67). In this cohort, these differences appear related to overutilization among men and Whites who are discordant with ICD placement criteria in addition to underutilization among Blacks concordant with placement criteria. [Copyright Sage Publications, Inc.] JF - Medical Care Research and Review AU - Cook, Nakela L AU - Orav, E John AU - Liang, Catherine L AU - Guadagnoli, Edward AU - Hicks, LeRoi S AD - National Heart, Lung, and Blood Institute, Bethesda, MD, USA cookn2@nhlbi.nih.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 226 EP - 246 PB - Sage Publications, Thousand Oaks CA VL - 68 IS - 2 SN - 1077-5587, 1077-5587 KW - Disparities Race/Ethnicity Sex Implantable-Cardioverter Defibrillator Ventricular Arrhythmia KW - Racial differences KW - Gender KW - Racial inequalities KW - Gender inequalities KW - Underuse KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881448464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Care+Research+and+Review&rft.atitle=Racial+and+Gender+Disparities+in+Implantable+Cardioverter-Defibrillator+Placement%3A+Are+They+Due+to+Overuse+or+Underuse&rft.au=Cook%2C+Nakela+L%3BOrav%2C+E+John%3BLiang%2C+Catherine+L%3BGuadagnoli%2C+Edward%3BHicks%2C+LeRoi+S&rft.aulast=Cook&rft.aufirst=Nakela&rft.date=2011-04-01&rft.volume=68&rft.issue=2&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Medical+Care+Research+and+Review&rft.issn=10775587&rft_id=info:doi/10.1177%2F1077558710379421 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-08-04 N1 - Number of references - 36 N1 - Last updated - 2016-09-27 N1 - CODEN - MCRRFH N1 - SubjectsTermNotLitGenreText - Racial inequalities; Underuse; Gender; Racial differences; Gender inequalities; Hospitals DO - http://dx.doi.org/10.1177/1077558710379421 ER - TY - JOUR T1 - Effects of Hormonally Active Agents on Steroid Hormone Receptor Expression and Cell Proliferation in the Myometrium of Ovariectomized Macaques AN - 876245379; 14875089 AB - Hormone replacement therapy and selective estrogen receptor modulators have been controversial treatment options for postmenopausal women because of their potential health benefits and/or risks. In this study, we determine the effects of the hormonally active compounds, conjugated equine estrogens (CEE), medroxyprogesterone acetate (MPA), CEE + MPA, and tamoxifen (TAM) on the myometrium of ovariectomized macaques. Immunoexpression of estrogen receptor- alpha (ER alpha ), progesterone receptor (PR), and Ki-67 in the myometrium is assessed. We found no significant difference in ER alpha myometrial expression in the CEE, MPA, and CEE + MPA treatment groups, but there was a significant decrease in expression in animals administered TAM versus controls. Conjugated equine estrogen-, TAM-, and CEE + MPA-treated animals had significantly increased expression of PR in myometrial cells and there was no difference in PR expression in cells from MPA-treated animals versus control animals. Myometrial cell proliferation did not significantly differ between the controls and any of the treatment groups, although normalized Ki-67 values were somewhat higher in the CEE and TAM groups. These data suggest that ER alpha and PR expression in the myometrium is influenced by treatment with hormonally active agents. JF - Toxicologic Pathology AU - Hill, Georgette D AU - Moore, Alicia B AU - Kissling, Grace E AU - Flagler, Norris D AU - Ney, Elizabeth AU - Cline, JMark AU - Dixon, Darlene AD - Integrated Laboratory Systems (ILS), Research Triangle Park, North Carolina, USA, dixon@niehs.nih.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 508 EP - 515 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 39 IS - 3 SN - 0192-6233, 0192-6233 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Cell proliferation KW - Macaca KW - myometrium KW - X 24310:Pharmaceuticals KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876245379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Effects+of+Hormonally+Active+Agents+on+Steroid+Hormone+Receptor+Expression+and+Cell+Proliferation+in+the+Myometrium+of+Ovariectomized+Macaques&rft.au=Hill%2C+Georgette+D%3BMoore%2C+Alicia+B%3BKissling%2C+Grace+E%3BFlagler%2C+Norris+D%3BNey%2C+Elizabeth%3BCline%2C+JMark%3BDixon%2C+Darlene&rft.aulast=Hill&rft.aufirst=Georgette&rft.date=2011-04-01&rft.volume=39&rft.issue=3&rft.spage=508&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623311401045 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Number of references - 1 N1 - Last updated - 2014-04-03 N1 - SubjectsTermNotLitGenreText - myometrium; Macaca DO - http://dx.doi.org/10.1177/0192623311401045 ER - TY - JOUR T1 - Histopathological Evaluation of the Nervous System in National Toxicology Program Rodent Studies: A Modified Approach AN - 876245377; 14875088 AB - This article outlines the changes and underlying rationale for modifications to the histopathological evaluation of the nervous system during toxicology and carcinogenesis studies conducted by the National Toxicology Program (NTP). In the past, routine evaluation of the nervous system was mostly limited to three sections of brain, and occasionally the spinal cord and peripheral nerves. Factors such as the increasing occurrence of human neurological diseases and associated economical cost burden, the role of unidentified environmental stressors in neurodegenerative disorders, multiple therapeutic drug-induced neuropathies noted in human clinical trials, and the exponential use of environmental chemicals with unknown neurotoxic potential necessitate a more extensive evaluation of the nervous system. The NTP has modified its protocol to include examination of key anatomic subsites related to neurodegenerative diseases such as Parkinson's disease. Modifications include four additional sections of the brain. Increasing the number of brain sections permits examination of a greater number of specific anatomic subsites with unique vulnerability. In addition, the spinal cord, peripheral nerves, trigeminal ganglion, and intestinal autonomic ganglia will be evaluated as needed. It is expected that this modified approach will increase the sensitivity of detecting neurotoxicants and neurocarcinogens important in human neurologic and neurodegenerative disorders. JF - Toxicologic Pathology AU - Rao, Deepa B AU - Little, Peter B AU - Malarkey, David E AU - Herbert, Ronald A AU - Sills, Robert C AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA Integrated Laboratory Systems, Inc., Research Triangle Park, North Carolina, USA, sills@niehs.nih.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 463 EP - 470 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 39 IS - 3 SN - 0192-6233, 0192-6233 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Autonomic ganglia KW - Brain KW - Carcinogenesis KW - Clinical trials KW - Intestine KW - Movement disorders KW - Nervous system KW - Neurodegenerative diseases KW - Neurological diseases KW - Neuropathy KW - Neurotoxicity KW - Parkinson's disease KW - Peripheral nerves KW - Spinal cord KW - Trigeminal ganglion KW - X 24310:Pharmaceuticals KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876245377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Histopathological+Evaluation+of+the+Nervous+System+in+National+Toxicology+Program+Rodent+Studies%3A+A+Modified+Approach&rft.au=Rao%2C+Deepa+B%3BLittle%2C+Peter+B%3BMalarkey%2C+David+E%3BHerbert%2C+Ronald+A%3BSills%2C+Robert+C&rft.aulast=Rao&rft.aufirst=Deepa&rft.date=2011-04-01&rft.volume=39&rft.issue=3&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623311401044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Number of references - 79 N1 - Last updated - 2012-08-24 N1 - SubjectsTermNotLitGenreText - Neurological diseases; Spinal cord; Parkinson's disease; Brain; Trigeminal ganglion; Clinical trials; Neurodegenerative diseases; Nervous system; Movement disorders; Carcinogenesis; Neurotoxicity; Intestine; Autonomic ganglia; Peripheral nerves; Neuropathy DO - http://dx.doi.org/10.1177/0192623311401044 ER - TY - JOUR T1 - Circulating levels of genistein in the neonate, apart from dose and route, predict future adverse female reproductive outcomes AN - 876232462; 14880327 AB - Developmental exposure to estrogenic compounds can disrupt sexual differentiation and adult reproductive function in many animals including humans. Phytoestrogens (plant estrogens) in the diet comprise a significant source of estrogenic exposure to humans, particularly in infants who are fed soy-based infant formula. Animal models have been developed to test the effects of phytoestrogen exposure on the developing fetus and neonate. Here we review studies quantifying the amount of phytoestrogen exposure in human adults and infants and discuss the few available epidemiological studies that have addressed long-term consequences of developmental phytoestrogen exposure. We then describe in detail rodent models of developmental exposure to the most prevalent phytoestrogen in soy products, genistein, and the effects of this exposure on female reproductive function. These models have used various dosing strategies to mimic the phytoestrogen levels in human populations. Serum circulating levels of genistein following each of the models and their correlation to reproductive outcomes are also discussed. Taken together, the studies clearly demonstrate that environmentally relevant doses of genistein have significant negative impacts on ovarian differentiation, estrous cyclicity, and fertility in the rodent model. Additional studies of reproductive function in human populations exposed to high levels of phytoestrogens during development are warranted. JF - Reproductive Toxicology AU - Jefferson, Wendy N AU - Williams, Carmen J AD - Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States, jeffers1@niehs.nih.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 272 EP - 279 PB - Elsevier Science, Box 882 New York NY 10159 USA VL - 31 IS - 3 SN - 0890-6238, 0890-6238 KW - Environment Abstracts; Toxicology Abstracts KW - infant formulas KW - Fertility KW - Infant formulas KW - Animal models KW - Differentiation KW - Phytoestrogens KW - Estrus cycle KW - Diets KW - Estrogens KW - Sex differentiation KW - Fetuses KW - Soybeans KW - Reviews KW - human populations KW - Neonates KW - rodents KW - Genistein KW - estrogens KW - Infants KW - X 24320:Food Additives & Contaminants KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876232462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=Circulating+levels+of+genistein+in+the+neonate%2C+apart+from+dose+and+route%2C+predict+future+adverse+female+reproductive+outcomes&rft.au=Jefferson%2C+Wendy+N%3BWilliams%2C+Carmen+J&rft.aulast=Jefferson&rft.aufirst=Wendy&rft.date=2011-04-01&rft.volume=31&rft.issue=3&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/10.1016%2Fj.reprotox.2010.10.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diets; Infant formulas; Estrogens; Fertility; Animal models; Sex differentiation; Fetuses; Soybeans; Differentiation; Reviews; Phytoestrogens; Neonates; Genistein; Estrus cycle; Infants; infant formulas; human populations; rodents; estrogens DO - http://dx.doi.org/10.1016/j.reprotox.2010.10.001 ER - TY - JOUR T1 - Impact of a New Gender-Specific Definition for Binge Drinking on Prevalence Estimates for Women AN - 875713035; 201112874 AB - Binge drinking accounts for more than half of the 79,000 deaths due to excessive drinking in the U.S. each year. In 2006, the Behavioral Risk Factor Surveillance System (BRFSS) lowered the threshold for defining binge drinking among women from >=5 drinks to >=4 drinks per occasion, in accordance with national recommendations To assess changes in binge-drinking prevalence among women. Methods: The relative and absolute change in binge drinking among U.S. adult women was assessed using pooled BRFSS data from the 2 years before (2004-2005) and after (2006-2007) the implementation of the new gender-specific definition. Analyses were conducted in 2008-2009. Results: Binge-drinking prevalence among women increased 2.6 percentage points (from 7.3% in 2004-2005 to 9.9% in 2006-2007), a 35.6% relative increase. The percentage of women who reported consuming exactly 4 drinks in 2006 (3.6%) was similar to the increase in the prevalence of binge drinking among women that was observed from 2005 to 2006 (absolute change=2.9 percentage points). Conclusions: The new gender-specific definition of binge drinking significantly increased the identification of women drinking at dangerous levels. The change in prevalence among women was primarily due to the change in the definition and not to actual changes in drinking behavior. The new gender-specific definition of binge drinking can increase the usefulness of this measure for public health surveillance and support the planning and implementation of effective prevention strategies (e.g., increasing alcohol excise taxes). [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Chavez, Pollyanna R AU - Nelson, David E AU - Naimi, Timothy S AU - Brewer, Robert D AD - Alcohol Program, Emerging Investigations and Analytic Methods Branch, Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, Georgia Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 468 EP - 471 PB - Elsevier Science, New York NY VL - 40 IS - 4 SN - 0749-3797, 0749-3797 KW - Alcohol consumption KW - Binge drinking KW - Women KW - Gender differences KW - Public health KW - Prevalence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875713035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Impact+of+a+New+Gender-Specific+Definition+for+Binge+Drinking+on+Prevalence+Estimates+for+Women&rft.au=Chavez%2C+Pollyanna+R%3BNelson%2C+David+E%3BNaimi%2C+Timothy+S%3BBrewer%2C+Robert+D&rft.aulast=Chavez&rft.aufirst=Pollyanna&rft.date=2011-04-01&rft.volume=40&rft.issue=4&rft.spage=468&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2010.12.008 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-07-07 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Binge drinking; Women; Alcohol consumption; Prevalence; Gender differences; Public health DO - http://dx.doi.org/10.1016/j.amepre.2010.12.008 ER - TY - JOUR T1 - IKK beta phosphorylation regulates RPS3 nuclear translocation and NF- Kappa B function during infection with Escherichia coli strain O157:H7 AN - 874181661; 14865567 AB - NF- Kappa B is a major gene regulator in immune responses, and ribosomal protein S3 (RPS3) is an NF- Kappa B subunit that directs specific gene transcription. However, it is unknown how nuclear translocation of RPS3 is regulated. Here we report that phosphorylation of RPS3 Ser209 by the kinase IKK beta was crucial for nuclear localization of RPS3 in response to activating stimuli. Moreover, virulence protein NleH1 of the foodborne pathogen Escherichia coli strain O157:H7 specifically inhibited phosphorylation of RPS3 Ser209 and blocked RPS3 function, thereby promoting bacterial colonization and diarrhea but resulting in less mortality in a gnotobiotic piglet-infection model. Thus, the IKK beta -dependent modification of a specific amino acid in RPS3 promoted specific NF- Kappa B functions that underlie the molecular pathogenetic mechanisms of E. coli O157:H7. JF - Nature Immunology AU - Wan, Fengyi AU - Weaver, Amanda AU - Gao, Xiaofei AU - Bern, Michael AU - Hardwidge, Philip R AU - Lenardo, Michael J AD - 1] Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. [2] Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA. Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 335 EP - 343 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 12 IS - 4 SN - 1529-2908, 1529-2908 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Mortality KW - Amino acids KW - Diarrhea KW - Food KW - Animal models KW - Transcription KW - Pathogens KW - Infection KW - NF- Kappa B protein KW - Virulence KW - Colonization KW - Nuclear transport KW - Phosphorylation KW - Escherichia coli KW - Gnotobiotics KW - Immune response KW - ribosomal protein S3 KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874181661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Immunology&rft.atitle=IKK+beta+phosphorylation+regulates+RPS3+nuclear+translocation+and+NF-+Kappa+B+function+during+infection+with+Escherichia+coli+strain+O157%3AH7&rft.au=Wan%2C+Fengyi%3BWeaver%2C+Amanda%3BGao%2C+Xiaofei%3BBern%2C+Michael%3BHardwidge%2C+Philip+R%3BLenardo%2C+Michael+J&rft.aulast=Wan&rft.aufirst=Fengyi&rft.date=2011-04-01&rft.volume=12&rft.issue=4&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Nature+Immunology&rft.issn=15292908&rft_id=info:doi/10.1038%2Fni.2007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Mortality; Diarrhea; Amino acids; Food; Animal models; Transcription; Pathogens; Infection; NF- Kappa B protein; Virulence; Nuclear transport; Colonization; Phosphorylation; Gnotobiotics; Immune response; ribosomal protein S3; Escherichia coli DO - http://dx.doi.org/10.1038/ni.2007 ER - TY - JOUR T1 - The frequency and specificity of human neutrophil antigen antibodies in a blood donor population AN - 872132133; 14717650 AB - BACKGROUND: Transfusion-related acute lung injury (TRALI) has been associated with both human leukocyte antigen (HLA) and human neutrophil antigen (HNA) antibodies. HNA antibody frequency, specificity, and demographic associations have not been well defined in the blood donor population. STUDY DESIGN AND METHODS: A subset of 1171 donors (388 nontransfused males, 390 HLA antibody-negative females with three or more pregnancies, and 393 HLA antibody-positive females with three or more pregnancies) from a larger Leukocyte Antibody Prevalence Study was tested for immunoglobulin (Ig)G and IgM HNA antibody using a granulocyte immunofluorescence flow cytometry assay. Additional testing on selected samples included monoclonal antibody immobilization of granulocyte antigen-flow cytometry and granulocyte genotyping. RESULTS: Eight samples were HNA antibody positive (prevalence, 0.7%; 95% confidence interval [CI], 0.3%-1.3%]). Three HNA antibodies (one IgG and two IgM) were found in nontransfused males (prevalence, 0.8%; 95% CI, 0.2%-2.2%); all were panreactive or nonspecific. One HLA antibody-negative previously pregnant female had an IgG HNA antibody with HNA-1a specificity (prevalence, 0.3%; 95% CI, 0.01%-1.4%). Four HLA antibody-positive previously pregnant females demonstrated HNA antibodies, three IgG and one IgM (prevalence, 1%; 95% CI, 0.3%-2.6%). Two of these were HNA-1a specific, one HNA-4a specific, and one nonspecific. CONCLUSIONS: HNA antibodies occur with low frequency in the donor population and are present in both male and female donors. Despite the implementation of TRALI reduction strategies, HNA antibodies are still present in donor blood products. Although our data do not create a case for urgent implementation of donor HNA antibody testing, future new developments for high-throughput HNA antibody screening, including for HNA-3a, may warrant reconsideration. JF - Transfusion AU - Gottschall, Jerome L AU - Triulzi, Darrell J AU - Curtis, Brian AU - Kakaiya, Ram M AU - Busch, Michael P AU - Norris, Philip J AU - Glynn, Simone A AU - Carrick, Danielle AU - Wright, David J AU - Kleinman, Steve AD - From the BloodCenter ofWisconsin, Milwaukee, Wisconsin; the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania; the Blood Systems Research Institute and Blood Centers of the Pacific, San Francisco, California; the National Heart, Lung and Blood Institute, Bethesda, Maryland; and Westat Corporation, Rockville, Maryland. Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 820 EP - 827 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 51 IS - 4 SN - 0041-1132, 0041-1132 KW - Health & Safety Science Abstracts KW - blood donors KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872132133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=The+frequency+and+specificity+of+human+neutrophil+antigen+antibodies+in+a+blood+donor+population&rft.au=Gottschall%2C+Jerome+L%3BTriulzi%2C+Darrell+J%3BCurtis%2C+Brian%3BKakaiya%2C+Ram+M%3BBusch%2C+Michael+P%3BNorris%2C+Philip+J%3BGlynn%2C+Simone+A%3BCarrick%2C+Danielle%3BWright%2C+David+J%3BKleinman%2C+Steve&rft.aulast=Gottschall&rft.aufirst=Jerome&rft.date=2011-04-01&rft.volume=51&rft.issue=4&rft.spage=820&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2010.02913.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Document feature - figure 0 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - blood donors DO - http://dx.doi.org/10.1111/j.1537-2995.2010.02913.x ER - TY - JOUR T1 - Birth characteristics and female sex hormone concentrations during adolescence: results from the Dietary Intervention Study in Children AN - 872130691; 14541873 AB - Background: Birth characteristics and adult hormone concentrations influence breast cancer risk, but little is known about the influence of birth characteristics on hormone concentrations, particularly during adolescence. Methods: We evaluated the association of birth characteristics (birth weight, birth length, and gestational age) with serum sex hormone concentrations during late childhood and adolescence in 278 female participants of the Dietary Intervention Study in Children. Repeated measures analysis of variance models were used to assess the relationships of birth characteristics and serum estrogens and androgens at five different time points over a mean period of 7years. Results: In analyses that did not take into account time from blood draw until menarche, birth weight was inversely associated with pre-menarche concentrations of estradiol, estrone sulfate, androstenedione, testosterone, and dehydroepiandrosterone sulfate (DHEAS). In the post-menarche analyses, birth weight was not significantly associated with concentration of any of the hormones under investigation. Birth length and gestational age were not associated with hormone concentrations before or after menarche. Conclusion: Birth weight is inversely associated with sex hormone concentrations before menarche in the model unadjusted for time from blood draw until menarche. Impact: The in utero environment has long-term influences on the hormonal milieu, which could potentially contribute to breast cancer risk. JF - Cancer Causes & Control AU - Ruder, Elizabeth H AU - Hartman, Terryl J AU - Rovine, Michael J AU - Dorgan, Joanne F AD - Cancer Prevention Fellowship Program, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Suite 320, MSC 7236, Bethesda, MD, 20892, USA, rudereh@mail.nih.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 611 EP - 621 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 22 IS - 4 SN - 0957-5243, 0957-5243 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Adolescents KW - Age KW - Birth weight KW - Breast cancer KW - Cancer KW - Children KW - Diets KW - Hormones KW - Intervention KW - birth weight KW - intervention KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872130691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Birth+characteristics+and+female+sex+hormone+concentrations+during+adolescence%3A+results+from+the+Dietary+Intervention+Study+in+Children&rft.au=Ruder%2C+Elizabeth+H%3BHartman%2C+Terryl+J%3BRovine%2C+Michael+J%3BDorgan%2C+Joanne+F&rft.aulast=Ruder&rft.aufirst=Elizabeth&rft.date=2011-04-01&rft.volume=22&rft.issue=4&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9734-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Diets; Birth weight; Age; intervention; Intervention; Breast cancer; birth weight; Children; Hormones; Cancer; Adolescents DO - http://dx.doi.org/10.1007/s10552-011-9734-7 ER - TY - JOUR T1 - Participation of Chromosome Segregation Protein ParAI of Vibrio cholerae in Chromosome Replication AN - 872129725; 14584050 AB - Vibrio cholerae carries homologs of plasmid-borne parA and parB genes on both of its chromosomes. The par genes help to segregate many plasmids and chromosomes. Here we have studied the par genes of V. cholerae chromosome I. Earlier studies suggested that ParBI binds to the centromeric site parSI near the origin of replication (oriI), and parSI-ParBI complexes are placed at the cell poles by ParAI. Deletion of parAI and parSI caused the origin-proximal DNA to be less polar. Here we found that deletion of parBI also resulted in a less polar localization of oriI. However, unlike the deletion of parAI, the deletion of parBI increased the oriI number. Replication was normal when both parAI and parBI were deleted, suggesting that ParBI mediates its action through ParAI. Overexpression of ParAI in a parABI-deleted strain also increased the DNA content. The results are similar to those found for Bacillus subtilis, where ParA (Soj) stimulates replication and this activity is repressed by ParB (SpoOJ). As in B. subtilis, the stimulation of replication most likely involves the replication initiator DnaA. Our results indicate that control of chromosomal DNA replication is an additional function of chromosomal par genes conserved across the Gram-positive/Gram-negative divide. JF - Journal of Bacteriology AU - Kadoya, Ryosuke AU - Baek, Jong Hwan AU - Sarker, Arnab AU - Chattoraj, Dhruba K AD - Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland 20892, chattoraj@nih.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 1504 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 193 IS - 7 SN - 0021-9193, 0021-9193 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Oceanic Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - DNA biosynthesis KW - Bacillus subtilis KW - chromosome I KW - Replication KW - Plasmids KW - Vibrio cholerae KW - Chromosomes KW - Replication origins KW - DNA KW - Proteins KW - Bacteriology KW - J 02310:Genetics & Taxonomy KW - O 1010:Viruses, Bacteria, Protists, Fungi and Plants KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872129725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Participation+of+Chromosome+Segregation+Protein+ParAI+of+Vibrio+cholerae+in+Chromosome+Replication&rft.au=Kadoya%2C+Ryosuke%3BBaek%2C+Jong+Hwan%3BSarker%2C+Arnab%3BChattoraj%2C+Dhruba+K&rft.aulast=Kadoya&rft.aufirst=Ryosuke&rft.date=2011-04-01&rft.volume=193&rft.issue=7&rft.spage=1504&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01067-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Number of references - 77 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Chromosomes; Replication; DNA; Proteins; Plasmids; Bacteriology; DNA biosynthesis; chromosome I; Replication origins; Vibrio cholerae; Bacillus subtilis DO - http://dx.doi.org/10.1128/JB.01067-10 ER - TY - JOUR T1 - Cyber and Traditional Bullying: Differential Association With Depression AN - 870996126; 201112685 AB - The study compared levels of depression among bullies, victims, and bully-victims of traditional (physical, verbal, and relational) and cyber bullying that is a relatively new form of bullying. The study also examined the association between depression and frequency of involvement in each form of bullying. Methods: A U.S. nationally representative sample of students in grades 6-10 (N = 7,313) completed the bullying and depression items in the Health Behavior in School-Aged Children 2005 Survey. Results: Depression was associated with each of the four forms of bullying. Cyber victims reported higher depression than bullies or bully-victims, a result not observed in other forms of bullying. For physical, verbal, and relational bullies, the frequently-involved group of victims and bully victims reported a significantly higher level of depression than the corresponding occasionally involved group. For cyber bullying, differences were found only between the occasional and frequent victims. Conclusion: Results indicated the importance of further study of cyber bullying because its association with depression was distinct from traditional forms of bullying. [Copyright The Society for Adolescent Medicine; published by Elsevier Inc.] JF - Journal of Adolescent Health AU - Wang, Jing AU - Nansel, Tonja R AU - Iannotti, Ronald J AD - Division of Epidemiology, Statistics, and Prevention Research, Prevention Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland wangji2@mail.nih.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 415 EP - 417 PB - Elsevier, New York NY VL - 48 IS - 4 SN - 1054-139X, 1054-139X KW - Cyber bullying Traditional bullying Depression KW - Depression KW - Victims KW - Children KW - Bullying KW - Health behaviour KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/870996126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=Cyber+and+Traditional+Bullying%3A+Differential+Association+With+Depression&rft.au=Wang%2C+Jing%3BNansel%2C+Tonja+R%3BIannotti%2C+Ronald+J&rft.aulast=Wang&rft.aufirst=Jing&rft.date=2011-04-01&rft.volume=48&rft.issue=4&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/10.1016%2Fj.jadohealth.2010.07.012 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-06-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JAHCD9 N1 - SubjectsTermNotLitGenreText - Bullying; Depression; Victims; Health behaviour; Children DO - http://dx.doi.org/10.1016/j.jadohealth.2010.07.012 ER - TY - JOUR T1 - Feasibility of an Audio Computer-Assisted Self-Interview Method to Self-Assess Sexual Maturation AN - 870996035; 201112366 AB - Sexual maturation assessment using physical examination may no longer be feasible in some large epidemiologic surveys, such as National Health and Nutrition Examination Survey, because of the sensitivity of the examination and privacy concerns. This study tested the feasibility of a new automated audio computer-assisted self-interview (ACASI) module for children and adolescents for self-assessment of sexual maturation. Methods: A cross-sectional feasibility study was conducted at a large urban children/adolescent clinic in Washington D.C. Self-assessed sexual maturation (Tanner stages) was reported by 234 youths (119 boys and 115 girls) aged 8-18 years by using the ACASI module. Girls assessed their breast and pubic hair development, and boys assessed their genital and pubic hair development. Self-assessments were compared with Tanner stages recorded by clinical examiners during routine well-child physical examinations conducted on the same day. Results: There was good/excellent agreement between boy's self-assessment and the examiner's assessment of their genital stage (weighted [kappa]: .65, 95% confidence interval [CI]: .55-.75) and pubic hair stage (weighted [kappa]: .78, CI: .70-.86). There was excellent agreement between girl's self-assessment and the examiner's assessment of their breast stage (weighted [kappa]: .81, CI: .74-.87) and pubic hair stage (weighted [kappa]: .78, CI: .71-.86). Conclusion: The ACASI method is a feasible method of pubertal self-assessment for participants as young as 8 years in large epidemiologic surveys. However, additional testing is needed to determine the validity of this ACASI module. [Copyright The Society for Adolescent Medicine; published by Elsevier Inc.] JF - Journal of Adolescent Health AU - Lamb, Molly M AU - Beers, Lee AU - Reed-Gillette, Debra AU - McDowell, Margaret A AD - Division of the Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 325 EP - 330 PB - Elsevier, New York NY VL - 48 IS - 4 SN - 1054-139X, 1054-139X KW - Sexual maturation Self-assessment Feasibility Children Adolescents KW - Assessment KW - Medical examinations KW - Feasibility KW - Maturation KW - Hair KW - Selfassessment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/870996035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=Feasibility+of+an+Audio+Computer-Assisted+Self-Interview+Method+to+Self-Assess+Sexual+Maturation&rft.au=Lamb%2C+Molly+M%3BBeers%2C+Lee%3BReed-Gillette%2C+Debra%3BMcDowell%2C+Margaret+A&rft.aulast=Lamb&rft.aufirst=Molly&rft.date=2011-04-01&rft.volume=48&rft.issue=4&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/10.1016%2Fj.jadohealth.2010.09.020 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-06-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JAHCD9 N1 - SubjectsTermNotLitGenreText - Selfassessment; Hair; Maturation; Feasibility; Assessment; Medical examinations DO - http://dx.doi.org/10.1016/j.jadohealth.2010.09.020 ER - TY - JOUR T1 - Library, Information Science & Technology Abstracts AN - 870995798; 201104626 AB - The Library, Information Science & Technology Abstracts (LISTA) database (http://www.libraryresearch.com) is reviewed. LISTA is a bibliographic database which indexes the library and information management literature. In 2009, EBSCO Publishing made LISTA available for free on its EBSCO host platform. LISTA is an excellent resource for technical services and in fact all librarians, both for researching a topic and for current awareness. Adapted from the source document. JF - Technical Services Quarterly AU - Landesman, Betty AD - National Institutes of Health Library, Bethesda, MD Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 246 EP - 247 PB - Taylor & Francis, Philadelphia PA VL - 28 IS - 2 SN - 0731-7131, 0731-7131 KW - Library and information science KW - Library and Information Science Abstracts KW - Online data bases KW - article KW - 13.23: ONLINE DATABASES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/870995798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Services+Quarterly&rft.atitle=Library%2C+Information+Science+%26amp%3B+Technology+Abstracts&rft.au=Landesman%2C+Betty&rft.aulast=Landesman&rft.aufirst=Betty&rft.date=2011-04-01&rft.volume=28&rft.issue=2&rft.spage=246&rft.isbn=&rft.btitle=&rft.title=Technical+Services+Quarterly&rft.issn=07317131&rft_id=info:doi/10.1080%2F07317131.2011.546292 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Online data bases; Library and information science; Library and Information Science Abstracts DO - http://dx.doi.org/10.1080/07317131.2011.546292 ER - TY - JOUR T1 - Semi-automatic semantic annotation of PubMed queries: A study on quality, efficiency, satisfaction AN - 869833406; 14608878 AB - Information processing algorithms require significant amounts of annotated data for training and testing. The availability of such data is often hindered by the complexity and high cost of production. In this paper, we investigate the benefits of a state-of-the-art tool to help with the semantic annotation of a large set of biomedical queries. Seven annotators were recruited to annotate a set of 10,000 PubMedA registered queries with 16 biomedical and bibliographic categories. About half of the queries were annotated from scratch, while the other half were automatically pre-annotated and manually corrected. The impact of the automatic pre-annotations was assessed on several aspects of the task: time, number of actions, annotator satisfaction, inter-annotator agreement, quality and number of the resulting annotations. The analysis of annotation results showed that the number of required hand annotations is 28.9% less when using pre-annotated results from automatic tools. As a result, the overall annotation time was substantially lower when pre-annotations were used, while inter-annotator agreement was significantly higher. In addition, there was no statistically significant difference in the semantic distribution or number of annotations produced when pre-annotations were used. The annotated query corpus is freely available to the research community. This study shows that automatic pre-annotations are found helpful by most annotators. Our experience suggests using an automatic tool to assist large-scale manual annotation projects. This helps speed-up the annotation time and improve annotation consistency while maintaining high quality of the final annotations. JF - Journal of Biomedical Informatics AU - Neveol, Aurelie AU - Islamaj Dogan, Rezarta AU - Lu, Zhiyong AD - National Center for Biotechnology Information, US National Library of Medicine, Bethesda, MD 20894, USA, zhiyong.lu@nih.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 310 EP - 318 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 44 IS - 2 SN - 1532-0464, 1532-0464 KW - Biotechnology and Bioengineering Abstracts KW - PubMed queries KW - Biomedical entities KW - Annotation standards KW - Annotation methods KW - Data processing KW - Information processing KW - Algorithms KW - Statistical analysis KW - Hand KW - Bioinformatics KW - Semantics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869833406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Informatics&rft.atitle=Semi-automatic+semantic+annotation+of+PubMed+queries%3A+A+study+on+quality%2C+efficiency%2C+satisfaction&rft.au=Neveol%2C+Aurelie%3BIslamaj+Dogan%2C+Rezarta%3BLu%2C+Zhiyong&rft.aulast=Neveol&rft.aufirst=Aurelie&rft.date=2011-04-01&rft.volume=44&rft.issue=2&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Informatics&rft.issn=15320464&rft_id=info:doi/10.1016%2Fj.jbi.2010.11.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Data processing; Information processing; Statistical analysis; Algorithms; Hand; Bioinformatics; Semantics DO - http://dx.doi.org/10.1016/j.jbi.2010.11.001 ER - TY - JOUR T1 - Hypertension with elevated levels of oxidized low-density lipoprotein and anticardiolipin antibody in the circulation of premenopausal Indian women chronically exposed to biomass smoke during cooking AN - 869799045; 14519777 AB - This study aims to investigate whether indoor air pollution (IAP) from biomass fuel use was associated with hypertension, platelet hyperactivity, and elevated levels of oxidized low-density lipoprotein (oxLDL) and anticardiolipin antibody (aCL). We enrolled 244 biomass fuel-using (median age 34year) and 236 age-matched control women who cooked with liquefied petroleum gas (LPG). Enzyme-linked immunosorbent assay was used to measure oxLDL in plasma and aCL in serum, flow cytometry for P-selectin expression on platelet and reactive oxygen species (ROS) generation by leukocytes, aggregometry for platelet aggregation, spectrophotometry for superoxide dismutase (SOD) in erythrocytes, and laser photometer for particulate matter <10 and 2.5 mu m in diameter (PM10 and PM2.5, respectively) in cooking areas. Biomass users had three times more particulate pollution in kitchen, had higher prevalence of hypertension (29.5 vs. 11.0% in control, P<0.05), elevated oxLDL (170.6 vs. 45.9U/l; P<0.001), platelet P-selectin expression (9.1% vs. 2.4%), platelet aggregation (23.2 vs. 15.9Ohm), raised aCL IgG (28.7% vs. 2.1%), IgM (8.6% of vs. 0.4%), and ROS (44%) but depleted (13%) SOD. After controlling potential confounders, the changes were positively associated with PM10 and PM2.5 in indoor air, suggesting a positive association between IAP and increased cardiovascular risk. The study showing high risk of developing cardiovascular diseases (CVD) among poor, underprivileged women in their reproductive ages in rural India is important from public health perspectives. It may motivate the government and the regulatory agencies of the country to take a serious note of the indoor air pollution (IAP) from biomass fuel use as it threatens the health of millions of women, children, and the elderly who mostly stay indoor. We hope the findings will strengthen the demand for setting up a standard for indoor air quality in the country in the line of national ambient air quality standard. The findings may also inspire the authorities to take measures for the reduction in IAP by improving housing, kitchen ventilation, and cook stoves. Moreover, the parameters used in this study can be utilized for large, population-based studies to identify women at a higher risk of developing CVD so that medical intervention can be taken at the formative stage of a disease. JF - Indoor Air AU - Dutta, A AU - Mukherjee, B AU - Das, D AU - Banerjee, A AU - Ray, M R AD - Department of Experimental Hematology, Chittaranjan National Cancer Institute, Kolkata, India Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 165 EP - 176 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 21 IS - 2 SN - 0905-6947, 0905-6947 KW - Pollution Abstracts; Biotechnology and Bioengineering Abstracts KW - Age KW - Platelet aggregation KW - Indoor air pollution KW - Fuels KW - Erythrocytes KW - P-selectin KW - Particulates KW - India KW - IAP protein KW - Flow cytometry KW - Reactive oxygen species KW - Superoxide dismutase KW - Risk factors KW - Cooking KW - Geriatrics KW - cooking KW - Particle size KW - Biomass KW - Kitchens KW - Air pollution KW - Smoke KW - hypertension KW - Lipoproteins KW - cardiolipin KW - Cardiovascular diseases KW - Indoor environments KW - Hypertension KW - W 30950:Waste Treatment & Pollution Clean-up KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869799045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+Air&rft.atitle=Hypertension+with+elevated+levels+of+oxidized+low-density+lipoprotein+and+anticardiolipin+antibody+in+the+circulation+of+premenopausal+Indian+women+chronically+exposed+to+biomass+smoke+during+cooking&rft.au=Dutta%2C+A%3BMukherjee%2C+B%3BDas%2C+D%3BBanerjee%2C+A%3BRay%2C+M+R&rft.aulast=Dutta&rft.aufirst=A&rft.date=2011-04-01&rft.volume=21&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Indoor+Air&rft.issn=09056947&rft_id=info:doi/10.1111%2Fj.1600-0668.2010.00694.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Document feature - figure 3 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Platelet aggregation; Fuels; Erythrocytes; P-selectin; Biomass; Kitchens; Smoke; Flow cytometry; IAP protein; Air pollution; Reactive oxygen species; Superoxide dismutase; Risk factors; Cooking; Lipoproteins; Geriatrics; cardiolipin; Cardiovascular diseases; Hypertension; Particle size; Age; Indoor air pollution; hypertension; cooking; Particulates; Indoor environments; India DO - http://dx.doi.org/10.1111/j.1600-0668.2010.00694.x ER - TY - JOUR T1 - Adding the Female Condom to HIV Prevention Interventions for Women with Severe Mental Illness: A Pilot Test AN - 869582012; 14526077 AB - We evaluated the efficacy of a gender-specific intervention to reduce sexual risk behaviors by introducing female-initiated methods to urban women with severe mental illness. Seventy-nine women received 10 sessions of an HIV prevention intervention or a control intervention. The primary outcome was unprotected oral, anal, or vaginal intercourse, expressed using the Vaginal Episode Equivalent (VEE) score. Knowledge and use of the female condom were also assessed. Women in the HIV prevention intervention showed a three-fold reduction in the VEE score at the 3-month follow-up compared to the control group, but the difference was not significant. These women were significantly more likely to know about female condoms, have inserted one and used it with a sexual partner at the 3-month follow-up and to have inserted it at 6months compared to controls. The female condom may be a useful addition, for a subset of women with SMI, to comprehensive HIV prevention programs. JF - Community Mental Health Journal AU - Collins, Pamela Y AU - Unger, Hella AU - Putnins, Susan AU - Crawford, Natalie AU - Dutt, Ragini AU - Hoffer, Marcela AD - Columbia University, New York, NY, USA, Pamela.Collins@nih.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 143 EP - 155 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 47 IS - 2 SN - 0010-3853, 0010-3853 KW - Health & Safety Science Abstracts; Risk Abstracts KW - sexual behavior KW - Human immunodeficiency virus KW - intervention KW - Gender KW - condoms KW - prevention KW - Females KW - mental disorders KW - H 11000:Diseases/Injuries/Trauma KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869582012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+Mental+Health+Journal&rft.atitle=Adding+the+Female+Condom+to+HIV+Prevention+Interventions+for+Women+with+Severe+Mental+Illness%3A+A+Pilot+Test&rft.au=Collins%2C+Pamela+Y%3BUnger%2C+Hella%3BPutnins%2C+Susan%3BCrawford%2C+Natalie%3BDutt%2C+Ragini%3BHoffer%2C+Marcela&rft.aulast=Collins&rft.aufirst=Pamela&rft.date=2011-04-01&rft.volume=47&rft.issue=2&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Community+Mental+Health+Journal&rft.issn=00103853&rft_id=info:doi/10.1007%2Fs10597-010-9302-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - sexual behavior; Human immunodeficiency virus; intervention; Gender; prevention; condoms; Females; mental disorders DO - http://dx.doi.org/10.1007/s10597-010-9302-8 ER - TY - JOUR T1 - Characterization and Acceptor Preference of a Soluble Meningococcal Group C Polysialyltransferase AN - 869576781; 14584048 AB - Vaccines against Neisseria meningitidis group C are based on its -2,9-linked polysialic acid capsular polysaccharide. This polysialic acid expressed on the surface of N. meningitidis and in the absence of specific antibody serves to evade host defense mechanisms. The polysialyltransferase (PST) that forms the group C polysialic acid (NmC PST) is located in the cytoplasmic membrane. Until recently, detailed characterization of bacterial polysialyltransferases has been hampered by a lack of availability of soluble enzyme preparations. We have constructed chimeras of the group C polysialyltransferase that catalyzes the formation -2,9-polysialic acid as a soluble enzyme. We used site-directed mutagenesis to determine the region of the enzyme necessary for synthesis of the -2,9 linkage. A chimera of NmB and NmC PSTs containing only amino acids 1 to 107 of the NmB polysialyltransferase catalyzed the synthesis of -2,8-polysialic acid. The NmC polysialyltransferase requires an exogenous acceptor for catalytic activity. While it requires a minimum of a disialylated oligosaccharide to catalyze transfer, it can form high-molecular-weight -2,9-polysialic acid in a nonprocessive fashion when initiated with an -2,8-polysialic acid acceptor. De novo synthesis in vivo requires an endogenous acceptor. We attempted to reconstitute de novo activity of the soluble group C polysialyltransferase with membrane components. We found that an acapsular mutant with a defect in the polysialyltransferase produces outer membrane vesicles containing an acceptor for the -2,9-polysialyltransferase. This acceptor is an amphipathic molecule and can be elongated to produce polysialic acid that is reactive with group C-specific antibody. JF - Journal of Bacteriology AU - Peterson, Dwight C AU - Arakere, Gayathri AU - Vionnet, Justine AU - McCarthy, Pumtiwitt C AU - Vann, Willie F AD - Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Bethesda, Maryland 20892, wvann@helix.nih.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 1576 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 193 IS - 7 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Site-directed mutagenesis KW - Amino acids KW - oligosaccharides KW - Outer membranes KW - Enzymes KW - Neisseria meningitidis KW - Chimeras KW - Antibodies KW - polysialyltransferase KW - Cytoplasmic membranes KW - Membrane vesicles KW - Defense mechanisms KW - Vaccines KW - polysialic acid KW - Capsular polysaccharides KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869576781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Characterization+and+Acceptor+Preference+of+a+Soluble+Meningococcal+Group+C+Polysialyltransferase&rft.au=Peterson%2C+Dwight+C%3BArakere%2C+Gayathri%3BVionnet%2C+Justine%3BMcCarthy%2C+Pumtiwitt+C%3BVann%2C+Willie+F&rft.aulast=Peterson&rft.aufirst=Dwight&rft.date=2011-04-01&rft.volume=193&rft.issue=7&rft.spage=1576&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.00924-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Number of references - 34 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Site-directed mutagenesis; oligosaccharides; Amino acids; Outer membranes; Enzymes; Chimeras; Antibodies; polysialyltransferase; Membrane vesicles; Cytoplasmic membranes; polysialic acid; Vaccines; Defense mechanisms; Capsular polysaccharides; Neisseria meningitidis DO - http://dx.doi.org/10.1128/JB.00924-10 ER - TY - JOUR T1 - Postdiagnosis diet quality, the combination of diet quality and recreational physical activity, and prognosis after early-stage breast cancer AN - 869573814; 14541869 AB - Objective: To investigate, among women with breast cancer, how postdiagnosis diet quality and the combination of diet quality and recreational physical activity are associated with prognosis. Methods: This multiethnic, prospective observational cohort included 670 women diagnosed with local or regional breast cancer. Thirty months after diagnosis, women completed self-report assessments on diet and physical activity and were followed for 6years. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals for death from any cause and breast cancer death. Results: Women consuming better-quality diets, as defined by higher Healthy Eating Index-2005 scores, had a 60% reduced risk of death from any cause (HR sub(Q4:Q1): 0.40, 95% CI: 0.17, 0.94) and an 88% reduced risk of death from breast cancer (HR sub(Q4:Q1): 0.12, 95% CI: 0.02, 0.99). Compared with inactive survivors consuming poor-quality diets, survivors engaging in any recreational physical activity and consuming better-quality diets had an 89% reduced risk of death from any cause (HR: 0.11, 95% CI: 0.04, 0.36) and a 91% reduced risk of death from breast cancer (HR: 0.09, 95% CI: 0.01, 0.89). Associations observed were independent of obesity status. Conclusion: Women diagnosed with localized or regional breast cancer may improve prognosis by adopting better-quality dietary patterns and regular recreational physical activity. Lifestyle interventions emphasizing postdiagnosis behavior changes are advisable in breast cancer survivors. JF - Cancer Causes & Control AU - George, Stephanie M AU - Irwin, Melinda L AU - Smith, Ashley W AU - Neuhouser, Marian L AU - Reedy, Jill AU - McTiernan, Anne AU - Alfano, Catherine M AU - Bernstein, Leslie AU - Ulrich, Cornelia M AU - Baumgartner, Kathy B AU - Moore, Steven C AU - Albanes, Demetrius AU - Mayne, Susan T AU - Gail, Mitchell H AU - Ballard-Barbash, Rachel AD - Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD, USA, materess@mail.nih.gov materess@mail.nih.gov materess@mail.nih.gov materess@mail.nih.gov materess@mail.nih.gov materess@mail.nih.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 589 EP - 598 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 22 IS - 4 SN - 0957-5243, 0957-5243 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Diets KW - Mortality KW - obesity KW - Cancer KW - risk reduction KW - Recreation areas KW - intervention KW - Breast cancer KW - physical activity KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869573814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Postdiagnosis+diet+quality%2C+the+combination+of+diet+quality+and+recreational+physical+activity%2C+and+prognosis+after+early-stage+breast+cancer&rft.au=George%2C+Stephanie+M%3BIrwin%2C+Melinda+L%3BSmith%2C+Ashley+W%3BNeuhouser%2C+Marian+L%3BReedy%2C+Jill%3BMcTiernan%2C+Anne%3BAlfano%2C+Catherine+M%3BBernstein%2C+Leslie%3BUlrich%2C+Cornelia+M%3BBaumgartner%2C+Kathy+B%3BMoore%2C+Steven+C%3BAlbanes%2C+Demetrius%3BMayne%2C+Susan+T%3BGail%2C+Mitchell+H%3BBallard-Barbash%2C+Rachel&rft.aulast=George&rft.aufirst=Stephanie&rft.date=2011-04-01&rft.volume=22&rft.issue=4&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9732-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diets; risk reduction; Mortality; Recreation areas; intervention; obesity; Breast cancer; physical activity; Cancer DO - http://dx.doi.org/10.1007/s10552-011-9732-9 ER - TY - JOUR T1 - Ethanol Production from Residual Wood Chips of Cellulose Industry: Acid Pretreatment Investigation, Hemicellulosic Hydrolysate Fermentation, and Remaining Solid Fraction Fermentation by SSF Process AN - 869572657; 14435792 AB - Current research indicates the ethanol fuel production from lignocellulosic materials, such as residual wood chips from the cellulose industry, as new emerging technology. This work aimed at evaluating the ethanol production from hemicellulose of eucalyptus chips by diluted acid pretreatment and the subsequent fermentation of the generated hydrolysate by a flocculating strain of Pichia stipitis. The remaining solid fraction generated after pretreatment was subjected to enzymatic hydrolysis, which was carried out simultaneously with glucose fermentation [saccharification and fermentation (SSF) process] using a strain of Saccharomyces cerevisiae. The acid pretreatment was evaluated using a central composite design for sulfuric acid concentration (1.0-4.0v/v) and solid to liquid ratio (1:2-1:4, grams to milliliter) as independent variables. A maximum xylose concentration of 50g/L was obtained in the hemicellulosic hydrolysate. The fermentation of hemicellulosic hydrolysate and the SSF process were performed in bioreactors and the final ethanol concentrations of 15.3g/L and 28.7g/L were obtained, respectively. JF - Applied Biochemistry and Biotechnology AU - Silva, Neumara Luci Conceicao AU - Betancur, Gabriel Jaime Vargas AU - Vasquez, Mariana Penuela AU - Barros Gomes, Edelvio AU - Pereira, Nei AD - Biochemical Engineering Department, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, 21945-970, Brazil, nei@eq.ufrj.br Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 928 EP - 936 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 163 IS - 7 SN - 0273-2289, 0273-2289 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - Xylose KW - Fermentation KW - Fuels KW - Cellulose KW - Glucose KW - Hydrolysis KW - Eucalyptus KW - Saccharomyces cerevisiae KW - hemicellulose KW - Pichia stipitis KW - Bioreactors KW - Sulfuric acid KW - Hydrolysates KW - Ethanol KW - W 30950:Waste Treatment & Pollution Clean-up KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869572657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Biochemistry+and+Biotechnology&rft.atitle=Ethanol+Production+from+Residual+Wood+Chips+of+Cellulose+Industry%3A+Acid+Pretreatment+Investigation%2C+Hemicellulosic+Hydrolysate+Fermentation%2C+and+Remaining+Solid+Fraction+Fermentation+by+SSF+Process&rft.au=Silva%2C+Neumara+Luci+Conceicao%3BBetancur%2C+Gabriel+Jaime+Vargas%3BVasquez%2C+Mariana+Penuela%3BBarros+Gomes%2C+Edelvio%3BPereira%2C+Nei&rft.aulast=Silva&rft.aufirst=Neumara+Luci&rft.date=2011-04-01&rft.volume=163&rft.issue=7&rft.spage=928&rft.isbn=&rft.btitle=&rft.title=Applied+Biochemistry+and+Biotechnology&rft.issn=02732289&rft_id=info:doi/10.1007%2Fs12010-010-9096-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2013-12-04 N1 - SubjectsTermNotLitGenreText - Xylose; Fermentation; Fuels; Bioreactors; Cellulose; Sulfuric acid; Glucose; Hydrolysis; Hydrolysates; hemicellulose; Ethanol; Pichia stipitis; Saccharomyces cerevisiae; Eucalyptus DO - http://dx.doi.org/10.1007/s12010-010-9096-8 ER - TY - JOUR T1 - Adeno-Associated Virus Serotype 8 Gene Transfer Rescues a Neonatal Lethal Murine Model of Propionic Acidemia AN - 867750383; 14806258 AB - Propionic acidemia (PA) is an autosomal recessive disorder of metabolism caused by a deficiency of propionyl-coenzyme A carboxylase (PCC). Despite optimal dietary and cofactor therapy, PA patients still suffer from lethal metabolic instability and experience multisystemic complications. A murine model of PA (Pcca super(-/-)) of animals that uniformly die within the first 48 hr of life was used to determine the efficacy of adeno-associated viral (AAV) gene transfer as a potential therapy for PA. An AAV serotype 8 (AAV8) vector was engineered to express the human PCCA cDNA and delivered to newborn mice via an intrahepatic injection. Greater than 64% of the Pcca super(-/-) mice were rescued after AAV8-mediated gene transfer and survived until day of life 16 or beyond. Western analysis of liver extracts showed that PCC was completely absent from Pcca super(-/-) mice but was restored to greater than wild-type levels after AAV gene therapy. The treated Pcca super(-/-) mice also exhibited markedly reduced plasma levels of 2-methylcitrate compared with the untreated Pcca super(-/-) mice, which indicates significant PCC enzymatic activity was provided by gene transfer. At the time of this report, the oldest treated Pcca super(-/-) mice are over 6 months of age. In summary, AAV gene delivery of PCCA effectively rescues Pcca super(-/-) mice from neonatal lethality and substantially ameliorates metabolic markers of the disease. These experiments demonstrate a gene transfer approach using AAV8 that might be used as a treatment for PA, a devastating and often lethal disorder desperately in need of new therapeutic options. JF - Human Gene Therapy AU - Chandler, R J AU - Chandrasekaran, S AU - Carrillo-Carrasco, N AU - Senac, J S AU - Hofherr, SE AU - Barry, MA AU - Venditti, C P AD - Organic Acid Research Section Genetics and Molecular Biology Branch National Human Genome Research Institute National Institutes of Health Building 49, Room 4A18 Bethesda, MD 20892, USA, venditti@mail.nih.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 477 EP - 481 VL - 22 IS - 4 SN - 1043-0342, 1043-0342 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Age KW - Hereditary diseases KW - Serotypes KW - Gene therapy KW - Animal models KW - Adeno-associated virus KW - Expression vectors KW - Plasma levels KW - Cofactors KW - Lethality KW - Gene transfer KW - Liver KW - propionic acidemia KW - Neonates KW - Enzymatic activity KW - Metabolism KW - W 30905:Medical Applications KW - A 01490:Miscellaneous KW - G 07870:Mammals KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867750383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Adeno-Associated+Virus+Serotype+8+Gene+Transfer+Rescues+a+Neonatal+Lethal+Murine+Model+of+Propionic+Acidemia&rft.au=Chandler%2C+R+J%3BChandrasekaran%2C+S%3BCarrillo-Carrasco%2C+N%3BSenac%2C+J+S%3BHofherr%2C+SE%3BBarry%2C+MA%3BVenditti%2C+C+P&rft.aulast=Chandler&rft.aufirst=R&rft.date=2011-04-01&rft.volume=22&rft.issue=4&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2010.164 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Age; Serotypes; Hereditary diseases; Gene therapy; Animal models; Expression vectors; Plasma levels; Lethality; Cofactors; Gene transfer; propionic acidemia; Liver; Enzymatic activity; Neonates; Metabolism; Adeno-associated virus DO - http://dx.doi.org/10.1089/hum.2010.164 ER - TY - JOUR T1 - In silico analysis of the binding of agonists and blockers to the I22-adrenergic receptor AN - 867742920; 14604698 AB - Activation of G protein-coupled receptors (GPCRs) is a complex phenomenon. Here, we applied Induced Fit Docking (IFD) in tandem with linear discriminant analysis (LDA) to generate hypotheses on the conformational changes induced to the I22-adrenergic receptor by agonist binding, preliminary to the sequence of events that characterize activation of the receptor. This analysis, corroborated by a follow-up molecular dynamics study, suggested that agonists induce subtle movements to the fifth transmembrane domain (TM5) of the receptor. Furthermore, molecular dynamics also highlighted a correlation between movements of TM5 and the second extracellular loop (EL2), suggesting that freedom of motion of EL2 is required for the agonist-induced TM5 displacement. Importantly, we also showed that the IFD/LDA procedure can be used as a computational means to distinguish agonists from blockers on the basis of the differential conformational changes induced to the receptor. In particular, the two most predictive models obtained are based on the RMSD induced to Ser207 and on the counterclockwise rotation induced to TM5. JF - Journal of Molecular Graphics and Modelling AU - Vilar, Santiago AU - Karpiak, Joel AU - Berk, Barkin AU - Costanzi, Stefano AD - Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA, stefanoc@mail.nih.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 809 EP - 817 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 29 IS - 6 SN - 1093-3263, 1093-3263 KW - Biotechnology and Bioengineering Abstracts KW - G protein-coupled receptor KW - Agonists KW - Blockers KW - Induced Fit KW - Docking KW - Linear discriminant analysis KW - Molecular dynamics KW - double prime G protein-coupled receptors KW - Transmembrane domains KW - Computer applications KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867742920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Graphics+and+Modelling&rft.atitle=In+silico+analysis+of+the+binding+of+agonists+and+blockers+to+the+I22-adrenergic+receptor&rft.au=Vilar%2C+Santiago%3BKarpiak%2C+Joel%3BBerk%2C+Barkin%3BCostanzi%2C+Stefano&rft.aulast=Vilar&rft.aufirst=Santiago&rft.date=2011-04-01&rft.volume=29&rft.issue=6&rft.spage=809&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Graphics+and+Modelling&rft.issn=10933263&rft_id=info:doi/10.1016%2Fj.jmgm.2011.01.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - double prime G protein-coupled receptors; Molecular dynamics; Computer applications; Transmembrane domains; Models DO - http://dx.doi.org/10.1016/j.jmgm.2011.01.005 ER - TY - JOUR T1 - A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background. AN - 863899669; 20739907 AB - The arylamine N-acetyltransferase 2 (NAT2) slow acetylation phenotype is an established risk factor for urinary bladder cancer. We reported earlier on this risk association using NAT2 phenotypic categories inferred from NAT2 haplotypes based on seven single nucleotide polymorphisms (SNPs) in a study in Spain. In a subsequent genome-wide scan, we have identified a single common tag SNP (rs1495741) located in the 3' end of NAT2 that is also associated with bladder cancer risk. The aim of this report is to evaluate the agreement between the common tag SNP and the 7-SNP NAT2 inferred phenotype. The agreement between the 7-SNP NAT2 inferred phenotype and the tag SNP, rs1495741, was initially assessed in 2174 individuals from the Spanish Bladder Cancer Study (SBCS), and confirmed in a subset of individuals from the Main and Vermont component the New England Bladder Cancer Study (NEBCS). We also investigated the association of rs1495741 genotypes with NAT2 catalytic activity in cryopreserved hepatocytes from 154 individuals of European background. We observed very strong agreement between rs1495741 and the 7-SNP inferred NAT2 phenotype: sensitivity and specificity for the NAT2 slow phenotype was 99 and 95%, respectively. Our findings were replicated in an independent population from the NEBCS. Estimates for the association between NAT2 slow phenotype and bladder cancer risk in the SBCS and its interaction with cigarette smoking were comparable for the 7-SNP inferred NAT2 phenotype and rs1495741. In addition, rs1495741 genotypes were strongly related to NAT2 activity measured in hepatocytes (P<0.0001). A novel NAT2 tag SNP (rs1495741) predicts with high accuracy the 7-SNP inferred NAT2 phenotype, and thus can be used as a sole marker in pharmacogenetic or epidemiological studies of populations of European background. These findings illustrate the utility of tag SNPs, often used in genome-wide association studies (GWAS), to identify novel phenotypic markers. Further studies are required to determine the functional implications of rs1495741 and the structure and evolution of the haplotype on which it resides. JF - Pharmacogenetics and genomics AU - García-Closas, Montserrat AU - Hein, David W AU - Silverman, Debra AU - Malats, Núria AU - Yeager, Meredith AU - Jacobs, Kevin AU - Doll, Mark A AU - Figueroa, Jonine D AU - Baris, Dalsu AU - Schwenn, Molly AU - Kogevinas, Manolis AU - Johnson, Alison AU - Chatterjee, Nilanjan AU - Moore, Lee E AU - Moeller, Timothy AU - Real, Francisco X AU - Chanock, Stephen AU - Rothman, Nathaniel AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA. Montse.GarciaClosas@icr.ac.uk Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 231 EP - 236 VL - 21 IS - 4 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - NAT2 protein, human KW - Index Medicus KW - Genotype KW - Haplotypes KW - Spain KW - Humans KW - New England KW - Case-Control Studies KW - European Continental Ancestry Group -- genetics KW - Vermont KW - Phenotype KW - Polymorphism, Single Nucleotide -- genetics KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863899669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenetics+and+genomics&rft.atitle=A+single+nucleotide+polymorphism+tags+variation+in+the+arylamine+N-acetyltransferase+2+phenotype+in+populations+of+European+background.&rft.au=Garc%C3%ADa-Closas%2C+Montserrat%3BHein%2C+David+W%3BSilverman%2C+Debra%3BMalats%2C+N%C3%BAria%3BYeager%2C+Meredith%3BJacobs%2C+Kevin%3BDoll%2C+Mark+A%3BFigueroa%2C+Jonine+D%3BBaris%2C+Dalsu%3BSchwenn%2C+Molly%3BKogevinas%2C+Manolis%3BJohnson%2C+Alison%3BChatterjee%2C+Nilanjan%3BMoore%2C+Lee+E%3BMoeller%2C+Timothy%3BReal%2C+Francisco+X%3BChanock%2C+Stephen%3BRothman%2C+Nathaniel&rft.aulast=Garc%C3%ADa-Closas&rft.aufirst=Montserrat&rft.date=2011-04-01&rft.volume=21&rft.issue=4&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Pharmacogenetics+and+genomics&rft.issn=1744-6880&rft_id=info:doi/10.1097%2FFPC.0b013e32833e1b54 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-22 N1 - Date created - 2011-03-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):29-42 [10667461] Carcinogenesis. 2011 Feb;32(2):182-9 [21037224] Pharmacogenetics. 2001 Apr;11(3):207-15 [11337936] Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1543-6 [15342459] Pharmacogenetics. 1992 Jun;2(3):116-27 [1306111] Hum Mol Genet. 1994 May;3(5):729-34 [8081359] Lancet. 2005 Aug 20-26;366(9486):649-59 [16112301] Oncogene. 2006 Mar 13;25(11):1649-58 [16550165] Int J Epidemiol. 2007 Feb;36(1):23-8 [17510073] Carcinogenesis. 2007 Aug;28(8):1665-71 [17434923] Curr Drug Metab. 2008 Jul;9(6):471-86 [18680467] Expert Opin Drug Metab Toxicol. 2009 Apr;5(4):353-66 [19379125] J Natl Cancer Inst. 2009 Nov 18;101(22):1553-61 [19917915] DNA Cell Biol. 2009 Jan;28(1):3-7 [18821846] J Pharmacol Exp Ther. 2010 Aug;334(2):540-4 [20430842] Nat Genet. 2010 Nov;42(11):978-84 [20972438] Anal Biochem. 2001 Jan 1;288(1):106-8 [11141315] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/FPC.0b013e32833e1b54 ER - TY - JOUR T1 - Discovering natural product modulators to overcome multidrug resistance in cancer chemotherapy. AN - 863428159; 21118092 AB - Multidrug resistance caused by the overexpression of ABC drug transporters is a major obstacle in clinical cancer chemotherapy. For several years, it appeared that direct inhibition of ABC transporters would be the cheapest and most efficient way to combat this problem. Unfortunately, progress in finding a potent, selective inhibitor to modulate ABC transporters and restore drug sensitivity in multidrug-resistant cancer cells has been slow and challenging. Candidate drugs should ideally be selective, potent and relatively non-toxic. Many researchers in recent years have turned their attention to utilizing natural products as the building blocks for the development of the next generation of inhibitors, especially after the disappointing results obtained from inhibitors of the first three generations at the clinical trial stage. The first step is to discover natural substances (distinct from the first three generation inhibitors) that are potent, selective and relatively non-toxic in order to be used clinically. Here, we present a brief overview of the prospect of using natural products to modulate the function of ABC drug transporters clinically and their impact on human physiology and pharmacology. JF - Current pharmaceutical biotechnology AU - Wu, Chung-Pu AU - Ohnuma, Shinobu AU - Ambudkar, Suresh V AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 609 EP - 620 VL - 12 IS - 4 KW - Biological Products KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Drug Discovery KW - Biological Products -- therapeutic use KW - Biological Products -- isolation & purification KW - Neoplasms -- drug therapy KW - ATP-Binding Cassette Transporters -- genetics KW - Drug Resistance, Multiple -- drug effects KW - ATP-Binding Cassette Transporters -- antagonists & inhibitors KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863428159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+pharmaceutical+biotechnology&rft.atitle=Discovering+natural+product+modulators+to+overcome+multidrug+resistance+in+cancer+chemotherapy.&rft.au=Wu%2C+Chung-Pu%3BOhnuma%2C+Shinobu%3BAmbudkar%2C+Suresh+V&rft.aulast=Wu&rft.aufirst=Chung-Pu&rft.date=2011-04-01&rft.volume=12&rft.issue=4&rft.spage=609&rft.isbn=&rft.btitle=&rft.title=Current+pharmaceutical+biotechnology&rft.issn=1873-4316&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-29 N1 - Date created - 2011-04-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Planta Med. 2007 May;73(5):444-50 [17566147] Adv Exp Med Biol. 2007;595:77-103 [17569206] Adv Exp Med Biol. 2007;595:127-48 [17569208] Adv Exp Med Biol. 2007;595:471-80 [17569225] J Surg Oncol. 2007 Jul 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Ther. 2006 May;317(2):850-7 [16439618] Mol Pharm. 2006 Jan-Feb;3(1):3-25 [16686365] Am J Chin Med. 2006;34(3):493-502 [16710898] Biochim Biophys Acta. 1999 Dec 6;1461(2):359-76 [10581367] Cancer Res. 2000 Jan 1;60(1):47-50 [10646850] Anticancer Res. 1999 Nov-Dec;19(6B):5229-33 [10697540] Am J Health Syst Pharm. 2000 Jun 15;57(12):1121-2 [10911509] Med Res Rev. 2000 Sep;20(5):323-49 [10934347] Br J Dermatol. 2000 Nov;143(5):937-49 [11069500] Clin Cancer Res. 2001 Jan;7(1):145-52 [11205902] Mol Pharmacol. 2001 May;59(5):1171-80 [11306701] Anticancer Res. 2001 Jul-Aug;21(4B):2895-900 [11712783] Nat Rev Cancer. 2002 Jan;2(1):48-58 [11902585] Adv Drug Deliv Rev. 2002 Mar 31;54(3):315-28 [11922950] Leukemia. 2002 May;16(5):833-9 [11986944] Biochem Biophys Res Commun. 2002 Jul 26;295(4):832-40 [12127970] Leukemia. 2002 Aug;16(8):1443-7 [12145683] Biochem Pharmacol. 2002 Aug 15;64(4):573-82 [12167476] Med Res Rev. 2002 Sep;22(5):512-29 [12210557] Biochem Pharmacol. 2003 Jan 1;65(1):75-82 [12473381] Curr Opin Investig Drugs. 2002 Nov;3(11):1652-9 [12476969] J Pharm Pharm Sci. 2009;12(1):46-78 [19470292] Eur J Pharm Sci. 2009 Jun 28;37(3-4):223-30 [19491009] Mol Interv. 2009 Jun;9(3):136-45 [19592674] Altern Med Rev. 2009 Jun;14(2):141-53 [19594223] Nat Prod Rep. 2009 Aug;26(8):1001-43 [19636448] J Nutr. 2009 Sep;139(9):1824S-31S [19640966] J Agric Food Chem. 2009 Sep 23;57(18):8142-60 [19719126] Biochem Pharmacol. 2009 Nov 1;78(9):1272-8 [19591810] Nutr Cancer. 2009;61(5):587-97 [19838932] Curr Mol Pharmacol. 2008 Jun;1(2):93-105 [19079736] Phytother Res. 2010 Jan;24(1):146-9 [19548284] Toxicology. 2010 Nov 28;278(1):88-100 [19903510] Cancer Chemother Pharmacol. 2010 Jan;65(2):335-46 [19495754] Biochem Biophys Res Commun. 2004 Apr 23;317(1):269-75 [15047179] Gynecol Oncol. 2004 Apr;93(1):98-106 [15047220] Eur J Haematol. 2004 May;72(5):314-21 [15059065] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification and evaluation of soft coral diterpenes as inhibitors of HIF-2 alpha induced gene expression AN - 862783521; 14611282 AB - Kidney cancer was the cause of almost 13,000 deaths in the United States in 2009. Loss of function of the VHL tumor suppressor gene (von Hippel-Lindau disease) dramatically increases the risk of developing clear cell kidney cancer. The VHL protein is best understood for its regulation of hypoxia inducible factor (HIF). HIF responds to changes in oxygen levels in the cell and is responsible for mediating the transcriptional response to hypoxia. Of the three known HIF alpha gene products, HIF-2 alpha appears to play a fundamental role in renal carcinoma. A high throughput screen was developed to identify small molecule inhibitors of HIF-2 gene expression. The screen was performed and yielded 153 confirmed active natural product extracts. Three of the active extracts were from marine soft corals of the order Alcyonacea: Sarcophyton sp., Lobophytum sarcophytoides and Asterospicularia laurae. Bioassay-guided fractionation led to the isolation of two new cembrane diterpenes, (4Z,8S*,9R*,12E,14E)-9-hydroxy-1-(prop-1-en-2-yl)-8,12-dimethyl-ox a bicyclo[9.3.2]-hexadeca-4,12,14-trien-18-one ( 1), and (1E,3E,7R*,8R*,11E)-1-(2-methoxypropan-2-yl)-4,8,12-trimethyloxabi c yclo[12.1.0]-pentadeca-1,3,11-triene ( 7), as well as eight known compounds, 2- 6 and 8- 10. JF - Bioorganic and Medicinal Chemistry Letters AU - Grkovic, Tanja AU - Whitson, Emily L AU - Rabe, Daniel C AU - Gardella, Roberta S AU - Bottaro, Donald P AU - Linehan, WMarston AU - McMahon, James B AU - Gustafson, Kirk R AU - McKee, Tawnya C AD - Molecular Targets Laboratory, NCI-Frederick, Frederick, MD 21702, United States, mckeeta@mail.nih.gov Y1 - 2011/04/01/ PY - 2011 DA - 2011 Apr 01 SP - 2113 EP - 2115 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 21 IS - 7 SN - 0960-894X, 0960-894X KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Clear cells KW - Corals KW - Gene expression KW - Hypoxia KW - Oxygen KW - Transcription KW - VHL protein KW - Von Hippel-Lindau disease KW - diterpenes KW - natural products KW - renal cell carcinoma KW - Alcyonacea KW - Sarcophyton KW - Lobophytum KW - W 30915:Pharmaceuticals & Vaccines KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862783521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Identification+and+evaluation+of+soft+coral+diterpenes+as+inhibitors+of+HIF-2+alpha+induced+gene+expression&rft.au=Grkovic%2C+Tanja%3BWhitson%2C+Emily+L%3BRabe%2C+Daniel+C%3BGardella%2C+Roberta+S%3BBottaro%2C+Donald+P%3BLinehan%2C+WMarston%3BMcMahon%2C+James+B%3BGustafson%2C+Kirk+R%3BMcKee%2C+Tawnya+C&rft.aulast=Grkovic&rft.aufirst=Tanja&rft.date=2011-04-01&rft.volume=21&rft.issue=7&rft.spage=2113&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2011.01.127 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2012-06-29 N1 - SubjectsTermNotLitGenreText - Gene expression; Oxygen; renal cell carcinoma; Hypoxia; diterpenes; Von Hippel-Lindau disease; Clear cells; Transcription; natural products; Corals; VHL protein; Sarcophyton; Alcyonacea; Lobophytum DO - http://dx.doi.org/10.1016/j.bmcl.2011.01.127 ER - TY - JOUR T1 - Personality profiles and the "Russian soul": literary and scholarly views evaluated AN - 861589138; 4184752 AB - Many domestic and foreign observers have claimed that Russians have a unique constellation of personality traits that mirrors their distinctive historical and cultural experience. To examine the hypothesized uniqueness of Russian personality, members of the Russian Character and Personality Survey collected data from 39 samples in 33 administrative areas of the Russian Federation. Respondents ( N = 7,065) identified an ethnically Russian adult or college-aged man or woman whom they knew well and rated the target using the Russian observer-rating version of the Revised NEO Personality Inventory. The mean personality profile of Russians was very similar to the international average based on 50 different countries, debunking the myth of a unique Russian soul. The small variations from world norms did not converge with depictions of Russian national character in fiction and the scholarly literature. New items intended to capture distinctive, emic aspects of Russian personality provided no new information beyond the familiar Big Five dimensions. Religion, ethnicity, and beliefs about the uniqueness of the Russian character and the malleability of personality traits had little effect on personality ratings. Perceptions of the Russian soul do not seem to be based on the personality traits of Russians. JF - Journal of cross-cultural psychology AU - Allik, Jüri AU - Realo, Anu AU - Mõttus, René AU - Pullmann, Helle AU - Trifonova, Anastasia AU - McCrae, Robert R AU - Yurina, Alla A AU - Shebanets, Elena Y AU - Fadina, Anelina G AU - Tikhonova, Elenora V AU - Troitskaya, Irina Y AU - Fatyhova, Rimma M AU - Petrova, Irina F AU - Tudupova, Tuyana T AU - Tsiring, Diana A AU - Panfilov, Aleksey N AU - L'dokova, Galya M AU - Aristova, Irina L AU - Mescheryakov, Boris G AU - Zorina, Julia AU - Yuschenkova, Darya V AU - Fotekova, Tatiana A AU - Osmina, Elena V AU - Vavilkina, Natalya G AU - Skhorohodova, Nina Y AU - Zernova, Tatyana I AU - Dostovalov, Sergey G AU - Kadykova, Svetlana A AU - Korepanova, Inna A AU - Saharova, Anna AU - Naumov, Nikolai D AU - Snegireva, Tatyana V AU - Kuznetsov, Igor Y AU - Kuznetsova, Snezhana A AU - Rubtsova, Maria O AU - Filatova, Aleksandra F AU - Nechaeva, Tatyana M AU - Borisova, Svetlana N AU - Postnikova, Margarita I AU - Gluhanyuk, Natalya S AU - Dyachenko, Elena V AU - Fomina, Natalya A AU - Eromasova, Aleksandra A AU - Myshkina, Svetlana V AU - Rulina, Tatyana K AU - Yavkina, Elena V AU - Knyazev, Gennady G AU - Ryabichenko, Tatyana I AU - Demidova, Irina F AU - Uvarov, Evgeni A AU - Lopukhova, Olga G AU - Vasyagina, Natalya N AU - Leonenko, Natalya O AU - Arinin, Evgeni I AU - Lyapina, Anna A AU - Dulina, Nadezhda V AU - Poyarova, Tatyana A AU - Gaidar, Karina M AU - Baranov, Aleksandr A AU - Kozhevnikova, Oksana V AU - Kalinichenko, Olga V AU - Korneeva, Ekaterina E AD - University of Tartu ; National Institutes of Health, Baltimore ; Adyghe State University ; Astrakhan State University ; Arzamas State Pedagogical University ; Bashkir State Pedagogical University ; Buryat State University ; Chelyabinsk State University ; Elabuga State Pedagogical University ; Far Eastern National University ; International University of Nature, Society and Man "Dubna" ; Katanov State University ; Izhevsk State Techonlogical University ; Karelian State Pedagogical University ; Kuban State University of Physical Education, Sport and Tourism ; Kurgan State University ; Mari State University ; Moscow City University of Psychology and Education ; Nizhnevartovsk State Humanitarian University ; North-East State University ; Novosibirsk State Pedagogical University ; Omsk State Pedagogical University ; Orel State University ; Perm State University ; Pomor State University ; Russian State Professional Pedagogical University ; Ryazan State University ; Sakhalin State University ; Samara State Pedagogical University ; Russian Academy of Medical Sciences ; Taganrog Institute of Management and Economy ; Tambov State University ; Tatar State Humanitarian-Pedagogical University ; Ural State Pedagogical University ; Vladimir State University ; Volgograd Academy of Public Administration ; Volgograd State Technical University ; Vologda State Pedagogical University ; Voronezh State University ; Udmurt State University ; Ussuriysk State Pedagogical Institute ; Yaroslavl Demidov State University Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 372 EP - 389 VL - 42 IS - 3 SN - 0022-0221, 0022-0221 KW - Sociology KW - Comparative analysis KW - Evaluation KW - Fiction KW - Literature KW - Personality traits KW - Cross-cultural analysis KW - Russians KW - Personality KW - Mentality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/861589138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cross-cultural+psychology&rft.atitle=Personality+profiles+and+the+%22Russian+soul%22%3A+literary+and+scholarly+views+evaluated&rft.au=Allik%2C+J%C3%BCri%3BRealo%2C+Anu%3BM%C3%B5ttus%2C+Ren%C3%A9%3BPullmann%2C+Helle%3BTrifonova%2C+Anastasia%3BMcCrae%2C+Robert+R%3BYurina%2C+Alla+A%3BShebanets%2C+Elena+Y%3BFadina%2C+Anelina+G%3BTikhonova%2C+Elenora+V%3BTroitskaya%2C+Irina+Y%3BFatyhova%2C+Rimma+M%3BPetrova%2C+Irina+F%3BTudupova%2C+Tuyana+T%3BTsiring%2C+Diana+A%3BPanfilov%2C+Aleksey+N%3BL%27dokova%2C+Galya+M%3BAristova%2C+Irina+L%3BMescheryakov%2C+Boris+G%3BZorina%2C+Julia%3BYuschenkova%2C+Darya+V%3BFotekova%2C+Tatiana+A%3BOsmina%2C+Elena+V%3BVavilkina%2C+Natalya+G%3BSkhorohodova%2C+Nina+Y%3BZernova%2C+Tatyana+I%3BDostovalov%2C+Sergey+G%3BKadykova%2C+Svetlana+A%3BKorepanova%2C+Inna+A%3BSaharova%2C+Anna%3BNaumov%2C+Nikolai+D%3BSnegireva%2C+Tatyana+V%3BKuznetsov%2C+Igor+Y%3BKuznetsova%2C+Snezhana+A%3BRubtsova%2C+Maria+O%3BFilatova%2C+Aleksandra+F%3BNechaeva%2C+Tatyana+M%3BBorisova%2C+Svetlana+N%3BPostnikova%2C+Margarita+I%3BGluhanyuk%2C+Natalya+S%3BDyachenko%2C+Elena+V%3BFomina%2C+Natalya+A%3BEromasova%2C+Aleksandra+A%3BMyshkina%2C+Svetlana+V%3BRulina%2C+Tatyana+K%3BYavkina%2C+Elena+V%3BKnyazev%2C+Gennady+G%3BRyabichenko%2C+Tatyana+I%3BDemidova%2C+Irina+F%3BUvarov%2C+Evgeni+A%3BLopukhova%2C+Olga+G%3BVasyagina%2C+Natalya+N%3BLeonenko%2C+Natalya+O%3BArinin%2C+Evgeni+I%3BLyapina%2C+Anna+A%3BDulina%2C+Nadezhda+V%3BPoyarova%2C+Tatyana+A%3BGaidar%2C+Karina+M%3BBaranov%2C+Aleksandr+A%3BKozhevnikova%2C+Oksana+V%3BKalinichenko%2C+Olga+V%3BKorneeva%2C+Ekaterina+E&rft.aulast=Allik&rft.aufirst=J%C3%BCri&rft.date=2011-04-01&rft.volume=42&rft.issue=3&rft.spage=372&rft.isbn=&rft.btitle=&rft.title=Journal+of+cross-cultural+psychology&rft.issn=00220221&rft_id=info:doi/10.1177%2F0022022110362751 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9416 2153; 4551; 9429 9416 2153; 11203 11727 4546 4424; 7954; 3058 971; 2630 971; 4887 7464; 7464 DO - http://dx.doi.org/10.1177/0022022110362751 ER - TY - JOUR T1 - Adaptive behaviors in young children: a unique cultural comparison in Italy AN - 861588058; 4184751 AB - On account of a series of unique historical events, the present-day denizens of South Tyrol inhabit a cultural, political, and linguistic autonomous region that intercalates Italians and Austrian/ German Italians. The authors compared contemporary Italian and Austrian/German Italian girls' and boys' adaptive behaviors in everyday activities in this region. Using the Vineland Adaptive Behavior Scales , the authors first interviewed mothers about their children's communication, daily living, socialization, and motor skills. Main effects of local culture (and no interactions with gender) emerged: Austrian/German Italian children were rated higher than Italian children in both adaptive daily living and socialization skills. Next, the authors explored ethnic differences in childrearing. Austrian/German Italians reported fostering greater autonomy in their children than Italians, and children's autonomy was associated with their adaptive behavior. Children living in neighboring Italian and Austrian/German Italian cultural niches appear to experience subtle but consequentially different conditions of development that express themselves in terms of differing levels of adaptive behaviors. JF - Journal of cross-cultural psychology AU - Taverna, Livia AU - Bornstein, Marc H AU - Putnick, Diane L AU - Axia, Giovanna AD - Libera Università di Bolzano ; Eunice Kennedy Shriver National Institute of Child Health and Human Development ; Università degli Studi di Padova Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 445 EP - 465 VL - 42 IS - 3 SN - 0022-0221, 0022-0221 KW - Sociology KW - Comparative analysis KW - Child psychology KW - Behavioural psychology KW - Italians KW - Everyday life KW - Socialization KW - Italy KW - Behavioural sciences KW - Adaptation to change UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/861588058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cross-cultural+psychology&rft.atitle=Adaptive+behaviors+in+young+children%3A+a+unique+cultural+comparison+in+Italy&rft.au=Taverna%2C+Livia%3BBornstein%2C+Marc+H%3BPutnick%2C+Diane+L%3BAxia%2C+Giovanna&rft.aulast=Taverna&rft.aufirst=Livia&rft.date=2011-04-01&rft.volume=42&rft.issue=3&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=Journal+of+cross-cultural+psychology&rft.issn=00220221&rft_id=info:doi/10.1177%2F0022022110362748 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 2630 971; 559; 1540 1543 10404; 1542 11325; 2205 2212 10404; 6933 4546 4424; 11977; 4559; 188 396 129 DO - http://dx.doi.org/10.1177/0022022110362748 ER - TY - JOUR T1 - Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease. AN - 859759964; 21233488 AB - Parkinson's disease (PD) involves progressive loss of nigrostriatal dopamine (DA) neurons over an extended period of time. Mitochondrial damage may lead to PD, and neurotoxins affecting mitochondria are widely used to produce degeneration of the nigrostriatal circuitry. Deletion of the mitochondrial transcription factor A gene (Tfam) in C57BL6 mouse DA neurons leads to a slowly progressing parkinsonian phenotype in which motor impairment is first observed at ~12 wk of age. L-DOPA treatment improves motor dysfunction in these "MitoPark" mice, but this declines when DA neuron loss is more complete. To investigate early neurobiological events potentially contributing to PD, we compared the neurochemical and electrophysiological properties of the nigrostriatal circuit in behaviorally asymptomatic 6- to 8-wk-old MitoPark mice and age-matched control littermates. Release, but not uptake of DA, was impaired in MitoPark mouse striatal brain slices, and nigral DA neurons lacked characteristic pacemaker activity compared with control mice. Also, hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channel function was reduced in MitoPark DA neurons, although HCN messenger RNA was unchanged. This study demonstrates altered nigrostriatal function that precedes behavioral parkinsonian symptoms in this genetic PD model. A full understanding of these presymptomatic cellular properties may lead to more effective early treatments of PD. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Good, Cameron H AU - Hoffman, Alexander F AU - Hoffer, Barry J AU - Chefer, Vladimir I AU - Shippenberg, Toni S AU - Bäckman, Cristina M AU - Larsson, Nils-Göran AU - Olson, Lars AU - Gellhaar, Sandra AU - Galter, Dagmar AU - Lupica, Carl R AD - Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, U.S. Department of Health and Human Services, Baltimore, MD 21224, USA. Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 1333 EP - 1344 VL - 25 IS - 4 KW - Cyclic Nucleotide-Gated Cation Channels KW - 0 KW - DNA-Binding Proteins KW - Mitochondrial Proteins KW - Transcription Factors KW - mitochondrial transcription factor A KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Corpus Striatum KW - Dopamine -- metabolism KW - Disease Models, Animal KW - Substantia Nigra KW - Mice KW - Male KW - Female KW - Neurons -- metabolism KW - Cyclic Nucleotide-Gated Cation Channels -- physiology KW - Neurons -- physiology KW - DNA-Binding Proteins -- genetics KW - Mitochondrial Proteins -- genetics KW - Parkinson Disease -- physiopathology KW - Transcription Factors -- genetics KW - Parkinson Disease -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/859759964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Impaired+nigrostriatal+function+precedes+behavioral+deficits+in+a+genetic+mitochondrial+model+of+Parkinson%27s+disease.&rft.au=Good%2C+Cameron+H%3BHoffman%2C+Alexander+F%3BHoffer%2C+Barry+J%3BChefer%2C+Vladimir+I%3BShippenberg%2C+Toni+S%3BB%C3%A4ckman%2C+Cristina+M%3BLarsson%2C+Nils-G%C3%B6ran%3BOlson%2C+Lars%3BGellhaar%2C+Sandra%3BGalter%2C+Dagmar%3BLupica%2C+Carl+R&rft.aulast=Good&rft.aufirst=Cameron&rft.date=2011-04-01&rft.volume=25&rft.issue=4&rft.spage=1333&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=1530-6860&rft_id=info:doi/10.1096%2Ffj.10-173625 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-03 N1 - Date created - 2011-04-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuron. 2003 Sep 11;39(6):889-909 [12971891] Annu Rev Physiol. 2003;65:453-80 [12471170] Science. 1973 Nov 16;182(4113):717-20 [4752211] J Neurol Sci. 1973 Dec;20(4):415-55 [4272516] J Physiol. 1983 Jul;340:19-45 [6887047] Neuroscience. 1983 Oct;10(2):301-15 [6633863] J Neurochem. 1987 Jun;48(6):1787-93 [3106573] J Neurosci. 1987 Jun;7(6):1648-54 [3110381] Mol Chem Neuropathol. 1989 Jun;10(3):185-200 [2504173] J Neurosci. 1990 Jun;10(6):1847-54 [1693953] Trends Neurosci. 1990 Jul;13(7):290-6 [1695406] Arch Neurol. 1990 Dec;47(12):1290-8 [2123623] Brain Res. 1990 Nov 19;533(2):203-12 [2126975] Lancet. 1991 Jun 1;337(8753):1321-4 [1674304] J Physiol. 1990 Dec;431:291-318 [1712843] J Neurosci Methods. 1991 Dec;40(2-3):139-47 [1800851] Histochemistry. 1992 Aug;98(1):39-49 [1429016] J Physiol. 1993 Mar;462:753-64 [8392580] J Neurosci Methods. 1993 Jul;48(3):225-40 [8412305] J Neurosci Methods. 1993 Jul;48(3):263-76 [8105154] J Neurophysiol. 1994 Mar;71(3):1165-73 [8201410] J Neurosci Methods. 1994 Sep;54(1):75-82 [7815821] Neuroscience. 1994 Dec;63(3):757-64 [7898675] Eur J Neurosci. 1995 Mar 1;7(3):462-9 [7773443] J Neurophysiol. 1995 Dec;74(6):2366-78 [8747199] J Neurophysiol. 1996 Oct;76(4):2262-70 [8899601] J Physiol. 1996 Nov 15;497 ( Pt 1):119-30 [8951716] Brain Res. 1997 Apr 11;753(2):225-34 [9125407] Nat Genet. 1998 Mar;18(3):231-6 [9500544] Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):4029-34 [9520487] J Neurosci. 1998 Sep 1;18(17):6693-703 [9712641] J Neurosci. 1998 Sep 15;18(18):7084-98 [9736632] Nat Genet. 1999 Jan;21(1):133-7 [9916807] Brain Res Mol Brain Res. 2005 Mar 24;134(1):57-66 [15790530] Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10023-8 [16006505] Neurotoxicology. 2005 Oct;26(5):857-68 [15922452] Nat Genet. 2006 May;38(5):518-20 [16604072] Nat Genet. 2006 May;38(5):515-7 [16604074] J Neurosci Methods. 2006 Sep 15;155(2):187-93 [16466808] Genesis. 2006 Aug;44(8):383-90 [16865686] Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1325-30 [17227870] Annu Rev Neurosci. 2007;30:259-88 [17600522] FASEB J. 2008 Jan;22(1):261-75 [17690153] FEBS J. 2008 Apr;275(7):1384-91 [18279376] Mol Pharmacol. 2008 Oct;74(4):933-40 [18599602] Cell Mol Life Sci. 2009 Feb;66(3):470-94 [18953682] J Neurosci. 2009 Feb 11;29(6):1735-42 [19211880] Psychopharmacology (Berl). 2009 May;204(1):1-11 [19099297] Prog Neurobiol. 2010 Feb 9;90(2):146-56 [19925845] Genes Brain Behav. 2010 Mar 1;9(2):173-81 [20002202] Neuron. 2010 Jun 10;66(5):646-61 [20547124] Nature. 2010 Aug 26;466(7310):S8-10 [20739935] Trends Cardiovasc Med. 2002 Jul;12(5):206-12 [12161074] Neuroscience. 2002;114(2):475-92 [12204216] J Neurosci Methods. 2002 Nov 15;121(1):41-52 [12393160] J Neurosci. 2003 Nov 26;23(34):10756-64 [14645467] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1096/fj.10-173625 ER - TY - JOUR T1 - The role of TRADD in TRAIL-induced apoptosis and signaling. AN - 859758968; 21187341 AB - Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily. TRAIL is promising for anticancer therapy because it induces apoptosis in cancer cells with little or no toxicity to normal cells; hence, TRAIL-receptor agonists are currently undergoing clinical trials for cancer treatment. However, many molecular signaling mechanisms in TRAIL signaling are not completely characterized. The functions of adaptor proteins, including TNF-receptor-associated death domain protein (TRADD) and receptor-interacting protein-1 (RIP1) in TRAIL signaling have been controversial. We demonstrate that while wild-type mouse embryonic fibroblasts (MEFs) are completely resistant to TRAIL-induced apoptosis, MEFs derived from Tradd(-/-) mice are hypersensitive to TRAIL (IC(50)~0.5 nM rmTRAIL, 24 h), an effect also seen in primary keratinocytes treated with TRAIL/CHX. Restoration of TRADD in Tradd(-/-) MEFs restores TRAIL resistance, indicating that TRADD plays a survival role in TRAIL signaling. We show that TRADD is recruited to the TRAIL-receptor complex, and RIP1 recruitment is mediated by TRADD. While early activation of the MAP kinase ERK is deficient in Tradd(-/-) cells, the main mechanism for enhanced TRAIL sensitivity is likely due to increased recruitment of FADD to the receptor complex, indicating that TRADD may limit FADD binding within the receptor complex and also mediate RIP1-dependent nonapoptotic signaling events, thus reducing caspase activation and subsequent apoptosis. These novel findings have potential implications for cancer therapy using TRAIL-receptor agonists. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Cao, Xiumei AU - Pobezinskaya, Yelena L AU - Morgan, Michael J AU - Liu, Zheng-gang AD - Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 1353 EP - 1358 VL - 25 IS - 4 KW - Fadd protein, mouse KW - 0 KW - Fas-Associated Death Domain Protein KW - GTPase-Activating Proteins KW - Ralbp1 protein, mouse KW - Receptors, TNF-Related Apoptosis-Inducing Ligand KW - TNF Receptor-Associated Death Domain Protein KW - TNF-Related Apoptosis-Inducing Ligand KW - Tradd protein, mouse KW - Index Medicus KW - Animals KW - GTPase-Activating Proteins -- metabolism KW - Humans KW - Apoptosis -- physiology KW - Mice KW - Receptors, TNF-Related Apoptosis-Inducing Ligand -- agonists KW - Fas-Associated Death Domain Protein -- metabolism KW - TNF-Related Apoptosis-Inducing Ligand -- pharmacology KW - Signal Transduction -- physiology KW - TNF Receptor-Associated Death Domain Protein -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/859758968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=The+role+of+TRADD+in+TRAIL-induced+apoptosis+and+signaling.&rft.au=Cao%2C+Xiumei%3BPobezinskaya%2C+Yelena+L%3BMorgan%2C+Michael+J%3BLiu%2C+Zheng-gang&rft.aulast=Cao&rft.aufirst=Xiumei&rft.date=2011-04-01&rft.volume=25&rft.issue=4&rft.spage=1353&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=1530-6860&rft_id=info:doi/10.1096%2Ffj.10-170480 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-03 N1 - Date created - 2011-04-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2001 May 11;276(19):16484-90 [11278665] Nat Immunol. 2000 Dec;1(6):489-95 [11101870] Oncogene. 2003 Mar 27;22(12):1807-16 [12660816] EMBO Rep. 2003 Jun;4(6):623-7 [12776182] J Biol Chem. 2004 Jul 30;279(31):32780-5 [15173180] Immunity. 1997 Dec;7(6):821-30 [9430227] Immunity. 1997 Dec;7(6):831-6 [9430228] J Biol Chem. 2005 Dec 9;280(49):40599-608 [16227629] Mol Cell Biol. 2006 Nov;26(21):8136-48 [16940186] J Mol Med (Berl). 2007 Sep;85(9):923-35 [17437073] Oncogene. 2008 Jan 24;27(5):574-84 [17684487] Cell Signal. 2008 May;20(5):892-906 [18276109] Nat Protoc. 2008;3(5):799-810 [18451788] Nat Rev Cancer. 2008 Oct;8(10):782-98 [18813321] FEBS J. 2009 Jan;276(2):581-93 [19120450] Cell Res. 2009 Jun;19(6):758-67 [19434100] Nat Immunol. 2008 Sep;9(9):1047-54 [18641653] Nat Cell Biol. 2000 Apr;2(4):241-3 [10783243] Immunity. 2000 Jun;12(6):599-609 [10894160] Immunity. 2000 Jun;12(6):611-20 [10894161] J Biol Chem. 2000 Aug 18;275(33):25065-8 [10862756] Mol Cell Biol. 2000 Sep;20(18):6638-45 [10958661] J Immunol. 2002 Sep 15;169(6):2851-60 [12218097] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1096/fj.10-170480 ER - TY - JOUR T1 - The fidelity of spin trapping with DMPO in biological systems. AN - 858781470; 21246623 AB - Unlike direct ESR, spin trap methodology depends on the absolute fidelity of the spin trap reaction. Two alternative reactions of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) leading to radical adduct artifacts have been discovered and investigated: inverted spin trapping and the Forrester-Hepburn nucleophilic mechanism. These two alternate pathways to radical adducts are a combination of one-electron oxidation and nucleophilic addition, in either order. In biological systems, serious artifacts have been reported due to the Forrester-Hepburn mechanism, which is initiated by the addition of a nucleophile to DMPO. It has recently been demonstrated that (bi)sulfite (hydrated sulfur dioxide) can react with DMPO via a nonradical, nucleophilic reaction, and it has been further proposed that DMPO/(•)SO(3)(-) formation in biological systems is an artifact and not the result of spin trapping of sulfur trioxide anion radical ((•)SO(3)(-)). The one-electron oxidation of (bi)sulfite catalyzed by horseradish peroxidase (HRP)/hydrogen peroxide (H(2)O(2)) has been reinvestigated by ESR spin trapping with DMPO and oxygen uptake studies to obtain further evidence for the radical reaction mechanism. In the absence of DMPO, the initial rate of (bi)sulfite-dependent oxygen and H(2)O(2) consumption was determined to be half of the initial rate of DMPO/(•)SO(3)(-) radical adduct formation as determined by ESR, demonstrating that, under our experimental conditions, DMPO exclusively forms the radical adduct by trapping the (•)SO(3)(-). Copyright © 2011 John Wiley & Sons, Ltd. JF - Magnetic resonance in chemistry : MRC AU - Ranguelova, Kalina AU - Mason, Ronald P AD - Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 152 EP - 158 VL - 49 IS - 4 KW - Cyclic N-Oxides KW - 0 KW - Free Radicals KW - Sulfur Oxides KW - 5,5-dimethyl-1-pyrroline-1-oxide KW - 7170JZ1QF3 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Horseradish Peroxidase KW - EC 1.11.1.- KW - sulfur trioxide KW - HH2O7V4LYD KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Sulfur Oxides -- metabolism KW - Oxygen -- metabolism KW - Hydrogen Peroxide -- metabolism KW - Electron Spin Resonance Spectroscopy KW - Oxygen -- chemistry KW - Free Radicals -- chemistry KW - Horseradish Peroxidase -- chemistry KW - Sulfur Oxides -- chemistry KW - Free Radicals -- metabolism KW - Hydrogen Peroxide -- chemistry KW - Horseradish Peroxidase -- metabolism KW - Biocatalysis KW - Spin Trapping KW - Cyclic N-Oxides -- metabolism KW - Cyclic N-Oxides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/858781470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+resonance+in+chemistry+%3A+MRC&rft.atitle=The+fidelity+of+spin+trapping+with+DMPO+in+biological+systems.&rft.au=Ranguelova%2C+Kalina%3BMason%2C+Ronald+P&rft.aulast=Ranguelova&rft.aufirst=Kalina&rft.date=2011-04-01&rft.volume=49&rft.issue=4&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Magnetic+resonance+in+chemistry+%3A+MRC&rft.issn=1097-458X&rft_id=info:doi/10.1002%2Fmrc.2709 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-01 N1 - Date created - 2011-03-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1982 May 10;257(9):5050-5 [6279657] Food Cosmet Toxicol. 1981 Oct;19(5):667-82 [6171492] Environ Health Perspect. 1985 Dec;64:209-17 [3830699] Proc Natl Acad Sci U S A. 1986 Oct;83(19):7499-502 [3463979] Biochem Biophys Res Commun. 1986 Dec 15;141(2):622-8 [3026386] Radiat Environ Biophys. 1987;26(4):289-94 [3685252] Free Radic Biol Med. 1987;3(4):259-303 [2826304] Arch Biochem Biophys. 1988 Dec;267(2):681-9 [2850769] Chem Biol Interact. 1989;70(1-2):167-72 [2544305] Methods Enzymol. 1990;186:127-33 [2172700] Biochem Biophys Res Commun. 1990 Nov 15;172(3):1073-80 [2173913] Arch Biochem Biophys. 1993 Jun;303(2):185-94 [8390216] Biochem Biophys Res Commun. 1994 Nov 30;205(1):141-7 [7999014] J Inorg Biochem. 1994 Nov 15;56(3):155-65 [7798899] Bioinformatics. 1998;14(10):869-83 [9927716] Free Radic Biol Med. 2009 Jul 15;47(2):128-34 [19362142] Arch Biochem Biophys. 1992 Aug 1;296(2):640-4 [1321591] Free Radic Biol Med. 2003 Jan 15;34(2):196-206 [12521601] Free Radic Biol Med. 2004 May 1;36(9):1072-86 [15082061] J Biol Chem. 1968 Nov 10;243(21):5753-60 [4972775] Anal Biochem. 1971 Nov;44(1):276-87 [4943714] Biochemistry. 1976 Jul 13;15(14):3059-63 [8081] Mol Pharmacol. 1982 Nov;22(3):732-7 [6296662] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/mrc.2709 ER - TY - JOUR T1 - Identification of human parainfluenza virus type 2 (HPIV-2) V protein amino acid residues that reduce binding of V to MDA5 and attenuate HPIV-2 replication in nonhuman primates. AN - 858285068; 21289116 AB - Human parainfluenza virus type 2 (HPIV-2), an important pediatric respiratory pathogen, encodes a V protein that inhibits type I interferon (IFN) induction and signaling. Using reverse genetics, we attempted the recovery of a panel of V mutant viruses that individually contained one of six cysteine-to-serine (residues 193, 197, 209, 211, 214, and 218) substitutions, one of two paired charge-to-alanine (R175A/R176A and R205A/K206A) substitutions, or a histidine-to-phenylalanine (H174F) substitution. This mutagenesis was performed using a cDNA-derived HPIV-2 virus that expressed the V and P coding sequences from separate mRNAs. Of the cysteine substitutions, only C193S, C214S, and C218S yielded viable virus, and only the C214S mutant replicated well enough for further analysis. The H174F, R175A/R176A, and R205A/K206A mutants were viable and replicated well. The H174F and R205A/K206A mutants did not differ from the wild-type (WT) V in their ability to physically interact with MDA5, a cytoplasmic sensor of nonself RNA that induces type I IFN. Like WT HPIV-2, these mutants inhibited IFN-β induction and replicated efficiently in African green monkeys (AGMs). In contrast, the C214S and R175A/R176A mutants did not bind MDA5 efficiently, did not inhibit interferon regulatory factor 3 (IRF3) dimerization or IFN-β induction, and were attenuated in AGMs. These findings indicate that V binding to MDA5 is important for HPIV-2 virulence in nonhuman primates and that some V protein residues involved in MDA5 binding are not essential for efficient HPIV-2 growth in vitro. Using a transient expression system, 20 additional mutant V proteins were screened for MDA5 binding, and the region spanning residues 175 to 180 was found to be essential for this activity. JF - Journal of virology AU - Schaap-Nutt, Anne AU - Higgins, Caraline AU - Amaro-Carambot, Emerito AU - Nolan, Sheila M AU - D'Angelo, Christopher AU - Murphy, Brian R AU - Collins, Peter L AU - Schmidt, Alexander C AD - LID, NIAID, NIH, 50 South Drive, Room 6511, MSC 8007, Bethesda, MD 20892, USA. Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 4007 EP - 4019 VL - 85 IS - 8 KW - Amino Acids KW - 0 KW - Mutant Proteins KW - V protein, human parainfluenza virus type 1 KW - Viral Proteins KW - Virulence Factors KW - DEAD-box RNA Helicases KW - EC 3.6.4.13 KW - Index Medicus KW - Mutant Proteins -- genetics KW - Mutagenesis, Site-Directed KW - Animals KW - Microbial Viability KW - Amino Acid Substitution -- genetics KW - Mutant Proteins -- metabolism KW - Humans KW - Cercopithecus aethiops KW - Amino Acids -- genetics KW - Macaca mulatta KW - Amino Acids -- metabolism KW - Protein Binding KW - Cell Line KW - Virus Replication KW - Viral Proteins -- genetics KW - Parainfluenza Virus 2, Human -- genetics KW - DEAD-box RNA Helicases -- metabolism KW - Virulence Factors -- metabolism KW - Viral Proteins -- metabolism KW - Virulence Factors -- genetics KW - Parainfluenza Virus 2, Human -- pathogenicity KW - Host-Pathogen Interactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/858285068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Identification+of+human+parainfluenza+virus+type+2+%28HPIV-2%29+V+protein+amino+acid+residues+that+reduce+binding+of+V+to+MDA5+and+attenuate+HPIV-2+replication+in+nonhuman+primates.&rft.au=Schaap-Nutt%2C+Anne%3BHiggins%2C+Caraline%3BAmaro-Carambot%2C+Emerito%3BNolan%2C+Sheila+M%3BD%27Angelo%2C+Christopher%3BMurphy%2C+Brian+R%3BCollins%2C+Peter+L%3BSchmidt%2C+Alexander+C&rft.aulast=Schaap-Nutt&rft.aufirst=Anne&rft.date=2011-04-01&rft.volume=85&rft.issue=8&rft.spage=4007&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.02542-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-18 N1 - Date created - 2011-03-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2006 May 30;103(22):8459-64 [16714379] Virology. 2002 Nov 10;303(1):33-46 [12482656] Cancer Cell. 2003 Oct;4(4):263-75 [14585354] J Virol. 2004 Feb;78(4):2017-28 [14747566] J Virol. 2004 Feb;78(4):2029-36 [14747567] Virology. 2004 Jul 20;325(1):137-48 [15231393] J Gen Virol. 1979 Apr;43(1):247-52 [113494] Mol Cell Biol. 1986 Jun;6(6):2279-83 [3785197] Bull World Health Organ. 1988;66(3):391-7 [2844427] Virology. 1989 Jul;171(1):38-48 [2545038] J Virol. 1990 Aug;64(8):3833-43 [1695256] Virology. 1991 Sep;184(1):108-16 [1651586] Eur J Biochem. 1992 Jun 15;206(3):901-10 [1318841] Virus Res. 1992 Mar;22(3):173-84 [1320790] J Virol. 1999 Jan;73(1):251-9 [9847328] J Virol. 1999 Apr;73(4):3438-42 [10074199] JAMA. 1963 Feb 2;183:324-30 [13962308] Am J Public Health Nations Health. 1962 Jun;52:907-17 [14038204] Virology. 2007 May 25;362(1):85-98 [17250865] Microbes Infect. 2007 Jul;9(8):954-62 [17548221] Vaccine. 2007 Aug 21;25(34):6409-22 [17658669] J Virol. 2007 Nov;81(22):12238-48 [17855551] J Biol Chem. 2008 May 23;283(21):14269-76 [18362155] J Virol. 2008 Jul;82(13):6130-8 [18417591] J Exp Med. 2008 Jul 7;205(7):1523-7 [18591413] PLoS Pathog. 2008 Jul;4(7):e1000108 [18636103] Nature. 2008 Jul 24;454(7203):523-7 [18548002] J Virol. 2008 Nov;82(21):10580-90 [18768976] J Virol. 2008 Dec;82(24):12365-73 [18922877] J Virol. 2009 Feb;83(3):1465-73 [19019954] Biofactors. 2009 Jan-Feb;35(1):14-20 [19319841] Transplantation. 2009 May 27;87(10):1530-7 [19461490] J Virol. 2009 Jul;83(14):7252-60 [19403670] J Virol. 2010 Jan;84(1):372-9 [19846522] PLoS Pathog. 2010 Jan;6(1):e1000734 [20107606] Virology. 2010 Feb 20;397(2):285-98 [19969320] Virology. 2010 Oct 10;406(1):65-79 [20667570] J Virol. 2010 Nov;84(21):11152-63 [20719949] J Virol. 2004 Dec;78(23):13037-45 [15542655] Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17264-9 [15563593] Eur J Biochem. 2004 Dec;271(23-24):4621-8 [15606749] Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2986-91 [15710892] J Virol. 2005 Jul;79(13):8591-601 [15956600] J Immunol. 2005 Sep 1;175(5):2851-8 [16116171] Vaccine. 2005 Sep 15;23(39):4765-74 [15964103] Cell. 2006 Jan 13;124(1):105-17 [16413485] J Infect Dis. 2006 Feb 15;193(4):573-81 [16425137] Virology. 2006 Aug 15;352(1):61-73 [16750233] Microbes Infect. 2006 Jul;8(8):2138-44 [16782388] Virology. 2007 Mar 1;359(1):190-200 [17049367] J Virol. 1999 Dec;73(12):9928-33 [10559305] Virology. 2000 Apr 10;269(2):383-90 [10753717] Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4309-14 [10725408] J Virol. 2000 Oct;74(19):9152-66 [10982362] J Virol. 2000 Oct;74(19):9317-21 [10982380] J Gen Virol. 2000 Oct;81(Pt 10):2341-64 [10993923] Virology. 2001 May 25;284(1):99-112 [11352671] Virology. 1995 Apr 1;208(1):121-31 [11831692] J Virol. 2002 Mar;76(5):2159-67 [11836393] Virus Genes. 2002;24(1):77-92 [11928991] Virology. 2002 Aug 15;300(1):92-9 [12202209] J Virol. 2002 Oct;76(20):10109-21 [12239285] J Virol. 2003 Jan;77(1):270-9 [12477832] Virology. 2002 Nov 10;303(1):15-32 [12482655] Nature. 2006 May 4;441(7089):101-5 [16625202] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.02542-10 ER - TY - JOUR T1 - Human papillomavirus (HPV) genotypes and HPV16 variants and risk of adenocarcinoma and squamous cell carcinoma of the cervix. AN - 858282023; 21211829 AB - Human papillomavirus (HPV) genotypes have been extensively studied in uterine cervix squamous cell carcinoma and HPV16 variants have been found to be associated with increased cancer risk, but few reports have been published on genotype distribution and HPV16 variant prevalence in adenocarcinoma tumors. The objective of this study was to analyze viral genotypes and HPV16 intratypic variants in cervical adenocarcinoma and squamous cell carcinoma of Italian women. A total of 39 invasive adenocarcinoma and 132 squamous cell carcinoma were reviewed and classified according to the modified WHO classification. HPV sequences were detected by nested PCR, using the broad spectrum consensus-primer pairs MY09/MY11 and the GP5+/GP6+ system, and genotyped by nucleotide sequence analysis. The HPV16-positive cases were amplified with E6-specific oligonucleotides and amplimers subjected to direct nucleotide sequence for variant identification. The prevalence rate of any HPV infection was 72% in adenocarcinoma, and 85% in cervical squamous cell carcinoma. Among the 140 HPV-positive cancer cases, a total of nine mucosal HPV genotypes (HPV16, 18, 31, 33, 35, 39, 45, 58, 82) epidemiologically classified as carcinogenic or probably carcinogenic viruses were identified. The HPV type 16 was the most common viral type representing 64% and 73% of all infections in adenocarcinoma and squamous cell carcinoma, respectively. The E6 nucleotide sequence analysis of HPV16 isolates allowed the identification of Asian American (AA) variants in 33% of adenocarcinoma and in 20% of squamous cell carcinoma suggesting their stronger association with cancer of glandular origin. These results suggest that HPV16 has a high prevalence in both invasive adenocarcinoma and squamous cell carcinoma from Italian patients. Moreover this study confirms previous observations, summarized in a systematic review of the literature, on the increased cancer risk of HPV16 AA class in adenoglandular cancer, possibly related to their more oncogenic behavior compared to HPV16 European variants. Copyright © 2010 Elsevier Inc. All rights reserved. JF - Gynecologic oncology AU - Tornesello, M L AU - Losito, S AU - Benincasa, G AU - Fulciniti, F AU - Botti, G AU - Greggi, S AU - Buonaguro, L AU - Buonaguro, F M AD - Molecular Biology and Viral Oncology Unit, and AIDS Reference Centre, National Cancer Institute, Fond. Pascale, Naples, Italy. Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 32 EP - 42 VL - 121 IS - 1 KW - Index Medicus KW - Genotype KW - Polymerase Chain Reaction KW - Humans KW - Italy -- epidemiology KW - Female KW - Papillomavirus Infections -- epidemiology KW - Adenocarcinoma -- epidemiology KW - Carcinoma, Squamous Cell -- epidemiology KW - Uterine Cervical Neoplasms -- epidemiology KW - Human papillomavirus 16 -- isolation & purification KW - Papillomavirus Infections -- complications KW - Papillomavirus Infections -- virology KW - Human papillomavirus 16 -- genetics KW - Adenocarcinoma -- virology KW - Carcinoma, Squamous Cell -- virology KW - Uterine Cervical Neoplasms -- virology KW - Human papillomavirus 16 -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/858282023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gynecologic+oncology&rft.atitle=Human+papillomavirus+%28HPV%29+genotypes+and+HPV16+variants+and+risk+of+adenocarcinoma+and+squamous+cell+carcinoma+of+the+cervix.&rft.au=Tornesello%2C+M+L%3BLosito%2C+S%3BBenincasa%2C+G%3BFulciniti%2C+F%3BBotti%2C+G%3BGreggi%2C+S%3BBuonaguro%2C+L%3BBuonaguro%2C+F+M&rft.aulast=Tornesello&rft.aufirst=M&rft.date=2011-04-01&rft.volume=121&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Gynecologic+oncology&rft.issn=1095-6859&rft_id=info:doi/10.1016%2Fj.ygyno.2010.12.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-16 N1 - Date created - 2011-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ygyno.2010.12.005 ER - TY - JOUR T1 - Power play: scoring our goals for liver cancer with better GWAS study design. AN - 857812812; 21167853 JF - Journal of hepatology AU - Budhu, Anuradha AU - Wang, Xin Wei AD - Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 823 EP - 824 VL - 54 IS - 4 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/857812812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hepatology&rft.atitle=Power+play%3A+scoring+our+goals+for+liver+cancer+with+better+GWAS+study+design.&rft.au=Budhu%2C+Anuradha%3BWang%2C+Xin+Wei&rft.aulast=Budhu&rft.aufirst=Anuradha&rft.date=2011-04-01&rft.volume=54&rft.issue=4&rft.spage=823&rft.isbn=&rft.btitle=&rft.title=Journal+of+hepatology&rft.issn=1600-0641&rft_id=info:doi/10.1016%2Fj.jhep.2010.10.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-15 N1 - Date created - 2011-03-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Nat Genet. 2010 Sep;42(9):755-8 [20676096] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jhep.2010.10.035 ER - TY - JOUR T1 - Rotavirus VP2 core shell regions critical for viral polymerase activation. AN - 857484196; 21248043 AB - The innermost VP2 core shell of the triple-layered, icosahedral rotavirus particle surrounds the viral genome and RNA processing enzymes, including the RNA-dependent RNA polymerase (VP1). In addition to anchoring VP1 within the core, VP2 is also an essential cofactor that triggers the polymerase to initiate double-stranded RNA (dsRNA) synthesis using packaged plus-strand RNA templates. The VP2 requirement effectively couples packaging with genome replication and ensures that VP1 makes dsRNA only within an assembling previrion particle. However, the mechanism by which the rotavirus core shell protein activates the viral polymerase remains very poorly understood. In the current study, we sought to elucidate VP2 regions critical for VP1-mediated in vitro dsRNA synthesis. By comparing the functions of proteins from several different rotaviruses, we found that polymerase activation by the core shell protein is specific. Through truncation and chimera mutagenesis, we demonstrate that the VP2 amino terminus, which forms a decameric, internal hub underneath each 5-fold axis, plays an important but nonspecific role in VP1 activation. Our results indicate that the VP2 residues correlating with polymerase activation specificity are located on the inner face of the core shell, distinct from the amino terminus. Based on these findings, we predict that several regions of VP2 engage the polymerase during the concerted processes of rotavirus core assembly and genome replication. JF - Journal of virology AU - McDonald, Sarah M AU - Patton, John T AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Room 6311, Bethesda, MD 20892-8026, USA. mcdonaldsa@niaid.nih.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 3095 EP - 3105 VL - 85 IS - 7 KW - Capsid Proteins KW - 0 KW - RNA, Double-Stranded KW - RNA, Viral KW - VP1 protein, Rotavirus KW - VP2 protein, Rotavirus KW - Viral Core Proteins KW - Index Medicus KW - Virus Assembly KW - Animals KW - Spodoptera KW - Models, Molecular KW - Amino Acid Sequence KW - Sequence Analysis, DNA KW - RNA, Double-Stranded -- metabolism KW - Sequence Alignment KW - Recombination, Genetic KW - Molecular Sequence Data KW - RNA, Viral -- genetics KW - RNA, Viral -- metabolism KW - Cell Line KW - Sequence Deletion KW - Virus Replication KW - Capsid Proteins -- metabolism KW - Protein Interaction Mapping KW - Viral Core Proteins -- genetics KW - Rotavirus -- genetics KW - Viral Core Proteins -- metabolism KW - Capsid Proteins -- genetics KW - Rotavirus -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/857484196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Rotavirus+VP2+core+shell+regions+critical+for+viral+polymerase+activation.&rft.au=McDonald%2C+Sarah+M%3BPatton%2C+John+T&rft.aulast=McDonald&rft.aufirst=Sarah&rft.date=2011-04-01&rft.volume=85&rft.issue=7&rft.spage=3095&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.02360-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-13 N1 - Date created - 2011-03-16 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - HQ540508; GENBANK; HQ540507 N1 - SuppNotes - Cited By: Cell. 2002 Nov 27;111(5):733-45 [12464184] Virology. 2010 Sep 15;405(1):201-13 [20580391] J Biol Chem. 2003 Aug 29;278(35):32673-82 [12788926] Virus Res. 2004 Apr;101(1):3-13 [15010213] Virus Res. 2004 Apr;101(1):67-81 [15010218] J Comput Chem. 2004 Oct;25(13):1605-12 [15264254] Virology. 1989 Oct;172(2):616-27 [2552662] J Gen Virol. 1990 May;71 ( Pt 5):1087-94 [2161046] J Virol. 1991 Jun;65(6):2946-52 [1851866] Virology. 1994 May 15;201(1):55-65 [8178489] J Gen Virol. 1994 Dec;75 ( Pt 12):3423-30 [7996135] J Virol. 1996 Nov;70(11):7940-7 [8892917] J Virol. 1997 Oct;71(10):7353-60 [9311813] J Virol. 1997 Dec;71(12):9618-26 [9371626] J Virol. 1998 Jan;72(1):201-8 [9420216] Curr Top Microbiol Immunol. 2006;309:189-219 [16913048] J Virol. 2007 Mar;81(5):2128-37 [17182692] Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1867-72 [18238898] Structure. 2008 Nov 12;16(11):1678-88 [19000820] J Virol. 2009 Feb;83(4):1754-66 [19036817] J Virol. 2009 Jun;83(12):6135-48 [19357162] Curr Opin Struct Biol. 2009 Dec;19(6):775-82 [19914820] J Mol Biol. 2010 Mar 26;397(2):587-99 [20122940] J Biol Chem. 2010 Jun 11;285(24):18123-8 [20351108] J Virol. 2003 Feb;77(3):1757-63 [12525609] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.02360-10 ER - TY - JOUR T1 - A pilot study evaluating the safety and CD34+ cell mobilizing activity of escalating doses of plerixafor in healthy volunteers. AN - 856789349; 21352197 AB - This study evaluated the safety and CD34+ cell mobilizing activity of escalating doses of plerixafor in healthy volunteers. Three cohorts of six subjects received two different doses of plerixafor separated by at least 2 weeks to allow for adequate pharmacodynamic wash-out. The following dosing cohorts were evaluated: 0·24 and 0·32 mg/kg (Cohort 1); 0·32 and 0·40 mg/kg (Cohort 2); and 0·40 and 0·48 mg/kg (Cohort 3). Circulating CD34+ cells were measured 0, 2, 4, 6, 8, 10, 12, 14, 18 and 24 h after each dose. Blood colony-forming units were measured at baseline and 6 h after each dose. Common adverse events were diarrhoea, injection site erythema, perioral numbness, sinus tachycardia, headache, nausea, abdominal distention and injection site pain. No dose limiting toxicities occurred. When higher doses of plerixafor were administered, there was a trend towards higher peak CD34+ counts and CD34+ area under the curves, although these differences did not achieve statistical significance, perhaps due to intra-subject variability. Together, these data show that the higher doses of plerixafor evaluated in this study are reasonably safe and suggest that a larger study should be performed to definitively answer whether increased numbers of CD34+ cell are mobilized with higher doses of plerixafor. © 2011 Blackwell Publishing Ltd. JF - British journal of haematology AU - Lemery, Steven J AU - Hsieh, Matthew M AU - Smith, Aleah AU - Rao, Sheila AU - Khuu, Hanh M AU - Theresa, Donohue AU - Viano, Jennifer M AU - Cook, Lisa AU - Goodwin, Rose AU - Boss, Carol AU - Calandra, Gary AU - Geller, Nancy AU - Tisdale, John AU - Childs, Richard AD - NHLBI, NIH, Bethesda, MD, USA. Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 66 EP - 75 VL - 153 IS - 1 KW - Antigens, CD34 KW - 0 KW - Heterocyclic Compounds KW - Receptors, CXCR4 KW - JM 3100 KW - 155148-31-5 KW - Index Medicus KW - Young Adult KW - Dose-Response Relationship, Drug KW - Humans KW - Cohort Studies KW - Adult KW - Receptors, CXCR4 -- antagonists & inhibitors KW - Pilot Projects KW - Middle Aged KW - Colony-Forming Units Assay KW - Adolescent KW - Male KW - Female KW - Heterocyclic Compounds -- administration & dosage KW - Hematopoietic Stem Cell Mobilization -- methods KW - Heterocyclic Compounds -- blood KW - Heterocyclic Compounds -- adverse effects KW - Antigens, CD34 -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856789349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+haematology&rft.atitle=A+pilot+study+evaluating+the+safety+and+CD34%2B+cell+mobilizing+activity+of+escalating+doses+of+plerixafor+in+healthy+volunteers.&rft.au=Lemery%2C+Steven+J%3BHsieh%2C+Matthew+M%3BSmith%2C+Aleah%3BRao%2C+Sheila%3BKhuu%2C+Hanh+M%3BTheresa%2C+Donohue%3BViano%2C+Jennifer+M%3BCook%2C+Lisa%3BGoodwin%2C+Rose%3BBoss%2C+Carol%3BCalandra%2C+Gary%3BGeller%2C+Nancy%3BTisdale%2C+John%3BChilds%2C+Richard&rft.aulast=Lemery&rft.aufirst=Steven&rft.date=2011-04-01&rft.volume=153&rft.issue=1&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=British+journal+of+haematology&rft.issn=1365-2141&rft_id=info:doi/10.1111%2Fj.1365-2141.2010.08547.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-06 N1 - Date created - 2011-03-11 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Transfusion. 2003 Apr;43(4):495-501 [12662283] Oncology. 2010;78(3-4):282-8 [20530974] J Clin Oncol. 2004 Mar 15;22(6):1095-102 [15020611] Bone Marrow Transplant. 2004 Jun;33(11):1083-7 [15077126] J Hematother. 1996 Jun;5(3):213-26 [8817388] J Exp Med. 1997 Jan 6;185(1):111-20 [8996247] Br J Haematol. 1999 Jun;105(3):775-9 [10354146] Clin Pharmacol Ther. 2005 May;77(5):427-36 [15900288] Blood. 2005 Sep 1;106(5):1867-74 [15890685] Blood. 2006 May 1;107(9):3772-8 [16439684] Biol Blood Marrow Transplant. 2007 Mar;13(3):339-44 [17317587] Blood. 2008 Aug 15;112(4):990-8 [18426988] Blood. 2008 Sep 1;112(5):2092-100 [18523146] Biol Blood Marrow Transplant. 2009 Jan;15(1):39-46 [19135941] Blood. 2009 Sep 17;114(12):2530-41 [19602709] Blood. 2009 Sep 24;114(13):2606-16 [19608747] Bone Marrow Transplant. 2009 Nov;44(9):613-5 [19308036] Blood. 2003 Oct 15;102(8):2728-30 [12855591] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/j.1365-2141.2010.08547.x ER - TY - JOUR T1 - Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10. AN - 856775245; 21294722 AB - Neuronal or photoreceptor deficit observed in uveitis and multiple sclerosis derives in part from inability to control inflammatory responses in neuroretina or brain. Recently, IL-27 was found to play a role in suppressing experimental autoimmune uveitis and experimental autoimmune encephalomyelitis, two animal models that share essential pathological features of human uveitis and multiple sclerosis, respectively. However, the mechanism by which interleukin-27 (IL-27) inhibits central nervous system (CNS) inflammation is not clear. In this study we have investigated mechanisms that mitigate or curtail intraocular inflammation (uveitis) and examined whether inhibitory effects of IL-27 are mediated locally by neuroretinal cells or by regulatory T cells. We show here that microglia cells in the neuroretina constitutively secrete IL-27 and its expression is up-regulated during uveitis. We further show that photoreceptors constitutively express IL-27 receptor and respond to IL-27 signalling by producing anti-inflammatory molecules, IL-10 and suppressor of cytokine signalling 1 (SOCS1) through signal transducer and activator of transcription 1 (STAT1) -dependent mechanisms. Moreover, STAT1-deficient mice produced reduced amounts of IL-27, IL-10 and SOCS1 and developed more severe uveitis. Surprisingly, IL-10-producing regulatory T cells had marginal roles in suppressing uveitis. These results suggest that suppression of intraocular inflammation might be mediated through endogenous production of IL-27 and IL-10 by retinal cells, whereas SOCS proteins induced by IL-27 during uveitis may function to protect the neuroretinal cells from the toxic effects of pro-inflammatory cytokines. Targeted delivery of IL-27 into immune privileged tissues of the CNS may therefore be beneficial in the treatment of CNS inflammatory diseases, such as uveitis and multiple sclerosis. © 2011 The Authors. Immunology © 2011 Blackwell Publishing Ltd. JF - Immunology AU - Lee, Yun Sang AU - Amadi-Obi, Ahjoku AU - Yu, Cheng-Rong AU - Egwuagu, Charles E AD - Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892-1857, USA. Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 492 EP - 502 VL - 132 IS - 4 KW - Interleukin-17 KW - 0 KW - Receptors, Interleukin KW - STAT1 Transcription Factor KW - Socs1 protein, mouse KW - Suppressor of Cytokine Signaling 1 Protein KW - Suppressor of Cytokine Signaling Proteins KW - Interleukin-10 KW - 130068-27-8 KW - Index Medicus KW - Microscopy, Confocal KW - Central Nervous System -- metabolism KW - Animals KW - Humans KW - Receptors, Interleukin -- genetics KW - Aged KW - T-Lymphocytes, Regulatory -- metabolism KW - Mice, Knockout KW - STAT1 Transcription Factor -- immunology KW - Suppressor of Cytokine Signaling Proteins -- immunology KW - Central Nervous System -- immunology KW - STAT1 Transcription Factor -- metabolism KW - Receptors, Interleukin -- immunology KW - Microglia -- metabolism KW - Receptors, Interleukin -- metabolism KW - STAT1 Transcription Factor -- genetics KW - Mice KW - Suppressor of Cytokine Signaling Proteins -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - Suppressor of Cytokine Signaling Proteins -- metabolism KW - Blotting, Western KW - Cells, Cultured KW - Microglia -- immunology KW - Mice, Inbred C57BL KW - Central Nervous System -- pathology KW - Female KW - Cell Line KW - T-Lymphocytes, Regulatory -- immunology KW - Retina -- metabolism KW - Interleukin-17 -- metabolism KW - Interleukin-10 -- metabolism KW - Uveitis -- genetics KW - Interleukin-10 -- immunology KW - Interleukin-17 -- immunology KW - Uveitis -- metabolism KW - Uveitis -- immunology KW - Interleukin-17 -- genetics KW - Interleukin-10 -- genetics KW - Retina -- pathology KW - Retina -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856775245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunology&rft.atitle=Retinal+cells+suppress+intraocular+inflammation+%28uveitis%29+through+production+of+interleukin-27+and+interleukin-10.&rft.au=Lee%2C+Yun+Sang%3BAmadi-Obi%2C+Ahjoku%3BYu%2C+Cheng-Rong%3BEgwuagu%2C+Charles+E&rft.aulast=Lee&rft.aufirst=Yun&rft.date=2011-04-01&rft.volume=132&rft.issue=4&rft.spage=492&rft.isbn=&rft.btitle=&rft.title=Immunology&rft.issn=1365-2567&rft_id=info:doi/10.1111%2Fj.1365-2567.2010.03379.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-06 N1 - Date created - 2011-03-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Ophthalmol. 2000 Oct;130(4):492-513 [11024423] Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):114-9 [9419338] Eur Cytokine Netw. 2002 Jan-Mar;13(1):47-53 [11956020] J Immunol. 2002 Jun 15;168(12):6404-11 [12055259] Immunity. 2002 Jun;16(6):779-90 [12121660] Int Rev Immunol. 2002 Mar-Jun;21(2-3):273-89 [12424847] J Exp Med. 1999 Jan 18;189(2):219-30 [9892605] Cell Mol Life Sci. 1999 Sep;55(12):1568-77 [10526574] Brain Res. 2005 Apr 8;1040(1-2):202-7 [15804443] J Neurol Sci. 2005 May 15;232(1-2):3-9 [15850576] Nat Rev Immunol. 2005 Jul;5(7):521-31 [15999093] J Neuroimmunol. 2005 Nov;168(1-2):118-27 [16154209] J Immunol. 2006 Jan 1;176(1):237-47 [16365415] J Immunol. 2006 Mar 1;176(5):2773-80 [16493033] Nat Immunol. 2006 Sep;7(9):929-36 [16906167] Adv Exp Med Biol. 2006;572:275-81 [17249584] Nat Med. 2007 Jun;13(6):711-8 [17496900] Nat Immunol. 2007 Dec;8(12):1380-9 [17994022] Nat Immunol. 2007 Dec;8(12):1372-9 [17994023] Nat Immunol. 2007 Dec;8(12):1363-71 [17994025] J Exp Med. 2003 Feb 17;197(4):425-36 [12591901] J Autoimmun. 2003 Nov;21(3):283-93 [14599854] J Exp Med. 2004 Jan 5;199(1):25-34 [14699080] J Immunol. 2004 Feb 15;172(4):2225-31 [14764690] J Immunol. 2004 Feb 15;172(4):2307-15 [14764699] J Exp Med. 2004 Jul 5;200(1):79-87 [15238607] J Cell Biol. 1983 Jul;97(1):253-7 [6345555] Ophthalmology. 1985 Apr;92(4):467-71 [4000641] Int Ophthalmol. 1990 Oct;14(5-6):303-8 [2249907] Invest Ophthalmol Vis Sci. 1991 Dec;32(13):3131-41 [1748544] J Immunol. 1994 Jan 15;152(2):890-9 [8283058] J Immunol. 2008 May 1;180(9):6070-6 [18424728] Diabetes. 2008 Jun;57(6):1651-8 [18356406] J Immunol. 2009 May 1;182(9):5748-56 [19380822] Exp Eye Res. 2009 Nov;89(5):757-66 [19596318] J Immunol. 2009 Dec 15;183(12):7692-702 [19933857] J Immunol. 2002 Apr 1;168(7):3181-7 [11907070] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2567.2010.03379.x ER - TY - JOUR T1 - Need, feasibility and convenience of dosimetric treatment planning in liver selective internal radiation therapy with (90)Y microspheres: the experience of the National Tumor Institute of Milan. AN - 856409379; 21386789 AB - In most centres, the choice of the optimal activity to be administered in selective intra-arterial radioembolization with microspheres is nowadays based on empirical models which do not take into account the evaluation of tumour and non tumour individual absorbed dose, despite plenty of published data which showed that local efficacy is correlated to tumour absorbed dose, and that the mean absorbed dose is a toxicity risk factor. A pitfall of the crudest, empirical tumour involvement method are 20 deaths in a single centre which adopted it to administer the whole liver, or the need of systematic 25% subjective reduction of activity prescribed with body surface area method. In order to develop a possibly safer and more effective strategy based on real individual dosimetry, we examine first external beam liver radiation therapy results. The half century experience has something to be borrowed: the volume effect, according to which the smaller the fraction of the irradiated liver volume, the higher the tolerated dose. Different tolerance for different underlying disease or previous non radiation treatment is to be expected. Radiobiological models experience also has to be inherited, but not their dose reference values. Then we report the published dosimetric experience about (90)Y microsphere radioembolization of primary and metastatic liver tumours. In addition we also present original data from our growing preliminary experience of more refined (99m)Tc MAA SPECT based calculations in hepatocarcinoma patients. This overcame the mean dose approach in favour of the evaluation of dose distribution at voxel level. An insight into dosimetry issues at microscopic level (lobule level) is also provided, from which the different radiobiological behaviour between resin and glass spheres can be understood. For tumour treatment, an attenuation corrected (99m)Tc- SPECT based treatment planning strategy can be proposed, although quantitative efficacy thresholds should be differentiated according to the kind of pathology and previous treatment. For non tumour liver parenchyma, data in favour of a relationship between absorbed dose and dangerous effects are encouraging. Unfortunately in hepato-cellular carcinoma, some confounding factors may hamper the adequate estimation of the risk of toxicity. First there is a lack of consensus about the exact definition of toxicity after (90)Y microsphere radioembolization. Second, for HCC patients, progression of both cancer and cirrhosis can simulate a radioinduced toxicity, making the analysis more complex. JF - The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... AU - Chiesa, C AU - Maccauro, M AU - Romito, R AU - Spreafico, C AU - Pellizzari, S AU - Negri, A AU - Sposito, C AU - Morosi, C AU - Civelli, E AU - Lanocita, R AU - Camerini, T AU - Bampo, C AU - Bhoori, S AU - Seregni, E AU - Marchianò, A AU - Mazzaferro, V AU - Bombardieri, E AD - Department of Nuclear Medicine, National Cancer Institute, IRCCS Foundation, Milan, Italy. carlo.chiesa@istitutotumori.mi.it Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 168 EP - 197 VL - 55 IS - 2 SN - 1824-4785, 1824-4785 KW - Yttrium Radioisotopes KW - 0 KW - Index Medicus KW - Embolization, Therapeutic -- methods KW - Liver -- injuries KW - Humans KW - Carcinoma, Hepatocellular -- radiotherapy KW - Radiation Pneumonitis -- etiology KW - Academies and Institutes KW - Dose-Response Relationship, Radiation KW - Models, Biological KW - Radiobiology KW - Microspheres KW - Liver -- radiation effects KW - Italy KW - Liver Neoplasms -- radiotherapy KW - Yttrium Radioisotopes -- therapeutic use KW - Yttrium Radioisotopes -- administration & dosage KW - Radiotherapy Planning, Computer-Assisted -- methods KW - Yttrium Radioisotopes -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856409379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+quarterly+journal+of+nuclear+medicine+and+molecular+imaging+%3A+official+publication+of+the+Italian+Association+of+Nuclear+Medicine+%28AIMN%29+%5Band%5D+the+International+Association+of+Radiopharmacology+%28IAR%29%2C+%5Band%5D+Section+of+the+Society+of...&rft.atitle=Need%2C+feasibility+and+convenience+of+dosimetric+treatment+planning+in+liver+selective+internal+radiation+therapy+with+%2890%29Y+microspheres%3A+the+experience+of+the+National+Tumor+Institute+of+Milan.&rft.au=Chiesa%2C+C%3BMaccauro%2C+M%3BRomito%2C+R%3BSpreafico%2C+C%3BPellizzari%2C+S%3BNegri%2C+A%3BSposito%2C+C%3BMorosi%2C+C%3BCivelli%2C+E%3BLanocita%2C+R%3BCamerini%2C+T%3BBampo%2C+C%3BBhoori%2C+S%3BSeregni%2C+E%3BMarchian%C3%B2%2C+A%3BMazzaferro%2C+V%3BBombardieri%2C+E&rft.aulast=Chiesa&rft.aufirst=C&rft.date=2011-04-01&rft.volume=55&rft.issue=2&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=The+quarterly+journal+of+nuclear+medicine+and+molecular+imaging+%3A+official+publication+of+the+Italian+Association+of+Nuclear+Medicine+%28AIMN%29+%5Band%5D+the+International+Association+of+Radiopharmacology+%28IAR%29%2C+%5Band%5D+Section+of+the+Society+of...&rft.issn=18244785&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-30 N1 - Date created - 2011-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Serotonin (5-HT) precursor loading with 5-hydroxy-l-tryptophan (5-HTP) reduces locomotor activation produced by (+)-amphetamine in the rat AN - 1761652653; 201112791 AB - Evidence suggests that increases in synaptic serotonin (5-HT) can reduce the stimulant properties of amphetamine-type drugs. Here we tested the hypothesis that administration of the 5-HT precursor 5-hydroxy-l-tryptophan (5-HTP), along with the peripheral decarboxylase inhibitor benserazide, would decrease locomotor effects of (+)-amphetamine. Methods: Drug treatments were administered to conscious male rats undergoing in vivo microdialysis in nucleus accumbens. During dialysis sampling, rats were housed in chambers equipped with photobeams to detect forward locomotion (i.e., ambulation) and repetitive movements (i.e., stereotypy). Extracellular concentrations of dopamine (DA) and 5-HT were measured by high-pressure liquid chromatography with electrochemical detection. Results: 5-HTP (10 & 30 mg/kg, i.p.) plus benserazide (30 mg/kg, i.p.) caused dose-related increases in 5-HT but failed to alter other parameters. (+)-Amphetamine (0.3 & 1.0 mg/kg, i.p.) produced dose-related increases in DA, ambulation and stereotypy. Combined administration of 5-HTP and (+)-amphetamine evoked large elevations in extracellular da and 5-HT, but caused significantly less ambulation than (+)-amphetamine alone (50% reduction). Conclusions: Our results confirm that 5-HTP can decrease hyperactivity produced by (+)-amphetamine, even in the presence of elevations in dialysate DA. The data suggest that 5-HTP and (+)-amphetamine may be useful to broadly enhance monoamine function in the clinical setting, while reducing undesirable effects of (+)-amphetamine. [Copyright Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Baumann, Michael H AU - Williams, Zakia AU - Zolkowska, Dorota AU - Rothman, Richard B AD - Clinical Psychopharmacology Section, IRP, NIDA, NIH, 333 Cassell Drive, Baltimore, MD 21224, United States Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 147 EP - 152 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 114 IS - 2-3 SN - 0376-8716, 0376-8716 KW - Amphetamine 5-Hydroxy-l-tryptophan Cocaine Drug addiction Dopamine Serotonin KW - Rats KW - Precursors KW - Elevation KW - Sampling KW - Liquids KW - Serotonin KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761652653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Serotonin+%285-HT%29+precursor+loading+with+5-hydroxy-l-tryptophan+%285-HTP%29+reduces+locomotor+activation+produced+by+%28%2B%29-amphetamine+in+the+rat&rft.au=Baumann%2C+Michael+H%3BWilliams%2C+Zakia%3BZolkowska%2C+Dorota%3BRothman%2C+Richard+B&rft.aulast=Baumann&rft.aufirst=Michael&rft.date=2011-04-01&rft.volume=114&rft.issue=2-3&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2010.09.015 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Serotonin; Precursors; Elevation; Rats; Sampling; Liquids DO - http://dx.doi.org/10.1016/j.drugalcdep.2010.09.015 ER - TY - JOUR T1 - Improving Adoptive T Cell Therapy by Targeting and Controlling IL-12 Expression to the Tumor Environment AN - 1668268757; PQ0001269987 AB - Interleukin-12 (IL-12) is an important immunostimulatory cytokine, yet its clinical application has been limited by the systemic toxicity associated with its administration. In this work, we developed a strategy to selectively deliver IL-12 to the tumor environment using genetically engineered lymphocytes. However, peripheral blood lymphocytes (PBLs) transduced with a gamma -retroviral vector, which constitutively expressed IL-12, failed to expand in culture due to apoptosis. To circumvent this problem, a vector was designed where IL-12 expression was directed by a composite promoter-containing binding motifs for nuclear factor of activated T-cells (NFAT.hIL12.PA2). The NFAT-responsive promoter was activated to drive IL-12 expression upon the recognition of tumor-specific antigen mediated by a T cell receptor (TCR) that was engineered into the same lymphocytes. We tested the efficacy of the inducible IL-12 vector in vivo in a murine melanoma model. Adoptive transfer of pmel-1 T cells genetically engineered with NFAT-murinelL12 (NFAT. mIL12.PA2) significantly enhanced regression of large established B16 melanoma. Notably, this targeted and controlled IL-12 treatment was without toxicity. Taken together, our results suggest that using the NFAT.hIL12. PA2 vector might be a promising approach to enhance adoptive cancer immunotherapy. JF - Molecular Therapy AU - Zhang, Ling AU - Kerkar, Sid P AU - Yu, Zhiya AU - Zheng, Zhili AU - Yang, Shicheng AU - Restifo, Nicholas P AU - Rosenberg, Steven A AU - Morgan, Richard A AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA, rmorgan@mail.nih.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 751 EP - 759 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 19 IS - 4 SN - 1525-0016, 1525-0016 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - T-cell receptor KW - Apoptosis KW - Immunotherapy KW - Animal models KW - Therapeutic applications KW - Peripheral blood KW - Cell culture KW - Tumors KW - Toxicity KW - Cancer KW - Melanoma KW - Expression vectors KW - Promoters KW - Interleukin 12 KW - Immunostimulation KW - Genetic engineering KW - Lymphocytes T KW - Adoptive transfer KW - NF-AT protein KW - W 30925:Genetic Engineering KW - F 06960:Molecular Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668268757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=Improving+Adoptive+T+Cell+Therapy+by+Targeting+and+Controlling+IL-12+Expression+to+the+Tumor+Environment&rft.au=Zhang%2C+Ling%3BKerkar%2C+Sid+P%3BYu%2C+Zhiya%3BZheng%2C+Zhili%3BYang%2C+Shicheng%3BRestifo%2C+Nicholas+P%3BRosenberg%2C+Steven+A%3BMorgan%2C+Richard+A&rft.aulast=Zhang&rft.aufirst=Ling&rft.date=2011-04-01&rft.volume=19&rft.issue=4&rft.spage=751&rft.isbn=&rft.btitle=&rft.title=Molecular+Therapy&rft.issn=15250016&rft_id=info:doi/10.1038%2Fmt.2010.313 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - T-cell receptor; Apoptosis; Immunotherapy; Animal models; Therapeutic applications; Cell culture; Peripheral blood; Toxicity; Tumors; Cancer; Melanoma; Expression vectors; Interleukin 12; Promoters; Genetic engineering; Immunostimulation; Adoptive transfer; Lymphocytes T; NF-AT protein DO - http://dx.doi.org/10.1038/mt.2010.313 ER - TY - JOUR T1 - The skin microbiome AN - 1020835835; 14534216 AB - The skin is the human body's largest organ, colonized by a diverse milieu of microorganisms, most of which are harmless or even beneficial to their host. Colonization is driven by the ecology of the skin surface, which is highly variable depending on topographical location, endogenous host factors and exogenous environmental factors. The cutaneous innate and adaptive immune responses can modulate the skin microbiota, but the microbiota also functions in educating the immune system. The development of molecular methods to identify microorganisms has led to an emerging view of the resident skin bacteria as highly diverse and variable. An enhanced understanding of the skin microbiome is necessary to gain insight into microbial involvement in human skin disorders and to enable novel promicrobial and antimicrobial therapeutic approaches for their treatment. JF - Nature Reviews: Microbiology AU - Grice, Elizabeth A AU - Segre, Julia A AD - Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892-4442, USA. Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 244 EP - 253 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 9 IS - 4 SN - 1740-1526, 1740-1526 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Colonization KW - Skin KW - Immune system KW - Microorganisms KW - Immune response KW - Environmental factors KW - Antimicrobial agents KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020835835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Microbiology&rft.atitle=The+skin+microbiome&rft.au=Grice%2C+Elizabeth+A%3BSegre%2C+Julia+A&rft.aulast=Grice&rft.aufirst=Elizabeth&rft.date=2011-04-01&rft.volume=9&rft.issue=4&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Microbiology&rft.issn=17401526&rft_id=info:doi/10.1038%2Fnrmicro2537 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Colonization; Skin; Immune system; Microorganisms; Immune response; Environmental factors; Antimicrobial agents DO - http://dx.doi.org/10.1038/nrmicro2537 ER - TY - JOUR T1 - The vaginal microbiome: new information about genital tract flora using molecular based techniques AN - 1017987778; 14518713 AB - Please cite this paper as: Lamont R, Sobel J, Akins R, Hassan S, Chaiworapongsa T, Kusanovic J, Romero R. The vaginal microbiome: new information about genital tract flora using molecular based techniques. BJOG 2011; 118:533-549. Vaginal microbiome studies provide information that may change the way we define vaginal flora. Normal flora appears dominated by one or two species of Lactobacillus. Significant numbers of healthy women lack appreciable numbers of vaginal lactobacilli. Bacterial vaginosis (BV) is not a single entity, but instead consists of different bacterial communities or profiles of greater microbial diversity than is evident from cultivation-dependent studies. BV should be considered a syndrome of variable composition that results in different symptoms, phenotypical outcomes, and responses to different antibiotic regimens. This information may help to elucidate the link between BV and infection-related adverse outcomes of pregnancy. JF - BJOG AU - Lamont, R F AU - Sobel, J D AU - Akins, R A AU - Hassan, S S AU - Chaiworapongsa, T AU - Kusanovic, J P AU - Romero, R AD - Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, MD and Detroit, MI, USA Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 533 EP - 549 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 118 IS - 5 SN - 1470-0328, 1470-0328 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Antibiotics KW - Genital microflora KW - Genital tract KW - Pregnancy KW - Vagina KW - Vaginosis KW - Lactobacillus KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017987778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BJOG&rft.atitle=The+vaginal+microbiome%3A+new+information+about+genital+tract+flora+using+molecular+based+techniques&rft.au=Lamont%2C+R+F%3BSobel%2C+J+D%3BAkins%2C+R+A%3BHassan%2C+S+S%3BChaiworapongsa%2C+T%3BKusanovic%2C+J+P%3BRomero%2C+R&rft.aulast=Lamont&rft.aufirst=R&rft.date=2011-04-01&rft.volume=118&rft.issue=5&rft.spage=533&rft.isbn=&rft.btitle=&rft.title=BJOG&rft.issn=14700328&rft_id=info:doi/10.1111%2Fj.1471-0528.2010.02840.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Document feature - figure 1 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Vagina; Antibiotics; Genital tract; Vaginosis; Genital microflora; Pregnancy; Lactobacillus DO - http://dx.doi.org/10.1111/j.1471-0528.2010.02840.x ER - TY - JOUR T1 - Quantitative T2* imaging of metastatic human breast cancer to brain in the nude rat at 3 T AN - 1017974601; 16700546 AB - This study uses quantitative T2* imaging to track ferumoxides-protamine sulfate (FEPro)-labeled MDA-MB-231BR-Luc (231BRL) human breast cancer cells that metastasize to the nude rat brain. Four cohorts of nude rats were injected intracardially with FEPro-labeled, unlabeled or tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)-treated (to induce apoptosis) 231BRL cells, or saline, in order to develop metastatic breast cancer in the brain. The heads of the rats were imaged serially over 3-4 weeks using gradient multi-echo and turbo spin-echo pulse sequences at 3 T with a solenoid receive-only 4-cm-diameter coil. Quantitative T2* maps of the whole brain were obtained by the application of single-exponential fitting to the signal intensity of T2* images, and the distribution of T2* values in brain voxels was calculated. MRI findings were correlated with Prussian blue staining and immunohistochemical staining for iron in breast cancer and macrophages. Quantitative analysis of T2* from brain voxels demonstrated a significant shift to lower values following the intracardiac injection of FEPro-labeled 231BRL cells, relative to animals receiving unlabeled cells, apoptotic cells or saline. Quartile analysis based on the T2* distribution obtained from brain voxels demonstrated significant differences (p<0.0083) in the number of voxels with T2* values in the ranges 10-35ms (Q1), 36-60ms (Q2) and 61-86ms (Q3) from 1 day to 3 weeks post-infusion of labeled 231BRL cells, compared with baseline scans. There were no significant differences in the distribution of T2* obtained from serial MRI in rats receiving unlabeled or TRAIL-treated cells or saline. Histologic analysis demonstrated isolated Prussian blue-positive breast cancer cells scattered in the brains of rats receiving labeled cells, relative to animals receiving unlabeled or apoptotic cells. Quantitative T2* analysis of FEPro-labeled metastasized cancer cells was possible even after the hypointense voxels were no longer visible on T2*-weighted images. Published in 2010 by John Wiley & Sons, Ltd. JF - NMR in Biomedicine AU - Song, Ho-Taek AU - Jordan, Elaine K AU - Lewis, Bobbi K AU - Gold, Eric AU - Liu, Wei AU - Frank, Joseph A AD - Frank Laboratory, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, USA, hotsong@yuhs.ac Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 325 EP - 334 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 24 IS - 3 SN - 1099-1492, 1099-1492 KW - Biotechnology and Bioengineering Abstracts KW - Apoptosis KW - Brain KW - Brain mapping KW - Breast cancer KW - Heads KW - Iron KW - Macrophages KW - Magnetic resonance imaging KW - Metastases KW - N.M.R. KW - Neuroimaging KW - Sulfate KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017974601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=Quantitative+T2*+imaging+of+metastatic+human+breast+cancer+to+brain+in+the+nude+rat+at+3+T&rft.au=Song%2C+Ho-Taek%3BJordan%2C+Elaine+K%3BLewis%2C+Bobbi+K%3BGold%2C+Eric%3BLiu%2C+Wei%3BFrank%2C+Joseph+A&rft.aulast=Song&rft.aufirst=Ho-Taek&rft.date=2011-04-01&rft.volume=24&rft.issue=3&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=10991492&rft_id=info:doi/10.1002%2Fnbm.1596 L2 - http://onlinelibrary.wiley.com/doi/10.1002/nbm.1596/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Heads; Macrophages; Metastases; Brain mapping; Neuroimaging; Apoptosis; Magnetic resonance imaging; Brain; Breast cancer; N.M.R.; Iron; Sulfate DO - http://dx.doi.org/10.1002/nbm.1596 ER - TY - JOUR T1 - Four-chamber view and 'swing technique' (FAST) echo: a novel and simple algorithm to visualize standard fetal echocardiographic planes AN - 1017970316; 16703859 AB - Objective To describe a novel and simple algorithm (four-chamber view and 'swing technique' (FAST) echo) for visualization of standard diagnostic planes of fetal echocardiography from dataset volumes obtained with spatiotemporal image correlation (STIC) and applying a new display technology (OmniView). Methods We developed an algorithm to image standard fetal echocardiographic planes by drawing four dissecting lines through the longitudinal view of the ductal arch contained in a STIC volume dataset. Three of the lines are locked to provide simultaneous visualization of targeted planes, and the fourth line (unlocked) 'swings' through the ductal arch image (swing technique), providing an infinite number of cardiac planes in sequence. Each line generates the following plane(s): (a) Line 1: three-vessels and trachea view; (b) Line 2: five-chamber view and long-axis view of the aorta (obtained by rotation of the five-chamber view on the y-axis); (c) Line 3: four-chamber view; and (d) 'swing line': three-vessels and trachea view, five-chamber view and/or long-axis view of the aorta, four-chamber view and stomach. The algorithm was then tested in 50 normal hearts in fetuses at 15.3-40 weeks' gestation and visualization rates for cardiac diagnostic planes were calculated. To determine whether the algorithm could identify planes that departed from the normal images, we tested the algorithm in five cases with proven congenital heart defects. Results In normal cases, the FAST echo algorithm (three locked lines and rotation of the five-chamber view on the y-axis) was able to generate the intended planes (longitudinal view of the ductal arch, pulmonary artery, three-vessels and trachea view, five-chamber view, long-axis view of the aorta, four-chamber view) individually in 100% of cases (except for the three-vessels and trachea view, which was seen in 98% (49/50)) and simultaneously in 98% (49/50). The swing technique was able to generate the three-vessels and trachea view, five-chamber view and/or long-axis view of the aorta, four-chamber view and stomach in 100% of normal cases. In the abnormal cases, the FAST echo algorithm demonstrated the cardiac defects and displayed views that deviated from what was expected from the examination of normal hearts. The swing technique was useful for demonstrating the specific diagnosis due to visualization of an infinite number of cardiac planes in sequence. Conclusions This novel and simple algorithm can be used to visualize standard fetal echocardiographic planes in normal fetal hearts. The FAST echo algorithm may simplify examination of the fetal heart and could reduce operator dependency. Using this algorithm, inability to obtain expected views or the appearance of abnormal views in the generated planes should raise the index of suspicion for congenital heart disease. JF - Ultrasound in Obstetrics and Gynecology AU - Yeo, L AU - Romero, R AU - Jodicke, C AU - Ogge, G AU - Lee, W AU - Kusanovic, J P AU - Vaisbuch, E AU - Hassan, S AD - Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD and Detroit, MI, USA, lyeo@med.wayne.edu Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 423 EP - 431 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 37 IS - 4 SN - 1469-0705, 1469-0705 KW - Biotechnology and Bioengineering Abstracts KW - Algorithms KW - Aorta KW - Echocardiography KW - Fetuses KW - Gestation KW - Gynecology KW - Heart KW - Heart diseases KW - Obstetrics KW - Pulmonary artery KW - Stomach KW - Trachea KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017970316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=Four-chamber+view+and+%27swing+technique%27+%28FAST%29+echo%3A+a+novel+and+simple+algorithm+to+visualize+standard+fetal+echocardiographic+planes&rft.au=Yeo%2C+L%3BRomero%2C+R%3BJodicke%2C+C%3BOgge%2C+G%3BLee%2C+W%3BKusanovic%2C+J+P%3BVaisbuch%2C+E%3BHassan%2C+S&rft.aulast=Yeo&rft.aufirst=L&rft.date=2011-04-01&rft.volume=37&rft.issue=4&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=14690705&rft_id=info:doi/10.1002%2Fuog.8840 L2 - http://onlinelibrary.wiley.com/doi/10.1002/uog.8840/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Heart; Gynecology; Aorta; Echocardiography; Algorithms; Fetuses; Pulmonary artery; Gestation; Trachea; Ultrasound; Obstetrics; Stomach; Heart diseases DO - http://dx.doi.org/10.1002/uog.8840 ER - TY - JOUR T1 - Changing trends in antimicrobial resistance of major bacterial pathogens, 1985-2005: A study from a medical center in northern Taiwan AN - 1014100669; 14930952 AB - Background: Antimicrobial resistance is a major health problem worldwide. We evaluated the antimicrobial resistance trends of 16 major bacterial pathogens at a tertiary medical center in northern Taiwan. Methods: We conducted a retrospective review of annual summary documents for antimicrobial susceptibility of clinically isolated gram-positive and gram-negative bacteria from 1985 to 2005. The numbers of isolates and susceptibilities were calculated for three 7-year periods: first period, 1985-1991; second period, 1992-1998; and the third period, 1999-2005. Results: During the 21-year period, 219,715 bacterial pathogens were identified. A significant increase in incidence over time was found for methicillin-resistant Staphylococcus aureus methidllin-resistant S epidermidis, penicillin-nonsusceptible Streptococcus pneumoniae, eryth-romycin-resistant Spneumoniae, vancomycin-resistant enterococci, cefotaxime/ceftriaxone-resistant Escherichia coli and Klebsiella pneumoniae, and imipenem-resistant Acinetobacter baumannii. Additionally, a significant increase in ciprofloxacin resistance rates over time from 1996 to 2005 was noted for E coli, Enterobacter cloacae, and A baumannii (through 1997 to 2005). However, a significant decrease in erythromycin resistance rate with time from 1999 to 2005 was found for Groups A and B streptococci, non-A, B, D streptococci, and S pneumoniae. Conclusion: Resistance to antimicrobial agents increased rapidly in the past two decades in Taiwan and has become very common in major bacterial pathogens. Continuous enforcement of policies to limit use of antimicrobial agents and active surveillance of antimicrobial resistance through a nationwide system are both warranted. JF - Journal of Microbiology, Immunology and Infection AU - Lo, W-T AU - Lin, W-J AU - Chiueh, T-S AU - Lee, S-Y AU - Wang, C-C AU - Lu, J-J AD - Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, No. 325 Cheng-Kung Road, Section 2, Nei-hu 114, Taipei, Taiwan, ndmcccw@yahoo.com.tw Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 131 EP - 138 VL - 44 IS - 2 SN - 1684-1182, 1684-1182 KW - Microbiology Abstracts B: Bacteriology KW - Antimicrobial agents KW - Cefotaxime KW - Ciprofloxacin KW - Drug resistance KW - Erythromycin KW - Gram-negative bacteria KW - Pathogens KW - Reviews KW - Enterobacter cloacae KW - Streptococcus pneumoniae KW - Acinetobacter baumannii KW - Escherichia coli KW - Staphylococcus aureus KW - Klebsiella pneumoniae KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1014100669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Microbiology%2C+Immunology+and+Infection&rft.atitle=Changing+trends+in+antimicrobial+resistance+of+major+bacterial+pathogens%2C+1985-2005%3A+A+study+from+a+medical+center+in+northern+Taiwan&rft.au=Lo%2C+W-T%3BLin%2C+W-J%3BChiueh%2C+T-S%3BLee%2C+S-Y%3BWang%2C+C-C%3BLu%2C+J-J&rft.aulast=Lo&rft.aufirst=W-T&rft.date=2011-04-01&rft.volume=44&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Journal+of+Microbiology%2C+Immunology+and+Infection&rft.issn=16841182&rft_id=info:doi/10.1016%2Fj.jmii.2010.02.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-05-18 N1 - SubjectsTermNotLitGenreText - Ciprofloxacin; Cefotaxime; Reviews; Gram-negative bacteria; Drug resistance; Pathogens; Erythromycin; Antimicrobial agents; Streptococcus pneumoniae; Enterobacter cloacae; Acinetobacter baumannii; Escherichia coli; Staphylococcus aureus; Klebsiella pneumoniae DO - http://dx.doi.org/10.1016/j.jmii.2010.02.004 ER - TY - JOUR T1 - Microbiology: Dicing defence in bacteria AN - 1762352645; 14866307 JF - Nature AU - Gottesman, Susan AD - Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2011/03/31/ PY - 2011 DA - 2011 Mar 31 SP - 588 EP - 589 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 471 IS - 7340 SN - 0028-0836, 0028-0836 KW - Microbiology Abstracts B: Bacteriology KW - Bacteria KW - J 02490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762352645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Microbiology%3A+Dicing+defence+in+bacteria&rft.au=Gottesman%2C+Susan&rft.aulast=Gottesman&rft.aufirst=Susan&rft.date=2011-03-31&rft.volume=471&rft.issue=7340&rft.spage=588&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2F471588a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Bacteria DO - http://dx.doi.org/10.1038/471588a ER - TY - JOUR T1 - Progesterone induces expression of the prolactin receptor gene through cooperative action of Sp1 and C/EBP. AN - 853993522; 21238538 AB - Prolactin (Prl) and progesterone (P) cooperate synergistically during mammary gland development and tumorigenesis. We hypothesized that one mechanism for these effects may be through mutual induction of receptors (R). EpH4 mouse mammary epithelial cells stably transfected with PR-A express elevated levels of PrlR mRNA and protein compared to control EpH4 cells that lack the PR. Likewise, T47D human breast cancer cells treated with P overexpress the PrlR and activate PrlR promoter III. PrlR promoter III does not contain a classical P response element but contains several binding sites for transcription proteins, including C/EBP, Sp1 and AP1, which may also interact with the PR. Using promoter deletion and site directed mutagenesis analyses as well as gel shift assays, cooperative activation of the C/EBP and adjacent Sp1A, but not the Sp1B or AP1, sites by P is shown to confer P responsiveness leading to increased PrlR transcription. Published by Elsevier Ireland Ltd. JF - Molecular and cellular endocrinology AU - Goldhar, Anita S AU - Duan, Renqin AU - Ginsburg, Erika AU - Vonderhaar, Barbara K AD - Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, NCI, Bethesda, MD 20892-4254, USA. Y1 - 2011/03/30/ PY - 2011 DA - 2011 Mar 30 SP - 148 EP - 157 VL - 335 IS - 2 KW - CCAAT-Enhancer-Binding Proteins KW - 0 KW - Protein Isoforms KW - Receptors, Progesterone KW - Receptors, Prolactin KW - Recombinant Proteins KW - Sp1 Transcription Factor KW - Progesterone KW - 4G7DS2Q64Y KW - Luciferases KW - EC 1.13.12.- KW - Index Medicus KW - Animals KW - Recombinant Proteins -- biosynthesis KW - Humans KW - Protein Isoforms -- metabolism KW - Immunoprecipitation KW - Transcription, Genetic KW - Cell Line, Tumor KW - Mice KW - Recombinant Proteins -- genetics KW - Protein Binding KW - Luciferases -- biosynthesis KW - Up-Regulation -- drug effects KW - Genes, Reporter KW - Response Elements KW - Luciferases -- genetics KW - Protein Isoforms -- genetics KW - Cell Line KW - Progesterone -- physiology KW - Receptors, Prolactin -- metabolism KW - Receptors, Progesterone -- metabolism KW - Progesterone -- pharmacology KW - Sp1 Transcription Factor -- metabolism KW - CCAAT-Enhancer-Binding Proteins -- metabolism KW - Receptors, Prolactin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853993522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+endocrinology&rft.atitle=Progesterone+induces+expression+of+the+prolactin+receptor+gene+through+cooperative+action+of+Sp1+and+C%2FEBP.&rft.au=Goldhar%2C+Anita+S%3BDuan%2C+Renqin%3BGinsburg%2C+Erika%3BVonderhaar%2C+Barbara+K&rft.aulast=Goldhar&rft.aufirst=Anita&rft.date=2011-03-30&rft.volume=335&rft.issue=2&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+endocrinology&rft.issn=1872-8057&rft_id=info:doi/10.1016%2Fj.mce.2011.01.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-20 N1 - Date created - 2011-02-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1997 Nov 14;272(46):29120-6 [9360988] J Clin Endocrinol Metab. 1997 Nov;82(11):3692-9 [9360527] Mol Endocrinol. 2000 Mar;14(3):359-68 [10707954] Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3044-9 [10737785] Horm Res. 2000;54(1):32-7 [11182633] Mol Endocrinol. 2001 Feb;15(2):228-40 [11158330] Dev Dyn. 2001 Oct;222(2):192-205 [11668597] J Biol Chem. 2001 Nov 2;276(44):41086-94 [11518703] Breast Cancer Res Treat. 2002 Mar;72(2):163-72 [12038707] J Biol Chem. 2002 Aug 2;277(31):27793-800 [12021276] J Mammary Gland Biol Neoplasia. 2002 Jan;7(1):17-38 [12160083] Cancer Res. 2002 Aug 15;62(16):4781-90 [12183438] Mol Endocrinol. 2002 Dec;16(12):2675-91 [12456789] J Mol Endocrinol. 2003 Feb;30(1):31-47 [12580759] Endocr Rev. 2003 Feb;24(1):1-27 [12588805] Anal Biochem. 1976 May 7;72:248-54 [942051] Endocrinology. 1979 May;104(5):1447-9 [220036] J Dairy Sci. 1985 Feb;68(2):466-88 [2985666] J Clin Endocrinol Metab. 1986 Feb;62(2):280-7 [3001123] Jpn J Cancer Res. 1987 Oct;78(10):1105-11 [3119544] J Soc Gynecol Investig. 1998 May-Jun;5(3):149-55 [9614645] Genes Dev. 1998 Jun 15;12(12):1917-28 [9637692] J Biol Chem. 1998 Oct 2;273(40):26225-35 [9748306] DNA Cell Biol. 1998 Sep;17(9):761-70 [9778035] J Clin Endocrinol Metab. 1999 Mar;84(3):1153-6 [10084611] Genes Dev. 1999 Sep 1;13(17):2231-41 [10485846] Mol Cell Endocrinol. 2005 Mar 31;232(1-2):9-19 [15737464] Endocrinology. 2005 Aug;146(8):3577-88 [15878961] J Biol Chem. 2006 Jul 7;281(27):18825-36 [16651265] Mol Cell Biol. 2007 Jan;27(2):466-80 [17074804] Cancer Res. 2007 Sep 15;67(18):8942-51 [17875737] Oncogene. 2007 Nov 29;26(54):7526-34 [17546050] Mol Cell Endocrinol. 2008 Jan 16;281(1-2):9-18 [18022314] Crit Rev Eukaryot Gene Expr. 2008;18(1):11-33 [18197783] Mol Endocrinol. 2008 Apr;22(4):823-37 [18202149] Adv Exp Med Biol. 2008;630:94-111 [18637487] J Mol Endocrinol. 2008 Aug;41(2):75-90 [18524869] J Mol Endocrinol. 2009 Jan;42(1):19-33 [18952783] Oncogene. 2009 Mar 12;28(10):1298-308 [19169277] Steroids. 2009 Jul;74(7):568-72 [19135465] J Biol Chem. 2009 Oct 16;284(42):28607-15 [19652226] Nucl Recept Signal. 2009;7:e009 [20087430] Mol Endocrinol. 1989 Apr;3(4):674-80 [2725531] Anticancer Res. 1989 May-Jun;9(3):631-6 [2764510] Cell. 1992 Dec 24;71(7):1103-16 [1473147] Cancer Res. 1995 Nov 1;55(21):5063-8 [7585552] J Biol Chem. 1996 Apr 26;271(17):10242-6 [8626590] Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):6169-74 [8650238] Mol Endocrinol. 1996 Jun;10(6):661-71 [8776726] J Biol Chem. 1998 Apr 24;273(17):10696-701 [9553133] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mce.2011.01.004 ER - TY - JOUR T1 - Strengthening biostatistics resources in sub-Saharan Africa: Research collaborations through U.S. partnerships AN - 1520378558; 16691064 AB - On September 30, 2009, the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) conducted a workshop on strengthening biostatistics resources in sub-Saharan Africa (SSA). An increase in global spending on health research over the last decade has boosted funds available to conduct biomedical research in low- to mid-income countries. The HIV/AIDS pandemic, the re-emergence of malaria and tuberculosis, and other emerging infectious agents are major driving forces behind the increase in biomedical research and clinical care programs (clinical trials, observational studies and, other public health programs) in SSA (Exp. Biol. Med. 2008; 233:277-285). In addition, the increased engagement of the United States (U.S.) government through the Global Health Initiative, which expands the traditional focus beyond infectious diseases to other causes of poor health and to the recognition of need the to strengthen health systems for a sustainable response, only increases the need for in-depth in-country expertise in all aspects of biomedical research (White House Press Release, 2009). In this workshop, researchers both from the U.S. and SSA were invited to discuss their collaborative work, to discuss ways in which biostatistical activities are carried out within their research projects, and to identify both general and specific needs for capacity building in biostatistics. Capacity building discussions highlighted the critical need to increase the number of well-trained in-country biostatisticians, both to participate in ongoing studies and to contribute to an infrastructure that can produce the next generation of biostatistical researchers. JF - Statistics in Medicine AU - Gezmu, Misrak AU - Degruttola, Victor AU - Dixon, Dennis AU - Essex, Max AU - Halloran, Elizabeth AU - Hogan, Joseph AU - Grobler, Anneke AU - Kim, Soyeon AU - McDermott, Jeanne AU - McKaig, Rosemary AU - Neaton, James D AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, U.S.A., mgezmu@niaid.nih.gov Y1 - 2011/03/30/ PY - 2011 DA - 2011 Mar 30 SP - 695 EP - 708 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 30 IS - 7 SN - 1097-0258, 1097-0258 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Allergic reactions KW - USA KW - Human diseases KW - Infectious diseases KW - Human immunodeficiency virus KW - Mycobacterium KW - Africa KW - Tuberculosis KW - Malaria KW - Public health KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520378558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistics+in+Medicine&rft.atitle=Strengthening+biostatistics+resources+in+sub-Saharan+Africa%3A+Research+collaborations+through+U.S.+partnerships&rft.au=Gezmu%2C+Misrak%3BDegruttola%2C+Victor%3BDixon%2C+Dennis%3BEssex%2C+Max%3BHalloran%2C+Elizabeth%3BHogan%2C+Joseph%3BGrobler%2C+Anneke%3BKim%2C+Soyeon%3BMcDermott%2C+Jeanne%3BMcKaig%2C+Rosemary%3BNeaton%2C+James+D&rft.aulast=Gezmu&rft.aufirst=Misrak&rft.date=2011-03-30&rft.volume=30&rft.issue=7&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Statistics+in+Medicine&rft.issn=10970258&rft_id=info:doi/10.1002%2Fsim.4144 L2 - http://onlinelibrary.wiley.com/doi/10.1002/sim.4144/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Allergic reactions; Human diseases; Infectious diseases; Malaria; Tuberculosis; Public health; Mycobacterium; Human immunodeficiency virus; USA; Africa DO - http://dx.doi.org/10.1002/sim.4144 ER - TY - JOUR T1 - Markers of endothelial dysfunction, coagulation and tissue fibrosis independently predict venous thromboembolism in HIV AN - 864956031; 14690440 AB - Objective: HIV infection is associated with coagulation abnormalities and significantly increased risk of venous thrombosis. It has been shown that higher plasma levels of coagulation and inflammatory biomarkers predicted mortality in HIV. We investigated the relationship between venous thrombosis and HIV-related characteristics, traditional risk factors of hypercoagulability, and pre-event levels of biomarkers. Design: A retrospective case-control study of 23 HIV-infected individuals who experienced an incidentvenousthromboemboliceventwhile enrolled in National Institutes of Health studies from 1995 to 2010 and 69 age-matched and sex-matched HIV-infected individuals without known venous thromboembolism (VTE). Methods: Biomarkers of inflammation, endothelial dysfunction, coagulation, tissue fibrosis, and cytomegalovirus (CMV) reactivation were assessed by ELISA-based assays and PCR using plasma obtained prior to the event. Results: VTE events were related to nadir CD4 cell count, lifetime history of multiple opportunistic infections, CMV disease, CMV viremia, immunological AIDS, active infection, and provocation (i.e., recent hospitalization, surgery, or trauma). VTE events were independently associated with increased plasma levels of P-selectin (P = 0.002), D-dimer (P = 0.01), and hyaluronic acid (P = 0.009) in a multivariate analysis. No significant differences in antiretroviral or interleukin-2 exposures, plasma HIV viremia, or other traditional risk factors were observed. Conclusion: Severe immunodeficiency, active infection, and provocation are associated with venous thromboembolic disease in HIV. Biomarkers of endothelial dysfunction, coagulation, and tissue fibrosis may help identify HIV-infected patients at elevated risk of VTE. JF - AIDS AU - Musselwhite, L W AU - Sheikh, V AU - Norton, T D AU - Rupert, A AU - Porter, BO AU - Penzak AU - Skinner, J AU - Mican, JAM AU - Hadigan, C AU - Sereti, I AD - National Institutes of Health, 10 Center Drive, Building 10, Room 11B07A, Bethesda, MD 20892, USA, isereti@niaid.nih.gov Y1 - 2011/03/27/ PY - 2011 DA - 2011 Mar 27 SP - 787 EP - 795 PB - Rapid Science Publishers, The Old Malthouse Paradise St. Oxford OX1 1LD UK, [mailto:rapid@rapidcom.co.ukmarketing@rapidcom.co.uk] VL - 25 IS - 6 SN - 0269-9370, 0269-9370 KW - Risk Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - Tissues KW - Acquired immune deficiency syndrome KW - Interleukin 2 KW - Fibrosis KW - Immunodeficiency KW - P-selectin KW - Cytomegalovirus KW - surgery KW - Thromboembolism KW - CD4 antigen KW - Antiviral agents KW - Multivariate analysis KW - Risk factors KW - Surgery KW - infection KW - Polymerase chain reaction KW - Bioindicators KW - Mortality KW - Hyaluronic acid KW - thromboembolism KW - Coagulation KW - biomarkers KW - Thrombosis KW - Inflammation KW - Opportunist infection KW - Trauma KW - Plasma levels KW - Human immunodeficiency virus KW - Viremia KW - V 22360:AIDS and HIV KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864956031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Markers+of+endothelial+dysfunction%2C+coagulation+and+tissue+fibrosis+independently+predict+venous+thromboembolism+in+HIV&rft.au=Musselwhite%2C+L+W%3BSheikh%2C+V%3BNorton%2C+T+D%3BRupert%2C+A%3BPorter%2C+BO%3BPenzak%3BSkinner%2C+J%3BMican%2C+JAM%3BHadigan%2C+C%3BSereti%2C+I&rft.aulast=Musselwhite&rft.aufirst=L&rft.date=2011-03-27&rft.volume=25&rft.issue=6&rft.spage=787&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0b013e3283453fcb LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Hyaluronic acid; Mortality; Acquired immune deficiency syndrome; Interleukin 2; Coagulation; Fibrosis; Immunodeficiency; P-selectin; biomarkers; Thromboembolism; Thrombosis; Trauma; Opportunist infection; Inflammation; Plasma levels; CD4 antigen; Antiviral agents; Multivariate analysis; Surgery; Risk factors; Polymerase chain reaction; Viremia; Bioindicators; Tissues; thromboembolism; Human immunodeficiency virus; infection; surgery; Cytomegalovirus DO - http://dx.doi.org/10.1097/QAD.0b013e3283453fcb ER - TY - CPAPER T1 - CTCF Dysfunction, Epigenetic Deregulation, and Cancer Susceptibility T2 - 2011 Keystone Symposia on Environmental Epigenomics and Disease Susceptibility (D3) AN - 1312995593; 6065563 JF - 2011 Keystone Symposia on Environmental Epigenomics and Disease Susceptibility (D3) AU - Lobanenkov, Victor Y1 - 2011/03/27/ PY - 2011 DA - 2011 Mar 27 KW - Cancer KW - deregulation KW - epigenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312995593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Environmental+Epigenomics+and+Disease+Susceptibility+%28D3%29&rft.atitle=CTCF+Dysfunction%2C+Epigenetic+Deregulation%2C+and+Cancer+Susceptibility&rft.au=Lobanenkov%2C+Victor&rft.aulast=Lobanenkov&rft.aufirst=Victor&rft.date=2011-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Environmental+Epigenomics+and+Disease+Susceptibility+%28D3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1120&CFID=359719&CFTOKEN=59392927 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - The crystal structure of BamB suggests interactions with BamA and its role within the BAM complex. AN - 855204320; 21277859 AB - Escherichia coli BamB is the largest of four lipoproteins in the β-barrel assembly machinery (BAM) complex. It interacts with the periplasmic domain of BamA, an integral outer membrane protein (OMP) essential for OMP biogenesis. Although BamB is not essential, it serves an important function in the BAM complex, significantly increasing the folding efficiency of some OMPs in vivo and in vitro. To learn more about the BAM complex, we solved structures of BamB in three different crystal forms. BamB crystallized in space groups P2(1)3, I222, and P2(1)2(1)2(1), with one molecule per asymmetric unit in each case. Crystals from the space group I222 diffracted to 1. 65-Å resolution. BamB forms an eight-bladed β-propeller with a central pore and is shaped like a doughnut. A DALI search revealed that BamB shares structural homology to several eukaryotic proteins containing WD40 repeat domains, which commonly have β-propeller folds and often serve as scaffolding proteins within larger multi-protein complexes that carry out signal transduction, cell division, and chemotaxis. Using mutagenesis data from previous studies, we docked BamB onto a BamA structural model and assessed known and possible interactions between these two proteins. Our data suggest that BamB serves as a scaffolding protein within the BAM complex by optimally orienting the flexible periplasmic domain of BamA for interaction with other BAM components and chaperones. This may facilitate integration of newly synthesized OMPs into the outer membrane. Published by Elsevier Ltd. JF - Journal of molecular biology AU - Noinaj, Nicholas AU - Fairman, James W AU - Buchanan, Susan K AD - Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-8030, USA. Y1 - 2011/03/25/ PY - 2011 DA - 2011 Mar 25 SP - 248 EP - 260 VL - 407 IS - 2 KW - Bacterial Outer Membrane Proteins KW - 0 KW - BamB protein, E coli KW - Escherichia coli Proteins KW - Lipoproteins KW - Index Medicus KW - Protein Structure, Secondary KW - Models, Molecular KW - Protein Folding KW - Crystallography KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Protein Structure, Tertiary KW - Molecular Weight KW - Escherichia coli Proteins -- chemistry KW - Lipoproteins -- metabolism KW - Escherichia coli Proteins -- metabolism KW - Bacterial Outer Membrane Proteins -- metabolism KW - Bacterial Outer Membrane Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855204320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=The+crystal+structure+of+BamB+suggests+interactions+with+BamA+and+its+role+within+the+BAM+complex.&rft.au=Noinaj%2C+Nicholas%3BFairman%2C+James+W%3BBuchanan%2C+Susan+K&rft.aulast=Noinaj&rft.aufirst=Nicholas&rft.date=2011-03-25&rft.volume=407&rft.issue=2&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=1089-8638&rft_id=info:doi/10.1016%2Fj.jmb.2011.01.042 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-13 N1 - Date created - 2011-03-04 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 3Q7M; PDB; 3Q7N; 3Q7O N1 - SuppNotes - Cited By: J Bacteriol. 2007 Jan;189(2):446-54 [17071751] J Mol Biol. 2011 Mar 11;406(5):667-78 [21168416] Bioinformatics. 2001 Apr;17(4):377-8 [11301311] J Biol Chem. 2001 Apr 20;276(16):13072-6 [11278884] Acta Crystallogr D Biol Crystallogr. 2002 Nov;58(Pt 11):1948-54 [12393927] Proteins. 2003 Jul 1;52(1):80-7 [12784371] Methods Enzymol. 1989;172:514-28 [2546016] Microbiol Rev. 1993 Mar;57(1):50-108 [8096622] Nature. 1994 Sep 22;371(6495):297-300 [8090199] J Mol Graph. 1996 Dec;14(6):354-60, 376 [9195488] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] Cell. 2005 Apr 22;121(2):235-45 [15851030] Cell. 2005 Apr 22;121(2):307-17 [15851036] J Bacteriol. 2005 Jul;187(13):4552-61 [15968066] J Mol Biol. 2005 Aug 26;351(4):923-35 [16051270] J Mol Biol. 2005 Sep 9;352(1):91-104 [16061256] Mol Microbiol. 2006 Jul;61(1):151-64 [16824102] J Bacteriol. 2006 Oct;188(20):7186-94 [17015657] PLoS Biol. 2006 Nov;4(11):e377 [17090219] Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6400-5 [17404237] Science. 2007 Aug 17;317(5840):957-61 [17702945] Science. 2007 Aug 17;317(5840):961-4 [17702946] Biocell. 2007 Aug;31(2):213-23 [17902269] J Bacteriol. 2008 Mar;190(5):1507-17 [18165306] Mol Microbiol. 2008 Jun;68(5):1216-27 [18430136] Protein Sci. 2008 Oct;17(10):1771-80 [18715992] Subcell Biochem. 2008;48:20-30 [18925368] FEMS Microbiol Rev. 2008 Nov;32(6):995-1009 [18759741] Structure. 2008 Dec 10;16(12):1873-81 [19081063] Nat Rev Microbiol. 2009 Mar;7(3):206-14 [19182809] BMC Bioinformatics. 2009;10:32 [19166624] Bioinformatics. 2009 May 1;25(9):1189-91 [19151095] Cell Mol Life Sci. 2009 Sep;66(17):2789-804 [19399587] Cell. 2009 Aug 21;138(4):628-44 [19703392] Science. 2010 May 14;328(5980):890-2 [20378773] Trends Biochem Sci. 2010 Oct;35(10):565-74 [20451393] Structure. 2010 Nov 10;18(11):1492-501 [21070948] EMBO J. 2010 Nov 17;29(22):3750-61 [20940704] Microbiology. 2000 Dec;146 Pt 12:3259-67 [11101684] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jmb.2011.01.042 ER - TY - JOUR T1 - Structural evolution of Iowa mutant β-amyloid fibrils from polymorphic to homogeneous states under repeated seeded growth. AN - 857816593; 21355554 AB - Structural variations in β-amyloid fibrils are potentially important to the toxicity of these fibrils in Alzheimer's disease (AD). We describe a repeated seeding protocol that selects a homogeneous fibril structure from a polymorphic initial state in the case of 40-residue β-amyloid fibrils with the Asp23-to-Asn, or Iowa, mutation (D23N-Aβ(1-40)). We use thioflavin T (ThT) fluorescence, transmission electron microscopy (TEM), and solid-state nuclear magnetic resonance (NMR) to track the evolution of fibril structure through multiple generations under this protocol. The data show that (i) repeated seeding selectively amplifies a single D23N-Aβ(1-40) fibril structure that can be a minor component of the initial polymorphic state; (ii) the final structure is highly sensitive to growth conditions, including pH, temperature, and agitation; (iii) although the initial state can include fibrils that contain both antiparallel and parallel β-sheets, the final structures contain only parallel β-sheets, suggesting that antiparallel β-sheet structures are thermodynamically and kinetically metastable. Additionally, our data demonstrate that ThT fluorescence enhancements, which are commonly used to monitor amyloid fibril formation, vary strongly with structural variations, even among fibrils comprised of the same polypeptide. Finally, we present a simple mathematical model that describes the structural evolution of fibril samples under repeated seeding. JF - Journal of the American Chemical Society AU - Qiang, Wei AU - Yau, Wai-Ming AU - Tycko, Robert AD - Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, United States. Y1 - 2011/03/23/ PY - 2011 DA - 2011 Mar 23 SP - 4018 EP - 4029 VL - 133 IS - 11 KW - Amyloid beta-Peptides KW - 0 KW - Thiazoles KW - thioflavin T KW - 2390-54-7 KW - Index Medicus KW - Microscopy, Electron, Transmission KW - Thermodynamics KW - Spectrometry, Fluorescence KW - Nuclear Magnetic Resonance, Biomolecular KW - Kinetics KW - Hydrogen-Ion Concentration KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Protein Conformation KW - Amyloid beta-Peptides -- genetics KW - Amyloid beta-Peptides -- chemistry KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/857816593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Structural+evolution+of+Iowa+mutant+%CE%B2-amyloid+fibrils+from+polymorphic+to+homogeneous+states+under+repeated+seeded+growth.&rft.au=Qiang%2C+Wei%3BYau%2C+Wai-Ming%3BTycko%2C+Robert&rft.aulast=Qiang&rft.aufirst=Wei&rft.date=2011-03-23&rft.volume=133&rft.issue=11&rft.spage=4018&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=1520-5126&rft_id=info:doi/10.1021%2Fja109679q LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-28 N1 - Date created - 2011-03-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18349-54 [19015532] J Mol Biol. 2008 Dec 19;384(3):718-29 [18851978] Proc Natl Acad Sci U S A. 2009 May 5;106(18):7443-8 [19376973] Biochemistry. 2009 Jul 7;48(26):6072-84 [19358576] Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14339-44 [19706519] Science. 2009 Dec 11;326(5959):1533-7 [20007899] J Mol Biol. 2010 Jul 23;400(4):908-21 [20553730] J Am Chem Soc. 2010 Aug 4;132(30):10414-23 [20662519] J Mol Biol. 2010 Aug 20;401(3):503-17 [20600131] Biochemistry. 2010 Nov 9;49(44):9488-97 [20925423] J Neurochem. 2000 May;74(5):2209-12 [10800967] J Biol Chem. 2000 Sep 1;275(35):27110-6 [10821838] Biochemistry. 2000 Nov 14;39(45):13748-59 [11076514] Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13045-50 [11069287] Ann Neurol. 2001 Jun;49(6):697-705 [11409420] J Biol Chem. 2001 Aug 31;276(35):32860-6 [11441013] J Magn Reson. 2002 Apr;155(2):293-9 [12036340] Biophys J. 2002 Aug;83(2):1205-16 [12124300] J Biol Chem. 2002 Oct 25;277(43):40810-5 [12181315] Biochemistry. 2002 Dec 24;41(51):15436-50 [12484785] Neurobiol Dis. 2002 Nov;11(2):330-40 [12505425] J Biol Chem. 2003 Sep 26;278(39):37530-5 [12815044] J Mol Biol. 2004 Jan 2;335(1):247-60 [14659754] PLoS Biol. 2004 Oct;2(10):e321 [15383837] Biochemistry. 1992 Nov 10;31(44):10716-23 [1420187] J Biomol NMR. 1995 Jan;5(1):67-81 [7881273] Nat Struct Biol. 1995 Nov;2(11):990-8 [7583673] Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2996-3000 [8610157] J Mol Graph. 1996 Feb;14(1):51-5, 29-32 [8744573] Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13407-12 [9811813] Science. 2005 Jan 14;307(5707):262-5 [15653506] Biochemistry. 2005 Apr 26;44(16):6003-14 [15835889] Biochemistry. 2005 Aug 9;44(31):10669-80 [16060675] Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15871-6 [16247008] J Mol Biol. 2006 Jan 20;355(3):501-23 [16321400] Biochemistry. 2006 Jan 17;45(2):498-512 [16401079] Biophys J. 2006 Jun 15;90(12):4618-29 [16565054] Science. 2006 Sep 22;313(5794):1781-4 [16990547] Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15806-11 [17038504] Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19754-9 [17170131] J Am Chem Soc. 2007 Feb 7;129(5):1225-32 [17263405] Curr Opin Struct Biol. 2007 Feb;17(1):48-57 [17251001] J Chem Phys. 2007 Feb 14;126(6):064506 [17313228] Nature. 2007 May 24;447(7143):453-7 [17468747] Nature. 2007 Sep 13;449(7159):233-7 [17767153] Biochemistry. 2007 Nov 13;46(45):13149-62 [17953455] Biochemistry. 2007 Nov 27;46(47):13505-22 [17979302] Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18946-51 [18025469] Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2403-8 [18268327] Ann Neurol. 2008 Mar;63(3):377-87 [18300294] J Struct Biol. 2008 Jun;162(3):387-96 [18406172] Angew Chem Int Ed Engl. 2008;47(31):5842-5 [18528917] J Mol Biol. 2009 Jan 30;385(4):1052-63 [19038267] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ja109679q ER - TY - CPAPER T1 - CD8+ T Cell Public Clonotype Usage in a Single Epitope-Specific Response in Acute SIV Infection of Mamu-B*08 Positive Rhesus Macaques may Determine Control of Viral Replication T2 - 2011 Keystone Symposia on Protection from HIV: Targeted Intervention Strategies (X8) AN - 1313030730; 6064998 JF - 2011 Keystone Symposia on Protection from HIV: Targeted Intervention Strategies (X8) AU - de Almeida, Jorge Y1 - 2011/03/20/ PY - 2011 DA - 2011 Mar 20 KW - Infection KW - Replication KW - CD8 antigen KW - Lymphocytes T KW - Viral diseases KW - Macaca mulatta KW - Simian immunodeficiency virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313030730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Protection+from+HIV%3A+Targeted+Intervention+Strategies+%28X8%29&rft.atitle=CD8%2B+T+Cell+Public+Clonotype+Usage+in+a+Single+Epitope-Specific+Response+in+Acute+SIV+Infection+of+Mamu-B*08+Positive+Rhesus+Macaques+may+Determine+Control+of+Viral+Replication&rft.au=de+Almeida%2C+Jorge&rft.aulast=de+Almeida&rft.aufirst=Jorge&rft.date=2011-03-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Protection+from+HIV%3A+Targeted+Intervention+Strategies+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1110&CFID=359976&CFTOKEN=23323681 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - SIVmac239 DNA and Virus Particle Vaccination Confers Protection Upon Mucosal Challenge With Heterologous SIVsmE660 T2 - 2011 Keystone Symposia on Protection from HIV: Targeted Intervention Strategies (X8) AN - 1313030696; 6064997 JF - 2011 Keystone Symposia on Protection from HIV: Targeted Intervention Strategies (X8) AU - Felber, Barbara Y1 - 2011/03/20/ PY - 2011 DA - 2011 Mar 20 KW - Particulates KW - Vaccination KW - Mucosa UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313030696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Protection+from+HIV%3A+Targeted+Intervention+Strategies+%28X8%29&rft.atitle=SIVmac239+DNA+and+Virus+Particle+Vaccination+Confers+Protection+Upon+Mucosal+Challenge+With+Heterologous+SIVsmE660&rft.au=Felber%2C+Barbara&rft.aulast=Felber&rft.aufirst=Barbara&rft.date=2011-03-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Protection+from+HIV%3A+Targeted+Intervention+Strategies+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1110&CFID=359976&CFTOKEN=23323681 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Identification and Characterization of T Memory Stem Cells in Humans and NHP: Implication for Vaccine Design T2 - 2011 Keystone Symposia on Protection from HIV: Targeted Intervention Strategies (X8) AN - 1313020456; 6065004 JF - 2011 Keystone Symposia on Protection from HIV: Targeted Intervention Strategies (X8) AU - Roederer, Mario Y1 - 2011/03/20/ PY - 2011 DA - 2011 Mar 20 KW - vaccines KW - stem cells KW - Vaccines KW - Immunological memory KW - Stem cells KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313020456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Protection+from+HIV%3A+Targeted+Intervention+Strategies+%28X8%29&rft.atitle=Identification+and+Characterization+of+T+Memory+Stem+Cells+in+Humans+and+NHP%3A+Implication+for+Vaccine+Design&rft.au=Roederer%2C+Mario&rft.aulast=Roederer&rft.aufirst=Mario&rft.date=2011-03-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Protection+from+HIV%3A+Targeted+Intervention+Strategies+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1110&CFID=359976&CFTOKEN=23323681 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Determinants of Poor Immunogenicity of Alternative Adenoviruses T2 - 2011 Keystone Symposia on Protection from HIV: Targeted Intervention Strategies (X8) AN - 1313014517; 6064958 JF - 2011 Keystone Symposia on Protection from HIV: Targeted Intervention Strategies (X8) AU - Johnson, Matthew Y1 - 2011/03/20/ PY - 2011 DA - 2011 Mar 20 KW - immunogenicity KW - Immunogenicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313014517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Protection+from+HIV%3A+Targeted+Intervention+Strategies+%28X8%29&rft.atitle=Determinants+of+Poor+Immunogenicity+of+Alternative+Adenoviruses&rft.au=Johnson%2C+Matthew&rft.aulast=Johnson&rft.aufirst=Matthew&rft.date=2011-03-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Protection+from+HIV%3A+Targeted+Intervention+Strategies+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1110&CFID=359976&CFTOKEN=23323681 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Efficacy of HIV Vaccine Candidate in Macaques Dependent on the Dose of SIVmac251 Challenge Exposure T2 - 2011 Keystone Symposia on Protection from HIV: Targeted Intervention Strategies (X8) AN - 1312981688; 6064968 JF - 2011 Keystone Symposia on Protection from HIV: Targeted Intervention Strategies (X8) AU - Vaccari, Monica Y1 - 2011/03/20/ PY - 2011 DA - 2011 Mar 20 KW - Human immunodeficiency virus KW - vaccines KW - Vaccines KW - Disease control KW - Macaca UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312981688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Protection+from+HIV%3A+Targeted+Intervention+Strategies+%28X8%29&rft.atitle=Efficacy+of+HIV+Vaccine+Candidate+in+Macaques+Dependent+on+the+Dose+of+SIVmac251+Challenge+Exposure&rft.au=Vaccari%2C+Monica&rft.aulast=Vaccari&rft.aufirst=Monica&rft.date=2011-03-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Protection+from+HIV%3A+Targeted+Intervention+Strategies+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1110&CFID=359976&CFTOKEN=23323681 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Infection of Cervical Tissue Explants with Transmitted/Founder HIV-1 Viruses T2 - 2011 Keystone Symposia on Protection from HIV: Targeted Intervention Strategies (X8) AN - 1312930384; 6064973 JF - 2011 Keystone Symposia on Protection from HIV: Targeted Intervention Strategies (X8) AU - Grivel, Jean-Charles Y1 - 2011/03/20/ PY - 2011 DA - 2011 Mar 20 KW - Infection KW - Viruses KW - Disease transmission KW - Explants KW - Human immunodeficiency virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312930384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Protection+from+HIV%3A+Targeted+Intervention+Strategies+%28X8%29&rft.atitle=Infection+of+Cervical+Tissue+Explants+with+Transmitted%2FFounder+HIV-1+Viruses&rft.au=Grivel%2C+Jean-Charles&rft.aulast=Grivel&rft.aufirst=Jean-Charles&rft.date=2011-03-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Protection+from+HIV%3A+Targeted+Intervention+Strategies+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1110&CFID=359976&CFTOKEN=23323681 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Isolation and Characterization of Broadly Neutralizing Monoclonal Antibodies to HIV-1 T2 - 2011 Keystone Symposia on Protection from HIV: Targeted Intervention Strategies (X8) AN - 1312917169; 6064981 JF - 2011 Keystone Symposia on Protection from HIV: Targeted Intervention Strategies (X8) AU - Mascola, John Y1 - 2011/03/20/ PY - 2011 DA - 2011 Mar 20 KW - Monoclonal antibodies KW - Human immunodeficiency virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312917169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Protection+from+HIV%3A+Targeted+Intervention+Strategies+%28X8%29&rft.atitle=Isolation+and+Characterization+of+Broadly+Neutralizing+Monoclonal+Antibodies+to+HIV-1&rft.au=Mascola%2C+John&rft.aulast=Mascola&rft.aufirst=John&rft.date=2011-03-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Protection+from+HIV%3A+Targeted+Intervention+Strategies+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1110&CFID=359976&CFTOKEN=23323681 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Prospects for Generating VRC01-like Antibodies Revealed by Crystal Structures and 454 Pyrosequencing T2 - 2011 Keystone Symposia on Protection from HIV: Targeted Intervention Strategies (X8) AN - 1312917124; 6064980 JF - 2011 Keystone Symposia on Protection from HIV: Targeted Intervention Strategies (X8) AU - Kwong, Peter Y1 - 2011/03/20/ PY - 2011 DA - 2011 Mar 20 KW - Antibodies KW - Crystal structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312917124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Protection+from+HIV%3A+Targeted+Intervention+Strategies+%28X8%29&rft.atitle=Prospects+for+Generating+VRC01-like+Antibodies+Revealed+by+Crystal+Structures+and+454+Pyrosequencing&rft.au=Kwong%2C+Peter&rft.aulast=Kwong&rft.aufirst=Peter&rft.date=2011-03-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Protection+from+HIV%3A+Targeted+Intervention+Strategies+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1110&CFID=359976&CFTOKEN=23323681 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - I-131 Dose Response for Incident Thyroid Cancers in Ukraine Related to the Chornobyl Accident AN - 920792394; 16210162 AB - Background: Current knowledge about Chornobyl-related thyroid cancer risks comes from ecological studies based on grouped doses, case-control studies, and studies of prevalent cancers. Objective: To address this limitation, we evaluated the dose-response relationship for incident thyroid cancers using measurement-based individual iodine-131 (I-131) thyroid dose estimates in a prospective analytic cohort study. Methods: The cohort consists of individuals & 18 years of age on 26 April 1986 who resided in three contaminated oblasts (states) of Ukraine and underwent up to four thyroid screening examinations between 1998 and 2007 (n = 12,514). Thyroid doses of I-131 were estimated based on individual radioactivity measurements taken within 2 months after the accident, environmental transport models, and interview data. Excess radiation risks were estimated using Poisson regression models. Results: Sixty-five incident thyroid cancers were diagnosed during the second through fourth screenings and 73,004 person-years (PY) of observation. The dose-response relationship was consistent with linearity on relative and absolute scales, although the excess relative risk (ERR) model described data better than did the excess absolute risk (EAR) model. The ERR per gray was 1.91 [95% confidence interval (CI), 0.43-6.34], and the EAR per 104 PY/Gy was 2.21 (95% CI, 0.04-5.78). The ERR per gray varied significantly by oblast of residence but not by time since exposure, use of iodine prophylaxis, iodine status, sex, age, or tumor size. Conclusions: I-131-related thyroid cancer risks persisted for two decades after exposure, with no evidence of decrease during the observation period. The radiation risks, although smaller, are compatible with those of retrospective and ecological post-Chornobyl studies. JF - Environmental Health Perspectives AU - Brenner, Alina V AU - Tronko, Mykola D AU - Hatch, Maureen AU - Bogdanova, Tetyana I AU - Oliynik, Valery A AU - Lubin, Jay H AU - Zablotska, Lydia B AU - Tereschenko, Valery P AU - McConnell, Robert J AU - Zamotaeva, Galina A AU - O'Kane, Patrick AU - Bouville, Andre C AU - Chaykovskaya, Ludmila V AU - Greenebaum, Ellen AU - Paster, Ihor P AU - Shpak, Victor M AU - Ron, Elaine AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2011/03/17/ PY - 2011 DA - 2011 Mar 17 SP - 933 EP - 939 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 119 IS - 7 SN - 0091-6765, 0091-6765 KW - Pollution Abstracts; Risk Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - Chernobyl nuclear accident KW - Chornobyl, Ukraine, 1986 KW - dose-response relationship KW - incidence, thyroid neoplasms/epidemiology KW - iodine KW - radioactive KW - radiation KW - Accidents KW - Age KW - Dose-response effects KW - Ukraine KW - Thyroid KW - Iodine KW - tumors KW - Radioactivity KW - Tumors KW - Cancer KW - H 2000:Transportation KW - R2 23050:Environment KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920792394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=I-131+Dose+Response+for+Incident+Thyroid+Cancers+in+Ukraine+Related+to+the+Chornobyl+Accident&rft.au=Brenner%2C+Alina+V%3BTronko%2C+Mykola+D%3BHatch%2C+Maureen%3BBogdanova%2C+Tetyana+I%3BOliynik%2C+Valery+A%3BLubin%2C+Jay+H%3BZablotska%2C+Lydia+B%3BTereschenko%2C+Valery+P%3BMcConnell%2C+Robert+J%3BZamotaeva%2C+Galina+A%3BO%27Kane%2C+Patrick%3BBouville%2C+Andre+C%3BChaykovskaya%2C+Ludmila+V%3BGreenebaum%2C+Ellen%3BPaster%2C+Ihor+P%3BShpak%2C+Victor+M%3BRon%2C+Elaine&rft.aulast=Brenner&rft.aufirst=Alina&rft.date=2011-03-17&rft.volume=119&rft.issue=7&rft.spage=933&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002674 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Age; Accidents; Dose-response effects; Thyroid; Iodine; tumors; Tumors; Radioactivity; Cancer; Ukraine DO - http://dx.doi.org/10.1289/ehp.1002674 ER - TY - JOUR T1 - Assessment of human papillomavirus in lung tumor tissue. AN - 857481693; 21293027 AB - Lung cancer kills more than 1 million people worldwide each year. Whereas several human papillomavirus (HPV)-associated cancers have been identified, the role of HPV in lung carcinogenesis remains controversial. We selected 450 lung cancer patients from an Italian population-based case-control study, the Environment and Genetics in Lung Cancer Etiology. These patients were selected from those with an adequate number of unstained tissue sections and included all those who had never smoked and a random sample of the remaining patients. We used real-time polymerase chain reaction (PCR) to test specimens from these patients for HPV DNA, specifically for E6 gene sequences from HPV16 and E7 gene sequences from HPV18. We also tested a subset of 92 specimens from all never-smokers and a random selection of smokers for additional HPV types by a PCR-based test for at least 54 mucosal HPV genotypes. DNA was extracted from ethanol- or formalin-fixed paraffin-embedded tumor tissue under strict PCR clean conditions. The prevalence of HPV in tumor tissue was investigated. Specimens from 399 of 450 patients had adequate DNA for analysis. Most patients were current (220 patients or 48.9%) smokers, and 92 patients (20.4%) were women. When HPV16 and HPV18 type-specific primers were used, two specimens were positive for HPV16 at low copy number but were negative on additional type-specific HPV16 testing. Neither these specimens nor the others examined for a broad range of HPV types were positive for any HPV type. When DNA contamination was avoided and state-of-the-art highly sensitive HPV DNA detection assays were used, we found no evidence that HPV was associated with lung cancer in a representative Western population. Our results provide the strongest evidence to date to rule out a role for HPV in lung carcinogenesis in Western populations. JF - Journal of the National Cancer Institute AU - Koshiol, Jill AU - Rotunno, Melissa AU - Gillison, Maura L AU - Van Doorn, Leen-Jan AU - Chaturvedi, Anil K AU - Tarantini, Letizia AU - Song, Hebin AU - Quint, Wim G V AU - Struijk, Linda AU - Goldstein, Alisa M AU - Hildesheim, Allan AU - Taylor, Philip R AU - Wacholder, Sholom AU - Bertazzi, Pietro Alberto AU - Landi, Maria Teresa AU - Caporaso, Neil E AD - Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7248, USA. koshiolj@mail.nih.gov Y1 - 2011/03/16/ PY - 2011 DA - 2011 Mar 16 SP - 501 EP - 507 VL - 103 IS - 6 KW - DNA, Viral KW - 0 KW - DNA-Binding Proteins KW - E6 protein, Human papillomavirus type 16 KW - E7 protein, Human papillomavirus type 18 KW - Oncogene Proteins, Viral KW - Repressor Proteins KW - Index Medicus KW - Neoplasm Staging KW - Humans KW - DNA-Binding Proteins -- genetics KW - Smoking -- adverse effects KW - Aged KW - Repressor Proteins -- genetics KW - Polymerase Chain Reaction KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Oncogene Proteins, Viral -- genetics KW - DNA, Viral -- isolation & purification KW - Middle Aged KW - Italy -- epidemiology KW - Time Factors KW - Female KW - Male KW - Tumor Virus Infections -- virology KW - Papillomavirus Infections -- diagnosis KW - Alphapapillomavirus -- isolation & purification KW - Papillomavirus Infections -- complications KW - Tumor Virus Infections -- diagnosis KW - Tumor Virus Infections -- epidemiology KW - Papillomavirus Infections -- virology KW - Alphapapillomavirus -- genetics KW - Papillomavirus Infections -- epidemiology KW - Lung Neoplasms -- etiology KW - Lung Neoplasms -- epidemiology KW - Lung Neoplasms -- virology KW - Lung Neoplasms -- pathology KW - Tumor Virus Infections -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/857481693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Assessment+of+human+papillomavirus+in+lung+tumor+tissue.&rft.au=Koshiol%2C+Jill%3BRotunno%2C+Melissa%3BGillison%2C+Maura+L%3BVan+Doorn%2C+Leen-Jan%3BChaturvedi%2C+Anil+K%3BTarantini%2C+Letizia%3BSong%2C+Hebin%3BQuint%2C+Wim+G+V%3BStruijk%2C+Linda%3BGoldstein%2C+Alisa+M%3BHildesheim%2C+Allan%3BTaylor%2C+Philip+R%3BWacholder%2C+Sholom%3BBertazzi%2C+Pietro+Alberto%3BLandi%2C+Maria+Teresa%3BCaporaso%2C+Neil+E&rft.aulast=Koshiol&rft.aufirst=Jill&rft.date=2011-03-16&rft.volume=103&rft.issue=6&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/10.1093%2Fjnci%2Fdjr003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-10 N1 - Date created - 2011-03-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Pathol. 2000 Sep;53(9):676-84 [11041057] Cancer Epidemiol Biomarkers Prev. 2010 Aug;19(8):1889-92 [20696658] Cancer Res. 2001 Apr 1;61(7):2799-803 [11306446] Histopathology. 2001 Apr;38(4):355-67 [11318901] Clin Otolaryngol Allied Sci. 2002 Aug;27(4):237-43 [12169123] Oncogene. 2002 Oct 21;21(48):7307-25 [12379875] J Natl Cancer Inst Monogr. 2003;(31):57-65 [12807947] J Virol Methods. 2003 Sep;112(1-2):23-33 [12951209] Cancer Res. 1991 Oct 1;51(19):5370-7 [1717149] Laryngoscope. 1992 Jan;102(1):9-13 [1309932] Am J Pathol. 1998 Dec;153(6):1731-9 [9846964] J Clin Microbiol. 1999 Aug;37(8):2508-17 [10405393] J Pathol. 1999 Sep;189(1):12-9 [10451482] Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):467-75 [15734974] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Mod Pathol. 2005 Dec;18(12):1606-9 [16056245] Vaccine. 2006 Aug 31;24 Suppl 3:S3/1-10 [16949995] J Clin Microbiol. 2006 Sep;44(9):3292-8 [16954263] AIDS. 2007 Jan 11;21(2):207-13 [17197812] Int J Cancer. 2007 Feb 15;120(4):885-91 [17131323] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] Dis Markers. 2007;23(4):213-27 [17627057] Head Neck. 2007 Aug;29(8):779-92 [17230556] Anticancer Res. 2007 Jul-Aug;27(4C):2697-704 [17695435] Nat Rev Cancer. 2007 Oct;7(10):778-90 [17882278] BMC Public Health. 2008;8:203 [18538025] Oncol Rep. 2008 Aug;20(2):333-9 [18636194] Cancer. 2008 Nov 15;113(10 Suppl):3036-46 [18980286] J Clin Oncol. 2009 Feb 20;27(6):967-73 [19114696] Curr Opin HIV AIDS. 2009 Jan;4(1):68-73 [19339941] Carcinogenesis. 2009 Oct;30(10):1722-8 [19620233] Eur J Clin Microbiol Infect Dis. 2009 Nov;28(11):1285-9 [19603206] Int J Cancer. 2010 Jan 1;126(1):224-31 [19585576] Lancet Oncol. 2010 Aug;11(8):781-9 [20451455] J Virol Methods. 2001 Feb;91(2):109-17 [11164492] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jnci/djr003 ER - TY - CPAPER T1 - Update on the NIH's Genetic Testing Registry (GTR) T2 - 2011 Annual Clinical Genetics Meeting of the American College of Medical Genetics (ACMG 2011) AN - 1312974068; 6083593 JF - 2011 Annual Clinical Genetics Meeting of the American College of Medical Genetics (ACMG 2011) AU - Kattman, Brandi Y1 - 2011/03/16/ PY - 2011 DA - 2011 Mar 16 KW - genetic screening KW - Genetic screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312974068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Clinical+Genetics+Meeting+of+the+American+College+of+Medical+Genetics+%28ACMG+2011%29&rft.atitle=Update+on+the+NIH%27s+Genetic+Testing+Registry+%28GTR%29&rft.au=Kattman%2C+Brandi&rft.aulast=Kattman&rft.aufirst=Brandi&rft.date=2011-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Clinical+Genetics+Meeting+of+the+American+College+of+Medical+Genetics+%28ACMG+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.acmgmeeting.net/acmg2011/CUSTOM/images/client/2011/2011%20ACMG%20Annual%20Meeting%20-%20Program%20Guide.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Policy, Oversight and Regulatory Frameworks T2 - 2011 Annual Clinical Genetics Meeting of the American College of Medical Genetics (ACMG 2011) AN - 1312944480; 6083714 JF - 2011 Annual Clinical Genetics Meeting of the American College of Medical Genetics (ACMG 2011) AU - Clauser, Steven Y1 - 2011/03/16/ PY - 2011 DA - 2011 Mar 16 KW - Policies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312944480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Clinical+Genetics+Meeting+of+the+American+College+of+Medical+Genetics+%28ACMG+2011%29&rft.atitle=Policy%2C+Oversight+and+Regulatory+Frameworks&rft.au=Clauser%2C+Steven&rft.aulast=Clauser&rft.aufirst=Steven&rft.date=2011-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Clinical+Genetics+Meeting+of+the+American+College+of+Medical+Genetics+%28ACMG+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.acmgmeeting.net/acmg2011/CUSTOM/images/client/2011/2011%20ACMG%20Annual%20Meeting%20-%20Program%20Guide.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Deuteration of Escherichia coli Enzyme I[super]Ntr alters its stability AN - 907158535; 14418404 AB - Enzyme I[super]Ntr is the first protein in the nitrogen phosphotransferase pathway. Using an array of biochemical and biophysical tools, we characterized the protein, compared its properties to that of EI of the carbohydrate PTS and, in addition, examined the effect of substitution of all nonexchangeable protons by deuterium (perdeuteration) on the properties of EI[super]Ntr. Notably, we find that the catalytic function (autophosphorylation and phosphotransfer to NPr) remains unperturbed while its stability is modulated by deuteration. In particular, the deuterated form exhibits a reduction of approximately 4 [deg]C in thermal stability, enhanced oligomerization propensity, as well as increased sensitivity to proteolysis in vitro. We investigated tertiary, secondary, and local structural changes, both in the absence and presence of PEP, using near- and far-UV circular dichroism and Trp fluorescence spectroscopy. Our data demonstrate that the aromatic residues are particularly sensitive probes for detecting effects of deuteration with an enhanced quantum yield upon PEP binding and apparent decreases in tertiary contacts for Tyr and Trp side chains. Trp mutagenesis studies showed that the region around Trp522 responds to binding of both PEP and NPr. The significance of these results in the context of structural analysis of EI[super]Ntr are evaluated. JF - Archives of Biochemistry and Biophysics AU - Piszczek, Grzegorz AU - Lee, Jennifer C AU - Tjandra, Nico AU - Lee, Chang-Ro AU - Seok, Yeong-Jae AU - Levine, Rodney L AU - Peterkofsky, Alan AD - The National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA, peterkofsky@nih.gov Y1 - 2011/03/15/ PY - 2011 DA - 2011 Mar 15 SP - 332 EP - 342 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 507 IS - 2 SN - 0003-9861, 0003-9861 KW - Microbiology Abstracts B: Bacteriology KW - Proteolysis KW - Data processing KW - Protons KW - Oligomerization KW - Probes KW - Enzymes KW - phosphotransferase KW - Mutagenesis KW - fluorescence spectroscopy KW - C.D. KW - Escherichia coli KW - Carbohydrates KW - Thermal stability KW - Aromatics KW - Nitrogen KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907158535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Biochemistry+and+Biophysics&rft.atitle=Deuteration+of+Escherichia+coli+Enzyme+I%5Bsuper%5DNtr+alters+its+stability&rft.au=Piszczek%2C+Grzegorz%3BLee%2C+Jennifer+C%3BTjandra%2C+Nico%3BLee%2C+Chang-Ro%3BSeok%2C+Yeong-Jae%3BLevine%2C+Rodney+L%3BPeterkofsky%2C+Alan&rft.aulast=Piszczek&rft.aufirst=Grzegorz&rft.date=2011-03-15&rft.volume=507&rft.issue=2&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=Archives+of+Biochemistry+and+Biophysics&rft.issn=00039861&rft_id=info:doi/10.1016%2Fj.abb.2010.12.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Proteolysis; Data processing; Protons; Oligomerization; Probes; Enzymes; phosphotransferase; Mutagenesis; fluorescence spectroscopy; C.D.; Thermal stability; Carbohydrates; Aromatics; Nitrogen; Escherichia coli DO - http://dx.doi.org/10.1016/j.abb.2010.12.022 ER - TY - JOUR T1 - Spiral Architecture of the Nucleoid in Bdellovibrio bacteriovorus AN - 907157221; 14405232 AB - We present a cryo-electron tomographic analysis of the three-dimensional architecture of a strain of the Gram-negative bacterium Bdellovibrio bacteriovorus in which endogenous MreB2 was replaced with monomeric teal fluorescent protein (mTFP)-labeled MreB2. In contrast to wild-type Bdellovibrio cells that predominantly displayed a compact nucleoid region, cells expressing mTFP-labeled MreB2 displayed a twisted spiral organization of the nucleoid. The more open structure of the MreB2-mTFP nucleoids enabled clear in situ visualization of ribosomes decorating the periphery of the nucleoid. Ribosomes also bordered the edges of more compact nucleoids from both wild-type cells and mutant cells. Surprisingly, MreB2-mTFP localized to the interface between the spiral nucleoid and the cytoplasm, suggesting an intimate connection between nucleoid architecture and MreB arrangement. Further, in contrast to wild-type cells, where a single tight chemoreceptor cluster localizes close to the single polar flagellum, MreB2-mTFP cells often displayed extended chemoreceptor arrays present at one or both poles and displayed multiple or inaccurately positioned flagella. Our findings provide direct structural evidence for spiral organization of the bacterial nucleoid and suggest a possible role for MreB in regulation of nucleoid architecture and localization of the chemotaxis apparatus. JF - Journal of Bacteriology AU - Butan, Carmen AU - Hartnell, Lisa M AU - Fenton, Andrew K AU - Bliss, Donald AU - Sockett, RElizabeth AU - Subramaniam, Sriram AU - Milne, Jacqueline LS AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2011/03/15/ PY - 2011 DA - 2011 Mar 15 SP - 1341 EP - 1350 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 193 IS - 6 SN - 0021-9193, 0021-9193 KW - Chemoreception Abstracts; Microbiology Abstracts B: Bacteriology KW - Bdellovibrio KW - Chemoreceptors KW - Cytoplasm KW - Bdellovibrio bacteriovorus KW - Nucleoids KW - Ribosomes KW - Chemotaxis KW - Flagella KW - R 18003:Chemotaxis KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907157221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Spiral+Architecture+of+the+Nucleoid+in+Bdellovibrio+bacteriovorus&rft.au=Butan%2C+Carmen%3BHartnell%2C+Lisa+M%3BFenton%2C+Andrew+K%3BBliss%2C+Donald%3BSockett%2C+RElizabeth%3BSubramaniam%2C+Sriram%3BMilne%2C+Jacqueline+LS&rft.aulast=Butan&rft.aufirst=Carmen&rft.date=2011-03-15&rft.volume=193&rft.issue=6&rft.spage=1341&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Chemoreceptors; Cytoplasm; Ribosomes; Nucleoids; Chemotaxis; Flagella; Bdellovibrio; Bdellovibrio bacteriovorus ER - TY - JOUR T1 - Bambino: a variant detector and alignment viewer for next-generation sequencing data in the SAM/BAM format AN - 869810139; 14541610 AB - Summary: Bambino is a variant detector and graphical alignment viewer for next-generation sequencing data in the SAM/BAM format, which is capable of pooling data from multiple source files. The variant detector takes advantage of SAM-specific annotations, and produces detailed output suitable for genotyping and identification of somatic mutations. The assembly viewer can display reads in the context of either a user-provided or automatically generated reference sequence, retrieve genome annotation features from a UCSC genome annotation database, display histograms of non-reference allele frequencies, and predict protein-coding changes caused by SNPs. JF - Bioinformatics AU - Edmonson, Michael N AU - Zhang, Jinghui AU - Yan, Chunhua AU - Finney, Richard P AU - Meerzaman, Daoud M AU - Buetow, Kenneth H AD - super(1)Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, super(2)Department of Computational Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 and super(3)Center for Bioinformatics and Information Technology, National Cancer Institute, Rockville, MD 20852, USA Y1 - 2011/03/15/ PY - 2011 DA - 2011 Mar 15 SP - 865 EP - 866 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 27 IS - 6 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Computer programs KW - Databases KW - Data processing KW - Genotyping KW - Nucleotide sequence KW - Computer graphics KW - Gene frequency KW - Bioinformatics KW - Mutation KW - Internet KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869810139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Bambino%3A+a+variant+detector+and+alignment+viewer+for+next-generation+sequencing+data+in+the+SAM%2FBAM+format&rft.au=Edmonson%2C+Michael+N%3BZhang%2C+Jinghui%3BYan%2C+Chunhua%3BFinney%2C+Richard+P%3BMeerzaman%2C+Daoud+M%3BBuetow%2C+Kenneth+H&rft.aulast=Edmonson&rft.aufirst=Michael&rft.date=2011-03-15&rft.volume=27&rft.issue=6&rft.spage=865&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtr032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Genomes; Databases; Computer programs; Data processing; Nucleotide sequence; Genotyping; Computer graphics; Gene frequency; Bioinformatics; Mutation; Internet DO - http://dx.doi.org/10.1093/bioinformatics/btr032 ER - TY - JOUR T1 - Antibody-mediated neutralization of flaviviruses: A reductionist view AN - 860379281; 14439361 AB - Flaviviruses are a group of ~ 70 small RNA viruses responsible for significant morbidity and mortality across the globe. Efforts to develop effective vaccines for several clinically important flaviviruses are underway. Antibodies are a significant component of the host's protective response against flavivirus infection with the potential to contribute to immunity via several distinct mechanisms, including an ability to directly neutralize virus infection. Conversely, virus-reactive antibodies have been implicated in the increased risk of severe clinical manifestations following secondary dengue virus infection. In this review, we will discuss recent progress toward understanding the molecular basis of antibody-mediated neutralization of flaviviruses. Neutralization requires engagement of the virion with a stoichiometry that exceeds a required threshold. From this perspective, we will discuss viral and host factors that impact the number of antibody molecules bound to the virus particle and significantly modulate the potency of neutralizing antibodies. JF - Virology AU - Dowd, Kimberly A AU - Pierson, Theodore C AD - Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, piersontc@mail.nih.gov Y1 - 2011/03/15/ PY - 2011 DA - 2011 Mar 15 SP - 306 EP - 315 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 411 IS - 2 SN - 0042-6822, 0042-6822 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Virology & AIDS Abstracts KW - Flavivirus KW - Antibody-mediated neutralization KW - Antibody-dependent enhancement of infection KW - West Nile virus KW - Dengue virus KW - Complement KW - Virions KW - Virology KW - Mortality KW - Viruses KW - Disease control KW - RNA viruses KW - Immunity KW - Infection KW - Morbidity KW - Antibodies KW - Viral diseases KW - Vaccines KW - Mortality causes KW - V 22350:Immunology KW - Q1 08423:Behaviour KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860379281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Antibody-mediated+neutralization+of+flaviviruses%3A+A+reductionist+view&rft.au=Dowd%2C+Kimberly+A%3BPierson%2C+Theodore+C&rft.aulast=Dowd&rft.aufirst=Kimberly&rft.date=2011-03-15&rft.volume=411&rft.issue=2&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2010.12.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Virology; Antibodies; Viral diseases; Viruses; Disease control; Vaccines; Immunity; Mortality causes; Virions; Mortality; RNA viruses; Infection; Morbidity; Dengue virus; Flavivirus DO - http://dx.doi.org/10.1016/j.virol.2010.12.020 ER - TY - JOUR T1 - CHIP and gp78-mediated ubiquitination of CYP3A4: Implications for the pharmacology of anticancer agents. AN - 857482391; 21270532 AB - The autocrine motility factor receptor or glycoprotein-78 (gp78) and C-terminus of Hsp70-interacting protein (CHIP) are E3-ligases required for ubiquitination of cytochrome P450s of the 3A subfamily (CYP3A) in endoplasmic reticulum-associated degradation (ERAD). The CYP isozyme 3A4 (CYP3A4) is responsible for the metabolism of the majority of xenobiotics including anticancer agents. Much variability in clinical response to chemotherapy is observed and it has been suggested that variability in CYP3A4 expression could be a factor. The study reviewed in this journal club comments on the importance of further characterizing gp78 and CHIP as relevant proteins in ERAD of CYP3A4. This study demonstrated how both gp78 and CHIP play direct roles in reducing CYP3A4 protein content as well as CYP3A4 ubiquitination. Interestingly, when gp78 and CHIP were knocked down by siRNAs directed towards each protein, the stabilized CYP3A4 remained functional. This has implications for drug-drug interactions for agents metabolized by CYP3A4, which can influence drug exposure levels. This is relevant because most anticancer agents have very narrow therapeutic windows, thus even slight changes in CYP3A4 levels could alter the exposure of that drug and result in either insufficient efficacy or toxicity. Future studies must explore genetic variability in the ERAD pathway and identify new factors that influence CYP3A ERAD in order to better characterize how CYP3A variability affects anticancer drug pharmacology. JF - Cancer biology & therapy AU - Peer, Cody J AU - Sissung, Tristan M AU - Figg, William D AD - National Cancer Institute, Bethesda, MD, USA. Y1 - 2011/03/15/ PY - 2011 DA - 2011 Mar 15 SP - 549 EP - 551 VL - 11 IS - 6 KW - Anticarcinogenic Agents KW - 0 KW - RNA, Small Interfering KW - Receptors, Cytokine KW - Ubiquitin KW - CYP3A4 protein, human KW - EC 1.14.13.67 KW - Cytochrome P-450 CYP3A KW - EC 1.14.14.1 KW - AMFR protein, human KW - EC 2.3.2.27 KW - Receptors, Autocrine Motility Factor KW - STUB1 protein, human KW - Ubiquitin-Protein Ligases KW - Index Medicus KW - Rats KW - Neoplasms -- drug therapy KW - Animals KW - Gene Knockdown Techniques KW - Ubiquitin -- metabolism KW - Ubiquitin -- genetics KW - Humans KW - RNA, Small Interfering -- genetics KW - Neoplasms -- metabolism KW - Gene Expression Regulation -- genetics KW - Anticarcinogenic Agents -- therapeutic use KW - Cytochrome P-450 CYP3A -- metabolism KW - Ubiquitin-Protein Ligases -- genetics KW - Receptors, Cytokine -- genetics KW - Anticarcinogenic Agents -- pharmacology KW - Ubiquitination KW - Anticarcinogenic Agents -- chemistry KW - Ubiquitin-Protein Ligases -- metabolism KW - Cytochrome P-450 CYP3A -- genetics KW - Receptors, Cytokine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/857482391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=CHIP+and+gp78-mediated+ubiquitination+of+CYP3A4%3A+Implications+for+the+pharmacology+of+anticancer+agents.&rft.au=Peer%2C+Cody+J%3BSissung%2C+Tristan+M%3BFigg%2C+William+D&rft.aulast=Peer&rft.aufirst=Cody&rft.date=2011-03-15&rft.volume=11&rft.issue=6&rft.spage=549&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=1555-8576&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-05 N1 - Date created - 2011-03-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Cancer Res. 2000 Apr;6(4):1255-8 [10778948] J Pharmacol Exp Ther. 2010 Mar;332(3):1088-99 [19934400] Arch Biochem Biophys. 2001 Sep 1;393(1):106-16 [11516167] Biochemistry. 2001 Sep 25;40(38):11318-26 [11560479] Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14422-7 [11724934] J Pediatr Hematol Oncol. 2002 Feb;24(2):130-3 [11990699] Clin Cancer Res. 2002 May;8(5):935-42 [12006504] Drug Metab Rev. 2003 May-Aug;35(2-3):107-43 [12959413] Arch Biochem Biophys. 1987 Nov 1;258(2):436-51 [3674884] Arch Biochem Biophys. 1992 Sep;297(2):228-38 [1497342] J Pharmacol Exp Ther. 1994 Jul;270(1):414-23 [8035341] Annu Rev Genet. 1996;30:405-39 [8982460] Pharmacol Ther. 1997;74(1):39-54 [9336015] Biochemistry. 1998 Dec 15;37(50):17448-57 [9860860] Arch Biochem Biophys. 1999 May 1;365(1):31-44 [10222036] Arch Biochem Biophys. 1999 May 1;365(1):45-53 [10222037] Clin Pharmacokinet. 2005;44(4):349-66 [15828850] Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):341-6 [16407162] Mol Pharmacol. 2006 Jun;69(6):1897-904 [16556771] Nat Rev Cancer. 2006 Jul;6(7):546-58 [16794637] Breast Cancer Res Treat. 2007 Jan;101(1):113-21 [17115111] Expert Opin Drug Metab Toxicol. 2007 Feb;3(1):33-49 [17269893] Biochemistry. 2007 Jul 3;46(26):7793-803 [17550236] J Pharmacol Exp Ther. 2007 Dec;323(3):979-89 [17761498] Nat Med. 2007 Dec;13(12):1504-9 [18037895] Arch Biochem Biophys. 2009 Mar 1;483(1):66-74 [19103148] J Biol Chem. 2009 Feb 27;284(9):5671-84 [19095658] Pharmacogenetics. 2000 Jul;10(5):373-88 [10898107] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acute and late toxicity in a randomized trial of conventional versus hypofractionated three-dimensional conformal radiotherapy for prostate cancer. AN - 854379443; 20447774 AB - To compare the toxicity between hypofractionation vs. conventional fractionation schedules in patients with high-risk prostate cancer. Between January 2003 and December 2007, 168 patients were randomized to receive either hypofractionated (62 Gy in 20 fractions within 5 weeks, 4 fractions/wk) or conventionally fractionated (80 Gy in 40 fractions within 8 weeks) three-dimensional conformal radiotherapy to the prostate and seminal vesicles. All patients had undergone a 9-month course of total androgen deprivation, with radiotherapy starting 2 months after initiation of the total androgen deprivation. The median follow-up was 32 and 35 months in the hypofractionation and conventional fractionation arms, respectively. For the patients developing acute toxicity, no difference between the two fractionation groups was found in either severity or duration of gastrointestinal or genitourinary toxicity. Also, no difference was found in the incidence and severity of late gastrointestinal and genitourinary toxicity between the two treatment schedules, with a 3-year rate of Grade 2 or greater toxicity of 17% and 16% for the hypofractionation arm and 14% and 11% for the conventional fractionation arm, respectively. A statistically significant correlation between acute and late gastrointestinal toxicity was found only in the conventional fractionation group. Our findings suggest that the hypofractionation regimen used in our study is safe, with only a slight, nonsignificant increase in tolerable and temporary acute toxicity compared with the conventional fractionation schedule. The severity and frequency of late complications was equivalent between the two treatment groups. Copyright © 2011 Elsevier Inc. All rights reserved. JF - International journal of radiation oncology, biology, physics AU - Arcangeli, Giorgio AU - Fowler, Jack AU - Gomellini, Sara AU - Arcangeli, Stefano AU - Saracino, Biancamaria AU - Petrongari, Maria Grazia AU - Benassi, Marcello AU - Strigari, Lidia AD - Department of Radiation Oncology, Regina Elena National Cancer Institute, Rome, Italy. arcangeli.gio@gmail.com Y1 - 2011/03/15/ PY - 2011 DA - 2011 Mar 15 SP - 1013 EP - 1021 VL - 79 IS - 4 KW - Index Medicus KW - Acute Disease KW - Dose Fractionation KW - Urogenital System -- radiation effects KW - Humans KW - Seminal Vesicles -- radiation effects KW - Aged KW - Gastrointestinal Tract -- radiation effects KW - Aged, 80 and over KW - Prostate -- radiation effects KW - Radiotherapy Dosage KW - Follow-Up Studies KW - Middle Aged KW - Time Factors KW - Male KW - Radiotherapy, Conformal -- methods KW - Prostatic Neoplasms -- drug therapy KW - Prostatic Neoplasms -- radiotherapy KW - Radiotherapy, Conformal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/854379443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Acute+and+late+toxicity+in+a+randomized+trial+of+conventional+versus+hypofractionated+three-dimensional+conformal+radiotherapy+for+prostate+cancer.&rft.au=Arcangeli%2C+Giorgio%3BFowler%2C+Jack%3BGomellini%2C+Sara%3BArcangeli%2C+Stefano%3BSaracino%2C+Biancamaria%3BPetrongari%2C+Maria+Grazia%3BBenassi%2C+Marcello%3BStrigari%2C+Lidia&rft.aulast=Arcangeli&rft.aufirst=Giorgio&rft.date=2011-03-15&rft.volume=79&rft.issue=4&rft.spage=1013&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=1879-355X&rft_id=info:doi/10.1016%2Fj.ijrobp.2009.12.045 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-04-15 N1 - Date created - 2011-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ijrobp.2009.12.045 ER - TY - CPAPER T1 - State of fungal genome resources at NCBI T2 - 26th Fungal Genetics Conference (GSA FGC 2011) AN - 1313012682; 6060890 JF - 26th Fungal Genetics Conference (GSA FGC 2011) AU - Robbertse, Barbara AU - Tatusova, Tatiana Y1 - 2011/03/15/ PY - 2011 DA - 2011 Mar 15 KW - Genomes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313012682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Fungal+Genetics+Conference+%28GSA+FGC+2011%29&rft.atitle=State+of+fungal+genome+resources+at+NCBI&rft.au=Robbertse%2C+Barbara%3BTatusova%2C+Tatiana&rft.aulast=Robbertse&rft.aufirst=Barbara&rft.date=2011-03-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Fungal+Genetics+Conference+%28GSA+FGC+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.fgsc.net/26thFGC/26FGCProgramAndAbstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - An evaluation of resampling methods for assessment of survival risk prediction in high-dimensional settings AN - 1017966498; 16691075 AB - Resampling techniques are often used to provide an initial assessment of accuracy for prognostic prediction models developed using high-dimensional genomic data with binary outcomes. Risk prediction is most important, however, in medical applications and frequently the outcome measure is a right-censored time-to-event variable such as survival. Although several methods have been developed for survival risk prediction with high-dimensional genomic data, there has been little evaluation of the use of resampling techniques for the assessment of such models. Using real and simulated datasets, we compared several resampling techniques for their ability to estimate the accuracy of risk prediction models. Our study showed that accuracy estimates for popular resampling methods, such as sample splitting and leave-one-out cross validation (Loo CV), have a higher mean square error than for other methods. Moreover, the large variability of the split-sample and Loo CV may make the point estimates of accuracy obtained using these methods unreliable and hence should be interpreted carefully. A k-fold cross-validation with k = 5 or 10 was seen to provide a good balance between bias and variability for a wide range of data settings and should be more widely adopted in practice. Published in 2010 by John Wiley & Sons, Ltd. JF - Statistics in Medicine AU - Subramanian, Jyothi AU - Simon, Richard Y1 - 2011/03/15/ PY - 2011 DA - 2011 Mar 15 SP - 642 EP - 653 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 30 IS - 6 SN - 1097-0258, 1097-0258 KW - Risk Abstracts KW - prediction models KW - survival KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017966498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistics+in+Medicine&rft.atitle=An+evaluation+of+resampling+methods+for+assessment+of+survival+risk+prediction+in+high-dimensional+settings&rft.au=Subramanian%2C+Jyothi%3BSimon%2C+Richard&rft.aulast=Subramanian&rft.aufirst=Jyothi&rft.date=2011-03-15&rft.volume=30&rft.issue=6&rft.spage=642&rft.isbn=&rft.btitle=&rft.title=Statistics+in+Medicine&rft.issn=10970258&rft_id=info:doi/10.1002%2Fsim.4106 L2 - http://onlinelibrary.wiley.com/doi/10.1002/sim.4106/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - prediction models; survival DO - http://dx.doi.org/10.1002/sim.4106 ER - TY - JOUR T1 - Autoimmune disease and subsequent risk of developing alimentary tract cancers among 4.5 million US male veterans AN - 1017962662; 16688840 AB - BACKGROUND: Autoimmunity is clearly linked with hematologic malignancies, but less is known about autoimmunity and alimentary tract cancer risk, despite the specific targeting of alimentary organs and tissues by several autoimmune diseases. The authors therefore conducted the first systematic evaluation of a broad range of specific autoimmune diseases and risk for subsequent alimentary tract cancer. METHODS: On the basis of 4,501,578 US male veterans, the authors identified 96,277 men who developed alimentary tract cancer during up to 26.2 years of follow-up. By using Poisson regression methods, the authors calculated relative risks (RRs) and 95% confidence intervals. RESULTS: A history of autoimmune disease with localized alimentary tract effects generally increased cancer risks in the organ(s) affected by the autoimmune disease, such as primary biliary cirrhosis and liver cancer (RR, 6.01; 95% confidence interval [CI], 4.76-7.57); pernicious anemia and stomach cancer (RR, 3.17; 95% CI, 2.47-4.07); and ulcerative colitis and small intestine, colon, and rectal cancers (RR, 2.53; 95% CI, 1.05-6.11; RR, 2.06; 95% CI, 1.70-2.48; and RR, 2.07; 95% CI, 1.62-2.64, respectively). In addition, a history of celiac disease, reactive arthritis (Reiter disease), and systemic sclerosis all were associated significantly with increased risk of esophageal cancer (RR, 1.86-2.86). Autoimmune diseases without localized alimentary tract effects generally were not associated with alimentary tract cancer risk, with the exception of decreased risk for multiple alimentary tract cancers associated with a history of multiple sclerosis. CONCLUSIONS: These findings support the importance of localized inflammation in alimentary tract carcinogenesis. Future research is needed to confirm the findings and improve understanding of underlying mechanisms by which autoimmune diseases contribute to alimentary tract carcinogenesis. Cancer 2011. Published 2010 by the American Cancer Society. JF - Cancer AU - Landgren, Annelie M AU - Landgren, Ola AU - Gridley, Gloria AU - Dores, Graca M AU - Linet, Martha S AU - Morton, Lindsay M AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, mortonli@mail.nih.gov Y1 - 2011/03/15/ PY - 2011 DA - 2011 Mar 15 SP - 1163 EP - 1171 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 117 IS - 6 SN - 1097-0142, 1097-0142 KW - Immunology Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Arthritis KW - USA KW - Digestive tract KW - Cancer KW - H 11000:Diseases/Injuries/Trauma KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017962662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Autoimmune+disease+and+subsequent+risk+of+developing+alimentary+tract+cancers+among+4.5+million+US+male+veterans&rft.au=Landgren%2C+Annelie+M%3BLandgren%2C+Ola%3BGridley%2C+Gloria%3BDores%2C+Graca+M%3BLinet%2C+Martha+S%3BMorton%2C+Lindsay+M&rft.aulast=Landgren&rft.aufirst=Annelie&rft.date=2011-03-15&rft.volume=117&rft.issue=6&rft.spage=1163&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=10970142&rft_id=info:doi/10.1002%2Fcncr.25524 L2 - http://onlinelibrary.wiley.com/doi/10.1002/cncr.25524/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2014-03-20 N1 - SubjectsTermNotLitGenreText - Digestive tract; Cancer; USA DO - http://dx.doi.org/10.1002/cncr.25524 ER - TY - JOUR T1 - Reproductive and hormonal factors and the risk of nonsmall cell lung cancer AN - 1017962271; 16690109 AB - Although exposure to estrogen may directly influence or modify the association between cigarette smoking and lung cancer risk, results from epidemiologic studies examining the association between reproductive and hormonal factors and risk of lung cancer among women have been inconsistent. Between 1998 and 2008, 430 women diagnosed with nonsmall cell lung cancer, 316 hospital controls and 295 population controls were recruited into the multi-center Maryland Lung Cancer Study. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) according to reproductive and hormonal exposures adjusting for age, smoking, passive smoking, education and household income. Results were similar for hospital and population based controls, so the control groups were combined. Reduced risks of lung cancer were observed among women with greater parity (>=5 vs. 1-2 births: OR = 0.50, 95% CI = 0.3,0.78, p-trend = 0.002) and later ages at last birth (>=30 vs. <25 years old: OR = 0.68, 95% CI = 0.4,0.98, p-trend = 0.04). After mutual adjustment parity, but not age at last birth, remained significantly inversely associated with risk (p-trend = 0.01). No associations were found for nonsmall cell lung cancer risk with age at menarche, age at first birth, menopausal status, oral contraceptive use or menopausal hormone use, including use of oral estrogens. Compatible with findings from recent epidemiologic studies, we observed a reduction in the risk of nonsmall cell lung cancer with increasing number of births. Other reproductive and hormonal exposures, including menopausal hormone therapy use, were not associated with risk. JF - International Journal of Cancer AU - Meinhold, Cari L AU - de Gonzalez, Amy Berrington AU - Bowman, Elise D AU - Brenner, Alina V AU - Jones, Raymond T AU - Lacey, James V, Jr AU - Loffredo, Christopher A AU - Perlmutter, Donna AU - Schonfeld, Sara J AU - Trivers, Glenwood E AU - Harris, Curtis C AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, meinholdc@mail.nih.gov Y1 - 2011/03/15/ PY - 2011 DA - 2011 Mar 15 SP - 1404 EP - 1413 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 128 IS - 6 SN - 1097-0215, 1097-0215 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Cancer KW - Cigarettes KW - Hormones KW - Hospitals KW - Lung cancer KW - Risk reduction KW - estrogens KW - parity KW - USA, Maryland KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017962271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Reproductive+and+hormonal+factors+and+the+risk+of+nonsmall+cell+lung+cancer&rft.au=Meinhold%2C+Cari+L%3Bde+Gonzalez%2C+Amy+Berrington%3BBowman%2C+Elise+D%3BBrenner%2C+Alina+V%3BJones%2C+Raymond+T%3BLacey%2C+James+V%2C+Jr%3BLoffredo%2C+Christopher+A%3BPerlmutter%2C+Donna%3BSchonfeld%2C+Sara+J%3BTrivers%2C+Glenwood+E%3BHarris%2C+Curtis+C&rft.aulast=Meinhold&rft.aufirst=Cari&rft.date=2011-03-15&rft.volume=128&rft.issue=6&rft.spage=1404&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=10970215&rft_id=info:doi/10.1002%2Fijc.25434 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ijc.25434/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - parity; Age; Cigarettes; Risk reduction; Hormones; Cancer; Hospitals; estrogens; Lung cancer; USA, Maryland DO - http://dx.doi.org/10.1002/ijc.25434 ER - TY - JOUR T1 - IQGAP1 in microbial pathogenesis: Targeting the actin cytoskeleton AN - 904467546; 14525609 AB - Microbial pathogens cause widespread morbidity and mortality. Central to the pathogens' virulence is manipulation of the host cell's cytoskeleton, which facilitates microbial invasion, multiplication, and avoidance of the innate immune response. IQGAP1 is a ubiquitously expressed scaffold protein that integrates diverse signaling cascades. Research has shown that IQGAP1 binds to and modulates the activity of multiple proteins that participate in bacterial invasion. Here, we review data that support a role for IQGAP1 in infectious disease via its ability to regulate the actin cytoskeleton. In addition, we explore other mechanisms by which IQGAP1 may be exploited by microbial pathogens. JF - FEBS Letters AU - Kim, Hugh AU - White, Colin D AU - Sacks, David B AD - Department of Translational Medicine, Brigham and Women's Hospital and Harvard Medical School, 1 Blackfan Circle, Boston, MA 02115, USA, sacksdb@mail.nih.gov Y1 - 2011/03/09/ PY - 2011 DA - 2011 Mar 09 SP - 723 EP - 729 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 585 IS - 5 SN - 0014-5793, 0014-5793 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Mortality KW - Data processing KW - Pathogens KW - IQGAP1 protein KW - Morbidity KW - scaffolds KW - Cytoskeleton KW - Virulence KW - Infectious diseases KW - Reviews KW - Actin KW - Immune response KW - A 01490:Miscellaneous KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904467546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=IQGAP1+in+microbial+pathogenesis%3A+Targeting+the+actin+cytoskeleton&rft.au=Kim%2C+Hugh%3BWhite%2C+Colin+D%3BSacks%2C+David+B&rft.aulast=Kim&rft.aufirst=Hugh&rft.date=2011-03-09&rft.volume=585&rft.issue=5&rft.spage=723&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/10.1016%2Fj.febslet.2011.01.041 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Virulence; Cytoskeleton; Mortality; Data processing; Infectious diseases; Reviews; Actin; Immune response; Pathogens; IQGAP1 protein; scaffolds; Morbidity DO - http://dx.doi.org/10.1016/j.febslet.2011.01.041 ER - TY - JOUR T1 - Immunological responses against Plasmodium falciparum Apical Membrane Antigen 1 vaccines vary depending on the population immunized AN - 869571245; 14511211 AB - Clinical development of malaria vaccines progresses from trials in malaria naieve adults to malaria exposed adults followed by malaria exposed children. It is not well known whether immune responses in non-target populations are predictive of those in target populations, particularly in African children. Therefore humoral responses in three different populations (U.S. adults, Malian adults and Malian children) were compared in this study. They were immunized with 80 [micro]g of Apical Membrane Antigen 1 (AMA1)/alhydrogel on days 0 and 28. Sera were collected on days 0 and 42; antibody levels were determined by ELISA and the functionality of antibodies was evaluated by Growth Inhibition Assay. After immunization, there was no significant difference in antibody levels between the Malian children and the Malian adults, but U.S. adults showed lower antibody levels. Vaccination did not significantly change growth-inhibitory activity in Malian adults, but inhibition increased significantly in both U.S. adults and Malian children. Vaccine-induced inhibitory activity was reversed by pre-incubation with AMA1 protein, but pre-existing infection-induced inhibition was not. This study shows that humoral responses elicited by the AMA1 vaccine varied depending on the population, most likely reflecting different levels of previous malaria exposure. Thus predicting immune responses from non-target populations is not desirable. JF - Vaccine AU - Miura, Kazutoyo AU - Zhou, Hong AU - Diouf, Ababacar AU - Tullo, Gregory AU - Moretz, Samuel E AU - Aebig, Joan A AU - Fay, Michael P AU - Miller, Louis H AU - Doumbo, Ogobara K AU - Sagara, Issaka AU - Dicko, Alassane AU - Long, Carole A AU - Ellis, Ruth D AD - Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA Y1 - 2011/03/09/ PY - 2011 DA - 2011 Mar 09 SP - 2255 EP - 2261 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 29 IS - 12 SN - 0264-410X, 0264-410X KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Apical Membrane Antigen 1 KW - Phase 1 trial KW - Phase 2 trial KW - Humoral immunity KW - ELISA KW - Growth inhibition assay KW - Apical membrane antigen 1 KW - Prediction KW - Enzyme-linked immunosorbent assay KW - Human diseases KW - Disease control KW - Environmental impact KW - Malaria KW - Plasmodium falciparum KW - Children KW - Clinical trials KW - AmA1 protein KW - Public health KW - USA KW - Antibodies KW - Antigens KW - Africa KW - Immune response KW - Vaccines KW - F 06905:Vaccines KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869571245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Immunological+responses+against+Plasmodium+falciparum+Apical+Membrane+Antigen+1+vaccines+vary+depending+on+the+population+immunized&rft.au=Miura%2C+Kazutoyo%3BZhou%2C+Hong%3BDiouf%2C+Ababacar%3BTullo%2C+Gregory%3BMoretz%2C+Samuel+E%3BAebig%2C+Joan+A%3BFay%2C+Michael+P%3BMiller%2C+Louis+H%3BDoumbo%2C+Ogobara+K%3BSagara%2C+Issaka%3BDicko%2C+Alassane%3BLong%2C+Carole+A%3BEllis%2C+Ruth+D&rft.aulast=Miura&rft.aufirst=Kazutoyo&rft.date=2011-03-09&rft.volume=29&rft.issue=12&rft.spage=2255&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2011.01.043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Prediction; Antibodies; Human diseases; Antigens; Environmental impact; Disease control; Malaria; Vaccines; Public health; Apical membrane antigen 1; Enzyme-linked immunosorbent assay; Immune response; Children; Clinical trials; AmA1 protein; Plasmodium falciparum; USA; Africa DO - http://dx.doi.org/10.1016/j.vaccine.2011.01.043 ER - TY - JOUR T1 - Oligosaccharide conjugates of Bordetella pertussis and bronchiseptica induce bactericidal antibodies, an addition to pertussis vaccine AN - 907157540; 14516924 AB - Pertussis is a highly contagious respiratory disease that is especially dangerous for infants and children. Despite mass vaccination, reported pertussis cases have increased in the United States and other parts of the world, probably because of increased awareness, improved diagnostic means, and waning vaccine-induced immunity among adolescents and adults. Licensed vaccines do not kill the organism directly; the addition of a component inducing bactericidal antibodies would improve vaccine efficacy. We investigated Bordetella pertussis and Bordetella bronchiseptica LPS-derived core oligosaccharide (OS) protein conjugates for their immunogenicity in mice. B. pertussis and B. bronchiseptica core OS were bound to aminooxylated BSA via their terminal Kdo residues. The two conjugates induced similar anti-B. pertussis LPS IgG levels in mice. B. bronchiseptica was investigated because it is easier to grow than B. pertussis. Using B. bronchiseptica genetically modified strains deficient in the O-specific polysaccharide, we isolated fractions of core OS with one to five repeats of the terminal trisaccharide, having at the nonreducing end a GlcNAc or GalNAc, and bound them to BSA at different densities. The highest antibody levels in mice were elicited by conjugates containing an average of 8-17 OS chains per protein and with one repeat of the terminal trisaccharide. Conjugate-induced antisera were bactericidal against B. pertussis, and the titers correlated with ELISA-measured antibody levels (r = 0.74). Such conjugates are easy to prepare and standardize; added to a recombinant pertussis toxoid, they may induce antibacterial and antitoxin immunity. JF - Proceedings of the National Academy of Sciences, USA AU - Kubler-Kielb, Joanna AU - Vinogradov, Evgeny AU - Lagergaard, Teresa AU - Ginzberg, Ariel AU - King, Jerry D AU - Preston, Andrew AU - Maskell, Duncan J AU - Pozsgay, Vince AU - Keith, Jerry M AU - Robbins, John B AU - Schneerson, Rachel AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 Y1 - 2011/03/08/ PY - 2011 DA - 2011 Mar 08 SP - 4087 EP - 4092 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 108 IS - 10 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Adolescence KW - Antisera KW - Antitoxins KW - Children KW - Immunity KW - Immunogenicity KW - Immunoglobulin G KW - Infants KW - Lipopolysaccharides KW - Pertussis KW - Polysaccharides KW - Toxoids KW - Vaccines KW - oligosaccharides KW - Bacteria KW - Bordetella pertussis KW - Bordetella bronchiseptica KW - F 06905:Vaccines KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907157540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Oligosaccharide+conjugates+of+Bordetella+pertussis+and+bronchiseptica+induce+bactericidal+antibodies%2C+an+addition+to+pertussis+vaccine&rft.au=Kubler-Kielb%2C+Joanna%3BVinogradov%2C+Evgeny%3BLagergaard%2C+Teresa%3BGinzberg%2C+Ariel%3BKing%2C+Jerry+D%3BPreston%2C+Andrew%3BMaskell%2C+Duncan+J%3BPozsgay%2C+Vince%3BKeith%2C+Jerry+M%3BRobbins%2C+John+B%3BSchneerson%2C+Rachel&rft.aulast=Kubler-Kielb&rft.aufirst=Joanna&rft.date=2011-03-08&rft.volume=108&rft.issue=10&rft.spage=4087&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Antitoxins; Pertussis; oligosaccharides; Adolescence; Immunity; Toxoids; Children; Polysaccharides; Antisera; Immunogenicity; Immunoglobulin G; Lipopolysaccharides; Vaccines; Infants; Bacteria; Bordetella pertussis; Bordetella bronchiseptica ER - TY - JOUR T1 - Development of a genetically-modified novel T-cell receptor for adoptive cell transfer against renal cell carcinoma AN - 869572021; 14524091 AB - A novel alpha / beta T-cell clone with broad reactivity against human clear cell renal cell carcinomas (RCC) was generated from a patient with renal cancer. The T-cell receptor (TCR) from this clone recognizes soluble TNF-related apoptosis inducing ligand bound to death receptor 4, a complex found on the surface of nearly all RCC. In this study, we modified this novel TCR by introducing amino acid (AA) substitutions in its complementarity determining region 2 (CDR2) and CDR3 regions of both chains, to increase its activity. We demonstrated that tumor recognition by PBL, retrovirally-transduced with these TCRs, was decreased or unchanged by substitutions in the TCR beta chain, and in the CDR2 alpha region. Yet some AA substitutions in the CDR3 alpha region at positions 109 and 112 could augment tumor recognition. Specifically, substituting phenylalanine for tyrosine at AA109 (109Y-F) and alanine or lysine for serine at AA112 (112S-K or 112 S-A) augmented tumor recognition. Increased benefit was seen on combining both AA substitutions and a retrovirus encoding the modified TCR 109Y-F/112S-K conferred the best tumor recognition to transduced PBL. This modified TCR retained the recognition pattern of parental clone HC/2G-1 against RCC lines, other tumors and normal tissues. These results document that CDR3 alpha plays an important role in the interaction of the HC/2G-1 TCR and its novel ligand. A phase I/II clinical trial, adoptively transferring autologous PBL transduced with this modified TCR has just begun in patients with metastatic RCC. JF - Journal of Immunological Methods AU - Wang, Qiong J AU - Hanada, Ken-ichi AU - Feldman, Steven A AU - Zhao, Yangbing AU - Inozume, Takashi AU - Yang, James C AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, USA Y1 - 2011/03/07/ PY - 2011 DA - 2011 Mar 07 SP - 43 EP - 51 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 366 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Alanine KW - Amino acid substitution KW - Amino acids KW - Apoptosis KW - Clear cells KW - Clinical trials KW - Kidney KW - Lymphocytes T KW - Lysine KW - Metastases KW - Phenylalanine KW - Retrovirus KW - Serine KW - T-cell receptor KW - Tumors KW - Tyrosine KW - double prime T-cell receptor KW - complementarity-determining region 3 KW - death receptors KW - renal cell carcinoma KW - F 06900:Methods KW - G 07730:Development & Cell Cycle KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869572021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Development+of+a+genetically-modified+novel+T-cell+receptor+for+adoptive+cell+transfer+against+renal+cell+carcinoma&rft.au=Wang%2C+Qiong+J%3BHanada%2C+Ken-ichi%3BFeldman%2C+Steven+A%3BZhao%2C+Yangbing%3BInozume%2C+Takashi%3BYang%2C+James+C&rft.aulast=Wang&rft.aufirst=Qiong&rft.date=2011-03-07&rft.volume=366&rft.issue=1-2&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2011.01.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - complementarity-determining region 3; T-cell receptor; Amino acid substitution; Amino acids; Apoptosis; Alanine; double prime T-cell receptor; Clear cells; Tyrosine; Lysine; Tumors; Clinical trials; Phenylalanine; Metastases; Retrovirus; renal cell carcinoma; Kidney; Lymphocytes T; death receptors; Serine DO - http://dx.doi.org/10.1016/j.jim.2011.01.002 ER - TY - CPAPER T1 - Synergism of Leptin Signaling and Post Translational Protein Oxidation in Bromodichloromethane Exposure Is Key to the Development of Steatohepatitis of Obesity T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313010670; 6046121 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Chatterjee, S AU - Clark, J AU - Kadiiska, M AU - Mason, R Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Oxidation KW - obesity KW - Synergism KW - Translation KW - Obesity KW - Bromodichloromethane KW - Leptin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313010670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Synergism+of+Leptin+Signaling+and+Post+Translational+Protein+Oxidation+in+Bromodichloromethane+Exposure+Is+Key+to+the+Development+of+Steatohepatitis+of+Obesity&rft.au=Chatterjee%2C+S%3BClark%2C+J%3BKadiiska%2C+M%3BMason%2C+R&rft.aulast=Chatterjee&rft.aufirst=S&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Neonatal Genistein Exposure Permanently Disrupts Oviduct Gene Expression and Tissue Architecture During Pregnancy T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313009210; 6047634 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Padilla-Banks, E AU - Jefferson, W AU - Wagner, S AU - Williams, C Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Pregnancy KW - Neonates KW - Gene expression KW - Genistein KW - Oviduct UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313009210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Neonatal+Genistein+Exposure+Permanently+Disrupts+Oviduct+Gene+Expression+and+Tissue+Architecture+During+Pregnancy&rft.au=Padilla-Banks%2C+E%3BJefferson%2C+W%3BWagner%2C+S%3BWilliams%2C+C&rft.aulast=Padilla-Banks&rft.aufirst=E&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Neonatal Genistein Exposure Causes Implantation Failure Because of Permanent Alterations in Uterine Morphology and Steroid Hormone Responses T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313009182; 6047633 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Jefferson, W AU - Wagner, S AU - Padilla-Banks, E AU - Williams, C Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Neonates KW - steroid hormones KW - Morphology KW - Uterus KW - Genistein KW - Steroid hormones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313009182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Neonatal+Genistein+Exposure+Causes+Implantation+Failure+Because+of+Permanent+Alterations+in+Uterine+Morphology+and+Steroid+Hormone+Responses&rft.au=Jefferson%2C+W%3BWagner%2C+S%3BPadilla-Banks%2C+E%3BWilliams%2C+C&rft.aulast=Jefferson&rft.aufirst=W&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - In Vitro Macrophage Cytotoxicity of Indium-Phosphide and Indium-Tin Oxide Particles Is Dependent upon Phagosome Acidification after Particle Uptake T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313006582; 6046014 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Gwinn, W AU - Shines, C AU - Bousquet, R AU - Morgan, D Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Particulates KW - Acidification KW - Cytotoxicity KW - Phagosomes KW - oxides KW - Macrophages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313006582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=In+Vitro+Macrophage+Cytotoxicity+of+Indium-Phosphide+and+Indium-Tin+Oxide+Particles+Is+Dependent+upon+Phagosome+Acidification+after+Particle+Uptake&rft.au=Gwinn%2C+W%3BShines%2C+C%3BBousquet%2C+R%3BMorgan%2C+D&rft.aulast=Gwinn&rft.aufirst=W&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Approaches for Incorporating Nonchemical Stressors into Cumulative Risk Assessments T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313005481; 6047228 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Rider, C AU - Simmons, J Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Risk assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313005481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Approaches+for+Incorporating+Nonchemical+Stressors+into+Cumulative+Risk+Assessments&rft.au=Rider%2C+C%3BSimmons%2C+J&rft.aulast=Rider&rft.aufirst=C&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The International Cooperation on Alternative Test Methods (ICATM): Translating Science to Provide Improved Public Health Safety Assessment Tools T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313000835; 6045857 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Stokes, W AU - Wind, M Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Public health KW - International cooperation KW - Health and safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313000835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=The+International+Cooperation+on+Alternative+Test+Methods+%28ICATM%29%3A+Translating+Science+to+Provide+Improved+Public+Health+Safety+Assessment+Tools&rft.au=Stokes%2C+W%3BWind%2C+M&rft.aulast=Stokes&rft.aufirst=W&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Cadmium-Induced Transformation of Human Stem Cells T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312997986; 6046593 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Tokar, E AU - Waalkes, M Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - stem cells KW - Transformation KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312997986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Cadmium-Induced+Transformation+of+Human+Stem+Cells&rft.au=Tokar%2C+E%3BWaalkes%2C+M&rft.aulast=Tokar&rft.aufirst=E&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Using Fewer Animals to Identify Chemical Eye Hazards: Revised Classification Criteria Necessary to Maintain Equivalent Hazard Labeling T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312997360; 6046956 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Stokes, W AU - Haseman, J AU - Lipscomb, E AU - Truax, J AU - Johnson, N AU - Jones, B AU - Allen, D Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Eye KW - classification KW - Classification KW - Hazards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312997360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Using+Fewer+Animals+to+Identify+Chemical+Eye+Hazards%3A+Revised+Classification+Criteria+Necessary+to+Maintain+Equivalent+Hazard+Labeling&rft.au=Stokes%2C+W%3BHaseman%2C+J%3BLipscomb%2C+E%3BTruax%2C+J%3BJohnson%2C+N%3BJones%2C+B%3BAllen%2C+D&rft.aulast=Stokes&rft.aufirst=W&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The Role of Annual Validation in Risk Management in Biosafety Level 3 Laboratories T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312997146; 6046952 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Harbourt, D AU - Glass, J AU - Osorio-Sanchez, J AU - Traum, T AU - Wilson, D Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Risk management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312997146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=The+Role+of+Annual+Validation+in+Risk+Management+in+Biosafety+Level+3+Laboratories&rft.au=Harbourt%2C+D%3BGlass%2C+J%3BOsorio-Sanchez%2C+J%3BTraum%2C+T%3BWilson%2C+D&rft.aulast=Harbourt&rft.aufirst=D&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Identification of Cadmium-Responsive Transcriptional Regulators of the C. Elegans Gene, Cdr-1 T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312996999; 6045714 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Fuhrman, L AU - Freedman, J Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Transcription UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312996999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Identification+of+Cadmium-Responsive+Transcriptional+Regulators+of+the+C.+Elegans+Gene%2C+Cdr-1&rft.au=Fuhrman%2C+L%3BFreedman%2C+J&rft.aulast=Fuhrman&rft.aufirst=L&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Environmental Predictors of U.S. County Mortality Patterns on a National Basis T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312996937; 6047002 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Chan, M AU - Weinhold, R AU - Thomas, R AU - Gohlke, J AU - Portier, C Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Mortality patterns KW - Mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312996937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Environmental+Predictors+of+U.S.+County+Mortality+Patterns+on+a+National+Basis&rft.au=Chan%2C+M%3BWeinhold%2C+R%3BThomas%2C+R%3BGohlke%2C+J%3BPortier%2C+C&rft.aulast=Chan&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Toxic Effects of Cadmium on Human Peripheral Lung Cells T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312996929; 6045712 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Person, R AU - Tokar, E AU - Waalkes, M Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - Lung KW - Cadmium KW - Pollution effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312996929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Toxic+Effects+of+Cadmium+on+Human+Peripheral+Lung+Cells&rft.au=Person%2C+R%3BTokar%2C+E%3BWaalkes%2C+M&rft.aulast=Person&rft.aufirst=R&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Characterization of the Hepatic Transcriptome Response to a Mixture of Low Molecular Weight Polybrominated Diphenyl Ethers: Disease, Signature, Network, and Pathway Analysis T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312996727; 6047028 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Auerbach, S AU - Shockley, K AU - Thomas, R AU - Machesky, N AU - Vallant, M AU - Hebert, C AU - Cunny, H AU - Dunnick, J Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Polybrominated diphenyl ethers KW - polybrominated diphenyl ethers KW - Gene expression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312996727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Characterization+of+the+Hepatic+Transcriptome+Response+to+a+Mixture+of+Low+Molecular+Weight+Polybrominated+Diphenyl+Ethers%3A+Disease%2C+Signature%2C+Network%2C+and+Pathway+Analysis&rft.au=Auerbach%2C+S%3BShockley%2C+K%3BThomas%2C+R%3BMachesky%2C+N%3BVallant%2C+M%3BHebert%2C+C%3BCunny%2C+H%3BDunnick%2C+J&rft.aulast=Auerbach&rft.aufirst=S&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Metallothionein and Acute Cadmiuminduced Dna Oxidative Damage T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312996436; 6045705 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Qu, W. AU - Cheng, L AU - Sun, Y AU - Mason, R AU - Waalkes, M Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Metallothionein KW - DNA damage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312996436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Metallothionein+and+Acute+Cadmiuminduced+Dna+Oxidative+Damage&rft.au=Qu%2C+W.%3BCheng%2C+L%3BSun%2C+Y%3BMason%2C+R%3BWaalkes%2C+M&rft.aulast=Qu&rft.aufirst=W.&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Validation of Best Detection Methods for Measuring Oxidative Stress T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312996378; 6046871 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Kadiiska, M Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - oxidative stress KW - Oxidative stress UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312996378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Validation+of+Best+Detection+Methods+for+Measuring+Oxidative+Stress&rft.au=Kadiiska%2C+M&rft.aulast=Kadiiska&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Final Results of an International Validation Study of an in Vitro ER Ta Test Method in BG- 1 Cells T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312995861; 6046455 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Casey, W AU - Ceger, P AU - Allen, D AU - Clark, G AU - Pazos, P AU - Grignard, E AU - de Lange, J AU - Bremer, S AU - Nakamura, M AU - Kojima, H AU - Stokes, W Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312995861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Final+Results+of+an+International+Validation+Study+of+an+in+Vitro+ER+Ta+Test+Method+in+BG-+1+Cells&rft.au=Casey%2C+W%3BCeger%2C+P%3BAllen%2C+D%3BClark%2C+G%3BPazos%2C+P%3BGrignard%2C+E%3Bde+Lange%2C+J%3BBremer%2C+S%3BNakamura%2C+M%3BKojima%2C+H%3BStokes%2C+W&rft.aulast=Casey&rft.aufirst=W&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Foxo1 Associated P27KIP1 Decrease Is Essential for Fenvalerate-Induced Cell Growth in Human Uterine Leiomyoma (UTLM) and Smooth Muscle Cells (UTSMC) T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312995457; 6046508 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Gao, X AU - Yu, L. AU - Castro, L AU - Moore, A AU - Sifre, M AU - Bortner, C AU - Dixon, D Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Smooth muscle KW - Cyclin-dependent kinase inhibitor p27 KW - Uterus KW - FOXO1 protein KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312995457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Foxo1+Associated+P27KIP1+Decrease+Is+Essential+for+Fenvalerate-Induced+Cell+Growth+in+Human+Uterine+Leiomyoma+%28UTLM%29+and+Smooth+Muscle+Cells+%28UTSMC%29&rft.au=Gao%2C+X%3BYu%2C+L.%3BCastro%2C+L%3BMoore%2C+A%3BSifre%2C+M%3BBortner%2C+C%3BDixon%2C+D&rft.aulast=Gao&rft.aufirst=X&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - PFOA-Induced Liver Effects in CD-1 and Pparalpha Knock-Out C57BL6 Mice T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312994251; 6046527 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Filgo, A AU - Hoenerhof, M AU - Kissling, G AU - White, S AU - Hines, E AU - Stanko, J AU - Fenton, S Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Mice KW - Liver UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312994251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=PFOA-Induced+Liver+Effects+in+CD-1+and+Pparalpha+Knock-Out+C57BL6+Mice&rft.au=Filgo%2C+A%3BHoenerhof%2C+M%3BKissling%2C+G%3BWhite%2C+S%3BHines%2C+E%3BStanko%2C+J%3BFenton%2C+S&rft.aulast=Filgo&rft.aufirst=A&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Estimating the Global Public Health Implications of Electricity and Coal Consumption T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312990949; 6048024 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Gohlke, J AU - Thomas, R AU - Portier, C AU - Woodward, A AU - Campbell-Lendrum, D AU - Pruss-Ustun, A AU - Hales, S Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Coal KW - Public health KW - Electricity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312990949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Estimating+the+Global+Public+Health+Implications+of+Electricity+and+Coal+Consumption&rft.au=Gohlke%2C+J%3BThomas%2C+R%3BPortier%2C+C%3BWoodward%2C+A%3BCampbell-Lendrum%2C+D%3BPruss-Ustun%2C+A%3BHales%2C+S&rft.aulast=Gohlke&rft.aufirst=J&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Contact Sensitizing Potential of Heptachlor in Female Balb/C Mice T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312982216; 6045538 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Frawley, R AU - Auttachoat, W AU - Smith, M AU - Brown, R AU - Guo, T AU - White Jr, K AU - Germolec, D Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Heptachlor KW - Mice KW - heptachlor UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312982216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Contact+Sensitizing+Potential+of+Heptachlor+in+Female+Balb%2FC+Mice&rft.au=Frawley%2C+R%3BAuttachoat%2C+W%3BSmith%2C+M%3BBrown%2C+R%3BGuo%2C+T%3BWhite+Jr%2C+K%3BGermolec%2C+D&rft.aulast=Frawley&rft.aufirst=R&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Metabolism and Disposition of 2-Methoxy-4- Nitroaniline in Male and Female Spraguedawley Rats and B6C3F1 Mice T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312977907; 6047711 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Surh, I AU - Waidyanatha, S AU - Zhan, Q AU - Warren, S AU - Patel, P AU - Black, S AU - Burgess, J AU - Mathews, J Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Metabolism KW - Mice KW - Rats KW - Disposition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312977907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Metabolism+and+Disposition+of+2-Methoxy-4-+Nitroaniline+in+Male+and+Female+Spraguedawley+Rats+and+B6C3F1+Mice&rft.au=Surh%2C+I%3BWaidyanatha%2C+S%3BZhan%2C+Q%3BWarren%2C+S%3BPatel%2C+P%3BBlack%2C+S%3BBurgess%2C+J%3BMathews%2C+J&rft.aulast=Surh&rft.aufirst=I&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Effects of Low-Dose Prenatal PFOA Exposure on the Mammary Gland of CD-1 Mice T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312977363; 6047057 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Macon, M AU - Villanueva, L AU - Zehr, R AU - Tatum-Gibbs, K AU - Strynar, M AU - Stanko, J AU - White, S AU - Helfant, L AU - Fenton, S Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Mice KW - prenatal experience KW - Prenatal experience KW - Mammary gland KW - Glands UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312977363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Effects+of+Low-Dose+Prenatal+PFOA+Exposure+on+the+Mammary+Gland+of+CD-1+Mice&rft.au=Macon%2C+M%3BVillanueva%2C+L%3BZehr%2C+R%3BTatum-Gibbs%2C+K%3BStrynar%2C+M%3BStanko%2C+J%3BWhite%2C+S%3BHelfant%2C+L%3BFenton%2C+S&rft.aulast=Macon&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Evaluating Toxicity of Engineered Nanomaterials: Issues with Conventional Toxicology Approaches T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312976639; 6045450 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Nadadur, S AU - Witzmann, F Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - nanotechnology KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312976639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Evaluating+Toxicity+of+Engineered+Nanomaterials%3A+Issues+with+Conventional+Toxicology+Approaches&rft.au=Nadadur%2C+S%3BWitzmann%2C+F&rft.aulast=Nadadur&rft.aufirst=S&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Identification of Transcriptional Regulators of C. Elegans Metallothionein Gene Expression T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312971741; 6045828 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Hall, J AU - Freedman, J Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Metallothionein KW - Gene expression KW - Transcription UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312971741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Identification+of+Transcriptional+Regulators+of+C.+Elegans+Metallothionein+Gene+Expression&rft.au=Hall%2C+J%3BFreedman%2C+J&rft.aulast=Hall&rft.aufirst=J&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - IKK? Function in Skin Inflammation and Turmorigenesis T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312970841; 6047218 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Hu, Y. Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Skin KW - Inflammation KW - IKK protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312970841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=IKK%3F+Function+in+Skin+Inflammation+and+Turmorigenesis&rft.au=Hu%2C+Y.&rft.aulast=Hu&rft.aufirst=Y.&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A Series of Autocrine and Paracrine Feedback Loops in Inflammation Pathways Are Required for Tumor Formation in Skin Carcinogenesis T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312970769; 6047217 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Yuspa, S Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Skin KW - tumors KW - Carcinogenesis KW - Feedback KW - Tumors KW - Paracrine signalling KW - Inflammation KW - Autocrine signalling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312970769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=A+Series+of+Autocrine+and+Paracrine+Feedback+Loops+in+Inflammation+Pathways+Are+Required+for+Tumor+Formation+in+Skin+Carcinogenesis&rft.au=Yuspa%2C+S&rft.aulast=Yuspa&rft.aufirst=S&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Autism and the Environment: Challenges and Opportunities for Advancing the Science T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312970435; 6047209 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Lawler, C Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Autism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312970435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Autism+and+the+Environment%3A+Challenges+and+Opportunities+for+Advancing+the+Science&rft.au=Lawler%2C+C&rft.aulast=Lawler&rft.aufirst=C&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Contrasting the Developmental and Adult Origins of Adverse Effects from Lead in the Draft Ntp Monograph on Low-Level Lead T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312969884; 6047136 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Rooney, A Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Lead KW - Side effects KW - Synopsis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312969884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Contrasting+the+Developmental+and+Adult+Origins+of+Adverse+Effects+from+Lead+in+the+Draft+Ntp+Monograph+on+Low-Level+Lead&rft.au=Rooney%2C+A&rft.aulast=Rooney&rft.aufirst=A&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Toxicology Study of Senna in c3b6f1/N trp53 Haploinsufficient Mice T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312966197; 6045675 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Surh, I AU - Brix, A AU - French, J AU - Dunnick, J Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Mice KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312966197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Toxicology+Study+of+Senna+in+c3b6f1%2FN+trp53+Haploinsufficient+Mice&rft.au=Surh%2C+I%3BBrix%2C+A%3BFrench%2C+J%3BDunnick%2C+J&rft.aulast=Surh&rft.aufirst=I&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Tumors and Proliferative Lesions in Adult Offspring after Maternal Exposure to Methylarsonous Acid During Gestation in cd1 Mice T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312966080; 6045673 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Waalkes, M AU - Diwan, B AU - Tokar, E AU - Thomas, D Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - offspring KW - Mice KW - tumors KW - Lesions KW - Progeny KW - Tumors KW - Gestation KW - Pregnancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312966080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Tumors+and+Proliferative+Lesions+in+Adult+Offspring+after+Maternal+Exposure+to+Methylarsonous+Acid+During+Gestation+in+cd1+Mice&rft.au=Waalkes%2C+M%3BDiwan%2C+B%3BTokar%2C+E%3BThomas%2C+D&rft.aulast=Waalkes&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Formation of Tamoxifen (TAM)-DNA Adducts in Monkeys and Humans T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312960199; 6048091 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Hernandez Ramon, E AU - John, K AU - Poirier, M AU - Woodward, R Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Adducts KW - Tamoxifen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312960199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Formation+of+Tamoxifen+%28TAM%29-DNA+Adducts+in+Monkeys+and+Humans&rft.au=Hernandez+Ramon%2C+E%3BJohn%2C+K%3BPoirier%2C+M%3BWoodward%2C+R&rft.aulast=Hernandez+Ramon&rft.aufirst=E&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Epithelia Malignantly Transformed by Arsenic or Cadmium Drives Nearby Normal Stem Cells towards a Malignant Phenotype T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312959652; 6047428 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Tokar, E AU - Waalkes, M AU - Xu, Y. Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - stem cells KW - Arsenic KW - Cadmium KW - Stem cells KW - Epithelia KW - Phenotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312959652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Epithelia+Malignantly+Transformed+by+Arsenic+or+Cadmium+Drives+Nearby+Normal+Stem+Cells+towards+a+Malignant+Phenotype&rft.au=Tokar%2C+E%3BWaalkes%2C+M%3BXu%2C+Y.&rft.aulast=Tokar&rft.aufirst=E&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - 13-Week Gavage Exposure to Gum Guggul Extract (GGE) Modulates Activity of Hepatic CYP2B and CYP3A in Harlan Sprague-Dawley Rats and B6C3F1 Mice T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312959637; 6047670 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Vallant, M AU - Hejtmancik, M AU - Gerken, D AU - Wyde, M AU - Granville, C Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Mice KW - Rats KW - Liver UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312959637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=13-Week+Gavage+Exposure+to+Gum+Guggul+Extract+%28GGE%29+Modulates+Activity+of+Hepatic+CYP2B+and+CYP3A+in+Harlan+Sprague-Dawley+Rats+and+B6C3F1+Mice&rft.au=Vallant%2C+M%3BHejtmancik%2C+M%3BGerken%2C+D%3BWyde%2C+M%3BGranville%2C+C&rft.aulast=Vallant&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Quantitative (Q)PCR Analysis of Rna Extracted from Formalin-Fixed Paraffin Embedded (FFPE) Liver from Aflatoxin B1 (AFB1) Treated Rats: Correlation with Microarray Data T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312957711; 6046534 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Merrick, B AU - Auerbach, S AU - Stockton, P AU - Foley, J AU - Malarkey, D AU - Sills, R AU - Irwin, R AU - Tice, R Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Aflatoxin B1 KW - Liver KW - Rats KW - Paraffin KW - Data processing KW - RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312957711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Quantitative+%28Q%29PCR+Analysis+of+Rna+Extracted+from+Formalin-Fixed+Paraffin+Embedded+%28FFPE%29+Liver+from+Aflatoxin+B1+%28AFB1%29+Treated+Rats%3A+Correlation+with+Microarray+Data&rft.au=Merrick%2C+B%3BAuerbach%2C+S%3BStockton%2C+P%3BFoley%2C+J%3BMalarkey%2C+D%3BSills%2C+R%3BIrwin%2C+R%3BTice%2C+R&rft.aulast=Merrick&rft.aufirst=B&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Tempol and Tempol-H Protect Cardiomyocytes from Nucleoside Reverse Transcriptase Inhibitor (NRTI)-Induced Mitochondrial Toxicity T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312957212; 6046713 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Nguyen, P AU - Liu, Y AU - Mitchell, J AU - Poirier, M Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - cardiomyocytes KW - Mitochondria KW - tempol KW - nucleoside reverse transcriptase inhibitors KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312957212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Tempol+and+Tempol-H+Protect+Cardiomyocytes+from+Nucleoside+Reverse+Transcriptase+Inhibitor+%28NRTI%29-Induced+Mitochondrial+Toxicity&rft.au=Nguyen%2C+P%3BLiu%2C+Y%3BMitchell%2C+J%3BPoirier%2C+M&rft.aulast=Nguyen&rft.aufirst=P&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - NTP Toxicology and Carcinogenesis Studies of Chromium T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312957079; 6046352 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Stout, M AU - Hooth, M Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Carcinogenesis KW - Toxicology KW - Chromium KW - Pollution effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312957079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=NTP+Toxicology+and+Carcinogenesis+Studies+of+Chromium&rft.au=Stout%2C+M%3BHooth%2C+M&rft.aulast=Stout&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Retinoic Acid Differentiated H9C2 Rat Cardiac Cells as a Model for Toxicity Screening T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312956286; 6046410 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Behrsing, H AU - Hamre III, J AU - Furniss, M AU - Mesa, D AU - Parchment, R Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - Retinoic acid KW - Heart KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312956286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Retinoic+Acid+Differentiated+H9C2+Rat+Cardiac+Cells+as+a+Model+for+Toxicity+Screening&rft.au=Behrsing%2C+H%3BHamre+III%2C+J%3BFurniss%2C+M%3BMesa%2C+D%3BParchment%2C+R&rft.aulast=Behrsing&rft.aufirst=H&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Genotoxicity of Styrene-Acrylonitrile Trimer in Weanling F344 Rats T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312955981; 6045763 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Chhabra, R AU - Hobbs, C AU - Recio, L AU - Winters, J AU - Shepard, K AU - Allen, P AU - Prajapati, M AU - Witt, K Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Genotoxicity KW - Rats UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312955981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Genotoxicity+of+Styrene-Acrylonitrile+Trimer+in+Weanling+F344+Rats&rft.au=Chhabra%2C+R%3BHobbs%2C+C%3BRecio%2C+L%3BWinters%2C+J%3BShepard%2C+K%3BAllen%2C+P%3BPrajapati%2C+M%3BWitt%2C+K&rft.aulast=Chhabra&rft.aufirst=R&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Minimum Material Characterizations for Nanotoxicology Studies: A Necessity or a Nuisance? T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312949845; 6046285 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Walker, N Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312949845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Minimum+Material+Characterizations+for+Nanotoxicology+Studies%3A+A+Necessity+or+a+Nuisance%3F&rft.au=Walker%2C+N&rft.aulast=Walker&rft.aufirst=N&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Activating PKC?1 at the Blood-Brain Barrier (BBB) Reverses Induction of P-Glycoprotein (PGP) Activity by Dioxin and Restores Drug Delivery to the CNS. T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312949603; 6045790 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Wang, X AU - Hawkins, B AU - Miller, D Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Dioxin KW - Drug delivery KW - Blood-brain barrier KW - P-Glycoprotein KW - Central nervous system KW - Protein kinase C KW - Chlorinated hydrocarbons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312949603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Activating+PKC%3F1+at+the+Blood-Brain+Barrier+%28BBB%29+Reverses+Induction+of+P-Glycoprotein+%28PGP%29+Activity+by+Dioxin+and+Restores+Drug+Delivery+to+the+CNS.&rft.au=Wang%2C+X%3BHawkins%2C+B%3BMiller%2C+D&rft.aulast=Wang&rft.aufirst=X&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Pathway Directed Molecular Analysis of Large Intestinal Tumors Induced in Fisher 344 Rats Exposed to Aloe Vera Whole Leaf Extract in Drinking Water T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312949079; 6045685 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Pandiri, A AU - Sills, R AU - Hoenerhof, M AU - Ton, T AU - Hong, H AU - Flake, G AU - Malarkey, D AU - Pogribny, I AU - Walker, N AU - Boudreau, M Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - tumors KW - Drinking water KW - Rats KW - Intestine KW - Tumors KW - Leaves KW - Drinking Water KW - Aloe vera UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312949079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Pathway+Directed+Molecular+Analysis+of+Large+Intestinal+Tumors+Induced+in+Fisher+344+Rats+Exposed+to+Aloe+Vera+Whole+Leaf+Extract+in+Drinking+Water&rft.au=Pandiri%2C+A%3BSills%2C+R%3BHoenerhof%2C+M%3BTon%2C+T%3BHong%2C+H%3BFlake%2C+G%3BMalarkey%2C+D%3BPogribny%2C+I%3BWalker%2C+N%3BBoudreau%2C+M&rft.aulast=Pandiri&rft.aufirst=A&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Exploring the Role of Nucleotide Excision Repair (NER) and Helicase in Zidovudine (AZT)- Induced Genotoxicity T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312948441; 6045556 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Momot, D AU - Nostrand, T AU - John, K AU - Poirier, M AU - Olivero, O Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Genotoxicity KW - DNA helicase KW - Nucleotide excision repair KW - Zidovudine KW - Nucleotides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312948441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Exploring+the+Role+of+Nucleotide+Excision+Repair+%28NER%29+and+Helicase+in+Zidovudine+%28AZT%29-+Induced+Genotoxicity&rft.au=Momot%2C+D%3BNostrand%2C+T%3BJohn%2C+K%3BPoirier%2C+M%3BOlivero%2C+O&rft.aulast=Momot&rft.aufirst=D&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Covalent Binding of 14 C 2-Methoxy-4- Nitroaniline in Male Sprague-Dawley Rats T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312935362; 6048079 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Surh, I AU - Fennell, T Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Rats UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312935362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Covalent+Binding+of+14+C+2-Methoxy-4-+Nitroaniline+in+Male+Sprague-Dawley+Rats&rft.au=Surh%2C+I%3BFennell%2C+T&rft.aulast=Surh&rft.aufirst=I&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Dimethylethanolamine Increased Serum Choline, but Did Not Alter [14C]-Choline Tissue Distribution in Wistar Han Rats T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312934465; 6047713 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Sanders, J AU - Doyle-Eisele, M AU - McDonald, J AU - Wegerski, C Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Rats KW - Choline KW - Serum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312934465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Dimethylethanolamine+Increased+Serum+Choline%2C+but+Did+Not+Alter+%5B14C%5D-Choline+Tissue+Distribution+in+Wistar+Han+Rats&rft.au=Sanders%2C+J%3BDoyle-Eisele%2C+M%3BMcDonald%2C+J%3BWegerski%2C+C&rft.aulast=Sanders&rft.aufirst=J&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Esr Spin-Trapping Investigation of Lung Free Radicals in an Animal Model of Interstitial Pneumonia Associated with Autoimmune Disease T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312930220; 6046947 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Kadiiska, M AU - Miyakawa, H AU - Jiang, J AU - Mason, R Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Animal models KW - autoimmune diseases KW - Lung KW - Pneumonia KW - Autoimmune diseases KW - Free radicals KW - Interstitial environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312930220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Esr+Spin-Trapping+Investigation+of+Lung+Free+Radicals+in+an+Animal+Model+of+Interstitial+Pneumonia+Associated+with+Autoimmune+Disease&rft.au=Kadiiska%2C+M%3BMiyakawa%2C+H%3BJiang%2C+J%3BMason%2C+R&rft.aulast=Kadiiska&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Evaluation of Subchronic Toxicity and Estrogenic Activity of Black Cohosh in Female Weanling B6C4F1 Mice Exposed by Gavage T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312926331; 6047810 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Mercado-Feliciano, M AU - Stout, M AU - Granville, C AU - Hejtmancik, M AU - Newbold, R AU - Vallant, M AU - Foster, P Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - Mice KW - estrogens KW - estrogenic activity KW - Sex hormones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312926331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Evaluation+of+Subchronic+Toxicity+and+Estrogenic+Activity+of+Black+Cohosh+in+Female+Weanling+B6C4F1+Mice+Exposed+by+Gavage&rft.au=Mercado-Feliciano%2C+M%3BStout%2C+M%3BGranville%2C+C%3BHejtmancik%2C+M%3BNewbold%2C+R%3BVallant%2C+M%3BFoster%2C+P&rft.aulast=Mercado-Feliciano&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Assessment of Mitochondrial Toxicity of Environmental Chemicals Using a Quantitative High-Throughput Screening Approach T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312925118; 6045931 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Attene-Ramos, M AU - Huang, R AU - Sakamuru, S AU - Shahane, S AU - Shou, L AU - Witt, K AU - Tice, R AU - Austin, C AU - Xia, M Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - Chemicals KW - Mitochondria KW - high-throughput screening KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312925118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Assessment+of+Mitochondrial+Toxicity+of+Environmental+Chemicals+Using+a+Quantitative+High-Throughput+Screening+Approach&rft.au=Attene-Ramos%2C+M%3BHuang%2C+R%3BSakamuru%2C+S%3BShahane%2C+S%3BShou%2C+L%3BWitt%2C+K%3BTice%2C+R%3BAustin%2C+C%3BXia%2C+M&rft.aulast=Attene-Ramos&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The Role of Stem Cells in Arsenic-Induced Transplacental Carcinogenesis T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312917683; 6048100 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Tokar, E AU - Waalkes, M Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - stem cells KW - Carcinogenesis KW - Transplacental carcinogenesis KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312917683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=The+Role+of+Stem+Cells+in+Arsenic-Induced+Transplacental+Carcinogenesis&rft.au=Tokar%2C+E%3BWaalkes%2C+M&rft.aulast=Tokar&rft.aufirst=E&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - rap80 Plays a Critical Role in Maintaining Genomic Stability T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312916884; 6048071 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Yin, Z AU - Jetten, A Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312916884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=rap80+Plays+a+Critical+Role+in+Maintaining+Genomic+Stability&rft.au=Yin%2C+Z%3BJetten%2C+A&rft.aulast=Yin&rft.aufirst=Z&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The Effects of Chemicals in the U.S. Epa'S Toxcast Library on Caenorhabditis Elegans and Zebrafish Development T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312912494; 6047180 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Boyd, W AU - Freedman, J AU - Smith, M Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - USA KW - EPA KW - Chemicals KW - Freshwater fish KW - Danio rerio KW - Caenorhabditis elegans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312912494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=The+Effects+of+Chemicals+in+the+U.S.+Epa%27S+Toxcast+Library+on+Caenorhabditis+Elegans+and+Zebrafish+Development&rft.au=Boyd%2C+W%3BFreedman%2C+J%3BSmith%2C+M&rft.aulast=Boyd&rft.aufirst=W&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Gold Nanoparticle Effects on Rat Ovarian Gene Expression T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312910272; 6046489 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Larson, J AU - Carvan III, M AU - Klaper, R AU - Hutz, R Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Gene expression KW - nanoparticles KW - Gold KW - Ovaries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312910272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Gold+Nanoparticle+Effects+on+Rat+Ovarian+Gene+Expression&rft.au=Larson%2C+J%3BCarvan+III%2C+M%3BKlaper%2C+R%3BHutz%2C+R&rft.aulast=Larson&rft.aufirst=J&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Molecular Effects of Inorganic and Organic Mercury in Caenorhabditis Elegans and Human Cells T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312908735; 6046423 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - McElwee, M AU - Freedman, J Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Mercury KW - Caenorhabditis elegans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312908735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Molecular+Effects+of+Inorganic+and+Organic+Mercury+in+Caenorhabditis+Elegans+and+Human+Cells&rft.au=McElwee%2C+M%3BFreedman%2C+J&rft.aulast=McElwee&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A PBPK Model of Micro and Nano Sized Fluorescent Polystyrene Spheres in Rats T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312907976; 6046156 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Chang, X AU - Sarlo, K AU - Walker, N AU - Blackburn, K AU - Clark, E AU - Grothaus, J AU - Portier, C Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Rats KW - polystyrene KW - Spheres UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312907976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=A+PBPK+Model+of+Micro+and+Nano+Sized+Fluorescent+Polystyrene+Spheres+in+Rats&rft.au=Chang%2C+X%3BSarlo%2C+K%3BWalker%2C+N%3BBlackburn%2C+K%3BClark%2C+E%3BGrothaus%2C+J%3BPortier%2C+C&rft.aulast=Chang&rft.aufirst=X&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Metabolism and Disposition of Nbutylparaben Following Oral and Dermal Administration T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312906669; 6047712 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Blystone, C AU - Mathews, J AU - Black, S AU - Brown, S AU - Patel, P AU - Etheridge, A AU - Waidyanatha, S Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Metabolism KW - Disposition KW - Skin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312906669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Metabolism+and+Disposition+of+Nbutylparaben+Following+Oral+and+Dermal+Administration&rft.au=Blystone%2C+C%3BMathews%2C+J%3BBlack%2C+S%3BBrown%2C+S%3BPatel%2C+P%3BEtheridge%2C+A%3BWaidyanatha%2C+S&rft.aulast=Blystone&rft.aufirst=C&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Human papillomavirus testing in the prevention of cervical cancer. AN - 855205821; 21282563 AB - Strong evidence now supports the adoption of cervical cancer prevention strategies that explicitly focus on persistent infection with the causal agent, human papillomavirus (HPV). To inform an evidence-based transition to a new public health approach for cervical cancer screening, we summarize the natural history and cervical carcinogenicity of HPV and discuss the promise and uncertainties of currently available screening methods. New HPV infections acquired at any age are virtually always benign, but persistent infections with one of approximately 12 carcinogenic HPV types explain virtually all cases of cervical cancer. In the absence of an overtly persistent HPV infection, the risk of cervical cancer is extremely low. Thus, HPV test results predict the risk of cervical cancer and its precursors (cervical intraepithelial neoplasia grade 3) better and longer than cytological or colposcopic abnormalities, which are signs of HPV infection. The logical and inevitable move to HPV-based cervical cancer prevention strategies will require longer screening intervals that will disrupt current gynecologic and cytology laboratory practices built on frequent screening. A major challenge will be implementing programs that do not overtreat HPV-positive women who do not have obvious long-term persistence of HPV or treatable lesions at the time of initial evaluation. The greatest potential for reduction in cervical cancer rates from HPV screening is in low-resource regions that can implement infrequent rounds of low-cost HPV testing and treatment. JF - Journal of the National Cancer Institute AU - Schiffman, Mark AU - Wentzensen, Nicolas AU - Wacholder, Sholom AU - Kinney, Walter AU - Gage, Julia C AU - Castle, Philip E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. schiffmm@mail.nih.gov Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 SP - 368 EP - 383 VL - 103 IS - 5 KW - Biomarkers, Tumor KW - 0 KW - DNA, Viral KW - Viral Vaccines KW - Index Medicus KW - Viral Vaccines -- administration & dosage KW - Evidence-Based Medicine KW - Humans KW - Algorithms KW - Disease Progression KW - Europe KW - Risk Assessment KW - Health Resources KW - Cost-Benefit Analysis KW - Biomarkers, Tumor -- blood KW - Time Factors KW - Colposcopy KW - Randomized Controlled Trials as Topic KW - Cervical Intraepithelial Neoplasia -- prevention & control KW - Carcinoma, Squamous Cell -- virology KW - Risk Factors KW - Carcinoma, Squamous Cell -- prevention & control KW - Cervical Intraepithelial Neoplasia -- virology KW - Incidence KW - DNA, Viral -- isolation & purification KW - Public Health -- trends KW - Adenocarcinoma -- prevention & control KW - United States -- epidemiology KW - Adenocarcinoma -- virology KW - Cell Transformation, Neoplastic KW - Female KW - Uterine Cervical Neoplasms -- prevention & control KW - Papillomavirus Infections -- diagnosis KW - Alphapapillomavirus -- isolation & purification KW - Papillomavirus Infections -- complications KW - Papillomavirus Infections -- virology KW - Uterine Cervical Neoplasms -- diagnosis KW - Mass Screening -- methods KW - Alphapapillomavirus -- genetics KW - Papillomavirus Infections -- epidemiology KW - Uterine Cervical Neoplasms -- epidemiology KW - Mass Screening -- economics KW - Vaginal Smears KW - Alphapapillomavirus -- pathogenicity KW - Uterine Cervical Neoplasms -- pathology KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855205821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Human+papillomavirus+testing+in+the+prevention+of+cervical+cancer.&rft.au=Schiffman%2C+Mark%3BWentzensen%2C+Nicolas%3BWacholder%2C+Sholom%3BKinney%2C+Walter%3BGage%2C+Julia+C%3BCastle%2C+Philip+E&rft.aulast=Schiffman&rft.aufirst=Mark&rft.date=2011-03-02&rft.volume=103&rft.issue=5&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/10.1093%2Fjnci%2Fdjq562 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-04-18 N1 - Date created - 2011-03-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 2007 Oct 18;357(16):1589-97 [17942872] Int J Cancer. 2007 Dec 15;121(12):2787-93 [17722112] Lancet. 2007 Nov 10;370(9599):1609-21 [17993361] Lancet. 2007 Nov 24;370(9601):1764-72 [17919718] J Infect Dis. 2008 Jan 15;197(2):279-82 [18179386] J Natl Cancer Inst. 2008 Apr 2;100(7):513-7 [18364507] Lancet Oncol. 2008 May;9(5):425-34 [18407790] Lancet Oncol. 2008 May;9(5):404-6 [18452848] Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1248-54 [18483347] Obstet Gynecol. 2008 Jun;111(6):1279-84 [18515509] J Clin Microbiol. 2008 Aug;46(8):2595-604 [18579716] J Adolesc Health. 2008 Oct;43(4 Suppl):S5-25, S25.e1-41 [18809145] Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2536-45 [18842994] Vaccine. 2008 Aug 19;26 Suppl 10:K1-16 [18847553] Vaccine. 2008 Aug 19;26 Suppl 10:K29-41 [18847555] Vaccine. 2008 Aug 19;26 Suppl 10:K42-52 [18847556] Vaccine. 2008 Aug 19;26 Suppl 10:K76-86 [18847560] BMJ. 2008;337:a1754 [18852164] Obstet Gynecol Clin North Am. 2008 Dec;35(4):537-48; vii [19061815] Int J Cancer. 2009 Jan 15;124(2):381-6 [19003961] Lancet Oncol. 2008 Oct;9(10):937-45 [18783988] Lancet Oncol. 2008 Oct;9(10):929-36 [18805733] J Natl Cancer Inst. 2009 Jan 21;101(2):88-99 [19141778] Cancer Epidemiol Biomarkers Prev. 2009 Mar;18(3):854-62 [19223559] Br J Cancer. 2009 Apr 7;100(7):1184-90 [19293802] J Natl Cancer Inst. 2009 Apr 1;101(7):475-87 [19318628] Curr Opin HIV AIDS. 2009 Jan;4(1):52-6 [19339939] N Engl J Med. 2009 Apr 2;360(14):1385-94 [19339719] Lancet Oncol. 2009 Apr;10(4):321-2 [19350698] Cancer Causes Control. 2009 May;20(4):417-35 [19002764] Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1060-9 [19336546] Cancer Treat Rev. 2009 May;35(3):210-20 [19261387] J Low Genit Tract Dis. 2009 Jul;13(3):137-44 [19550210] Lancet Oncol. 2009 Jul;10(7):672-82 [19540162] Int J Cancer. 2009 Aug 1;125(3):525-9 [19449379] CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49 [19474385] Lancet. 2009 Jul 25;374(9686):301-14 [19586656] BMJ. 2009;339:b2569 [19638649] Int J Cancer. 2009 Nov 15;125(10):2246-55 [19521965] Cancer Prev Res (Phila). 2009 Oct;2(10):868-78 [19789295] Ann Intern Med. 2009 Oct 20;151(8):538-45 [19841455] Arch Med Res. 2009 Aug;40(6):478-85 [19853188] Sex Transm Dis. 2009 Nov;36(11):675-9 [19773679] JAMA. 2009 Oct 28;302(16):1757-64 [19861667] Am J Clin Pathol. 2009 Jul;132(1):125-32 [19864243] Lancet Oncol. 2009 Nov;10(11):1022-3 [19767237] Obstet Gynecol. 2010 Feb;115(2 Pt 1):243-8 [20093895] J Natl Cancer Inst. 2010 Mar 3;102(5):315-24 [20157096] Lancet Oncol. 2010 Mar;11(3):249-57 [20089449] Virology. 2010 May 25;401(1):70-9 [20206957] BMC Cancer. 2010;10:111 [20334685] Cancer. 2010 Jun 1;116(11):2531-42 [20310056] Arch Intern Med. 2010 Jun 14;170(11):977-85 [20548011] Am J Clin Pathol. 2010 Jul;134(1):12-21 [20551261] Obstet Gynecol. 2010 Jul;116(1):76-84 [20567171] Am J Clin Pathol. 2010 Aug;134(2):193-9 [20660320] J Natl Cancer Inst. 2010 Dec 1;102(23):1794-804 [21098758] Cancer Epidemiol Biomarkers Prev. 2010 Dec;19(12):3044-54 [20952561] Int J Cancer. 2011 Feb 15;128(4):927-35 [20473886] Int J Cancer. 2011 Mar 15;128(6):1354-62 [20506504] Int J Cancer. 2010 Dec 15;127(12):2893-917 [21351269] J Natl Cancer Inst. 2000 Mar 1;92(5):397-402 [10700419] Ann Intern Med. 2000 May 16;132(10):810-9 [10819705] JAMA. 2001 Mar 21;285(11):1500-5 [11255427] Cancer Epidemiol Biomarkers Prev. 2001 Oct;10(10):1021-7 [11588127] JAMA. 2001 Dec 26;286(24):3106-14 [11754676] J Clin Pathol. 2002 Apr;55(4):244-65 [11919208] Nat Rev Cancer. 2002 May;2(5):342-50 [12044010] Lancet. 2002 Jul 20;360(9328):228-9 [12133661] J Infect Dis. 2002 Oct 15;186(8):1169-72 [12355370] Virus Res. 2002 Nov;89(2):229-40 [12445662] CA Cancer J Clin. 2002 Nov-Dec;52(6):342-62 [12469763] Am J Obstet Gynecol. 2003 Jun;188(6):1383-92 [12824967] Am J Obstet Gynecol. 2003 Jun;188(6):1401-5 [12824969] J Natl Cancer Inst. 2004 Feb 18;96(4):280-93 [14970277] Cancer Res. 2004 Jun 1;64(11):3878-84 [15172997] Am J Obstet Gynecol. 1969 Oct 1;105(3):386-93 [5810787] Obstet Gynecol. 1986 May;67(5):665-9 [3960438] Int J Cancer. 1989 Jul 15;44(1):40-7 [2787295] Int J Gynecol Pathol. 1993 Apr;12(2):186-92 [8463044] Int J Cancer. 1997 Apr 10;71(2):159-65 [9139836] Cancer Causes Control. 1997 Sep;8(5):755-63 [9328198] Obstet Gynecol. 1998 Jun;91(6):973-6 [9611007] Cancer. 1999 Apr 25;87(2):48-55 [10227593] J Natl Cancer Inst. 2005 Jan 19;97(2):147-50 [15657345] J Infect Dis. 2005 Jun 1;191(11):1796-807 [15871111] Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1157-64 [15894666] Virology. 2005 Jun 20;337(1):76-84 [15914222] J Natl Cancer Inst. 2005 Jul 20;97(14):1066-71 [16030304] J Natl Cancer Inst. 2005 Jul 20;97(14):1072-9 [16030305] J Pathol. 2006 Jan;208(2):152-64 [16362994] Int J Cancer. 2006 Mar 15;118(6):1481-95 [16206285] Lancet. 2006 Feb 11;367(9509):489-98 [16473126] Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):908-14 [16702369] PLoS Med. 2006 May;3(5):e138 [16573364] J Clin Oncol. 2006 Jun 10;24(17):2606-11 [16763272] Int J Cancer. 2006 Sep 1;119(5):1108-24 [16570271] Vaccine. 2006 Mar 30;24 Suppl 1:S16-22 [16219398] Obstet Gynecol. 2006 Aug;108(2):264-72 [16880294] Am J Obstet Gynecol. 2006 Aug;195(2):349-53 [16677597] Vaccine. 2006 Aug 31;24 Suppl 3:S3/11-25 [16949997] Vaccine. 2006 Aug 31;24 Suppl 3:S3/52-61 [16950018] Cancer Treat Rev. 2006 Nov;32(7):516-23 [17008015] Cancer. 2006 Oct 25;108(5):298-305 [16544318] Cancer Res. 2006 Oct 15;66(20):10112-9 [17047075] Int J Cancer. 2006 Dec 1;119(11):2677-84 [16991121] Cancer Res. 2006 Nov 15;66(22):11070-6 [17108147] Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):11-6 [17220326] Eur J Cancer. 2007 Feb;43(3):476-80 [17223540] Cancer. 2007 Feb 25;111(1):58-66 [17186505] CA Cancer J Clin. 2007 Mar-Apr;57(2):105-11 [17392387] J Infect Dis. 2007 Jun 1;195(11):1582-9 [17471427] Int J Cancer. 2007 Jul 15;121(2):361-7 [17354241] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] Cancer. 2007 Jun 25;111(3):145-53 [17487850] BMJ. 2007 Jul 7;335(7609):28 [17517761] Am J Obstet Gynecol. 2007 Jul;197(1):47.e1-8 [17618753] Dis Markers. 2007;23(4):297-313 [17627064] Dis Markers. 2007;23(4):315-30 [17627065] JAMA. 2007 Aug 15;298(7):743-53 [17699008] Lancet. 2007 Sep 8;370(9590):890-907 [17826171] Int J Gynecol Pathol. 2007 Oct;26(4):441-6 [17885496] Am J Obstet Gynecol. 2007 Oct;197(4):340-5 [17904956] Am J Obstet Gynecol. 2007 Oct;197(4):346-55 [17904957] Am J Obstet Gynecol. 2007 Oct;197(4):356.e1-6 [17904958] Int J Cancer. 2007 Nov 15;121(10):2218-24 [17657715] N Engl J Med. 2007 Oct 18;357(16):1579-88 [17942871] Comment In: J Natl Cancer Inst. 2011 Oct 5;103(19):1482-3; author reply 1483-4 [21859986] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jnci/djq562 ER - TY - JOUR T1 - The unique Alzheimer's β-amyloid triangular fibril has a cavity along the fibril axis under physiological conditions. AN - 853992265; 21299220 AB - Elucidating the structure of Aβ(1-40) fibrils is of interest in Alzheimer's disease research because it is required for designing therapeutics that target Aβ(1-40) fibril formation at an early stage of the disease. M35 is a crucial residue because of its potential oxidation and its strong interactions across β-strands and across β-sheets in Aβ fibrils. Experimentally, data for the three-fold symmetry structure of the Aβ(9-40) fibril suggest formation of tight hydrophobic core through M35 interactions across the fibril axis and strong I31-V39 interactions between different cross-β units. Herein, on the basis of experimental data, we probe conformers with three-fold symmetry of the full-length Aβ(1-40). Our all-atom molecular dynamics simulations in explicit solvent of conformers based on the ssNMR data reproduced experimental observations of M35-M35 and I31-V39 distances. Our interpretation of the experimental data suggests that the observed ∼5-7 Å M35-M35 distance in the fibril three-fold symmetry structure is likely to relate to M35 interactions along the fibril axis, rather than across the fibril axis, since our measured M35-M35 distances across the fibril axis are consistently above 15 Å. Consequently, we revealed that the unique Aβ(1-40) triangular structure has a large cavity along the fibril axis and that the N-termini can assist in the stabilization of the fibril by interacting with the U-turn domains or with the C-termini domains. Our findings, together with the recent cyroEM characterization of the hollow core in Aβ(1-42) fibrils, point to the relevance of a cavity in Aβ(1-40/1-42) oligomers which should be considered when targeting oligomer toxicity. JF - Journal of the American Chemical Society AU - Miller, Yifat AU - Ma, Buyong AU - Nussinov, Ruth AD - Center for Cancer Research Nanobiology Program NCI-Frederick, Frederick, Maryland 21702, USA. Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 SP - 2742 EP - 2748 VL - 133 IS - 8 KW - Amyloid beta-Peptides KW - 0 KW - Index Medicus KW - Protein Structure, Secondary KW - Models, Molecular KW - Molecular Dynamics Simulation KW - Amyloid beta-Peptides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853992265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=The+unique+Alzheimer%27s+%CE%B2-amyloid+triangular+fibril+has+a+cavity+along+the+fibril+axis+under+physiological+conditions.&rft.au=Miller%2C+Yifat%3BMa%2C+Buyong%3BNussinov%2C+Ruth&rft.aulast=Miller&rft.aufirst=Yifat&rft.date=2011-03-02&rft.volume=133&rft.issue=8&rft.spage=2742&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=1520-5126&rft_id=info:doi/10.1021%2Fja1100273 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-10 N1 - Date created - 2011-02-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Biochem. 1993 Oct;26(5):339-49 [8299204] J Biol Chem. 1992 Aug 25;267(24):17082-6 [1512246] J Biol Chem. 1999 Sep 3;274(36):25945-52 [10464339] Prog Neurobiol. 2004 Dec;74(6):323-49 [15649580] Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17342-7 [16293696] Biochemistry. 2006 Jan 17;45(2):498-512 [16401079] Biochemistry. 2006 May 2;45(17):5503-16 [16634632] Biophys J. 2007 Nov 1;93(9):3046-57 [17675353] Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18349-54 [19015532] Nat Methods. 2009 Mar;6(3):215-8 [19198596] Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4653-8 [19264960] J Phys Chem B. 2009 May 14;113(19):6692-702 [19419218] Biophys J. 2009 Aug 19;97(4):1168-77 [19686665] J Phys Chem B. 2010 Jan 14;114(1):463-70 [20014755] Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14128-33 [20660780] J Comput Chem. 2003 Aug;24(11):1348-56 [12827676] J Biol Chem. 2003 Sep 12;278(37):34882-9 [12840029] Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8378-82 [8078890] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ja1100273 ER - TY - CPAPER T1 - Sorafenib Is an Inhibitor of UGT1A1 but Is Metabolized by UGT1A9: Implications of UGT1A Genetic Variants on Sorafenib Exposure and Sorafenib-Induced Hyperbilirubinemia T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312977272; 6033058 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Peer, C AU - Sissung, T AU - Jain, L AU - Woo, S AU - Gardner, E AU - English, B AU - Figg, W AU - Kirkland, C AU - Federspiel, J Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - Hyperbilirubinemia KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312977272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=Sorafenib+Is+an+Inhibitor+of+UGT1A1+but+Is+Metabolized+by+UGT1A9%3A+Implications+of+UGT1A+Genetic+Variants+on+Sorafenib+Exposure+and+Sorafenib-Induced+Hyperbilirubinemia&rft.au=Peer%2C+C%3BSissung%2C+T%3BJain%2C+L%3BWoo%2C+S%3BGardner%2C+E%3BEnglish%2C+B%3BFigg%2C+W%3BKirkland%2C+C%3BFederspiel%2C+J&rft.aulast=Peer&rft.aufirst=C&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - abcb1 Polymorphisms Are Associated with Tariquidar-Induced Increases in Docetaxel Half-Life T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312976012; 6033142 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Sissung, T AU - Figg, W AU - Bates, S AU - Kelly, R AU - Venzon, D AU - Gardner, E AU - Kirkland, C AU - Fernandez, E Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - Pharmacology KW - Therapeutics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312976012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=abcb1+Polymorphisms+Are+Associated+with+Tariquidar-Induced+Increases+in+Docetaxel+Half-Life&rft.au=Sissung%2C+T%3BFigg%2C+W%3BBates%2C+S%3BKelly%2C+R%3BVenzon%2C+D%3BGardner%2C+E%3BKirkland%2C+C%3BFernandez%2C+E&rft.aulast=Sissung&rft.aufirst=T&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - NIH Therapeutics for Rare and Neglected Diseases (TRND) Program: Developing Clinical Candidates for Rare Diseases T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312948808; 6032897 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Austin, Christopher Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - Pharmacology KW - Therapeutics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312948808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=NIH+Therapeutics+for+Rare+and+Neglected+Diseases+%28TRND%29+Program%3A+Developing+Clinical+Candidates+for+Rare+Diseases&rft.au=Austin%2C+Christopher&rft.aulast=Austin&rft.aufirst=Christopher&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Background and Basic Concepts of Molecular and Functional Imaging T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312931319; 6032888 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Collins, Jerry Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312931319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=Background+and+Basic+Concepts+of+Molecular+and+Functional+Imaging&rft.au=Collins%2C+Jerry&rft.aulast=Collins&rft.aufirst=Jerry&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Weighting methods for population-based case-control studies with complex sampling AN - 940979500; 4280452 AB - Complex sample designs, involving stratified and/or multistage sampling with sample weighting, along with frequency matching, are used to select controls or cases for case-control studies. Examples that motivated this paper are the Kaposi sarcoma case-control study that was conducted in Sicily and the US kidney cancer case-control study. Survey design-based approaches can be inefficient for the analysis of case-control studies with frequency matching. We propose a weighting method that post-stratifies control sample weights to the estimated population distribution of the matching variables among cases. This weighting maintains the efficiency of frequency matching. The method proposed is evaluated by using simulation studies and is applied to the two case-control studies. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Li, Yan AU - Graubard, Barry I AU - Gaetano, Ralph Di AD - University of Texas, Arlington ; National Cancer Institute ; Westat Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 165 EP - 185 VL - 60 IS - 2 SN - 0035-9254, 0035-9254 KW - Economics KW - Case studies KW - Surveys KW - Sample surveys KW - Estimation KW - Sampling KW - U.S.A. KW - Weights and measures KW - Italy KW - Cancer KW - Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/940979500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Weighting+methods+for+population-based+case-control+studies+with+complex+sampling&rft.au=Li%2C+Yan%3BGraubard%2C+Barry+I%3BGaetano%2C+Ralph+Di&rft.aulast=Li&rft.aufirst=Yan&rft.date=2011-03-01&rft.volume=60&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=00359254&rft_id=info:doi/10.1111%2Fj.1467-9876.2010.00731.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 13518 7854; 7994; 11255 12228 10919; 1939 3617 6220; 2056 10902; 12429; 4403 7854; 11253 12429; 188 396 129; 433 293 14 DO - http://dx.doi.org/10.1111/j.1467-9876.2010.00731.x ER - TY - JOUR T1 - Probability and predictors of remission from life-time nicotine, alcohol, cannabis or cocaine dependence: results from the National Epidemiologic Survey on Alcohol and Related Conditions AN - 920067027; 4266390 AB - Aim To estimate the general and racial/ethnic specific cumulative probability of remission from nicotine alcohol cannabis or cocaine dependence, and to identify predictors of remission across substances. Design: Data were collected from structured diagnostic interviews using the Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV version. Setting: The 2001-2002 National Epidemiological Survey of Alcohol and Related Conditions (NESARC) surveyed a nationally representative sample from US adults (n = 43 093) selected in a three-stage sampling design. Participants: The subsamples of individuals with life-time DSM-IV diagnosis of dependence on nicotine (n = 6937), alcohol (n = 4781), cannabis (n = 530) and cocaine (n = 408). Measurements: Cumulative probability estimates of dependence remission for the general population and across racial/ethnic groups. Hazard ratios for remission from dependence. Findings: Life-time cumulative probability estimates of dependence remission were 83.7% for nicotine, 90.6% for alcohol, 97.2% for cannabis and 99.2% for cocaine. Half of the cases of nicotine, alcohol, cannabis and cocaine dependence remitted approximately 26, 14, 6 and 5 years after dependence onset, respectively. Males, Blacks and individuals with diagnosis of personality disorders and history of substance use comorbidity exhibited lower hazards of remission for at least two substances. Conclusions: A significant proportion of individuals with dependence on nicotine, alcohol, cannabis or cocaine achieve remission at some point in their life-time, although the probability and time to remission varies by substance and racial/ethnic group. Several predictors of remission are shared by at least two substances, suggesting that the processes of remission overlap. The lower rates of remission of individuals with comorbid personality or substance use disorders highlight the need for providing coordinated psychiatric and substance abuse interventions. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Wang, Shuai AU - Grant, Bridget F AU - Blanco, Carlos AU - Lopez-Quintero, Catalina AU - Hasin, Deborah S AU - Cobos, José Pérez de los AU - Pines, Abigail AD - Columbia University ; Hospital de la Santa Creu i Sant Pau, Barcelona ; National Institutes of Health, Bethesda Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 657 EP - 669 VL - 106 IS - 3 SN - 0965-2140, 0965-2140 KW - Sociology KW - Smoking KW - Alcohol KW - Cannabis KW - Tobacco KW - Surveys KW - Substance use KW - Substance abuse KW - Ethnic groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920067027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Probability+and+predictors+of+remission+from+life-time+nicotine%2C+alcohol%2C+cannabis+or+cocaine+dependence%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions&rft.au=Wang%2C+Shuai%3BGrant%2C+Bridget+F%3BBlanco%2C+Carlos%3BLopez-Quintero%2C+Catalina%3BHasin%2C+Deborah+S%3BCobos%2C+Jos%C3%A9+P%C3%A9rez+de+los%3BPines%2C+Abigail&rft.aulast=Wang&rft.aufirst=Shuai&rft.date=2011-03-01&rft.volume=106&rft.issue=3&rft.spage=657&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2010.03194.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12429; 909; 12766 3055 798 10286; 11755 5707 6071 1542 11325; 1942 3755; 4424; 12357; 12356 12357 DO - http://dx.doi.org/10.1111/j.1360-0443.2010.03194.x ER - TY - JOUR T1 - Phasic and sustained fear in humans elicits distinct patterns of brain activity AN - 910637121; 14352752 AB - Aversive events are typically more debilitating when they occur unpredictably than predictably. Studies in humans and animals indicate that predictable and unpredictable aversive events can induce phasic and sustained fear, respectively. Research in rodents suggests that anatomically related but distinct neural circuits may mediate phasic and sustained fear. We explored this issue in humans by examining threat predictability in three virtual reality contexts, one in which electric shocks were predictably signaled by a cue, a second in which shocks occurred unpredictably but never paired with a cue, and a third in which no shocks were delivered. Evidence of threat-induced phasic and sustained fear was presented using fear ratings and skin conductance. Utilizing recent advances in functional magnetic resonance imaging (fMRI), we were able to conduct whole-brain fMRI at relatively high spatial resolution and still have enough sensitivity to detect transient and sustained signal changes in the basal forebrain. We found that both predictable and unpredictable threat evoked transient activity in the dorsal amygdala, but that only unpredictable threat produced sustained activity in a forebrain region corresponding to the bed nucleus of the stria terminalis complex. Consistent with animal models hypothesizing a role for the cortex in generating sustained fear, sustained signal increases to unpredictable threat were also found in anterior insula and a frontoparietal cortical network associated with hypervigilance. In addition, unpredictable threat led to transient activity in the ventral amygdala-hippocampal area and pregenual anterior cingulate cortex, as well as transient activation and subsequent deactivation of subgenual anterior cingulate cortex, limbic structures that have been implicated in the regulation of emotional behavior and stress responses. In line with basic findings in rodents, these results provide evidence that phasic and sustained fear in humans may manifest similar signs of distress, but appear to be associated with different patterns of neural activity in the human basal forebrain. JF - NeuroImage AU - Alvarez, Ruben P AU - Chen, Gang AU - Bodurka, Jerzy AU - Kaplan, Raphael AU - Grillon, Christian AD - Mood and Anxiety Disorders Program, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA, ralvarez@laureateinstitute.org Y1 - 2011/03/01/ PY - 2011 DA - 2011 Mar 01 SP - 389 EP - 400 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 55 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Amygdala KW - Fear KW - W 30910:Imaging KW - N3:11001 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/910637121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Phasic+and+sustained+fear+in+humans+elicits+distinct+patterns+of+brain+activity&rft.au=Alvarez%2C+Ruben+P%3BChen%2C+Gang%3BBodurka%2C+Jerzy%3BKaplan%2C+Raphael%3BGrillon%2C+Christian&rft.aulast=Alvarez&rft.aufirst=Ruben&rft.date=2011-03-01&rft.volume=55&rft.issue=1&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.11.057 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Fear DO - http://dx.doi.org/10.1016/j.neuroimage.2010.11.057 ER - TY - JOUR T1 - Inefficacy Interim Monitoring Procedures in Randomized Clinical Trials: The Need to Report AN - 908013921; 2011-125422 AB - If definitive evidence concerning treatment effectiveness becomes available from an ongoing randomized clinical trial, then the trial could be stopped early, with the public release of results benefiting current and future patients. However, stopping an ongoing trial based on accruing outcome data requires methodological rigor to preserve validity of the trial conclusions. This has led to the use of formal interim monitoring procedures, which include inefficacy monitoring that will stop a trial early when the experimental treatment appears not to be working. For participants, inefficacy monitoring is especially important as it ensures that they are not being treated worse than if they had not enrolled on the trial. We discuss the importance of reporting with trial results the formal interim inefficacy monitoring guidelines that were utilized, and, if none were used, the reasons for their absence. A survey of two leading medical journals suggests that this is not current practice. Adapted from the source document. JF - The American Journal of Bioethics AU - Korn, Edward L AU - Freidlin, Boris AD - National Cancer Institute Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 2 EP - 10 PB - Taylor & Francis, Philadelphia PA VL - 11 IS - 3 SN - 1526-5161, 1526-5161 KW - Law and ethics - Ethics KW - Health conditions and policy - Medicine and health care KW - Administration of justice - Legal procedure KW - Education and education policy - Statistics, research, research methods, and research support KW - futility interim monitoring data and safety monitoring boards early stopping interim analysis randomized trial clinical research KW - Bioethics KW - Surveys KW - Patients KW - Evidence KW - Clinical trials KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/908013921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Bioethics&rft.atitle=Inefficacy+Interim+Monitoring+Procedures+in+Randomized+Clinical+Trials%3A+The+Need+to+Report&rft.au=Korn%2C+Edward+L%3BFreidlin%2C+Boris&rft.aulast=Korn&rft.aufirst=Edward&rft.date=2011-03-01&rft.volume=11&rft.issue=3&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Bioethics&rft.issn=15265161&rft_id=info:doi/10.1080%2F15265161.2010.546471 LA - English DB - PAIS Index N1 - Date revised - 2011-12-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Bioethics; Clinical trials; Patients; Evidence; Surveys DO - http://dx.doi.org/10.1080/15265161.2010.546471 ER - TY - JOUR T1 - Angiotensin II AT sub(1) Receptor Blockade Ameliorates Brain Inflammation AN - 907158087; 14378273 AB - Brain inflammation has a critical role in the pathophysiology of brain diseases of high prevalence and economic impact, such as major depression, schizophrenia, post-traumatic stress disorder, Parkinson's and Alzheimer's disease, and traumatic brain injury. Our results demonstrate that systemic administration of the centrally acting angiotensin II AT sub(1) receptor blocker (ARB) candesartan to normotensive rats decreases the acute brain inflammatory response to administration of the bacterial endotoxin lipopolysaccharide (LPS), a model of brain inflammation. The broad anti-inflammatory effects of candesartan were seen across the entire inflammatory cascade, including decreased production and release to the circulation of centrally acting proinflammatory cytokines, repression of nuclear transcription factors activation in the brain, reduction of gene expression of brain proinflammatory cytokines, cytokine and prostanoid receptors, adhesion molecules, proinflammatory inducible enzymes, and reduced microglia activation. These effects are widespread, occurring not only in well-known brain target areas for circulating proinflammatory factors and LPS, that is, hypothalamic paraventricular nucleus and the subfornical organ, but also in the prefrontal cortex, hippocampus, and amygdala. Candesartan reduced the associated anorexic effects, and ameliorated associated body weight loss and anxiety. Direct anti-inflammatory effects of candesartan were also documented in cultured rat microglia, cerebellar granule cells, and cerebral microvascular endothelial cells. ARBs are widely used in the treatment of hypertension and stroke, and their anti-inflammatory effects contribute to reduce renal and cardiac failure. Our results indicate that these compounds may offer a novel and safe therapeutic approach for the treatment of brain disorders. JF - Neuropsychopharmacology AU - Benicky, Julius AU - Sanchez-Lemus, Enrique AU - Honda, Masaru AU - Pang, Tao AU - Orecna, Martina AU - Wang, Juan AU - Leng, Yan AU - Chuang, De-Maw AU - Saavedra, Juan M AD - Section on Pharmacology, Division of Intramural Research Programs, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 857 EP - 870 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 36 IS - 4 SN - 0893-133X, 0893-133X KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Anxiety KW - Parkinson's disease KW - Alzheimer's disease KW - Cerebellum KW - Paraventricular nucleus KW - Gene expression KW - Endothelial cells KW - Schizophrenia KW - Mental disorders KW - Lipopolysaccharides KW - Cytokines KW - Traumatic brain injury KW - Heart KW - Depression KW - Stroke KW - Enzymes KW - Renal failure KW - prostaglandin receptors KW - Microglia KW - Angiotensin II KW - Post-traumatic stress disorder KW - Inflammation KW - Body weight loss KW - Neurodegenerative diseases KW - Subfornical organ KW - Movement disorders KW - Transcription factors KW - Kidney KW - Amygdala KW - Cortex (prefrontal) KW - J 02350:Immunology KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907158087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology&rft.atitle=Angiotensin+II+AT+sub%281%29+Receptor+Blockade+Ameliorates+Brain+Inflammation&rft.au=Benicky%2C+Julius%3BSanchez-Lemus%2C+Enrique%3BHonda%2C+Masaru%3BPang%2C+Tao%3BOrecna%2C+Martina%3BWang%2C+Juan%3BLeng%2C+Yan%3BChuang%2C+De-Maw%3BSaavedra%2C+Juan+M&rft.aulast=Benicky&rft.aufirst=Julius&rft.date=2011-03-01&rft.volume=36&rft.issue=4&rft.spage=857&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/10.1038%2Fnpp.2010.225 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Anxiety; Parkinson's disease; Alzheimer's disease; Cerebellum; Paraventricular nucleus; Schizophrenia; Endothelial cells; Gene expression; Mental disorders; Cytokines; Lipopolysaccharides; Traumatic brain injury; Heart; Depression; Stroke; Renal failure; Enzymes; prostaglandin receptors; Angiotensin II; Microglia; Post-traumatic stress disorder; Inflammation; Body weight loss; Neurodegenerative diseases; Subfornical organ; Movement disorders; Transcription factors; Kidney; Amygdala; Cortex (prefrontal) DO - http://dx.doi.org/10.1038/npp.2010.225 ER - TY - JOUR T1 - Rhesus and Human Cytomegalovirus Glycoprotein L Are Required for Infection and Cell-to-Cell Spread of Virus but Cannot Complement Each Other AN - 907157905; 14341397 AB - Rhesus cytomegalovirus (RhCMV), the homolog of human cytomegalovirus (HCMV), serves as a model for understanding the pathogenesis of HCMV and for developing candidate vaccines. In order to develop a replication-defective virus as a vaccine candidate, we constructed RhCMV with glycoprotein L (gL) deleted. RhCMV gL was essential for viral replication, and virus with gL deleted could only replicate in cells expressing RhCMV gL. Noncomplementing cells infected with RhCMV with gL deleted released intact, noninfectious RhCMV particles that were indistinguishable from wild-type RhCMV by electron microscopy and could be rescued by treatment of cells with polyethylene glycol. In addition, noncomplementing cells infected with RhCMV with gL deleted produced levels of gB, the major target of neutralizing antibodies, at levels similar to those observed in cells infected with wild-type RhCMV. Since RhCMV and HCMV gL share 53% amino acid identity, we determined whether the two proteins could complement the heterologous virus. Cells transfected with an HCMV bacterial artificial chromosome with gL deleted yielded virus that could replicate in human cells expressing HCMV gL. This is the second HCMV mutant with an essential glycoprotein deleted that has been complemented in cell culture. Finally, we found that HCMV gL could not complement the replication of RhCMV with gL deleted and that RhCMV gL could not complement the replication of HCMV with gL deleted. These data indicate that RhCMV and HCMV gL are both essential for replication of their corresponding viruses and, although the two gLs are highly homologous, they are unable to complement each another. JF - Journal of Virology AU - Bowman, JJason AU - Lacayo, Juan C AU - Burbelo, Peter AU - Fischer, Elizabeth R AU - Cohen, Jeffrey I AD - Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2011/03/01/ PY - 2011 DA - 2011 Mar 01 SP - 2089 EP - 2099 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 85 IS - 5 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Amino acids KW - Data processing KW - Replication KW - Cell culture KW - Infection KW - Bacterial artificial chromosomes KW - Human cytomegalovirus KW - Antibodies KW - Glycoproteins KW - Vaccines KW - Polyethylene glycol KW - Electron microscopy KW - J 02310:Genetics & Taxonomy KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907157905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Rhesus+and+Human+Cytomegalovirus+Glycoprotein+L+Are+Required+for+Infection+and+Cell-to-Cell+Spread+of+Virus+but+Cannot+Complement+Each+Other&rft.au=Bowman%2C+JJason%3BLacayo%2C+Juan+C%3BBurbelo%2C+Peter%3BFischer%2C+Elizabeth+R%3BCohen%2C+Jeffrey+I&rft.aulast=Bowman&rft.aufirst=JJason&rft.date=2011-03-01&rft.volume=85&rft.issue=5&rft.spage=2089&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Bacterial artificial chromosomes; Antibodies; Data processing; Amino acids; Replication; Cell culture; Vaccines; Glycoproteins; Infection; Polyethylene glycol; Electron microscopy; Human cytomegalovirus ER - TY - JOUR T1 - Production of active recombinant eIF5A: reconstitution in E.coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes AN - 907157634; 14388130 AB - Eukaryotic translation initiation factor 5A (eIF5A) is the only cellular protein that contains the polyamine-modified lysine, hypusine [N epsilon -(4-amino-2-hydroxybutyl)lysine]. Hypusine occurs only in eukaryotes and certain archaea, but not in eubacteria. It is formed post-translationally by two consecutive enzymatic reactions catalyzed by deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH). Hypusine modification is essential for the activity of eIF5A and for eukaryotic cell proliferation. eIF5A binds to the ribosome and stimulates translation in a hypusine-dependent manner, but its mode of action in translation is not well understood. Since quantities of highly pure hypusine-modified eIF5A is desired for structural studies as well as for determination of its binding sites on the ribosome, we have used a polycistronic vector, pST39, to express eIF5A alone, or to co-express human eIF5A-1 with DHS or with both DHS and DOHH in Escherichia coli cells, to engineer recombinant proteins, unmodified eIF5A, deoxyhypusine- or hypusine-modified eIF5A. We have accomplished production of three different forms of recombinant eIF5A in high quantity and purity. The recombinant hypusine-modified eIF5A was as active in methionyl-puromycin synthesis as the native, eIF5A (hypusine form) purified from mammalian tissue. The recombinant eIF5A proteins will be useful tools in future structure/function and the mechanism studies in translation. JF - Protein Engineering AU - Park, Jong Hwan AU - Dias, Camila AO AU - Lee, Seung Bum AU - Valentini, Sandro R AU - Sokabe, Masaaki AU - Fraser, Christopher S AU - Park, Myung Hee AD - Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4340, USA Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 301 EP - 309 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 24 IS - 3 SN - 0269-2139, 0269-2139 KW - Biotechnology and Bioengineering Abstracts KW - Archaea KW - Post-translation KW - Eubacteria KW - Structure-function relationships KW - Translation initiation KW - Escherichia coli KW - Lysine KW - Enzymes KW - Ribosomes KW - Cell proliferation KW - Hydroxylase KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907157634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Engineering&rft.atitle=Production+of+active+recombinant+eIF5A%3A+reconstitution+in+E.coli+of+eukaryotic+hypusine+modification+of+eIF5A+by+its+coexpression+with+modifying+enzymes&rft.au=Park%2C+Jong+Hwan%3BDias%2C+Camila+AO%3BLee%2C+Seung+Bum%3BValentini%2C+Sandro+R%3BSokabe%2C+Masaaki%3BFraser%2C+Christopher+S%3BPark%2C+Myung+Hee&rft.aulast=Park&rft.aufirst=Jong&rft.date=2011-03-01&rft.volume=24&rft.issue=3&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Protein+Engineering&rft.issn=02692139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Post-translation; Translation initiation; Structure-function relationships; Enzymes; Lysine; Ribosomes; Hydroxylase; Cell proliferation; Archaea; Eubacteria; Escherichia coli ER - TY - JOUR T1 - Defining the Plasmid-Borne Restriction-Modification Systems of the Lyme Disease Spirochete Borrelia burgdorferi AN - 907155171; 14344960 AB - The restriction-modification (R-M) systems of many bacteria present a barrier to the stable introduction of foreign DNA. The Lyme disease spirochete Borrelia burgdorferi has two plasmid-borne putative R-M genes, bbe02 and bbq67, whose presence limits transformation by shuttle vector DNA from Escherichia coli. We show that both the bbe02 and bbq67 loci in recipient B. burgdorferi limit transformation with shuttle vector DNA from E. coli, irrespective of its dam, dcm, or hsd methylation status. However, plasmid DNA purified from B. burgdorferi transformed naieve B. burgdorferi much more efficiently than plasmid DNA from E. coli, particularly when the bbe02 and bbq67 genotypes of the B. burgdorferi DNA source matched those of the recipient. We detected adenine methylation of plasmid DNA prepared from B. burgdorferi that carried bbe02 and bbq67. These results indicate that the bbe02 and bbq67 loci of B. burgdorferi encode distinct R-M enzymes that methylate endogenous DNA and cleave foreign DNA lacking the same sequence-specific modification. Our findings have basic implications for horizontal gene transfer among B. burgdorferi strains with distinct plasmid contents. Further characterization and identification of the nucleotide sequences recognized by BBE02 and BBQ67 will facilitate efficient genetic manipulation of this pathogenic spirochete. JF - Journal of Bacteriology AU - M Rego, Ryan O AU - Bestor, Aaron AU - Rosa, Patricia A AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, regor@niaid.nih.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 1161 EP - 1171 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 193 IS - 5 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Transformation KW - Borrelia burgdorferi KW - Nucleotide sequence KW - Enzymes KW - shuttle vectors KW - Genotypes KW - Plasmids KW - Spirochetes KW - Escherichia coli KW - DNA methylation KW - Adenine KW - Restriction-modification KW - Lyme disease KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907155171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Defining+the+Plasmid-Borne+Restriction-Modification+Systems+of+the+Lyme+Disease+Spirochete+Borrelia+burgdorferi&rft.au=M+Rego%2C+Ryan+O%3BBestor%2C+Aaron%3BRosa%2C+Patricia+A&rft.aulast=M+Rego&rft.aufirst=Ryan&rft.date=2011-03-01&rft.volume=193&rft.issue=5&rft.spage=1161&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01176-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Number of references - 58 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Transformation; Spirochetes; Nucleotide sequence; Adenine; DNA methylation; Enzymes; Restriction-modification; Genotypes; shuttle vectors; Plasmids; Lyme disease; Borrelia burgdorferi; Escherichia coli DO - http://dx.doi.org/10.1128/JB.01176-10 ER - TY - JOUR T1 - Chronic escitalopram treatment restores spatial learning, monoamine levels, and hippocampal long-term potentiation in an animal model of depression AN - 904467887; 14395856 AB - Rationale: The neural basis of depression-associated cognitive impairment remains poorly understood, and the effect of antidepressants on learning and synaptic plasticity in animal models of depression is unknown. In our previous study, learning was impaired in the neonatal clomipramine model of endogenous depression. However, it is not known whether the cognitive impairment in this model responds to antidepressant treatment, and the electrophysiological and neurochemical bases remain to be determined. Objectives: To address this, we assessed the effects of escitalopram treatment on spatial learning and memory in the partially baited radial arm maze (RAM) task and long-term potentiation (LTP) in the Schaffer collateral-CA1 synapses in neonatal clomipramine-exposed rats. Also, alterations in the levels of biogenic amines and acetylcholinesterase (AChE) activity were estimated. Results: Fourteen days of escitalopram treatment restored the mobility and preference to sucrose water in the forced swim and sucrose consumption tests, respectively. The learning impairment in the RAM was reversed by escitalopram treatment. Interestingly, CA1-LTP was decreased in the neonatal clomipramine-exposed rats, which was restored by escitalopram treatment. Monoamine levels and AChE activity were decreased in several brain regions, which were restored by chronic escitalopram treatment. Conclusions: Thus, we demonstrate that hippocampal LTP is decreased in this animal model of depression, possibly explaining the learning deficits. Further, the reversal of learning and electrophysiological impairments by escitalopram reveals the important therapeutic effects of escitalopram that could benefit patients suffering from depression. JF - Psychopharmacology AU - Bhagya, V AU - Srikumar, B N AU - Raju, T R AU - Rao, Shankaranarayana, BS AD - Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Hosur Road, PB # 2900, Bangalore, 560 029, India, bssrao@nimhans.kar.nic.in Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 477 EP - 494 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany VL - 214 IS - 2 SN - 0033-3158, 0033-3158 KW - Toxicology Abstracts; Animal Behavior Abstracts; CSA Neurosciences Abstracts KW - Acetylcholinesterase KW - Animal models KW - Antidepressants KW - Biogenic amines KW - Brain KW - Cognitive ability KW - Hippocampus KW - Learning KW - Long-term potentiation KW - Memory KW - Mobility KW - Neonates KW - Plasticity (synaptic) KW - Reversal learning KW - Spatial discrimination learning KW - Sucrose KW - citalopram KW - clomipramine KW - monoamines KW - spatial memory KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25110:Biochemical & Neurophysiological Correlates, Lesions and Stimuli UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904467887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Chronic+escitalopram+treatment+restores+spatial+learning%2C+monoamine+levels%2C+and+hippocampal+long-term+potentiation+in+an+animal+model+of+depression&rft.au=Bhagya%2C+V%3BSrikumar%2C+B+N%3BRaju%2C+T+R%3BRao%2C+Shankaranarayana%2C+BS&rft.aulast=Bhagya&rft.aufirst=V&rft.date=2011-03-01&rft.volume=214&rft.issue=2&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-010-2054-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-11-20 N1 - SubjectsTermNotLitGenreText - Biogenic amines; citalopram; Learning; monoamines; Mobility; Acetylcholinesterase; Hippocampus; Brain; Animal models; clomipramine; Plasticity (synaptic); spatial memory; Antidepressants; Memory; Reversal learning; Cognitive ability; Sucrose; Long-term potentiation; Neonates; Spatial discrimination learning DO - http://dx.doi.org/10.1007/s00213-010-2054-x ER - TY - JOUR T1 - PUGSVM: a caBIGTM analytical tool for multiclass gene selection and predictive classification AN - 904467309; 14386791 AB - SUMMARY: Phenotypic Up-regulated Gene Support Vector Machine (PUGSVM) is a cancer Biomedical Informatics Grid (caBIGTM) analytical tool for multiclass gene selection and classification. PUGSVM addresses the problem of imbalanced class separability, small sample size and high gene space dimensionality, where multiclass gene markers are defined by the union of one-versus-everyone phenotypic upregulated genes, and used by a well-matched one-versus-rest support vector machine. PUGSVM provides a simple yet more accurate strategy to identify statistically reproducible mechanistic marker genes for characterization of heterogeneous diseases. JF - Bioinformatics AU - Yu, Guoqiang AU - Li, Huai AU - Ha, Sook AU - Shih, Ie-Ming AU - Clarke, Robert AU - Hoffman, Eric P AU - Madhavan, Subha AU - Xuan, Jianhua AU - Wang, Yue AD - Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, Bioinformatics Unit, RRB, National Institute on Aging, NIH, Baltimore, MD 21224, Department of Gynecology and Obstetrics, Department of Pathology and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057 and Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA Y1 - 2011/03/01/ PY - 2011 DA - 2011 Mar 01 SP - 736 EP - 738 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 27 IS - 5 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Bioinformatics KW - Internet KW - Cancer KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904467309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=PUGSVM%3A+a+caBIGTM+analytical+tool+for+multiclass+gene+selection+and+predictive+classification&rft.au=Yu%2C+Guoqiang%3BLi%2C+Huai%3BHa%2C+Sook%3BShih%2C+Ie-Ming%3BClarke%2C+Robert%3BHoffman%2C+Eric+P%3BMadhavan%2C+Subha%3BXuan%2C+Jianhua%3BWang%2C+Yue&rft.aulast=Yu&rft.aufirst=Guoqiang&rft.date=2011-03-01&rft.volume=27&rft.issue=5&rft.spage=736&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Data processing; Bioinformatics; Cancer; Internet ER - TY - JOUR T1 - Assortment and packaging of the segmented rotavirus genome AN - 902354934; 14563448 AB - The rotavirus (RV) genome comprises 11 segments of double-stranded RNA (dsRNA) and is contained within a non-enveloped, icosahedral particle. During assembly, a highly coordinated selective packaging mechanism ensures that progeny RV virions contain one of each genome segment. Cis-acting signals thought to mediate assortment and packaging are associated with putative panhandle structures formed by base-pairing of the ends of RV plus-strand RNAs (+RNAs). Viral polymerases within assembling core particles convert the 11 distinct +RNAs to dsRNA genome segments. It remains unclear whether RV +RNAs are assorted before or during encapsidation, and the functions of viral proteins during these processes are not resolved. However, as reviewed here, recent insights gained from the study of RV and two other segmented RNA viruses, influenza A virus and bacteriophage I[brvbar]6, reveal potential mechanisms of RV assortment and packaging. JF - Trends in Microbiology AU - McDonald, Sarah M AU - Patton, John T AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8026, USA, jpatton@niaid.nih.gov PY - 2011 SP - 136 EP - 144 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 19 IS - 3 SN - 0966-842X, 0966-842X KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Rotavirus KW - Genomes KW - Virions KW - Phages KW - Double-stranded RNA KW - Core particles KW - Encapsidation KW - RNA viruses KW - Influenza A virus KW - Reviews KW - Progeny KW - Packaging KW - V 22320:Replication KW - G 07760:Viruses & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902354934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Microbiology&rft.atitle=Assortment+and+packaging+of+the+segmented+rotavirus+genome&rft.au=McDonald%2C+Sarah+M%3BPatton%2C+John+T&rft.aulast=McDonald&rft.aufirst=Sarah&rft.date=2011-03-01&rft.volume=19&rft.issue=3&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=Trends+in+Microbiology&rft.issn=0966842X&rft_id=info:doi/10.1016%2Fj.tim.2010.12.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-01-06 N1 - SubjectsTermNotLitGenreText - Phages; Virions; Genomes; Core particles; Reviews; Double-stranded RNA; Encapsidation; RNA viruses; Progeny; Packaging; Rotavirus; Influenza A virus DO - http://dx.doi.org/10.1016/j.tim.2010.12.002 ER - TY - JOUR T1 - Microfabricated high-moment micrometer-sized MRI contrast agents AN - 883015680; 15255912 AB - While chemically synthesized superparamagnetic microparticles have enabled much new research based on MRI tracking of magnetically labeled cells, signal-to-noise levels still limit the potential range of applications. Here it is shown how, through top-down microfabrication, contrast agent relaxivity can be increased several-fold, which should extend the sensitivity of such cell-tracking studies. Microfabricated agents can benefit from both higher magnetic moments and higher uniformity than their chemically synthesized counterparts, implying increased label visibility and more quantitative image analyses. To assess the performance of microfabricated micrometer-sized contrast agent particles, analytic models and numerical simulations are developed and tested against new microfabricated agents described in this article, as well as against results of previous imaging studies of traditional chemically synthesized microparticle agents. Experimental data showing signal effects of 500-nm thick, 2- Delta *mm diameter, gold-coated iron and gold-coated nickel disks verify the simulations. Additionally, it is suggested that measures of location better than the pixel resolution can be obtained and that these are aided using well-defined contrast agent particles achievable through microfabrication techniques. Magn Reson Med, 2011. [copy 2010 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Zabow, Gary AU - Dodd, Stephen J AU - Shapiro, Erik AU - Moreland, John AU - Koretsky, Alan P AD - Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA, zabowg@ninds.nih.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 645 EP - 655 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 65 IS - 3 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Mathematical models KW - microparticles KW - Magnetic resonance imaging KW - Nickel KW - Contrast media KW - Image processing KW - N.M.R. KW - Iron KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883015680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Microfabricated+high-moment+micrometer-sized+MRI+contrast+agents&rft.au=Zabow%2C+Gary%3BDodd%2C+Stephen+J%3BShapiro%2C+Erik%3BMoreland%2C+John%3BKoretsky%2C+Alan+P&rft.aulast=Zabow&rft.aufirst=Gary&rft.date=2011-03-01&rft.volume=169&rft.issue=suppl_11&rft.spage=S1&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwp124 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22647/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mathematical models; Data processing; microparticles; Nickel; Magnetic resonance imaging; Contrast media; Image processing; N.M.R.; Iron DO - http://dx.doi.org/10.1002/mrm.22647 ER - TY - JOUR T1 - Behavior and food consumption pattern of the population exposed in 1949-1962 to fallout from Semipalatinsk nuclear test site in Kazakhstan AN - 879472557; 14379354 AB - The relationship between radiation exposure from nuclear weapons testing fallout and thyroid disease in a group of 2,994 subjects has been the subject of study by the US National Cancer Institute. In that study, radiation doses to the thyroid were estimated for residents of villages in Kazakhstan possibly exposed to deposition of radioactive fallout from nuclear testing conducted by the Soviet Union at the Semipalatinsk Nuclear Test Site in Kazakhstan between 1949 and 1962. The study subjects included individuals of both Kazakh and Russian origin who were exposed during childhood and adolescence. An initial dose reconstruction used for the risk analysis of Land et al. (Radiat Res 169:373-383, 2008) was based on individual information collected from basic questionnaires administered to the study population in 1998. However, because data on several key questions for accurately estimating doses were not obtained from the 1998 questionnaires, it was decided to conduct a second data collection campaign in 2007. Due to the many years elapsed since exposure, a well-developed strategy was necessary to encourage accurate memory recall. In our recent study, a focus group interview data collection methodology was used to collect historical behavioral and food consumption data. The data collection in 2007 involved interviews conducted within four-eight-person focus groups (three groups of women and one group of men) in each of four exposed villages where thyroid disease screening was conducted in 1998. Population-based data on relevant childhood behaviors including time spent in- and outdoors and consumption rates of milk and other dairy products were collected from women's groups. The data were collected for five age groups of children and adolescents ranging from less than 1year of age to 21years of age. Dairy products considered included fresh milk and other products from cows, goats, mares, and sheep. Men's focus group interviews pertained to construction materials of houses and schools, and animal grazing patterns and feeding practices. The response data collected are useful for improving estimates of thyroid radiation dose estimates for the subjects of an ongoing epidemiological study. JF - Radiation and Environmental Biophysics AU - Drozdovitch, Vladimir AU - Schonfeld, Sara AU - Akimzhanov, Kuat AU - Aldyngurov, Daulet AU - Land, Charles E AU - Luckyanov, Nickolas AU - Mabuchi, Kiyohiko AU - Potischman, Nancy AU - Schwerin, Michael J AU - Semenova, Yulia AU - Tokaeva, Alma AU - Zhumadilov, Zhaxybay AU - Bouville, Andre AU - Simon, Steven L AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Bethesda, MD, 20892-7238, USA, drozdovv@mail.nih.gov drozdovv@mail.nih.gov drozdovv@mail.nih.gov drozdovv@mail.nih.gov drozdovv@mail.nih.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 91 EP - 103 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany VL - 50 IS - 1 SN - 0301-634X, 0301-634X KW - Risk Abstracts; Pollution Abstracts KW - Data collection KW - Age KW - Risk analysis KW - Milk KW - Thyroid KW - Dairy products KW - Residential areas KW - Kazakhstan KW - villages KW - Cancer KW - R2 23060:Medical and environmental health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879472557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+and+Environmental+Biophysics&rft.atitle=Behavior+and+food+consumption+pattern+of+the+population+exposed+in+1949-1962+to+fallout+from+Semipalatinsk+nuclear+test+site+in+Kazakhstan&rft.au=Drozdovitch%2C+Vladimir%3BSchonfeld%2C+Sara%3BAkimzhanov%2C+Kuat%3BAldyngurov%2C+Daulet%3BLand%2C+Charles+E%3BLuckyanov%2C+Nickolas%3BMabuchi%2C+Kiyohiko%3BPotischman%2C+Nancy%3BSchwerin%2C+Michael+J%3BSemenova%2C+Yulia%3BTokaeva%2C+Alma%3BZhumadilov%2C+Zhaxybay%3BBouville%2C+Andre%3BSimon%2C+Steven+L&rft.aulast=Drozdovitch&rft.aufirst=Vladimir&rft.date=2011-03-01&rft.volume=50&rft.issue=1&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Radiation+and+Environmental+Biophysics&rft.issn=0301634X&rft_id=info:doi/10.1007%2Fs00411-010-0334-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2015-05-27 N1 - SubjectsTermNotLitGenreText - Risk analysis; Age; Data collection; Milk; Residential areas; Dairy products; Thyroid; villages; Cancer; Kazakhstan DO - http://dx.doi.org/10.1007/s00411-010-0334-9 ER - TY - JOUR T1 - A Case-Control Investigation of Adenomyosis: Impact of Control Group Selection on Risk Factor Strength AN - 875712931; 201113531 AB - Objective: Using a medical record abstraction-based case-control study with two control groups, we evaluated adenomyosis risk factors and investigated differences related to comparison group selection. Materials and Methods: Medical records of all female 18- to 49-year-old Group Health (GH) enrollees with ICD-9 code 617.0 were abstracted using a standard data collection form. Cases were enrollees diagnosed with adenomyosis (n = 174) between April 1996 and September 2001. For comparison, medical records of two control groups were selected from the GH population: An age-matched sample of female enrollees (population-based controls; n = 149) and all female 18- to 49-year-old enrollees undergoing a hysterectomy (hysterectomy controls; n = 106) during the same time without adenomyosis. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using logistic regression, adjusted for identified covariates. Results: Compared with normal and underweight women, overweight and obese women had increased adenomyosis risk using hysterectomy controls (OR, 2.2, 95% CI, 1.0-4.5; obese: OR, 2.2; 95% CI, 1.1-4.3) and population controls (overweight: OR, 2.1; 95% CI, 1.2-4.0; obese: OR, 3.8; 95% CI, 2.0-7.0). Using population controls, women with at least one live birth were more likely to have adenomyosis than nulliparous women (OR, 3.4; 95% CI, 1.9-6.2). Conclusion: Although some risk factors persisted in analyses using either control group, divergent results in relation to other risk factors for adenomyosis suggest that results of investigations of this disease may be affected by the choice of the comparison population. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Trabert, Britton AU - Weiss, Noel S AU - Rudra, Carole B AU - Scholes, Delia AU - Holt, Victoria L AD - 6120 Executive Blvd. EPS Suite 500/ Room 5006, Rockville. MD 20852, Tel: (301)451-4435, Fax: (301)402-0916 E-mail: trabertb1@mail.nih.gov Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 160 EP - 164 PB - Elsevier Science, New York NY VL - 21 IS - 2 SN - 1049-3867, 1049-3867 KW - Obesity KW - Population control KW - Hysterectomy KW - Medical records KW - Risk factors KW - Women KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875712931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=A+Case-Control+Investigation+of+Adenomyosis%3A+Impact+of+Control+Group+Selection+on+Risk+Factor+Strength&rft.au=Trabert%2C+Britton%3BWeiss%2C+Noel+S%3BRudra%2C+Carole+B%3BScholes%2C+Delia%3BHolt%2C+Victoria+L&rft.aulast=Trabert&rft.aufirst=Britton&rft.date=2011-03-01&rft.volume=21&rft.issue=2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2010.09.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-07-07 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Risk factors; Obesity; Hysterectomy; Medical records; Women; Population control DO - http://dx.doi.org/10.1016/j.whi.2010.09.005 ER - TY - JOUR T1 - Mutational analysis of conserved aspartic acid residues in the Methanothermobacter thermautotrophicus MCM helicase AN - 872137195; 14435899 AB - Minichromosome maintenance (MCM) helicases are thought to function as the replicative helicases in archaea and eukarya, unwinding the duplex DNA in the front of the replication fork. The archaeal MCM helicase can be divided into three parts, the N-terminal, catalytic, and C-terminal regions. The N-terminal part of the protein is divided into three domains, A, B, and C, and was shown to be involved in protein multimerization and binding to single- and double-stranded DNA. Two Asp residues found in domain C are conserved among MCM proteins from different archaea. These residues are located in a loop at the interface with domain A. Mutations of these residues in the Methanothermobacter thermautotrophicus MCM protein, Asp202 and Asp203, to Asn result in a significant reduction in the ability of the enzyme to bind DNA and in lower thermal stability. However, the mutant proteins retained helicase and ATPase activities. Further investigation of the DNA binding revealed that the presence of ATP rescues the DNA binding deficiencies by these mutant proteins. Possible roles of these conserved residues in MCM function are discussed. JF - Extremophiles AU - Sakakibara, Nozomi AU - Kasiviswanathan, Rajesh AU - Kelman, Zvi AD - Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, MD, 20850, USA, sakakibaran@niaid.nih.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 245 EP - 252 PB - Springer-Verlag, 3-13 Hongo 3-chrome, Bunkyo-ku Tokyo 113-0033 Japan VL - 15 IS - 2 SN - 1431-0651, 1431-0651 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Adenosinetriphosphatase KW - Aspartic acid KW - Archaea KW - Unwinding KW - ATP KW - Enzymes KW - MCM protein KW - Replication forks KW - DNA KW - Thermal stability KW - DNA helicase KW - Mutation KW - J 02310:Genetics & Taxonomy KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872137195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Extremophiles&rft.atitle=Mutational+analysis+of+conserved+aspartic+acid+residues+in+the+Methanothermobacter+thermautotrophicus+MCM+helicase&rft.au=Sakakibara%2C+Nozomi%3BKasiviswanathan%2C+Rajesh%3BKelman%2C+Zvi&rft.aulast=Sakakibara&rft.aufirst=Nozomi&rft.date=2011-03-01&rft.volume=15&rft.issue=2&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Extremophiles&rft.issn=14310651&rft_id=info:doi/10.1007%2Fs00792-010-0352-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Aspartic acid; Adenosinetriphosphatase; Replication forks; Unwinding; DNA; Enzymes; ATP; Thermal stability; Mutation; DNA helicase; MCM protein; Archaea DO - http://dx.doi.org/10.1007/s00792-010-0352-1 ER - TY - JOUR T1 - Subtyping Male Perpetrators of Intimate Partner Violence AN - 871000311; 201102704 AB - Domestic violence is a serious problem with far-reaching consequences. This study applies a new methodology to derive subtypes of male perpetrators of intimate partner violence. As part of a larger National Institute of Mental Health (NIMH)-funded study, a national sample of randomly selected psychologists and psychiatrists describe 188 adult male patients (59 with a history of partner violence, 97 with a history of arrests but not partner violence, and 57 with neither partner violence nor arrests), using the Shedler-Westen Assessment Procedure-II (SWAP-II), a Q-sort procedure for assessing personality pathology. Using Q-factor analysis, the authors identify three personality constellations among the partner-violent men, two of which strongly resembled subtypes identified using different methods in prior research: psychopathic, hostile/controlling, and borderline/dependent The authors compare these subtypes with each other and with nonarrested/nonviolent men and men with arrests but no partner violence on Axis I and II diagnoses, adaptive functioning, etiological variables, and response to treatment, providing initial validity data. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Journal of Interpersonal Violence AU - Fowler, Katherine A AU - Westen, Drew AD - National Institute of Mental Health, 15K North Drive, Bldg 15K, Rm. 300-CMSC 2670, Bethesda, MD 20892-2670 E-mail: fowlerka@mail.nih.gov Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 607 EP - 639 PB - Sage Publications, Thousand Oaks CA VL - 26 IS - 4 SN - 0886-2605, 0886-2605 KW - intimate violence, personality, SWAP-II, subtyping, Q-factor analysis, domestic violence, cluster analysis KW - Partner Abuse KW - Males KW - Psychologists KW - Personality KW - Family Violence KW - Patients KW - Arrests KW - Psychopathology KW - Psychiatrists KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/871000311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interpersonal+Violence&rft.atitle=Subtyping+Male+Perpetrators+of+Intimate+Partner+Violence&rft.au=Fowler%2C+Katherine+A%3BWesten%2C+Drew&rft.aulast=Fowler&rft.aufirst=Katherine&rft.date=2011-03-01&rft.volume=26&rft.issue=4&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interpersonal+Violence&rft.issn=08862605&rft_id=info:doi/10.1177%2F0886260510365853 LA - English DB - Social Services Abstracts N1 - Date revised - 2011-08-04 N1 - Last updated - 2016-09-28 N1 - CODEN - JIVIEI N1 - SubjectsTermNotLitGenreText - Males; Partner Abuse; Family Violence; Personality; Psychiatrists; Psychopathology; Psychologists; Arrests; Patients DO - http://dx.doi.org/10.1177/0886260510365853 ER - TY - JOUR T1 - Regional brain activation/deactivation during word generation in schizophrenia: fMRI study AN - 870996016; 201112328 AB - Background Examination of the brain regions that show aberrant activations and/or deactivations during semantic word generation could pave the way for a better understanding of the neurobiology of cognitive dysfunction in schizophrenia. Aims To examine the pattern of functional magnetic resonance imaging blood oxygen level dependent activations and deactivations during semantic word generation in schizophrenia. healthy individuals were replicated with minimal redundancies in participants with schizophrenia. Method Functional magnetic resonance imaging was performed on 24 participants with schizophrenia and 24 matched healthy controls during an overt, paced, 'semantic category word generation' condition and a baseline 'word repetition' condition that modelled all the lead-in/associated processes involved in the performance of the generation task. Results The brain regions activated during word generation in healthy individuals were replicated with minimal redundancies in participants with schizophrenia. The individuals with schizophrenia showed additional activations of temporo-parieto-occipital cortical regions as well as subcortical regions, despite significantly poorer behavioural performance than the healthy participants. Importantly, the extensive deactivations in other brain regions during word generation in healthy individuals could not be replicated in those with schizophrenia. Conclusions More widespread activations and deficient deactivations in the poorly performing participants with schizophrenia may reflect an inability to inhibit competing cognitive processes, which in turn could constitute the core information-processing deficit underlying impaired word generation in schizophrenia. Declaration of Interest None. Adapted from the source document. JF - The British Journal of Psychiatry AU - John, John P AU - Halahalli, Harsha N AU - Vasudev, Mandapati K AU - Jayakumar, Peruvumba N AU - Jain, Sanjeev AD - National Institute of Mental Health and Neurosciences (NIMHANS), Post Box Number 2900, Dharmaram Post Office, Hosur Road, Bangalore, 560 029, Karnataka, India E-mail: jpj@nimhans.kar.nic.in Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 213 EP - 222 PB - Royal College of Psychiatrists, London UK VL - 198 IS - 3 SN - 0007-1250, 0007-1250 KW - Schizophrenia KW - Cognitive processes KW - Functional magnetic resonance imaging KW - Brain KW - Redundancy KW - Dysfunction KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/870996016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+Journal+of+Psychiatry&rft.atitle=Regional+brain+activation%2Fdeactivation+during+word+generation+in+schizophrenia%3A+fMRI+study&rft.au=John%2C+John+P%3BHalahalli%2C+Harsha+N%3BVasudev%2C+Mandapati+K%3BJayakumar%2C+Peruvumba+N%3BJain%2C+Sanjeev&rft.aulast=John&rft.aufirst=John&rft.date=2011-03-01&rft.volume=198&rft.issue=3&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Psychiatry&rft.issn=00071250&rft_id=info:doi/10.1192%2Fbjp.bp.110.083501 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-06-07 N1 - Last updated - 2016-09-27 N1 - CODEN - BJPYAJ N1 - SubjectsTermNotLitGenreText - Schizophrenia; Brain; Redundancy; Functional magnetic resonance imaging; Dysfunction; Cognitive processes DO - http://dx.doi.org/10.1192/bjp.bp.110.083501 ER - TY - JOUR T1 - Employing immersive virtual environments for innovative experiments in health care communication AN - 870995197; 201112515 AB - Objective: This report reviews the literature for studies that employ immersive virtual environment technology methods to conduct experimental studies in health care communication. Advantages and challenges of using these tools for research in this area are also discussed. Methods: A literature search was conducted using the Scopus database. Results were hand searched to identify the body of studies, conducted since 1995, that are related to the report objective. Results: The review identified four relevant studies that stem from two unique projects. One project focused on the impact of a clinician's characteristics and behavior on health care communication, the other focused on the characteristics of the patient. Both projects illustrate key methodological advantages conferred by immersive virtual environments, including, ability to maintain simultaneously high experimental control and realism, ability to manipulate variables in new ways, and unique behavioral measurement opportunities. Conclusion: Though implementation challenges exist for immersive virtual environment-based research methods, given the technology's unique capabilities, benefits can outweigh the costs in many instances. Practice implications: Immersive virtual environments may therefore prove an important addition to the array of tools available for advancing our understanding of communication in health care. [Copyright Elsevier B.V.] JF - Patient Education and Counseling AU - Persky, Susan AD - Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, MD, USA perskys@mail.nih.gov Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 313 EP - 317 PB - Elsevier Ltd, The Netherlands VL - 82 IS - 3 SN - 0738-3991, 0738-3991 KW - Communication Health care Virtual environments Virtual reality Methods KW - Databases KW - Measurement KW - Health costs KW - Research methods KW - Health care KW - Technology KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/870995197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Patient+Education+and+Counseling&rft.atitle=Employing+immersive+virtual+environments+for+innovative+experiments+in+health+care+communication&rft.au=Persky%2C+Susan&rft.aulast=Persky&rft.aufirst=Susan&rft.date=2011-03-01&rft.volume=82&rft.issue=3&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Patient+Education+and+Counseling&rft.issn=07383991&rft_id=info:doi/10.1016%2Fj.pec.2010.12.007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-06-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Health care; Technology; Health costs; Measurement; Research methods; Databases DO - http://dx.doi.org/10.1016/j.pec.2010.12.007 ER - TY - JOUR T1 - SOT at 50: A Proud Legacy, A Vibrant Future AN - 869834013; 14606811 AB - Abstract not available. JF - Environmental Health Perspectives AU - Birnbaum, Linda S AD - Director, NIEHS and NTP, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, birnbaumls@niehs.nih.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - A110 EP - A111 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 119 IS - 3 SN - 0091-6765, 0091-6765 KW - Environment Abstracts KW - Environmental health KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869834013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=SOT+at+50%3A+A+Proud+Legacy%2C+A+Vibrant+Future&rft.au=Birnbaum%2C+Linda+S&rft.aulast=Birnbaum&rft.aufirst=Linda&rft.date=2011-03-01&rft.volume=119&rft.issue=3&rft.spage=A110&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1103511 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Environmental health DO - http://dx.doi.org/10.1289/ehp.1103511 ER - TY - JOUR T1 - Germ cell formation from embryonic stem cells and the use of somatic cell nuclei in oocytes AN - 869801704; 14521157 AB - Embryonic stem cells (ESCs) have remarkable properties of pluripotency and self-renewal, along with the retention of chromosomal integrity. Germ cells function as a kind of "transgenerational stem cells," transmitting genetic information from one generation to the next. The formation of putative primordial germ cells (PGCs) and germ cells from mouse and human ESCs (hESCs) has, in fact, been shown, and the apparent derivation of functional mouse male gametes has also been described. Additionally, investigators have successfully reprogrammed somatic nuclei into a pluripotent state by inserting them into ESCs or oocytes. This would enable the generation of ESCs genetically identical to the somatic cell donor and their use in cell therapy. However, these methodologies are still inefficient and their mechanisms poorly understood. Until full comprehension of these processes is obtained, clinical applications remain remote. Nevertheless, they represent promising tools in the future, enhancing methods of therapeutic cloning and infertility treatment. JF - Annals of the New York Academy of Sciences AU - Pelosi, Emanuele AU - Forabosco, Antonino AU - Schlessinger, David AD - Laboratory of Genetics, National Institute on Aging/NIH Intramural Research Program, Baltimore, Maryland. Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 18 EP - 26 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 1221 IS - 1 SN - 0077-8923, 0077-8923 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Infertility KW - Stem cells KW - Embryo cells KW - Gametes KW - Germ cells KW - Cloning KW - Oocytes KW - Therapeutic applications KW - Somatic cells KW - Nuclei KW - W 30925:Genetic Engineering KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869801704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Germ+cell+formation+from+embryonic+stem+cells+and+the+use+of+somatic+cell+nuclei+in+oocytes&rft.au=Pelosi%2C+Emanuele%3BForabosco%2C+Antonino%3BSchlessinger%2C+David&rft.aulast=Pelosi&rft.aufirst=Emanuele&rft.date=2011-03-01&rft.volume=1221&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1111%2Fj.1749-6632.2011.05982.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Document feature - figure 2 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Infertility; Stem cells; Gametes; Embryo cells; Cloning; Germ cells; Therapeutic applications; Oocytes; Nuclei; Somatic cells DO - http://dx.doi.org/10.1111/j.1749-6632.2011.05982.x ER - TY - JOUR T1 - Iron deficiency in blood donors: analysis of enrollment data from the REDS-II Donor Iron Status Evaluation (RISE) study AN - 869581765; 14521768 AB - BACKGROUND: Regular blood donors are at risk of iron deficiency, but characteristics that predispose to this condition are poorly defined. STUDY DESIGN AND METHODS: A total of 2425 red blood cell donors, either first-time (FT) or reactivated donors (no donations for 2 years) or frequent donors, were recruited for follow-up. At enrollment, ferritin, soluble transferrin receptor (sTfR), and hemoglobin were determined. Donor variables included demographics, smoking, dietary intake, use of iron supplements, and menstrual and/or pregnancy history. Models to predict two measures of iron deficiency were developed: Absent iron stores (AIS) were indicated by a ferritin level of less than 12ng/mL and iron-deficient erythropoiesis (IDE) by a log(sTfR/ferritin) value of 2.07 or greater. RESULTS: A total of 15.0% of donors had AIS and 41.7% IDE. In frequent donors, 16.4 and 48.7% of males had AIS and IDE, respectively, with corresponding proportions of 27.1 and 66.1% for females. Donation intensity was most closely associated with AIS and/or IDE (odds ratios from 5.3 to 52.2 for different donation intensity compared to FT donors). Being female, younger, and/or menstruating also increased the likelihood of having AIS and/or IDE, as did having a lower weight. Marginally significant variables for AIS and/or IDE were being a nonsmoker, previous pregnancy, and not taking iron supplements. Dietary variables were in general unrelated to AIS and/or IDE, as was race and/or ethnicity. CONCLUSION: A large proportion of both female and male frequent blood donors have iron depletion. Donation intensity, sex and/or menstrual status, weight, and age are important independent predictors of AIS and/or IDE. Reducing the frequency of blood donation is likely to reduce the prevalence of iron deficiency among blood donors, as might implementing routine iron supplementation. JF - Transfusion AU - Cable, Ritchard G AU - Glynn, Simone A AU - Kiss, Joseph E AU - Mast, Alan E AU - Steele, Whitney R AU - Murphy, Edward L AU - Wright, David J AU - Sacher, Ronald A AU - Gottschall, Jerry L AU - Vij, Vibha AU - Simon, Toby L AD - From the New England Region, American Red Cross Blood Services, Farmington, Connecticut; Transfusion Medicine and Cellular Therapies, National Heart, Lung, and Blood Institute, Bethesda, Maryland; the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania; the Blood Center of Wisconsin, Milwaukee, Wisconsin; the Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin; Westat, Rockville, Maryland; the University of California at San Francisco and Blood Systems Research Institute, San Francisco, California; the Hoxworth Blood Center, University of Cincinnati Academic Health Center, Cincinnati, Ohio; and CSL Plasma, Boca Raton, Florida. Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 511 EP - 522 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 51 IS - 3 SN - 0041-1132, 0041-1132 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - Diets KW - Ethnic groups KW - Historical account KW - Ingestion KW - Iron KW - Pregnancy KW - blood donors KW - demography KW - H 13000:Medical Safety KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869581765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Iron+deficiency+in+blood+donors%3A+analysis+of+enrollment+data+from+the+REDS-II+Donor+Iron+Status+Evaluation+%28RISE%29+study&rft.au=Cable%2C+Ritchard+G%3BGlynn%2C+Simone+A%3BKiss%2C+Joseph+E%3BMast%2C+Alan+E%3BSteele%2C+Whitney+R%3BMurphy%2C+Edward+L%3BWright%2C+David+J%3BSacher%2C+Ronald+A%3BGottschall%2C+Jerry+L%3BVij%2C+Vibha%3BSimon%2C+Toby+L&rft.aulast=Cable&rft.aufirst=Ritchard&rft.date=2011-03-01&rft.volume=51&rft.issue=3&rft.spage=511&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2010.02865.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Document feature - figure 2 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - demography; Diets; Historical account; Age; blood donors; Ingestion; Iron; Ethnic groups; Pregnancy DO - http://dx.doi.org/10.1111/j.1537-2995.2010.02865.x ER - TY - JOUR T1 - Absence of detectable xenotropic murine leukemia virus-related virus in plasma or peripheral blood mononuclear cells of human immunodeficiency virus Type 1-infected blood donors or individuals in Africa AN - 869571433; 14521747 AB - BACKGROUND: Since the identification of xenotropic murine leukemia virus-related virus (XMRV) in prostate cancer patients in 2006 and in chronic fatigue syndrome patients in 2009, conflicting findings have been reported regarding its etiologic role in human diseases and prevalence in general populations. In this study, we screened both plasma and peripheral blood mononuclear cells (PBMNCs) collected in Africa from blood donors and human immunodeficiency virus Type 1 (HIV-1)-infected individuals to gain evidence of XMRV infection in this geographic region. STUDY DESIGN AND METHODS: A total of 199 plasma samples, 19 PBMNC samples, and 50 culture supernatants from PBMNCs of blood donors from Cameroon found to be infected with HIV-1 and HIV-1 patients from Uganda were screened for XMRV infection using a sensitive nested polymerase chain reaction (PCR) or reverse transcription (RT)-PCR assay. RESULTS: Using highly sensitive nested PCR or RT-PCR and real-time PCR assays capable of detecting at least 10 copies of XMRV plasmid DNA per reaction, none of the 268 samples tested were found to be XMRV DNA or RNA positive. CONCLUSIONS: Our results failed to demonstrate the presence of XMRV infection in African blood donors or individuals infected with HIV-1. More studies are needed to understand the prevalence, epidemiology, and geographic distribution of XMRV infection worldwide. JF - Transfusion AU - Tang, Shixing AU - Zhao, Jiangqin AU - Viswanath, Ragupathy AU - Nyambi, Phillipe N AU - Redd, Andrew D AU - Dastyar, Armeta AU - Spacek, Lisa A AU - Quinn, Thomas C AU - Wang, Xue AU - Wood, Owen AU - Gaddam, Durga AU - Devadas, Krishnakumar AU - Hewlett, Indira K AD - From the Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland; the Department of Pathology, New York University School of Medicine, New York, New York; and the Division of Intramural Research, NIAID, NIH, Johns Hopkins University School of Medicine, Baltimore, Maryland. Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 463 EP - 468 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 51 IS - 3 SN - 0041-1132, 0041-1132 KW - Immunology Abstracts; Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Blood donors KW - Cell culture KW - Epidemiology KW - Geographical distribution KW - Leukemia KW - Peripheral blood mononuclear cells KW - Plasmids KW - Polymerase chain reaction KW - Prostate cancer KW - RNA KW - Reverse transcription KW - Xenotropic KW - blood donors KW - chronic fatigue syndrome KW - Human immunodeficiency virus KW - Human immunodeficiency virus 1 KW - Africa KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22360:AIDS and HIV KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869571433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Absence+of+detectable+xenotropic+murine+leukemia+virus-related+virus+in+plasma+or+peripheral+blood+mononuclear+cells+of+human+immunodeficiency+virus+Type+1-infected+blood+donors+or+individuals+in+Africa&rft.au=Tang%2C+Shixing%3BZhao%2C+Jiangqin%3BViswanath%2C+Ragupathy%3BNyambi%2C+Phillipe+N%3BRedd%2C+Andrew+D%3BDastyar%2C+Armeta%3BSpacek%2C+Lisa+A%3BQuinn%2C+Thomas+C%3BWang%2C+Xue%3BWood%2C+Owen%3BGaddam%2C+Durga%3BDevadas%2C+Krishnakumar%3BHewlett%2C+Indira+K&rft.aulast=Tang&rft.aufirst=Shixing&rft.date=2011-03-01&rft.volume=51&rft.issue=3&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2010.02932.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Document feature - figure 2 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Blood donors; Geographical distribution; Peripheral blood mononuclear cells; Prostate cancer; RNA; Epidemiology; Polymerase chain reaction; Cell culture; chronic fatigue syndrome; Plasmids; Xenotropic; Reverse transcription; Leukemia; blood donors; Human immunodeficiency virus; Human immunodeficiency virus 1; Africa DO - http://dx.doi.org/10.1111/j.1537-2995.2010.02932.x ER - TY - JOUR T1 - Deliberation to enhance awareness of and prioritize socioeconomic interventions for health AN - 868018191; 201113941 AB - Health disparities are, to a large extent, the result of socio-economic factors that cannot be entirely mitigated through the health care system. While an array of social services are thought to be necessary to address the social determinants of health, budget constraints, particularly in difficult economic times, limit the availability of such services. It is therefore necessary to prioritize interventions through some fair process. While it might be appropriate to engage in public deliberation to set priorities, doing so requires that the public accept such a deliberative process and appreciate the social determinants of health. We therefore analyzed the results of a study in which groups deliberated to prioritize socio-economic interventions to examine whether these two requirements can possibly be met and to explore the basis for their priorities. A total of 431 residents of Washington, D.C. with incomes under 200% of the federal poverty threshold participated in 43 groups to engage in a hypothetical exercise to prioritize interventions designed to ameliorate the social determinants of health within the constraints of a limited budget. Findings from pre- and post-exercise questionnaires demonstrate that the priority setting exercise was perceived as a fair deliberative process, and that following the deliberation, participants became more likely to agree that a broad number of determinants contribute to their health. Qualitative analysis of the group discussions indicate that participants prioritized interventions that would provide for basic necessities and improve community conditions, while at the same time addressing more macro-structural factors such as homelessness and unemployment. We conclude that engaging small groups in deliberation about ways to address the social determinants of health can both change participant attitudes and yield informed priorities that might guide public policy aimed at most affordably reducing health disparities. Provides innovative approach to understanding public attitudes about socio-economic factors that influence health in the USA. Demonstrates the feasibility of informing low income populations about the social determinants of health. Provides information about the highest service priorities of low income urban residents. Indicates that public deliberation about the social determinants of health can yield informed priorities for public policy. [Copyright Elsevier Ltd.] JF - Social Science & Medicine AU - Pesce, Julianna E AU - Kpaduwa, Chinwe S AU - Danis, Marion AD - National Institutes of Health, Department of Clinical Bioethics, Building 10, Room 1C118, 10 Center Drive MSC 1156, Bethesda, MD 20892-1156, United States jpesce@mednet.ucla.edu Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 789 EP - 797 PB - Elsevier Science, Amsterdam The Netherlands VL - 72 IS - 5 SN - 0277-9536, 0277-9536 KW - USA Public participation Interventions Health priorities Health status disparities Public assistance Poverty Resource allocation KW - Socioeconomic Factors KW - Low Income Groups KW - Health Behavior KW - Intervention KW - Health KW - Urban Population KW - Homelessness KW - Equity KW - Health Care Services KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/868018191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Deliberation+to+enhance+awareness+of+and+prioritize+socioeconomic+interventions+for+health&rft.au=Pesce%2C+Julianna+E%3BKpaduwa%2C+Chinwe+S%3BDanis%2C+Marion&rft.aulast=Pesce&rft.aufirst=Julianna&rft.date=2011-03-01&rft.volume=72&rft.issue=5&rft.spage=789&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2011.01.002 LA - English DB - Sociological Abstracts N1 - Date revised - 2011-05-18 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Intervention; Health; Health Behavior; Health Care Services; Low Income Groups; Socioeconomic Factors; Equity; Homelessness; Urban Population DO - http://dx.doi.org/10.1016/j.socscimed.2011.01.002 ER - TY - JOUR T1 - A Qualitative Study On the Needs of Caregivers of Inpatients With Schizophrenia in India AN - 862591073; 201109815 AB - Aim: To explore the needs of caregivers of inpatients with schizophrenia in India. Material: Thirty caregivers of inpatients with schizophrenia participated in five focus group discussions (FGD), where the needs of the caregivers were discussed. The FGDs were recorded, transcribed and similar needs were grouped and ranked according to their order of importance. Discussion: The main needs that emerged were regarding: managing the behaviour of patients; managing social-vocational problems of patients; health issues of caregivers; education about schizophrenia; rehabilitation; and managing sexual and marital problems of patients. Conclusion: This study has identified additional needs of caregivers from those found in other studies. [Reprinted by permission of Sage Publications Ltd., copyright holder.] JF - International Journal of Social Psychiatry AU - Jagannathan, A AU - Thirthalli, J AU - Hamza, A AU - Hariprasad, V R AU - Nagendra, H R AU - Gangadhar, B N AD - Department of Psychiatric Social Work, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 180 EP - 194 PB - Sage Publications, London UK VL - 57 IS - 2 SN - 0020-7640, 0020-7640 KW - needs caregivers schizophrenia focus group discussion qualitative analysis KW - Schizophrenia KW - Rehabilitation KW - Hospitalization KW - Health KW - Marital problems KW - Carers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862591073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Social+Psychiatry&rft.atitle=A+Qualitative+Study+On+the+Needs+of+Caregivers+of+Inpatients+With+Schizophrenia+in+India&rft.au=Jagannathan%2C+A%3BThirthalli%2C+J%3BHamza%2C+A%3BHariprasad%2C+V+R%3BNagendra%2C+H+R%3BGangadhar%2C+B+N&rft.aulast=Jagannathan&rft.aufirst=A&rft.date=2011-03-01&rft.volume=57&rft.issue=2&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Social+Psychiatry&rft.issn=00207640&rft_id=info:doi/10.1177%2F0020764009347334 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-27 N1 - CODEN - IJSPAG N1 - SubjectsTermNotLitGenreText - Carers; Schizophrenia; Hospitalization; Marital problems; Rehabilitation; Health DO - http://dx.doi.org/10.1177/0020764009347334 ER - TY - JOUR T1 - Knowledge of and adherence to fruit and vegetable recommendations and intakes: results of the 2003 Health Information National Trends Survey AN - 861386543; 4180756 AB - Attention to cancer-relevant communication (e.g., fruit/vegetable intake recommendations) through various media has been shown to be a pivotal step in reduction of the cancer burden, thus underscoring the importance of examining associations between exposure to health media and knowledge of and adherence to fruit/vegetable intake recommendations. The purpose of the present study was to assess factors associated with fruit/vegetable intake knowledge and behavior. The authors analyzed data collected from the 2003 Health Information National Trends Survey to evaluate the effect of fruit/vegetable intake knowledge on behavior, and the relationship of this effect with biobehavioral, sociodemographic, and communication characteristics. Participants who were knowledgeable of fruit/vegetable intake recommendations and consumed at least 5 fruit/vegetable servings per day were classified as informed compliers. Associations were observed for being an informed complier and paying a lot of attention to health media on the radio, in the newspaper, and in magazines and a little or some attention to health media in magazines or on the Internet. The recent explosion of available cancer-related information through various media underscores the importance of examining associations between exposure to health media and knowledge of and adherence to fruit/vegetable intake recommendations. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Thompson, Olivia AU - Yaroch, Amy AU - Moser, Richard AU - Finney Rutten, Lila AU - Petrelli, Jennifer AU - Smith-Warner, Stephanie AU - Masse, Louise AU - Nebeling, Linda AD - University of Nebraska ; National Cancer Institute, U.S.A. ; Newton Center, Massachusetts ; Harvard University ; Centre for Community Child Health Research, Vancouver Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 328 EP - 340 VL - 16 IS - 3 SN - 1081-0730, 1081-0730 KW - Political Science KW - Press KW - Vegetables KW - Media KW - Health education KW - Surveys KW - Fruit KW - Access to information KW - Knowledge KW - Cancer KW - Health promotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/861386543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Knowledge+of+and+adherence+to+fruit+and+vegetable+recommendations+and+intakes%3A+results+of+the+2003+Health+Information+National+Trends+Survey&rft.au=Thompson%2C+Olivia%3BYaroch%2C+Amy%3BMoser%2C+Richard%3BFinney+Rutten%2C+Lila%3BPetrelli%2C+Jennifer%3BSmith-Warner%2C+Stephanie%3BMasse%2C+Louise%3BNebeling%2C+Linda&rft.aulast=Thompson&rft.aufirst=Olivia&rft.date=2011-03-01&rft.volume=16&rft.issue=3&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730.2010.532293 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1939 3617 6220; 5790 5772; 7862 2572; 7073; 5779 4049; 10063 7862 2572; 518 6515; 5326 5333 5136 10286; 12429; 13267 5333 5136 10286 DO - http://dx.doi.org/10.1080/10810730.2010.532293 ER - TY - JOUR T1 - Diffeomorphic Image Registration of Diffusion MRI Using Spherical Harmonics AN - 860394374; 14407091 AB - Nonrigid registration of diffusion magnetic resonance imaging (MRI) is crucial for group analyses and building white matter and fiber tract atlases. Most current diffusion MRI registration techniques are limited to the alignment of diffusion tensor imaging (DTI) data. We propose a novel diffeomorphic registration method for high angular resolution diffusion images by mapping their orientation distribution functions (ODFs). ODFs can be reconstructed using q-ball imaging (QBI) techniques and represented by spherical harmonics (SHs) to resolve intra-voxel fiber crossings. The registration is based on optimizing a diffeomorphic demons cost function. Unlike scalar images, deforming ODF maps requires ODF reorientation to maintain its consistency with the local fiber orientations. Our method simultaneously reorients the ODFs by computing a Wigner rotation matrix at each voxel, and applies it to the SH coefficients during registration. Rotation of the coefficients avoids the estimation of principal directions, which has no analytical solution and is time consuming. The proposed method was validated on both simulated and real data sets with various metrics, which include the distance between the estimated and simulated transformation fields, the standard deviation of the general fractional anisotropy and the directional consistency of the deformed and reference images. The registration performance using SHs with different maximum orders were compared using these metrics. Results show that the diffeomorphic registration improved the affine alignment, and registration using SHs with higher order SHs further improved the registration accuracy by reducing the shape difference and improving the directional consistency of the registered and reference ODF maps. JF - IEEE Transactions on Medical Imaging AU - Geng, Xiujuan AU - Ross, Thomas J AU - Gu, Hong AU - Shin, Wanyong AU - Zhan, Wang AU - Chao, Yi-Ping AU - Lin, Ching-Po AU - Schuff, Norbert AU - Yang, Yihong AD - Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD, USA Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 747 EP - 758 PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 USA VL - 30 IS - 3 SN - 0278-0062, 0278-0062 KW - Biotechnology and Bioengineering Abstracts KW - Transformation KW - Fibers KW - Standard deviation KW - Depth perception KW - Anisotropy KW - Atlases KW - Magnetic resonance imaging KW - Substantia alba KW - Diffusion KW - Mapping KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860394374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Medical+Imaging&rft.atitle=Diffeomorphic+Image+Registration+of+Diffusion+MRI+Using+Spherical+Harmonics&rft.au=Geng%2C+Xiujuan%3BRoss%2C+Thomas+J%3BGu%2C+Hong%3BShin%2C+Wanyong%3BZhan%2C+Wang%3BChao%2C+Yi-Ping%3BLin%2C+Ching-Po%3BSchuff%2C+Norbert%3BYang%2C+Yihong&rft.aulast=Geng&rft.aufirst=Xiujuan&rft.date=2011-03-01&rft.volume=30&rft.issue=3&rft.spage=747&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Medical+Imaging&rft.issn=02780062&rft_id=info:doi/10.1109%2FTMI.2010.2095027 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Transformation; Fibers; Anisotropy; Depth perception; Standard deviation; Atlases; Magnetic resonance imaging; Substantia alba; Diffusion; Mapping DO - http://dx.doi.org/10.1109/TMI.2010.2095027 ER - TY - JOUR T1 - Effects of neuroinflammation on the regenerative capacity of brain stem cells AN - 860393615; 14399982 AB - In the adult brain, neurogenesis under physiological conditions occurs in the subventricular zone and in the dentate gyrus. Although the exact molecular mechanisms that regulate neural stem cell proliferation and differentiation are largely unknown, several factors have been shown to affect neurogenesis. Decreased neurogenesis in the hippocampus has been recognized as one of the mechanisms of age-related brain dysfunction. Furthermore, in pathological conditions of the central nervous system associated with neuroinflammation, inflammatory mediators such as cytokines and chemokines can affect the capacity of brain stem cells and alter neurogenesis. In this review, we summarize the state of the art on the effects of neuroinflammation on adult neurogenesis and discuss the use of the lipopolysaccharide-model to study the effects of inflammation and reactive-microglia on brain stem cells and neurogenesis. Furthermore, we discuss the possible causes underlying reduced neurogenesis with normal aging and potential anti-inflammatory, pro-neurogenic interventions aimed at improving memory deficits in normal and pathological aging and in neurodegenerative diseases.Original Abstract: J. Neurochem. (2011) 116, 947-956. JF - Journal of Neurochemistry AU - Russo, Isabella AU - Barlati, Sergio AU - Bosetti, Francesca AD - Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, NIH, Bethesda, MD, USA Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 947 EP - 956 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 116 IS - 6 SN - 0022-3042, 0022-3042 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Age KW - Aging KW - Brain stem KW - Central nervous system KW - Chemokines KW - Cytokines KW - Dentate gyrus KW - Differentiation KW - Hippocampus KW - Inflammation KW - Memory KW - Molecular modelling KW - Neural stem cells KW - Neurodegenerative diseases KW - Neurogenesis KW - Reviews KW - subventricular zone KW - N3 11007:Neurobiology KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860393615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=Effects+of+neuroinflammation+on+the+regenerative+capacity+of+brain+stem+cells&rft.au=Russo%2C+Isabella%3BBarlati%2C+Sergio%3BBosetti%2C+Francesca&rft.aulast=Russo&rft.aufirst=Isabella&rft.date=2011-03-01&rft.volume=116&rft.issue=6&rft.spage=947&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/10.1111%2Fj.1471-4159.2010.07168.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Document feature - figure 1 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Central nervous system; Molecular modelling; Age; Chemokines; Hippocampus; subventricular zone; Brain stem; Aging; Dentate gyrus; Inflammation; Neurodegenerative diseases; Differentiation; Memory; Neurogenesis; Reviews; Cytokines; Neural stem cells DO - http://dx.doi.org/10.1111/j.1471-4159.2010.07168.x ER - TY - JOUR T1 - Early chemotherapy intensification with BEACOPP in advanced-stage Hodgkin lymphoma patients with a interim-PET positive after two ABVD courses. AN - 857481123; 21166786 AB - Interim 2-[18F]Fluoro-2-deoxy-D-glucose Positron Emission Tomography performed after two chemotherapy cycles (PET-2) is the most reliable predictor of treatment outcome in ABVD-treated Hodgkin Lymphoma (HL) patients. We retrospectively analysed the treatment outcome of a therapeutic strategy based on PET-2 results: positive patients switched to BEACOPP, while negative patients continued with ABVD. Between January 2006 and December 2007, 219 newly diagnosed HL patients admitted to nine centres were enrolled; 54 patients, unfit to receive this treatment were excluded from the analysis. PET-2 scans were reviewed by a central panel of nuclear medicine experts, according to the Deauville score (Meignan, 2009). After a median follow up of 34 months (12-52) the 2-year failure free survival (FFS) and overall survival for the entire cohort of 165 patients were 88% and 98%; the FFS was 65% for PET-2 positive and 92% for PET-2 negative patients. For 154 patients in which treatment was correctly given according to PET-2 review, the 2-year FFS was 91%: 62% for PET-2 positive and 95% for PET-2 negative patients. this strategy, with BEACOPP intensification only in PET-2 positive patients, showed better results than ABVD-treated historic controls, sparing BEACOPP toxicity to the majority of patients. © 2011 Blackwell Publishing Ltd. JF - British journal of haematology AU - Gallamini, Andrea AU - Patti, Caterina AU - Viviani, Simonetta AU - Rossi, Andrea AU - Fiore, Francesca AU - Di Raimondo, Francesco AU - Cantonetti, Maria AU - Stelitano, Caterina AU - Feldman, Tatyana AU - Gavarotti, Paolo AU - Sorasio, Roberto AU - Mulè, Antonino AU - Leone, Monica AU - Rambaldi, Alessandro AU - Biggi, Alberto AU - Barrington, Sally AU - Fallanca, Federico AU - Ficola, Umberto AU - Chauvie, Stéphane AU - Gianni, Alessandro Massimo AU - Gruppo Italiano Terapie Innovative nei Linfomi (GITIL) AD - Hematology Department and BMT Unit, Azienda Ospedaliera S. Croce e Carle, Via M. Coppino 26, Cuneo, Italy. gallamini.a@ospedale.cuneo.it ; Gruppo Italiano Terapie Innovative nei Linfomi (GITIL) Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 551 EP - 560 VL - 152 IS - 5 KW - Bleomycin KW - 11056-06-7 KW - Procarbazine KW - 35S93Y190K KW - Vincristine KW - 5J49Q6B70F KW - Vinblastine KW - 5V9KLZ54CY KW - Etoposide KW - 6PLQ3CP4P3 KW - Dacarbazine KW - 7GR28W0FJI KW - Doxorubicin KW - 80168379AG KW - Cyclophosphamide KW - 8N3DW7272P KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Positron-Emission Tomography KW - Epidemiologic Methods KW - Prednisone -- therapeutic use KW - Humans KW - Etoposide -- therapeutic use KW - Prognosis KW - Vinblastine -- therapeutic use KW - Procarbazine -- therapeutic use KW - Dacarbazine -- therapeutic use KW - Drug Substitution KW - Cyclophosphamide -- therapeutic use KW - Vincristine -- therapeutic use KW - Adult KW - Treatment Outcome KW - Doxorubicin -- therapeutic use KW - Middle Aged KW - Bleomycin -- therapeutic use KW - Female KW - Male KW - Hodgkin Disease -- drug therapy KW - Hodgkin Disease -- diagnostic imaging KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/857481123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+haematology&rft.atitle=Early+chemotherapy+intensification+with+BEACOPP+in+advanced-stage+Hodgkin+lymphoma+patients+with+a+interim-PET+positive+after+two+ABVD+courses.&rft.au=Gallamini%2C+Andrea%3BPatti%2C+Caterina%3BViviani%2C+Simonetta%3BRossi%2C+Andrea%3BFiore%2C+Francesca%3BDi+Raimondo%2C+Francesco%3BCantonetti%2C+Maria%3BStelitano%2C+Caterina%3BFeldman%2C+Tatyana%3BGavarotti%2C+Paolo%3BSorasio%2C+Roberto%3BMul%C3%A8%2C+Antonino%3BLeone%2C+Monica%3BRambaldi%2C+Alessandro%3BBiggi%2C+Alberto%3BBarrington%2C+Sally%3BFallanca%2C+Federico%3BFicola%2C+Umberto%3BChauvie%2C+St%C3%A9phane%3BGianni%2C+Alessandro+Massimo%3BGruppo+Italiano+Terapie+Innovative+nei+Linfomi+%28GITIL%29&rft.aulast=Gallamini&rft.aufirst=Andrea&rft.date=2011-03-01&rft.volume=152&rft.issue=5&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=British+journal+of+haematology&rft.issn=1365-2141&rft_id=info:doi/10.1111%2Fj.1365-2141.2010.08485.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-12 N1 - Date created - 2011-02-14 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00877747; ClinicalTrials.gov N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2141.2010.08485.x ER - TY - JOUR T1 - Effect of PCR extension temperature on high-throughput sequencing AN - 856790407; 14351682 AB - The DNA amplification process can be a source of bias and artifacts, especially when amplifying genomic areas with extreme AT or GC content. The human malaria parasite Plasmodium falciparum has an AT-rich genome, and some of its highly AT-rich regions have been shown to be refractory to polymerase chain reaction (PCR) amplification. Biased amplification may lead to erroneous conclusions for studies investigating genome-wide gene expression, nucleosome position, and copy number variation. Here we compare genome-wide nucleosome coverage in libraries amplified at three different extension temperatures and show that reduction in PCR extension temperature from 70 degree C to 60 degree C can greatly increase the fraction of coverage at AT-rich regions of the P. falciparum genome. Our method will improve the efficiency and coverage in sequencing an AT-rich genome. JF - Molecular and Biochemical Parasitology AU - Lopez-Barragan, Maria Jose AU - Quinones, Mariam AU - Cui, Kairong AU - Lemieux, Jacob AU - Zhao, Keji AU - Su, Xin-Zhuan AD - Laboratory of Malaria and Vector Research, National Institutes of Health, Bethesda, MD, USA, xsu@niaid.nih.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 64 EP - 67 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 176 IS - 1 SN - 0166-6851, 0166-6851 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - New generation sequencing KW - Malaria KW - Genome KW - Amplification bias KW - Nucleosome KW - Genomes KW - Temperature effects KW - Parasites KW - Human diseases KW - Nucleotide sequence KW - DNA KW - Polymerase chain reaction KW - Plasmodium falciparum KW - Public health KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856790407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Biochemical+Parasitology&rft.atitle=Effect+of+PCR+extension+temperature+on+high-throughput+sequencing&rft.au=Lopez-Barragan%2C+Maria+Jose%3BQuinones%2C+Mariam%3BCui%2C+Kairong%3BLemieux%2C+Jacob%3BZhao%2C+Keji%3BSu%2C+Xin-Zhuan&rft.aulast=Lopez-Barragan&rft.aufirst=Maria&rft.date=2011-03-01&rft.volume=176&rft.issue=1&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Biochemical+Parasitology&rft.issn=01666851&rft_id=info:doi/10.1016%2Fj.molbiopara.2010.11.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Temperature effects; Genomes; Parasites; Human diseases; Nucleotide sequence; DNA; Polymerase chain reaction; Malaria; Public health; Plasmodium falciparum DO - http://dx.doi.org/10.1016/j.molbiopara.2010.11.013 ER - TY - JOUR T1 - Differentiating new cannabis use from residual urinary cannabinoid excretion in chronic, daily cannabis users. AN - 856402864; 21134021 AB - To develop and validate empirically a mathematical model for identifying new cannabis use in chronic, daily cannabis smokers. Models were based on urinary creatinine-normalized (CN) cannabinoid excretion in chronic cannabis smokers. For model development, participants resided on a secure research unit for 30 days. For model validation, participants were abstinent with daily observed urine specimens for 28 days. A total of 48 (model development) and 67 (model validation) daily cannabis smokers were recruited. All voided urine was collected and analyzed for 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCCOOH) by gas chromatography-mass spectrometry (GCMS; limit of quantification 2.5 ng/ml) and creatinine (mg/ml). Urine THCCOOH was normalized to creatinine, yielding ng/mg CN-THCCOOH concentrations. Urine concentration ratios were determined from 123,513 specimen pairs collected 2-30 days apart. A mono-exponential model (with two parameters, initial urine specimen CN-THCCOOH concentration and time between specimens), based on the Marquardt-Levenberg algorithm, provided a reasonable data fit. Prediction intervals with varying probability levels (80, 90, 95, 99%) provide upper ratio limits for each urine specimen pair. Ratios above these limits suggest cannabis re-use. Disproportionate numbers of ratios were higher than expected for some participants, prompting development of two additional rules that avoid misidentification of re-use in participants with unusual CN-THCCOOH excretion patterns. For the first time, a validated model is available to aid in the differentiation of new cannabis use from residual creatinine-normalized 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (CN-THCCOOH) excretion in chronic, daily cannabis users. These models are valuable for clinicians, toxicologists and drug treatment staff and work-place, military and criminal justice drug-testing programs. © 2010 Society for the Study of Addiction. No claim to original US government works. JF - Addiction (Abingdon, England) AU - Schwilke, Eugene W AU - Gullberg, Rod G AU - Darwin, William D AU - Chiang, C Nora AU - Cadet, Jean Lud AU - Gorelick, David A AU - Pope, Harrison G AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, Baltimore, MD 21146, USA. Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 499 EP - 506 VL - 106 IS - 3 KW - Psychotropic Drugs KW - 0 KW - 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid KW - 4TPC9E4A32 KW - Dronabinol KW - 7J8897W37S KW - Creatinine KW - AYI8EX34EU KW - Index Medicus KW - Young Adult KW - Creatinine -- urine KW - Diagnosis, Differential KW - Humans KW - Algorithms KW - Predictive Value of Tests KW - Models, Biological KW - Recurrence KW - Drug Residues -- analysis KW - Adult KW - Gas Chromatography-Mass Spectrometry KW - Nonlinear Dynamics KW - Chronic Disease KW - Time Factors KW - Female KW - Male KW - Marijuana Abuse -- urine KW - Dronabinol -- analogs & derivatives KW - Dronabinol -- pharmacokinetics KW - Psychotropic Drugs -- pharmacokinetics KW - Psychotropic Drugs -- urine KW - Substance Abuse Detection -- methods KW - Substance Abuse Detection -- statistics & numerical data KW - Dronabinol -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856402864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Differentiating+new+cannabis+use+from+residual+urinary+cannabinoid+excretion+in+chronic%2C+daily+cannabis+users.&rft.au=Schwilke%2C+Eugene+W%3BGullberg%2C+Rod+G%3BDarwin%2C+William+D%3BChiang%2C+C+Nora%3BCadet%2C+Jean+Lud%3BGorelick%2C+David+A%3BPope%2C+Harrison+G%3BHuestis%2C+Marilyn+A&rft.aulast=Schwilke&rft.aufirst=Eugene&rft.date=2011-03-01&rft.volume=106&rft.issue=3&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=1360-0443&rft_id=info:doi/10.1111%2Fj.1360-0443.2010.03228.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-25 N1 - Date created - 2011-02-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Gen Psychiatry. 2001 Oct;58(10):909-15 [11576028] Ther Drug Monit. 2002 Dec;24(6):746-50 [12451292] Forensic Sci Int. 2003 Apr 23;133(1-2):26-31 [12742686] Forensic Sci Int. 2003 Nov 26;137(2-3):196-202 [14609657] J Pharmacol Exp Ther. 1980 Oct;215(1):35-44 [6256518] Clin Pharmacol Ther. 1985 Nov;38(5):572-8 [3902318] Drug Alcohol Depend. 2009 Nov 1;105(1-2):24-32 [19631478] J Anal Toxicol. 1996 Oct;20(6):441-52 [8889681] Ther Drug Monit. 1998 Oct;20(5):570-6 [9780137] J Anal Toxicol. 1998 Oct;22(6):445-54 [9788519] J Anal Toxicol. 1999 Sep;23(5):323-32 [10488918] J Anal Toxicol. 2008 Oct;32(8):562-9 [19007504] J Anal Toxicol. 2009 May;33(4):185-9 [19470219] Clin Chem. 1991 Nov;37(11):1927-31 [1934467] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1360-0443.2010.03228.x ER - TY - JOUR T1 - POST-TRIAL ACCESS TO ANTIRETROVIRALS: WHO OWES WHAT TO WHOM? AN - 855899658; 201107833 AB - Many recent articles argue that participants who seroconvert during HIV prevention trials deserve treatment when they develop AIDS, and there is a general consensus that the participants in HIV/AIDS treatment trials should have continuing post-trial access. As a result, the primary concern of many ethicists and activists has shifted from justifying an obligation to treat trial participants, to working out mechanisms through which treatment could be provided. In this paper I argue that this shift frequently conceals an important assumption: that if there is an obligation to supply treatment, then any party who could provide it may be prevailed upon to discharge the obligation. This assumption is false. The reasons why trial participants should get ART affect who has the duty to provide it. We should not burden governments with the obligations of sponsors, nor researchers with the obligations of the international community. And we should not deprive a group of treatment because their need is less salient than that of research participants. Insisting otherwise may lead to people being wrongfully deprived of access to antiretrovirals. Adapted from the source document. JF - Bioethics AU - Millum, Joseph Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 145 EP - 154 PB - Blackwell, Oxford UK VL - 25 IS - 3 SN - 0269-9702, 0269-9702 KW - HIV/AIDS antiretrovirals ART post-trial access KW - Activists KW - International community KW - Antiretroviral therapy KW - HIV KW - Preventive programmes KW - Treatment needs KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855899658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioethics&rft.atitle=POST-TRIAL+ACCESS+TO+ANTIRETROVIRALS%3A+WHO+OWES+WHAT+TO+WHOM%3F&rft.au=Millum%2C+Joseph&rft.aulast=Millum&rft.aufirst=Joseph&rft.date=2011-03-01&rft.volume=25&rft.issue=3&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Bioethics&rft.issn=02699702&rft_id=info:doi/10.1111%2Fj.1467-8519.2009.01736.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-03-07 N1 - Last updated - 2016-09-27 N1 - CODEN - BIETEE N1 - SubjectsTermNotLitGenreText - HIV; Antiretroviral therapy; Treatment needs; Preventive programmes; International community; Activists DO - http://dx.doi.org/10.1111/j.1467-8519.2009.01736.x ER - TY - JOUR T1 - Blood lead levels, ALAD gene polymorphisms, and mortality. AN - 855197810; 21293208 AB - Previous analyses from the National Health and Nutrition Examination Survey (NHANES III) have found that elevated blood lead levels may be associated with cardiovascular mortality, cancer mortality, and all-cause mortality. The 5-aminolevulinic acid dehydratase (ALAD) G177C genetic polymorphism (rs 1800435) affects lead toxicokinetics and may alter the adverse effects of lead exposure. We examined whether the ALAD G177C single nucleotide polymorphism (SNP) affects the relationship between lead and mortality. We analyzed a subset of 3349 genotyped NHANES III participants at least 40 years of age. Using Cox proportional hazards regression, we estimated the relative risk of all-cause, cardiovascular disease, and cancer mortality by ALAD genotype, and by blood lead levels (<5 μg/dL vs. ≥5 μg/dL). We also tested whether the ALAD genotype modified the relationship between blood lead level and mortality. The adjusted overall relative risk for participants with the variant ALAD genotype was decreased for all-cause mortality (hazards ratio = 0.68; [95% confidence interval = 0.50-0.93]) compared with persons having the common GG genotype. There was some suggestion that higher lead levels were associated with cancer mortality (1.48 [0.92-2.38]). We observed no convincing interaction effect between ALAD genotype and blood lead level on mortality risk. The ALAD genotype may be associated with decreased mortality from all causes and from cancer. This association does not seem to be affected by lead exposure. JF - Epidemiology (Cambridge, Mass.) AU - van Bemmel, Dana M AU - Li, Yan AU - McLean, Jody AU - Chang, Man-Huei AU - Dowling, Nicole F AU - Graubard, Barry AU - Rajaraman, Preetha AD - Cancer Prevention Fellowship Program, National Cancer Institute, Rockville, MD 20852, USA. vanbemmeld@mail.nih.gov Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 273 EP - 278 VL - 22 IS - 2 KW - Lead KW - 2P299V784P KW - 5-Aminolevulinate Synthetase KW - EC 2.3.1.37 KW - Index Medicus KW - Causality KW - Humans KW - Nutrition Surveys KW - Mortality -- trends KW - Middle Aged KW - Male KW - Female KW - Proportional Hazards Models KW - Lead -- adverse effects KW - Cardiovascular Diseases -- mortality KW - Neoplasms -- mortality KW - 5-Aminolevulinate Synthetase -- genetics KW - Polymorphism, Single Nucleotide -- genetics KW - Lead -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855197810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Blood+lead+levels%2C+ALAD+gene+polymorphisms%2C+and+mortality.&rft.au=van+Bemmel%2C+Dana+M%3BLi%2C+Yan%3BMcLean%2C+Jody%3BChang%2C+Man-Huei%3BDowling%2C+Nicole+F%3BGraubard%2C+Barry%3BRajaraman%2C+Preetha&rft.aulast=van+Bemmel&rft.aufirst=Dana&rft.date=2011-03-01&rft.volume=22&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=1531-5487&rft_id=info:doi/10.1097%2FEDE.0b013e3182093f75 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-13 N1 - Date created - 2011-02-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Gastroenterology. 2009 Feb;136(2):477-85.e11 [19100265] Am J Epidemiol. 2009 Jan 1;169(1):54-66 [18936436] Arch Intern Med. 2009 Mar 23;169(6):588-94 [19307522] Biometrics. 2009 Dec;65(4):1096-104 [19432778] Environ Health Perspect. 2000 Mar;108 Suppl 1:23-8 [10698721] Biol Chem. 2001 Jun;382(6):913-8 [11501755] Environ Health Perspect. 2002 Apr;110(4):325-9 [11940448] Environ Mol Mutagen. 2002;40(1):63-70 [12211078] Arch Intern Med. 2002 Nov 25;162(21):2443-9 [12437403] J Clin Invest. 1976 Aug;58(2):260-70 [783195] Ann Hum Genet. 1981 Jul;45(Pt 3):223-9 [7305279] Hum Genet. 1982;60(3):289-90 [7106762] Am J Epidemiol. 1985 Feb;121(2):246-58 [4014119] Int Arch Occup Environ Health. 1986;58(3):245-7 [3770964] Ann N Y Acad Sci. 1987;514:235-47 [3442387] Stat Med. 1989 May;8(5):551-61 [2657958] Pediatr Ann. 1990 Mar;19(3):208-14 [2181392] Environ Health Perspect. 1990 Jun;86:177-81 [2205487] Environ Health Perspect. 1991 Feb;91:33-7 [2040248] Am J Hum Genet. 1991 Oct;49(4):757-63 [1716854] Environ Res. 1991 Dec;56(2):109-19 [1769358] Arch Environ Health. 1994 Mar-Apr;49(2):98-105 [8161248] J Biol Chem. 1994 Apr 29;269(17):12399-402 [8175643] JAMA. 1994 Jul 27;272(4):284-91 [8028141] Vital Health Stat 1. 1994 Jul;(32):1-407 [7975354] Am J Epidemiol. 1995 Oct 1;142(7):738-45 [7572945] Environ Health Perspect. 1996 Jan;104(1):60-6 [8834863] Am J Epidemiol. 1997 Jan 1;145(1):72-80 [8982025] Fundam Appl Toxicol. 1997 Jan;35(1):84-90 [9024676] Pharmacol Toxicol. 1997 Oct;81(4):153-8 [9353844] Environ Res. 1998 Apr;77(1):49-61 [9593628] Trends Biochem Sci. 1998 Jun;23(6):217-21 [9644976] Environ Health Perspect. 2005 Sep;113(9):1209-11 [16140629] Biochim Biophys Acta. 2006 Sep;1762(9):819-27 [16935474] Environ Health Perspect. 2006 Oct;114(10):1538-41 [17035139] Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2514-20 [17164378] Environ Health Perspect. 2007 Jan;115(1):35-41 [17366816] J Toxicol Environ Health A. 2007 Dec;70(23):1986-94 [17966070] MMWR Recomm Rep. 2007 Nov 2;56(RR-8):1-16 [17975528] Cell Mol Biol (Noisy-le-grand). 2009;55(1):72-83 [19268005] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/EDE.0b013e3182093f75 ER - TY - JOUR T1 - Curcumin prevents DNA damage and enhances the repair potential in a chronically arsenic-exposed human population in West Bengal, India. AN - 852911808; 21332098 AB - Induction of oxidative stress and inhibition of DNA repair are possible modes of arsenic-induced carcinogenesis. In West Bengal, India, several districts contain high levels of arsenic, which are far above the WHO-recommended standard. Prevention of arsenic-induced oxidative stress and induction of repair enzymes by curcumin, an active ingredient of turmeric, may be an effective strategy to combat the adverse effects of arsenic. This study aimed at observing the role of curcumin in reducing 8-hydroxy-20-deoxyguanosine formation and enhancing DNA repair capacity in the arsenic-exposed population of West Bengal. Chronically arsenic-exposed volunteers (n= 66), who were asymptomatic, were selected for this study. Our results indicated that curcumin suppressed the 8-hydroxy-20-deoxyguanosine level and OGG1 expression, which were increased by arsenic. Curcumin also induced DNA repair enzymes involved in both base excision repair and nonhomologous end-joining pathways. In this study, both the protein expression and genetic profile were observed for poly-ADP-ribose polymerase 1, DNA b polymerase, X ray repair cross complement 1, DNA ligase III, DNA protein kinase catalytic sub-unit, X ray repair cross-complement 4, DNA ligase IV, and topoisomerase II b. The results indicated that arsenic-inhibited DNA repair was induced by curcumin, both at protein and genetic levels. Thus, curcumin intervention may be a useful modality for the prevention of arsenic-induced carcinogenesis. JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) AU - Roy, Madhumita AU - Sinha, Dona AU - Mukherjee, Sutapa AU - Biswas, Jaydip AD - Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, 37 S.P. Mukherjee Road, Kolkata, West Bengal, India. mitacnci@yahoo.co.in Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 123 EP - 131 VL - 20 IS - 2 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - DNA ligase III alpha protein, Xenopus KW - DNA-Binding Proteins KW - RNA, Messenger KW - XRCC4 protein, human KW - 8-oxo-7-hydrodeoxyguanosine KW - 88847-89-6 KW - Poly(ADP-ribose) Polymerases KW - EC 2.4.2.30 KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - DNA Topoisomerases, Type II KW - EC 5.99.1.3 KW - DNA topoisomerase II beta KW - DNA Ligases KW - EC 6.5.1.- KW - Deoxyguanosine KW - G9481N71RO KW - Curcumin KW - IT942ZTH98 KW - Index Medicus KW - Comet Assay KW - Humans KW - DNA Topoisomerases, Type II -- metabolism KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Poly(ADP-ribose) Polymerases -- metabolism KW - Blotting, Western KW - Deoxyguanosine -- metabolism KW - Adult KW - Middle Aged KW - DNA Ligases -- metabolism KW - Female KW - Male KW - DNA-Binding Proteins -- metabolism KW - DNA-Directed DNA Polymerase -- metabolism KW - Deoxyguanosine -- analogs & derivatives KW - Curcumin -- therapeutic use KW - Arsenic Poisoning -- blood KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Arsenic Poisoning -- drug therapy KW - DNA Repair -- drug effects KW - DNA Damage -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/852911808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+prevention+%3A+the+official+journal+of+the+European+Cancer+Prevention+Organisation+%28ECP%29&rft.atitle=Curcumin+prevents+DNA+damage+and+enhances+the+repair+potential+in+a+chronically+arsenic-exposed+human+population+in+West+Bengal%2C+India.&rft.au=Roy%2C+Madhumita%3BSinha%2C+Dona%3BMukherjee%2C+Sutapa%3BBiswas%2C+Jaydip&rft.aulast=Roy&rft.aufirst=Madhumita&rft.date=2011-03-01&rft.volume=20&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+prevention+%3A+the+official+journal+of+the+European+Cancer+Prevention+Organisation+%28ECP%29&rft.issn=1473-5709&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-03 N1 - Date created - 2011-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cancer and neurologic degeneration in xeroderma pigmentosum: long term follow-up characterises the role of DNA repair. AN - 852905987; 21097776 AB - The frequency of cancer, neurologic degeneration and mortality in xeroderma pigmentosum (XP) patients with defective DNA repair was determined in a four decade natural history study. All 106 XP patients admitted to the National Institutes of Health from 1971 to 2009 were evaluated from clinical records and follow-up. In the 65 per cent (n=69) of patients with skin cancer, non-melanoma skin cancer (NMSC) was increased 10,000-fold and melanoma was increased 2000-fold in patients under age 20. The 9 year median age at diagnosis of first non-melanoma skin cancer (NMSC) (n=64) was significantly younger than the 22 year median age at diagnosis of first melanoma (n=38)-a relative age reversal from the general population suggesting different mechanisms of carcinogenesis between NMSC and melanoma. XP patients with pronounced burning on minimal sun exposure (n=65) were less likely to develop skin cancer than those who did not. This may be related to the extreme sun protection they receive from an earlier age, decreasing their total ultraviolet exposure. Progressive neurologic degeneration was present in 24% (n=25) with 16/25 in complementation group XP-D. The most common causes of death were skin cancer (34%, n=10), neurologic degeneration (31%, n=9), and internal cancer (17%, n=5). The median age at death (29 years) in XP patients with neurodegeneration was significantly younger than those XP patients without neurodegeneration (37 years) (p=0.02). This 39 year follow-up study of XP patients indicates a major role of DNA repair genes in the aetiology of skin cancer and neurologic degeneration. JF - Journal of medical genetics AU - Bradford, Porcia T AU - Goldstein, Alisa M AU - Tamura, Deborah AU - Khan, Sikandar G AU - Ueda, Takahiro AU - Boyle, Jennifer AU - Oh, Kyu-Seon AU - Imoto, Kyoko AU - Inui, Hiroki AU - Moriwaki, Shin-Ichi AU - Emmert, Steffen AU - Pike, Kristen M AU - Raziuddin, Arati AU - Plona, Teri M AU - DiGiovanna, John J AU - Tucker, Margaret A AU - Kraemer, Kenneth H AD - Genetic Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, Maryland 20892-4258, USA. Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 168 EP - 176 VL - 48 IS - 3 KW - Receptor, Melanocortin, Type 1 KW - 0 KW - Index Medicus KW - Infant KW - Young Adult KW - Humans KW - Adult KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Child KW - Receptor, Melanocortin, Type 1 -- genetics KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Skin Neoplasms -- genetics KW - Neurodegenerative Diseases -- genetics KW - DNA Repair KW - Melanoma -- genetics KW - Xeroderma Pigmentosum -- genetics KW - Melanoma -- complications KW - Skin Neoplasms -- complications KW - Neurodegenerative Diseases -- mortality KW - Neurodegenerative Diseases -- complications KW - Xeroderma Pigmentosum -- complications KW - Skin Neoplasms -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/852905987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medical+genetics&rft.atitle=Cancer+and+neurologic+degeneration+in+xeroderma+pigmentosum%3A+long+term+follow-up+characterises+the+role+of+DNA+repair.&rft.au=Bradford%2C+Porcia+T%3BGoldstein%2C+Alisa+M%3BTamura%2C+Deborah%3BKhan%2C+Sikandar+G%3BUeda%2C+Takahiro%3BBoyle%2C+Jennifer%3BOh%2C+Kyu-Seon%3BImoto%2C+Kyoko%3BInui%2C+Hiroki%3BMoriwaki%2C+Shin-Ichi%3BEmmert%2C+Steffen%3BPike%2C+Kristen+M%3BRaziuddin%2C+Arati%3BPlona%2C+Teri+M%3BDiGiovanna%2C+John+J%3BTucker%2C+Margaret+A%3BKraemer%2C+Kenneth+H&rft.aulast=Bradford&rft.aufirst=Porcia&rft.date=2011-03-01&rft.volume=48&rft.issue=3&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Journal+of+medical+genetics&rft.issn=1468-6244&rft_id=info:doi/10.1136%2Fjmg.2010.083022 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-26 N1 - Date created - 2011-02-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Genet. 1980 Jan;17(1):39-45 [7389185] Ann Neurol. 1983 Jun;13(6):682-4 [6881931] Carcinogenesis. 1984 Apr;5(4):511-4 [6705149] Arch Dermatol. 1987 Feb;123(2):241-50 [3545087] N Engl J Med. 1988 Jun 23;318(25):1633-7 [3287161] JAMA. 1988 Jul 15;260(3):384-8 [3379749] Arch Dermatol. 1989 Feb;125(2):263-8 [2913963] JAMA. 1989 Oct 20;262(15):2097-100 [2795783] Brain. 1991 Jun;114 ( Pt 3):1335-61 [2065254] Eur Neurol. 1993;33(3):188-90 [8467834] J Clin Invest. 1993 Sep;92(3):1135-42 [7690772] J Am Acad Dermatol. 1994 May;30(5 Pt 1):774-8 [8176018] Arch Dermatol. 1994 Aug;130(8):1018-21 [8053698] J Invest Dermatol. 1996 Oct;107(4):647-53 [8823375] Arch Dermatol. 1997 Jun;133(6):735-40 [9197827] Mutat Res. 1997 Nov;385(2):107-14 [9447232] J Cutan Med Surg. 1998 Jan;2(3):153-8 [9479081] J Invest Dermatol. 1998 Apr;110(4):405-9 [9540983] Cancer Res. 1998 Oct 1;58(19):4402-9 [9766670] J Invest Dermatol. 1998 Nov;111(5):791-6 [9804340] Int J Cancer. 1999 May 5;81(3):345-50 [10209947] Int J Dermatol. 1999 Jul;38(7):511-4 [10440279] Int J Dermatol. 1999 Jul;38(7):520-4 [10440281] Cancer. 1962 Nov-Dec;15:1085-99 [13959369] Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2208-12 [16172233] Carcinogenesis. 2006 Jan;27(1):84-94 [16081512] Int J Cancer. 2006 Oct 15;119(8):1976-84 [16721784] Hum Mutat. 2006 Nov;27(11):1092-103 [16947863] Dermatol Surg. 2006 Dec;32(12):1473-9 [17199655] Hum Mutat. 2007 May;28(5):495-505 [17279550] Neuroscience. 2007 Apr 14;145(4):1388-96 [17276014] J Inherit Metab Dis. 1999 Dec;22(8):915-24 [10604143] Percept Mot Skills. 2000 Oct;91(2):447-50 [11065303] Neurology. 2000 Nov 28;55(10):1442-9 [11185579] J Invest Dermatol. 2001 Feb;116(2):224-9 [11179997] Am J Hum Genet. 2001 Apr;68(4):884-94 [11254446] Mutat Res. 2001 Feb 25;485(1):3-13 [11341989] J Invest Dermatol. 2001 Aug;117(2):294-300 [11511307] Hum Mol Genet. 2001 Oct 15;10(22):2539-47 [11709541] J Invest Dermatol. 2001 Nov;117(5):1151-5 [11710926] Eur J Paediatr Neurol. 2001;5(6):225-42 [11764181] Clin Neuropathol. 2002 Jan-Feb;21(1):18-23 [11846040] J Invest Dermatol. 2002 Jun;118(6):972-82 [12060391] Melanoma Res. 2002 Oct;12(5):405-16 [12394181] J Invest Dermatol. 2003 Jun;120(6):1087-93 [12787139] Hum Mol Genet. 2004 Feb 1;13(3):343-52 [14662655] Cancer Epidemiol Biomarkers Prev. 2004 May;13(5):808-19 [15159314] Nature. 1968 May 18;218(5142):652-6 [5655953] Ann Intern Med. 1974 Feb;80(2):221-48 [4811796] Comput Biomed Res. 1974 Aug;7(4):325-32 [4850570] Proc Natl Acad Sci U S A. 1975 Jan;72(1):59-63 [164028] Proc Natl Acad Sci U S A. 1978 Apr;75(4):1984-8 [273925] Trends Cell Biol. 2008 Jan;18(1):4-8 [18083030] Carcinogenesis. 2008 Mar;29(3):455-65 [18174245] BMC Genet. 2008;9:31 [18402696] J Invest Dermatol. 2008 Aug;128(8):2055-68 [18368133] Hum Mutat. 2008 Oct;29(10):1194-208 [18470933] DNA Repair (Amst). 2009 Jan 1;8(1):114-25 [18955168] J Oral Maxillofac Surg. 2009 Jan;67(1):22-31 [19070744] J Am Acad Dermatol. 2008 Nov;59(5):881-6 [19119101] Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6279-84 [19329485] FASEB J. 2009 Nov;23(11):3947-56 [19584301] Arch Dermatol. 2009 Nov;145(11):1285-91 [19917958] J Exp Med. 2009 Dec 21;206(13):3031-46 [19934020] Hum Mutat. 2010 Feb;31(2):167-75 [19953607] Arch Dermatol. 2010 Mar;146(3):283-7 [20231499] J Invest Dermatol. 2010 Apr;130(4):1188-91 [19956187] Arch Dermatol. 1980 May;116(5):541-2 [7377784] J Invest Dermatol. 1979 Jul;73(1):102-7 [448168] Cutis. 1980 Mar;25(3):311-3 [7357893] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/jmg.2010.083022 ER - TY - JOUR T1 - Interpreting borderline BeLPT results. AN - 850559108; 20957676 AB - The beryllium lymphocyte proliferation test (BeLPT) identifies persons sensitized to beryllium (BeS) and thus at risk for chronic beryllium disease (CBD). BeLPT test results are abnormal (AB), borderline (BL), or normal (NL). This manuscript addresses the predictive value and interpretation of BL BeLPT results. The various three-result combinations that meet or exceed a nominal referral criteria of 1 AB + 1 BL are assessed with probability modeling and compared. At 2% prevalence, the three-result combinations that meet or exceed this referral criteria and associated probabilities of BeS are: (a) 1 AB + 1 BL + 1 NL (72%); (b) 3 BL (91%); (c) 2 AB + 1 NL (95%); (d) 1 AB + 2 BL (99%); (e) 2 AB + 1 BL (100%); and (f) 3 AB (100%). These results suggest that BL results are meaningful and that three BL results predict BeS across a broad range of population prevalences. An analysis of longitudinal BeLPT results and clinical findings from an actual surveillance program is warranted to confirm the model's predictions. Copyright © 2010 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Middleton, D C AU - Mayer, A S AU - Lewin, M D AU - Mroz, M M AU - Maier, L A AD - Agency for Toxic Substances and Disease Registry, Division of Health Studies, National Institutes of Health, Atlanta, GA 30341, USA. dmiddleton@cdc.gov Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 205 EP - 209 VL - 54 IS - 3 KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - Sensitivity and Specificity KW - Risk Factors KW - Humans KW - Algorithms KW - Predictive Value of Tests KW - Longitudinal Studies KW - Decision Making KW - United States -- epidemiology KW - Time Factors KW - Prevalence KW - Berylliosis -- etiology KW - Lymphocytes -- radiation effects KW - Berylliosis -- epidemiology KW - Occupational Exposure -- adverse effects KW - Berylliosis -- diagnosis KW - Beryllium -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/850559108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Interpreting+borderline+BeLPT+results.&rft.au=Middleton%2C+D+C%3BMayer%2C+A+S%3BLewin%2C+M+D%3BMroz%2C+M+M%3BMaier%2C+L+A&rft.aulast=Middleton&rft.aufirst=D&rft.date=2011-03-01&rft.volume=54&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=1097-0274&rft_id=info:doi/10.1002%2Fajim.20909 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-25 N1 - Date created - 2011-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ajim.20909 ER - TY - JOUR T1 - Oxaliplatin plus dual inhibition of thymidilate synthase during preoperative pelvic radiotherapy for locally advanced rectal carcinoma: long-term outcome. AN - 848820695; 20472346 AB - To assess the safety and efficacy of oxaliplatin (OXA) plus dual inhibition of thymidilate synthase during preoperative pelvic radiotherapy (RT) in patients with poor prognosis for rectal carcinoma. Sixty-three patients with the following characteristics, a clinical (c) stage T4, cN1-2, or cT3N0 of ≤5 cm from the anal verge and/or with a circumferential resection margin (CRM) of ≤5 mm (by magnetic resonance imaging), received three biweekly courses of chemotherapy with OXA, 100 mg/m2; raltitrexed (RTX), 2.5 mg/m2 on day 1, and 5-fluorouracil (5-FU), 900 mg/m2 (31 patients) or 800 mg/m2 (32 patients); levo-folinic acid (LFA), 250 mg/m2 on day 2, during pelvic RT (45 Gy). Pathologic response was defined as complete pathological response (ypCR), major (tumor regression grade(TRG) 2 to 3, with ypCRM-ve and ypN-ve) or minor or no response (TRG4 to -5, or ypCRM+ve, or ypN+ve). Adjuvant 5-FU/LFA regimen was given in cases of cT4, ypN+ve, or ypCRM+ve. Overall, neutropenia (40%) and diarrhea (13%) were the most common grade≥3 toxicities, and tolerability was better with a 5-FU dose reduction. No significant difference in pathologic response was seen according 5-FU dosage: overall, a ypCR was obtained in 24 (39%) patients, and a major response in 20 (32%) patients. The 5-year probability of freedom from recurrence was 80% (95% confidence interval, 68%-92%); it was 56% for the minor/no response group, while it was around 90% for both the ypCR and the major response group. OXA, RTX, and 5-FU/LFA administered during pelvic RT produced promising early and long-term results in rectal carcinoma patients with poor prognosis. The postoperative treatment strategy applied in our study supports the risk-adapted approach in postoperative management. Copyright © 2011 Elsevier Inc. All rights reserved. JF - International journal of radiation oncology, biology, physics AU - Avallone, Antonio AU - Delrio, Paolo AU - Pecori, Biagio AU - Tatangelo, Fabiana AU - Petrillo, Antonella AU - Scott, Nigel AU - Marone, Pietro AU - Aloi, Luigi AU - Sandomenico, Claudia AU - Lastoria, Secondo AU - Iaffaioli, Vincenzo Rosario AU - Scala, Dario AU - Iodice, Giovanni AU - Budillon, Alfredo AU - Comella, Pasquale AD - Department of Gastrointestinal Medical Oncology, National Cancer Institute, Naples, Italy. avalloneantonio@libero.it Y1 - 2011/03/01/ PY - 2011 DA - 2011 Mar 01 SP - 670 EP - 676 VL - 79 IS - 3 KW - Neoplasm Proteins KW - 0 KW - Organoplatinum Compounds KW - Quinazolines KW - Thiophenes KW - oxaliplatin KW - 04ZR38536J KW - Vitamin B Complex KW - 12001-76-2 KW - Thymidylate Synthase KW - EC 2.1.1.45 KW - raltitrexed KW - FCB9EGG971 KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Combined Modality Therapy -- methods KW - Neoplasm Staging KW - Neutropenia -- etiology KW - Humans KW - Leucovorin -- administration & dosage KW - Prognosis KW - Aged KW - Combined Modality Therapy -- adverse effects KW - Quinazolines -- administration & dosage KW - Fluorouracil -- administration & dosage KW - Vitamin B Complex -- administration & dosage KW - Fluorouracil -- adverse effects KW - Preoperative Care -- methods KW - Radiotherapy Dosage KW - Adult KW - Treatment Outcome KW - Remission Induction -- methods KW - Middle Aged KW - Postoperative Complications -- pathology KW - Diarrhea -- etiology KW - Thiophenes -- administration & dosage KW - Female KW - Male KW - Rectal Neoplasms -- drug therapy KW - Neoplasm Proteins -- antagonists & inhibitors KW - Rectal Neoplasms -- enzymology KW - Rectal Neoplasms -- pathology KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Adenocarcinoma -- radiotherapy KW - Adenocarcinoma -- pathology KW - Adenocarcinoma -- enzymology KW - Thymidylate Synthase -- antagonists & inhibitors KW - Organoplatinum Compounds -- adverse effects KW - Rectal Neoplasms -- surgery KW - Rectal Neoplasms -- radiotherapy KW - Organoplatinum Compounds -- therapeutic use KW - Adenocarcinoma -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Adenocarcinoma -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/848820695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Oxaliplatin+plus+dual+inhibition+of+thymidilate+synthase+during+preoperative+pelvic+radiotherapy+for+locally+advanced+rectal+carcinoma%3A+long-term+outcome.&rft.au=Avallone%2C+Antonio%3BDelrio%2C+Paolo%3BPecori%2C+Biagio%3BTatangelo%2C+Fabiana%3BPetrillo%2C+Antonella%3BScott%2C+Nigel%3BMarone%2C+Pietro%3BAloi%2C+Luigi%3BSandomenico%2C+Claudia%3BLastoria%2C+Secondo%3BIaffaioli%2C+Vincenzo+Rosario%3BScala%2C+Dario%3BIodice%2C+Giovanni%3BBudillon%2C+Alfredo%3BComella%2C+Pasquale&rft.aulast=Avallone&rft.aufirst=Antonio&rft.date=2011-03-01&rft.volume=79&rft.issue=3&rft.spage=670&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=1879-355X&rft_id=info:doi/10.1016%2Fj.ijrobp.2009.12.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-11 N1 - Date created - 2011-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ijrobp.2009.12.007 ER - TY - JOUR T1 - Do interleukin polymorphisms play a role in the prevention of colorectal adenoma recurrence by dietary flavonols? AN - 847598532; 21160427 AB - Chemopreventive dietary compounds, such as flavonols, may inhibit colorectal carcinogenesis partly by altering cytokine expression and attenuating inflammation. Single nucleotide polymorphisms (SNPs) in the promoter regions of genes encoding cytokines may influence flavonol-induced changes in cytokine expression and consequently cancer risk. Using logistic regression, we estimated odds ratios (OR) and 95% confidence intervals (CI) for the association between SNPs of interleukin (IL)-1β, 6, 8, and 10 alone or combined with flavonol intake or serum IL concentration changes, and adenoma recurrence in 808 participants from the intervention arm of the Polyp Prevention Trial, a 4-year intervention study evaluating the effectiveness of a low-fat, high-fiber, high-fruit and vegetable diet on adenoma recurrence. Overall, SNPs in genes encoding IL-1β, 6, 8, and 10 were not associated with their corresponding serum concentrations or adenoma recurrence. However, individuals homozygous for IL-10 -592 C (OR=2.23, 95% CI: 1.07-4.66, P(interaction)=0.03) orIL-10 -819 C (OR=2.18, 95% CI: 1.05-4.51, P(interaction)=0.05) had an elevated risk of high-risk adenoma recurrence when their serum IL-10 concentrations increased during the trial. In addition, IL-6 -174 GG in combination with above median flavonol intake (OR=0.14, 95% CI: 0.03-0.66) or with decreased IL-6 concentrations (OR=0.14, 95% CI: 0.03-0.65) reduced the risk of advanced adenoma recurrence, although the interaction term was not statistically significant. In conclusion, our results suggest that IL SNPs, in combination with a flavonol-rich diet or decreased serum IL, may lower the risk of adenoma recurrence. JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) AU - Bobe, Gerd AU - Murphy, Gwen AU - Albert, Paul S AU - Sansbury, Leah B AU - Young, Matthew R AU - Lanza, Elaine AU - Schatzkin, Arthur AU - Colburn, Nancy H AU - Cross, Amanda J AD - Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. gerd.bobe@oregonstate.edu Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 86 EP - 95 VL - 20 IS - 2 KW - Flavonols KW - 0 KW - Interleukin-6 KW - Interleukins KW - Interleukin-10 KW - 130068-27-8 KW - Index Medicus KW - Humans KW - Interleukin-6 -- genetics KW - Prognosis KW - Aged KW - Middle Aged KW - Interleukin-10 -- genetics KW - Male KW - Female KW - Colorectal Neoplasms -- genetics KW - Polymorphism, Single Nucleotide -- physiology KW - Interleukins -- genetics KW - Neoplasm Recurrence, Local -- prevention & control KW - Flavonols -- therapeutic use KW - Colorectal Neoplasms -- pathology KW - Adenoma -- prevention & control KW - Diet KW - Adenoma -- genetics KW - Adenoma -- pathology KW - Colorectal Neoplasms -- prevention & control KW - Neoplasm Recurrence, Local -- genetics KW - Neoplasm Recurrence, Local -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/847598532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+prevention+%3A+the+official+journal+of+the+European+Cancer+Prevention+Organisation+%28ECP%29&rft.atitle=Do+interleukin+polymorphisms+play+a+role+in+the+prevention+of+colorectal+adenoma+recurrence+by+dietary+flavonols%3F&rft.au=Bobe%2C+Gerd%3BMurphy%2C+Gwen%3BAlbert%2C+Paul+S%3BSansbury%2C+Leah+B%3BYoung%2C+Matthew+R%3BLanza%2C+Elaine%3BSchatzkin%2C+Arthur%3BColburn%2C+Nancy+H%3BCross%2C+Amanda+J&rft.aulast=Bobe&rft.aufirst=Gerd&rft.date=2011-03-01&rft.volume=20&rft.issue=2&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+prevention+%3A+the+official+journal+of+the+European+Cancer+Prevention+Organisation+%28ECP%29&rft.issn=1473-5709&rft_id=info:doi/10.1097%2FCEJ.0b013e3283429e45 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-03 N1 - Date created - 2011-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 1998 Oct 1;102(7):1369-76 [9769329] Cancer Epidemiol Biomarkers Prev. 1996 May;5(5):385-92 [9162305] J Nutr Biochem. 2005 Mar;16(3):155-62 [15741050] Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2359-65 [16214917] Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):494-501 [16537707] Eur J Cancer Prev. 2006 Jun;15(3):249-53 [16679868] Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1126-31 [16775170] Biochem Pharmacol. 2006 Oct 16;72(8):1010-21 [16934226] J Agric Food Chem. 2006 Dec 27;54(26):9798-804 [17177504] Cancer Res. 2007 Feb 1;67(3):1062-71 [17283139] J Nutr. 2007 May;137(5):1244-52 [17449588] J Clin Invest. 2007 May;117(5):1175-83 [17476347] Eur J Cancer. 2007 May;43(8):1283-9 [17446060] Oncol Rep. 2007 Aug;18(2):473-81 [17611673] Mol Cancer Ther. 2007 Sep;6(9):2544-53 [17876051] Int J Cancer. 2007 Nov 1;121(9):2001-4 [17640058] Cancer Causes Control. 2007 Dec;18(10):1095-105 [17694420] Anticancer Res. 2007 Sep-Oct;27(5B):3577-87 [17972520] Cancer Res. 2008 Feb 1;68(3):946-55 [18245498] J Nutr. 2008 Apr;138(4):753-60 [18356331] Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1344-53 [18559549] Carcinogenesis. 2008 Aug;29(8):1572-80 [18628251] Clin Cancer Res. 2008 Nov 1;14(21):6735-41 [18980965] J Cell Biochem. 2009 Jan 1;106(1):73-82 [19009557] Cancer Lett. 2009 Mar 8;275(1):17-26 [18995957] Cancer Cell. 2009 Feb 3;15(2):103-13 [19185845] Int J Colorectal Dis. 2009 Mar;24(3):289-94 [18704460] Respir Med. 2009 Mar;103(3):364-72 [19010653] Food Chem Toxicol. 2009 Apr;47(4):809-12 [19271315] Eur J Gynaecol Oncol. 2009;30(1):60-4 [19317259] Clin Cancer Res. 2009 Sep 15;15(18):5878-87 [19737943] Nutr Cancer. 2009;61(4):554-63 [19838928] Cancer Causes Control. 2009 Nov;20(9):1739-51 [19760027] Phytother Res. 2010 Jan;24(1):119-28 [19504466] Carcinogenesis. 2010 Jan;31(1):37-49 [19955394] J Nutr. 2010 Feb;140(2):278-84 [20032478] Cancer Prev Res (Phila). 2010 Jun;3(6):764-75 [20484173] J Biol Chem. 1999 Nov 5;274(45):32091-8 [10542243] Public Health Nutr. 1999 Dec;2(4):565-9 [10656476] N Engl J Med. 2000 Apr 20;342(16):1149-55 [10770979] J Biol Chem. 2000 Jun 16;275(24):18138-44 [10747905] Mol Diagn. 2000 Dec;5(4):329-40 [11172497] Carcinogenesis. 2001 Apr;22(4):665-71 [11285204] Am J Clin Nutr. 2001 Sep;74(3):387-401 [11522565] Biochem Biophys Res Commun. 2002 Jan 11;290(1):469-74 [11779194] Cell Mol Life Sci. 2002 Mar;59(3):560-9 [11964134] Genes Immun. 2002 Nov;3(7):407-13 [12424622] Gastroenterology. 2002 Dec;123(6):1793-803 [12454835] Immunogenetics. 2003 Dec;55(9):629-32 [14605776] Genes Immun. 2004 Jun;5(4):274-82 [15085176] Gut. 2004 Aug;53(8):1082-9 [15247172] Epidemiology. 1990 Jan;1(1):58-64 [2081241] Arthritis Rheum. 1999 Jun;42(6):1101-8 [10366102] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/CEJ.0b013e3283429e45 ER - TY - JOUR T1 - Blood-derived human osteoclast resorption activity is impaired by Hyaluronan-CD44 engagement via a p38-dependent mechanism. AN - 821973424; 20799279 AB - The control of bone resorption is crucial in osteolytic diseases. Once attached to bone, osteoclasts (OCs) initiate the resorption process through the activation of a complex cascade of morphological and biochemical changes. Hyaluronan (HA), an extracellular glycosaminoglycan long non-branching polysaccharide, is expressed in bone matrices. Here we demonstrate that HA counter-balances the erosion activity of human mature OCs by significantly reducing their degradative potential. HA treatment of fully differentiated OCs derived from human peripheral blood monocytes inhibited migration on collagen as well as bone resorption. HA-mediated effects were primarily due to TRAcP, MMP-9, and cathepsin K down-regulation and to the increased levels of TIMP-1, a natural MMP-9 inhibitor. Binding of HA to mature OCs was entirely mediated by CD44: function-blocking anti-CD44 antibodies fully abrogated HA effects, and the engagement of HA receptor caused a rapid de-phosphorylation of Ser325 in the CD44 cytoplasmic tail. The inhibitory action by HA was associated with a transient up-phosphorylation of Pyk2, a novel persistent phosphorylation of p38 and the down-regulation of NFATc1 transcription factor. Our results provide a direct evidence for the involvement of CD44 in the HA-dependent regulation of OC activity and suggest a signaling pathway that could be unique in OC function inhibition. Copyright © 2010 Wiley-Liss, Inc. JF - Journal of cellular physiology AU - Pivetta, Eliana AU - Scapolan, Martina AU - Wassermann, Bruna AU - Steffan, Agostino AU - Colombatti, Alfonso AU - Spessotto, Paola AD - Experimental Oncology 2, CRO, IRCCS, National Cancer Institute, Aviano, PN, Italy. Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 769 EP - 779 VL - 226 IS - 3 KW - Antigens, CD44 KW - 0 KW - Isoenzymes KW - NFATC Transcription Factors KW - Hyaluronic Acid KW - 9004-61-9 KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Acid Phosphatase KW - EC 3.1.3.2 KW - Tartrate-Resistant Acid Phosphatase KW - Index Medicus KW - Acid Phosphatase -- metabolism KW - Cell Survival -- drug effects KW - Protein Binding -- drug effects KW - Humans KW - Cell Shape -- drug effects KW - Cell Movement -- drug effects KW - NFATC Transcription Factors -- metabolism KW - Down-Regulation -- drug effects KW - Cell Differentiation -- drug effects KW - Models, Biological KW - Isoenzymes -- metabolism KW - Osteoclasts -- enzymology KW - Bone Resorption -- enzymology KW - Osteoclasts -- pathology KW - Osteoclasts -- drug effects KW - Bone Resorption -- blood KW - Hyaluronic Acid -- pharmacology KW - Antigens, CD44 -- metabolism KW - p38 Mitogen-Activated Protein Kinases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821973424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+physiology&rft.atitle=Blood-derived+human+osteoclast+resorption+activity+is+impaired+by+Hyaluronan-CD44+engagement+via+a+p38-dependent+mechanism.&rft.au=Pivetta%2C+Eliana%3BScapolan%2C+Martina%3BWassermann%2C+Bruna%3BSteffan%2C+Agostino%3BColombatti%2C+Alfonso%3BSpessotto%2C+Paola&rft.aulast=Pivetta&rft.aufirst=Eliana&rft.date=2011-03-01&rft.volume=226&rft.issue=3&rft.spage=769&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+physiology&rft.issn=1097-4652&rft_id=info:doi/10.1002%2Fjcp.22398 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-27 N1 - Date created - 2010-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jcp.22398 ER - TY - JOUR T1 - T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis AN - 1668268061; PQ0001269967 AB - Autologous T lymphocytes genetically engineered to express a murine T cell receptor (TCR) against human carcinoembryonic antigen (CEA) were administered to three patients with metastatic colorectal cancer refractory to standard treatments. All patients experienced profound decreases in serum CEA levels (74-99%), and one patient had an objective regression of cancer metastatic to the lung and liver. However, a severe transient inflammatory colitis that represented a dose limiting toxicity was induced in all three patients. This report represents the first example of objective regression of metastatic colorectal cancer mediated by adoptive T cell transfer and illustrates the successful use of a TCR, raised in human leukocyte antigen (HLA) transgenic mice, against a human tumor associated antigen. It also emphasizes the destructive power of small numbers of highly avid T cells and the limitations of using CEA as a target for cancer immunotherapy. JF - Molecular Therapy AU - Parkhurst, Maria R AU - Yang, James C AU - Langan, Russell C AU - Dudley, Mark E AU - Nathan, Debbie-Ann N AU - Feldman, Steven A AU - Davis, Jeremy L AU - Morgan, Richard A AU - Merino, Maria J AU - Sherry, Richard M AD - National Institutes of Health, National Cancer Institute, Surgery Branch, Bldg. CRC Rm. 4-5744, 9000 Rockville Pike, Bethesda, MD 20892, USA, Maria_Parkhurst@nih.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 620 EP - 626 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 19 IS - 3 SN - 1525-0016, 1525-0016 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Histocompatibility antigen HLA KW - T-cell receptor KW - Immunotherapy KW - Carcinoembryonic antigen KW - Colorectal cancer KW - Toxicity KW - Tumors KW - Transgenic mice KW - Inflammation KW - Metastases KW - Genetic engineering KW - Antigen (tumor-associated) KW - Liver KW - Lymphocytes T KW - Colitis KW - W 30925:Genetic Engineering KW - F 06960:Molecular Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668268061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=T+Cells+Targeting+Carcinoembryonic+Antigen+Can+Mediate+Regression+of+Metastatic+Colorectal+Cancer+but+Induce+Severe+Transient+Colitis&rft.au=Parkhurst%2C+Maria+R%3BYang%2C+James+C%3BLangan%2C+Russell+C%3BDudley%2C+Mark+E%3BNathan%2C+Debbie-Ann+N%3BFeldman%2C+Steven+A%3BDavis%2C+Jeremy+L%3BMorgan%2C+Richard+A%3BMerino%2C+Maria+J%3BSherry%2C+Richard+M&rft.aulast=Parkhurst&rft.aufirst=Maria&rft.date=2011-03-01&rft.volume=19&rft.issue=3&rft.spage=620&rft.isbn=&rft.btitle=&rft.title=Molecular+Therapy&rft.issn=15250016&rft_id=info:doi/10.1038%2Fmt.2010.272 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; T-cell receptor; Immunotherapy; Carcinoembryonic antigen; Colorectal cancer; Tumors; Toxicity; Transgenic mice; Inflammation; Metastases; Genetic engineering; Antigen (tumor-associated); Lymphocytes T; Liver; Colitis DO - http://dx.doi.org/10.1038/mt.2010.272 ER - TY - JOUR T1 - Protein domain assignment from the recurrence of locally similar structures AN - 1529943872; 19893441 AB - Domains are basic units of protein structure and essential for exploring protein fold space and structure evolution. With the structural genomics initiative, the number of protein structures in the Protein Databank (PDB) is increasing dramatically and domain assignments need to be done automatically. Most existing structural domain assignment programs define domains using the compactness of the domains and/or the number and strength of intra-domain versus inter-domain contacts. Here we present a different approach based on the recurrence of locally similar structural pieces (LSSPs) found by one-against-all structure comparisons with a dataset of 6373 protein chains from the PDB. Residues of the query protein are clustered using LSSPs via three different procedures to define domains. This approach gives results that are comparable to several existing programs that use geometrical and other structural information explicitly. Remarkably, most of the proteins that contribute the LSSPs defining a domain do not themselves contain the domain of interest. This study shows that domains can be defined by a collection of relatively small locally similar structural pieces containing, on average, four secondary structure elements. In addition, it indicates that domains are indeed made of recurrent small structural pieces that are used to build protein structures of many different folds as suggested by recent studies. Proteins 2011. Published 2010 Wiley-Liss, Inc. JF - Proteins: Structure, Function and Bioinformatics AU - Tai, Chin-Hsien AU - Sam, Vichetra AU - Gibrat, Jean-Francois AU - Garnier, Jean AU - Munson, Peter J AU - Lee, Byungkook AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892. Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 853 EP - 866 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030 United States VL - 79 IS - 3 SN - 0887-3585, 0887-3585 KW - Biotechnology and Bioengineering Abstracts KW - Protein structure KW - Protein folding KW - Secondary structure KW - genomics KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1529943872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteins%3A+Structure%2C+Function+and+Bioinformatics&rft.atitle=Protein+domain+assignment+from+the+recurrence+of+locally+similar+structures&rft.au=Tai%2C+Chin-Hsien%3BSam%2C+Vichetra%3BGibrat%2C+Jean-Francois%3BGarnier%2C+Jean%3BMunson%2C+Peter+J%3BLee%2C+Byungkook&rft.aulast=Tai&rft.aufirst=Chin-Hsien&rft.date=2011-03-01&rft.volume=79&rft.issue=3&rft.spage=853&rft.isbn=&rft.btitle=&rft.title=Proteins%3A+Structure%2C+Function+and+Bioinformatics&rft.issn=08873585&rft_id=info:doi/10.1002%2Fprot.22923 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-05-01 N1 - Last updated - 2014-06-12 N1 - SubjectsTermNotLitGenreText - Protein structure; Protein folding; Secondary structure; Bioinformatics; genomics DO - http://dx.doi.org/10.1002/prot.22923 ER - TY - JOUR T1 - A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets AN - 1399905924; 16690126 AB - Genes that are highly overexpressed in tumor cells can be required for tumor cell survival and have the potential to be selective therapeutic targets. In an attempt to identify such targets, we combined a functional genomics and a systems biology approach to assess the consequences of RNAi-mediated silencing of overexpressed genes that were selected from 140 gene expression profiles from colorectal cancers (CRCs) and matched normal mucosa. In order to identify credible models for in-depth functional analysis, we first confirmed the overexpression of these genes in 25 different CRC cell lines. We then identified five candidate genes that profoundly reduced the viability of CRC cell lines when silenced with either siRNAs or short-hairpin RNAs (shRNAs), i.e., HMGA1, TACSTD2, RRM2, RPS2 and NOL5A. These genes were further studied by systematic analysis of comprehensive gene expression profiles generated following siRNA-mediated silencing. Exploration of these RNAi-specific gene expression signatures allowed the identification of the functional space in which the five genes operate and showed enrichment for cancer-specific signaling pathways, some known to be involved in CRC. By comparing the expression of the RNAi signature genes with their respective expression levels in an independent set of primary rectal carcinomas, we could recapitulate these defined RNAi signatures, therefore, establishing the biological relevance of our observations. This strategy identified the signaling pathways that are affected by the prominent oncogenes HMGA1 and TACSTD2, established a yet unknown link between RRM2 and PLK1 and identified RPS2 and NOL5A as promising potential therapeutic targets in CRC. JF - International Journal of Cancer AU - Grade, Marian AU - Hummon, Amanda B AU - Camps, Jordi AU - Emons, Georg AU - Spitzner, Melanie AU - Gaedcke, Jochen AU - Hoermann, Patrick AU - Ebner, Reinhard AU - Becker, Heinz AU - Difilippantonio, Michael J AU - Ghadimi, B Michael AU - Beissbarth, Tim AU - Caplen, Natasha J AU - Ried, Thomas AD - Department of General and Visceral Surgery, University Medicine Gottingen, Georg-August-University, Gottingen, Germany, riedt@mail.nih.gov Y1 - 2011/03/01/ PY - 2011 DA - 2011 Mar 01 SP - 1069 EP - 1079 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 128 IS - 5 SN - 1097-0215, 1097-0215 KW - Biotechnology and Bioengineering Abstracts KW - Cell survival KW - Rectum KW - Mucosa KW - Colorectal cancer KW - Tumor cells KW - Carcinoma KW - Gene expression KW - Oncogenes KW - siRNA KW - polo-like kinase 1 KW - RNA-mediated interference KW - genomics KW - Gene silencing KW - Signal transduction KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1399905924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=A+genomic+strategy+for+the+functional+validation+of+colorectal+cancer+genes+identifies+potential+therapeutic+targets&rft.au=Grade%2C+Marian%3BHummon%2C+Amanda+B%3BCamps%2C+Jordi%3BEmons%2C+Georg%3BSpitzner%2C+Melanie%3BGaedcke%2C+Jochen%3BHoermann%2C+Patrick%3BEbner%2C+Reinhard%3BBecker%2C+Heinz%3BDifilippantonio%2C+Michael+J%3BGhadimi%2C+B+Michael%3BBeissbarth%2C+Tim%3BCaplen%2C+Natasha+J%3BRied%2C+Thomas&rft.aulast=Grade&rft.aufirst=Marian&rft.date=2011-03-01&rft.volume=128&rft.issue=5&rft.spage=1069&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=10970215&rft_id=info:doi/10.1002%2Fijc.25453 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ijc.25453/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-07-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Cell survival; Rectum; Mucosa; Colorectal cancer; Tumor cells; Carcinoma; Gene expression; Oncogenes; siRNA; polo-like kinase 1; RNA-mediated interference; genomics; Signal transduction; Gene silencing DO - http://dx.doi.org/10.1002/ijc.25453 ER - TY - JOUR T1 - Nonparametric estimation for length-biased and right-censored data AN - 1171870266; 16123618 AB - This paper considers survival data arising from length-biased sampling, where the survival times are left truncated by uniformly distributed random truncation times. We propose a nonparametric estimator that incorporates the information about the length-biased sampling scheme. The new estimator retains the simplicity of the truncation product-limit estimator with a closed-form expression, and has a small efficiency loss compared with the nonparametric maximum likelihood estimator, which requires an iterative algorithm. Moreover, the asymptotic variance of the proposed estimator has a closed form, and a variance estimator is easily obtained by plug-in methods. Numerical simulation studies with practical sample sizes are conducted to compare the performance of the proposed method with its competitors. A data analysis of the Canadian Study of Health and Aging is conducted to illustrate the methods and theory. JF - Biometrika AU - Huang, Chiung-Yu AU - Qin, Jing AD - Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, U.S.A. Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 177 EP - 186 VL - 98 IS - 1 SN - 1464-3510, 1464-3510 KW - Biotechnology and Bioengineering Abstracts KW - Aging KW - Algorithms KW - Data processing KW - Mathematical models KW - Sampling KW - Survival KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1171870266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrika&rft.atitle=Nonparametric+estimation+for+length-biased+and+right-censored+data&rft.au=Huang%2C+Chiung-Yu%3BQin%2C+Jing&rft.aulast=Huang&rft.aufirst=Chiung-Yu&rft.date=2011-03-01&rft.volume=98&rft.issue=1&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Biometrika&rft.issn=14643510&rft_id=info:doi/10.1093%2Fbiomet%2Fasq069 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-11-01 N1 - Last updated - 2012-12-03 N1 - SubjectsTermNotLitGenreText - Mathematical models; Data processing; Aging; Algorithms; Survival; Sampling DO - http://dx.doi.org/10.1093/biomet/asq069 ER - TY - JOUR T1 - Alcohol Exposure and Mechanisms of Tissue Injury and Repair AN - 1125242872; 14397635 AB - Tissue injury owing to acute and chronic alcohol consumption has extensive medical consequences, with the level and duration of alcohol exposure affecting both the magnitude of injury and the time frame to recovery. While the understanding of many of the molecular processes disrupted by alcohol has advanced, mechanisms of alcohol-induced tissue injury remain a subject of intensive research. Alcohol has multiple targets, as it affects diverse cellular and molecular processes. Some mechanisms of tissue damage as a result of alcohol may be common to many tissue types, while others are likely to be tissue specific. Here, we present a discussion of the alcohol-induced molecular and cellular disruptions associated with injury or recovery from injury in bone, muscle, skin, and gastric mucosa. In every case, the goal of characterizing the sites of alcohol action is to devise potential measures for protection, prevention, or therapeutic intervention. JF - Alcoholism: Clinical and Experimental Research AU - Jung, MKatherine AU - Callaci, John J AU - Lauing, Kristen L AU - Otis, Jeffrey S AU - Radek, Katherine A AU - Jones, Michael K AU - Kovacs, Elizabeth J AD - From the Division of Metabolism and Health Effects (MKJ), National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland; Alcohol Research Program, Burn & Shock Trauma Institute, Department of Orthopaedic Surgery (JJC, KLL), Loyola University Stritch School of Medicine, Maywood, Illinois; Alcohol Research Program, Burn & Shock Trauma Institute, Department of Surgery (EJK), Loyola University Stritch School of Medicine, Maywood, Illinois; Division of Pulmonary, Allergy, and Critical Care Medicine (JSO), Emory University School of Medicine, Atlanta, Georgia; VA San Diego Healthcare System and Division of Dermatology, Department of Medicine (KAR), University of California, San Diego, California; and Research Healthcare Group, VA Long Beach Healthcare System, Long Beach, California and Department of Medicine (MKJ), University of California, Irvine, California. Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 392 EP - 399 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 35 IS - 3 SN - 0145-6008, 0145-6008 KW - Toxicology Abstracts KW - Indexing in process UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1125242872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%3A+Clinical+and+Experimental+Research&rft.atitle=Alcohol+Exposure+and+Mechanisms+of+Tissue+Injury+and+Repair&rft.au=Jung%2C+MKatherine%3BCallaci%2C+John+J%3BLauing%2C+Kristen+L%3BOtis%2C+Jeffrey+S%3BRadek%2C+Katherine+A%3BJones%2C+Michael+K%3BKovacs%2C+Elizabeth+J&rft.aulast=Jung&rft.aufirst=MKatherine&rft.date=2011-03-01&rft.volume=35&rft.issue=3&rft.spage=392&rft.isbn=&rft.btitle=&rft.title=Alcoholism%3A+Clinical+and+Experimental+Research&rft.issn=01456008&rft_id=info:doi/10.1111%2Fj.1530-0277.2010.01356.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Document feature - figure 3 N1 - Last updated - 2012-11-02 DO - http://dx.doi.org/10.1111/j.1530-0277.2010.01356.x ER - TY - JOUR T1 - Measuring the Impact of Research AN - 1038043607; 201208761 AB - The ability to monitor the growth and structure of scientific knowledge is now within information professionals grasp due primarily to the work of large-scale indexes like Thomson-Reuters' Web of Science, Elsevier's Scopus, and the National Library of Medicine's PubMed. The pools of research funding around the world have been shrinking. This has increased competition for scarce funds and put additional pressure on funding organizations to show the value of their research expenditures. Information professionals are ideal candidates to develop a set of services to help our organizations define and defend their value. It requires a clear understanding of the organization and its preferred measures of success, but this goal is achievable and provides immense value. Adapted from the source document. JF - Information Outlook AU - King, James AD - National Institutes of Health, Bethesda, MD Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 17 EP - 19 PB - Special Libraries Association, Alexandria VA VL - 15 IS - 2 SN - 1091-0808, 1091-0808 KW - Bibliometrics KW - Research centers KW - Role KW - Information professionals KW - article KW - 5.24: BIBLIOMETRICS, SCIENTOMETRICS, INFORMETRICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038043607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Information+Outlook&rft.atitle=Measuring+the+Impact+of+Research&rft.au=King%2C+James&rft.aulast=King&rft.aufirst=James&rft.date=2011-03-01&rft.volume=15&rft.issue=2&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Information+Outlook&rft.issn=10910808&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Information professionals; Bibliometrics; Research centers; Role ER - TY - JOUR T1 - ppGpp is the major source of growth rate control in E. coli AN - 1028076455; 14398906 AB - It is widely accepted that the DNA, RNA and protein content of Enterobacteriaceae is regulated as a function of exponential growth rates; macromolecular content increases with faster growth regardless of specific composition of the growth medium. This phenomenon, called growth rate control, primarily involves regulation of ribosomal RNA and ribosomal protein synthesis. However, it was uncertain whether the global regulator ppGpp is the major determinant for growth rate control. Therefore, here we re-evaluate the effect of ppGpp on macromolecular content for different balanced growth rates in defined media. We find that when ppGpp is absent, RNA/protein and RNA/DNA ratios are equivalent in fast and slow growing cells. Moreover, slow growing ppGpp-deficient cells with increased RNA content, display a normal ribosomal subunit composition although polysome content is reduced when compared with fast growing wild-type cells. From this we conclude that growth rate control does not occur in the absence of ppGpp. Also, artificial elevation of ppGpp or introduction of stringent RNA polymerase mutants in ppGpp-deficient cells restores this control. We believe these findings strongly argue in favour of ppGpp and against redundant regulation of growth rate control by other factors in Escherichia coli and other enteric bacteria. JF - Environmental Microbiology AU - Potrykus, Katarzyna AU - Murphy, Helen AU - Philippe, Nadege AU - Cashel, Michael AD - Laboratory of Molecular Genetics, Program in Genomics of Development, Eunice Kennedy Shriver NICHD, NIH, Bethesda, MD 20892-2785, USA. Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 563 EP - 575 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 13 IS - 3 SN - 1462-2912, 1462-2912 KW - Microbiology Abstracts B: Bacteriology KW - Growth rate KW - Polyribosomes KW - rRNA KW - Macromolecules KW - DNA-directed RNA polymerase KW - Ribosomal proteins KW - Escherichia coli KW - DNA KW - Ribosomal subunits KW - Enterobacteriaceae KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028076455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Microbiology&rft.atitle=ppGpp+is+the+major+source+of+growth+rate+control+in+E.+coli&rft.au=Potrykus%2C+Katarzyna%3BMurphy%2C+Helen%3BPhilippe%2C+Nadege%3BCashel%2C+Michael&rft.aulast=Potrykus&rft.aufirst=Katarzyna&rft.date=2011-03-01&rft.volume=13&rft.issue=3&rft.spage=563&rft.isbn=&rft.btitle=&rft.title=Environmental+Microbiology&rft.issn=14622912&rft_id=info:doi/10.1111%2Fj.1462-2920.2010.02357.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Document feature - figure 5 N1 - Last updated - 2013-07-26 N1 - SubjectsTermNotLitGenreText - Polyribosomes; Growth rate; rRNA; DNA-directed RNA polymerase; Macromolecules; Ribosomal proteins; DNA; Ribosomal subunits; Escherichia coli; Enterobacteriaceae DO - http://dx.doi.org/10.1111/j.1462-2920.2010.02357.x ER - TY - JOUR T1 - The double life of a bacterial lipoprotein AN - 1028074839; 14400602 AB - It has been known for many years that the small lipoprotein Lpp, which is the most abundant protein in E. coli, exists in two forms. The 'bound' form of the protein is tethered to the outer membrane (OM) by its N-terminal lipid moiety and covalently attached to the cell wall by its C-terminal lysine residue. The exact location of the 'free' form, however, has never been determined. In this issue of Molecular Microbiology, Cowles etal. demonstrate that the free form of Lpp is an integral OM protein whose C-terminus is exposed on the cell surface. The new study provides the first example of a lipoprotein that has a dual localization and adds to a growing body of evidence that lipoproteins can span the OM despite the lack of an obvious transmembrane segment. Furthermore, the new results raise intriguing questions about the assembly of both lipoproteins and other types of OM proteins. JF - Molecular Microbiology AU - Bernstein, Harris D AD - Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 1128 EP - 1131 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 79 IS - 5 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts B: Bacteriology KW - Cell surface KW - Lipids KW - Lipoproteins KW - Outer membranes KW - C-Terminus KW - Escherichia coli KW - Lysine KW - Cell walls KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028074839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=The+double+life+of+a+bacterial+lipoprotein&rft.au=Bernstein%2C+Harris+D&rft.aulast=Bernstein&rft.aufirst=Harris&rft.date=2011-03-01&rft.volume=79&rft.issue=5&rft.spage=1128&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2011.07538.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Document feature - figure 1 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Cell surface; Lipids; C-Terminus; Outer membranes; Lipoproteins; Lysine; Cell walls; Escherichia coli DO - http://dx.doi.org/10.1111/j.1365-2958.2011.07538.x ER - TY - JOUR T1 - Cumulative incidence of cancer among individuals with acquired immunodeficiency syndrome in the United States AN - 1017966721; 16688873 AB - BACKGROUND: The overall burden of cancer may increase as individuals with acquired immunodeficiency syndrome (AIDS) live longer because of highly active antiretroviral therapy (HAART), which has been widely available since 1996. METHODS: A population-based, record-linkage study identified cancers in 472,378 individuals with AIDS from 1980 to 2006. By using nonparametric competing-risk methods, the cumulative incidence of cancer was estimated across 3 calendar periods (AIDS onset in 1980-1989, 1990-1995, and 1996-2006). RESULTS: Measured at 5 years after AIDS onset, the cumulative incidence of AIDS-defining cancer (ADC) declined sharply across the 3 AIDS calendar periods (from 18% in 1980-1989, to 11% in 1990-1995, to 4.2% in 1996-2006 [ie, the HAART era]). The cumulative incidence of Kaposi sarcoma declined from 14.3% during 1980 to 1989, to 6.7% during 1990 to 1995, and to 1.8% during 1996 to 2006. The cumulative incidence of non-Hodgkin lymphoma (NHL) declined from 3.8% during 1990 through 1995 to 2.2% during 1996 through 2006; during the HAART era, NHL was the most common ADC (53%). The cumulative incidence of non-AIDS-defining cancer (NADC) increased from 1.1% to 1.5% with no change thereafter (1%; 1996-2006), in part because of declines in competing mortality. However, cumulative incidence increased steadily over time for specific NADCs (anal cancer, Hodgkin lymphoma, and liver cancer). The cumulative incidence of lung cancer increased from 0.14% during 1980 to 1989 to 0.32% during 1990 to 1995, and no change was observed thereafter. CONCLUSIONS: Dramatically declining cumulative incidence was noted in 2 major ADCs (Kaposi sarcoma and NHL), and increases were observed in some NADCs (specifically, cancers of the anus, liver, and lung and Hodgkin lymphoma). As HIV/AIDS is increasingly managed as a chronic disease, greater attention should be focused on cancer screening and prevention. Cancer 2011. Published 2010 by American Cancer Society. JF - Cancer AU - Simard, Edgar P AU - Pfeiffer, Ruth M AU - Engels, Eric A Y1 - 2011/03/01/ PY - 2011 DA - 2011 Mar 01 SP - 1089 EP - 1096 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 117 IS - 5 SN - 1097-0142, 1097-0142 KW - Immunology Abstracts; Risk Abstracts KW - Mortality KW - Acquired immune deficiency syndrome KW - Hodgkin's disease KW - Liver cancer KW - Immunodeficiency KW - Cancer KW - Anus KW - USA KW - Human immunodeficiency virus KW - highly active antiretroviral therapy KW - antiretroviral agents KW - Liver KW - prevention KW - Sarcoma KW - lymphoma KW - Lung cancer KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017966721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Cumulative+incidence+of+cancer+among+individuals+with+acquired+immunodeficiency+syndrome+in+the+United+States&rft.au=Simard%2C+Edgar+P%3BPfeiffer%2C+Ruth+M%3BEngels%2C+Eric+A&rft.aulast=Simard&rft.aufirst=Edgar&rft.date=2011-03-01&rft.volume=117&rft.issue=5&rft.spage=1089&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=10970142&rft_id=info:doi/10.1002%2Fcncr.25547 L2 - http://onlinelibrary.wiley.com/doi/10.1002/cncr.25547/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Anus; Mortality; Acquired immune deficiency syndrome; Hodgkin's disease; highly active antiretroviral therapy; Liver cancer; Sarcoma; Immunodeficiency; Lung cancer; Human immunodeficiency virus; antiretroviral agents; prevention; Liver; lymphoma; Cancer; USA DO - http://dx.doi.org/10.1002/cncr.25547 ER - TY - CPAPER T1 - Roles of Retinoic Acid in Immunity T2 - 2011 Keystone Symposia on Mucosal Biology: A Fine Balance between Tolerance and Immunity (X5) AN - 1313022204; 6065635 JF - 2011 Keystone Symposia on Mucosal Biology: A Fine Balance between Tolerance and Immunity (X5) AU - Belkaid, Yasmine Y1 - 2011/02/26/ PY - 2011 DA - 2011 Feb 26 KW - Retinoic acid KW - Immunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313022204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Mucosal+Biology%3A+A+Fine+Balance+between+Tolerance+and+Immunity+%28X5%29&rft.atitle=Roles+of+Retinoic+Acid+in+Immunity&rft.au=Belkaid%2C+Yasmine&rft.aulast=Belkaid&rft.aufirst=Yasmine&rft.date=2011-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Mucosal+Biology%3A+A+Fine+Balance+between+Tolerance+and+Immunity+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1100&CFID=357953&CFTOKEN=93291377 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Ocular Immune Privilege, T Regulatory Cells and Autoimmunity T2 - 2011 Keystone Symposia on Mucosal Biology: A Fine Balance between Tolerance and Immunity (X5) AN - 1313007121; 6065629 JF - 2011 Keystone Symposia on Mucosal Biology: A Fine Balance between Tolerance and Immunity (X5) AU - Caspi, Rachel Y1 - 2011/02/26/ PY - 2011 DA - 2011 Feb 26 KW - Lymphocytes T KW - Immunoregulation KW - Immune privilege KW - Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313007121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Mucosal+Biology%3A+A+Fine+Balance+between+Tolerance+and+Immunity+%28X5%29&rft.atitle=Ocular+Immune+Privilege%2C+T+Regulatory+Cells+and+Autoimmunity&rft.au=Caspi%2C+Rachel&rft.aulast=Caspi&rft.aufirst=Rachel&rft.date=2011-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Mucosal+Biology%3A+A+Fine+Balance+between+Tolerance+and+Immunity+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1100&CFID=357953&CFTOKEN=93291377 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - TLR Agonists and/or IL-15 Adjuvanted Mucosal SIV-Vaccine Prevented Gut CD4+ Memory T Cell Loss After SIVmac251-Challenge in Macaques T2 - 2011 Keystone Symposia on Mucosal Biology: A Fine Balance between Tolerance and Immunity (X5) AN - 1313006670; 6065617 JF - 2011 Keystone Symposia on Mucosal Biology: A Fine Balance between Tolerance and Immunity (X5) AU - Sui, Jun Y1 - 2011/02/26/ PY - 2011 DA - 2011 Feb 26 KW - Memory cells KW - Digestive tract KW - Lymphocytes T KW - Immunological memory KW - CD4 antigen KW - Interleukin 15 KW - Mucosa KW - Macaca UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313006670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Mucosal+Biology%3A+A+Fine+Balance+between+Tolerance+and+Immunity+%28X5%29&rft.atitle=TLR+Agonists+and%2For+IL-15+Adjuvanted+Mucosal+SIV-Vaccine+Prevented+Gut+CD4%2B+Memory+T+Cell+Loss+After+SIVmac251-Challenge+in+Macaques&rft.au=Sui%2C+Jun&rft.aulast=Sui&rft.aufirst=Jun&rft.date=2011-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Mucosal+Biology%3A+A+Fine+Balance+between+Tolerance+and+Immunity+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1100&CFID=357953&CFTOKEN=93291377 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Is the Direct Targeting of the Mucosa Necessary for an HIV Vaccine? T2 - 2011 Keystone Symposia on Mucosal Biology: A Fine Balance between Tolerance and Immunity (X5) AN - 1313006632; 6065616 JF - 2011 Keystone Symposia on Mucosal Biology: A Fine Balance between Tolerance and Immunity (X5) AU - Franchini, Genoveffa Y1 - 2011/02/26/ PY - 2011 DA - 2011 Feb 26 KW - Human immunodeficiency virus KW - vaccines KW - Vaccines KW - Mucosa KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313006632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Mucosal+Biology%3A+A+Fine+Balance+between+Tolerance+and+Immunity+%28X5%29&rft.atitle=Is+the+Direct+Targeting+of+the+Mucosa+Necessary+for+an+HIV+Vaccine%3F&rft.au=Franchini%2C+Genoveffa&rft.aulast=Franchini&rft.aufirst=Genoveffa&rft.date=2011-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Mucosal+Biology%3A+A+Fine+Balance+between+Tolerance+and+Immunity+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1100&CFID=357953&CFTOKEN=93291377 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - LPS Promotes IL-35-Dependent Suppression of Allergen-Induced Airway Disease T2 - 2011 Keystone Symposia on Mucosal Biology: A Fine Balance between Tolerance and Immunity (X5) AN - 1312992781; 6065605 JF - 2011 Keystone Symposia on Mucosal Biology: A Fine Balance between Tolerance and Immunity (X5) AU - Cook, Donald Y1 - 2011/02/26/ PY - 2011 DA - 2011 Feb 26 KW - Respiratory tract diseases KW - Lipopolysaccharides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312992781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Mucosal+Biology%3A+A+Fine+Balance+between+Tolerance+and+Immunity+%28X5%29&rft.atitle=LPS+Promotes+IL-35-Dependent+Suppression+of+Allergen-Induced+Airway+Disease&rft.au=Cook%2C+Donald&rft.aulast=Cook&rft.aufirst=Donald&rft.date=2011-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Mucosal+Biology%3A+A+Fine+Balance+between+Tolerance+and+Immunity+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1100&CFID=357953&CFTOKEN=93291377 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The IL-13 Decoy Receptor Tightly Controls Pathogenic Th17 and Th2 Responses in the Mucosa T2 - 2011 Keystone Symposia on Mucosal Biology: A Fine Balance between Tolerance and Immunity (X5) AN - 1312992698; 6065603 JF - 2011 Keystone Symposia on Mucosal Biology: A Fine Balance between Tolerance and Immunity (X5) AU - Wynn, Thomas Y1 - 2011/02/26/ PY - 2011 DA - 2011 Feb 26 KW - Lymphocytes T KW - Helper cells KW - Mucosa KW - Interleukin 13 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312992698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Mucosal+Biology%3A+A+Fine+Balance+between+Tolerance+and+Immunity+%28X5%29&rft.atitle=The+IL-13+Decoy+Receptor+Tightly+Controls+Pathogenic+Th17+and+Th2+Responses+in+the+Mucosa&rft.au=Wynn%2C+Thomas&rft.aulast=Wynn&rft.aufirst=Thomas&rft.date=2011-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Mucosal+Biology%3A+A+Fine+Balance+between+Tolerance+and+Immunity+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1100&CFID=357953&CFTOKEN=93291377 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Host Chemokines Bind to Staphylococcus aureus and Stimulate Protein A Release AN - 907158335; 14372440 AB - There are few examples of host signals that are beneficial to bacteria during infection. Here we found that 31 out of 42 host immunoregulatory chemokines were able to induce release of the virulence factor protein A (SPA) from a strain of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). Detailed study of chemokine CXCL9 revealed that SPA release occurred through a post-translational mechanism and was inversely proportional to bacterial density. CXCL9 bound specifically to the cell membrane of CA-MRSA, and the related SPA-releasing chemokine CXCL10 bound to both cell wall and cell membrane. Clinical samples from patients infected with S. aureus and samples from a mouse model of CA-MRSA skin abscess all contained extracellular SPA. Further, SPA-releasing chemokines were present in mouse skin lesions infected with CA-MRSA. Our data identify a potential new mode of immune evasion, in which the pathogen exploits a host defense factor to release a virulence factor; moreover, chemokine binding may serve a scavenging function in immune evasion by S. aureus. JF - Journal of Biological Chemistry AU - Yung, Sunny C AU - Parenti, David AU - Murphy, Philip M AD - From the Molecular Signaling Section, Laboratory of Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 and the Department of Medicine, George Washington University Medical Center, Washington, D Y1 - 2011/02/18/ PY - 2011 DA - 2011 Feb 18 SP - 5069 EP - 5077 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 286 IS - 7 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Immunoregulation KW - Chemokines KW - Data processing KW - virulence factors KW - protein A KW - Drug resistance KW - Animal models KW - Pathogens KW - Abscesses KW - Infection KW - CXCL10 protein KW - Cell membranes KW - Skin diseases KW - Post-translation KW - Staphylococcus aureus KW - Cell walls KW - J 02410:Animal Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907158335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Host+Chemokines+Bind+to+Staphylococcus+aureus+and+Stimulate+Protein+A+Release&rft.au=Yung%2C+Sunny+C%3BParenti%2C+David%3BMurphy%2C+Philip+M&rft.aulast=Yung&rft.aufirst=Sunny&rft.date=2011-02-18&rft.volume=286&rft.issue=7&rft.spage=5069&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Immunoregulation; Chemokines; Data processing; virulence factors; Drug resistance; protein A; Animal models; Pathogens; Infection; Abscesses; CXCL10 protein; Cell membranes; Post-translation; Skin diseases; Cell walls; Staphylococcus aureus ER - TY - JOUR T1 - Arachidonic acid stimulates formation of a novel complex containing nucleolin and RhoA. AN - 851935595; 21281639 AB - Arachidonic acid (AA) stimulates cell adhesion through a p38 mitogen activated protein kinase-mediated RhoA signaling pathway. Here we report that a proteomic screen following AA-treatment identified nucleolin, a multifunctional nucleolar protein, in a complex with the GTPase, RhoA, that also included the Rho kinase, ROCK. AA-stimulated cell adhesion was inhibited by expression of nucleolin-targeted shRNA and formation of the multiprotein complex was blocked by expression of dominant-negative RhoA. AA-treatment also induced ROCK-dependent serine phosphorylation of nucleolin and translocation of nucleolin from the nucleus to the cytoplasm, where it appeared to co-localize with RhoA. These data suggest the existence of a new signaling pathway through which the location and post-translational state of nucleolin are modulated. Copyright © 2011. Published by Elsevier B.V. JF - FEBS letters AU - Garcia, Melissa C AU - Williams, Jason AU - Johnson, Katina AU - Olden, Kenneth AU - Roberts, John D AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2011/02/18/ PY - 2011 DA - 2011 Feb 18 SP - 618 EP - 622 VL - 585 IS - 4 KW - Mutant Proteins KW - 0 KW - Phosphoproteins KW - Protein Kinase Inhibitors KW - RNA, Small Interfering KW - RNA-Binding Proteins KW - Recombinant Fusion Proteins KW - nucleolin KW - RHOA protein, human KW - 124671-05-2 KW - Arachidonic Acid KW - 27YG812J1I KW - Serine KW - 452VLY9402 KW - rho-Associated Kinases KW - EC 2.7.11.1 KW - rhoA GTP-Binding Protein KW - EC 3.6.5.2 KW - Index Medicus KW - Cell Nucleus -- metabolism KW - Gene Silencing KW - Humans KW - Mutant Proteins -- metabolism KW - Immunoprecipitation KW - RNA, Small Interfering -- genetics KW - RNA, Small Interfering -- metabolism KW - rho-Associated Kinases -- antagonists & inhibitors KW - Serine -- metabolism KW - Recombinant Fusion Proteins -- metabolism KW - Mutant Proteins -- genetics KW - Proteomics -- methods KW - rho-Associated Kinases -- metabolism KW - Phosphorylation KW - Cytoplasm -- metabolism KW - Amino Acid Substitution KW - Cell Line KW - Protein Transport KW - Cell Adhesion KW - rhoA GTP-Binding Protein -- metabolism KW - RNA-Binding Proteins -- antagonists & inhibitors KW - rhoA GTP-Binding Protein -- genetics KW - RNA-Binding Proteins -- metabolism KW - Phosphoproteins -- antagonists & inhibitors KW - Arachidonic Acid -- metabolism KW - Phosphoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/851935595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=Arachidonic+acid+stimulates+formation+of+a+novel+complex+containing+nucleolin+and+RhoA.&rft.au=Garcia%2C+Melissa+C%3BWilliams%2C+Jason%3BJohnson%2C+Katina%3BOlden%2C+Kenneth%3BRoberts%2C+John+D&rft.aulast=Garcia&rft.aufirst=Melissa&rft.date=2011-02-18&rft.volume=585&rft.issue=4&rft.spage=618&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=1873-3468&rft_id=info:doi/10.1016%2Fj.febslet.2011.01.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-04-01 N1 - Date created - 2011-02-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cytoskeleton (Hoboken). 2010 Sep;67(9):545-54 [20803696] Cancer Metastasis Rev. 2010 Mar;29(1):223-37 [20112053] J Biol Chem. 2000 Apr 14;275(15):11284-90 [10753939] Exp Cell Res. 2000 Dec 15;261(2):312-28 [11112338] Cancer Res. 2001 Mar 15;61(6):2445-52 [11289113] J Lipid Res. 2001 Oct;42(10):1521-42 [11590208] J Biol Chem. 2004 Jan 30;279(5):3300-7 [14607845] Cancer Res. 1996 May 1;56(9):2206-12 [8616873] FEBS Lett. 1997 Mar 10;404(2-3):118-24 [9119047] J Biol Chem. 1998 Nov 27;273(48):31718-25 [9822633] Crit Rev Biochem Mol Biol. 1998;33(6):407-36 [9918513] Bioessays. 2005 Jun;27(6):602-13 [15892119] Bull Cancer. 2005 Jul;92(7):697-707 [16123008] J Cell Physiol. 2006 Feb;206(2):545-55 [16245305] Biochem Biophys Res Commun. 2006 Sep 22;348(2):540-9 [16889753] Biochim Biophys Acta. 2006 Nov;1761(11):1335-43 [17052951] J Biol Chem. 2007 Oct 19;282(42):30763-75 [17702752] Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3357-61 [18292223] Exp Cell Res. 2008 Jul 1;314(11-12):2212-23 [18504038] J Biol Chem. 2009 Jul 31;284(31):20936-45 [19506078] J Biol Chem. 2009 Oct 9;284(41):28410-9 [19661056] Nat Rev Cancer. 2010 Jan;10(1):9-22 [20029421] FASEB J. 1999 Nov;13(14):1911-22 [10544174] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.febslet.2011.01.035 ER - TY - CPAPER T1 - Risk, Resilience, and Gene-Environment Interplay in Primates T2 - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AN - 1312989456; 6044937 JF - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AU - Suomi, Stephen Y1 - 2011/02/17/ PY - 2011 DA - 2011 Feb 17 KW - Primates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312989456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.atitle=Risk%2C+Resilience%2C+and+Gene-Environment+Interplay+in+Primates&rft.au=Suomi%2C+Stephen&rft.aulast=Suomi&rft.aufirst=Stephen&rft.date=2011-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://aaas.confex.com/aaas/2011/webprogram/start.html#srch=method|and|pge|1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Comparative Effectiveness in Traumatic Brain Injury: Problem Rich/Solution Poor? T2 - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AN - 1312975826; 6045023 JF - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AU - Koroshetz, Walter Y1 - 2011/02/17/ PY - 2011 DA - 2011 Feb 17 KW - Brain KW - Traumatic brain injury UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312975826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.atitle=Comparative+Effectiveness+in+Traumatic+Brain+Injury%3A+Problem+Rich%2FSolution+Poor%3F&rft.au=Koroshetz%2C+Walter&rft.aulast=Koroshetz&rft.aufirst=Walter&rft.date=2011-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://aaas.confex.com/aaas/2011/webprogram/start.html#srch=method|and|pge|1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Alzheimer's Disease Neuroimaging Initiative: Assessing Disease Progression T2 - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AN - 1312965604; 6045297 JF - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AU - Buckholtz, Neil Y1 - 2011/02/17/ PY - 2011 DA - 2011 Feb 17 KW - Alzheimer's disease KW - Neuroimaging KW - Neurodegenerative diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312965604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.atitle=Alzheimer%27s+Disease+Neuroimaging+Initiative%3A+Assessing+Disease+Progression&rft.au=Buckholtz%2C+Neil&rft.aulast=Buckholtz&rft.aufirst=Neil&rft.date=2011-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://aaas.confex.com/aaas/2011/webprogram/start.html#srch=method|and|pge|1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Environmental Health Perspectives: An Interdisciplinary Journal Reaches Out T2 - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AN - 1312959914; 6045014 JF - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AU - Sen, Banalata Y1 - 2011/02/17/ PY - 2011 DA - 2011 Feb 17 KW - Environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312959914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.atitle=Environmental+Health+Perspectives%3A+An+Interdisciplinary+Journal+Reaches+Out&rft.au=Sen%2C+Banalata&rft.aulast=Sen&rft.aufirst=Banalata&rft.date=2011-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://aaas.confex.com/aaas/2011/webprogram/start.html#srch=method|and|pge|1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Lessons Learned from Genetic and Epidemiologic Studies of Cancer T2 - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AN - 1312959419; 6044804 JF - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AU - Wacholder, Sholom Y1 - 2011/02/17/ PY - 2011 DA - 2011 Feb 17 KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312959419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.atitle=Lessons+Learned+from+Genetic+and+Epidemiologic+Studies+of+Cancer&rft.au=Wacholder%2C+Sholom&rft.aulast=Wacholder&rft.aufirst=Sholom&rft.date=2011-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://aaas.confex.com/aaas/2011/webprogram/start.html#srch=method|and|pge|1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - NIH Beyond Research: Strengthening Work Force and Institutions in Developing Countries T2 - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AN - 1312946043; 6044884 JF - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AU - Johnson, Michael Y1 - 2011/02/17/ PY - 2011 DA - 2011 Feb 17 KW - Developing countries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312946043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.atitle=NIH+Beyond+Research%3A+Strengthening+Work+Force+and+Institutions+in+Developing+Countries&rft.au=Johnson%2C+Michael&rft.aulast=Johnson&rft.aufirst=Michael&rft.date=2011-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://aaas.confex.com/aaas/2011/webprogram/start.html#srch=method|and|pge|1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - New Expectations for Individuals' Right-To-Know in Environmental Health Research T2 - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AN - 1312904590; 6045205 JF - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AU - Collman, Gwen Y1 - 2011/02/17/ PY - 2011 DA - 2011 Feb 17 KW - Environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312904590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.atitle=New+Expectations+for+Individuals%27+Right-To-Know+in+Environmental+Health+Research&rft.au=Collman%2C+Gwen&rft.aulast=Collman&rft.aufirst=Gwen&rft.date=2011-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://aaas.confex.com/aaas/2011/webprogram/start.html#srch=method|and|pge|1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Dendritic poly(ether imine) based gene delivery vector. AN - 852539880; 21192709 AB - The nonviral vector based gene delivery approach is attractive due to advantages associated with molecular-level modifications suitable for optimization of vector properties. In a new class of nonviral gene delivery systems, we herein report the potential of poly(ether imine) (PETIM) dendrimers to mediate an effective gene delivery function. PETIM dendrimer, constituted with tertiary amine branch points, n-propyl ether linkers and primary amines at their peripheries, exhibits significantly reduced toxicities, over a broad concentration range. The dendrimer complexes pDNA effectively, protects DNA from endosomal damages, and delivers to the cell nucleus. Gene transfection studies, utilizing a reporter plasmid pEGFP-C1 and upon complexation with dendrimer, showed a robust expression of the encoded protein. The study shows that PETIM dendrimers are hitherto unknown novel gene delivery vectors, combining features of poly(ethylene imine)-based polymers and dendrimers, yet are relatively nontoxic and structurally precise. JF - Bioconjugate chemistry AU - Thankappan, Ullas Padinjaremattathil AU - Madhusudana, Shampur Narayan AU - Desai, Anita AU - Jayamurugan, Govindasamy AU - Rajesh, Yamajala B R D AU - Jayaraman, Narayanaswamy AD - Department of Neurovirology, National Institute of Mental Health & Neurosciences, Bangalore 560029, India. Y1 - 2011/02/16/ PY - 2011 DA - 2011 Feb 16 SP - 115 EP - 119 VL - 22 IS - 2 KW - Dendrimers KW - 0 KW - Polymers KW - co(polyether-imide) KW - Index Medicus KW - Molecular Structure KW - Animals KW - Particle Size KW - Cell Line KW - Cricetinae KW - Cell Survival KW - Genetic Vectors -- chemistry KW - Dendrimers -- chemistry KW - Gene Transfer Techniques KW - Polymers -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/852539880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+chemistry&rft.atitle=Dendritic+poly%28ether+imine%29+based+gene+delivery+vector.&rft.au=Thankappan%2C+Ullas+Padinjaremattathil%3BMadhusudana%2C+Shampur+Narayan%3BDesai%2C+Anita%3BJayamurugan%2C+Govindasamy%3BRajesh%2C+Yamajala+B+R+D%3BJayaraman%2C+Narayanaswamy&rft.aulast=Thankappan&rft.aufirst=Ullas&rft.date=2011-02-16&rft.volume=22&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+chemistry&rft.issn=1520-4812&rft_id=info:doi/10.1021%2Fbc1003108 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-16 N1 - Date created - 2011-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/bc1003108 ER - TY - JOUR T1 - Synthesis and evaluation of new iRGD peptide analogs for tumor optical imaging AN - 907154149; 14355380 AB - Recently, a disulfide-based cyclic RGD peptide called iRGD, that is, c(CRGDKGPDC), has been reported to interact with both integrin and neuropilin-1 receptors for cellular and deep tissue penetration to improve the imaging sensitivity and therapeutic efficacy. In this study, two new near-infrared fluorescent iRGD conjugates, that is, Ac-Cys(IRDye[registered]800CW)-iRGD ( 1), and its dual labeling analog DOTA-Cys(IRDye[registered]800CW)-iRGD ( 2) were synthesized via the specific mercapto-maleimide reaction for tumor imaging. Both 1 and 2 showed significant tumor localization in optical imaging of MDA-MB-435 tumor-bearing mice. The potential of such iRGD compounds in tumor-targeted imaging and drug delivery deserves further exploration. JF - Bioorganic and Medicinal Chemistry Letters AU - Ye, Yunpeng AU - Zhu, Lei AU - Ma, Ying AU - Niu, Gang AU - Chen, Xiaoyuan AD - Laboratory of Molecular Imaging & Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA, shawn.chen@nih.gov Y1 - 2011/02/15/ PY - 2011 DA - 2011 Feb 15 SP - 1146 EP - 1150 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 21 IS - 4 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - I.R. radiation KW - Integrins KW - neuropilin KW - Computed tomography KW - Tumors KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907154149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Synthesis+and+evaluation+of+new+iRGD+peptide+analogs+for+tumor+optical+imaging&rft.au=Ye%2C+Yunpeng%3BZhu%2C+Lei%3BMa%2C+Ying%3BNiu%2C+Gang%3BChen%2C+Xiaoyuan&rft.aulast=Ye&rft.aufirst=Yunpeng&rft.date=2011-02-15&rft.volume=21&rft.issue=4&rft.spage=1146&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2010.12.112 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Drug delivery; I.R. radiation; Integrins; neuropilin; Computed tomography; Tumors DO - http://dx.doi.org/10.1016/j.bmcl.2010.12.112 ER - TY - JOUR T1 - The I Kappa B Family Member Bcl-3 Coordinates the Pulmonary Defense against Klebsiella pneumoniae Infection AN - 907152412; 14341135 AB - Bcl-3 is an atypical member of the I Kappa B family that has the potential to positively or negatively modulate nuclear NF- Kappa B activity in a context-dependent manner. Bcl-3's biologic impact is complex and includes roles in tumorigenesis and diverse immune responses, including innate immunity. Bcl-3 may mediate LPS tolerance, suppressing cytokine production, but it also seems to contribute to defense against select systemic bacterial challenges. However, the potential role of Bcl-3 in organ-specific host defense against bacteria has not been addressed. In this study, we investigated the relevance of Bcl-3 in a lung challenge with the Gram-negative pathogen Klebsiella pneumoniae. In contrast to wild-type mice, Bcl-3-deficient mice exhibited significantly increased susceptibility toward K. pneumoniae pneumonia. The mutant mice showed increased lung damage marked by neutrophilic alveolar consolidation, and they failed to clear bacteria in lungs, which correlated with increased bacteremic dissemination. Loss of Bcl-3 incurred a dramatic cytokine imbalance in the lungs, which was characterized by higher levels of IL-10 and a near total absence of IFN- gamma . Moreover, Bcl-3-deficient mice displayed increased lung production of the neutrophil-attracting chemokines CXCL-1 and CXCL-2. Alveolar macrophages and neutrophils are important to antibacterial lung defense. In vitro stimulation of Bcl-3-deficient alveolar macrophages with LPS or heat-killed K. pneumoniae recapitulated the increase in IL-10 production, and Bcl-3-deficient neutrophils were impaired in intracellular bacterial killing. These findings suggest that Bcl-3 is critically involved in lung defense against Gram-negative bacteria, modulating functions of several cells to facilitate efficient clearance of bacteria. JF - Journal of Immunology AU - Pene, Frederic AU - Paun, Andrea AU - Soender, Soeren Ulrik AU - Rikhi, Nimisha AU - Wang, Hongshan AU - Claudio, Estefania AU - Siebenlist, Ulrich AD - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2011/02/15/ PY - 2011 DA - 2011 Feb 15 SP - 2412 EP - 2421 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA VL - 186 IS - 4 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - gamma -Interferon KW - Chemokines KW - Tumorigenesis KW - Leukocytes (neutrophilic) KW - Bcl-3 protein KW - Immunity KW - Pathogens KW - Infection KW - Immunological tolerance KW - Interleukin 10 KW - Alveoli KW - NF- Kappa B protein KW - Lung KW - Gram-negative bacteria KW - Cytokines KW - Lipopolysaccharides KW - Immune response KW - Pneumonia KW - Klebsiella pneumoniae KW - F 06915:Cancer Immunology KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907152412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=The+I+Kappa+B+Family+Member+Bcl-3+Coordinates+the+Pulmonary+Defense+against+Klebsiella+pneumoniae+Infection&rft.au=Pene%2C+Frederic%3BPaun%2C+Andrea%3BSoender%2C+Soeren+Ulrik%3BRikhi%2C+Nimisha%3BWang%2C+Hongshan%3BClaudio%2C+Estefania%3BSiebenlist%2C+Ulrich&rft.aulast=Pene&rft.aufirst=Frederic&rft.date=2011-02-15&rft.volume=186&rft.issue=4&rft.spage=2412&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Macrophages; gamma -Interferon; Chemokines; Tumorigenesis; Bcl-3 protein; Leukocytes (neutrophilic); Pathogens; Immunity; Infection; Immunological tolerance; Alveoli; Interleukin 10; NF- Kappa B protein; Lung; Gram-negative bacteria; Lipopolysaccharides; Cytokines; Immune response; Pneumonia; Klebsiella pneumoniae ER - TY - JOUR T1 - Insertion of MicroRNA Targets into the Flavivirus Genome Alters Its Highly Neurovirulent Phenotype AN - 907148788; 14266696 AB - Flaviviruses such as West Nile, Japanese encephalitis, and tick-borne encephalitis (TBEV) viruses are important neurotropic human pathogens, causing a devastating and often fatal neuroinfection. Here, we demonstrate that incorporation into the viral genome of a target sequence for cellular microRNAs expressed in the central nervous system (CNS) enables alteration of the neurovirulence of the virus and control of the neuropathogenesis of flavivirus infection. As a model virus for this type of modification, we used a neurovirulent chimeric tick-borne encephalitis/dengue virus (TBEV/DEN4) that contained the structural protein genes of a highly pathogenic TBEV. The inclusion of just a single target copy for a brain tissue-expressed mir-9, mir-124a, mir-128a, mir-218, or let-7c microRNA into the TBEV/DEN4 genome was sufficient to prevent the development of otherwise lethal encephalitis in mice infected intracerebrally with a large dose of virus. Viruses bearing a complementary target for mir-9 or mir-124a were highly restricted in replication in primary neuronal cells, had limited access into the CNS of immunodeficient mice, and retained the ability to induce a strong humoral immune response in monkeys. This work suggests that microRNA targeting to control flavivirus tissue tropism and pathogenesis might represent a rational approach for virus attenuation and vaccine development. JF - Journal of Virology AU - Heiss, Brian L AU - Maximova, Olga A AU - Pletnev, Alexander G AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2011/02/15/ PY - 2011 DA - 2011 Feb 15 SP - 1464 EP - 1472 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 85 IS - 4 SN - 0022-538X, 0022-538X KW - Genetics Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Dengue virus KW - Genomes KW - Central nervous system KW - Nucleotide sequence KW - Viruses KW - Animal models KW - Immunodeficiency KW - Infection KW - Phenotypes KW - Flavivirus KW - Structural proteins KW - Tick-borne encephalitis KW - Immune response (humoral) KW - Replication KW - Tropism KW - miRNA KW - Neurovirulence KW - Neuropathogenesis KW - Brain KW - Pathogens KW - Encephalitis KW - Viral diseases KW - Insertion KW - Vaccines KW - V 22350:Immunology KW - Q1 08485:Species interactions: pests and control KW - N 14830:RNA KW - Q5 08524:Public health, medicines, dangerous organisms KW - G 07760:Viruses & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907148788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Insertion+of+MicroRNA+Targets+into+the+Flavivirus+Genome+Alters+Its+Highly+Neurovirulent+Phenotype&rft.au=Heiss%2C+Brian+L%3BMaximova%2C+Olga+A%3BPletnev%2C+Alexander+G&rft.aulast=Heiss&rft.aufirst=Brian&rft.date=2011-02-15&rft.volume=85&rft.issue=4&rft.spage=1464&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Genomes; Central nervous system; Viral diseases; Replication; Viruses; Brain; Vaccines; Pathogens; Phenotypes; Nucleotide sequence; miRNA; Tropism; Neuropathogenesis; Immunodeficiency; Animal models; Neurovirulence; Infection; Encephalitis; Structural proteins; Tick-borne encephalitis; Insertion; Immune response (humoral); Dengue virus; Flavivirus ER - TY - JOUR T1 - CD4 and CD8 T Cell Immune Activation during Chronic HIV Infection: Roles of Homeostasis, HIV, Type I IFN, and IL-7 AN - 904466461; 14341172 AB - Immune activation plays an important role in the pathogenesis of HIV disease. Although the causes are not fully understood, the forces that lead to immune dysfunction differ for CD4 and CD8 T cells. In this study, we report that the molecular pathways that drive immune activation during chronic HIV infection are influenced by differences in the homeostatic regulation of the CD4 and CD8 T cell pools. Proliferation of CD4 T cells is controlled more tightly by CD4 T cell numbers than is CD8 T cell proliferation. This difference reflects the importance of maintaining a polyclonal CD4 T cell pool in host surveillance. Both pools of T cells were found to be driven by viral load and its associated state of inflammation. In the setting of HIV-induced lymphopenia, naive CD4 T cells were recruited mainly into the proliferating pool in response to CD4 T cell depletion, whereas naive CD8 T cell proliferation was driven mainly by levels of HIV RNA. RNA analysis revealed increased expression of genes associated with type I IFN and common gamma chain cytokine signaling in CD4 T cell subsets and only type I IFN-associated genes in CD8 T cell subsets. In vitro studies demonstrated enhanced STAT1 phosphorylation in response to IFN- alpha and increased expression of the IFNAR1 transcripts in naive and memory CD4 T cells compared with that observed in CD8 T cells. CD4 T cell subsets also showed enhanced STAT1 phosphorylation in response to exogenous IL-7. JF - Journal of Immunology AU - Catalfamo, Marta AU - Wilhelm, Christopher AU - Tcheung, Lueng AU - Proschan, Michael AU - Friesen, Travis AU - Park, Jung-Hyun AU - Adelsberger, Joseph AU - Baseler, Michael AU - Maldarelli, Frank AU - Davey, Richard AU - Roby, Gregg AU - Rehm, Catherine AU - Lane, Clifford AD - Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2011/02/15/ PY - 2011 DA - 2011 Feb 15 SP - 2106 EP - 2116 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA VL - 186 IS - 4 SN - 0022-1767, 0022-1767 KW - Virology & AIDS Abstracts; Toxicology Abstracts; Immunology Abstracts KW - Interleukin 7 KW - Memory cells KW - Lymphopenia KW - Immunological memory KW - CD8 antigen KW - Homeostasis KW - Inflammation KW - Interferon KW - CD4 antigen KW - RNA KW - Phosphorylation KW - Human immunodeficiency virus KW - Stat1 protein KW - alpha -Interferon KW - Chronic infection KW - Lymphocytes T KW - Cytokines KW - Cell proliferation KW - Signal transduction KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904466461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=CD4+and+CD8+T+Cell+Immune+Activation+during+Chronic+HIV+Infection%3A+Roles+of+Homeostasis%2C+HIV%2C+Type+I+IFN%2C+and+IL-7&rft.au=Catalfamo%2C+Marta%3BWilhelm%2C+Christopher%3BTcheung%2C+Lueng%3BProschan%2C+Michael%3BFriesen%2C+Travis%3BPark%2C+Jung-Hyun%3BAdelsberger%2C+Joseph%3BBaseler%2C+Michael%3BMaldarelli%2C+Frank%3BDavey%2C+Richard%3BRoby%2C+Gregg%3BRehm%2C+Catherine%3BLane%2C+Clifford&rft.aulast=Catalfamo&rft.aufirst=Marta&rft.date=2011-02-15&rft.volume=186&rft.issue=4&rft.spage=2106&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Interleukin 7; Immunological memory; Lymphopenia; Memory cells; Homeostasis; CD8 antigen; Inflammation; Interferon; CD4 antigen; Phosphorylation; RNA; Stat1 protein; Chronic infection; alpha -Interferon; Lymphocytes T; Cytokines; Cell proliferation; Signal transduction; Human immunodeficiency virus ER - TY - JOUR T1 - Target-cancer-cell-specific activatable fluorescence imaging probes: rational design and in vivo applications. AN - 851934291; 21062101 AB - Conventional imaging methods, such as angiography, computed tomography (CT), magnetic resonance imaging (MRI), and radionuclide imaging, rely on contrast agents (iodine, gadolinium, and radioisotopes, for example) that are "always on." Although these indicators have proven clinically useful, their sensitivity is lacking because of inadequate target-to-background signal ratio. A unique aspect of optical imaging is that fluorescence probes can be designed to be activatable, that is, only "turned on" under certain conditions. These probes are engineered to emit signal only after binding a target tissue; this design greatly increases sensitivity and specificity in the detection of disease. Current research focuses on two basic types of activatable fluorescence probes. The first developed were conventional enzymatically activatable probes. These fluorescent molecules exist in the quenched state until activated by enzymatic cleavage, which occurs mostly outside of the cells. However, more recently, researchers have begun designing target-cell-specific activatable probes. These fluorophores exist in the quenched state until activated within targeted cells by endolysosomal processing, which results when the probe binds specific receptors on the cell surface and is subsequently internalized. In this Account, we present a review of the rational design and in vivo applications of target-cell-specific activatable probes. In engineering these probes, researchers have asserted control over a variety of factors, including photochemistry, pharmacological profile, and biological properties. Their progress has recently allowed the rational design and synthesis of target-cell-specific activatable fluorescence imaging probes, which can be conjugated to a wide variety of targeting molecules. Several different photochemical mechanisms have been utilized, each of which offers a unique capability for probe design. These include self-quenching, homo- and hetero-fluorescence resonance energy transfer (FRET), H-dimer formation, and photon-induced electron transfer (PeT). In addition, the repertoire is further expanded by the option for reversibility or irreversibility of the signal emitted through these mechanisms. Given the wide range of photochemical mechanisms and properties, target-cell-specific activatable probes have considerable flexibility and can be adapted to specific diagnostic needs. A multitude of cell surface molecules, such as overexpressed growth factor receptors, are directly related to carcinogenesis and thus provide numerous targets highly specific for cancer. This discussion of the chemical, pharmacological, and biological basis of target-cell-specific activatable imaging probes, and methods for successfully designing them, underscores the systematic, rational basis for further developing in vivo cancer imaging. JF - Accounts of chemical research AU - Kobayashi, Hisataka AU - Choyke, Peter L AD - National Institutes of Health, Bethesda, Maryland 20892-1088, USA. Kobayash@mail.nih.gov Y1 - 2011/02/15/ PY - 2011 DA - 2011 Feb 15 SP - 83 EP - 90 VL - 44 IS - 2 KW - Fluorescent Dyes KW - 0 KW - Index Medicus KW - Animals KW - Spectrometry, Fluorescence KW - Humans KW - Photochemical Processes KW - Fluorescent Dyes -- metabolism KW - Neoplasms -- pathology KW - Molecular Imaging -- methods KW - Fluorescent Dyes -- chemistry KW - Drug Design KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/851934291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Accounts+of+chemical+research&rft.atitle=Target-cancer-cell-specific+activatable+fluorescence+imaging+probes%3A+rational+design+and+in+vivo+applications.&rft.au=Kobayashi%2C+Hisataka%3BChoyke%2C+Peter+L&rft.aulast=Kobayashi&rft.aufirst=Hisataka&rft.date=2011-02-15&rft.volume=44&rft.issue=2&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Accounts+of+chemical+research&rft.issn=1520-4898&rft_id=info:doi/10.1021%2Far1000633 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-13 N1 - Date created - 2011-02-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Radiology. 1999 Dec;213(3):866-70 [10580968] Nat Biotechnol. 2000 Mar;18(3):321-5 [10700150] Angew Chem Int Ed Engl. 2002 Nov 15;41(22):4334-6 [12434381] Nat Biotechnol. 1999 Apr;17(4):375-8 [10207887] Bioconjug Chem. 1999 Sep-Oct;10(5):892-6 [10502358] J Am Chem Soc. 2005 Apr 6;127(13):4888-94 [15796553] Nat Biotechnol. 2005 Sep;23(9):1137-46 [16151407] Cancer Res. 2007 Mar 15;67(6):2791-9 [17363601] Clin Cancer Res. 2007 Nov 1;13(21):6335-43 [17975145] Nature. 2008 Apr 3;452(7187):580-9 [18385732] Nat Med. 2009 Jan;15(1):104-9 [19029979] Mol Cancer Ther. 2009 Jan;8(1):232-9 [19139133] Cancer Res. 2009 Feb 15;69(4):1268-72 [19176373] ACS Chem Biol. 2009 Jul 17;4(7):535-46 [19480464] Mol Pharm. 2009 Mar-Apr;6(2):386-95 [19718793] Mol Biosyst. 2009 Nov;5(11):1279-91 [19823742] Chem Rev. 2010 May 12;110(5):2620-40 [20000749] Mol Biosyst. 2010 May;6(5):888-93 [20567775] Nat Biotechnol. 2001 Apr;19(4):316-7 [11283581] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ar1000633 ER - TY - JOUR T1 - Prefrontal cortical abnormalities in currently depressed versus currently remitted patients with major depressive disorder AN - 954616112; 14257355 AB - Previous neuromorphometric investigations of major depressive disorder (MDD) have reported abnormalities in gray matter in several regions, although the results have been inconsistent across studies. Some discrepancies in the results across studies may reflect design limitations such as small sample sizes, whereas others may reflect biological variability that potentially manifests as differences in clinical course. For example, it remains unclear whether the abnormalities found in persistently depressed MDD subjects extend to or persist in patients who experience prolonged remission. The aim of the present study was to investigate gray matter (GM) differences in unmedicated, currently-depressed participants (dMDD) and unmedicated, currently-remitted (rMDD) participants with MDD compared to healthy controls (HC). The GM density and volume were compared across groups using voxel-based morphometry, a quantitative neuroanatomical technique, and high-resolution MRI images from 107 HC, 58 dMDD and 27 rMDD subjects. Relative to the HC group the dMDD group had reduced GM in the dorsal anterolateral (DALPFC), the dorsomedial (DMPFC) and the ventrolateral prefrontal cortex (VLPFC). Relative to the rMDD group the dMDD group showed reduced GM in the DALPFC, the VLPFC, the anterior cingulate cortex (ACC), the precuneus and the inferior parietal lobule. No regions were identified in which the rMDD group showed significantly lower GM compared to the HC group after p-values were corrected for the number of comparisons performed. In unmedicated patients in the depressed phase of MDD, we found evidence of morphometric abnormalities in DALPFC and in medial prefrontal cortical regions belonging to the visceromotor network. These findings, along with the absence of GM abnormalities in the remitted sample imply a possible link between greater GM tissue and better clinical outcome. Consistent with other neuroimaging and post-mortem neuropathological studies of MDD, we also found evidence of decreased white matter in patients with dMDD and rMDD. JF - NeuroImage AU - Salvadore, Giacomo AU - Nugent, Allison C AU - Lemaitre, Herve AU - Luckenbaugh, David A AU - Tinsley, Ruth AU - Cannon, Dara M AU - Neumeister, Alexander AU - Zarate, Carlos A AU - Drevets, Wayne C AD - Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA, salvadoreg@mail.nih.gov Y1 - 2011/02/14/ PY - 2011 DA - 2011 Feb 14 SP - 2643 EP - 2651 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 54 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Anatomy KW - Depression KW - W 30910:Imaging KW - N3:11027 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954616112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Prefrontal+cortical+abnormalities+in+currently+depressed+versus+currently+remitted+patients+with+major+depressive+disorder&rft.au=Salvadore%2C+Giacomo%3BNugent%2C+Allison+C%3BLemaitre%2C+Herve%3BLuckenbaugh%2C+David+A%3BTinsley%2C+Ruth%3BCannon%2C+Dara+M%3BNeumeister%2C+Alexander%3BZarate%2C+Carlos+A%3BDrevets%2C+Wayne+C&rft.aulast=Salvadore&rft.aufirst=Giacomo&rft.date=2011-02-14&rft.volume=54&rft.issue=4&rft.spage=2643&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.11.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Depression DO - http://dx.doi.org/10.1016/j.neuroimage.2010.11.011 ER - TY - JOUR T1 - Improving contrast to noise ratio of resonance frequency contrast images (phase images) using balanced steady-state free precession AN - 899135270; 14257368 AB - Recent MRI studies have exploited subtle magnetic susceptibility differences between brain tissues to improve anatomical contrast and resolution. These susceptibility differences lead to resonance frequency shifts which can be visualized by reconstructing the signal phase in conventional gradient echo (GRE) acquisition techniques. In this work, a method is proposed to improve the contrast to noise ratio per unit time (CNR efficiency) of anatomical MRI based on resonance frequency contrast. The method, based on the balanced steady-state free precession (bSSFP) MRI acquisition technique, was evaluated in its ability to generate contrast between gray and white matter in human brain at 3 T and 7 T. The results show substantially improved CNR efficiency of bSSFP phase images (2.85 +/- 0.21 times at 3 T and 1.71 +/- 0.11 times at 7 T) compared to the GRE data in a limited spatial area. This limited spatial coverage is attributed to the sensitivity of bSSFP to macroscopic B sub(0) inhomogeneities. With this CNR improvement, high resolution bSSFP phase images (resolution = 0.3 x 0.3 x 2 mm super(3), acquisition time = 10 min) acquired at 3 T had sufficient CNR to allow the visualization of cortical laminar structures in in vivo human primary visual cortex. Practical application of the proposed method may require improvement of B sub(0) homogeneity and stability by additional preparatory scans and/or compensation schemes such as respiration and drift compensation. Without these additions, the CNR benefits of the method may be limited to studies at low field or limited regions of interest. JF - NeuroImage AU - Lee, Jongho AU - Fukunaga, Masaki AU - Duyn, Jeff H AD - Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA Y1 - 2011/02/14/ PY - 2011 DA - 2011 Feb 14 SP - 2779 EP - 2788 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 54 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Ultra high field MRI KW - MR microscopy KW - Balanced SSFP and GRE sequence comparison KW - 7 Tesla KW - Neuroimaging KW - Data processing KW - Cortex (visual) KW - Drift KW - Respiration KW - Magnetic resonance imaging KW - Brain KW - Substantia alba KW - Image processing KW - Magnetic susceptibility KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899135270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Improving+contrast+to+noise+ratio+of+resonance+frequency+contrast+images+%28phase+images%29+using+balanced+steady-state+free+precession&rft.au=Lee%2C+Jongho%3BFukunaga%2C+Masaki%3BDuyn%2C+Jeff+H&rft.aulast=Lee&rft.aufirst=Jongho&rft.date=2011-02-14&rft.volume=54&rft.issue=4&rft.spage=2779&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.10.071 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Data processing; Drift; Cortex (visual); Respiration; Magnetic resonance imaging; Brain; Magnetic susceptibility; Image processing; Substantia alba DO - http://dx.doi.org/10.1016/j.neuroimage.2010.10.071 ER - TY - JOUR T1 - Methylphenidate enhances brain activation and deactivation responses to visual attention and working memory tasks in healthy controls AN - 860375638; 14257397 AB - Methylphenidate (MPH) is a stimulant drug that amplifies dopamineric and noradrenergic signaling in the brain, which is believed to underlie its cognition enhancing effects. However, the neurobiological effects by which MPH improves cognition are still poorly understood. Here, functional magnetic resonance imaging (fMRI) was used together with working memory (WM) and visual attention (VA) tasks to test the hypothesis that 20 mg oral MPH would increase activation in the dorsal attention network (DAN) and deactivation in the default mode network (DMN) as well as improve performance during cognitive tasks in healthy men. The group of subjects that received MPH (MPH group; N = 16) had higher activation than the group of subjects who received no medication (control group: N = 16) in DAN regions (parietal and prefrontal cortex, regions increasingly activated with increased cognitive load) and had increased deactivation in the insula and posterior cingulate cortex (regions increasingly deactivated with increased cognitive load) and these effects did not differ for the VA and the WM tasks. These findings provide the first evidence that MPH enhances activation of the DAN whereas it alters DMN deactivation. This suggests that MPH (presumably by amplifying dopamine and noradrenergic signaling) modulates cognition in part through its effects on DAN and DMN. JF - NeuroImage AU - Tomasi, D AU - Volkow, N D AU - Wang, G J AU - Wang, R AU - Telang, F AU - Caparelli, E C AU - Wong, C AU - Jayne, M AU - Fowler, J S AD - National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA, tomasi@bnl.gov Y1 - 2011/02/14/ PY - 2011 DA - 2011 Feb 14 SP - 3101 EP - 3110 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 54 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Attention KW - Deactivation KW - W 30910:Imaging KW - N3:11001 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860375638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Methylphenidate+enhances+brain+activation+and+deactivation+responses+to+visual+attention+and+working+memory+tasks+in+healthy+controls&rft.au=Tomasi%2C+D%3BVolkow%2C+N+D%3BWang%2C+G+J%3BWang%2C+R%3BTelang%2C+F%3BCaparelli%2C+E+C%3BWong%2C+C%3BJayne%2C+M%3BFowler%2C+J+S&rft.aulast=Tomasi&rft.aufirst=D&rft.date=2011-02-14&rft.volume=54&rft.issue=4&rft.spage=3101&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.10.060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Deactivation DO - http://dx.doi.org/10.1016/j.neuroimage.2010.10.060 ER - TY - JOUR T1 - Physiological noise effects on the flip angle selection in BOLD fMRI AN - 851470767; 14257367 AB - This work addresses the choice of imaging flip angle in blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI). When noise of physiological origin becomes the dominant noise source in fMRI timeseries, it causes a nonlinear dependence of the temporal signal-to-noise ratio (TSNR) versus signal-to-noise ratio (SNR) that can be exploited to perform BOLD fMRI at angles well below the Ernst angle without any detrimental effect on our ability to detect sites of neuronal activation. We show, both experimentally and theoretically, that for situations where available SNR is high and physiological noise dominates over system/thermal noise, although TSNR still reaches it maximum for the Ernst angle, reduction of imaging flip angle well below this angle results in negligible loss in TSNR. Moreover, we provide a way to compute a suggested imaging flip angle, which constitutes a conservative estimate of the minimum flip angle that can be used under given experimental SNR and physiological noise levels. For our experimental conditions, this suggested angle equals 7.63 degree for the grey matter compartment, while the Ernst angle = 77 degree . Finally, using data from eight subjects with a combined visual-motor task we show that imaging at angles as low as 9 degree introduces no significant differences in observed hemodynamic response time-course, contrast-to-noise ratio, voxel-wise effect size or statistical maps of activation as compared to imaging at 75 degree (an angle close to the Ernst angle). These results suggest that using low flip angles in BOLD fMRI experimentation to obtain benefits such as (1) reduction of RF power, (2) limitation of apparent T sub(1)-related inflow effects, (3) reduction of through-plane motion artifacts, (4) lower levels of physiological noise, and (5) improved tissue contrast is feasible when physiological noise dominates and SNR is high. JF - NeuroImage AU - Gonzalez-Castillo, J AU - Roopchansingh, V AU - Bandettini, P A AU - Bodurka, J AD - Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, 10 Center Dr, Bethesda, MD 20892, USA, javier.gonzalez-castillo@nih.gov Y1 - 2011/02/14/ PY - 2011 DA - 2011 Feb 14 SP - 2764 EP - 2778 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 54 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Data processing KW - Functional magnetic resonance imaging KW - W 30910:Imaging KW - N3:11029 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/851470767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Physiological+noise+effects+on+the+flip+angle+selection+in+BOLD+fMRI&rft.au=Gonzalez-Castillo%2C+J%3BRoopchansingh%2C+V%3BBandettini%2C+P+A%3BBodurka%2C+J&rft.aulast=Gonzalez-Castillo&rft.aufirst=J&rft.date=2011-02-14&rft.volume=54&rft.issue=4&rft.spage=2764&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.11.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2010.11.020 ER - TY - JOUR T1 - Identification of Nuclear Localization, DNA Binding, and Transactivating Mechanisms of Krueppel-like Zinc Finger Protein Gli-Similar 2 (Glis2) AN - 907150281; 14340846 AB - Gli-similar 1-3 (Glis1-3) constitute a subfamily of Krueppel-like zinc finger (ZF) transcription factors that are closely related to the Gli protein family. Mutations in GLIS2 are linked to nephronophthisis, a chronic kidney disease characterized by renal fibrosis and atrophy in children and young adults. Currently, very little information exists about the mechanism of action of Glis2, its target genes, or the signaling pathways that regulate its activity. In this study, we show that a region within ZF3 is required for the nuclear localization of Glis2. Analysis of Glis2 DNA binding demonstrated that Glis2 binds effectively to the consensus Glis binding sequence (GlisBS) (G/C)TGGGGGGT(A/C). Although Glis2 was unable to induce transactivation of a GlisBS-dependent reporter, it effectively inhibited the GlisBS-mediated transactivation by Gli1. Mutations that disrupt the tetrahedral configuration of each ZF within Glis2 abolished Glis2 binding to GlisBS and also abrogated its inhibition of Gli1-mediated transactivation. In contrast, Glis2 was able to activate the murine insulin-2 (Ins2) promoter by binding directly to two GlisBS elements located at -263 and -99 within the Ins2 promoter. Phosphomimetic mutation of Ser245 inhibited the binding of Glis2 to GlisBS and dramatically affected its transactivation of the Ins2 promoter and its ability to inhibit GlisBS-dependent transactivation by Gli1. In this study, we demonstrate that Glis2 can function as a transcriptional activator and that post-translational modification within its DNA-binding domain can regulate its transcriptional activity. This control may play a critical role in the Glis2-dependent regulation of target genes and renal function. JF - Journal of Biological Chemistry AU - Vasanth, Shivakumar AU - ZeRuth, Gary AU - Kang, Hong Soon AU - Jetten, Anton M AD - From the Cell Biology Section, Division of Intramural Research, Laboratory of Respiratory Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709 Y1 - 2011/02/11/ PY - 2011 DA - 2011 Feb 11 SP - 4749 EP - 4759 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 286 IS - 6 SN - 0021-9258, 0021-9258 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Atrophy KW - Children KW - Conserved sequence KW - DNA KW - DNA-binding protein KW - Fibrosis KW - Gene regulation KW - Gli protein KW - Kidney diseases KW - Mutation KW - Nephronophthisis KW - Nucleotide sequence KW - Post-translation KW - Promoters KW - Renal function KW - Signal transduction KW - Transcription KW - Transcription factors KW - Zinc finger proteins KW - N 14835:Protein-Nucleic Acids Association KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907150281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Identification+of+Nuclear+Localization%2C+DNA+Binding%2C+and+Transactivating+Mechanisms+of+Krueppel-like+Zinc+Finger+Protein+Gli-Similar+2+%28Glis2%29&rft.au=Vasanth%2C+Shivakumar%3BZeRuth%2C+Gary%3BKang%2C+Hong+Soon%3BJetten%2C+Anton+M&rft.aulast=Vasanth&rft.aufirst=Shivakumar&rft.date=2011-02-11&rft.volume=286&rft.issue=6&rft.spage=4749&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-03-11 N1 - SubjectsTermNotLitGenreText - Fibrosis; Nephronophthisis; DNA-binding protein; Nucleotide sequence; Kidney diseases; Transcription; Zinc finger proteins; Children; Gli protein; Promoters; Renal function; Post-translation; Gene regulation; Transcription factors; DNA; Conserved sequence; Atrophy; Mutation; Signal transduction ER - TY - JOUR T1 - Maternal, neonatal, and child health in southeast Asia: towards greater regional collaboration AN - 856779772; 14357223 AB - Although maternal and child mortality are on the decline in southeast Asia, there are still major disparities, and greater equity is key to achieve the Millennium Development Goals. We used comparable cross-national data sources to document mortality trends from 1990 to 2008 and to assess major causes of maternal and child deaths. We present inequalities in intervention coverage by two common measures of wealth quintiles and rural or urban status. Case studies of reduction in mortality in Thailand and Indonesia indicate the varying extents of success and point to some factors that accelerate progress. We developed a Lives Saved Tool analysis for the region and for country subgroups to estimate deaths averted by cause and intervention. We identified three major patterns of maternal and child mortality reduction: early, rapid downward trends (Brunei, Singapore, Malaysia, and Thailand); initially high declines (sustained by Vietnam but faltering in the Philippines and Indonesia); and high initial rates with a downward trend (Laos, Cambodia, and Myanmar). Economic development seems to provide an important context that should be coupled with broader health-system interventions. Increasing coverage and consideration of the health-system context is needed, and regional support from the Association of Southeast Asian Nations can provide increased policy support to achieve maternal, neonatal, and child health goals. JF - Lancet AU - Acuin, Cecilia S AU - Khor, Geok Lin AU - Liabsuetrakul, Tippawan AU - Achadi, Endang L AU - Htay, Thein Thein AU - Firestone, Rebecca AU - Bhutta, Zulfiqar A AD - Institute of Clinical Epidemiology, University of the Philippines, National Institutes of Health, Ermita, Manila, Philippines, cesacuin@gmail.com Y1 - 2011/02/11/ PY - 2011 DA - 2011 Feb 11 SP - 516 EP - 525 PB - The Lancet Ltd., 655 Ave. of the Americas New York NY 10011 USA VL - 377 IS - 9764 SN - 0140-6736, 0140-6736 KW - Aqualine Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856779772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Maternal%2C+neonatal%2C+and+child+health+in+southeast+Asia%3A+towards+greater+regional+collaboration&rft.au=Acuin%2C+Cecilia+S%3BKhor%2C+Geok+Lin%3BLiabsuetrakul%2C+Tippawan%3BAchadi%2C+Endang+L%3BHtay%2C+Thein+Thein%3BFirestone%2C+Rebecca%3BBhutta%2C+Zulfiqar+A&rft.aulast=Acuin&rft.aufirst=Cecilia&rft.date=2011-02-11&rft.volume=377&rft.issue=9764&rft.spage=516&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=01406736&rft_id=info:doi/10.1016%2FS0140-6736%2810%2962049-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1016/S0140-6736(10)62049-1 ER - TY - JOUR T1 - Differential glucocorticoid receptor-mediated transcription mechanisms. AN - 850560975; 21127044 AB - Nuclear receptors such as the glucocorticoid receptor (GR) are ligand-dependent transcription factors that mediate transcription of target genes by recruiting factors that modulate chromatin structure. In this study, curcumin, a compound known to inhibit GR-mediated transcription, was used to examine the different mechanisms by which GR regulates transcription. The mechanisms of transcription regulation of metallothioneine-2A (MT2A) and solute carrier family 19 member 2 (SLC19A2), two GR target genes where the hormone-dependent gene activation is inhibited or unaffected by curcumin treatment, respectively, were analyzed by chromatin immunoprecipitation and RT-PCR experiments. The data suggest that the loss of hormone-dependent MT2A gene expression is due to the inhibition of continued transcription activity after initial assembly of the transcription machinery. In contrast, the hormone-dependent SLC19A2 gene expression is maintained because the continued transcription output after assembly of transcription machinery is unaffected by curcumin. These results suggest that the two GR target genes use alternate mechanisms to regulate expression levels at the level of continued transcription output after transcription machinery assembly. JF - The Journal of biological chemistry AU - Aoyagi, Sayura AU - Archer, Trevor K AD - Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2011/02/11/ PY - 2011 DA - 2011 Feb 11 SP - 4610 EP - 4619 VL - 286 IS - 6 KW - Enzyme Inhibitors KW - 0 KW - MT2A protein, human KW - Membrane Transport Proteins KW - Receptors, Glucocorticoid KW - SLC19A2 protein, human KW - Metallothionein KW - 9038-94-2 KW - Curcumin KW - IT942ZTH98 KW - Index Medicus KW - HeLa Cells KW - Humans KW - Enzyme Inhibitors -- pharmacology KW - Curcumin -- pharmacology KW - Transcription, Genetic -- drug effects KW - Metallothionein -- biosynthesis KW - Gene Expression Regulation -- physiology KW - Receptors, Glucocorticoid -- antagonists & inhibitors KW - Membrane Transport Proteins -- biosynthesis KW - Gene Expression Regulation -- drug effects KW - Receptors, Glucocorticoid -- metabolism KW - Transcription, Genetic -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/850560975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Differential+glucocorticoid+receptor-mediated+transcription+mechanisms.&rft.au=Aoyagi%2C+Sayura%3BArcher%2C+Trevor+K&rft.aulast=Aoyagi&rft.aufirst=Sayura&rft.date=2011-02-11&rft.volume=286&rft.issue=6&rft.spage=4610&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M110.195040 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-24 N1 - Date created - 2011-02-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 1998 Mar 2;17(5):1454-66 [9482742] Science. 2008 Mar 28;319(5871):1791-2 [18369138] Mol Endocrinol. 2005 Jun;19(6):1429-38 [15914712] Nature. 2005 Aug 11;436(7052):876-80 [15988478] Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11651-6 [16087863] Mol Endocrinol. 2006 Mar;20(3):560-72 [16239257] Biochem J. 2006 Apr 15;395(2):405-15 [16402917] Genes Dev. 2006 Jun 1;20(11):1405-28 [16751179] Nat Genet. 2006 Nov;38(11):1289-97 [17013392] Mol Cell Endocrinol. 2007 Feb;265-266:162-7 [17240047] Mol Endocrinol. 2007 Apr;21(4):843-56 [17227884] Arch Biochem Biophys. 2007 Jul 15;463(2):201-10 [17462582] Cell. 2007 Jul 13;130(1):77-88 [17632057] Nat Genet. 2007 Dec;39(12):1512-6 [17994019] Nat Genet. 2007 Dec;39(12):1507-11 [17994021] Mol Cell Biol. 2008 Jan;28(1):30-9 [17954562] Environ Mol Mutagen. 2008 Jan;49(1):83-95 [18095329] Mol Cell. 2008 Mar 14;29(5):611-24 [18342607] Mol Endocrinol. 2008 Aug;22(8):1754-66 [18483179] Toxicol Lett. 2008 Oct 1;181(3):190-5 [18755257] Mol Endocrinol. 2008 Nov;22(11):2393-406 [18818283] Mol Cell Biol. 2009 Mar;29(5):1123-33 [19103744] Genome Res. 2009 Mar;19(3):372-80 [19129543] Endocrinology. 2009 Apr;150(4):1766-74 [19131569] Mol Cell. 2009 Sep 24;35(6):741-53 [19782025] PLoS Biol. 2009 Oct;7(10):e1000220 [19841728] Cancer Res. 2009 Nov 1;69(21):8217-22 [19843848] Trends Endocrinol Metab. 2010 Jan;21(1):3-9 [19800253] Annu Rev Physiol. 2010;72:191-218 [20148673] Trends Genet. 2010 May;26(5):214-20 [20381190] Nat Rev Genet. 2010 Jun;11(6):426-37 [20421872] Nat Struct Mol Biol. 2010 Jun;17(6):753-60 [20453859] Mol Endocrinol. 1995 Dec;9(12):1825-34 [8614418] Mol Cell Biol. 1994 Jan;14(1):32-41 [8264599] EMBO J. 1994 Jun 15;13(12):2870-5 [8026472] Genes Dev. 1995 Jun 1;9(11):1366-76 [7797076] Cell. 1995 Dec 15;83(6):835-9 [8521507] Eur J Biochem. 1999 Feb;259(3):635-42 [10092847] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M110.195040 ER - TY - JOUR T1 - Charting a course for genomic medicine from base pairs to bedside AN - 852753304; 21307933 AB - There has been much progress in genomics in the ten years since a draft sequence of the human genome was published. Opportunities for understanding health and disease are now unprecedented, as advances in genomics are harnessed to obtain robust foundational knowledge about the structure and function of the human genome and about the genetic contributions to human health and disease. Here we articulate a 2011 vision for the future of genomics research and describe the path towards an era of genomic medicine. [PUBLICATION ABSTRACT] JF - Nature AU - Green, Eric D AU - Guyer, Mark S Y1 - 2011/02/10/ PY - 2011 DA - 2011 Feb 10 SP - 204 EP - 13 CY - London PB - Nature Publishing Group VL - 470 IS - 7333 SN - 00280836 KW - Environmental Studies KW - Genomics KW - Genetics KW - Medicine KW - Studies KW - Cancer therapies KW - Biomedical research KW - Biology KW - Base Pairing KW - Human Genome Project KW - Humans KW - Genomics -- education KW - Genetic Predisposition to Disease KW - Genetics, Medical -- education KW - Genetic Counseling KW - Genome, Human -- genetics KW - Genetics, Medical -- trends KW - Genomics -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/852753304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Charting+a+course+for+genomic+medicine+from+base+pairs+to+bedside&rft.au=Green%2C+Eric+D%3BGuyer%2C+Mark+S&rft.aulast=Green&rft.aufirst=Eric&rft.date=2011-02-10&rft.volume=470&rft.issue=7333&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright Nature Publishing Group Feb 10, 2011 N1 - Document feature - Photographs; Graphs; References N1 - Last updated - 2014-04-02 N1 - CODEN - NATUAS ER - TY - JOUR T1 - The normal mammary microenvironment suppresses the tumorigenic phenotype of mouse mammary tumor virus-neu-transformed mammary tumor cells. AN - 851475801; 20890308 AB - The microenvironment of the mammary gland has been shown to exert a deterministic control over cells from different normal organs during murine mammary gland regeneration in transplantation studies. When mouse mammary tumor virus (MMTV)-neu-induced tumor cells were mixed with normal mammary epithelial cells (MECs) in a dilution series and inoculated into epithelium-free mammary fat pads, they were redirected to non-carcinogenic cell fates by interaction with untransformed MECs during regenerative growth. In the presence of non-transformed MECs (50:1), tumor cells interacted with MECs to generate functional chimeric outgrowths. When injected alone, tumor cells invariably produced tumors. Here, the normal microenvironment redirects MMTV-neu-transformed tumorigenic cells to participate in the regeneration of a normal, functional mammary gland. In addition, the redirected tumor cells show the capacity to differentiate into normal mammary cell types, including luminal, myoepithelial and secretory. The results indicate that signals emanating from a normal mammary microenvironment, comprised of stromal, epithelial and host-mediated signals, combine to suppress the cancer phenotype during glandular regeneration. Clarification of these signals offers improved therapeutic possibilities for the control of mammary cancer growth. JF - Oncogene AU - Booth, B W AU - Boulanger, C A AU - Anderson, L H AU - Smith, G H AD - Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2011/02/10/ PY - 2011 DA - 2011 Feb 10 SP - 679 EP - 689 VL - 30 IS - 6 KW - Index Medicus KW - Epithelial Cells -- virology KW - Animals KW - Epithelial Cells -- pathology KW - Adipose Tissue -- virology KW - Mice, Inbred C57BL KW - Cell Differentiation KW - Mice KW - Cell Line, Tumor KW - Mice, Transgenic KW - Female KW - Tumor Virus Infections -- virology KW - Tumor Microenvironment KW - Mammary Tumor Virus, Mouse KW - Mammary Glands, Animal -- growth & development KW - Mammary Neoplasms, Experimental -- virology KW - Mammary Neoplasms, Experimental -- pathology KW - Carcinoma -- virology KW - Retroviridae Infections -- virology KW - Carcinoma -- pathology KW - Mammary Glands, Animal -- virology KW - Mammary Glands, Animal -- pathology KW - Tumor Virus Infections -- pathology KW - Cell Transformation, Viral KW - Retroviridae Infections -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/851475801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=The+normal+mammary+microenvironment+suppresses+the+tumorigenic+phenotype+of+mouse+mammary+tumor+virus-neu-transformed+mammary+tumor+cells.&rft.au=Booth%2C+B+W%3BBoulanger%2C+C+A%3BAnderson%2C+L+H%3BSmith%2C+G+H&rft.aulast=Booth&rft.aufirst=B&rft.date=2011-02-10&rft.volume=30&rft.issue=6&rft.spage=679&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2010.439 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-04-08 N1 - Date created - 2011-02-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2004 Sep 9;23(41):6980-5 [15286714] Cancer Cell. 2002 Dec;2(6):451-61 [12498714] Proc Natl Acad Sci U S A. 1976 Feb;73(2):549-53 [1061157] Nature. 1984 Jun 7-13;309(5968):552-6 [6203040] Proc Natl Acad Sci U S A. 1986 Oct;83(19):7307-10 [3463969] Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10578-82 [1359541] J Biol Chem. 1996 Mar 29;271(13):7673-8 [8631805] Nucleic Acids Res. 1997 Nov 1;25(21):4323-30 [9336464] Development. 1998 May;125(10):1921-30 [9550724] Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5076-81 [9560231] Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15333-8 [9860969] EMBO J. 1999 Apr 15;18(8):2149-64 [10205169] Cancer Res. 1959 Jun;19(5):515-20 [13663040] Oncogene. 2005 Jan 20;24(4):552-60 [15580303] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2196-201 [16452162] CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66 [17237035] Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3871-6 [17360445] Mol Cancer Ther. 2007 Nov;6(11):2828-42 [17989321] Breast Cancer Res. 2008;10(1):203 [18304381] Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14891-6 [18809919] Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15637-8 [18843110] Cancer Cell. 2010 Jan 19;17(1):65-76 [20129248] Science. 1987 Jan 9;235(4785):177-82 [3798106] Cell. 1988 Jul 1;54(1):105-15 [2898299] Science. 1989 May 12;244(4905):707-12 [2470152] Cell. 1989 Jun 16;57(6):931-6 [2567634] Mol Cell Biol. 1992 Mar;12(3):954-61 [1312220] Oncogene. 2000 Feb 21;19(8):968-88 [10713680] Endocrinology. 2000 Aug;141(8):2982-94 [10919287] Development. 2002 Mar;129(6):1377-86 [11880347] Endocrinology. 2002 Jun;143(6):2357-65 [12021201] Proc Natl Acad Sci U S A. 1975 Sep;72(9):3585-9 [1059147] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/onc.2010.439 ER - TY - JOUR T1 - Chimeric ferritin nanocages for multiple function loading and multimodal imaging. AN - 851227629; 21210706 AB - Nanomaterials provide large surface areas, relativeto their volumes, on which to load functions. One challenge, however, has been to achieve precise control in loading multiple functionalities. Traditional bioconjugation techniques, which randomly target the surface functional groups of nanomaterials, have been found increasingly inadequate for such control, which is a drawback that may substantially slow down or prohibit the translational efforts. In the current study, we evaluated ferritin nanocages as candidate nanoplatforms for multifunctional loading. Ferritin nanocages can be either genetically or chemically modified to impart functionalities to their surfaces, and metal cations can be encapsulated in their interiors by association with metal binding sites. Moreover, different types of ferritin nanocages can be disassembled under acidic condition and reassembled at pH of 7.4, providing a facile way to achieve function hybridization. We were able to use combinations of these unique properties to produce a number of multifunctional ferritin nanostructures with precise control of their composition. We then studied these nanoparticles, both in vitro and in vivo, to evaluate their potential suitability as multimodality imaging probes. A good tumor targeting profile was observed, which was attributable to both the enhanced permeability and retention (EPR) effect and biovector mediated targeting. This, in combination with the generalizability of the function loading techniques, promises ferritin particles as a powerful nanoplatfom in the era of nanomedicine. JF - Nano letters AU - Lin, Xin AU - Xie, Jin AU - Niu, Gang AU - Zhang, Fan AU - Gao, Haokao AU - Yang, Min AU - Quan, Qimeng AU - Aronova, Maria A AU - Zhang, Guofeng AU - Lee, Seulki AU - Leapman, Richard AU - Chen, Xiaoyuan AD - Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892, USA. Y1 - 2011/02/09/ PY - 2011 DA - 2011 Feb 09 SP - 814 EP - 819 VL - 11 IS - 2 KW - Nanocapsules KW - 0 KW - Ferritins KW - 9007-73-2 KW - Index Medicus KW - Animals KW - Humans KW - Nanocapsules -- ultrastructure KW - Ferritins -- chemistry KW - Molecular Imaging -- methods KW - Neoplasms, Experimental -- pathology KW - Subtraction Technique KW - Nanocapsules -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/851227629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nano+letters&rft.atitle=Chimeric+ferritin+nanocages+for+multiple+function+loading+and+multimodal+imaging.&rft.au=Lin%2C+Xin%3BXie%2C+Jin%3BNiu%2C+Gang%3BZhang%2C+Fan%3BGao%2C+Haokao%3BYang%2C+Min%3BQuan%2C+Qimeng%3BAronova%2C+Maria+A%3BZhang%2C+Guofeng%3BLee%2C+Seulki%3BLeapman%2C+Richard%3BChen%2C+Xiaoyuan&rft.aulast=Lin&rft.aufirst=Xin&rft.date=2011-02-09&rft.volume=11&rft.issue=2&rft.spage=814&rft.isbn=&rft.btitle=&rft.title=Nano+letters&rft.issn=1530-6992&rft_id=info:doi/10.1021%2Fnl104141g LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-19 N1 - Date created - 2011-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Am Chem Soc. 2008 Dec 10;130(49):16527-9 [19554690] J Nucl Med. 2008 Jun;49 Suppl 2:113S-28S [18523069] Small. 2009 Aug 3;5(15):1706-21 [19572330] Biomaterials. 2009 Dec;30(36):6912-9 [19773081] Nano Lett. 2010 Jan;10(1):219-23 [20017497] Biomaterials. 2010 Apr;31(11):3016-22 [20092887] Eur J Nucl Med Mol Imaging. 2010 Mar;37(3):645-51 [20187296] Chem Rev. 2010 May 12;110(5):3087-111 [20225899] Chem Rev. 2010 May 12;110(5):3146-95 [20225900] J Am Chem Soc. 2008 Jun 18;130(24):7542-3 [18500805] Inorg Chem. 2000 Apr 17;39(8):1828-30 [12526579] Biophys J. 2003 Apr;84(4):2256-63 [12668434] J Nucl Med. 2004 Jan;45 Suppl 1:72S-81S [14736838] Eur J Nucl Med Mol Imaging. 2004 Jun;31 Suppl 1:S135-42 [15133636] Biochem J. 1989 Dec 1;264(2):381-8 [2690826] J Biol Chem. 1992 Jul 15;267(20):14077-83 [1629207] J Mol Biol. 1997 May 2;268(2):424-48 [9159481] Langmuir. 2004 Nov 9;20(23):10283-7 [15518526] Annu Rev Biomed Eng. 2006;8:35-62 [16834551] Cancer Res. 2006 Sep 15;66(18):9196-201 [16982763] J Med Chem. 2006 Oct 5;49(20):6087-93 [17004722] J Am Chem Soc. 2006 Dec 27;128(51):16626-33 [17177411] J Nucl Med. 2007 Jul;48(7):1162-71 [17574975] Curr Pharm Des. 2008;14(28):2943-73 [18991712] J Am Chem Soc. 2009 Apr 15;131(14):5094-100 [19317403] Curr Med Chem. 2009;16(10):1278-94 [19355885] Mol Imaging. 2009 Mar-Apr;8(2):87-100 [19397854] J Nucl Med. 2007 Nov;48(11):1862-70 [17942800] J Nucl Med. 2008 Mar;49(3):453-61 [18287274] J Biomed Mater Res A. 2008 Jun 1;85(3):797-807 [17896765] J Nucl Med. 2009 Jul;50(7):1168-77 [19525469] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/nl104141g ER - TY - CPAPER T1 - A Sequential Program and Arm Strategy for Fc Fragments with a C-Terminal Selenocysteine T2 - 2011 Keystone Symposia on Antibodies as Drugs AN - 1312981091; 6064878 JF - 2011 Keystone Symposia on Antibodies as Drugs AU - Rader, Christoph Y1 - 2011/02/06/ PY - 2011 DA - 2011 Feb 06 KW - Selenocysteine KW - Fc UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312981091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Antibodies+as+Drugs&rft.atitle=A+Sequential+Program+and+Arm+Strategy+for+Fc+Fragments+with+a+C-Terminal+Selenocysteine&rft.au=Rader%2C+Christoph&rft.aulast=Rader&rft.aufirst=Christoph&rft.date=2011-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Antibodies+as+Drugs&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1094&CFID=386688&CFTOKEN=63836434 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Identification of Broadly Neutralizing Human MAbs to HIV-1: Applications to Vaccine Design, Passive Protection and HIV Therapy T2 - 2011 Keystone Symposia on Antibodies as Drugs AN - 1312929919; 6064883 JF - 2011 Keystone Symposia on Antibodies as Drugs AU - Nabel, Gary Y1 - 2011/02/06/ PY - 2011 DA - 2011 Feb 06 KW - Human immunodeficiency virus KW - vaccines KW - Monoclonal antibodies KW - Vaccines KW - Therapy KW - Disease control KW - Human immunodeficiency virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312929919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Antibodies+as+Drugs&rft.atitle=Identification+of+Broadly+Neutralizing+Human+MAbs+to+HIV-1%3A+Applications+to+Vaccine+Design%2C+Passive+Protection+and+HIV+Therapy&rft.au=Nabel%2C+Gary&rft.aulast=Nabel&rft.aufirst=Gary&rft.date=2011-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Antibodies+as+Drugs&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1094&CFID=386688&CFTOKEN=63836434 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - A Signature of Maternal Anti-Fetal Rejection in Spontaneous Preterm Birth: Chronic Chorioamnionitis, Anti-Human Leukocyte Antigen Antibodies, and C4d AN - 907155743; 14389663 AB - Chronic chorioamnionitis is found in more than one-third of spontaneous preterm births. Chronic chorioamnionitis and villitis of unknown etiology represent maternal anti-fetal cellular rejection. Antibody-mediated rejection is another type of transplantation rejection. We investigated whether there was evidence for antibody-mediated rejection against the fetus in spontaneous preterm birth. This cross-sectional study included women with (1) normal pregnancy and term delivery (n=140) and (2) spontaneous preterm delivery (n=140). We analyzed maternal and fetal sera for panel-reactive anti-HLA class I and class II antibodies, and determined C4d deposition on umbilical vein endothelium by immunohistochemistry. Maternal anti-HLA class I seropositivity in spontaneous preterm births was higher than in normal term births (48.6% vs. 32.1%, p=0.005). Chronic chorioamnionitis was associated with a higher maternal anti-HLA class I seropositivity (p&0.01), significant in preterm and term birth. Villitis of unknown etiology was associated with increased maternal and fetal anti-HLA class I and II seropositivity (p&0.05, for each). Fetal anti-HLA seropositivity was closely related to maternal anti-HLA seropositivity in both groups (p&0.01, for each). C4d deposition on umbilical vein endothelium was more frequent in preterm labor than term labor (77.1% vs. 11.4%, p&0.001). Logistic regression analysis revealed that chronic chorioamnionitis (OR=6.10, 95% CI 1.29-28.83), maternal anti-HLA class I seropositivity (OR=5.90, 95% CI 1.60-21.83), and C4d deposition on umbilical vein endothelium (OR=36.19, 95% CI 11.42-114.66) were associated with preterm labor and delivery. A major subset of spontaneous preterm births has a signature of maternal anti-fetal cellular and antibody-mediated rejections with links to fetal graft-versus-host disease and alloimmune reactions. JF - PLoS ONE AU - Lee, JoonHo AU - Romero, Roberto AU - Xu, Yi AU - Kim, Jung-Sun AU - Topping, Vanessa AU - Yoo, Wonsuk AU - Kusanovic, Juan Pedro AU - Chaiworapongsa, Tinnakorn AU - Hassan, Sonia S AU - Yoon, Bo Hyun AU - Kim, Chong Jai AD - Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, and Detroit, Michigan, United States of America Y1 - 2011/02/04/ PY - 2011 DA - 2011 Feb 04 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 6 IS - 2 KW - Toxicology Abstracts; Immunology Abstracts KW - Antibodies KW - Birth KW - Chorioamnionitis KW - Endothelium KW - Etiology KW - Fetuses KW - Graft rejection KW - Graft-versus-host reaction KW - Histocompatibility antigen HLA KW - Immunohistochemistry KW - Leukocytes KW - Pregnancy KW - Regression analysis KW - umbilical vein KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907155743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=A+Signature+of+Maternal+Anti-Fetal+Rejection+in+Spontaneous+Preterm+Birth%3A+Chronic+Chorioamnionitis%2C+Anti-Human+Leukocyte+Antigen+Antibodies%2C+and+C4d&rft.au=Lee%2C+JoonHo%3BRomero%2C+Roberto%3BXu%2C+Yi%3BKim%2C+Jung-Sun%3BTopping%2C+Vanessa%3BYoo%2C+Wonsuk%3BKusanovic%2C+Juan+Pedro%3BChaiworapongsa%2C+Tinnakorn%3BHassan%2C+Sonia+S%3BYoon%2C+Bo+Hyun%3BKim%2C+Chong+Jai&rft.aulast=Lee&rft.aufirst=JoonHo&rft.date=2011-02-04&rft.volume=6&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0016806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-11-20 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Etiology; Graft rejection; Leukocytes; Graft-versus-host reaction; umbilical vein; Fetuses; Pregnancy; Birth; Antibodies; Endothelium; Regression analysis; Chorioamnionitis; Immunohistochemistry DO - http://dx.doi.org/10.1371/journal.pone.0016806 ER - TY - JOUR T1 - Pregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration. AN - 848688340; 21127053 AB - Pregnane X receptor (PXR) was originally characterized as a transcription factor that induces hepatic drug metabolism by activating cytochrome P450 genes. Here we have now demonstrated a novel function of PXR, that of eliciting p38 mitogen-activated protein kinase (MAPK) phosphorylation for cell migration. Upon xenobiotic activation of ectopic human PXR, human hepatocellular carcinoma HepG2 cells were found to exhibit increased phosphorylation of p38 MAPK and to subsequently change morphology and migrate. p38 MAPK was responsible for the regulation of these morphological changes and cell migration because the p38 MAPK inhibitor SB239063 repressed both. Prior to this phosphorylation, PXR directly activated the early response GADD45β gene by binding to a distal direct repeat 4 site of the GADD45β promoter. Ectopic expression of GADD45β increased p38 MAPK phosphorylation, whereas siRNA knockdown of GADD45β decreased the PXR-induced p38 MAPK phosphorylation, confirming that GADD45β can regulate PXR-induced p38 MAPK phosphorylation in HepG2 cells. These results indicate that PXR activates the GADD45β gene, increasing p38 MAPK phosphorylation, and leading HepG2 cells to change morphology and migrate. The GADD45β gene is a direct target for PXR, eliciting cell signals to regulate various cellular functions. JF - The Journal of biological chemistry AU - Kodama, Susumu AU - Negishi, Masahiko AD - Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2011/02/04/ PY - 2011 DA - 2011 Feb 04 SP - 3570 EP - 3578 VL - 286 IS - 5 KW - Antigens, Differentiation KW - 0 KW - GADD45B protein, human KW - Receptors, Steroid KW - pregnane X receptor KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Phosphorylation KW - Hep G2 Cells KW - Humans KW - Cell Line, Tumor KW - Cell Shape KW - Cell Movement KW - Receptors, Steroid -- physiology KW - Antigens, Differentiation -- genetics KW - p38 Mitogen-Activated Protein Kinases -- metabolism KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/848688340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Pregnane+X+receptor+PXR+activates+the+GADD45beta+gene%2C+eliciting+the+p38+MAPK+signal+and+cell+migration.&rft.au=Kodama%2C+Susumu%3BNegishi%2C+Masahiko&rft.aulast=Kodama&rft.aufirst=Susumu&rft.date=2011-02-04&rft.volume=286&rft.issue=5&rft.spage=3570&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M110.179812 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-21 N1 - Date created - 2011-01-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 1998 Jan 9;92(1):73-82 [9489701] Oncogene. 1996 Jun 20;12(12):2579-94 [8700517] Digestion. 2005;71(2):78-91 [15775675] Biochim Biophys Acta. 2005 Aug 15;1745(1):48-58 [16085054] Hepatology. 2005 Nov;42(5):1118-26 [16231353] EMBO J. 2006 Feb 22;25(4):713-26 [16456544] J Biol Chem. 2006 Jun 30;281(26):17882-9 [16608838] J Clin Invest. 2006 Aug;116(8):2280-2289 [16841097] Mol Cell Biol. 2007 Apr;27(7):2765-76 [17242196] J Biol Chem. 2007 Mar 30;282(13):9768-76 [17267396] Biochem J. 2007 Nov 1;407(3):373-81 [17635106] Drug Metab Pharmacokinet. 2008;23(1):8-13 [18305370] Mol Endocrinol. 2008 Apr;22(4):868-80 [18096695] Hepatology. 2008 Apr;47(4):1277-87 [18167061] J Clin Invest. 2008 May;118(5):1911-23 [18382767] Drug Metab Dispos. 2008 Jul;36(7):1189-93 [18362160] Curr Drug Metab. 2008 Sep;9(7):614-21 [18781913] Nucl Recept Signal. 2009;7:e001 [19240808] Trends Endocrinol Metab. 2009 Aug;20(6):273-9 [19595610] J Gastroenterol Hepatol. 2010 Feb;25(2):420-6 [19793165] PLoS One. 2010;5(4):e10121 [20404936] Hepatology. 2010 May;51(5):1614-23 [20209605] Cell Signal. 1999 Dec;11(12):885-90 [10659996] Biochem Biophys Res Commun. 2000 May 27;272(1):193-8 [10872826] Drug Metab Dispos. 2001 Nov;29(11):1467-72 [11602523] Mol Cell Biol. 2002 Jul;22(13):4544-55 [12052864] J Cell Sci. 2002 Aug 1;115(Pt 15):3193-206 [12118074] J Cell Physiol. 2002 Sep;192(3):327-38 [12124778] Mol Pharmacol. 2002 Sep;62(3):638-46 [12181440] EMBO J. 2002 Dec 2;21(23):6473-82 [12456654] Mol Cell Biol. 2003 Jan;23(1):216-28 [12482975] J Biol Chem. 2003 Oct 31;278(44):43001-7 [12933797] Drug Metab Dispos. 2004 Jan;32(1):149-54 [14709632] Mol Cell Biol. 2004 Sep;24(18):7931-40 [15340055] J Cell Sci. 2004 Sep 15;117(Pt 20):4619-28 [15371522] Mol Cell Biol. 1998 Oct;18(10):5652-8 [9742082] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M110.179812 ER - TY - JOUR T1 - NRF2, cancer and calorie restriction. AN - 849433530; 21057541 AB - The transcription factor NF-E2-related factor (NRF2) is a key regulator of several enzymatic pathways, including cytoprotective enzymes in highly metabolic organs. In this review, we summarize the ongoing research related to NRF2 activity in cancer development, focusing on in vivo studies using NRF2 knockout (KO) mice, which have helped in defining the crucial role of NRF2 in chemoprevention. The lower cancer protection observed in NRF2 KO mice under calorie restriction (CR) suggests that most of the beneficial effects of CR on the carcinogenesis process are likely mediated by NRF2. We propose that future interventions in cancer treatment would be carried out through the activation of NRF2 in somatic cells, which will lead to a delay or prevention of the onset of some forms of human cancers, and subsequently an extension of health- and lifespan. JF - Oncogene AU - Martín-Montalvo, A AU - Villalba, J M AU - Navas, P AU - de Cabo, R AD - Aging, Metabolism and Nutrition Unit, Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. Y1 - 2011/02/03/ PY - 2011 DA - 2011 Feb 03 SP - 505 EP - 520 VL - 30 IS - 5 KW - NF-E2-Related Factor 2 KW - 0 KW - Index Medicus KW - Animals KW - Cell Nucleus -- metabolism KW - Humans KW - Mice KW - Models, Biological KW - Mice, Knockout KW - NF-E2-Related Factor 2 -- genetics KW - Caloric Restriction KW - Neoplasms -- genetics KW - Neoplasms -- metabolism KW - NF-E2-Related Factor 2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849433530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=NRF2%2C+cancer+and+calorie+restriction.&rft.au=Mart%C3%ADn-Montalvo%2C+A%3BVillalba%2C+J+M%3BNavas%2C+P%3Bde+Cabo%2C+R&rft.aulast=Mart%C3%ADn-Montalvo&rft.aufirst=A&rft.date=2011-02-03&rft.volume=30&rft.issue=5&rft.spage=505&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2010.492 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-04-22 N1 - Date created - 2011-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/onc.2010.492 ER - TY - JOUR T1 - Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies AN - 904468696; 14341212 AB - BACKGROUND: Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors. METHODS: We pooled tumor marker and epidemiological risk factor data from 35 568 invasive breast cancer case patients from 34 studies participating in the Breast Cancer Association Consortium. Logistic regression models were used in case-case analyses to estimate associations between epidemiological risk factors and tumor subtypes, and case-control analyses to estimate associations between epidemiological risk factors and the risk of developing specific tumor subtypes in 12 population-based studies. All statistical tests were two-sided. RESULTS: In case-case analyses, of the epidemiological risk factors examined, early age at menarche ( less than or equal to 12 years) was less frequent in case patients with PR- than PR+ tumors (P = .001). Nulliparity (P = 3 x 10-6) and increasing age at first birth (P = 2 x 10-9) were less frequent in ER- than in ER+ tumors. Obesity (body mass index [BMI] greater than or equal to 30 kg/m2) in younger women ( less than or equal to 50 years) was more frequent in ER-/PR- than in ER+/PR+ tumors (P = 1 x 10-7), whereas obesity in older women (>50 years) was less frequent in PR- than in PR+ tumors (P = 6 x 10-4). The triple-negative (ER-/PR-/HER2-) or core basal phenotype (CBP; triple-negative and cytokeratins [CK]5/6+ and/or epidermal growth factor receptor [EGFR]+) accounted for much of the heterogeneity in parity-related variables and BMI in younger women. Case-control analyses showed that nulliparity, increasing age at first birth, and obesity in younger women showed the expected associations with the risk of ER+ or PR+ tumors but not triple-negative (nulliparity vs parity, odds ratio [OR] = 0.94, 95% confidence interval [CI] = 0.75 to 1.19, P = .61; 5-year increase in age at first full-term birth, OR = 0.95, 95% CI = 0.86 to 1.05, P = .34; obesity in younger women, OR = 1.36, 95% CI = 0.95 to 1.94, P = .09) or CBP tumors. CONCLUSIONS: This study shows that reproductive factors and BMI are most clearly associated with hormone receptor-positive tumors and suggest that triple-negative or CBP tumors may have distinct etiology. JF - Journal of the National Cancer Institute AU - Yang, Xiaohong R AU - Chang-Claude, Jenny AU - Goode, Ellen L AU - Couch, Fergus J AU - Nevanlinna, Heli AU - Milne, Roger L AU - Gaudet, Mia AU - Schmidt, Marjanka K AU - Broeks, Annegien AU - Cox, Angela AU - Fasching, Peter A AU - Hein, Rebecca AU - Spurdle, Amanda B AU - Blows, Fiona AU - Driver, Kristy AU - Flesch-Janys, Dieter AU - Heinz, Judith AU - Sinn, Peter AU - Vrieling, Alina AU - Heikkinen, Tuomas AU - Aittomaeki, Kristiina AU - Heikkilae, Paeivi AU - Blomqvist, Carl AU - Lissowska, Jolanta AU - Peplonska, Beata AU - Chanock, Stephen AU - Figueroa, Jonine AU - Brinton, Louise AU - Hall, Per AU - Czene, Kamila AU - Humphreys, Keith AU - Darabi, Hatef AU - Liu, Jianjun AU - Van 't Veer, Laura J AU - van Leeuwen, Flora E AU - Andrulis, Irene L AU - Glendon, Gord AU - Knight, Julia A AU - Mulligan, Anna Marie AU - O'Malley, Frances P AU - Weerasooriya, Nayana AU - John, Esther M AU - Beckmann, Matthias W AU - Hartmann, Arndt AU - Weihbrecht, Sebastian B AU - Wachter, David L AU - Jud, Sebastian M AU - Loehberg, Christian R AU - Baglietto, Laura AU - English, Dallas R AU - Giles, Graham G AU - McLean, Catriona A AU - Severi, Gianluca AU - Lambrechts, Diether AU - Vandorpe, Thijs AU - Weltens, Caroline AU - Paridaens, Robert AU - Smeets, Ann AU - Neven, Patrick AU - Wildiers, Hans AU - Wang, Xianshu AU - Olson, Janet E AU - Cafourek, Victoria AU - Fredericksen, Zachary AU - Kosel, Matthew AU - Vachon, Celine AU - Cramp, Helen E AU - Connley, Daniel AU - Cross, Simon S AU - Balasubramanian, Sabapathy P AU - Reed, Malcolm WR AU - Doerk, Thilo AU - Bremer, Michael AU - Meyer, Andreas AU - Karstens, Johann H AU - Ay, Aysun AU - Park-Simon, Tjoung-Won AU - Hillemanns, Peter AU - Arias Perez, Jose Ignacio AU - Rodriguez, Primitiva Menendez AU - Zamora, Pilar AU - Benitez, Javier AU - Ko, Yon-Dschun AU - Fischer, Hans-Peter AU - Hamann, Ute AU - Pesch, Beate AU - Bruening, Thomas AU - Justenhoven, Christina AU - Brauch, Hiltrud AU - Eccles, Diana M AU - Tapper, William J AU - Gerty, Sue M AU - Sawyer, Elinor J AU - Tomlinson, Ian P AU - Jones, Angela AU - Kerin, Michael AU - Miller, Nicola AU - McInerney, Niall AU - Anton-Culver, Hoda AU - Ziogas, Argyrios AU - Shen, Chen-Yang AU - Hsiung, Chia-Ni AU - Wu, Pei-Ei AU - Yang, Show-Lin AU - Yu, Jyh-Cherng AU - Chen, Shou-Tung AU - Hsu, Giu-Cheng AU - Haiman, Christopher A AU - Henderson, Brian E AU - Le Marchand, Loic AU - Kolonel, Laurence N AU - Lindblom, Annika AU - Margolin, Sara AU - Jakubowska, Anna AU - Lubinski, Jan AU - Huzarski, Tomasz AU - Byrski, Tomasz AU - Gorski, Bohdan AU - Gronwald, Jacek AU - Hooning, Maartje J AU - Hollestelle, Antoinette AU - van den Ouweland, Ans MW AU - Jager, Agnes AU - Kriege, Mieke AU - Tilanus-Linthorst, Madeleine MA AU - Collee, Margriet AU - Wang-Gohrke, Shan AU - Pylkaes, Katri AU - Jukkola-Vuorinen, Arja AU - Mononen, Kari AU - Grip, Mervi AU - Hirvikoski, Pasi AU - Winqvist, Robert AU - Mannermaa, Arto AU - Kosma, Veli-Matti AU - Kauppinen, Jaana AU - Kataja, Vesa AU - Auvinen, Paeivi AU - Soini, Ylermi AU - Sironen, Reijo AU - Bojesen, Stig E AU - Dynnes Oersted, David AU - Kaur-Knudsen, Diljit AU - Flyger, Henrik AU - Nordestgaard, Boerge G AU - Holland, Helene AU - Chenevix-Trench, Georgia AU - Manoukian, Siranoush AU - Barile, Monica AU - Radice, Paolo AU - Hankinson, Susan E AU - Hunter, David J AU - Tamimi, Rulla AU - Sangrajrang, Suleeporn AU - Brennan, Paul AU - McKay, James AU - Odefrey, Fabrice AU - Gaborieau, Valerie AU - Devilee, Peter AU - Huijts, PEA AU - Tollenaar, RAEM AU - Seynaeve, C AU - Dite, Gillian S AU - Apicella, Carmel AU - Hopper, John L AU - Hammet, Fleur AU - Tsimiklis, Helen AU - Smith, Letitia D AU - Southey, Melissa C AU - Humphreys, Manjeet K AU - Easton, Douglas AU - Pharoah, Paul AU - Sherman, Mark E AU - Garcia-Closas, Montserrat AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Sciences, Rockville, MD (XRY, SC, JF, LBr, MES, MG-C) Y1 - 2011/02/02/ PY - 2011 DA - 2011 Feb 02 SP - 250 EP - 263 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 103 IS - 3 SN - 0027-8874, 0027-8874 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - parity KW - obesity KW - tumors KW - Cancer KW - Risk factors KW - Breast cancer KW - growth factors KW - estrogens KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904468696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Associations+of+Breast+Cancer+Risk+Factors+With+Tumor+Subtypes%3A+A+Pooled+Analysis+From+the+Breast+Cancer+Association+Consortium+Studies&rft.au=Yang%2C+Xiaohong+R%3BChang-Claude%2C+Jenny%3BGoode%2C+Ellen+L%3BCouch%2C+Fergus+J%3BNevanlinna%2C+Heli%3BMilne%2C+Roger+L%3BGaudet%2C+Mia%3BSchmidt%2C+Marjanka+K%3BBroeks%2C+Annegien%3BCox%2C+Angela%3BFasching%2C+Peter+A%3BHein%2C+Rebecca%3BSpurdle%2C+Amanda+B%3BBlows%2C+Fiona%3BDriver%2C+Kristy%3BFlesch-Janys%2C+Dieter%3BHeinz%2C+Judith%3BSinn%2C+Peter%3BVrieling%2C+Alina%3BHeikkinen%2C+Tuomas%3BAittomaeki%2C+Kristiina%3BHeikkilae%2C+Paeivi%3BBlomqvist%2C+Carl%3BLissowska%2C+Jolanta%3BPeplonska%2C+Beata%3BChanock%2C+Stephen%3BFigueroa%2C+Jonine%3BBrinton%2C+Louise%3BHall%2C+Per%3BCzene%2C+Kamila%3BHumphreys%2C+Keith%3BDarabi%2C+Hatef%3BLiu%2C+Jianjun%3BVan+%27t+Veer%2C+Laura+J%3Bvan+Leeuwen%2C+Flora+E%3BAndrulis%2C+Irene+L%3BGlendon%2C+Gord%3BKnight%2C+Julia+A%3BMulligan%2C+Anna+Marie%3BO%27Malley%2C+Frances+P%3BWeerasooriya%2C+Nayana%3BJohn%2C+Esther+M%3BBeckmann%2C+Matthias+W%3BHartmann%2C+Arndt%3BWeihbrecht%2C+Sebastian+B%3BWachter%2C+David+L%3BJud%2C+Sebastian+M%3BLoehberg%2C+Christian+R%3BBaglietto%2C+Laura%3BEnglish%2C+Dallas+R%3BGiles%2C+Graham+G%3BMcLean%2C+Catriona+A%3BSeveri%2C+Gianluca%3BLambrechts%2C+Diether%3BVandorpe%2C+Thijs%3BWeltens%2C+Caroline%3BParidaens%2C+Robert%3BSmeets%2C+Ann%3BNeven%2C+Patrick%3BWildiers%2C+Hans%3BWang%2C+Xianshu%3BOlson%2C+Janet+E%3BCafourek%2C+Victoria%3BFredericksen%2C+Zachary%3BKosel%2C+Matthew%3BVachon%2C+Celine%3BCramp%2C+Helen+E%3BConnley%2C+Daniel%3BCross%2C+Simon+S%3BBalasubramanian%2C+Sabapathy+P%3BReed%2C+Malcolm+WR%3BDoerk%2C+Thilo%3BBremer%2C+Michael%3BMeyer%2C+Andreas%3BKarstens%2C+Johann+H%3BAy%2C+Aysun%3BPark-Simon%2C+Tjoung-Won%3BHillemanns%2C+Peter%3BArias+Perez%2C+Jose+Ignacio%3BRodriguez%2C+Primitiva+Menendez%3BZamora%2C+Pilar%3BBenitez%2C+Javier%3BKo%2C+Yon-Dschun%3BFischer%2C+Hans-Peter%3BHamann%2C+Ute%3BPesch%2C+Beate%3BBruening%2C+Thomas%3BJustenhoven%2C+Christina%3BBrauch%2C+Hiltrud%3BEccles%2C+Diana+M%3BTapper%2C+William+J%3BGerty%2C+Sue+M%3BSawyer%2C+Elinor+J%3BTomlinson%2C+Ian+P%3BJones%2C+Angela%3BKerin%2C+Michael%3BMiller%2C+Nicola%3BMcInerney%2C+Niall%3BAnton-Culver%2C+Hoda%3BZiogas%2C+Argyrios%3BShen%2C+Chen-Yang%3BHsiung%2C+Chia-Ni%3BWu%2C+Pei-Ei%3BYang%2C+Show-Lin%3BYu%2C+Jyh-Cherng%3BChen%2C+Shou-Tung%3BHsu%2C+Giu-Cheng%3BHaiman%2C+Christopher+A%3BHenderson%2C+Brian+E%3BLe+Marchand%2C+Loic%3BKolonel%2C+Laurence+N%3BLindblom%2C+Annika%3BMargolin%2C+Sara%3BJakubowska%2C+Anna%3BLubinski%2C+Jan%3BHuzarski%2C+Tomasz%3BByrski%2C+Tomasz%3BGorski%2C+Bohdan%3BGronwald%2C+Jacek%3BHooning%2C+Maartje+J%3BHollestelle%2C+Antoinette%3Bvan+den+Ouweland%2C+Ans+MW%3BJager%2C+Agnes%3BKriege%2C+Mieke%3BTilanus-Linthorst%2C+Madeleine+MA%3BCollee%2C+Margriet%3BWang-Gohrke%2C+Shan%3BPylkaes%2C+Katri%3BJukkola-Vuorinen%2C+Arja%3BMononen%2C+Kari%3BGrip%2C+Mervi%3BHirvikoski%2C+Pasi%3BWinqvist%2C+Robert%3BMannermaa%2C+Arto%3BKosma%2C+Veli-Matti%3BKauppinen%2C+Jaana%3BKataja%2C+Vesa%3BAuvinen%2C+Paeivi%3BSoini%2C+Ylermi%3BSironen%2C+Reijo%3BBojesen%2C+Stig+E%3BDynnes+Oersted%2C+David%3BKaur-Knudsen%2C+Diljit%3BFlyger%2C+Henrik%3BNordestgaard%2C+Boerge+G%3BHolland%2C+Helene%3BChenevix-Trench%2C+Georgia%3BManoukian%2C+Siranoush%3BBarile%2C+Monica%3BRadice%2C+Paolo%3BHankinson%2C+Susan+E%3BHunter%2C+David+J%3BTamimi%2C+Rulla%3BSangrajrang%2C+Suleeporn%3BBrennan%2C+Paul%3BMcKay%2C+James%3BOdefrey%2C+Fabrice%3BGaborieau%2C+Valerie%3BDevilee%2C+Peter%3BHuijts%2C+PEA%3BTollenaar%2C+RAEM%3BSeynaeve%2C+C%3BDite%2C+Gillian+S%3BApicella%2C+Carmel%3BHopper%2C+John+L%3BHammet%2C+Fleur%3BTsimiklis%2C+Helen%3BSmith%2C+Letitia+D%3BSouthey%2C+Melissa+C%3BHumphreys%2C+Manjeet+K%3BEaston%2C+Douglas%3BPharoah%2C+Paul%3BSherman%2C+Mark+E%3BGarcia-Closas%2C+Montserrat&rft.aulast=Yang&rft.aufirst=Xiaohong&rft.date=2011-02-02&rft.volume=103&rft.issue=3&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-04-06 N1 - SubjectsTermNotLitGenreText - parity; Age; Risk factors; obesity; Breast cancer; tumors; growth factors; Cancer; estrogens ER - TY - JOUR T1 - Measuring Goodness of Story Narratives AN - 993927242; 201203791 AB - Purpose: The purpose of this article was to evaluate a new measure of story narrative performance: story completeness. It was hypothesized that by combining organizational (story grammar) and completeness measures, story "goodness" could be quantified. Method: Discourse samples from 46 typically developing adults were compared with those from 24 adults with acquired brain injuries. Story retellings were elicited and analyzed for episode structure (story grammar). Each story was also evaluated for the presence of 5 key components, yielding the story completeness score. Story goodness was quantified by combining the story grammar and completeness measures using a 2-coordinate grid system. A multivariate analysis of variance was performed as well as correlational analyses between the story grammar and story completeness scores. Results: There were significant group differences on both story grammar and story completeness. Moderate correlations were noted between the 2 measures, suggesting that the indices were not entirely measuring the same abilities. Plotting the 2 sets of scores into quadrants discriminated the comparison group and the group with brain injury into 4 distinct categories of story "goodness." Conclusion: The combination of measures provided a more accurate depiction of discourse performance than either measure alone. Results suggest the measure is sensitive, is reliable, and has potential utility for investigating discourse deficits in clinical populations. Adapted from the source document JF - Journal of Speech, Language, and Hearing Research AU - Le, Karen AU - Mozeiko, Jennifer AU - Grafman, Jordan AD - National Institutes of Health, Bethesda, MD grafmanj@ninds.nih.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 118 EP - 126 VL - 54 IS - 1 SN - 1092-4388, 1092-4388 KW - Language Impairment (42700) KW - Discourse Analysis (19200) KW - Narratives (56170) KW - Brain Damage (09400) KW - Story Grammar (84350) KW - Adults (00600) KW - Discourse Strategies (19255) KW - article KW - 6410: language-pathological and normal; language and speech pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/993927242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.atitle=Measuring+Goodness+of+Story+Narratives&rft.au=Le%2C+Karen%3BMozeiko%2C+Jennifer%3BGrafman%2C+Jordan&rft.aulast=Le&rft.aufirst=Karen&rft.date=2011-02-01&rft.volume=54&rft.issue=1&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.issn=10924388&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2012-04-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Story Grammar (84350); Discourse Analysis (19200); Discourse Strategies (19255); Adults (00600); Narratives (56170); Brain Damage (09400); Language Impairment (42700) ER - TY - JOUR T1 - Advanced theory of driven birdcage resonator with losses for biomedical magnetic resonance imaging and spectroscopy AN - 954633745; 14331246 AB - A complete time-dependent physics theory of symmetric unperturbed driven hybrid birdcage resonator was developed for general application. In particular, the theory can be applied for radiofrequency (RF) coil engineering, computer simulations of coil-sample interaction, etc. Explicit time dependence is evaluated for different forms of driving voltage. The major steps of the solution development are shown and appropriate explanations are given. Green's functions and spectral density formula were developed for any form of periodic driving voltage. The concept of distributed power losses based on transmission line theory is developed for evaluation of local losses of a coil. Three major types of power losses are estimated as equivalent series resistances in the circuit of the birdcage resonator. Values of generated resistances in legs and end-rings are estimated. An application of the theory is shown for many practical cases. Experimental curve of B sub(1) field polarization dependence is measured for eight-sections birdcage coil. It was shown that the steady-state driven resonance frequencies do not depend on damping factor unlike the free oscillation (transient) frequencies. An equivalent active resistance is generated due to interaction of RF electromagnetic field with a sample. Resistance of the conductor (enhanced by skin effect), Eddy currents and dielectric losses are the major types of losses which contribute to the values of generated resistances. A biomedical sample for magnetic resonance imaging and spectroscopy is the source of the both Eddy current and dielectric losses of a coil. As demonstrated by the theory, Eddy current loss is the major effect of coil shielding. JF - Magnetic Resonance Imaging AU - Novikov, Alexander AD - National Institute of Mental Health, National Institutes of Health, Bethesda MD 20892, USA, anovikov41@yahoo.com Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 260 EP - 271 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 29 IS - 2 SN - 0730-725X, 0730-725X KW - Biotechnology and Bioengineering Abstracts KW - Leg KW - Skin KW - Mathematical models KW - Oscillations KW - Hybrids KW - Magnetic resonance imaging KW - Circuits KW - Conductors KW - Spectroscopy KW - Polarization KW - Electromagnetic fields KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954633745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=Advanced+theory+of+driven+birdcage+resonator+with+losses+for+biomedical+magnetic+resonance+imaging+and+spectroscopy&rft.au=Novikov%2C+Alexander&rft.aulast=Novikov&rft.aufirst=Alexander&rft.date=2011-02-01&rft.volume=29&rft.issue=2&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2010.08.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Leg; Mathematical models; Skin; Oscillations; Hybrids; Magnetic resonance imaging; Circuits; Conductors; Polarization; Spectroscopy; Electromagnetic fields DO - http://dx.doi.org/10.1016/j.mri.2010.08.001 ER - TY - JOUR T1 - Comparison of elliptical training, stationary cycling, treadmill walking and overground walking. Electromyographic patterns AN - 954632867; 14414861 AB - The most common functional motor goal of lower extremity rehabilitation is to improve walking ability. For reasons of feasibility, safety or intensity, devices are frequently used to facilitate or augment gait training. The objective of this study was to compare the muscle activity patterns of the rectus femoris and semitendinosus muscles during four conditions: overground walking, treadmill walking, stationary cycling, and elliptical training. ten healthy adults (six male, four female; mean age 22.7 +/- 2.9 years, range 20-29) participated and surface electromyographic data were recorded. Linear envelope curves were generated and time normalized from 0 to 100% cycle. The mean plus three standard deviations from a static trial was used as the threshold for muscle activity. Repeated measures analysis of variance procedures were used to detect differences between conditions. Elliptical training demonstrated greater rectus femoris activity and greater rectus femoris/semitendinosus coactivation than all other conditions. Consistent with previous work, treadmill walking demonstrated greater rectus femoris activity than overground walking. Minimal differences in semitendinosus activation were observed between conditions, limited to lower peak activity during cycling compared to treadmill walking. These results provide normative values for rectus femoris and semitendinosus activation for different locomotor training methods and may assist in selecting the most appropriate training device for specific patients. Clinicians and researchers should also consider the kinematic and kinetic differences between tasks, which cannot necessarily be inferred from muscle activation patterns. JF - Gait & Posture AU - Prosser, Laura A AU - Stanley, Christopher J AU - Norman, Tracy L AU - Park, Hyung S AU - Damiano, Diane L AD - Functional and Applied Biomechanics Section, Rehabilitation Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD 20892, United States, damianod@cc.nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 244 EP - 250 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 33 IS - 2 SN - 0966-6362, 0966-6362 KW - Physical Education Index KW - Bicycling KW - Kinematics KW - Rehabilitation KW - Analysis KW - Kinetics KW - Walking KW - Legs KW - Muscles (activity) KW - Treadmill ergometry KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954632867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gait+%26+Posture&rft.atitle=Comparison+of+elliptical+training%2C+stationary+cycling%2C+treadmill+walking+and+overground+walking.+Electromyographic+patterns&rft.au=Prosser%2C+Laura+A%3BStanley%2C+Christopher+J%3BNorman%2C+Tracy+L%3BPark%2C+Hyung+S%3BDamiano%2C+Diane+L&rft.aulast=Prosser&rft.aufirst=Laura&rft.date=2011-02-01&rft.volume=33&rft.issue=2&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Gait+%26+Posture&rft.issn=09666362&rft_id=info:doi/10.1016%2Fj.gaitpost.2010.11.013 LA - English DB - Physical Education Index N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Bicycling; Kinematics; Rehabilitation; Kinetics; Analysis; Walking; Legs; Muscles (activity); Treadmill ergometry DO - http://dx.doi.org/10.1016/j.gaitpost.2010.11.013 ER - TY - JOUR T1 - Gait patterns during different walking conditions in older adults with and without knee osteoarthritis - Results from the Baltimore Longitudinal Study of Aging AN - 954620159; 14414854 AB - Biomechanical analysis of lower extremity activities while walking at different speeds and in challenging conditions may help to identify specific gait patterns associated with knee osteoarthritis (knee-OA). We hypothesized that individuals with asymptomatic knee-OA have lower ankle activity, while individuals with symptomatic knee-OA have similar or higher ankle activity compared to individuals without knee-OA, and that such differences are enhanced during challenging gait tasks. We tested this hypothesis by examining gait characteristics in multiple gait tasks using data from 153 Baltimore Longitudinal Study of Aging (BLSA) participants (112 without knee-OA, 41 with knee-OA; 53-87 years, 52% women). All participants who could walk unassisted were evaluated in the BLSA gait lab while walking at self-selected speed (usual-walking), at maximum speed (fast-walking) and again at self-selected speed after 30-min of walking activities (usual-walking-after-30 min). Knee range of motion was lower for knee-OA participants in the fast-walking and usual-walking-after-30 min tasks (p < 0.030). Ankle range of motion for symptomatic knee-OA was greater compared to asymptomatic knee-OA for all walking tasks (p < 0.050). Symptomatic knee-OA had greater generative MWE of the ankle compared to asymptomatic knee-OA (p = 0.034), while keeping similar absorptive MWE of the knee when compared to no-OA controls (p = 0.151). Symptomatic knee-OA individuals seem to adapt an ankle kinematic gait pattern aimed at avoiding knee pain, by enhancing forward propulsion so to minimize knee joint load. Whether these conditions represent subsequent steps in the causal pathway from knee-OA to changes in gait is still not clear. JF - Gait & Posture AU - Ko, Seung-Uk AU - Ling, Shari M AU - Schreiber, Catherine AU - Nesbitt, Mark AU - Ferrucci, Luigi AD - National Institute on Aging (NIA), Clinical Research Branch, Baltimore, MD, USA, kos2mail.nih.govseunguk.ko@gmail.com Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 205 EP - 210 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 33 IS - 2 SN - 0966-6362, 0966-6362 KW - Calcium & Calcified Tissue Abstracts; Physical Education Index KW - Longitudinal studies KW - Kinematics KW - Data processing KW - Osteoarthritis KW - Flexibility KW - Aging KW - Knees KW - Ankles KW - Walking KW - Pain KW - Knee KW - Joints KW - Speed KW - Arthritis KW - Ankle KW - gait KW - Posture KW - Gait KW - Activities KW - T 2030:Cartilage and Cartilage Diseases KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954620159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gait+%26+Posture&rft.atitle=Gait+patterns+during+different+walking+conditions+in+older+adults+with+and+without+knee+osteoarthritis+-+Results+from+the+Baltimore+Longitudinal+Study+of+Aging&rft.au=Ko%2C+Seung-Uk%3BLing%2C+Shari+M%3BSchreiber%2C+Catherine%3BNesbitt%2C+Mark%3BFerrucci%2C+Luigi&rft.aulast=Ko&rft.aufirst=Seung-Uk&rft.date=2011-02-01&rft.volume=33&rft.issue=2&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Gait+%26+Posture&rft.issn=09666362&rft_id=info:doi/10.1016%2Fj.gaitpost.2010.11.006 LA - English DB - Physical Education Index N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-04-23 N1 - SubjectsTermNotLitGenreText - Longitudinal studies; Speed; Flexibility; Arthritis; Ankles; Knees; Walking; Activities; Gait; Kinematics; Data processing; Osteoarthritis; Aging; Pain; Ankle; gait; Posture; Knee; Joints DO - http://dx.doi.org/10.1016/j.gaitpost.2010.11.006 ER - TY - JOUR T1 - Molecular imaging in cancer treatment AN - 954617636; 14211299 AB - The success of cancer therapy can be difficult to predict, as its efficacy is often predicated upon characteristics of the cancer, treatment, and individual that are not fully understood or are difficult to ascertain. Monitoring the response of disease to treatment is therefore essential and has traditionally been characterized by changes in tumor volume. However, in many instances, this singular measure is insufficient for predicting treatment effects on patient survival. Molecular imaging allows repeated in vivo measurement of many critical molecular features of neoplasm, such as metabolism, proliferation, angiogenesis, hypoxia, and apoptosis, which can be employed for monitoring therapeutic response. In this review, we examine the current methods for evaluating response to treatment and provide an overview of emerging PET molecular imaging methods that will help guide future cancer therapies. JF - European Journal of Nuclear Medicine and Molecular Imaging AU - Michalski, Mark H AU - Chen, Xiaoyuan AD - Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), 31 Center Drive, Suite 1C14, Bethesda, MD, 20892-2281, USA, shawn.chen@nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 358 EP - 377 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 38 IS - 2 SN - 1619-7070, 1619-7070 KW - Biotechnology and Bioengineering Abstracts KW - Apoptosis KW - Reviews KW - Hypoxia KW - Angiogenesis KW - Nuclear medicine KW - Survival KW - Tumors KW - Cancer KW - Metabolism KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954617636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.atitle=Molecular+imaging+in+cancer+treatment&rft.au=Michalski%2C+Mark+H%3BChen%2C+Xiaoyuan&rft.aulast=Michalski&rft.aufirst=Mark&rft.date=2011-02-01&rft.volume=38&rft.issue=2&rft.spage=358&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.issn=16197070&rft_id=info:doi/10.1007%2Fs00259-010-1569-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Apoptosis; Hypoxia; Reviews; Angiogenesis; Survival; Nuclear medicine; Tumors; Metabolism; Cancer DO - http://dx.doi.org/10.1007/s00259-010-1569-z ER - TY - JOUR T1 - Alcohol consumption and risk of renal cell cancer: the NIH-AARP diet and health study AN - 954597557; 14310118 AB - Background:The effect of moderate to heavy drinking (>15g per day) on renal cell cancer (RCC) risk is unclear. Method:The relationship between alcohol consumption and RCC was examined in the NIH-AARP Diet and Health Study (n=492187, 1814 cases). Results:Compared with >0 to <5g per day of alcohol consumption, the multivariate relative risk (95% confidence intervals) for 15 to <30 and greater than or equal to 30g per day was, 0.75 (0.63-0.90) and 0.71 (0.59-0.85), respectively, in men and 0.67 (0.42-1.07) and 0.43 (0.22-0.84), respectively, in women. Conclusion:Alcohol consumption was inversely associated with RCC in a dose-response manner. The inverse association may be extended to greater than or equal to 30g per day of alcohol intake. JF - British Journal of Cancer AU - Lew, J Q AU - Chow, W-H AU - Hollenbeck, A R AU - Schatzkin, A AU - Park, Y AD - 1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Bethesda, MD, USA [2] St. Louis Children's Hospital, Washington University Medical Center, St. Louis, MO, USA Y1 - 2011/02/01/ PY - 2011 DA - 2011 Feb 01 SP - 537 EP - 541 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 104 IS - 3 SN - 0007-0920, 0007-0920 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Alcohol KW - Cancer KW - Diets KW - Dose-response effects KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954597557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Alcohol+consumption+and+risk+of+renal+cell+cancer%3A+the+NIH-AARP+diet+and+health+study&rft.au=Lew%2C+J+Q%3BChow%2C+W-H%3BHollenbeck%2C+A+R%3BSchatzkin%2C+A%3BPark%2C+Y&rft.aulast=Lew&rft.aufirst=J&rft.date=2011-02-01&rft.volume=104&rft.issue=3&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6606089 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-08-24 N1 - SubjectsTermNotLitGenreText - Diets; Alcohol; Dose-response effects; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6606089 ER - TY - JOUR T1 - Automated radiochemical synthesis of [ super(18)F]FBEM: A thiol reactive synthon for radiofluorination of peptides and proteins AN - 918044929; 14181431 AB - The automated radiochemical synthesis of N-[2-(4-[ super(18)F]fluorobenzamido)ethyl]maleimide ([ super(18)F]FBEM, IUPAC name: N-maleoylethyl-4-[ super(18)F]fluorobenzamide), a prosthetic group for radiolabeling the free sulfhydryl groups of peptides and proteins, is herein described. 4-[ super(18)F]fluorobenzoic acid was first prepared by nucleophilic displacement of a trimethylammonium moiety on a pentamethylbenzyl benzoate ester with [ super(18)F]fluoride. In the second step the ester was cleaved under acidic conditions. Finally, 4-[ super(18)F]fluorobenzoic acid was coupled to N-(2-aminoethyl)maleimide using diethylcyanophosphate and diisopropylethyl amine. Following high-performance liquid chromatography (HPLC) purification, [ super(18)F]FBEM was obtained in 17.3+/-7.1% yield (not decay corrected) in approximately 95 min. Isolation from the HPLC eluate and preparation for subsequent use, which was conducted manually, required an additional 10-15 min. The measured specific activity for three batches was 181.3, 251.6, and 351.5 GBq/ mu mol at the end of bombardment (EOB). JF - Applied Radiation and Isotopes AU - Kiesewetter, Dale O AU - Jacobson, Orit AU - Lang, Lixin AU - Chen, Xiaoyuan AD - Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Building 10, Room 1C401, MSC 1180, Bethesda, MD 20892, USA, dk7k@nih.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 410 EP - 414 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 69 IS - 2 SN - 0969-8043, 0969-8043 KW - Environment Abstracts KW - PET KW - Fluorine-18 KW - Thiol reactive synthon KW - [18F]FBEM KW - Isotopes KW - Liquid chromatography KW - Proteins KW - Decay KW - Esters KW - Amines KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918044929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Radiation+and+Isotopes&rft.atitle=Automated+radiochemical+synthesis+of+%5B+super%2818%29F%5DFBEM%3A+A+thiol+reactive+synthon+for+radiofluorination+of+peptides+and+proteins&rft.au=Kiesewetter%2C+Dale+O%3BJacobson%2C+Orit%3BLang%2C+Lixin%3BChen%2C+Xiaoyuan&rft.aulast=Kiesewetter&rft.aufirst=Dale&rft.date=2011-02-01&rft.volume=69&rft.issue=2&rft.spage=410&rft.isbn=&rft.btitle=&rft.title=Applied+Radiation+and+Isotopes&rft.issn=09698043&rft_id=info:doi/10.1016%2Fj.apradiso.2010.09.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2016-06-22 N1 - SubjectsTermNotLitGenreText - Isotopes; Liquid chromatography; Proteins; Decay; Amines; Esters DO - http://dx.doi.org/10.1016/j.apradiso.2010.09.023 ER - TY - JOUR T1 - Imaging upregulated brain arachidonic acid metabolism in HIV-1 transgenic rats AN - 918044819; 14335349 AB - Human immunodeficiency virus (HIV)-associated infection involves the entry of virus-bearing monocytes into the brain, followed by microglial activation, neuroinflammation, and upregulated arachidonic acid (AA) metabolism. The HIV-1 transgenic (Tg) rat, a noninfectious HIV-1 model, shows neurologic and behavioral abnormalities after 5 months of age. We hypothesized that brain AA metabolism would be elevated in older HIV-1 Tg rats in vivo. Arachidonic acid incorporation from the plasma into the brain of unanesthetized 7-to-9-month-old rats was imaged using quantitative autoradiography, after [1- super(14)C]AA infusion. Brain phospholipase (PLA sub(2)) activities and eicosanoid concentrations were measured, and enzymes were localized by immunostaining. AA incorporation coefficients k super(*) and rates J sub(in), measures of AA metabolism, were significantly higher in 69 of 81 brain regions in HIV-1 Tg than in control rats, as were activities of cytosolic (c)PLA sub(2)-IV, secretory (s)PLA sub(2), and calcium independent (i)PLA sub(2)-VI, as well as prostaglandin E sub(2) and leukotriene B sub(4) concentrations. Immunostaining of somatosensory cortex showed elevated cPLA sub(2)-IV, sPLA sub(2)-IIA, and cyclooxygenase-2 in neurons. Brain AA incorporation and other markers of AA metabolism are upregulated in HIV-1 Tg rats, in which neurologic changes and neuroinflammation have been reported. Positron emission tomography with [1- super(11)C]AA could be used to test whether brain AA metabolism is upregulated in HIV-1-infected patients, in relation to cognitive and behavioral disturbances. JF - Journal of Cerebral Blood Flow and Metabolism AU - Basselin, Mireille AU - Ramadan, Epolia AU - Igarashi, Miki AU - Chang, Lisa AU - Chen, Mei AU - Kraft, Andrew D AU - Harry, G Jean AU - Rapoport, Stanley I AD - Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 486 EP - 493 PB - Nature Publishing Group VL - 31 IS - 2 SN - 0271-678X, 0271-678X KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Age KW - Animal models KW - Arachidonic acid KW - Autoradiography KW - Brain KW - Calcium KW - Cell activation KW - Cerebral blood flow KW - Cognitive ability KW - Cortex (somatosensory) KW - Cyclooxygenase-2 KW - Enzymes KW - Infection KW - Inflammation KW - Leukotriene B4 KW - Metabolism KW - Monocytes KW - Neuroimaging KW - Neurons KW - Phospholipase A2 KW - Positron emission tomography KW - Prostaglandin E2 KW - eicosanoids KW - phospholipase KW - Human immunodeficiency virus 1 KW - V 22360:AIDS and HIV KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918044819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cerebral+Blood+Flow+and+Metabolism&rft.atitle=Imaging+upregulated+brain+arachidonic+acid+metabolism+in+HIV-1+transgenic+rats&rft.au=Basselin%2C+Mireille%3BRamadan%2C+Epolia%3BIgarashi%2C+Miki%3BChang%2C+Lisa%3BChen%2C+Mei%3BKraft%2C+Andrew+D%3BHarry%2C+G+Jean%3BRapoport%2C+Stanley+I&rft.aulast=Basselin&rft.aufirst=Mireille&rft.date=2011-02-01&rft.volume=31&rft.issue=2&rft.spage=486&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cerebral+Blood+Flow+and+Metabolism&rft.issn=0271678X&rft_id=info:doi/10.1038%2Fjcbfm.2010.111 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Cyclooxygenase-2; Age; Neuroimaging; Calcium; eicosanoids; Phospholipase A2; Animal models; Brain; Arachidonic acid; Enzymes; phospholipase; Prostaglandin E2; Infection; Autoradiography; Inflammation; Cell activation; Leukotriene B4; Cognitive ability; Neurons; Positron emission tomography; Monocytes; Cortex (somatosensory); Metabolism; Cerebral blood flow; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1038/jcbfm.2010.111 ER - TY - JOUR T1 - Haplotype-Based Study of the Association of Alcohol-Metabolizing Genes With Alcohol Dependence in Four Independent Populations AN - 918043613; 14301788 AB - Background: Ethanol is metabolized by 2 rate-limiting reactions: alcohol dehydrogenases (ADH) convert ethanol to acetaldehyde that is subsequently metabolized to acetate by aldehyde dehydrogenases (ALDH). Approximately 50% of East Asians have genetic variants that significantly impair this pathway and influence alcohol dependence (AD) vulnerability. We investigated whether variation in alcohol metabolism genes might alter the AD risk in four non-East Asian populations by performing systematic haplotype association analyses to maximize the chances of capturing functional variation. Methods: Haplotype-tagging SNPs were genotyped using the Illumina GoldenGate platform. Genotypes were available for 40 SNPs across the ADH genes cluster and 24 SNPs across the two ALDH genes in four diverse samples that included cases (lifetime AD) and controls (no Axis 1 disorders). The case control sample sizes were the following: Finnish Caucasians: 232, 194; African Americans: 267, 422; Plains American Indians: 226, 110; and Southwestern American (SW) Indians: 317, 72. Results: In all four populations, as well as HapMap populations, 5 haplotype blocks were identified across the ADH gene cluster: (i) ADH5-ADH4; (ii) ADH6-ADH1A-ADH1B; (iii) ADH1C; (iv) intergenic; (v) ADH7. The ALDH1A1 gene was defined by 4 blocks and ALDH2 by 1 block. No haplotype or SNP association results were significant after correction for multiple comparisons; however, several results, particularly for ALDH1A1 and ADH4, replicated earlier findings. There was an ALDH1A1 block 1 and 2 (extending from intron 5 to the 3' UTR) yin yang haplotype (haplotypes that have opposite allelic configuration) association with AD in the Finns driven by SNPs rs3764435 and rs2303317, respectively, and an ALDH1A1 block 3 (including the promoter region) yin yang haplotype association in SW Indians driven by 5 SNPs, all in allelic identity. The ADH4 SNP rs3762894 was associated with AD in Plains Indians. Conclusions: The systematic evaluation of alcohol-metabolizing genes in four non-East Asian populations has shown only modest associations with AD, largely for ALDH1A1 and ADH4. A concentration of signals for AD with ALDH1A1 yin yang haplotypes in several populations warrants further study. JF - Alcoholism: Clinical and Experimental Research AU - Liu, Jixia AU - Zhou, Zhifeng AU - Hodgkinson, Colin A AU - Yuan, Qiaoping AU - Shen, Pei-Hong AU - Mulligan, Connie J AU - Wang, Alex AU - Gray, Rebecca R AU - Roy, Alec AU - Virkkunen, Matti AU - Goldman, David AU - Enoch, Mary-Anne AD - From the Laboratory of Neurogenetics (JL, ZZ, CAH, QY, P-HS, AW, DG, M-AE), National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland; Department of Anthropology (CJM, AW, RRG), University of Florida, Gainesville, Florida; Mental Health and Behavioral Science, Department of Veterans Affairs (AR), New Jersey Health Care System, East Orange, New Jersey; Institute of Clinical Medicine, Department of Psychiatry (MV), University of Helsinki, Finland; Kellokoski Hospital (MV), Kellokoski, Finland. Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 304 EP - 316 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 35 IS - 2 SN - 0145-6008, 0145-6008 KW - Genetics Abstracts; Toxicology Abstracts KW - ADH4 protein KW - Acetaldehyde KW - Acetic acid KW - Alcohol dehydrogenase KW - Alcoholism KW - Aldehyde dehydrogenase KW - Association analysis KW - Drug abuse KW - Drug dependence KW - Ethanol KW - Genotypes KW - Haplotypes KW - Introns KW - Metabolism KW - Population studies KW - Promoters KW - Single-nucleotide polymorphism KW - X 24380:Social Poisons & Drug Abuse KW - G 07880:Human Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918043613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%3A+Clinical+and+Experimental+Research&rft.atitle=Haplotype-Based+Study+of+the+Association+of+Alcohol-Metabolizing+Genes+With+Alcohol+Dependence+in+Four+Independent+Populations&rft.au=Liu%2C+Jixia%3BZhou%2C+Zhifeng%3BHodgkinson%2C+Colin+A%3BYuan%2C+Qiaoping%3BShen%2C+Pei-Hong%3BMulligan%2C+Connie+J%3BWang%2C+Alex%3BGray%2C+Rebecca+R%3BRoy%2C+Alec%3BVirkkunen%2C+Matti%3BGoldman%2C+David%3BEnoch%2C+Mary-Anne&rft.aulast=Liu&rft.aufirst=Jixia&rft.date=2011-02-01&rft.volume=35&rft.issue=2&rft.spage=304&rft.isbn=&rft.btitle=&rft.title=Alcoholism%3A+Clinical+and+Experimental+Research&rft.issn=01456008&rft_id=info:doi/10.1111%2Fj.1530-0277.2010.01346.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Document feature - figure 3 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Association analysis; Acetaldehyde; Alcohol dehydrogenase; Population studies; Genotypes; Drug abuse; Acetic acid; Drug dependence; Promoters; ADH4 protein; Haplotypes; Single-nucleotide polymorphism; Alcoholism; Introns; Aldehyde dehydrogenase; Metabolism; Ethanol DO - http://dx.doi.org/10.1111/j.1530-0277.2010.01346.x ER - TY - JOUR T1 - PG01037, a novel dopamine D3 receptor antagonist, inhibits the effects of methamphetamine in rats AN - 907152983; 14306983 AB - Our previous studies have shown that the selective dopamine D sub(3) receptor antagonists SB-277011A or NGB 2904 significantly attenuate cocaine self-administration under a progressive-ratio reinforcement schedule and cocaine-, methamphetamine- or nicotine-enhanced brain stimulation reward. However, the poor bioavailability of SB-277011A has limited its potential use in humans. In the present study, we investigated the effects of the novel D sub(3) receptor antagonist PG01037 on methamphetamine self-administration, methamphetamine-associated cue-induced reinstatement of drug seeking and methamphetamine-enhanced brain stimulation reward. Rats were allowed to intravenously self-administer methamphetamine under fixed-ratio 2 and progressive-ratio reinforcement conditions, and then the effects of PG01037 on methamphetamine self-administration and cue-induced reinstatement were assessed. Additional groups of rats were trained for intracranial electrical brain stimulation reward and the effects of PG01037 and methamphetamine on brain stimulation reward were assessed. Acute intraperitoneal administration of PG01037 (3, 10, 30 mg/kg) failed to alter methamphetamine or sucrose self-administration under fixed-ratio 2 reinforcement, but significantly lowered the break-point levels for methamphetamine or sucrose self-administration under progressive-ratio reinforcement. In addition, PG01037 significantly inhibited methamphetamine-associated cue-triggered reinstatement of drug-seeking behavior and methamphetamine-enhanced brain stimulation reward. These data suggest that the novel D sub(3) antagonist PG01037 significantly attenuates the rewarding effects as assessed by progressive-ratio self-administration and brain stimulation reward, and inhibits methamphetamine-associated cue-induced reinstatement of drug-seeking behavior These findings support the potential use of PG01037 or other selective D sub(3) antagonists in the treatment of methamphetamine addiction. JF - Journal of Psychopharmacology AU - Higley, Amanda E AU - Spiller, Krista AU - Grundt, Peter AU - Hauck Newman, Amy AU - Kiefer, Stephen W AU - Xi, Zheng-Xiong AU - Gardner, Eliot L AD - Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD, 21224 USA, Department of Psychology, Kansas State University, Manhattan KS, 66506, USA, ahigley@scripps.edu Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 263 EP - 273 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 25 IS - 2 SN - 0269-8811, 0269-8811 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Addiction KW - Bioavailability KW - Brain KW - Data processing KW - Dopamine D3 receptors KW - Drug abuse KW - Drug addiction KW - Drug self-administration KW - Methamphetamine KW - Reinforcement KW - Reinforcement schedules KW - Reinstatement KW - Sucrose KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907152983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychopharmacology&rft.atitle=PG01037%2C+a+novel+dopamine+D3+receptor+antagonist%2C+inhibits+the+effects+of+methamphetamine+in+rats&rft.au=Higley%2C+Amanda+E%3BSpiller%2C+Krista%3BGrundt%2C+Peter%3BHauck+Newman%2C+Amy%3BKiefer%2C+Stephen+W%3BXi%2C+Zheng-Xiong%3BGardner%2C+Eliot+L&rft.aulast=Higley&rft.aufirst=Amanda&rft.date=2011-02-01&rft.volume=25&rft.issue=2&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychopharmacology&rft.issn=02698811&rft_id=info:doi/10.1177%2F0269881109358201 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Number of references - 76 N1 - Last updated - 2012-11-20 N1 - SubjectsTermNotLitGenreText - Data processing; Dopamine D3 receptors; Brain; Drug abuse; Reinstatement; Reinforcement schedules; Bioavailability; Methamphetamine; Sucrose; Reinforcement; Addiction; Drug addiction; Drug self-administration DO - http://dx.doi.org/10.1177/0269881109358201 ER - TY - JOUR T1 - A Novel Role for IFN-Stimulated Gene Factor 3II in IFN- gamma Signaling and Induction of Antiviral Activity in Human Cells AN - 907151120; 14266434 AB - Type I (e.g., IFN- alpha , IFN- beta ) and type II IFNs (IFN- gamma ) have antiviral, antiproliferative, and immunomodulatory properties. Both types of IFN signal through the Jak/STAT pathway to elicit antiviral activity, yet IFN- gamma is thought to do so only through STAT1 homodimers, whereas type I IFNs activate both STAT1- and STAT2-containing complexes such as IFN-stimulated gene factor 3. In this study, we show that IFN-stimulated gene factor 3 containing unphosphorylated STAT2 (ISGF3II) also plays a role in IFN- gamma -mediated antiviral activity in humans. Using phosphorylated STAT1 as a marker for IFN signaling, Western blot analysis of IFN- alpha 2a-treated human A549 cells revealed that phospho-STAT1 (Y701) levels peaked at 1 h, decreased by 6 h, and remained at low levels for up to 48 h. Cells treated with IFN- gamma showed a biphasic phospho-STAT1 response with an early peak at 1-2 h and a second peak at 15-24 h. Gene expression microarray following IFN- gamma treatment for 24 h indicated an induction of antiviral genes that are induced by IFN-stimulated gene factor 3 and associated with a type I IFN response. Induction of these genes by autocrine type I and type III IFN signaling was ruled out using neutralizing Abs to these IFNs in biological assays and by quantitative RT-PCR. Despite the absence of autocrine IFNs, IFN- gamma treatment induced formation of ISGF3II. This novel transcription factor complex binds to IFN-stimulated response element promoter sequences, as shown by chromatin immunoprecipitation analysis of the protein kinase R promoter. STAT2 and IFN regulatory factor 9 knockdown in A549 cells reversed IFN- gamma -mediated IFN-stimulated response element induction and antiviral activity, implicating ISGF3II formation as a significant component of the cellular response and biological activity of IFN- gamma . JF - Journal of Immunology AU - Morrow, Angel N AU - Schmeisser, Hana AU - Tsuno, Takaya AU - Zoon, Kathryn C AD - Cytokine Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2011/02/01/ PY - 2011 DA - 2011 Feb 01 SP - 1685 EP - 1693 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA VL - 186 IS - 3 SN - 0022-1767, 0022-1767 KW - Virology & AIDS Abstracts; Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - beta -Interferon KW - Western blotting KW - gamma -Interferon KW - Chromatin KW - Regulatory sequences KW - Immunoprecipitation KW - Antiviral activity KW - DNA microarrays KW - Immunomodulation KW - Gene expression KW - Promoters KW - Interferon KW - protein kinase R KW - Autocrine signalling KW - Stat1 protein KW - Transcription factors KW - alpha -Interferon KW - Polymerase chain reaction KW - Signal transduction KW - G 07720:Immunogenetics KW - A 01340:Antibiotics & Antimicrobials KW - V 22350:Immunology KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907151120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=A+Novel+Role+for+IFN-Stimulated+Gene+Factor+3II+in+IFN-+gamma+Signaling+and+Induction+of+Antiviral+Activity+in+Human+Cells&rft.au=Morrow%2C+Angel+N%3BSchmeisser%2C+Hana%3BTsuno%2C+Takaya%3BZoon%2C+Kathryn+C&rft.aulast=Morrow&rft.aufirst=Angel&rft.date=2011-02-01&rft.volume=186&rft.issue=3&rft.spage=1685&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - beta -Interferon; gamma -Interferon; Western blotting; Chromatin; Regulatory sequences; Immunoprecipitation; Antiviral activity; Immunomodulation; DNA microarrays; Gene expression; protein kinase R; Interferon; Promoters; Autocrine signalling; Stat1 protein; Transcription factors; alpha -Interferon; Polymerase chain reaction; Signal transduction ER - TY - JOUR T1 - CD4 T Cells Promote Rather than Control Tuberculosis in the Absence of PD-1-Mediated Inhibition AN - 907149472; 14266444 AB - Although CD4 T cells are required for host resistance to Mycobacterium tuberculosis, they may also contribute to pathology. In this study, we examine the role of the inhibitory receptor PD-1 and its ligand PD-L1 during M. tuberculosis infection. After aerosol exposure, PD-1 knockout (KO) mice develop high numbers of M. tuberculosis-specific CD4 T cells but display markedly increased susceptibility to infection. Importantly, we show that CD4 T cells themselves drive the increased bacterial loads and pathology seen in infected PD-1 KO mice, and PD-1 deficiency in CD4 T cells is sufficient to trigger early mortality. PD-L1 KO mice also display enhanced albeit less severe susceptibility, indicating that T cells are regulated by multiple PD ligands during M. tuberculosis infection. M. tuberculosis-specific CD8 T cell responses were normal in PD-1 KO mice, and CD8 T cells only had a minor contribution to the exacerbated disease in the M. tuberculosis-infected PD-1 KO and PD-L1 KO mice. Thus, in the absence of the PD-1 pathway, M. tuberculosis benefits from CD4 T cell responses, and host resistance requires inhibition by PD-1 to prevent T cell-driven exacerbation of the infection. JF - Journal of Immunology AU - Barber, Daniel L AU - Mayer-Barber, Katrin D AU - Feng, Carl G AU - Sharpe, Arlene H AU - Sher, Alan AD - Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2011/02/01/ PY - 2011 DA - 2011 Feb 01 SP - 1598 EP - 1607 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA VL - 186 IS - 3 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - PD-1 protein KW - Mortality KW - CD4 antigen KW - Aerosols KW - Lymphocytes T KW - PD-L1 protein KW - Tuberculosis KW - CD8 antigen KW - Infection KW - Mycobacterium tuberculosis KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907149472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=CD4+T+Cells+Promote+Rather+than+Control+Tuberculosis+in+the+Absence+of+PD-1-Mediated+Inhibition&rft.au=Barber%2C+Daniel+L%3BMayer-Barber%2C+Katrin+D%3BFeng%2C+Carl+G%3BSharpe%2C+Arlene+H%3BSher%2C+Alan&rft.aulast=Barber&rft.aufirst=Daniel&rft.date=2011-02-01&rft.volume=186&rft.issue=3&rft.spage=1598&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Mortality; PD-1 protein; Aerosols; CD4 antigen; PD-L1 protein; Lymphocytes T; Tuberculosis; CD8 antigen; Infection; Mycobacterium tuberculosis ER - TY - JOUR T1 - In utero exposure to maternal smoking and women's risk of fetal loss in the Norwegian Mother and Child Cohort (MoBa) AN - 904466854; 14267853 AB - BACKGROUND: Whether in utero exposure to tobacco smoke increases a woman's risk of fetal loss later in life is unknown, though data on childhood exposure suggest an association may exist. This study evaluated the association between in utero exposure to tobacco smoke and fetal loss in the Norwegian Mother and Child Cohort Study (MoBa), which enrolled similar to 40% of the pregnant women in Norway from 1999 to 2008. METHODS: Information on exposure to tobacco smoke in utero, the woman's own smoking behavior during pregnancy and other factors was obtained by a questionnaire completed at similar to 17 weeks of gestation. Subsequent late miscarriage (fetal death <20 weeks) and stillbirth (fetal death greater than or equal to 20 weeks) were ascertained from the Norwegian Medical Birth Registry. This analysis included 76 357 pregnancies (MoBa data set version 4.301) delivered by the end of 2008; 59 late miscarriages and 270 stillbirths occurred. Cox proportional hazards models were fit for each outcome and for all fetal deaths combined. RESULTS: The adjusted hazard ratio (HR) of late miscarriage was 1.23 [95% confidence interval (CI), 0.72-2.12] in women with exposure to maternal tobacco smoke in utero when compared with non-exposed women. The corresponding adjusted HR for stillbirths was 1.11 (95% CI, 0.85-1.44) and for all fetal deaths combined, it was 1.12 (95% CI, 0.89-1.43). CONCLUSIONS: The relatively wide CI around the HR for miscarriage reflected the limited power to detect an association, due to enrollment around 17 weeks of gestation. However, for in utero exposure to tobacco smoke and risk of stillbirth later in life, where the study power was adequate, our data provided little support for an association. JF - Human Reproduction AU - Cupul-Uicab, LA AU - Baird, D D AU - Skjaerven, R AU - Saha-Chaudhuri, P AU - Haug, K AU - Longnecker, M P AD - Epidemiology Branch, National Institute of Environmental Health Sciences NIH/DHHS/USA, MD A3-05, 111 TW Alexander Dr, Research Triangle Park, NC 27709, USA Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 458 EP - 465 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 26 IS - 2 SN - 0268-1161, 0268-1161 KW - Risk Abstracts KW - Smoke KW - Mortality KW - Smoking KW - Prenatal experience KW - Abortion KW - Tobacco KW - Reproduction KW - Females KW - Norway KW - Pregnancy KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904466854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Reproduction&rft.atitle=In+utero+exposure+to+maternal+smoking+and+women%27s+risk+of+fetal+loss+in+the+Norwegian+Mother+and+Child+Cohort+%28MoBa%29&rft.au=Cupul-Uicab%2C+LA%3BBaird%2C+D+D%3BSkjaerven%2C+R%3BSaha-Chaudhuri%2C+P%3BHaug%2C+K%3BLongnecker%2C+M+P&rft.aulast=Cupul-Uicab&rft.aufirst=LA&rft.date=2011-02-01&rft.volume=26&rft.issue=2&rft.spage=458&rft.isbn=&rft.btitle=&rft.title=Human+Reproduction&rft.issn=02681161&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Smoke; Smoking; Mortality; Prenatal experience; Abortion; Tobacco; Reproduction; Females; Pregnancy; Norway ER - TY - JOUR T1 - Cholesterol, endocrine and metabolic disturbances in sporadic anovulatory women with regular menstruation AN - 904466416; 14267858 AB - BACKGROUND: Sporadic anovulation among regularly menstruating women is not well understood. It is hypothesized that cholesterol abnormalities may lead to hormone imbalances and incident anovulation. The objective was to evaluate the association between lipoprotein cholesterol levels and endocrine and metabolic disturbances and incident anovulation among ovulatory and anovulatory women reporting regular menstruation. METHODS: The BioCycle Study was a prospective cohort study conducted at the University at Buffalo from September 2005 to 2007, which followed 259 self-reported regularly menstruating women aged 18-44 years, for one or two complete menstrual cycles. Sporadic anovulation was assessed across two menstrual cycles. RESULTS: Mean total and low-density lipoprotein cholesterol and triglycerides levels across the menstrual cycles were higher during anovulatory cycles (mean difference: 4.6 (P = 0.01), 3.0 (P = 0.06) and 6.4 (P = 0.0002) mg/dl, respectively, adjusted for age and BMI). When multiple total cholesterol (TC) measures prior to expected ovulation were considered, we observed a slight increased risk of anovulation associated with increased levels of TC (odds ratio per 5 mg/dl increase, 1.07; 95% confidence interval, 0.99, 1.16). Sporadic anovulation was associated with an increased LH:FSH ratio (P = 0.002), current acne (P = 0.02) and decreased sex hormone-binding globulin levels (P = 0.005). CONCLUSIONS: These results do not support a strong association between lipoprotein cholesterol levels and sporadic anovulation. However, sporadic anovulation among regularly menstruating women is associated with endocrine disturbances which are typically observed in women with polycystic ovary syndrome. JF - Human Reproduction AU - Mumford, Sunni L AU - Schisterman, Enrique F AU - Siega-Riz, Anna Maria AU - Gaskins, Audrey J AU - Steiner, Anne Z AU - Daniels, Julie L AU - Olshan, Andrew F AU - Hediger, Mary L AU - Hovey, Kathleen AU - Wactawski-Wende, Jean AU - Trevisan, Maurizio AU - Bloom, Michael S AD - Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, 6100 Executive Boulevard 7B03, Rockville, MD 20852, USA Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 423 EP - 430 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 26 IS - 2 SN - 0268-1161, 0268-1161 KW - Risk Abstracts KW - Age KW - cholesterol KW - Hormones KW - body mass KW - Reproduction KW - Females KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904466416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Reproduction&rft.atitle=Cholesterol%2C+endocrine+and+metabolic+disturbances+in+sporadic+anovulatory+women+with+regular+menstruation&rft.au=Mumford%2C+Sunni+L%3BSchisterman%2C+Enrique+F%3BSiega-Riz%2C+Anna+Maria%3BGaskins%2C+Audrey+J%3BSteiner%2C+Anne+Z%3BDaniels%2C+Julie+L%3BOlshan%2C+Andrew+F%3BHediger%2C+Mary+L%3BHovey%2C+Kathleen%3BWactawski-Wende%2C+Jean%3BTrevisan%2C+Maurizio%3BBloom%2C+Michael+S&rft.aulast=Mumford&rft.aufirst=Sunni&rft.date=2011-02-01&rft.volume=26&rft.issue=2&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Human+Reproduction&rft.issn=02681161&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Age; body mass; Reproduction; Females; Hormones; cholesterol ER - TY - JOUR T1 - Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional G x G and G x E differences in health and disease AN - 902342606; 14767515 AB - Recent major findings from studies of SLC6A4 and its corresponding protein, the serotonin (5-HT) transporter (SERT) in humans, rodents and non-human primates indicate that combinations of SLC6A4 non-coding 5', 3' UTRs and intronic regions plus coding variants acting together can change 5HT transport as much as 40-fold in vitro. In vivo, SLC6A4 variants in humans and other species lead to marked physiological changes, despite mitigating neurodevelopmental adaptations in 5-HT receptors plus compensatory alterations in 5-HT synthesis and metabolism. Polymorphisms in SLC6A4 are associated with differences in emotional, endocrine, and personality characteristics as well as many diseases. This gene, in combinations with gene x gene (G x G) and gene x environment (G x E) interactions nonetheless remains incompletely understood, with some association findings remaining controversial. Considering its primary importance in the regulation and function of the entire serotonergic system (as evidenced by the consequences of SERT-mediated reuptake inhibition by SRIs like fluoxetine in humans and of genetically engineered changes in mice and rats), it seems likely that SLC6A4 and SERT will remain areas of high interest in our field's attempts to better understand and treat 5-HT-related disorders. JF - Current Opinion in Pharmacology AU - Murphy, Dennis L AU - Moya, Pablo R AD - Laboratory of Clinical Science, NIMH Intramural Research Program, Bethesda, MD 20892, USA, dm30h@nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 3 EP - 10 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 11 IS - 1 SN - 1471-4892, 1471-4892 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Adaptations KW - Coding KW - Emotions KW - Fluoxetine KW - Genetic engineering KW - Metabolism KW - Personality KW - Reviews KW - Serotonin KW - Serotonin transporter KW - pharmacogenomics KW - Primates KW - W 30925:Genetic Engineering KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902342606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Pharmacology&rft.atitle=Human+serotonin+transporter+gene+%28SLC6A4%29+variants%3A+their+contributions+to+understanding+pharmacogenomic+and+other+functional+G+x+G+and+G+x+E+differences+in+health+and+disease&rft.au=Murphy%2C+Dennis+L%3BMoya%2C+Pablo+R&rft.aulast=Murphy&rft.aufirst=Dennis&rft.date=2011-02-01&rft.volume=11&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Pharmacology&rft.issn=14714892&rft_id=info:doi/10.1016%2Fj.coph.2011.02.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Fluoxetine; Coding; Emotions; Adaptations; pharmacogenomics; Reviews; Genetic engineering; Personality; Serotonin transporter; Metabolism; Serotonin; Primates DO - http://dx.doi.org/10.1016/j.coph.2011.02.008 ER - TY - JOUR T1 - Reflections on the need for continued research on writing AN - 902094588; 201111875 AB - A focused scientific research effort on writing research and its relationship to language development and reading is needed to address the writing and broader literacy needs of today's and tomorrow's learners and workers. In the United States, as well as in many other nations, research on writing has been neglected in relation to the emphasis on reading and oral language more generally. The authors argue first for why there is a need for this refocused effort, what should be focused on, and how as a field we should consider moving forward and addressing this imperative. In addressing the why, the authors argue that need is not limited to a particular age or developmental range but rather is broad-based, beginning with our youngest learners and continuing through those transitioning into post-secondary and the workplace. The clear message is that the picture is surprisingly similar across age ranges with a demonstrated need beginning with those coming from less advantaged backgrounds into formal education to the majority of students transitioning from twelfth grade into the workplace or post secondary settings. The authors suggest next steps for research addressing both what and how: what areas of science are areas of high need and how the field may consider moving forward to address these needs. Interdisciplinary research on writing is needed that addresses and integrates cognitive, biological, and social-cultural traditions, contributions, and methods. Adapted from the source document JF - Reading and Writing AU - Miller, Brett AU - McCardle, Peggy AD - US Department of Health and Human Services, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Bethesda, MD millerbre@mail.nih.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 121 EP - 132 VL - 24 IS - 2 SN - 0922-4777, 0922-4777 KW - Education (20900) KW - Writing (98550) KW - Reading Writing Relationship (71650) KW - Research Design (72950) KW - article KW - 4712: theory of linguistics; research design, methodology, and tools KW - 4121: applied linguistics; writing: instruction, acquisition, processes, and testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902094588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reading+and+Writing&rft.atitle=Reflections+on+the+need+for+continued+research+on+writing&rft.au=Miller%2C+Brett%3BMcCardle%2C+Peggy&rft.aulast=Miller&rft.aufirst=Brett&rft.date=2011-02-01&rft.volume=24&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Reading+and+Writing&rft.issn=09224777&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-09-27 N1 - CODEN - REWRE8 N1 - SubjectsTermNotLitGenreText - Writing (98550); Reading Writing Relationship (71650); Education (20900); Research Design (72950) ER - TY - JOUR T1 - Internal Consistency, Retest Reliability, and Their Implications for Personality Scale Validity AN - 902084273; 201122168 AB - The authors examined data (N = 34,108) on the differential reliability and validity of facet scales from the NEO Inventories. They evaluated the extent to which (a) psychometric properties of facet scales are generalizable across ages, cultures, and methods of measurement, and, (b) validity criteria are associated with different forms of reliability. Composite estimates of facet scale stability, heritability, and cross-observer validity were broadly generalizable. Two estimates of retest reliability were independent predictors of the three validity criteria; none of three estimates of internal consistency was. Available evidence suggests the same pattern of results for other personality inventories. Internal consistency of scales can be useful as a check on data quality but appears to be of limited utility for evaluating the potential validity of developed scales, and it should not be used as a substitute for retest reliability. Further research on the nature and determinants of retest reliability is needed. Adapted from the source document. JF - Personality and Social Psychology Review AU - McCrae, Robert R AU - Kurtz, John E AU - Yamagata, Shinji AU - Terracciano, Antonio AD - National Institute on Aging, National Institutes of Health, U.S. Department of Health and Human Services, Baltimore, MD Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 28 EP - 50 PB - Sage Publications, Thousand Oaks CA VL - 15 IS - 1 SN - 1088-8683, 1088-8683 KW - reliability validity cross-national five-factor model personality traits KW - Validity KW - Personality KW - Data Quality KW - article KW - 0312: social psychology; personality & social roles (individual traits, social identity, adjustment, conformism, & deviance) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902084273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personality+and+Social+Psychology+Review&rft.atitle=Internal+Consistency%2C+Retest+Reliability%2C+and+Their+Implications+for+Personality+Scale+Validity&rft.au=McCrae%2C+Robert+R%3BKurtz%2C+John+E%3BYamagata%2C+Shinji%3BTerracciano%2C+Antonio&rft.aulast=McCrae&rft.aufirst=Robert&rft.date=2011-02-01&rft.volume=15&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Personality+and+Social+Psychology+Review&rft.issn=10888683&rft_id=info:doi/10.1177%2F1088868310366253 LA - English DB - Sociological Abstracts N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-28 N1 - CODEN - PSPRFG N1 - SubjectsTermNotLitGenreText - Personality; Validity; Data Quality DO - http://dx.doi.org/10.1177/1088868310366253 ER - TY - JOUR T1 - Mapping proteoglycan-bound water in cartilage: Improved specificity of matrix assessment using multiexponential transverse relaxation analysis AN - 883041526; 15255952 AB - Association of MR parameters with cartilage matrix components remains an area of ongoing investigation. Multiexponential analysis of nonlocalized transverse relaxation data has previously been used to quantify water compartments associated with matrix macromolecules in cartilage. We extend this to mapping the proteoglycan (PG)-bound water fraction in cartilage, using mature and young bovine nasal cartilage model systems, toward the goal of matrix component-specific imaging. PG-bound water fraction from mature and young bovine nasal cartilage was 0.31 +/- 0.04 and 0.22 +/- 0.06, respectively, in agreement with biochemically derived PG content and PG-to-water weight ratios. Fourier transform infrared imaging spectroscopic-derived PG maps normalized by water content (IR-PGww) showed spatial correspondence with PG-bound water fraction maps. Extensive simulation analysis demonstrated that the accuracy and precision of our determination of PG-bound water fraction was within 2%, which is well-within the observed tissue differences. Our results demonstrate the feasibility of performing imaging-based multiexponential analysis of transverse relaxation data to map PG in cartilage. Magn Reson Med, 2011. [copy 2010 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Reiter, David A AU - Roque, Remigio A AU - Lin, Ping-Chang AU - Irrechukwu, Onyi AU - Doty, Stephen AU - Longo, Dan L AU - Pleshko, Nancy AU - Spencer, Richard G AD - Magnetic Resonance Imaging and Spectroscopy Section, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA, reiterda@mail.nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 377 EP - 384 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 65 IS - 2 SN - 1522-2594, 1522-2594 KW - Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Cartilage KW - Data processing KW - Macromolecules KW - Mapping KW - N.M.R. KW - Proteoglycans KW - Water content KW - W 30910:Imaging KW - T 2030:Cartilage and Cartilage Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883041526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Mapping+proteoglycan-bound+water+in+cartilage%3A+Improved+specificity+of+matrix+assessment+using+multiexponential+transverse+relaxation+analysis&rft.au=Reiter%2C+David+A%3BRoque%2C+Remigio+A%3BLin%2C+Ping-Chang%3BIrrechukwu%2C+Onyi%3BDoty%2C+Stephen%3BLongo%2C+Dan+L%3BPleshko%2C+Nancy%3BSpencer%2C+Richard+G&rft.aulast=Reiter&rft.aufirst=David&rft.date=2011-02-01&rft.volume=65&rft.issue=2&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22673 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22673/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-06-29 N1 - SubjectsTermNotLitGenreText - Proteoglycans; Macromolecules; Data processing; Cartilage; N.M.R.; Mapping; Water content DO - http://dx.doi.org/10.1002/mrm.22673 ER - TY - JOUR T1 - Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1-13C]pyruvate and 13C magnetic resonance spectroscopic imaging AN - 883015822; 15255973 AB - We show here that hyperpolarized [1-13C]pyruvate can be used to detect treatment response in a glioma tumor model; a tumor type where detection of response with 18fluoro-2-deoxyglucose, using positron emission tomography, is limited by the high background signals from normal brain tissue. 13C chemical shift images acquired following intravenous injection of hyperpolarized [1-13C]pyruvate into rats with implanted C6 gliomas showed significant labeling of lactate within the tumors but comparatively low levels in surrounding brain.Labeled pyruvate was observed at high levels in blood vessels above the brain and from other major vessels elsewhere but was detected at only low levels in tumor and brain.The ratio of hyperpolarized 13C label in tumor lactate compared to the maximum pyruvate signal in the blood vessels was decreased from 0.38 +/- 0.16 to 0.23 +/- 0.13, (a reduction of 34%) by 72 h following whole brain irradiation with 15 Gy. Magn Reson Med, 2011. [copy 2010 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Day, Sam E AU - Kettunen, Mikko I AU - Cherukuri, Murali Krishna AU - Mitchell, James B AU - Lizak, Martin J AU - Morris, H Douglas AU - Matsumoto, Shingo AU - Koretsky, Alan P AU - Brindle, Kevin M AD - Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA, kmb1001@cam.ac.uk Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 557 EP - 563 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 65 IS - 2 SN - 1522-2594, 1522-2594 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Intravenous administration KW - Magnetic resonance imaging KW - Animal models KW - Brain KW - Radiotherapy KW - Tumors KW - Brain tumors KW - Pyruvic acid KW - Radiation KW - Blood vessels KW - Magnetic resonance spectroscopy KW - Positron emission tomography KW - Lactic acid KW - Glioma KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883015822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Detecting+response+of+rat+C6+glioma+tumors+to+radiotherapy+using+hyperpolarized+%5B1-13C%5Dpyruvate+and+13C+magnetic+resonance+spectroscopic+imaging&rft.au=Day%2C+Sam+E%3BKettunen%2C+Mikko+I%3BCherukuri%2C+Murali+Krishna%3BMitchell%2C+James+B%3BLizak%2C+Martin+J%3BMorris%2C+H+Douglas%3BMatsumoto%2C+Shingo%3BKoretsky%2C+Alan+P%3BBrindle%2C+Kevin+M&rft.aulast=Day&rft.aufirst=Sam&rft.date=2011-02-01&rft.volume=65&rft.issue=2&rft.spage=557&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22698 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22698/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Intravenous administration; Neuroimaging; Magnetic resonance imaging; Brain; Animal models; Radiotherapy; Tumors; Brain tumors; Pyruvic acid; Blood vessels; Radiation; Magnetic resonance spectroscopy; Lactic acid; Positron emission tomography; Glioma DO - http://dx.doi.org/10.1002/mrm.22698 ER - TY - JOUR T1 - Ferritin Enhances SPIO Tracking of C6 Rat Glioma Cells by MRI AN - 883013451; 14229213 AB - Purpose: To investigate the effect of ferritin protein overexpression on superparamagnetic iron oxide (SPIO) particle labeling of C6 rat glioma cells, and track the labeled cells in vivo using magnetic resonance imaging (MRI). Materials and Methods: A plasmid of H-chain of murine ferritin gene was constructed and transfected into C6 cells. The parental and the transfected C6 cells labeled with SPIO were bilaterally inoculated subcutaneously into nude mice. The mice were imaged by multiple T2-weighted MR scans after C6 cell inoculation. The mice were killed 2weeks later, and the concentration of iron in the tumor tissue was measured by inductively coupled plasma. Results: The iron concentration in xenografts derived from SPIO-labeled C6 cells that were transfected with ferritin plasmid was significantly higher than that in xenografts from parental C6 cells that were labeled with SPIO but not transfected (p=0.034, N=5). Ferritin-transfected C6 cells showed an improved T sub(2) contrast in vivo compared with parental cells labeled with SPIO but not transfected. Conclusion: Coordinating ferritin with SPIO can lead to a longer MRI cellular tracking period. JF - Molecular Imaging and Biology AU - Wang, Jiandong AU - Xie, Jin AU - Zhou, Xiaojun AU - Cheng, Zhen AU - Gu, Ning AU - Teng, Gaojun AU - Hu, Qiujue AU - Zhu, Feipeng AU - Chang, Shuanghui AU - Zhang, Fan AU - Lu, Guangming AU - Chen, Xiaoyuan AD - Laboratory for Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 31 Center Drive, Suite 1C14 MSC 2281, Bethesda, MD, 20892-2281, USA Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 87 EP - 93 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 13 IS - 1 SN - 1536-1632, 1536-1632 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - iron oxides KW - Magnetic resonance imaging KW - Glioma cells KW - Inoculation KW - Ferritin KW - Xenografts KW - Tumors KW - Plasmids KW - Iron KW - N3 11023:Neurogenetics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883013451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Imaging+and+Biology&rft.atitle=Ferritin+Enhances+SPIO+Tracking+of+C6+Rat+Glioma+Cells+by+MRI&rft.au=Wang%2C+Jiandong%3BXie%2C+Jin%3BZhou%2C+Xiaojun%3BCheng%2C+Zhen%3BGu%2C+Ning%3BTeng%2C+Gaojun%3BHu%2C+Qiujue%3BZhu%2C+Feipeng%3BChang%2C+Shuanghui%3BZhang%2C+Fan%3BLu%2C+Guangming%3BChen%2C+Xiaoyuan&rft.aulast=Wang&rft.aufirst=Jiandong&rft.date=2011-02-01&rft.volume=13&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Molecular+Imaging+and+Biology&rft.issn=15361632&rft_id=info:doi/10.1007%2Fs11307-010-0338-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - iron oxides; Glioma cells; Magnetic resonance imaging; Inoculation; Ferritin; Tumors; Xenografts; Plasmids; Iron DO - http://dx.doi.org/10.1007/s11307-010-0338-5 ER - TY - JOUR T1 - Comparison of super(18)F- and super(11)C-labeled aryloxyanilide analogs to measure translocator protein in human brain using positron emission tomography AN - 883013330; 14211305 AB - Purpose: Translocator protein (TSPO) is a promising biomarker for neuroinflammation. We developed two new PET ligands, super(18)F-PBR06 and super(11)C-PBR28, to image TSPOs. Although our prior studies suggest that either of the two ligands could be used to quantify TSPOs in human brain, the studies were done in different sets of subjects. In this study, we directly compared super(18)F-PBR06 and super(11)C-PBR28 in eight human subjects to determine (1) whether either ligand provides more precise measurements of TSPOs and (2) whether the higher in vitro affinity of PBR06 compared to PBR28 led to higher in vivo binding of super(18)F-PBR06 compared to super(11)C-PBR28. Methods: In vivo binding was calculated as total distribution volume (V sub(T)), using an unconstrained two-tissue compartment model. V sub(T) was corrected for plasma free fraction (f sub(P)) to measure ligand binding based on free ligand concentration in brain. Results: Both ligands measured V sub(T) with similar precision, as evidenced by similarly good identifiability. However, V sub(T) for both radioligands increased with increasing lengths of data acquisition, consistent with the accumulation of radiometabolites in brain. Despite its higher lipophilicity and higher in vitro affinity, V sub(T)/f sub(P) of super(18)F-PBR06 was similar to that of super(11)C-PBR28. Conclusion: Both super(18)F-PBR06 and super(11)C-PBR28 are similar in terms of precision, sensitivity to accumulation of radiometabolites, and magnitude of in vivo binding. Thus, selection between the two radioligands will be primarily determined by the logistical impact of the different half-lives of the two radionuclides (110 vs 20min). JF - European Journal of Nuclear Medicine and Molecular Imaging AU - Dickstein, Leah P AU - Zoghbi, Sami S AU - Fujimura, Yota AU - Imaizumi, Masao AU - Zhang, Yi AU - Pike, Victor W AU - Innis, Robert B AU - Fujita, Masahiro AD - Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B1D43, 10 Center Drive, MSC-1026, Bethesda, MD, 20892-1026, USA, FujitaM@intra.nimh.nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 352 EP - 357 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 38 IS - 2 SN - 1619-7070, 1619-7070 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Brain KW - Radioisotopes KW - Positron emission tomography KW - Nuclear medicine KW - biomarkers KW - Data acquisition KW - Inflammation KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883013330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.atitle=Comparison+of+super%2818%29F-+and+super%2811%29C-labeled+aryloxyanilide+analogs+to+measure+translocator+protein+in+human+brain+using+positron+emission+tomography&rft.au=Dickstein%2C+Leah+P%3BZoghbi%2C+Sami+S%3BFujimura%2C+Yota%3BImaizumi%2C+Masao%3BZhang%2C+Yi%3BPike%2C+Victor+W%3BInnis%2C+Robert+B%3BFujita%2C+Masahiro&rft.aulast=Dickstein&rft.aufirst=Leah&rft.date=2011-02-01&rft.volume=38&rft.issue=2&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.issn=16197070&rft_id=info:doi/10.1007%2Fs00259-010-1622-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Positron emission tomography; Radioisotopes; Brain; Nuclear medicine; biomarkers; Data acquisition; Inflammation DO - http://dx.doi.org/10.1007/s00259-010-1622-y ER - TY - JOUR T1 - Kinetic analysis in human brain of [[super]11C](R)-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: A retest study and use of an image-derived input function AN - 876250742; 15124256 AB - [[super]11C](R)-rolipram provides a measure of the density of phosphodiesterase 4 (PDE4) in brain, an enzyme that metabolizes cAMP. The aims of this study were to perform kinetic modeling of [[super]11C](R)-rolipram in healthy humans using an arterial input function and to replace this arterial input in humans with an image-derived input function. Methods: Twelve humans had two injections of [[super]11C](R)-rolipram. An image-derived input function was obtained from the carotid arteries and four blood samples. The samples were used for partial volume correction and for estimating the parent concentration using HPLC analysis. Results: An unconstrained two-compartment model and Logan analysis measured distribution volume V sub(T, with good identifiability but with moderately high retest variability (15%). Similar results were obtained using the image input (ratio image/arterial V) sub(T) = 1.00 +/- 0.06). Conclusions: Binding of [[super]11C](R)-rolipram to PDE4 can be quantified in human brain using kinetic modeling and an arterial input function. Image input function from carotid arteries provides an equally accurate and reproducible method to quantify PDE4. JF - NeuroImage AU - Zanotti-Fregonara, Paolo AU - Zoghbi, Sami S AU - Liow, Jeih-San AU - Luong, Elise AU - Boellaard, Ronald AU - Gladding, Robert L AU - Pike, Victor W AU - Innis, Robert B AU - Fujita, Masahiro AD - Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland, USA, FujitaM@intra.nimh.nih.gov Y1 - 2011/02/01/ PY - 2011 DA - 2011 Feb 01 SP - 1903 EP - 1909 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 54 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain KW - N3:11006 KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876250742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Kinetic+analysis+in+human+brain+of+%5B%5Bsuper%5D11C%5D%28R%29-rolipram%2C+a+positron+emission+tomographic+radioligand+to+image+phosphodiesterase+4%3A+A+retest+study+and+use+of+an+image-derived+input+function&rft.au=Zanotti-Fregonara%2C+Paolo%3BZoghbi%2C+Sami+S%3BLiow%2C+Jeih-San%3BLuong%2C+Elise%3BBoellaard%2C+Ronald%3BGladding%2C+Robert+L%3BPike%2C+Victor+W%3BInnis%2C+Robert+B%3BFujita%2C+Masahiro&rft.aulast=Zanotti-Fregonara&rft.aufirst=Paolo&rft.date=2011-02-01&rft.volume=54&rft.issue=3&rft.spage=1903&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.10.064 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Brain DO - http://dx.doi.org/10.1016/j.neuroimage.2010.10.064 ER - TY - JOUR T1 - Neural prediction of higher-order auditory sequence statistics AN - 876234435; 15124246 AB - During auditory perception, we are required to abstract information from complex temporal sequences such as those in music and speech. Here, we investigated how higher-order statistics modulate the neural responses to sound sequences, hypothesizing that these modulations are associated with higher levels of the peri-Sylvian auditory hierarchy. We devised second-order Markov sequences of pure tones with uniform first-order transition probabilities. Participants learned to discriminate these sequences from random ones. Magnetoencephalography was used to identify evoked fields in which second-order transition probabilities were encoded. We show that improbable tones evoked heightened neural responses after 200 ms post-tone onset during exposure at the learning stage or around 150 ms during the subsequent test stage, originating near the right temporoparietal junction. These signal changes reflected higher-order statistical learning, which can contribute to the perception of natural sounds with hierarchical structures. We propose that our results reflect hierarchical predictive representations, which can contribute to the experiences of speech and music. JF - NeuroImage AU - Furl, Nicholas AU - Kumar, Sukhbinder AU - Alter, Kai AU - Durrant, Simon AU - Shawe-Taylor, John AU - Griffiths, Timothy D AD - Department of Computer Science, University College London, London, WC1E 6BT, UK, furlno@mail.nih.gov Y1 - 2011/02/01/ PY - 2011 DA - 2011 Feb 01 SP - 2267 EP - 2277 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 54 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Auditory perception KW - Statistics KW - W 30910:Imaging KW - N3:11001 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876234435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Neural+prediction+of+higher-order+auditory+sequence+statistics&rft.au=Furl%2C+Nicholas%3BKumar%2C+Sukhbinder%3BAlter%2C+Kai%3BDurrant%2C+Simon%3BShawe-Taylor%2C+John%3BGriffiths%2C+Timothy+D&rft.aulast=Furl&rft.aufirst=Nicholas&rft.date=2011-02-01&rft.volume=54&rft.issue=3&rft.spage=2267&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.10.038 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Statistics DO - http://dx.doi.org/10.1016/j.neuroimage.2010.10.038 ER - TY - JOUR T1 - A Prospective Study of Pediatric Loss of Control Eating and Psychological Outcomes AN - 875713575; 201113505 AB - Loss of control (LOC) eating in youth is associated cross-sectionally with eating-related and psychosocial distress and is predictive of excessive weight gain. However, few longitudinal studies have examined the psychological impact and persistence of pediatric LOC eating. We administered the Eating Disorder Examination and self-reported measures of depressive and anxiety symptoms to 195 boys and girls (mean age = 10.4 years, SD = 1.5) at baseline and again 4.7 years (SD = 1.2) later to 118 of these youth. Missing data were imputed. Baseline report of LOC was associated with the development of partial- or full-syndrome binge eating disorder (p = .03), even after accounting for the contribution of sex, race, baseline characteristics (age, disordered eating attitudes, and mood symptoms), body mass index growth between baseline and follow-up, and years in study. Half (52.2%; 95% CI [1.15, 6.22]) of children who endorsed experiencing LOC at baseline reported persistence of LOC at follow-up (p = .02). Compared with children who never reported LOC eating or reported LOC only at baseline, those with persistent LOC experienced significantly greater increases in disordered eating attitudes (p@s < .001) and depressive symptoms (p = .027) over time. These data suggest that LOC eating in children is a problematic behavior that frequently persists into adolescence and that persistent LOC eating is associated with worsening of emotional distress. [Copyright American Psychological Association] JF - Journal of Abnormal Psychology AU - Tanofsky-Kraff, Marian AU - Shomaker, Lauren B AU - Olsen, Cara AU - Roza, Caroline A AU - Wolkoff, Laura E AU - Columbo, Kelli M AU - Raciti, Gina AU - Zocca, Jaclyn M AU - Wilfley, Denise E AU - Yanovski, Susan Z AU - Yanovski, Jack A AD - Section on Growth and Obesity, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 108 EP - 118 PB - American Psychological Association, Washington DC VL - 120 IS - 1 SN - 0021-843X, 0021-843X KW - binge eating disorder loss of control eating depression childhood adolescence KW - Eating KW - Symptoms KW - Paediatrics KW - Eating disorders KW - Young people KW - Children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875713575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Abnormal+Psychology&rft.atitle=A+Prospective+Study+of+Pediatric+Loss+of+Control+Eating+and+Psychological+Outcomes&rft.au=Tanofsky-Kraff%2C+Marian%3BShomaker%2C+Lauren+B%3BOlsen%2C+Cara%3BRoza%2C+Caroline+A%3BWolkoff%2C+Laura+E%3BColumbo%2C+Kelli+M%3BRaciti%2C+Gina%3BZocca%2C+Jaclyn+M%3BWilfley%2C+Denise+E%3BYanovski%2C+Susan+Z%3BYanovski%2C+Jack+A&rft.aulast=Tanofsky-Kraff&rft.aufirst=Marian&rft.date=2011-02-01&rft.volume=120&rft.issue=1&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=Journal+of+Abnormal+Psychology&rft.issn=0021843X&rft_id=info:doi/10.1037%2Fa0021406 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-07-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JABCAA N1 - SubjectsTermNotLitGenreText - Eating; Children; Eating disorders; Paediatrics; Symptoms; Young people DO - http://dx.doi.org/10.1037/a0021406 ER - TY - JOUR T1 - 'Is it okay to eat a dog in Korea ... like China?' Assumptions of national food-eating practices in intercultural interaction AN - 875712762; 201107725 AB - There is a small body of research which shows how intercultural communication is constituted in and through talk-in-interaction, and can be made relevant or irrelevant by interactants on a moment-by-moment basis. Our paper builds on this literature by investigating how cultural assumptions of national food-eating practices are deployed, contested and co-constructed in an online, voice-based chat room. Using conversation analysis, findings show how assumptions about cultural practices sequentially unfold in a setting where the interactants are strangers. Additionally, we show how assumptions about cultural practices can be used for rhetorical purposes, and can be treated as simple and complex in a single exchange. Adapted from the source document JF - Language and Intercultural Communication AU - Jenks, Christopher AU - Brandta, Adam AD - School of Education, Communication and Language Sciences, Newcastle University, King George VI Building, Queen Victoria Road, Newcastle upon Tyne NEI 8ST, UK adam.brandt@newcastle.ac.uk Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 41 EP - 58 VL - 11 IS - 1 SN - 1470-8477, 1470-8477 KW - Conversation Analysis (15605) KW - Cross Cultural Communication (16300) KW - Interpersonal Communication (37700) KW - Cultural Factors (16500) KW - Cultural Differences (16400) KW - article KW - 5516: interpersonal behavior and communication; cross-cultural communication and behavior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875712762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Language+and+Intercultural+Communication&rft.atitle=%27Is+it+okay+to+eat+a+dog+in+Korea+...+like+China%3F%27+Assumptions+of+national+food-eating+practices+in+intercultural+interaction&rft.au=Jenks%2C+Christopher%3BBrandta%2C+Adam&rft.aulast=Jenks&rft.aufirst=Christopher&rft.date=2011-02-01&rft.volume=11&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Language+and+Intercultural+Communication&rft.issn=14708477&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2011-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Cross Cultural Communication (16300); Cultural Differences (16400); Cultural Factors (16500); Conversation Analysis (15605); Interpersonal Communication (37700) ER - TY - JOUR T1 - Investigating the Potential for Toxicity from Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle AN - 874188198; 14813478 AB - Two-year toxicity studies were conducted on the widely used herbal products, goldenseal and milk thistle, in male and female F344/N rats and B6C3F1 mice. With goldenseal root powder, the primary finding was an increase in liver tumors in rats and mice, and with milk thistle extract, a decrease in spontaneous background tumors including mammary gland tumors in female rats and liver tumors in male mice. Increased tumorigenicity in rodents exposed to goldenseal root powder may be due in part to the topoisomerase inhibition properties of berberine, a major alkaloid constituent in goldenseal, or its metabolite, berberrubine. In the clinic, use of topoisomerase-inhibiting agents has been associated with secondary tumor formation and inhibition in DNA repair processes. In contrast, the radical-scavenging and antioxidant properties of silibinin and other flavonolignans in milk thistle extract may have contributed to the decrease in background tumors in rodents in the present studies. The fate of the active constituents of goldenseal and milk thistle is similar in humans and rodents; therefore, the modes of action may translate across species. Further studies are needed to extrapolate the findings to humans. JF - Toxicologic Pathology AU - Dunnick, June K AU - Singh, Bhanu AU - Nyska, Abraham AU - Peckham, John AU - Kissling, Grace E AU - Sanders, JMichael AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA, dunnickj@niehs.nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 398 EP - 409 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 39 IS - 2 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Powder KW - Antioxidants KW - Milk KW - Mammary gland KW - Tumorigenicity KW - Roots KW - Metabolites KW - Toxicity KW - Tumors KW - DNA repair KW - Alkaloids KW - silibinin KW - Liver KW - Berberine KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874188198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Investigating+the+Potential+for+Toxicity+from+Long-Term+Use+of+the+Herbal+Products%2C+Goldenseal+and+Milk+Thistle&rft.au=Dunnick%2C+June+K%3BSingh%2C+Bhanu%3BNyska%2C+Abraham%3BPeckham%2C+John%3BKissling%2C+Grace+E%3BSanders%2C+JMichael&rft.aulast=Dunnick&rft.aufirst=June&rft.date=2011-02-01&rft.volume=39&rft.issue=2&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623310394211 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Powder; Milk; Antioxidants; Mammary gland; Roots; Tumorigenicity; Metabolites; Tumors; Toxicity; DNA repair; Alkaloids; Liver; silibinin; Berberine DO - http://dx.doi.org/10.1177/0192623310394211 ER - TY - JOUR T1 - Induced dispersal in wildlife management: experimental evaluation of the risk of hybrid breakdown and the benefit of hybrid vigor in the F1 generation AN - 874183392; 14210175 AB - Management practices often aim to increase the level of gene flow by either: introducing animals from captive breeding programs, translocating animals from abundant areas, or increasing the chance of animals dispersing between populations by creating habitat corridors. These practices provide opportunity for the hybrid offspring of introduced and resident animals to experience either increased fitness (hybrid vigor) or decreased fitness (hybrid breakdown). There is very little quantitative data available to adequately assess whether hybridization is likely to be beneficial or detrimental to populations managed in these ways. Using Drosophila melanogaster populations, we conducted two experiments that simulate the common management practices of translocation and wildlife habitat corridors. We monitored the frequency and magnitude of hybrid vigor and hybrid breakdown in F1 hybrids to assess the relative risks and benefits to populations and also monitored net productivity (number of adults produced from controlled crosses) to assess whether the populations were stable or in decline. In the translocation experiment, we observed instances of both significant hybrid vigor and hybrid breakdown, both occurring at a frequency of 9%. In the habitat corridor experiments, populations with moderate to high dispersal (1-4% per generation) did not develop significant hybrid vigor or hybrid breakdown. However, of the populations experiencing low dispersal (0.25% per generation) for 34 generations, 6% displayed significant hybrid vigor and 6% displayed significant hybrid breakdown. These results suggest that in first generation hybrids there may be limited opportunity to utilize hybrid vigor as a tool to increase the short-term viability of populations because there is an equal likelihood of encountering hybrid breakdown that may drive the population into further decline. However, our results apply only to populations of moderate size (N=50; N sub(e)=14.3) in the absence of deliberate consanguineous mating. Lastly, we observed that net productivity was positively correlated with dispersal rate, suggesting that initial F1 declines in fitness may be temporary and that it is preferable to maintain high levels of selectable variation via induced dispersal to assist the long-term survival of vulnerable populations. JF - Conservation Genetics AU - Holleley, Clare E AU - Nichols, Richard A AU - Whitehead, Michael R AU - Gunn, Melissa R AU - Gupta, Jyoutsna AU - Sherwin, William B AD - Evolution & Ecology Research Centre and School of Biological, Earth & Environmental Sciences, University of New South Wales, Sydney, NSW, 2052, Australia, holleleyce@mail.nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 31 EP - 40 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 12 IS - 1 SN - 1566-0621, 1566-0621 KW - Sustainability Science Abstracts; Ecology Abstracts; Genetics Abstracts KW - Fitness KW - Wildlife management KW - Survival KW - Hybrid vigor KW - dispersal KW - Cost-benefit analysis KW - Mating KW - Gene flow KW - Habitat corridors KW - Translocation KW - offspring KW - Data processing KW - Wildlife KW - Habitat KW - Captive breeding KW - hybrids KW - Drosophila melanogaster KW - vulnerability KW - translocation KW - Dispersal KW - survival KW - Conservation genetics KW - Genetic crosses KW - M3 1010:Issues in Sustainable Development KW - G 07750:Ecological & Population Genetics KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874183392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Conservation+Genetics&rft.atitle=Induced+dispersal+in+wildlife+management%3A+experimental+evaluation+of+the+risk+of+hybrid+breakdown+and+the+benefit+of+hybrid+vigor+in+the+F1+generation&rft.au=Holleley%2C+Clare+E%3BNichols%2C+Richard+A%3BWhitehead%2C+Michael+R%3BGunn%2C+Melissa+R%3BGupta%2C+Jyoutsna%3BSherwin%2C+William+B&rft.aulast=Holleley&rft.aufirst=Clare&rft.date=2011-02-01&rft.volume=12&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Conservation+Genetics&rft.issn=15660621&rft_id=info:doi/10.1007%2Fs10592-009-9984-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Fitness; Wildlife management; Data processing; Wildlife; Survival; Hybrid vigor; Captive breeding; Cost-benefit analysis; Mating; Gene flow; Habitat corridors; Dispersal; Translocation; Genetic crosses; Conservation genetics; hybrids; vulnerability; translocation; survival; Habitat; dispersal; offspring; Drosophila melanogaster DO - http://dx.doi.org/10.1007/s10592-009-9984-z ER - TY - JOUR T1 - Chronic Progressive Nephropathy in Male F344 Rats in 90-Day Toxicity Studies: Its Occurrence and Association with Renal Tubule Tumors in Subsequent 2-Year Bioassays AN - 874181736; 14813471 AB - The occurrence and severity of spontaneous chronic progressive nephropathy (CPN) in control male F344 rats as well as the frequency of treatment-related CPN exacerbation were histopathologically reevaluated. A series of 43 National Toxicology Program (NTP) 90-day toxicity studies comparing the influence of NIH-07 or NTP-2000 diets was examined. Relationships between the histopathologic findings at 90 days and renal tubule proliferative lesions recorded in subsequent 2-year bioassays for 24 chemicals were statistically analyzed. CPN lesions were observed in 100% of the control male rats regardless of diet, but CPN was more severe in control rats fed NIH-07. Approximately one-third of the 90-day studies demonstrated a treatment-related exacerbation of CPN severity, which was independent of diet. For chemicals that proceeded to 2-year bioassays, all studies with a statistically significant increase in renal tubule tumors (RTT) at 2 years had treatment-related exacerbation of CPN in the 90-day and 2-year studies. These findings indicate that CPN occurs ubiquitously in young male F344 rats and that treatment-related exacerbation of CPN in 90-day studies is a relatively common occurrence, having the potential to be predictive of an increased incidence of RTT in subsequent 2-year bioassays. JF - Toxicologic Pathology AU - Travlos, Greg S AU - Hard, Gordon C AU - Betz, Laura J AU - Kissling, Grace E AD - National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA, travlos@niehs.nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 381 EP - 389 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 39 IS - 2 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Diets KW - renal tubules KW - Nephropathy KW - Statistical analysis KW - Toxicity KW - Tumors KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874181736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Chronic+Progressive+Nephropathy+in+Male+F344+Rats+in+90-Day+Toxicity+Studies%3A+Its+Occurrence+and+Association+with+Renal+Tubule+Tumors+in+Subsequent+2-Year+Bioassays&rft.au=Travlos%2C+Greg+S%3BHard%2C+Gordon+C%3BBetz%2C+Laura+J%3BKissling%2C+Grace+E&rft.aulast=Travlos&rft.aufirst=Greg&rft.date=2011-02-01&rft.volume=39&rft.issue=2&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623310388432 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diets; renal tubules; Nephropathy; Statistical analysis; Tumors; Toxicity DO - http://dx.doi.org/10.1177/0192623310388432 ER - TY - JOUR T1 - Colorectal cancer after breast cancer: A case-control study AN - 872131961; 14512717 AB - Introduction: The risk of colorectal cancer (CRC) after BC and the additional risk factor of tamoxifen exposure were investigated by several studies with conflicting results. We performed a case-control study aimed at investigating if a past history of breast cancer is a risk factor of developing adenomas or CRC and establishing whether tamoxifen exposure is an additional risk factor. Materials and methods: We enrolled 175 asymptomatic women with a past history of BC and invited them to undergo a screening colonoscopy. In the same period, we enrolled 201 healthy asymptomatic women (HG) with no family history of CRC which were referred to our Unit for a colonoscopy. Results: Mean age at colonoscopy was 56.9 years for BC patients vs. 56.3 years for HG (p =0.58). In 32/175 (18.3%) BC patients, 38 lesions and in 17/201 (8.4%) controls, 20 lesions (p =0.029) were diagnosed. BC patients had 5/32 CRC vs. no CRC in the HG. Multivariate analysis of age, family history of CRC, timing from BC diagnosis and first colonoscopy, tamoxifen treatment revealed that none of the variables were predictive of the presence or absence of adenomas or CRC in the BC group. Discussion: In the present study BC group had a significant higher prevalence of adenoma or CRC than controls. Tamoxifen exposure did not increase the risk of adenoma or CRC. Our data support the hypothesis that BC is a risk condition for adenomas or CRC. The risk is small but present and a screening colonoscopy should be offered to these patients. JF - Cancer Epidemiology AU - Sanchez-Mete, Lupe AU - Venturo, Irene AU - Papaldo, Paola AU - Sperduti, Isabella AU - Stigliano, Vittoria AD - Gastroenterology and Digestive Endoscopic Unit, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 44 EP - 47 PB - Elsevier Science Ltd., The Boulevard Kidlington Oxford OX5 1GB UK VL - 35 IS - 1 SN - 1877-7821, 1877-7821 KW - Risk Abstracts KW - Historical account KW - Age KW - Cancer KW - Genetics KW - colorectal carcinoma KW - Breast cancer KW - Lesions KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872131961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology&rft.atitle=Colorectal+cancer+after+breast+cancer%3A+A+case-control+study&rft.au=Sanchez-Mete%2C+Lupe%3BVenturo%2C+Irene%3BPapaldo%2C+Paola%3BSperduti%2C+Isabella%3BStigliano%2C+Vittoria&rft.aulast=Sanchez-Mete&rft.aufirst=Lupe&rft.date=2011-02-01&rft.volume=35&rft.issue=1&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology&rft.issn=18777821&rft_id=info:doi/10.1016%2Fj.canep.2010.09.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Historical account; Genetics; Age; colorectal carcinoma; Lesions; Breast cancer; Cancer DO - http://dx.doi.org/10.1016/j.canep.2010.09.002 ER - TY - JOUR T1 - Product Biomonitoring and Responsible Reporting AN - 869799184; 14444562 AB - Abstract not available. JF - Environmental Health Perspectives AU - Jung, Paul AD - Chief of Staff, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, jungp@niehs.nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - A58 EP - A59 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 119 IS - 2 SN - 0091-6765, 0091-6765 KW - Environment Abstracts KW - Bioindicators KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869799184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Product+Biomonitoring+and+Responsible+Reporting&rft.au=Jung%2C+Paul&rft.aulast=Jung&rft.aufirst=Paul&rft.date=2011-02-01&rft.volume=119&rft.issue=2&rft.spage=A58&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1003355 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Bioindicators DO - http://dx.doi.org/10.1289/ehp.1003355 ER - TY - JOUR T1 - Reflectance spectroscopy; a new approach for reconstructing penguin population size from Antarctic ornithogenic sediments AN - 869789750; 2011-050105 AB - Reflectance spectroscopy has several advantages compared to traditional chemical methods in paleolimnology. It requires little cost, involves minimal or no sample preparation and is rapid. There has, however, been limited use of reflectance spectroscopy in polar paleolimnological studies. This paper explores the application of reflectance spectroscopy to reconstruct historical changes in penguin population size in the maritime Antarctic. Two ornithogenic sediment cores on Ardley Island, Antarctica were analyzed. Penguin droppings and weathered soils were analyzed as reference materials. Principal component analysis and linear mixing modeling were performed on the spectral data to estimate the proportion of penguin guano in the sediments and these values were used to infer historical penguin population numbers. Historical penguin population size versus time, reconstructed from reflectance spectra, and population numbers inferred from previous geochemical analysis of bio-elements, were quite similar. Our results illustrate the feasibility of rapidly inferring historical changes in penguin population size using reflectance spectroscopy on Antarctic ornithogenic sediments. Our findings suggest that this technique has potential for reconstructing past population numbers of other seabirds and mammals using lake sediments influenced by animal excrement. Copyright 2011 Springer Science+Business Media B.V. JF - Journal of Paleolimnology AU - Liu, Xiaodong AU - Sun, Jing AU - Sun, Liguang AU - Liu, Wenqi AU - Wang, Yuhong Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 213 EP - 222 PB - Springer, Dordrecht VL - 45 IS - 2 SN - 0921-2728, 0921-2728 KW - Holocene KW - Ardley Island KW - guano KW - Cenozoic KW - South Shetland Islands KW - sediments KW - chemical composition KW - Neornithes KW - Chordata KW - Quaternary KW - principal components analysis KW - statistical analysis KW - Aves KW - populations KW - paleoenvironment KW - Antarctica KW - Sphenisciformes KW - lacustrine environment KW - Vertebrata KW - upper Holocene KW - Scotia Sea Islands KW - reflectance KW - Tetrapoda KW - lake sediments KW - 11:Vertebrate paleontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869789750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Paleolimnology&rft.atitle=Reflectance+spectroscopy%3B+a+new+approach+for+reconstructing+penguin+population+size+from+Antarctic+ornithogenic+sediments&rft.au=Liu%2C+Xiaodong%3BSun%2C+Jing%3BSun%2C+Liguang%3BLiu%2C+Wenqi%3BWang%2C+Yuhong&rft.aulast=Liu&rft.aufirst=Xiaodong&rft.date=2011-02-01&rft.volume=45&rft.issue=2&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Journal+of+Paleolimnology&rft.issn=09212728&rft_id=info:doi/10.1007%2Fs10933-010-9493-6 L2 - http://www.springerlink.com/(i42ivkufd5oczp45mspwbbyb)/app/home/journal.asp?referrer=parent&backto=linkingpublicationresults,1:100294,1 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by Springer Verlag, Berlin, Federal Republic of Germany N1 - Date revised - 2011-01-01 N1 - Number of references - 50 N1 - Document feature - illus. incl. sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Antarctica; Ardley Island; Aves; Cenozoic; chemical composition; Chordata; guano; Holocene; lacustrine environment; lake sediments; Neornithes; paleoenvironment; populations; principal components analysis; Quaternary; reflectance; Scotia Sea Islands; sediments; South Shetland Islands; Sphenisciformes; statistical analysis; Tetrapoda; upper Holocene; Vertebrata DO - http://dx.doi.org/10.1007/s10933-010-9493-6 ER - TY - JOUR T1 - Intravital microscopy as a tool to study drug delivery in preclinical studies AN - 869585525; 14816634 AB - The technical developments in the field of non-linear microscopy have made intravital microscopy one of the most successful techniques for studying physiological and pathological processes in live animals. Intravital microscopy has been utilized to address many biological questions in basic research and is now a fundamental tool for preclinical studies, with an enormous potential for clinical applications. The ability to dynamically image cellular and subcellular structures combined with the possibility to perform longitudinal studies have empowered investigators to use this discipline to study the mechanisms of action of therapeutic agents and assess the efficacy on their targets in vivo. The goal of this review is to provide a general overview of the recent advances in intravital microscopy and to discuss some of its applications in preclinical studies. JF - Advanced Drug Delivery Reviews AU - Amornphimoltham, Panomwat AU - Masedunskas, Andrius AU - Weigert, Roberto AD - Intracellular Membrane Trafficking Unit, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institute of Health, 30 Convent drive, Room 303A, Bethesda, MD 20892-4340, USA, weigertr@mail.nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 119 EP - 128 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 63 IS - 1-2 SN - 0169-409X, 0169-409X KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Microscopy KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869585525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Drug+Delivery+Reviews&rft.atitle=Intravital+microscopy+as+a+tool+to+study+drug+delivery+in+preclinical+studies&rft.au=Amornphimoltham%2C+Panomwat%3BMasedunskas%2C+Andrius%3BWeigert%2C+Roberto&rft.aulast=Amornphimoltham&rft.aufirst=Panomwat&rft.date=2011-02-01&rft.volume=63&rft.issue=1-2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Advanced+Drug+Delivery+Reviews&rft.issn=0169409X&rft_id=info:doi/10.1016%2Fj.addr.2010.09.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Microscopy DO - http://dx.doi.org/10.1016/j.addr.2010.09.009 ER - TY - JOUR T1 - Understanding the effects of carbocyclic sugars constrained to north and south conformations on RNA nanodesign AN - 864958869; 14365816 AB - The use of modified nucleotides impacts RNA conformations and their flexibilities. North and south constrained sugars induce structural changes. South constrained sugars induce local structural changes in RNA to B-form helices. North constrained sugars in HIV kissing loops reduce structural flexibility. Large external forces are required to deform RNA containing constrained sugars. Relatively new types of the modified nucleotides, namely carbocyclic sugars that are constrained to north or south (C2a super(2) or C3a super(2) exo) conformations, can be used for RNA nanoparticle design to control their structures and stability by rigidifying nucleotides and altering the helical properties of RNA duplexes. Two RNA structures, an RNA dodecamer and an HIV kissing loop complex where several nucleotides were replaced with north or south constrained sugars, were studied by molecular dynamics (MD) simulations. The substituted south constrained nucleotides in the dodecamer widened the major groove and narrowed and deepened the minor groove thus inducing local conformational changes that resemble a B-form DNA helix. In the HIV kissing loop complex, north and south constrained nucleotides were substituted into flanking bases and stems. The modified HIV kissing loop complex showed a lower RMSD value than the normal kissing loop complex. The overall twist angle was also changed and its standard deviation was reduced. In addition, the modified RNA dodecamer and HIV kissing loop complex were characterized by principal component analysis (PCA) and steered molecular dynamics (SMD). PCA results showed that the constrained sugars stabilized the overall motions. The results of the SMD simulations indicated that as the backbone I angles were increased by elongation, more force was applied to the modified RNA due to the constrained sugar analogues. JF - Journal of Molecular Graphics and Modelling AU - Kim, Taejin AU - Barchi, Joseph J AU - Marquez, Victor E AU - Shapiro, Bruce A AD - Center for Cancer Research Nanobiology Program (CCRNP), National Cancer Institute at Frederick, Frederick, MD, USA, shapirbr@mail.nih.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 624 EP - 634 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 29 IS - 5 SN - 1093-3263, 1093-3263 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - RNA KW - North constrained sugar KW - South constrained sugar KW - Molecular dynamics simulations KW - RNA structure deformations KW - RNA nanodesign KW - Sugar KW - Stems KW - Nucleotides KW - Saccharides KW - Elongation KW - Standard deviation KW - DNA structure KW - Human immunodeficiency virus KW - Principal components analysis KW - DNA KW - nanoparticles KW - Conformation KW - W 30940:Products KW - Q5 08502:Methods and instruments KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864958869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Graphics+and+Modelling&rft.atitle=Understanding+the+effects+of+carbocyclic+sugars+constrained+to+north+and+south+conformations+on+RNA+nanodesign&rft.au=Kim%2C+Taejin%3BBarchi%2C+Joseph+J%3BMarquez%2C+Victor+E%3BShapiro%2C+Bruce+A&rft.aulast=Kim&rft.aufirst=Taejin&rft.date=2011-02-01&rft.volume=29&rft.issue=5&rft.spage=624&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Graphics+and+Modelling&rft.issn=10933263&rft_id=info:doi/10.1016%2Fj.jmgm.2010.11.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - RNA; DNA; Nucleotides; Saccharides; Elongation; Sugar; DNA structure; Standard deviation; Principal components analysis; Stems; nanoparticles; Conformation; Human immunodeficiency virus DO - http://dx.doi.org/10.1016/j.jmgm.2010.11.007 ER - TY - JOUR T1 - Docking-based virtual screening for ligands of G protein-coupled receptors: Not only crystal structures but also in silico models AN - 864420621; 14365817 AB - Display Omitted a- Explored the applicability of GPCR crystal structures to docking-based virtual screenings. a- Improved the performance of the screening through receptor ensemble docking. a- Directed the screening towards the retrieval of agonists by optimizing the structure of the receptor around bound agonists. a- Assessed the feasibility of the use of homology models in lieu of the experimental structure, in the absence of the latter. G protein-coupled receptors (GPCRs) regulate a wide range of physiological functions and hold great pharmaceutical interest. Using the beta 2-adrenergic receptor as a case study, this article explores the applicability of docking-based virtual screening to the discovery of GPCR ligands and defines methods intended to improve the screening performance. Our controlled computational experiments were performed on a compound dataset containing known agonists and blockers of the receptor as well as a large number of decoys. The screening based on the structure of the receptor crystallized in complex with its inverse agonist carazolol yielded excellent results, with a clearly delineated prioritization of ligands over decoys. Blockers generally were preferred over agonists; however, agonists were also well distinguished from decoys. A method was devised to increase the screening yields by generating an ensemble of alternative conformations of the receptor that accounts for its flexibility. Moreover, a method was devised to improve the retrieval of agonists, based on the optimization of the receptor around a known agonist. Finally, the applicability of docking-based virtual screening also to homology models endowed with different levels of accuracy was proved. This last point is of uttermost importance, since crystal structures are available only for a limited number of GPCRs, and extends our conclusions to the entire superfamily. The outcome of this analysis definitely supports the application of computer-aided techniques to the discovery of novel GPCR ligands, especially in light of the fact that, in the near future, experimental structures are expected to be solved and become available for an ever increasing number of GPCRs. JF - Journal of Molecular Graphics and Modelling AU - Vilar, Santiago AU - Ferino, Giulio AU - Phatak, Sharangdhar S AU - Berk, Barkin AU - Cavasotto, Claudio N AU - Costanzi, Stefano AD - Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA, stefanoc@mail.nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 614 EP - 623 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 29 IS - 5 SN - 1093-3263, 1093-3263 KW - Biotechnology and Bioengineering Abstracts KW - G protein-coupled receptors KW - Beta-adrenergic receptors KW - Virtual screening KW - Docking KW - Homology modeling KW - Inverse agonists KW - Homology KW - double prime G protein-coupled receptors KW - Crystal structure KW - Pharmaceuticals KW - Adrenergic receptors KW - Computer applications KW - Models KW - Conformation KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864420621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Graphics+and+Modelling&rft.atitle=Docking-based+virtual+screening+for+ligands+of+G+protein-coupled+receptors%3A+Not+only+crystal+structures+but+also+in+silico+models&rft.au=Vilar%2C+Santiago%3BFerino%2C+Giulio%3BPhatak%2C+Sharangdhar+S%3BBerk%2C+Barkin%3BCavasotto%2C+Claudio+N%3BCostanzi%2C+Stefano&rft.aulast=Vilar&rft.aufirst=Santiago&rft.date=2011-02-01&rft.volume=29&rft.issue=5&rft.spage=614&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Graphics+and+Modelling&rft.issn=10933263&rft_id=info:doi/10.1016%2Fj.jmgm.2010.11.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Inverse agonists; Homology; double prime G protein-coupled receptors; Crystal structure; Pharmaceuticals; Adrenergic receptors; Computer applications; Conformation; Models DO - http://dx.doi.org/10.1016/j.jmgm.2010.11.005 ER - TY - JOUR T1 - Stability tests on known and misfolded structures with discrete and all atom molecular dynamics simulations AN - 864416773; 14365811 AB - Display Omitted a- Discrete molecular dynamics (DMD) can identify incorrect structures. a- DMD explores considerably longer time scale than all atom molecular dynamics (MD). a- Results obtained with DMD are consistent with the results obtained with all atom MD. a- A physiological temperature was identified for DMD. The brevity of molecular dynamics simulations often limits their utility in developing and evaluating structural models of proteins. The duration of simulations can be increased greatly using discrete molecular dynamics (DMD). However, the trade off is that coarse graining, implicit solvent, and other time-saving procedures reduce the accuracy of DMD simulations. Here we address some of these issues by comparing results of DMD and conventional all atom MD simulations on proteins of known structure and misfolded proteins. DMD simulations were performed at a range of temperatures to identify a 'physiological' temperature for DMD that mimicked molecular motions of conventional MD simulations at 310K. We also compared results obtained with a new implicit solvent model developed here based on Miyazawa-Jernigan interaction pair potential to those obtained with a previously used model based on Kyte-Doolittle hydropathy scale. We compared DMD and all atom molecular dynamics with explicit water by simulating both correctly and incorrectly folded structures, and monomeric and dimeric alpha beta -barrel structures to analyze the ability of these procedures to distinguish between good and bad models. Deviations from the correct structures were substantially greater with DMD, as would be expected from coarse-graining and longer simulation time. Deviations were smallest for beta -strands and greatest for coiled loops. Structures of the incorrectly folded models were very poorly preserved during the DMD simulations; but both methods were able to distinguish between the correct and the incorrect structures based on differences in the magnitudes of the root mean squared deviation (RMSD) from the starting conformation. JF - Journal of Molecular Graphics and Modelling AU - Yun, Sijung AU - Guy, HRobert AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892-5567, USA Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 663 EP - 675 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 29 IS - 5 SN - 1093-3263, 1093-3263 KW - Biotechnology and Bioengineering Abstracts KW - Discrete molecular dynamics (DMD) KW - Stability KW - Protein modelling KW - NAMD KW - Temperature effects KW - Molecular modelling KW - Protein folding KW - Solvents KW - Models KW - Conformation KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864416773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Graphics+and+Modelling&rft.atitle=Stability+tests+on+known+and+misfolded+structures+with+discrete+and+all+atom+molecular+dynamics+simulations&rft.au=Yun%2C+Sijung%3BGuy%2C+HRobert&rft.aulast=Yun&rft.aufirst=Sijung&rft.date=2011-02-01&rft.volume=29&rft.issue=5&rft.spage=663&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Graphics+and+Modelling&rft.issn=10933263&rft_id=info:doi/10.1016%2Fj.jmgm.2010.12.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Temperature effects; Molecular modelling; Protein folding; Solvents; Conformation; Models DO - http://dx.doi.org/10.1016/j.jmgm.2010.12.002 ER - TY - JOUR T1 - Analysis of the stabilities of hexameric amyloid- beta (1-42) models using discrete molecular dynamics simulations AN - 864415184; 14365812 AB - Amyloid- beta (A beta ) oligomers appear to play a pivotal role in Alzheimer's disease. A 42 residue long alloform, A beta 42, is closely related to etiology of the disease. In vitro results show evidences of hexamers; however structures of these hexamers have not been resolved experimentally. Here, we use discrete molecular dynamics (DMD) to analyze long duration stabilities of A beta 42 hexamer models developed previously in our lab. The hydrophobic core of these models is a six-stranded beta -barrel with 3-fold radial symmetry formed by residues 30-40. This core is shielded from water by residues 1-28. The nine models we analyzed differ by the relative positions of the core beta -strands, and whether the other segments surrounding the core contain alpha helices or beta -strands. A model of an annular protofibril composed of 36 A beta peptides was also simulated. Results of these model simulations were compared with results of aggregation simulations that started from six well separated random coils of A beta 42 and with simulations of two known beta -barrel structures. These results can be categorized into three groups: stable models with properties similar or superior to those of experimentally determined beta -barrel proteins, aggregation-prone models, and an amorphous aggregate from random coils. Conformations at the end of the simulation for aggregation-prone models have exposed hydrophobic core with dangling beta -strands on the surface. Hydrogen bond patterns within the beta -barrel were a critical factor for stability of the beta -barrel models. Aggregation-prone conformations imply that the association of these hexamers may be possible, which could lead to the formation of larger assemblies. JF - Journal of Molecular Graphics and Modelling AU - Yun, Sijung AU - Yun, Sajung AU - Guy, HRobert AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892-5567, USA Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 657 EP - 662 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 29 IS - 5 SN - 1093-3263, 1093-3263 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - A beta KW - Hexamer KW - Discrete molecular dynamics KW - Protein modeling KW - Stability KW - Amyloid KW - hexamers KW - Molecular modelling KW - Neurodegenerative diseases KW - Etiology KW - Hydrogen bonding KW - Alzheimer's disease KW - Hydrophobicity KW - beta -Amyloid KW - Random coil KW - Models KW - Conformation KW - N3 11002:Computational & theoretical neuroscience KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864415184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Graphics+and+Modelling&rft.atitle=Analysis+of+the+stabilities+of+hexameric+amyloid-+beta+%281-42%29+models+using+discrete+molecular+dynamics+simulations&rft.au=Yun%2C+Sijung%3BYun%2C+Sajung%3BGuy%2C+HRobert&rft.aulast=Yun&rft.aufirst=Sijung&rft.date=2011-02-01&rft.volume=29&rft.issue=5&rft.spage=657&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Graphics+and+Modelling&rft.issn=10933263&rft_id=info:doi/10.1016%2Fj.jmgm.2010.11.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Neurodegenerative diseases; Molecular modelling; hexamers; Etiology; Hydrogen bonding; Alzheimer's disease; Hydrophobicity; beta -Amyloid; Random coil; Conformation; Models DO - http://dx.doi.org/10.1016/j.jmgm.2010.11.008 ER - TY - JOUR T1 - Renal Cancer Risk and Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Plastics AN - 862782843; 14537463 AB - Objective: To investigate whether occupational exposure to polycyclic aromatic hydrocarbons and certain plastic monomers increased renal cell carcinoma (RCC) risk. Methods: Unconditional logistic regression was used to calculate RCC risk in relation to exposure. Results: No association between RCC risk and having ever been occupationally exposed to any polycyclic aromatic hydrocarbons or plastics was observed. Duration of exposure and average exposure also showed no association with risk. Suggestive positive associations between RCC risk and cumulative exposure to styrene (P-trend = 0.02) and acrylonitrile (P-trend = 0.06) were found. Cumulative exposure to petroleum/gasoline engine emissions was inversely associated with risk (P-trend = 0.02). Conclusions: Results indicate a possible association between occupational styrene and acrylonitrile exposure and RCC risk. Additional studies are needed to replicate findings, as this is the first time these associations have been reported and they may be due to chance. JF - Journal of Occupational and Environmental Medicine AU - Karami, S AU - Boffetta, P AU - Brennan, P AU - Stewart, P A AU - Zaridze, D AU - Matveev, V AU - Janout, V AU - Kollarova, H AU - Bencko, V AU - Navratilova, M AU - Szeszenia-Dabrowska, N AU - Mates, D AU - Gromiec, J P AU - Sobotka, R AD - National Cancer Institute, Division of Cancer Epidemiology & Genetics, Occupational and Environmental Epidemiology Branch, 6120 Executive Blvd, EPS 8121, Rockville, MD 20852, USA, karamis@mail.nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 218 EP - 223 VL - 53 IS - 2 SN - 1076-2752, 1076-2752 KW - Toxicology Abstracts; Risk Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - Styrene KW - Polycyclic aromatic hydrocarbons KW - Gasoline KW - acrylonitrile KW - Acrylonitrile KW - Cancer KW - Monomers KW - renal cell carcinoma KW - Petroleum KW - Emissions KW - Kidney KW - polycyclic aromatic hydrocarbons KW - Plastics KW - Occupational exposure KW - P 0000:AIR POLLUTION KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862782843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Renal+Cancer+Risk+and+Occupational+Exposure+to+Polycyclic+Aromatic+Hydrocarbons+and+Plastics&rft.au=Karami%2C+S%3BBoffetta%2C+P%3BBrennan%2C+P%3BStewart%2C+P+A%3BZaridze%2C+D%3BMatveev%2C+V%3BJanout%2C+V%3BKollarova%2C+H%3BBencko%2C+V%3BNavratilova%2C+M%3BSzeszenia-Dabrowska%2C+N%3BMates%2C+D%3BGromiec%2C+J+P%3BSobotka%2C+R&rft.aulast=Karami&rft.aufirst=S&rft.date=2011-02-01&rft.volume=53&rft.issue=2&rft.spage=218&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31820a40a3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2015-06-26 N1 - SubjectsTermNotLitGenreText - Monomers; Styrene; Polycyclic aromatic hydrocarbons; renal cell carcinoma; Gasoline; Petroleum; Kidney; Plastics; Acrylonitrile; Occupational exposure; Emissions; polycyclic aromatic hydrocarbons; acrylonitrile; Cancer DO - http://dx.doi.org/10.1097/JOM.0b013e31820a40a3 ER - TY - JOUR T1 - Pneumatic Actuated Robotic Assistant System for Aortic Valve Replacement Under MRI Guidance AN - 861540554; 14261922 AB - We present a pneumatic actuated robotic assistant system for transapical aortic valve replacement under MRI guidance in a beating heart. This is a minimally invasive procedure that is currently performed manually inside the MRI bore. A robotic assistance system that integrates an interactive real-time MRI system, a robotic arm with a newly developed robotic valve delivery module, as well as user interfaces for the physician to plan the procedure and manipulate the robot, would be advantageous for the procedure. An Innomotion arm with hands-on cooperative interface was used as a device holder. A compact MRI compatible robotic delivery module was developed for delivering both balloon-expandable and self-expanding prostheses. A compact fiducial that can be placed close to the volume of interest and requires a single image plane was used for image-based robot registration. The system provides different user interfaces at various stages of the procedure. We present the development and evaluation of the components and the system in ex-vivo experiments. JF - IEEE Transactions on Biomedical Engineering AU - Li, Ming AU - Kapoor, Ankur AU - Mazilu, Dumitru AU - Horvath, Keith A AD - National Institutes of Health, Bethesda, USA Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 443 EP - 451 PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 USA VL - 58 IS - 2 SN - 0018-9294, 0018-9294 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - robots KW - Aortic valve KW - Energy KW - Magnetic resonance imaging KW - robotics KW - Prosthetics KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/861540554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=IEEE+Transactions+on+Biomedical+Engineering&rft.atitle=Pneumatic+Actuated+Robotic+Assistant+System+for+Aortic+Valve+Replacement+Under+MRI+Guidance&rft.au=Li%2C+Ming%3BKapoor%2C+Ankur%3BMazilu%2C+Dumitru%3BHorvath%2C+Keith+A&rft.aulast=Li&rft.aufirst=Ming&rft.date=2011-02-01&rft.volume=58&rft.issue=2&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Biomedical+Engineering&rft.issn=00189294&rft_id=info:doi/10.1109%2FTBME.2010.2089983 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Heart; robots; Aortic valve; Energy; Magnetic resonance imaging; robotics; Prosthetics DO - http://dx.doi.org/10.1109/TBME.2010.2089983 ER - TY - JOUR T1 - The ubiquitin+proteasome protein degradation pathway as a therapeutic strategy in the treatment of solid tumor malignancies. AN - 861204626; 21355840 AB - A concept that currently steers the development of cancer therapies has been that agents directed against specific proteins that facilitate tumorigenesis or maintain a malignant phenotype will have greater efficacy, less toxicity and a more sustained response relative to traditional cytotoxic chemotherapeutic agents. The clinical success of the targeted agent Imatinib mesylate as an inhibitor of the tyrosine kinase associated with the breakpoint cluster region-Abelson oncogene locus (BCR-ABL) in the treatment of Philadelphia-positive chronic myelogenous leukemia (CML) has served as a paradigm. While intellectually gratifying, the selective targeting of a single driver event by a small molecule, e.g., kinase inhibitor, to dampen a tumor-promoting pathway in the treatment of solid tumors is limited by many factors. Focus can alternatively be placed on targeting fundamental cellular processes that regulate multiple events, e.g., protein degradation, through the Ubiquitin (Ub)+Proteasome System (UPS). The UPS plays a critical role in modulating numerous cellular proteins to regulate cellular processes such as signal transduction, growth, proliferation, differentiation and apoptosis. Clinical success with the proteasome inhibitor bortezomib revolutionized treatment of B-cell lineage malignancies such as Multiple Myeloma (MM). However, many patients harbor primary resistance and do not respond to bortezomib and those that do respond inevitably develop resistance (secondary resistance). The lack of clinical efficacy of proteasome inhibitors in the treatment of solid tumors may be linked mechanistically to the resistance detected during treatment of hematologic malignancies. Potential mechanisms of resistance and means to improve the response to proteasome inhibitors in solid tumors are discussed. JF - Anti-cancer agents in medicinal chemistry AU - Driscoll, James J AU - Minter, Alex AU - Driscoll, Daniel A AU - Burris, Jason K AD - Medical Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. driscollj@mail.nih.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 242 EP - 246 VL - 11 IS - 2 KW - Antineoplastic Agents KW - 0 KW - Proteasome Inhibitors KW - Ubiquitin KW - Index Medicus KW - Drug Delivery Systems KW - Humans KW - Neoplasms -- drug therapy KW - Ubiquitin -- metabolism KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/861204626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-cancer+agents+in+medicinal+chemistry&rft.atitle=The+ubiquitin%2Bproteasome+protein+degradation+pathway+as+a+therapeutic+strategy+in+the+treatment+of+solid+tumor+malignancies.&rft.au=Driscoll%2C+James+J%3BMinter%2C+Alex%3BDriscoll%2C+Daniel+A%3BBurris%2C+Jason+K&rft.aulast=Driscoll&rft.aufirst=James&rft.date=2011-02-01&rft.volume=11&rft.issue=2&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Anti-cancer+agents+in+medicinal+chemistry&rft.issn=1875-5992&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-29 N1 - Date created - 2011-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Magnetic Resonance Studies of Macromolecular Content in Engineered Cartilage Treated with Pulsed Low-Intensity Ultrasound AN - 860389213; 14583378 AB - Noninvasive monitoring of matrix development in tissue-engineered cartilage constructs would permit ongoing assessment with the ability to modify culture conditions during development to optimize tissue characteristics. In this study, chondrocytes seeded in a collagen hydrogel were exposed for 20min/day to pulsed low-intensity ultrasound (PLIUS) at 30 mWcm super(-2) and cultured for up to 5 weeks. Biochemical assays, histology, immuno-histochemistry, Fourier transform infrared spectroscopy, and magnetic resonance imaging (MRI) were performed at weeks 3 and 5 after initiation of growth. The noninvasive MRI measurements were correlated with those from the invasive studies. In particular, MRI transverse relaxation time (T2) and magnetization transfer rate (k sub(m)) correlated with macromolecular content, which was increased by application of PLIUS. This indicates the sensitivity of MR techniques to PLIUS-induced changes in matrix development, and highlights the potential for noninvasive assessment of the efficacy of anabolic interventions for engineered tissue. JF - Tissue Engineering, Part A: Tissue Engineering AU - Irrechukwu, ON AU - Lin, P-C AU - Fritton, K AU - Doty, S AU - Pleshko, N AU - Spencer, R G AD - Magnetic Resonance Imaging and Spectroscopy Section Gerontology Research Center 4D-06 National Institute on Aging National Institutes of Health Baltimore, MD 21224, USA, spencer@helix.nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 407 EP - 415 VL - 17 IS - 3-4 SN - 1937-3341, 1937-3341 KW - Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Macromolecules KW - hydrogels KW - I.R. spectroscopy KW - Cartilage KW - Magnetic resonance imaging KW - Chondrocytes KW - N.M.R. KW - Tissue engineering KW - Ultrasound KW - Collagen KW - T 2030:Cartilage and Cartilage Diseases KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860389213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.atitle=Magnetic+Resonance+Studies+of+Macromolecular+Content+in+Engineered+Cartilage+Treated+with+Pulsed+Low-Intensity+Ultrasound&rft.au=Irrechukwu%2C+ON%3BLin%2C+P-C%3BFritton%2C+K%3BDoty%2C+S%3BPleshko%2C+N%3BSpencer%2C+R+G&rft.aulast=Irrechukwu&rft.aufirst=ON&rft.date=2011-02-01&rft.volume=17&rft.issue=3-4&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.issn=19373341&rft_id=info:doi/10.1089%2Ften.tea.2010.0187 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Macromolecules; hydrogels; I.R. spectroscopy; Cartilage; Magnetic resonance imaging; Chondrocytes; N.M.R.; Tissue engineering; Ultrasound; Collagen DO - http://dx.doi.org/10.1089/ten.tea.2010.0187 ER - TY - JOUR T1 - Safety assessment of allergic contact dermatitis hazards: An analysis supporting reduced animal use for the murine local lymph node assay AN - 860381961; 14364387 AB - The original Organisation for Economic Co-operation and Development Test Guideline 429 (OECD TG 429) for the murine local lymph node assay (LLNA) required five mice/group if mice were processed individually. We used data from 83 LLNA tests (275 treated groups) to determine the impact on the LLNA outcome of reducing the group size from five to four. From DPM measurements, we formed all possible four- and five-mice combinations for the treated and control groups. Stimulation index (SI) values from each four-mice combination were compared with those from five-mice combinations, and agreement (both SI<3 or both SIa[copy343) determined. Average agreement between group sizes was 97.5% for the 275 treated groups. Compared test-by-test, 90% (75/83) of the tests had 100% agreement; agreement was 83% for the remaining eight tests. Disagreement was due primarily to variability in animal responses and closeness of the SI to three (positive response threshold) rather than to group size reduction. We conclude that using four rather than five mice per group would reduce animal use by 20% without adversely impacting LLNA performance. This analysis supported the recent update to OECD TG 429 allowing a minimum of four mice/group when each mouse is processed individually. JF - Regulatory Toxicology and Pharmacology AU - Haseman, Joseph K AU - Strickland, Judy AU - Allen, David AU - Salicru, Eleni AU - Paris, Michael AU - Tice, Raymond R AU - Stokes, William S AD - J.K. Haseman Consulting, Raleigh, NC 27614, USA, stokes@niehs.nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 191 EP - 196 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 59 IS - 1 SN - 0273-2300, 0273-2300 KW - Toxicology Abstracts KW - Group size KW - Data processing KW - Contact dermatitis KW - Economics KW - Local lymph node assay KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860381961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Safety+assessment+of+allergic+contact+dermatitis+hazards%3A+An+analysis+supporting+reduced+animal+use+for+the+murine+local+lymph+node+assay&rft.au=Haseman%2C+Joseph+K%3BStrickland%2C+Judy%3BAllen%2C+David%3BSalicru%2C+Eleni%3BParis%2C+Michael%3BTice%2C+Raymond+R%3BStokes%2C+William+S&rft.aulast=Haseman&rft.aufirst=Joseph&rft.date=2011-02-01&rft.volume=59&rft.issue=1&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2010.10.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2013-09-20 N1 - SubjectsTermNotLitGenreText - Contact dermatitis; Data processing; Group size; Economics; Local lymph node assay DO - http://dx.doi.org/10.1016/j.yrtph.2010.10.004 ER - TY - JOUR T1 - Identifying insertion mutations by whole-genome sequencing AN - 858420493; 14446501 AB - Insertion mutagenesis via mobile genetic element is a common technique for the analysis of gene function in model organisms. Next-generation sequencing offers an attractive approach for localizing the site of insertion, but alignment-based mapping of mobile genetic elements is challenging. A computational method for identifying insertion sites is reported herein. The technique was validated by mapping transposons in both bacterial and nematode species. The approach should be extensible to other systems that employ mobile genetic elements to generate mutations. JF - BioTechniques AU - Smith, HE AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 96 EP - 97 VL - 50 IS - 2 SN - 0736-6205, 0736-6205 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Transposons KW - Insertion KW - Computer applications KW - Mutation KW - Nematoda KW - Gene mapping KW - Mutagenesis KW - Models KW - J 02310:Genetics & Taxonomy KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/858420493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioTechniques&rft.atitle=Identifying+insertion+mutations+by+whole-genome+sequencing&rft.au=Smith%2C+HE&rft.aulast=Smith&rft.aufirst=HE&rft.date=2011-02-01&rft.volume=50&rft.issue=2&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=BioTechniques&rft.issn=07366205&rft_id=info:doi/10.2144%2F000113600 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Transposons; Insertion; Computer applications; Mutation; Models; Mutagenesis; Gene mapping; Nematoda DO - http://dx.doi.org/10.2144/000113600 ER - TY - JOUR T1 - Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells AN - 856789323; 14228816 AB - The nuclear adaptor Ldb1 functions as a core component of multiprotein transcription complexes that regulate differentiation in diverse cell types. In the hematopoietic lineage, Ldb1 forms a complex with the non-DNA-binding adaptor Lmo2 and the transcription factors E2A, Scl and GATA-1 (or GATA-2). Here we demonstrate a critical and continuous requirement for Ldb1 in the maintenance of both fetal and adult mouse hematopoietic stem cells (HSCs). Deletion of Ldb1 in hematopoietic progenitors resulted in the downregulation of many transcripts required for HSC maintenance. Genome-wide profiling by chromatin immunoprecipitation followed by sequencing (ChIP-Seq) identified Ldb1 complex-binding sites at highly conserved regions in the promoters of genes involved in HSC maintenance. Our results identify a central role for Ldb1 in regulating the transcriptional program responsible for the maintenance of HSCs. JF - Nature Immunology AU - Li, LiQi AU - Jothi, Raja AU - Cui, Kairong AU - Lee, Jan Y AU - Cohen, Tsadok AU - Gorivodsky, Marat AU - Tzchori, Itai AU - Zhao, Yangu AU - Hayes, Sandra M AU - Bresnick, Emery H AU - Zhao, Keji AU - Westphal, Heiner AU - Love, Paul E AD - Section on Cellular & Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 129 EP - 136 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 12 IS - 2 SN - 1529-2908, 1529-2908 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Promoters KW - Differentiation KW - Stem cells KW - Chromatin KW - GATA-2 protein KW - Transcription factors KW - Immunoprecipitation KW - Hemopoiesis KW - Fetuses KW - W 30900:Methods KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856789323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Immunology&rft.atitle=Nuclear+adaptor+Ldb1+regulates+a+transcriptional+program+essential+for+the+maintenance+of+hematopoietic+stem+cells&rft.au=Li%2C+LiQi%3BJothi%2C+Raja%3BCui%2C+Kairong%3BLee%2C+Jan+Y%3BCohen%2C+Tsadok%3BGorivodsky%2C+Marat%3BTzchori%2C+Itai%3BZhao%2C+Yangu%3BHayes%2C+Sandra+M%3BBresnick%2C+Emery+H%3BZhao%2C+Keji%3BWestphal%2C+Heiner%3BLove%2C+Paul+E&rft.aulast=Li&rft.aufirst=LiQi&rft.date=2011-02-01&rft.volume=12&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Nature+Immunology&rft.issn=15292908&rft_id=info:doi/10.1038%2Fni.1978 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Differentiation; Promoters; Stem cells; Chromatin; GATA-2 protein; Transcription factors; Immunoprecipitation; Hemopoiesis; Fetuses DO - http://dx.doi.org/10.1038/ni.1978 ER - TY - JOUR T1 - Essential Genetic and Genomic Nursing Competencies for the Oncology Nurse AN - 853208162; 201105574 AB - Objectives To review the opportunities and possibilities for advancing oncology nursing competencies in genetic/genomics through the illustration of case scenarios in clinical care. Data Sources Literature; research reports. Conclusions Oncology nurses have the potential to influence whether or not cutting edge research discoveries are utilized at the bedside. Clinical integration of genetic/genomic information has the potential to optimize health outcomes and lengthen patient lives. Implications for Nursing Practice Oncology nurses need to include genetics/genomics in their practice in order to impact quality patient care today and for the future. [Copyright Elsevier B.V.] JF - Seminars in Oncology Nursing AU - Jenkins, Jean Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 64 EP - 71 PB - Elsevier Ltd, The Netherlands VL - 27 IS - 1 SN - 0749-2081, 0749-2081 KW - Competency KW - genetics KW - genomics KW - oncology nursing education KW - Professional competence KW - Nursing KW - Nurses KW - Oncology KW - Professional practices KW - Patient care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853208162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Oncology+Nursing&rft.atitle=Essential+Genetic+and+Genomic+Nursing+Competencies+for+the+Oncology+Nurse&rft.au=Jenkins%2C+Jean&rft.aulast=Jenkins&rft.aufirst=Jean&rft.date=2011-02-01&rft.volume=27&rft.issue=1&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Oncology+Nursing&rft.issn=07492081&rft_id=info:doi/10.1016%2Fj.soncn.2010.11.008 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-02-16 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Oncology; Nursing; Professional competence; Professional practices; Nurses; Patient care DO - http://dx.doi.org/10.1016/j.soncn.2010.11.008 ER - TY - JOUR T1 - Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier. AN - 848820622; 21048045 AB - Many widespread and persistent organic pollutants, e.g., 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), activate the aryl hydrocarbon receptor (AhR), causing it to translocate to the cell nucleus, where it transactivates target genes. AhR's ability to target the blood-brain barrier is essentially unexplored. We show here that exposing isolated rat brain capillaries to 0.05-0.5 nM TCDD roughly doubled transport activity and protein expression of P-glycoprotein, an ATP-driven drug efflux pump and a critical determinant of drug entry into the CNS. These effects were abolished by actinomycin D or cycloheximide or by the AhR antagonists resveratrol and α-naphthoflavone. Brain capillaries from TCDD-dosed rats (1-5 μg/kg, i.p.) exhibited increased transport activity and protein expression of 3 xenobiotic efflux pumps, P-glycoprotein, multidrug resistance-associated protein 2, and breast cancer resistance polypeptide, as well as expression of Cyp1a1 and Cyp1b1, both AhR target genes. Consistent with increased P-glycoprotein expression in capillaries from TCDD-dosed rats, in situ brain perfusion indicated significantly reduced brain accumulation of verapamil, a P-glycoprotein substrate. These findings suggest a new paradigm for the field of environmental toxicology: toxicants acting through AhR to target xenobiotic efflux transporters at the blood-brain barrier and thus reduce brain accumulation of CNS-acting therapeutic drugs. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Wang, Xueqian AU - Hawkins, Brian T AU - Miller, David S AD - Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 644 EP - 652 VL - 25 IS - 2 KW - Carrier Proteins KW - 0 KW - Polychlorinated Dibenzodioxins KW - Receptors, Aryl Hydrocarbon KW - Xenobiotics KW - 1,2,7,8-tetrachlorodibenzo-p-dioxin KW - 61CLS478M1 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Up-Regulation KW - Male KW - Polychlorinated Dibenzodioxins -- analogs & derivatives KW - Carrier Proteins -- metabolism KW - Carrier Proteins -- genetics KW - Blood-Brain Barrier -- metabolism KW - Adenosine Triphosphate -- metabolism KW - Polychlorinated Dibenzodioxins -- toxicity KW - Receptors, Aryl Hydrocarbon -- metabolism KW - Receptors, Aryl Hydrocarbon -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/848820622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Aryl+hydrocarbon+receptor-mediated+up-regulation+of+ATP-driven+xenobiotic+efflux+transporters+at+the+blood-brain+barrier.&rft.au=Wang%2C+Xueqian%3BHawkins%2C+Brian+T%3BMiller%2C+David+S&rft.aulast=Wang&rft.aufirst=Xueqian&rft.date=2011-02-01&rft.volume=25&rft.issue=2&rft.spage=644&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=1530-6860&rft_id=info:doi/10.1096%2Ffj.10-169227 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-04-04 N1 - Date created - 2011-02-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Pharmacol. 2000 Jan 1;59(1):65-85 [10605936] Mol Pharmacol. 2010 Sep;78(3):376-83 [20547735] J Biol Chem. 2001 Jan 5;276(1):413-20 [11020383] J Biol Chem. 2001 Feb 16;276(7):4819-27 [11096091] Pharm Res. 2001 Jul;18(7):957-63 [11496955] Exp Toxicol Pathol. 2002 Feb;53(6):461-8 [11926288] Toxicol Sci. 2002 Jun;67(2):182-9 [12011477] Mol Cancer Ther. 2002 Apr;1(6):417-25 [12477054] Drug Metab Dispos. 2003 Mar;31(3):259-65 [12584151] Methods Mol Med. 2003;89:209-18 [12958422] Drug Metab Dispos. 2003 Nov;31(11):1279-82 [14570754] J Biol Chem. 2004 May 14;279(20):20582-93 [14978034] Neurotoxicology. 2004 Jun;25(4):605-16 [15183014] Mol Pharmacol. 2004 Sep;66(3):387-94 [15322229] J Biol Chem. 1987 Feb 15;262(5):2116-20 [3029065] Science. 1992 May 22;256(5060):1193-5 [1317062] Mol Pharmacol. 1993 Feb;43(2):200-6 [8381508] J Biol Chem. 1994 Jul 22;269(29):19028-33 [8034660] Am J Physiol. 1995 Jan;268(1 Pt 2):F46-52 [7840247] Mol Cell Biol. 1996 Jan;16(1):430-6 [8524325] Neuroreport. 1995 Dec 15;6(18):2557-60 [8741762] Toxicol Appl Pharmacol. 1996 Oct;140(2):393-403 [8887457] Toxicol Appl Pharmacol. 1998 Jan;148(1):7-13 [9465258] Environ Health Perspect. 1998 Apr;106 Suppl 2:625-33 [9599710] Mol Pharmacol. 1999 Oct;56(4):784-90 [10496962] J Comp Physiol B. 2005 May;175(4):221-30 [15900503] Toxicol In Vitro. 2006 Jun;20(4):426-38 [16198082] Biol Pharm Bull. 2006 May;29(5):1032-5 [16651740] Drug Metab Dispos. 2006 Oct;34(10):1756-63 [16837569] Mol Pharmacol. 2006 Oct;70(4):1212-9 [16837625] Toxicol Sci. 2008 May;103(1):125-36 [18227101] J Cereb Blood Flow Metab. 2008 Jun;28(6):1222-34 [18349876] Curr Med Chem. 2008;15(20):1981-2039 [18691054] J Neurochem. 2008 Dec;107(6):1518-28 [19094056] Pharm Res. 2009 Feb;26(2):480-7 [18841445] J Vet Pharmacol Ther. 2009 Feb;32(1):87-96 [19161460] Adv Drug Deliv Rev. 2009 Jan 31;61(1):26-33 [19111841] Biochem Pharmacol. 2009 Mar 1;77(5):897-909 [19041851] J Pharmacol Exp Ther. 2009 Sep;330(3):956-63 [19491323] Neurobiol Dis. 2010 Jan;37(1):13-25 [19664713] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Oct;27(4):197-211 [19953395] J Neurosci. 2010 Jan 27;30(4):1417-25 [20107068] Pharmacol Rev. 2010 Mar;62(1):1-96 [20103563] Environ Health Perspect. 2010 Apr;118(4):479-84 [20064788] Mol Pharmacol. 2010 May;77(5):715-23 [20101004] Trends Pharmacol Sci. 2010 Jun;31(6):246-54 [20417575] J Pharmacol Exp Ther. 2010 Jul;334(1):147-55 [20421331] J Cereb Blood Flow Metab. 2010 Jul;30(7):1373-83 [20197783] J Psychopharmacol. 2010 Aug;24(8):1237-42 [19942635] Mol Pharmacol. 2000 Dec;58(6):1357-67 [11093774] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1096/fj.10-169227 ER - TY - JOUR T1 - SUMOylation of DLX3 by SUMO1 promotes its transcriptional activity. AN - 847595307; 21268066 AB - Small ubiquitin-like modifiers (SUMO) are post-translational modifiers that regulate target protein activity in diverse ways. The most common group of SUMO substrates is transcription factors, whose transcriptional activity can be altered positively or negatively as a result of SUMOylation. DLX3 is a homeodomain transcription factor involved in placental development, in the differentiation of structures involving epithelial-mesenchymal interactions, such as hair, teeth and nails, and in bone mineralization. We identified two potential SUMOylation sites in the N-terminal domain of DLX3 at positions K83 and K112. Among the six members of the Distal-less family, DLX3 is the only member containing these sites, which are highly conserved among vertebrates. Co-expression experiments demonstrated that DLX3 can be SUMOylated by SUMO1. Site-directed mutagenesis of lysines 83 and 112 to arginines (K83R and K112R) demonstrated that only K112 is involved in SUMOylation. Immunocytochemical analysis determined that SUMOylation does not affect DLX3 translocation to the nucleus and favors perinuclear localization. Moreover, using electrophoresis mobility shift assay (EMSA), we found that DLX3 is still able to bind DNA when SUMOylated. Using luciferase reporter assays, we showed that DLX3(K112R) exhibits a significantly lower transcriptional activity compared to DLX3(WT), suggesting that SUMOylation has a positive effect on DLX3 activity. We identified a new level of regulation in the activity of DLX3 that may play a crucial role in the regulation of hair, teeth, and bone development. Copyright © 2010 Wiley-Liss, Inc. JF - Journal of cellular biochemistry AU - Duverger, Olivier AU - Chen, Susie X AU - Lee, Delia AU - Li, Tianwei AU - Chock, P Boon AU - Morasso, Maria I AD - Developmental Skin Biology Section, NIAMS/NIH, Bethesda, Maryland 20892, USA. Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 445 EP - 452 VL - 112 IS - 2 KW - Distal-less homeobox proteins KW - 0 KW - Homeodomain Proteins KW - SUMO-1 Protein KW - SUMO1 protein, human KW - Transcription Factors KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Protein Binding -- physiology KW - Blotting, Western KW - Humans KW - Electrophoretic Mobility Shift Assay KW - Molecular Sequence Data KW - Transcription, Genetic -- genetics KW - Protein Binding -- genetics KW - Cell Line, Tumor KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Immunohistochemistry KW - Homeodomain Proteins -- genetics KW - Transcription Factors -- metabolism KW - SUMO-1 Protein -- metabolism KW - Transcription Factors -- chemistry KW - Homeodomain Proteins -- metabolism KW - Transcription Factors -- genetics KW - Homeodomain Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/847595307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+biochemistry&rft.atitle=SUMOylation+of+DLX3+by+SUMO1+promotes+its+transcriptional+activity.&rft.au=Duverger%2C+Olivier%3BChen%2C+Susie+X%3BLee%2C+Delia%3BLi%2C+Tianwei%3BChock%2C+P+Boon%3BMorasso%2C+Maria+I&rft.aulast=Duverger&rft.aufirst=Olivier&rft.date=2011-02-01&rft.volume=112&rft.issue=2&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+biochemistry&rft.issn=1097-4644&rft_id=info:doi/10.1002%2Fjcb.22891 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-03 N1 - Date created - 2011-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 1999 Nov 15;18(22):6462-71 [10562558] J Biol Chem. 2009 Jan 23;284(4):2435-47 [19017645] J Cell Sci. 2000 Nov;113 ( Pt 22):4013-23 [11058088] Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14145-50 [11121022] J Biol Chem. 2001 May 25;276(21):18513-8 [11278381] Exp Cell Res. 2001 Nov 15;271(1):57-65 [11697882] Oncogene. 2001 Oct 29;20(49):7243-9 [11704852] Mol Cell Biol. 2002 Jan;22(2):492-504 [11756545] Traffic. 2002 Jun;3(6):381-7 [12010456] Cell Cycle. 2003 Nov-Dec;2(6):528-30 [14504467] Mol Cell Biol. 2004 Oct;24(20):9248-61 [15456894] Mech Dev. 1994 Dec;48(3):199-215 [7893603] Mol Cell Biol. 1997 May;17(5):2920-32 [9111364] Hum Mol Genet. 1998 Mar;7(3):563-9 [9467018] Mol Cell. 1998 Aug;2(2):233-9 [9734360] Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):162-7 [9874789] Cell Cycle. 2004 Dec;3(12):1587-96 [15539951] Birth Defects Res C Embryo Today. 2005 Sep;75(3):163-71 [16187309] Mol Biol Cell. 2005 Nov;16(11):5433-44 [16162816] J Anat. 2005 Nov;207(5):501-61 [16313391] Science. 2006 Sep 22;313(5794):1751 [16990542] Biochem Biophys Res Commun. 2006 Dec 29;351(4):920-6 [17097055] J Biol Chem. 2006 Nov 24;281(47):36221-7 [17012228] J Biol Chem. 2006 Dec 29;281(52):40515-26 [17060321] Mol Cell Biol. 2007 Jan;27(2):622-32 [17101795] Curr Opin Cell Biol. 2007 Jun;19(3):350-5 [17467254] Oncogene. 2007 Aug 30;26(40):5866-76 [17369852] Biochem Soc Trans. 2007 Dec;35(Pt 6):1427-9 [18031238] J Biol Chem. 2008 Jul 18;283(29):20198-208 [18492670] J Biol Chem. 2008 Aug 22;283(34):23235-43 [18579533] Development. 2008 Sep;135(18):3149-59 [18684741] J Biol Chem. 2008 Nov 14;283(46):31991-2002 [18782761] Methods Mol Biol. 2009;497:141-52 [19107415] J Biol Chem. 2000 May 5;275(18):13321-9 [10788439] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jcb.22891 ER - TY - JOUR T1 - GSTM1 null and NAT2 slow acetylation genotypes, smoking intensity and bladder cancer risk: results from the New England bladder cancer study and NAT2 meta-analysis. AN - 847594911; 21037224 AB - Associations between bladder cancer risk and NAT2 and GSTM1 polymorphisms have emerged as some of the most consistent findings in the genetic epidemiology of common metabolic polymorphisms and cancer, but their interaction with tobacco use, intensity and duration remain unclear. In a New England population-based case-control study of urothelial carcinoma, we collected mouthwash samples from 1088 of 1171 cases (92.9%) and 1282 of 1418 controls (91.2%) for genotype analysis of GSTM1, GSTT1 and NAT2 polymorphisms. Odds ratios and 95% confidence intervals of bladder cancer among New England Bladder Cancer Study subjects with one or two inactive GSTM1 alleles (i.e. the 'null' genotype) were 1.26 (0.85-1.88) and 1.54 (1.05-2.25), respectively (P-trend = 0.008), compared with those with two active copies. GSTT1 inactive alleles were not associated with risk. NAT2 slow acetylation status was not associated with risk among never (1.04; 0.71-1.51), former (0.95; 0.75-1.20) or current smokers (1.33; 0.91-1.95); however, a relationship emerged when smoking intensity was evaluated. Among slow acetylators who ever smoked at least 40 cigarettes/day, risk was elevated among ever (1.82; 1.14-2.91, P-interaction = 0.07) and current heavy smokers (3.16; 1.22-8.19, P-interaction = 0.03) compared with rapid acetylators in each category; but was not observed at lower intensities. In contrast, the effect of GSTM1-null genotype was not greater among smokers, regardless of intensity. Meta-analysis of the NAT2 associations with bladder cancer showed a highly significant relationship. Findings from this large USA population-based study provided evidence that the NAT2 slow acetylation genotype interacts with tobacco smoking as a function of exposure intensity. JF - Carcinogenesis AU - Moore, L E AU - Baris, D R AU - Figueroa, J D AU - Garcia-Closas, M AU - Karagas, M R AU - Schwenn, M R AU - Johnson, A T AU - Lubin, J H AU - Hein, D W AU - Dagnall, C L AU - Colt, J S AU - Kida, M AU - Jones, M A AU - Schned, A R AU - Cherala, S S AU - Chanock, S J AU - Cantor, K P AU - Silverman, D T AU - Rothman, N AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA. moorele@mail.nih.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 182 EP - 189 VL - 32 IS - 2 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - NAT2 protein, human KW - Glutathione Transferase KW - EC 2.5.1.18 KW - glutathione S-transferase M1 KW - Index Medicus KW - Genotype KW - Risk KW - Acetylation KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - Urinary Bladder Neoplasms -- etiology KW - Urinary Bladder Neoplasms -- genetics KW - Smoking -- adverse effects KW - Glutathione Transferase -- genetics KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/847594911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=GSTM1+null+and+NAT2+slow+acetylation+genotypes%2C+smoking+intensity+and+bladder+cancer+risk%3A+results+from+the+New+England+bladder+cancer+study+and+NAT2+meta-analysis.&rft.au=Moore%2C+L+E%3BBaris%2C+D+R%3BFigueroa%2C+J+D%3BGarcia-Closas%2C+M%3BKaragas%2C+M+R%3BSchwenn%2C+M+R%3BJohnson%2C+A+T%3BLubin%2C+J+H%3BHein%2C+D+W%3BDagnall%2C+C+L%3BColt%2C+J+S%3BKida%2C+M%3BJones%2C+M+A%3BSchned%2C+A+R%3BCherala%2C+S+S%3BChanock%2C+S+J%3BCantor%2C+K+P%3BSilverman%2C+D+T%3BRothman%2C+N&rft.aulast=Moore&rft.aufirst=L&rft.date=2011-02-01&rft.volume=32&rft.issue=2&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgq223 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-07 N1 - Date created - 2011-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacogenetics. 2000 Jun;10(4):291-2 [10862519] Anticancer Res. 2009 May;29(5):1709-14 [19443391] Stat Med. 2002 Jun 15;21(11):1539-58 [12111919] Cancer Res. 1988 Jul 1;48(13):3849-52 [3378220] Int J Technol Assess Health Care. 1990;6(1):5-30 [2361819] Stat Med. 1994 Jan 30;13(2):153-62 [8122051] Cancer Epidemiol Biomarkers Prev. 1994 Mar;3(2):173-5 [8049640] Cancer Res. 1998 Aug 15;58(16):3603-10 [9721868] Mutat Res. 2005 Mar 7;581(1-2):97-104 [15725609] Lancet. 2005 Aug 20-26;366(9486):649-59 [16112301] Urol Int. 2005;75(4):360-4 [16327307] Stat Med. 2006 Oct 30;25(20):3443-57 [16345038] BMC Cancer. 2006;6:239 [17026750] Cancer Lett. 2007 Jan 8;245(1-2):51-60 [16504378] Int J Cancer. 2007 May 15;120(10):2208-13 [17290402] Int J Epidemiol. 2007 Feb;36(1):23-8 [17510073] Int J Epidemiol. 2007 Feb;36(1):236-41 [17510079] Environ Health. 2007;6:39 [18053222] Carcinogenesis. 2008 Jul;29(7):1386-93 [18544563] Carcinogenesis. 2008 Aug;29(8):1467-74 [18550573] Cancer Genet Cytogenet. 2009 Apr 15;190(2):101-7 [19380028] Anticancer Res. 2009 May;29(5):1631-5 [19443378] Cancer Detect Prev. 2009;32(5-6):416-23 [19303722] J Natl Cancer Inst. 2009 Nov 18;101(22):1553-61 [19917915] Mutat Res. 2001 Oct 1;482(1-2):47-55 [11535248] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgq223 ER - TY - JOUR T1 - Nanotechnology-based cancer therapeutics--promise and challenge--lessons learned through the NCI Alliance for Nanotechnology in Cancer. AN - 847433266; 20814720 AB - The new generation of nanotechnology-based drug formulations is challenging the accepted ways of cancer treatment. Multi-functional nanomaterial constructs have the capability to be delivered directly to the tumor site and eradicate cancer cells selectively, while sparing healthy cells. Tailoring of the nano-construct design can result in enhanced drug efficacy at lower doses as compared to free drug treatment, wider therapeutic window, and lower side effects. Nanoparticle carriers can also address several drug delivery problems which could not be effectively solved in the past and include reduction of multi-drug resistance effects, delivery of siRNA, and penetration of the blood-brain-barrier. Although challenges in understanding toxicity, biodistribution, and paving an effective regulatory path must be met, nanoscale devices carry a formidable promise to change ways cancer is diagnosed and treated. This article summarizes current developments in nanotechnology-based drug delivery and discusses path forward in this field. The discussion is done in context of research and development occurring within the NCI Alliance for Nanotechnology in Cancer program. JF - Pharmaceutical research AU - Farrell, Dorothy AU - Ptak, Krzysztof AU - Panaro, Nicholas J AU - Grodzinski, Piotr AD - Center for Strategic Scientific Initiatives, Office of Director, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 273 EP - 278 VL - 28 IS - 2 KW - Albumin-Bound Paclitaxel KW - 0 KW - Albumins KW - RNA, Small Interfering KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - United States KW - Animals KW - Albumins -- pharmacology KW - National Cancer Institute (U.S.) KW - Humans KW - Blood-Brain Barrier -- metabolism KW - Drug Resistance, Multiple -- drug effects KW - Paclitaxel -- pharmacology KW - Mice KW - RNA, Small Interfering -- therapeutic use KW - Nanomedicine -- trends KW - Neoplasms -- pathology KW - Nanomedicine -- methods KW - Drug Delivery Systems -- methods KW - Neoplasms -- therapy KW - Nanoparticles KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/847433266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmaceutical+research&rft.atitle=Nanotechnology-based+cancer+therapeutics--promise+and+challenge--lessons+learned+through+the+NCI+Alliance+for+Nanotechnology+in+Cancer.&rft.au=Farrell%2C+Dorothy%3BPtak%2C+Krzysztof%3BPanaro%2C+Nicholas+J%3BGrodzinski%2C+Piotr&rft.aulast=Farrell&rft.aufirst=Dorothy&rft.date=2011-02-01&rft.volume=28&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Pharmaceutical+research&rft.issn=1573-904X&rft_id=info:doi/10.1007%2Fs11095-010-0214-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-12 N1 - Date created - 2011-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s11095-010-0214-7 ER - TY - JOUR T1 - Efficacy and safety of dutasteride in patients with spinal and bulbar muscular atrophy: a randomised placebo-controlled trial. AN - 847283320; 21216197 AB - Spinal and bulbar muscular atrophy (SBMA) is caused by polyglutamine expansion in the androgen receptor, which results in ligand-dependent toxicity. Animal models have a neuromuscular deficit that is mitigated by androgen-reducing treatment. We aimed to assess the efficacy and safety of the 5α-reductase inhibitor dutasteride in patients with SBMA, and to identify outcome measures for use in future studies of the disease. We undertook a randomised, double-blind, placebo-controlled, single-site clinical trial in ambulatory, symptomatic men with genetically confirmed SBMA. Participants were assigned by random number table to receive dutasteride (0·5 mg per day) or placebo orally for 24 months. Patients and investigators were masked to treatment allocation. The primary outcome measure was quantitative muscle assessment (QMA). The final efficacy analysis included all patients who were compliant with study treatment at 24 months. This trial was registered with ClinicalTrials.gov, NCT00303446. 50 men were randomly assigned to treatment groups (25 dutasteride, 25 placebo), and 44 were included in the efficacy analysis (21 dutasteride, 23 placebo). At 24 months, the placebo group showed a decrease of 4·5% (-0·30 kg/kg) from baseline in weight-scaled muscle strength as indicated by QMA, and the dutasteride group had an increase in strength of 1·3% (0·14 kg/kg); the difference between groups (5·8%, 95% CI -5·9 to 17·6; p=0·28) was not significant. Prespecified secondary outcome measures of creatine kinase, muscle strength and function, motor nerve conduction, activities of daily living, and erectile function did not show a significant difference between the study groups in change from baseline. Quality of life, as measured by the physical component summary of the Medical Outcomes Study 36-item Short Form version 2, favoured dutasteride (change in score from baseline: placebo, -3·6%, vs dutasteride, 2·1%; p=0·01), whereas the mental component summary favoured placebo (3·3%vs -3·2%; p=0·03). The dutasteride group had fewer patients reporting falls than did the placebo group (9 vs 16; p=0·048); there were no other significant differences in reported adverse events. Our study did not show a significant effect of dutasteride on the progression of muscle weakness in SBMA, although there were secondary indications of both positive and negative effects compared with placebo. A longer trial duration or larger number of patients might be needed to show an effect on disease progression. Performance testing, QMA, and quality of life measures were identified as potentially useful endpoints for future therapeutic trials. Copyright © 2011 Elsevier Ltd. All rights reserved. JF - The Lancet. Neurology AU - Fernández-Rhodes, Lindsay E AU - Kokkinis, Angela D AU - White, Michelle J AU - Watts, Charlotte A AU - Auh, Sungyoung AU - Jeffries, Neal O AU - Shrader, Joseph A AU - Lehky, Tanya J AU - Li, Li AU - Ryder, Jennifer E AU - Levy, Ellen W AU - Solomon, Beth I AU - Harris-Love, Michael O AU - La Pean, Alison AU - Schindler, Alice B AU - Chen, Cheunju AU - Di Prospero, Nicholas A AU - Fischbeck, Kenneth H AD - Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA. Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 140 EP - 147 VL - 10 IS - 2 KW - Azasteroids KW - 0 KW - Dutasteride KW - O0J6XJN02I KW - Index Medicus KW - Fractures, Bone -- physiopathology KW - Double-Blind Method KW - Humans KW - Disease Progression KW - Aged KW - Accidental Falls KW - Adult KW - Treatment Outcome KW - Fractures, Bone -- chemically induced KW - Follow-Up Studies KW - Middle Aged KW - Male KW - Bulbo-Spinal Atrophy, X-Linked -- blood KW - Azasteroids -- therapeutic use KW - Bulbo-Spinal Atrophy, X-Linked -- physiopathology KW - Azasteroids -- adverse effects KW - Bulbo-Spinal Atrophy, X-Linked -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/847283320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Lancet.+Neurology&rft.atitle=Efficacy+and+safety+of+dutasteride+in+patients+with+spinal+and+bulbar+muscular+atrophy%3A+a+randomised+placebo-controlled+trial.&rft.au=Fern%C3%A1ndez-Rhodes%2C+Lindsay+E%3BKokkinis%2C+Angela+D%3BWhite%2C+Michelle+J%3BWatts%2C+Charlotte+A%3BAuh%2C+Sungyoung%3BJeffries%2C+Neal+O%3BShrader%2C+Joseph+A%3BLehky%2C+Tanya+J%3BLi%2C+Li%3BRyder%2C+Jennifer+E%3BLevy%2C+Ellen+W%3BSolomon%2C+Beth+I%3BHarris-Love%2C+Michael+O%3BLa+Pean%2C+Alison%3BSchindler%2C+Alice+B%3BChen%2C+Cheunju%3BDi+Prospero%2C+Nicholas+A%3BFischbeck%2C+Kenneth+H&rft.aulast=Fern%C3%A1ndez-Rhodes&rft.aufirst=Lindsay&rft.date=2011-02-01&rft.volume=10&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=The+Lancet.+Neurology&rft.issn=1474-4465&rft_id=info:doi/10.1016%2FS1474-4422%2810%2970321-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-01 N1 - Date created - 2011-01-24 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00303446; ClinicalTrials.gov N1 - SuppNotes - Cited By: Int J Impot Res. 2002 Aug;14(4):226-44 [12152111] Lancet Neurol. 2010 Sep;9(9):875-84 [20691641] J Clin Endocrinol Metab. 2002 Aug;87(8):3893-901 [12161529] Neurology. 2002 Sep 10;59(5):770-2 [12221177] Neuron. 2002 Aug 29;35(5):843-54 [12372280] Neuron. 2002 Aug 29;35(5):855-64 [12372281] J Neurosci. 2004 May 19;24(20):4778-86 [15152038] Muscle Nerve. 2004 Oct;30(4):463-9 [15316983] Am Rev Respir Dis. 1971 Jan;103(1):57-67 [5540840] Science. 1977 Jul 1;197(4298):77-9 [867053] J Clin Invest. 1993 Aug;92(2):903-10 [7688765] Neurology. 2006 Jun 13;66(11):1711-6 [16769945] Muscle Nerve. 2007 Jan;35(1):36-42 [16969838] Nat Med. 2007 Mar;13(3):348-53 [17334372] Neuropathol Appl Neurobiol. 2007 Apr;33(2):135-51 [17359355] J Urol. 2008 Apr;179(4):1235-42 [18280514] Neurology. 2008 May 20;70(21):1967-71 [18490617] Muscle Nerve. 2008 Aug;38(2):964-71 [18642379] Hum Mol Genet. 2009 Mar 1;18(5):898-910 [19066230] Ann Neurol. 2009 Feb;65(2):140-50 [19259967] BJU Int. 2009 Apr;103(7):919-26 [19239460] Neuron. 2009 Aug 13;63(3):316-28 [19679072] Muscle Nerve. 2009 Nov;40(5):809-14 [19670325] Brain. 2009 Dec;132(Pt 12):3242-51 [19846582] Comment In: Lancet Neurol. 2011 Feb;10(2):113-5 [21216198] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/S1474-4422(10)70321-5 ER - TY - JOUR T1 - In vivo bone formation by progeny of human embryonic stem cells. AN - 847281716; 20590404 AB - The derivation of osteogenic cells from human embryonic stem cells (hESCs) or from induced pluripotent stem cells for bone regeneration would be a welcome alternative to the use of adult stem cells. In an attempt to promote hESC osteogenic differentiation, cells of the HSF-6 line were cultured in differentiating conditions in vitro for prolonged periods of time ranging from 7 to 14.5 weeks, followed by in vivo transplantation into immunocompromised mice in conjunction with hydroxyapatite/tricalcium phosphate ceramic powder. Twelve different medium compositions were tested, along with a number of other variables in culture parameters. In differentiating conditions, HSF-6-derived cells demonstrated an array of diverse phenotypes reminiscent of multiple tissues, but after a few passages, acquired a more uniform, fibroblast-like morphology. Eight to 16 weeks post-transplantation, a group of transplants revealed the formation of histologically proven bone of human origin, including broad areas of multiple intertwining trabeculae, which represents by far the most extensive in vivo bone formation by the hESC-derived cells described to date. Knockout-Dulbecco's modified Eagle's medium-based media with fetal bovine serum, dexamethasone, and ascorbate promoted more frequent bone formation, while media based on α-modified minimum essential medium promoted teratoma formation in 12- to 20-week-old transplants. Transcription levels of pluripotency-related (octamer binding protein 4, Nanog), osteogenesis-related (collagen type I, Runx2, alkaline phosphatase, and bone sialoprotein), and chondrogenesis-related (collagen types II and X, and aggrecan) genes were not predictive of either bone or teratoma formation. The most extensive bone was formed by the strains that, following 4 passages in monolayer conditions, were cultured for 23 to 25 extra days on the surface of hydroxyapatite/tricalcium phosphate particles, suggesting that coculturing of hESC-derived cells with osteoconductive material may increase their osteogenic potential. While none of the conditions tested in this study, and elsewhere, ensured consistent bone formation by hESC-derived cells, our results may elucidate further directions toward the construction of bone on the basis of hESCs or an individual's own induced pluripotent stem cells. JF - Stem cells and development AU - Kuznetsov, Sergei A AU - Cherman, Natasha AU - Robey, Pamela Gehron AD - Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892-4370, USA. skuznets@mail.nih.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 269 EP - 287 VL - 20 IS - 2 KW - Index Medicus KW - Karyotyping KW - Animals KW - Humans KW - Cell Differentiation KW - Mice KW - Mice, Nude KW - Osteoblasts -- cytology KW - Pregnancy KW - Gene Expression Profiling KW - Teratoma -- etiology KW - Immunocompromised Host KW - Stem Cell Transplantation KW - Cell Line KW - Female KW - Embryonic Stem Cells -- cytology KW - Embryonic Stem Cells -- physiology KW - Osteogenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/847281716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+cells+and+development&rft.atitle=In+vivo+bone+formation+by+progeny+of+human+embryonic+stem+cells.&rft.au=Kuznetsov%2C+Sergei+A%3BCherman%2C+Natasha%3BRobey%2C+Pamela+Gehron&rft.aulast=Kuznetsov&rft.aufirst=Sergei&rft.date=2011-02-01&rft.volume=20&rft.issue=2&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Stem+cells+and+development&rft.issn=1557-8534&rft_id=info:doi/10.1089%2Fscd.2009.0501 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-24 N1 - Date created - 2011-01-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Neurobiol. 2008 Aug;38(1):27-65 [18649148] J Orthop Res. 2009 Jul;27(7):916-21 [19137580] Stem Cells Dev. 2009 Sep;18(7):955-68 [19327009] Biomaterials. 2010 Jan;31(2):270-8 [19783038] Biomaterials. 2010 Jan;31(3):404-12 [19819007] Cell Cycle. 2009 Dec;8(23):3822-30 [19887907] J Nippon Med Sch. 2010 Feb;77(1):4-12 [20154452] Med Oral Patol Oral Cir Bucal. 2010 May;15(3):e517-22 [20038898] J Bone Miner Res. 2010 Apr;25(4):796-808 [19821776] Tissue Eng Part A. 2010 Jul;16(7):2331-42 [20196644] J Tissue Eng Regen Med. 2010 Aug;4(6):413-21 [20084623] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):285-90 [16504859] Osteoporos Int. 2006;17(3):319-36 [16341622] Int J Biochem Cell Biol. 2006;38(7):1063-75 [16469522] Stem Cells. 2006 Apr;24(4):835-43 [16253980] J Oral Implantol. 2006;32(3):103-9 [16836173] J Cell Biol. 2006 Jul 17;174(2):169-74 [16831889] Biochemistry (Mosc). 2000 Jan;65(1):117-33 [10702646] Crit Rev Oral Biol Med. 1999;10(1):79-98 [10759428] Dev Biol. 2000 Nov 15;227(2):271-8 [11071754] Biotechnol Bioeng. 2001 Jan 5;72(1):96-107 [11084599] J Bone Miner Res. 2001 May;16(5):857-67 [11341330] Stem Cells. 2001;19(3):180-92 [11359943] J Gene Med. 2001 May-Jun;3(3):240-51 [11437329] Exp Cell Res. 2001 Aug 15;268(2):189-200 [11478845] Gene Ther. 2002 Jul;9(14):915-21 [12085239] J Craniomaxillofac Surg. 2003 Feb;31(1):34-9 [12553924] Science. 2003 May 9;300(5621):913-6 [12738841] Eur J Cell Biol. 2003 Apr;82(4):175-81 [12751903] Surg Neurol. 2003 Jul;60(1):3-4 [12864994] Cloning Stem Cells. 2003;5(2):149-55 [12930627] J Craniofac Surg. 2004 Jan;15(1):34-7 [14704559] Stem Cells. 2006 Aug;24(8):1914-22 [16644919] J Orthop Res. 2006 Aug;24(8):1791-8 [16779832] COPD. 2004 Apr;1(1):71-84 [16997740] Nat Biotechnol. 2004 Jan;22(1):53-4 [14661028] J Biomed Mater Res A. 2004 Mar 15;68(4):747-55 [14986329] Science. 2004 Mar 12;303(5664):1669-74 [14963337] Cell Tissue Kinet. 1987 May;20(3):263-72 [3690622] J Cell Sci. 1991 May;99 ( Pt 1):131-9 [1757497] J Histochem Cytochem. 1994 May;42(5):677-80 [7512588] Histochem Cell Biol. 1996 Dec;106(6):587-92 [8985747] Transplantation. 1997 Apr 27;63(8):1059-69 [9133465] Br J Haematol. 1997 Jun;97(3):561-70 [9207401] J Bone Miner Res. 1997 Sep;12(9):1335-47 [9286749] Science. 1998 Nov 6;282(5391):1145-7 [9804556] J Cell Biochem Suppl. 1998;30-31:73-82 [9893258] Semin Cancer Biol. 1999 Apr;9(2):95-107 [10202131] J Endocrinol. 1999 Sep;162(3):371-9 [10467228] J Mater Sci Mater Med. 2004 Oct;15(10):1123-8 [15516873] Tissue Eng. 2004 Sep-Oct;10(9-10):1518-25 [15588411] Biomaterials. 2005 Jun;26(17):3631-8 [15621253] Tissue Eng. 2002 Dec;8(6):911-20 [12542937] Biomaterials. 2005 Oct;26(29):5879-89 [15913762] J Biomed Mater Res B Appl Biomater. 2005 Jul;74(1):458-67 [15912537] PLoS Med. 2005 Jun;2(6):e161 [15971941] Birth Defects Res C Embryo Today. 2005 Sep;75(3):213-25 [16187316] Lab Invest. 2005 Aug;85(8):962-71 [15924148] Stem Cells. 2005 Oct;23(9):1242-50 [16210408] Orthod Craniofac Res. 2005 Nov;8(4):277-84 [16238608] Bull Exp Biol Med. 2005 Jul;140(1):144-52 [16254641] Biochem Biophys Res Commun. 2006 Feb 10;340(2):403-8 [16389066] Am J Pathol. 2006 Feb;168(2):542-50 [16436668] Stem Cells. 2007 Feb;25(2):425-36 [17053208] Stem Cells Dev. 2007 Feb;16(1):39-52 [17233553] Regen Med. 2007 May;2(3):289-300 [17511565] J Biomed Mater Res A. 2007 Jul;82(1):129-38 [17269144] Stem Cells. 2007 Jul;25(7):1610-7 [17395773] Cell. 2007 Oct 19;131(2):324-36 [17956733] Biomaterials. 2008 Mar;29(8):1043-53 [18023477] J Periodontal Res. 2008 Apr;43(2):127-35 [18302613] Cloning Stem Cells. 2008 Mar;10(1):119-32 [18241129] Methods. 2008 May;45(1):2-9 [18442700] Proc Natl Acad Sci U S A. 2008 May 13;105(19):6840-5 [18467492] J Biosci Bioeng. 2008 Jun;105(6):586-94 [18640597] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/scd.2009.0501 ER - TY - JOUR T1 - Unusual repertoire of vocalizations in adult BTBR T+tf/J mice during three types of social encounters. AN - 846902868; 20618443 AB - BTBR T+tf/J (BTBR) is an inbred mouse strain that displays social deficits and repetitive behaviors analogous to the first and third diagnostic symptoms of autism. We previously reported an unusual pattern of ultrasonic vocalizations in BTBR pups that may represent a behavioral homolog to the second diagnostic symptom of autism, impaired communication. This study investigated the social and vocal repertoire in adult BTBR mice, to evaluate the role of ultrasonic vocalizations in multiple social situations at the adult stage of development. Three different social contexts were considered: male-female, male-male (resident-intruder) and female-female interactions. Behavioral responses and ultrasonic vocalizations were recorded for BTBR and for the highly social control strain C57BL/6J (B6). No episodes of overt fighting or mating were observed during the short durations of the three different experimental encounters. BTBR displayed lower levels of vocalizations and social investigation in all three social contexts as compared with B6. In addition, the correlation analyses between social investigation and ultrasonic vocalization emission rate showed that in B6 mice, the two variables were positively correlated in all the three different social settings, whereas in BTBR mice, the positive correlation was significant only in the male-female interactions. These findings strongly support the value of simultaneously recording two aspects of the mouse social repertoire: social motivation and bioacoustic communication. Moreover, our findings in adults are consistent with previous results in pups, showing an unusual vocal repertoire in BTBR as compared with B6. Genes, Brain and Behavior © 2010 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society. No claim to original US government works. JF - Genes, brain, and behavior AU - Scattoni, M L AU - Ricceri, L AU - Crawley, J N AD - Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD, USA. marialuisa.scattoni@iss.it Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 44 EP - 56 VL - 10 IS - 1 KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Mice KW - Autistic Disorder -- psychology KW - Phenotype KW - Animal Communication KW - Vocalization, Animal -- physiology KW - Ultrasonics KW - Mice, Neurologic Mutants KW - Data Interpretation, Statistical KW - Female KW - Male KW - Sexual Behavior, Animal -- physiology KW - Interpersonal Relations KW - Social Behavior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846902868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes%2C+brain%2C+and+behavior&rft.atitle=Unusual+repertoire+of+vocalizations+in+adult+BTBR+T%2Btf%2FJ+mice+during+three+types+of+social+encounters.&rft.au=Scattoni%2C+M+L%3BRicceri%2C+L%3BCrawley%2C+J+N&rft.aulast=Scattoni&rft.aufirst=M&rft.date=2011-02-01&rft.volume=10&rft.issue=1&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=Genes%2C+brain%2C+and+behavior&rft.issn=1601-183X&rft_id=info:doi/10.1111%2Fj.1601-183X.2010.00623.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-04-25 N1 - Date created - 2011-01-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Am Assoc Lab Anim Sci. 2007 Jan;46(1):28-34 [17203913] Behav Brain Res. 2007 Jan 10;176(1):21-6 [17097158] Pediatr Clin North Am. 2007 Jun;54(3):469-81, vi [17543905] Behav Brain Res. 2007 Sep 4;182(2):223-30 [17336405] Int J Dev Neurosci. 2007 Dec;25(8):515-21 [17980995] Mol Psychiatry. 2008 Jan;13(1):4-26 [17848915] Behav Brain Res. 2008 Mar 5;187(2):371-8 [18005969] Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1710-5 [18227507] Pediatr Rev. 2008 Mar;29(3):86-96 [18310467] Genes Brain Behav. 2008 Mar;7(2):152-63 [17559418] PLoS One. 2008;3(4):e1893 [18382674] PLoS One. 2008;3(8):e3067 [18728777] Behav Brain Res. 2009 Feb 11;197(2):462-5 [18977396] Neurosci Biobehav Rev. 2009 Apr;33(4):508-15 [18771687] Eur J Neurosci. 2009 Apr;29(8):1663-77 [19419429] Biol Lett. 2009 Oct 23;5(5):589-92 [19515648] Neuropsychopharmacology. 2010 Mar;35(4):976-89 [20032969] Biol Psychiatry. 2010 May 1;67(9):864-71 [20034613] Genes Brain Behav. 2011 Feb;10(1):35-43 [20345893] J Autism Dev Disord. 2000 Aug;30(4):345-54 [11039860] J Autism Dev Disord. 2000 Jun;30(3):205-23 [11055457] Behav Neurosci. 2001 Aug;115(4):834-40 [11508722] Nature. 2001 Dec 6;414(6864):631-4 [11740558] J Acoust Soc Am. 2003 Dec;114(6 Pt 1):3412-22 [14714820] Naturwissenschaften. 2004 Aug;91(8):381-5 [15278217] Horm Behav. 2004 Sep;46(3):231-40 [15325224] J Autism Child Schizophr. 1971 Apr-Jun;1(2):119-45 [5172388] Anim Behav. 1972 Feb;20(1):88-100 [4677167] J Comp Physiol Psychol. 1973 Sep;84(3):445-52 [4745813] Behav Neural Biol. 1982 Oct;36(2):197-203 [7183314] Physiol Behav. 1983 Jul;31(1):91-6 [6685321] Physiol Behav. 1983 Sep;31(3):269-72 [6634993] Behav Neural Biol. 1983 Sep;39(1):128-34 [6661142] J Comp Psychol. 1985 Dec;99(4):420-36 [4075780] Behav Neural Biol. 1985 Jul;44(1):139-43 [3834918] Cognition. 1993 Aug;48(2):101-19 [8243028] Psychopharmacology (Berl). 1994 May;114(4):644-50 [7855227] Philos Trans R Soc Lond B Biol Sci. 1994 Oct 29;346(1315):97-104 [7886159] Physiol Behav. 1998 Feb 15;63(4):467-73 [9523885] Dev Psychobiol. 1998 Nov;33(3):249-56 [9810475] Dev Psychobiol. 1999 Apr;34(3):195-204 [10204095] Int J Dev Neurosci. 2005 Apr-May;23(2-3):143-52 [15749241] Nat Neurosci. 2005 Dec;8(12):1637-8 [16306890] PLoS Biol. 2005 Dec;3(12):e386 [16248680] Behav Brain Res. 2007 Jan 10;176(1):4-20 [16971002] PLoS One. 2007;2(4):e351 [17406675] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1601-183X.2010.00623.x ER - TY - JOUR T1 - Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer. AN - 845391996; 21067840 AB - Aberrant activation of the RAS pathway is ubiquitous in human hepatocarcinogenesis, but the molecular mechanisms leading to RAS induction in the absence of RAS mutations remain under-investigated. We defined the role of Ras GTPase activating proteins (GAPs) in the constitutive activity of Ras signaling during human hepatocarcinogenesis. The mutation status of RAS genes and RAS effectors was assessed in a collection of human hepatocellular carcinomas (HCC). Levels of RAS GAPs (RASA1-4, RASAL1, nGAP, SYNGAP1, DAB2IP, and NF1) and the RASAL1 upstream inducer PITX1 were determined by real-time RT-PCR and immunoblotting. The promoter and genomic status of RASAL1, DAB2IP, NF1, and PITX1 were assessed by methylation assays and microsatellite analysis. Effects of RASAL1, DAB2IP, and PITX1 on HCC growth were evaluated by transfection and siRNA analyses of HCC cell lines. In the absence of Ras mutations, downregulation of at least one RAS GAP (RASAL1, DAB2IP, or NF1) was found in all HCC samples. Low levels of DAB2IP and PITX1 were detected mostly in a HCC subclass from patients with poor survival, indicating that these proteins control tumor aggressiveness. In HCC cells, reactivation of RASAL1, DAB2IP, and PITX1 inhibited proliferation and induced apoptosis, whereas their silencing increased proliferation and resistance to apoptosis. Selective suppression of RASAL1, DAB2IP, or NF1 RAS GAPs results in unrestrained activation of Ras signaling in the presence of wild-type RAS in HCC. Published by Elsevier B.V. JF - Journal of hepatology AU - Calvisi, Diego F AU - Ladu, Sara AU - Conner, Elizabeth A AU - Seo, Daekwan AU - Hsieh, Jer-Tsong AU - Factor, Valentina M AU - Thorgeirsson, Snorri S AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4262, USA. Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 311 EP - 319 VL - 54 IS - 2 KW - DAB2IP protein, human KW - 0 KW - Paired Box Transcription Factors KW - homeobox protein PITX1 KW - ras GTPase-Activating Proteins KW - Vascular Endothelial Growth Factor Receptor-2 KW - EC 2.7.10.1 KW - MAP Kinase Kinase Kinase 5 KW - EC 2.7.11.25 KW - MAP3K5 protein, human KW - Phospholipase C gamma KW - EC 3.1.4.3 KW - ras Proteins KW - EC 3.6.5.2 KW - Index Medicus KW - Paired Box Transcription Factors -- antagonists & inhibitors KW - Loss of Heterozygosity KW - Apoptosis KW - DNA Methylation KW - Vascular Endothelial Growth Factor Receptor-2 -- physiology KW - Humans KW - Phospholipase C gamma -- physiology KW - MAP Kinase Kinase Kinase 5 -- physiology KW - Cell Proliferation KW - ras Proteins -- genetics KW - Liver Neoplasms -- pathology KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Carcinoma, Hepatocellular -- etiology KW - Carcinoma, Hepatocellular -- genetics KW - ras GTPase-Activating Proteins -- antagonists & inhibitors KW - Carcinoma, Hepatocellular -- pathology KW - ras GTPase-Activating Proteins -- physiology KW - ras GTPase-Activating Proteins -- genetics KW - Liver Neoplasms -- etiology KW - ras Proteins -- physiology KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/845391996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hepatology&rft.atitle=Inactivation+of+Ras+GTPase-activating+proteins+promotes+unrestrained+activity+of+wild-type+Ras+in+human+liver+cancer.&rft.au=Calvisi%2C+Diego+F%3BLadu%2C+Sara%3BConner%2C+Elizabeth+A%3BSeo%2C+Daekwan%3BHsieh%2C+Jer-Tsong%3BFactor%2C+Valentina+M%3BThorgeirsson%2C+Snorri+S&rft.aulast=Calvisi&rft.aufirst=Diego&rft.date=2011-02-01&rft.volume=54&rft.issue=2&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Journal+of+hepatology&rft.issn=1600-0641&rft_id=info:doi/10.1016%2Fj.jhep.2010.06.036 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-04-25 N1 - Date created - 2011-01-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2002 Apr 12;277(15):12622-31 [11812785] J Natl Cancer Inst. 2007 Dec 19;99(24):1836-44 [18073375] J Clin Invest. 2003 Jun;111(12):1933-43 [12813029] Carcinogenesis. 2004 Apr;25(4):527-33 [14688025] Hepatology. 2004 Sep;40(3):667-76 [15349906] Oncogene. 1989 Jul;4(7):923-8 [2666911] Circ Res. 2008 Apr 11;102(7):840-8 [18292600] Mol Biosyst. 2008 Mar;4(3):213-22 [18437264] Nat Rev Mol Cell Biol. 2008 Jul;9(7):517-31 [18568040] Carcinogenesis. 2008 Oct;29(10):1901-10 [18632756] J Clin Invest. 2008 Dec;118(12):3904-16 [19033661] Gastroenterology. 2009 Jan;136(1):206-16 [18992247] Biochimie. 2009 Mar;91(3):320-8 [19022332] Bioinformatics. 2002 Nov;18(11):1427-31 [12424112] Eur J Clin Invest. 1990 Jun;20(3):225-35 [2114981] Science. 1992 Jun 5;256(5062):1456-9 [1604323] Hepatology. 1997 Nov;26(5):1216-23 [9362365] Cancer Res. 2004 Dec 15;64(24):8919-23 [15604253] Cell. 2005 Jun 17;121(6):849-58 [15960973] Growth Factors. 2005 Jun;23(2):143-9 [16019436] Mol Cancer. 2006;5:36 [16961930] J Hepatol. 2007 Apr;46(4):655-63 [17258345] Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12353-8 [17640920] J Clin Invest. 2007 Sep;117(9):2713-22 [17717605] Comment In: J Hepatol. 2011 Feb;54(2):191-2 [21093951] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jhep.2010.06.036 ER - TY - JOUR T1 - Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver. AN - 843413329; 21135126 AB - Hepatocyte nuclear factor 4α (HNF4α) controls the expression of many critical metabolic pathways, and the Mediator complex occupies a central role in recruiting RNA polymerase II (Pol II) to these gene promoters. An impaired transcriptional HNF4α network in human liver is responsible for many pathological conditions, such as altered drug metabolism, fatty liver, and diabetes. Here, we report that Med25, an associated member of the Mediator complex, is required for the association of HNF4α with Mediator, its several cofactors, and RNA Pol II. Further, increases and decreases in endogenous Med25 levels are reflected in the composition of the transcriptional complex, Pol II recruitment, and the expression of HNF4α-bound target genes. A novel feature of Med25 is that it imparts "selectivity." Med25 affects only a significant subset of HNF4α target genes that selectively regulate drug and lipid metabolism. These results define a role for Med25 and the Mediator complex in the regulation of xenobiotic metabolism and lipid homeostasis. JF - Molecular and cellular biology AU - Rana, Ritu AU - Surapureddi, Sailesh AU - Kam, Waynekid AU - Ferguson, Stephen AU - Goldstein, Joyce A AD - Laboratory of Toxicology and Pharmacology, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 466 EP - 481 VL - 31 IS - 3 KW - Hepatocyte Nuclear Factor 4 KW - 0 KW - MED25 protein, human KW - Mediator Complex KW - Pharmaceutical Preparations KW - Xenobiotics KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - RNA Polymerase II KW - EC 2.7.7.- KW - Index Medicus KW - Pharmaceutical Preparations -- metabolism KW - Hep G2 Cells KW - Down-Regulation -- genetics KW - Gene Silencing KW - Cells, Cultured KW - Humans KW - HEK293 Cells KW - Cytochrome P-450 Enzyme System -- metabolism KW - Transcription, Genetic KW - Hepatocyte Nuclear Factor 4 -- metabolism KW - Protein Binding KW - Signal Transduction KW - RNA Polymerase II -- metabolism KW - Promoter Regions, Genetic KW - Liver -- enzymology KW - Xenobiotics -- metabolism KW - Liver -- metabolism KW - Mediator Complex -- metabolism KW - Lipid Metabolism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/843413329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Med25+is+required+for+RNA+polymerase+II+recruitment+to+specific+promoters%2C+thus+regulating+xenobiotic+and+lipid+metabolism+in+human+liver.&rft.au=Rana%2C+Ritu%3BSurapureddi%2C+Sailesh%3BKam%2C+Waynekid%3BFerguson%2C+Stephen%3BGoldstein%2C+Joyce+A&rft.aulast=Rana&rft.aufirst=Ritu&rft.date=2011-02-01&rft.volume=31&rft.issue=3&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=1098-5549&rft_id=info:doi/10.1128%2FMCB.00847-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-24 N1 - Date created - 2011-01-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Pharmacol. 2008 Sep;74(3):913-23 [18552123] PLoS One. 2009;4(5):e5609 [19440305] FEBS Lett. 2009 Jun 18;583(12):2126-30 [19467232] Curr Drug Metab. 2009 Jul;10(6):567-78 [19702536] Drug Metab Dispos. 2010 Apr;38(4):591-9 [20086032] Mol Cell Biol. 2010 May;30(9):2155-69 [20194623] Trends Biochem Sci. 2010 Jun;35(6):315-22 [20299225] J Pharmacol Exp Ther. 2005 May;313(2):814-22 [15671201] Mol Cell Biol. 2001 Feb;21(4):1393-403 [11158324] Hepatology. 2001 Mar;33(3):668-75 [11230748] Biochem J. 2001 Apr 1;355(Pt 1):71-8 [11256950] Oncogene. 2001 Mar 22;20(12):1455-64 [11313889] Annu Rev Nutr. 2001;21:193-230 [11375435] Cell. 2001 Oct 5;107(1):55-65 [11595185] Science. 2001 Nov 30;294(5548):1866-70 [11729302] Nature. 2001 Dec 13;414(6865):782-7 [11742409] Pharmacol Rev. 2002 Mar;54(1):129-58 [11870262] Mol Endocrinol. 2002 Jul;16(7):1502-10 [12089346] J Biol Chem. 2002 Jul 12;277(28):25257-65 [11994307] Mol Cell Biol. 2002 Aug;22(15):5626-37 [12101254] Biochem Biophys Res Commun. 2002 Aug 16;296(2):281-7 [12163014] Structure. 2002 Sep;10(9):1225-34 [12220494] J Biol Chem. 2002 Oct 11;277(41):37973-6 [12193589] Mol Cell Biol. 2003 Jan;23(1):140-9 [12482968] Nat Med. 2003 Feb;9(2):220-4 [12514743] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4012-7 [12651943] J Biol Chem. 2003 May 9;278(19):17277-83 [12611900] Methods Enzymol. 2003;364:257-84 [14631850] EMBO J. 2003 Dec 15;22(24):6494-504 [14657022] Cell. 2004 Jan 23;116(2):337-50 [14744442] Circulation. 2004 Jan 27;109(3):433-8 [14744958] Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2339-44 [14983011] Mol Cell. 2004 Jun 4;14(5):553-7 [15175151] Mol Cell. 2004 Jun 4;14(5):685-91 [15175163] J Clin Invest. 2004 Jul;114(2):147-52 [15254578] J Biol Chem. 2004 Jul 30;279(31):32345-53 [15166226] Mol Cell Biol. 2004 Sep;24(18):8244-54 [15340084] Am J Med. 1970 Nov;49:617-29 [4924589] Nucleic Acids Res. 1983 Mar 11;11(5):1475-89 [6828386] Biochem J. 1989 May 15;260(1):215-20 [2775184] Genes Dev. 1990 Dec;4(12B):2353-65 [2279702] J Inherit Metab Dis. 1991;14(4):407-20 [1749209] Curr Opin Genet Dev. 1992 Apr;2(2):256-9 [1638120] J Biol Chem. 1996 Oct 11;271(41):25269-76 [8810289] J Biol Chem. 1997 Jan 3;272(1):539-50 [8995295] Nature. 1998 Apr 2;392(6675):512-6 [9548258] J Biol Chem. 1998 Nov 20;273(47):30847-50 [9812974] Mol Cell. 1998 Dec;2(6):851-61 [9885572] J Biol Chem. 1999 Mar 26;274(13):9013-21 [10085149] Mol Cell. 1999 Mar;3(3):361-70 [10198638] Nature. 1999 Apr 29;398(6730):824-8 [10235266] Trends Mol Med. 2004 Nov;10(11):521-4 [15519277] FEBS Lett. 2004 Dec 3;578(1-2):63-8 [15581617] Mol Pharmacol. 2005 Jan;67(1):241-9 [15470081] Lancet. 2005 Apr 16-22;365(9468):1415-28 [15836891] Trends Biochem Sci. 2005 May;30(5):256-63 [15896744] J Pharmacol Exp Ther. 2005 Sep;314(3):1125-33 [15919766] Nat Clin Pract Gastroenterol Hepatol. 2005 Jan;2(1):46-53 [16265100] J Lipid Res. 2006 Jan;47(1):215-27 [16264197] Cell Metab. 2006 Feb;3(2):111-22 [16459312] J Mol Med (Berl). 2006 Apr;84(4):334-44 [16389552] EMBO J. 2007 Aug 8;26(15):3545-57 [17641689] Drug Metab Pharmacokinet. 2007 Aug;22(4):287-98 [17827783] J Proteome Res. 2007 Dec;6(12):4646-55 [17956143] Drug Metab Pharmacokinet. 2008;23(1):2-7 [18305369] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/MCB.00847-10 ER - TY - JOUR T1 - The deceptive nature of UVA tanning versus the modest protective effects of UVB tanning on human skin. AN - 840349427; 20979596 AB - The relationship between human skin pigmentation and protection from ultraviolet (UV) radiation is an important element underlying differences in skin carcinogenesis rates. The association between UV damage and the risk of skin cancer is clear, yet a strategic balance in exposure to UV needs to be met. Dark skin is protected from UV-induced DNA damage significantly more than light skin owing to the constitutively higher pigmentation, but an as yet unresolved and important question is what photoprotective benefit, if any, is afforded by facultative pigmentation (i.e. a tan induced by UV exposure). To address that and to compare the effects of various wavelengths of UV, we repetitively exposed human skin to suberythemal doses of UVA and/or UVB over 2 weeks after which a challenge dose of UVA and UVB was given. Although visual skin pigmentation (tanning) elicited by different UV exposure protocols was similar, the melanin content and UV-protective effects against DNA damage in UVB-tanned skin (but not in UVA-tanned skin) were significantly higher. UVA-induced tans seem to result from the photooxidation of existing melanin and its precursors with some redistribution of pigment granules, while UVB stimulates melanocytes to up-regulate melanin synthesis and increases pigmentation coverage, effects that are synergistically stimulated in UVA and UVB-exposed skin. Thus, UVA tanning contributes essentially no photoprotection, although all types of UV-induced tanning result in DNA and cellular damage, which can eventually lead to photocarcinogenesis. 2010 John Wiley & Sons A/S. This article is a US Government work and is in the public domain in the USA. JF - Pigment cell & melanoma research AU - Miyamura, Yoshinori AU - Coelho, Sergio G AU - Schlenz, Kathrin AU - Batzer, Jan AU - Smuda, Christoph AU - Choi, Wonseon AU - Brenner, Michaela AU - Passeron, Thierry AU - Zhang, Guofeng AU - Kolbe, Ludger AU - Wolber, Rainer AU - Hearing, Vincent J AD - Laboratory of Cell Biology, National Cancer Institute, Bethesda, MD, USA. Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 136 EP - 147 VL - 24 IS - 1 KW - Melanins KW - 0 KW - Protective Agents KW - Pyrimidine Dimers KW - Index Medicus KW - Skin Pigmentation -- radiation effects KW - Pyrimidine Dimers -- metabolism KW - DNA Damage KW - Skin, Artificial KW - Humans KW - Melanins -- metabolism KW - Ultraviolet Rays KW - Skin -- radiation effects KW - Skin -- metabolism KW - Sunbathing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/840349427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pigment+cell+%26+melanoma+research&rft.atitle=The+deceptive+nature+of+UVA+tanning+versus+the+modest+protective+effects+of+UVB+tanning+on+human+skin.&rft.au=Miyamura%2C+Yoshinori%3BCoelho%2C+Sergio+G%3BSchlenz%2C+Kathrin%3BBatzer%2C+Jan%3BSmuda%2C+Christoph%3BChoi%2C+Wonseon%3BBrenner%2C+Michaela%3BPasseron%2C+Thierry%3BZhang%2C+Guofeng%3BKolbe%2C+Ludger%3BWolber%2C+Rainer%3BHearing%2C+Vincent+J&rft.aulast=Miyamura&rft.aufirst=Yoshinori&rft.date=2011-02-01&rft.volume=24&rft.issue=1&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=Pigment+cell+%26+melanoma+research&rft.issn=1755-148X&rft_id=info:doi/10.1111%2Fj.1755-148X.2010.00764.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-04-22 N1 - Date created - 2011-01-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: FASEB J. 2006 Jul;20(9):1486-8 [16793869] Nat New Biol. 1972 Feb 2;235(57):147-9 [4501107] Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13765-70 [16954188] J Investig Dermatol Symp Proc. 1999 Sep;4(1):6-10 [10537000] Curr Opin Cell Biol. 2000 Feb;12(1):57-62 [10679352] J Dermatol Sci. 2000 Mar;23 Suppl 1:S22-6 [10764987] Front Biosci. 2002 Apr 1;7:d765-83 [11897559] Pigment Cell Res. 2002 Oct;15(5):385-90 [12213096] Skin Pharmacol Appl Skin Physiol. 2002 Sep-Oct;15(5):316-20 [12239425] Photodermatol Photoimmunol Photomed. 2002 Oct;18(5):223-7 [12390662] FASEB J. 2003 Jun;17(9):1177-9 [12692083] Dermatol Clin. 2003 Oct;21(4):725-32, x [14717413] Photodermatol Photoimmunol Photomed. 2004 Feb;20(1):27-32 [14738530] Photochem Photobiol Sci. 2004 Mar;3(3):257-62 [14993941] J Invest Dermatol. 2004 Feb;122(2):503-9 [15009737] Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4954-9 [15041750] Pigment Cell Res. 2004 Oct;17(5):498-505 [15357836] Cancer Res. 2004 Sep 15;64(18):6372-6 [15374941] Yale J Biol Med. 1973 Dec;46(5):411-26 [4779128] Arch Dermatol. 1982 Jul;118(7):483-6 [7092273] Photochem Photobiol. 1984 Oct;40(4):485-94 [6505037] J Invest Dermatol. 1985 Oct;85(4):362-4 [3840189] J Invest Dermatol. 1987 Jan;88(1):83-7 [3794392] Biochem Biophys Res Commun. 1987 Jan 15;142(1):265-74 [3101689] J Int Med Res. 1990;18 Suppl 3:8C-17C [2227089] Exp Cell Res. 1991 Jul;195(1):269-73 [1676000] Cell Motil Cytoskeleton. 1992;22(4):296-306 [1381290] N Engl J Med. 1992 Dec 3;327(23):1649-62 [1435901] Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6666-70 [8341684] J Am Acad Dermatol. 1995 Jan;32(1):53-62 [7822517] J Photochem Photobiol B. 1997 Aug;40(1):29-47 [9301042] J Am Acad Dermatol. 1998 Jan;38(1):89-98 [9448211] J Invest Dermatol. 1998 May;110(5):806-10 [9579550] J Investig Dermatol Symp Proc. 1996 Apr;1(2):136-42 [9627707] Biochim Biophys Acta. 1998 Sep 16;1425(1):27-35 [9813229] N Engl J Med. 1999 Apr 29;340(17):1341-8 [10219070] J Biol Chem. 1999 May 28;274(22):15345-9 [10336420] Mutat Res. 2005 Apr 1;571(1-2):121-32 [15748643] Acta Derm Venereol. 2005;85(1):24-6 [15848986] J Invest Dermatol. 2005 Jun;124(6):1326-32 [15955111] Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10058-63 [16009942] J Photochem Photobiol B. 2006 Mar 1;82(3):194-8 [16388960] Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4111-5 [16537493] J Proteome Res. 2006 Nov;5(11):3135-44 [17081065] Pigment Cell Res. 2007 Feb;20(1):2-13 [17250543] J Invest Dermatol. 2008 Jan;128(1):162-74 [17687388] Photodermatol Photoimmunol Photomed. 2008 Apr;24(2):76-82 [18353087] Photochem Photobiol. 2008 May-Jun;84(3):539-49 [18435612] Pigment Cell Melanoma Res. 2008 Aug;21(4):487-91 [18627527] Pigment Cell Melanoma Res. 2008 Oct;21(5):509-16 [18821855] Pigment Cell Melanoma Res. 2008 Oct;21(5):517-9 [18821856] Pigment Cell Melanoma Res. 2008 Oct;21(5):520-4 [18821857] Br J Dermatol. 2008 Sep;159(4):921-30 [18616777] Pigment Cell Melanoma Res. 2009 Apr;22(2):238-41 [19226313] Clin Pediatr (Phila). 2009 Jul;48(6):614-22 [19286623] Photochem Photobiol. 2009 Jul-Aug;85(4):1032-7 [19320841] Pigment Cell Melanoma Res. 2010 Feb;23(1):57-63 [19968819] Exp Dermatol. 2010 Feb;19(2):81-8 [20067521] Pigment Cell Melanoma Res. 2010 Apr;23(2):171-86 [20128873] J Invest Dermatol. 2010 Jun;130(6):1685-96 [20147966] Proc Natl Acad Sci U S A. 2010 May 18;107(20):9329-34 [20439744] Pigment Cell Melanoma Res. 2010 Jun;23(3):314-37 [20230482] Cancer Epidemiol Biomarkers Prev. 2010 Jun;19(6):1557-68 [20507845] Neoplasma. 2006;53(4):328-32 [16830061] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1755-148X.2010.00764.x ER - TY - JOUR T1 - Amelioration of cisplatin-induced nephrotoxicity in mice by oral administration of diphenylmethyl selenocyanate. AN - 835118979; 20942565 AB - Cisplatin is one of the most potent and active cytotoxic drug in the treatment of cancer. However, side-effects in normal tissues and organs, notably nephrotoxicity in the kidneys, limit the promising efficacy of cisplatin. The present study was designed to ascertain the possible in vivo protective potential of a synthetic organoselenium compound diphenylmethyl selenocyanate (3 mg/kg.b.w.) against the nephrotoxic damage induced by cisplatin (5 mg/kg.b.w. for 5 days) in Swiss albino mice. Treatment with diphenylmethyl selenocyanate markedly reduced cisplatin-induced lipid peroxidation, serum creatinine and blood urea nitrogen levels. Renal antioxidant defense systems, such as glutathione-S-transferase, glutathione peroxidase, superoxide dismutase, catalase, activities and reduced glutathione level, depleted by cisplatin therapy, were restored to normal by the selenium compound. The selenium compound also reduced renal tubular epithelial cell damage, nitric oxide levels and expression of COX-2, and iNOS in kidneys injured by cisplatin. These results demonstrate the protective effect of diphenylmethyl selenocyanate against cisplatin-induced nephrotoxicity in mice. JF - Free radical research AU - Chakraborty, Pramita AU - Roy, Somnath Singha AU - Sk, Ugir Hossain AU - Bhattacharya, Sudin AD - Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700026, West Bengal, India. Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 177 EP - 187 VL - 45 IS - 2 KW - Organoselenium Compounds KW - 0 KW - diphenylmethyl selenocyanate KW - Creatinine KW - AYI8EX34EU KW - Catalase KW - EC 1.11.1.6 KW - Glutathione Peroxidase KW - EC 1.11.1.9 KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - Nos2 protein, mouse KW - Ptgs2 protein, mouse KW - EC 1.14.99.- KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Glutathione KW - GAN16C9B8O KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Animals KW - Kidney Neoplasms -- drug therapy KW - Kidney Neoplasms -- pathology KW - Gene Expression KW - Kidney -- enzymology KW - Superoxide Dismutase -- metabolism KW - Glutathione -- blood KW - Creatinine -- blood KW - Glutathione Peroxidase -- metabolism KW - Glutathione Transferase -- blood KW - Kidney Neoplasms -- complications KW - Cyclooxygenase 2 -- metabolism KW - Male KW - Administration, Oral KW - Kidney -- pathology KW - Cyclooxygenase 2 -- genetics KW - Superoxide Dismutase -- blood KW - Glutathione -- metabolism KW - Glutathione Transferase -- metabolism KW - Glutathione Peroxidase -- blood KW - Lipid Peroxidation -- drug effects KW - Mice KW - Catalase -- metabolism KW - Kidney Neoplasms -- metabolism KW - Nitric Oxide Synthase Type II -- metabolism KW - Nitric Oxide Synthase Type II -- genetics KW - Catalase -- blood KW - Immunohistochemistry KW - Organoselenium Compounds -- administration & dosage KW - Organoselenium Compounds -- therapeutic use KW - Oxidative Stress -- drug effects KW - Cisplatin -- pharmacology KW - Cisplatin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/835118979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+research&rft.atitle=Amelioration+of+cisplatin-induced+nephrotoxicity+in+mice+by+oral+administration+of+diphenylmethyl+selenocyanate.&rft.au=Chakraborty%2C+Pramita%3BRoy%2C+Somnath+Singha%3BSk%2C+Ugir+Hossain%3BBhattacharya%2C+Sudin&rft.aulast=Chakraborty&rft.aufirst=Pramita&rft.date=2011-02-01&rft.volume=45&rft.issue=2&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Free+radical+research&rft.issn=1029-2470&rft_id=info:doi/10.3109%2F10715762.2010.521155 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-01 N1 - Date created - 2011-01-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/10715762.2010.521155 ER - TY - JOUR T1 - Verapamil protects dopaminergic neuron damage through a novel anti-inflammatory mechanism by inhibition of microglial activation. AN - 822364371; 20950631 AB - Verapamil has been shown to be neuroprotective in several acute neurotoxicity models due to blockade of calcium entry into neurons. However, the potential use of verapamil to treat chronic neurodegenerative diseases has not been reported. Using rat primary mesencephalic neuron/glia cultures, we report that verapamil significantly inhibited LPS-induced dopaminergic neurotoxicity in both pre- and post-treatment experiments. Reconstituted culture studies revealed that the presence of microglia was essential in verapamil-elicited neuroprotection. Mechanistic studies showed that decreased production of inflammatory mediators from LPS-stimulated microglia underlay neuroprotective property of verapamil. Further studies demonstrated that microglial NADPH oxidase (PHOX), the key superoxide-producing enzyme, but not calcium channel in neurons, is the site of action for the neuroprotective effect of verapamil. This conclusion was supported by the following two observations: 1) Verapamil failed to show protective effect on LPS-induced dopaminergic neurotoxicity in PHOX-deficient (deficient in the catalytic subunit of gp91(phox)) neuron/glia cultures; 2) Ligand binding studies showed that the binding of [(3)H]Verapamil onto gp91(phox) transfected COS7 cell membranes was higher than the non-transfected control. The calcium channel-independent neuroprotective property of verapamil was further supported by the finding that R(+)-verapamil, a less active form in blocking calcium channel, showed the same potency in neuroprotection, inhibition of pro-inflammatory factors production and binding capacity to gp91(phox) membranes as R(-)-verapamil, the active isomer of calcium channel blocker. In conclusion, our results demonstrate a new indication of verapamil-mediated neuroprotection through a calcium channel-independent pathway and provide a valuable avenue for the development of therapy for inflammation-related neurodegenerative diseases. Published by Elsevier Ltd. JF - Neuropharmacology AU - Liu, Yuxin AU - Lo, Yi-Ching AU - Qian, Li AU - Crews, Fulton Tim AU - Wilson, Belinda AU - Chen, Hui-Ling AU - Wu, Hung-Ming AU - Chen, Shih-Heng AU - Wei, Ke AU - Lu, Ru-Band AU - Ali, Syed AU - Hong, Jau-Shyong AD - Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. PY - 2011 SP - 373 EP - 380 VL - 60 IS - 2-3 KW - Anti-Inflammatory Agents KW - 0 KW - Lipopolysaccharides KW - Neuroprotective Agents KW - Verapamil KW - CJ0O37KU29 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - COS Cells KW - Inflammation -- drug therapy KW - Mice KW - Mice, Transgenic KW - Pregnancy KW - Rats KW - Rats, Inbred F344 KW - Cells, Cultured KW - Cercopithecus aethiops KW - Mice, Inbred C57BL KW - Lipopolysaccharides -- toxicity KW - Inflammation -- metabolism KW - Female KW - Male KW - Inflammation -- pathology KW - Neurons -- metabolism KW - Neurons -- drug effects KW - Anti-Inflammatory Agents -- therapeutic use KW - Dopamine -- metabolism KW - Verapamil -- pharmacology KW - Neuroprotective Agents -- therapeutic use KW - Microglia -- pathology KW - Microglia -- drug effects KW - Neuroprotective Agents -- pharmacology KW - Neurons -- pathology KW - Microglia -- metabolism KW - Anti-Inflammatory Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822364371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Verapamil+protects+dopaminergic+neuron+damage+through+a+novel+anti-inflammatory+mechanism+by+inhibition+of+microglial+activation.&rft.au=Liu%2C+Yuxin%3BLo%2C+Yi-Ching%3BQian%2C+Li%3BCrews%2C+Fulton+Tim%3BWilson%2C+Belinda%3BChen%2C+Hui-Ling%3BWu%2C+Hung-Ming%3BChen%2C+Shih-Heng%3BWei%2C+Ke%3BLu%2C+Ru-Band%3BAli%2C+Syed%3BHong%2C+Jau-Shyong&rft.aulast=Liu&rft.aufirst=Yuxin&rft.date=2011-02-01&rft.volume=60&rft.issue=2-3&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=1873-7064&rft_id=info:doi/10.1016%2Fj.neuropharm.2010.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-22 N1 - Date created - 2011-01-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem J. 1997 May 15;324 ( Pt 1):201-7 [9164857] Biochem J. 1997 Nov 1;327 ( Pt 3):819-23 [9581561] Shock. 1997 Sep;8(3):170-8 [9377163] J Leukoc Biol. 1998 Nov;64(5):615-21 [9823766] Eur J Pharmacol. 1998 Dec 11;363(1):1-15 [9877076] Am J Physiol. 1999 Aug;277(2 Pt 1):G351-60 [10444449] Neurosci Res. 2005 Aug;52(4):347-56 [15896866] Exp Brain Res. 2006 Apr;170(3):368-75 [16328269] FASEB J. 2000 Mar;14(3):476-84 [10698962] J Pharmacol Exp Ther. 2000 May;293(2):607-17 [10773035] Neuroscience. 2000;97(4):749-56 [10842020] J Neurochem. 2002 Jun;81(6):1285-97 [12068076] Biochem Biophys Res Commun. 2006 Jun 2;344(2):571-80 [16630555] Inflamm Res. 2006 Mar;55(3):108-13 [16673153] FASEB J. 2006 May;20(7):906-15 [16675848] Heart Vessels. 2006 May;21(3):162-8 [16715191] Eur J Clin Pharmacol. 2006 Aug;62(8):613-9 [16823584] J Neurosci. 2007 May 9;27(19):5249-59 [17494711] Am J Hypertens. 2008 Jan;21(1):78-84 [18091748] Neuropharmacology. 2008 Sep;55(3):363-89 [18308347] Ann Neurol. 2010 May;67(5):600-6 [20437557] Physiol Genomics. 2002 Oct 29;11(2):45-52 [12388792] J Biol Chem. 2004 Jan 9;279(2):1415-21 [14578353] Beijing Da Xue Xue Bao. 2004 Aug 18;36(4):361-5 [15303126] Curr Drug Targets. 2004 Oct;5(7):603-18 [15473250] Circ Res. 1983 Feb;52(2 Pt 2):I3-16 [6339106] Am Heart J. 1985 Feb;109(2):210-7 [3966339] Circ Shock. 1985;16(3):307-16 [3902273] Biochem Pharmacol. 1986 Oct 15;35(20):3465-71 [3021172] J Pharmacol Exp Ther. 1987 Sep;242(3):1090-7 [3656109] J Hepatol. 1991 Mar;12(2):251-5 [2051005] J Cardiovasc Pharmacol. 1991;18 Suppl 10:S1-6 [1724996] Infect Immun. 1996 Jul;64(7):2812-6 [8698514] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuropharm.2010.10.002 ER - TY - JOUR T1 - Injury-induced neurogenesis: consideration of resident microglia as supportive of neural progenitor cells. AN - 821973698; 20524106 AB - The induction of neurogenesis in the adult subgranular zone (SGZ) by injury is often accompanied by changes in the extracellular environment that can have significant impacts on neural progenitor cells (NPCs). We examined the induction of neurogenesis in the SGZ at 72 h following an injection of the hippocampal toxicant, trimethyltin (TMT; 2 mg/kg, ip) inducing apoptosis in dentate granule neurons. BrdU+ incorporation during the active period of neuronal death indicated NPC proliferation and migration of newly generated cells into the granule cell layer (GCL). BrdU+ cells were transiently in contact with process bearing microglia within the inner SGZ layer. Contact with GFAP+ astrocyte processes occurred once cells were within the GCL. A small percentage of the BrdU+ cells within the SGZ region showed immunoreactivity for tumor necrosis factor (TNF) p75 receptor (TNFp75R). In mice deficient for TNFp75R, TMT injection produced an equivalent level of dentate granule cell death however; BrdU+ cells were localized at the SGZ as compared to the presence of cells within the GCL in the WT mice dosed with TMT. These data suggest that cells generated by NPCs in the SGZ induced with a focal lesion to the dentate granule neurons of adolescent mice maintain the capacity to utilize the neuroinflammation and microglia responses within their environment for migration into the GCL. JF - Neurotoxicity research AU - McPherson, Christopher A AU - Kraft, Andrew D AU - Harry, G Jean AD - Neurotoxicology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Science, National Institutes of Health, MD C1-04, P.O. Box 12233, Research Triangle Park, NC 27709, USA. Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 341 EP - 352 VL - 19 IS - 2 KW - Index Medicus KW - Microscopy, Fluorescence KW - Animals KW - Cell Movement -- physiology KW - Apoptosis -- physiology KW - Mice, Inbred C57BL KW - Mice KW - Mice, Transgenic KW - Male KW - Mice, Knockout KW - Neurogenesis -- physiology KW - Microglia -- physiology KW - Hippocampus -- physiology KW - Neurons -- physiology KW - Hippocampus -- injuries KW - Stem Cells -- pathology KW - Stem Cells -- physiology KW - Hippocampus -- pathology KW - Microglia -- pathology KW - Neurons -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821973698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicity+research&rft.atitle=Injury-induced+neurogenesis%3A+consideration+of+resident+microglia+as+supportive+of+neural+progenitor+cells.&rft.au=McPherson%2C+Christopher+A%3BKraft%2C+Andrew+D%3BHarry%2C+G+Jean&rft.aulast=McPherson&rft.aufirst=Christopher&rft.date=2011-02-01&rft.volume=19&rft.issue=2&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Neurotoxicity+research&rft.issn=1476-3524&rft_id=info:doi/10.1007%2Fs12640-010-9199-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-09 N1 - Date created - 2010-12-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Brain Res. 2002 Aug 23;947(1):41-9 [12144851] Nat Med. 2002 Sep;8(9):955-62 [12161748] Neurotoxicology. 2003 Jun;24(3):343-56 [12782100] Cytokine. 2003 May;22(3-4):101-6 [12849709] Cell. 2003 Jul 25;114(2):181-90 [12887920] Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13632-7 [14581618] Cell Signal. 2004 Feb;16(2):139-44 [14636884] Science. 2003 Dec 5;302(5651):1760-5 [14615545] Mol Cell Neurosci. 2003 Nov;24(3):623-31 [14664813] Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15983-8 [14668448] Neurotox Res. 2003;5(5):339-54 [14715453] Neurotox Res. 2004;5(8):623-7 [15111239] J Neurochem. 2004 Jul;90(1):89-101 [15198670] Trends Neurosci. 2004 Aug;27(8):447-52 [15271491] J Biol Response Mod. 1989 Dec;8(6):644-55 [2600604] J Biol Chem. 1997 Feb 7;272(6):3550-3 [9013604] J Neurotrauma. 1997 Apr;14(4):179-89 [9151767] Trends Neurosci. 1997 Aug;20(8):357-65 [9246730] Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10432-7 [9294228] J Neurosci. 2002 Apr 15;22(8):3025-32 [11943805] Nature. 2002 Feb 28;415(6875):1030-4 [11875571] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4710-5 [11296300] J Neurosci Res. 2000 Oct 1;62(1):146-55 [11002296] Brain Res. 1998 Apr 20;790(1-2):52-9 [9593820] Neurotoxicology. 2009 Sep;30(5):785-93 [19596372] J Neurochem. 1998 Oct;71(4):1577-87 [9751191] J Comp Neurol. 1999 Apr 19;406(4):449-60 [10205022] Neuroscience. 2004;129(3):593-601 [15541881] J Neurochem. 2005 Apr;93(1):206-20 [15773920] Brain Res Bull. 2005 May 30;65(6):471-7 [15862918] J Neurosci Res. 2005 Jun 15;80(6):789-97 [15884015] Brain Res. 2005 Aug 30;1054(2):152-8 [16054598] J Neurosci Res. 2005 Dec 1;82(5):609-21 [16273549] J Leukoc Biol. 2005 Dec;78(6):1233-41 [16314440] Mol Cell Neurosci. 2006 Jan;31(1):149-60 [16297637] Eur J Neurosci. 2006 Jan;23(1):83-93 [16420418] Stem Cells Dev. 2006 Jun;15(3):407-21 [16846377] J Neurosci. 2006 Sep 20;26(38):9703-12 [16988041] BMC Neurosci. 2006;7:64 [16987412] Nat Neurosci. 2007 Mar;10(3):355-62 [17277773] J Neurotrauma. 2007 Jul;24(7):1132-46 [17610353] Glia. 2008 Mar;56(4):412-25 [18186084] Brain Res. 2008 Feb 15;1194:8-20 [18191113] Glia. 2008 May;56(7):791-800 [18338791] Epilepsia. 2008 Jun;49 Suppl 5:19-25 [18522597] J Neurochem. 2008 Jul;106(1):281-98 [18373618] J Neurosci. 2008 Nov 26;28(48):12901-12 [19036984] Glia. 2009 Jun;57(8):835-49 [19053043] Neurotox Res. 2009 Oct;16(3):280-92 [19526277] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s12640-010-9199-6 ER - TY - JOUR T1 - Phase 1 trial and pharmacokinetic study of the farnesyl transferase inhibitor tipifarnib in children and adolescents with refractory leukemias: a report from the Children's Oncology Group. AN - 818401567; 20860038 AB - The objectives of this trial were to define the toxicity profile, dose, pharmacokinetics, and pharmacodynamics of the farnesyl transferase (FTase) inhibitor, tipifarnib, in children and adolescents with hematological malignancies. Tipifarnib was administered twice daily for 21 days, repeated every 28 days starting at a dose of 300 mg/m(2) /dose. Pharmacokinetic sampling was performed for 36 hr after the first dose and leukemic blasts were collected pre-treatment and at steady state for determination of FTase activity. Of 29 patients enrolled, 18 were fully evaluable for toxicity, and 23 for response; 26 had pharmacokinetic and pharmacodynamic sampling. The recommended dose is 300 mg/m(2) /dose and toxicities included skin rash, mucositis, nausea, vomiting, and diarrhea. Neurotoxicity, which was dose-limiting in adults at doses exceeding 600 mg/dose, was infrequent and mild. The plasma pharmacokinetics of tipifarnib were highly variable but comparable to adults with acute leukemia and children with solid tumors. The median apparent clearance of tipifarnib was 630 ml/min/m(2) and the median half-life was 4.7 hr. At steady state on 300 mg/m(2) /dose, FTase activity was inhibited by 82% in leukemic blasts. No objective responses were observed. Oral tipifarnib is well tolerated in children with leukemia on a twice daily for 2 days schedule at 300 mg/m(2) /dose. Copyright © 2010 Wiley-Liss, Inc. JF - Pediatric blood & cancer AU - Widemann, Brigitte C AU - Arceci, Robert J AU - Jayaprakash, Nalini AU - Fox, Elizabeth AU - Zannikos, Peter AU - Goodspeed, Wendy AU - Goodwin, Anne AU - Wright, John J AU - Blaney, Susan M AU - Adamson, Peter C AU - Balis, Frank M AD - Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA. widemanb@mail.nih.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 226 EP - 233 VL - 56 IS - 2 KW - Antineoplastic Agents KW - 0 KW - Quinolones KW - Farnesyltranstransferase KW - EC 2.5.1.29 KW - tipifarnib KW - MAT637500A KW - Index Medicus KW - Infant KW - Half-Life KW - Humans KW - Child KW - Maximum Tolerated Dose KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Leukemia -- drug therapy KW - Quinolones -- therapeutic use KW - Neoplasm Recurrence, Local -- drug therapy KW - Quinolones -- pharmacokinetics KW - Farnesyltranstransferase -- antagonists & inhibitors KW - Antineoplastic Agents -- pharmacokinetics KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/818401567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+blood+%26+cancer&rft.atitle=Phase+1+trial+and+pharmacokinetic+study+of+the+farnesyl+transferase+inhibitor+tipifarnib+in+children+and+adolescents+with+refractory+leukemias%3A+a+report+from+the+Children%27s+Oncology+Group.&rft.au=Widemann%2C+Brigitte+C%3BArceci%2C+Robert+J%3BJayaprakash%2C+Nalini%3BFox%2C+Elizabeth%3BZannikos%2C+Peter%3BGoodspeed%2C+Wendy%3BGoodwin%2C+Anne%3BWright%2C+John+J%3BBlaney%2C+Susan+M%3BAdamson%2C+Peter+C%3BBalis%2C+Frank+M&rft.aulast=Widemann&rft.aufirst=Brigitte&rft.date=2011-02-01&rft.volume=56&rft.issue=2&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Pediatric+blood+%26+cancer&rft.issn=1545-5017&rft_id=info:doi/10.1002%2Fpbc.22775 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-21 N1 - Date created - 2010-12-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Invest New Drugs. 1999;17(3):241-58 [10665477] Anticancer Drugs. 2001 Mar;12(3):163-84 [11290863] Anticancer Drugs. 2001 Mar;12(3):193-7 [11290865] Blood. 2001 Jun 1;97(11):3361-9 [11369625] J Clin Oncol. 2002 Jun 1;20(11):2726-35 [12039935] J Clin Oncol. 2003 Apr 1;21(7):1301-6 [12663718] Curr Opin Drug Discov Devel. 2004 Jul;7(4):478-86 [15338957] J Clin Oncol. 2004 Dec 1;22(23):4816-22 [15570084] Cancer Cell. 2005 Apr;7(4):297-300 [15837619] J Clin Oncol. 2006 Jan 20;24(3):507-16 [16421428] Future Oncol. 2005 Dec;1(6):719-31 [16556050] Br J Clin Pharmacol. 2006 Jul;62(1):81-96 [16842381] Blood. 2007 Feb 15;109(4):1387-94 [17082323] Blood. 2007 May 15;109(10):4158-63 [17264294] Blood. 2007 Jun 15;109(12):5151-6 [17351110] Oncologist. 2008 Jun;13(6):679-89 [18586923] Leukemia. 2008 Jul;22(7):1335-42 [18548091] Blood. 2009 Aug 6;114(6):1166-73 [19470696] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/pbc.22775 ER - TY - JOUR T1 - Radiation Metabolomics. 4. UPLC-ESI-QTOFMS-Based Metabolomics for Urinary Biomarker Discovery in Gamma-Irradiated Rats AN - 1758238408; 14658129 AB - Radiation metabolomics has aided in the identification of a number of biomarkers in cells and mice by ultra-performance liquid chromatography-coupled time-of-flight mass spectrometry (UPLC-ESI-QTOFMS) and in rats by gas chromatography-coupled mass spectrometry (GCMS). These markers have been shown to be both dose- and time-dependent. Here UPLC-ESI-QTOFMS was used to analyze rat urine samples taken from 12 rats over 7 days; they were either sham-irradiated or I3I3-irradiated with 3 Gy after 4 days of metabolic cage acclimatization. Using multivariate data analysis, nine urinary biomarkers of I3I3 radiation in rats were identified, including a novel mammalian metabolite, N-acetyltaurine. These upregulated urinary biomarkers were confirmed through tandem mass spectrometry and comparisons with authentic standards. They include thymidine, 2a2a2-deoxyuridine, 2a2a2deoxyxanthosine, N1-acetylspermidine, N-acetylglucosamine/galactosamine-6-sulfate, N-acetyltaurine, N-hexanoylglycine, taurine and, tentatively, isethionic acid. Of these metabolites, 2a2a2-deoxyuridine and thymidine were previously identified in the rat by GCMS (observed as uridine and thymine) and in the mouse by UPLC-ESI-QTOFMS. 2a2a2Deoxyxanthosine, taurine and N-hexanoylglycine were also seen in the mouse by UPLC-ESI-QTOFMS. These are now unequivocal cross-species biomarkers for ionizing radiation exposure. Downregulated biomarkers were shown to be related to food deprivation and starvation mechanisms. The UPLC-ESI-QTOFMS approach has aided in the advance for finding common biomarkers of ionizing radiation exposure. JF - Radiation Research AU - Johnson, Caroline H AU - Patterson, Andrew D AU - Krausz, Kristopher W AU - Lanz, Christian AU - Kang, Dong Wook AU - Luecke, Hans AU - Gonzalez, Frank J AU - Idle, Jeffrey R AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda Maryland 20892 PY - 2011 SP - 473 EP - 484 PB - Radiation Research Society VL - 175 IS - 4 SN - 0033-7587, 0033-7587 KW - Toxicology Abstracts KW - Starvation KW - Data processing KW - Dietary restrictions KW - Acclimatization KW - Metabolites KW - N-Acetylglucosamine KW - Thymine KW - biomarkers KW - Mass spectroscopy KW - Taurine KW - Urine KW - Ionizing radiation KW - gamma Radiation KW - Uridine KW - Thymidine KW - metabolomics KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1758238408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Radiation+Metabolomics.+4.+UPLC-ESI-QTOFMS-Based+Metabolomics+for+Urinary+Biomarker+Discovery+in+Gamma-Irradiated+Rats&rft.au=Johnson%2C+Caroline+H%3BPatterson%2C+Andrew+D%3BKrausz%2C+Kristopher+W%3BLanz%2C+Christian%3BKang%2C+Dong+Wook%3BLuecke%2C+Hans%3BGonzalez%2C+Frank+J%3BIdle%2C+Jeffrey+R&rft.aulast=Johnson&rft.aufirst=Caroline&rft.date=2011-02-01&rft.volume=175&rft.issue=4&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR2437.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Number of references - 1 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Starvation; Data processing; Dietary restrictions; Acclimatization; Metabolites; N-Acetylglucosamine; Thymine; biomarkers; Mass spectroscopy; Taurine; Urine; Ionizing radiation; gamma Radiation; Uridine; metabolomics; Thymidine DO - http://dx.doi.org/10.1667/RR2437.1 ER - TY - JOUR T1 - Is Human Cell Therapy Research Caught in a Mousetrap? AN - 1668268842; PQ0001269824 AB - About 65 million years ago, an asteroid the size of a city hit the Yucatan Peninsula, leading to the extinction of the dinosaurs. The impact fortuitously brought evolutionary opportunities for the last common ancestor of humans and mice to set out on the great radiation of mammals that today humans seem to be doing their best to deplete. Meanwhile, the mouse has been widely adopted as a model animal for understanding mammalian biology. Mice are at the forefront of animal research for many good reasons, not least their size, cost, life span, and availability in a myriad of well-defined strains. Furthermore, they come with an encyclopedic blueprint of murine biology down to constituent molecules. JF - Molecular Therapy AU - Barrett, A John AU - Melenhorst, J Joseph AD - Allogeneic Stem Cell Transplant Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 7C103, 9000 Rockville Pike, Bethesda, Maryland 20892, USA, barrettjj@mail.nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 224 EP - 227 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 19 IS - 2 SN - 1525-0016, 1525-0016 KW - Biotechnology and Bioengineering Abstracts KW - Radiation KW - Extinction KW - Life span KW - Evolution KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668268842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=Is+Human+Cell+Therapy+Research+Caught+in+a+Mousetrap%3F&rft.au=Barrett%2C+A+John%3BMelenhorst%2C+J+Joseph&rft.aulast=Barrett&rft.aufirst=A&rft.date=2011-02-01&rft.volume=19&rft.issue=2&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=Molecular+Therapy&rft.issn=15250016&rft_id=info:doi/10.1038%2Fmt.2010.304 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Extinction; Radiation; Life span; Evolution DO - http://dx.doi.org/10.1038/mt.2010.304 ER - TY - JOUR T1 - MultiDrug-Resistant 2009 Pandemic Influenza A(H1N1) Viruses Maintain Fitness and Transmissibility in Ferrets AN - 1642612888; 20981122 AB - Background. The 2009 influenza A(H1N1) pandemic called attention to the limited influenza treatment options available, especially in individuals at high risk of severe disease. Neuraminidase inhibitor-resistant seasonal H1N1 viruses have demonstrated the ability to transmit well despite early data indicating that resistance reduces viral fitness. 2009 H1N1 pandemic viruses have sporadically appeared containing resistance to neuraminidase inhibitors and the adamantanes, but the ability of these viruses to replicate, transmit, and cause disease in mammalian hosts has not been fully characterized. Methods. Two pretreatment wild-type viruses and 2 posttreatment multidrug-resistant viruses containing the neuraminidase H275Y mutation collected from immunocompromised patients infected with pandemic influenza H1N1 were tested for viral fitness, pathogenicity, and transmissibility in ferrets. Results. The pretreatment wild-type viruses and posttreatment resistant viruses containing the H275Y mutation all demonstrated significant pathogenicity and equivalent viral fitness and transmissibility. Conclusions. The admantane-resistant 2009 pandemic influenza A(H1N1) virus can develop the H275Y change in the neuraminidase gene conferring resistance to both oseltamivir and peramivir without any loss in fitness, transmissibility, or pathogenicity. This suggests that the dissemination of widespread multidrug resistance similar to neuraminidase inhibitor resistance in seasonal H1N1 is a significant threat. JF - Journal of Infectious Diseases AU - Memoli, Matthew J AU - Davis, A Sally AU - Proudfoot, Kathleen AU - Chertow, Daniel S AU - Hrabal, Rachel J AU - Bristol, Tyler AU - Taubenberger, Jeffery K AD - Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892; Respiratory Virus Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MSC 3203 33 North Dr, Bethesda, MD, memolim@niaid.nih.gov Y1 - 2011/02/01/ PY - 2011 DA - 2011 Feb 01 SP - 348 EP - 357 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 203 IS - 3 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Fitness KW - Data processing KW - Drug resistance KW - Viruses KW - Disease resistance KW - Oseltamivir KW - Influenza KW - pandemics KW - Sulfur dioxide KW - Mustela KW - Infectious diseases KW - Pathogenicity KW - Risk factors KW - Immunocompromised hosts KW - Multidrug resistance KW - Exo- alpha -sialidase KW - Seasonal variations KW - Mutation KW - H 0500:General KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642612888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=MultiDrug-Resistant+2009+Pandemic+Influenza+A%28H1N1%29+Viruses+Maintain+Fitness+and+Transmissibility+in+Ferrets&rft.au=Memoli%2C+Matthew+J%3BDavis%2C+A+Sally%3BProudfoot%2C+Kathleen%3BChertow%2C+Daniel+S%3BHrabal%2C+Rachel+J%3BBristol%2C+Tyler%3BTaubenberger%2C+Jeffery+K&rft.aulast=Memoli&rft.aufirst=Matthew&rft.date=2011-02-01&rft.volume=203&rft.issue=3&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiq067 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Fitness; Data processing; Drug resistance; Disease resistance; Oseltamivir; Influenza; pandemics; Pathogenicity; Immunocompromised hosts; Risk factors; Multidrug resistance; Exo- alpha -sialidase; Mutation; Sulfur dioxide; Infectious diseases; Viruses; Seasonal variations; Mustela DO - http://dx.doi.org/10.1093/infdis/jiq067 ER - TY - JOUR T1 - Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma AN - 1550193721; 21194740 AB - Background Improvement in lung function after macrolide antibiotic therapy has been attributed to reduction in bronchial infection by specific bacteria. However, the airway might be populated by a more diverse microbiota, and clinical features of asthma might be associated with characteristics of the airway microbiota present. Objective We sought to determine whether relationships exist between the composition of the airway bacterial microbiota and clinical features of asthma using culture-independent tools capable of detecting the presence and relative abundance of most known bacteria. Methods In this pilot study bronchial epithelial brushings were collected from 65 adults with suboptimally controlled asthma participating in a multicenter study of the effects of clarithromycin on asthma control and 10 healthy control subjects. A combination of high-density 16S ribosomal RNA microarray and parallel clone library-sequencing analysis was used to profile the microbiota and examine relationships with clinical measurements. Results Compared with control subjects, 16S ribosomal RNA amplicon concentrations (a proxy for bacterial burden) and bacterial diversity were significantly higher among asthmatic patients. In multivariate analyses airway microbiota composition and diversity were significantly correlated with bronchial hyperresponsiveness. Specifically, the relative abundance of particular phylotypes, including members of the Comamonadaceae, Sphingomonadaceae, Oxalobacteraceae, and other bacterial families were highly correlated with the degree of bronchial hyperresponsiveness. Conclusion: The composition of bronchial airway microbiota is associated with the degree of bronchial hyperresponsiveness among patients with suboptimally controlled asthma. These findings support the need for further functional studies to examine the potential contribution of members of the airway microbiota in asthma pathogenesis. JF - Journal of Allergy and Clinical Immunology AU - Huang, Yvonne J AU - Nelson, Craig E AU - Brodie, Eoin L AU - DeSantis, Todd Z AU - Baek, Marshall S AU - Liu, Jane AU - Woyke, Tanja AU - Allgaier, Martin AU - Bristow, Jim AU - Wiener-Kronish, Jeanine P AU - Sutherland, E Rand AU - King, Tonya S AU - Icitovic, Nikolina AU - Martin, Richard J AU - Calhoun, William J AU - Castro, Mario AU - Denlinger, Loren C AU - DiMango, Emily AU - Kraft, Monica AU - Peters, Stephen P AU - Wasserman, Stephen I AU - Wechsler, Michael E AU - Boushey, Homer A AU - Lynch, Susan V Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 372 EP - 381.e1-3 CY - St. Louis PB - Elsevier Science Ltd. VL - 127 IS - 2 SN - 00916749 KW - Abstracting And Indexing Services KW - RNA, Ribosomal, 16S KW - Clarithromycin KW - Asthma KW - Studies KW - Pathogenesis KW - Bacteria KW - Infections KW - Cloning KW - Community KW - Phylogenetics KW - Phylogeny KW - RNA, Ribosomal, 16S -- genetics KW - Asthma -- drug therapy KW - Oligonucleotide Array Sequence Analysis KW - Clarithromycin -- pharmacology KW - Humans KW - Adult KW - Pilot Projects KW - Male KW - Female KW - Asthma -- microbiology KW - Bronchial Hyperreactivity -- microbiology KW - Bronchi -- microbiology KW - Asthma -- etiology KW - Bacteria -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1550193721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=Airway+microbiota+and+bronchial+hyperresponsiveness+in+patients+with+suboptimally+controlled+asthma&rft.au=Huang%2C+Yvonne+J%3BNelson%2C+Craig+E%3BBrodie%2C+Eoin+L%3BDeSantis%2C+Todd+Z%3BBaek%2C+Marshall+S%3BLiu%2C+Jane%3BWoyke%2C+Tanja%3BAllgaier%2C+Martin%3BBristow%2C+Jim%3BWiener-Kronish%2C+Jeanine+P%3BSutherland%2C+E+Rand%3BKing%2C+Tonya+S%3BIcitovic%2C+Nikolina%3BMartin%2C+Richard+J%3BCalhoun%2C+William+J%3BCastro%2C+Mario%3BDenlinger%2C+Loren+C%3BDiMango%2C+Emily%3BKraft%2C+Monica%3BPeters%2C+Stephen+P%3BWasserman%2C+Stephen+I%3BWechsler%2C+Michael+E%3BBoushey%2C+Homer+A%3BLynch%2C+Susan+V&rft.aulast=Huang&rft.aufirst=Yvonne&rft.date=2011-02-01&rft.volume=127&rft.issue=2&rft.spage=372&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/10.1016%2Fj.jaci.2010.10.048 LA - English DB - ProQuest Central N1 - Copyright - Copyright Elsevier Limited Feb 2011 N1 - Last updated - 2014-09-25 DO - http://dx.doi.org/10.1016/j.jaci.2010.10.048 ER - TY - JOUR T1 - Magnetic resonance imaging of organic contrast agents in mice: capturing the whole-body redox landscape AN - 1093472559; 14261121 AB - Nitroxides are a class of stable free radicals that have several biomedical applications including radioprotection and noninvasive assessment of tissue redox status. For both of these applications, it is necessary to understand the in vivo biodistribution and reduction of nitroxides. In this study, magnetic resonance imaging was used to compare tissue accumulation (concentration) and reduction of two commonly studied nitroxides: the piperidine nitroxide Tempol and the pyrrolidine nitroxide 3-CP. It was found that 3-CP was reduced 3 to 11 times slower (depending on the tissue) than Tempol in vivo and that maximum tissue concentration varies substantially between tissues (0.6-7.2 mM). For a given tissue, the maximum concentration usually did not vary between the two nitroxides. Furthermore, using electron paramagnetic resonance spectroscopy, we showed that the nitroxide reduction rate depends only weakly on cellular pO sub(2) in the oxygen range expected in vivo. These observations, taken with the marked variation in nitroxide reduction rates observed between tissues, suggest that tissue pO sub(2) is not a major determinant of the nitroxide reduction rate in vivo. For the purpose of redox imaging, 3-CP was shown to be an optimal choice based on the achievable concentrations and bioreduction observed in vivo. JF - Free Radical Biology and Medicine AU - Davis, Ryan M AU - Matsumoto, Shingo AU - Bernardo, Marcelino AU - Sowers, Anastasia AU - Matsumoto, Ken-Ichiro AU - Krishna, Murali C AU - Mitchell, James B AD - Radiation Biology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA, davisrm2@mail.nih.gov Y1 - 2011/02/01/ PY - 2011 DA - 2011 Feb 01 SP - 459 EP - 468 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 50 IS - 3 SN - 0891-5849, 0891-5849 KW - Toxicology Abstracts KW - Contrast media KW - E.S.R. KW - Free radicals KW - Landscape KW - Magnetic resonance imaging KW - Nitroxide KW - Oxygen KW - Piperidine KW - Radioprotection KW - Spectroscopy KW - tempol KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1093472559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+Radical+Biology+and+Medicine&rft.atitle=Magnetic+resonance+imaging+of+organic+contrast+agents+in+mice%3A+capturing+the+whole-body+redox+landscape&rft.au=Davis%2C+Ryan+M%3BMatsumoto%2C+Shingo%3BBernardo%2C+Marcelino%3BSowers%2C+Anastasia%3BMatsumoto%2C+Ken-Ichiro%3BKrishna%2C+Murali+C%3BMitchell%2C+James+B&rft.aulast=Davis&rft.aufirst=Ryan&rft.date=2011-02-01&rft.volume=50&rft.issue=3&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Free+Radical+Biology+and+Medicine&rft.issn=08915849&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2010.11.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2012-10-08 N1 - SubjectsTermNotLitGenreText - E.S.R.; Oxygen; tempol; Piperidine; Free radicals; Landscape; Radioprotection; Magnetic resonance imaging; Contrast media; Spectroscopy; Nitroxide DO - http://dx.doi.org/10.1016/j.freeradbiomed.2010.11.028 ER - TY - JOUR T1 - Sleep disturbances in adults with arthritis: Prevalence, mediators, and subgroups at greatest risk. Data from the 2007 National Health Interview Survey AN - 1032903852; 16721002 AB - Objective To examine the prevalence of sleep disturbances in adults with arthritis in a nationally representative sample, mediators of sleep difficulties, and subgroups of individuals with arthritis at greatest risk. Methods Using data on US adults ages >=18 years participating in the 2007 National Health Interview Survey, we computed the prevalence of 3 measures of sleep disturbance (insomnia, excessive daytime sleepiness, and sleep duration <6 hours) among persons with arthritis. We used logistic regression analysis to examine if the association of arthritis and sleep disturbances was independent of sociodemographic characteristics and comorbidities, and to identify potential mediators. We used classification trees to identify subgroups at higher risk. Results The adjusted prevalence of insomnia was higher among adults with arthritis than those without arthritis (23.1% versus 16.4%; P < 0.0001), but was similar to those with other chronic diseases. Adults with arthritis were more likely than those without arthritis to report insomnia (unadjusted odds ratio 2.92, 95% confidence interval 2.68-3.17), but adjustment for sociodemographic characteristics and comorbidities attenuated this association. Joint pain and limitation due to pain mediated the association between arthritis and insomnia. Among adults with arthritis, those with depression and anxiety were at highest risk for sleep disturbance. Results for excessive daytime sleepiness and sleep duration <6 hours were similar. Conclusion Sleep disturbance affects up to 10.2 million US adults with arthritis, and is mediated by joint pain and limitation due to pain. Among individuals with arthritis, those with depression and anxiety are at greatest risk. JF - Arthritis Care & Research AU - Louie, Grant H AU - Tektonidou, Maria G AU - Caban-Martinez, Alberto J AU - Ward, Michael M AD - National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, glouie2@jhmi.edu Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 247 EP - 260 PB - Wiley-Blackwell, Baffins Lane Chichester W. Sussex PO19 1UD United Kingdom VL - 63 IS - 2 SN - 2151-4658, 2151-4658 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - Depression KW - Disturbance KW - Morbidity KW - Pain KW - H 0500:General KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1032903852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+Care+%26+Research&rft.atitle=Sleep+disturbances+in+adults+with+arthritis%3A+Prevalence%2C+mediators%2C+and+subgroups+at+greatest+risk.+Data+from+the+2007+National+Health+Interview+Survey&rft.au=Louie%2C+Grant+H%3BTektonidou%2C+Maria+G%3BCaban-Martinez%2C+Alberto+J%3BWard%2C+Michael+M&rft.aulast=Louie&rft.aufirst=Grant&rft.date=2011-02-01&rft.volume=63&rft.issue=2&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Arthritis+Care+%26+Research&rft.issn=21514658&rft_id=info:doi/10.1002%2Facr.20362 L2 - http://onlinelibrary.wiley.com/doi/10.1002/acr.20362/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Last updated - 2012-09-10 N1 - SubjectsTermNotLitGenreText - Age; Depression; Pain; Disturbance; Morbidity DO - http://dx.doi.org/10.1002/acr.20362 ER - TY - JOUR T1 - Insecticide use and risk of rheumatoid arthritis and systemic lupus erythematosus in the Women's Health Initiative Observational Study AN - 1032903846; 16720994 AB - Objective Farming and agricultural pesticide use has been associated with 2 autoimmune rheumatic diseases, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). However, risk associated with other residential or work place insecticide use is unknown. Methods We analyzed data from the Women's Health Initiative Observational Study (n = 76,861 postmenopausal women, ages 50-79 years). Incident cases (n = 213: 178 for RA, 27 for SLE, and 8 for both) were identified based on self-report and use of disease-modifying antirheumatic drugs at year 3 of followup. We examined self-reported residential or work place insecticide use (personally mixing/applying by self and application by others) in relation to RA/SLE risk, overall and in relation to farm history. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were adjusted for age, race, region, education, occupation, smoking, reproductive factors, asthma, other autoimmune diseases, and comorbidities. Results Compared with never used, personal use of insecticides was associated with increased RA/SLE risk, with significant trends for greater frequency (HR 2.04, 95% CI 1.17-3.56 for >=6 times/year) and duration (HR 1.97, 95% CI 1.20-3.23 for >=20 years). Risk was also associated with long-term insecticide application by others (HR 1.85, 95% CI 1.07-3.20 for >=20 years) and frequent application by others among women with a farm history (HR 2.73, 95% CI 1.10-6.78 for >=6 times/year). Conclusion These results suggest residential and work place insecticide exposure is associated with the risk of autoimmune rheumatic diseases in postmenopausal women. Although these findings require replication in other populations, they support a role for environmental pesticide exposure in the development of autoimmune rheumatic diseases. JF - Arthritis Care & Research AU - Parks, Christine G AU - Walitt, Brian T AU - Pettinger, Mary AU - Chen, Jiu-Chiuan AU - de Roos, Anneclaire J AU - Hunt, Julie AU - Sarto, Gloria AU - Howard, Barbara V AD - National Institute for Environmental Health Science, Durham, North Carolina, parks1@mail.nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 184 EP - 194 PB - Wiley-Blackwell, Baffins Lane Chichester W. Sussex PO19 1UD United Kingdom VL - 63 IS - 2 SN - 2151-4658, 2151-4658 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - Farms KW - Historical account KW - Insecticides KW - Morbidity KW - Pesticides KW - Post-menopause KW - Respiratory diseases KW - Rheumatoid arthritis KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1032903846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+Care+%26+Research&rft.atitle=Insecticide+use+and+risk+of+rheumatoid+arthritis+and+systemic+lupus+erythematosus+in+the+Women%27s+Health+Initiative+Observational+Study&rft.au=Parks%2C+Christine+G%3BWalitt%2C+Brian+T%3BPettinger%2C+Mary%3BChen%2C+Jiu-Chiuan%3Bde+Roos%2C+Anneclaire+J%3BHunt%2C+Julie%3BSarto%2C+Gloria%3BHoward%2C+Barbara+V&rft.aulast=Parks&rft.aufirst=Christine&rft.date=2011-02-01&rft.volume=63&rft.issue=2&rft.spage=184&rft.isbn=&rft.btitle=&rft.title=Arthritis+Care+%26+Research&rft.issn=21514658&rft_id=info:doi/10.1002%2Facr.20335 L2 - http://onlinelibrary.wiley.com/doi/10.1002/acr.20335/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Last updated - 2012-09-10 N1 - SubjectsTermNotLitGenreText - Historical account; Rheumatoid arthritis; Age; Farms; Insecticides; Post-menopause; Pesticides; Respiratory diseases; Morbidity DO - http://dx.doi.org/10.1002/acr.20335 ER - TY - JOUR T1 - Exploitation of the Ubiquitin System by Invading Bacteria AN - 1028075510; 14228193 AB - A variety of bacterial intracellular pathogens target the host cell ubiquitin system during invasion, a process that involves transient but fundamental changes in the actin cytoskeleton and plasma membrane. These changes are induced by bacterial proteins, which can be surface associated, secreted or injected directly into the host cell. Here, the invasion strategies of two extensively studied intracellular bacteria, Salmonella enterica serovar Typhimurium and Listeria monocytogenes, are used to illustrate some of the diverse ways by which bacterial pathogens intersect the host cell ubiquitin pathway. JF - Traffic AU - Steele-Mortimer, Olivia AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA, omortimeriaid.nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 162 EP - 169 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 12 IS - 2 SN - 1398-9219, 1398-9219 KW - Microbiology Abstracts B: Bacteriology KW - Actin KW - Cytoskeleton KW - Pathogens KW - Plasma membranes KW - Ubiquitin KW - Listeria monocytogenes KW - Salmonella enterica KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028075510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traffic&rft.atitle=Exploitation+of+the+Ubiquitin+System+by+Invading+Bacteria&rft.au=Steele-Mortimer%2C+Olivia&rft.aulast=Steele-Mortimer&rft.aufirst=Olivia&rft.date=2011-02-01&rft.volume=12&rft.issue=2&rft.spage=162&rft.isbn=&rft.btitle=&rft.title=Traffic&rft.issn=13989219&rft_id=info:doi/10.1111%2Fj.1600-0854.2010.01137.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Document feature - figure 3 N1 - Last updated - 2012-07-27 N1 - SubjectsTermNotLitGenreText - Cytoskeleton; Plasma membranes; Actin; Pathogens; Ubiquitin; Listeria monocytogenes; Salmonella enterica DO - http://dx.doi.org/10.1111/j.1600-0854.2010.01137.x ER - TY - JOUR T1 - SPICE: Exploration and analysis of post-cytometric complex multivariate datasets AN - 1017970113; 16714516 AB - Polychromatic flow cytometry results in complex, multivariate datasets. To date, tools for the aggregate analysis of these datasets across multiple specimens grouped by different categorical variables, such as demographic information, have not been optimized. Often, the exploration of such datasets is accomplished by visualization of patterns with pie charts or bar charts, without easy access to statistical comparisons of measurements that comprise multiple components. Here we report on algorithms and a graphical interface we developed for these purposes. In particular, we discuss thresholding necessary for accurate representation of data in pie charts, the implications for display and comparison of normalized versus unnormalized data, and the effects of averaging when samples with significant background noise are present. Finally, we define a statistic for the nonparametric comparison of complex distributions to test for difference between groups of samples based on multi-component measurements. While originally developed to support the analysis of T cell functional profiles, these techniques are amenable to a broad range of datatypes. Published 2011 Wiley-Liss, Inc. JF - Cytometry Part A AU - Roederer, Mario AU - Nozzi, Joshua L AU - Nason, Martha C AD - ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, Roederer@nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 167 EP - 174 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 79A IS - 2 SN - 1552-4930, 1552-4930 KW - Biotechnology and Bioengineering Abstracts KW - Algorithms KW - Data processing KW - Demography KW - Flow cytometry KW - Lymphocytes T KW - Spices KW - Statistics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017970113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+A&rft.atitle=SPICE%3A+Exploration+and+analysis+of+post-cytometric+complex+multivariate+datasets&rft.au=Roederer%2C+Mario%3BNozzi%2C+Joshua+L%3BNason%2C+Martha+C&rft.aulast=Roederer&rft.aufirst=Mario&rft.date=2011-02-01&rft.volume=79A&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+A&rft.issn=15524930&rft_id=info:doi/10.1002%2Fcyto.a.21015 L2 - http://onlinelibrary.wiley.com/doi/10.1002/cyto.a.21015/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Demography; Flow cytometry; Statistics; Data processing; Spices; Lymphocytes T; Algorithms DO - http://dx.doi.org/10.1002/cyto.a.21015 ER - TY - JOUR T1 - Risk of cancer in a large cohort of U.S. veterans with diabetes AN - 1017966925; 16690183 AB - Prior studies of cancer risk among diabetic men have reported inconsistent findings. The aim of this study was to assess the risk of cancer among a large cohort (n = 4,501,578) of black and white U.S. veterans admitted to Veterans Affairs hospitals. The cancer risk among men with diabetes (n = 594,815) was compared to the risk among men without diabetes (n = 3,906,763). Poisson regression was used to estimate adjusted relative risks (RRs) and 95% confidence intervals (CIs). Overall, men with diabetes had a significantly lower risk of cancer (RR = 0.93, 95%CI = 0.93-0.94). Men with diabetes, however, had increased risks of cancers of the liver (RR = 1.95, 95%CI = 1.82-2.09), pancreas (RR = 1.50, 95%CI = 1.42-1.59), biliary tract (RR = 1.41, 95%CI = 1.22-1.62), colon (RR = 1.20, 95%CI = 1.16-1.25), rectum (RR = 1.12, 95%CI = 1.07-1.18), and kidney (RR = 1.09, 95%CI = 1.03-1.16), as well as leukemia (RR = 1.14, 95%CI = 1.08-1.21) and melanoma (RR = 1.13, 95%CI = 1.03-1.24). In contrast, men with diabetes had decreased risks of cancers of the prostate (RR = 0.89, 95%CI = 0.87-0.91), brain (RR = 0.91, 95% CI = 0.82-0.99), buccal cavity (RR = 0.85, 95%CI = 0.82-0.89), lung (RR = 0.79, 95%CI = 0.77-0.80), esophagus (RR = 0.77, 95%CI = 0.72-0.82), and larynx (RR = 0.76, 95%CI = 0.71-0.80). These findings indicate that black and white men with diabetes are at significantly lower risk of total cancer and of two of the most common cancers among U.S. males; lung and prostate cancers. These decreased risks were offset, however, by increased risks of cancer at several sites. Hyperinsulinemia may explain the increased risks of the digestive cancers, while lower testosterone levels, in the case of prostate cancer, and higher BMI, in the case of lung cancer, may explain the decreased risks of those tumors. JF - International Journal of Cancer AU - Atchison, Elizabeth A AU - Gridley, Gloria AU - Carreon, J Daniel AU - Leitzmann, Michael F AU - McGlynn, Katherine A AD - Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD, mcglynnk@mail.nih.gov Y1 - 2011/02/01/ PY - 2011 DA - 2011 Feb 01 SP - 635 EP - 643 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 128 IS - 3 SN - 1097-0215, 1097-0215 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Brain KW - Cancer KW - Diabetes mellitus KW - Hospitals KW - Kidney KW - Leukemia KW - Liver KW - Lung cancer KW - diabetes mellitus KW - melanoma KW - prostate cancer KW - tumors KW - USA KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017966925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Risk+of+cancer+in+a+large+cohort+of+U.S.+veterans+with+diabetes&rft.au=Atchison%2C+Elizabeth+A%3BGridley%2C+Gloria%3BCarreon%2C+J+Daniel%3BLeitzmann%2C+Michael+F%3BMcGlynn%2C+Katherine+A&rft.aulast=Atchison&rft.aufirst=Elizabeth&rft.date=2011-02-01&rft.volume=128&rft.issue=3&rft.spage=635&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=10970215&rft_id=info:doi/10.1002%2Fijc.25362 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ijc.25362/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Leukemia; diabetes mellitus; Liver; Kidney; Brain; tumors; melanoma; prostate cancer; Cancer; Hospitals; Lung cancer; USA DO - http://dx.doi.org/10.1002/ijc.25362 ER - TY - JOUR T1 - Interpretation of cellular proliferation data: Avoid the panglossian AN - 1017964702; 16714509 AB - There are several statistics that may be calculated to characterize a cellular proliferation experiment. By far, the most commonly-reported statistic is the percent of cells in the final culture that have divided; however, this statistic has significant limitations. Other statistics provided by software modeling provide a much richer characterization of the biological response; however, their use also comes with caveats. Here, I discuss the practical application of these statistics, including their limitations and interdependencies, using hypothetical data. The goal of this perspective is to prevent the blind reliance or overly optimistic ('panglossian') interpretation of the statistics generated by software, so that researchers and reviewers have a more-informed basis for drawing conclusions from the data. Published 2011 Wiley-Liss, Inc. JF - Cytometry Part A AU - Roederer, Mario Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 95 EP - 101 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 79A IS - 2 SN - 1552-4930, 1552-4930 KW - Biotechnology and Bioengineering Abstracts KW - Cell culture KW - Computer programs KW - Cytometry KW - Data processing KW - Statistics KW - software KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017964702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+A&rft.atitle=Interpretation+of+cellular+proliferation+data%3A+Avoid+the+panglossian&rft.au=Roederer%2C+Mario&rft.aulast=Roederer&rft.aufirst=Mario&rft.date=2011-02-01&rft.volume=79A&rft.issue=2&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+A&rft.issn=15524930&rft_id=info:doi/10.1002%2Fcyto.a.21010 L2 - http://onlinelibrary.wiley.com/doi/10.1002/cyto.a.21010/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Computer programs; software; Data processing; Statistics; Cell culture; Cytometry DO - http://dx.doi.org/10.1002/cyto.a.21010 ER - TY - JOUR T1 - The Development and Characterization of a Human Mesothelioma In Vitro 3D Model to Investigate Immunotoxin Therapy AN - 907154956; 14389904 AB - Tumor microenvironments present significant barriers to penetration by antibodies and immunoconjugates. Tumor microenvironments, however, are difficult to study in vitro. Cells cultured as monolayers exhibit less resistance to therapy than those grown in vivo and an alternative research model more representative of the in vivo tumor is more desirable. SS1P is an immunotoxin composed of the Fv portion of a mesothelin-specific antibody fused to a bacterial toxin that is presently undergoing clinical trials in mesothelioma. Here, we examined how the tumor microenvironment affects the penetration and killing activity of SS1P in a new three-dimensional (3D) spheroid model cultured in vitro using the human mesothelioma cell line (NCI-H226) and two primary cell lines isolated from the ascites of malignant mesothelioma patients. Mesothelioma cells grown as monolayers or as spheroids expressed comparable levels of mesothelin; however, spheroids were at least 100 times less affected by SS1P. To understand this disparity in cytotoxicity, we made fluorescence-labeled SS1P molecules and used confocal microscopy to examine the time course of SS1P penetration within spheroids. The penetration was limited after 4 hours. Interestingly, we found a significant increase in the number of tight junctions in the core area of spheroids by electron microscopy. Expression of E-Cadherin, a protein involved in the assembly and sealing of tight junctions and highly expressed in malignant mesothelioma, was found significantly increased in spheroids as compared to monolayers. Moreover, we found that siRNA silencing and antibody inhibition targeting E-Cadherin could enhance SS1P immunotoxin therapy in vitro. This work is one of the first to investigate immunotoxins in 3D tumor spheroids in vitro. This initial description of an in vitro tumor model may offer a simple and more representative model of in vivo tumors and will allow for further investigations of the microenvironmental effects on drug penetration and tumor cell killing. We believe that the methods developed here may apply to the studies of other tumor-targeting antibodies and immunoconjugates in vitro. JF - PLoS ONE AU - Xiang, Xinran AU - Phung, Yen AU - Feng, Mingqian AU - Nagashima, Kunio AU - Zhang, Jingli AU - Broaddus, VCourtney AU - Hassan, Raffit AU - FitzGerald, David AU - Ho, Mitchell AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2011/01/31/ PY - 2011 DA - 2011 Jan 31 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 6 IS - 1 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Tight junctions KW - Tumors KW - Clinical trials KW - Tumor cells KW - E-Cadherin KW - Immunotoxins KW - Fv KW - Toxins KW - Antibodies KW - Cytotoxicity KW - siRNA KW - Cores KW - Ascites KW - Confocal microscopy KW - Microenvironments KW - mesothelioma KW - spheroids KW - Drugs KW - Immunoconjugates KW - Electron microscopy KW - J 02410:Animal Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907154956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=The+Development+and+Characterization+of+a+Human+Mesothelioma+In+Vitro+3D+Model+to+Investigate+Immunotoxin+Therapy&rft.au=Xiang%2C+Xinran%3BPhung%2C+Yen%3BFeng%2C+Mingqian%3BNagashima%2C+Kunio%3BZhang%2C+Jingli%3BBroaddus%2C+VCourtney%3BHassan%2C+Raffit%3BFitzGerald%2C+David%3BHo%2C+Mitchell&rft.aulast=Xiang&rft.aufirst=Xinran&rft.date=2011-01-31&rft.volume=6&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0014640 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Tight junctions; Tumors; Tumor cells; Clinical trials; Toxins; Fv; Immunotoxins; E-Cadherin; Cytotoxicity; Antibodies; Cores; siRNA; Ascites; Confocal microscopy; mesothelioma; Microenvironments; spheroids; Drugs; Electron microscopy; Immunoconjugates DO - http://dx.doi.org/10.1371/journal.pone.0014640 ER - TY - JOUR T1 - Nr4a1-eGFP Is a Marker of Striosome-Matrix Architecture, Development and Activity in the Extended Striatum AN - 923197129; 14389881 AB - Transgenic mice expressing eGFP under population specific promoters are widely used in neuroscience to identify specific subsets of neurons in situ and as sensors of neuronal activity in vivo. Mice expressing eGFP from a bacterial artificial chromosome under the Nr4a1 promoter have high expression within the basal ganglia, particularly within the striosome compartments and striatal-like regions of the extended amygdala (bed nucleus of the stria terminalis, striatal fundus, central amygdaloid nucleus and intercalated cells). Grossly, eGFP expression is inverse to the matrix marker calbindin 28K and overlaps with mu-opioid receptor immunoreactivity in the striatum. This pattern of expression is similar to Drd1, but not Drd2, dopamine receptor driven eGFP expression in structures targeted by medium spiny neuron afferents. Striosomal expression is strong developmentally where Nr4a1-eGFP expression overlaps with Drd1, TrkB, tyrosine hydroxylase and phospho-ERK, but not phospho-CREB, immunoreactivity in "dopamine islands". Exposure of adolescent mice to methylphenidate resulted in an increase in eGFP in both compartments in the dorsolateral striatum but eGFP expression remained brighter in the striosomes. To address the role of activity in Nr4a1-eGFP expression, primary striatal cultures were prepared from neonatal mice and treated with forskolin, BDNF, SKF-83822 or high extracellular potassium and eGFP was measured fluorometrically in lysates. eGFP was induced in both neurons and contaminating glia in response to forskolin but SKF-83822, brain derived neurotrophic factor and depolarization increased eGFP in neuronal-like cells selectively. High levels of eGFP were primarily associated with Drd1+ neurons in vitro detected by immunofluorescence; however similar to 15% of the brightly expressing cells contained punctate met-enkephalin immunoreactivity. The Nr4a1-GFP mouse strain will be a useful model for examining the connectivity, physiology, activity and development of the striosome system. JF - PLoS ONE AU - Davis, Margaret I AU - Puhl, Henry L AD - Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2011/01/28/ PY - 2011 DA - 2011 Jan 28 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 6 IS - 1 KW - Microbiology Abstracts B: Bacteriology KW - Dopamine D2 receptors KW - Dopamine D1 receptors KW - Methylphenidate KW - Cell culture KW - Dopamine receptors KW - Enkephalin (methionine) KW - Promoters KW - Nervous system KW - Dopamine KW - spiny neurons KW - Neostriatum KW - Immunoreactivity KW - bed nucleus KW - Stria terminalis KW - Brain-derived neurotrophic factor KW - Sensory neurons KW - Neural networks KW - Adolescence KW - Neurotrophic factors KW - Potassium KW - Immunofluorescence KW - Transgenic mice KW - Bacterial artificial chromosomes KW - TrkB receptors KW - Calbindin-D28K KW - Amygdala KW - Opioid receptors (type mu) KW - Tyrosine 3-monooxygenase KW - Basal ganglia KW - Forskolin KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/923197129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Nr4a1-eGFP+Is+a+Marker+of+Striosome-Matrix+Architecture%2C+Development+and+Activity+in+the+Extended+Striatum&rft.au=Davis%2C+Margaret+I%3BPuhl%2C+Henry+L&rft.aulast=Davis&rft.aufirst=Margaret&rft.date=2011-01-28&rft.volume=6&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0016619 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Dopamine D2 receptors; Dopamine D1 receptors; Methylphenidate; Cell culture; Dopamine receptors; Enkephalin (methionine); Promoters; Nervous system; Dopamine; spiny neurons; Immunoreactivity; Neostriatum; bed nucleus; Brain-derived neurotrophic factor; Stria terminalis; Sensory neurons; Neural networks; Adolescence; Neurotrophic factors; Potassium; Immunofluorescence; Transgenic mice; Bacterial artificial chromosomes; Calbindin-D28K; TrkB receptors; Opioid receptors (type mu); Amygdala; Tyrosine 3-monooxygenase; Basal ganglia; Forskolin DO - http://dx.doi.org/10.1371/journal.pone.0016619 ER - TY - JOUR T1 - Ectopic Mineralization in the Middle Ear and Chronic Otitis Media with Effusion Caused by RPL38 Deficiency in the Tail-short (Ts) Mouse AN - 1017956331; 14268057 AB - Inflammation of the middle ear cavity (otitis media) and the abnormal deposition of bone at the otic capsule are common causes of conductive hearing impairment in children and adults. Although a host of environmental factors can contribute to these conditions, a genetic predisposition has an important role as well. Here, we analyze the Tail-short (Ts) mouse, which harbors a spontaneous semi-dominant mutation that causes skeletal defects and hearing loss. By genetic means, we show that the Ts phenotypes arise from an 18-kb deletion/insertion of the Rpl38 gene, encoding a ribosomal protein of the large subunit. We show that Ts mutants exhibit significantly elevated auditory-brain stem response thresholds and reduced distortion-product otoacoustic emissions, in the presence of normal endocochlear potentials and typical inner ear histology suggestive of a conductive hearing impairment. We locate the cause of the hearing impairment to the middle ear, demonstrating over-ossification at the round window ridge, ectopic deposition of cholesterol crystals in the middle ear cavity, enlarged Eustachian tube, and chronic otitis media with effusion all beginning at around 3 weeks after birth. Using specific antisera, we demonstrate that Rpl38 is an similar to 8-kDa protein that is predominantly expressed in mature erythrocytes. Finally, using an Rpl38 cDNA transgene, we rescue the Ts phenotypes. Together, these data present a previously uncharacterized combination of interrelated middle ear pathologies and suggest Rpl38 deficiency as a model to dissect the causative relationships between neo-ossification, cholesterol crystal deposition, and Eustachian tubes in the etiology of otitis media. JF - Journal of Biological Chemistry AU - Noben-Trauth, Konrad AU - Latoche, Joseph R AD - From the Section on Neurogenetics, Laboratory of Molecular Biology, NIDCD, National Institutes of Health, Rockville, Maryland 20850 Y1 - 2011/01/28/ PY - 2011 DA - 2011 Jan 28 SP - 3079 EP - 3093 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 286 IS - 4 SN - 0021-9258, 0021-9258 KW - Toxicology Abstracts KW - Antisera KW - Auditory system KW - Birth KW - Children KW - Cholesterol KW - Crystals KW - Data processing KW - Effusion KW - Erythrocytes KW - Etiology KW - Gene deletion KW - Insertion KW - Middle ear KW - Mineralization KW - Mutation KW - Otitis media KW - Ribosomal proteins KW - Transgenes KW - otoacoustic emissions KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017956331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Ectopic+Mineralization+in+the+Middle+Ear+and+Chronic+Otitis+Media+with+Effusion+Caused+by+RPL38+Deficiency+in+the+Tail-short+%28Ts%29+Mouse&rft.au=Noben-Trauth%2C+Konrad%3BLatoche%2C+Joseph+R&rft.aulast=Noben-Trauth&rft.aufirst=Konrad&rft.date=2011-01-28&rft.volume=286&rft.issue=4&rft.spage=3079&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Etiology; otoacoustic emissions; Data processing; Middle ear; Auditory system; Transgenes; Erythrocytes; Effusion; Crystals; Cholesterol; Mineralization; Children; Birth; Antisera; Gene deletion; Insertion; Ribosomal proteins; Otitis media; Mutation ER - TY - JOUR T1 - Spatiotemporal Evolution of the Functional Magnetic Resonance Imaging Response to Ultrashort Stimuli AN - 907148972; 14300347 AB - The specificity of the hemodynamic response function (HRF) is determined spatially by the vascular architecture and temporally by the evolution of hemodynamic changes. The stimulus duration has additional influence on the spatiotemporal evolution of the HRF, as brief stimuli elicit responses that engage only the local vasculature, whereas long stimuli lead to the involvement of remote vascular supply and drainage. Here, we used functional magnetic resonance imaging to investigate the spatiotemporal evolution of the blood oxygenation level-dependent (BOLD), cerebral blood flow (CBF), and cerebral blood volume (CBV) HRF to ultrashort forelimb stimulation in an anesthetized rodent model. The HRFs to a single 333- mu s-long stimulus were robustly detected and consisted of a rapid response in both CBF and CBV, with an onset time (OT) of 350 ms and a full width at half-maximum of 1 s. In contrast, longer stimuli elicited a dispersive transit of oxygenated blood across the cortical microvasculature that significantly prolonged the evolution of the CBV HRF, but not the CBF. The CBF and CBV OTs suggest that vasoactive messengers are synthesized, released, and effective within 350 ms. However, the difference between the BOLD and CBV OT ( similar to 100 ms) was significantly smaller than the arteriolar-venular transit time ( similar to 500 ms), indicating an arterial contribution to the BOLD HRF. Finally, the rapid rate of growth of the active region with stimulus elongation suggests that functional hyperemia is an integrative process that involves the entire functional cortical depth. These findings offer a new view into the spatiotemporal dynamics of functional hemodynamic regulation in the brain. JF - Journal of Neuroscience AU - Hirano, Yoshiyuki AU - Stefanovic, Bojana AU - Silva, Afonso C AD - Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1065 Y1 - 2011/01/26/ PY - 2011 DA - 2011 Jan 26 SP - 1440 EP - 1447 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Washington DC 20036 USA VL - 31 IS - 4 SN - 0270-6474, 0270-6474 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Elongation KW - Brain mapping KW - Microvasculature KW - Nervous system KW - Functional magnetic resonance imaging KW - Drainage KW - Hemodynamics KW - hyperemia KW - Cerebral blood flow KW - Evolution KW - Vasoactive agents KW - X 24390:Radioactive Materials KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907148972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Spatiotemporal+Evolution+of+the+Functional+Magnetic+Resonance+Imaging+Response+to+Ultrashort+Stimuli&rft.au=Hirano%2C+Yoshiyuki%3BStefanovic%2C+Bojana%3BSilva%2C+Afonso+C&rft.aulast=Hirano&rft.aufirst=Yoshiyuki&rft.date=2011-01-26&rft.volume=31&rft.issue=4&rft.spage=1440&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Microvasculature; Brain mapping; Elongation; Nervous system; Drainage; Functional magnetic resonance imaging; Hemodynamics; hyperemia; Evolution; Cerebral blood flow; Vasoactive agents ER - TY - JOUR T1 - Rotenone, Paraquat, and Parkinson's Disease AN - 896222628; 15090559 AB - Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and genetic forms of Parkinson's disease (PD). Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans. Our goal was to determine whether pesticides that cause mitochondrial dysfunction or oxidative stress are associated with PD or clinical features of parkinsonism in humans. We assessed lifetime use of pesticides selected by mechanism in a case-control study nested in the Agricultural Health Study (AHS). PD was diagnosed by movement disorders specialists. Controls were a stratified random sample of all AHS participants frequency-matched to cases by age, sex, and state at approximately three controls: one case. In 110 PD cases and 358 controls, PD was associated with use of a group of pesticides that inhibit mitochondrial complex I [odds ratio (OR) = 1.7; 95% confidence interval (CI), 1.0-2.8] including rotenone (OR = 2.5; 95% CI, 1.3-4.7) and with use of a group of pesticides that cause oxidative stress (OR = 2.0; 95% CI, 1.2-3.6), including paraquat (OR = 2.5; 95% CI, 1.4-4.7). PD was positively associated with two groups of pesticides defined by mechanisms implicated experimentally-those that impair mitochondrial function and those that increase oxidative stress-supporting a role for these mechanisms in PD pathophysiology. JF - Environmental Health Perspectives AU - Tanner, Caroline M AU - Kamel, Freya AU - Ross, GWebster AU - Hoppin, Jane A AU - Goldman, Samuel M AU - Korell, Monica AU - Marras, Connie AU - Bhudhikanok, Grace S AU - Kasten, Meike AU - Chade, Anabel R AU - Comyns, Kathleen AU - Richards, Marie Barber AU - Meng, Cheryl AU - Priestley, Benjamin AU - Fernandez, Hubert H AU - Cambi, Franca AU - Umbach, David M AU - Blair, Aaron AU - Sandler, Dale P AU - Langston, JWilliam AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2011/01/26/ PY - 2011 DA - 2011 Jan 26 SP - 866 EP - 872 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 119 IS - 6 SN - 0091-6765, 0091-6765 KW - CSA Neurosciences Abstracts; Environment Abstracts KW - aging KW - agricultural epidemiology KW - environmental epidemiology KW - epidemiology KW - fungicides KW - herbicides KW - insecticides KW - persistent organic pollutants KW - pesticides KW - Age KW - Parkinson's disease KW - Mitochondria KW - oxidative stress KW - Models KW - Neurodegenerative diseases KW - Movement disorders KW - Rotenone KW - Oxidative stress KW - Central nervous system diseases KW - Pesticides KW - NADH-ubiquinone oxidoreductase KW - Basal ganglia KW - Paraquat KW - Sex KW - ENA 06:Food & Drugs KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896222628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Rotenone%2C+Paraquat%2C+and+Parkinson%27s+Disease&rft.au=Tanner%2C+Caroline+M%3BKamel%2C+Freya%3BRoss%2C+GWebster%3BHoppin%2C+Jane+A%3BGoldman%2C+Samuel+M%3BKorell%2C+Monica%3BMarras%2C+Connie%3BBhudhikanok%2C+Grace+S%3BKasten%2C+Meike%3BChade%2C+Anabel+R%3BComyns%2C+Kathleen%3BRichards%2C+Marie+Barber%3BMeng%2C+Cheryl%3BPriestley%2C+Benjamin%3BFernandez%2C+Hubert+H%3BCambi%2C+Franca%3BUmbach%2C+David+M%3BBlair%2C+Aaron%3BSandler%2C+Dale+P%3BLangston%2C+JWilliam&rft.aulast=Tanner&rft.aufirst=Caroline&rft.date=2011-01-26&rft.volume=119&rft.issue=6&rft.spage=866&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002839 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Age; Parkinson's disease; Mitochondria; Models; Neurodegenerative diseases; Movement disorders; Rotenone; Oxidative stress; Pesticides; Central nervous system diseases; NADH-ubiquinone oxidoreductase; Paraquat; Basal ganglia; Sex; oxidative stress DO - http://dx.doi.org/10.1289/ehp.1002839 ER - TY - JOUR T1 - The Role of Research in Viral Disease Eradication and Elimination Programs: Lessons for Malaria Eradication AN - 902361146; 14389562 AB - Using their experiences from, and analysis of, global campaigns to eradicate smallpox, poliomyelitis, and measles, Myron Levine and colleagues derive lessons for malaria eradication. By examining the role research has played in eradication or regional elimination initiatives for three viral diseases--smallpox, poliomyelitis, and measles--we derive nine cross-cutting lessons applicable to malaria eradication. In these initiatives, some types of research commenced as the programs began and proceeded in parallel. Basic laboratory, clinical, and field research all contributed notably to progress made in the viral programs. For each program, vaccine was the lynchpin intervention, but as the programs progressed, research was required to improve vaccine formulations, delivery methods, and immunization schedules. Surveillance was fundamental to all three programs, whilst polio eradication also required improved diagnostic methods to identify asymptomatic infections. Molecular characterization of pathogen isolates strengthened surveillance and allowed insights into the geographic source of infections and their spread. Anthropologic, sociologic, and behavioural research were needed to address cultural and religious beliefs to expand community acceptance. The last phases of elimination and eradication became increasingly difficult, as a nil incidence was approached. Any eradication initiative for malaria must incorporate flexible research agendas that can adapt to changing epidemiologic contingencies and allow planning for posteradication scenarios. JF - PLOS Medicine AU - Breman, Joel G AU - de Quadros, Ciro A AU - Dowdle, Walter R AU - Foege, William H AU - Henderson, Donald A AU - John, TJacob AU - Levine, Myron M AD - Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2011/01/25/ PY - 2011 DA - 2011 Jan 25 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 USA VL - 8 IS - 1 SN - 1549-1277, 1549-1277 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; Virology & AIDS Abstracts KW - Biological surveys KW - Poliovirus KW - Human diseases KW - Sociological aspects KW - Measles KW - Disease control KW - Asymptomatic infection KW - Malaria KW - Pathogens KW - Immunization KW - Public health KW - Disease transmission KW - Smallpox KW - Viral diseases KW - Poliomyelitis KW - Vaccines KW - Contingency KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902361146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLOS+Medicine&rft.atitle=The+Role+of+Research+in+Viral+Disease+Eradication+and+Elimination+Programs%3A+Lessons+for+Malaria+Eradication&rft.au=Breman%2C+Joel+G%3Bde+Quadros%2C+Ciro+A%3BDowdle%2C+Walter+R%3BFoege%2C+William+H%3BHenderson%2C+Donald+A%3BJohn%2C+TJacob%3BLevine%2C+Myron+M&rft.aulast=Breman&rft.aufirst=Joel&rft.date=2011-01-25&rft.volume=8&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLOS+Medicine&rft.issn=15491277&rft_id=info:doi/10.1371%2Fjournal.pmed.1000405 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Biological surveys; Human diseases; Sociological aspects; Viral diseases; Disease control; Malaria; Vaccines; Disease transmission; Public health; Smallpox; Measles; Poliomyelitis; Asymptomatic infection; Pathogens; Immunization; Contingency; Poliovirus DO - http://dx.doi.org/10.1371/journal.pmed.1000405 ER - TY - JOUR T1 - Phase I trial of lenalidomide in pediatric patients with recurrent, refractory, or progressive primary CNS tumors: Pediatric Brain Tumor Consortium study PBTC-018. AN - 845764674; 21149652 AB - A phase I trial of lenalidomide was performed in children with recurrent, refractory, or progressive primary CNS tumors to estimate the maximum-tolerated dose (MTD) and to describe the toxicity profile and pharmacokinetics. Lenalidomide was administered by mouth daily for 21 days, repeated every 28 days. The starting dose was 15 mg/m(2)/d orally, and the dose was escalated according to a modified continuous reassessment method. Correlative studies included pharmacokinetics obtained from consenting patients on course 1, day 1, and at steady-state (between days 7 and 21). Fifty-one patients (median age, 10 years; range, 2 to 21 years) were enrolled. Forty-four patients were evaluable for dose finding, and 49 patients were evaluable for toxicity. The primary toxicity was myelosuppression, but the MTD was not defined because doses up to 116 mg/m(2)/d were well-tolerated during the dose-finding period. Two objective responses were observed (one in thalamic juvenile pilocytic astrocytoma and one in optic pathway glioma) at dose levels of 88 and 116 mg/m(2)/d. Twenty-three patients, representing all dose levels, received ≥ six cycles of therapy. Pharmacokinetic analysis demonstrated that the lenalidomide area under the concentration-time curve from 0 to 24 hours and maximum plasma concentration increased with dosage over the range studied. Lenalidomide was tolerable in children with CNS tumors at doses of 116 mg/m(2)/d during the initial dose-finding period. The primary toxicity is myelosuppression. Antitumor activity, defined by both objective responses and long-term stable disease, was observed, primarily in patients with low-grade gliomas. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Warren, Katherine E AU - Goldman, Stewart AU - Pollack, Ian F AU - Fangusaro, Jason AU - Schaiquevich, Paula AU - Stewart, Clinton F AU - Wallace, Dana AU - Blaney, Susan M AU - Packer, Roger AU - Macdonald, Tobey AU - Jakacki, Regina AU - Boyett, James M AU - Kun, Larry E AD - National Cancer Institute, Pediatric Oncology Branch, Bldg 10 CRC, Rm 1-5750, Bethesda, MD 20892-1104, USA. warrenk@mail.nih.gov Y1 - 2011/01/20/ PY - 2011 DA - 2011 Jan 20 SP - 324 EP - 329 VL - 29 IS - 3 KW - Antineoplastic Agents KW - 0 KW - Thalidomide KW - 4Z8R6ORS6L KW - lenalidomide KW - F0P408N6V4 KW - Index Medicus KW - Administration, Oral KW - Young Adult KW - Drug Administration Schedule KW - Area Under Curve KW - Dose-Response Relationship, Drug KW - Humans KW - Child KW - Maximum Tolerated Dose KW - Adolescent KW - Recurrence KW - Male KW - Female KW - Child, Preschool KW - Thalidomide -- pharmacokinetics KW - Thalidomide -- adverse effects KW - Antineoplastic Agents -- administration & dosage KW - Antineoplastic Agents -- pharmacokinetics KW - Central Nervous System Neoplasms -- drug therapy KW - Thalidomide -- administration & dosage KW - Thalidomide -- pharmacology KW - Antineoplastic Agents -- pharmacology KW - Thalidomide -- analogs & derivatives KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/845764674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Phase+I+trial+of+lenalidomide+in+pediatric+patients+with+recurrent%2C+refractory%2C+or+progressive+primary+CNS+tumors%3A+Pediatric+Brain+Tumor+Consortium+study+PBTC-018.&rft.au=Warren%2C+Katherine+E%3BGoldman%2C+Stewart%3BPollack%2C+Ian+F%3BFangusaro%2C+Jason%3BSchaiquevich%2C+Paula%3BStewart%2C+Clinton+F%3BWallace%2C+Dana%3BBlaney%2C+Susan+M%3BPacker%2C+Roger%3BMacdonald%2C+Tobey%3BJakacki%2C+Regina%3BBoyett%2C+James+M%3BKun%2C+Larry+E&rft.aulast=Warren&rft.aufirst=Katherine&rft.date=2011-01-20&rft.volume=29&rft.issue=3&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2010.31.3601 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-22 N1 - Date created - 2011-01-19 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Blood. 2002 Nov 1;100(9):3063-7 [12384400] Blood. 2004 Mar 1;103(5):1787-90 [14512311] Br J Cancer. 2004 Mar 8;90(5):955-61 [14997189] Cancer Chemother Pharmacol. 1998;41(6):429-36 [9554585] J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Nov 25;811(2):135-41 [15522712] Br J Haematol. 2005 Jan;128(2):192-203 [15638853] Semin Hematol. 2005 Oct;42(4 Suppl 4):S3-8 [16344099] Future Oncol. 2005 Oct;1(5):575-83 [16556034] N Engl J Med. 2006 May 11;354(19):2079-80 [16687729] Eur J Cancer. 2006 Sep;42(14):2318-25 [16899362] N Engl J Med. 2006 Oct 5;355(14):1456-65 [17021321] Cancer. 2006 Dec 1;107(11):2609-16 [17075879] Gynecol Oncol. 2007 Apr;105(1):194-8 [17257661] J Thorac Oncol. 2007 May;2(5):445-9 [17473661] Cancer. 2007 Oct 1;110(7):1542-50 [17705175] Hematol Oncol Clin North Am. 2007 Dec;21(6):1071-91, viii-ix [17996589] Clin Cancer Res. 2007 Dec 1;13(23):7101-6 [18056189] Invest New Drugs. 2008 Jun;26(3):273-6 [18161005] Am J Clin Oncol. 2008 Jun;31(3):244-9 [18525302] Leuk Lymphoma. 2008 Jul;49(7):1238-45 [18452080] Cancer Immunol Immunother. 2008 Dec;57(12):1849-59 [18392823] J Clin Oncol. 2008 Oct 20;26(30):4952-7 [18606983] Microvasc Res. 2009 Mar;77(2):78-86 [18805433] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1200/JCO.2010.31.3601 ER - TY - JOUR T1 - HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration AN - 907150797; 14266528 AB - What drives the gradual degeneration of dopamine neurons in Parkinson's disease (PD), the second most common neurodegenerative disease, remains elusive. Here, we demonstrated, for the first time, that persistent neuroinflammation was indispensible for such a neurodegenerative process. 1-Methyl-4-phenylpyridinium, lipopolysaccharide (LPS), and rotenone, three toxins often used to create PD models, produced acute but nonprogressive neurotoxicity in neuron-enriched cultures. In the presence of microglia (brain immune cells), these toxins induced progressive dopaminergic neurodegeneration. More importantly, such neurodegeneration was prevented by removing activated microglia. Collectively, chronic neuroinflammation may be a driving force of progressive dopaminergic neurodegeneration. Conversely, ongoing neurodegeneration sustained microglial activation. Microglial activation persisted only in the presence of neuronal damage in LPS-treated neuron-glia cultures but not in LPS-treated mixed-glia cultures. Thus, activated microglia and damaged neurons formed a vicious cycle mediating chronic, progressive neurodegeneration. Mechanistic studies indicated that HMGB1 (high-mobility group box 1), released from inflamed microglia and/or degenerating neurons, bound to microglial Mac1 (macrophage antigen complex 1) and activated nuclear factor- Kappa B pathway and NADPH oxidase to stimulate production of multiple inflammatory and neurotoxic factors. The treatment of microglia with HMGB1 led to membrane translocation of p47phox (a cytosolic subunit of NADPH oxidase) and consequent superoxide release, which required the presence of Mac1. Neutralization of HMGB1 and genetic ablation of Mac1 and gp91phox (the catalytic submit of NADPH oxidase) blocked the progressive neurodegeneration. Our findings indicated that HMGB1-Mac1-NADPH oxidase signaling axis bridged chronic neuroinflammation and progressive dopaminergic neurodegeneration, thus identifying a mechanistic basis for chronic PD progression. JF - Journal of Neuroscience AU - Gao, Hui-Ming AU - Zhou, Hui AU - Zhang, Feng AU - Wilson, Belinda C AU - Kam, Wayneho AU - Hong, Jau-Shyong AD - Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina 27709 Y1 - 2011/01/19/ PY - 2011 DA - 2011 Jan 19 SP - 1081 EP - 1092 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Washington DC 20036 USA VL - 31 IS - 3 SN - 0270-6474, 0270-6474 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Macrophages KW - HMGB1 protein KW - Parkinson's disease KW - Brain KW - Cell culture KW - Microglia KW - Neurodegeneration KW - Toxins KW - Inflammation KW - Neurodegenerative diseases KW - Nervous system KW - Dopamine KW - Movement disorders KW - Rotenone KW - Superoxide KW - Neurotoxicity KW - Lipopolysaccharides KW - NAD(P)H oxidase KW - Signal transduction KW - X 24370:Natural Toxins KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907150797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=HMGB1+Acts+on+Microglia+Mac1+to+Mediate+Chronic+Neuroinflammation+That+Drives+Progressive+Neurodegeneration&rft.au=Gao%2C+Hui-Ming%3BZhou%2C+Hui%3BZhang%2C+Feng%3BWilson%2C+Belinda+C%3BKam%2C+Wayneho%3BHong%2C+Jau-Shyong&rft.aulast=Gao&rft.aufirst=Hui-Ming&rft.date=2011-01-19&rft.volume=31&rft.issue=3&rft.spage=1081&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Macrophages; HMGB1 protein; Parkinson's disease; Brain; Cell culture; Microglia; Neurodegeneration; Toxins; Inflammation; Neurodegenerative diseases; Nervous system; Movement disorders; Dopamine; Rotenone; Superoxide; Neurotoxicity; Lipopolysaccharides; NAD(P)H oxidase; Signal transduction ER - TY - JOUR T1 - Inference From a Multiplicative Model of Joint Genetic Effects or Ovarian Cancer Risk AN - 904465117; 14266487 JF - Journal of the National Cancer Institute AU - Wacholder, Sholom AU - Han, Summer S AU - Weinberg, Clarice R AD - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SW, SSH) Y1 - 2011/01/19/ PY - 2011 DA - 2011 Jan 19 SP - 82 EP - 83 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 103 IS - 2 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - ovarian carcinoma KW - genetic effects KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904465117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Inference+From+a+Multiplicative+Model+of+Joint+Genetic+Effects+or+Ovarian+Cancer+Risk&rft.au=Wacholder%2C+Sholom%3BHan%2C+Summer+S%3BWeinberg%2C+Clarice+R&rft.aulast=Wacholder&rft.aufirst=Sholom&rft.date=2011-01-19&rft.volume=103&rft.issue=2&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - genetic effects; ovarian carcinoma; Cancer ER - TY - JOUR T1 - Genetic susceptibility to systemic lupus erythematosus protects against cerebral malaria in mice AN - 907153598; 14266849 AB - Plasmodium falciparum has exerted tremendous selective pressure on genes that improve survival in severe malarial infections. Systemic lupus erythematosus (SLE) is an autoimmune disease that is six to eight times more prevalent in women of African descent than in women of European descent. Here we provide evidence that a genetic susceptibility to SLE protects against cerebral malaria. Mice that are prone to SLE because of a deficiency in Fc gamma RIIB or overexpression of Toll-like receptor 7 are protected from death caused by cerebral malaria. Protection appears to be by immune mechanisms that allow SLE-prone mice better to control their overall inflammatory responses to parasite infections. These findings suggest that the high prevalence of SLE in women of African descent living outside of Africa may result from the inheritance of genes that are beneficial in the immune control of cerebral malaria but that, in the absence of malaria, contribute to autoimmune disease. JF - Proceedings of the National Academy of Sciences, USA AU - Waisberg, Michael AU - Tarasenko, Tatyana AU - Vickers, Brandi K AU - Scott, Bethany L AU - Willcocks, Lisa C AU - Molina-Cruz, Alvaro AU - Pierce, Matthew A AU - Huang, Chiung-yu AU - Torres-Velez, Fernando J AU - Smith, Kenneth GC AU - Barillas-Mury, Carolina AU - Miller, Louis H AU - Pierce, Susan K AU - Bolland, Silvia AD - Laboratories of Immunogenetics and Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 Y1 - 2011/01/18/ PY - 2011 DA - 2011 Jan 18 SP - 1122 EP - 1127 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 108 IS - 3 SN - 0027-8424, 0027-8424 KW - Genetics Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; CSA Neurosciences Abstracts KW - Parasites KW - Human diseases KW - Heredity KW - Autoimmune diseases KW - Receptors KW - Disease control KW - Survival KW - Malaria KW - Plasmodium falciparum KW - Infection KW - Inflammation KW - Public health KW - Systemic lupus erythematosus KW - Toll-like receptors KW - G 07720:Immunogenetics KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907153598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Genetic+susceptibility+to+systemic+lupus+erythematosus+protects+against+cerebral+malaria+in+mice&rft.au=Waisberg%2C+Michael%3BTarasenko%2C+Tatyana%3BVickers%2C+Brandi+K%3BScott%2C+Bethany+L%3BWillcocks%2C+Lisa+C%3BMolina-Cruz%2C+Alvaro%3BPierce%2C+Matthew+A%3BHuang%2C+Chiung-yu%3BTorres-Velez%2C+Fernando+J%3BSmith%2C+Kenneth+GC%3BBarillas-Mury%2C+Carolina%3BMiller%2C+Louis+H%3BPierce%2C+Susan+K%3BBolland%2C+Silvia&rft.aulast=Waisberg&rft.aufirst=Michael&rft.date=2011-01-18&rft.volume=108&rft.issue=3&rft.spage=1122&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Disease control; Receptors; Malaria; Public health; Heredity; Autoimmune diseases; Survival; Systemic lupus erythematosus; Infection; Toll-like receptors; Inflammation; Plasmodium falciparum ER - TY - JOUR T1 - Neuromuscular junction toxicity with tandutinib induces a myasthenic-like syndrome. AN - 845398436; 21242491 AB - Tandutinib (MLN 518, Millennium Pharmaceuticals, Cambridge, MA) is an orally active multitargeted tyrosine kinase inhibitor that is currently under evaluation for the treatment of glioblastoma and has been used in the treatment of leukemia. In prior clinical and animal studies, a dose-dependent muscular weakness has been observed with this drug, though the etiology of the weakness has not been defined. Standard neurophysiologic techniques, including repetitive nerve stimulation, needle EMG, and single-fiber EMG, were used to evaluate patients who developed weakness while being treated with tandutinib and bevacizumab (Avastin, Genentech, South San Francisco, CA) for glioblastoma (NCT00667394). Six patients were observed to develop a reversible weakness that correlated with the administration of the tandutinib. The onset of weakness after starting tandutinib occurred within 3 to 112 days and in less than 15 days in 3 patients. Electrophysiologic studies showed that all patients developed abnormal repetitive nerve stimulation studies. Four patients had short duration motor unit potentials. Two of these patients also had abnormal single-fiber EMG, as did a third patient who did not have standard needle EMG. The clinical and electrophysiologic abnormalities improved with the termination or reduction in the dose of tandutinib. These observations suggest that tandutinib is toxic to the neuromuscular junction, possibly by reversibly binding to a molecule on the postsynaptic acetylcholine receptor complex. This study provides Class III evidence that tandutinib 500 mg twice daily induces reversible muscle weakness and electrophysiologic changes consistent with neuromuscular junction dysfunction. JF - Neurology AU - Lehky, T J AU - Iwamoto, F M AU - Kreisl, T N AU - Floeter, M K AU - Fine, H A AD - EMG Section, NINDS, NIH, 8900 Wisconsin Ave., Bethesda, MD 20892-1404, USA. lehkyt@ninds.nih.gov Y1 - 2011/01/18/ PY - 2011 DA - 2011 Jan 18 SP - 236 EP - 241 VL - 76 IS - 3 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Piperazines KW - Protein Kinase Inhibitors KW - Quinazolines KW - Bevacizumab KW - 2S9ZZM9Q9V KW - tandutinib KW - E1IO3ICJ9A KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Abridged Index Medicus KW - Index Medicus KW - Neuromuscular Diseases -- chemically induced KW - Drug Administration Schedule KW - Clinical Trials, Phase II as Topic KW - Humans KW - Electromyography KW - Aged KW - Glioblastoma -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antibodies, Monoclonal -- administration & dosage KW - Brain Neoplasms -- drug therapy KW - Syndrome KW - Adult KW - Middle Aged KW - Male KW - Female KW - Quinazolines -- administration & dosage KW - Protein-Tyrosine Kinases -- antagonists & inhibitors KW - Neuromuscular Junction -- drug effects KW - Myasthenia Gravis -- physiopathology KW - Protein Kinase Inhibitors -- adverse effects KW - Protein Kinase Inhibitors -- administration & dosage KW - Myasthenia Gravis -- chemically induced KW - Quinazolines -- adverse effects KW - Piperazines -- adverse effects KW - Piperazines -- administration & dosage KW - Neuromuscular Junction -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/845398436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Neuromuscular+junction+toxicity+with+tandutinib+induces+a+myasthenic-like+syndrome.&rft.au=Lehky%2C+T+J%3BIwamoto%2C+F+M%3BKreisl%2C+T+N%3BFloeter%2C+M+K%3BFine%2C+H+A&rft.aulast=Lehky&rft.aufirst=T&rft.date=2011-01-18&rft.volume=76&rft.issue=3&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=1526-632X&rft_id=info:doi/10.1212%2FWNL.0b013e3182074a69 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-14 N1 - Date created - 2011-01-18 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00667394; ClinicalTrials.gov N1 - SuppNotes - Cited By: IDrugs. 2008 Jan;11(1):46-56 [18175263] Clin Lymphoma Myeloma. 2007 Dec;8 Suppl 1:S24-34 [18282363] Eur J Pharmacol. 2008 Dec 3;599(1-3):44-53 [18938156] J Clin Oncol. 2009 Feb 10;27(5):740-5 [19114704] J Neurooncol. 2010 Feb;96(3):349-57 [19629393] Blood. 2006 Dec 1;108(12):3674-81 [16902153] Muscle Nerve. 2002 Jan;25(1):4-16 [11754179] J Clin Invest. 2003 May;111(9):1287-95 [12727920] Ann N Y Acad Sci. 1998 May 13;841:433-49 [9668273] Cancer Cell. 2006 Apr;9(4):287-300 [16616334] Brain. 2006 Jun;129(Pt 6):1481-92 [16672291] Tohoku J Exp Med. 1999 Dec;189(4):239-44 [10739160] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1212/WNL.0b013e3182074a69 ER - TY - JOUR T1 - Impairment of prosocial sentiments is associated with frontopolar and septal damage in frontotemporal dementia AN - 954615676; 14252575 AB - Poets and philosophers have long acknowledged moral sentiments as key motivators of human social behavior. Prosocial sentiments, which include guilt, pity and embarrassment, enable us to care about others and to be concerned about our mistakes. Functional imaging studies have implicated frontopolar, ventromedial frontal and basal forebrain regions in the experience of prosocial sentiments. Patients with lesions of the frontopolar and ventromedial frontal areas were observed to behave inappropriately and less prosocially, which could be attributed to a generalized emotional blunting. Direct experimental evidence for brain regions distinctively associated with moral sentiment impairments is lacking, however. We investigated this issue in patients with the behavioral variant of frontotemporal dementia, a disorder in which early and selective impairments of social conduct are consistently observed. Using a novel moral sentiment task, we show that the degree of impairment of prosocial sentiments is associated with the degree of damage to frontopolar cortex and septal area, as assessed with 18-Fluoro-Deoxy-Glucose-Positron Emission Tomography, an established measure of neurodegenerative damage. This effect was dissociable from impairment of other-critical feelings (anger and disgust), which was in turn associated with dorsomedial prefrontal and amygdala dysfunction. Our findings suggest a critical role of the frontopolar cortex and septal region in enabling prosocial sentiments, a fundamental component of moral conscience. JF - NeuroImage AU - Moll, Jorge AU - Zahn, Roland AU - De Oliveira-Souza, Ricardo AU - Bramati, Ivanei E AU - Krueger, Frank AU - Tura, Bernardo AU - Cavanagh, Alyson L AU - Grafman, Jordan AD - Cognitive Neuroscience Section, NINDS, National Institutes of Health, Bethesda, MD, USA, grafmanj@ninds.nih.gov Y1 - 2011/01/15/ PY - 2011 DA - 2011 Jan 15 SP - 1735 EP - 1742 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 54 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Amygdala KW - Ethics KW - W 30910:Imaging KW - N3:11001 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954615676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Impairment+of+prosocial+sentiments+is+associated+with+frontopolar+and+septal+damage+in+frontotemporal+dementia&rft.au=Moll%2C+Jorge%3BZahn%2C+Roland%3BDe+Oliveira-Souza%2C+Ricardo%3BBramati%2C+Ivanei+E%3BKrueger%2C+Frank%3BTura%2C+Bernardo%3BCavanagh%2C+Alyson+L%3BGrafman%2C+Jordan&rft.aulast=Moll&rft.aufirst=Jorge&rft.date=2011-01-15&rft.volume=54&rft.issue=2&rft.spage=1735&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.08.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Ethics DO - http://dx.doi.org/10.1016/j.neuroimage.2010.08.026 ER - TY - JOUR T1 - NCI Image-Guided Drug Delivery Summit AN - 907149549; 14219838 AB - On April 17, 2010, scientists from academia, the National Cancer Institute (NCI), and the Food and Drug Administration (FDA) assembled at "The NCI Image Guided Drug Delivery Summit," in Washington D.C., to discuss recent advances, barriers, opportunities, and regulatory issues related to the field. The meeting included a scientific session and an NCI/FDA session, followed by a panel discussion of speakers from both sessions. Image-guided drug delivery (IGDD) in cancer is a form of individualized therapy where imaging methods are used in guidance and monitoring of localized and targeted delivery of therapeutics to the tumor. So, a systematic approach to IGDD requires mechanisms for targeting, delivery, activation, and monitoring of the process. Although the goal in IGDD is to optimize the therapeutic ratio through personalized image-guided treatments, a major challenge is in overcoming the biological barriers to the delivery of therapeutics into tumors and cells. Speakers discussed potential challenges to clinical translation of nano-based drug delivery systems including in vivo characterization of nanocarriers, preclinical validation of targeting and delivery, studies of biodistribution, pharmacokinetics, pharmacodynamics, and toxicity as well as scale-up manufacturing of delivery systems. Physiologic and quantitative imaging techniques may serve as enabling tools that could potentially transform many existing challenges into opportunities for advancement of the field. Cancer Res; 71(2); 314-7. [copy ]2011 AACR. JF - Cancer Research AU - Tandon, Pushpa AU - Farahani, Keyvan AD - Authors' Affiliation: Cancer Imaging Program, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2011/01/15/ PY - 2011 DA - 2011 Jan 15 SP - 314 EP - 317 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 71 IS - 2 SN - 0008-5472, 0008-5472 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Translation KW - Tumors KW - Toxicity KW - imaging KW - Cancer KW - Pharmacokinetics KW - Pharmacodynamics KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907149549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=NCI+Image-Guided+Drug+Delivery+Summit&rft.au=Tandon%2C+Pushpa%3BFarahani%2C+Keyvan&rft.aulast=Tandon&rft.aufirst=Pushpa&rft.date=2011-01-15&rft.volume=71&rft.issue=2&rft.spage=314&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Translation; Drug delivery; Toxicity; Tumors; imaging; Pharmacodynamics; Pharmacokinetics; Cancer ER - TY - JOUR T1 - Lactobacillus-Mediated Priming of the Respiratory Mucosa Protects against Lethal Pneumovirus Infection AN - 904463493; 14212413 AB - The inflammatory response to respiratory virus infection can be complex and refractory to standard therapy. Lactobacilli, when targeted to the respiratory epithelium, are highly effective at suppressing virus-induced inflammation and protecting against lethal disease. Specifically, wild-type mice primed via intranasal inoculation with live or heat-inactivated Lactobacillus plantarum or Lactobacillus reuteri were completely protected against lethal infection with the virulent rodent pathogen, pneumonia virus of mice; significant protection (60% survival) persisted for at least 13 wk. Protection was not unique to Lactobacillus species, and it was also observed in response to priming with nonpathogenic Gram-positive Listeria innocua. Priming with live lactobacilli resulted in diminished granulocyte recruitment, diminished expression of multiple proinflammatory cytokines (CXCL10, CXCL1, CCL2, and TNF), and reduced virus recovery, although we have demonstrated clearly that absolute virus titer does not predict clinical outcome. Lactobacillus priming also resulted in prolonged survival and protection against the lethal sequelae of pneumonia virus of mice infection in MyD88 gene-deleted (MyD88-/-) mice, suggesting that the protective mechanisms may be TLR-independent. Most intriguing, virus recovery and cytokine expression patterns in Lactobacillus-primed MyD88-/- mice were indistinguishable from those observed in control-primed MyD88-/- counterparts. In summary, we have identified and characterized an effective Lactobacillus-mediated innate immune shield, which may ultimately serve as critical and long-term protection against infection in the absence of specific antiviral vaccines. JF - Journal of Immunology AU - Gabryszewski, Stanislaw J AU - Bachar, Ofir AU - Dyer, Kimberly D AU - Percopo, Caroline M AU - Killoran, Kristin E AU - Domachowske, Joseph B AU - Rosenberg, Helene F AD - Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2011/01/15/ PY - 2011 DA - 2011 Jan 15 SP - 1151 EP - 1161 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA VL - 186 IS - 2 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Plant protection KW - Lactobacillus plantarum KW - Tumor necrosis factor KW - Listeria innocua KW - Mucosa KW - Survival KW - Infection KW - Lactobacillus KW - Lactobacillus reuteri KW - Cytokines KW - Pneumonia virus of mice KW - Respiratory tract KW - Pneumovirus KW - Monocyte chemoattractant protein 1 KW - Complications KW - MyD88 protein KW - Recruitment KW - Pathogens KW - Inflammation KW - CXCL10 protein KW - Leukocytes (granulocytic) KW - Inoculation KW - Vaccines KW - Pneumonia KW - F 06905:Vaccines KW - V 22350:Immunology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904463493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Lactobacillus-Mediated+Priming+of+the+Respiratory+Mucosa+Protects+against+Lethal+Pneumovirus+Infection&rft.au=Gabryszewski%2C+Stanislaw+J%3BBachar%2C+Ofir%3BDyer%2C+Kimberly+D%3BPercopo%2C+Caroline+M%3BKilloran%2C+Kristin+E%3BDomachowske%2C+Joseph+B%3BRosenberg%2C+Helene+F&rft.aulast=Gabryszewski&rft.aufirst=Stanislaw&rft.date=2011-01-15&rft.volume=186&rft.issue=2&rft.spage=1151&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Monocyte chemoattractant protein 1; MyD88 protein; Plant protection; Complications; Tumor necrosis factor; Mucosa; Recruitment; Survival; Pathogens; Infection; Inflammation; CXCL10 protein; Leukocytes (granulocytic); Inoculation; Cytokines; Vaccines; Pneumonia; Respiratory tract; Pneumovirus; Lactobacillus reuteri; Lactobacillus; Lactobacillus plantarum; Listeria innocua; Pneumonia virus of mice ER - TY - JOUR T1 - Identifying cancer driver genes in tumor genome sequencing studies AN - 861538552; 14209977 AB - Motivation: Major tumor sequencing projects have been conducted in the past few years to identify genes that contain 'driver' somatic mutations in tumor samples. These genes have been defined as those for which the non-silent mutation rate is significantly greater than a background mutation rate estimated from silent mutations. Several methods have been used for estimating the background mutation rate.Results: We propose a new method for identifying cancer driver genes, which we believe provides improved accuracy. The new method accounts for the functional impact of mutations on proteins, variation in background mutation rate among tumors and the redundancy of the genetic code. We reanalyzed sequence data for 623 candidate genes in 188 non-small cell lung tumors using the new method. We found several important genes like PTEN, which were not deemed significant by the previous method. At the same time, we determined that some genes previously reported as drivers were not significant by the new analysis because mutations in these genes occurred mainly in tumors with large background mutation rates. JF - Bioinformatics AU - Youn, Ahrim AU - Simon, Richard AD - Biometric Research Branch, National Cancer Institute, 9000 Rockville Pike, MSC 7434, Bethesda MD 20892-7434, USA Y1 - 2011/01/15/ PY - 2011 DA - 2011 Jan 15 SP - 175 EP - 181 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 27 IS - 2 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Data processing KW - Tumors KW - PTEN protein KW - Mutation rates KW - Cancer KW - Computer programs KW - software KW - Lung KW - Bioinformatics KW - Internet KW - Genetic code KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/861538552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Identifying+cancer+driver+genes+in+tumor+genome+sequencing+studies&rft.au=Youn%2C+Ahrim%3BSimon%2C+Richard&rft.aulast=Youn&rft.aufirst=Ahrim&rft.date=2011-01-15&rft.volume=27&rft.issue=2&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtq630 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Genomes; Computer programs; software; Data processing; Lung; PTEN protein; Bioinformatics; Tumors; Mutation rates; Internet; Cancer; Genetic code DO - http://dx.doi.org/10.1093/bioinformatics/btq630 ER - TY - JOUR T1 - Predicting in vitro drug sensitivity using Random Forests AN - 861537583; 14209978 AB - Motivation: Panels of cell lines such as the NCI-60 have long been used to test drug candidates for their ability to inhibit proliferation. Predictive models of in vitro drug sensitivity have previously been constructed using gene expression signatures generated from gene expression microarrays. These statistical models allow the prediction of drug response for cell lines not in the original NCI-60. We improve on existing techniques by developing a novel multistep algorithm that builds regression models of drug response using Random Forest, an ensemble approach based on classification and regression trees (CART).Results: This method proved successful in predicting drug response for both a panel of 19 Breast Cancer and 7 Glioma cell lines, outperformed other methods based on differential gene expression, and has general utility for any application that seeks to relate gene expression data to a continuous output variable.Implementation: Software was written in the R language and will be available together with associated gene expression and drug response data as the package ivDrug at http://r-forge.r-project.org. JF - Bioinformatics AU - Riddick, Gregory AU - Song, Hua AU - Ahn, Susie AU - Walling, Jennifer AU - Borges-Rivera, Diego AU - Zhang, Wei AU - Fine, Howard A AD - super(1)Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD and super(2)Carnegie-Mellon University, Pittsburgh, PA, USA Y1 - 2011/01/15/ PY - 2011 DA - 2011 Jan 15 SP - 220 EP - 224 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 27 IS - 2 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Mathematical models KW - Algorithms KW - Statistical analysis KW - Forests KW - Drug development KW - DNA microarrays KW - Gene expression KW - Computer programs KW - software KW - Glioma cells KW - Regression analysis KW - Breast cancer KW - Language KW - Bioinformatics KW - Drugs KW - Internet KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/861537583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Predicting+in+vitro+drug+sensitivity+using+Random+Forests&rft.au=Riddick%2C+Gregory%3BSong%2C+Hua%3BAhn%2C+Susie%3BWalling%2C+Jennifer%3BBorges-Rivera%2C+Diego%3BZhang%2C+Wei%3BFine%2C+Howard+A&rft.aulast=Riddick&rft.aufirst=Gregory&rft.date=2011-01-15&rft.volume=27&rft.issue=2&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtq628 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Mathematical models; Data processing; Statistical analysis; Algorithms; Forests; Drug development; DNA microarrays; Gene expression; Computer programs; software; Glioma cells; Regression analysis; Breast cancer; Language; Bioinformatics; Drugs; Internet DO - http://dx.doi.org/10.1093/bioinformatics/btq628 ER - TY - JOUR T1 - Promoter Discrimination at Class I MarA Regulon Promoters Mediated by Glutamic Acid 89 of the MarA Transcriptional Activator of Escherichia coli AN - 856775197; 14169613 AB - Three paralogous transcriptional activators MarA, SoxS, and Rob, activate >40 Escherichia coli promoters. To understand why MarA does not activate certain promoters as strongly as SoxS, we compared MarA, MarA mutants, and SoxS for their abilities to activate 16 promoters and to bind their cognate marbox binding sites. Replacement of the MarA glutamic acid residue 89 with alanine greatly increased the marbox binding and activation of many class I promoters. Like cells constitutive for SoxS, cells expressing the MarA with the E89A mutation were more resistant to superoxides than those harboring WT MarA. The activities of several other E89 substitutions ranked as follows: E89A > E89G > E89V > WT > E89D. Increased binding and activation occurred only at class I promoters when the 12th base of the promoter's marbox (a position at which there is no known interaction between the marbox and MarA) was not a T residue. Furthermore, WT MarA binding to a synthetic marbox in vitro was enhanced when the phosphate group between positions 12 and 13 was eliminated on one strand. The results demonstrate that relatively minor changes in a single amino acid side chain (e.g., alanine to valine or glutamic acid to aspartic acid) can strongly influence activity despite any evidence that the side chain is involved in positive interactions with either DNA or RNA polymerase. We present a model which attributes the differences in binding and activation to the interference between the beta - and gamma -carbons of the amino acid at position 89 and the phosphate group between positions 12 and 13. JF - Journal of Bacteriology AU - Martin, Robert G AU - Rosner, Judah L AD - Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0560 Y1 - 2011/01/15/ PY - 2011 DA - 2011 Jan 15 SP - 506 EP - 515 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 193 IS - 2 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Aspartic acid KW - Amino acids KW - SoxS protein KW - Alanine KW - Transcription KW - Promoters KW - DNA-directed RNA polymerase KW - Phosphate KW - Transcription factors KW - Superoxide KW - Escherichia coli KW - DNA KW - valine KW - Glutamic acid KW - Mutation KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856775197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Promoter+Discrimination+at+Class+I+MarA+Regulon+Promoters+Mediated+by+Glutamic+Acid+89+of+the+MarA+Transcriptional+Activator+of+Escherichia+coli&rft.au=Martin%2C+Robert+G%3BRosner%2C+Judah+L&rft.aulast=Martin&rft.aufirst=Robert&rft.date=2011-01-15&rft.volume=193&rft.issue=2&rft.spage=506&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - SoxS protein; Amino acids; Aspartic acid; Alanine; Transcription; Promoters; DNA-directed RNA polymerase; Phosphate; Superoxide; Transcription factors; DNA; Glutamic acid; valine; Mutation; Escherichia coli ER - TY - JOUR T1 - Effects of physiological noise in population analysis of diffusion tensor MRI data AN - 855721362; 14252554 AB - The goal of this study is to characterize the potential effect of artifacts originating from physiological noise on statistical analysis of diffusion tensor MRI (DTI) data in a population. DTI derived quantities including mean diffusivity (Trace(D)), fractional anisotropy (FA), and principal eigenvector ( epsilon sub(1)) are computed in the brain of 40 healthy subjects from tensors estimated using two different methods: conventional nonlinear least-squares, and robust fitting (RESTORE). RESTORE identifies artifactual data points as outliers and excludes them on a voxel-by-voxel basis. We found that outlier data points are localized in specific spatial clusters in the population, indicating a consistency in brain regions affected across subjects. In brain parenchyma RESTORE slightly reduces inter-subject variance of FA and Trace(D). The dominant effect of artifacts, however, is bias. Voxel-wise analysis indicates that inclusion of outlier data points results in clusters of under- and over-estimation of FA, while Trace(D) is always over-estimated. Removing outliers affects epsilon sub(1) mostly in low anisotropy regions. It was found that brain regions known to be affected by cardiac pulsation - cerebellum and genu of the corpus callosum, as well as regions not previously reported, splenium of the corpus callosum - show significant effects in the population analysis. It is generally assumed that statistical properties of DTI data are homogenous across the brain. This assumption does not appear to be valid based on these results. The use of RESTORE can lead to a more accurate evaluation of a population, and help reduce spurious findings that may occur due to artifacts in DTI data. JF - NeuroImage AU - Walker, Lindsay AU - Chang, Lin-Ching AU - Koay, Cheng Guan AU - Sharma, Nik AU - Cohen, Leonardo AU - Verma, Ragini AU - Pierpaoli, Carlo AD - Section on Tissue Biophysics and Biomimetics, Program on Pediatric Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA, walkerlin@mail.nih.gov Y1 - 2011/01/15/ PY - 2011 DA - 2011 Jan 15 SP - 1168 EP - 1177 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 54 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Parenchyma KW - Heart KW - Neuroimaging KW - Anisotropy KW - Statistics KW - Magnetic resonance imaging KW - Brain KW - Statistical analysis KW - Cerebellum KW - Noise KW - Corpus callosum KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855721362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Effects+of+physiological+noise+in+population+analysis+of+diffusion+tensor+MRI+data&rft.au=Walker%2C+Lindsay%3BChang%2C+Lin-Ching%3BKoay%2C+Cheng+Guan%3BSharma%2C+Nik%3BCohen%2C+Leonardo%3BVerma%2C+Ragini%3BPierpaoli%2C+Carlo&rft.aulast=Walker&rft.aufirst=Lindsay&rft.date=2011-01-15&rft.volume=54&rft.issue=2&rft.spage=1168&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.08.048 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Heart; Parenchyma; Neuroimaging; Statistics; Anisotropy; Magnetic resonance imaging; Noise; Cerebellum; Statistical analysis; Brain; Corpus callosum DO - http://dx.doi.org/10.1016/j.neuroimage.2010.08.048 ER - TY - JOUR T1 - Mapping plasticity in the forepaw digit barrel subfield of rat brains using functional MRI AN - 855721094; 14252549 AB - The topographic organization of the forepaw barrel subfield in layer IV of rat primary somatosensory cortex (S1) is a good model for studying neural function and plasticity. The goal of this study was to test the feasibility of functional MRI (fMRI) to map the forepaw digit representations in the S1 of the rat and its plasticity after digit amputation. Three dimensional echo-planar imaging with 300 micron isotropic resolution at 11.7T was used to achieve high signal-to-noise ratios and laminar layer resolution. By alternating electrical stimulation of the 2nd (D2) and 4th (D4) digits, functional activation in layer IV of the barrel subfields could be distinguished using a differential analysis. Furthermore, 2 and a half months after the amputation of the 3rd digit in baby rats, the overlapping area between D2 and D4 representations was increased. This indicates that the forepaw barrel subfield previously associated with the ablated digit is now associated with the representation of nearby digits, which is consistent with studies using electrophysiology and cytochrome oxidase staining. JF - NeuroImage AU - Weng, Jun-Cheng AU - Chuang, Kai-Hsiang AU - Goloshevsky, Artem AU - Dodd, Stephen J AU - Sharer, Kathryn AD - Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, chuang_kai_hsiang@sbic.a-star.edu.sg Y1 - 2011/01/15/ PY - 2011 DA - 2011 Jan 15 SP - 1122 EP - 1129 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 54 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Functional MRI KW - High resolution KW - Forepaw digit barrel subfield KW - Electrical stimulation KW - Brain mapping KW - Electrical stimuli KW - Neuroimaging KW - Amputation KW - Functional magnetic resonance imaging KW - Plasticity (neural) KW - Cytochrome-c oxidase KW - Electrophysiology KW - Mapping KW - Cortex (somatosensory) KW - Plasticity (functional) KW - W 30910:Imaging KW - N3 11006:Neuroanatomy, histology & cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855721094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Mapping+plasticity+in+the+forepaw+digit+barrel+subfield+of+rat+brains+using+functional+MRI&rft.au=Weng%2C+Jun-Cheng%3BChuang%2C+Kai-Hsiang%3BGoloshevsky%2C+Artem%3BDodd%2C+Stephen+J%3BSharer%2C+Kathryn&rft.aulast=Weng&rft.aufirst=Jun-Cheng&rft.date=2011-01-15&rft.volume=54&rft.issue=2&rft.spage=1122&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.08.046 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Electrical stimuli; Brain mapping; Neuroimaging; Amputation; Functional magnetic resonance imaging; Plasticity (neural); Cytochrome-c oxidase; Mapping; Electrophysiology; Cortex (somatosensory); Plasticity (functional) DO - http://dx.doi.org/10.1016/j.neuroimage.2010.08.046 ER - TY - JOUR T1 - A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer. AN - 822899357; 21149604 AB - Adoptive immunotherapy using TCR-engineered PBLs against melanocyte differentiation Ags mediates objective tumor regression but is associated with on-target toxicity. To avoid toxicity to normal tissues, we targeted cancer testis Ag (CTA) MAGE-A3, which is widely expressed in a range of epithelial malignancies but is not expressed in most normal tissues. To generate high-avidity TCRs against MAGE-A3, we employed a transgenic mouse model that expresses the human HLA-A*0201 molecule. Mice were immunized with two HLA-A*0201-restricted peptides of MAGE-A3: 112-120 (KVAELVHFL) or MAGE-A3: 271-279 (FLWGPRALV), and T cell clones were generated. MAGE-A3-specific TCR α- and β-chains were isolated and cloned into a retroviral vector. Expression of both TCRs in human PBLs demonstrated Ag-specific reactivity against a range of melanoma and nonmelanoma tumor cells. The TCR against MAGE-A3: 112-120 was selected for further development based on superior reactivity against tumor target cells. Interestingly, peptide epitopes from MAGE-A3 and MAGE-A12 (and to a lesser extent, peptides from MAGE-A2 and MAGE-A6) were recognized by PBLs engineered to express this TCR. To further improve TCR function, single amino acid variants of the CDR3 α-chain were generated. Substitution of alanine to threonine at position 118 of the α-chain in the CDR3 region of the TCR improved its functional avidity in CD4 and CD8 cells. On the basis of these results, a clinical trial is planned in which patients bearing a variety of tumor histologies will receive autologous PBLs that have been transduced with this optimized anti-MAGE-A3 TCR. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Chinnasamy, Nachimuthu AU - Wargo, Jennifer A AU - Yu, Zhiya AU - Rao, Mahadev AU - Frankel, Timothy L AU - Riley, John P AU - Hong, Jenny J AU - Parkhurst, Maria R AU - Feldman, Steven A AU - Schrump, David S AU - Restifo, Nicholas P AU - Robbins, Paul F AU - Rosenberg, Steven A AU - Morgan, Richard A AD - Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2011/01/15/ PY - 2011 DA - 2011 Jan 15 SP - 685 EP - 696 VL - 186 IS - 2 KW - Antigens, Neoplasm KW - 0 KW - Epitopes, T-Lymphocyte KW - HLA-A Antigens KW - HLA-A*02:01 antigen KW - HLA-A2 Antigen KW - MAGEA3 protein, human KW - Neoplasm Proteins KW - Receptors, Antigen, T-Cell, alpha-beta KW - Interferon-gamma KW - 82115-62-6 KW - Abridged Index Medicus KW - Index Medicus KW - Coculture Techniques KW - Animals KW - Breast Neoplasms -- secretion KW - Humans KW - Breast Neoplasms -- therapy KW - Immunotherapy, Adoptive -- methods KW - Melanoma -- immunology KW - Mice, Transgenic KW - Multigene Family -- immunology KW - Breast Neoplasms -- immunology KW - Melanoma -- secretion KW - Molecular Sequence Data KW - Cell Line, Transformed KW - T-Lymphocytes -- immunology KW - Carcinoma, Non-Small-Cell Lung -- therapy KW - Carcinoma, Non-Small-Cell Lung -- secretion KW - T-Lymphocytes -- transplantation KW - Cell Line, Tumor KW - Carcinoma, Non-Small-Cell Lung -- immunology KW - Amino Acid Sequence KW - Mice KW - T-Lymphocytes -- metabolism KW - Base Sequence KW - Interferon-gamma -- secretion KW - Melanoma -- therapy KW - Female KW - Cytotoxicity Tests, Immunologic -- methods KW - Neoplasm Proteins -- administration & dosage KW - Neoplasm Proteins -- biosynthesis KW - Receptors, Antigen, T-Cell, alpha-beta -- metabolism KW - Neoplasm Proteins -- immunology KW - Antigens, Neoplasm -- biosynthesis KW - Epitopes, T-Lymphocyte -- immunology KW - Antigens, Neoplasm -- administration & dosage KW - Epitopes, T-Lymphocyte -- administration & dosage KW - Epitopes, T-Lymphocyte -- metabolism KW - HLA-A Antigens -- biosynthesis KW - Receptors, Antigen, T-Cell, alpha-beta -- immunology KW - HLA-A Antigens -- metabolism KW - Antigens, Neoplasm -- immunology KW - HLA-A Antigens -- immunology KW - Receptors, Antigen, T-Cell, alpha-beta -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822899357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=A+TCR+targeting+the+HLA-A*0201-restricted+epitope+of+MAGE-A3+recognizes+multiple+epitopes+of+the+MAGE-A+antigen+superfamily+in+several+types+of+cancer.&rft.au=Chinnasamy%2C+Nachimuthu%3BWargo%2C+Jennifer+A%3BYu%2C+Zhiya%3BRao%2C+Mahadev%3BFrankel%2C+Timothy+L%3BRiley%2C+John+P%3BHong%2C+Jenny+J%3BParkhurst%2C+Maria+R%3BFeldman%2C+Steven+A%3BSchrump%2C+David+S%3BRestifo%2C+Nicholas+P%3BRobbins%2C+Paul+F%3BRosenberg%2C+Steven+A%3BMorgan%2C+Richard+A&rft.aulast=Chinnasamy&rft.aufirst=Nachimuthu&rft.date=2011-01-15&rft.volume=186&rft.issue=2&rft.spage=685&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/10.4049%2Fjimmunol.1001775 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-14 N1 - Date created - 2011-01-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4049/jimmunol.1001775 ER - TY - JOUR T1 - Psychiatric brain banking: three perspectives on current trends and future directions. AN - 821198458; 20673875 AB - Postmortem human brain tissue is critical for advancing neurobiological studies of psychiatric illness, particularly for identifying brain-specific transcripts and isoforms. State-of-the-art methods and recommendations for maintaining psychiatric brain banks are discussed in three disparate collections, the National Institute of Mental Health Brain Tissue Collection, the Harvard Brain Tissue Resource Center, and the Mount Sinai School of Medicine Alzheimer's Disease and Schizophrenia Brain Bank. While the National Institute of Mental Health Brain Tissue Collection obtains donations from medical examiners and focuses on clinical diagnosis, toxicology, and building life span control cohorts, the Harvard Brain Tissue Resource Center is designed as a repository to collect large-volume, high-quality brain tissue from community-based donors across a nationwide network, placing emphasis on the accessibility of tissue and related data to research groups worldwide. The Mount Sinai School of Medicine Alzheimer's Disease and Schizophrenia Brain Bank has shown that prospective recruitment is a successful approach to tissue donation, placing particular emphasis on clinical diagnosis through antemortem contact with donors, as well as stereological tissue sampling methods for neuroanatomical studies and frozen tissue sampling approaches that enable multiple assessments (e.g., RNA, DNA, protein, enzyme activity, binding) of the same tissue block. Promising scientific approaches for elucidating the molecular and cellular pathways in brain that may contribute to schizophrenia are briefly discussed. Despite different perspectives from three established brain collections, there is consensus that varied networking strategies, rigorous tissue and clinical characterization, sample and data accessibility, and overall adaptability are integral to the success of psychiatric brain banking. Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. JF - Biological psychiatry AU - Deep-Soboslay, Amy AU - Benes, Francine M AU - Haroutunian, Vahram AU - Ellis, Justin K AU - Kleinman, Joel E AU - Hyde, Thomas M AD - Section on Neuropathology, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2011/01/15/ PY - 2011 DA - 2011 Jan 15 SP - 104 EP - 112 VL - 69 IS - 2 KW - Index Medicus KW - United States KW - Organ Preservation KW - Autopsy KW - Postmortem Changes KW - Humans KW - Brain Chemistry KW - Specimen Handling -- standards KW - National Institutes of Health (U.S.) KW - Brain -- physiopathology KW - Tissue Banks -- trends KW - Brain -- pathology KW - Brain Diseases -- pathology KW - Neuropsychiatry -- methods KW - Brain Diseases -- physiopathology KW - Tissue Banks -- organization & administration KW - Mental Disorders -- physiopathology KW - Mental Disorders -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821198458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Psychiatric+brain+banking%3A+three+perspectives+on+current+trends+and+future+directions.&rft.au=Deep-Soboslay%2C+Amy%3BBenes%2C+Francine+M%3BHaroutunian%2C+Vahram%3BEllis%2C+Justin+K%3BKleinman%2C+Joel+E%3BHyde%2C+Thomas+M&rft.aulast=Deep-Soboslay&rft.aufirst=Amy&rft.date=2011-01-15&rft.volume=69&rft.issue=2&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=1873-2402&rft_id=info:doi/10.1016%2Fj.biopsych.2010.05.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-04-19 N1 - Date created - 2010-12-24 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Acta Psychiatr Scand. 1996 Nov;94(5):337-43 [9124080] J Neuropathol Exp Neurol. 2010 Jan;69(1):70-81 [20010301] Arch Gen Psychiatry. 1998 Mar;55(3):205-11 [9510214] Neuropsychopharmacology. 2010 Jan;35(2):473-82 [19829293] Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15873-8 [19805229] J Proteome Res. 2010 Jan;9(1):521-7 [19916557] Neuroscience. 1999;94(1):21-31 [10613493] J Chem Neuroanat. 2000 Oct;20(1):7-19 [11074340] J Neuropathol Exp Neurol. 2003 Jul;62(7):715-22 [12901698] Biol Psychiatry. 2004 Feb 15;55(4):346-52 [14960286] In Vitro. 1984 Jan;20(1):53-8 [6698573] Eur J Obstet Gynecol Reprod Biol. 1985 Mar;19(3):167-74 [3888714] Nihon Geka Gakkai Zasshi. 1993 Apr;94(4):400-11 [8321186] Ann N Y Acad Sci. 1994 Dec 15;747:225-44 [7847673] Neurosci Lett. 1995 Nov 24;200(3):151-4 [9064599] Mol Psychiatry. 1999 Jan;4(1):39-45 [10089007] Biol Psychiatry. 2005 Jan 1;57(1):96-101 [15607306] Biol Psychiatry. 2006 Jul 15;60(2):163-76 [16616896] Biol Psychiatry. 2006 Sep 15;60(6):650-8 [16997002] Prog Brain Res. 2006;158:3-14 [17027689] Brain Res. 2006 Dec 6;1123(1):1-11 [17045977] Brain Pathol. 2007 Oct;17(4):412-21 [17919127] Cell. 2007 Nov 30;131(5):861-72 [18035408] Nat Genet. 2007 Dec;39(12):1494-9 [17982457] Aust N Z J Psychiatry. 2008 Mar;42(3):221-7 [18247197] Acta Neuropathol. 2008 May;115(5):509-32 [17985145] Acta Neuropathol. 2008 May;115(5):497-507 [18365220] Clinics (Sao Paulo). 2008 Apr;63(2):255-66 [18438581] Eur Psychiatry. 2008 Jun;23(4):224-32 [18583106] Cell Tissue Bank. 2008 Sep;9(3):205-16 [18543078] Science. 2008 Aug 29;321(5893):1218-21 [18669821] Neuropsychopharmacology. 2008 Oct;33(11):2626-34 [18256595] Nat Neurosci. 2008 Nov;11(11):1271-82 [18849986] Nat Rev Neurosci. 2009 Jan;10(1):70-8 [19050713] Nature. 2009 Jan 15;457(7227):277-80 [19098894] Am J Med Sci. 2009 Jan;337(1):41-6 [19155753] Int J Mol Sci. 2009 Jan;10(1):366-84 [19333451] Nat Med. 2009 May;15(5):509-18 [19412172] Curr Opin Psychiatry. 2009 Mar;22(2):154-60 [19553869] Nat Med. 2009 Aug;15(8):834-5 [19661981] Psychopharmacology (Berl). 2009 Oct;206(2):313-24 [19652957] Br Med Bull. 2009;91:61-74 [19443537] J Psychiatr Res. 1996 Nov-Dec;30(6):421-39 [9023786] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.biopsych.2010.05.025 ER - TY - JOUR T1 - No effect of meat, meat cooking preferences, meat mutagens or heme iron on lung cancer risk in the prostate, lung, colorectal and ovarian cancer screening trial. AN - 812130221; 20232386 AB - Recent epidemiological studies have suggested that red and processed meat may increase the risk of lung cancer. Possible underlying mechanisms include mutagens produced during high-temperature cooking or preservation, or formed endogenously from heme iron in meat. We used data from 99,579 participants of both screened and nonscreened arms of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, aged 55-74 years, to investigate whether meat type, cooking method, doneness level, intake of specific meat mutagens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline] (DiMeIQx), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and benzo(a)pyrene (B(a)P)] and heme iron are associated with lung cancer. Participants' diet was assessed prospectively using a 124-item food frequency questionnaire and an additional meat-cooking module. Dietary data were used in conjunction with a database to estimate intake of MeIQx, DiMeIQx, PhIP, B(a)P and heme iron. After up to 8 years of follow-up, 782 incident lung cancer cases were ascertained. Lung cancer risk was not associated with the consumption of either red (men: HR(Q₅ vs. Q₁) = 1.11, 95% CI = 0.79-1.56, P(trend) = 0.42; women: HR(Q₅ vs. Q₁) = 1.30, 95% CI = 0.87-1.95, P(trend) = 0.65) or processed meat (men: HR(Q₅ vs. Q₁1) = 1.12, 95% CI = 0.83-1.53, P(trend) = 0.22; women: HR(Q₅ vs. Q₁) = 0.98, 95% CI = 0.68-1.41, P(trend) = 0.32) in multivariable models. High-temperature cooking methods, level of meat doneness, meat mutagens and heme iron had no effect on lung cancer risk. In this population, we found no association between meat type, cooking method, doneness level or intake of specific meat mutagens or heme iron and lung cancer risk. Copyright © 2010 UICC. JF - International journal of cancer AU - Tasevska, Nataša AU - Cross, Amanda J AU - Dodd, Kevin W AU - Ziegler, Regina G AU - Caporaso, Neil E AU - Sinha, Rashmi AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA. tasevskan@mail.nih.gov Y1 - 2011/01/15/ PY - 2011 DA - 2011 Jan 15 SP - 402 EP - 411 VL - 128 IS - 2 KW - Iron, Dietary KW - 0 KW - Mutagens KW - Index Medicus KW - Risk KW - Colorectal Neoplasms -- diagnosis KW - Prostatic Neoplasms -- diagnosis KW - Humans KW - Cooking KW - Aged KW - Middle Aged KW - Male KW - Female KW - Ovarian Neoplasms -- diagnosis KW - Lung Neoplasms -- etiology KW - Lung Neoplasms -- diagnosis KW - Meat -- adverse effects KW - Mutagens -- toxicity KW - Iron, Dietary -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/812130221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=No+effect+of+meat%2C+meat+cooking+preferences%2C+meat+mutagens+or+heme+iron+on+lung+cancer+risk+in+the+prostate%2C+lung%2C+colorectal+and+ovarian+cancer+screening+trial.&rft.au=Tasevska%2C+Nata%C5%A1a%3BCross%2C+Amanda+J%3BDodd%2C+Kevin+W%3BZiegler%2C+Regina+G%3BCaporaso%2C+Neil+E%3BSinha%2C+Rashmi&rft.aulast=Tasevska&rft.aufirst=Nata%C5%A1a&rft.date=2011-01-15&rft.volume=128&rft.issue=2&rft.spage=402&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.25327 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-04 N1 - Date created - 2010-11-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Causes Control. 1998 Dec;9(6):621-30 [10189048] Nutr Cancer. 2005;52(2):130-7 [16201844] Mol Nutr Food Res. 2005 Jul;49(7):648-55 [15986387] Am J Clin Nutr. 2009 Jun;89(6):1884-94 [19369370] Cancer Causes Control. 2000 May;11(5):419-31 [10877335] Cancer Res. 2000 Jul 15;60(14):3753-6 [10919646] Control Clin Trials. 2000 Dec;21(6 Suppl):273S-309S [11189684] Food Chem Toxicol. 2001 May;39(5):423-36 [11313108] Lung Cancer. 2001 Oct;34(1):37-46 [11557111] Am J Epidemiol. 2001 Dec 15;154(12):1089-99 [11744511] Am J Epidemiol. 2001 Dec 15;154(12):1119-25 [11744517] Jpn J Cancer Res. 2001 Dec;92(12):1259-69 [11749690] Mutat Res. 2002 Sep 30;506-507:197-204 [12351159] Cancer Epidemiol Biomarkers Prev. 2002 Oct;11(10 Pt 1):987-92 [12376497] Cancer Res. 2003 May 15;63(10):2358-60 [12750250] Mutat Res. 2003 Dec 10;533(1-2):153-71 [14643418] Cancer Epidemiol Biomarkers Prev. 2004 Feb;13(2):293-8 [14973110] Asian Pac J Cancer Prev. 2004 Jan-Mar;5(1):58-65 [15075007] Environ Mol Mutagen. 2004;44(1):44-55 [15199546] Mutat Res. 1975 Dec;31(6):347-64 [768755] J Toxicol Environ Health. 1977 Jul;2(6):1267-77 [328917] Mutat Res. 1991 Mar-Apr;259(3-4):399-410 [2017219] Epidemiology. 2005 Nov;16(6):772-9 [16222167] Am J Epidemiol. 2007 Apr 15;165(8):874-81 [17244633] Food Addit Contam. 2007 Apr;24(4):429-37 [17454117] Free Radic Biol Med. 2007 Oct 1;43(7):1040-7 [17761300] Lung Cancer. 2008 Sep;61(3):283-91 [18295929] Cancer Res. 2009 Feb 1;69(3):932-9 [19141639] Food Chem Toxicol. 2009 Apr;47(4):709-15 [19162122] Eur J Cancer. 1992;28(2-3):495-501 [1591072] Cancer Res. 1995 Oct 15;55(20):4516-9 [7553619] Lung Cancer. 1996 Jun;14(2-3):195-205 [8794403] Cancer Causes Control. 1997 Nov;8(6):883-93 [9427431] Semin Hematol. 1998 Jan;35(1):5-12 [9460805] Eur J Cancer Prev. 1997 Dec;6(6):540-9 [9496456] Food Chem Toxicol. 1998 Apr;36(4):279-87 [9651044] Food Chem Toxicol. 1998 Apr;36(4):289-97 [9651045] Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2030-4 [16103456] Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):483-90 [15734976] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.25327 ER - TY - CPAPER T1 - Tuberculosis in 2011: Major Challenges and Unprecedented Opportunities T2 - 2011 Keystone Symposia on Tuberculosis: Immunology, Cell Biology and Novel Vaccination Strategies AN - 1313006014; 6063254 JF - 2011 Keystone Symposia on Tuberculosis: Immunology, Cell Biology and Novel Vaccination Strategies AU - Fauci, Anthony Y1 - 2011/01/15/ PY - 2011 DA - 2011 Jan 15 KW - tuberculosis KW - Tuberculosis KW - Mycobacterium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313006014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Tuberculosis%3A+Immunology%2C+Cell+Biology+and+Novel+Vaccination+Strategies&rft.atitle=Tuberculosis+in+2011%3A+Major+Challenges+and+Unprecedented+Opportunities&rft.au=Fauci%2C+Anthony&rft.aulast=Fauci&rft.aufirst=Anthony&rft.date=2011-01-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Tuberculosis%3A+Immunology%2C+Cell+Biology+and+Novel+Vaccination+Strategies&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1111&CFID=387016&CFTOKEN=16964110 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - PD-1 Expression by CD4 T Cells is Required for Host Resistance to Mycobacterium tuberculosis T2 - 2011 Keystone Symposia on Tuberculosis: Immunology, Cell Biology and Novel Vaccination Strategies AN - 1312973407; 6063258 JF - 2011 Keystone Symposia on Tuberculosis: Immunology, Cell Biology and Novel Vaccination Strategies AU - Barber, Daniel Y1 - 2011/01/15/ PY - 2011 DA - 2011 Jan 15 KW - tuberculosis KW - Lymphocytes T KW - CD4 antigen KW - PD-1 protein KW - Tuberculosis KW - Mycobacterium tuberculosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312973407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Tuberculosis%3A+Immunology%2C+Cell+Biology+and+Novel+Vaccination+Strategies&rft.atitle=PD-1+Expression+by+CD4+T+Cells+is+Required+for+Host+Resistance+to+Mycobacterium+tuberculosis&rft.au=Barber%2C+Daniel&rft.aulast=Barber&rft.aufirst=Daniel&rft.date=2011-01-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Tuberculosis%3A+Immunology%2C+Cell+Biology+and+Novel+Vaccination+Strategies&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1111&CFID=387016&CFTOKEN=16964110 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - A Positive Correlation between Atypical Memory B Cells and Plasmodium falciparum Transmission Intensity in Cross-Sectional Studies in Peru and Mali AN - 876235612; 14324730 AB - Antibodies that protect against Plasmodium falciparum (Pf) malaria are only acquired after years of repeated infections. The B cell biology that underlies this observation is poorly understood. We previously reported that "atypical" memory B cells are increased in children and adults exposed to intense Pf transmission in Mali, similar to what has been observed in individuals infected with HIV. In this study we examined B cell subsets of Pf -infected adults in Peru and Mali to determine if Pf transmission intensity correlates with atypical memory B cell expansion. In this cross-sectional study venous blood was collected from adults in areas of zero (U.S., n=10), low (Peru, n=18) and high (Mali, n=12) Pf transmission. Adults in Peru and Mali were infected with Pf at the time of blood collection. Thawed lymphocytes were analyzed by flow cytometry to quantify B cell subsets, including atypical memory B cells, defined by the cell surface markers CD19+ CD20+ CD21- CD27- CD10-. In Peru, the mean level of atypical memory B cells, as a percent of total B cells, was higher than U.S. adults (Peru mean: 5.4% [95% CI: 3.61-7.28]; U.S. mean: 1.4% [95% CI: 0.92-1.81]; p&0.0001) but lower than Malian adults (Mali mean 13.1% [95% CI: 10.68-15.57]; p=0.0001). In Peru, individuals self-reporting greater than or equal to 1 prior malaria episodes had a higher percentage of atypical memory B cells compared to those reporting no prior episodes ( greater than or equal to 1 prior episodes mean: 6.6% [95% CI: 4.09-9.11]; no prior episodes mean: 3.1% [95% CI: 1.52-4.73]; p=0.028). Compared to Pf-naive controls, atypical memory B cells were increased in Peruvian adults exposed to low Pf transmission, and further increased in Malian adults exposed to intense Pf transmission. Understanding the origin, function and antigen specificity of atypical memory B cells in the context of Pf infection could contribute to our understanding of naturally-acquired malaria immunity. JF - PLoS ONE AU - Weiss, Greta E AU - Clark, Eva H AU - Li, Shanping AU - Traore, Boubacar AU - Kayentao, Kassoum AU - Ongoiba, Aissata AU - Hernandez, Jean N AU - Doumbo, Ogobara K AU - Pierce, Susan K AU - Branch, OraLee H AU - Crompton, Peter D AD - Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America Y1 - 2011/01/14/ PY - 2011 DA - 2011 Jan 14 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 6 IS - 1 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Immunology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Cell surface KW - Parasites KW - Human diseases KW - Mali KW - Immunological memory KW - Malaria KW - Lymphocytes KW - Infection KW - Public health KW - Flow cytometry KW - Antigens KW - Cytology KW - Peru KW - Lymphocytes B KW - Memory cells KW - Plasmodium falciparum KW - Children KW - Blood KW - USA KW - Antibodies KW - Human immunodeficiency virus KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876235612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=A+Positive+Correlation+between+Atypical+Memory+B+Cells+and+Plasmodium+falciparum+Transmission+Intensity+in+Cross-Sectional+Studies+in+Peru+and+Mali&rft.au=Weiss%2C+Greta+E%3BClark%2C+Eva+H%3BLi%2C+Shanping%3BTraore%2C+Boubacar%3BKayentao%2C+Kassoum%3BOngoiba%2C+Aissata%3BHernandez%2C+Jean+N%3BDoumbo%2C+Ogobara+K%3BPierce%2C+Susan+K%3BBranch%2C+OraLee+H%3BCrompton%2C+Peter+D&rft.aulast=Weiss&rft.aufirst=Greta&rft.date=2011-01-14&rft.volume=6&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0015983 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Parasites; Antibodies; Human diseases; Antigens; Cytology; Malaria; Lymphocytes; Public health; Cell surface; Blood; Lymphocytes B; Memory cells; Immunological memory; Children; Infection; Human immunodeficiency virus; Plasmodium falciparum; USA; Mali; Peru DO - http://dx.doi.org/10.1371/journal.pone.0015983 ER - TY - JOUR T1 - Regulated phosphorylation of a major UDP-glucuronosyltransferase isozyme by tyrosine kinases dictates endogenous substrate selection for detoxification. AN - 835119309; 21056984 AB - Whereas UDP-glucuronosyltransferase-2B7 is widely distributed in different tissues, it preferentially detoxifies genotoxic 4-OH-estradiol and 4-OH-estrone (4-OHE(1)) with barely detectable 17β-estradiol (E(2)) conversion following expression in COS-1 cells. Consistent with the UDP-glucuronosyltransferase requirement for regulated phosphorylation, we discovered that 2B7 requires Src-dependent tyrosine phosphorylation. Y236F-2B7 and Y438F-2B7 mutants were null and 90% inactive, respectively, when expressed in COS-1. We demonstrated that 2B7 incorporated immunoprecipitable [(33)P]orthophosphate and that 2B7His, previously expressed in SYF-(Src,Yes,Fyn)(-/-) cells, was Src-supported or phosphorylated under in vitro conditions. Unexpectedly, 2B7 expressed in SYF(-/-) and SYF(+/-) cells metabolized 4-OHE(1) at 10- and 3-fold higher rates, respectively, than that expressed in COS-1, and similar analysis showed that E(2) metabolism was 16- and 9-fold higher than in COS-1. Because anti-Tyr(P)-438-2B7 detected Tyr(P)-438-2B7 in each cell line, results indicated that unidentified tyrosine kinase(s) (TKs) phosphorylated 2B7 in SYF(-/-). 2B7-transfected COS-1 treated with increasing concentrations of the Src-specific inhibitor PP2 down-regulated 4-OHE(1) glucuronidation reaching 60% maximum while simultaneously increasing E(2) metabolism linearly. This finding indicated that increasing PP2 inhibition of Src allows increasing E(2) metabolism caused by 2B7 phosphorylation by unidentified TK(s). Importantly, 2B7 expressed in SYF(-/-) is more competent at metabolizing E(2) in cellulo than 2B7 expressed in COS-1. To confirm Src-controlled 2B7 prevents toxicity, we showed that 2B7-transfected COS-1 efficiently protected against 4-OH-E(1)-mediated depurination. Finally, our results indicate that Src-dependent phosphorylation of 2B7 allows metabolism of 4-OHE(1), but not E(2), in COS-1, whereas non-Src-phosphorylated 2B7 metabolizes both chemicals. Importantly, we determined that 2B7 substrate selection is not fixed but varies depending upon the TK(s) that carry out its required phosphorylation. JF - The Journal of biological chemistry AU - Mitra, Partha S AU - Basu, Nikhil K AU - Basu, Mousumi AU - Chakraborty, Sunit AU - Saha, Tapas AU - Owens, Ida S AD - Section on Genetic Disorders of Drug Metabolism, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1830, USA. Y1 - 2011/01/14/ PY - 2011 DA - 2011 Jan 14 SP - 1639 EP - 1648 VL - 286 IS - 2 KW - Isoenzymes KW - 0 KW - Phosphates KW - Estrone KW - 2DI9HA706A KW - Estradiol KW - 4TI98Z838E KW - UGT2B7 protein, human KW - EC 2.4.1.- KW - Glucuronosyltransferase KW - EC 2.4.1.17 KW - src-Family Kinases KW - EC 2.7.10.2 KW - Index Medicus KW - Phosphates -- metabolism KW - Animals KW - COS Cells KW - Transfection KW - Phosphorylation -- physiology KW - Humans KW - Cercopithecus aethiops KW - Substrate Specificity KW - Isoenzymes -- genetics KW - Isoenzymes -- metabolism KW - Mutagenesis KW - Cricetinae KW - Estradiol -- analogs & derivatives KW - Glucuronosyltransferase -- genetics KW - Estrone -- pharmacokinetics KW - Estrone -- analogs & derivatives KW - src-Family Kinases -- metabolism KW - Inactivation, Metabolic -- physiology KW - Glucuronosyltransferase -- metabolism KW - Estradiol -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/835119309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Regulated+phosphorylation+of+a+major+UDP-glucuronosyltransferase+isozyme+by+tyrosine+kinases+dictates+endogenous+substrate+selection+for+detoxification.&rft.au=Mitra%2C+Partha+S%3BBasu%2C+Nikhil+K%3BBasu%2C+Mousumi%3BChakraborty%2C+Sunit%3BSaha%2C+Tapas%3BOwens%2C+Ida+S&rft.aulast=Mitra&rft.aufirst=Partha&rft.date=2011-01-14&rft.volume=286&rft.issue=2&rft.spage=1639&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M110.165126 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-02 N1 - Date created - 2011-01-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 2007 Aug 17;360(1):7-13 [17586469] Proc Natl Acad Sci U S A. 2005 May 3;102(18):6285-90 [15845768] Drug Metab Dispos. 2008 Aug;36(8):1461-4 [18480185] J Biol Chem. 2008 Aug 22;283(34):23048-61 [18556656] Clin Pharmacol Ther. 2008 Dec;84(6):698-703 [18528434] Biochem Biophys Res Commun. 2009 May 15;382(4):651-6 [19289110] J Thromb Haemost. 2009 Jul;7 Suppl 1:195-9 [19630799] Mol Cell. 2009 Nov 13;36(3):525-35 [19917259] J Cell Biochem. 2000 Aug 2;79(2):274-81 [10967554] Am J Pathol. 2002 Apr;160(4):1467-79 [11943730] Clin Cancer Res. 2002 Oct;8(10):3146-55 [12374682] J Biol Chem. 2003 Mar 14;278(11):9944-52 [12645577] Oncogene. 2005 Aug 25;24(36):5629-36 [16007215] Cancer Res. 2006 Jan 1;66(1):125-33 [16397224] Int J Cancer. 2006 Apr 15;118(8):1862-8 [16287077] Biochim Biophys Acta. 2006 Aug;1766(1):63-78 [16675129] Anal Chim Acta. 2007 Apr 4;588(1):26-33 [17386790] Nat Protoc. 2006;1(1):23-9 [17406208] Xenobiotica. 2010 May;40(5):306-18 [20196639] Biochem Biophys Res Commun. 2003 Mar 28;303(1):98-104 [12646172] Biochem Pharmacol. 2003 Dec 15;66(12):2323-31 [14637190] J Biol Chem. 2004 Jan 9;279(2):1429-41 [14557274] Drug Metab Dispos. 2004 Mar;32(3):281-90 [14977861] J Biol Chem. 2004 Jul 2;279(27):28320-9 [15117964] J Clin Endocrinol Metab. 2004 Oct;89(10):5222-32 [15472229] Arch Biochem Biophys. 1984 Jun;231(2):487-97 [6428319] J Biol Chem. 1990 May 15;265(14):7900-6 [2159463] Biochemistry. 1992 Apr 7;31(13):3409-14 [1554722] J Clin Invest. 1992 Jul;90(1):150-5 [1634606] Nature. 1994 Mar 17;368(6468):237-9 [7511798] J Clin Endocrinol Metab. 1996 Apr;81(4):1460-4 [8636351] Mutat Res. 1996 Jun 12;363(2):89-96 [8676929] Carcinogenesis. 1998 Jan;19(1):1-27 [9472688] Int J Cancer. 2005 Feb 20;113(5):706-11 [15499624] J Clin Oncol. 2008 Jul 20;26(21):3560-6 [18640936] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M110.165126 ER - TY - JOUR T1 - Bortezomib resistance in mantle cell lymphoma is associated with plasmacytic differentiation. AN - 840351404; 20956803 AB - Bortezomib induces remissions in 30%-50% of patients with relapsed mantle cell lymphoma (MCL). Conversely, more than half of patients' tumors are intrinsically resistant to bortezomib. The molecular mechanism of resistance has not been defined. We generated a model of bortezomib-adapted subclones of the MCL cell lines JEKO and HBL2 that were 40- to 80-fold less sensitive to bortezomib than the parental cells. Acquisition of bortezomib resistance was gradual and reversible. Bortezomib-adapted subclones showed increased proteasome activity and tolerated lower proteasome capacity than the parental lines. Using gene expression profiling, we discovered that bortezomib resistance was associated with plasmacytic differentiation, including up-regulation of IRF4 and CD38 and expression of CD138. In contrast to plasma cells, plasmacytic MCL cells did not increase immunoglobulin secretion. Intrinsically bortezomib-resistant MCL cell lines and primary tumor cells from MCL patients with inferior clinical response to bortezomib also expressed plasmacytic features. Knockdown of IRF4 was toxic for the subset of MCL cells with plasmacytic differentiation, but only slightly sensitized cells to bortezomib. We conclude that plasmacytic differentiation in the absence of an increased secretory load can enable cells to withstand the stress of proteasome inhibition. Expression of CD38 and IRF4 could serve as markers of bortezomib resistance in MCL. This study has been registered at http://clinicaltrials.gov as NCT00131976. JF - Blood AU - Pérez-Galán, Patricia AU - Mora-Jensen, Helena AU - Weniger, Marc A AU - Shaffer, Arthur L AU - Rizzatti, Edgar G AU - Chapman, Colby M AU - Mo, Clifton C AU - Stennett, Lawrence S AU - Rader, Christoph AU - Liu, Poching AU - Raghavachari, Nalini AU - Stetler-Stevenson, Maryalice AU - Yuan, Constance AU - Pittaluga, Stefania AU - Maric, Irina AU - Dunleavy, Kieron M AU - Wilson, Wyndham H AU - Staudt, Louis M AU - Wiestner, Adrian AD - Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2011/01/13/ PY - 2011 DA - 2011 Jan 13 SP - 542 EP - 552 VL - 117 IS - 2 KW - Antineoplastic Agents KW - 0 KW - Boronic Acids KW - Interferon Regulatory Factors KW - Pyrazines KW - interferon regulatory factor-4 KW - Bortezomib KW - 69G8BD63PP KW - Antigens, CD38 KW - EC 3.2.2.5 KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Abridged Index Medicus KW - Index Medicus KW - Interferon Regulatory Factors -- biosynthesis KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Proteasome Endopeptidase Complex -- drug effects KW - Aged KW - Cell Differentiation KW - Cell Line, Tumor KW - Cell Separation KW - Antigens, CD38 -- biosynthesis KW - Gene Expression Profiling KW - Blotting, Western KW - Proteasome Endopeptidase Complex -- metabolism KW - Enzyme-Linked Immunosorbent Assay KW - Middle Aged KW - Flow Cytometry KW - Proteasome Endopeptidase Complex -- genetics KW - Male KW - Female KW - Boronic Acids -- pharmacology KW - Lymphoma, Mantle-Cell -- metabolism KW - Lymphoma, Mantle-Cell -- genetics KW - Pyrazines -- pharmacology KW - Lymphoma, Mantle-Cell -- drug therapy KW - Drug Resistance, Neoplasm -- physiology KW - Plasma Cells -- pathology KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/840351404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Bortezomib+resistance+in+mantle+cell+lymphoma+is+associated+with+plasmacytic+differentiation.&rft.au=P%C3%A9rez-Gal%C3%A1n%2C+Patricia%3BMora-Jensen%2C+Helena%3BWeniger%2C+Marc+A%3BShaffer%2C+Arthur+L%3BRizzatti%2C+Edgar+G%3BChapman%2C+Colby+M%3BMo%2C+Clifton+C%3BStennett%2C+Lawrence+S%3BRader%2C+Christoph%3BLiu%2C+Poching%3BRaghavachari%2C+Nalini%3BStetler-Stevenson%2C+Maryalice%3BYuan%2C+Constance%3BPittaluga%2C+Stefania%3BMaric%2C+Irina%3BDunleavy%2C+Kieron+M%3BWilson%2C+Wyndham+H%3BStaudt%2C+Louis+M%3BWiestner%2C+Adrian&rft.aulast=P%C3%A9rez-Gal%C3%A1n&rft.aufirst=Patricia&rft.date=2011-01-13&rft.volume=117&rft.issue=2&rft.spage=542&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=1528-0020&rft_id=info:doi/10.1182%2Fblood-2010-02-269514 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-23 N1 - Date created - 2011-01-14 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00131976; ClinicalTrials.gov N1 - SuppNotes - Cited By: Br J Haematol. 2009 Apr;145(1):34-9 [19220284] Am J Surg Pathol. 1996 May;20(5):627-40 [8619427] Cytometry B Clin Cytom. 2009 May;76(3):218-24 [19061249] Leukemia. 2009 Jun;23(6):1098-105 [19225532] Exp Hematol. 2009 Jul;37(7):831-7 [19426847] Blood. 2009 Jul 30;114(5):1046-52 [19436050] Blood. 2009 Aug 20;114(8):1489-97 [19498019] Blood. 2009 Aug 20;114(8):1469-76 [19556426] J Exp Med. 2009 Sep 28;206(10):2151-9 [19752183] Blood. 2010 Jan 21;115(3):475-80 [19965689] J Leukoc Biol. 2010 Feb;87(2):245-55 [19889725] Appl Immunohistochem Mol Morphol. 2010 Mar;18(2):103-8 [19826251] Blood. 2011 Jan 6;117(1):26-38 [20940415] Cancer Res. 1999 Jun 1;59(11):2615-22 [10363983] J Clin Oncol. 2005 Feb 1;23(4):667-75 [15613697] J Clin Oncol. 2005 Feb 1;23(4):676-84 [15613699] N Engl J Med. 2005 Jun 16;352(24):2487-98 [15958804] Leuk Res. 2006 Feb;30(2):240-1 [16081156] Blood. 2006 Jan 1;107(1):257-64 [16166592] EMBO J. 2006 Mar 8;25(5):1104-13 [16498407] Immunol Rev. 2006 Apr;210:67-85 [16623765] Nature. 2006 May 4;441(7089):106-10 [16572121] Blood. 2006 Jun 15;107(12):4907-16 [16507771] Nat Immunol. 2006 Jul;7(7):773-82 [16767092] Am J Surg Pathol. 2006 Aug;30(8):954-61 [16861965] Immunity. 2006 Aug;25(2):225-36 [16919487] J Clin Oncol. 2006 Oct 20;24(30):4867-74 [17001068] J Immunol. 2006 Dec 1;177(11):7898-904 [17114461] Leukemia. 2007 Jan;21(1):84-92 [17024115] Ann Oncol. 2007 Jan;18(1):116-21 [16971665] Cancer Res. 2007 Feb 15;67(4):1783-92 [17308121] J Clin Oncol. 2007 Apr 20;25(12):1570-5 [17353550] Nat Rev Mol Cell Biol. 2007 Jul;8(7):519-29 [17565364] Nat Rev Cancer. 2007 Oct;7(10):750-62 [17891190] J Immunol. 2008 Jan 15;180(2):800-8 [18178818] Blood. 2008 Jan 15;111(2):558-65 [17962512] Eur J Immunol. 2008 Mar;38(3):658-67 [18253932] Immunity. 2008 Mar;28(3):335-45 [18280186] Leuk Lymphoma. 2008 Apr;49(4):798-808 [18398749] Mol Cancer. 2008;7:40 [18489772] Nature. 2008 Jul 10;454(7201):226-31 [18568025] J Pharmacol Exp Ther. 2008 Aug;326(2):423-31 [18502982] Mol Cancer Res. 2008 Aug;6(8):1356-64 [18708367] Blood. 2008 Sep 15;112(6):2489-99 [18565852] Nat Rev Mol Cell Biol. 2008 Dec;9(12):944-57 [19002207] Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2200-5 [19164757] Eur J Haematol. 2002 Apr;68(4):217-24 [12071937] Immunity. 2002 Jul;17(1):51-62 [12150891] Blood. 2003 Feb 1;101(3):1128-40 [12393520] Immunity. 2003 Feb;18(2):243-53 [12594951] Cancer Cell. 2003 Feb;3(2):185-97 [12620412] Blood. 2003 May 15;101(10):4042-6 [12511405] Blood. 2003 Jun 15;101(12):4975-81 [12609845] Blood. 2003 Oct 15;102(8):3003-9 [12842981] Clin Cancer Res. 2004 May 1;10(9):3207-15 [15131062] Immunity. 2004 Jul;21(1):81-93 [15345222] Blood. 2009 Mar 26;113(13):3040-9 [19164601] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1182/blood-2010-02-269514 ER - TY - JOUR T1 - Deciphering the Clinical Presentations, Pathogenesis, and Treatment of the Idiopathic Inflammatory Myopathies AN - 904465217; 14220143 AB - The idiopathic inflammatory myopathies or myositis syndromes (the most common forms are polymyositis, dermatomyositis, and inclusion body myositis) are systemic autoimmune diseases defined by chronic muscle weakness and inflammation of unknown etiology and result in significant morbidity and mortality. Research suggests that categorizing heterogeneous myositis syndromes into mutually exclusive and stable phenotypes by using clinical and immune response features is useful for predicting clinical signs and symptoms, associated genetic and environmental risk factors, and responses to therapy and prognosis. Knowledge of myositis phenotypes should enhance clinicians' ability to recognize and manage these rare disorders. JF - JAMA: Journal of the American Medical Association AU - Rider, Lisa G AU - Miller, Frederick W AD - Author Affiliations: Environmental Autoimmunity Group, Program of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland Y1 - 2011/01/12/ PY - 2011 DA - 2011 Jan 12 SP - 183 EP - 190 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 305 IS - 2 SN - 0098-7484, 0098-7484 KW - Risk Abstracts KW - Mortality KW - Etiology KW - autoimmune diseases KW - Muscles KW - Morbidity KW - Risk factors KW - Immune response KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904465217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Deciphering+the+Clinical+Presentations%2C+Pathogenesis%2C+and+Treatment+of+the+Idiopathic+Inflammatory+Myopathies&rft.au=Rider%2C+Lisa+G%3BMiller%2C+Frederick+W&rft.aulast=Rider&rft.aufirst=Lisa&rft.date=2011-01-12&rft.volume=305&rft.issue=2&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mortality; Etiology; Risk factors; Muscles; autoimmune diseases; Immune response; Morbidity ER - TY - JOUR T1 - Methamphetamine potentiates behavioral and electrochemical responses after mild traumatic brain injury in mice AN - 860384092; 14369856 AB - We previously demonstrated that high doses of methamphetamine (MA) exacerbate damage induced by severe brain trauma. The purpose of the present study was to examine if MA, at low dosage, affected abnormalities in locomotor activity and dopamine turnover in a mouse model of mild traumatic brain injury (mTBI). Adult male CD1 mice were treated with MA (5mg/kgi.p.) or vehicle 30-min prior to mTBI, conducted by dropping a 30g metal weight onto the temporal skull, anterior the right ear. At 15min after mTBI, animals were put into locomotor activity chambers for up to 72h. During the first 3h, mTBI alone, compared with vehicle control, did not alter total distance travelled. Treatment with MA significantly increased locomotor activity in the control animals during the first 3h; mTBI reduced MA-induced hyperactivity. In contrast, at 2 and 3days after injury, mTBI or MA alone reduced locomotor activity. Co-treatment with MA and mTBI further reduced this activity, suggesting a differential and temporal behavioral interaction between MA and mTBI during acute and subacute phases after injury. Dopamine and DOPAC levels in striatal tissue were analyzed using HPLC-ECD. At 1h after mTBI or injection, DA was not altered but DOPAC level and DOPAC/DA turnover ratios were significantly reduced. Co-treatment with MA further reduced the DOPAC/DA ratio. At 36h after injury, mTBI increased tissue DA levels, but reduced DOPAC levels and DOPAC/DA ratios. Co-treatment with MA further reduced DOPAC/DA ratios in striatum. In conclusion, our data suggest that low dosage of MA worsens the suppression of locomotor responses and striatal dopamine turnover after mTBI. JF - Brain Research AU - Shen, Hui AU - Harvey, Brandon K AU - Chiang, Yung-Hsiao AU - Pick, Chaim G AU - Wang, Yun AD - National Institute on Drug Abuse, NIH, Baltimore, MD, USA, ywang@intra.nida.nih.gov Y1 - 2011/01/12/ PY - 2011 DA - 2011 Jan 12 SP - 248 EP - 253 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1368 SN - 0006-8993, 0006-8993 KW - Animal Behavior Abstracts; Toxicology Abstracts; CSA Neurosciences Abstracts KW - Metals KW - Data processing KW - Brain injury KW - Injuries KW - Animal models KW - Ear KW - Methamphetamine KW - Dopamine KW - Skull KW - Locomotor activity KW - Neostriatum KW - Traumatic brain injury KW - Immobilization KW - Hyperactivity KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25080:Orientation, Migration and Locomotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860384092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Research&rft.atitle=Methamphetamine+potentiates+behavioral+and+electrochemical+responses+after+mild+traumatic+brain+injury+in+mice&rft.au=Shen%2C+Hui%3BHarvey%2C+Brandon+K%3BChiang%2C+Yung-Hsiao%3BPick%2C+Chaim+G%3BWang%2C+Yun&rft.aulast=Shen&rft.aufirst=Hui&rft.date=2011-01-12&rft.volume=1368&rft.issue=&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Brain+Research&rft.issn=00068993&rft_id=info:doi/10.1016%2Fj.brainres.2010.10.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Metals; Brain injury; Data processing; Injuries; Animal models; Ear; Methamphetamine; Dopamine; Skull; Locomotor activity; Neostriatum; Traumatic brain injury; Immobilization; Hyperactivity DO - http://dx.doi.org/10.1016/j.brainres.2010.10.014 ER - TY - CPAPER T1 - A Prokaryote-Derived Mitochondrial Acetyltransferase Counteracts the Respiratory Effects of SIRT3 T2 - 2011 Keystone Symposia on Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction (J1) AN - 1313029031; 6064914 JF - 2011 Keystone Symposia on Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction (J1) AU - Scott, Iain Y1 - 2011/01/12/ PY - 2011 DA - 2011 Jan 12 KW - Mitochondria KW - Acetyltransferase KW - Respiration KW - Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313029031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Type+2+Diabetes%2C+Insulin+Resistance+and+Metabolic+Dysfunction+%28J1%29&rft.atitle=A+Prokaryote-Derived+Mitochondrial+Acetyltransferase+Counteracts+the+Respiratory+Effects+of+SIRT3&rft.au=Scott%2C+Iain&rft.aulast=Scott&rft.aufirst=Iain&rft.date=2011-01-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Type+2+Diabetes%2C+Insulin+Resistance+and+Metabolic+Dysfunction+%28J1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1114&CFID=365321&CFTOKEN=31334236 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Epigenetic Regulation of Adipogenesis by Histone Methylation T2 - 2011 Keystone Symposia on Obesity AN - 1313005820; 6063252 JF - 2011 Keystone Symposia on Obesity AU - Ge, Kai Y1 - 2011/01/12/ PY - 2011 DA - 2011 Jan 12 KW - Methylation KW - Histones KW - adipogenesis KW - epigenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313005820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+on+Obesity&rft.atitle=Epigenetic+Regulation+of+Adipogenesis+by+Histone+Methylation&rft.au=Ge%2C+Kai&rft.aulast=Ge&rft.aufirst=Kai&rft.date=2011-01-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+on+Obesity&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/meetings/viewPastMeetings.cfm?MeetingID=1115&CFID=367207&CFTOKEN=27625312 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Pre- and postexposure protection against virulent anthrax infection in mice by humanized monoclonal antibodies to Bacillus anthracis capsule AN - 1776644411; 14220666 AB - One of the two essential virulence factors of Bacillus anthracis is the poly- gamma -D-glutamic acid ( gamma DPGA) capsule. Five gamma DPGA-specific antibody antigen-binding fragments (Fabs) were generated from immunized chimpanzees. The two selected for further study, Fabs 11D and 4C, were both converted into full-length IgG1 and IgG3 mAbs having human IgG1 or IgG3 constant regions. These two mAbs had similar binding affinities, in vitro opsonophagocytic activities, and in vivo efficacies, with the IgG1 and IgG3 subclasses reacting similarly. The mAbs bound to gamma DPGA specifically with estimated binding affinities (Kd) of 35-70 nM and effective affinities (effective Kd) of 0.1-0.3 nM. The LD50 in an opsonophagocytic bactericidal assay was approximately 10 ng/mL of 11D or 4C. A single 30- mu g dose of either mAb given to BALB/c mice 18 h before challenge conferred about 50% protection against a lethal intratracheal spore challenge by the virulent B. anthracis Ames strain. More importantly, either mAb given 8 h or 20 h after challenge provided significant protection against lethal infection. Thus, these anti- gamma DPGA mAbs should be useful, alone or in combination with antitoxin mAbs, for achieving a safe and efficacious postexposure therapy for anthrax. JF - Proceedings of the National Academy of Sciences, USA AU - Chen, Zhaochun AU - Schneerson, Rachel AU - Lovchik, Julie AU - Lyons, CRick AU - Zhao, Huaying AU - Dai, Zhongdong AU - Kubler-Kielb, Joanna AU - Leppla, Stephen H AU - Purcell, Robert H AD - Laboratory of Infectious Diseases, Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, Program on Developmental and Molecular Immunity, National Institute of Child Health and Human Development, and National Institute for Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892 Y1 - 2011/01/11/ PY - 2011 DA - 2011 Jan 11 SP - 739 EP - 744 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 108 IS - 2 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology KW - Antitoxins KW - virulence factors KW - Monoclonal antibodies KW - Bacillus anthracis KW - Infection KW - Pan troglodytes KW - Constant region KW - Immunoglobulin G KW - Anthrax KW - Fab KW - Spores KW - Trachea KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776644411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Pre-+and+postexposure+protection+against+virulent+anthrax+infection+in+mice+by+humanized+monoclonal+antibodies+to+Bacillus+anthracis+capsule&rft.au=Chen%2C+Zhaochun%3BSchneerson%2C+Rachel%3BLovchik%2C+Julie%3BLyons%2C+CRick%3BZhao%2C+Huaying%3BDai%2C+Zhongdong%3BKubler-Kielb%2C+Joanna%3BLeppla%2C+Stephen+H%3BPurcell%2C+Robert+H&rft.aulast=Chen&rft.aufirst=Zhaochun&rft.date=2011-01-11&rft.volume=108&rft.issue=2&rft.spage=739&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Antitoxins; Constant region; virulence factors; Monoclonal antibodies; Immunoglobulin G; Anthrax; Spores; Infection; Fab; Trachea; Bacillus anthracis; Pan troglodytes ER - TY - CPAPER T1 - Centromeric Histone H3 Dynamics in Human Disease, Differentiation and Repair T2 - 2011 Keystone Symposia Conference on Histone Code: Fact or Fiction? AN - 1313025909; 6066040 JF - 2011 Keystone Symposia Conference on Histone Code: Fact or Fiction? AU - Dalal, Yamini Y1 - 2011/01/10/ PY - 2011 DA - 2011 Jan 10 KW - Differentiation KW - Histone H3 KW - Histones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313025909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Keystone+Symposia+Conference+on+Histone+Code%3A+Fact+or+Fiction%3F&rft.atitle=Centromeric+Histone+H3+Dynamics+in+Human+Disease%2C+Differentiation+and+Repair&rft.au=Dalal%2C+Yamini&rft.aulast=Dalal&rft.aufirst=Yamini&rft.date=2011-01-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Keystone+Symposia+Conference+on+Histone+Code%3A+Fact+or+Fiction%3F&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewPastMeetings.cfm?MeetingID=1064&CFID=351350&CFTOKEN=40058163 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Interferon- gamma links ultraviolet radiation to melanomagenesis in mice AN - 1093478145; 14301146 AB - Cutaneous malignant melanoma is a highly aggressive and frequently chemoresistant cancer, the incidence of which continues to rise. Epidemiological studies show that the major aetiological melanoma risk factor is ultraviolet (UV) solar radiation, with the highest risk associated with intermittent burning doses, especially during childhood. We have experimentally validated these epidemiological findings using the hepatocyte growth factor/scatter factor transgenic mouse model, which develops lesions in stages highly reminiscent of human melanoma with respect to biological, genetic and aetiological criteria, but only when irradiated as neonatal pups with UVB, not UVA. However, the mechanisms underlying UVB-initiated, neonatal-specific melanomagenesis remain largely unknown. Here we introduce a mouse model permitting fluorescence-aided melanocyte imaging and isolation following in vivo UV irradiation. We use expression profiling to show that activated neonatal skin melanocytes isolated following a melanomagenic UVB dose bear a distinct, persistent interferon response signature, including genes associated with immunoevasion. UVB-induced melanocyte activation, characterized by aberrant growth and migration, was abolished by antibody-mediated systemic blockade of interferon- gamma (IFN- gamma ), but not type-I interferons. IFN- gamma was produced by macrophages recruited to neonatal skin by UVB-induced ligands to the chemokine receptor Ccr2. Admixed recruited skin macrophages enhanced transplanted melanoma growth by inhibiting apoptosis; notably, IFN- gamma blockade abolished macrophage-enhanced melanoma growth and survival. IFN- gamma -producing macrophages were also identified in 70% of human melanomas examined. Our data reveal an unanticipated role for IFN- gamma in promoting melanocytic cell survival/immunoevasion, identifying a novel candidate therapeutic target for a subset of melanoma patients. JF - Nature AU - Zaidi, MRaza AU - Davis, Sean AU - Noonan, Frances P AU - Graff-Cherry, Cari AU - Hawley, Teresa S AU - Walker, Robert L AU - Feigenbaum, Lionel AU - Fuchs, Elaine AU - Lyakh, Lyudmila AU - Young, Howard A AU - Hornyak, Thomas J AU - Arnheiter, Heinz AU - Trinchieri, Giorgio AU - Meltzer, Paul S AU - De Fabo, Edward C AU - Merlino, Glenn AD - Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA PY - 2011 SP - 548 EP - 553 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 469 IS - 7331 SN - 0028-0836, 0028-0836 KW - Toxicology Abstracts KW - Cell survival KW - Macrophages KW - gamma -Interferon KW - Apoptosis KW - Animal models KW - Chemokine receptors KW - Melanocytes KW - Melanoma KW - Leukocyte migration KW - U.V. radiation KW - Risk factors KW - Lesions KW - growth factors KW - Skin KW - Monocyte chemoattractant protein 1 KW - melanoma KW - burning KW - Children KW - imaging KW - Cancer KW - alpha -Interferon KW - Neonates KW - survival KW - Hepatocyte growth factor KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1093478145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Interferon-+gamma+links+ultraviolet+radiation+to+melanomagenesis+in+mice&rft.au=Zaidi%2C+MRaza%3BDavis%2C+Sean%3BNoonan%2C+Frances+P%3BGraff-Cherry%2C+Cari%3BHawley%2C+Teresa+S%3BWalker%2C+Robert+L%3BFeigenbaum%2C+Lionel%3BFuchs%2C+Elaine%3BLyakh%2C+Lyudmila%3BYoung%2C+Howard+A%3BHornyak%2C+Thomas+J%3BArnheiter%2C+Heinz%3BTrinchieri%2C+Giorgio%3BMeltzer%2C+Paul+S%3BDe+Fabo%2C+Edward+C%3BMerlino%2C+Glenn&rft.aulast=Zaidi&rft.aufirst=MRaza&rft.date=2011-01-07&rft.volume=469&rft.issue=7331&rft.spage=548&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2Fnature09666 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Macrophages; Cell survival; gamma -Interferon; Monocyte chemoattractant protein 1; Apoptosis; Skin; Animal models; Chemokine receptors; Melanocytes; Children; imaging; Cancer; Melanoma; Leukocyte migration; U.V. radiation; Risk factors; alpha -Interferon; Neonates; Hepatocyte growth factor; Lesions; melanoma; burning; survival; growth factors DO - http://dx.doi.org/10.1038/nature09666 ER -