TY - JOUR T1 - Stepwise Expansion of the Bacteriophage Ie6 Procapsid: Possible Packaging Intermediates AN - 911154741; 16073113 AB - The initial assembly product of bacteriophage Ie6, the procapsid, undergoes major structural transformation during the sequential packaging of its three segments of single-stranded RNA. The procapsid, a compact icosahedrally symmetric particle with deeply recessed vertices, expands to the spherical mature capsid, increasing the volume available to accommodate the genome by 2.5-fold. It has been proposed that expansion and packaging are linked, with each stage in expansion presenting a binding site for a particular RNA segment. To investigate procapsid transformability, we induced expansion by acidification, heating, and elevated salt concentration. Cryo-electron microscopy reconstructions after all three treatments yielded the same partially expanded particle. Analysis by cryo-electron tomography showed that all vertices of a given capsid were either in a compact or an expanded state, indicating a highly cooperative transition. To benchmark the mature capsid, we analyzed filled (in vivo packaged) capsids. When these particles were induced to release their RNA, they reverted to the same intermediate state as expanded procapsids (intermediate 1) or to a second, further expanded state (intermediate 2). This partial reversibility of expansion suggests that the mature spherical capsid conformation is obtained only when sufficient outward pressure is exerted by packaged RNA. The observation of two intermediates is consistent with the proposed three-step packaging process. The model is further supported by the observation that a mutant capable of packaging the second RNA segment without previously packaging the first segment has enhanced susceptibility for switching spontaneously from the procapsid to the first intermediate state. JF - Journal of Molecular Biology AU - Nemecek, Daniel AU - Cheng, Naiqian AU - Qiao, Jian AU - Mindich, Leonard AU - Steven, Alasdair C AU - Heymann, JBernard AD - National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA, stevena@mail.nih.gov Y1 - 2011/11/25/ PY - 2011 DA - 2011 Nov 25 SP - 260 EP - 271 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 414 IS - 2 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - cryo-electron microscopy KW - Cystoviridae KW - virus KW - capsid KW - segmented genome KW - Transformation KW - Genomes KW - Phages KW - Capsids KW - Bacteria KW - Procapsids KW - Models KW - Salts KW - RNA KW - Microscopy KW - Tomography KW - Acidification KW - Pressure KW - Conformation KW - A 01490:Miscellaneous KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911154741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Stepwise+Expansion+of+the+Bacteriophage+Ie6+Procapsid%3A+Possible+Packaging+Intermediates&rft.au=Nemecek%2C+Daniel%3BCheng%2C+Naiqian%3BQiao%2C+Jian%3BMindich%2C+Leonard%3BSteven%2C+Alasdair+C%3BHeymann%2C+JBernard&rft.aulast=Nemecek&rft.aufirst=Daniel&rft.date=2011-11-25&rft.volume=414&rft.issue=2&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2011.10.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Capsids; Phages; Genomes; Transformation; Procapsids; Models; Salts; RNA; Microscopy; Tomography; Acidification; Pressure; Conformation; Bacteria DO - http://dx.doi.org/10.1016/j.jmb.2011.10.004 ER - TY - JOUR T1 - Risk of renal cell carcinoma in relation to blood telomere length in a population-based case-control study AN - 1008840200; 16450958 AB - Background: There are few known risk factors for renal cell carcinoma (RCC). Two small hospital-based case-control studies suggested an association between short blood telomere length (TL) and increased RCC risk. Methods: We conducted a large population-based case-control study in two metropolitan regions of the United States comparing relative TL in DNA derived from peripheral blood samples from 891 RCC cases and 894 controls. Odds ratios and 95% confidence intervals were estimated using unconditional logistic regression in both unadjusted and adjusted models. Results: Median TL was 0.85 for both cases and controls (P=0.40), and no differences in RCC risk by quartiles of TL were observed. Results of analyses stratified by age, sex, race, tumour stage, and time from RCC diagnosis to blood collection were similarly null. In multivariate analyses among controls, increasing age and history of hypertension were associated with shorter TL (P<0.001 and P=0.07, respectively), and African Americans had longer TL than Caucasians (P<0.001). Conclusion: These data do not support the hypothesis that blood TL is associated with RCC. This population-based case-control study is, to our knowledge, the largest investigation to date of TL and RCC. JF - British Journal of Cancer AU - Hofmann, J N AU - Baccarelli, A AU - Schwartz, K AU - Davis, F G AU - Ruterbusch, J J AU - Hoxha, M AU - McCarthy, B J AU - Savage, S A AU - Wacholder, S AU - Rothman, N AU - Graubard, B I AU - Colt, J S AU - Chow, W-H AU - Purdue, M P AD - Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, EPS 8109, Bethesda, MD 20892-7240, USA Y1 - 2011/11/22/ PY - 2011 DA - 2011 Nov 22 SP - 1772 EP - 1775 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 105 IS - 11 SN - 0007-0920, 0007-0920 KW - Biochemistry Abstracts 2: Nucleic Acids; Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Age KW - Data processing KW - Peripheral blood KW - Cancer KW - Telomeres KW - USA KW - renal cell carcinoma KW - Multivariate analysis KW - Risk factors KW - hypertension KW - Regression analysis KW - DNA KW - metropolitan areas KW - Ethnic groups KW - Metropolitan areas KW - Races KW - Hypertension KW - Sex KW - H 11000:Diseases/Injuries/Trauma KW - N 14820:DNA Metabolism & Structure KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1008840200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Risk+of+renal+cell+carcinoma+in+relation+to+blood+telomere+length+in+a+population-based+case-control+study&rft.au=Hofmann%2C+J+N%3BBaccarelli%2C+A%3BSchwartz%2C+K%3BDavis%2C+F+G%3BRuterbusch%2C+J+J%3BHoxha%2C+M%3BMcCarthy%2C+B+J%3BSavage%2C+S+A%3BWacholder%2C+S%3BRothman%2C+N%3BGraubard%2C+B+I%3BColt%2C+J+S%3BChow%2C+W-H%3BPurdue%2C+M+P&rft.aulast=Hofmann&rft.aufirst=J&rft.date=2011-11-22&rft.volume=105&rft.issue=11&rft.spage=1772&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fbjc.2011.444 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Telomeres; Age; Data processing; renal cell carcinoma; Multivariate analysis; Risk factors; DNA; Regression analysis; Peripheral blood; Races; Sex; Hypertension; Historical account; hypertension; metropolitan areas; Metropolitan areas; Ethnic groups; Cancer; USA DO - http://dx.doi.org/10.1038/bjc.2011.444 ER - TY - JOUR T1 - Fifty years of diazeniumdiolate research. From laboratory curiosity to broad-spectrum biomedical advances. AN - 905676299; 21932836 AB - Here I show that a "pure" research project, seemingly totally lacking in practical application when it was first published, can years later spark a whole new scientific field with the potential to revolutionize clinical practice. A 1961 publication describing adducts of nitric oxide (NO) with certain nucleophiles attracted little notice at the time, but later work showing that the adducts could be hydrolyzed to regenerate the NO in bioactive form has provided the foundation for a host of biomedical applications. Crucial to the discovery of widely used tools for studying NO's chemical biology as well as for the design of a variety of promising therapeutic advances has been the increasingly detailed understanding of the physicochemical properties of these "diazeniumdiolates" (also known as NONOates). JF - ACS chemical biology AU - Keefer, Larry K AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Maryland 21702, United States. Y1 - 2011/11/18/ PY - 2011 DA - 2011 Nov 18 SP - 1147 EP - 1155 VL - 6 IS - 11 KW - Azo Compounds KW - 0 KW - Protons KW - diazeniumdiolate KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Animals KW - Spectrum Analysis KW - Humans KW - Nitric Oxide -- metabolism KW - Azo Compounds -- chemical synthesis KW - Azo Compounds -- metabolism KW - Biomedical Research KW - Azo Compounds -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/905676299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+chemical+biology&rft.atitle=Fifty+years+of+diazeniumdiolate+research.+From+laboratory+curiosity+to+broad-spectrum+biomedical+advances.&rft.au=Keefer%2C+Larry+K&rft.aulast=Keefer&rft.aufirst=Larry&rft.date=2011-11-18&rft.volume=6&rft.issue=11&rft.spage=1147&rft.isbn=&rft.btitle=&rft.title=ACS+chemical+biology&rft.issn=1554-8937&rft_id=info:doi/10.1021%2Fcb200274r LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-02 N1 - Date created - 2011-11-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurosurgery. 2001 Oct;49(4):945-51; discussion 951-3 [11564257] Chem Commun (Camb). 2011 Jun 21;47(23):6710-2 [21556407] Circulation. 2002 Jun 11;105(23):2779-84 [12057994] J Org Chem. 2003 Jan 24;68(2):656-7 [12530906] Hepatology. 2003 Feb;37(2):324-33 [12540782] Mol Cancer Ther. 2003 Apr;2(4):409-17 [12700285] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5537-42 [12704230] J Am Chem Soc. 2003 May 21;125(20):6068-9 [12785832] Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9196-201 [12865500] Free Radic Biol Med. 2004 Sep 15;37(6):745-52 [15304250] J Am Chem Soc. 2004 Oct 13;126(40):12880-7 [15469285] J Natl Cancer Inst. 1972 May;48(5):1389-92 [5030954] J Med Chem. 1973 May;16(5):583-5 [4577985] Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973 May 7;79(3):141-4 [4270219] Food Cosmet Toxicol. 1976 Apr;14(2):133-5 [178581] J Natl Cancer Inst. 1980 Jun;64(6):1435-42 [6929379] IARC Sci Publ. 1982;(41):21-9 [7141531] IARC Sci Publ. 1982;(41):625-31 [7141570] Nature. 1987 Jun 11-17;327(6122):524-6 [3495737] Biochem Pharmacol. 1988 Jul 1;37(13):2495-501 [3291879] Cancer Lett. 1988 Sep-Oct;42(1-2):141-5 [3180033] Nature. 1988 Nov 24;336(6197):385-8 [2904125] Biochem Biophys Res Commun. 1988 Nov 30;157(1):87-94 [3196352] Biochemistry. 1988 Nov 29;27(24):8706-11 [3242600] J Med Chem. 1991 Nov;34(11):3242-7 [1956043] J Cardiovasc Pharmacol. 1993 Aug;22(2):287-92 [7692171] Thromb Haemost. 1993 Oct 18;70(4):654-8 [8115991] J Med Chem. 1996 Mar 1;39(5):1148-56 [8676352] Methods Enzymol. 1996;268:281-93 [8782594] J Med Chem. 1996 Oct 25;39(22):4361-5 [8893830] J Med Chem. 1997 Jun 20;40(13):1947-54 [9207935] J Neurosurg. 1997 Nov;87(5):746-51 [9347984] Bioconjug Chem. 1999 Sep-Oct;10(5):838-42 [10502351] J Am Chem Soc. 2005 Apr 20;127(15):5388-95 [15826177] J Med Chem. 2005 Jun 16;48(12):4061-7 [15943479] J Am Chem Soc. 2005 Oct 19;127(41):14188-9 [16218605] Nitric Oxide. 2005 Nov;13(3):204-9 [16122951] J Med Chem. 2005 Dec 29;48(26):8220-8 [16366603] J Med Chem. 2000 Jan 27;43(2):261-9 [10649981] Transplantation. 2001 Jan 27;71(2):193-8 [11213058] J Org Chem. 2001 May 4;66(9):3090-8 [11325274] J Am Chem Soc. 2001 Jun 13;123(23):5465-72 [11389628] J Am Chem Soc. 2001 Jun 13;123(23):5473-81 [11389629] Nitric Oxide. 2001 Aug;5(4):377-94 [11485376] Inorg Chem. 2006 Mar 20;45(6):2448-56 [16529464] J Med Chem. 2006 Jul 13;49(14):4356-66 [16821795] J Am Chem Soc. 2007 Apr 4;129(13):3786-7 [17343382] Blood. 2007 Jul 15;110(2):709-18 [17384201] Org Lett. 2007 Aug 16;9(17):3409-12 [17658755] Free Radic Biol Med. 2008 Jan 1;44(1):73-81 [18045549] J Med Chem. 2008 Jul 10;51(13):3961-70 [18533711] Angew Chem Int Ed Engl. 2009;48(47):8909-13 [19852010] Org Lett. 2010 Oct 1;12(19):4256-9 [20812718] J Am Chem Soc. 2010 Nov 24;132(46):16526-32 [21033665] J Pharmacol Exp Ther. 2011 Feb;336(2):313-20 [20962031] Inorg Chem. 2011 Apr 18;50(8):3262-70 [21405089] Biomaterials. 2002 Mar;23(6):1485-94 [11829445] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/cb200274r ER - TY - JOUR T1 - Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications. AN - 904009163; 21609791 AB - Aldehyde dehydrogenases (ALDHs) represent large family members of NAD(P)+-dependent dehydrogenases responsible for the irreversible metabolism of many endogenous and exogenous aldehydes to the corresponding acids. Among 19 ALDH isozymes, mitochondrial ALDH2 is a low Km enzyme responsible for the metabolism of acetaldehyde and lipid peroxides such as malondialdehyde and 4-hydroxynonenal, both of which are highly reactive and toxic. Consequently, inhibition of ALDH2 would lead to elevated levels of acetaldehyde and other reactive lipid peroxides following ethanol intake and/or exposure to toxic chemicals. In addition, many East Asian people with a dominant negative mutation in ALDH2 gene possess a decreased ALDH2 activity with increased risks for various types of cancer, myocardial infarct, alcoholic liver disease, and other pathological conditions. The aim of this review is to briefly describe the multiple post-translational modifications of mitochondrial ALDH2, as an example, after exposure to toxic chemicals or under different disease states and their pathophysiological roles in promoting alcohol/drug-mediated tissue damage. We also briefly mention exciting preclinical translational research opportunities to identify small molecule activators of ALDH2 and its isozymes as potentially therapeutic/preventive agents against various disease states where the expression or activity of ALDH enzymes is altered or inactivated. Published by Elsevier B.V. JF - Journal of proteomics AU - Song, Byoung-Joon AU - Abdelmegeed, Mohamed A AU - Yoo, Seong-Ho AU - Kim, Bong-Jo AU - Jo, Sangmee A AU - Jo, Inho AU - Moon, Kwan-Hoon AD - Section of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892-9410, USA. bj.song@nih.gov Y1 - 2011/11/18/ PY - 2011 DA - 2011 Nov 18 SP - 2691 EP - 2702 VL - 74 IS - 12 KW - Enzyme Activators KW - 0 KW - Lipid Peroxides KW - Mitochondrial Proteins KW - ALDH2 protein, human KW - EC 1.2.1.3 KW - Aldehyde Dehydrogenase KW - Aldehyde Dehydrogenase, Mitochondrial KW - Acetaldehyde KW - GO1N1ZPR3B KW - Index Medicus KW - Neoplasms -- drug therapy KW - Animals KW - Myocardial Infarction -- enzymology KW - Neoplasms -- enzymology KW - Myocardial Infarction -- genetics KW - Humans KW - Acetaldehyde -- metabolism KW - Asian Continental Ancestry Group -- genetics KW - Neoplasms -- genetics KW - Enzyme Activators -- therapeutic use KW - Liver Diseases, Alcoholic -- enzymology KW - Liver Diseases, Alcoholic -- genetics KW - Genes, Dominant KW - Risk Factors KW - Liver Diseases, Alcoholic -- drug therapy KW - Lipid Peroxides -- metabolism KW - Mutation KW - Myocardial Infarction -- drug therapy KW - Mitochondrial Proteins -- agonists KW - Aldehyde Dehydrogenase -- genetics KW - Protein Processing, Post-Translational KW - Mitochondrial Proteins -- genetics KW - Mitochondrial Proteins -- metabolism KW - Aldehyde Dehydrogenase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904009163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+proteomics&rft.atitle=Post-translational+modifications+of+mitochondrial+aldehyde+dehydrogenase+and+biomedical+implications.&rft.au=Song%2C+Byoung-Joon%3BAbdelmegeed%2C+Mohamed+A%3BYoo%2C+Seong-Ho%3BKim%2C+Bong-Jo%3BJo%2C+Sangmee+A%3BJo%2C+Inho%3BMoon%2C+Kwan-Hoon&rft.aulast=Song&rft.aufirst=Byoung-Joon&rft.date=2011-11-18&rft.volume=74&rft.issue=12&rft.spage=2691&rft.isbn=&rft.btitle=&rft.title=Journal+of+proteomics&rft.issn=1876-7737&rft_id=info:doi/10.1016%2Fj.jprot.2011.05.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-01 N1 - Date created - 2011-11-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Hypertens Res. 2002 Sep;25(5):677-81 [12452318] Electrophoresis. 2002 Dec;23(24):4142-56 [12481271] Mol Pharmacol. 2003 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6121061 JF - 18th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2011) AU - Hwang, PaulNB Y1 - 2011/11/16/ PY - 2011 DA - 2011 Nov 16 KW - Cancer KW - Metabolism KW - p53 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313038089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2011%29&rft.atitle=p53%2C+aerobic+metabolism+and+cancer&rft.au=Hwang%2C+PaulNB&rft.aulast=Hwang&rft.aufirst=PaulNB&rft.date=2011-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2011%29&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2011.08.114 L2 - http://submissions.miracd.com/sfrbm2011/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Leptin is key to macrophage-dependent free radical formation in CCl4-induced exacerbation of steatohepatitis of obesity T2 - 18th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2011) AN - 1313026155; 6121316 JF - 18th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2011) AU - Chatterjee, Saurabh AU - Tokar, Erik AU - Kadiiska, Maria AU - Waalkes, Michael AU - Mae Diehl, Anna AU - Mason, Ronald Y1 - 2011/11/16/ PY - 2011 DA - 2011 Nov 16 KW - Obesity KW - Leptin KW - Free radicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313026155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2011%29&rft.atitle=Leptin+is+key+to+macrophage-dependent+free+radical+formation+in+CCl4-induced+exacerbation+of+steatohepatitis+of+obesity&rft.au=Chatterjee%2C+Saurabh%3BTokar%2C+Erik%3BKadiiska%2C+Maria%3BWaalkes%2C+Michael%3BMae+Diehl%2C+Anna%3BMason%2C+Ronald&rft.aulast=Chatterjee&rft.aufirst=Saurabh&rft.date=2011-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2011/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Effect of intermittent pneumatic compression of legs on blood nitric oxide and brachial artery diameter T2 - 18th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2011) AN - 1313009602; 6121290 JF - 18th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2011) AU - Nagababu, EnikaNB AU - Salgado, MariaNB AU - Lima, SandraNB AU - Lima, MichaelNB AU - Silber, HarryNB AU - Rifkind, JosephNB Y1 - 2011/11/16/ PY - 2011 DA - 2011 Nov 16 KW - Nitric oxide KW - Blood KW - Leg KW - Arteries KW - Compression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313009602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2011%29&rft.atitle=Effect+of+intermittent+pneumatic+compression+of+legs+on+blood+nitric+oxide+and+brachial+artery+diameter&rft.au=Nagababu%2C+EnikaNB%3BSalgado%2C+MariaNB%3BLima%2C+SandraNB%3BLima%2C+MichaelNB%3BSilber%2C+HarryNB%3BRifkind%2C+JosephNB&rft.aulast=Nagababu&rft.aufirst=EnikaNB&rft.date=2011-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2011/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - New and improved immuno-spin trapping methods for the detection of DNA radicals T2 - 18th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2011) AN - 1312964590; 6121329 JF - 18th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2011) AU - Summers, FionaNB AU - Mason, RonaldNB AU - Ehrenshaft, MarilynNB Y1 - 2011/11/16/ PY - 2011 DA - 2011 Nov 16 KW - Radicals KW - Trapping UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312964590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2011%29&rft.atitle=New+and+improved+immuno-spin+trapping+methods+for+the+detection+of+DNA+radicals&rft.au=Summers%2C+FionaNB%3BMason%2C+RonaldNB%3BEhrenshaft%2C+MarilynNB&rft.aulast=Summers&rft.aufirst=FionaNB&rft.date=2011-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2011/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - The effects of resveratrol and selected metabolites on the radiation and antioxidant response. AN - 912797249; 22024758 AB - Excess reactive oxygen species (ROS) generated from ionizing radiation (IR) or endogenous sources like cellular respiration and inflammation produce cytotoxic effects that can lead to carcinogenesis. Resveratrol (RSV), a polyphenol with antioxidant and anticarcinogenic capabilities, has shown promise as a potential radiation modifier. The present study focuses on examining the effects of RSV or RSV metabolites as a radiation modifier in normal tissue. RSV or a RSV metabolite, piceatannol (PIC) did not protect human lung fibroblasts (1522) from the radiation-induced cell killing. Likewise, neither RSV nor PIC afforded protection against lethal total body IR in C3H mice. Additional research has shown protection in cells against hydrogen peroxide when treated with RSV. Therefore, clonogenic survival was measured in 1522 cells with RSV and RSV metabolites. Only the RSV derivative, piceatannol (PIC), showed protection against hydrogen peroxide mediated cytotoxicity; whereas, RSV enhanced hydrogen peroxide sensitivity at a 50 µM concentration; the remaining metabolites evaluated had little to no effect on survival. PIC also showed enhancement to peroxide exposure at a higher concentration (150 µM). A potential mechanism for RSV-induced sensitivity to peroxides could be its ability to block 1522 cells in the S-phase, which is most sensitive to hydrogen peroxide treatment. In addition, both RSV and PIC can be oxidized to phenoxyl radicals and quinones, which may exert cytotoxic effects. These cytotoxic effects were abolished when HBED, a metal chelator, was added. Taken together RSV and many of its metabolic derivatives are not effective as chemical radioprotectors and should not be considered for clinical use. JF - Cancer biology & therapy AU - Fabre, Kristin M AU - Saito, Keita AU - DeGraff, William AU - Sowers, Anastasia L AU - Thetford, Angela AU - Cook, John A AU - Krishna, Murali C AU - Mitchell, James B AD - Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA. fabrek@mail.nih.gov Y1 - 2011/11/15/ PY - 2011 DA - 2011 Nov 15 SP - 915 EP - 923 VL - 12 IS - 10 KW - Antioxidants KW - 0 KW - Phenols KW - Quinones KW - Radiation-Protective Agents KW - Stilbenes KW - phenoxy radical KW - 3229-70-7 KW - N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid KW - 35998-29-9 KW - 3,3',4,5'-tetrahydroxystilbene KW - 6KS3LS0D4F KW - tert-Butylhydroperoxide KW - 955VYL842B KW - Edetic Acid KW - 9G34HU7RV0 KW - Hydrogen Peroxide KW - BBX060AN9V KW - resveratrol KW - Q369O8926L KW - Index Medicus KW - Animals KW - Fibroblasts -- drug effects KW - Dose-Response Relationship, Drug KW - Humans KW - Phenols -- metabolism KW - Mice KW - Fibroblasts -- metabolism KW - Quinones -- metabolism KW - Hydrogen Peroxide -- toxicity KW - Edetic Acid -- analogs & derivatives KW - Whole-Body Irradiation KW - Cell Survival -- drug effects KW - Oxidative Stress -- drug effects KW - Mice, Inbred C3H KW - Fibroblasts -- radiation effects KW - Cell Survival -- radiation effects KW - tert-Butylhydroperoxide -- toxicity KW - Cell Cycle -- drug effects KW - Edetic Acid -- pharmacology KW - Female KW - Antioxidants -- metabolism KW - Antioxidants -- pharmacology KW - Stilbenes -- pharmacology KW - Radiation-Protective Agents -- metabolism KW - Radiation-Protective Agents -- pharmacology KW - Stilbenes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912797249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=The+effects+of+resveratrol+and+selected+metabolites+on+the+radiation+and+antioxidant+response.&rft.au=Fabre%2C+Kristin+M%3BSaito%2C+Keita%3BDeGraff%2C+William%3BSowers%2C+Anastasia+L%3BThetford%2C+Angela%3BCook%2C+John+A%3BKrishna%2C+Murali+C%3BMitchell%2C+James+B&rft.aulast=Fabre&rft.aufirst=Kristin&rft.date=2011-11-15&rft.volume=12&rft.issue=10&rft.spage=915&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=1555-8576&rft_id=info:doi/10.4161%2Fcbt.12.10.17714 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-17 N1 - Date created - 2011-12-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Free Radic Biol Med. 2001 Jan 15;30(2):170-7 [11163534] Chem Biol Interact. 2011 Aug 15;193(1):34-42 [21570383] Cancer Lett. 2002 Jan 25;175(2):165-73 [11741744] Mil Med. 2002 Feb;167(2 Suppl):49-50 [11873514] Pharm Res. 2002 Dec;19(12):1907-14 [12523673] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5390-5 [12702779] Biochem Biophys Res Commun. 2003 Oct 3;309(4):1017-26 [13679076] Int J Mol Med. 2004 Jun;13(6):895-902 [15138632] Radiat Res. 1970 Jun;42(3):451-70 [5463516] Radiat Res. 1984 Mar;97(3):598-607 [6328565] Radiat Res. 1987 Sep;111(3):385-405 [3659275] Prog Nucleic Acid Res Mol Biol. 1988;35:95-125 [3065826] Radiat Res. 1989 Jun;118(3):437-66 [2727270] Int J Radiat Biol. 1994 Jan;65(1):27-33 [7905906] Prog Clin Biol Res. 1995;391:103-16 [8532709] Ann N Y Acad Sci. 1998 Nov 20;854:425-34 [9928449] Science. 1963 May 3;140(3566):490-2 [13980636] Int J Mol Med. 2005 Feb;15(2):337-52 [15647852] Biochem Pharmacol. 2005 Mar 15;69(6):903-12 [15748702] Int J Mol Med. 2005 Jun;15(6):1005-12 [15870907] Mutat Res. 2005 Jul 1;574(1-2):124-38 [15914212] J Radiat Res. 2005 Dec;46(4):387-93 [16394628] Nat Rev Drug Discov. 2006 Jun;5(6):493-506 [16732220] Oncol Rep. 2006 Sep;16(3):617-24 [16865264] J Mol Histol. 2006 Sep;37(5-7):203-18 [16868862] Cancer Lett. 2007 Aug 8;253(1):124-30 [17321671] Drug Discov Today. 2007 Oct;12(19-20):794-805 [17933679] Chem Res Toxicol. 2008 Jan;21(1):93-101 [18052105] Apoptosis. 2008 Jun;13(6):790-802 [18454317] Radiat Res. 2008 Jun;169(6):633-8 [18494544] Radiat Res. 2008 Dec;170(6):784-93 [19138034] Int J Radiat Oncol Biol Phys. 2009 May 1;74(1):219-28 [19362240] Drug Metab Rev. 2009;41(2):89-295 [19514967] Environ Mol Mutagen. 2009 Dec;50(9):771-80 [19449395] Anticancer Drugs. 2010 Feb;21(2):140-50 [20010425] Toxicol In Vitro. 2010 Apr;24(3):916-20 [19945524] Oncologist. 2010;15(4):360-71 [20413641] Crit Rev Food Sci Nutr. 2009 Oct;49(9):782-99 [20443159] Science. 1949 Aug 26;110(2852):213-4 [17811258] Free Radic Res. 2009;43(11):1060-71 [19707923] J Radiat Res. 2010;51(4):473-9 [20679743] PLoS One. 2010;5(8):e12124 [20711342] Semin Oncol. 2010 Jun;37(3):258-81 [20709209] Oxid Med Cell Longev. 2010 Mar-Apr;3(2):86-100 [20716933] Nutr Cancer. 2010;62(7):938-46 [20924969] Ann N Y Acad Sci. 2011 Jan;1215:48-59 [21261641] Int J Mol Med. 2011 Mar;27(3):441-6 [21249311] Mutat Res. 2011 Jun 3;711(1-2):193-201 [21216256] EMBO J. 2001 Jun 1;20(11):2896-906 [11387222] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4161/cbt.12.10.17714 ER - TY - JOUR T1 - Effects of ascorbic acid on carcinogenicity and acute toxicity of nickel subsulfide, and on tumor transplants growth in gulonolactone oxidase knock-out mice and wild-type C57BL mice AN - 911168502; 16076117 AB - The aim of this study was to test a hypothesis that ascorbate depletion could enhance carcinogenicity and acute toxicity of nickel. Homozygous l-gulono-gamma>-lactone oxidase gene knock-out mice (Gulo-/- mice) unable to produce ascorbate and wild-type C57BL mice (WT mice) were injected intramuscularly with carcinogenic nickel subsulfide (Ni3S2), and observed for the development of injection site tumors for 57weeks. Small pieces of one of the induced tumors were transplanted subcutaneously into separate groups of Gulo-/- and WT mice and the growth of these tumors was measured for up to 3months. The two strains of mice differed significantly with regard to (1) Ni3S2 carcinogenesis: Gulo-/- mice were 40% more susceptible than WT mice; and (2) transplanted tumors development: Gulo-/- mice were more receptive to tumor growth than WT mice, but only in terms of a much shorter tumor latency; later in the exponential phase of growth, the growth rates were the same. And, with adequate ascorbate supplementation, the two strains were equally susceptible to acute toxicity of Ni3S2. Statistically significant effects of dietary ascorbate dosing levels were the following: (1) reduction in ascorbate supplementation increased acute toxicity of Ni3S2 in Gulo-/- mice; (2) ascorbate supplementation extended the latency of transplanted tumors in WT mice. In conclusion, the lack of endogenous ascorbate synthesis makes Gulo-/- mice more susceptible to Ni3S2 carcinogenesis. Dietary ascorbate tends to attenuate acute toxicity of Ni3S2 and to extend the latency of transplanted tumors. The latter effects may be of practical importance to humans and thus deserve further studies. JF - Toxicology and Applied Pharmacology AU - Kasprzak, Kazimierz S AU - Diwan, Bhalchandra A AU - Kaczmarek, Monika Z AU - Logsdon, Daniel L AU - Fivash, Mathew J AU - Salnikow, Konstantin AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA, salnikok@mail.nih.gov Y1 - 2011/11/15/ PY - 2011 DA - 2011 Nov 15 SP - 32 EP - 37 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 257 IS - 1 SN - 0041-008X, 0041-008X KW - Toxicology Abstracts KW - Growth rate KW - Dietary supplements KW - Nickel KW - Carcinogenesis KW - Statistical analysis KW - Tumors KW - Acute toxicity KW - Ascorbic acid KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911168502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Effects+of+ascorbic+acid+on+carcinogenicity+and+acute+toxicity+of+nickel+subsulfide%2C+and+on+tumor+transplants+growth+in+gulonolactone+oxidase+knock-out+mice+and+wild-type+C57BL+mice&rft.au=Kasprzak%2C+Kazimierz+S%3BDiwan%2C+Bhalchandra+A%3BKaczmarek%2C+Monika+Z%3BLogsdon%2C+Daniel+L%3BFivash%2C+Mathew+J%3BSalnikow%2C+Konstantin&rft.aulast=Kasprzak&rft.aufirst=Kazimierz&rft.date=2011-11-15&rft.volume=257&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2011.08.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Growth rate; Dietary supplements; Carcinogenesis; Nickel; Statistical analysis; Acute toxicity; Tumors; Ascorbic acid DO - http://dx.doi.org/10.1016/j.taap.2011.08.015 ER - TY - JOUR T1 - Myeloablative doses of yttrium-90-ibritumomab tiuxetan and the risk of secondary myelodysplasia/acute myelogenous leukemia. AN - 902332333; 21567384 AB - Because the long-term toxicity of myeloablative radioimmunotherapy remains a matter of concern, the authors evaluated the hematopoietic damage and incidence of secondary myelodysplastic syndrome and acute myelogenous leukemia (sMDS/AML) in patients who received myeloablative doses of the radiolabeled antibody yttrium-90 (⁹⁰Y)-ibritumomab tiuxetan. The occurrence of sMDS/AML was investigated prospectively in 53 elderly patients with non-Hodgkin lymphoma (NHL) who underwent an autograft after high-dose radioimmunotherapy (HD-RIT) myeloablative conditioning with ⁹⁰Y-ibritumomab tiuxetan. Bone marrow (BM) hematopoietic progenitors and telomere length (TL) also were investigated. At a median follow-up of 49 months, 4 patients developed sMDS/AML at 6 months, 12 months, 27 months, and 36 months after HD-RIT, and the 5-year cumulative incidence of sMDS/AML was 8.29%. A significant but transient decrease in BM granulocyte-macrophage progenitors was observed; whereas multilineage, erythroid, and fibroblast progenitors were unaffected. A significant and persistent shortening of BM TL also was detected. A matched-pair analysis comparing the study patients with 55 NHL patients who underwent autografts after chemotherapy-based myeloablative conditioning demonstrated a 8.05% 5-year cumulative incidence of sMDS/AML. HD-RIT for patients with NHL was associated with 1) limited toxicity on hematopoietic progenitors, 2) accelerated TL shortening, and 3) non-negligible incidence of sMDS/AML, which nevertheless was comparable to the incidence observed in a matched group of patients who received chemotherapy-based conditioning. Thus, in the current series of elderly patients with NHL, the development of sMDS/AML was not influenced substantially by HD-RIT. Copyright © 2011 American Cancer Society. JF - Cancer AU - Guidetti, Anna AU - Carlo-Stella, Carmelo AU - Ruella, Marco AU - Miceli, Rosalba AU - Devizzi, Lilli AU - Locatelli, Silvia L AU - Giacomini, Arianna AU - Testi, Adele AU - Buttiglieri, Stefano AU - Risso, Alessandra AU - Mariani, Luigi AU - Di Nicola, Massimo AU - Passera, Roberto AU - Tarella, Corrado AU - Gianni, Alessandro M AD - Medical Oncology 3, National Cancer Institute, Milan, Italy. Y1 - 2011/11/15/ PY - 2011 DA - 2011 Nov 15 SP - 5074 EP - 5084 VL - 117 IS - 22 KW - Antibodies, Monoclonal KW - 0 KW - Yttrium Radioisotopes KW - ibritumomab tiuxetan KW - 4Q52C550XK KW - Abridged Index Medicus KW - Index Medicus KW - Bone Marrow -- pathology KW - Humans KW - Hematopoietic Stem Cells -- cytology KW - Aged KW - Hematopoietic Stem Cells -- drug effects KW - Risk KW - Lymphoma, Non-Hodgkin -- drug therapy KW - Telomere -- drug effects KW - Lymphoma, Non-Hodgkin -- radiotherapy KW - Adult KW - Granulocyte-Macrophage Progenitor Cells -- cytology KW - Telomere -- radiation effects KW - Middle Aged KW - Follow-Up Studies KW - Bone Marrow -- radiation effects KW - Bone Marrow -- drug effects KW - Hematopoietic Stem Cells -- radiation effects KW - Male KW - Female KW - Yttrium Radioisotopes -- therapeutic use KW - Neoplasms, Second Primary -- etiology KW - Radioimmunotherapy -- adverse effects KW - Leukemia, Myeloid, Acute -- etiology KW - Yttrium Radioisotopes -- adverse effects KW - Antibodies, Monoclonal -- adverse effects KW - Myelodysplastic Syndromes -- etiology KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902332333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Myeloablative+doses+of+yttrium-90-ibritumomab+tiuxetan+and+the+risk+of+secondary+myelodysplasia%2Facute+myelogenous+leukemia.&rft.au=Guidetti%2C+Anna%3BCarlo-Stella%2C+Carmelo%3BRuella%2C+Marco%3BMiceli%2C+Rosalba%3BDevizzi%2C+Lilli%3BLocatelli%2C+Silvia+L%3BGiacomini%2C+Arianna%3BTesti%2C+Adele%3BButtiglieri%2C+Stefano%3BRisso%2C+Alessandra%3BMariani%2C+Luigi%3BDi+Nicola%2C+Massimo%3BPassera%2C+Roberto%3BTarella%2C+Corrado%3BGianni%2C+Alessandro+M&rft.aulast=Guidetti&rft.aufirst=Anna&rft.date=2011-11-15&rft.volume=117&rft.issue=22&rft.spage=5074&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=1097-0142&rft_id=info:doi/10.1002%2Fcncr.26182 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-09 N1 - Date created - 2011-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/cncr.26182 ER - TY - CPAPER T1 - Nicotine preexposure in periadolescence or early adulthood alters the aversive, physiological and reinforcing effects of alcohol. T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313102885; 6106610 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Rinker, J AU - DeCicco-Skinner, K AU - Thorsell, A AU - Heilig, M AU - Riley, A Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Nicotine KW - alcohols KW - Physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313102885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Decreased+microRNA-214+levels+in+breast+cancer+cells+coincides+with+increased+cell+proliferation%2C+invasion+and+accumulation+of+the+Polycomb+Ezh2+methyltransferase&rft.au=Derfoul%2C+Assia%3BJuan%2C+Aster+H%3BDifilippantonio%2C+Michael+J%3BPalanisamy%2C+Nallasivam%3BRied%2C+Thomas%3BSartorelli%2C+Vittorio&rft.aulast=Derfoul&rft.aufirst=Assia&rft.date=2011-11-01&rft.volume=32&rft.issue=11&rft.spage=1607&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgr184 L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Early postnatal NMDA receptor ablation alters interneuronal activity in a mouse model of schizophrenia T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313099063; 6105569 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Zsiros, V AU - Nakazawa, K Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Mental disorders KW - Schizophrenia KW - Animal models KW - N-Methyl-D-aspartic acid receptors KW - Glutamic acid receptors (ionotropic) KW - Ablation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313099063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Early+postnatal+NMDA+receptor+ablation+alters+interneuronal+activity+in+a+mouse+model+of+schizophrenia&rft.au=Zsiros%2C+V%3BNakazawa%2C+K&rft.aulast=Zsiros&rft.aufirst=V&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Hippocampal volume shows rapid increases in response to exercise in sedentary adults T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313062978; 6106466 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Thomas, A AU - Dennis, A AU - Rawlings, N AU - Matthews, L AU - Stagg, C AU - Morris, M AU - Bandettini, P AU - Dawes, H AU - Johansen-Berg, H Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Hippocampus KW - Physical training UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313062978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Hippocampal+volume+shows+rapid+increases+in+response+to+exercise+in+sedentary+adults&rft.au=Thomas%2C+A%3BDennis%2C+A%3BRawlings%2C+N%3BMatthews%2C+L%3BStagg%2C+C%3BMorris%2C+M%3BBandettini%2C+P%3BDawes%2C+H%3BJohansen-Berg%2C+H&rft.aulast=Thomas&rft.aufirst=A&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Decreased mature synapses and increased excitability of cortical neurons in transgenic mice expressing the schizophrenia associated KCNH2 3.1 isoform T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313062926; 6105066 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Chen, J AU - Yuan, P AU - Tian, Q AU - Yang, F AU - Zhang, G AU - Jia, J AU - Wang, Y AU - Du, J. AU - Glineburg, P AU - Carr, G AU - Papaleo, F AU - Pickel, J AU - Li, Z. AU - Daniel, W Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Mental disorders KW - Mice KW - Schizophrenia KW - Cortex KW - Excitability KW - Synapses KW - Transgenic mice KW - Neurons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313062926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Decreased+mature+synapses+and+increased+excitability+of+cortical+neurons+in+transgenic+mice+expressing+the+schizophrenia+associated+KCNH2+3.1+isoform&rft.au=Chen%2C+J%3BYuan%2C+P%3BTian%2C+Q%3BYang%2C+F%3BZhang%2C+G%3BJia%2C+J%3BWang%2C+Y%3BDu%2C+J.%3BGlineburg%2C+P%3BCarr%2C+G%3BPapaleo%2C+F%3BPickel%2C+J%3BLi%2C+Z.%3BDaniel%2C+W&rft.aulast=Chen&rft.aufirst=J&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Vision in action: An ascending pulvinar path from brainstem to cortex T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313060356; 6104704 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Berman, R Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Vision KW - Cortex KW - Pulvinar KW - Brain stem UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313060356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Vision+in+action%3A+An+ascending+pulvinar+path+from+brainstem+to+cortex&rft.au=Berman%2C+R&rft.aulast=Berman&rft.aufirst=R&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Functional imaging of the interaction between anxiety and cognitive load T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313058284; 6104415 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Vytal, K AU - Robinson, O AU - Charney, D AU - Overstreet, C AU - Grillon, C Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Anxiety KW - Imaging techniques KW - Cognitive ability UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313058284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Functional+imaging+of+the+interaction+between+anxiety+and+cognitive+load&rft.au=Vytal%2C+K%3BRobinson%2C+O%3BCharney%2C+D%3BOverstreet%2C+C%3BGrillon%2C+C&rft.aulast=Liu&rft.aufirst=Xunxian&rft.date=2011-11-01&rft.volume=32&rft.issue=11&rft.spage=1648&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgr206 L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Oxytocin induces synaptic potentiation in hippocampal CA2 neurons T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313057755; 6105136 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Zhao, M AU - Young, 3rd, W. AU - Dudek, S Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Oxytocin KW - Potentiation KW - Hippocampus KW - Neurons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313057755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Oxytocin+induces+synaptic+potentiation+in+hippocampal+CA2+neurons&rft.au=Zhao%2C+M%3BYoung%2C+3rd%2C+W.%3BDudek%2C+S&rft.aulast=Zhao&rft.aufirst=M&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Hippocampal area CA2 is particularly sensitive to adenosine-induced synaptic depression T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313057706; 6105134 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Caruana, D AU - Simons, S AU - Dudek, S Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Depression KW - Hippocampus KW - synaptic depression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313057706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Hippocampal+area+CA2+is+particularly+sensitive+to+adenosine-induced+synaptic+depression&rft.au=Caruana%2C+D%3BSimons%2C+S%3BDudek%2C+S&rft.aulast=Caruana&rft.aufirst=D&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Common variation in the DARPP-32 gene is associated with presynaptic dopamine in healthy humans T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313054193; 6105020 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Eisenberg, D AU - Masdeu, J AU - Ianni, A AU - Baller, E AU - Kolachana, B AU - Weinberger, D AU - Berman, K Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - DARPP-32 protein KW - Dopamine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313054193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Common+variation+in+the+DARPP-32+gene+is+associated+with+presynaptic+dopamine+in+healthy+humans&rft.au=Eisenberg%2C+D%3BMasdeu%2C+J%3BIanni%2C+A%3BBaller%2C+E%3BKolachana%2C+B%3BWeinberger%2C+D%3BBerman%2C+K&rft.aulast=Eisenberg&rft.aufirst=D&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - N-arachidonyl glycine (NAGly) does not activate heterologously expressed G-protein receptor 18 (GPR18) in a native neuronal system T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313053996; 6103348 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Lu, V. AU - Puhl III, H AU - Ikeda, S Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Glycine KW - Guanine nucleotide-binding protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313053996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=N-arachidonyl+glycine+%28NAGly%29+does+not+activate+heterologously+expressed+G-protein+receptor+18+%28GPR18%29+in+a+native+neuronal+system&rft.au=Lu%2C+V.%3BPuhl+III%2C+H%3BIkeda%2C+S&rft.aulast=Lu&rft.aufirst=V.&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Chloride transporter expression and function in developing GnRH-1 neurons T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313052880; 6104273 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Taylorburds, C AU - Wray, S Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Chloride KW - Neurons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313052880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Chloride+transporter+expression+and+function+in+developing+GnRH-1+neurons&rft.au=Taylorburds%2C+C%3BWray%2C+S&rft.aulast=Taylorburds&rft.aufirst=C&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Integration of neuroendocrine signals on GnRH-1 neurons T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313052843; 6104271 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Klenke, U AU - Wray, S Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Integration KW - Neurons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313052843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Integration+of+neuroendocrine+signals+on+GnRH-1+neurons&rft.au=Klenke%2C+U%3BWray%2C+S&rft.aulast=Klenke&rft.aufirst=U&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Dopamine D5 receptor knockout mice display prefrontal cortex-dependent cognitive deficits T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313052090; 6104490 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Carr, G AU - Sibley, D AU - Weinberger, D AU - Papaleo, F Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Mice KW - Cognitive ability KW - Dopamine D5 receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313052090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Dopamine+D5+receptor+knockout+mice+display+prefrontal+cortex-dependent+cognitive+deficits&rft.au=Carr%2C+G%3BSibley%2C+D%3BWeinberger%2C+D%3BPapaleo%2C+F&rft.aulast=Carr&rft.aufirst=G&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Corticostriatal mediation of choice learning and flexibility in the mouse T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313051809; 6104482 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Brigman, J AU - Graybeal, C AU - Wright, T AU - Capik, N AU - Davis, M AU - Jiang, Z AU - Pease, M AU - Saksida, L AU - Bussey, T AU - Nakazawa, K AU - Lovinger, D AU - Holmes, A Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Choice learning KW - Cortex UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313051809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Corticostriatal+mediation+of+choice+learning+and+flexibility+in+the+mouse&rft.au=Brigman%2C+J%3BGraybeal%2C+C%3BWright%2C+T%3BCapik%2C+N%3BDavis%2C+M%3BJiang%2C+Z%3BPease%2C+M%3BSaksida%2C+L%3BBussey%2C+T%3BNakazawa%2C+K%3BLovinger%2C+D%3BHolmes%2C+A&rft.aulast=Brigman&rft.aufirst=J&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Time-lapse observation of synapse formation in vivo revealed that rapsyn transport and clustering requires acetylcholine receptors T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313051633; 6103464 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Park, J AU - Ikenaga, T AU - Ono, F Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - rapsyn KW - Protein transport KW - Acetylcholine receptors KW - Synaptogenesis KW - Neurotransmitters KW - Synapses UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313051633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Time-lapse+observation+of+synapse+formation+in+vivo+revealed+that+rapsyn+transport+and+clustering+requires+acetylcholine+receptors&rft.au=Park%2C+J%3BIkenaga%2C+T%3BOno%2C+F&rft.aulast=Park&rft.aufirst=J&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Cortico-nigral network synchronization across behavioral states: Motor activity, rest, sleep and anesthesia in a rodent model of Parkinson's disease T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313051217; 6104134 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Wahba, M AU - Brazhnik, E AU - Mccoy, A AU - Novikov, N AU - Ilieva, N AU - Walters, J Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Parkinson's disease KW - anesthesia KW - Rodents KW - Movement disorders KW - Neurodegenerative diseases KW - Animal models KW - Sleep KW - Anesthesia KW - Synchronization KW - Motor activity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313051217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Risk&rft.atitle=Clinical+risk+in+paediatrics%3A+Medicines&rft.au=Anderson%2C+Mark&rft.aulast=Anderson&rft.aufirst=Mark&rft.date=2011-11-01&rft.volume=17&rft.issue=6&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Clinical+Risk&rft.issn=13562622&rft_id=info:doi/10.1258%2Fcr.2011.011044 L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Polyamidoamine (PAMAM) dendrimer conjugates of neuroprotective adenosine receptor antagonists T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313049450; 6105821 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Jacobson, K AU - Kumar, T AU - Deflorian, F AU - Kecskes, A AU - Phan, K AU - Gao, Z AU - Tosh, D Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Adenosine receptors KW - Neuroprotection KW - Antagonists KW - polyamidoamines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313049450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Polyamidoamine+%28PAMAM%29+dendrimer+conjugates+of+neuroprotective+adenosine+receptor+antagonists&rft.au=Jacobson%2C+K%3BKumar%2C+T%3BDeflorian%2C+F%3BKecskes%2C+A%3BPhan%2C+K%3BGao%2C+Z%3BTosh%2C+D&rft.aulast=Jacobson&rft.aufirst=K&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Electron tomography of the GABAergic post-synaptic density in dissociated hippocampal neurons T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313046379; 6103460 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Linsalata, A AU - Chen, X AU - Winters, C AU - Reese, T Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Hippocampus KW - g-Aminobutyric acid KW - Tomography KW - Neurons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313046379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Electron+tomography+of+the+GABAergic+post-synaptic+density+in+dissociated+hippocampal+neurons&rft.au=Linsalata%2C+A%3BChen%2C+X%3BWinters%2C+C%3BReese%2C+T&rft.aulast=Linsalata&rft.aufirst=A&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Der+Pathologe&rft.issn=1432-1963&rft_id=info:doi/10.1007%2Fs00292-011-1475-6 L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - In-vivo optical measurement of direct- and indirect-pathway striatal neuron activity in mice performing an operant task T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313040826; 6104164 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Cui, G AU - Jun, S AU - Jin, X AU - Vogel, S AU - Lovinger, D AU - Costa, R Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Mice KW - Operant conditioning KW - Neostriatum KW - Neurons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313040826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=In-vivo+optical+measurement+of+direct-+and+indirect-pathway+striatal+neuron+activity+in+mice+performing+an+operant+task&rft.au=Cui%2C+G%3BJun%2C+S%3BJin%2C+X%3BVogel%2C+S%3BLovinger%2C+D%3BCosta%2C+R&rft.aulast=Cui&rft.aufirst=G&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - MEG reveals aberrant spontaneous, but not stimulus-dependant, neural synchrony in autism spectrum disorders T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313017031; 6106363 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Ghuman, A AU - Van Den Honert, R AU - Dixon, E AU - Robustelli, B AU - Wallace, G AU - Martin, A Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Autism KW - Magnetoencephalography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313017031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=MEG+reveals+aberrant+spontaneous%2C+but+not+stimulus-dependant%2C+neural+synchrony+in+autism+spectrum+disorders&rft.au=Ghuman%2C+A%3BVan+Den+Honert%2C+R%3BDixon%2C+E%3BRobustelli%2C+B%3BWallace%2C+G%3BMartin%2C+A&rft.aulast=Ghuman&rft.aufirst=A&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A Drosophila neuroligin regulates synaptic growth and function in response to activity and Phosphoinositide 3 kinase T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313015079; 6106078 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Mozer, B AU - Sandstrom, D Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - phosphoinositides KW - Synaptogenesis KW - Growth KW - Drosophila UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313015079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=A+Drosophila+neuroligin+regulates+synaptic+growth+and+function+in+response+to+activity+and+Phosphoinositide+3+kinase&rft.au=Mozer%2C+B%3BSandstrom%2C+D&rft.aulast=Mozer&rft.aufirst=B&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Gustatory interneurons in an insect respond to multiple tastants and with temporally complex firing patterns T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313014539; 6105762 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Reiter, S AU - Stopfer, M Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Insects KW - Firing pattern KW - Tastants KW - Interneurons KW - Aquatic insects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313014539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.atitle=super%2868%29Ga-DOTA-Affibody+molecule+for+in+vivo+assessment+of+HER2%2Fneu+expression+with+PET&rft.au=Kramer-Marek%2C+Gabriela%3BShenoy%2C+Nalini%3BSeidel%2C+Jurgen%3BGriffiths%2C+Gary+L%3BChoyke%2C+Peter%3BCapala%2C+Jacek&rft.aulast=Kramer-Marek&rft.aufirst=Gabriela&rft.date=2011-11-01&rft.volume=38&rft.issue=11&rft.spage=1967&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.issn=16197070&rft_id=info:doi/10.1007%2Fs00259-011-1810-4 L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Stress-induced modulation of glucocorticoid receptor expression in adult born neurons T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313012109; 6104985 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Carter, R AU - Cameron, H Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Neurons KW - Glucocorticoid receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313012109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Stress-induced+modulation+of+glucocorticoid+receptor+expression+in+adult+born+neurons&rft.au=Carter%2C+R%3BCameron%2C+H&rft.aulast=Carter&rft.aufirst=R&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - FGF8 expression is crucial for olfactory ensheathing cell development T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313011236; 6104928 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Forni, P AU - Bharti, K AU - Wray, S Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - olfactory ensheathing cells KW - Fibroblast growth factor 8 KW - Olfaction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313011236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=FGF8+expression+is+crucial+for+olfactory+ensheathing+cell+development&rft.au=Forni%2C+P%3BBharti%2C+K%3BWray%2C+S&rft.aulast=Forni&rft.aufirst=P&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Contribution of activity-dependent BDNF signaling to cortical slow-wave activity T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313008101; 6103481 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Hardy, N AU - Martinowich, K AU - Jimenez, D AU - Schloesser, R AU - Weinberger, D AU - Lu, B. Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Cortex KW - Brain-derived neurotrophic factor UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313008101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Contribution+of+activity-dependent+BDNF+signaling+to+cortical+slow-wave+activity&rft.au=Hardy%2C+N%3BMartinowich%2C+K%3BJimenez%2C+D%3BSchloesser%2C+R%3BWeinberger%2C+D%3BLu%2C+B.&rft.aulast=Hardy&rft.aufirst=N&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Neural correlates of bias towards neutral faces relative to fearful faces in healthy individuals T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313003701; 6102985 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Doty, T AU - Japee, S AU - Ingvar, M AU - Ungerleider, L Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Nervous system UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313003701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Neural+correlates+of+bias+towards+neutral+faces+relative+to+fearful+faces+in+healthy+individuals&rft.au=Doty%2C+T%3BJapee%2C+S%3BIngvar%2C+M%3BUngerleider%2C+L&rft.aulast=Doty&rft.aufirst=T&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Corticostriatal CB1 receptor modulation of goal-directed and habitual actions T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1312997244; 6104524 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Gremel, C AU - Luo, G AU - Lovinger, D AU - Costa, R Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Cortex KW - Cannabinoid CB1 receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312997244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Corticostriatal+CB1+receptor+modulation+of+goal-directed+and+habitual+actions&rft.au=Gremel%2C+C%3BLuo%2C+G%3BLovinger%2C+D%3BCosta%2C+R&rft.aulast=Gremel&rft.aufirst=C&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Oscillatory neural synchrony and information transmission rates in the insect olfactory system T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1312982907; 6105672 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Aldworth, Z AU - Stopfer, M Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Insects KW - Olfactory system KW - Information processing KW - Aquatic insects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312982907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Oscillatory+neural+synchrony+and+information+transmission+rates+in+the+insect+olfactory+system&rft.au=Aldworth%2C+Z%3BStopfer%2C+M&rft.aulast=Aldworth&rft.aufirst=Z&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Two critical and functionally distinct time periods for early face and body perception T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1312981569; 6105871 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Pitcher, D AU - Duchaine, B AU - Walsh, V AU - Kanwisher, N Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Perception KW - Face KW - Pattern recognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312981569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Two+critical+and+functionally+distinct+time+periods+for+early+face+and+body+perception&rft.au=Pitcher%2C+D%3BDuchaine%2C+B%3BWalsh%2C+V%3BKanwisher%2C+N&rft.aulast=Pitcher&rft.aufirst=D&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A-beta(1-42) impairs clearance of synapticallyreleased glutamate by the glial transporter GLT-1. T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1312977451; 6106345 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Scimemi, A AU - Meabon, J AU - Diamond, J AU - Cook, D Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Glutamic acid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312977451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=A-beta%281-42%29+impairs+clearance+of+synapticallyreleased+glutamate+by+the+glial+transporter+GLT-1.&rft.au=Scimemi%2C+A%3BMeabon%2C+J%3BDiamond%2C+J%3BCook%2C+D&rft.aulast=Scimemi&rft.aufirst=A&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Striosomal and extended striatal expression of the CB1 cannabinoid receptor during development and in the mature mouse T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1312973710; 6103355 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Davis, M AU - Lovinger, D Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Cannabinoid CB1 receptors KW - Neostriatum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312973710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Striosomal+and+extended+striatal+expression+of+the+CB1+cannabinoid+receptor+during+development+and+in+the+mature+mouse&rft.au=Davis%2C+M%3BLovinger%2C+D&rft.aulast=Davis&rft.aufirst=M&rft.date=2011-11-12&rft.volume=49&rft.issue=11&rft.spage=2820&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2011.07.067 L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Roles of inhibition of GSK-3 and HDACs in beneficial effects of combined lithium and valproate treatment in transgenic mouse models of Huntington's disease T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1312971326; 6106015 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Chiu, C AU - Liu, G AU - Leeds, P AU - Chuang, D Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Lithium KW - Animal models KW - Valproic acid KW - Histone deacetylase KW - Huntington's disease KW - Transgenic mice KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312971326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Roles+of+inhibition+of+GSK-3+and+HDACs+in+beneficial+effects+of+combined+lithium+and+valproate+treatment+in+transgenic+mouse+models+of+Huntington%27s+disease&rft.au=Chiu%2C+C%3BLiu%2C+G%3BLeeds%2C+P%3BChuang%2C+D&rft.aulast=Chiu&rft.aufirst=C&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Parallel changes in synaptic function and structural in the basal ganglia after chronic ethanol and cocaine exposure T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1312967887; 6105702 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Alvarez, V Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Ethanol KW - cocaine KW - Cocaine KW - Basal ganglia KW - Ganglia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312967887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Parallel+changes+in+synaptic+function+and+structural+in+the+basal+ganglia+after+chronic+ethanol+and+cocaine+exposure&rft.au=Alvarez%2C+V&rft.aulast=Alvarez&rft.aufirst=V&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Cytotoxicity of synthetic cannabinoids found in "Spice" products: The role of cannabinoid receptors and the caspase cascade in the NG 108-15 cell line AN - 902361862; 15784612 AB - The worldwide distribution of "Spice" that contains synthetic cannabinoids with a pharmacological activity similar to Delta 9-tetrahydrocannabinol has been reported. In the current study, we evaluated the cytotoxicity of the synthetic cannabinoids, CP-55,940, CP-47,497 and CP-47,497-C8 towards NG 108-15 cells and investigated their mechanism of cytotoxicity. CP-55,940, CP-47,497 and CP-47,497-C8 were all cytotoxic for NG 108-15 cells in a concentration-dependent manner. The cytotoxicity of these synthetic cannabinoids was suppressed by preincubation with the selective CB1 receptor antagonist AM251, but not with the selective CB2 receptor antagonist AM630. Preincubation with a caspase-3 inhibitor significantly suppressed the cytotoxicity of these synthetic cannabinoids for NG 108-15 cells. Induction of apoptosis by these cannabinoids was also confirmed by staining of the cells with annexin V. Our results indicate that the cytotoxicity of synthetic cannabinoids towards NG 108-15 cells is mediated by the CB1 receptor, but not by the CB2 receptor, and further suggest that caspase-cascades may play an important role in the apoptosis induced by these synthetic cannabinoids. JF - Toxicology Letters AU - Tomiyama, Kenichi AU - Funada, Masahiko AD - Department of Drug Dependence Research, National Institute of Mental Health. National Center of Neurology and Psychiatry, Japan, mfunada@ncnp.go.jp Y1 - 2011/11/10/ PY - 2011 DA - 2011 Nov 10 SP - 12 EP - 17 PB - Elsevier B.V., Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland VL - 207 IS - 1 SN - 0378-4274, 0378-4274 KW - Toxicology Abstracts KW - Annexin V KW - Cannabinoid CB2 receptors KW - X:24300 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902361862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Cytotoxicity+of+synthetic+cannabinoids+found+in+%22Spice%22+products%3A+The+role+of+cannabinoid+receptors+and+the+caspase+cascade+in+the+NG+108-15+cell+line&rft.au=Tomiyama%2C+Kenichi%3BFunada%2C+Masahiko&rft.aulast=Tomiyama&rft.aufirst=Kenichi&rft.date=2011-11-10&rft.volume=207&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2011.08.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Cannabinoid CB2 receptors DO - http://dx.doi.org/10.1016/j.toxlet.2011.08.021 ER - TY - JOUR T1 - Structural Insights into Ail-Mediated Adhesion in Yersinia pestis AN - 918057759; 16049336 AB - Ail is an outer membrane protein from Yersinia pestis that is highly expressed in a rodent model of bubonic plague, making it a good candidate for vaccine development. Ail is important for attaching to host cells and evading host immune responses, facilitating rapid progression of a plague infection. Binding to host cells is important for injection of cytotoxic Yersinia outer proteins. To learn more about how Ail mediates adhesion, we solved two high-resolution crystal structures of Ail, with no ligand bound and in complex with a heparin analog called sucrose octasulfate. We identified multiple adhesion targets, including laminin and heparin, and showed that a 40 kDa domain of laminin called LG4-5 specifically binds to Ail. We also evaluated the contribution of laminin to delivery of Yops to HEp-2 cells. This work constitutes a structural description of how a bacterial outer membrane protein uses a multivalent approach to bind host cells. JF - Structure AU - Yamashita, Satoshi AU - Lukacik, Petra AU - Barnard, Travis J AU - Noinaj, Nicholas AU - Felek, Suleyman AU - Tsang, Tiffany M AU - Krukonis, Eric S AU - Hinnebusch, BJoseph AU - Buchanan, Susan K AD - Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-8030, USA, skbuchan@helix.nih.gov Y1 - 2011/11/09/ PY - 2011 DA - 2011 Nov 09 SP - 1672 EP - 1682 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 United States VL - 19 IS - 11 SN - 0969-2126, 0969-2126 KW - Microbiology Abstracts B: Bacteriology KW - Laminin KW - outer membrane proteins KW - Animal models KW - Yersinia pestis KW - Infection KW - Cytotoxicity KW - Sucrose KW - Crystal structure KW - Plague KW - Vaccines KW - Immune response KW - Heparin KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918057759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Structure&rft.atitle=Structural+Insights+into+Ail-Mediated+Adhesion+in+Yersinia+pestis&rft.au=Yamashita%2C+Satoshi%3BLukacik%2C+Petra%3BBarnard%2C+Travis+J%3BNoinaj%2C+Nicholas%3BFelek%2C+Suleyman%3BTsang%2C+Tiffany+M%3BKrukonis%2C+Eric+S%3BHinnebusch%2C+BJoseph%3BBuchanan%2C+Susan+K&rft.aulast=Yamashita&rft.aufirst=Satoshi&rft.date=2011-11-09&rft.volume=19&rft.issue=11&rft.spage=1672&rft.isbn=&rft.btitle=&rft.title=Structure&rft.issn=09692126&rft_id=info:doi/10.1016%2Fj.str.2011.08.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Laminin; Cytotoxicity; outer membrane proteins; Sucrose; Animal models; Crystal structure; Immune response; Vaccines; Plague; Infection; Heparin; Yersinia pestis DO - http://dx.doi.org/10.1016/j.str.2011.08.010 ER - TY - JOUR T1 - An in vitro and in vivo study of a novel zinc complex, zinc N-(2-hydroxyacetophenone)glycinate to overcome multidrug resistance in cancer. AN - 898503909; 21717020 AB - Multiple drug resistance (MDR) remains a major clinical challenge for cancer treatment. P-glycoprotein is the major contributor and they exceed their role in the chemotherapy resistance of most of the malignancies. Attempts in several preclinical and clinical studies to reverse the MDR phenomenon by using MDR modulators have not yet generated promising results. In the present study, a co-ordination complex of zinc viz., Zn N-(2-hydroxyacetophenone)glycinate (ZnNG) has been synthesized, characterized and its antitumour activity was tested in vitro against drug sensitive and resistant human T-lymphoblastic leukemic cell lines (CCRF/CEM and CEM/ADR5000 respectively) and in vivo against Ehrlich ascites carcinoma (EAC) implanted in female Swiss albino mice. To evaluate the cytotoxic potential of ZnNG, we used sensitive CCRF/CEM and drug resistant CEM/ADR 5000 cell lines in vitro. Moreover, ZnNG also has the potential ability to reverse the multidrug resistance phenotype in drug resistant CEM/ADR 5000 cell line and induces apoptosis in combination with vinblastine. ZnNG remarkably increases the life span of Swiss albino mice bearing sensitive and doxorubicin resistant subline of EAC in presence and in absence of doxorubicin. In addition, intraperitoneal application of ZnNG in mice does not show any systemic toxicity in preliminary trials in normal mice. To conclude, a novel metal chelate of zinc viz., ZnNG, may be a promising therapeutic agent against sensitive as well as drug resistant cancers. JF - Dalton transactions (Cambridge, England : 2003) AU - Ghosh, Ruma Dey AU - Das, Satyajit AU - Ganguly, Avishek AU - Banerjee, Kaushik AU - Chakraborty, Paramita AU - Sarkar, Avijit AU - Chatterjee, Mitali AU - Nanda, Ashis AU - Pradhan, Kiran AU - Choudhuri, Soumitra K AD - Department of In Vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, 700 026, Kolkata, India. Y1 - 2011/11/07/ PY - 2011 DA - 2011 Nov 07 SP - 10873 EP - 10884 VL - 40 IS - 41 KW - Antineoplastic Agents KW - 0 KW - Coordination Complexes KW - P-Glycoprotein KW - Reactive Oxygen Species KW - Vinblastine KW - 5V9KLZ54CY KW - Doxorubicin KW - 80168379AG KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - Vinblastine -- pharmacology KW - Animals KW - Reactive Oxygen Species -- metabolism KW - Humans KW - Cell Line, Tumor KW - Mice KW - Carcinoma, Ehrlich Tumor KW - Zinc -- chemistry KW - Doxorubicin -- pharmacology KW - P-Glycoprotein -- genetics KW - P-Glycoprotein -- metabolism KW - Apoptosis -- drug effects KW - Female KW - Coordination Complexes -- chemical synthesis KW - Coordination Complexes -- pharmacology KW - Antineoplastic Agents -- chemical synthesis KW - Coordination Complexes -- chemistry KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- pharmacology KW - Drug Resistance, Neoplasm -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/898503909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dalton+transactions+%28Cambridge%2C+England+%3A+2003%29&rft.atitle=An+in+vitro+and+in+vivo+study+of+a+novel+zinc+complex%2C+zinc+N-%282-hydroxyacetophenone%29glycinate+to+overcome+multidrug+resistance+in+cancer.&rft.au=Ghosh%2C+Ruma+Dey%3BDas%2C+Satyajit%3BGanguly%2C+Avishek%3BBanerjee%2C+Kaushik%3BChakraborty%2C+Paramita%3BSarkar%2C+Avijit%3BChatterjee%2C+Mitali%3BNanda%2C+Ashis%3BPradhan%2C+Kiran%3BChoudhuri%2C+Soumitra+K&rft.aulast=Ghosh&rft.aufirst=Ruma&rft.date=2011-11-07&rft.volume=40&rft.issue=41&rft.spage=10873&rft.isbn=&rft.btitle=&rft.title=Dalton+transactions+%28Cambridge%2C+England+%3A+2003%29&rft.issn=1477-9234&rft_id=info:doi/10.1039%2Fc1dt10501a LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-02-10 N1 - Date created - 2011-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1039/c1dt10501a ER - TY - CPAPER T1 - Use of p16/ki67 Cytology to Detect Cervical Pre-cancer in a US Referral Population T2 - 59th Annual Scientific Meeting of the American Society of Cytopathology (ASC 2011) AN - 1313049676; 6068390 JF - 59th Annual Scientific Meeting of the American Society of Cytopathology (ASC 2011) AU - Wentzensen, Nicolas AU - Walker, Joan AU - Zuna, Rosemary AU - Dunn, Terence AU - Gold, Michael AU - Schiffman, Mark Y1 - 2011/11/04/ PY - 2011 DA - 2011 Nov 04 KW - Cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313049676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=59th+Annual+Scientific+Meeting+of+the+American+Society+of+Cytopathology+%28ASC+2011%29&rft.atitle=Use+of+p16%2Fki67+Cytology+to+Detect+Cervical+Pre-cancer+in+a+US+Referral+Population&rft.au=Wentzensen%2C+Nicolas%3BWalker%2C+Joan%3BZuna%2C+Rosemary%3BDunn%2C+Terence%3BGold%2C+Michael%3BSchiffman%2C+Mark&rft.aulast=Wentzensen&rft.aufirst=Nicolas&rft.date=2011-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Scientific+Meeting+of+the+American+Society+of+Cytopathology+%28ASC+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://cytopathologymeeting.org/2011/wp-content/uploads/2011/10/Final-Program1.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Spectrum of Cancer Risk Among US Solid Organ Transplant Recipients AN - 912920357; 16038381 AB - Context Solid organ transplant recipients have elevated cancer risk due to immunosuppression and oncogenic viral infections. Because most prior research has concerned kidney recipients, large studies that include recipients of differing organs can inform cancer etiology. OBJECTIVE: To describe the overall pattern of cancer following solid organ transplantion. Design, Setting, and Participants Cohort study using linked data on solid organ transplant recipients from the US Scientific Registry of Transplant Recipients (1987-2008) and 13 state and regional cancer registries. MAIN OUTCOME MEASURES: Standardized incidence ratios (SIRs) and excess absolute risks (EARs) assessing relative and absolute cancer risk in transplant recipients compared with the general population. RESULTS: The registry linkages yielded data on 175 732 solid organ transplants (58.4% for kidney, 21.6% for liver, 10.0% for heart, and 4.0% for lung). The overall cancer risk was elevated with 10 656 cases and an incidence of 1375 per 100 000 person-years (SIR, 2.10 [95% CI, 2.06-2.14]; EAR, 719.3 [95% CI, 693.3-745.6] per 100 000 person-years). Risk was increased for 32 different malignancies, some related to known infections (eg, anal cancer, Kaposi sarcoma) and others unrelated (eg, melanoma, thyroid and lip cancers). The most common malignancies with elevated risk were non-Hodgkin lymphoma (n = 1504; incidence: 194.0 per 100 000 person-years; SIR, 7.54 [95% CI, 7.17-7.93]; EAR, 168.3 [95% CI, 158.6-178.4] per 100 000 person-years) and cancers of the lung (n = 1344; incidence: 173.4 per 100 000 person-years; SIR, 1.97 [95% CI, 1.86-2.08]; EAR, 85.3 [95% CI, 76.2-94.8] per 100 000 person-years), liver (n = 930; incidence: 120.0 per 100 000 person-years; SIR, 11.56 [95% CI, 10.83-12.33]; EAR, 109.6 [95% CI, 102.0-117.6] per 100 000 person-years), and kidney (n = 752; incidence: 97.0 per 100 000 person-years; SIR, 4.65 [95% CI, 4.32-4.99]; EAR, 76.1 [95% CI, 69.3-83.3] per 100 000 person-years). Lung cancer risk was most elevated in lung recipients (SIR, 6.13 [95% CI, 5.18-7.21]) but also increased among other recipients (kidney: SIR, 1.46 [95% CI, 1.34-1.59]; liver: SIR, 1.95 [95% CI, 1.74-2.19]; and heart: SIR, 2.67 [95% CI, 2.40-2.95]). Liver cancer risk was elevated only among liver recipients (SIR, 43.83 [95% CI, 40.90-46.91]), who manifested exceptional risk in the first 6 months (SIR, 508.97 [95% CI, 474.16-545.66]) and a 2-fold excess risk for 10 to 15 years thereafter (SIR, 2.22 [95% CI, 1.57-3.04]). Among kidney recipients, kidney cancer risk was elevated (SIR, 6.66 [95% CI, 6.12-7.23]) and bimodal in onset time. Kidney cancer risk also was increased in liver recipients (SIR, 1.80 [95% CI, 1.40-2.29]) and heart recipients (SIR, 2.90 [95% CI, 2.32-3.59]). CONCLUSION: Compared with the general population, recipients of a kidney, liver, heart, or lung transplant have an increased risk for diverse infection-related and unrelated cancers. JF - JAMA: Journal of the American Medical Association AU - Engels, Eric A AU - Pfeiffer, Ruth M AU - Fraumeni, Joseph F AU - Kasiske, Bertram L AU - Israni, Ajay K AU - Snyder, Jon J AU - Wolfe, Robert A AU - Goodrich, Nathan P AU - Bayakly, ARana AU - Clarke, Christina A AU - Copeland, Glenn AU - Finch, Jack L AU - Fleissner, Mary Lou AU - Goodman, Marc T AU - Kahn, Amy AU - Koch, Lori AU - Lynch, Charles F AU - Madeleine, Margaret M AU - Pawlish, Karen AU - Rao, Chandrika AU - Williams, Melanie A AU - Castenson, David AU - Curry, Michael AU - Parsons, Ruth AU - Fant, Gregory AU - Lin, Monica AD - Author Affiliations: National Cancer Institute, Rockville, Maryland (Drs Engels, Pfeiffer, and Fraumeni) Y1 - 2011/11/02/ PY - 2011 DA - 2011 Nov 02 SP - 1891 EP - 1901 PB - American Medical Association, 515 N. State St. Chicago IL 60610 United States VL - 306 IS - 17 SN - 0098-7484, 0098-7484 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Thyroid KW - melanoma KW - Infection KW - Organs KW - Cancer KW - Melanoma KW - USA KW - Kidney KW - Liver KW - infection KW - Standards KW - Lung cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912920357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Spectrum+of+Cancer+Risk+Among+US+Solid+Organ+Transplant+Recipients&rft.au=Engels%2C+Eric+A%3BPfeiffer%2C+Ruth+M%3BFraumeni%2C+Joseph+F%3BKasiske%2C+Bertram+L%3BIsrani%2C+Ajay+K%3BSnyder%2C+Jon+J%3BWolfe%2C+Robert+A%3BGoodrich%2C+Nathan+P%3BBayakly%2C+ARana%3BClarke%2C+Christina+A%3BCopeland%2C+Glenn%3BFinch%2C+Jack+L%3BFleissner%2C+Mary+Lou%3BGoodman%2C+Marc+T%3BKahn%2C+Amy%3BKoch%2C+Lori%3BLynch%2C+Charles+F%3BMadeleine%2C+Margaret+M%3BPawlish%2C+Karen%3BRao%2C+Chandrika%3BWilliams%2C+Melanie+A%3BCastenson%2C+David%3BCurry%2C+Michael%3BParsons%2C+Ruth%3BFant%2C+Gregory%3BLin%2C+Monica&rft.aulast=Engels&rft.aufirst=Eric&rft.date=2011-11-02&rft.volume=306&rft.issue=17&rft.spage=1891&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2014-05-29 N1 - SubjectsTermNotLitGenreText - Thyroid; infection; Liver; Kidney; Standards; melanoma; Infection; Organs; Cancer; Melanoma; Lung cancer; USA ER - TY - JOUR T1 - Early-Life Exposures and Early-Onset Uterine Leiomyomata in Black Women in the Sister Study AN - 1008843703; 16537011 AB - Background: Uterine leiomyomata (fibroids) are hormonally responsive tumors, but little is known about risk factors. Early-life exposures may influence uterine development and subsequent response to hormones in adulthood. An earlier analysis of non-Hispanic white women who participated in the Sister Study found associations between several early-life factors and early-onset fibroids. Objectives: We evaluated associations of early-life and childhood exposures with early-onset fibroids among black women and compared the results with those found among white women. Methods: We analyzed baseline data from 3,534 black women, 35-59 years of age, in the Sister Study (a nationwide cohort of women who had a sister diagnosed with breast cancer) who self-reported information on early-life and childhood exposures. Early-onset fibroids were assessed based on self-report of a physician diagnosis of fibroids by the age of 30 years (n = 561). We estimated risk ratios (RR) and 95% confidence intervals (CI) from log-binomial regression models. Results: Factors most strongly associated with early-onset fibroids were in utero diethylstilbestrol (DES; RR = 2.02; 95% CI: 1.28, 3.18), maternal prepregnancy diabetes or gestational diabetes (RR = 1.54; 95% CI: 0.95, 2.49), and monozygotic multiple birth (RR = 1.94; 95% CI: 1.26, 2.99). We also found positive associations with having been taller or thinner than peers at the age of 10 years and with early-life factors that included being the firstborn child of a teenage mother, maternal hypertensive disorder, preterm birth, and having been fed soy formula. Conclusions: With the exception of monozygotic multiple birth and maternal hypertensive disorder, early-life risk factors for early-onset fibroids for black women were similar to those found for white women. However, in contrast to whites, childhood height and weight, but not low socioeconomic status indicators, were associated with early-onset fibroids in blacks. The general consistency of early-life findings for black and white women supports a possible role of early-life factors in fibroid development. JF - Environmental Health Perspectives AU - D'Aloisio, Aimee A AU - Baird, Donna D AU - DeRoo, Lisa A AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2011/11/02/ PY - 2011 DA - 2011 Nov 02 SP - 406 EP - 412 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 120 IS - 3 SN - 0091-6765, 0091-6765 KW - Toxicology Abstracts; Risk Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - diabetes mellitus KW - diethylstilbestrol KW - early-life KW - leiomyoma KW - multiple birth offspring KW - pregnancy KW - pregnancy-induced hypertension KW - prenatal exposure delayed effects KW - socioeconomic factors KW - soy formula KW - Age KW - tumors KW - Development KW - Hormones KW - Models KW - Risk factors KW - Regression analysis KW - Diethylstilbestrol KW - Adolescents KW - Uterus KW - Data processing KW - Tumors KW - Children KW - Cancer KW - Soybeans KW - Diabetes mellitus KW - Birth KW - Socio-economic aspects KW - Breast cancer KW - Females KW - X 24310:Pharmaceuticals KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1008843703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Early-Life+Exposures+and+Early-Onset+Uterine+Leiomyomata+in+Black+Women+in+the+Sister+Study&rft.au=D%27Aloisio%2C+Aimee+A%3BBaird%2C+Donna+D%3BDeRoo%2C+Lisa+A%3BSandler%2C+Dale+P&rft.aulast=D%27Aloisio&rft.aufirst=Aimee&rft.date=2011-11-02&rft.volume=120&rft.issue=3&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1103620 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Age; Uterus; Data processing; Development; Tumors; Children; Hormones; Soybeans; Models; Birth; Diabetes mellitus; Socio-economic aspects; Risk factors; Regression analysis; Breast cancer; Diethylstilbestrol; diabetes mellitus; tumors; Females; Cancer; Adolescents DO - http://dx.doi.org/10.1289/ehp.1103620 ER - TY - JOUR T1 - Optimal conditions for lentiviral transduction of engrafting human CD34 super(+) cells AN - 968168868; 16451699 AB - Cytokines are required for gamma -retroviral transduction of human CD34 super(+) cells. However, cytokines may reduce engraftment of CD34 super(+) cells and may not be necessary for their lentiviral transduction. We sought to optimize transduction and engraftment of human CD34 super(+) cells using lentiviral vectors. Single 24 h transduction of human CD34 super(+) cells with human immunodeficiency virus type 1 (HIV1)-based lentiviral vectors in media containing stem cell factor (SCF), FMS-like tyrosine kinase 3 (FLT3) ligand, thrombopoietin (each 100 ng ml super(-1)) and 10% fetal bovine serum was compared with various cytokine conditions during ex vivo culture and assayed using humanized xenograft mice for 6 months after transplantation. Serum-free media improved transduction efficiency of human CD34 super(+) cells. Interleukin-3 (20 ng ml super(-1)) had little effect on transduction efficiency or engraftment. Threefold higher cytokine mixture (each 300 ng ml super(-1)) reduced engraftment of CD34 super(+) cells. SCF alone (100 ng ml super(-1)) proved insufficient for maintaining engraftment ability and reduced transduction efficiency. Short-term prestimulation had little effect on transduction efficiency or engraftment, yet 24 h prestimulation showed higher transduction efficiency, higher gene expression levels and lower engraftment. In summary, 24 h prestimulation followed by single 24-h lentiviral transduction in serum-free media with SCF, FLT3 ligand and thrombopoietin yields high transduction efficiency to engrafting human CD34 super(+) cells, and is applicable in human clinical gene therapy trials. JF - Gene Therapy AU - Uchida, N AU - Hsieh, M M AU - Hayakawa, J AU - Madison, C AU - Washington, K N AU - Tisdale, J F AD - Molecular and Clinical Hematology Branch, National Heart Lung and Blood Institute (NHLBI)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD, USA Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1078 EP - 1086 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 18 IS - 11 SN - 0969-7128, 0969-7128 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - CD34 antigen KW - Cell culture KW - Clinical trials KW - Cytokines KW - FLT3L protein KW - Flt3 protein KW - Gene therapy KW - Interleukin 3 KW - Media (culture) KW - Stem cell factor KW - Thrombopoietin KW - Xenografts KW - Human immunodeficiency virus 1 KW - W 30905:Medical Applications KW - V 22360:AIDS and HIV KW - G 07760:Viruses & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968168868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Optimal+conditions+for+lentiviral+transduction+of+engrafting+human+CD34+super%28%2B%29+cells&rft.au=Uchida%2C+N%3BHsieh%2C+M+M%3BHayakawa%2C+J%3BMadison%2C+C%3BWashington%2C+K+N%3BTisdale%2C+J+F&rft.aulast=Uchida&rft.aufirst=N&rft.date=2011-11-01&rft.volume=18&rft.issue=11&rft.spage=1078&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2011.63 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2012-08-24 N1 - SubjectsTermNotLitGenreText - Gene therapy; Stem cell factor; Interleukin 3; Flt3 protein; FLT3L protein; Thrombopoietin; Cytokines; Cell culture; CD34 antigen; Xenografts; Clinical trials; Media (culture); Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1038/gt.2011.63 ER - TY - JOUR T1 - Clinical risk in paediatrics: Medicines AN - 964267926; 201206181 AB - The risk to children's health from medicines both prescribed and unprescribed is not insignificant and is probably greater than for adults. It arises from a long standing, and only recently rectified, lack of investment of research into the area of medicines for children, combined with the greater susceptibility of this age group to the effects of human error. This article explores some of the issues that contribute to this risk. Adapted from the source document. JF - Clinical Risk AU - Anderson, Mark AD - Consultant Paediatrician, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Trust, Queen Victoria Road, Newcastle upon Tyne, NEI 4LJ UK Mark.anderson7@nuth.nhs.uk Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 214 EP - 216 PB - Royal Society of Medicine Press Ltd, London UK VL - 17 IS - 6 SN - 1356-2622, 1356-2622 KW - Prescribed KW - Health KW - Children KW - Investment KW - Drugs KW - Susceptibility KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964267926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Risk&rft.atitle=Clinical+risk+in+paediatrics%3A+Medicines&rft.au=Anderson%2C+Mark&rft.aulast=Anderson&rft.aufirst=Mark&rft.date=2011-11-01&rft.volume=17&rft.issue=6&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Clinical+Risk&rft.issn=13562622&rft_id=info:doi/10.1258%2Fcr.2011.011044 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-04-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Drugs; Prescribed; Susceptibility; Investment; Children; Health DO - http://dx.doi.org/10.1258/cr.2011.011044 ER - TY - JOUR T1 - Serum total and HDL cholesterol and risk of prostate cancer AN - 926884750; 16351686 AB - Background: Studies suggest a decreased risk of high-grade prostate cancer in men with lower circulating total cholesterol and that statins may protect against aggressive disease. Confirmation in additional populations and examination of associations for lipoprotein subfractions are needed. Methods: We examined prostate cancer risk and serum total and HDL cholesterol in the ATBC Study cohort (n = 29,093). Cox proportional hazards models were used to estimate the relative risk of total (n = 2,041), non-aggressive (n = 829), aggressive (n = 461), advanced (n = 412), and high-grade (n = 231) prostate cancer by categories of total and HDL cholesterol. Results: After excluding the first 10 years of follow-up, men with higher serum total cholesterol were at increased risk of overall ( greater than or equal to 240 vs. <200 mg/dl: HR = 1.22, 95% CI 1.03-1.44, p-trend = 0 .01) and advanced ( greater than or equal to 240 vs. <200 mg/dl: HR = 1.85, 95% CI 1.13-3.03, p-trend = 0 .05) prostate cancer. Higher HDL cholesterol was suggestively associated with a decreased risk of prostate cancer regardless of stage or grade. Conclusions: In this population of smokers, high serum total cholesterol was associated with higher risk of advanced prostate cancer, and high HDL cholesterol suggestively reduced the risk of prostate cancer overall. These results support previous studies and, indirectly, support the hypothesis that statins may reduce the risk of advanced prostate cancer by lowering cholesterol. JF - Cancer Causes & Control AU - Mondul, Alison M AU - Weinstein, Stephanie J AU - Virtamo, Jarmo AU - Albanes, Demetrius AD - Department of Health and Human Services, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd. Ste. 320, Rockville, MD, 20852, USA, mondulam@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1545 EP - 1552 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 22 IS - 11 SN - 0957-5243, 0957-5243 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Cancer KW - Cholesterol KW - Prostate cancer KW - Risk reduction KW - Statins KW - cholesterol KW - prostate cancer KW - risk reduction KW - statins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926884750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Serum+total+and+HDL+cholesterol+and+risk+of+prostate+cancer&rft.au=Mondul%2C+Alison+M%3BWeinstein%2C+Stephanie+J%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius&rft.aulast=Mondul&rft.aufirst=Alison&rft.date=2011-11-01&rft.volume=22&rft.issue=11&rft.spage=1545&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9831-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - risk reduction; Statins; Prostate cancer; statins; Risk reduction; Cholesterol; prostate cancer; cholesterol; Cancer DO - http://dx.doi.org/10.1007/s10552-011-9831-7 ER - TY - JOUR T1 - LAURISTON S. TAYLOR LECTURE: RADIATION PROTECTION AND PUBLIC POLICY IN AN UNCERTAIN WORLD AN - 923208036; 16044257 AB - Ionizing radiation is a known, well-documented, and reasonably well-quantified human cancer risk factor based on a remarkably consistent body of dose-response information from epidemiological studies of exposed populations supported by experimental studies using animal and cellular models. This fact is largely ascribable to the relative ease, compared to other carcinogens, of estimating radiation dose to organs and local tissues. Statistical models for radiation-related cancer risk are increasingly relevant to both radiation protection policy and the adjudication of compensation claims for cancers diagnosed following occupational and environmental exposures to ionizing radiation, as discussed in a number of expert committee reports of national and international organizations concerned with radiation-related risks. These and other publications increasingly emphasize the relevance of well-quantified uncertainties in radiation-related risk projections, including upper and lower confidence or uncertainty bounds, for radiation protection. Finally, the wealth of detailed information provided by such quantitative uncertainty analysis approaches is highly relevant to radiation protection, which might be viewed as a political process that involves a diverse group of stakeholders who, individually, may be primarily concerned with avoiding possible radiation-related risks or with avoiding possibly unnecessary costs of risk reduction or unnecessary denial of benefits that require some radiation exposure, or with balancing both considerations to some degree. JF - Health Physics AU - Land, CE AD - Avenida de Saboia 914E, Apt. 4F, Monte Estoril 2765-579, Portugal, landc@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 499 EP - 508 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 101 IS - 5 SN - 0017-9078, 0017-9078 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Stakeholders KW - Politics KW - public policy KW - Risk reduction KW - Public policy KW - Organs KW - Cancer KW - risk reduction KW - Dose-response effects KW - Risk factors KW - Ionizing radiation KW - International organizations KW - international organizations KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/923208036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=LAURISTON+S.+TAYLOR+LECTURE%3A+RADIATION+PROTECTION+AND+PUBLIC+POLICY+IN+AN+UNCERTAIN+WORLD&rft.au=Land%2C+CE&rft.aulast=Land&rft.aufirst=CE&rft.date=2011-11-01&rft.volume=101&rft.issue=5&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0b013e318227e822 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Stakeholders; Politics; public policy; Risk reduction; Organs; Public policy; Cancer; risk reduction; Ionizing radiation; Risk factors; Dose-response effects; International organizations; international organizations DO - http://dx.doi.org/10.1097/HP.0b013e318227e822 ER - TY - JOUR T1 - Molecular differentiation of historic phage-type 80/81 and contemporary epidemic Staphylococcus aureus AN - 918060483; 16038754 AB - Staphylococcus aureus is a bacterial pathogen known to cause infections in epidemic waves. One such epidemic was caused by a clone known as phage-type 80/81, a penicillin-resistant strain that rose to world prominence in the late 1950s. The molecular underpinnings of the phage-type 80/81 outbreak have remained unknown for decades, nor is it understood why related S. aureus clones became epidemic in hospitals in the early 1990s. To better understand the molecular basis of these epidemics, we sequenced the genomes of eight S. aureus clinical isolates representative of the phage-type 80/81 clone, the Southwest Pacific clone [a community-associated methicillin-resistant S. aureus (MRSA) clone], and contemporary S. aureus clones, all of which are genetically related and belong to the same clonal complex (CC30). Genome sequence analysis revealed that there was coincident divergence of these clones from a recent common ancestor, a finding that resolves controversy about the evolutionary history of the lineage. Notably, we identified nonsynonymous SNPs in genes encoding accessory gene regulator C (agrC) and alpha -hemolysin (hla)-molecules important for S. aureus virulence-that were present in virtually all contemporary CC30 hospital isolates tested. Compared with the phage-type 80/81 and Southwest Pacific clones, contemporary CC30 hospital isolates had reduced virulence in mouse infection models, the result of SNPs in agrC and hla. We conclude that agr and hla (along with penicillin resistance) were essential for world dominance of phage-type 80/81 S. aureus, whereas key SNPs in contemporary CC30 clones restrict these pathogens to hospital settings in which the host is typically compromised. JF - Proceedings of the National Academy of Sciences, USA AU - DeLeo, Frank R AU - Kennedy, Adam D AU - Chen, Liang AU - Wardenburg, Juliane Bubeck AU - Kobayashi, Scott D AU - Mathema, Barun AU - Braughton, Kevin R AU - Whitney, Adeline R AU - Villaruz, Amer E AU - Martens, Craig A AU - Porcella, Stephen F AU - McGavin, Martin J AU - Otto, Michael AU - Musser, James M AU - Kreiswirth, Barry N AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840 Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 18091 EP - 18096 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 United States VL - 108 IS - 44 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology KW - Animal models KW - Clinical isolates KW - Differentiation KW - Dominance KW - Drug resistance KW - Epidemics KW - Evolution KW - Genomes KW - Histocompatibility antigen HLA KW - Hospitals KW - Infection KW - Nucleotide sequence KW - Pathogens KW - Penicillin KW - Single-nucleotide polymorphism KW - Virulence KW - Waves KW - Staphylococcus aureus KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918060483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Molecular+differentiation+of+historic+phage-type+80%2F81+and+contemporary+epidemic+Staphylococcus+aureus&rft.au=DeLeo%2C+Frank+R%3BKennedy%2C+Adam+D%3BChen%2C+Liang%3BWardenburg%2C+Juliane+Bubeck%3BKobayashi%2C+Scott+D%3BMathema%2C+Barun%3BBraughton%2C+Kevin+R%3BWhitney%2C+Adeline+R%3BVillaruz%2C+Amer+E%3BMartens%2C+Craig+A%3BPorcella%2C+Stephen+F%3BMcGavin%2C+Martin+J%3BOtto%2C+Michael%3BMusser%2C+James+M%3BKreiswirth%2C+Barry+N&rft.aulast=DeLeo&rft.aufirst=Frank&rft.date=2011-11-01&rft.volume=108&rft.issue=44&rft.spage=18091&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Genomes; Clinical isolates; Epidemics; Nucleotide sequence; Drug resistance; Animal models; Pathogens; Infection; Penicillin; Dominance; Virulence; Differentiation; Single-nucleotide polymorphism; Waves; Evolution; Hospitals; Staphylococcus aureus ER - TY - JOUR T1 - On the Pitfalls of Adjusting for Gestational Age at Birth AN - 918053278; 16099566 AB - Preterm delivery is a powerful predictor of newborn morbidity and mortality. Such problems are due to not only immaturity but also the pathologic factors (such as infection) that cause early delivery. The understanding of these underlying pathologic factors is incomplete at best. To the extent that unmeasured pathologies triggering preterm delivery also directly harm the fetus, they will confound the association of early delivery with neonatal outcomes. This, in turn, complicates studies of newborn outcomes more generally. When investigators analyze the association of risk factors with neonatal outcomes, adjustment for gestational age as a mediating variable will lead to bias. In the language of directed acyclic graphs, gestational age is a collider. The theoretical basis for colliders has been well described, and gestational age has recently been acknowledged as a possible collider. However, the impact of this problem, as well as its implications for perinatal research, has not been fully appreciated. The authors discuss the evidence for confounding and present simulations to explore how much bias is produced by adjustments for gestational age when estimating direct effects. Under plausible conditions, frank reversal of exposure-outcome associations can occur. When the purpose is causal inference, there are few settings in which adjustment for gestational age can be justified. JF - American Journal of Epidemiology AU - Wilcox, Allen J AU - Weinberg, Clarice R AU - Basso, Olga Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 1062 EP - 1068 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 174 IS - 9 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - Mortality KW - Age KW - Pathology KW - Risk factors KW - infection KW - Simulation KW - Neonates KW - Morbidity KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918053278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=On+the+Pitfalls+of+Adjusting+for+Gestational+Age+at+Birth&rft.au=Wilcox%2C+Allen+J%3BWeinberg%2C+Clarice+R%3BBasso%2C+Olga&rft.aulast=Wilcox&rft.aufirst=Allen&rft.date=2011-11-01&rft.volume=174&rft.issue=9&rft.spage=1062&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwr230 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - Mortality; Age; Pathology; Risk factors; infection; Simulation; Neonates; Morbidity DO - http://dx.doi.org/10.1093/aje/kwr230 ER - TY - JOUR T1 - Prospective Study of Alcohol Consumption Quantity and Frequency and Cancer-Specific Mortality in the US Population AN - 918053268; 16099564 AB - Prospective associations between quantity and frequency of alcohol consumption and cancer-specific mortality were studied using a nationally representative sample with pooled data from the 1988, 1990, 1991, and 1997-2004 administrations of the National Health Interview Survey (n = 323,354). By 2006, 8,362 participants had died of cancer. Cox proportional hazards regression was used to estimate relative risks. Among current alcohol drinkers, for all-site cancer mortality, higher-quantity drinking ( greater than or equal to 3 drinks on drinking days vs. 1 drink on drinking days) was associated with increased risk among men (relative risk (RR) = 1.24, 95% confidence interval (CI): 1.09, 1.41; P for linear trend = 0.001); higher-frequency drinking ( greater than or equal to 3 days/week vs. <1 day/week) was associated with increased risk among women (RR = 1.32, 95% CI: 1.13, 1.55; P-trend < 0.001). Lung cancer mortality results were similar, but among never smokers, results were null. For colorectal cancer mortality, higher-quantity drinking was associated with increased risk among women (RR = 1.93, 95% CI: 1.17, 3.18; P-trend = 0.03). Higher-frequency drinking was associated with increased risk of prostate cancer (RR = 1.55, 95% CI: 1.01, 2.38; P for quadratic effect = 0.03) and tended to be associated with increased risk of breast cancer (RR = 1.44, 95% CI: 0.96, 2.17; P-trend = 0.06). Epidemiologic studies of alcohol and cancer mortality should consider the independent effects of quantity and frequency. JF - American Journal of Epidemiology AU - Breslow, Rosalind A AU - Chen, Chiung M AU - Graubard, Barry I AU - Mukamal, Kenneth J Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 1044 EP - 1053 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 174 IS - 9 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Alcohol KW - USA KW - colorectal carcinoma KW - Breast cancer KW - prostate cancer KW - Lung cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918053268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Prospective+Study+of+Alcohol+Consumption+Quantity+and+Frequency+and+Cancer-Specific+Mortality+in+the+US+Population&rft.au=Breslow%2C+Rosalind+A%3BChen%2C+Chiung+M%3BGraubard%2C+Barry+I%3BMukamal%2C+Kenneth+J&rft.aulast=Breslow&rft.aufirst=Rosalind&rft.date=2011-11-01&rft.volume=174&rft.issue=9&rft.spage=1044&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwr210 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - Alcohol; Mortality; colorectal carcinoma; Breast cancer; prostate cancer; Lung cancer; USA DO - http://dx.doi.org/10.1093/aje/kwr210 ER - TY - JOUR T1 - AGA President's Symposium 2011: The Application of Genomics to Biodiversity AN - 918052373; 16141406 JF - Journal of Heredity AU - Johnson, Warren E AU - Hendrickson, Sher L AD - From the Laboratory of Genomic Diversity, National Cancer Institute, NCI-Frederick, Frederick, MD 21702, warjohns@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 782 EP - 783 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 102 IS - 6 SN - 0022-1503, 0022-1503 KW - Ecology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918052373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Heredity&rft.atitle=AGA+President%27s+Symposium+2011%3A+The+Application+of+Genomics+to+Biodiversity&rft.au=Johnson%2C+Warren+E%3BHendrickson%2C+Sher+L&rft.aulast=Johnson&rft.aufirst=Warren&rft.date=2011-11-01&rft.volume=102&rft.issue=6&rft.spage=782&rft.isbn=&rft.btitle=&rft.title=Journal+of+Heredity&rft.issn=00221503&rft_id=info:doi/10.1093%2Fjhered%2Fesr106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2014-04-17 DO - http://dx.doi.org/10.1093/jhered/esr106 ER - TY - JOUR T1 - Capsular polysaccharide vaccine for Group B Neisseria meningitidis, Escherichia coli K1, and Pasteurella haemolytica A2 AN - 918050651; 16038792 AB - We reviewed the literature that is the basis for our proposal that (2 arrow right 8)- alpha -Neu5Ac conjugates will be safe and effective vaccines for Group B meningococci (GBMs), Escherichia coli K1, and Pasteurella haemolytica A2. Although (2 arrow right 8)- alpha -Neu5Ac is a virulence factor and a protective antigen of these three pathogens, it is also a component of normal tissues (neural cell adhesion molecule). Natural, anti-(2 arrow right 8)- alpha -Neu5Ac present in most adults, vaccine-induced antibodies, and even high levels of spontaneously appearing monoclonal anti-(2 arrow right 8)- alpha -Neu5Ac did not cause autoimmunity. Although it is not possible to prove a null hypothesis, there are no epidemiologic, serologic, immunologic, or clinical data to indicate that (2 arrow right 8)- alpha -Neu5Ac antibodies will induce pathology or an autoimmune disease. No increased pathology caused by these antibodies was found, even in neonates and infants of mothers recovered from GBM meningitis. The lack of pathology mediated by anti-(2 arrow right 8)- alpha -Neu5Ac may be explained by different presentations of (2 arrow right 8)- alpha -Neu5Ac on bacterial and mammalian cells and by the unusual physicochemical properties of anti-(2 arrow right 8)- alpha -Neu5Ac. Based on clinical and experimental data collected over 30 y and because (2 arrow right 8)- alpha -Neu5Ac is an essential virulence factor and a protective antigen for GBM, E. coli K1, and P. haemolytica A2, protein conjugates of it are easy to prepare using inexpensive and plentiful ingredients, and they would be compatible with routinely administered infant vaccines, clinical studies of these conjugates should proceed. JF - Proceedings of the National Academy of Sciences, USA AU - Robbins, John B AU - Schneerson, Rachel AU - Xie, Guilin AU - Aake-Hanson, Lars AU - Miller, Mark A AD - Eunice Kennedy Shriver, National Institute of Child Health and Human Development, Bethesda, MD 20892 Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 17871 EP - 17875 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 United States VL - 108 IS - 44 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Antibodies KW - Autoimmune diseases KW - Capsular polysaccharides KW - Data processing KW - Infants KW - Mammalian cells KW - Meningitis KW - Neonates KW - Neural cell adhesion molecule KW - Pathogens KW - Physicochemical properties KW - Reviews KW - Vaccines KW - protective antigen KW - virulence factors KW - Neisseria meningitidis KW - Mannheimia haemolytica KW - Escherichia coli KW - F 06930:Autoimmunity KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918050651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Capsular+polysaccharide+vaccine+for+Group+B+Neisseria+meningitidis%2C+Escherichia+coli+K1%2C+and+Pasteurella+haemolytica+A2&rft.au=Robbins%2C+John+B%3BSchneerson%2C+Rachel%3BXie%2C+Guilin%3BAake-Hanson%2C+Lars%3BMiller%2C+Mark+A&rft.aulast=Robbins&rft.aufirst=John&rft.date=2011-11-01&rft.volume=108&rft.issue=44&rft.spage=17871&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Data processing; virulence factors; Autoimmune diseases; protective antigen; Physicochemical properties; Pathogens; Meningitis; Neural cell adhesion molecule; Antibodies; Mammalian cells; Reviews; Vaccines; Neonates; Capsular polysaccharides; Infants; Mannheimia haemolytica; Escherichia coli; Neisseria meningitidis ER - TY - JOUR T1 - Comparing cognitive interviewing and psychometric methods to evaluate a racial/ethnic discrimination scale AN - 916508562; 4260702 AB - Proponents of survey evaluation have long advocated the integration of qualitative and quantitative methodologies, but this recommendation has rarely been practiced. The authors used both methods to evaluate the "Everyday Discrimination" scale (EDS), which measures frequency of various types of discrimination, in a multiethnic population. Cognitive testing included 30 participants of various race/ethnic backgrounds and identified items that were redundant, unclear, or inconsistent (e.g., cognitive challenges in quantifying acts of discrimination). Psychometric analysis included secondary data from two national studies, including 570 Asian Americans, 366 Latinos, and 2,884 African Americans, and identified redundant items as well as those exhibiting differential item functioning (DIF) by race/ethnicity. Overall, qualitative and quantitative techniques complemented one another, as cognitive interviewing findings provided context and explanation for quantitative results. Researchers should consider further how to integrate these methods into instrument pretesting as a way to minimize response bias for ethnic and racial respondents in population-based surveys. Reprinted by permission of Sage Publications Inc. JF - Field methods AU - Reeve, Bryce B AU - Willis, Gordon AU - Shariff-Marco, Salma N AU - Breen, Nancy AU - Williams, David R AU - Gee, Gilbert C AU - Alegría, Margarita AU - Takeuchi, David T AU - Stapleton, Martha AU - Levin, Kerry Y AD - University of North Carolina, Chapel Hill ; National Institutes of Health, Bethesda ; Cancer Prevention Institute of California ; Harvard University ; University of California, Los Angeles ; University of Washington ; Westat Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 397 EP - 419 VL - 23 IS - 4 SN - 1525-822X, 1525-822X KW - Sociology KW - Evaluation KW - Comparative analysis KW - Racial discrimination KW - Ethnicity KW - Discrimination KW - African-Americans KW - U.S.A. KW - Psychometrics KW - Cognition KW - Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/916508562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Field+methods&rft.atitle=Comparing+cognitive+interviewing+and+psychometric+methods+to+evaluate+a+racial%2Fethnic+discrimination+scale&rft.au=Reeve%2C+Bryce+B%3BWillis%2C+Gordon%3BShariff-Marco%2C+Salma+N%3BBreen%2C+Nancy%3BWilliams%2C+David+R%3BGee%2C+Gilbert+C%3BAlegr%C3%ADa%2C+Margarita%3BTakeuchi%2C+David+T%3BStapleton%2C+Martha%3BLevin%2C+Kerry+Y&rft.aulast=Reeve&rft.aufirst=Bryce&rft.date=2011-11-01&rft.volume=23&rft.issue=4&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Field+methods&rft.issn=1525822X&rft_id=info:doi/10.1177%2F1525822X11416564 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3612 3549 2688 2449 10404; 10408 10404; 2449 10404; 2630 971; 7994; 4551; 4435; 10566 3612 3549 2688 2449 10404; 635 1656 10555 6091 961 636 4424; 433 293 14 DO - http://dx.doi.org/10.1177/1525822X11416564 ER - TY - JOUR T1 - Persistent distress after psychological exposure to the Nagasaki atomic bomb explosion AN - 914791144; 201200467 AB - Background: Although there is speculation that individuals living in the vicinity of nuclear disasters have persistent mental health deterioration due to psychological stress, few attempts have been made to examine this issue. Aims: To determine whether having been in the vicinity of the Nagasaki atomic bomb explosion in the absence of substantial exposure to radiation affected the mental health of local inhabitants more than half a century later. Method: Participants were randomly recruited from individuals who lived in the vicinity of the atomic bomb explosion in uncontaminated suburbs of Nagasaki. This sample (n = 347) was stratified by gender, age, perception of the explosion and current district of residence. Controls (n = 288) were recruited from among individuals who had moved into the area from outside Nagasaki 5-15 years after the bombing, matched for gender, age and district of residence. The primary outcome measure was the proportion of those at high risk of mental disorder based on the 28-item version of the General Health Questionnaire, with a cut-off point of 5/6. Other parameters related to individual perception of the explosion, health status, life events and habits were also assessed. Results: Having been in the vicinity of the explosion was the most significant factor (OR = 5.26, 95% CI 2.56-11.11) contributing to poorer mental health; erroneous knowledge of radiological hazard showed a mild association. In the sample group, anxiety after learning of the potential radiological hazard was significantly correlated with poor mental health (P<0.05), whereas anxiety about the explosion, or the degree of perception of it, was not; 74.5% of the sample group believed erroneously that the flash of the explosion was synonymous with radiation. Conclusions: Having been in the vicinity of the atomic bomb explosion without radiological exposure continued to be associated with poorer mental health more than half a century after the event. Fear on learning about the potential radiological hazard and lack of knowledge about radiological risk are responsible for this association. Adapted from the source document. JF - The British Journal of Psychiatry AU - Kim, Yoshiharu AU - Tsutsumi, Atsuro AU - Izutsu, Takashi AU - Kawamura, Noriyuki AU - Miyazaki, Takao AU - Kikkawa, Takehiko AD - Department of Adult Mental Health, National Institute of Mental Health, National Centre of Neurology and Psychiatry, 1-4-4 Ogawa Higashi Cho, Kodaira, Tokyo 187-8553, Japan kim@ncnp.go.jp Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 411 EP - 416 PB - Royal College of Psychiatrists, London UK VL - 199 IS - 5 SN - 0007-1250, 0007-1250 KW - Hazards KW - Learning KW - Gender KW - Mental health KW - Bombs KW - Explosions KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/914791144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+Journal+of+Psychiatry&rft.atitle=Persistent+distress+after+psychological+exposure+to+the+Nagasaki+atomic+bomb+explosion&rft.au=Kim%2C+Yoshiharu%3BTsutsumi%2C+Atsuro%3BIzutsu%2C+Takashi%3BKawamura%2C+Noriyuki%3BMiyazaki%2C+Takao%3BKikkawa%2C+Takehiko&rft.aulast=Kim&rft.aufirst=Yoshiharu&rft.date=2011-11-01&rft.volume=199&rft.issue=5&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Psychiatry&rft.issn=00071250&rft_id=info:doi/10.1192%2Fbjp.bp.110.085472 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-01-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BJPYAJ N1 - SubjectsTermNotLitGenreText - Explosions; Mental health; Bombs; Hazards; Gender; Learning DO - http://dx.doi.org/10.1192/bjp.bp.110.085472 ER - TY - JOUR T1 - Phase I trial of adoptive cell transfer with mixed-profile type-I/type-II allogeneic T cells for metastatic breast cancer. AN - 911925000; 21948234 AB - Metastatic breast cancer (MBC) response to allogeneic lymphocytes requires donor T-cell engraftment and is limited by graft-versus-host disease (GVHD). In mice, type-II-polarized T cells promote engraftment and modulate GVHD, whereas type-I-polarized T cells mediate more potent graft-versus-tumor (GVT) effects. This phase I translational study evaluated adoptive transfer of ex vivo costimulated type-I/type-II (T1/T2) donor T cells with T-cell-depleted (TCD) allogeneic stem cell transplantation (AlloSCT) for MBC. Patients had received anthracycline, taxane, and antibody therapies, and been treated for metastatic disease and a human leukocyte antigen (HLA)-identical-sibling donor. Donor lymphocytes were costimulated ex vivo with anti-CD3/anti-CD28 antibody-coated magnetic beads in interleukin (IL)-2/IL-4-supplemented media. Patients received reduced intensity conditioning, donor stem cells and T1/T2 cells, and monitoring for toxicity, engraftment, GVHD, and tumor response; results were compared with historical controls, identically treated except for T1/T2 product infusions. Mixed type-I/type-II CD4(+) T cells predominated in T1/T2 products. Nine patients received T1/T2 cells at dose level 1 (5 × 10(6) cells/kg). T-cell donor chimerism reached 100% by a median of 28 days. Seven (78%) developed acute GVHD. At day +28, five patients had partial responses (56%) and none had MBC progression; thereafter, two patients had continued responses. Donor T-cell engraftment and tumor responses appeared faster than in historical controls, but GVHD rates were similar and responders progressed early, often following treatment of acute GVHD. Allogeneic T1/T2 cells were safely infused with TCD-AlloSCT, appeared to promote donor engraftment, and may have contributed to transient early tumor responses. ©2011 AACR JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Hardy, Nancy M AU - Mossoba, Miriam E AU - Steinberg, Seth M AU - Fellowes, Vicki AU - Yan, Xiao-Yi AU - Hakim, Frances T AU - Babb, Rebecca R AU - Avila, Daniele AU - Gea-Banacloche, Juan AU - Sportès, Claude AU - Levine, Bruce L AU - June, Carl H AU - Khuu, Hahn M AU - Carpenter, Ashley E AU - Krumlauf, Michael C AU - Dwyer, Andrew J AU - Gress, Ronald E AU - Fowler, Daniel H AU - Bishop, Michael R AD - Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. hardyn@mail.nih.gov Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 6878 EP - 6887 VL - 17 IS - 21 SN - 1078-0432, 1078-0432 KW - Index Medicus KW - Graft vs Tumor Effect -- immunology KW - Humans KW - Adult KW - Neoplasm Metastasis KW - Middle Aged KW - Stem Cell Transplantation KW - Female KW - Breast Neoplasms -- immunology KW - Breast Neoplasms -- pathology KW - Breast Neoplasms -- therapy KW - Immunotherapy, Adoptive -- methods KW - Breast Neoplasms -- surgery KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911925000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Phase+I+trial+of+adoptive+cell+transfer+with+mixed-profile+type-I%2Ftype-II+allogeneic+T+cells+for+metastatic+breast+cancer.&rft.au=Hardy%2C+Nancy+M%3BMossoba%2C+Miriam+E%3BSteinberg%2C+Seth+M%3BFellowes%2C+Vicki%3BYan%2C+Xiao-Yi%3BHakim%2C+Frances+T%3BBabb%2C+Rebecca+R%3BAvila%2C+Daniele%3BGea-Banacloche%2C+Juan%3BSport%C3%A8s%2C+Claude%3BLevine%2C+Bruce+L%3BJune%2C+Carl+H%3BKhuu%2C+Hahn+M%3BCarpenter%2C+Ashley+E%3BKrumlauf%2C+Michael+C%3BDwyer%2C+Andrew+J%3BGress%2C+Ronald+E%3BFowler%2C+Daniel+H%3BBishop%2C+Michael+R&rft.aulast=Hardy&rft.aufirst=Nancy&rft.date=2011-11-01&rft.volume=17&rft.issue=21&rft.spage=6878&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-11-1579 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-20 N1 - Date created - 2011-11-02 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00082953; ClinicalTrials.gov N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] Cytotherapy. 2011 Jan;13(1):98-107 [20849361] Biol Blood Marrow Transplant. 2002;8(7):351-9 [12171481] Cytotherapy. 2002;4(5):429-30 [12473212] Blood. 2003 Nov 1;102(9):3439-46 [12855580] Cell. 2004 Apr 16;117(2):265-77 [15084263] Br J Haematol. 2004 Sep;126(6):837-43 [15352988] Blood. 2004 Oct 1;104(7):2187-93 [15172973] J Clin Oncol. 2004 Oct 1;22(19):3886-92 [15314059] Lancet. 1987 Jul 25;2(8552):175-8 [2885638] Ann Intern Med. 1988 Jun;108(6):806-14 [3285744] Bone Marrow Transplant. 1989 May;4(3):247-54 [2659110] Cancer Treat Res. 1990;50:99-111 [1976361] Blood. 1994 Nov 15;84(10):3540-9 [7949109] Bone Marrow Transplant. 1995 Jun;15(6):825-8 [7581076] Blood. 1996 Aug 15;88(4):1501-8 [8695872] J Immunol. 1996 Dec 1;157(11):4811-21 [8943383] Biol Blood Marrow Transplant. 1996 Oct;2(3):118-25 [9199754] J Clin Oncol. 1998 Mar;16(3):986-93 [9508181] Cytokines Cell Mol Ther. 1998 Mar;4(1):1-6 [9557210] Vox Sang. 1998;74 Suppl 2:331-40 [9704464] J Hematother. 1998 Oct;7(5):437-48 [9829318] Lancet. 2005 Jul 23-29;366(9482):318-20 [16039336] J Immunol. 2005 Nov 1;175(9):5732-43 [16237064] Biol Blood Marrow Transplant. 2005 Dec;11(12):945-56 [16338616] Blood. 2006 Feb 15;107(4):1325-31 [16269610] Annu Rev Immunol. 2006;24:147-74 [16551246] Clin Breast Cancer. 2006 Apr;7(1):87-9 [16764750] Blood. 2006 Jul 1;108(1):390-9 [16522809] Biol Blood Marrow Transplant. 2006 Sep;12(9):905-18 [16920556] Biol Blood Marrow Transplant. 2006 Nov;12(11):1150-60 [17085308] J Immunol. 2007 Apr 1;178(7):4222-9 [17371978] Biol Blood Marrow Transplant. 2007 Sep;13(9):1022-30 [17697964] Cancer. 2007 Sep 1;110(5):973-9 [17647245] J Immunol. 2008 Jan 1;180(1):89-105 [18097008] Bone Marrow Transplant. 2008 Mar;41(6):537-45 [18084340] Bone Marrow Transplant. 2009 Jul;44(2):81-7 [19448681] Immunol Cell Biol. 2010 Mar-Apr;88(3):250-6 [20065995] Curr Mol Med. 2010 Nov;10(8):719-26 [20937023] Leuk Lymphoma. 2000 Jul;38(3-4):221-34 [10830730] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/1078-0432.CCR-11-1579 ER - TY - JOUR T1 - Suppressed Type 1, Type 2, and Type 17 Cytokine Responses in Active Tuberculosis in Children AN - 911162780; 16062948 AB - Type 1 cytokine responses are known to play an important role in immunity to tuberculosis (TB) in children, although little is known about other factors that might be important. In addition, children are more prone to developing extrapulmonary manifestations of TB than adults. To identify the immune responses important both in control of infection and in extrapulmonary dissemination, we examined mycobacterium-specific cytokine responses of children with pulmonary TB (PTB) and extrapulmonary TB (ETB) and compared them with those of healthy control children (HC). No significant differences were found in the cytokine responses either with no stimulation or following mycobacterial-antigen (Ag) stimulation between children with PTB and ETB. On the other hand, children with active TB compared with HC showed markedly diminished production of type 1 (gamma interferon [IFN-] and tumor necrosis factor alpha [TNF-?]), 2 (interleukin 4 [IL-4] and IL-13), and 17 (IL-17A, IL-21, and IL-23)-associated cytokines with no stimulation and in response to mycobacterial antigens. This was not associated with significantly altered production of IL-10 or transforming growth factor ? (TGF-?). Among children with ETB, those with neurologic involvement exhibited more significantly diminished Ag-driven IFN- and IL-17 production. Pediatric TB is characterized by diminished type 1, 2, and 17 cytokine responses, with the most profound diminution favoring development of neurologic TB, suggesting a crucial role for these cytokines in protection against pediatric tuberculosis. JF - Clinical and Vaccine Immunology AU - Kumar, NPavan AU - Anuradha, R AU - Suresh, R AU - Ganesh, R AU - Shankar, Janani AU - Kumaraswami, V AU - Nutman, Thomas B AU - Babu, Subash AD - National Institutes of Health International Center for Excellence in Research, Chennai, India, sbabu@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1856 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 18 IS - 11 SN - 1556-679X, 1556-679X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Transforming growth factor KW - gamma -Interferon KW - Interleukin 4 KW - Mycobacterium KW - Pediatrics KW - Immunity KW - Infection KW - Children KW - Interleukin 21 KW - Interleukin 10 KW - Interferon KW - Interleukin 13 KW - Lung KW - Interleukin 17 KW - Cytokines KW - Tuberculosis KW - Immune response KW - Tumor necrosis factor- alpha KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911162780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Suppressed+Type+1%2C+Type+2%2C+and+Type+17+Cytokine+Responses+in+Active+Tuberculosis+in+Children&rft.au=Kumar%2C+NPavan%3BAnuradha%2C+R%3BSuresh%2C+R%3BGanesh%2C+R%3BShankar%2C+Janani%3BKumaraswami%2C+V%3BNutman%2C+Thomas+B%3BBabu%2C+Subash&rft.aulast=Kumar&rft.aufirst=NPavan&rft.date=2011-11-01&rft.volume=18&rft.issue=11&rft.spage=1856&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.05366-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Transforming growth factor; Interleukin 4; Pediatrics; Immunity; Interleukin 21; Children; Infection; Interleukin 10; Interferon; Interleukin 13; Lung; Interleukin 17; Cytokines; Tuberculosis; Tumor necrosis factor- alpha; Immune response; Mycobacterium DO - http://dx.doi.org/10.1128/CVI.05366-11 ER - TY - JOUR T1 - Pore water transport of enterococci out of beach sediments AN - 911154153; 15937003 AB - Enterococci are used to evaluate the safety of beach waters and studies have identified beach sands as a source of these bacteria. In order to study and quantify the release of microbes from beach sediments, flow column systems were built to evaluate flow of pore water out of beach sediments. Results show a peak in enterococci (average of 10% of the total microbes in core) released from the sand core within one pore water volume followed by a marked decline to below detection. These results indicate that few enterococci are easily removed and that factors other than simple pore water flow control the release of the majority of enterococci within beach sediments. A significantly larger quantity and release of enterococci were observed in cores collected after a significant rain event suggesting the influx of fresh water can alter the release pattern as compared to cores with no antecedent rainfall. JF - Marine Pollution Bulletin AU - Phillips, Matthew C AU - Solo-Gabriele, Helena M AU - Reniers, AJHM AU - Wang, John D AU - Kiger, Russell T AU - Abdel-Mottaleb, Noha AD - University of Miami, NSF NIEHS Oceans and Human Health Center, Miami, FL 33149, USA, hmsolo@miami.edu Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 2293 EP - 2298 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 62 IS - 11 SN - 0025-326X, 0025-326X KW - ASFA Marine Biotechnology Abstracts; Microbiology Abstracts B: Bacteriology; Environment Abstracts; Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Aqualine Abstracts; Water Resources Abstracts; Pollution Abstracts KW - Water Pollution KW - Pore water KW - Sediment gravity flows KW - Rainfall KW - Cores KW - Sand KW - Sediment Transport KW - Marine KW - Beaches KW - Freshwater environments KW - Interstitial Water KW - Sediments KW - Marine pollution KW - Rain KW - Flow Control KW - AQ 00001:Water Resources and Supplies KW - SW 3040:Wastewater treatment processes KW - Q4 27750:Environmental KW - O 4080:Pollution - Control and Prevention KW - P 1000:MARINE POLLUTION KW - Q5 08502:Methods and instruments KW - ENA 12:Oceans & Estuaries KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911154153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Pollution+Bulletin&rft.atitle=Pore+water+transport+of+enterococci+out+of+beach+sediments&rft.au=Phillips%2C+Matthew+C%3BSolo-Gabriele%2C+Helena+M%3BReniers%2C+AJHM%3BWang%2C+John+D%3BKiger%2C+Russell+T%3BAbdel-Mottaleb%2C+Noha&rft.aulast=Phillips&rft.aufirst=Matthew&rft.date=2011-11-01&rft.volume=62&rft.issue=11&rft.spage=2293&rft.isbn=&rft.btitle=&rft.title=Marine+Pollution+Bulletin&rft.issn=0025326X&rft_id=info:doi/10.1016%2Fj.marpolbul.2011.08.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2014-05-15 N1 - SubjectsTermNotLitGenreText - Pore water; Beaches; Sediment gravity flows; Marine pollution; Sediments; Freshwater environments; Sand; Rainfall; Rain; Sediment Transport; Water Pollution; Cores; Interstitial Water; Flow Control; Marine DO - http://dx.doi.org/10.1016/j.marpolbul.2011.08.049 ER - TY - JOUR T1 - 2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase AN - 904498597; 16000252 AB - Compared to normal differentiated cells, cancer cells have altered metabolic regulation to support biosynthesis and the expression of the M2 isozyme of pyruvate kinase (PKM2) plays an important role in this anabolic metabolism. While the M1 isoform is a highly active enzyme, the alternatively spliced M2 variant is considerably less active and expressed in tumors. While the exact mechanism by which decreased pyruvate kinase activity contributes to anabolic metabolism remains unclear, it is hypothesized that activation of PKM2 to levels seen with PKM1 may promote a metabolic program that is not conducive to cell proliferation. Here we report the third chemotype in a series of PKM2 activators based on the 2-oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamide scaffold. The synthesis, structure activity relationships, selectivity and notable physiochemical properties are described. JF - Bioorganic and Medicinal Chemistry Letters AU - Walsh, Martin J AU - Brimacombe, Kyle R AU - Veith, Henrike AU - Bougie, James M AU - Daniel, Thomas AU - Leister, William AU - Cantley, Lewis C AU - Israelsen, William J AU - Heiden, Matthew GVander AU - Shen, Min AU - Auld, Douglas S AU - Thomas, Craig J AU - Boxer, Matthew B AD - NIH Chemical Genomics Center, NIH Center for Translational Therapeutics, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA, boxerm@mail.nih.gov Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 6322 EP - 6327 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 21 IS - 21 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - Isoenzymes KW - Enzymes KW - Tumors KW - Cell proliferation KW - Tumor cells KW - Metabolism KW - Cancer KW - scaffolds KW - Pyruvate kinase KW - Alternative splicing KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904498597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=2-Oxo-N-aryl-1%2C2%2C3%2C4-tetrahydroquinoline-6-sulfonamides+as+activators+of+the+tumor+cell+specific+M2+isoform+of+pyruvate+kinase&rft.au=Walsh%2C+Martin+J%3BBrimacombe%2C+Kyle+R%3BVeith%2C+Henrike%3BBougie%2C+James+M%3BDaniel%2C+Thomas%3BLeister%2C+William%3BCantley%2C+Lewis+C%3BIsraelsen%2C+William+J%3BHeiden%2C+Matthew+GVander%3BShen%2C+Min%3BAuld%2C+Douglas+S%3BThomas%2C+Craig+J%3BBoxer%2C+Matthew+B&rft.aulast=Walsh&rft.aufirst=Martin&rft.date=2011-11-01&rft.volume=21&rft.issue=21&rft.spage=6322&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2011.08.114 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Isoenzymes; Enzymes; Tumors; Cell proliferation; Tumor cells; scaffolds; Cancer; Metabolism; Alternative splicing; Pyruvate kinase DO - http://dx.doi.org/10.1016/j.bmcl.2011.08.114 ER - TY - JOUR T1 - The effects of chronic treatment with mood stabilizers on the rat hippocampal post-synaptic density proteome. AN - 904222925; 21838781 AB - Bipolar disorder is a devastating illness that is marked by recurrent episodes of mania and depression. There is growing evidence that the disease is correlated with disruptions in synaptic plasticity cascades involved in cognition and mood regulation. Alleviating the symptoms of bipolar disorder involves chronic treatment with mood stabilizers like lithium or valproate. These two structurally dissimilar drugs are known to alter prominent signaling cascades in the hippocampus, but their effects on the post-synaptic density complex remain undefined. In this work, we utilized mass spectrometry for quantitative profiling of the rat hippocampal post-synaptic proteome to investigate the effects of chronic mood stabilizer treatment. Our data show that in response to chronic treatment of mood stabilizers there were not gross qualitative changes but rather subtle quantitative perturbations in post-synaptic density proteome linked to several key signaling pathways. Our data specifically support the changes in actin dynamics on valproate treatment. Using label-free quantification methods, we report that lithium and valproate significantly altered the abundance of 21 and 43 proteins, respectively. Seven proteins were affected similarly by both lithium and valproate: Ank3, glutamate receptor 3, dynein heavy chain 1, and four isoforms of the 14-3-3 family. Immunoblotting the same samples confirmed the changes in Ank3 and glutamate receptor 3 abundance. Our findings support the hypotheses that BPD is a synaptic disorder and that mood stabilizers modulate the protein signaling complex in the hippocampal post-synaptic density. Published 2011. This article is a US Government work and is in the public domain in the USA. JF - Journal of neurochemistry AU - Nanavati, Dhaval AU - Austin, Daniel R AU - Catapano, Lisa A AU - Luckenbaugh, David A AU - Dosemeci, Ayse AU - Manji, Husseini K AU - Chen, Guang AU - Markey, Sanford P AD - Laboratory of Neurotoxicology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-1262, USA. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 617 EP - 629 VL - 119 IS - 3 KW - Antipsychotic Agents KW - 0 KW - Proteome KW - Valproic Acid KW - 614OI1Z5WI KW - Lithium KW - 9FN79X2M3F KW - Index Medicus KW - Rats KW - Animals KW - Drug Administration Schedule KW - Rats, Inbred WKY KW - Gene Regulatory Networks -- drug effects KW - Treatment Outcome KW - Mood Disorders -- drug therapy KW - Gene Regulatory Networks -- physiology KW - Male KW - Proteome -- genetics KW - Post-Synaptic Density -- drug effects KW - Antipsychotic Agents -- administration & dosage KW - Proteome -- drug effects KW - Post-Synaptic Density -- genetics KW - Lithium -- administration & dosage KW - Hippocampus -- metabolism KW - Proteome -- metabolism KW - Valproic Acid -- administration & dosage KW - Post-Synaptic Density -- metabolism KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904222925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=The+effects+of+chronic+treatment+with+mood+stabilizers+on+the+rat+hippocampal+post-synaptic+density+proteome.&rft.au=Nanavati%2C+Dhaval%3BAustin%2C+Daniel+R%3BCatapano%2C+Lisa+A%3BLuckenbaugh%2C+David+A%3BDosemeci%2C+Ayse%3BManji%2C+Husseini+K%3BChen%2C+Guang%3BMarkey%2C+Sanford+P&rft.aulast=Nanavati&rft.aufirst=Dhaval&rft.date=2011-11-01&rft.volume=119&rft.issue=3&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=1471-4159&rft_id=info:doi/10.1111%2Fj.1471-4159.2011.07424.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-29 N1 - Date created - 2011-10-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Psychiatry. 2000 Mar;5(2):142-9 [10822341] J Neurochem. 2000 Oct;75(4):1729-34 [10987856] Eur J Pharmacol. 2000 Jul 21;400(2-3):221-4 [10988337] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4746-51 [11296301] J Biol Chem. 2001 Sep 28;276(39):36734-41 [11473107] Neuroreport. 2001 Oct 29;12(15):3257-62 [11711867] EMBO J. 2001 Dec 17;20(24):6969-78 [11742974] Neuron. 2002 Apr 25;34(3):411-23 [11988172] J Neurosci. 2002 Jun 1;22(11):4264-73 [12040031] Arch Gen Psychiatry. 2002 Jul;59(7):631-40 [12090816] Proteomics. 2003 Jan;3(1):19-28 [12548630] Mol Cell Neurosci. 2003 Jan;22(1):62-74 [12595239] Neuron. 2003 Apr 24;38(2):157-60 [12718851] Nat Neurosci. 2004 Apr;7(4):357-63 [15034585] Proc Natl Acad Sci U S A. 2004 May 4;101(18):7187-92 [15107502] Mol Psychiatry. 2004 Jun;9(6):609-20, 544 [14708030] J Proteome Res. 2004 Sep-Oct;3(5):1002-8 [15473689] Am J Psychiatry. 2004 Nov;161(11):1957-66 [15514393] J Cell Biol. 1980 Sep;86(3):831-45 [7410481] J Pharmacol Exp Ther. 1999 Oct;291(1):161-70 [10490900] Biol Psychiatry. 2004 Dec 15;56(12):943-50 [15601604] J Cell Biol. 2005 Jan 17;168(2):329-38 [15657400] Cell Res. 2005 Feb;15(2):83-91 [15740635] Neuropsychopharmacology. 2005 May;30(5):974-83 [15726117] J Biol Chem. 2005 May 27;280(21):20503-8 [15790563] Hum Mol Genet. 2005 Jul 1;14(13):1863-76 [15888475] Am J Psychiatry. 2005 Jul;162(7):1256-65 [15994707] Am J Hum Genet. 2005 Nov;77(5):685-93 [16252231] Nat Neurosci. 2005 Nov;8(11):1525-33 [16222232] Mol Cell Biol. 2005 Nov;25(22):9920-35 [16260607] J Biol Chem. 2005 Dec 23;280(51):41805-10 [16221686] Am J Hum Genet. 2005 Dec;77(6):918-36 [16380905] Hum Mol Genet. 2006 Mar 1;15(5):691-703 [16434483] NeuroRx. 2005 Oct;2(4):671-82 [16489374] Hum Mol Genet. 2006 Mar 15;15(6):965-77 [16467349] J Alzheimers Dis. 2005 Mar;8(4):377-86 [16556969] J Neurochem. 2006 Apr;97 Suppl 1:16-23 [16635246] Mol Cell Proteomics. 2006 May;5(5):914-22 [16452087] Bipolar Disord. 2006 Jun;8(3):255-64 [16696827] Biol Psychiatry. 2006 Jun 1;59(11):1006-20 [16487491] Amino Acids. 2006 Jun;30(4):477-93 [16583313] Lancet Neurol. 2006 Nov;5(11):911-6 [17052657] Mol Psychiatry. 2007 Jan;12(1):74-86 [17043677] Psychiatry Clin Neurosci. 2007 Feb;61(1):3-19 [17239033] Lancet Neurol. 2007 Apr;6(4):322-8 [17362836] Neuroscience. 2007 Apr 14;145(4):1233-48 [17303344] Nature. 2007 Jun 7;447(7145):661-78 [17554300] Annu Rev Biochem. 2007;76:823-47 [17243894] EMBO J. 2007 Jun 20;26(12):2991-3002 [17541406] J Biol Chem. 2007 Jul 6;282(27):19884-93 [17439943] Genes Dev. 2007 Sep 15;21(18):2347-57 [17875668] Mol Cell Proteomics. 2007 Oct;6(10):1749-60 [17623647] J Biol Chem. 2007 Oct 19;282(42):30523-34 [17761673] Psychopharmacology (Berl). 2007 Dec;195(3):357-67 [17705060] Neuropsychopharmacology. 2008 Jan;33(2):361-7 [17406649] Arch Neurol. 2008 Jan;65(1):45-53 [17998437] Invest Ophthalmol Vis Sci. 2008 Feb;49(2):788-99 [18235029] Nat Neurosci. 2008 Jul;11(7):799-806 [18536710] J Proteomics. 2008 Aug 21;71(3):346-56 [18639657] J Neural Transm (Vienna). 2008 Sep;115(9):1355-65 [18665322] Hum Mol Genet. 2008 Oct 15;17(20):3212-22 [18658164] Mol Cell Proteomics. 2008 Nov;7(11):2123-37 [18614564] Neoplasia. 2009 Jan;11(1):77-86, 4p following 86 [19107234] J Neural Transm (Vienna). 2009 Mar;116(3):275-89 [19034380] Ann Med. 2009;41(3):177-85 [18932104] Mol Psychiatry. 2009 May;14(5):487-91 [19088739] Am J Pathol. 2009 Jul;175(1):17-24 [19497998] Neuron. 2009 Sep 10;63(5):628-42 [19755106] Am J Med Genet B Neuropsychiatr Genet. 2009 Oct 5;150B(7):977-83 [19160447] Dialogues Clin Neurosci. 2009;11(3):333-48 [19877500] J Neurosci. 2009 Nov 4;29(44):14039-49 [19890013] Mol Cell Neurosci. 2009 Dec;42(4):466-83 [19796685] Mol Cell Neurosci. 2009 Dec;42(4):448-57 [19796686] Neuron. 2010 Feb 25;65(4):445-59 [20188650] Proteomics. 2010 Aug;10(16):3035-9 [20564260] J Neurophysiol. 2010 Apr;103(4):1758-70 [20107120] Electrophoresis. 1999 Dec;20(18):3551-67 [10612281] J Biol Chem. 2000 Feb 4;275(5):3247-55 [10652311] Curr Opin Cell Biol. 2000 Feb;12(1):97-103 [10679358] J Neurosci. 2000 May 1;20(9):3076-84 [10777771] Hum Mol Genet. 2000 May 22;9(9):1259-71 [10814708] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1471-4159.2011.07424.x ER - TY - JOUR T1 - super(68)Ga-DOTA-Affibody molecule for in vivo assessment of HER2/neu expression with PET AN - 902348494; 15845818 AB - Purpose: Overexpression of HER2/neu in breast cancer is correlated with a poor prognosis. It may vary between primary tumors and metastatic lesions and change during the treatment. Therefore, there is a need for a new means to assess HER2/neu expression in vivo. In this work, we used super(68)Ga-labeled DOTA-Z sub(HER2:2891)-Affibody to monitor HER2/neu expression in a panel of breast cancer xenografts. Methods: DOTA-Z sub(HER2:2891)-Affibody molecules were labeled with super(68)Ga. In vitro binding was characterized by a receptor saturation assay. Biodistribution and PET imaging studies were conducted in athymic nude mice bearing subcutaneous human breast cancer tumors with three different levels of HER2/neu expression. Nonspecific uptake was analyzed using non-HER2-specific Affibody molecules. Signal detected by PET was compared with ex vivo assessment of the tracer uptake and HER2/neu expression. Results: The super(68)Ga-DOTA-Z sub(HER2:2891)-Affibody probe showed high binding affinity to MDA-MB-361 cells (K sub(D)=1.4+/-0.19 nM). In vivo biodistribution and PET imaging studies demonstrated high radioactivity uptake in HER2/neu-positive tumors. Tracer was eliminated quickly from the blood and normal tissues, resulting in high tumor-to-blood ratios. The highest concentration of radioactivity in normal tissue was seen in the kidneys (227+/-14%ID/g). High-contrast PET images of HER2/neu-overexpressing tumors were recorded as soon as 1 h after tracer injection. A good correlation was observed between PET imaging, biodistribution estimates of tumor tracer concentration, and the receptor expression. Conclusion: These results suggest that PET imaging using super(68)Ga-DOTA-Z sub(HER2:2891)-Affibody is sensitive enough to detect different levels of HER2/neu expression in vivo. JF - European Journal of Nuclear Medicine and Molecular Imaging AU - Kramer-Marek, Gabriela AU - Shenoy, Nalini AU - Seidel, Jurgen AU - Griffiths, Gary L AU - Choyke, Peter AU - Capala, Jacek AD - National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA, capalaj@mail.nih.gov capalaj@mail.nih.gov capalaj@mail.nih.gov capalaj@mail.nih.gov capalaj@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1967 EP - 1976 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 38 IS - 11 SN - 1619-7070, 1619-7070 KW - Biotechnology and Bioengineering Abstracts KW - ErbB-2 protein KW - Probes KW - Prognosis KW - Tumors KW - Metastases KW - Tracers KW - Blood KW - Kidney KW - Breast cancer KW - Nuclear medicine KW - Radioactivity KW - Xenografts KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902348494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.atitle=super%2868%29Ga-DOTA-Affibody+molecule+for+in+vivo+assessment+of+HER2%2Fneu+expression+with+PET&rft.au=Kramer-Marek%2C+Gabriela%3BShenoy%2C+Nalini%3BSeidel%2C+Jurgen%3BGriffiths%2C+Gary+L%3BChoyke%2C+Peter%3BCapala%2C+Jacek&rft.aulast=Kramer-Marek&rft.aufirst=Gabriela&rft.date=2011-11-01&rft.volume=38&rft.issue=11&rft.spage=1967&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.issn=16197070&rft_id=info:doi/10.1007%2Fs00259-011-1810-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Metastases; Blood; Tracers; ErbB-2 protein; Prognosis; Probes; Kidney; Nuclear medicine; Breast cancer; Xenografts; Radioactivity; Tumors DO - http://dx.doi.org/10.1007/s00259-011-1810-4 ER - TY - JOUR T1 - Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer. AN - 902329191; 22027685 AB - Smoking is the leading cause of preventable cancer deaths in the United States. Nicotine replacement therapies (NRT) have been developed to aid in smoking cessation, which decreases lung cancer incidence. However, the safety of NRT is controversial because numerous preclinical studies have shown that nicotine enhances tumor cell growth in vitro and in vivo. We modeled NRT in mice to determine the effects of physiologic levels of nicotine on lung tumor formation, tumor growth, or metastasis. Nicotine administered in drinking water did not enhance lung tumorigenesis after treatment with the tobacco carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Tumors that develop in this model have mutations in K-ras, which is commonly observed in smoking-related, human lung adenocarcinomas. In a transgenic model of mutant K-ras-driven lung cancer, nicotine did not increase tumor number or size and did not affect overall survival. Likewise, in a syngeneic model using lung cancer cell lines derived from NNK-treated mice, oral nicotine did not enhance tumor growth or metastasis. These data show that nicotine does not enhance lung tumorigenesis when given to achieve levels comparable with those of NRT, suggesting that nicotine has a dose threshold, below which it has no appreciable effect. These studies are consistent with epidemiologic data showing that NRT does not enhance lung cancer risk in former smokers. JF - Cancer prevention research (Philadelphia, Pa.) AU - Maier, Colleen R AU - Hollander, M Christine AU - Hobbs, Evthokia A AU - Dogan, Irem AU - Linnoila, R Ilona AU - Dennis, Phillip A AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 1743 EP - 1751 VL - 4 IS - 11 KW - Carcinogens KW - 0 KW - Drinking Water KW - Nitrosamines KW - Nicotine KW - 6M3C89ZY6R KW - 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone KW - 7S395EDO61 KW - Kras2 protein, mouse KW - EC 3.6.5.2 KW - Proto-Oncogene Proteins p21(ras) KW - Index Medicus KW - Nitrosamines -- toxicity KW - Mice, Inbred A KW - Animals KW - Cells, Cultured KW - Humans KW - Mice, Inbred C57BL KW - Carcinogens -- toxicity KW - Mice KW - Male KW - Female KW - Lung Neoplasms -- etiology KW - Cell Transformation, Neoplastic -- pathology KW - Adenocarcinoma -- etiology KW - Lung Neoplasms -- drug therapy KW - Nicotine -- administration & dosage KW - Mutation -- genetics KW - Disease Models, Animal KW - Adenocarcinoma -- drug therapy KW - Proto-Oncogene Proteins p21(ras) -- genetics KW - Lung Neoplasms -- pathology KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902329191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.atitle=Nicotine+does+not+enhance+tumorigenesis+in+mutant+K-ras-driven+mouse+models+of+lung+cancer.&rft.au=Maier%2C+Colleen+R%3BHollander%2C+M+Christine%3BHobbs%2C+Evthokia+A%3BDogan%2C+Irem%3BLinnoila%2C+R+Ilona%3BDennis%2C+Phillip+A&rft.aulast=Maier&rft.aufirst=Colleen&rft.date=2011-11-01&rft.volume=4&rft.issue=11&rft.spage=1743&rft.isbn=&rft.btitle=&rft.title=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.issn=1940-6215&rft_id=info:doi/10.1158%2F1940-6207.CAPR-11-0365 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-12 N1 - Date created - 2011-11-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 2005 Jan 17;92(1):131-9 [15597105] Oncogene. 2011 Apr 14;30(15):1812-21 [21242979] Int J Epidemiol. 2000 Dec;29(6):963-8 [11101535] Nature. 2001 Apr 26;410(6832):1111-6 [11323676] Cancer Res. 2001 May 15;61(10):3986-97 [11358816] Nat Med. 2001 Jul;7(7):833-9 [11433349] Genes Dev. 2001 Dec 15;15(24):3243-8 [11751630] J Clin Invest. 2003 Jan;111(1):81-90 [12511591] IARC Sci Publ. 1978;(19):395-413 [680735] Cancer Res. 1989 Jul 15;49(14):3770-5 [2736518] Cancer Res. 1991 Oct 15;51(20):5557-64 [1913675] Cancer Res. 1992 Jun 1;52(11):3164-73 [1591728] Int J Cancer. 1993 Jan 21;53(2):250-6 [8425762] Clin Pharmacol Ther. 1993 Jul;54(1):98-106 [8330471] JAMA. 1995 Nov 1;274(17):1353-8 [7563559] Psychopharmacology (Berl). 1996 Apr;124(4):332-9 [8739548] Anticancer Res. 1996 Nov-Dec;16(6B):3615-9 [9042230] Carcinogenesis. 1998 Aug;19(8):1503-8 [9744549] Carcinogenesis. 1999 Aug;20(8):1577-82 [10426810] Cancer Prev Res (Phila). 2011 Nov;4(11):1752-60 [22027684] J Biol Chem. 2005 Feb 25;280(8):6369-79 [15574422] Int J Oncol. 2006 Feb;28(2):337-44 [16391787] DNA Cell Biol. 2006 May;25(5):312-22 [16716121] Clin Cancer Res. 2007 Apr 1;13(7):2281-9 [17404113] Nat Protoc. 2006;1(3):1112-6 [17406391] Mutat Res. 2008 Sep-Oct;659(3):221-31 [18495523] Int J Cancer. 2009 Jan 1;124(1):36-45 [18844224] Annu Rev Pharmacol Toxicol. 2009;49:57-71 [18834313] PLoS One. 2009;4(3):e5061 [19330036] Cell. 2009 May 29;137(5):835-48 [19490893] Nicotine Tob Res. 2009 Sep;11(9):1076-82 [19571249] PLoS One. 2009;4(10):e7524 [19841737] J Cell Biochem. 2010 Jan 1;109(1):152-61 [19911375] Cancer. 2010 Feb 1;116(3):544-73 [19998273] Am J Rhinol Allergy. 2010 Mar-Apr;24(2):e73-7 [20338106] Toxicol Sci. 2010 May;115(1):118-30 [20106947] Cancer Prev Res (Phila). 2010 Sep;3(9):1066-76 [20810672] J Pharmacol Exp Ther. 2010 Dec;335(3):553-61 [20843956] Comment In: Cancer Prev Res (Phila). 2011 Nov;4(11):1719-23 [22052338] Cancer Prev Res (Phila). 2011 Nov;4(11):1724-7 [22052339] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1940-6207.CAPR-11-0365 ER - TY - JOUR T1 - A phase I study of PF-04929113 (SNX-5422), an orally bioavailable heat shock protein 90 inhibitor, in patients with refractory solid tumor malignancies and lymphomas. AN - 902086157; 21908572 AB - To determine the maximum tolerated dose (MTD), toxicities, and pharmacokinetic/pharmacodynamic profile of the Hsp90 inhibitor PF-04929113 (SNX-5422) in patients with advanced solid tumors and lymphomas. This was a single-institution, phase I, dose-escalation study of PF-04929113 administered twice weekly. Endpoints included determination of dose-limiting toxicities (DLT), MTD, the safety profile of PF-04929113, pharmacodynamic assessment of PF-04929113 on Hsp70 induction, pharmacokinetic analysis of PF-04928473 (SNX-2112) and its prodrug PF-04929113, and assessment of response. Thirty-three patients with advanced malignancies were treated. Dose escalation was continued up to 177 mg/m(2) administered orally twice a week. One DLT (nonseptic arthritis) was noted. No grade 4 drug-related adverse events were seen; grade 3 adverse events included diarrhea (9%), nonseptic arthritis (3%), aspartate aminotransferase elevation (3%), and thrombocytopenia (3%). No objective responses were seen in 32 evaluable patients. Fifteen patients (47%) had stable disease; 17 patients (53%) had progressive disease. Pharmacokinetic data revealed rapid absorption, hepatic, and extrahepatic clearance, extensive tissue binding, and almost linear pharmacokinetics of the active drug PF-04928473. Pharmacodynamic studies confirmed inhibition of Hsp90 and a linear correlation between pharmacokinetic parameters and Hsp70 induction. PF-04929113 administered orally twice a week is well tolerated and inhibits its intended target Hsp90. No objective responses were seen, but long-lasting stabilizations were obtained. Although no clinically significant drug-related ocular toxicity was seen in this study, the development of PF-04929113 has been discontinued because of ocular toxicity seen in animal models and in a separate phase I study. ©2011 AACR JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Rajan, Arun AU - Kelly, Ronan J AU - Trepel, Jane B AU - Kim, Yeong Sang AU - Alarcon, Sylvia V AU - Kummar, Shivaani AU - Gutierrez, Martin AU - Crandon, Sonja AU - Zein, Wadih M AU - Jain, Lokesh AU - Mannargudi, Baskar AU - Figg, William D AU - Houk, Brett E AU - Shnaidman, Michael AU - Brega, Nicoletta AU - Giaccone, Giuseppe AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 6831 EP - 6839 VL - 17 IS - 21 SN - 1078-0432, 1078-0432 KW - Benzamides KW - 0 KW - HSP90 Heat-Shock Proteins KW - Indazoles KW - PF 04929113 KW - Index Medicus KW - Drug Administration Schedule KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Neoplasms -- drug therapy KW - Benzamides -- adverse effects KW - Benzamides -- pharmacokinetics KW - Neoplasms -- blood KW - HSP90 Heat-Shock Proteins -- blood KW - Indazoles -- administration & dosage KW - Indazoles -- adverse effects KW - Indazoles -- pharmacokinetics KW - Lymphoma -- blood KW - Lymphoma -- drug therapy KW - HSP90 Heat-Shock Proteins -- antagonists & inhibitors KW - Benzamides -- administration & dosage KW - Lymphoma -- metabolism KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902086157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=A+phase+I+study+of+PF-04929113+%28SNX-5422%29%2C+an+orally+bioavailable+heat+shock+protein+90+inhibitor%2C+in+patients+with+refractory+solid+tumor+malignancies+and+lymphomas.&rft.au=Rajan%2C+Arun%3BKelly%2C+Ronan+J%3BTrepel%2C+Jane+B%3BKim%2C+Yeong+Sang%3BAlarcon%2C+Sylvia+V%3BKummar%2C+Shivaani%3BGutierrez%2C+Martin%3BCrandon%2C+Sonja%3BZein%2C+Wadih+M%3BJain%2C+Lokesh%3BMannargudi%2C+Baskar%3BFigg%2C+William+D%3BHouk%2C+Brett+E%3BShnaidman%2C+Michael%3BBrega%2C+Nicoletta%3BGiaccone%2C+Giuseppe&rft.aulast=Rajan&rft.aufirst=Arun&rft.date=2011-11-01&rft.volume=17&rft.issue=21&rft.spage=6831&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-11-0821 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-20 N1 - Date created - 2011-11-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 1999 Apr;17(4):1244 [10561185] J Thorac Oncol. 2008 Jun;3(6 Suppl 2):S152-9 [18520302] Exp Biol Med (Maywood). 2003 Feb;228(2):111-33 [12563018] Nature. 2003 Sep 25;425(6956):407-10 [14508491] J Clin Oncol. 2005 Mar 20;23(9):1885-93 [15774780] J Biol Chem. 2008 Jul 4;283(27):18473-7 [18442971] Cancer Res. 2008 Jul 15;68(14):5827-38 [18632637] Blood. 2009 Jan 22;113(4):846-55 [18948577] Mol Cell. 2009 Oct 9;36(1):15-27 [19818706] Mol Cell. 2009 Oct 23;36(2):176-7 [19854128] Oncol Res. 2009;18(5-6):229-42 [20225761] Nat Rev Mol Cell Biol. 2010 Jul;11(7):515-28 [20531426] Exp Eye Res. 2010 Aug;91(2):211-9 [20493187] Nat Rev Cancer. 2010 Aug;10(8):537-49 [20651736] J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Nov 15;878(30):3187-92 [20951100] J Clin Oncol. 2010 Nov 20;28(33):4953-60 [20940188] Br J Haematol. 2011 Feb;152(4):367-79 [21219297] J Clin Oncol. 2005 Jun 20;23(18):4152-61 [15961763] Clin Cancer Res. 2007 Mar 15;13(6):1625-9 [17363512] Clin Cancer Res. 2007 Mar 15;13(6):1769-74 [17363531] Clin Cancer Res. 2007 Mar 15;13(6):1775-82 [17363532] Br J Cancer. 2007 Sep 17;97(6):741-4 [17712310] Cell. 2007 Sep 21;130(6):1005-18 [17889646] Clin Cancer Res. 2008 Jan 1;14(1):240-8 [18172276] J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-11-0821 ER - TY - JOUR T1 - AMPA induced Ca2+ influx in motor neurons occurs through voltage gated Ca2+ channel and Ca2+ permeable AMPA receptor. AN - 901644317; 21777635 AB - The rise in intracellular Ca(2+) mediated by AMPA subtype of glutamate receptors has been implicated in the pathogenesis of motor neuron disease, but the exact route of Ca(2+) entry into motor neurons is not clearly known. In the present study, we examined the role of voltage gated calcium channels (VGCCs) in AMPA induced Ca(2+) influx and subsequent intracellular signaling events responsible for motor neuron degeneration. AMPA stimulation caused sodium influx in spinal neurons that would depolarize the plasma membrane. The AMPA induced [Ca(2+)](i) rise in motor neurons as well as other spinal neurons was drastically reduced when extracellular sodium was replaced with NMDG, suggesting the involvement of voltage gated calcium channels. AMPA mediated rise in [Ca(2+)](i) was significantly inhibited by L-type VGCC blocker nifedipine, whereas ω-agatoxin-IVA and ω-conotoxin-GVIA, specific blockers of P/Q type and N-type VGCC were not effective. 1-Napthyl-acetyl spermine (NAS), an antagonist of Ca(2+) permeable AMPA receptors partially inhibited the AMPA induced [Ca(2+)](i) rise but selectively in motor neurons. Measurement of AMPA induced currents in whole cell voltage clamp mode suggests that a moderate amount of Ca(2+) influx occurs through Ca(2+) permeable AMPA receptors in a subpopulation of motor neurons. The AMPA induced mitochondrial calcium loading [Ca(2+)](m), mitochondrial depolarization and neurotoxicity were also significantly reduced in presence of nifedipine. Activation of VGCCs by depolarizing concentration of KCl (30mM) in extracellular medium increased the [Ca(2+)](i) but no change was observed in mitochondrial Ca(2+) and membrane potential. Our results demonstrate that a subpopulation of motor neurons express Ca(2+) permeable AMPA receptors, however the larger part of Ca(2+) influx occurs through L-type VGCCs subsequent to AMPA receptor activation and consequent mitochondrial dysfunction is the trigger for motor neuron degeneration. Nifedipine is an effective protective agent against AMPA induced mitochondrial stress and degeneration of motor neurons. Copyright © 2011 Elsevier B.V. All rights reserved. JF - Neurochemistry international AU - Joshi, Dinesh C AU - Singh, Mahendra AU - Krishnamurthy, Karthik AU - Joshi, Preeti G AU - Joshi, Nanda B AD - Department of Biophysics, National Institute of Mental Health and Neuro Sciences, Bangalore 560 029, India. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 913 EP - 921 VL - 59 IS - 6 KW - Calcium Channels KW - 0 KW - Calcium Channels, L-Type KW - Receptors, AMPA KW - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid KW - 77521-29-0 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Calcium Channels, L-Type -- physiology KW - Primary Cell Culture KW - Motor Neurons -- metabolism KW - Calcium Channels -- physiology KW - Cell Membrane Permeability -- physiology KW - Spinal Cord -- metabolism KW - Receptors, AMPA -- physiology KW - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid -- pharmacology KW - Receptors, AMPA -- agonists KW - Calcium Signaling -- drug effects KW - Calcium Signaling -- physiology KW - Cell Membrane Permeability -- drug effects KW - Spinal Cord -- drug effects KW - Motor Neurons -- drug effects KW - Spinal Cord -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/901644317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemistry+international&rft.atitle=AMPA+induced+Ca2%2B+influx+in+motor+neurons+occurs+through+voltage+gated+Ca2%2B+channel+and+Ca2%2B+permeable+AMPA+receptor.&rft.au=Joshi%2C+Dinesh+C%3BSingh%2C+Mahendra%3BKrishnamurthy%2C+Karthik%3BJoshi%2C+Preeti+G%3BJoshi%2C+Nanda+B&rft.aulast=Joshi&rft.aufirst=Dinesh&rft.date=2011-11-01&rft.volume=59&rft.issue=6&rft.spage=913&rft.isbn=&rft.btitle=&rft.title=Neurochemistry+international&rft.issn=1872-9754&rft_id=info:doi/10.1016%2Fj.neuint.2011.06.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2013-01-29 N1 - Date created - 2011-11-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuint.2011.06.023 ER - TY - JOUR T1 - [Molecular diagnosis of HPV infections]. TT - Molekulare Diagnostik der HPV-Infektion. AN - 901308178; 21845360 AB - Carcinogenic human papillomaviruses (HPV) cause the majority of cervical cancers and other anogenital cancers. Large randomized trials have shown that HPV testing can be efficiently used for primary cervical cancer screening. Other applications include the triage of abnormal cytology results and the follow-up of women after treatment. Many assays have been developed to measure DNA, RNA and proteins of HPV and the various tests can have very different applications. It is important to rigorously validate HPV assays before they are implemented in screening or clinical care. JF - Der Pathologe AU - Wentzensen, N AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852-7234, Maryland, USA. wentzenn@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 461 EP - 466 VL - 32 IS - 6 KW - Index Medicus KW - Cervix Uteri -- pathology KW - Genome, Viral -- genetics KW - Cell Transformation, Neoplastic -- pathology KW - Humans KW - Predictive Value of Tests KW - Uterine Cervical Dysplasia -- virology KW - Uterine Cervical Dysplasia -- genetics KW - Precancerous Conditions -- pathology KW - Precancerous Conditions -- virology KW - Uterine Cervical Dysplasia -- pathology KW - Mass Screening KW - Precancerous Conditions -- genetics KW - Vaginal Smears KW - Cervix Uteri -- virology KW - Precancerous Conditions -- diagnosis KW - Uterine Cervical Dysplasia -- diagnosis KW - Cell Transformation, Neoplastic -- genetics KW - Female KW - Papillomavirus Infections -- pathology KW - Papillomavirus Infections -- diagnosis KW - Uterine Cervical Neoplasms -- diagnosis KW - Papillomavirus Infections -- virology KW - Uterine Cervical Neoplasms -- genetics KW - Papillomavirus Infections -- genetics KW - Human papillomavirus 16 -- genetics KW - Molecular Diagnostic Techniques -- methods KW - Uterine Cervical Neoplasms -- pathology KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/901308178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Der+Pathologe&rft.atitle=%5BMolecular+diagnosis+of+HPV+infections%5D.&rft.au=Wentzensen%2C+N&rft.aulast=Wentzensen&rft.aufirst=N&rft.date=2011-11-01&rft.volume=32&rft.issue=6&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Der+Pathologe&rft.issn=1432-1963&rft_id=info:doi/10.1007%2Fs00292-011-1475-6 LA - ger DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-17 N1 - Date created - 2011-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2002 Dec 1;62(23):7075-82 [12460929] J Natl Cancer Inst. 2011 Mar 2;103(5):368-83 [21282563] J Pathol. 1999 Sep;189(1):12-9 [10451482] J Natl Cancer Inst. 2005 Jan 19;97(2):147-50 [15657345] J Clin Virol. 2005 Mar;32 Suppl 1:S43-51 [15753011] Lancet Oncol. 2005 Apr;6(4):204 [15830458] Vaccine. 2006 Aug 31;24 Suppl 3:S3/11-25 [16949997] Dis Markers. 2007;23(4):273-81 [17627062] Dis Markers. 2007;23(4):297-313 [17627064] Dis Markers. 2007;23(4):315-30 [17627065] Lancet. 2007 Sep 8;370(9590):890-907 [17826171] Int J Cancer. 2007 Dec 15;121(12):2787-93 [17722112] Lancet Oncol. 2008 May;9(5):425-34 [18407790] Lancet Oncol. 2008 May;9(5):404-6 [18452848] J Clin Microbiol. 2008 Aug;46(8):2595-604 [18579716] Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2536-45 [18842994] Int J Cancer. 2009 Feb 1;124(3):516-20 [18973271] J Natl Cancer Inst. 2009 Apr 1;101(7):475-87 [19318628] Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1341-9 [19423515] J Med Virol. 2010 Apr;82(4):605-15 [20166179] Cancer Res. 2010 Apr 15;70(8):3159-69 [20354192] Am J Clin Pathol. 2010 Aug;134(2):193-9 [20660320] Am J Surg Pathol. 2010 Aug;34(8):1077-87 [20661011] Int J Cancer. 2011 Feb 15;128(4):927-35 [20473886] Gynecol Oncol. 2011 Mar;120(3):430-8 [21130490] Am J Clin Pathol. 2011 Mar;135(3):468-75 [21350104] Comment In: Pathologe. 2011 Nov;32(6):449-50 [22038131] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00292-011-1475-6 ER - TY - JOUR T1 - Nuclear receptor CAR (NR1I3) is essential for DDC-induced liver injury and oval cell proliferation in mouse liver. AN - 901308056; 21826054 AB - The liver is endowed with the ability to regenerate hepatocytes in response to injury. When this regeneration ability is impaired during liver injury, oval cells, which are considered to be postnatal hepatic progenitors, proliferate and differentiate into hepatocytes. Here we have demonstrated that 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) activates the nuclear receptor constitutive active/androstane receptor (CAR), resulting in proliferation of oval cells in mouse liver. Activation of CAR by DDC was shown by hepatic nuclear CAR accumulation and cytochrome P450 (CYP)2B10 mRNA induction after feeding a 0.1% DDC-containing diet to Car(+/+) mice. After being fed the DDC diet, Car(+/+), but not Car(-/-) mice, developed severe liver injury and an A6 antibody-stained ductular reaction in an area around the portal tract. Oval cell proliferation was confirmed by laser capture microdissection and real-time PCR; mRNAs for the two oval cell markers epithelial cell adhesion molecule and TROP2 were specifically induced in the periportal region of DDC diet-fed Car(+/+), but not Car(-/-) mice. Although rates of both hepatocyte growth and death were initially enhanced only in DDC diet-fed Car(+/+) mice, growth was attenuated when oval cells proliferated, whereas death continued unabated. DDC-induced liver injury, which differs from other CAR activators such as phenobarbital, occurred in the periportal region where cells developed hypertrophy, accumulated porphyrin crystals and inflammation developed, all in association with the proliferation of oval cells. Thus, CAR provides an excellent experimental model for further investigations into its roles in liver regeneration, as well as the development of diseases such as hepatocellular carcinoma. JF - Laboratory investigation; a journal of technical methods and pathology AU - Yamazaki, Yuichi AU - Moore, Rick AU - Negishi, Masahiko AD - Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 1624 EP - 1633 VL - 91 IS - 11 KW - 3,5-diethoxycarbonyl-1,4-dihydrocollidine KW - 0 KW - Antigens, Neoplasm KW - Cell Adhesion Molecules KW - Pyridines KW - Receptors, Cytoplasmic and Nuclear KW - TROP2 protein, mouse KW - constitutive androstane receptor KW - Index Medicus KW - Real-Time Polymerase Chain Reaction KW - Animals KW - Blotting, Western KW - Apoptosis -- physiology KW - Cell Adhesion Molecules -- metabolism KW - Antigens, Neoplasm -- metabolism KW - Mice KW - Laser Capture Microdissection KW - Cell Proliferation KW - Mice, Knockout KW - Liver -- cytology KW - Cell Differentiation -- physiology KW - Liver -- injuries KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - Stem Cells -- physiology KW - Liver Regeneration -- physiology KW - Pyridines -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/901308056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.atitle=Nuclear+receptor+CAR+%28NR1I3%29+is+essential+for+DDC-induced+liver+injury+and+oval+cell+proliferation+in+mouse+liver.&rft.au=Yamazaki%2C+Yuichi%3BMoore%2C+Rick%3BNegishi%2C+Masahiko&rft.aulast=Yamazaki&rft.aufirst=Yuichi&rft.date=2011-11-01&rft.volume=91&rft.issue=11&rft.spage=1624&rft.isbn=&rft.btitle=&rft.title=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.issn=1530-0307&rft_id=info:doi/10.1038%2Flabinvest.2011.115 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-19 N1 - Date created - 2011-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2004 Oct 15;64(20):7197-200 [15492232] Mol Cell Biol. 2004 Sep;24(18):7931-40 [15340055] Biochem J. 1992 Aug 1;285 ( Pt 3):979-83 [1497633] Toxicol Sci. 1998 Jul;44(1):46-51 [9720140] Lab Invest. 1999 Feb;79(2):103-9 [10068199] Mol Cell Biol. 1999 Sep;19(9):6318-22 [10454578] Biochem J. 2005 Jun 1;388(Pt 2):623-30 [15610065] Hepatology. 2006 Feb;43(2 Suppl 1):S45-53 [16447274] J Pharmacol Exp Ther. 2007 Jan;320(1):307-13 [17050775] Hepatology. 2007 Jan;45(1):31-41 [17187411] Gut. 2007 Apr;56(4):565-74 [16950832] Drug Metab Pharmacokinet. 2008;23(1):8-13 [18305370] Mol Pharmacol. 2008 Apr;73(4):1113-21 [18202305] Biochim Biophys Acta. 2008 Apr;1782(4):239-49 [18222182] J Clin Invest. 2008 May;118(5):1911-23 [18382767] Hepatology. 2009 Jan;49(1):318-29 [19111019] Development. 2009 Jun;136(11):1951-60 [19429791] Gastroenterology. 2009 Aug;137(2):466-81 [19470389] Biochem Biophys Res Commun. 2000 Oct 14;277(1):1-6 [11027630] Mol Pharmacol. 2002 Jan;61(1):1-6 [11752199] Mech Dev. 2003 Jan;120(1):117-30 [12490302] Proc Natl Acad Sci U S A. 2003 Sep 30;100 Suppl 1:11881-8 [12902545] Int J Exp Pathol. 1991 Dec;72(6):695-703 [1768614] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/labinvest.2011.115 ER - TY - JOUR T1 - IL-5 receptor α levels in patients with marked eosinophilia or mastocytosis. AN - 901306950; 21762978 AB - IL-5 plays a central role in the development and maintenance of eosinophilia (EO) and eosinophil activation in a wide variety of eosinophilic disorders. Although IL-5, IL-3, and GM-CSF can modulate the expression of IL-5 receptor α (IL-5Rα) on eosinophils in vitro, little is known about soluble and surface IL-5Rα levels in vivo. To assess soluble and surface IL-5Rα levels in patients with EO and/or mastocytosis. Surface IL-5Rα expression was assessed by flow cytometry in blood and/or bone marrow from subjects with EO (n = 39) and systemic mastocytosis (n = 8) and from normal volunteers (n = 28). Soluble IL-5Rα (sIL-5Rα) level was measured in a cohort of 177 untreated subjects and correlated with EO, eosinophil activation, and serum tryptase and cytokine levels. IL-5Rα expression on eosinophils inversely correlated with EO (r = -0.48; P < .0001), whereas serum levels of sIL-5Rα increased with the eosinophil count (r = 0.56; P < .0001) and serum IL-5 (r = 0.40; P < .0001) and IL-13 (r = 0.29; P = .004) levels. Of interest, sIL-5Rα level was significantly elevated in patients with systemic mastocytosis without EO. Although sIL-5Rα levels correlated with serum tryptase levels in these patients, eosinophil activation, assessed by CD69 expression on eosinophils and serum eosinophil-derived neurotoxin levels, was increased compared with that in normal subjects. These data are consistent with an in vivo IL-5Rα regulatory pathway in human eosinophils similar to that described in vitro and involving a balance between soluble and surface receptor levels. This may have implications with respect to the use of novel therapeutic agents targeting IL-5 and its receptor in patients with EO and/or mastocytosis. Published by Mosby, Inc. JF - The Journal of allergy and clinical immunology AU - Wilson, Todd M AU - Maric, Irina AU - Shukla, Juhi AU - Brown, Margaret AU - Santos, Carlo AU - Simakova, Olga AU - Khoury, Paneez AU - Fay, Michael P AU - Kozhich, Alexander AU - Kolbeck, Roland AU - Metcalfe, Dean D AU - Klion, Amy D AD - Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 1086 EP - 92.e1-3 VL - 128 IS - 5 KW - Cytokines KW - 0 KW - IL5RA protein, human KW - Interleukin-5 Receptor alpha Subunit KW - Eosinophil-Derived Neurotoxin KW - EC 3.1.- KW - Tryptases KW - EC 3.4.21.59 KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Eosinophil-Derived Neurotoxin -- immunology KW - Humans KW - Cytokines -- biosynthesis KW - Cytokines -- immunology KW - Tryptases -- blood KW - Aged KW - Cell Separation KW - Eosinophil-Derived Neurotoxin -- biosynthesis KW - Eosinophils -- immunology KW - Cytokines -- analysis KW - Eosinophil-Derived Neurotoxin -- analysis KW - Adult KW - Eosinophils -- metabolism KW - Enzyme-Linked Immunosorbent Assay KW - Middle Aged KW - Flow Cytometry KW - Male KW - Female KW - Mastocytosis, Systemic -- immunology KW - Interleukin-5 Receptor alpha Subunit -- immunology KW - Eosinophilia -- metabolism KW - Interleukin-5 Receptor alpha Subunit -- biosynthesis KW - Mastocytosis, Systemic -- metabolism KW - Eosinophilia -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/901306950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=IL-5+receptor+%CE%B1+levels+in+patients+with+marked+eosinophilia+or+mastocytosis.&rft.au=Wilson%2C+Todd+M%3BMaric%2C+Irina%3BShukla%2C+Juhi%3BBrown%2C+Margaret%3BSantos%2C+Carlo%3BSimakova%2C+Olga%3BKhoury%2C+Paneez%3BFay%2C+Michael+P%3BKozhich%2C+Alexander%3BKolbeck%2C+Roland%3BMetcalfe%2C+Dean+D%3BKlion%2C+Amy+D&rft.aulast=Wilson&rft.aufirst=Todd&rft.date=2011-11-01&rft.volume=128&rft.issue=5&rft.spage=1086&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=1097-6825&rft_id=info:doi/10.1016%2Fj.jaci.2011.05.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-12 N1 - Date created - 2011-10-31 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Blood. 2000 Mar 1;95(5):1600-7 [10688814] Haematologica. 2011 Mar;96(3):459-63 [21134978] Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10509-13 [10973484] Int Arch Allergy Immunol. 2002 Jun;128(2):136-41 [12065914] Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1477-84 [12433730] J Immunol. 2002 Dec 1;169(11):6452-8 [12444154] J Immunol. 2002 Dec 1;169(11):6459-66 [12444155] Allergy. 2003 May;58(5):371-9 [12752323] J Immunol. 2003 Jun 1;170(11):5359-66 [12759409] BMC Biotechnol. 2003 Sep 30;3:17 [14519208] Blood. 2004 Jun 1;103(11):4050-5 [14988154] Allergy. 2004 Oct;59(10):1087-96 [15355468] Int Arch Allergy Immunol. 2004 Sep;135(1):54-61 [15286446] Cell. 1991 Sep 20;66(6):1175-84 [1833065] Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7041-5 [1495999] J Immunol. 1997 Oct 15;159(8):4024-34 [9378992] Blood. 2005 Jan 15;105(2):592-9 [15367434] Eur J Haematol. 2006 Sep;77(3):181-90 [16856933] Blood. 2006 Oct 1;108(7):2366-72 [16741248] N Engl J Med. 2008 Mar 20;358(12):1215-28 [18344568] J Leukoc Biol. 2008 Aug;84(2):499-509 [18511572] Allergy. 2009 Feb;64(2):287-94 [19178408] N Engl J Med. 2009 Mar 5;360(10):973-84 [19264686] N Engl J Med. 2009 Mar 5;360(10):985-93 [19264687] Allergy. 2009 May;64(5):725-32 [19170670] BMC Pulm Med. 2009;9:34 [19602238] J Allergy Clin Immunol. 2010 Jun;125(6):1237-1244.e2 [20513521] J Allergy Clin Immunol. 2010 Jun;125(6):1336-43 [20513524] J Allergy Clin Immunol. 2010 Jun;125(6):1344-1353.e2 [20513525] Blood. 2000 Sep 15;96(6):2163-71 [10979962] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jaci.2011.05.032 ER - TY - JOUR T1 - Transforming growth factor β1 increase of hydroxysteroid dehydrogenase proteins is partly suppressed by red clover isoflavones in human primary prostate cancer-derived stromal cells. AN - 901306109; 21914638 AB - Transforming growth factor β1 (TGF-β1) increases dehydro-epiandrosterone (DHEA) metabolism to androgens and prostate-specific antigen (PSA) in a prostate tissue model where stromal (6S) cells and epithelial (LAPC-4) cells are cocultured. Red clover (RC) isoflavones inhibits transforming growth factor (TGF)-β-induced androgenicity. Mechanisms controlling those activities were explored. Three hydroxysteroid dehydrogenases (HSDs), 3β-HSD, HSD-17β1 and HSD-17β5 involved in metabolizing DHEA to testosterone (TESTO) were investigated. Individual depletion of HSDs in 6S cells significantly reduced TGF-β1/DHEA-induced PSA in LAPC-4 cells in cocultures. Monomer amounts of 3β-HSD were similar without or with TGF-β1 in both cell types but aggregates of 3β-HSD in 6S cells were much higher than those in LAPC-4 cells and were upregulated by TGFβ in 6S cells. Basal and TGF-β1-treated levels of HSD-17β1 and HSD-17β5 in LAPC-4 cells were significantly lower than in 6S cells, whereas levels of HSD-17β1 but not HSD-17β5 were TGFβ inducible. 6S cell HSD genes expression induced by TGFβ or androgen signaling was insignificant to contribute TGF-β1/DHEA-upregulated protein levels of HSDs. RC decreased TGF-β1- upregulation of aggregates of 3β-HSD but not HSD-17β1. Depletion of TGFβ receptors (TGFβ Rs) reduced TGF-β1/DHEA-upregulated HSDs and TESTO. Immunoprecipitation studies demonstrated that TGF-β1 disrupted associations of TGFβ Rs/HSDs aggregates, whereas RC suppressed the dissociations of aggregates of 3β-HSD but not HSD-17β1 from the receptors. Given that TGFβ Rs are recycled with or without ligand, TGF-β1-induced disassociation of the HSDs from TGFβ Rs may increase stability and activity of the HSDs. These data suggest a pathway connecting overproduction of TGFβ with increased PSA in prostate cancer. JF - Carcinogenesis AU - Liu, Xunxian AU - Piao, Yun-Shang AU - Arnold, Julia T AD - Endocrine Section, Intramural Research Program, National Center for Complementary and Alternative Medicine, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20892, USA. xunxianl@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 1648 EP - 1654 VL - 32 IS - 11 KW - Isoflavones KW - 0 KW - Receptors, Transforming Growth Factor beta KW - Transforming Growth Factor beta1 KW - Testosterone KW - 3XMK78S47O KW - 3-Hydroxysteroid Dehydrogenases KW - EC 1.1.- KW - Hydroxysteroid Dehydrogenases KW - AKR1C3 protein, human KW - EC 1.1.1.- KW - Hydroxyprostaglandin Dehydrogenases KW - Estradiol Dehydrogenases KW - EC 1.1.1.62 KW - HSD17B1 protein, human KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Index Medicus KW - Real-Time Polymerase Chain Reaction KW - Prostatic Neoplasms -- metabolism KW - Estradiol Dehydrogenases -- antagonists & inhibitors KW - Receptors, Transforming Growth Factor beta -- genetics KW - Prostate -- drug effects KW - Immunoblotting KW - 3-Hydroxysteroid Dehydrogenases -- metabolism KW - 3-Hydroxysteroid Dehydrogenases -- genetics KW - Humans KW - Receptors, Transforming Growth Factor beta -- metabolism KW - Prostate -- metabolism KW - Immunoprecipitation KW - Hydroxyprostaglandin Dehydrogenases -- antagonists & inhibitors KW - Prostatic Neoplasms -- drug therapy KW - Hydroxyprostaglandin Dehydrogenases -- metabolism KW - Prostatic Neoplasms -- pathology KW - Estradiol Dehydrogenases -- genetics KW - Estradiol Dehydrogenases -- metabolism KW - Hydroxyprostaglandin Dehydrogenases -- genetics KW - Cells, Cultured KW - Prostate-Specific Antigen -- metabolism KW - 3-Hydroxysteroid Dehydrogenases -- antagonists & inhibitors KW - Male KW - Testosterone -- metabolism KW - Stromal Cells -- drug effects KW - Isoflavones -- pharmacology KW - Hydroxysteroid Dehydrogenases -- metabolism KW - Hydroxysteroid Dehydrogenases -- genetics KW - Transforming Growth Factor beta1 -- pharmacology KW - Stromal Cells -- metabolism KW - Hydroxysteroid Dehydrogenases -- antagonists & inhibitors KW - Trifolium -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/901306109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Transforming+growth+factor+%CE%B21+increase+of+hydroxysteroid+dehydrogenase+proteins+is+partly+suppressed+by+red+clover+isoflavones+in+human+primary+prostate+cancer-derived+stromal+cells.&rft.au=Liu%2C+Xunxian%3BPiao%2C+Yun-Shang%3BArnold%2C+Julia+T&rft.aulast=Liu&rft.aufirst=Xunxian&rft.date=2011-11-01&rft.volume=32&rft.issue=11&rft.spage=1648&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgr206 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-22 N1 - Date created - 2011-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Prostate. 2000 Oct 1;45(2):140-8 [11027413] Prostate. 2011 May 15;71(7):766-77 [21031436] Nat Rev Mol Cell Biol. 2000 Dec;1(3):169-78 [11252892] J Urol. 2001 Dec;166(6):2472-83 [11696814] Clin Cancer Res. 2002 Sep;8(9):2912-23 [12231536] Mol Biol Cell. 2004 Sep;15(9):4166-78 [15229286] N Engl J Med. 1986 Dec 25;315(26):1650-9 [3537791] Ann N Y Acad Sci. 1994 May 31;719:553-63 [8010623] Steroids. 1996 Jan;61(1):41-6 [8789735] Exp Cell Res. 1997 May 1;232(2):208-15 [9168795] Prostate. 1999 Jun 1;39(4):285-90 [10344218] Mech Ageing Dev. 2005 Jan;126(1):59-69 [15610763] Curr Biol. 2005 Nov 22;15(22):1989-97 [16303557] Am J Physiol Endocrinol Metab. 2006 May;290(5):E952-60 [16368782] Nat Rev Cancer. 2006 Jul;6(7):506-20 [16794634] Endocrinology. 2006 Dec;147(12):5806-16 [16959841] Clin Dermatol. 2007 Jan-Feb;25(1):56-62 [17276202] Carcinogenesis. 2008 Apr;29(4):816-23 [18283040] Best Pract Res Clin Endocrinol Metab. 2008 Apr;22(2):207-21 [18471780] J Steroid Biochem Mol Biol. 2008 Sep;111(3-5):240-6 [18621129] ChemMedChem. 2008 Sep;3(9):1371-6 [18576452] Cancer Prev Res (Phila). 2009 Feb;2(2):134-42 [19141600] Mol Cell Endocrinol. 2009 Mar 25;301(1-2):83-8 [19013497] Clin Cancer Res. 2009 Aug 1;15(15):4815-22 [19638459] Endocr Relat Cancer. 2009 Dec;16(4):1139-55 [19608712] Trends Immunol. 2010 Jun;31(6):220-7 [20538542] J Mol Endocrinol. 2001 Feb;26(1):11-9 [11174850] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgr206 ER - TY - JOUR T1 - Immunological detection of N-formylkynurenine in porphyrin-mediated photooxided lens α-crystallin. AN - 900637813; 21770952 AB - Crystallin proteins are responsible for maintaining lens transparency and allowing the lens to focus light undistorted onto the retina. The α-crystallins are the major lens crystallins, and function as both structural proteins and chaperones to protect all lens proteins from damage leading to lens deterioration. Because lens crystallin proteins do not turn over, the damage they accumulate can lead to cataracts, the world's leading cause of blindness. Photosensitizing porphyrins can accumulate in the eye through either endogenous metabolism or through therapeutic or diagnostic procedures. Porphyrin buildup exacerbates lens aging through increased levels of singlet oxygen, resulting in protein polymerization and amino acid residue alteration. Tryptophans oxidize to kynurenine and N-formylkynurenine (NFK) causing irreversible changes in the refractive index of the normally transparent lens, leading to development of cataracts. Additionally, NFK is itself a photosensitizer, and its presence exacerbates lens deterioration. This work uses anti-NFK antiserum to study porphyrin-facilitated photooxidation of α-crystallin tryptophan residues. In vitro experiments show that four biologically interesting porphyrins mediate α-crystallin polymerization and accumulation of both protein radicals and NFK. Confocal microscopy of cultured human lens epithelial cells indicates that while all four porphyrins photosensitize cellular proteins, not all oxidize the tryptophans of cellular α-crystallin to NFK. © 2011 The Authors. Photochemistry and Photobiology © 2011 The American Society of Photobiology. JF - Photochemistry and photobiology AU - Ehrenshaft, Marilyn AU - Zhao, Baozhong AU - Andley, Usha P AU - Mason, Ronald P AU - Roberts, Joan E AD - Laboratory of Pharmacology and Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. ehrensh1@niehs.nih.gov PY - 2011 SP - 1321 EP - 1329 VL - 87 IS - 6 KW - Porphyrins KW - 0 KW - alpha-Crystallins KW - N'-formylkynurenine KW - 1022-31-7 KW - Kynurenine KW - 343-65-7 KW - Index Medicus KW - Oxidation-Reduction KW - Microscopy, Confocal KW - Refractometry KW - Humans KW - Cell Line KW - Photochemistry KW - Kynurenine -- analysis KW - alpha-Crystallins -- chemistry KW - Porphyrins -- chemistry KW - Kynurenine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900637813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Immunological+detection+of+N-formylkynurenine+in+porphyrin-mediated+photooxided+lens+%CE%B1-crystallin.&rft.au=Ehrenshaft%2C+Marilyn%3BZhao%2C+Baozhong%3BAndley%2C+Usha+P%3BMason%2C+Ronald+P%3BRoberts%2C+Joan+E&rft.aulast=Ehrenshaft&rft.aufirst=Marilyn&rft.date=2011-11-01&rft.volume=87&rft.issue=6&rft.spage=1321&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=1751-1097&rft_id=info:doi/10.1111%2Fj.1751-1097.2011.00979.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-25 N1 - Date created - 2011-10-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Photochem Photobiol. 2000 Aug;72(2):200-3 [10946573] Curr Opin Ophthalmol. 2011 Jan;22(1):4-9 [21107260] Exp Eye Res. 2003 Feb;76(2):145-53 [12565801] Free Radic Biol Med. 2003 Mar 15;34(6):637-47 [12633741] Biochem Biophys Res Commun. 2003 Jun 6;305(3):761-70 [12763058] Photochem Photobiol. 2003 May;77(5):567-71 [12812302] J Biol Chem. 2003 Jun 27;278(26):24078-89 [12686560] Photochem Photobiol Sci. 2004 Jan;3(1):17-25 [14743273] Curr Eye Res. 1985 Mar;4(3):181-5 [4017621] Lasers Surg Med. 1987;7(1):6-11 [3573938] Photochem Photobiol. 1987 Nov;46(5):683-8 [3441495] Photochem Photobiol. 1990 Apr;51(4):465-8 [2343063] Photochem Photobiol. 1990 Oct;52(4):761-8 [2089424] Photochem Photobiol. 1990 Oct;52(4):849-54 [2089434] Photochem Photobiol. 1991 Jan;53(1):33-8 [1851303] Biochemistry. 1991 Sep 3;30(35):8653-60 [1888728] Photochem Photobiol. 1991 Nov;54(5):855-7 [1798759] J Photochem Photobiol B. 1992 Feb 28;12(3):275-84 [1635012] Curr Eye Res. 1992 Nov;11(11):1121-5 [1336447] Invest Ophthalmol Vis Sci. 1994 Jun;35(7):3094-102 [8206728] Cancer Res. 1995 Jun 15;55(12):2620-6 [7780978] J Photochem Photobiol B. 1995 May;28(2):155-61 [7636637] Photochem Photobiol. 1995 Aug;62(2):339-41 [7480141] Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15185-9 [8986785] Protein Sci. 1998 Nov;7(11):2391-7 [9828005] Free Radic Biol Med. 2004 Dec 15;37(12):2018-26 [15544920] Biochim Biophys Acta. 2005 Jan 17;1703(2):93-109 [15680218] Prog Retin Eye Res. 2007 Jan;26(1):78-98 [17166758] Semin Liver Dis. 2007 Feb;27(1):99-108 [17295179] Int J Biochem Cell Biol. 2008;40(3):317-23 [18093866] Mol Cell Biochem. 2008 Mar;310(1-2):235-9 [18158587] Eur J Pharm Biopharm. 2008 Aug;69(3):1083-93 [18396019] Free Radic Biol Med. 2009 May 1;46(9):1260-6 [19353782] Free Radic Biol Med. 2009 Jul 1;47(1):92-102 [19375501] Photochem Photobiol. 2009 Nov-Dec;85(6):1306-13 [19709381] J Am Soc Mass Spectrom. 2010 Jul;21(7):1114-7 [20219394] Photochem Photobiol. 2010 Jul-Aug;86(4):752-6 [20408979] Free Radic Biol Med. 2010 Sep 15;49(6):1046-53 [20600836] Am J Physiol Endocrinol Metab. 2011 Jun;300(6):E1047-58 [21386058] Photochem Photobiol. 2001 Nov;74(5):740-4 [11723804] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1751-1097.2011.00979.x ER - TY - JOUR T1 - Genomic-derived markers for early detection of calcineurin inhibitor immunosuppressant-mediated nephrotoxicity. AN - 900627565; 21865292 AB - Calcineurin inhibitor (CI) therapy has been associated with chronic nephrotoxicity, which limits its long-term utility for suppression of allograft rejection. In order to understand the mechanisms of the toxicity, we analyzed gene expression changes that underlie the development of CI immunosuppressant-mediated nephrotoxicity in male Sprague-Dawley rats dosed daily with cyclosporine (CsA; 2.5 or 25 mg/kg/day), FK506 (0.6 or 6 mg/kg/day), or rapamycin (1 or 10 mg/kg/day) for 1, 7, 14, or 28 days. A significant increase in blood urea nitrogen was observed in animals treated with CsA (high) or FK506 (high) for 14 and 28 days. Histopathological examination revealed tubular basophilia and mineralization in animals given CsA (high) or FK506 (low and high). We identified a group of genes whose expression in rat kidney is correlated with CI-induced kidney injury. Among these genes are two genes, Slc12a3 and kidney-specific Wnk1 (KS-Wnk1), that are known to be involved in sodium transport in the distal nephrons and could potentially be involved in the mechanism of CI-induced nephrotoxicity. The downregulation of NCC (the Na-Cl cotransporter coded by Slc12a3) in rat kidney following CI treatment was confirmed by immunohistochemical staining, and the downregulation of KS-Wnk1 was confirmed by quantitative real-time-polymerase chain reaction (qRT-PCR). We hypothesize that decreased expression of Slc12a3 and KS-Wnk1 could alter the sodium chloride reabsorption in the distal tubules and contribute to the prolonged activation of the renin-angiotensin system, a demonstrated contributor to the development of CI-induced nephrotoxicity in both animal models and clinical settings. Therefore, if validated as biomarkers in humans, SLC12A3 and KS-WNK1 could potentially be useful in the early detection and reduction of CI-related nephrotoxicity in immunosuppressed transplant patients when monitoring the health of kidney xenographs in clinical practice. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Cui, Yuxia AU - Huang, Qihong AU - Auman, James Todd AU - Knight, Brian AU - Jin, Xidong AU - Blanchard, Kerry T AU - Chou, Jeff AU - Jayadev, Supriya AU - Paules, Richard S AD - Environmental Stress and Cancer Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 23 EP - 34 VL - 124 IS - 1 KW - Calcineurin Inhibitors KW - 0 KW - Genetic Markers KW - Immunosuppressive Agents KW - Minor Histocompatibility Antigens KW - Receptors, Drug KW - Slc12a3 protein, rat KW - Solute Carrier Family 12, Member 3 KW - Symporters KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - Wnk1 protein, rat KW - Index Medicus KW - Animals KW - Kidney -- metabolism KW - Kidney -- pathology KW - Kidney Transplantation KW - Kidney -- drug effects KW - Graft Rejection -- prevention & control KW - Rats KW - Rats, Sprague-Dawley KW - Down-Regulation KW - Chronic Disease KW - Renin-Angiotensin System -- drug effects KW - Early Diagnosis KW - Immunohistochemistry KW - Male KW - Receptors, Drug -- genetics KW - Kidney Diseases -- physiopathology KW - Kidney Diseases -- pathology KW - Kidney Diseases -- genetics KW - Symporters -- genetics KW - Immunosuppressive Agents -- toxicity KW - Protein-Serine-Threonine Kinases -- genetics KW - Immunosuppressive Agents -- therapeutic use KW - Kidney Diseases -- chemically induced KW - Immunosuppressive Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900627565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Genomic-derived+markers+for+early+detection+of+calcineurin+inhibitor+immunosuppressant-mediated+nephrotoxicity.&rft.au=Cui%2C+Yuxia%3BHuang%2C+Qihong%3BAuman%2C+James+Todd%3BKnight%2C+Brian%3BJin%2C+Xidong%3BBlanchard%2C+Kerry+T%3BChou%2C+Jeff%3BJayadev%2C+Supriya%3BPaules%2C+Richard+S&rft.aulast=Cui&rft.aufirst=Yuxia&rft.date=2011-11-01&rft.volume=124&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfr217 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-12 N1 - Date created - 2011-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Hepatol. 2011 May;54(5):1041-54 [21145927] Transplantation. 2011 Jan 15;91(1):115-20 [21452415] J Am Soc Nephrol. 2000 Dec;11(12):2265-71 [11095649] Nephrol Dial Transplant. 2001 Feb;16(2):378-82 [11158416] Science. 2001 Aug 10;293(5532):1107-12 [11498583] Transplantation. 2001 Sep 15;72(5):777-86 [11571437] Transplantation. 2001 Dec 15;72(11):1826-9 [11740395] Curr Opin Crit Care. 2001 Dec;7(6):384-9 [11805539] Curr Drug Metab. 2002 Feb;3(1):61-71 [11876576] Nephron. 2002 Dec;92(4):914-21 [12399639] Kidney Int. 2002 Dec;62(6):2055-61 [12427129] Int J Mol Med. 2003 Jan;11(1):75-8 [12469222] J Am Soc Nephrol. 2004 Mar;15(3):549-57 [14978156] Nephron Physiol. 2004;96(3):p65-78 [15056980] Transplantation. 2004 Aug 27;78(4):557-65 [15446315] Proc Natl Acad Sci U S A. 1981 Dec;78(12):7579-83 [6278480] Science. 1987 Sep 25;237(4822):1618-20 [3306925] Am J Physiol. 1987 Dec;253(6 Pt 2):H1596-600 [3322045] Transplantation. 1988 Aug;46(2):285-92 [3406978] Am J Physiol. 1991 Apr;260(4 Pt 2):F486-93 [2012204] Kidney Int. 1993 Mar;43(3):615-22 [8455360] J Am Soc Nephrol. 1993 Aug;4(2):214-21 [8400085] Clin Exp Pharmacol Physiol. 1995 Sep;22(9):646-54 [8542679] Lab Invest. 1995 Dec;73(6):794-803 [8558840] Nat Genet. 1996 Jan;12(1):24-30 [8528245] J Am Soc Nephrol. 1995 Oct;6(4):1186-96 [8589285] J Hypertens. 1996 Jul;14(7):815-22 [8818919] Biochem Pharmacol. 1997 Mar 7;53(5):723-31 [9113092] Kidney Int. 1997 Jul;52(1):248-60 [9211371] Am J Kidney Dis. 1997 Jul;30(1):71-81 [9214404] Transplantation. 1997 Aug 15;64(3):436-43 [9275110] J Biol Chem. 1998 Oct 30;273(44):29150-5 [9786924] Transplantation. 1998 Dec 27;66(12):1736-40 [9884269] Nephron Exp Nephrol. 2005;99(1):e9-16 [15637465] Toxicol Pathol. 2005;33(3):343-55 [15805072] J Bioinform Comput Biol. 2005 Apr;3(2):225-41 [15852502] J Clin Invest. 2005 May;115(5):1379-87 [15841204] Adv Chronic Kidney Dis. 2006 Jan;13(1):47-55 [16412970] Am J Physiol Renal Physiol. 2006 Mar;290(3):F619-24 [16204408] Am J Transplant. 2006;6(5 Pt 2):1111-31 [16613591] Curr Hypertens Rep. 2006 May;8(2):158-65 [16672150] Eur J Clin Invest. 2006 Nov;36(11):753-63 [17032342] J Am Soc Nephrol. 2007 Feb;18(2):421-9 [17202415] Pharmacol Rev. 2007 Sep;59(3):251-87 [17878513] BMC Bioinformatics. 2007;8:427 [17980031] Kidney Int. 2008 Mar;73(5):608-14 [18160964] Kidney Int. 2008 Mar;73(5):522-3 [18274540] Hypertension. 2008 Mar;51(3):588-96 [18212265] J Cell Sci. 2008 Mar 1;121(Pt 5):675-84 [18270262] Toxicology. 2008 Apr 18;246(2-3):91-100 [18289764] Urology. 2008 Apr;71(4):630-3 [18387391] Chin Med J (Engl). 2008 Jun 5;121(11):983-8 [18706245] Clin J Am Soc Nephrol. 2009 Feb;4(2):481-508 [19218475] Transplantation. 2010 Mar 15;89(5):537-47 [20147884] Transplant Proc. 2010 Mar;42(2):473-4 [20304168] Pharmacogenomics. 2010 Oct;11(10):1491-501 [21047207] Transplant Proc. 2010 Nov;42(9 Suppl):S21-4 [21095445] J Biol Chem. 2000 Jun 2;275(22):16795-801 [10828064] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfr217 ER - TY - JOUR T1 - Potentiation of platelet-derived growth factor receptor-β signaling mediated by integrin-associated MFG-E8. AN - 900627512; 21868707 AB - Pericytes/pericyte precursors produce milk fat globule-associated protein with epidermal growth factor and factor VIII-like domains (MFG-E8) in vivo, and this α(v) integrin ligand enhances angiogenesis in tumors and in oxygen-induced retinopathy in mice. Inhibition of MFG-E8 production or function attenuates platelet-derived growth factor-BB (PDGF-BB)-induced migration of pericyte/pericyte precursor-like 10T1/2 cells in vitro. Herein, we describe mechanisms by which MFG-E8 modulates PDGF-BB:PDGF receptor β (PDGFRβ) signaling in 10T1/2 cells. Small interfering RNA depletion of MFG-E8 from 10T1/2 cells or antibody inhibition of MFG-E8 action enhanced PDGF-BB-dependent degradation of PDGFRβ and attenuated signaling. Coimmunoprecipitation revealed transient association of MFG-E8 with PDGFRβ in PDGF-BB-treated 10T1/2 cells and reduced PDGFRβ-focal adhesion kinase association in MFG-E8-depleted cells. Confocal microscopy demonstrated that MFG-E8 binding to 10T1/2 cells was RGD motif and α(v) dependent but PDGF-BB treatment independent, whereas colocalization of MFG-E8 with PDGFRβ was enhanced by PDGF-BB. Ubiquitination of PDGFRβ was also increased in MFG-E8 small interfering RNA-transfected cells. Integrin α(v)-bound MFG-E8 associates with PDGFRβ and focal adhesion kinase after PDGF-BB treatment, results in cell surface retention of PDGFRβ, delays receptor degradation, potentiates downstream signaling, and enhances migration of 10T1/2 cells. MFG-E8 may promote angiogenesis, in part, via cell autonomous actions on pericytes or pericyte precursors that result in enhanced PDGF-BB:PDGFRβ signaling mediated via integrin-growth factor receptor cross-talk. JF - Arteriosclerosis, thrombosis, and vascular biology AU - Motegi, Sei-ichiro AU - Garfield, Susan AU - Feng, Xu AU - Sárdy, Miklós AU - Udey, Mark C AD - Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20802-1908, USA. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 2653 EP - 2664 VL - 31 IS - 11 KW - Antigens, Surface KW - 0 KW - Integrin alphaV KW - Mfge8 protein, mouse KW - Milk Proteins KW - Platelet-Derived Growth Factor KW - Proto-Oncogene Proteins c-sis KW - RNA, Small Interfering KW - becaplermin KW - 1B56C968OA KW - Receptor, Platelet-Derived Growth Factor beta KW - EC 2.7.10.1 KW - Focal Adhesion Kinase 1 KW - EC 2.7.10.2 KW - Ptk2 protein, mouse KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Models, Animal KW - Animals KW - Platelet-Derived Growth Factor -- metabolism KW - Platelet-Derived Growth Factor -- pharmacology KW - Mice KW - Extracellular Signal-Regulated MAP Kinases -- metabolism KW - Cells, Cultured KW - Cell Movement -- physiology KW - Phosphorylation -- physiology KW - Cell Movement -- drug effects KW - Mice, Inbred C3H KW - RNA, Small Interfering -- pharmacology KW - Focal Adhesion Kinase 1 -- metabolism KW - Cell Line KW - Embryonic Stem Cells -- cytology KW - Integrin alphaV -- metabolism KW - Pericytes -- metabolism KW - Receptor, Platelet-Derived Growth Factor beta -- metabolism KW - Pericytes -- cytology KW - Milk Proteins -- metabolism KW - Pericytes -- drug effects KW - Signal Transduction -- physiology KW - Embryonic Stem Cells -- drug effects KW - Embryonic Stem Cells -- metabolism KW - Milk Proteins -- antagonists & inhibitors KW - Antigens, Surface -- drug effects KW - Antigens, Surface -- metabolism KW - Milk Proteins -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900627512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arteriosclerosis%2C+thrombosis%2C+and+vascular+biology&rft.atitle=Potentiation+of+platelet-derived+growth+factor+receptor-%CE%B2+signaling+mediated+by+integrin-associated+MFG-E8.&rft.au=Motegi%2C+Sei-ichiro%3BGarfield%2C+Susan%3BFeng%2C+Xu%3BS%C3%A1rdy%2C+Mikl%C3%B3s%3BUdey%2C+Mark+C&rft.aulast=Motegi&rft.aufirst=Sei-ichiro&rft.date=2011-11-01&rft.volume=31&rft.issue=11&rft.spage=2653&rft.isbn=&rft.btitle=&rft.title=Arteriosclerosis%2C+thrombosis%2C+and+vascular+biology&rft.issn=1524-4636&rft_id=info:doi/10.1161%2FATVBAHA.111.233619 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-23 N1 - Date created - 2011-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1161/ATVBAHA.111.233619 ER - TY - JOUR T1 - Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of SMADS and TAK1 in early mouse embryo. AN - 900625772; 21953618 AB - Hepatocyte growth factor-regulated tyrosine kinase substrate that is encoded by Hgs promotes degradation of ubiquitinated signaling molecule in the early endosome. We previously reported that a targeted mutation in Hgs results in embryonic lethality soon after gastrulation in the mouse. Here, we report that downstream target genes for BMP signaling were highly down-regulated in the Hgs mutant embryos. We also showed that Hgs is required for phosphorylation of SMAD1/5/8 and TAK1/p38 to transduce BMP signaling. Furthermore, we found that HGS functions to localize TAK1 in early endosome for its activation. These results suggest that HGS is critical to localize TAK1 to early endosome for transducing BMP signaling for proper development. Our data revealed a new mechanism to modify BMP signaling by Hgs during early mouse development. Copyright © 2011 Wiley-Liss, Inc. JF - Developmental dynamics : an official publication of the American Association of Anatomists AU - Miura, Shigeto AU - Mishina, Yuji AD - Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 2474 EP - 2481 VL - 240 IS - 11 KW - Bmp4 protein, mouse KW - 0 KW - Bone Morphogenetic Protein 4 KW - Bone Morphogenetic Proteins KW - Endosomal Sorting Complexes Required for Transport KW - Phosphoproteins KW - Smad Proteins KW - hepatocyte growth factor-regulated tyrosine kinase substrate KW - MAP Kinase Kinase Kinases KW - EC 2.7.11.25 KW - MAP kinase kinase kinase 7 KW - Index Medicus KW - Bone Morphogenetic Protein 4 -- genetics KW - Signal Transduction -- physiology KW - Animals KW - Phosphorylation KW - Signal Transduction -- genetics KW - Bone Morphogenetic Protein 4 -- metabolism KW - Mice KW - Tissue Distribution KW - Models, Biological KW - Protein Transport KW - Mice, Knockout KW - Embryonic Development -- genetics KW - MAP Kinase Kinase Kinases -- metabolism KW - Smad Proteins -- metabolism KW - Phosphoproteins -- genetics KW - Blastocyst -- metabolism KW - Endosomal Sorting Complexes Required for Transport -- physiology KW - Phosphoproteins -- physiology KW - Bone Morphogenetic Proteins -- physiology KW - Bone Morphogenetic Proteins -- metabolism KW - Endosomal Sorting Complexes Required for Transport -- metabolism KW - Endosomal Sorting Complexes Required for Transport -- genetics KW - Phosphoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900625772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+dynamics+%3A+an+official+publication+of+the+American+Association+of+Anatomists&rft.atitle=Hepatocyte+growth+factor-regulated+tyrosine+kinase+substrate+%28Hgs%29+is+involved+in+BMP+signaling+through+phosphorylation+of+SMADS+and+TAK1+in+early+mouse+embryo.&rft.au=Miura%2C+Shigeto%3BMishina%2C+Yuji&rft.aulast=Wentzensen&rft.aufirst=Nicolas&rft.date=2011-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Scientific+Meeting+of+the+American+Society+of+Cytopathology+%28ASC+2011%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-16 N1 - Date created - 2011-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Development. 2007 Sep;134(18):3359-69 [17699604] Cancer Res. 2007 Jun 1;67(11):5162-71 [17545595] J Cell Biol. 2009 Jan 26;184(2):323-34 [19153222] Endocrinology. 2009 Nov;150(11):4989-98 [19819979] Differentiation. 2010 Feb;79(2):84-92 [19889495] Dev Biol. 2010 May 1;341(1):246-54 [20211162] Nature. 2000 Mar 2;404(6773):95-9 [10716450] Mol Cell Biol. 2000 Dec;20(24):9346-55 [11094085] Development. 2001 Jan;128(2):155-66 [11124112] J Biol Chem. 2001 Aug 10;276(32):29943-52 [11397816] J Cell Sci. 2001 Jun;114(Pt 12):2255-63 [11493665] Cell. 2002 Jan 25;108(2):261-9 [11832215] Genes Cells. 2002 Mar;7(3):321-31 [11918675] Sci STKE. 2002 Sep 24;2002(151):pe40 [12297674] Front Biosci. 2003 May 1;8:d855-69 [12700086] Cell. 2003 Oct 31;115(3):281-92 [14636556] Dev Biol. 2004 Jun 1;270(1):47-63 [15136140] Development. 2004 Jun;131(11):2749-62 [15148304] Development. 2004 Aug;131(15):3501-12 [15215210] Cell. 1991 Mar 8;64(5):915-25 [1900457] Development. 1992 Dec;116(4):1123-36 [1363541] Development. 1994 Jul;120(7):1919-28 [7924997] Dev Dyn. 1995 Jun;203(2):163-73 [7655079] Genes Dev. 1995 Sep 1;9(17):2105-16 [7657163] Mech Dev. 1996 Apr;55(2):185-99 [8861098] Mol Biol Cell. 1996 Mar;7(3):355-67 [8868465] Dev Dyn. 1996 Nov;207(3):235-52 [8922523] J Biol Chem. 1997 Aug 15;272(33):20538-44 [9252367] Mech Dev. 1997 Nov;68(1-2):45-57 [9431803] EMBO J. 1998 Feb 16;17(4):1019-28 [9463380] Genes Dev. 1998 Mar 15;12(6):844-57 [9512518] Cell. 1998 Oct 30;95(3):379-91 [9814708] EMBO J. 1999 Jan 4;18(1):179-87 [9878061] Nature. 1999 Mar 18;398(6724):252-6 [10094049] Genes Dev. 1999 Jun 1;13(11):1475-85 [10364163] Nat Genet. 1999 Aug;22(4):361-5 [10431240] Dev Biol. 2004 Dec 1;276(1):185-93 [15531373] Cytokine Growth Factor Rev. 2005 Jun;16(3):265-78 [15871922] Development. 2006 Apr;133(8):1529-41 [16556914] J Mol Cell Cardiol. 2006 Jul;41(1):26-33 [16716349] Dev Biol. 2006 Aug 15;296(2):458-75 [16839541] Dev Cell. 2006 Sep;11(3):313-23 [16950123] Development. 2006 Oct;133(19):3767-75 [16943278] J Biol Chem. 2007 Mar 2;282(9):6075-89 [17197697] Oncogene. 2007 May 14;26(22):3214-26 [17496917] Nat Chem Biol. 2008 Jan;4(1):33-41 [18026094] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/dvdy.22750 ER - TY - JOUR T1 - Quantitative analysis of AgNOR proteins in buccal epithelial cells of Indian street boys addicted to gasp 'golden glue' AN - 899165882; 15795526 AB - The effect of glue snuffle on the expression of argyrophilic nucleolar organizer regions (AgNORs), an indicator of ribosome biosynthesis, in epithelial cells of oral mucosa has been investigated. AgNOR was evaluated by cytochemical staining in 148 Indian street boys (median age 12 year) who had different bad addictions like tobacco smoking, chewing and most importantly inhaling glue and 20 age- and body mass index-matched school boys who had no such type of bad habit. Compared with school boys, glue addicted street boys showed remarkably increased number of AgNOR dots per nucleus (9.38 +/- 1.84 vs. 3.12 +/- 0.87, p 0.001), AgNOR size (1.34 +/- 0.52 vs. 0.43 +/- 0.02 mu m super(2, p 0.001) and percentage of AgNOR occupied nuclear area (9.38 +/- 2.12 vs. 0.99 +/- 0.03%, p 0.001). Increase in number and size of the dots is also higher in tobacco smokers and chewers when compared with school boys but a remarkable difference was recorded in glue addicted boys. The changes in AgNOR expression were positively associated with years of addiction after controlling potential confounders. Thus, glue snuffle appeared to be a risk factor for abnormal cell growth via up-regulation of ribosome biogenesis.) JF - Experimental and Toxicologic Pathology AU - Mondal, Nandan Kumar AU - Ghosh, Sreenita AU - Ray, Manas Ranjan AD - Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700 026, India, nandan_gm@yahoo.com Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 677 EP - 681 PB - Elsevier B.V., P.O. Box 100537 Jena D-07705 Germany VL - 63 IS - 7-8 SN - 0940-2993, 0940-2993 KW - Toxicology Abstracts KW - Tobacco smoking KW - Epithelial cells KW - Age KW - Nucleoli KW - Chewing KW - Body mass KW - Mucosa KW - Ribosomes KW - Risk factors KW - Addiction KW - Nuclei KW - Drug addiction KW - Adhesives KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899165882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+Toxicologic+Pathology&rft.atitle=Quantitative+analysis+of+AgNOR+proteins+in+buccal+epithelial+cells+of+Indian+street+boys+addicted+to+gasp+%27golden+glue%27&rft.au=Mondal%2C+Nandan+Kumar%3BGhosh%2C+Sreenita%3BRay%2C+Manas+Ranjan&rft.aulast=Mondal&rft.aufirst=Nandan&rft.date=2011-11-01&rft.volume=63&rft.issue=7-8&rft.spage=677&rft.isbn=&rft.btitle=&rft.title=Experimental+and+Toxicologic+Pathology&rft.issn=09402993&rft_id=info:doi/10.1016%2Fj.etp.2010.05.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Tobacco smoking; Nucleoli; Age; Chewing; Body mass; Mucosa; Ribosomes; Risk factors; Addiction; Adhesives; Drug addiction; Nuclei DO - http://dx.doi.org/10.1016/j.etp.2010.05.010 ER - TY - JOUR T1 - The Escherichia coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis. AN - 898509015; 21908668 AB - Manganese is a critical micronutrient for cells, serving as an enzyme cofactor and protecting against oxidative stress. Yet, manganese is toxic in excess and little is known about its distribution in cells. Bacteria control intracellular manganese levels by the transcription regulator MntR. When this work began, the only Escherichia coli K-12 gene known to respond to manganese via MntR repression was mntH, which encodes a manganese importer. We show that mntS (formerly the small RNA gene rybA) is repressed by manganese through MntR and encodes an unannotated 42-amino-acid protein. Overproduction of MntS causes manganese sensitivity, while a lack of MntS perturbs proper manganese-dependent repression of mntH. We also provide evidence that mntP (formerly yebN), which encodes a putative efflux pump, is positively regulated by MntR. Deletion of mntP leads to profound manganese sensitivity and to elevated intracellular manganese levels. This work thus defines two new proteins involved in manganese homeostasis and suggests mechanisms for their action. JF - Journal of bacteriology AU - Waters, Lauren S AU - Sandoval, Melissa AU - Storz, Gisela AD - Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 5887 EP - 5897 VL - 193 IS - 21 KW - Escherichia coli Proteins KW - 0 KW - Membrane Transport Proteins KW - MntP protein, E coli KW - MntR protein, E coli KW - MntS protein, E coli KW - Repressor Proteins KW - Manganese KW - 42Z2K6ZL8P KW - Index Medicus KW - Homeostasis KW - Gene Deletion KW - Gene Expression Regulation, Bacterial KW - Escherichia coli K12 -- genetics KW - Manganese -- metabolism KW - Escherichia coli Proteins -- metabolism KW - Repressor Proteins -- metabolism KW - Repressor Proteins -- genetics KW - Membrane Transport Proteins -- metabolism KW - Membrane Transport Proteins -- genetics KW - Escherichia coli Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/898509015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=The+Escherichia+coli+MntR+miniregulon+includes+genes+encoding+a+small+protein+and+an+efflux+pump+required+for+manganese+homeostasis.&rft.au=Waters%2C+Lauren+S%3BSandoval%2C+Melissa%3BStorz%2C+Gisela&rft.aulast=Waters&rft.aufirst=Lauren&rft.date=2011-11-01&rft.volume=193&rft.issue=21&rft.spage=5887&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=1098-5530&rft_id=info:doi/10.1128%2FJB.05872-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-06 N1 - Date created - 2011-10-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 2006 Apr 7;125(1):71-84 [16615891] J Bacteriol. 2005 Oct;187(20):6962-71 [16199566] J Bacteriol. 2007 Mar;189(5):2101-9 [17172335] Biometals. 2007 Jun;20(3-4):485-99 [17216355] PLoS Biol. 2007 Apr;5(4):e92 [17373858] Cell. 2007 Sep 7;130(5):878-92 [17803910] Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20454-9 [18042713] BMC Genomics. 2007;8:347 [17908319] ISME J. 2008 Apr;2(4):393-403 [18273068] Mol Microbiol. 2008 Dec;70(5):1076-93 [18710431] Nat Rev Microbiol. 2009 Jan;7(1):25-35 [19079350] Mol Microbiol. 2008 Dec;70(6):1487-501 [19121005] Genes Dev. 2009 Feb 15;23(4):522-34 [19240136] Mol Microbiol. 2009 Apr;72(1):12-25 [19226324] Mol Microbiol. 2009 May;72(4):844-58 [19400769] Genes Dev. 2009 Nov 15;23(22):2650-62 [19933154] J Bacteriol. 2010 Jan;192(1):59-67 [19734312] J Bacteriol. 2010 Mar;192(5):1433-43 [19915021] Mol Microbiol. 2010 Feb;75(3):637-57 [20015147] PLoS One. 2010;5(9):e12570 [20838443] BMC Microbiol. 2010;10:319 [21156049] J Bacteriol. 2011 Mar;193(6):1477-80 [21239586] Biochemistry. 2011 Mar 15;50(10):1672-81 [21250660] Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5402-7 [21402925] Mol Microbiol. 2011 Apr;80(2):319-34 [21338418] Microbiology. 2001 Jul;147(Pt 7):1709-18 [11429449] Mol Microbiol. 2000 Mar;35(6):1454-68 [10760146] Proc Natl Acad Sci U S A. 2000 May 23;97(11):5978-83 [10811905] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5 [10829079] Mol Microbiol. 2000 Jun;36(5):1085-100 [10844693] Genes Dev. 2001 Jul 1;15(13):1637-51 [11445539] J Bacteriol. 2001 Aug;183(16):4806-13 [11466284] J Bacteriol. 2002 Jun;184(12):3151-8 [12029030] Mol Microbiol. 2002 Jun;44(5):1269-86 [12028379] Mol Microbiol. 2002 Jul;45(2):333-49 [12123448] Trends Microbiol. 2002 Nov;10(11):496-501 [12419613] Science. 2003 May 9;300(5621):931-6 [12738850] FEMS Microbiol Rev. 2003 Jun;27(2-3):263-90 [12829271] Nat Struct Biol. 2003 Aug;10(8):652-7 [12847518] Mol Microbiol. 2003 Sep;49(6):1477-91 [12950915] Biochemistry. 2003 Nov 4;42(43):12634-42 [14580210] Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6421-6 [15096624] J Proteome Res. 2004 May-Jun;3(3):463-8 [15253427] J Bacteriol. 2004 Oct;186(20):6698-705 [15466020] J Mol Biol. 1994 Feb 18;236(2):531-45 [8107138] Gene. 1995 May 26;158(1):9-14 [7789817] J Bacteriol. 1995 Jul;177(14):4121-30 [7608087] Science. 2004 Nov 5;306(5698):1025-8 [15459345] J Bacteriol. 2005 Feb;187(3):912-22 [15659669] J Bacteriol. 2005 Apr;187(8):2912-6 [15805538] Annu Rev Microbiol. 2006;60:187-209 [16704341] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JB.05872-11 ER - TY - JOUR T1 - Expression profiling of difficult-to-diagnose thyroid histologic subtypes shows distinct expression profiles and identify candidate diagnostic microRNAs. AN - 898503826; 21553140 AB - The incidence of thyroid cancer is increasing worldwide. The findings of up to 30% of thyroid fine-needle aspiration biopsies (FNAB) are inconclusive, primarily as a result of several thyroid histologic subtypes with overlapping cytologic features. MicroRNAs (miRNAs) are small noncoding RNAs and have been implicated in carcinogenesis. We hypothesized that there are miRNAs that are differentially expressed between benign and malignant thyroid tumors that are difficult to distinguish by FNAB. The expression of 1263 human miRNAs was profiled in 47 tumor samples representing difficult to diagnose histologic subtypes of thyroid neoplasm (21 benign, 26 malignant). Differentially expressed miRNAs were validated by quantitative real-time reverse transcriptase-polymerase chain reaction. The area under the receiver operating characteristic curve (AUC) was used to determine the diagnostic accuracy of differentially expressed miRNAs. Supervised hierarchical cluster analysis demonstrated grouping of 2 histologies (papillary and follicular thyroid carcinoma). A total of 34 miRNAs were differentially expressed in malignant compared to benign thyroid neoplasms (P0.7. miR-7 and miR-126 had the highest diagnostic accuracy with AUCs values of 0.81 and 0.77, respectively. To our knowledge, this is the first study to evaluate the diagnostic accuracy of miRNAs in thyroid histologies that are difficult to distinguish as benign or malignant by FNAB. miR-126 and miR-7 had high diagnostic accuracy and could be helpful adjuncts to thyroid FNAB. JF - Annals of surgical oncology AU - Kitano, Mio AU - Rahbari, Reza AU - Patterson, Erin E AU - Xiong, Yin AU - Prasad, Nijaguna B AU - Wang, Yongchun AU - Zeiger, Martha A AU - Kebebew, Electron AD - Endocrine Oncology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 3443 EP - 3452 VL - 18 IS - 12 KW - Biomarkers, Tumor KW - 0 KW - MicroRNAs KW - Index Medicus KW - Real-Time Polymerase Chain Reaction KW - Biopsy, Fine-Needle KW - ROC Curve KW - Oligonucleotide Array Sequence Analysis KW - Area Under Curve KW - Humans KW - Prognosis KW - Thyroid Neoplasms -- diagnosis KW - Gene Expression Profiling KW - Biomarkers, Tumor -- genetics KW - Thyroid Neoplasms -- classification KW - Thyroid Neoplasms -- genetics KW - MicroRNAs -- genetics KW - Adenocarcinoma, Follicular -- diagnosis KW - Adenocarcinoma, Follicular -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/898503826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+surgical+oncology&rft.atitle=Expression+profiling+of+difficult-to-diagnose+thyroid+histologic+subtypes+shows+distinct+expression+profiles+and+identify+candidate+diagnostic+microRNAs.&rft.au=Kitano%2C+Mio%3BRahbari%2C+Reza%3BPatterson%2C+Erin+E%3BXiong%2C+Yin%3BPrasad%2C+Nijaguna+B%3BWang%2C+Yongchun%3BZeiger%2C+Martha+A%3BKebebew%2C+Electron&rft.aulast=Kitano&rft.aufirst=Mio&rft.date=2011-11-01&rft.volume=18&rft.issue=12&rft.spage=3443&rft.isbn=&rft.btitle=&rft.title=Annals+of+surgical+oncology&rft.issn=1534-4681&rft_id=info:doi/10.1245%2Fs10434-011-1766-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-02-07 N1 - Date created - 2011-10-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Med Oncol. 2011 Dec;28(4):1054-7 [20680522] Biochem Biophys Res Commun. 2009 Feb 13;379(3):726-31 [19116145] Thyroid. 2011 Mar;21(3):243-51 [21190442] J Clin Endocrinol Metab. 2009 Jun;94(6):2092-8 [19318445] Thyroid. 2009 Jul;19(7):717-23 [19485775] Cancer. 2009 Jun 25;117(3):195-202 [19382174] Surg Clin North Am. 2009 Oct;89(5):1139-55 [19836489] Future Oncol. 2009 Oct;5(8):1283-93 [19852742] Lung Cancer. 2009 Nov;66(2):169-75 [19223090] Thyroid. 2009 Nov;19(11):1167-214 [19860577] Thyroid. 2009 Nov;19(11):1215-23 [19888859] J Clin Oncol. 2009 Dec 1;27(34):5848-56 [19884536] Curr Opin Oncol. 2010 Jan;22(1):23-9 [19907326] Thyroid. 2009 Dec;19(12):1351-61 [19895341] Br J Cancer. 2010 Jan 19;102(2):376-82 [20029416] Cancer Metastasis Rev. 2009 Dec;28(3-4):369-78 [20012925] Biochem Biophys Res Commun. 2010 Jan 15;391(3):1483-9 [20034472] Endocr Relat Cancer. 2010 Mar;17(1):F91-104 [19942715] Endocr Metab Immune Disord Drug Targets. 2010 Mar;10(1):47-56 [20088814] Biochem Biophys Res Commun. 2010 Apr 16;394(4):921-7 [20230785] Thyroid. 2010 May;20(5):489-94 [20406109] Otolaryngol Clin North Am. 2010 Apr;43(2):257-71, vii-viii [20510713] J Endocrinol Invest. 2010;33(5 Suppl):51-6 [20543551] Am J Surg. 2010 Jul;200(1):41-6 [20637335] Clin Oncol (R Coll Radiol). 2010 Aug;22(6):395-404 [20627675] Endocr Relat Cancer. 2010 Sep;17(3):835-46 [20621999] Med Clin North Am. 2010 Sep;94(5):1003-15 [20736109] Cancer Lett. 2010 Dec 1;298(1):50-63 [20619534] World J Surg. 2010 Nov;34(11):2589-94 [20703476] Biochem J. 2010 Nov 15;432(1):199-205 [20819078] Endocr Pract. 2003 Mar-Apr;9(2):128-36 [12917075] Am J Med. 1982 Sep;73(3):381-4 [7124765] Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19075-80 [16365291] Curr Opin Genet Dev. 2006 Feb;16(1):4-9 [16361094] Endocr Relat Cancer. 2006 Jun;13(2):497-508 [16728577] Oncogene. 2006 Oct 9;25(46):6163-9 [17028595] Nat Genet. 2007 May;39(5):582-3 [17460676] Clin Endocrinol (Oxf). 2007 May;66(5):678-83 [17381488] Endocr Relat Cancer. 2007 Sep;14(3):791-8 [17914108] Cancer. 2007 Oct 25;111(5):306-15 [17680588] Curr Opin Oncol. 2008 Jan;20(1):13-8 [18043251] Oncogene. 2007 Nov 29;26(54):7590-5 [17563749] Endocr Pathol. 2007 Fall;18(3):163-73 [18058265] Nature. 2008 Jan 10;451(7175):147-52 [18185580] J Clin Endocrinol Metab. 2008 May;93(5):1600-8 [18270258] Cancer Res. 2008 May 15;68(10):3566-72 [18483236] Diagn Cytopathol. 2008 Jun;36(6):390-9 [18478607] Mod Pathol. 2008 Sep;21(9):1139-46 [18587330] Thyroid. 2008 Sep;18(9):933-41 [18788917] Cancer Res. 2008 Oct 15;68(20):8195-200 [18922890] Biochem Biophys Res Commun. 2008 Dec 5;377(1):136-40 [18834857] J Clin Endocrinol Metab. 2008 Nov;93(11):4175-82 [18987277] Curr Opin Oncol. 2009 Jan;21(1):11-7 [19125013] Sci Signal. 2009 Jan 6;2(52):pe1 [19126861] Cancer Res. 2010 Nov 1;70(21):8822-31 [20978205] Cytopathology. 2010 Apr;21(2):75-85 [21054821] Cancer Lett. 2011 Jan 1;300(1):10-9 [20965651] J Clin Endocrinol Metab. 2010 Dec;95(12):5296-304 [20826580] Surgery. 2010 Dec;148(6):1170-6; discussion 1176-7 [21134548] Surgery. 2010 Dec;148(6):1294-9; discussion 1299-301 [21134564] Surgery. 2010 Dec;148(6):1313-5 [21134567] Cancer Sci. 2011 Jan;102(1):9-17 [20735434] Thyroid. 2011 Feb;21(2):111-8 [21275764] Clin Chem Lab Med. 2011 Feb;49(2):325-9 [21175381] Arch Pathol Lab Med. 2009 May;133(5):787-90 [19415954] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1245/s10434-011-1766-4 ER - TY - JOUR T1 - Liver toxicity and carcinogenicity in F344/N rats and B6C3F1 mice exposed to Kava Kava. AN - 898166827; 21871523 AB - Kava Kava is an herbal supplement used as an alternative to antianxiety drugs. Although some reports suggest an association of Kava Kava with hepatotoxicity , it continues to be used in the United States due to lack of toxicity characterization. In these studies F344/N rats and B6C3F1 mice were administered Kava Kava extract orally by gavage in corn oil for two weeks, thirteen weeks or two years. Results from prechronic studies administered Kava Kava at 0.125 to 2g/kg body weight revealed dose-related increases in liver weights and incidences of hepatocellular hypertrophy. In the chronic studies, there were dose-related increases in the incidences of hepatocellular hypertrophy in rats and mice administered Kava Kava for up to 1g/kg body weight. This was accompanied by significant increases in incidences of centrilobular fatty change. There was no treatment- related increase in carcinogenic activity in the livers of male or female rats in the chronic studies. Male mice showed a significant dose-related increase in the incidence of hepatoblastomas. In female mice, there was a significant increase in the combined incidence of hepatocellular adenoma and carcinoma in the low and mid dose groups but not in the high dose group. These findings were accompanied by several nonneoplastic hepatic lesions. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Behl, Mamta AU - Nyska, Abraham AU - Chhabra, Rajendra S AU - Travlos, Gregory S AU - Fomby, Laurene M AU - Sparrow, Barney R AU - Hejtmancik, Milton R AU - Chan, Po C AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 2820 EP - 2829 VL - 49 IS - 11 KW - Index Medicus KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Liver -- pathology KW - Drug Administration Schedule KW - Sex Characteristics KW - Dose-Response Relationship, Drug KW - Carcinogenicity Tests KW - Mice KW - Male KW - Female KW - Chemical and Drug Induced Liver Injury -- pathology KW - Kava -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/898166827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Liver+toxicity+and+carcinogenicity+in+F344%2FN+rats+and+B6C3F1+mice+exposed+to+Kava+Kava.&rft.au=Behl%2C+Mamta%3BNyska%2C+Abraham%3BChhabra%2C+Rajendra+S%3BTravlos%2C+Gregory+S%3BFomby%2C+Laurene+M%3BSparrow%2C+Barney+R%3BHejtmancik%2C+Milton+R%3BChan%2C+Po+C&rft.aulast=Behl&rft.aufirst=Mamta&rft.date=2011-11-01&rft.volume=49&rft.issue=11&rft.spage=2820&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2011.07.067 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-02-13 N1 - Date created - 2011-10-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cochrane Database Syst Rev. 2002;(2):CD003383 [12076477] Case Manager. 2002 Jul-Aug;13(4):26-8 [12131903] J Altern Complement Med. 2002 Jun;8(3):237-63 [12165183] Life Sci. 2002 Apr 19;70(22):2581-97 [12269386] Drug Metab Dispos. 2002 Nov;30(11):1153-7 [12386118] Lancet. 2002 Oct 26;360(9342):1336 [12414243] MMW Fortschr Med. 2002 Oct 10;144(41):40 [12474360] Planta Med. 2002 Dec;68(12):1055-8 [12494328] Cochrane Database Syst Rev. 2003;(1):CD003383 [12535473] J Clin Psychiatry. 2003 Feb;64(2):216-8 [12633134] Drug Metab Dispos. 2003 May;31(5):533-9 [12695340] Med J Aust. 2003 May 5;178(9):442-3 [12720510] J Toxicol Clin Toxicol. 2003;41(2):109-13 [12733846] Phytomedicine. 2003;10 Suppl 4:68-73 [12807347] J Hepatol. 2003 Jul;39(1):62-7 [12821045] Phytomedicine. 2003;10(5):440-6 [12834011] Planta Med. 2003 Jun;69(6):496-9 [12865965] Eur J Gastroenterol Hepatol. 2003 Sep;15(9):1033-6 [12923378] Phytochemistry. 2003 Oct;64(3):673-9 [13679089] CMAJ. 2003 Nov 25;169(11):1158-9 [14638649] CMAJ. 2003 Nov 25;169(11):1163-4 [14638650] Integr Cancer Ther. 2002 Sep;1(3):287-93; discussion 293 [14667286] J Toxicol Clin Toxicol. 2003;41(6):821-9 [14677792] Planta Med. 2003 Nov;69(11):971-2 [14735431] Med J Aust. 2004 Feb 16;180(4):198-9; author reply 199 [14960147] Planta Med. 2004 Mar;70(3):193-6 [15114493] Toxicol Pathol. 2004 Jul-Aug;32(4):393-401 [15307212] Biometrics. 1971 Mar;27(1):103-17 [5547548] Farmaco Prat. 1971 Nov;26(11):692-720 [5157783] Biometrics. 1977 Jun;33(2):386-9 [884197] Biometrics. 1986 Mar;42(1):183-6 [3719054] Biometrics. 1988 Jun;44(2):417-31 [3390507] Fundam Appl Toxicol. 1989 May;12(4):731-7 [2744275] Clin Exp Pharmacol Physiol. 1990 Jul;17(7):495-507 [2401103] Clin Exp Pharmacol Physiol. 1990 Jul;17(7):509-14 [2401104] Int J Biochem. 1990;22(9):997-1004 [1980896] J Ethnopharmacol. 1992 Aug;37(1):13-45 [1453702] J Am Acad Dermatol. 1994 Jul;31(1):89-97 [8021378] Toxicol Pathol. 1997 May-Jun;25(3):256-63 [9210256] Toxicol Sci. 1998 Mar;42(1):1-12 [9538042] Eur J Clin Pharmacol. 1998 Jul;54(5):431-5 [9754989] Pharmacogenomics J. 2005;5(1):6-13 [15492763] Planta Med. 2005 Feb;71(2):142-6 [15729622] Drugs. 2005;65(9):1239-82 [15916450] Geriatrics. 2005 Sep;60(9):24-5 [16153141] Drug Metab Dispos. 2005 Oct;33(10):1555-63 [16033948] Phytomedicine. 2006 Feb;13(3):205-8 [16428031] Exp Toxicol Pathol. 2007 Jan;58(4):223-36 [17059882] Altern Ther Health Med. 2007 Mar-Apr;13(2):22-9 [17405675] Toxicol Sci. 2007 May;97(1):214-21 [17329236] J Food Sci. 2007 Mar;72(2):C120-5 [17995826] Food Chem Toxicol. 2008 Jan;46(1):168-74 [17822821] World J Gastroenterol. 2008 Jan 28;14(4):541-6 [18203285] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008 Jan-Mar;26(1):89-112 [18322868] Eur J Gastroenterol Hepatol. 2008 Dec;20(12):1182-93 [18989142] Food Chem Toxicol. 2009 Feb;47(2):433-42 [19100306] Int J Toxicol. 2009 Nov-Dec;28(6 Suppl):175S-88S [19966149] Food Chem Toxicol. 2010 Feb;48(2):686-96 [19948201] Natl Toxicol Program Tech Rep Ser. 2012 Mar;(571):1-186 [22441424] J Clin Psychopharmacol. 2000 Feb;20(1):84-9 [10653213] J Clin Pharm Ther. 2000 Jun;25(3):197-220 [10886465] BMJ. 2001 Jan 20;322(7279):139 [11159570] Ann Intern Med. 2001 Jul 3;135(1):68-9 [11434754] Dtsch Med Wochenschr. 2001 Sep 7;126(36):970-2 [11544547] AWHONN Lifelines. 2002 Feb-Mar;6(1):13-5 [11971236] J Am Acad Child Adolesc Psychiatry. 2002 Jun;41(6):631-2 [12049436] Gastroenterol Hepatol. 2002 Jun-Jul;25(6):434-5 [12069710] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fct.2011.07.067 ER - TY - JOUR T1 - A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3. AN - 897812602; 21824976 AB - Genome-wide and candidate-gene association studies of bladder cancer have identified 10 susceptibility loci thus far. We conducted a meta-analysis of two previously published genome-wide scans (4501 cases and 6076 controls of European background) and followed up the most significant association signals [17 single nucleotide polymorphisms (SNPs) in 10 genomic regions] in 1382 cases and 2201 controls from four studies. A combined analysis adjusted for study center, age, sex, and smoking status identified a novel susceptibility locus that mapped to a region of 18q12.3, marked by rs7238033 (P = 8.7 × 10(-9); allelic odds ratio 1.20 with 95% CI: 1.13-1.28) and two highly correlated SNPs, rs10775480/rs10853535 (r(2)= 1.00; P = 8.9 × 10(-9); allelic odds ratio 1.16 with 95% CI: 1.10-1.22). The signal localizes to the solute carrier family 14 member 1 gene, SLC14A1, a urea transporter that regulates cellular osmotic pressure. In the kidney, SLC14A1 regulates urine volume and concentration whereas in erythrocytes it determines the Kidd blood groups. Our findings suggest that genetic variation in SLC14A1 could provide new etiological insights into bladder carcinogenesis. JF - Human molecular genetics AU - Garcia-Closas, Montserrat AU - Ye, Yuanqing AU - Rothman, Nathaniel AU - Figueroa, Jonine D AU - Malats, Núria AU - Dinney, Colin P AU - Chatterjee, Nilanjan AU - Prokunina-Olsson, Ludmila AU - Wang, Zhaoming AU - Lin, Jie AU - Real, Francisco X AU - Jacobs, Kevin B AU - Baris, Dalsu AU - Thun, Michael AU - De Vivo, Immaculata AU - Albanes, Demetrius AU - Purdue, Mark P AU - Kogevinas, Manolis AU - Kamat, Ashish M AU - Lerner, Seth P AU - Grossman, H Barton AU - Gu, Jian AU - Pu, Xia AU - Hutchinson, Amy AU - Fu, Yi-Ping AU - Burdett, Laurie AU - Yeager, Meredith AU - Tang, Wei AU - Tardón, Adonina AU - Serra, Consol AU - Carrato, Alfredo AU - García-Closas, Reina AU - Lloreta, Josep AU - Johnson, Alison AU - Schwenn, Molly AU - Karagas, Margaret R AU - Schned, Alan AU - Andriole, Gerald AU - Grubb, Robert AU - Black, Amanda AU - Jacobs, Eric J AU - Diver, W Ryan AU - Gapstur, Susan M AU - Weinstein, Stephanie J AU - Virtamo, Jarmo AU - Hunter, David J AU - Caporaso, Neil AU - Landi, Maria Teresa AU - Fraumeni, Joseph F AU - Silverman, Debra T AU - Chanock, Stephen J AU - Wu, Xifeng AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. montse.garciaclosas@icr.ac.uk Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 4282 EP - 4289 VL - 20 IS - 21 KW - Membrane Transport Proteins KW - 0 KW - urea transporter KW - Index Medicus KW - Risk Factors KW - Humans KW - Linkage Disequilibrium -- genetics KW - Polymorphism, Single Nucleotide -- genetics KW - Urinary Bladder Neoplasms -- genetics KW - Urinary Bladder Neoplasms -- mortality KW - Genetic Loci -- genetics KW - Chromosomes, Human, Pair 18 -- genetics KW - Genetic Predisposition to Disease KW - Membrane Transport Proteins -- genetics KW - Genome-Wide Association Study UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/897812602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+molecular+genetics&rft.atitle=A+genome-wide+association+study+of+bladder+cancer+identifies+a+new+susceptibility+locus+within+SLC14A1%2C+a+urea+transporter+gene+on+chromosome+18q12.3.&rft.au=Garcia-Closas%2C+Montserrat%3BYe%2C+Yuanqing%3BRothman%2C+Nathaniel%3BFigueroa%2C+Jonine+D%3BMalats%2C+N%C3%BAria%3BDinney%2C+Colin+P%3BChatterjee%2C+Nilanjan%3BProkunina-Olsson%2C+Ludmila%3BWang%2C+Zhaoming%3BLin%2C+Jie%3BReal%2C+Francisco+X%3BJacobs%2C+Kevin+B%3BBaris%2C+Dalsu%3BThun%2C+Michael%3BDe+Vivo%2C+Immaculata%3BAlbanes%2C+Demetrius%3BPurdue%2C+Mark+P%3BKogevinas%2C+Manolis%3BKamat%2C+Ashish+M%3BLerner%2C+Seth+P%3BGrossman%2C+H+Barton%3BGu%2C+Jian%3BPu%2C+Xia%3BHutchinson%2C+Amy%3BFu%2C+Yi-Ping%3BBurdett%2C+Laurie%3BYeager%2C+Meredith%3BTang%2C+Wei%3BTard%C3%B3n%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarc%C3%ADa-Closas%2C+Reina%3BLloreta%2C+Josep%3BJohnson%2C+Alison%3BSchwenn%2C+Molly%3BKaragas%2C+Margaret+R%3BSchned%2C+Alan%3BAndriole%2C+Gerald%3BGrubb%2C+Robert%3BBlack%2C+Amanda%3BJacobs%2C+Eric+J%3BDiver%2C+W+Ryan%3BGapstur%2C+Susan+M%3BWeinstein%2C+Stephanie+J%3BVirtamo%2C+Jarmo%3BHunter%2C+David+J%3BCaporaso%2C+Neil%3BLandi%2C+Maria+Teresa%3BFraumeni%2C+Joseph+F%3BSilverman%2C+Debra+T%3BChanock%2C+Stephen+J%3BWu%2C+Xifeng&rft.aulast=Garcia-Closas&rft.aufirst=Montserrat&rft.date=2011-11-01&rft.volume=20&rft.issue=21&rft.spage=4282&rft.isbn=&rft.btitle=&rft.title=Human+molecular+genetics&rft.issn=1460-2083&rft_id=info:doi/10.1093%2Fhmg%2Fddr342 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-31 N1 - Date created - 2011-10-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genetics. 2000 Jun;155(2):945-59 [10835412] Transfusion. 2011 Feb;51(2):380-92 [21309779] Pflugers Arch. 2004 Feb;447(5):603-9 [12856182] Nat Genet. 2004 Apr;36(4):388-93 [15052270] Genetics. 2004 Aug;167(4):2067-81 [15342541] Environ Health Perspect. 1979 Apr;29:71-9 [510245] Transfusion. 1982 Jan-Feb;22(1):70-1 [7064211] Am J Physiol. 1991 Apr;260(4 Pt 1):C778-83 [1902060] J Am Soc Nephrol. 1992 Jun;2(12):1689-96 [1498276] J Natl Cancer Inst. 1993 Jul 21;85(14):1159-64 [8320745] Epidemiology. 1994 Mar;5(2):218-25 [8172997] Lancet. 2005 Aug 20-26;366(9486):649-59 [16112301] Bioinformatics. 2006 Dec 15;22(24):3061-6 [17060358] Int J Epidemiol. 2007 Feb;36(1):23-8 [17510073] Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1595-600 [17684133] Am J Hum Genet. 2007 Sep;81(3):559-75 [17701901] Biostatistics. 2008 Oct;9(4):593-600 [18441336] Hum Mol Genet. 2008 Oct 15;17(R2):R122-8 [18852200] Nat Genet. 2008 Nov;40(11):1307-12 [18794855] Nat Genet. 2009 Feb;41(2):221-7 [19151717] Nat Genet. 2009 Sep;41(9):991-5 [19648920] Eur Urol. 2010 Feb;57(2):283-92 [19692168] Nat Genet. 2010 May;42(5):415-9 [20348956] Nat Genet. 2010 Jul;42(7):570-5 [20562874] Urol Oncol. 2010 Jul-Aug;28(4):409-28 [20610279] Nat Genet. 2010 Nov;42(11):978-84 [20972438] J Biol Chem. 2002 Mar 22;277(12):10633-7 [11792714] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/hmg/ddr342 ER - TY - JOUR T1 - A pilot safety trial investigating a vector-based vaccine targeting carcinoembryonic antigen in combination with radiotherapy in patients with gastrointestinal malignancies metastatic to the liver. AN - 896826905; 21871012 AB - Previous studies have demonstrated the ability of non-lethal doses of radiation to alter the phenotype of tumor cells to facilitate immune mediated killing. This pilot study evaluated the tolerability of a vector-based vaccine targeting carcinoembryonic antigen (CEA) in combination with radiation therapy in patients with gastrointestinal malignancies metastatic to the liver. Patients enrolled had progressive CEA(+) tumors with metastatic liver lesions. Patients had received a median of three previous chemotherapy regimens, with a median of 2 months since their last chemotherapy regimen. Only 58% had metastatic disease limited to the liver. Vaccination commenced day 1 with biweekly boosters and split-course radiation (total 32 Gy) starting on day 21. Blood was collected at baseline and day 91 for immunological analysis. A total of 12 patients were enrolled. There were no grade 3 or greater toxicities or grade 2 or greater hepatic toxicities. Median time on-study was 3 months, with the longest time on treatment being 5 months (n = 2). Immunological analysis was limited to two patients; neither showed an increase above baseline in CEA-specific T cells post-therapy. CEA/TRICOM vaccination in combination with low-dose radiation therapy is safe. There was limited evidence of activity in this patient population. JF - Expert opinion on biological therapy AU - Gulley, James L AU - Madan, Ravi A AU - Tsang, Kwong-Yok AU - Arlen, Philip M AU - Camphausen, Kevin AU - Mohebtash, Mahsa AU - Kamrava, Mitchell AU - Schlom, Jeffrey AU - Citrin, Deborah AD - National Cancer Institute, National Institutes of Health, Center for Cancer Research, Laboratory of Tumor Immunology and Biology, 10 Center Dr, 8B09 MSC 1750, Bethesda, MD 20892, USA. gulleyj@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 1409 EP - 1418 VL - 11 IS - 11 KW - Cancer Vaccines KW - 0 KW - Carcinoembryonic Antigen KW - Vaccines, Synthetic KW - Index Medicus KW - United States KW - Radiation Dosage KW - Radiotherapy, Adjuvant KW - National Cancer Institute (U.S.) KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Pilot Projects KW - Middle Aged KW - Vaccines, Synthetic -- therapeutic use KW - Time Factors KW - Male KW - Liver Neoplasms -- radiotherapy KW - Rectal Neoplasms -- therapy KW - Colonic Neoplasms -- genetics KW - Cancer Vaccines -- adverse effects KW - Carcinoembryonic Antigen -- immunology KW - Fowlpox virus -- genetics KW - Cancer Vaccines -- therapeutic use KW - Rectal Neoplasms -- pathology KW - Liver Neoplasms -- secondary KW - Colonic Neoplasms -- immunology KW - Rectal Neoplasms -- genetics KW - Rectal Neoplasms -- immunology KW - Colonic Neoplasms -- radiotherapy KW - Rectal Neoplasms -- radiotherapy KW - Liver Neoplasms -- therapy KW - Colonic Neoplasms -- therapy KW - Genetic Vectors KW - Colonic Neoplasms -- pathology KW - Carcinoembryonic Antigen -- genetics KW - Radiotherapy, Conformal -- adverse effects KW - Liver Neoplasms -- immunology KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896826905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+biological+therapy&rft.atitle=A+pilot+safety+trial+investigating+a+vector-based+vaccine+targeting+carcinoembryonic+antigen+in+combination+with+radiotherapy+in+patients+with+gastrointestinal+malignancies+metastatic+to+the+liver.&rft.au=Gulley%2C+James+L%3BMadan%2C+Ravi+A%3BTsang%2C+Kwong-Yok%3BArlen%2C+Philip+M%3BCamphausen%2C+Kevin%3BMohebtash%2C+Mahsa%3BKamrava%2C+Mitchell%3BSchlom%2C+Jeffrey%3BCitrin%2C+Deborah&rft.aulast=Gulley&rft.aufirst=James&rft.date=2011-11-01&rft.volume=11&rft.issue=11&rft.spage=1409&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+biological+therapy&rft.issn=1744-7682&rft_id=info:doi/10.1517%2F14712598.2011.615741 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-02-01 N1 - Date created - 2011-10-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cancer Res. 1999 Nov 15;59(22):5800-7 [10582702] Semin Radiat Oncol. 2005 Oct;15(4):279-83 [16183482] Int J Cancer. 2000 Sep 1;87(5):680-7 [10925362] J Clin Oncol. 2000 Dec 1;18(23):3964-73 [11099326] Hum Pathol. 2000 Nov;31(11):1357-62 [11112209] Clin Cancer Res. 2001 May;7(5):1181-91 [11350882] Cancer Res. 2001 Jun 1;61(11):4497-505 [11389081] J Immunol. 2001 Aug 1;167(3):1137-40 [11466326] Br J Cancer. 2002 Feb 1;86(3):417-23 [11875709] Cancer Immunol Immunother. 2006 Mar;55(3):268-76 [16034561] Expert Opin Pharmacother. 2006 Aug;7(11):1475-86 [16859431] Curr Cancer Drug Targets. 2007 Feb;7(1):31-40 [17305476] Clin Cancer Res. 2007 Nov 1;13(21):6247-51 [17975134] Clin Cancer Res. 2008 Feb 15;14(4):1032-40 [18281535] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Clin Cancer Res. 2008 May 15;14(10):3060-9 [18483372] Clin Cancer Res. 2008 Jul 15;14(14):4526-31 [18628467] Clin Cancer Res. 2008 Aug 15;14(16):5284-91 [18698048] Oncology (Williston Park). 2008 Aug;22(9):1064-70; discussion 1075, 1080-1, 1084 [18777956] Curr Opin Mol Ther. 2009 Feb;11(1):37-42 [19169958] J Clin Oncol. 2009 Apr 1;27(10):1572-8 [19255321] Cancer Immunol Immunother. 2010 May;59(5):663-74 [19890632] Hum Gene Ther. 2009 Feb;20(2):125-36 [18937552] J Natl Cancer Inst. 2010 Sep 22;102(18):1388-97 [20826737] Neoplasia. 2002 Mar-Apr;4(2):151-63 [11896570] J Immunol. 2002 May 1;168(9):4272-6 [11970966] Anticancer Res. 2002 Jul-Aug;22(4):2437-42 [12174940] Clin Cancer Res. 2002 Oct;8(10):3219-25 [12374692] Cancer Res. 2002 Oct 15;62(20):5770-7 [12384537] Cancer Res. 2002 Dec 1;62(23):6944-51 [12460911] Vaccine. 2003 Dec 12;22(2):224-36 [14615150] Eur J Immunol. 2004 Feb;34(2):336-44 [14768038] Expert Opin Biol Ther. 2004 Apr;4(4):575-88 [15102606] Cancer Res. 2004 Jun 15;64(12):4328-37 [15205348] J Nucl Med. 1987 Apr;28(4):495-504 [3572535] Cell. 1989 Apr 21;57(2):327-34 [2702691] Arch Surg. 1990 Mar;125(3):300-4 [2407225] Int J Cancer. 1993 Apr 1;53(6):892-7 [8386136] Ann N Y Acad Sci. 1993 Aug 12;690:370-3 [8368759] J Natl Cancer Inst. 1995 Jul 5;87(13):982-90 [7629885] Vaccine. 1997 Apr-May;15(6-7):759-68 [9178479] Cancer Res. 1997 Oct 15;57(20):4570-7 [9377571] Cancer Res. 1999 Feb 1;59(3):676-83 [9973217] Cancer Res. 2004 Nov 1;64(21):7985-94 [15520206] J Clin Oncol. 2005 Feb 1;23(4):720-31 [15613691] Clin Cancer Res. 2005 May 1;11(9):3353-62 [15867235] J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1517/14712598.2011.615741 ER - TY - JOUR T1 - Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury. AN - 896526626; 21884784 AB - Cisplatin is a commonly used chemotherapeutic drug, the clinical use of which is limited by the development of dose-dependent nephrotoxicity. Enhanced inflammatory response, oxidative stress, and cell death have been implicated in the development of cisplatin-induced nephropathy; however, the precise mechanisms are elusive. Overactivation of the nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) by oxidative DNA damage under various pathological conditions promotes cell death and up-regulation of key proinflammatory pathways. In this study, using a well-established model of nephropathy, we have explored the role of PARP-1 in cisplatin-induced kidney injury. Genetic deletion or pharmacological inhibition of PARP-1 markedly attenuated the cisplatin-induced histopathological damage, impaired renal function (elevated serum BUN and creatinine levels), and enhanced inflammatory response (leukocyte infiltration; TNF-α, IL-1β, F4/80, adhesion molecules ICAM-1/VCAM-1 expression) and consequent oxidative/nitrative stress (4-HNE, 8-OHdG, and nitrotyrosine content; NOX2/NOX4 expression). PARP inhibition also facilitated the cisplatin-induced death of cancer cells. Thus, PARP activation plays an important role in cisplatin-induced kidney injury, and its pharmacological inhibition may represent a promising approach to preventing the cisplatin-induced nephropathy. This is particularly exciting because several PARP inhibitors alone or in combination with DNA-damaging anticancer agents show considerable promise in clinical trials for treatment of various malignancies (e.g., triple-negative breast cancer). Published by Elsevier Inc. JF - Free radical biology & medicine AU - Mukhopadhyay, Partha AU - Horváth, Béla AU - Kechrid, Malek AU - Tanchian, Galin AU - Rajesh, Mohanraj AU - Naura, Amarjit S AU - Boulares, A Hamid AU - Pacher, Pál AD - Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 1774 EP - 1788 VL - 51 IS - 9 KW - Parp1 protein, mouse KW - EC 2.4.2.30 KW - Poly (ADP-Ribose) Polymerase-1 KW - Poly(ADP-ribose) Polymerases KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Mice KW - Male KW - Mice, Knockout KW - Cisplatin -- toxicity KW - Acute Kidney Injury -- chemically induced KW - Inflammation -- chemically induced KW - Inflammation -- metabolism KW - Poly(ADP-ribose) Polymerases -- metabolism KW - Poly(ADP-ribose) Polymerases -- deficiency KW - Acute Kidney Injury -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896526626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Poly%28ADP-ribose%29+polymerase-1+is+a+key+mediator+of+cisplatin-induced+kidney+inflammation+and+injury.&rft.au=Mukhopadhyay%2C+Partha%3BHorv%C3%A1th%2C+B%C3%A9la%3BKechrid%2C+Malek%3BTanchian%2C+Galin%3BRajesh%2C+Mohanraj%3BNaura%2C+Amarjit+S%3BBoulares%2C+A+Hamid%3BPacher%2C+P%C3%A1l&rft.aulast=Mukhopadhyay&rft.aufirst=Partha&rft.date=2011-11-01&rft.volume=51&rft.issue=9&rft.spage=1774&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=1873-4596&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2011.08.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-27 N1 - Date created - 2011-10-05 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Am Coll Cardiol. 2010 Dec 14;56(25):2115-25 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Nat Rev Drug Discov. 2005 Apr;4(4):307-20 [15789122] Nat Rev Drug Discov. 2005 May;4(5):421-40 [15864271] Pharmacol Res. 2005 Jul;52(1):60-71 [15911334] Pharmacol Res. 2005 Jul;52(1):109-18 [15911339] Curr Vasc Pharmacol. 2005 Jul;3(3):293-9 [16026325] Int J Mol Med. 2006 Feb;17(2):369-75 [16391839] J Am Soc Nephrol. 2006 Mar;17(3):765-74 [16481417] Nephrol Dial Transplant. 2006 Aug;21(8):2085-95 [16705027] Biochem Biophys Res Commun. 2006 Nov 17;350(2):352-7 [17007818] Biochem Biophys Res Commun. 2006 Dec 1;350(4):1056-62 [17046715] Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18314-9 [17116881] Physiol Rev. 2007 Jan;87(1):315-424 [17237348] Circulation. 2007 May 8;115(18):2442-50 [17438151] Nat Rev Drug Discov. 2007 Aug;6(8):662-80 [17667957] Nat Protoc. 2007;2(9):2295-301 [17853886] Eur J Cancer. 2007 Sep;43(14):2124-33 [17714938] Curr Opin Investig Drugs. 2007 Dec;8(12):1051-6 [18058575] Free Radic Biol Med. 2008 Mar 15;44(6):972-81 [17976390] Kidney Int. 2008 May;73(9):994-1007 [18272962] J Am Soc Nephrol. 2008 May;19(5):923-32 [18256356] Int J Mol Med. 2008 Jul;22(1):113-8 [18575783] Arch Biochem Biophys. 2008 Sep 15;477(2):183-95 [18602883] J Pharmacol Exp Ther. 2009 Mar;328(3):708-14 [19074681] Front Biosci (Landmark Ed). 2009;14:1116-28 [19273119] Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1778-90 [19098320] Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1466-83 [19286953] J Clin Invest. 2009 May;119(5):1275-85 [19349686] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Apr;27(2):120-39 [19412858] J Am Soc Nephrol. 2009 Jun;20(6):1323-32 [19423693] Free Radic Biol Med. 2009 Jul 1;47(1):13-26 [19362586] N Engl J Med. 2009 Jul 9;361(2):123-34 [19553641] Kidney Int. 2009 Aug;76(3):277-85 [19436334] J Am Soc Nephrol. 2010 Jan;21(1):53-63 [19875815] Biochem Pharmacol. 2010 Apr 1;79(7):1007-14 [19945439] Free Radic Biol Med. 2010 Feb 1;48(3):457-67 [19969072] Nat Rev Cancer. 2010 Apr;10(4):293-301 [20200537] J Clin Oncol. 2010 May 20;28(15):2512-9 [20406929] Br J Pharmacol. 2010 Jun;160(3):657-68 [20590569] Lancet. 2010 Jul 24;376(9737):235-44 [20609467] Lancet. 2010 Jul 24;376(9737):245-51 [20609468] Biochim Biophys Acta. 2010 Nov;1802(11):1020-7 [20621183] J Am Soc Nephrol. 2010 Oct;21(10):1702-12 [20705711] J Immunol. 2010 Oct 15;185(8):4904-11 [20844196] Cancer Res. 2010 Oct 15;70(20):7970-80 [20798217] Int J Cancer. 2011 Jan 15;128(2):251-65 [20853319] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2011.08.006 ER - TY - JOUR T1 - Biomarkers of Oxidative Stress Study IV: ozone exposure of rats and its effect on antioxidants in plasma and bronchoalveolar lavage fluid. AN - 896524736; 21824516 AB - The objective of this study was to determine whether acutely exposing rats to ozone would result in the loss of antioxidants from plasma and bronchoalveolar lavage fluid (BALF). Additional goals were to compare analyses of the same antioxidant concentration between different laboratories, to investigate which methods have the sensitivity to detect decreased levels of antioxidants, and to identify a reliable measure of oxidative stress in ozone-exposed rats. Male Fisher rats were exposed to either 2.0 or 5.0 ppm ozone inhalation for 2h. Blood plasma and BALF samples were collected 2, 7, and 16 h after the exposure. It was found that ascorbic acid in plasma collected from rats after the higher dose of ozone was lower at 2h, but not later. BALF concentrations of ascorbic acid were decreased at both 2 and 7h postexposure. Tocopherols (α, δ, γ), 5-nitro-γ-tocopherol, tocol, glutathione (GSH/GSSG), and cysteine (Cys/CySS) were not decreased, regardless of the dose or postexposure time point used for sample collection. Uric acid was significantly increased by the low dose at 2h and the high dose at the 7h point, probably because of the accumulation of blood plasma in the lung from ozone-increased alveolar capillary permeability. We conclude that measurements of antioxidants in plasma are not sensitive biomarkers for oxidative damage induced by ozone and are not a useful choice for the assessment of oxidative damage by ozone in vivo. Published by Elsevier Inc. JF - Free radical biology & medicine AU - Kadiiska, Maria B AU - Hatch, Gary E AU - Nyska, Abraham AU - Jones, Dean P AU - Hensley, Kenneth AU - Stocker, Roland AU - George, Magdalene M AU - Van Thiel, David H AU - Stadler, Krisztian AU - Barrett, J Carl AU - Mason, Ronald P AD - Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Kadiiska@niehs.nih.gov Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 1636 EP - 1642 VL - 51 IS - 9 KW - Antioxidants KW - 0 KW - Biomarkers KW - Uric Acid KW - 268B43MJ25 KW - Ozone KW - 66H7ZZK23N KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Dose-Response Relationship, Drug KW - Ascorbic Acid -- blood KW - Administration, Inhalation KW - Time Factors KW - Biomarkers -- blood KW - Uric Acid -- blood KW - Male KW - Antioxidants -- analysis KW - Antioxidants -- metabolism KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Ozone -- pharmacology KW - Oxidative Stress -- drug effects KW - Ozone -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896524736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Biomarkers+of+Oxidative+Stress+Study+IV%3A+ozone+exposure+of+rats+and+its+effect+on+antioxidants+in+plasma+and+bronchoalveolar+lavage+fluid.&rft.au=Kadiiska%2C+Maria+B%3BHatch%2C+Gary+E%3BNyska%2C+Abraham%3BJones%2C+Dean+P%3BHensley%2C+Kenneth%3BStocker%2C+Roland%3BGeorge%2C+Magdalene+M%3BVan+Thiel%2C+David+H%3BStadler%2C+Krisztian%3BBarrett%2C+J+Carl%3BMason%2C+Ronald+P&rft.aulast=Kadiiska&rft.aufirst=Maria&rft.date=2011-11-01&rft.volume=51&rft.issue=9&rft.spage=1636&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=1873-4596&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2011.07.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-27 N1 - Date created - 2011-10-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am Rev Respir Dis. 1989 Feb;139(2):407-15 [2913889] Proc Natl Acad Sci U S A. 1988 Dec;85(24):9748-52 [3200852] Free Radic Res Commun. 1990;9(1):1-32 [2159941] J Lipid Res. 1990 Apr;31(4):675-85 [2351872] J Lipid Res. 1990 Apr;31(4):687-94 [2351873] Am J Physiol. 1990 Jun;258(6 Pt 1):L313-20 [2360644] Free Radic Biol Med. 1990;9(3):245-65 [2272533] Exp Lung Res. 1991 May-Jun;17(3):547-58 [1860453] FEBS Lett. 1992 Feb 24;298(2-3):269-72 [1544461] Toxicol Appl Pharmacol. 1992 May;114(1):41-6 [1316646] Toxicol Appl Pharmacol. 1992 Jun;114(2):268-76 [1609419] Biochem J. 1992 Dec 1;288 ( Pt 2):341-4 [1463440] Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):45-9 [8419943] Am Rev Respir Dis. 1993 Mar;147(3):753-60 [8442612] Environ Health Perspect. 1993 Dec;101 Suppl 4:219-24 [8206036] Am J Physiol. 1994 Jun;266(6 Pt 1):L612-9 [8023949] Free Radic Biol Med. 1994 Nov;17(5):451-65 [7835752] Toxicol Lett. 1995 Dec;82-83:287-93 [8597067] Toxicol Lett. 1995 Dec;82-83:295-300 [8597068] Toxicol Appl Pharmacol. 1996 Sep;140(1):1-12 [8806864] Exp Lung Res. 1996 Jul-Aug;22(4):435-48 [8872087] Am J Physiol. 1996 Oct;271(4 Pt 1):L555-65 [8897902] Free Radic Res. 1996 Dec;25(6):475-88 [8951421] Toxicol Appl Pharmacol. 1996 Dec;141(2):416-24 [8975766] Am J Respir Cell Mol Biol. 1997 Dec;17(6):740-7 [9409561] J Inflamm. 1998;48(2):56-66 [9656142] Clin Chim Acta. 1998 Jul 28;275(2):175-84 [9721075] J Toxicol Environ Health B Crit Rev. 1999 Jan-Mar;2(1):31-86 [10081525] FASEB J. 1999 Jun;13(9):995-1006 [10336882] Eur Respir J. 1999 Jun;13(6):1429-38 [10445623] Free Radic Biol Med. 2005 Feb 15;38(4):515-26 [15649654] Biochem Pharmacol. 2005 Aug 1;70(3):343-54 [15963955] Methods Enzymol. 2005;396:171-82 [16291232] Clin Chem. 2006 Apr;52(4):601-23 [16484333] Proc Am Thorac Soc. 2007 Jul;4(3):240-6 [17607006] Am J Respir Cell Mol Biol. 2009 Jan;40(1):90-8 [18664641] Free Radic Biol Med. 2009 Mar 1;46(5):531-42 [19111608] Free Radic Biol Med. 2009 Nov 15;47(10):1329-38 [19715755] Mol Nutr Food Res. 2010 May;54(5):601-15 [20169582] Free Radic Biol Med. 2000 Mar 15;28(6):838-45 [10802213] Free Radic Biol Med. 2001 Mar 1;30(5):456-62 [11182517] Mutat Res. 2001 Apr 18;475(1-2):29-35 [11295151] Free Radic Biol Med. 2004 Mar 1;36(5):673-81 [14980710] Am J Respir Crit Care Med. 2004 Mar 15;169(6):726-32 [14701711] Proc Natl Acad Sci U S A. 1981 Nov;78(11):6858-62 [6947260] Am Rev Respir Dis. 1983 Jun;127(6):686-90 [6859651] Am Rev Respir Dis. 1984 Aug;130(2):214-9 [6465675] J Free Radic Biol Med. 1985;1(2):117-24 [3836238] Am J Clin Nutr. 1987 Apr;45(4):693-703 [3565296] Arch Biochem Biophys. 1987 Nov 15;259(1):224-5 [3688884] Anal Biochem. 1987 Nov 1;166(2):424-30 [3434782] Am Rev Respir Dis. 1989 Aug;140(2):493-501 [2527482] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2011.07.013 ER - TY - JOUR T1 - Preserved learning and memory following 5-fluorouracil and cyclophosphamide treatment in rats. AN - 895854861; 21875615 AB - Some patients experience enduring cognitive impairment after cancer treatment, a condition termed "chemofog". Animal models allow assessment of chemotherapy effects on learning and memory per se, independent of changes due to cancer itself or associated health consequences such as depression. The present study examined the long-term learning and memory effects of a chemotherapy cocktail used widely in the treatment of breast cancer, consisting of 5-fluorouracil (5FU) and cyclophosphamide (CYP). Eighty 5-month old male F344 rats received contextual and cued fear conditioning before treatment with saline, or a low or high dose drug cocktail (50mg/kg CYP and 75 mg/kg 5FU, or 75 mg/kg CYP and 120 mg/kg 5FU, i.p., respectively) every 30 days for 2 months. After a 2-month, no-drug recovery, both long-term retention and new task acquisition in the water maze and 14-unit T-maze were assessed. Neither dose of the CYP/5FU cocktail impaired retrograde fear memory despite marked toxicity documented by enduring weight loss and 50% mortality at the higher dose. Acquisition in the water maze and Stone maze was also normal relative to controls in rats treated with CYP/5FU. The results contribute to a growing literature suggesting that learning and memory mediated by the hippocampus can be relatively resistant to chemotherapy. Future investigation may need to focus on assessments of processing speed, executive function and attention, and the possible interactive contribution of cancer itself and aging to the post-treatment development of cognitive impairment. Copyright © 2011 Elsevier Inc. All rights reserved. JF - Pharmacology, biochemistry, and behavior AU - Long, Jeffrey M AU - Lee, Garrick D AU - Kelley-Bell, Bennett AU - Spangler, Edward L AU - Perez, Evelyn J AU - Longo, Dan L AU - de Cabo, Rafael AU - Zou, Sige AU - Rapp, Peter R AD - Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA. longjm@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 205 EP - 211 VL - 100 IS - 1 KW - Cyclophosphamide KW - 8N3DW7272P KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Rats KW - Fluorouracil -- administration & dosage KW - Cyclophosphamide -- administration & dosage KW - Fluorouracil -- adverse effects KW - Animals KW - Rats, Inbred F344 KW - Learning -- physiology KW - Treatment Outcome KW - Learning -- drug effects KW - Cognition Disorders -- chemically induced KW - Male KW - Cyclophosphamide -- adverse effects KW - Memory -- drug effects KW - Memory -- physiology KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/895854861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Preserved+learning+and+memory+following+5-fluorouracil+and+cyclophosphamide+treatment+in+rats.&rft.au=Long%2C+Jeffrey+M%3BLee%2C+Garrick+D%3BKelley-Bell%2C+Bennett%3BSpangler%2C+Edward+L%3BPerez%2C+Evelyn+J%3BLongo%2C+Dan+L%3Bde+Cabo%2C+Rafael%3BZou%2C+Sige%3BRapp%2C+Peter+R&rft.aulast=Long&rft.aufirst=Jeffrey&rft.date=2011-11-01&rft.volume=100&rft.issue=1&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=1873-5177&rft_id=info:doi/10.1016%2Fj.pbb.2011.08.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-07-23 N1 - Date created - 2011-09-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Breast. 2007 Dec;16 Suppl 2:S166-8 [17719225] Behav Brain Res. 2008 Jan 25;186(2):168-75 [17854921] Ann Oncol. 2008 Apr;19(4):623-9 [17974553] Psychopharmacology (Berl). 2008 Sep;199(4):527-38 [18463849] Ann Oncol. 2002 Sep;13(9):1387-97 [12196364] J Lab Clin Med. 2002 Nov;140(5):358-68 [12434138] Can J Physiol Pharmacol. 2002 Nov;80(11):1076-84 [12489927] J Int Neuropsychol Soc. 2003 Nov;9(7):967-82 [14738279] Science. 2004 May 7;304(5672):881-3 [15131309] Cancer. 2004 Jun 1;100(11):2292-9 [15160331] J Clin Oncol. 2004 Jun 1;22(11):2233-9 [15169812] Neurobiol Learn Mem. 2004 Nov;82(3):171-7 [15464402] Nature. 1982 Jun 24;297(5868):681-3 [7088155] Neurobiol Aging. 1988 Sep-Dec;9(5-6):475-85 [3062459] Physiol Behav. 1990 Jan;47(1):207-12 [2326338] Neurobiol Aging. 1995 Jan-Feb;16(1):85-9 [7723940] Physiol Behav. 1996 Jan;59(1):153-6 [8848475] Brain Cogn. 2005 Oct;59(1):60-70 [15975700] J Clin Oncol. 2005 Nov 1;23(31):8025-32 [16258100] Cancer. 2005 Nov 15;104(10):2222-33 [16206292] Clin Cancer Res. 2006 Jan 1;12(1):198-205 [16397043] Clin Neuropsychol. 2006 Feb;20(1):76-89 [16410227] Ann Oncol. 2006 Mar;17(3):415-23 [16357023] Br J Cancer. 2006 Mar 27;94(6):828-34 [16523200] Learn Mem. 2006 Jul-Aug;13(4):451-7 [16882861] Clin Cancer Res. 2006 Aug 15;12(16):5000; author reply 5000-1 [16914590] J Clin Oncol. 2006 Nov 10;24(32):5132-7 [17093275] Pharmacol Biochem Behav. 2006 Sep;85(1):66-75 [16935324] Cancer. 2007 May 1;109(9):1905-13 [17351951] Behav Brain Res. 2007 Jul 19;181(1):168-72 [17509697] Eur J Neurosci. 2008 Jul;28(2):323-30 [18702703] Metab Brain Dis. 2008 Sep;23(3):325-33 [18690526] Cancer. 2008 Nov 1;113(9):2431-9 [18823033] Neuroscience. 2008 Nov 11;157(1):95-104 [18835334] Behav Brain Res. 2009 Aug 12;201(2):279-84 [19428645] South Med J. 2009 Sep;102(9):929-34 [19668023] Pharmacol Biochem Behav. 2009 Dec;94(2):239-43 [19747935] Behav Brain Res. 2010 May 1;209(1):66-72 [20096731] Cancer. 2010 Jul 15;116(14):3348-56 [20564075] Pharmacol Biochem Behav. 2010 Dec;97(2):333-9 [20828582] Brain Res Bull. 2008 Nov 25;77(5):237-40 [18755251] Neurosci Biobehav Rev. 2011 Jan;35(3):729-41 [20869395] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.pbb.2011.08.012 ER - TY - JOUR T1 - Intranasal Administration of Adeno-associated Virus Type 12 (AAV12) Leads to Transduction of the Nasal Epithelia and Can Initiate Transgene-specific Immune Response AN - 1668268795; PQ0001244374 AB - A critical aspect in defining the utility of a vector for gene therapy applications is the cell tropism and biodistribution of the vector. Adeno-associated virus type 12 (AAV12) has several unique biological and immunological properties that could be exploited for gene therapy purposes, including a unique cell surface receptor, transduction of epithelial cells, and limited neutralization by pooled human antibodies. However, little is known about its cell tropism and biodistribution in vivo. In vivo biodistribution studies with AAV12 vectors encoding a cytomegalovirus promoted luciferase transgene indicated preferential transduction of the nasal epithelia which was not observed with AAV2-based vectors. Expression peaked 2 weeks postadministration, before decreasing to a persistent level. The level of neutralizing antibodies (Nab) induced was sevenfold lower for AAV12 than for AAV2, an advantage for use in repeat administration. Furthermore, vectors encoding influenza A nucleoprotein (NP), an antigen which has previously been shown to induce immune protection against challenge, resulted in generation of both anti-A/NP antibodies and lung anti-A/NP T cells. Our findings suggest further evaluation of AAV12 as a vector for gene therapy and as a potential nasal vaccine. JF - Molecular Therapy AU - Quinn, Kathrina AU - Quirion, Mary R AU - Lo, Chia-Yun AU - Misplon, Julia A AU - Epstein, Suzanne L AU - Chiorini, John A AD - Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA, jchiorini@dir.nidcr.nih.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1990 EP - 1998 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 19 IS - 11 SN - 1525-0016, 1525-0016 KW - Genetics Abstracts; Virology & AIDS Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Cell surface KW - Epithelial cells KW - Receptor mechanisms KW - Gene therapy KW - Influenza A KW - Nucleoproteins KW - Tropism KW - Transgenes KW - Cytomegalovirus KW - Adeno-associated virus KW - Expression vectors KW - Antibodies KW - Intranasal administration KW - Lung KW - Lymphocytes T KW - Immune response KW - Vaccines KW - W 30905:Medical Applications KW - V 22350:Immunology KW - G 07730:Development & Cell Cycle KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668268795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=Intranasal+Administration+of+Adeno-associated+Virus+Type+12+%28AAV12%29+Leads+to+Transduction+of+the+Nasal+Epithelia+and+Can+Initiate+Transgene-specific+Immune+Response&rft.au=Quinn%2C+Kathrina%3BQuirion%2C+Mary+R%3BLo%2C+Chia-Yun%3BMisplon%2C+Julia+A%3BEpstein%2C+Suzanne+L%3BChiorini%2C+John+A&rft.aulast=Quinn&rft.aufirst=Kathrina&rft.date=2011-11-01&rft.volume=19&rft.issue=11&rft.spage=1990&rft.isbn=&rft.btitle=&rft.title=Molecular+Therapy&rft.issn=15250016&rft_id=info:doi/10.1038%2Fmt.2011.146 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Cell surface; Gene therapy; Receptor mechanisms; Influenza A; Transgenes; Tropism; Nucleoproteins; Expression vectors; Antibodies; Intranasal administration; Lung; Lymphocytes T; Vaccines; Immune response; Cytomegalovirus; Adeno-associated virus DO - http://dx.doi.org/10.1038/mt.2011.146 ER - TY - JOUR T1 - Personalized Cell Transfer Immunotherapy for B-Cell Malignancies and Solid Cancers AN - 1668249000; PQ0001244366 AB - Two independent groups have now corroborated and extended our earlier report[1] that the administration of autologous cells transduced with a chimeric antigen receptor (CAR) targeting the CD19 molecule could eradicate CD19 super(+) B-lineage cells in humans and was associated with the regression of advanced follicular lymphoma.[2-4] These studies have opened opportunities to tailor the genetic modification of autologous lymphocytes with receptors suitable for antigens presented on a patient's unique cancer and thus personalize cancer immunotherapy. JF - Molecular Therapy AU - Rosenberg, Steven A AU - Kochenderfer, James N AD - Surgery Branch, National Cancer Institute, National Institutes of Health, CRC-10, 10 Center Drive, Room 3-3940, Bethesda, Maryland 20892, USA, sar@nih.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1928 EP - 1930 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 19 IS - 11 SN - 1525-0016, 1525-0016 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Malignancy KW - Lymphocytes B KW - Immunotherapy KW - Lymphocytes KW - Cancer KW - CD19 antigen KW - F 06960:Molecular Immunology KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668249000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=Personalized+Cell+Transfer+Immunotherapy+for+B-Cell+Malignancies+and+Solid+Cancers&rft.au=Rosenberg%2C+Steven+A%3BKochenderfer%2C+James+N&rft.aulast=Rosenberg&rft.aufirst=Steven&rft.date=2011-11-01&rft.volume=19&rft.issue=11&rft.spage=1928&rft.isbn=&rft.btitle=&rft.title=Molecular+Therapy&rft.issn=15250016&rft_id=info:doi/10.1038%2Fmt.2011.223 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Malignancy; Lymphocytes B; Immunotherapy; Lymphocytes; Cancer; CD19 antigen DO - http://dx.doi.org/10.1038/mt.2011.223 ER - TY - JOUR T1 - Brief Assessment of Motor Function: Content Validity and Reliability of the Upper Extremity Gross Motor Scale AN - 1512194371; 201404704 AB - Content validity and reliability of the Brief Assessment of Motor Function (BAMF) Upper Extremity Gross Motor Scale (UEGMS) were evaluated in this prospective, descriptive study. The UEGMS is one of five BAMF ordinal scales designed for quick documentation of gross, fine, and oral motor skill levels. Designed to be independent of age and diagnosis, it is intended for use for infants through young adults. An expert panel of 17 physical therapists and 13 occupational therapists refined the content by responding to a standard questionnaire comprised of questions, which asked whether each item should be included, is clearly worded, should be reordered higher or lower, is functionally relevant, and is easily discriminated. Ratings of content validity exceeded the criterion except for two items, which may represent different perspectives of physical and occupational therapists. The UEGMS was modified using the quantitative and qualitative feedback from the questionnaires. For reliability, five raters scored videotaped motor performances of 10 children. Coefficients for inter-rater (0.94) and intra-rater (0.95) reliability were high. The results provide evidence of content validity and reliability of the UEGMS for the assessment of UEGM skill. Adapted from the source document. JF - Physical and Occupational Therapy in Pediatrics AU - Cintas, Holly Lea AU - Parks, Rebecca AU - Don, Sarah AU - Gerber, Lynn AD - Research Coordinator, Physical Therapy Section, Rehabilitation Medicine Department, Mark O. Hatfield Clinical Research Center, National Institutes of Health, Maryland, USA holly_cintas@nih.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 440 EP - 450 PB - Informa Healthcare, New York NY VL - 31 IS - 4 SN - 0194-2638, 0194-2638 KW - Evidence-based practice, knowledge translation, mobility, motor development KW - Assessment KW - Motor skills KW - Reliability KW - Motor performance KW - Occupational therapists KW - Upper limbs KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1512194371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physical+and+Occupational+Therapy+in+Pediatrics&rft.atitle=Brief+Assessment+of+Motor+Function%3A+Content+Validity+and+Reliability+of+the+Upper+Extremity+Gross+Motor+Scale&rft.au=Cintas%2C+Holly+Lea%3BParks%2C+Rebecca%3BDon%2C+Sarah%3BGerber%2C+Lynn&rft.aulast=Cintas&rft.aufirst=Holly&rft.date=2011-11-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-04-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Reliability; Occupational therapists; Assessment; Upper limbs; Motor performance; Motor skills DO - http://dx.doi.org/10.3109/01942638.2011.572148 ER - TY - JOUR T1 - The National Institutes of Health Commitment to Research on Women and Girls and AIDS AN - 1081895461; 201224055 AB - The National Institutes of Health has established the largest and most significant AIDS research program in the world through a comprehensive agenda of basic, clinical, translational, behavioral, and social sciences research on HIV infection and its associated co-infections, opportunistic infections, malignancies, and other complications. Part of a special journal issue on the subject, 'Bringing Gender Home: Implementing Gender-Responsive HIV/AIDS Programming for U.S. Women and Girls', the result of a 2-day meeting in 2010, a partnership with UNAIDS and the U.S. Office on Women's Health aimed at promoting 'increased leadership in gender-responsive programming for women and girls.'. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Brown, Anissa J AU - Bates, Angela AD - Office of AIDS Research, Office of the Director, National Institutes of Health, Bethesda, MD 20892 brownani@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - S239 EP - S240 PB - Elsevier Science, New York NY VL - 21 IS - 6s SN - 1049-3867, 1049-3867 KW - Medical research KW - Girls KW - Women KW - Health KW - Infection KW - HIV KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081895461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=The+National+Institutes+of+Health+Commitment+to+Research+on+Women+and+Girls+and+AIDS&rft.au=Brown%2C+Anissa+J%3BBates%2C+Angela&rft.aulast=Brown&rft.aufirst=Anissa&rft.date=2011-11-01&rft.volume=21&rft.issue=6s&rft.spage=S239&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2011.05.006 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - HIV; Women; Girls; Health; Medical research; Infection DO - http://dx.doi.org/10.1016/j.whi.2011.05.006 ER - TY - JOUR T1 - Decreased microRNA-214 levels in breast cancer cells coincides with increased cell proliferation, invasion and accumulation of the Polycomb Ezh2 methyltransferase AN - 1028078982; 16119965 AB - MicroRNAs (miRNAs) are small non-coding RNAs, which regulate gene expression by inhibiting translation or promoting degradation of specific target messenger RNAs (mRNAs). Alteration of the levels of a number of miRNAs is common in solid and hematological tumors. We have shown previously that miR-214 regulates Ezh2 in skeletal muscle and embryonic stem cells. The current study was aimed at examining the role of miR-214 in breast cancer where miR-214 levels are reduced but whether this phenomenon bears a functional relevance is unknown. MiR-214 expression was inversely correlated with Ezh2 mRNA and protein levels in breast cancer cell lines and at least one copy of the miR-214 alleles was found to be deleted in 24% (6/25) of primary breast tumors. Experimental increase of miR-214 in breast cancer cell lines correlated with reduction of Ezh2 protein levels, a known marker of invasion and aggressive breast cancer behavior. Supporting a direct targeting mechanism, miR-214 decreased luciferase activity from a construct containing the Ezh2 3' untranslated region. Expression of miR-214 specifically reduced cell proliferation of breast cancer cells and inhibited the invasive potential of a highly metastatic breast cancer cell line. These findings indicate that reduced miR-214 levels may contribute to breast tumorigenesis by allowing abnormally elevated Ezh2 accumulation and subsequent unchecked cell proliferation and invasion. JF - Carcinogenesis AU - Derfoul, Assia AU - Juan, Aster H AU - Difilippantonio, Michael J AU - Palanisamy, Nallasivam AU - Ried, Thomas AU - Sartorelli, Vittorio AD - 1 Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-8022, USA, sartorev@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1607 EP - 1614 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 32 IS - 11 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Translation KW - Invasiveness KW - polycomb group proteins KW - Tumorigenesis KW - miRNA KW - non-coding RNA KW - Aggressive behavior KW - mRNA KW - Gene expression KW - Metastases KW - Tumor cell lines KW - Stem cells KW - Methyltransferase KW - Embryo cells KW - Carcinogenesis KW - Breast cancer KW - Skeletal muscle KW - Cell proliferation KW - N 14830:RNA KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028078982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Decreased+microRNA-214+levels+in+breast+cancer+cells+coincides+with+increased+cell+proliferation%2C+invasion+and+accumulation+of+the+Polycomb+Ezh2+methyltransferase&rft.au=Derfoul%2C+Assia%3BJuan%2C+Aster+H%3BDifilippantonio%2C+Michael+J%3BPalanisamy%2C+Nallasivam%3BRied%2C+Thomas%3BSartorelli%2C+Vittorio&rft.aulast=Derfoul&rft.aufirst=Assia&rft.date=2011-11-01&rft.volume=32&rft.issue=11&rft.spage=1607&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgr184 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Last updated - 2013-11-15 N1 - SubjectsTermNotLitGenreText - Translation; Invasiveness; polycomb group proteins; miRNA; Tumorigenesis; non-coding RNA; Aggressive behavior; mRNA; Metastases; Gene expression; Stem cells; Tumor cell lines; Methyltransferase; Embryo cells; Carcinogenesis; Breast cancer; Skeletal muscle; Cell proliferation DO - http://dx.doi.org/10.1093/carcin/bgr184 ER - TY - JOUR T1 - In vivo detection of intermediate metabolic products of [1-13C]ethanol in the brain using 13C MRS AN - 1017970019; 16700453 AB - In this study, in vivo13C MRS was used to investigate the labeling of brain metabolites after intravenous administration of [1-13C]ethanol. After [1-13C]ethanol had been administered systemically to rats, 13C labels were detected in glutamate, glutamine and aspartate in the carboxylic and amide carbon spectral region. 13C-labeled bicarbonate HCO (161.0ppm) was also detected. Saturating acetaldehyde C1 at 207.0ppm was found to have no effect on the ethanol C1 (57.7ppm) signal intensity after extensive signal averaging, providing direct in vivo evidence that direct metabolism of alcohol by brain tissue is minimal. To compare the labeling of brain metabolites by ethanol with labeling by glucose, in vivo time course data were acquired during intravenous co-infusion of [1-13C]ethanol and [13C6]-D-glucose. In contrast with labeling by [13C6]-D-glucose, which produced doublets of carboxylic/amide carbons with a J coupling constant of 51Hz, the simultaneously detected glutamate and glutamine singlets were labeled by [1-13C]ethanol. As 13C labels originating from ethanol enter the brain after being converted into [1-13C]acetate in the liver, and the direct metabolism of ethanol by brain tissue is negligible, it is suggested that orally or intragastrically administered 13C-labeled ethanol may be used to study brain metabolism and glutamatergic neurotransmission in investigations involving alcohol administration. In vivo13C MRS of rat brain following intragastric administration of 13C-labeled ethanol is demonstrated. Published in 2011 by John Wiley & Sons, Ltd. JF - NMR in Biomedicine AU - Xiang, Yun AU - Shen, Jun Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 1054 EP - 1062 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 24 IS - 9 SN - 1099-1492, 1099-1492 KW - Biotechnology and Bioengineering Abstracts KW - Glutamine KW - Intravenous administration KW - Data processing KW - Acetaldehyde KW - Glucose KW - Brain KW - Bicarbonate KW - Metabolites KW - Glutamatergic transmission KW - Carbon KW - Neurotransmission KW - Liver KW - N.M.R. KW - Glutamic acid KW - amides KW - Ethanol KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017970019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=In+vivo+detection+of+intermediate+metabolic+products+of+%5B1-13C%5Dethanol+in+the+brain+using+13C+MRS&rft.au=Xiang%2C+Yun%3BShen%2C+Jun&rft.aulast=Xiang&rft.aufirst=Yun&rft.date=2011-11-01&rft.volume=24&rft.issue=9&rft.spage=1054&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=10991492&rft_id=info:doi/10.1002%2Fnbm.1653 L2 - http://onlinelibrary.wiley.com/doi/10.1002/nbm.1653/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Intravenous administration; Glutamine; Data processing; Acetaldehyde; Brain; Glucose; Metabolites; Bicarbonate; Glutamatergic transmission; Carbon; Neurotransmission; Liver; N.M.R.; Glutamic acid; amides; Ethanol DO - http://dx.doi.org/10.1002/nbm.1653 ER - TY - JOUR T1 - Serum thyroglobulin, a biomarker for iodine deficiency, is not associated with increased risk of upper gastrointestinal cancers in a large Chinese cohort AN - 1017965016; 16689741 AB - Iodine concentrates in gastric tissue and may act as an antioxidant for the stomach. We previously showed that self-reported goiter was associated with significantly increased risk of gastric noncardia adenocarcinoma (GNCA) and nonsignificantly increased risks of gastric cardia adenocarcinoma (GCA) and esophageal squamous cell carcinoma (ESCC) in a prospective case-cohort study in a high-risk population in China. Negatively correlated with iodine levels, serum thyroglobulin (Tg) is a more sensitive biomarker of iodine deficiency than goiter. Our study aimed to determine whether baseline serum Tg was also associated with development of GNCA, GCA and ESCC in the same cohort, the Linxian General Population Nutrition Intervention Trial. Sera from ~200 subjects of each case type and 400 noncases were tested for serum Tg concentration using appropriate assays. Tg was modeled as sex- and assay-specific quartiles in Cox regression models adjusted for age, smoking, alcohol, Helicobacter pylori status, pepsinogens I/II ratio, family history and commune of residence. In the final combined analysis, participants in the highest quartile of serum Tg, compared to those in the lowest quartile, had adjusted hazard ratios of 0.88 (95% confidence interval 0.50-1.52), 1.14 (0.63-2.05) and 0.78 (0.47-1.31) for GNCA, GCA and ESCC, respectively. Using serum Tg, a sensitive biomarker of iodine deficiency, we found no association between serum Tg concentrations and risk of these upper gastrointestinal (UGI) cancers in the study population. Our results do not support the hypothesis that iodine deficiency, as assessed by serum Tg, is associated with an increased risk of UGI cancers. JF - International Journal of Cancer AU - Lin, Shih-Wen AU - Fan, Jin-Hu AU - Dawsey, Sanford M AU - Taylor, Philip R AU - Qiao, You-Lin AU - Abnet, Christian C AD - Cancer Prevention Fellowship Program, National Cancer Institute, Bethesda, MD, lins4@mail.nih.gov Y1 - 2011/11/01/ PY - 2011 DA - 2011 Nov 01 SP - 2284 EP - 2289 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 129 IS - 9 SN - 1097-0215, 1097-0215 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Alcohol KW - Antioxidants KW - Bioindicators KW - Cancer KW - Genetics KW - Intervention KW - Iodine KW - Nutrition KW - intervention KW - Helicobacter pylori KW - China, People's Rep. KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017965016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Serum+thyroglobulin%2C+a+biomarker+for+iodine+deficiency%2C+is+not+associated+with+increased+risk+of+upper+gastrointestinal+cancers+in+a+large+Chinese+cohort&rft.au=Lin%2C+Shih-Wen%3BFan%2C+Jin-Hu%3BDawsey%2C+Sanford+M%3BTaylor%2C+Philip+R%3BQiao%2C+You-Lin%3BAbnet%2C+Christian+C&rft.aulast=Lin&rft.aufirst=Shih-Wen&rft.date=2011-11-01&rft.volume=129&rft.issue=9&rft.spage=2284&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=10970215&rft_id=info:doi/10.1002%2Fijc.25789 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ijc.25789/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Bioindicators; Alcohol; Genetics; Age; Antioxidants; intervention; Intervention; Iodine; Nutrition; Cancer; Helicobacter pylori; China, People's Rep. DO - http://dx.doi.org/10.1002/ijc.25789 ER - TY - CPAPER T1 - Cyber bullying and victimization among US adolescents T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313017879; 6051486 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Wang, Jing AU - Iannotti, Ronald Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - victimization KW - cyberbullying KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313017879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Cyber+bullying+and+victimization+among+US+adolescents&rft.au=Wang%2C+Jing%3BIannotti%2C+Ronald&rft.aulast=Wang&rft.aufirst=Jing&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - In Search of better Strategies to Meet MDG 4 & 5 T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313013375; 6048734 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Wright, Linda Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313013375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=In+Search+of+better+Strategies+to+Meet+MDG+4+%26amp%3B+5&rft.au=Wright%2C+Linda&rft.aulast=Wright&rft.aufirst=Linda&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Using Social Media to Reach Women with The Heart Truth T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313009362; 6048508 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Taubenheim, Ann Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Heart UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313009362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Using+Social+Media+to+Reach+Women+with+The+Heart+Truth&rft.au=Taubenheim%2C+Ann&rft.aulast=Taubenheim&rft.aufirst=Ann&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Engaging communities in setting and prioritizing health communication research agenda T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313008660; 6049459 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Chou, Wen-ying AU - Keefe, Brian AU - Sanders, Amy AU - Hesse, Bradford Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Communication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313008660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=In-vivo+optical+measurement+of+direct-+and+indirect-pathway+striatal+neuron+activity+in+mice+performing+an+operant+task&rft.au=Cui%2C+G%3BJun%2C+S%3BJin%2C+X%3BVogel%2C+S%3BLovinger%2C+D%3BCosta%2C+R&rft.aulast=Cui&rft.aufirst=G&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Impact of social media in disseminating cancer information to multicultural communities T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313007238; 6048279 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Alexander, James AU - Joseph, Natalie AU - Kwon, Harry AU - Bartholomew, Jill AU - Padberg, Rose AU - Kiourkas, Iliana AU - Hale, Lena AU - Devine, Theresa AU - Greenwood, Addison AU - La Porta, Madeline Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Cancer KW - culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313007238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Impact+of+social+media+in+disseminating+cancer+information+to+multicultural+communities&rft.au=Alexander%2C+James%3BJoseph%2C+Natalie%3BKwon%2C+Harry%3BBartholomew%2C+Jill%3BPadberg%2C+Rose%3BKiourkas%2C+Iliana%3BHale%2C+Lena%3BDevine%2C+Theresa%3BGreenwood%2C+Addison%3BLa+Porta%2C+Madeline&rft.aulast=Alexander&rft.aufirst=James&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Assessing the public health impact of personalized medicine T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313006178; 6051084 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Wacholder, Sholom Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313006178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Assessing+the+public+health+impact+of+personalized+medicine&rft.au=Wacholder%2C+Sholom&rft.aulast=Wacholder&rft.aufirst=Sholom&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - On the Road to Personalized Genomic Medicine in Oncology T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313006163; 6051083 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Simon, Richard Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Oncology KW - genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313006163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=On+the+Road+to+Personalized+Genomic+Medicine+in+Oncology&rft.au=Simon%2C+Richard&rft.aulast=Simon&rft.aufirst=Richard&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Relations between child-reported food exposure and preferences, and parent-reported food availability to child dietary intake and quality T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313000101; 6050115 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Lipsky, Leah AU - Nansel, Tonja AU - Haynie, Denise AU - Mehta, Sanjeev AU - Laffel, Lori Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Ingestion KW - Diets KW - food availability KW - Food preferences KW - Dietary intake KW - Food quality KW - Food availability UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313000101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Relations+between+child-reported+food+exposure+and+preferences%2C+and+parent-reported+food+availability+to+child+dietary+intake+and+quality&rft.au=Lipsky%2C+Leah%3BNansel%2C+Tonja%3BHaynie%2C+Denise%3BMehta%2C+Sanjeev%3BLaffel%2C+Lori&rft.aulast=Lipsky&rft.aufirst=Leah&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Harmonization of Diagnostic Criteria for Hemoglobinopathies among State NBS Programs T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312995106; 6051761 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Werner, Ellen AU - Hassell, Kathryn Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Hemoglobinopathy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312995106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Harmonization+of+Diagnostic+Criteria+for+Hemoglobinopathies+among+State+NBS+Programs&rft.au=Werner%2C+Ellen%3BHassell%2C+Kathryn&rft.aulast=Werner&rft.aufirst=Ellen&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Developing standard names and codes for lysosomal storage disorders detectable by newborn screening T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312995066; 6051760 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Goodwin, Rebecca AU - Watson, Michael AU - Matern, Dietrich AU - Hill, J AU - Cuthbert, Carla AU - Abhyankar, Swapna AU - Copeland, Sara AU - Urv, Tiina AU - Sarkar, Deboshree AU - McDonald, Clement Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Storage KW - lysosomal storage diseases KW - Neonates KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312995066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Developing+standard+names+and+codes+for+lysosomal+storage+disorders+detectable+by+newborn+screening&rft.au=Goodwin%2C+Rebecca%3BWatson%2C+Michael%3BMatern%2C+Dietrich%3BHill%2C+J%3BCuthbert%2C+Carla%3BAbhyankar%2C+Swapna%3BCopeland%2C+Sara%3BUrv%2C+Tiina%3BSarkar%2C+Deboshree%3BMcDonald%2C+Clement&rft.aulast=Goodwin&rft.aufirst=Rebecca&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Primary care providers' use of risk factors and test results to determine human papillomavirus vaccine receipt T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312993389; 6051402 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Kepka, Deanna AU - Saraiya, Mona AU - Benard, Vicki AU - Berkowitz, Zahava AU - Roland, Katherine AU - Yabroff, K Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - vaccines KW - Risk factors KW - Vaccines KW - Disease control KW - Human papillomavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312993389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Primary+care+providers%27+use+of+risk+factors+and+test+results+to+determine+human+papillomavirus+vaccine+receipt&rft.au=Kepka%2C+Deanna%3BSaraiya%2C+Mona%3BBenard%2C+Vicki%3BBerkowitz%2C+Zahava%3BRoland%2C+Katherine%3BYabroff%2C+K&rft.aulast=Kepka&rft.aufirst=Deanna&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - State laws for time spent in Physical education and its relationship with adolescent weight status T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312992473; 6048319 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Oh, April AU - Hennessey, Erin AU - Perna, Frank AU - Agurs-Collins, Tanya AU - Chriqui, Jamie AU - Masse, Louise Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Adolescents KW - Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312992473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=State+laws+for+time+spent+in+Physical+education+and+its+relationship+with+adolescent+weight+status&rft.au=Oh%2C+April%3BHennessey%2C+Erin%3BPerna%2C+Frank%3BAgurs-Collins%2C+Tanya%3BChriqui%2C+Jamie%3BMasse%2C+Louise&rft.aulast=Oh&rft.aufirst=April&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Communicating risk from soil sediment contamination post-Hurricane Ike during storm recovery efforts in coastal Texas and Louisiana T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312988750; 6051481 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Sullivan, John AU - Nolen, Alexandra AU - Croisant, Sharon AU - Subra, Wilma AU - Jackson, Michael AU - Ward, Jonathan Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - USA, Louisiana KW - USA, Texas KW - Soil pollution KW - Storms KW - Sediment pollution KW - Contamination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312988750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Striosomal+and+extended+striatal+expression+of+the+CB1+cannabinoid+receptor+during+development+and+in+the+mature+mouse&rft.au=Davis%2C+M%3BLovinger%2C+D&rft.aulast=Davis&rft.aufirst=M&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Importance of comparable state and local health survey data for research to improve population health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312988071; 6050371 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Portnoy, Barry AU - Balluz, Lina Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312988071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Importance+of+comparable+state+and+local+health+survey+data+for+research+to+improve+population+health&rft.au=Portnoy%2C+Barry%3BBalluz%2C+Lina&rft.aulast=Portnoy&rft.aufirst=Barry&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A review of NIH's Office of Behavioral and Social Sciences Research (OBSSR) major activities T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312982716; 6051240 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Mabry, Patty Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - social sciences KW - Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312982716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=A+review+of+NIH%27s+Office+of+Behavioral+and+Social+Sciences+Research+%28OBSSR%29+major+activities&rft.au=Mabry%2C+Patty&rft.aulast=Mabry&rft.aufirst=Patty&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - SSA-NIH-BU collaboration to improve the disability determination process: A conceptual and operational approach based on contemporary paradigms and novel assessment methods T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312979118; 6050074 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Rasch, Elizabeth AU - Brandt, Diane AU - Chan, Leighton Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - disabilities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312979118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Two+critical+and+functionally+distinct+time+periods+for+early+face+and+body+perception&rft.au=Pitcher%2C+D%3BDuchaine%2C+B%3BWalsh%2C+V%3BKanwisher%2C+N&rft.aulast=Pitcher&rft.aufirst=D&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - ONE CIRCLE (Organizing Nurses to Engage Communities In Research and Collaborations Linking Evidence) to Address Youth Alcohol Use in a Reservation Community T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312979051; 6051614 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Brockie, Teresa AU - Adams, Kathleen AU - Goodman, Desiree AU - Kellam, Anita AU - Koratich, Chad AU - Elliott, Dolores AU - Kub, Joan AU - Fisher, Cheryl AU - Wallen, Gwenyth Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - nursing KW - alcohols KW - Medical personnel UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312979051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=ONE+CIRCLE+%28Organizing+Nurses+to+Engage+Communities+In+Research+and+Collaborations+Linking+Evidence%29+to+Address+Youth+Alcohol+Use+in+a+Reservation+Community&rft.au=Brockie%2C+Teresa%3BAdams%2C+Kathleen%3BGoodman%2C+Desiree%3BKellam%2C+Anita%3BKoratich%2C+Chad%3BElliott%2C+Dolores%3BKub%2C+Joan%3BFisher%2C+Cheryl%3BWallen%2C+Gwenyth&rft.aulast=Brockie&rft.aufirst=Teresa&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Research Priorities and Funding Opportunities and Mechanisms of NIAMS Related to Back Pain T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312976714; 6049247 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Panagis, James Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - back pain KW - Pain KW - Financing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312976714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Research+Priorities+and+Funding+Opportunities+and+Mechanisms+of+NIAMS+Related+to+Back+Pain&rft.au=Panagis%2C+James&rft.aulast=Panagis&rft.aufirst=James&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Communicating and Applying the 2010 Dietary Guidelines for Americans: Resources for Public Health Practice T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312975666; 6048982 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Shaikh, Abdul Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Diets KW - guidelines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312975666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Communicating+and+Applying+the+2010+Dietary+Guidelines+for+Americans%3A+Resources+for+Public+Health+Practice&rft.au=Shaikh%2C+Abdul&rft.aulast=Shaikh&rft.aufirst=Abdul&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Methods and Management: NIH Administrators, Risk Factor Epidemiology, and the Framingham Heart Study T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312972066; 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6050392 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Alvarado, Matilde AU - Vasquez, Esperanza AU - Balcazar, Hector AU - Brownstein, J Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Sustainability KW - Resource management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312970655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Sustainability+in+CHW+Community+Programs&rft.au=Alvarado%2C+Matilde%3BVasquez%2C+Esperanza%3BBalcazar%2C+Hector%3BBrownstein%2C+J&rft.aulast=Alvarado&rft.aufirst=Matilde&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Evidence-based case study materials to support the ANA environmental health nursing practice standard T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312969404; 6049944 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Backus, Ann AU - Hewitt, Jeanne AU - Chalupka, Stephanie Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - case studies KW - Environmental health KW - Nursing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312969404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Evidence-based+case+study+materials+to+support+the+ANA+environmental+health+nursing+practice+standard&rft.au=Backus%2C+Ann%3BHewitt%2C+Jeanne%3BChalupka%2C+Stephanie&rft.aulast=Backus&rft.aufirst=Ann&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Psychosocial Predictors of Observed Speeding Among Teenage Drivers During the First 18-Month of Licensure T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312968646; 6049831 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Simons-Morton, Bruce Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312968646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Psychosocial+Predictors+of+Observed+Speeding+Among+Teenage+Drivers+During+the+First+18-Month+of+Licensure&rft.au=Simons-Morton%2C+Bruce&rft.aulast=Aldworth&rft.aufirst=Z&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Understanding eating episodes: Predominant activities reported by US adults when eating or drinking in the American Time Use Survey T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312968541; 6050702 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Oh, April AU - Erinosho, Temitope AU - Fridlund Dunton, Genevieve AU - Nebeling, Linda Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Drinking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312968541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Understanding+eating+episodes%3A+Predominant+activities+reported+by+US+adults+when+eating+or+drinking+in+the+American+Time+Use+Survey&rft.au=Oh%2C+April%3BErinosho%2C+Temitope%3BFridlund+Dunton%2C+Genevieve%3BNebeling%2C+Linda&rft.aulast=Oh&rft.aufirst=April&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Revised criteria for DSM-V substance use disorders T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312962973; 6048874 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Grant, Bridget Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - substance use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312962973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Polyamidoamine+%28PAMAM%29+dendrimer+conjugates+of+neuroprotective+adenosine+receptor+antagonists&rft.au=Jacobson%2C+K%3BKumar%2C+T%3BDeflorian%2C+F%3BKecskes%2C+A%3BPhan%2C+K%3BGao%2C+Z%3BTosh%2C+D&rft.aulast=Jacobson&rft.aufirst=K&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Terminology of substance use disorders for DSM-V T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312962650; 6048872 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Compton, Wilson Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - substance use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312962650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Terminology+of+substance+use+disorders+for+DSM-V&rft.au=Compton%2C+Wilson&rft.aulast=Compton&rft.aufirst=Wilson&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Weight, weight perceptions and health-related quality of life among youth T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312961523; 6051716 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Farhat, Tilda AU - Iannotti, Ronald Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - quality of life KW - Perception KW - Quality of life UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312961523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Weight%2C+weight+perceptions+and+health-related+quality+of+life+among+youth&rft.au=Farhat%2C+Tilda%3BIannotti%2C+Ronald&rft.aulast=Farhat&rft.aufirst=Tilda&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Interactions between toxic environmental exposures and infectious diseases T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312958818; 6048653 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Birnbaum, Linda Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Infectious diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312958818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Interactions+between+toxic+environmental+exposures+and+infectious+diseases&rft.au=Birnbaum%2C+Linda&rft.aulast=Birnbaum&rft.aufirst=Linda&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Urban sprawl and cancer mortality in the United States T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312956891; 6048277 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Berrigan, David AU - Tatalovich, Zaria AU - Ewing, Reid AU - Pickle, Linda AU - Ballard-Barbash, Rachel Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - USA KW - Cancer KW - urban sprawl KW - Mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312956891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Urban+sprawl+and+cancer+mortality+in+the+United+States&rft.au=Berrigan%2C+David%3BTatalovich%2C+Zaria%3BEwing%2C+Reid%3BPickle%2C+Linda%3BBallard-Barbash%2C+Rachel&rft.aulast=Berrigan&rft.aufirst=David&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - NCCAM's Health Care Provider Portal: A Two-Pronged Approach to Evaluating an Online Health Education Program T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312956754; 6048492 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Stout, Shawn Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Education KW - Health care KW - Internet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312956754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=NCCAM%27s+Health+Care+Provider+Portal%3A+A+Two-Pronged+Approach+to+Evaluating+an+Online+Health+Education+Program&rft.au=Stout%2C+Shawn&rft.aulast=Stout&rft.aufirst=Shawn&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Analysis of the compassionate allowance (CAL) program: A systematic data-driven approach to identifying potential CAL conditions T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312956410; 6050077 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Ho, Pei-Shu AU - Huynh, Minh AU - Heuser, Aaron AU - Houtenville, Andew AU - Wheatcroft, Gloria AU - Chan, Leighton AU - Rasch, Elizabeth Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312956410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Analysis+of+the+compassionate+allowance+%28CAL%29+program%3A+A+systematic+data-driven+approach+to+identifying+potential+CAL+conditions&rft.au=Ho%2C+Pei-Shu%3BHuynh%2C+Minh%3BHeuser%2C+Aaron%3BHoutenville%2C+Andew%3BWheatcroft%2C+Gloria%3BChan%2C+Leighton%3BRasch%2C+Elizabeth&rft.aulast=Ho&rft.aufirst=Pei-Shu&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Building community resiliency and environmental justice through health and safety training T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312954794; 6048778 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Beard, Sharon Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Training KW - Environmental equity KW - Health and safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312954794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Building+community+resiliency+and+environmental+justice+through+health+and+safety+training&rft.au=Beard%2C+Sharon&rft.aulast=Beard&rft.aufirst=Sharon&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Use of complementary and alternative medicine during active surveillance among prostate cancer patients T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312943622; 6050577 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Al-Keliddar, Miriam AU - Mikhail, Isis Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - prostate cancer KW - Prostate cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312943622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Use+of+complementary+and+alternative+medicine+during+active+surveillance+among+prostate+cancer+patients&rft.au=Al-Keliddar%2C+Miriam%3BMikhail%2C+Isis&rft.aulast=Al-Keliddar&rft.aufirst=Miriam&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Alliance Building: Mobilizing Partners to Share the Signs and Symptoms of COPD T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312928998; 6051604 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Ndenecho, Monique Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Chronic obstructive pulmonary disease KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312928998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Alliance+Building%3A+Mobilizing+Partners+to+Share+the+Signs+and+Symptoms+of+COPD&rft.au=Ndenecho%2C+Monique&rft.aulast=Ndenecho&rft.aufirst=Monique&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Change in body size during early adulthood and prevalence of diabetes mellitus T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312919059; 6048667 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Golozar, Asieh AU - Etemadi, Arash AU - Khademi, Hooman AU - Kamangar, Farin AU - Poustchi, Hossein AU - Islami, Farhad AU - Freedman, Neal AU - Taylor, Philip AU - Pharoah, Paul AU - Boffetta, Paulo AU - Brennan, Paul AU - Abnet, Christian AU - Dawsey, Sanford AU - Malekzadeh, Reza Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - diabetes mellitus KW - body size KW - Body size KW - Diabetes mellitus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312919059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Change+in+body+size+during+early+adulthood+and+prevalence+of+diabetes+mellitus&rft.au=Golozar%2C+Asieh%3BEtemadi%2C+Arash%3BKhademi%2C+Hooman%3BKamangar%2C+Farin%3BPoustchi%2C+Hossein%3BIslami%2C+Farhad%3BFreedman%2C+Neal%3BTaylor%2C+Philip%3BPharoah%2C+Paul%3BBoffetta%2C+Paulo%3BBrennan%2C+Paul%3BAbnet%2C+Christian%3BDawsey%2C+Sanford%3BMalekzadeh%2C+Reza&rft.aulast=Golozar&rft.aufirst=Asieh&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Assessing environmental exposures: State-of-the-art approaches for dust contamination T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312907449; 6051706 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Dellarco, Michael Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Dust KW - Contamination KW - Environmental assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312907449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Assessing+environmental+exposures%3A+State-of-the-art+approaches+for+dust+contamination&rft.au=Dellarco%2C+Michael&rft.aulast=Dellarco&rft.aufirst=Michael&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Domestic and international efforts in mental health by the National Institute of Mental Health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312906977; 6051431 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Collins, Pamela Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - mental disorders KW - Mental disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312906977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Domestic+and+international+efforts+in+mental+health+by+the+National+Institute+of+Mental+Health&rft.au=Collins%2C+Pamela&rft.aulast=Collins&rft.aufirst=Pamela&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Exploring the CHW Role: From Preparation to Practice T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312903619; 6050388 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Alvarado, Matilde Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312903619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Exploring+the+CHW+Role%3A+From+Preparation+to+Practice&rft.au=Alvarado%2C+Matilde&rft.aulast=Alvarado&rft.aufirst=Matilde&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Identifying a Conceptual Approach for Assessing the Influence of Father Involvement on Maternal and Child Health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312901175; 6049051 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Hill, Carl Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312901175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Identifying+a+Conceptual+Approach+for+Assessing+the+Influence+of+Father+Involvement+on+Maternal+and+Child+Health&rft.au=Hill%2C+Carl&rft.aulast=Hill&rft.aufirst=Carl&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8+ T Cell Immunity AN - 926892067; 15966847 AB - Our goal is to develop a vaccine that sustainably prevents Plasmodium falciparum (Pf) malaria in greater than or equal to 80% of recipients. Pf sporozoites (PfSPZ) administered by mosquito bites are the only immunogens shown to induce such protection in humans. Such protection is thought to be mediated by CD8+ T cells in the liver that secrete interferon- gamma (IFN- gamma ). We report that purified irradiated PfSPZ administered to 80 volunteers by needle inoculation in the skin was safe, but suboptimally immunogenic and protective. Animal studies demonstrated that intravenous immunization was critical for inducing a high frequency of PfSPZ-specific CD8+, IFN- gamma -producing T cells in the liver (nonhuman primates, mice) and conferring protection (mice). Our results suggest that intravenous administration of this vaccine will lead to the prevention of infection with Pf malaria. JF - Science (Washington) AU - Epstein, JE AU - Tewari, K AU - Lyke, KE AU - Sim, BKL AU - Billingsley, P F AU - Laurens, M B AU - Gunasekera, A AU - Chakravarty, S AU - James, E R AU - Sedegah, M AU - Richman, A AU - Velmurugan, S AU - Reyes, S AU - Li, M AU - Tucker, K AU - Ahumada, A AU - Ruben, A J AU - Li, T AU - Stafford, R AU - Eappen, A G AU - Tamminga, C AU - Bennett, J W AU - Ockenhouse, C F AU - Murphy, J R AU - Komisar, J AU - Thomas, N AU - Loyevsky, M AU - Birkett, A AU - Plowe, C V AU - Loucq, C AU - Edelman, R AU - Richie, T L AU - Seder, R A AU - Hoffman, S L AD - U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, MD 20910, USA. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Sanaria Inc., Rockville, MD 20850, USA. Protein Potential LLC, Rockville, MD 20850, USA. Howard Hughes Medical Institute, Baltimore, MD 21201, USA. Statistics Collaborative Inc., Washington, DC 20036, USA. U.S. Military Malaria Vaccine Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. PATH Malaria Vaccine Initiative, Bethesda, MD 20814, USA. Y1 - 2011/10/28/ PY - 2011 DA - 2011 Oct 28 SP - 475 EP - 480 PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 United States VL - 334 IS - 6055 SN - 0036-8075, 0036-8075 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - gamma -Interferon KW - Parasites KW - Human diseases KW - Hepatocytes KW - Bites KW - Disease control KW - Malaria KW - Infection KW - Public health KW - Lymphocytes T KW - Aquatic insects KW - Intravenous administration KW - Skin KW - Sporozoites KW - Plasmodium falciparum KW - CD8 antigen KW - Immunity KW - Immunization KW - Immunogenicity KW - Inoculation KW - Liver KW - Vaccines KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926892067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=Live+Attenuated+Malaria+Vaccine+Designed+to+Protect+Through+Hepatic+CD8%2B+T+Cell+Immunity&rft.au=Epstein%2C+JE%3BTewari%2C+K%3BLyke%2C+KE%3BSim%2C+BKL%3BBillingsley%2C+P+F%3BLaurens%2C+M+B%3BGunasekera%2C+A%3BChakravarty%2C+S%3BJames%2C+E+R%3BSedegah%2C+M%3BRichman%2C+A%3BVelmurugan%2C+S%3BReyes%2C+S%3BLi%2C+M%3BTucker%2C+K%3BAhumada%2C+A%3BRuben%2C+A+J%3BLi%2C+T%3BStafford%2C+R%3BEappen%2C+A+G%3BTamminga%2C+C%3BBennett%2C+J+W%3BOckenhouse%2C+C+F%3BMurphy%2C+J+R%3BKomisar%2C+J%3BThomas%2C+N%3BLoyevsky%2C+M%3BBirkett%2C+A%3BPlowe%2C+C+V%3BLoucq%2C+C%3BEdelman%2C+R%3BRichie%2C+T+L%3BSeder%2C+R+A%3BHoffman%2C+S+L&rft.aulast=Epstein&rft.aufirst=JE&rft.date=2011-10-28&rft.volume=334&rft.issue=6055&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Disease control; Malaria; Immunity; Vaccines; Aquatic insects; Immunization; Public health; gamma -Interferon; Intravenous administration; Skin; Bites; Hepatocytes; Sporozoites; CD8 antigen; Infection; Immunogenicity; Lymphocytes T; Liver; Inoculation; Plasmodium falciparum ER - TY - JOUR T1 - Enhanced neurodegeneration after a high dose of methamphetamine in adenosine A3 receptor null mutant mice AN - 902370017; 15763667 AB - Previous reports have indicated that adenosine A3 receptor (A3R) knockout mice are more sensitive to ischemic or hypoxic brain injury. The purpose of this study was to examine if suppression of A3R expression is associated with increase in sensitivity to injury induced by a high dose of methamphetamine (Meth). Adult male A3R null mutant (-/-) mice and their controls (+/+) were injected with four doses (2 h apart) of Meth (10 mg/kg) or saline. Animals were placed in a behavioral activity chamber, equipped with food and water, for 52 h starting from one day after injections. The first 4 h were used for studying exploratory behaviors, and the next 48 h were used to measure locomotor activity. High doses of Meth equally reduced the 4-h exploratory behavior in -/- and +/+ mice. Meth suppressed locomotor activity between 4 and 52 h in both groups, with a greater reduction being found in the -/- mice. Brain tissues were collected at 3 days after the Meth or saline injections. Meth treatment reduced striatal dopamine (DA) levels in both +/+ and -/- mice with an increase in 3,4-dihydroxyphenylacetic acid (DOPAC)/DA ratio being found only in -/- animals. Meth also significantly increased ionized calcium-binding adaptor molecule 1 (Iba-1) and cleaved caspase-3 level in striatum, as well as Iba-1 and TNF alpha mRNA expression in nigra in -/-, compared to +/+, mice. Previous studies have shown that pharmacological suppression of vesicular monoamine transport 2 (VMAT2) by reserpine enhanced Meth toxicity by increasing cytosolic DA and inflammation. A significant reduction in striatal VMAT2 expression was found in -/- mice compared to +/+ mice, suggesting that increase in sensitivity to Meth injury in -/- mice may be related to a reduction in VMAT2 expression in these mice. In conclusion, our data suggest that A3R -/- mice are more sensitive to high doses of Meth. JF - Neuroscience AU - Shen, H AU - Luo, Y AU - Yu, S-J AU - Wang, Y Y1 - 2011/10/27/ PY - 2011 DA - 2011 Oct 27 SP - 170 EP - 180 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 194 SN - 0306-4522, 0306-4522 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Adenosine A3 receptors KW - monoamines KW - Brain injury KW - Data processing KW - Exploratory behavior KW - Injuries KW - Reserpine KW - Food KW - Ischemia KW - Toxicity KW - Gene expression KW - Methamphetamine KW - Vesicular amine transporter KW - adaptor proteins KW - Dopamine KW - Locomotor activity KW - Neostriatum KW - Caspase-3 KW - Tumor necrosis factor- alpha KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902370017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Enhanced+neurodegeneration+after+a+high+dose+of+methamphetamine+in+adenosine+A3+receptor+null+mutant+mice&rft.au=Shen%2C+H%3BLuo%2C+Y%3BYu%2C+S-J%3BWang%2C+Y&rft.aulast=Shen&rft.aufirst=H&rft.date=2011-10-27&rft.volume=194&rft.issue=&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/10.1016%2Fj.neuroscience.2011.08.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-06-14 N1 - SubjectsTermNotLitGenreText - monoamines; Adenosine A3 receptors; Data processing; Brain injury; Reserpine; Injuries; Exploratory behavior; Food; Toxicity; Ischemia; Gene expression; adaptor proteins; Vesicular amine transporter; Methamphetamine; Dopamine; Locomotor activity; Neostriatum; Caspase-3; Tumor necrosis factor- alpha DO - http://dx.doi.org/10.1016/j.neuroscience.2011.08.013 ER - TY - JOUR T1 - Physical activity and breast cancer risk in Chinese women AN - 1008826759; 16451058 AB - Background: The influence of different types and intensities of physical activity on risk for breast cancer is unclear. Methods: In a prospective cohort of 73 049 Chinese women (40-70 years), who had worked outside the home, we studied breast cancer risk in relation to specific types of self-reported and work history-related physical activity, including adolescent and adult exercise and household activity and walking and cycling for transportation. Occupational sitting time and physical activity energy expenditure were assigned based on lifetime occupational histories. Results: In all, 717 incident breast cancer cases were diagnosed. Breast cancer risk was lower for women in the lowest quartile of average occupational sitting time and in the highest quartile of average occupational energy expenditure (adjusted hazard ratio (HR): 0.81 and 0.73, respectively, P less than or equal to 0.05). Adult exercise at or above the recommended level (8 metabolic equivalent (MET) h per week per year) was associated with lower risk (adjusted HR: 0.73, P<0.05) in post-menopausal women. Analysis of joint effects showed that having both an active job and exercise participation did not confer an additional benefit. Other common daily activities were not associated with lower risk.Interpretation:These findings suggest that both exercise and occupational activity are associated with lower breast cancer risk, which supports current health promotion campaigns promoting exercise. JF - British Journal of Cancer AU - Pronk, A AU - Ji, B-T AU - Shu, X-O AU - Chow, W-H AU - Xue, S AU - Yang, G AU - Li, H-L AU - Rothman, N AU - Gao, Y-T AU - Zheng, W AU - Matthews, C E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8100, MSC 7240, Bethesda, MD 20892, USA Y1 - 2011/10/25/ PY - 2011 DA - 2011 Oct 25 SP - 1443 EP - 1450 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 105 IS - 9 SN - 0007-0920, 0007-0920 KW - Physical Education Index; Health & Safety Science Abstracts; Risk Abstracts KW - Historical account KW - Home KW - Physical activity KW - Adolescence KW - Women KW - Breasts KW - Exercise KW - Adults KW - Cancer KW - Energy cost KW - households KW - Transportation KW - Households KW - Breast cancer KW - Females KW - health promotion KW - Sitting KW - physical activity KW - Adolescents KW - Health promotion KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1008826759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Physical+activity+and+breast+cancer+risk+in+Chinese+women&rft.au=Pronk%2C+A%3BJi%2C+B-T%3BShu%2C+X-O%3BChow%2C+W-H%3BXue%2C+S%3BYang%2C+G%3BLi%2C+H-L%3BRothman%2C+N%3BGao%2C+Y-T%3BZheng%2C+W%3BMatthews%2C+C+E&rft.aulast=Pronk&rft.aufirst=A&rft.date=2011-10-25&rft.volume=105&rft.issue=9&rft.spage=1443&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fbjc.2011.370 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2013-11-15 N1 - SubjectsTermNotLitGenreText - Energy cost; Home; Adolescence; Women; Breasts; Sitting; Adults; Exercise; Cancer; Historical account; households; Transportation; Households; Physical activity; Breast cancer; health promotion; Females; physical activity; Adolescents; Health promotion DO - http://dx.doi.org/10.1038/bjc.2011.370 ER - TY - JOUR T1 - XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes. AN - 900642120; 21967769 AB - Activation-induced deaminase (AID) deaminates cytosine to uracil in immunoglobulin genes. Uracils in DNA can be recognized by uracil DNA glycosylase and abasic endonuclease to produce single-strand breaks. The breaks are repaired either faithfully by DNA base excision repair (BER) or mutagenically to produce somatic hypermutation (SHM) and class switch recombination (CSR). To unravel the interplay between repair and mutagenesis, we decreased the level of x-ray cross-complementing 1 (XRCC1), a scaffold protein involved in BER. Mice heterozygous for XRCC1 showed a significant increase in the frequencies of SHM in Igh variable regions in Peyer's patch cells, and of double-strand breaks in the switch regions during CSR. Although the frequency of CSR was normal in Xrcc1(+/-) splenic B cells, the length of microhomology at the switch junctions decreased, suggesting that XRCC1 also participates in alternative nonhomologous end joining. Furthermore, Xrcc1(+/-) B cells had reduced Igh/c-myc translocations during CSR, supporting a role for XRCC1 in microhomology-mediated joining. Our results imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways. JF - The Journal of experimental medicine AU - Saribasak, Huseyin AU - Maul, Robert W AU - Cao, Zheng AU - McClure, Rhonda L AU - Yang, William AU - McNeill, Daniel R AU - Wilson, David M AU - Gearhart, Patricia J AD - Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.. Y1 - 2011/10/24/ PY - 2011 DA - 2011 Oct 24 SP - 2209 EP - 2216 VL - 208 IS - 11 KW - DNA-Binding Proteins KW - 0 KW - X-ray repair cross complementing protein 1 KW - Uracil-DNA Glycosidase KW - EC 3.2.2.- KW - AICDA (activation-induced cytidine deaminase) KW - EC 3.5.4.- KW - Cytidine Deaminase KW - EC 3.5.4.5 KW - Index Medicus KW - Cytidine Deaminase -- metabolism KW - Animals KW - DNA Repair KW - Uracil-DNA Glycosidase -- metabolism KW - Immunoglobulin Class Switching KW - Mice KW - DNA Breaks, Double-Stranded KW - Immunoglobulin Switch Region KW - Recombination, Genetic KW - Uracil-DNA Glycosidase -- genetics KW - Mice, Inbred C57BL KW - Cytidine Deaminase -- genetics KW - B-Lymphocytes -- physiology KW - Somatic Hypermutation, Immunoglobulin KW - Genes, Immunoglobulin KW - DNA-Binding Proteins -- genetics KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900642120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+experimental+medicine&rft.atitle=XRCC1+suppresses+somatic+hypermutation+and+promotes+alternative+nonhomologous+end+joining+in+Igh+genes.&rft.au=Saribasak%2C+Huseyin%3BMaul%2C+Robert+W%3BCao%2C+Zheng%3BMcClure%2C+Rhonda+L%3BYang%2C+William%3BMcNeill%2C+Daniel+R%3BWilson%2C+David+M%3BGearhart%2C+Patricia+J&rft.aulast=Saribasak&rft.aufirst=Huseyin&rft.date=2011-10-24&rft.volume=208&rft.issue=11&rft.spage=2209&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+experimental+medicine&rft.issn=1540-9538&rft_id=info:doi/10.1084%2Fjem.20111135 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-03 N1 - Date created - 2011-10-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 2001 Mar 15;29(6):E33 [11239010] Nucleic Acids Res. 2011 Oct;39(18):7992-8004 [21737425] Curr Biol. 2002 Oct 15;12(20):1748-55 [12401169] DNA Repair (Amst). 2003 Sep 18;2(9):955-69 [12967653] Cell. 2004 Aug 20;118(4):431-8 [15315756] Mol Cell. 2004 Oct 22;16(2):163-71 [15494304] Eur J Immunol. 1994 Nov;24(11):2918-21 [7957583] Dev Biol. 1999 Apr 15;208(2):513-29 [10191063] J Biol Chem. 2004 Dec 31;279(53):55117-26 [15498778] J Exp Med. 2005 Jan 17;201(2):189-94 [15657289] Cancer Res. 2005 May 15;65(10):4020-30 [15899791] Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8656-61 [15939880] J Immunol. 2006 Jan 1;176(1):365-71 [16365429] EMBO J. 2006 Feb 8;25(3):585-95 [16407970] Mol Cell Biol. 2006 May;26(10):3935-41 [16648486] DNA Repair (Amst). 2007 Feb 4;6(2):244-53 [17127106] Science. 2007 Jan 19;315(5810):377-81 [17170253] DNA Repair (Amst). 2007 Apr 1;6(4):544-59 [17112792] J Exp Med. 2007 Jul 9;204(7):1677-89 [17591858] J Exp Med. 2007 Jul 9;204(7):1717-27 [17606631] Nature. 2007 Sep 27;449(7161):478-82 [17713479] J Exp Med. 2007 Nov 26;204(12):3017-26 [18025127] Mol Cell. 2008 Feb 29;29(4):477-87 [18313385] J Exp Med. 2009 May 11;206(5):1047-56 [19364882] J Exp Med. 2009 Jun 8;206(6):1237-44 [19433618] J Exp Med. 2009 Aug 3;206(8):1817-30 [19596805] Nat Struct Mol Biol. 2009 Aug;16(8):808-13 [19633670] Cell Cycle. 2009 Oct 1;8(19):3097-101 [19738437] J Exp Med. 2010 Feb 15;207(2):417-27 [20142431] Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3034-9 [20133803] Nat Struct Mol Biol. 2010 Apr;17(4):410-6 [20208544] Adv Immunol. 2010;105:159-91 [20510733] PLoS One. 2010;5(6):e11182 [20567595] Nat Immunol. 2011 Jan;12(1):70-6 [21151102] Nat Struct Mol Biol. 2011 Jan;18(1):75-9 [21131982] Nature. 2002 Sep 5;419(6902):43-8 [12214226] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1084/jem.20111135 ER - TY - JOUR T1 - Predictive models for cytochrome p450 isozymes based on quantitative high throughput screening data. AN - 900635697; 21905670 AB - The human cytochrome P450 (CYP450) isozymes are the most important enzymes in the body to metabolize many endogenous and exogenous substances including environmental toxins and therapeutic drugs. Any unnecessary interactions between a small molecule and CYP450 isozymes may raise a potential to disarm the integrity of the protection. Accurately predicting the potential interactions between a small molecule and CYP450 isozymes is highly desirable for assessing the metabolic stability and toxicity of the molecule. The National Institutes of Health Chemical Genomics Center (NCGC) has screened a collection of over 17,000 compounds against the five major isozymes of CYP450 (1A2, 2C9, 2C19, 2D6, and 3A4) in a quantitative high throughput screening (qHTS) format. In this study, we developed support vector classification (SVC) models for these five isozymes using a set of customized generic atom types. The CYP450 data sets were randomly split into equal-sized training and test sets. The optimized SVC models exhibited high predictive power against the test sets for all five CYP450 isozymes with accuracies of 0.93, 0.89, 0.89, 0.85, and 0.87 for 1A2, 2C9, 2C19, 2D6, and 3A4, respectively, as measured by the area under the receiver operating characteristic (ROC) curves. The important atom types and features extracted from the five models are consistent with the structural preferences for different CYP450 substrates reported in the literature. We also identified novel features with significant discerning power to separate CYP450 actives from inactives. These models can be useful in prioritizing compounds in a drug discovery pipeline or recognizing the toxic potential of environmental chemicals. JF - Journal of chemical information and modeling AU - Sun, Hongmao AU - Veith, Henrike AU - Xia, Menghang AU - Austin, Christopher P AU - Huang, Ruili AD - National Institutes of Health, Chemical Genomics Center, NIH, Bethesda, Maryland 20892, United States. Y1 - 2011/10/24/ PY - 2011 DA - 2011 Oct 24 SP - 2474 EP - 2481 VL - 51 IS - 10 KW - Isoenzymes KW - 0 KW - Small Molecule Libraries KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - ROC Curve KW - Small Molecule Libraries -- metabolism KW - Humans KW - Protein Binding KW - Small Molecule Libraries -- chemistry KW - Isoenzymes -- metabolism KW - Support Vector Machine KW - High-Throughput Screening Assays -- methods KW - Cytochrome P-450 Enzyme System -- metabolism KW - Drug Evaluation, Preclinical -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900635697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chemical+information+and+modeling&rft.atitle=Predictive+models+for+cytochrome+p450+isozymes+based+on+quantitative+high+throughput+screening+data.&rft.au=Sun%2C+Hongmao%3BVeith%2C+Henrike%3BXia%2C+Menghang%3BAustin%2C+Christopher+P%3BHuang%2C+Ruili&rft.aulast=Sun&rft.aufirst=Hongmao&rft.date=2011-10-24&rft.volume=51&rft.issue=10&rft.spage=2474&rft.isbn=&rft.btitle=&rft.title=Journal+of+chemical+information+and+modeling&rft.issn=1549-960X&rft_id=info:doi/10.1021%2Fci200311w LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-02-14 N1 - Date created - 2011-10-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Top Med Chem. 2006;6(15):1609-18 [16918472] Curr Top Med Chem. 2006;6(15):1579-91 [16918470] Nat Biotechnol. 2006 Dec;24(12):1565-7 [17160063] J Biol Chem. 2007 May 11;282(19):14348-55 [17311915] J Mol Graph Model. 2008 Jun;26(8):1315-26 [18328754] Curr Med Chem. 2009;16(2):232-44 [19149574] Xenobiotica. 2009 Aug;39(8):625-35 [19514836] Curr Med Chem. 2009;16(24):3093-121 [19689286] Expert Opin Drug Metab Toxicol. 2009 Oct;5(10):1245-66 [19708826] Nat Biotechnol. 2009 Nov;27(11):1050-5 [19855396] Antioxid Redox Signal. 2010 Oct;13(8):1273-96 [20446763] J Med Chem. 2011 Mar 24;54(6):1539-54 [21344906] Future Med Chem. 2010 Sep;2(9):1451-68 [21103389] Br J Clin Pharmacol. 1999 Nov;48(5):716-27 [10594474] BMJ. 2000 Apr 8;320(7240):987-90 [10753155] Nature. 2003 Jul 24;424(6947):464-8 [12861225] J Chem Inf Comput Sci. 2004 Mar-Apr;44(2):748-57 [15032557] J Chem Inf Comput Sci. 2004 May-Jun;44(3):993-9 [15154767] Science. 2004 Jul 30;305(5684):683-6 [15256616] Clin Invest Med. 1989 Dec;12(6):357-62 [2612087] Biochemistry. 1994 May 31;33(21):6450-5 [8204577] Science. 1999 Oct 15;286(5439):487-91 [10521338] J Biomol Screen. 2005 Apr;10(3):197-205 [15809315] J Biol Chem. 2006 Mar 17;281(11):7614-22 [16352597] Expert Opin Drug Metab Toxicol. 2006 Aug;2(4):629-45 [16859410] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13682-7 [16954191] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ci200311w ER - TY - JOUR T1 - Concurrent vs sequential adjuvant chemotherapy and hormone therapy in breast cancer: a multicenter randomized phase III trial. AN - 900624951; 21921285 AB - The most appropriate timing of chemotherapy and hormone therapy administration is a critical issue in early breast cancer patients. The purpose of our study was to compare the efficacy of concurrent vs sequential administration of adjuvant chemotherapy and tamoxifen. Women with node-positive primary breast cancer were randomly assigned to receive tamoxifen (20 mg/d for 5 years) during (concurrent arm) or after (sequential arm) adjuvant chemotherapy. Chemotherapy consisted of alternating regimens of cyclophosphamide, epidoxorubicin, and 5-fluorouracil and cyclophosphamide, methotrexate, and 5-fluorouracil every 21 days for a total of 12 cycles. The primary endpoint was overall survival (OS), and secondary endpoints were toxic effects and disease-free survival (DFS). No provision for interim analyses was made in the original study protocol. Survival curves were estimated by the Kaplan-Meier method. Multivariable Cox regression models, adjusted for age, menopausal status, tumor stage, and lymph node and hormone receptor status, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). All statistical tests were two-sided. From 1985 to 1992, 431 patients were randomly assigned and studied according to the intention-to-treat principle. After a maximum of 15.4 years of follow-up (median 12.3 years), the estimated actuarial 10-year OS was equivalent for the two study arms (concurrent arm: 111 patients, 66%, 95% CI = 59% to 72%; sequential arm: 114 patients, 65%, 95% CI = 59% to 72%, P = .86). No differences in DFS and toxic effects were evident. Four interim analyses were performed, but no alpha error adjustment was necessary because of the largely negative results of this final analysis (sequential vs concurrent arm: HR of death = 1.06, 95% CI = 0.78 to 1.44, P = .76; HR of relapse = 1.16, 95% CI = 0.88 to 1.52, P = .36). No statistically significant differences in OS, DFS, and toxic effects between concurrent and sequential adjuvant chemo- and hormone therapies were observed. Our study does not support the superiority of one schedule of chemo- and hormone-therapy administration over the other. However, because of the limited statistical power of the study, these results must be considered with caution. JF - Journal of the National Cancer Institute AU - Bedognetti, Davide AU - Sertoli, Mario Roberto AU - Pronzato, Paolo AU - Del Mastro, Lucia AU - Venturini, Marco AU - Taveggia, Paola AU - Zanardi, Elisa AU - Siffredi, Guido AU - Pastorino, Simona AU - Queirolo, Paola AU - Gardin, Giovanni AU - Wang, Ena AU - Monzeglio, Clara AU - Boccardo, Francesco AU - Bruzzi, Paolo AD - Infectious Disease and Immunogenetics Section (IDIS), Department of Transfusion Medicine, Clinical Center, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. bedodav@yahoo.it Y1 - 2011/10/19/ PY - 2011 DA - 2011 Oct 19 SP - 1529 EP - 1539 VL - 103 IS - 20 KW - Antineoplastic Agents, Hormonal KW - 0 KW - Glucuronates KW - Receptors, Estrogen KW - Receptors, Progesterone KW - epidoxorubicin glucuronide KW - Tamoxifen KW - 094ZI81Y45 KW - Epirubicin KW - 3Z8479ZZ5X KW - Cyclophosphamide KW - 8N3DW7272P KW - Fluorouracil KW - U3P01618RT KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Disease-Free Survival KW - Humans KW - Mastectomy, Segmental KW - Neoplasms, Hormone-Dependent -- drug therapy KW - Tamoxifen -- administration & dosage KW - Italy KW - Multivariate Analysis KW - Fluorouracil -- administration & dosage KW - Receptors, Progesterone -- metabolism KW - Axilla KW - Adult KW - Treatment Outcome KW - Epirubicin -- analogs & derivatives KW - Epirubicin -- administration & dosage KW - Chemotherapy, Adjuvant KW - Drug Administration Schedule KW - Neoplasm Staging KW - Glucuronates -- administration & dosage KW - Prognosis KW - Receptors, Estrogen -- metabolism KW - Kaplan-Meier Estimate KW - Risk Factors KW - Confounding Factors (Epidemiology) KW - Follow-Up Studies KW - Middle Aged KW - Lymph Node Excision KW - Methotrexate -- administration & dosage KW - Female KW - Proportional Hazards Models KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - Antineoplastic Agents, Hormonal -- administration & dosage KW - Breast Neoplasms -- metabolism KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Breast Neoplasms -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900624951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Concurrent+vs+sequential+adjuvant+chemotherapy+and+hormone+therapy+in+breast+cancer%3A+a+multicenter+randomized+phase+III+trial.&rft.au=Bedognetti%2C+Davide%3BSertoli%2C+Mario+Roberto%3BPronzato%2C+Paolo%3BDel+Mastro%2C+Lucia%3BVenturini%2C+Marco%3BTaveggia%2C+Paola%3BZanardi%2C+Elisa%3BSiffredi%2C+Guido%3BPastorino%2C+Simona%3BQueirolo%2C+Paola%3BGardin%2C+Giovanni%3BWang%2C+Ena%3BMonzeglio%2C+Clara%3BBoccardo%2C+Francesco%3BBruzzi%2C+Paolo&rft.aulast=Bedognetti&rft.aufirst=Davide&rft.date=2011-10-19&rft.volume=103&rft.issue=20&rft.spage=1529&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/10.1093%2Fjnci%2Fdjr351 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-07 N1 - Date created - 2011-10-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Oncol. 2008 Feb;19(2):299-307 [17947224] Cancer Chemother Pharmacol. 2007 Mar;59(4):515-25 [16900372] J Natl Cancer Inst. 2010 Jan 6;102(1):14-25 [20007921] Lancet. 2009 Dec 19;374(9707):2055-63 [20004966] N Engl J Med. 2010 Jun 3;362(22):2053-65 [20519679] Breast Cancer. 2010 Oct;17(4):247-53 [19728030] N Engl J Med. 2010 Dec 2;363(23):2200-10 [21121833] Ann Oncol. 2002 Feb;13(2):273-9 [11886005] Ann Oncol. 2004 Jan;15(1):79-87 [14679124] Cancer Chemother Rep. 1966 Mar;50(3):163-70 [5910392] Cancer. 1981 Jan 1;47(1):207-14 [7459811] Breast Cancer Res Treat. 1981;1(2):121-3 [7348568] Cancer Res. 1983 Nov;43(11):5298-303 [6616464] J Clin Oncol. 1985 Dec;3(12):1672-7 [4067614] J Steroid Biochem. 1985 Dec;23(6B):1097-103 [3841574] N Engl J Med. 1988 Dec 29;319(26):1681-92 [3205265] J Clin Oncol. 1989 Jun;7(6):710-7 [2715802] J Clin Oncol. 1990 Jun;8(6):1005-18 [2189950] J Clin Oncol. 1991 Feb;9(2):286-94 [1988575] Cancer Res. 1994 Jan 15;54(2):441-7 [7903910] BMJ. 1995 Sep 16;311(7007):734-7 [7549691] J Clin Oncol. 1995 Nov;13(11):2712-21 [7595729] J Clin Oncol. 1996 Oct;14(10):2731-7 [8874334] Lancet. 1998 May 16;351(9114):1451-67 [9605801] Lancet. 2005 Apr 9-15;365(9467):1308 [15823379] Lancet. 2005 May 14-20;365(9472):1687-717 [15894097] Ann Oncol. 2005 Oct;16(10):1569-83 [16148022] J Natl Cancer Inst. 2005 Dec 7;97(23):1724-33 [16333028] Ann Oncol. 2006 Jan;17(1):65-73 [16361531] Ann Oncol. 2006 Oct;17(10):1475-7 [17005630] Cancer. 2008 Feb 1;112(3 Suppl):718-22 [18072257] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jnci/djr351 ER - TY - JOUR T1 - Surface-engineered magnetic nanoparticle platforms for cancer imaging and therapy. AN - 899142007; 21548618 AB - Enormous efforts have been made toward the translation of nanotechnology into medical practice, including cancer management. Generally the applications have fallen into two categories: diagnosis and therapy. Because the targets are often the same, the development of separate approaches can miss opportunities to improve efficiency and effectiveness. The unique physical properties of nanomaterials enable them to serve as the basis for superior imaging probes to locate and report cancerous lesions and as vehicles to deliver therapeutics preferentially to those lesions. These technologies for probes and vehicles have converged in the current efforts to develop nanotheranostics, nanoplatforms with both imaging and therapeutic functionalities. These new multimodal platforms are highly versatile and valuable components of the emerging trend toward personalized medicine, which emphasizes tailoring treatments to the biology of individual patients to optimize outcomes. The close coupling of imaging and treatment within a theranostic agent and the data about the evolving course of an illness that these agents provide can facilitate informed decisions about modifications to treatment. Magnetic nanoparticles, especially superparamagnetic iron oxide nanoparticles (IONPs), have long been studied as contrast agents for magnetic resonance imaging (MRI). Owing to recent progress in synthesis and surface modification, many new avenues have opened for this class of biomaterials. Such nanoparticles are not merely tiny magnetic crystals, but potential platforms with large surface-to-volume ratios. By taking advantage of the well-developed surface chemistry of these materials, researchers can load a wide range of functionalities, such as targeting, imaging and therapeutic features, onto their surfaces. This versatility makes magnetic nanoparticles excellent scaffolds for the construction of theranostic agents, and many efforts have been launched toward this goal. In this Account, we introduce the surface engineering techniques that we and others have developed, with an emphasis on how these techniques affect the role of nanoparticles as imaging or therapeutic agents. We and others have developed a set of chemical methods to prepare magnetic nanoparticles that possess accurate sizes, shapes, compositions, magnetizations, relaxivities, and surface charges. These features, in turn, can be harnessed to adjust the toxicity and stability of the nanoparticles and, further, to load functionalities, via various mechanisms, onto the nanoparticle surfaces. JF - Accounts of chemical research AU - Xie, Jin AU - Liu, Gang AU - Eden, Henry S AU - Ai, Hua AU - Chen, Xiaoyuan AD - National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892, USA. Y1 - 2011/10/18/ PY - 2011 DA - 2011 Oct 18 SP - 883 EP - 892 VL - 44 IS - 10 KW - Index Medicus KW - Animals KW - Humans KW - Surface Properties KW - Neoplasms -- diagnosis KW - Magnetic Phenomena KW - Nanoparticles -- therapeutic use KW - Molecular Imaging -- methods KW - Neoplasms -- therapy KW - Neoplasms -- metabolism KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899142007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Accounts+of+chemical+research&rft.atitle=Surface-engineered+magnetic+nanoparticle+platforms+for+cancer+imaging+and+therapy.&rft.au=Xie%2C+Jin%3BLiu%2C+Gang%3BEden%2C+Henry+S%3BAi%2C+Hua%3BChen%2C+Xiaoyuan&rft.aulast=Xie&rft.aufirst=Jin&rft.date=2011-10-18&rft.volume=44&rft.issue=10&rft.spage=883&rft.isbn=&rft.btitle=&rft.title=Accounts+of+chemical+research&rft.issn=1520-4898&rft_id=info:doi/10.1021%2Far200044b LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-31 N1 - Date created - 2011-10-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nano Lett. 2006 Apr;6(4):669-76 [16608262] Adv Drug Deliv Rev. 2011 Aug 14;63(9):772-88 [21554908] J Nucl Med. 2007 Jul;48(7):1162-71 [17574975] Angew Chem Int Ed Engl. 2007;46(28):5397-401 [17357103] J Magn Reson Imaging. 2007 Dec;26(6):1634-41 [17968941] Nat Protoc. 2008;3(1):89-96 [18193025] Acc Chem Res. 2008 Feb;41(2):179-89 [18281944] Nanomedicine (Lond). 2008 Apr;3(2):137-40 [18373419] Eur J Nucl Med Mol Imaging. 2008 Jun;35(6):1100-8 [18204838] J Am Chem Soc. 2008 Jun 18;130(24):7542-3 [18500805] J Nucl Med. 2008 Aug;49(8):1371-9 [18632815] Exp Biol Med (Maywood). 2009 Feb;234(2):123-31 [19064945] Biomaterials. 2009 May;30(15):2919-28 [19230966] Curr Med Chem. 2009;16(10):1278-94 [19355885] J Nanosci Nanotechnol. 2009 Jan;9(1):378-85 [19441322] Acc Chem Res. 2009 Aug 18;42(8):1097-107 [19476332] Angew Chem Int Ed Engl. 2009;48(41):7668-72 [19760685] Biomaterials. 2009 Dec;30(36):6912-9 [19773081] Chem Commun (Camb). 2010 Jan 21;46(3):433-5 [20066316] Biomaterials. 2010 Apr;31(11):3016-22 [20092887] J Nanosci Nanotechnol. 2010 Jan;10(1):540-8 [20352889] Contrast Media Mol Imaging. 2010 Mar-Apr;5(2):53-8 [20235146] Chem Rev. 2010 May 12;110(5):3087-111 [20225899] ACS Nano. 2010 Aug 24;4(8):4587-94 [20731441] Chem Commun (Camb). 2010 Sep 28;46(36):6684-6 [20730157] Adv Drug Deliv Rev. 2010 Aug 30;62(11):1064-79 [20691229] Biomaterials. 2011 Jan;32(2):528-37 [20869767] Mol Pharm. 2010 Dec 6;7(6):1899-912 [20822168] ACS Nano. 2010 Dec 28;4(12):7151-60 [21043459] J Nucl Med. 2011 Jan;52(1):140-6 [21149494] Nanoscale. 2011 Jan;3(1):142-53 [20938522] Mol Imaging Biol. 2011 Feb;13(1):87-93 [20440566] Mol Imaging. 2011 Feb;10(1):3-16 [21303611] Nano Lett. 2011 Feb 9;11(2):814-9 [21210706] Mol Biosyst. 2011 Apr;7(4):993-1003 [21308113] Mol Imaging. 2009 Mar-Apr;8(2):87-100 [19397854] J Mater Sci Mater Med. 2011 Mar;22(3):601-6 [21279674] Nano Lett. 2010 Nov 10;10(11):4607-13 [20939602] J Control Release. 2011 May 30;152(1):76-83 [21277920] Mol Imaging Biol. 2011 Aug;13(4):695-701 [20717735] Nat Med. 2007 Mar;13(3):372-7 [17322898] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ar200044b ER - TY - JOUR T1 - Polymeric lipid assemblies as novel theranostic tools. AN - 899133632; 21919465 AB - Polymerizable lipids have been used in research and medical applications such as membrane models, imaging platforms, drug delivery systems, vaccine carriers, biosensors, and coating materials. The polymerization of these lipid molecules forms a covalent bond between lipid moieties, which improves the noncovalent interactions that maintain the lipid lamellar phase architecture and increases the stability of the polymerized system. Because such lipid molecules form nanoassemblies with modifiable structures that acquire the stability of polymers following covalent bond formation, these lipids are of considerable interest in the emerging field of theranostics. In this Account, we summarize the biomedical applications of polymerizable lipids (primarily phospholipids) in the context of various nanoplatforms. We discuss stable nanoplatforms, which have been used in a variety of theranostics applications. In addition, we describe methods for assembling triggerable theranostics by combining appropriate nonpolymerizable lipids with polymerizable lipids. Polymeric lipids hold promise as nanotools in the field of medical imaging, targeting, and on-demand drug delivery. Because of their similarity to biological lipids, long-term toxicity issues from polymerizable lipid nanoplatforms are predicted to be minimal. Although the field of polymeric nanocapsules is still in development, intensive efforts are underway to produce systems which could be applied to disease diagnosis and treatment. We envision that nanoimaging platforms coupled with localized drug delivery technology will have a significant impact on cancer therapy and other related diseases. The existing wealth of clinical knowledge both in the photochemistry of imaging agents and/or drugs and modifications of these agents using light will prove valuable in the further development of polymeric theranostic lipid-based nanoparticles. JF - Accounts of chemical research AU - Puri, Anu AU - Blumenthal, Robert AD - CCR Nanobiology Program, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. Y1 - 2011/10/18/ PY - 2011 DA - 2011 Oct 18 SP - 1071 EP - 1079 VL - 44 IS - 10 KW - Drug Carriers KW - 0 KW - Lipids KW - Polymers KW - Index Medicus KW - Nanostructures -- therapeutic use KW - Drug Carriers -- therapeutic use KW - Animals KW - Polymerization KW - Nanostructures -- chemistry KW - Humans KW - Drug Carriers -- chemistry KW - Polymers -- therapeutic use KW - Lipids -- chemistry KW - Nanomedicine -- methods KW - Polymers -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899133632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Accounts+of+chemical+research&rft.atitle=Polymeric+lipid+assemblies+as+novel+theranostic+tools.&rft.au=Puri%2C+Anu%3BBlumenthal%2C+Robert&rft.aulast=Puri&rft.aufirst=Anu&rft.date=2011-10-18&rft.volume=44&rft.issue=10&rft.spage=1071&rft.isbn=&rft.btitle=&rft.title=Accounts+of+chemical+research&rft.issn=1520-4898&rft_id=info:doi/10.1021%2Far2001843 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-31 N1 - Date created - 2011-10-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: FEBS Lett. 2000 Feb 4;467(1):52-6 [10664455] J Liposome Res. 2011 Jun;21(2):141-50 [20560742] Chem Phys Lipids. 2001 Aug;112(2):99-108 [11551534] Adv Drug Deliv Rev. 2001 Dec 31;53(3):273-84 [11744172] J Control Release. 2002 May 17;81(1-2):7-23 [11992674] J Magn Reson Imaging. 2002 Oct;16(4):388-93 [12353254] Chem Phys Lipids. 2003 Jan;122(1-2):191-203 [12598052] Annu Rev Biophys Biomol Struct. 2004;33:269-95 [15139814] Phys Rev Lett. 2004 Sep 3;93(10):108105 [15447457] Science. 1972 Feb 18;175(4023):720-31 [4333397] Biochim Biophys Acta. 1980 Oct 16;602(1):57-69 [6893417] Biochem Biophys Res Commun. 1981 Jul 16;101(1):131-6 [7283995] Biochim Biophys Acta. 1982 May 7;687(2):165-9 [7093246] Biochim Biophys Acta. 1983 Jan 19;727(2):327-35 [6838876] Virology. 1983 Jun;127(2):361-73 [6868370] Exp Cell Res. 1983 Jul;146(2):422-7 [6873198] Biochim Biophys Acta. 1987 May 19;924(2):341-51 [3567222] J Pharm Sci. 1987 Jan;76(1):1-5 [3585714] Biochim Biophys Acta. 1987 Jun 12;900(1):1-9 [3593706] J Lipid Res. 1990 Aug;31(8):1522-5 [2280193] Adv Colloid Interface Sci. 1991 Jan;34:31-72 [2012684] Biochemistry. 1992 Jan 28;31(3):685-94 [1731924] Chem Phys Lipids. 1991 Oct;59(3):215-24 [1804565] J Med Chem. 1992 Nov 13;35(23):4501-2 [1447751] Science. 1993 Jul 30;261(5121):585-8 [8342021] Am J Respir Crit Care Med. 1995 Oct;152(4 Pt 2):S13-5 [7551405] Chem Biol. 1996 Feb;3(2):113-20 [8807836] Nature. 1997 Jun 5;387(6633):569-72 [9177342] Biosens Bioelectron. 2007 Feb 15;22(7):1205-17 [16934970] Biotechnol Lett. 2007 Nov;29(11):1637-44 [17636387] Bioorg Med Chem Lett. 2008 Jan 15;18(2):700-3 [18086524] Acc Chem Res. 2009 Aug 18;42(8):1016-25 [19453103] FEBS Lett. 2010 May 3;584(9):1653-8 [20036662] Annu Rev Biophys. 2010;39:207-26 [20192775] Biochim Biophys Acta. 2010 Jul;1798(7):1444-56 [20056106] Langmuir. 2010 Jun 15;26(12):10084-92 [20355709] Mol Membr Biol. 2010 Oct;27(7):364-81 [20939770] Biochim Biophys Acta. 2011 Jan;1808(1):117-26 [20691151] Annu Rev Biochem. 2000;69:531-69 [10966468] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ar2001843 ER - TY - JOUR T1 - cSSMD: assessing collective activity for addressing off-target effects in genome-scale RNA interference screens AN - 915486009; 16101719 AB - Motivation: Off-target activity commonly exists in RNA interference (RNAi) screens and often generates false positives. Existing analytic methods for addressing the off-target effects are demonstrably inadequate in RNAi confirmatory screens.Results: Here, we present an analytic method assessing the collective activity of multiple short interfering RNAs (siRNAs) targeting a gene. Using this method, we can not only reduce the impact of off-target activities, but also evaluate the specific effect of an siRNA, thus providing information about potential off-target effects. Using in-house RNAi screens, we demonstrate that our method obtains more reasonable and sensible results than current methods such as the redundant siRNA activity (RSA) method, the RNAi gene enrichment ranking (RIGER) method, the frequency approach and the t-test. JF - Bioinformatics AU - Zhang, Xiaohua Douglas AU - Santini, Francesca AU - Lacson, Raul AU - Marine, Shane D AU - Wu, Qian AU - Benetti, Luca AU - Yang, Ruojing AU - McCampbell, Alex AU - Berger, Joel P AU - Toolan, Dawn M AU - Stec, Erica M AU - Holder, Daniel J AU - Soper, Keith A AU - Heyse, Joseph F AU - Ferrer, Marc AD - super(1)Biometrics Research, Merck Research Laboratories, West Point, PA 19486, super(2)Automated Biotechnology, Merck Research Laboratories, North Wales, PA 19454, super(3)Biostatistics, University of Pennsylvania, Philadelphia, PA, super(4)Vaccine Manufacturing Sciences and Commercialization, Merck Manufacturing Division, West Point, PA 19486, super(5)Diabetes, Merck Research Laboratories, Rahway, NJ 07065, super(6)Neurology, Merck Research Laboratories, West Point, PA 19486, super(7)BARDS, Merck Research Laboratories, West Point, PA 19486 and super(8)Chemical Genomics Center, National Institutes of Health, Rockville, MD, USA, Y1 - 2011/10/15/ PY - 2011 DA - 2011 Oct 15 SP - 2775 EP - 2781 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 27 IS - 20 SN - 1367-4803, 1367-4803 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Data processing KW - siRNA KW - RNA-mediated interference KW - Bioinformatics KW - Internet KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/915486009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=cSSMD%3A+assessing+collective+activity+for+addressing+off-target+effects+in+genome-scale+RNA+interference+screens&rft.au=Zhang%2C+Xiaohua+Douglas%3BSantini%2C+Francesca%3BLacson%2C+Raul%3BMarine%2C+Shane+D%3BWu%2C+Qian%3BBenetti%2C+Luca%3BYang%2C+Ruojing%3BMcCampbell%2C+Alex%3BBerger%2C+Joel+P%3BToolan%2C+Dawn+M%3BStec%2C+Erica+M%3BHolder%2C+Daniel+J%3BSoper%2C+Keith+A%3BHeyse%2C+Joseph+F%3BFerrer%2C+Marc&rft.aulast=Zhang&rft.aufirst=Xiaohua&rft.date=2011-10-15&rft.volume=27&rft.issue=20&rft.spage=2775&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtr474 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Genomes; Data processing; siRNA; RNA-mediated interference; Bioinformatics; Internet DO - http://dx.doi.org/10.1093/bioinformatics/btr474 ER - TY - JOUR T1 - SPREAD: spatial phylogenetic reconstruction of evolutionary dynamics AN - 915484275; 16101727 AB - Summary: SPREAD is a user-friendly, cross-platform application to analyze and visualize Bayesian phylogeographic reconstructions incorporating spatial-temporal diffusion. The software maps phylogenies annotated with both discrete and continuous spatial information and can export high-dimensional posterior summaries to keyhole markup language (KML) for animation of the spatial diffusion through time in virtual globe software. In addition, SPREAD implements Bayes factor calculation to evaluate the support for hypotheses of historical diffusion among pairs of discrete locations based on Bayesian stochastic search variable selection estimates. SPREAD takes advantage of multicore architectures to process large joint posterior distributions of phylogenies and their spatial diffusion and produces visualizations as compelling and interpretable statistical summaries for the different spatial projections. JF - Bioinformatics AU - Bielejec, Filip AU - Rambaut, Andrew AU - Suchard, Marc A AU - Lemey, Philippe AD - super(1)Rega Institute for Medical Research, Clinical and Epidemiological Virology Section, Katholieke Universiteit Leuven, Leuven, Belgium, super(2)Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK, super(3)Fogarty International Center, National Institutes of Health, Bethesda, MD, super(4)Department of Biomathematics, super(5)Department of Biostatistics and super(6)Department of Human Genetics, University of California, Los Angeles, USA, Y1 - 2011/10/15/ PY - 2011 DA - 2011 Oct 15 SP - 2910 EP - 2912 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 27 IS - 20 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Phylogeny KW - Statistics KW - Bayesian analysis KW - spatial discrimination KW - Maps KW - Stochasticity KW - Joints KW - Computer programs KW - software KW - Diffusion KW - Language KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/915484275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=SPREAD%3A+spatial+phylogenetic+reconstruction+of+evolutionary+dynamics&rft.au=Bielejec%2C+Filip%3BRambaut%2C+Andrew%3BSuchard%2C+Marc+A%3BLemey%2C+Philippe&rft.aulast=Bielejec&rft.aufirst=Filip&rft.date=2011-10-15&rft.volume=27&rft.issue=20&rft.spage=2910&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtr481 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Phylogeny; Computer programs; software; Statistics; Bayesian analysis; spatial discrimination; Language; Diffusion; Bioinformatics; Maps; Stochasticity; Joints DO - http://dx.doi.org/10.1093/bioinformatics/btr481 ER - TY - JOUR T1 - Tuberculosis Biomarker and Surrogate Endpoint Research Roadmap AN - 900337527; 21737585 AB - The Centers for Disease Control and Prevention and National Institutes of Health convened a multidisciplinary meeting to discuss surrogate markers of treatment response in tuberculosis. The goals were to assess recent surrogate marker research and to provide specific recommendations for (1) the qualification and validation of biomarkers of treatment outcome; (2) the standardization of specimen and data collection for future clinical trials, including a minimum set of samples and collection time points; and (3) the creation ofa specimen repository to support biomarker testing. This article summarizes these recommendations and provides a roadmap for their implementation. JF - American Journal of Respiratory and Critical Care Medicine AU - Nahid, Payam AU - Saukkonen, Jussi AU - Mac Kenzie, William R AU - Johnson, John L AU - Phillips, Patrick P J AU - Andersen, Janet AU - Bliven-Sizemore, Erin AU - Belisle, John T AU - Boom, W Henry AU - Luetkemeyer, Annie AU - Campbell, Thomas B AU - Eisenach, Kathleen D AU - Hafner, Richard AU - Lennox, Jeffrey L AU - Makhene, Mamodikoe AU - Swindells, Susan AU - Villarino, M Elsa AU - Weiner, Marc AU - Benson, Constance AU - Burman, William Y1 - 2011/10/15/ PY - 2011 DA - 2011 Oct 15 SP - 972 EP - 9 CY - New York PB - American Thoracic Society VL - 184 IS - 8 SN - 1073449X KW - Medical Sciences--Respiratory Diseases KW - Antitubercular Agents KW - Biological Markers KW - Humans KW - Treatment Outcome KW - Biological Specimen Banks KW - Antitubercular Agents -- therapeutic use KW - Biological Markers -- metabolism KW - Tuberculosis -- metabolism KW - Biological Markers -- analysis KW - Tuberculosis -- drug therapy KW - Tuberculosis -- genetics KW - Specimen Handling -- standards KW - Tuberculosis -- immunology KW - Clinical Trials as Topic -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900337527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Tuberculosis+Biomarker+and+Surrogate+Endpoint+Research+Roadmap&rft.au=Nahid%2C+Payam%3BSaukkonen%2C+Jussi%3BMac+Kenzie%2C+William+R%3BJohnson%2C+John+L%3BPhillips%2C+Patrick+P+J%3BAndersen%2C+Janet%3BBliven-Sizemore%2C+Erin%3BBelisle%2C+John+T%3BBoom%2C+W+Henry%3BLuetkemeyer%2C+Annie%3BCampbell%2C+Thomas+B%3BEisenach%2C+Kathleen+D%3BHafner%2C+Richard%3BLennox%2C+Jeffrey+L%3BMakhene%2C+Mamodikoe%3BSwindells%2C+Susan%3BVillarino%2C+M+Elsa%3BWeiner%2C+Marc%3BBenson%2C+Constance%3BBurman%2C+William&rft.aulast=Nahid&rft.aufirst=Payam&rft.date=2011-10-15&rft.volume=184&rft.issue=8&rft.spage=972&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Oct 15, 2011 N1 - Last updated - 2017-01-07 ER - TY - JOUR T1 - Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates. AN - 898504800; 21998010 AB - To enable antibodies to function as cytotoxic anticancer agents, they are modified either via attachment to protein toxins or highly potent, low-molecular-weight drugs. Such molecules, termed immunotoxins and antibody-drug conjugates, respectively, represent a second revolution in antibody-mediated cancer therapy. Thus, highly toxic compounds are delivered to the interior of cancer cells based on antibody specificity for cell-surface target antigens. JF - Cancer research AU - FitzGerald, David J AU - Wayne, Alan S AU - Kreitman, Robert J AU - Pastan, Ira AD - Laboratory of Molecular Biology, National Cancer Institute, NIH, Bethesda, Maryland 20892-4264, USA. Y1 - 2011/10/15/ PY - 2011 DA - 2011 Oct 15 SP - 6300 EP - 6309 VL - 71 IS - 20 KW - Antigens, CD KW - 0 KW - Antigens, CD19 KW - Antigens, CD3 KW - Antigens, Differentiation, Myelomonocytic KW - Antineoplastic Agents KW - Bacterial Toxins KW - CD22 protein, human KW - CD33 protein, human KW - Cd33 protein, mouse KW - Exotoxins KW - IL3RA protein, human KW - Immunotoxins KW - Interleukin-3 Receptor alpha Subunit KW - Receptors, Interleukin-2 KW - SDC1 protein, human KW - Sialic Acid Binding Ig-like Lectin 2 KW - Sialic Acid Binding Ig-like Lectin 3 KW - Syndecan-1 KW - immunotoxin HA22 KW - Index Medicus KW - Animals KW - Antigens, CD19 -- immunology KW - Humans KW - Clinical Trials as Topic KW - Mice KW - Receptors, Interleukin-2 -- immunology KW - Antigens, CD3 -- immunology KW - Syndecan-1 -- immunology KW - Sialic Acid Binding Ig-like Lectin 2 -- immunology KW - Interleukin-3 Receptor alpha Subunit -- immunology KW - Bacterial Toxins -- therapeutic use KW - Antigens, Differentiation, Myelomonocytic -- immunology KW - Exotoxins -- therapeutic use KW - Antigens, CD -- immunology KW - Immunotoxins -- chemistry KW - Antineoplastic Agents -- immunology KW - Immunotoxins -- immunology KW - Hematologic Neoplasms -- drug therapy KW - Immunotoxins -- therapeutic use KW - Hematologic Neoplasms -- immunology KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/898504800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Treatment+of+hematologic+malignancies+with+immunotoxins+and+antibody-drug+conjugates.&rft.au=FitzGerald%2C+David+J%3BWayne%2C+Alan+S%3BKreitman%2C+Robert+J%3BPastan%2C+Ira&rft.aulast=FitzGerald&rft.aufirst=David&rft.date=2011-10-15&rft.volume=71&rft.issue=20&rft.spage=6300&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-11-1374 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-12 N1 - Date created - 2011-10-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Blood. 1999 Nov 15;94(10):3340-8 [10552943] J Clin Oncol. 2012 Aug 1;30(22):2776-82 [22753910] J Clin Oncol. 2000 Apr;18(8):1622-36 [10764422] Clin Cancer Res. 2000 Apr;6(4):1302-13 [10778955] Clin Cancer Res. 2000 Apr;6(4):1476-87 [10778980] Clin Cancer Res. 2001 Jun;7(6):1490-6 [11410481] N Engl J Med. 2001 Jul 26;345(4):241-7 [11474661] Clin Cancer Res. 2002 Apr;8(4):995-1002 [11948105] Blood. 1993 Nov 1;82(9):2624-33 [8219217] Cancer Immunol Immunother. 1994 Dec;39(6):367-74 [8001024] Blood. 1997 Sep 1;90(5):2020-6 [9292538] Bioconjug Chem. 1998 Nov-Dec;9(6):736-43 [9815167] Int J Cancer. 1999 Mar 31;81(1):148-55 [10077166] Leukemia. 2005 Feb;19(2):176-82 [15592433] Blood. 2005 Jul 15;106(2):454-7 [15811959] Blood. 2005 Aug 15;106(4):1183-8 [15886328] Semin Oncol. 2006 Feb;33(1 Suppl 3):S11-6 [16516670] Br J Haematol. 2006 Apr;133(2):141-51 [16611304] Cancer. 2006 May 15;106(10):2158-64 [16586495] J Pediatr Hematol Oncol. 2006 Apr;28(4):210-5 [16679917] Nat Rev Cancer. 2006 Jul;6(7):559-65 [16794638] Annu Rev Med. 2007;58:221-37 [17059365] Br J Haematol. 2007 Feb;136(3):439-47 [17233846] Leuk Lymphoma. 2007 Dec;48(12):2397-402 [17943599] Leuk Lymphoma. 2008 Mar;49(3):543-53 [18297533] J Clin Oncol. 2008 May 10;26(14):2390-3295 [18467731] Cancer Immunol Immunother. 2008 Aug;57(8):1225-39 [18256829] Cancer Res. 2008 Aug 1;68(15):6300-5 [18676854] Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11311-6 [18678888] Bioconjug Chem. 2008 Oct;19(10):1960-3 [18803412] Br J Haematol. 2008 Nov;143(4):541-7 [18759760] Clin Cancer Res. 2009 Feb 1;15(3):832-9 [19188153] Curr Drug Targets. 2009 Feb;10(2):104-9 [19199905] Cancer Res. 2009 Mar 15;69(6):2358-64 [19258515] Blood. 2009 Apr 16;113(16):3792-800 [18988862] Blood. 2009 May 14;113(20):4903-13 [19124831] Cancer Res. 2009 Jun 15;69(12):4941-4 [19509221] Clin Cancer Res. 2009 Jun 15;15(12):4028-37 [19509164] J Clin Oncol. 2009 Jun 20;27(18):2983-90 [19414673] Leuk Res. 2009 Sep;33(9):1233-42 [19327829] BMC Cancer. 2009;9:199 [19549303] Clin Cancer Res. 2009 Aug 15;15(16):5274-9 [19671873] J Pediatr Hematol Oncol. 2009 Dec;31(12):936-41 [19875969] MAbs. 2009 May-Jun;1(3):281-7 [20065645] MAbs. 2009 Nov-Dec;1(6):548-51 [20068397] Clin Cancer Res. 2010 Feb 1;16(3):888-97 [20086002] Cancer. 2010 Feb 15;116(4 Suppl):1126-33 [20127945] Clin Cancer Res. 2010 Mar 15;16(6):1894-903 [20215554] Blood. 2010 Apr 1;115(13):2586-91 [20103782] J Clin Oncol. 2010 Apr 10;28(11):1870-7 [20212249] J Clin Oncol. 2010 Apr 20;28(12):2085-93 [20308665] Nat Rev Immunol. 2010 May;10(5):317-27 [20414205] Methods Mol Biol. 2010;651:157-75 [20686966] Curr Opin Chem Biol. 2010 Aug;14(4):529-37 [20643572] Blood. 2010 Aug 19;116(7):1035-44 [20439624] N Engl J Med. 2010 Nov 4;363(19):1812-21 [21047225] Cancer Sci. 2012 May;103(5):933-8 [22335424] J Clin Oncol. 2012 Jun 20;30(18):2190-6 [22614995] Leukemia. 2000 Apr;14(4):576-85 [10764142] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-11-1374 ER - TY - JOUR T1 - Inactivation of CHEK1 and EI24 is associated with the development of invasive cervical carcinoma: clinical and prognostic implications. AN - 1022560018; 21154811 AB - To understand the importance of frequent deletion of chromosomal 11q23.3-24.3 region in cervical carcinogenesis, alterations (deletion/methylation/mutation/expression) of the candidate genes LOH11CR2A, EI24 and CHEK1 located in the region were analyzed in 29 cervical intraepithelial neoplasia (CIN), 112 cervical carcinoma (CACX) samples and two CACX cell lines. The deletion frequency of these genes was low in CIN than in CACX [CIN: CHEK1: 28%, EI24: 21%, LOH11CR2A: 15% and CACX: CHEK1: 51%, EI24: 41%, LOH11CR2A: 36%]. Similar trend was seen in promoter methylation of these genes [CIN: CHEK1: 10%, EI24: 3%, LOH11CR2A: 3% and CACX: CHEK1: 55%, EI24: 31%, LOH11CR2A: 14%]. Mutations of the genes are a rare event. Overall alterations (deletion and methylation) of CHEK1 and EI24 were associated with progression of CACX. Quantitative mRNA expression analysis showed reduced expression of the three genes in concordance to their molecular alterations. A shorter isoform of CHEK1 lacking exon 8, hence impaired in substrate binding capacity, was found in two samples. Immunohistochemical analysis showed nuclear expression of Chek1, p-Chek1 and Ei24 in tumor tissues, whereas the cell lines exhibited both nuclear and cytoplasmic expression of Chek1 and Ei24, as is also evident from Western blot analysis suggesting differential localization of the proteins. Alterations of CHEK1 and EI24 coupled with tumor stage and early sexual debut (≤ 19 years) predicted worst prognosis. Thus, our data suggest that inactivation of EI24 and CHEK1 through two independent mechanisms contributes to the development of CACX. Copyright © 2010 UICC. JF - International journal of cancer AU - Mazumder Indra, Dipanjana AU - Mitra, Sraboni AU - Singh, Ratnesh Kumar AU - Dutta, Sankhadeep AU - Roy, Anup AU - Mondal, Ranajit Kumar AU - Basu, Partha Sarathi AU - Roychoudhury, Susanta AU - Panda, Chinmay Kumar AD - Department of Oncogene Regulation, Chittaranjan National Cancer Institute, Kolkata, India. Y1 - 2011/10/15/ PY - 2011 DA - 2011 Oct 15 SP - 1859 EP - 1871 VL - 129 IS - 8 KW - Apoptosis Regulatory Proteins KW - 0 KW - EI24 protein, human KW - Neoplasm Proteins KW - Nuclear Proteins KW - VWA5A protein, human KW - Protein Kinases KW - EC 2.7.- KW - CHEK1 protein, human KW - EC 2.7.11.1 KW - Checkpoint Kinase 1 KW - Index Medicus KW - Gene Silencing KW - Humans KW - Prognosis KW - Disease Progression KW - Cell Line, Tumor KW - Recurrence KW - Chromosomes, Human, Pair 11 KW - Promoter Regions, Genetic KW - Cervical Intraepithelial Neoplasia -- genetics KW - DNA Methylation KW - Adult KW - Middle Aged KW - Mutation KW - Female KW - Nuclear Proteins -- genetics KW - Apoptosis Regulatory Proteins -- genetics KW - Uterine Cervical Neoplasms -- mortality KW - Neoplasm Proteins -- genetics KW - Protein Kinases -- genetics KW - Uterine Cervical Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1022560018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Inactivation+of+CHEK1+and+EI24+is+associated+with+the+development+of+invasive+cervical+carcinoma%3A+clinical+and+prognostic+implications.&rft.au=Mazumder+Indra%2C+Dipanjana%3BMitra%2C+Sraboni%3BSingh%2C+Ratnesh+Kumar%3BDutta%2C+Sankhadeep%3BRoy%2C+Anup%3BMondal%2C+Ranajit+Kumar%3BBasu%2C+Partha+Sarathi%3BRoychoudhury%2C+Susanta%3BPanda%2C+Chinmay+Kumar&rft.aulast=Mazumder+Indra&rft.aufirst=Dipanjana&rft.date=2011-10-15&rft.volume=129&rft.issue=8&rft.spage=1859&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.25849 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-09-13 N1 - Date created - 2012-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.25849 ER - TY - JOUR T1 - Active ERK1/2 protein interacts with the phosphorylated nuclear constitutive active/androstane receptor (CAR; NR1I3), repressing dephosphorylation and sequestering CAR in the cytoplasm. AN - 900633397; 21873423 AB - The nuclear constitutive active/androstane receptor (CAR) is inactivated and sequestered in the cytoplasm when Thr-38 is phosphorylated. Here, we have demonstrated that activated ERK1/2 interacts with phosphorylated CAR to repress dephosphorylation of Thr-38. The phosphorylation-dependent interaction between CAR and ERK1/2 was examined by co-immunoprecipitation experiments of ectopically expressed FLAG-tagged CAR T38A and CAR T38D mutants with endogenous phospho-ERK1/2 in Huh-7 cells. Phospho-ERK1/2 coprecipitated only the phosphorylation-mimicking CAR T38D mutant; this coprecipitation was mediated by the interaction with the xenochemical response signal peptide near the C terminus of CAR. This interaction increased after EGF treatment and decreased after treatment with the MEK inhibitor U0126 as well as after knockdown of MEK1/2 by shRNA in Huh-7 cells. The phosphorylation levels of Thr-38 of CAR decreased in U0126-treated Huh-7 cells. Thus, activated ERK1/2 interacts with CAR and represses dephosphorylation of Thr-38, providing a cell signal-regulated mechanism for CAR activation. JF - The Journal of biological chemistry AU - Osabe, Makoto AU - Negishi, Masahiko AD - Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2011/10/14/ PY - 2011 DA - 2011 Oct 14 SP - 35763 EP - 35769 VL - 286 IS - 41 KW - Butadienes KW - 0 KW - Enzyme Inhibitors KW - Nitriles KW - Protein Sorting Signals KW - Receptors, Cytoplasmic and Nuclear KW - U 0126 KW - constitutive androstane receptor KW - MAP2K2 protein, human KW - EC 2.7.1.- KW - MAPK1 protein, human KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 1 KW - Mitogen-Activated Protein Kinase 3 KW - MAP Kinase Kinase 1 KW - EC 2.7.12.2 KW - MAP Kinase Kinase 2 KW - MAP2K1 protein, human KW - Map2k1 protein, mouse KW - Map2k2 protein, mouse KW - Index Medicus KW - MAP Kinase Kinase 2 -- metabolism KW - Animals KW - Humans KW - Enzyme Activation -- physiology KW - MAP Kinase Kinase 2 -- genetics KW - Phosphorylation -- physiology KW - Enzyme Activation -- drug effects KW - Mice, Inbred C3H KW - MAP Kinase Kinase 1 -- metabolism KW - Protein Sorting Signals -- physiology KW - Protein Transport -- physiology KW - Amino Acid Substitution KW - Male KW - MAP Kinase Kinase 1 -- genetics KW - Nitriles -- pharmacology KW - Protein Transport -- drug effects KW - Mice KW - Mutation, Missense KW - Phosphorylation -- drug effects KW - Butadienes -- pharmacology KW - MAP Kinase Kinase 1 -- antagonists & inhibitors KW - MAP Kinase Kinase 2 -- antagonists & inhibitors KW - Enzyme Inhibitors -- pharmacology KW - Protein Structure, Tertiary KW - Cell Line KW - Mitogen-Activated Protein Kinase 3 -- metabolism KW - Mitogen-Activated Protein Kinase 1 -- genetics KW - Mitogen-Activated Protein Kinase 3 -- genetics KW - Cytoplasm -- genetics KW - Cytoplasm -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Mitogen-Activated Protein Kinase 1 -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900633397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Active+ERK1%2F2+protein+interacts+with+the+phosphorylated+nuclear+constitutive+active%2Fandrostane+receptor+%28CAR%3B+NR1I3%29%2C+repressing+dephosphorylation+and+sequestering+CAR+in+the+cytoplasm.&rft.au=Osabe%2C+Makoto%3BNegishi%2C+Masahiko&rft.aulast=Osabe&rft.aufirst=Makoto&rft.date=2011-10-14&rft.volume=286&rft.issue=41&rft.spage=35763&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M111.284596 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-12 N1 - Date created - 2011-10-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Pharmacol. 2007 May;71(5):1217-21 [17314319] Biochem J. 2007 Feb 1;401(3):735-41 [17032173] Biochem Biophys Res Commun. 2008 May 16;369(4):1027-33 [18331826] Trends Endocrinol Metab. 2009 Aug;20(6):273-9 [19595610] Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18831-6 [19850873] J Biol Chem. 2009 Dec 11;284(50):34785-92 [19858220] PLoS One. 2010;5(4):e10121 [20404936] Annu Rev Pharmacol Toxicol. 2001;41:123-43 [11264453] Mol Cell Biol. 2001 Apr;21(8):2838-46 [11283262] Mol Pharmacol. 2002 Jun;61(6):1284-8 [12021388] Mol Pharmacol. 2004 Jan;65(1):172-80 [14722249] Mol Cell Biol. 2004 Sep;24(18):7931-40 [15340055] Cancer Res. 2004 Oct 15;64(20):7197-200 [15492232] Mol Cell Biol. 1998 Oct;18(10):5652-8 [9742082] J Biol Chem. 1999 Mar 5;274(10):6043-6 [10037683] Mol Cell Biol. 1999 Sep;19(9):6318-22 [10454578] Mol Pharmacol. 2006 Dec;70(6):1925-34 [16988011] Drug Metab Pharmacokinet. 2008;23(1):8-13 [18305370] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M111.284596 ER - TY - JOUR T1 - Von Hippel-Lindau (VHL) Inactivation in Sporadic Clear Cell Renal Cancer: Associations with Germline VHL Polymorphisms and Etiologic Risk Factors AN - 920806902; 16207813 AB - Renal tumor heterogeneity studies have utilized the von Hippel-Lindau VHL gene to classify disease into molecularly defined subtypes to examine associations with etiologic risk factors and prognosis. The aim of this study was to provide a comprehensive analysis of VHL inactivation in clear cell renal tumors (ccRCC) and to evaluate relationships between VHL inactivation subgroups with renal cancer risk factors and VHL germline single nucleotide polymorphisms (SNPs). VHL genetic and epigenetic inactivation was examined among 507 sporadic RCC/470 ccRCC cases using endonuclease scanning and using bisulfite treatment and Sanger sequencing across 11 CpG sites within the VHL promoter. Case-only multivariate analyses were conducted to identify associations between alteration subtypes and risk factors. VHL inactivation, either through sequence alterations or promoter methylation in tumor DNA, was observed among 86.6% of ccRCC cases. Germline VHL SNPs and a haplotype were associated with promoter hypermethylation in tumor tissue (OR=6.10; 95% CI: 2.28-16.35, p=3.76E-4, p-global=8E-5). Risk of having genetic VHL inactivation was inversely associated with smoking due to a higher proportion of wild-type ccRCC tumors [former: OR=0.70 (0.20-1.31) and current: OR=0.56 (0.32-0.99); P-trend=0.04]. Alteration prevalence did not differ by histopathologic characteristics or occupational exposure to trichloroethylene. ccRCC cases with particular VHL germline polymorphisms were more likely to have VHL inactivation through promoter hypermethylation than through sequence alterations in tumor DNA, suggesting that the presence of these SNPs may represent an example of facilitated epigenetic variation (an inherited propensity towards epigenetic variation) in renal tissue. A proportion of tumors from current smokers lacked VHL alterations and may represent a biologically distinct clinical entity from inactivated cases. In a large case-series of 470 sporadic clear cell renal cancer (ccRCC) cases, we examined von Hippel-Lindau (VHL) inactivation as a biomarker of tumor heterogeneity. Germline alterations of the VHL gene were identified and have been found in most families with VHL disease, a hereditary syndrome associated with ccRCC. In sporadic disease, VHL alterations have been reported in up to 91% of cases. Here, we observed a high prevalence of VHL inactivation through both genetic and epigenetic mechanisms that were highly associated with ccRCC. VHL inactivation through promoter hypermethylation in tumors was associated with inherited polymorphisms selected to capture common variation across the VHL locus. A high-risk haplotype associated with promoter hypermethylation in tumor DNA was identified. These findings suggest that the presence of these polymorphisms and VHL promoter hypermethylation may represent an example of an inherited propensity toward epigenetic variation and potential silencing of the VHL gene in tumor tissue. This result could have translational implications, as individuals with the high-risk haplotype could be targeted for increased surveillance. Smokers had a higher prevalence of tumors without detectable VHL sequence alteration or epigenetic inactivation. Such tumors may be biologically distinct and have demonstrated a poorer prognosis compared to VHL inactivated cases. JF - PLoS Genetics AU - Moore, Lee E AU - Nickerson, Michael L AU - Brennan, Paul AU - Toro, Jorge R AU - Jaeger, Erich AU - Rinsky, Jessica AU - Han, Summer S AU - Zaridze, David AU - Matveev, Vsevolod AU - Janout, Vladimir AU - Kollarova, Hellena AU - Bencko, Vladimir AU - Navratilova, Marie AU - Szeszenia-Dabrowska, Neonilia AU - Mates, Dana AU - Schmidt, Laura S AU - Lenz, Petra AU - Karami, Sara AU - Linehan, WMarston AU - Merino, Maria AU - Chanock, Stephen AU - Boffetta, Paolo AU - Chow, Wong-Ho AU - Waldman, Frederic M AU - Rothman, Nathaniel AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2011/10/13/ PY - 2011 DA - 2011 Oct 13 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 United States VL - 7 IS - 0 SN - 1553-7390, 1553-7390 KW - Biochemistry Abstracts 2: Nucleic Acids; Risk Abstracts; Health & Safety Science Abstracts; Genetics Abstracts KW - inactivation KW - Translation KW - Gene polymorphism KW - Nucleotide sequence KW - Bisulfite KW - tumors KW - Neoplasia KW - Genetics KW - Promoters KW - Smoking KW - Haplotypes KW - Multivariate analysis KW - epigenetics KW - Risk factors KW - DNA methylation KW - Risk groups KW - Trichloroethylene KW - Endonuclease KW - Occupational exposure KW - Bioindicators KW - Prognosis KW - Clear cells KW - haplotypes KW - CpG islands KW - Tumors KW - VHL protein KW - biomarkers KW - Cancer KW - Scanning KW - Single-nucleotide polymorphism KW - DNA KW - Kidney KW - N 14820:DNA Metabolism & Structure KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920806902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Genetics&rft.atitle=Von+Hippel-Lindau+%28VHL%29+Inactivation+in+Sporadic+Clear+Cell+Renal+Cancer%3A+Associations+with+Germline+VHL+Polymorphisms+and+Etiologic+Risk+Factors&rft.au=Moore%2C+Lee+E%3BNickerson%2C+Michael+L%3BBrennan%2C+Paul%3BToro%2C+Jorge+R%3BJaeger%2C+Erich%3BRinsky%2C+Jessica%3BHan%2C+Summer+S%3BZaridze%2C+David%3BMatveev%2C+Vsevolod%3BJanout%2C+Vladimir%3BKollarova%2C+Hellena%3BBencko%2C+Vladimir%3BNavratilova%2C+Marie%3BSzeszenia-Dabrowska%2C+Neonilia%3BMates%2C+Dana%3BSchmidt%2C+Laura+S%3BLenz%2C+Petra%3BKarami%2C+Sara%3BLinehan%2C+WMarston%3BMerino%2C+Maria%3BChanock%2C+Stephen%3BBoffetta%2C+Paolo%3BChow%2C+Wong-Ho%3BWaldman%2C+Frederic+M%3BRothman%2C+Nathaniel&rft.aulast=Moore&rft.aufirst=Lee&rft.date=2011-10-13&rft.volume=7&rft.issue=0&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Genetics&rft.issn=15537390&rft_id=info:doi/10.1371%2Fjournal.pgen.1002312 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Translation; Nucleotide sequence; Gene polymorphism; Bisulfite; Neoplasia; Smoking; Promoters; Haplotypes; epigenetics; Multivariate analysis; Risk factors; DNA methylation; Risk groups; Trichloroethylene; Endonuclease; Occupational exposure; Clear cells; Prognosis; Tumors; CpG islands; VHL protein; biomarkers; Cancer; Scanning; Single-nucleotide polymorphism; Kidney; DNA; Bioindicators; inactivation; Genetics; tumors; haplotypes DO - http://dx.doi.org/10.1371/journal.pgen.1002312 ER - TY - CPAPER T1 - Finding genetic variants that underlie stuttering T2 - 61st Annual Meeting of the American Society of Human Genetics and the 12th International Congress of Human Genetics (ICHG 2011) AN - 1312981031; 6056289 JF - 61st Annual Meeting of the American Society of Human Genetics and the 12th International Congress of Human Genetics (ICHG 2011) AU - Drayna, D Y1 - 2011/10/11/ PY - 2011 DA - 2011 Oct 11 KW - Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312981031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Meeting+of+the+American+Society+of+Human+Genetics+and+the+12th+International+Congress+of+Human+Genetics+%28ICHG+2011%29&rft.atitle=Finding+genetic+variants+that+underlie+stuttering&rft.au=Drayna%2C+D&rft.aulast=Drayna&rft.aufirst=D&rft.date=2011-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Meeting+of+the+American+Society+of+Human+Genetics+and+the+12th+International+Congress+of+Human+Genetics+%28ICHG+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ichg2011.org/program_guide/files/assets/downloads/publication.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The function of genome-wide meiosisspecific epigenetic marks in recombination T2 - 61st Annual Meeting of the American Society of Human Genetics and the 12th International Congress of Human Genetics (ICHG 2011) AN - 1312909078; 6056174 JF - 61st Annual Meeting of the American Society of Human Genetics and the 12th International Congress of Human Genetics (ICHG 2011) AU - Camerini-Otero, R Y1 - 2011/10/11/ PY - 2011 DA - 2011 Oct 11 KW - Recombination KW - epigenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312909078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Annual+Meeting+of+the+American+Society+of+Human+Genetics+and+the+12th+International+Congress+of+Human+Genetics+%28ICHG+2011%29&rft.atitle=The+function+of+genome-wide+meiosisspecific+epigenetic+marks+in+recombination&rft.au=Camerini-Otero%2C+R&rft.aulast=Camerini-Otero&rft.aufirst=R&rft.date=2011-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Annual+Meeting+of+the+American+Society+of+Human+Genetics+and+the+12th+International+Congress+of+Human+Genetics+%28ICHG+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ichg2011.org/program_guide/files/assets/downloads/publication.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Simplified synthesis of isotopically labeled 5,5-dimethyl-pyrroline N-oxide. AN - 897812511; 21986521 AB - 5,5-Dimethylpyrroline N-oxide (15N) and 5,5-di(trideuteromethyl)pyrroline N-oxide were synthesized from the respective isotopically labeled 2-nitropropane analogs obtained from the reaction of sodium nitrate with 2-halopropanes. This facile, straightforward process allows synthesizing isotopically labeled DMPO analogs in a 4-step reaction without special equipment. JF - Molecules (Basel, Switzerland) AU - Leinisch, Fabian AU - Jiang, Jinjie AU - Deterding, Leesa J AU - Mason, Ronald P AD - Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA. leinischf@niehs.nih.gov Y1 - 2011/10/10/ PY - 2011 DA - 2011 Oct 10 SP - 8428 EP - 8436 VL - 16 IS - 10 KW - 5,5-dimethyl-pyrroline N-oxide KW - 0 KW - Carbon Isotopes KW - Cyclic N-Oxides KW - Nitrates KW - Nitrogen Isotopes KW - Nitroparaffins KW - Spin Labels KW - halopropane KW - 679-84-5 KW - sodium nitrate KW - 8M4L3H2ZVZ KW - 2-nitropropane KW - GKV234L2QH KW - Propane KW - T75W9911L6 KW - Index Medicus KW - Mass Spectrometry KW - Spin Trapping -- methods KW - Nitrogen Isotopes -- chemistry KW - Carbon Isotopes -- chemistry KW - Isotope Labeling KW - Nitrates -- chemistry KW - Propane -- analogs & derivatives KW - Cyclic N-Oxides -- chemical synthesis KW - Propane -- chemistry KW - Nitroparaffins -- chemistry KW - Cyclic N-Oxides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/897812511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecules+%28Basel%2C+Switzerland%29&rft.atitle=Simplified+synthesis+of+isotopically+labeled+5%2C5-dimethyl-pyrroline+N-oxide.&rft.au=Leinisch%2C+Fabian%3BJiang%2C+Jinjie%3BDeterding%2C+Leesa+J%3BMason%2C+Ronald+P&rft.aulast=Leinisch&rft.aufirst=Fabian&rft.date=2011-10-10&rft.volume=16&rft.issue=10&rft.spage=8428&rft.isbn=&rft.btitle=&rft.title=Molecules+%28Basel%2C+Switzerland%29&rft.issn=1420-3049&rft_id=info:doi/10.3390%2Fmolecules16108428 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-15 N1 - Date created - 2011-10-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: FEBS Lett. 2000 May 4;473(1):58-62 [10802059] Chem Biol Interact. 1989;70(1-2):167-72 [2544305] Free Radic Biol Med. 2009 Sep 1;47(5):568-76 [19482075] Free Radic Biol Med. 2005 Jan 1;38(1):125-35 [15589381] Mol Pharmacol. 1997 Dec;52(6):1081-6 [9415718] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3390/molecules16108428 ER - TY - JOUR T1 - Molecular targeting of CSN5 in human hepatocellular carcinoma: a mechanism of therapeutic response. AN - 896828061; 21499307 AB - Development of targeted therapy for hepatocellular carcinoma (HCC) remains a major challenge. We have recently identified an elevated expression of the fifth subunit of COP9 signalosome (CSN5) in early HCC as compared with dysplastic stage. In the present study, we explored the possibility of CSN5 being a potential therapeutic target for HCC. Our results show that CSN5 knockdown by small-interfering (si) RNA caused a strong induction of apoptosis and inhibition of cell-cycle progression in HCC cells in vitro. The down-regulation of CSN5 was sufficient to interfere with CSN function as evidenced by the accumulation of neddylated Cullin 1 and changes in the protein levels of CSN-controlled substrates SKP2, p53, p27 and nuclear factor-κB, albeit to a different degree depending on the HCC cell line, which could account for the CSN5 knockdown phenotype. The transcriptomic analysis of CSN5 knockdown signature showed that the anti-proliferative effect was driven by a common subset of molecular alterations including down-regulation of cyclin-dependent kinase 6 (CDK6) and integrin β1 (ITGB1), which were functionally interconnected with key oncogenic regulators MYC and TGFβ1 involved in the control of proliferation, apoptotic cell death and HCC progression. Consistent with microarray analysis, western blotting revealed that CSN5 depletion increased phosphorylation of Smad 2/3, key mediators of TGFβ1 signaling, decreased the protein levels of ITGB1, CDK6 and cyclin D1 and caused reduced expression of anti-apoptotic Bcl-2, while elevating the levels of pro-apoptotic Bak. A chemically modified variant of CSN5 siRNA was then selected for in vivo application based on the growth inhibitory effect and minimal induction of unwanted immune response. Systemic delivery of the CSN5 3/8 variant by stable-nucleic-acid-lipid particles significantly suppressed the tumor growth in Huh7-luc+ orthotopic xenograft model. Taken together, these results indicate that CSN5 has a pivotal role in HCC pathogenesis and maybe an attractive molecular target for systemic HCC therapy. JF - Oncogene AU - Lee, Y-H AU - Judge, A D AU - Seo, D AU - Kitade, M AU - Gómez-Quiroz, L E AU - Ishikawa, T AU - Andersen, J B AU - Kim, B-K AU - Marquardt, J U AU - Raggi, C AU - Avital, I AU - Conner, E A AU - MacLachlan, I AU - Factor, V M AU - Thorgeirsson, S S AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD, USA. Y1 - 2011/10/06/ PY - 2011 DA - 2011 Oct 06 SP - 4175 EP - 4184 VL - 30 IS - 40 KW - Intracellular Signaling Peptides and Proteins KW - 0 KW - RNA, Small Interfering KW - Peptide Hydrolases KW - EC 3.4.- KW - COPS5 protein, human KW - EC 3.4.-.- KW - Index Medicus KW - Gene Knockdown Techniques KW - Down-Regulation KW - Humans KW - RNA, Small Interfering -- genetics KW - Cell Line, Tumor KW - Cell Division KW - Intracellular Signaling Peptides and Proteins -- genetics KW - Liver Neoplasms -- pathology KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Intracellular Signaling Peptides and Proteins -- metabolism KW - Carcinoma, Hepatocellular -- drug therapy KW - Liver Neoplasms -- drug therapy KW - Peptide Hydrolases -- metabolism KW - Carcinoma, Hepatocellular -- pathology KW - Peptide Hydrolases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896828061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Molecular+targeting+of+CSN5+in+human+hepatocellular+carcinoma%3A+a+mechanism+of+therapeutic+response.&rft.au=Lee%2C+Y-H%3BJudge%2C+A+D%3BSeo%2C+D%3BKitade%2C+M%3BG%C3%B3mez-Quiroz%2C+L+E%3BIshikawa%2C+T%3BAndersen%2C+J+B%3BKim%2C+B-K%3BMarquardt%2C+J+U%3BRaggi%2C+C%3BAvital%2C+I%3BConner%2C+E+A%3BMacLachlan%2C+I%3BFactor%2C+V+M%3BThorgeirsson%2C+S+S&rft.aulast=Lee&rft.aufirst=Y-H&rft.date=2011-10-06&rft.volume=30&rft.issue=40&rft.spage=4175&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2011.126 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-22 N1 - Date created - 2011-10-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Biotechnol. 2005 Apr;23(4):457-62 [15778705] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Semin Liver Dis. 2005;25(2):212-25 [15918149] Hepatology. 2005 Jun;41(6):1349-56 [15880588] Nat Biotechnol. 2005 Aug;23(8):1002-7 [16041363] Cancer Lett. 2005 Nov 18;229(2):157-69 [16125305] Hepatology. 2005 Nov;42(5):1208-36 [16250051] Mol Ther. 2006 Mar;13(3):494-505 [16343994] Gene Ther. 2006 Mar;13(6):464-77 [16341059] Nat Genet. 2006 Apr;38(4):421-30 [16518402] Nature. 2006 May 4;441(7089):111-4 [16565705] FEBS Lett. 2006 Oct 30;580(25):5836-44 [17027978] Nat Chem Biol. 2006 Dec;2(12):711-9 [17108989] Gene Ther. 2006 Apr;13(7):583-4 [17526070] Cancer Res. 2008 Jan 15;68(2):506-15 [18199546] J Exp Med. 2008 Feb 18;205(2):465-77 [18268034] IDrugs. 2008 Apr;11(4):274-8 [18379962] N Engl J Med. 2008 Jul 24;359(4):378-90 [18650514] Hepatology. 2008 Oct;48(4):1312-27 [18821591] Cancer Res. 2008 Oct 15;68(20):8333-41 [18922905] Trends Biochem Sci. 2008 Dec;33(12):592-600 [18926707] Nat Rev Drug Discov. 2009 Feb;8(2):129-38 [19180106] J Clin Invest. 2009 Mar;119(3):661-73 [19229107] EMBO Rep. 2009 Apr;10(4):352-8 [19305390] Cancer Res. 2009 Apr 1;69(7):2775-82 [19276364] Genes Cells. 2009 Nov;14(11):1209-25 [19849719] Int J Cancer. 2010 Sep 1;127(6):1347-55 [20209494] Oncol Rep. 2004 Feb;11(2):277-84 [14719054] Am J Med. 2000 May;108(7):567-74 [10806286] J Hepatol. 2000 Dec;33(6):907-14 [11131452] Cancer Res. 2001 Mar 1;61(5):2129-37 [11280777] Nature. 2001 May 24;411(6836):494-8 [11373684] Nat Struct Biol. 2001 Sep;8(9):746-50 [11524674] Cell. 2001 Nov 16;107(4):465-76 [11719187] Clin Cancer Res. 2001 Dec;7(12):4130-5 [11751512] J Biol Chem. 2002 Jan 4;277(1):9-12 [11707426] Oncogene. 2002 Apr 11;21(16):2593-604 [11971194] Nat Genet. 2002 Aug;31(4):339-46 [12149612] Cancer Res. 2003 Jun 1;63(11):2977-81 [12782606] Hepatology. 2003 Jul;38(1):148-57 [12829997] Clin Cancer Res. 2003 Nov 15;9(15):5652-9 [14654548] Anticancer Res. 2003 Sep-Oct;23(5b):4121-5 [14666612] Nature. 2004 Mar 11;428(6979):190-3 [15014502] Mod Pathol. 2004 Jul;17(7):811-8 [15154004] Pathol Int. 2004 Sep;54(9):675-81 [15363035] Nature. 2004 Sep 16;431(7006):371-8 [15372045] Gastroenterology. 2004 Nov;127(5 Suppl 1):S51-5 [15508103] Nature. 1996 Oct 3;383(6599):453-7 [8837781] Nature. 1998 Feb 19;391(6669):806-11 [9486653] Mol Cell Biol. 1999 May;19(5):3654-63 [10207089] Mol Cell Biol. 1999 Jul;19(7):4672-83 [10373516] Pharm Res. 2005 Mar;22(3):362-72 [15835741] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/onc.2011.126 ER - TY - JOUR T1 - N-Alkyl-PEI-functionalized iron oxide nanoclusters for efficient siRNA delivery. AN - 894815598; 21861295 AB - Small-interfering RNA (siRNA) is an emerging class of therapeutics, which works by regulating the expression of a specific gene involved in disease progression. Despite the promises, effective transport of siRNA with minimal side effects remains a challenge. In this study, a nonviral nanoparticle gene carrier is developed and its efficiency for siRNA delivery and transfection is validated at both in vitro and in vivo levels. Such a nanocarrier, abbreviated as Alkyl-PEI2k-IO, was constructed with a core of iron oxide nanoparticles (IOs) and a shell of alkylated polyethyleneimine of 2000 Da [corrected] molecualr weight (Alkyl-PEI2k). It is found to be able to bind with siRNA, resulting in well-dispersed nanoparticles with a controlled clustering structure and narrow size distribution. Electrophoresis studies show that the Alkyl-PEI2k-IOs could retard siRNA completely at N:P ratios (i.e., PEI nitrogen to nucleic acid phosphate) above 10, protect siRNA from enzymatic degradation in serum, and release complexed siRNA efficiently in the presence of polyanionic heparin. The knockdown efficiency of the siRNA-loaded nanocarriers is assessed with 4T1 cells stably expressing luciferase (fluc-4T1) and further, with a fluc-4T1 xenograft model. Significant down-regulation of luciferase is observed, and unlike high-molecular-weight analogues, the Alkyl-PEI2k-coated IOs show good biocompatibility. In conclusion, Alkyl-PEI2k-IOs demonstrate highly efficient delivery of siRNA and an innocuous toxic profile, making it a potential carrier for gene therapy. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. JF - Small (Weinheim an der Bergstrasse, Germany) AU - Liu, Gang AU - Xie, Jin AU - Zhang, Fan AU - Wang, Zhiyong AU - Luo, Kui AU - Zhu, Lei AU - Quan, Qimeng AU - Niu, Gang AU - Lee, Seulki AU - Ai, Hua AU - Chen, Xiaoyuan AD - Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA. Y1 - 2011/10/04/ PY - 2011 DA - 2011 Oct 04 SP - 2742 EP - 2749 VL - 7 IS - 19 KW - Ferric Compounds KW - 0 KW - RNA, Small Interfering KW - ferric oxide KW - 1K09F3G675 KW - Polyethyleneimine KW - 9002-98-6 KW - Luciferases, Firefly KW - EC 1.13.12.7 KW - Index Medicus KW - Phantoms, Imaging KW - Animals KW - Luciferases, Firefly -- metabolism KW - Intracellular Space -- metabolism KW - Cell Death KW - Electrophoresis, Agar Gel KW - Mice KW - Cell Line, Tumor KW - Magnetic Resonance Spectroscopy KW - Gene Transfer Techniques KW - Polyethyleneimine -- analogs & derivatives KW - Ferric Compounds -- chemistry KW - Polyethyleneimine -- chemistry KW - RNA, Small Interfering -- metabolism KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/894815598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Small+%28Weinheim+an+der+Bergstrasse%2C+Germany%29&rft.atitle=N-Alkyl-PEI-functionalized+iron+oxide+nanoclusters+for+efficient+siRNA+delivery.&rft.au=Liu%2C+Gang%3BXie%2C+Jin%3BZhang%2C+Fan%3BWang%2C+Zhiyong%3BLuo%2C+Kui%3BZhu%2C+Lei%3BQuan%2C+Qimeng%3BNiu%2C+Gang%3BLee%2C+Seulki%3BAi%2C+Hua%3BChen%2C+Xiaoyuan&rft.aulast=Liu&rft.aufirst=Gang&rft.date=2011-10-04&rft.volume=7&rft.issue=19&rft.spage=2742&rft.isbn=&rft.btitle=&rft.title=Small+%28Weinheim+an+der+Bergstrasse%2C+Germany%29&rft.issn=1613-6829&rft_id=info:doi/10.1002%2Fsmll.201100825 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-23 N1 - Date created - 2011-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 1999 Oct 29;286(5441):950-2 [10542148] Acc Chem Res. 2008 Jun;41(6):749-59 [18507402] Nature. 2001 May 24;411(6836):494-8 [11373684] J Control Release. 2001 Jun 15;73(2-3):401-16 [11516515] Gene Ther. 2002 Jan;9(2):102-9 [11857068] Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14640-5 [12403826] Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9138-43 [12886020] Nature. 2004 Feb 26;427(6977):779-81 [14985734] Nature. 2004 Sep 16;431(7006):371-8 [15372045] Science. 1972 Mar 3;175(4025):949-55 [5061866] Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7297-301 [7638184] J Control Release. 1999 Aug 5;60(2-3):149-60 [10425321] Adv Genet. 2005;53:217-30 [16240995] Nat Med. 2006 Apr;12(4):401-9 [16582916] Nature. 2006 Apr 27;440(7088):1123 [16641981] J Control Release. 2006 May 15;112(2):257-70 [16574264] Cancer Gene Ther. 2006 Sep;13(9):819-29 [16424918] Nat Med. 2007 Mar;13(3):372-7 [17322898] Acc Chem Res. 2007 May;40(5):335-42 [17474708] Nat Rev Drug Discov. 2007 Jun;6(6):443-53 [17541417] Nat Rev Drug Discov. 2007 Jul;6(7):556-68 [17599085] J Gene Med. 2007 Oct;9(10):833-42 [17721874] J Drug Target. 2008 Feb;16(2):124-39 [18274933] Bioconjug Chem. 2008 Jul;19(7):1448-55 [18553894] Nat Rev Mol Cell Biol. 2009 Feb;10(2):126-39 [19165215] Clin Cancer Res. 2008 Oct 1;14(19):6137-45 [18829492] Biopolymers. 2008 Oct;89(10):881-8 [18521895] J Control Release. 2009 Feb 10;133(3):214-20 [18973779] Curr Med Chem. 2009;16(10):1278-94 [19355885] Int J Pharm. 2009 May 8;372(1-2):169-76 [19429277] J Nanosci Nanotechnol. 2009 Jan;9(1):378-85 [19441322] Mol Pharm. 2009 May-Jun;6(3):651-8 [19115957] Acc Chem Res. 2009 Aug 18;42(8):1097-107 [19476332] Chem Commun (Camb). 2010 Jan 21;46(3):433-5 [20066316] Small. 2010 Jan;6(2):239-46 [19924738] Biomaterials. 2010 Mar;31(7):1830-8 [19942284] Nat Mater. 2010 Mar;9(3):272-8 [20098433] Biomaterials. 2010 Apr;31(11):3016-22 [20092887] Curr Drug Targets. 2010 Mar;11(3):345-60 [20210759] Nature. 2010 Apr 15;464(7291):1067-70 [20305636] Contrast Media Mol Imaging. 2010 Mar-Apr;5(2):53-8 [20235146] Langmuir. 2010 May 18;26(10):7314-26 [20112951] Bioconjug Chem. 2010 May 19;21(5):836-43 [20438071] Bioconjug Chem. 2009 Mar 18;20(3):488-99 [19199781] Adv Mater. 2010 Jul 6;22(25):2729-42 [20473985] Expert Rev Mol Med. 2010;12:e26 [20716384] ACS Nano. 2010 Aug 24;4(8):4539-50 [20731437] Biomaterials. 2010 Nov;31(31):8032-42 [20673683] ACS Nano. 2010 Sep 28;4(9):5505-11 [20707386] Biomaterials. 2011 Jan;32(2):528-37 [20869767] Mol Pharm. 2010 Dec 6;7(6):1930-9 [20722417] Curr Drug Deliv. 2011 Jan;8(1):59-69 [21034421] Biomaterials. 2011 Mar;32(7):1890-905 [21167595] Erratum In: Small. 2011 Dec 2;7(23):3260 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/smll.201100825 ER - TY - CPAPER T1 - Para-aortic Nodal Clinical Target Volume Delineation in the Era of Particle Therapy T2 - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AN - 1313046628; 6068163 JF - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AU - Simone, C AU - O'Connell, J AU - Both, S AU - Mansueti, J AU - Christodouleas, J AU - Deville, C AU - McDonough, J AU - Vapiwala, N AU - Efstathiou, J AU - Bekelman, J Y1 - 2011/10/02/ PY - 2011 DA - 2011 Oct 02 KW - Particulates KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313046628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=Para-aortic+Nodal+Clinical+Target+Volume+Delineation+in+the+Era+of+Particle+Therapy&rft.au=Simone%2C+C%3BO%27Connell%2C+J%3BBoth%2C+S%3BMansueti%2C+J%3BChristodouleas%2C+J%3BDeville%2C+C%3BMcDonough%2C+J%3BVapiwala%2C+N%3BEfstathiou%2C+J%3BBekelman%2C+J&rft.aulast=Simone&rft.aufirst=C&rft.date=2011-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The Relationship of Post-Operative Breast Radiation Therapy to Physical Function T2 - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AN - 1313044395; 6067670 JF - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AU - Kesarwala, A AU - Pfalzer, L AU - O'Meara, W AU - Stout, N Y1 - 2011/10/02/ PY - 2011 DA - 2011 Oct 02 KW - Radiation therapy KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313044395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=The+Relationship+of+Post-Operative+Breast+Radiation+Therapy+to+Physical+Function&rft.au=Kesarwala%2C+A%3BPfalzer%2C+L%3BO%27Meara%2C+W%3BStout%2C+N&rft.aulast=Kesarwala&rft.aufirst=A&rft.date=2011-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Predictive Value of Tumor Recurrence Using Urinary Vascular Endothelial Growth Factor Levels in Patients Receiving Radiation Therapy for Glioblastoma T2 - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AN - 1313018164; 6066572 JF - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AU - Camphausen, K AU - Wang, M AU - Graves, C AU - Corn, B AU - Muanza, T AU - Howard, S AU - Mahadevan, A AU - Schultz, C AU - Haas, M AU - Mehta, M Y1 - 2011/10/02/ PY - 2011 DA - 2011 Oct 02 KW - Growth factors KW - Radiation therapy KW - Tumors KW - Urine KW - Glioblastoma KW - Vascular endothelial growth factor KW - Prediction KW - Therapy KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313018164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=Predictive+Value+of+Tumor+Recurrence+Using+Urinary+Vascular+Endothelial+Growth+Factor+Levels+in+Patients+Receiving+Radiation+Therapy+for+Glioblastoma&rft.au=Camphausen%2C+K%3BWang%2C+M%3BGraves%2C+C%3BCorn%2C+B%3BMuanza%2C+T%3BHoward%2C+S%3BMahadevan%2C+A%3BSchultz%2C+C%3BHaas%2C+M%3BMehta%2C+M&rft.aulast=Camphausen&rft.aufirst=K&rft.date=2011-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=&rft_id=info:doi/ L2 - https://www.astro.org/Meetings-and-Events/2011-Annual-Meeting/Meeting-Program/Schedule-of-Events.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Radiation Doses to the Esophagus from Radiotherapy Treatment for Breast Cancer during 1943-2001 T2 - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AN - 1313012159; 6067657 JF - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AU - Lamart, S AU - Morton, L AU - Simon, S AU - Curtis, R AU - Aleman, B AU - Smith, S AU - Weathers, R AU - Stovall, M Y1 - 2011/10/02/ PY - 2011 DA - 2011 Oct 02 KW - radiotherapy KW - Breast cancer KW - Radiation KW - Radiotherapy KW - Esophagus KW - Oesophagus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313012159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=Radiation+Doses+to+the+Esophagus+from+Radiotherapy+Treatment+for+Breast+Cancer+during+1943-2001&rft.au=Lamart%2C+S%3BMorton%2C+L%3BSimon%2C+S%3BCurtis%2C+R%3BAleman%2C+B%3BSmith%2C+S%3BWeathers%2C+R%3BStovall%2C+M&rft.aulast=Lamart&rft.aufirst=S&rft.date=2011-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Pre-clinical Evaluation of 177Lu-Labeled Trastuzumab Targeting HER2 for Radioimmunotherapeutic and Radioimmunodiagnostic Applications T2 - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AN - 1313001768; 6067315 JF - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AU - Ray, G AU - Baidoo, K AU - Keller, L AU - Milenic, D AU - Brechbiel, M Y1 - 2011/10/02/ PY - 2011 DA - 2011 Oct 02 KW - ErbB-2 protein KW - trastuzumab UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313001768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=Pre-clinical+Evaluation+of+177Lu-Labeled+Trastuzumab+Targeting+HER2+for+Radioimmunotherapeutic+and+Radioimmunodiagnostic+Applications&rft.au=Ray%2C+G%3BBaidoo%2C+K%3BKeller%2C+L%3BMilenic%2C+D%3BBrechbiel%2C+M&rft.aulast=Ray&rft.aufirst=G&rft.date=2011-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Radiation Therapy for Management of Patients with HTLV-1-associated Adult T-cell Leukemia/Lymphoma T2 - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AN - 1312958627; 6067897 JF - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AU - Simone, C AU - Stewart, D AU - Lita, E AU - Kreitman, R AU - Conlon, K AU - Janik, J AU - Morris, J AU - Kaushal, A Y1 - 2011/10/02/ PY - 2011 DA - 2011 Oct 02 KW - lymphoma KW - Radiation therapy KW - Leukemia KW - Lymphoma KW - Lymphocytes T KW - Therapy KW - Human T-lymphotropic virus KW - Human T-lymphotropic virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312958627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=Radiation+Therapy+for+Management+of+Patients+with+HTLV-1-associated+Adult+T-cell+Leukemia%2FLymphoma&rft.au=Simone%2C+C%3BStewart%2C+D%3BLita%2C+E%3BKreitman%2C+R%3BConlon%2C+K%3BJanik%2C+J%3BMorris%2C+J%3BKaushal%2C+A&rft.aulast=Simone&rft.aufirst=C&rft.date=2011-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Lack of Radiation-Induced Pulmonary Toxicity 25 years after Treatment with Breast Conservation Therapy or Mastectomy for Early-stage Breast Cancer: Results from the NCI Randomized Trial T2 - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AN - 1312955230; 6066348 JF - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AU - Simone, N AU - Simone, B AU - Simone, C AU - Dan, T AU - Ly, D. AU - Lita, E AU - Smith, S AU - Levine, S AU - Folio, L Y1 - 2011/10/02/ PY - 2011 DA - 2011 Oct 02 KW - Toxicity KW - Conservation KW - Breast cancer KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312955230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=Lack+of+Radiation-Induced+Pulmonary+Toxicity+25+years+after+Treatment+with+Breast+Conservation+Therapy+or+Mastectomy+for+Early-stage+Breast+Cancer%3A+Results+from+the+NCI+Randomized+Trial&rft.au=Simone%2C+N%3BSimone%2C+B%3BSimone%2C+C%3BDan%2C+T%3BLy%2C+D.%3BLita%2C+E%3BSmith%2C+S%3BLevine%2C+S%3BFolio%2C+L&rft.aulast=Simone&rft.aufirst=N&rft.date=2011-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=&rft_id=info:doi/ L2 - https://www.astro.org/Meetings-and-Events/2011-Annual-Meeting/Meeting-Program/Schedule-of-Events.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Intrarectal Amifostine Suspension During External Beam Radiotherapy For Prostate Cancer May Protect Against Long Term Toxicity T2 - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AN - 1312906999; 6068143 JF - 53rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology AU - Ko, C. AU - Menard, C AU - Ning, H AU - Lita, E AU - Smith, S AU - Pinto, P AU - Singh, A AU - Coleman, C AU - Camphausen, K AU - Kaushal, A Y1 - 2011/10/02/ PY - 2011 DA - 2011 Oct 02 KW - Toxicity KW - prostate cancer KW - radiotherapy KW - Amifostine KW - Radiotherapy KW - Prostate cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312906999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=Intrarectal+Amifostine+Suspension+During+External+Beam+Radiotherapy+For+Prostate+Cancer+May+Protect+Against+Long+Term+Toxicity&rft.au=Ko%2C+C.%3BMenard%2C+C%3BNing%2C+H%3BLita%2C+E%3BSmith%2C+S%3BPinto%2C+P%3BSingh%2C+A%3BColeman%2C+C%3BCamphausen%2C+K%3BKaushal%2C+A&rft.aulast=Ko&rft.aufirst=C.&rft.date=2011-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Direct and Mediated Effects of Two Theoretically Based Interventions to Increase Consumption of Fruits and Vegetables in the Healthy Body Healthy Spirit Trial AN - 927830337; 201120675 AB - This study tested the effects of two theory-based interventions to increase fruit and vegetable intake. Hypothesized intervention mediators included self-efficacy (SE), social support (SS), autonomous motivation (AM), and controlled motivation (CM). At baseline, 1,021 African American adults were recruited from 16 churches randomized to one comparison and two intervention groups: Group 1 (standard educational materials), Group 2 (culturally targeted materials), and Group 3 (culturally targeted materials and telephone-based motivational interviewing). A well-fitted model based on structural equation modeling-X2(df = 541, N = 353, 325) = 864.28, p < .001, normed fit index = .96, nonnormed fit index = .98, comparative fit index = .98, root mean square error of approximation = .042-demonstrated that AM was both a significant mediator and moderator. In the subgroup with low baseline AM, AM mediated 17% of the effect of the Group 3 intervention on fruit and vegetable intake. Conversely, SS, SE, and CM were not significant mediators. Implications related to theory and intervention development are discussed. [Reprinted by permission of Sage Publications Inc., copyright, the Society for Public Health Education.] JF - Health Education & Behavior AU - Shaikh, Abdul R AU - Vinokur, Amiram D AU - Yaroch, Amy L AU - Williams, Geoffrey C AU - Resnicow, Ken AD - National Cancer Institute, Bethesda, MD, USA shaikhab@mail.nih.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 492 EP - 501 PB - Sage Publications, Thousand Oaks CA VL - 38 IS - 5 SN - 1090-1981, 1090-1981 KW - African Americans fruit and vegetable consumption mediation analysis interaction effects latent variable structural equation modeling KW - Healthy food KW - Telephone services KW - Motivation KW - Interventions KW - Christian churches KW - Moderators KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/927830337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education+%26+Behavior&rft.atitle=Direct+and+Mediated+Effects+of+Two+Theoretically+Based+Interventions+to+Increase+Consumption+of+Fruits+and+Vegetables+in+the+Healthy+Body+Healthy+Spirit+Trial&rft.au=Shaikh%2C+Abdul+R%3BVinokur%2C+Amiram+D%3BYaroch%2C+Amy+L%3BWilliams%2C+Geoffrey+C%3BResnicow%2C+Ken&rft.aulast=Shaikh&rft.aufirst=Abdul&rft.date=2011-10-01&rft.volume=38&rft.issue=5&rft.spage=492&rft.isbn=&rft.btitle=&rft.title=Health+Education+%26+Behavior&rft.issn=10901981&rft_id=info:doi/10.1177%2F1090198110384468 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-11-02 N1 - Number of references - 43 N1 - Last updated - 2016-09-27 N1 - CODEN - HEDBFS N1 - SubjectsTermNotLitGenreText - Healthy food; Interventions; Motivation; Telephone services; Moderators; Christian churches DO - http://dx.doi.org/10.1177/1090198110384468 ER - TY - JOUR T1 - Internal standard-based analysis of microarray data2-Analysis of functional associations between HVE-genes AN - 918063150; 16141752 AB - In this work we apply the Internal Standard-based analytical approach that we described in an earlier communication and here we demonstrate experimental results on functional associations among the hypervariably-expressed genes (HVE-genes). Our working assumption was that those genetic components, which initiate the disease, involve HVE-genes for which the level of expression is undistinguishable among healthy individuals and individuals with pathology. We show that analysis of the functional associations of the HVE-genes is indeed suitable to revealing disease-specific differences. We show also that another possible exploit of HVE-genes for characterization of pathological alterations is by using multivariate classification methods. This in turn offers important clues on naturally occurring dynamic processes in the organism and is further used for dynamic discrimination of groups of compared samples. We conclude that our approach can uncover principally new collective differences that cannot be discerned by individual gene analysis. JF - Nucleic Acids Research AU - Dozmorov, Igor M AU - Jarvis, James AU - Saban, Ricardo AU - Benbrook, Doris M AU - Wakeland, Edward AU - Aksentijevich, Ivona AU - Ryan, John AU - Chiorazzi, Nicholas AU - Guthridge, Joel M AU - Drewe, Elizabeth AU - Tighe, Patrick J AU - Centola, Michael AU - Lefkovits, Ivan AD - super(1)Oklahoma Medical Research Foundation, super(2)Oklahoma University Health Science Center HSC, Oklahoma City, OK 73104, super(3)The University of Texas Southwestern Medical Center, Dallas, Texas 75390, super(4)National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, super(5)The Feinstein Institute for Medical Research, super(6)The Departments of Medicine and of Cell Biology, North Shore University Hospital, super(7)Albert Einstein College of Medicine, Manhasset, NY, USA, super(8)University of Nottingham, Nottingham, UK and super(9)Department of Biomedicine, University Clinics Basel, Vesalianum, Vesalgasse 1, CH-4051 Basel, Switzerland, igor-dozmorov@omrf.org Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 7881 EP - 7899 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 39 IS - 18 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Classification KW - Communication KW - G 07880:Human Genetics KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918063150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Internal+standard-based+analysis+of+microarray+data2-Analysis+of+functional+associations+between+HVE-genes&rft.au=Dozmorov%2C+Igor+M%3BJarvis%2C+James%3BSaban%2C+Ricardo%3BBenbrook%2C+Doris+M%3BWakeland%2C+Edward%3BAksentijevich%2C+Ivona%3BRyan%2C+John%3BChiorazzi%2C+Nicholas%3BGuthridge%2C+Joel+M%3BDrewe%2C+Elizabeth%3BTighe%2C+Patrick+J%3BCentola%2C+Michael%3BLefkovits%2C+Ivan&rft.aulast=Dozmorov&rft.aufirst=Igor&rft.date=2011-10-01&rft.volume=39&rft.issue=18&rft.spage=7881&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkr503 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2013-04-05 N1 - SubjectsTermNotLitGenreText - Classification; Communication DO - http://dx.doi.org/10.1093/nar/gkr503 ER - TY - JOUR T1 - Use of Surveillance, Epidemiology, and End Results-Medicare Data to Conduct Case-Control Studies of Cancer Among the US Elderly AN - 918052167; 16099534 AB - Cancer is an important cause of morbidity in the elderly, and many medical conditions and treatments influence cancer risk. The Surveillance, Epidemiology, and End Results (SEER)-Medicare database can be used to conduct population-based case-control studies that elucidate the etiology of cancer among the US elderly. SEER-Medicare links data on malignancies ascertained through SEER cancer registries to claims from Medicare, the US government insurance program for people over age 65 years. Under one approach described herein, elderly cancer cases are ascertained from SEER data (1987-2005). Matched controls are selected from a 5% random sample of Medicare beneficiaries. Risk factors of interest, including medical conditions and procedures, are identified by using linked Medicare claims. Strengths of this design include the ready availability of data, representative sampling from the US elderly population, and large sample size (e.g., under one scenario: 1,176,950 cases, including 221,389 prostate cancers, 185,853 lung cancers, 138,041 breast cancers, and 124,442 colorectal cancers; and 100,000 control subjects). Limitations reflect challenges in exposure assessment related to Medicare claims: restricted range of evaluable risk factors, short time before diagnosis/selection for ascertainment, and inaccuracies in claims. With awareness of limitations, investigators have in SEER-Medicare data a valuable resource for epidemiologic research on cancer etiology. JF - American Journal of Epidemiology AU - Engels, Eric A AU - Pfeiffer, Ruth M AU - Ricker, Winnie AU - Wheeler, William AU - Parsons, Ruth AU - Warren, Joan L Y1 - 2011/10/01/ PY - 2011 DA - 2011 Oct 01 SP - 860 EP - 870 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 174 IS - 7 SN - 0002-9262, 0002-9262 KW - Health & Safety Science Abstracts; Risk Abstracts KW - USA KW - Etiology KW - Epidemiology KW - colorectal carcinoma KW - Risk factors KW - Elderly KW - Breast cancer KW - elderly KW - prostate cancer KW - Morbidity KW - Lung cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918052167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Use+of+Surveillance%2C+Epidemiology%2C+and+End+Results-Medicare+Data+to+Conduct+Case-Control+Studies+of+Cancer+Among+the+US+Elderly&rft.au=Engels%2C+Eric+A%3BPfeiffer%2C+Ruth+M%3BRicker%2C+Winnie%3BWheeler%2C+William%3BParsons%2C+Ruth%3BWarren%2C+Joan+L&rft.aulast=Engels&rft.aufirst=Eric&rft.date=2011-10-01&rft.volume=174&rft.issue=7&rft.spage=860&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwr146 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - Etiology; Epidemiology; colorectal carcinoma; Risk factors; Elderly; Breast cancer; prostate cancer; elderly; Morbidity; Lung cancer; USA DO - http://dx.doi.org/10.1093/aje/kwr146 ER - TY - JOUR T1 - RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors. AN - 916852880; 21834757 AB - In an effort to develop strategies that improve the efficacy of existing anticancer agents, we have conducted a siRNA-based RNAi screen to identify genes that, when targeted by siRNA, improve the activity of the topoisomerase I (Top1) poison camptothecin (CPT). Screening was conducted using a set of siRNAs corresponding to over 400 apoptosisrelated genes in MDA-MB-231 breast cancer cells. During the course of these studies, we identified the silencing of MAP3K7 as a significant enhancer of CPT activity. Follow-up analysis of caspase activity and caspase-dependent phosphorylation of histone H2AX demonstrated that the silencing of MAP3K7 enhanced CPT-associated apoptosis. Silencing MAP3K7 also sensitized cells to additional compounds, including CPT clinical analogs. This activity was not restricted to MDA-MB-231 cells, as the silencing of MAP3K7 also sensitized the breast cancer cell line MDA-MB-468 and HCT-116 colon cancer cells. However, MAP3K7 silencing did not affect compound activity in the comparatively normal mammary epithelial cell line MCF10A, as well as some additional tumorigenic lines. MAP3K7 encodes the TAK1 kinase, an enzyme that is central to the regulation of many processes associated with the growth of cancer cells (e.g. NF- κB, JNK, and p38 signaling). An analysis of TAK1 signaling pathway members revealed that the silencing of TAB2 also sensitizes MDA-MB-231 and HCT-116 cells towards CPT. These findings may offer avenues towards lowering the effective doses of Top1 inhibitors in cancer cells and, in doing so, broaden their application. JF - Current cancer drug targets AU - Martin, S E AU - Wu, Z-H AU - Gehlhaus, K AU - Jones, T L AU - Zhang, Y-W AU - Guha, R AU - Miyamoto, S AU - Pommier, Y AU - Caplen, N J AD - Gene Silencing Section, Genetics Branch, CCR, NCI, NIH, Bethesda, MD 20892, USA. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 976 EP - 986 VL - 11 IS - 8 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - Neoplasm Proteins KW - RNA, Small Interfering KW - TAB2 protein, human KW - Topoisomerase Inhibitors KW - MAP Kinase Kinase Kinases KW - EC 2.7.11.25 KW - MAP kinase kinase kinase 7 KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - Adaptor Proteins, Signal Transducing -- metabolism KW - MAP Kinase Signaling System KW - Gene Transfer Techniques KW - Camptothecin -- pharmacology KW - Humans KW - Apoptosis -- drug effects KW - Adaptor Proteins, Signal Transducing -- genetics KW - Genetic Therapy KW - Cell Line, Tumor KW - Adaptor Proteins, Signal Transducing -- antagonists & inhibitors KW - Female KW - Breast Neoplasms -- drug therapy KW - Neoplasm Proteins -- antagonists & inhibitors KW - MAP Kinase Kinase Kinases -- genetics KW - Breast Neoplasms -- metabolism KW - Breast Neoplasms -- therapy KW - Drug Resistance, Neoplasm KW - Topoisomerase Inhibitors -- pharmacology KW - MAP Kinase Kinase Kinases -- metabolism KW - MAP Kinase Kinase Kinases -- antagonists & inhibitors KW - Colonic Neoplasms -- therapy KW - Colonic Neoplasms -- drug therapy KW - Neoplasm Proteins -- genetics KW - Colonic Neoplasms -- metabolism KW - RNA Interference KW - Neoplasm Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/916852880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+cancer+drug+targets&rft.atitle=RNAi+screening+identifies+TAK1+as+a+potential+target+for+the+enhanced+efficacy+of+topoisomerase+inhibitors.&rft.au=Martin%2C+S+E%3BWu%2C+Z-H%3BGehlhaus%2C+K%3BJones%2C+T+L%3BZhang%2C+Y-W%3BGuha%2C+R%3BMiyamoto%2C+S%3BPommier%2C+Y%3BCaplen%2C+N+J&rft.aulast=Martin&rft.aufirst=S&rft.date=2011-10-01&rft.volume=11&rft.issue=8&rft.spage=976&rft.isbn=&rft.btitle=&rft.title=Current+cancer+drug+targets&rft.issn=1873-5576&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-09 N1 - Date created - 2012-01-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cancer Ther. 2006 Dec;5(12):2970-6 [17172402] Curr Med Chem. 2006;13(29):3483-92 [17168718] Nature. 2007 Apr 12;446(7137):815-9 [17429401] Oncogene. 2007 May 14;26(22):3214-26 [17496917] Cancer Cell. 2007 Jun;11(6):498-512 [17560332] Biochim Biophys Acta. 2007 Aug;1773(8):1358-75 [17481747] Annu Rev Genomics Hum Genet. 2007;8:81-108 [17477824] Cancer Chemother Pharmacol. 2008 Jan;61(1):125-31 [17426973] Expert Opin Ther Targets. 2007 Oct;11(10):1339-53 [17907963] Cancer Cell. 2008 Feb;13(2):91-104 [18242510] Oncogene. 2008 Feb 21;27(9):1198-207 [17828308] Cancer Res. 2008 Mar 1;68(5):1462-70 [18316610] J Biomol Screen. 2008 Feb;13(2):142-8 [18216392] Biochem Pharmacol. 2008 Mar 15;75(6):1262-71 [18061144] EMBO J. 2008 May 7;27(9):1368-77 [18388863] Mol Cancer. 2008;7:66 [18694480] DNA Repair (Amst). 2008 Dec 1;7(12):2010-9 [18832051] Nat Rev Cancer. 2008 Dec;8(12):957-67 [19005492] Mol Cell Biol. 2009 Jan;29(1):68-82 [18955500] Oncogene. 2009 Jun 11;28(23):2257-65 [19421137] J Biol Chem. 2009 Jul 3;284(27):18085-95 [19416980] J Transl Med. 2009;7:43 [19519883] Mol Cell Biol. 2009 Oct;29(20):5529-39 [19687304] J Biol Chem. 2010 Mar 12;285(11):8122-9 [20061393] Int J Biochem Cell Biol. 2010 May;42(5):585-9 [20060931] Cancer Res. 2010 Jun 1;70(11):4318-26 [20460535] Gynecol Oncol. 2010 Sep;118(3):220-7 [20722101] Mol Cell. 2010 Oct 8;40(1):63-74 [20932475] Mol Cell. 2010 Oct 8;40(1):75-86 [20932476] Sci Signal. 2011;4(156):pe2 [21245467] Clin Cancer Res. 2011 May 1;17(9):2744-56 [21385921] Mol Cell Biol. 2011 Jul;31(14):2774-86 [21606198] Mol Cancer Res. 2011 Aug;9(8):1042-53 [21700681] Cancer Res. 2011 Sep 1;71(17):5806-17 [21775522] Cancer Res. 1999 Dec 1;59(23):5938-46 [10606239] J Biol Chem. 2000 Mar 31;275(13):9390-5 [10734083] J Biol Chem. 2000 Mar 31;275(13):9501-9 [10734098] Cancer Res. 2002 Mar 15;62(6):1688-95 [11912141] Nat Rev Drug Discov. 2002 Jul;1(7):493-502 [12120256] Crit Rev Oncol Hematol. 2003 Jan;45(1):91-108 [12482574] J Biol Chem. 2003 May 16;278(20):18485-90 [12624112] J Biol Chem. 2003 May 30;278(22):20303-12 [12660252] Oncogene. 2003 Oct 20;22(47):7340-58 [14576842] Cancer Res. 2004 Mar 15;64(6):2096-104 [15026349] Cancer Res. 1989 Sep 15;49(18):5077-82 [2548710] Cancer Res. 1989 Nov 15;49(22):6365-8 [2553254] Cancer Res. 1990 Sep 15;50(18):6075-86 [1975513] Int J Cancer. 1999 Jul 30;82(3):396-404 [10399957] Nat Cell Biol. 2005 Jun;7(6):591-600 [15864305] Mol Cancer Ther. 2005 Jun;4(6):885-900 [15956246] J Biol Chem. 2005 Jul 29;280(30):27728-41 [15837794] Cancer Lett. 2006 Jan 8;231(1):74-86 [16356833] Science. 2006 Feb 24;311(5764):1141-6 [16497931] Nat Rev Cancer. 2006 Oct;6(10):789-802 [16990856] FASEB J. 2006 Oct;20(12):1982-91 [17012250] Oncogene. 2006 Oct 30;25(51):6800-16 [17072329] Nat Chem Biol. 2006 Dec;2(12):689-700 [17108987] Mol Cell Biol. 2006 Dec;26(24):9377-86 [17000754] Lancet Oncol. 2007 Mar;8(3):235-44 [17329194] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - coMOTIF: a mixture framework for identifying transcription factor and a coregulator motif in ChIP-seq Data AN - 915483511; 16101704 AB - Motivation: ChIP-seq data are enriched in binding sites for the protein immunoprecipitated. Some sequences may also contain binding sites for a coregulator. Biologists are interested in knowing which coregulatory factor motifs may be present in the sequences bound by the protein ChIP'ed.Results: We present a finite mixture framework with an expectation-maximization algorithm that considers two motifs jointly and simultaneously determines which sequences contain both motifs, either one or neither of them. Tested on 10 simulated ChIP-seq datasets, our method performed better than repeated application of MEME in predicting sequences containing both motifs. When applied to a mouse liver Foxa2 ChIP-seq dataset involving ~ 12 000 400-bp sequences, coMOTIF identified co-occurrence of Foxa2 with Hnf4a, Cebpa, E-box, Ap1/Maf or Sp1 motifs in ~6-33% of these sequences. These motifs are either known as liver-specific transcription factors or have an important role in liver function. JF - Bioinformatics AU - Xu, Mengyuan AU - Weinberg, Clarice R AU - Umbach, David M AU - Li, Leping AD - Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA, Y1 - 2011/10/01/ PY - 2011 DA - 2011 Oct 01 SP - 2625 EP - 2632 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 27 IS - 19 SN - 1367-4803, 1367-4803 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Sp1 protein KW - Computer programs KW - software KW - Data processing KW - Transcription factors KW - Hepatocyte nuclear factor 4 KW - Activator protein 1 KW - Liver KW - Algorithms KW - Bioinformatics KW - Internet KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/915483511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=coMOTIF%3A+a+mixture+framework+for+identifying+transcription+factor+and+a+coregulator+motif+in+ChIP-seq+Data&rft.au=Xu%2C+Mengyuan%3BWeinberg%2C+Clarice+R%3BUmbach%2C+David+M%3BLi%2C+Leping&rft.aulast=Xu&rft.aufirst=Mengyuan&rft.date=2011-10-01&rft.volume=27&rft.issue=19&rft.spage=2625&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtr397 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Computer programs; Sp1 protein; software; Data processing; Transcription factors; Activator protein 1; Hepatocyte nuclear factor 4; Algorithms; Liver; Bioinformatics; Internet DO - http://dx.doi.org/10.1093/bioinformatics/btr397 ER - TY - JOUR T1 - Care Management in Japanese Acute Psychiatric Units: A National Study AN - 914790850; 201200810 AB - Objectives: Japan has the largest number of psychiatric beds per capita in the world. Both reducing the number of beds and preventing long-term hospitalization of individuals with mental illness is essential. This study surveys Japanese acute psychiatric units to investigate the process by which care management is provided. Care management is important to prevent those with a higher need for care from becoming long-term inpatients. Methods: All of the psychiatric emergency units (PEUs) and acute psychiatric treatment units (PAUs) in Japan (N = 234) were surveyed. Chief nurses of each unit completed items from a questionnaire that assessed basic characteristics of the unit and the implementation of each element of care management (i.e., triage, assessment, care conferences, and care plan development). Additionally, the association between care management and the clinical outcomes of the unit is examined. Results: The length of stay is 52.0 days for PEUs and 65.2 days for PAUs, and more than 25 percent of patients transferred to another unit or hospital, instead of being discharged PEUs report slightly higher rates of offering each element of care management compared to PAUs. However, the overall rates are still inadequate, especially for the initial triage/screening and care plan development. The frequency of care conferences varies widely across units. While nurses and psychiatric social workers tend to participate fully, patient families and community service providers are not always included in case conferences. Care plans are developed in 58 percent of units. Only 20 percent of units had some kind of care management tool. Units implementing care management have more patients discharged to the community and have a trend for shorter lengths of stay, which suggests that care management is related to better clinical outcomes. Conclusion: The overall rates of care management in acute psychiatric units in Japan are inadequate. Dissemination of care management is, therefore, needed. Adapted from the source document. JF - International Journal of Mental Health AU - Setoya, Yutaro AU - Sato, Sayaka AU - Satake, Naoko AU - Ito, Junichiro AD - National Institute of Mental Health, National Center of Neurology and Psychiatry, Japan Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 41 EP - 54 PB - M.E. Sharpe, Armonk NY VL - 40 IS - 3 SN - 0020-7411, 0020-7411 KW - Care management KW - Discharged KW - Length of stay KW - Psychiatric units KW - Japan KW - Care plans KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/914790850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Mental+Health&rft.atitle=Care+Management+in+Japanese+Acute+Psychiatric+Units%3A+A+National+Study&rft.au=Setoya%2C+Yutaro%3BSato%2C+Sayaka%3BSatake%2C+Naoko%3BIto%2C+Junichiro&rft.aulast=Setoya&rft.aufirst=Yutaro&rft.date=2011-10-01&rft.volume=40&rft.issue=3&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Mental+Health&rft.issn=00207411&rft_id=info:doi/10.2753%2FIMH0020-7411400303 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-01-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Care management; Japan; Psychiatric units; Care plans; Length of stay; Discharged DO - http://dx.doi.org/10.2753/IMH0020-7411400303 ER - TY - JOUR T1 - Challenges and Solutions for Latin American-Trained International Medical Graduates in Psychiatry Residency AN - 914790614; 201200361 AB - Objective: Latin American-trained international medical graduates (IMGs) in psychiatry residency face multiple challenges that go beyond their medical training. These challenges call for innovative problem-solving. Although the professional development of IMGs has been discussed in the professional literature, little is written about their experiences. In this report, a group of IMGs reflect on their experiences and describe how they solved challenges. Method: Using cogenerative ethnography, four IMGs trained in Colombia, the Dominican Republic, and Mexico provided insights on their challenges and solutions while adapting to psychiatric residency training. Individual interviews, focused discussion, and written reports were analyzed using data reduction, data display, and conclusion-drawing techniques. Results: We illustrate the challenges of IMG training in psychiatry using their reflections and stories. We categorize these challenges into three domains: immigration and acculturation, social adjustment, and medical training. Quotes were selected to illustrate IMGs' challenges and coping strategies. Conclusion: Some of the combined cultural, social, and academic challenges of Latin American-trained IMGs in psychiatry residency are described. Recognizing and planning for the personal challenges of IMGs in psychiatry can enhance the transition into psychiatric training. Ultimately, improvements in IMG training converts into improved healthcare for all patients. Adapted from the source document. JF - International Journal of Mental Health AU - Hausmann-Stabile, Carolina AU - Zayas, Luis H AU - Hauser, David AU - Carvajal, Carlos AU - Mejia, Carlina AU - Nieves, Delia AD - National Institute of Mental Health predoctoral fellow at Washington University in St. Louis Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 29 EP - 40 PB - M.E. Sharpe, Armonk NY VL - 40 IS - 3 SN - 0020-7411, 0020-7411 KW - Coping strategies KW - Professional development KW - Foreign doctors KW - Mexico KW - Medical education KW - Psychiatry KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/914790614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Mental+Health&rft.atitle=Challenges+and+Solutions+for+Latin+American-Trained+International+Medical+Graduates+in+Psychiatry+Residency&rft.au=Hausmann-Stabile%2C+Carolina%3BZayas%2C+Luis+H%3BHauser%2C+David%3BCarvajal%2C+Carlos%3BMejia%2C+Carlina%3BNieves%2C+Delia&rft.aulast=Hausmann-Stabile&rft.aufirst=Carolina&rft.date=2011-10-01&rft.volume=40&rft.issue=3&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Mental+Health&rft.issn=00207411&rft_id=info:doi/10.2753%2FIMH0020-7411400302 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-01-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Psychiatry; Medical education; Foreign doctors; Mexico; Professional development; Coping strategies DO - http://dx.doi.org/10.2753/IMH0020-7411400302 ER - TY - JOUR T1 - Optimization of coronary whole-heart MRA free-breathing technique at 3 Tesla AN - 907177065; 15721079 AB - Four different techniques for 3-T whole-heart coronary magnetic resonance angiography (MRA) using free-breathing three-dimensional segmented parallel imaging and adiabatic T2-preparation were assessed. Coronary MRA at 3 T is improved by shortening the acquisition window more than employing the highest spatial resolution. Double-oblique whole-heart acquisitions result in better overall image quality and allow for better delineation of the left anterior descending coronary artery. It is possible to attain shorter acquisition windows and a smaller voxel size at 3 T than previously reported at 1.5 T. JF - Magnetic Resonance Imaging AU - Gharib, Ahmed M AU - Abd-Elmoniem, Khaled Z AU - Herzka, Daniel A AU - Ho, Vincent B AU - Locklin, Julie AU - Tzatha, Efstathia AU - Stuber, Matthias AU - Pettigrew, Roderic I Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1125 EP - 1130 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 29 IS - 8 SN - 0730-725X, 0730-725X KW - Biotechnology and Bioengineering Abstracts KW - Adiabatic KW - Angiography KW - Magnetic resonance imaging KW - N.M.R. KW - coronary artery KW - spatial discrimination KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907177065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=Optimization+of+coronary+whole-heart+MRA+free-breathing+technique+at+3+Tesla&rft.au=Gharib%2C+Ahmed+M%3BAbd-Elmoniem%2C+Khaled+Z%3BHerzka%2C+Daniel+A%3BHo%2C+Vincent+B%3BLocklin%2C+Julie%3BTzatha%2C+Efstathia%3BStuber%2C+Matthias%3BPettigrew%2C+Roderic+I&rft.aulast=Gharib&rft.aufirst=Ahmed&rft.date=2011-10-01&rft.volume=29&rft.issue=8&rft.spage=1125&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2011.07.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-12-03 N1 - SubjectsTermNotLitGenreText - Angiography; Adiabatic; Magnetic resonance imaging; spatial discrimination; N.M.R.; coronary artery DO - http://dx.doi.org/10.1016/j.mri.2011.07.008 ER - TY - JOUR T1 - Imaging tumor endothelial marker 8 using an super(18)F-labeled peptide AN - 907174034; 15690241 AB - Purpose: Tumor endothelial marker 8 (TEM8) has been reported to be upregulated in both tumor cells and tumor-associated endothelial cells in several cancer types. TEM8 antagonists and TEM8-targeted delivery of toxins have been developed as effective cancer therapeutics. The ability to image TEM8 expression would be of use in evaluating TEM8-targeted cancer therapy. Methods: A 13-meric peptide, KYNDRLPLYISNP (QQM), identified from the small loop in domain IV of protective antigen of anthrax toxin was evaluated for TEM8 binding and labeled with super(18)F for small-animal PET imaging in both UM-SCC1 head-and-neck cancer and MDA-MB-435 melanoma models. Results: A modified ELISA showed that QQM peptide bound specifically to the extracellular vWA domain of TEM8 with an IC sub(50) value of 304 nM. Coupling 4-nitrophenyl 2- super(18)F-fluoropropionate with QQM gave almost quantitative yield and a high specific activity (79.2+/-7.4 TBq/mmol, n=5) of super(18)F-FP-QQM at the end of synthesis. super(18)F-FP-QQM showed predominantly renal clearance and had significantly higher accumulation in TEM8 high-expressing UM-SCC1 tumors (2.96+/-0.84 %ID/g at 1 h after injection) than TEM8 low-expressing MDA-MB-435 tumors (1.38+/-0.56 %ID/g at 1 h after injection). Conclusion: QQM peptide bound specifically to the extracellular domain of TEM8. super(18)F-FP-QQM peptide tracer would be a promising lead compound for measuring TEM8 expression. Further efforts to improve the affinity and specificity of the tracer and to increase its metabolic stability are warranted. JF - European Journal of Nuclear Medicine and Molecular Imaging AU - Quan, Qimeng AU - Yang, Min AU - Gao, Haokao AU - Zhu, Lei AU - Lin, Xin AU - Guo, Ning AU - Zhang, Guixiang AU - Eden, Henry S AU - Niu, Gang AU - Chen, Xiaoyuan AD - Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 9 Memorial Drive, 9/1 W111, Bethesda, MD, 20892, USA Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1806 EP - 1815 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 38 IS - 10 SN - 1619-7070, 1619-7070 KW - Biotechnology and Bioengineering Abstracts KW - Enzyme-linked immunosorbent assay KW - protective antigen KW - Tumors KW - Tumor cells KW - Antagonists KW - Toxins KW - Cancer KW - Melanoma KW - Endothelial cells KW - Tracers KW - Kidney KW - Anthrax KW - Nuclear medicine KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907174034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.atitle=Imaging+tumor+endothelial+marker+8+using+an+super%2818%29F-labeled+peptide&rft.au=Quan%2C+Qimeng%3BYang%2C+Min%3BGao%2C+Haokao%3BZhu%2C+Lei%3BLin%2C+Xin%3BGuo%2C+Ning%3BZhang%2C+Guixiang%3BEden%2C+Henry+S%3BNiu%2C+Gang%3BChen%2C+Xiaoyuan&rft.aulast=Quan&rft.aufirst=Qimeng&rft.date=2011-10-01&rft.volume=38&rft.issue=10&rft.spage=1806&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.issn=16197070&rft_id=info:doi/10.1007%2Fs00259-011-1871-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; protective antigen; Tumors; Tumor cells; Cancer; Toxins; Antagonists; Melanoma; Endothelial cells; Tracers; Kidney; Nuclear medicine; Anthrax DO - http://dx.doi.org/10.1007/s00259-011-1871-4 ER - TY - JOUR T1 - The novel delta opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions AN - 904486906; 15165844 AB - We previously reported that the delta opioid receptor (DOP) agonists SNC80 and TAN-67 produce potent antidepressant-like and antinociceptive effects in rodents. However, SNC80 produced convulsive effects. Recently, we succeeded in synthesizing a novel DOP agonist called KNT-127. The present study examined the convulsive, antidepressant-like, and antinociceptive effects of KNT-127 in mice. In contrast to SNC80, KNT-127 produced no convulsions at doses of up to 100mg/kg. In mice subjected to the forced swim test, a screening model for antidepressants, KNT-127 (1mg/kg, s.c.) significantly decreased the duration of immobility and increased the duration of swimming without influencing spontaneous locomotor activity. These behavioral changes were similar to that observed for the tricyclic antidepressant imipramine (6mg/kg). The antidepressant-like effect of KNT-127 in mice was antagonized by pretreatment with naltrindole (NTI), a selective DOP antagonist, or naltriben, a putative DOP2 subtype antagonist. In addition, KNT-127 (3mg/kg, s.c.) significantly reduced the number of acetic acid-induced abdominal constrictions and the duration of licking time, respectively, in mice subjected to a writhing test and a formalin test. These antinociceptive effects were antagonized by pretreatment with either NTI or 7-benzylidenenaltrexone, a putative DOP1 subtype antagonist. We propose that KNT-127 should be considered as a candidate compound for the development of DOP-based antidepressants and/or analgesics that lack convulsive effects. JF - Behavioural Brain Research AU - Saitoh, Akiyoshi AU - Sugiyama, Azusa AU - Nemoto, Toru AU - Fujii, Hideaki AU - Wada, Keiji AU - Oka, Jun-Ichiro AU - Nagase, Hiroshi AU - Yamada, Mitsuhiko AD - Department of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo 187-8553, Japan, asaitoh@ncnp.go.jp Y1 - 2011/10/01/ PY - 2011 DA - 2011 Oct 01 SP - 271 EP - 279 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 223 IS - 2 SN - 0166-4328, 0166-4328 KW - Biotechnology and Bioengineering Abstracts; Animal Behavior Abstracts; CSA Neurosciences Abstracts KW - Antidepressants KW - Swimming KW - Naltrindole KW - Opioid receptors (type delta) KW - imipramine KW - Convulsions KW - Locomotor activity KW - Pain perception KW - Tricyclic antidepressants KW - Analgesics KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25080:Orientation, Migration and Locomotion KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904486906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+Brain+Research&rft.atitle=The+novel+delta+opioid+receptor+agonist+KNT-127+produces+antidepressant-like+and+antinociceptive+effects+in+mice+without+producing+convulsions&rft.au=Saitoh%2C+Akiyoshi%3BSugiyama%2C+Azusa%3BNemoto%2C+Toru%3BFujii%2C+Hideaki%3BWada%2C+Keiji%3BOka%2C+Jun-Ichiro%3BNagase%2C+Hiroshi%3BYamada%2C+Mitsuhiko&rft.aulast=Saitoh&rft.aufirst=Akiyoshi&rft.date=2011-10-01&rft.volume=223&rft.issue=2&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Behavioural+Brain+Research&rft.issn=01664328&rft_id=info:doi/10.1016%2Fj.bbr.2011.04.041 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Antidepressants; Swimming; Naltrindole; imipramine; Opioid receptors (type delta); Locomotor activity; Convulsions; Tricyclic antidepressants; Pain perception; Analgesics DO - http://dx.doi.org/10.1016/j.bbr.2011.04.041 ER - TY - JOUR T1 - Multisite Carcinogenicity and Respiratory Toxicity of Inhaled 1-Bromopropane in Rats and Mice AN - 902362536; 15807372 AB - Two-year 1-bromopropane (1-BP) inhalation studies were conducted because of the potential for widespread exposure, the lack of chronic toxicity and carcinogenicity data, and the known carcinogenicity of structurally related compounds. Male and female F344/N rats and B6C3F1/N mice were exposed by inhalation to 0, 62.5 (mice only), 125, 250, or 500 (rats only) ppm 1-BP for 6 hr/day, 5 days/week for 105 weeks. Exposure of male and female rats to 1-BP resulted in significantly increased incidences of adenomas of the large intestine and skin neoplasms. In male rats, the incidence of malignant mesothelioma of the epididymis was statistically significantly increased at 500 ppm, but the biological significance of this common lesion is unclear. Incidences of pancreatic islet adenoma in male rats were significantly increased at all concentrations relative to concurrent controls but were within the historical control range for inhalation studies. There was no evidence of carcinogenic activity of 1-BP in male B6C3F1 mice; however, significantly increased incidences of alveolar/bronchiolar neoplasms of the lung were present in female mice. Exposure to 1-BP also resulted in increased incidences of nonneoplastic lesions in the nose of rats and mice, the larynx of rats and male mice, the trachea of female rats and male and female mice, and the lungs of mice. Inflammatory lesions with Splendore Hoeppli (S-H) material were present primarily in the nose and skin of exposed male and female rats, indicating that 1-BP caused immunosuppression. JF - Toxicologic Pathology AU - Morgan, Daniel L AU - Nyska, Abraham AU - Harbo, Sam Jens AU - Grumbein, Sondra L AU - Dill, Jeffrey A AU - Roycroft, Joseph H AU - Kissling, Grace E AU - Cesta, Mark F AD - National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina, USA  , morgan3@niehs.nih.gov morgan3@niehs.nih.gov morgan3@niehs.nih.gov morgan3@niehs.nih.gov morgan3@niehs.nih.gov morgan3@niehs.nih.gov morgan3@niehs.nih.gov Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 938 EP - 948 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 39 IS - 6 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Inhalation KW - Skin KW - Data processing KW - Epididymis KW - Pancreas KW - Large intestine KW - Islets of Langerhans KW - Toxicity KW - Alveoli KW - Inflammation KW - Lung KW - Carcinogenicity KW - Chronic toxicity KW - Larynx KW - mesothelioma KW - Nose KW - Trachea KW - Adenoma KW - Immunosuppression KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902362536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Multisite+Carcinogenicity+and+Respiratory+Toxicity+of+Inhaled+1-Bromopropane+in+Rats+and+Mice&rft.au=Morgan%2C+Daniel+L%3BNyska%2C+Abraham%3BHarbo%2C+Sam+Jens%3BGrumbein%2C+Sondra+L%3BDill%2C+Jeffrey+A%3BRoycroft%2C+Joseph+H%3BKissling%2C+Grace+E%3BCesta%2C+Mark+F&rft.aulast=Morgan&rft.aufirst=Daniel&rft.date=2011-10-01&rft.volume=39&rft.issue=6&rft.spage=938&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623311416374 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Inhalation; Data processing; Skin; Epididymis; Pancreas; Islets of Langerhans; Large intestine; Toxicity; Alveoli; Inflammation; Carcinogenicity; Lung; Chronic toxicity; Larynx; mesothelioma; Nose; Adenoma; Trachea; Immunosuppression DO - http://dx.doi.org/10.1177/0192623311416374 ER - TY - JOUR T1 - ERD-Based Online Brain-Machine Interfaces (BMI) in the Context of Neurorehabilitation: Optimizing BMI Learning and Performance AN - 902350666; 15840810 AB - Event-related desynchronization (ERD) of sensori-motor rhythms (SMR) can be used for online brain-machine interface (BMI) control, but yields challenges related to the stability of ERD and feedback strategy to optimize BMI learning. Here, we compared two approaches to this challenge in 20 right-handed healthy subjects (HS, five sessions each, S1-S5) and four stroke patients (SP, 15 sessions each, S1-S15). ERD was recorded from a 275-sensor MEG system. During daily training, motor imagery-induced ERD led to visual and proprioceptive feedback delivered through an orthotic device attached to the subjects' hand and fingers. Group A trained with a heterogeneous reference value (RV) for ERD detection with binary feedback and Group B with a homogenous RV and graded feedback (10 HS and 2 SP in each group). HS in Group B showed better BMI performance than Group A ( p < 0.001 ) and improved BMI control from S1 to S5 ( p = 0.012 ) while Group A did not. In spite of the small n, SP in Group B showed a trend for a higher BMI performance ( p = 0.06 ) and learning was significantly better ( p < 0.05 ) . Using a homogeneous RV and graded feedback led to improved modulation of ipsilesional activity resulting in superior BMI learning relative to use of a heterogeneous RV and binary feedback. JF - IEEE Transactions on Neural Systems and Rehabilitation Engineering AU - Soekadar, Surjo R AU - Witkowski, Matthias AU - Mellinger, Juergen AU - Ramos, Ander AU - Birbaumer, Niels AU - Cohen, Leonardo G AD - Human Cortical Physiology and Stroke Neurorehabilitation Section, HCPS, NINDS, NIH, Bethesda, MD, USA Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 542 EP - 549 PB - Institute of Electrical and Electronics Engineers, Inc., 3 Park Avenue, 17th Fl New York NY 10016-5997 United States VL - 19 IS - 5 SN - 1534-4320, 1534-4320 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Magnetoencephalography KW - Handedness KW - Learning KW - Rehabilitation KW - Synchronization KW - Stroke KW - Hand KW - Sensorimotor integration KW - Substance P KW - Finger KW - Proprioception KW - Rhythms KW - Feedback KW - Internet KW - Neurology KW - N3 11002:Computational & theoretical neuroscience KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902350666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Neural+Systems+and+Rehabilitation+Engineering&rft.atitle=ERD-Based+Online+Brain-Machine+Interfaces+%28BMI%29+in+the+Context+of+Neurorehabilitation%3A+Optimizing+BMI+Learning+and+Performance&rft.au=Soekadar%2C+Surjo+R%3BWitkowski%2C+Matthias%3BMellinger%2C+Juergen%3BRamos%2C+Ander%3BBirbaumer%2C+Niels%3BCohen%2C+Leonardo+G&rft.aulast=Soekadar&rft.aufirst=Surjo&rft.date=2011-10-01&rft.volume=19&rft.issue=5&rft.spage=542&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Neural+Systems+and+Rehabilitation+Engineering&rft.issn=15344320&rft_id=info:doi/10.1109%2FTNSRE.2011.2166809 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Handedness; Magnetoencephalography; Learning; Rehabilitation; Stroke; Synchronization; Hand; Substance P; Sensorimotor integration; Finger; Proprioception; Feedback; Rhythms; Internet; Neurology DO - http://dx.doi.org/10.1109/TNSRE.2011.2166809 ER - TY - JOUR T1 - Detection of Small Bowel Polyps and Ulcers in Wireless Capsule Endoscopy Videos AN - 899162911; 15752823 AB - Over the last decade, wireless capsule endoscopy (WCE) technology has become a very useful tool for diagnosing diseases within the human digestive tract. Physicians using WCE can examine the digestive tract in a minimally invasive way searching for pathological abnormalities such as bleeding, polyps, ulcers, and Crohn's disease. To improve effectiveness of WCE, researchers have developed software methods to automatically detect these diseases at a high rate of success. This paper proposes a novel synergistic methodology for automatically discovering polyps (protrusions) and perforated ulcers in WCE video frames. Finally, results of the methodology are given and statistical comparisons are also presented relevant to other works. JF - IEEE Transactions on Biomedical Engineering AU - Karargyris, Alexandros AU - Bourbakis, Nikolaos AD - National Library of Medicine (NLM) of National Institutes of Health (NIH), Bethesda, USA Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 2777 EP - 2786 PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 United States VL - 58 IS - 10 SN - 0018-9294, 0018-9294 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Crohn's disease KW - software KW - Digestive tract KW - Statistics KW - Ulcers KW - Energy KW - Intestine KW - Bleeding KW - Polyps KW - Endoscopy KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899162911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=IEEE+Transactions+on+Biomedical+Engineering&rft.atitle=Detection+of+Small+Bowel+Polyps+and+Ulcers+in+Wireless+Capsule+Endoscopy+Videos&rft.au=Karargyris%2C+Alexandros%3BBourbakis%2C+Nikolaos&rft.aulast=Karargyris&rft.aufirst=Alexandros&rft.date=2011-10-01&rft.volume=58&rft.issue=10&rft.spage=2777&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Biomedical+Engineering&rft.issn=00189294&rft_id=info:doi/10.1109%2FTBME.2011.2155064 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Crohn's disease; Computer programs; software; Statistics; Digestive tract; Ulcers; Energy; Bleeding; Intestine; Polyps; Endoscopy DO - http://dx.doi.org/10.1109/TBME.2011.2155064 ER - TY - JOUR T1 - A Prospective Analysis of Prolonged Sitting Time and Risk of Renal Cell Carcinoma Among 300,000 Older Adults AN - 899141339; 15796521 AB - Purpose: Accumulating evidence suggests an etiologic role in renal cell carcinoma (RCC) for physical activity. However, it is unknown if prolonged sitting, which is thought to be distinct from too little moderate-vigorous physical activity, is an independent risk factor for RCC. The authors prospectively examined the relationship of prolonged sitting and risk of RCC among 289,512 women and men in the National Institutes of Health-AARP Diet and Health Study. Methods: From 1996 through 2006, 1206 invasive RCC cancer cases were identified. Cox proportional hazards regression was used to estimate multivariate hazard ratios (HR) and 95% confidence intervals. Results: After controlling for known risk factors for RCC, we did not find evidence of associations between RCC risk and time spent per day sitting while watching television or videos (HR sub(7+hrs:1 hr = 0.96 (0.66, 1.38); p trend = 0.707) or total sitting time (HR) sub(9)+hrs: 3hrs = 1.11 (0.87, 1.41); p trend = 0.765). Conclusions: Prolonged sitting time was not associated with RCC risk among men and women in this large cohort. JF - Annals of Epidemiology AU - George, Stephanie M AU - Moore, Steven C AU - Chow, Wong-Ho AU - Schatzkin, Arthur AU - Hollenbeck, Albert R AU - Matthews, Charles E AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, materess@mail.nih.gov Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 787 EP - 790 PB - Elsevier B.V., Box 882 New York NY 10159 United States VL - 21 IS - 10 SN - 1047-2797, 1047-2797 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Diets KW - Risk factors KW - Television KW - physical activity KW - Cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899141339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=A+Prospective+Analysis+of+Prolonged+Sitting+Time+and+Risk+of+Renal+Cell+Carcinoma+Among+300%2C000+Older+Adults&rft.au=George%2C+Stephanie+M%3BMoore%2C+Steven+C%3BChow%2C+Wong-Ho%3BSchatzkin%2C+Arthur%3BHollenbeck%2C+Albert+R%3BMatthews%2C+Charles+E&rft.aulast=George&rft.aufirst=Stephanie&rft.date=2011-10-01&rft.volume=21&rft.issue=10&rft.spage=787&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2011.04.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diets; Risk factors; Television; physical activity; Cancer DO - http://dx.doi.org/10.1016/j.annepidem.2011.04.012 ER - TY - JOUR T1 - Dietary fiber and grain consumption in relation to head and neck cancer in the NIH-AARP Diet and Health Study AN - 899140544; 15759587 AB - Background: Dietary fiber and grain consumption may reduce the risk of head and neck cancer; however, the epidemiological evidence is limited. We investigated this relationship in the National Institutes of Health (NIH)-AARP Diet and Health Study. Methods: Cox proportional hazards models were used to calculate multivariable hazard ratios (HR) and 95% confidence intervals (CI) to investigate dietary fiber and grain intake in relation to head and neck cancer. Results: During approximately 11 years of follow-up, 1,867 (401 women/1,466 men) cases of head and neck cancer were diagnosed. Our data indicated that the relationship between fiber and grain intake and head and neck cancer is modified by sex (p-interactions < 0.001 and 0.001, respectively). Women with higher intake of total fiber and total grains had a lower risk of head and neck cancer (HR sub(10g/day) = 0.77, 95% CI = 0.64-0.93; HR sub(serving/1,000kcal) = 0.89, 95% CI = 0.80-0.99, respectively); this inverse relation was consistent across subtypes of fiber and grains. Conversely in men, the inverse associations were weaker and nonsignificant. Conclusions: In the largest prospective cohort study to investigate this relation to date, intake of total fiber and grain foods was inversely associated with head and neck cancer incidence among women, but not among men. JF - Cancer Causes & Control AU - Lam, Tram Kim AU - Cross, Amanda J AU - Freedman, Neal AU - Park, Yikyung AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Abnet, Christian AD - Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH), Rockville, MD, 20852, USA, lamt@mail.nih.gov lamt@mail.nih.gov lamt@mail.nih.gov lamt@mail.nih.gov lamt@mail.nih.gov lamt@mail.nih.gov Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1405 EP - 1414 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 22 IS - 10 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Diets KW - Fibers KW - risk reduction KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899140544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Dietary+fiber+and+grain+consumption+in+relation+to+head+and+neck+cancer+in+the+NIH-AARP+Diet+and+Health+Study&rft.au=Lam%2C+Tram+Kim%3BCross%2C+Amanda+J%3BFreedman%2C+Neal%3BPark%2C+Yikyung%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur%3BAbnet%2C+Christian&rft.aulast=Lam&rft.aufirst=Tram&rft.date=2011-10-01&rft.volume=22&rft.issue=10&rft.spage=1405&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9813-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diets; risk reduction; Fibers; Cancer DO - http://dx.doi.org/10.1007/s10552-011-9813-9 ER - TY - JOUR T1 - Attitudinal, Behavioral, and Biological Outcomes of a Community Popular Opinion Leader Intervention in China AN - 898919896; 22010808 AB - The effects of a community popular opinion leader (CPOL) intervention were examined among market vendors in a city on the eastern coast of China. Employees of 40 food markets were enrolled in a study that provided HIV-related education and tests, and treatment for sexually transmitted diseases (STDs). Twenty markets were randomly assigned to a CPOL intervention (N == 1,695) and 20 markets to a control condition (N == 1,616). Market employees in the intervention condition reported positive attitudes regarding STD/HIV prevention and more frequent discussions about safe sex than those in the control condition. Compared with baseline, the prevalence of unprotected sexual acts and new STDs were significantly lower within each study condition 24 months later. Although the CPOL intervention achieved its goal of shifting attitudes within food markets, the gains did not lead to the expected behavioral and biological outcomes. [PUBLICATION ABSTRACT] JF - AIDS Education and Prevention AU - Rotheram-Borus, Mary Jane AU - Li, Li AU - Liang, Li-Jung AU - Wen, Yi AU - Wu, Zunyou Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 448 EP - 56 CY - New York PB - Guilford Publications, Inc. VL - 23 IS - 5 SN - 08999546 KW - Medical Sciences--Communicable Diseases KW - Human immunodeficiency virus--HIV KW - Health education KW - Diagnostic tests KW - Sexually transmitted diseases--STD KW - Grocery stores KW - Employees KW - China KW - Young Adult KW - Humans KW - Safe Sex -- statistics & numerical data KW - Interpersonal Relations KW - Peer Group KW - Sexually Transmitted Diseases -- epidemiology KW - Unsafe Sex -- prevention & control KW - China -- epidemiology KW - Adult KW - Commerce KW - Follow-Up Studies KW - Middle Aged KW - Adolescent KW - HIV Infections -- epidemiology KW - Female KW - Male KW - Prevalence KW - Health Promotion -- methods KW - HIV Infections -- prevention & control KW - Health Knowledge, Attitudes, Practice KW - Health Education -- methods KW - Sexually Transmitted Diseases -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/898919896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acriminaljusticeperiodicals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Education+and+Prevention&rft.atitle=Attitudinal%2C+Behavioral%2C+and+Biological+Outcomes+of+a+Community+Popular+Opinion+Leader+Intervention+in+China&rft.au=Rotheram-Borus%2C+Mary+Jane%3BLi%2C+Li%3BLiang%2C+Li-Jung%3BWen%2C+Yi%3BWu%2C+Zunyou&rft.aulast=Rotheram-Borus&rft.aufirst=Mary&rft.date=2011-10-01&rft.volume=23&rft.issue=5&rft.spage=448&rft.isbn=&rft.btitle=&rft.title=AIDS+Education+and+Prevention&rft.issn=08999546&rft_id=info:doi/101521aeap2011235448 LA - English DB - ProQuest Central N1 - Copyright - © 2011 The Guilford Press N1 - Last updated - 2014-04-04 N1 - CODEN - AEPREO N1 - SubjectsTermNotLitGenreText - China DO - http://dx.doi.org/101521aeap2011235448 ER - TY - JOUR T1 - Outcome of advanced NSCLC patients harboring sensitizing EGFR mutations randomized to EGFR tyrosine kinase inhibitors or chemotherapy as first-line treatment: a meta-analysis. AN - 894820576; 21325444 AB - Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) are effective as first-line treatment of advanced non-small-cell lung cancer patients with EGFR mutations (EGFR-M+). We conducted a literature-based meta-analysis to quantify the magnitude of benefit with upfront EGFR TKI in EGFR-M+ patients. Meta-regression and sensitivity analyses were also carried out to identify additional predictors of outcome and to assess the influence of trial design. Five trials (805 patients) were identified (three trials prospectively enrolling EGFR-M+ patients and two retrospective analyses of EGFR-M+ patients). TKI significantly increased progression-free survival (PFS) [hazard ratio (HR) 0.45, 95% confidence interval (CI) 0.36-0.58, P < 0.0001] and overall response rate (ORR) (HR 2.08, 95% CI 1.75-2.46, P < 0.0001)] over chemotherapy, while significantly decreasing neutropenia. No significant difference was observed in overall survival. The rate of exon-19 mutations, female gender, and nonsmoking status were identified as additional predictors of outcome at meta-regression analysis. A significant interaction with trial design was found for both PFS (P = 0.028) and ORR (P = 0.008), suggesting a larger advantage for patients treated within prospective trials. In EGFR-M+ patients, first-line TKI increase both PFS and ORR by ~25%, while significantly decreasing toxicity. The role of additional predictive factors and the influence of trial design on the magnitude of the observed benefit warrant further investigation. JF - Annals of oncology : official journal of the European Society for Medical Oncology AU - Bria, E AU - Milella, M AU - Cuppone, F AU - Novello, S AU - Ceribelli, A AU - Vaccaro, V AU - Sperduti, I AU - Gelibter, A AU - Scagliotti, G V AU - Cognetti, F AU - Giannarelli, D AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Rome, Italy. emiliobria@yahoo.it Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 2277 EP - 2285 VL - 22 IS - 10 KW - Protein Kinase Inhibitors KW - 0 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Sex Factors KW - Humans KW - Male KW - Female KW - Lung Neoplasms -- enzymology KW - Receptor, Epidermal Growth Factor -- antagonists & inhibitors KW - Receptor, Epidermal Growth Factor -- genetics KW - Protein Kinase Inhibitors -- therapeutic use KW - Protein Kinase Inhibitors -- adverse effects KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - Lung Neoplasms -- drug therapy KW - Lung Neoplasms -- genetics KW - Carcinoma, Non-Small-Cell Lung -- enzymology KW - Mutation KW - Carcinoma, Non-Small-Cell Lung -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/894820576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.atitle=Outcome+of+advanced+NSCLC+patients+harboring+sensitizing+EGFR+mutations+randomized+to+EGFR+tyrosine+kinase+inhibitors+or+chemotherapy+as+first-line+treatment%3A+a+meta-analysis.&rft.au=Bria%2C+E%3BMilella%2C+M%3BCuppone%2C+F%3BNovello%2C+S%3BCeribelli%2C+A%3BVaccaro%2C+V%3BSperduti%2C+I%3BGelibter%2C+A%3BScagliotti%2C+G+V%3BCognetti%2C+F%3BGiannarelli%2C+D&rft.aulast=Bria&rft.aufirst=E&rft.date=2011-10-01&rft.volume=22&rft.issue=10&rft.spage=2277&rft.isbn=&rft.btitle=&rft.title=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.issn=1569-8041&rft_id=info:doi/10.1093%2Fannonc%2Fmdq742 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-12 N1 - Date created - 2011-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eval Health Prof. 2002 Jun;25(2):210-24 [12026754] Lancet Oncol. 2001 Aug;2(8):475-82 [11905723] Lung Cancer. 2004 Aug;45(2):143-52 [15246184] BMJ. 1998 Nov 7;317(7168):1309-12 [9804726] Stat Med. 1998 Dec 30;17(24):2815-34 [9921604] Lung Cancer. 2006 Jan;51(1):13-9 [16313999] Anticancer Drugs. 2006 Apr;17(4):401-9 [16549997] Cancer Treat Rev. 2006 Nov;32(7):572-6 [16914268] Nat Rev Cancer. 2007 Mar;7(3):169-81 [17318210] J Clin Oncol. 2007 Aug 1;25(22):3274-80 [17664474] J Clin Oncol. 2008 Sep 10;26(26):4268-75 [18626007] J Clin Oncol. 2008 Sep 10;26(26):4244-52 [18779611] Lancet. 2008 Nov 22;372(9652):1809-18 [19027483] Lung Cancer. 2009 Jan;63(1):50-7 [18565615] Nat Rev Clin Oncol. 2009 Jun;6(6):352-66 [19483740] J Clin Oncol. 2009 Aug 20;27(24):4027-34 [19597023] N Engl J Med. 2009 Sep 3;361(10):947-57 [19692680] N Engl J Med. 2009 Sep 3;361(10):958-67 [19692684] Lung Cancer. 2009 Dec;66(3):386-92 [19304339] Int J Cancer. 2010 Feb 1;126(3):651-5 [19609951] J Clin Oncol. 2009 Dec 20;27(36):6251-66 [19917871] J Clin Oncol. 2010 Feb 10;28(5):713-5 [20038722] Lancet Oncol. 2010 Feb;11(2):121-8 [20022809] J Thorac Oncol. 2010 May;5(5):620-30 [20354456] Lancet Oncol. 2010 Jun;11(6):521-9 [20493771] N Engl J Med. 2010 Jun 24;362(25):2380-8 [20573926] J Thorac Oncol. 2010 Jul;5(7):1011-7 [20502360] J Thorac Oncol. 2010 Jul;5(7):1001-10 [20526205] J Clin Oncol. 2011 Jul 20;29(21):2866-74 [21670455] Oncologist. 2002;7(3):181-7 [12065789] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annonc/mdq742 ER - TY - JOUR T1 - Genomic modeling of tumor onset and progression in a mouse model of aggressive human liver cancer. AN - 894812815; 21771728 AB - A comprehensive understanding of molecular mechanisms driving cancer onset and progression should provide a basis for improving early diagnosis, biomarker discovery and treatment options. A key value of genetically engineered mice for modeling human cancer is the possibility to analyze the entire process of tumor development. Here, we applied functional genomics approach to study step-by-step development of hepatocellular carcinoma (HCC) in the c-Myc/Tgfα transgenic mouse model of aggressive human liver cancer. We report that coexpression of c-Myc and Tgfα induces progressive and cumulative transcriptional alterations in the course of liver oncogenesis. Functional analysis of deregulated genes at the early stage of HCC disease supports a model of active hepatocyte proliferation on the background of chronic oxidative stress generated by a general metabolic disorder. In addition, early and persistent deregulation of numerous immune-related genes suggested that disruption of immune microenvironment may contribute to oncogenic process in this model of accelerated liver carcinogenesis. In particularly, by flow cytometry analysis, we found loss of the major histocompatibility complex class I expression in dysplastic hepatocytes followed by upregulation of numerous activating ligands for natural killer (NK) cells concomitant with a drastic decrease in hepatic NK cell frequency. In conclusion, our study provides a comprehensive characterization of sequential molecular changes during a stepwise progression of preneoplastic lesions toward HCC and highlights a critical role of metabolic disorders and innate immunity at the early stages of liver cancer. JF - Carcinogenesis AU - Coulouarn, Cédric AU - Factor, Valentina M AU - Conner, Elizabeth A AU - Thorgeirsson, Snorri S AD - National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 1434 EP - 1440 VL - 32 IS - 10 KW - Biomarkers, Tumor KW - 0 KW - Proto-Oncogene Proteins c-myc KW - RNA, Messenger KW - Transforming Growth Factor alpha KW - Index Medicus KW - Animals KW - Biomarkers, Tumor -- genetics KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Disease Progression KW - Mice KW - Hepatocytes -- pathology KW - T-Lymphocytes -- pathology KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Mice, Transgenic KW - Biomarkers, Tumor -- metabolism KW - Gene Expression Profiling KW - T-Lymphocytes -- metabolism KW - Flow Cytometry KW - Killer Cells, Natural -- pathology KW - Killer Cells, Natural -- metabolism KW - T-Lymphocytes -- immunology KW - Male KW - Killer Cells, Natural -- immunology KW - Hepatocytes -- metabolism KW - Liver Neoplasms, Experimental -- pathology KW - Liver Neoplasms, Experimental -- etiology KW - Carcinoma, Hepatocellular -- etiology KW - Transforming Growth Factor alpha -- physiology KW - Proto-Oncogene Proteins c-myc -- physiology KW - Carcinoma, Hepatocellular -- pathology KW - Disease Models, Animal KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/894812815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Genomic+modeling+of+tumor+onset+and+progression+in+a+mouse+model+of+aggressive+human+liver+cancer.&rft.au=Coulouarn%2C+C%C3%A9dric%3BFactor%2C+Valentina+M%3BConner%2C+Elizabeth+A%3BThorgeirsson%2C+Snorri+S&rft.aulast=Coulouarn&rft.aufirst=C%C3%A9dric&rft.date=2011-10-01&rft.volume=32&rft.issue=10&rft.spage=1434&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgr133 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-29 N1 - Date created - 2011-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2000 Jul 6;19(29):3225-34 [10918579] J Autoimmun. 2009 Nov-Dec;33(3-4):275-81 [19682859] Cell. 2001 May 18;105(4):445-57 [11371342] Genes Dev. 2001 Jul 15;15(14):1765-70 [11459826] Nature. 2001 Sep 13;413(6852):165-71 [11557981] Nat Genet. 2002 Aug;31(4):339-46 [12149612] Biochem Biophys Res Commun. 2002 Sep 13;297(1):59-64 [12220508] Science. 2002 Oct 11;298(5592):422-4 [12376703] J Clin Invest. 2002 Nov;110(10):1503-13 [12438448] Hepatology. 2004 Sep;40(3):667-76 [15349906] Gastroenterology. 2004 Nov;127(5 Suppl 1):S27-34 [15508094] Cell. 1990 Jun 15;61(6):1137-46 [2350785] Cancer Res. 1993 Apr 15;53(8):1719-23 [8467484] Cell. 1996 Feb 23;84(4):623-31 [8598048] Cancer Res. 1996 May 1;56(9):2137-42 [8616862] Am J Pathol. 1996 Aug;149(2):407-28 [8701981] Cancer Res. 1998 Jan 1;58(1):123-34 [9426068] J Biol Chem. 1998 Jun 19;273(25):15846-53 [9624185] Am J Pathol. 1999 Apr;154(4):1047-55 [10233843] Am J Pathol. 1999 Jun;154(6):1693-700 [10362794] Nat Genet. 2004 Dec;36(12):1306-11 [15565109] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] J Exp Med. 2005 Nov 7;202(9):1279-88 [16275765] J Immunol. 2005 Dec 15;175(12):7791-5 [16339512] Hepatology. 2006 Feb;43(2 Suppl 1):S54-62 [16447271] Nat Rev Immunol. 2006 Oct;6(10):715-27 [16977338] Hepatology. 2006 Oct;44(4):1003-11 [17006931] Cancer Res. 2006 Nov 15;66(22):11005-12 [17108139] Hepatology. 2008 Feb;47(2):729-36 [18167066] Clin Sci (Lond). 2008 Apr;114(7):457-66 [18302533] Hepatology. 2008 Jun;47(6):2059-67 [18506891] Oncogene. 2008 Oct 6;27(45):5932-43 [18836474] Oncogene. 2008 Oct 6;27(45):5944-58 [18836475] Curr Mol Med. 2009 Aug;9(6):667-72 [19689293] Nat Immunol. 2000 Dec;1(6):515-20 [11101874] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgr133 ER - TY - JOUR T1 - A phase II trial of single-agent bevacizumab in patients with recurrent anaplastic glioma. AN - 893978826; 21865400 AB - The purpose of this study was to evaluate the activity of single-agent bevacizumab in patients with recurrent anaplastic glioma and assess correlative advanced imaging parameters. Patients with recurrent anaplastic glioma were treated with bevacizumab 10 mg/kg every 2 weeks. Complete patient evaluations were repeated every 4 weeks. Correlative dynamic contrast-enhanced MR and (18)fluorodeoxyglucose PET imaging studies were obtained to evaluate physiologic changes in tumor and tumor vasculature at time points including baseline, 96 h after the first dose, and after the first 4 weeks of therapy. Median overall survival was 12 months (95% confidence interval [CI]: 6.08-22.8). Median progression-free survival was 2.93 months (95% CI: 2.01-4.93), and 6-month progression-free survival was 20.9% (95% CI: 10.3%-42.5%). Thirteen (43%) patients achieved a partial response. The most common grade ≥ 3 treatment-related toxicities were hypertension, hypophosphatemia, and thromboembolism. Single-agent bevacizumab produces significant radiographic response in patients with recurrent anaplastic glioma but did not meet the 6-month progression-free survival endpoint. Early change in enhancing tumor volume at 4 days after start of therapy was the most significant prognostic factor for overall and progression-free survival. JF - Neuro-oncology AU - Kreisl, Teri N AU - Zhang, Weiting AU - Odia, Yazmin AU - Shih, Joanna H AU - Butman, John A AU - Hammoud, Dima AU - Iwamoto, Fabio M AU - Sul, Joohee AU - Fine, Howard A AD - The Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA. kreislt@mail.nih.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 1143 EP - 1150 VL - 13 IS - 10 KW - Antibodies, Monoclonal, Humanized KW - 0 KW - Antineoplastic Agents KW - Bevacizumab KW - 2S9ZZM9Q9V KW - Index Medicus KW - Magnetic Resonance Imaging KW - Kaplan-Meier Estimate KW - Young Adult KW - Disease-Free Survival KW - Positron-Emission Tomography KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Male KW - Female KW - Brain Neoplasms -- pathology KW - Glioma -- pathology KW - Antibodies, Monoclonal, Humanized -- therapeutic use KW - Glioma -- drug therapy KW - Brain Neoplasms -- drug therapy KW - Brain Neoplasms -- mortality KW - Glioma -- mortality KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893978826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuro-oncology&rft.atitle=A+phase+II+trial+of+single-agent+bevacizumab+in+patients+with+recurrent+anaplastic+glioma.&rft.au=Kreisl%2C+Teri+N%3BZhang%2C+Weiting%3BOdia%2C+Yazmin%3BShih%2C+Joanna+H%3BButman%2C+John+A%3BHammoud%2C+Dima%3BIwamoto%2C+Fabio+M%3BSul%2C+Joohee%3BFine%2C+Howard+A&rft.aulast=Kreisl&rft.aufirst=Teri&rft.date=2011-10-01&rft.volume=13&rft.issue=10&rft.spage=1143&rft.isbn=&rft.btitle=&rft.title=Neuro-oncology&rft.issn=1523-5866&rft_id=info:doi/10.1093%2Fneuonc%2Fnor091 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-13 N1 - Date created - 2011-09-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 1999 Aug;17(8):2572-8 [10561324] Cancer Chemother Pharmacol. 2011 Sep;68(3):631-41 [21120480] J Clin Oncol. 1990 Jul;8(7):1277-80 [2358840] Comput Biomed Res. 1996 Jun;29(3):162-73 [8812068] Comput Methods Programs Biomed. 2006 Dec;84(2-3):76-85 [17050032] Neuro Oncol. 2008 Apr;10(2):162-70 [18356283] J Neurosurg. 2008 Aug;109(2):268-72 [18671639] Clin Cancer Res. 2008 Nov 1;14(21):7068-73 [18981004] Acta Oncol. 2009;48(1):52-8 [19031176] J Neurooncol. 2009 Feb;91(3):329-36 [18953493] J Clin Oncol. 2009 Feb 10;27(5):740-5 [19114704] J Neurooncol. 2009 Apr;92(2):149-55 [19043778] Cancer Res. 2009 Jul 1;69(13):5296-300 [19549889] J Clin Oncol. 2009 Oct 1;27(28):4733-40 [19720927] J Magn Reson Imaging. 2010 Feb;31(2):490-501 [20099364] J Clin Oncol. 2010 Apr 10;28(11):1963-72 [20231676] J Neurosurg. 1977 Sep;47(3):329-35 [894339] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/neuonc/nor091 ER - TY - JOUR T1 - Defective dendritic cell generation from monocytes is a potential reason for poor therapeutic efficacy of interferon α2b (IFNα2b) in cervical cancer. AN - 892950680; 21925117 AB - Despite being a pleiotropic cytokine, the therapeutic potential of interferon α2b (IFNα2b) is debatable. Thus, the need for identifying predictive marker(s) for patients who are most likely to benefit from the treatment is pivotal for avoiding the exposure of nonresponsive patients to the toxicity of the treatment. To account for the attenuated efficacy of the drug, we have verified its dendritic cell (DC) maturating ability from monocytes of cervical cancer stage IIIB (CaCx-IIIB) patients. First, we evaluated the status of monocytes from CaCx-IIIB and healthy women by conducting flow cytometric studies of various activation markers and a cytokine analysis by enzyme-linked immunosorbent assay (ELISA) and flow cytometry. Immature DCs were then generated from these monocytes and matured with low-dose IFNα2b (1500 units/mL). A functional and phenotypic comparative analysis of these matured DCs was performed by flow cytometric, proliferative, cytotoxic, and enzyme-linked immunosorbent assays. Our study shows that monocytes isolated from CaCx-IIIB are impaired, and in vitro maturation with IFNα2b did not significantly improve the functional repertoire of DCs generated from these monocytes in comparison with healthy controls. This impairment of monocytes might be a plausible reason for the attenuated efficacy of this drug alone in treating CaCx-IIIB patients, and this imbalance of immune parameters associated with the stage of malignancy might be considered an effective marker to design a proper therapeutic regimen. Copyright © 2011 Mosby, Inc. All rights reserved. JF - Translational research : the journal of laboratory and clinical medicine AU - Roy, Soumyabrata AU - Goswami, Shyamal AU - Bose, Anamika AU - Goswami, Kuntal Kanti AU - Sarkar, Koustav AU - Chakraborty, Krishnendu AU - Chakraborty, Tathagata AU - Pal, Smarajit AU - Haldar, Atanu AU - Basu, Parthasarathi AU - Biswas, Jaydip AU - Baral, Rathindranath AD - Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata 700026, India. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 200 EP - 213 VL - 158 IS - 4 KW - Cytokines KW - 0 KW - Interferon-alpha KW - Recombinant Proteins KW - Receptor, Interferon alpha-beta KW - 156986-95-7 KW - interferon alfa-2b KW - 43K1W2T1M6 KW - Abridged Index Medicus KW - Index Medicus KW - Treatment Failure KW - Antigen Presentation -- drug effects KW - Cytokines -- biosynthesis KW - Humans KW - Aged KW - Translational Medical Research KW - Cell Differentiation -- immunology KW - Lymphocyte Activation KW - CD8-Positive T-Lymphocytes -- immunology KW - Adult KW - In Vitro Techniques KW - Case-Control Studies KW - Middle Aged KW - Cell Differentiation -- drug effects KW - Receptor, Interferon alpha-beta -- metabolism KW - Female KW - Dendritic Cells -- pathology KW - Interferon-alpha -- therapeutic use KW - Interferon-alpha -- adverse effects KW - Dendritic Cells -- immunology KW - Uterine Cervical Neoplasms -- drug therapy KW - Monocytes -- immunology KW - Dendritic Cells -- drug effects KW - Monocytes -- pathology KW - Monocytes -- drug effects KW - Uterine Cervical Neoplasms -- immunology KW - Uterine Cervical Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/892950680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Translational+research+%3A+the+journal+of+laboratory+and+clinical+medicine&rft.atitle=Defective+dendritic+cell+generation+from+monocytes+is+a+potential+reason+for+poor+therapeutic+efficacy+of+interferon+%CE%B12b+%28IFN%CE%B12b%29+in+cervical+cancer.&rft.au=Roy%2C+Soumyabrata%3BGoswami%2C+Shyamal%3BBose%2C+Anamika%3BGoswami%2C+Kuntal+Kanti%3BSarkar%2C+Koustav%3BChakraborty%2C+Krishnendu%3BChakraborty%2C+Tathagata%3BPal%2C+Smarajit%3BHaldar%2C+Atanu%3BBasu%2C+Parthasarathi%3BBiswas%2C+Jaydip%3BBaral%2C+Rathindranath&rft.aulast=Roy&rft.aufirst=Soumyabrata&rft.date=2011-10-01&rft.volume=158&rft.issue=4&rft.spage=200&rft.isbn=&rft.btitle=&rft.title=Translational+research+%3A+the+journal+of+laboratory+and+clinical+medicine&rft.issn=1878-1810&rft_id=info:doi/10.1016%2Fj.trsl.2011.03.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-08 N1 - Date created - 2011-09-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Transl Res. 2011 Oct;158(4):197-9 [21925116] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.trsl.2011.03.003 ER - TY - JOUR T1 - High prevalence of human papillomavirus infection in Eastern European and West African women immigrants in South Italy. AN - 890679307; 21917007 AB - Surveillance of human papillomavirus (HPV) prevalence and genotype distribution in migrant women from middle and low-income countries to developed countries is limited. The aim of this study was to analyze the spectrum of HPV genotypes and prevalence of cervical abnormalities in women emigrated mainly from Eastern Europe and West Africa and living in Southern Italy. The study included 233 migrant and 98 Italian-born women who self-referred to two gynecological outpatient clinics in the Campania region. Cervical specimens were subjected to cytological examination and viral testing by broad spectrum PCR. The prevalence rates of HPV infection were 57.9% and 94.1% among migrant and 19.4% and 88.5% among Italian women with normal and abnormal cytology respectively. HPV infection was detected in 56.1% of Southern and Eastern European, 62.5% of Central and South American, 55.5% of West African, and 73.3% of Southern Asian women with normal cervix. Among the 140 HPV-positive migrants, a total of 28 mucosal HPV genotypes were identified of which 11 types (HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, and 58), epidemiological classified as carcinogenic to humans (group 1), accounted for 73.4% of all infections. As expected, HPV16 was the most common viral type in all groups with frequency rates ranging from 12.5% in African to 30.1% in Eastern and Southern European women. In conclusion, the estimated prevalence of HPV infection among migrant women is very high, probably reflecting either lifestyle or high incidence of HPV in their country of origin. The implementation of vaccination strategies and cervical cancer surveillance are critical for women in this risk group. © 2011 The Authors. APMIS © 2011 APMIS. JF - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica AU - Tornesello, Maria Lina AU - Cassese, Rosaria AU - De Rosa, Nicoletta AU - Buonaguro, Luigi AU - Masucci, Anna AU - Vallefuoco, Gabriele AU - Palmieri, Stefano AU - Schiavone, Vincenzo AU - Piccoli, Roberto AU - Buonaguro, Franco M AD - Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute, "Fond. Pascale", Naples, Italy. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 701 EP - 709 VL - 119 IS - 10 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Young Adult KW - Uterine Cervical Diseases -- diagnosis KW - Chi-Square Distribution KW - Humans KW - Uterine Cervical Diseases -- virology KW - Aged KW - Europe, Eastern -- ethnology KW - Polymerase Chain Reaction KW - DNA, Viral -- chemistry KW - Adult KW - Vaginal Smears KW - Cervix Uteri -- cytology KW - Cervix Uteri -- virology KW - Middle Aged KW - Italy -- epidemiology KW - Uterine Cervical Diseases -- epidemiology KW - DNA, Viral -- genetics KW - Female KW - Prevalence KW - Africa -- ethnology KW - Papillomavirus Infections -- epidemiology KW - Papillomavirus Infections -- diagnosis KW - Papillomaviridae -- isolation & purification KW - Papillomavirus Infections -- virology KW - Papillomaviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/890679307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=APMIS+%3A+acta+pathologica%2C+microbiologica%2C+et+immunologica+Scandinavica&rft.atitle=High+prevalence+of+human+papillomavirus+infection+in+Eastern+European+and+West+African+women+immigrants+in+South+Italy.&rft.au=Tornesello%2C+Maria+Lina%3BCassese%2C+Rosaria%3BDe+Rosa%2C+Nicoletta%3BBuonaguro%2C+Luigi%3BMasucci%2C+Anna%3BVallefuoco%2C+Gabriele%3BPalmieri%2C+Stefano%3BSchiavone%2C+Vincenzo%3BPiccoli%2C+Roberto%3BBuonaguro%2C+Franco+M&rft.aulast=Tornesello&rft.aufirst=Maria&rft.date=2011-10-01&rft.volume=119&rft.issue=10&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=APMIS+%3A+acta+pathologica%2C+microbiologica%2C+et+immunologica+Scandinavica&rft.issn=1600-0463&rft_id=info:doi/10.1111%2Fj.1600-0463.2011.02784.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-08 N1 - Date created - 2011-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1600-0463.2011.02784.x ER - TY - JOUR T1 - The cannabinoid receptor inverse agonist AM251 regulates the expression of the EGF receptor and its ligands via destabilization of oestrogen-related receptor α protein. AN - 888338721; 21449913 AB - AM251 is an inverse agonist of the cannabinoid 1 receptor (CB(1)R) that can exert 'off-target' effects in vitro and in CB(1)R knock-out mice. AM251 is also potent at modulating tumour cell growth, suggesting that growth factor-mediated oncogenic signalling could be regulated by AM251. Since dysregulation of the EGF receptor has been associated with carcinogenesis, we examined AM251 regulation of EGF receptor (EGFR) expression and function. The various biological functions of AM251 were measured in CB(1)R-negative human cancer cells. Pharmacological and genetic approaches were used to validate the data. The mRNA levels for EGFR and its associated ligands, including HB-EGF, were induced several fold in PANC-1 and HCT116 cells in response to AM251. This event was associated with enhanced expression of EGFR on the cell surface with concomitant increase in EGF-induced cellular responses in AM251-treated cells. Exposure to XCT790, a synthetic inverse agonist of the orphan nuclear oestrogen-related receptor α (ERRα), also induced EGFR and HB-EGF expression to the same extent as AM251, whereas pretreatment with the ERRα-selective agonist, biochanin A, blunted AM251 actions. AM251 promoted the degradation of ERRα protein without loss of the corresponding mRNA. Knock-down of ERRα by siRNA-based approach led to constitutive induction of EGFR and HB-EGF levels, and eliminated the biological responses of AM251 and XCT790. Finally, AM251 displaced diethylstilbestrol prebound to the ligand-binding domain of ERRα. AM251 up-regulates EGFR expression and signalling via a novel non-CB(1)R-mediated pathway involving destabilization of ERRα protein in selected cancer cell lines. British Journal of Pharmacology © 2011 The British Pharmacological Society. Published 2011. This article is a U.S. Government work and is in the public domain in the USA. JF - British journal of pharmacology AU - Fiori, J L AU - Sanghvi, M AU - O'Connell, M P AU - Krzysik-Walker, S M AU - Moaddel, R AU - Bernier, M AD - Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 1026 EP - 1040 VL - 164 IS - 3 KW - ERRalpha estrogen-related receptor KW - 0 KW - HBEGF protein, human KW - Hbegf protein, mouse KW - Heparin-binding EGF-like Growth Factor KW - Intercellular Signaling Peptides and Proteins KW - Ligands KW - Nitriles KW - Orphan Nuclear Receptors KW - Piperidines KW - Pyrazoles KW - RNA, Messenger KW - Receptor, Cannabinoid, CB1 KW - Receptors, Estrogen KW - Thiazoles KW - XCT790 KW - AM 251 KW - 3I4FA44MAI KW - Epidermal Growth Factor KW - 62229-50-9 KW - Genistein KW - DH2M523P0H KW - EGFR protein, human KW - EC 2.7.10.1 KW - Receptor, Epidermal Growth Factor KW - biochanin A KW - U13J6U390T KW - Index Medicus KW - Orphan Nuclear Receptors -- metabolism KW - Nitriles -- pharmacology KW - Humans KW - Cell Line, Tumor KW - HCT116 Cells KW - RNA, Messenger -- genetics KW - Protein Binding KW - RNA, Messenger -- biosynthesis KW - Thiazoles -- pharmacology KW - Intercellular Signaling Peptides and Proteins -- genetics KW - Genistein -- pharmacology KW - Up-Regulation -- drug effects KW - Epidermal Growth Factor -- metabolism KW - Intercellular Signaling Peptides and Proteins -- metabolism KW - Receptors, Estrogen -- antagonists & inhibitors KW - Piperidines -- pharmacology KW - Pyrazoles -- pharmacology KW - Receptor, Epidermal Growth Factor -- metabolism KW - Receptor, Epidermal Growth Factor -- genetics KW - Receptor, Cannabinoid, CB1 -- metabolism KW - Receptors, Estrogen -- metabolism KW - Receptors, Estrogen -- agonists KW - Receptor, Epidermal Growth Factor -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888338721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+pharmacology&rft.atitle=The+cannabinoid+receptor+inverse+agonist+AM251+regulates+the+expression+of+the+EGF+receptor+and+its+ligands+via+destabilization+of+oestrogen-related+receptor+%CE%B1+protein.&rft.au=Fiori%2C+J+L%3BSanghvi%2C+M%3BO%27Connell%2C+M+P%3BKrzysik-Walker%2C+S+M%3BMoaddel%2C+R%3BBernier%2C+M&rft.aulast=Fiori&rft.aufirst=J&rft.date=2011-10-01&rft.volume=164&rft.issue=3&rft.spage=1026&rft.isbn=&rft.btitle=&rft.title=British+journal+of+pharmacology&rft.issn=1476-5381&rft_id=info:doi/10.1111%2Fj.1476-5381.2011.01384.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-19 N1 - Date created - 2011-09-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Endocrinol. 2008 Mar;22(3):570-84 [18063693] Growth Horm IGF Res. 2008 Oct;18(5):424-33 [18424208] Anal Chem. 2008 Oct 1;80(19):7571-5 [18693748] Mol Cell Biol. 2008 Nov;28(22):6785-95 [18794372] Mini Rev Med Chem. 2008 Nov;8(13):1418-28 [18991757] J Biochem. 2009 Jan;145(1):13-20 [18845565] Nat Protoc. 2009;4(2):197-205 [19180089] Cell Mol Life Sci. 2009 Mar;66(5):773-87 [19011757] Cancer Metastasis Rev. 2009 Jun;28(1-2):151-66 [19153669] J Biol Chem. 2009 May 1;284(18):12328-38 [19286662] J Cell Physiol. 2009 Jul;220(1):35-44 [19347870] J Steroid Biochem Mol Biol. 2009 Mar;114(1-2):106-12 [19429439] Mol Cell Biol. 2009 Aug;29(15):4091-102 [19451226] Mol Cell Endocrinol. 2010 Feb 5;315(1-2):314-8 [19822186] Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1210-8 [20215575] J Pharm Biomed Anal. 2010 Nov 2;53(3):777-80 [20542653] World J Gastroenterol. 2004 Mar 15;10(6):860-3 [15040033] FEBS Lett. 1999 Sep 24;458(3):400-4 [10570948] Endocrinology. 2000 Jan;141(1):118-26 [10614630] Cell. 2000 Jan 7;100(1):57-70 [10647931] Br J Pharmacol. 2000 Jan;129(2):227-30 [10694225] Cancer. 2000 May 1;88(9):2000-9 [10813710] Br J Cancer. 2001 Apr 6;84(7):926-35 [11286473] Genes Dev. 2001 Apr 1;15(7):833-8 [11297507] Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8880-4 [11447273] Biochem Biophys Res Commun. 2001 Sep 7;286(5):1144-52 [11527419] Endocrinology. 2001 Oct;142(10):4572-5 [11564725] Eur J Cancer. 2001 Sep;37 Suppl 4:S9-15 [11597399] Eur J Pharmacol. 2001 Jul 27;424(3):211-9 [11672565] Hypertension. 2002 Feb;39(2):251-7 [11847193] Cancer Res. 2002 Nov 15;62(22):6510-8 [12438245] Prostate. 2003 Jun 15;56(1):1-12 [12746841] Oncogene. 2003 Jul 31;22(31):4875-81 [12894229] Mol Cell Biol. 2003 Nov;23(22):7947-56 [14585956] Biochem Biophys Res Commun. 2004 Feb 20;314(4):964-70 [14751226] Cancer Res. 2004 Mar 15;64(6):1943-50 [15026328] Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6472-7 [15087503] Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8912-7 [15184675] Cancer Res. 2004 Jul 1;64(13):4670-6 [15231680] Mol Pharmacol. 2004 Aug;66(2):204-8 [15266010] Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H595-600 [15059774] Mol Cell Biol. 2004 Oct;24(20):9079-91 [15456881] J Med Chem. 2004 Nov 4;47(23):5593-6 [15509154] J Neurosci. 1991 Feb;11(2):563-83 [1992016] J Comp Neurol. 1993 Jan 22;327(4):535-50 [8440779] Prostate. 1993;22(4):335-45 [8497428] Proc Soc Exp Biol Med. 1993 Oct;204(1):110-6 [8372093] Cytometry. 1995 May 1;20(1):43-52 [7600899] Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6981-5 [7542783] Cell Growth Differ. 1998 Dec;9(12):1007-14 [9869301] J Neurosci. 2005 Jan 19;25(3):662-71 [15659603] Cancer Res. 2005 Mar 1;65(5):1635-41 [15753356] Lancet. 2005 Apr 16-22;365(9468):1389-97 [15836887] J Mol Med (Berl). 2005 Jun;83(6):457-67 [15770498] Eur J Cancer. 2005 Jul;41(10):1487-94 [15949936] Behav Pharmacol. 2005 Sep;16(5-6):405-13 [16148445] Endocrinology. 2005 Oct;146(10):4292-301 [15994343] Gut. 2005 Dec;54(12):1741-50 [16099783] Mol Cell Biol. 2005 Dec;25(24):10684-94 [16314495] J Med Food. 2005 Winter;8(4):431-8 [16379552] PLoS Med. 2005 Nov;2(11):e313 [16187797] Curr Top Med Chem. 2006;6(3):203-15 [16515477] Gut. 2006 Apr;55(4):519-28 [16174661] Cancer Res. 2006 Jul 1;66(13):6615-21 [16818634] Endocr Relat Cancer. 2006 Dec;13 Suppl 1:S25-32 [17259555] Biochemistry. 2007 Aug 28;46(34):9795-804 [17676930] Biochem Biophys Res Commun. 2007 Nov 3;362(4):928-34 [17765871] J Biol Chem. 2007 Sep 28;282(39):28328-34 [17631492] Front Biosci. 2008;13:1857-65 [17981673] Br J Pharmacol. 2007 Dec;152(7):1092-101 [17876302] Mol Cell. 2007 Dec 14;28(5):730-8 [18082598] Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2699-704 [18263732] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1476-5381.2011.01384.x ER - TY - JOUR T1 - Computational strategy for tuning spectral properties of red fluorescent proteins. AN - 879101881; 21652139 AB - Computational methods of quantum chemistry are used to characterize structures and vertical excitation energies of the S(0)-S(1) optical transitions in the chromophore binding pockets of the red fluorescent proteins DsRed and of its artificial mutant mCherry. As previously shown, optimizing the equilibrium geometry configurations with B3LYP density functional theory, followed by ZINDO calculations of the electronic excitations, yields positions of the optical bands in good agreement with experimental data. These large scale quantum calculations elucidate the role of the hydrogen bonded network as well as point mutations in the absorption spectra of the DsRed and mCherry proteins. The effect of an external electric field applied to the fluorescent protein chromophores is examined and shows that such fields may result in large shifts in spectral bands. These strategies can be applied for rational design of the fluorescent proteins by site-directed mutagenesis. Copyright © 2011 Elsevier B.V. All rights reserved. JF - Biophysical chemistry AU - Topol, I AU - Collins, J AU - Savitsky, A AU - Nemukhin, A AD - Advanced Biomedical Computing Center, Information Systems Program, SAIC- Frederick Inc., NCI-Frederick, MD 21702-1201, USA. topoli@mail.nih.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 91 EP - 95 VL - 158 IS - 2-3 KW - Luminescent Proteins KW - 0 KW - red fluorescent protein KW - Index Medicus KW - Quantum Theory KW - Animals KW - Models, Molecular KW - Point Mutation KW - Electricity KW - Protein Conformation KW - Binding Sites KW - Anthozoa -- chemistry KW - Luminescent Proteins -- chemistry KW - Luminescent Proteins -- genetics KW - Anthozoa -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879101881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biophysical+chemistry&rft.atitle=Computational+strategy+for+tuning+spectral+properties+of+red+fluorescent+proteins.&rft.au=Topol%2C+I%3BCollins%2C+J%3BSavitsky%2C+A%3BNemukhin%2C+A&rft.aulast=Topol&rft.aufirst=I&rft.date=2011-10-01&rft.volume=158&rft.issue=2-3&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Biophysical+chemistry&rft.issn=1873-4200&rft_id=info:doi/10.1016%2Fj.bpc.2011.05.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-08 N1 - Date created - 2011-07-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bpc.2011.05.016 ER - TY - JOUR T1 - Microarray analysis of sexually dimorphic gene expression in human minor salivary glands AN - 1399905117; 15995122 AB - Objective: We hypothesized that differential mRNA transcription between the sexes may be linked to the 9:1 female-to-male gender-related relative risk for the development of Sjogren's syndrome (SS), an autoimmune disease that leads to inflammation and dysfunction in the lachrymal and salivary glands. Subjects and Methods: RNA from minor salivary glands was collected from nine healthy volunteers (four men and five women) and analyzed using the Agilent 444K human microarray platform. Differential expression was confirmed by qRT-PCR. Results: Comparison of the transcriptome of minor salivary glands from normal male and female volunteers with that of salivary glands and secretory epithelia identified a number of gender, species, and tissue-specific gene expression patterns. These differences include, but are not limited to, a diverse set of genes involved in immune modulation, chemotactic control, inhibition of complement, metabolism, and neurogenesis. Conclusion: Analysis of these changes provides insight into the protective and predisposing molecular factors that may be involved in the development of Sjogren's syndrome. Some of the gene changes observed in this study correlate with previously observed sexual dimorphisms in salivary gland function and also illustrate several new targets for further investigation.Original Abstract: Oral Diseases (2011) 17, 653-661 JF - Oral Diseases AU - Michael, D AU - Soi, S AU - Cabera-Perez, J AU - Weller, M AU - Alexander, S AU - Alevizos, I AU - Illei, G G AU - Chiorini, JA AD - Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Center Drive, MD, USA Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 653 EP - 661 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 17 IS - 7 SN - 1354-523X, 1354-523X KW - Biotechnology and Bioengineering Abstracts KW - Risk assessment KW - Sexual dimorphism KW - Autoimmune diseases KW - Transcription KW - Salivary gland KW - Immunomodulation KW - DNA microarrays KW - Inflammation KW - Sjogren's syndrome KW - Gene expression KW - Neurogenesis KW - Metabolism KW - Sex KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1399905117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oral+Diseases&rft.atitle=Microarray+analysis+of+sexually+dimorphic+gene+expression+in+human+minor+salivary+glands&rft.au=Michael%2C+D%3BSoi%2C+S%3BCabera-Perez%2C+J%3BWeller%2C+M%3BAlexander%2C+S%3BAlevizos%2C+I%3BIllei%2C+G+G%3BChiorini%2C+JA&rft.aulast=Michael&rft.aufirst=D&rft.date=2011-10-01&rft.volume=17&rft.issue=7&rft.spage=653&rft.isbn=&rft.btitle=&rft.title=Oral+Diseases&rft.issn=1354523X&rft_id=info:doi/10.1111%2Fj.1601-0825.2011.01816.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-07-01 N1 - Document feature - figure 4 N1 - Last updated - 2013-08-12 N1 - SubjectsTermNotLitGenreText - Risk assessment; Sexual dimorphism; Autoimmune diseases; Transcription; Salivary gland; DNA microarrays; Immunomodulation; Inflammation; Gene expression; Sjogren's syndrome; Neurogenesis; Metabolism; Sex DO - http://dx.doi.org/10.1111/j.1601-0825.2011.01816.x ER - TY - JOUR T1 - Erionite exposure in North Dakota and in the turkish villages with mesothelioma AN - 1356356684; 2013-041950 AB - Exposure to erionite, an asbestos-like mineral, causes unprecedented rates of malignant mesothelioma (MM) mortality in some Turkish villages. Erionite deposits are present in at least 12 US States. We investigated whether increased urban development has led to erionite exposure in the US and after preliminary exploration, focused our studies on Dunn County, North Dakota (ND). In Dunn County, ND we discovered that over the past 3 decades, more than 300 miles of roads were surfaced with erionite-containing gravel. To determine potential health implications, we compared erionite from the Turkish villages to that from ND. Our study evaluated airborne point exposure concentrations, examined the physical and chemical properties of erionite, and examined the hallmarks of mesothelial cell transformation in vitro and in vivo. Airborne erionite concentrations measured in ND along roadsides, indoors and inside vehicles, including school buses, equaled or exceeded concentrations in Boyali, where 6.25% of all deaths are caused by MM. With the exception of outdoor samples along roadsides, ND concentrations were lower than those measured in Turkish villages with MM-mortality ranging from 20-50%. The physical and chemical properties of erionite from Turkey and ND are very similar and they showed identical biological activities. Considering the known 30-60 years latency for MM development, there is reason for concern for increased risk in ND in the future. Our findings indicate that implementation of novel preventive and early detection programs in ND and other erionite-rich areas of the US, similar to efforts currently being undertaken in Turkey, is warranted. JF - Abstracts with Programs - Geological Society of America AU - Carbone, Michele AU - Yang, Haining AU - Brass, Brian AU - Dogan, Ahmet Umran AU - Partridge, Charles R AU - Pass, Harvey I AU - Steele, Ian M AU - Tuncer, Murat AU - Way, Steve AU - Miller, Aubrey AU - Anonymous Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 418 PB - Geological Society of America (GSA), Boulder, CO VL - 43 IS - 5 SN - 0016-7592, 0016-7592 KW - United States KW - silicates KW - erionite KW - pollutants KW - Turkey KW - pollution KW - North Dakota KW - toxicity KW - zeolite group KW - mesothelioma KW - framework silicates KW - Asia KW - Middle East KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1356356684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Erionite+exposure+in+North+Dakota+and+in+the+turkish+villages+with+mesothelioma&rft.au=Carbone%2C+Michele%3BYang%2C+Haining%3BBrass%2C+Brian%3BDogan%2C+Ahmet+Umran%3BPartridge%2C+Charles+R%3BPass%2C+Harvey+I%3BSteele%2C+Ian+M%3BTuncer%2C+Murat%3BWay%2C+Steve%3BMiller%2C+Aubrey%3BAnonymous&rft.aulast=Carbone&rft.aufirst=Michele&rft.date=2011-10-01&rft.volume=43&rft.issue=5&rft.spage=418&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2011 annual meeting N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2013-01-01 N1 - PubXState - CO N1 - Last updated - 2013-05-30 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - Asia; erionite; framework silicates; mesothelioma; Middle East; North Dakota; pollutants; pollution; silicates; toxicity; Turkey; United States; zeolite group ER - TY - JOUR T1 - Coiled-coil domains enhance the membrane association of Salmonella type III effectors AN - 1348481052; 15929323 AB - Coiled-coil domains in eukaryotic and prokaryotic proteins contribute to diverse structural and regulatory functions. Here we have used in silico analysis to predict which proteins in the proteome of the enteric pathogen, Salmonella enterica serovar Typhimurium, harbour coiled-coil domains. We found that coiled-coil domains are especially prevalent in virulence-associated proteins, including type III effectors. Using SopB as a model coiled-coil domain type III effector, we have investigated the role of this motif in various aspects of effector function including chaperone binding, secretion and translocation, protein stability, localization and biological activity. Compared with wild-type SopB, SopB coiled-coil mutants were unstable, both inside bacteria and after translocation into host cells. In addition, the putative coiled-coil domain was required for the efficient membrane association of SopB in host cells. Since many other Salmonella effectors were predicted to contain coiled-coil domains, we also investigated the role of this motif in their intracellular targeting in mammalian cells. Mutation of the predicted coiled-coil domains in PipB2, SseJ and SopD2 also eliminated their membrane localization in mammalian cells. These findings suggest that coiled-coil domains represent a common membrane-targeting determinant for Salmonella type III effectors. JF - Cellular Microbiology AU - Knodler, Leigh A AU - Ibarra, JAntonio AU - Perez-Rueda, Ernesto AU - Yip, Calvin K AU - Steele-Mortimer, Olivia AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, USA Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1497 EP - 1517 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 13 IS - 10 SN - 1462-5814, 1462-5814 KW - Microbiology Abstracts B: Bacteriology KW - Protein transport KW - Mammalian cells KW - Salmonella enterica KW - Secretion KW - Chaperones KW - Pathogens KW - Mutation KW - Translocation KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1348481052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Microbiology&rft.atitle=Coiled-coil+domains+enhance+the+membrane+association+of+Salmonella+type+III+effectors&rft.au=Knodler%2C+Leigh+A%3BIbarra%2C+JAntonio%3BPerez-Rueda%2C+Ernesto%3BYip%2C+Calvin+K%3BSteele-Mortimer%2C+Olivia&rft.aulast=Knodler&rft.aufirst=Leigh&rft.date=2011-10-01&rft.volume=13&rft.issue=10&rft.spage=1497&rft.isbn=&rft.btitle=&rft.title=Cellular+Microbiology&rft.issn=14625814&rft_id=info:doi/10.1111%2Fj.1462-5822.2011.01635.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Document feature - figure 8 N1 - Last updated - 2013-05-17 N1 - SubjectsTermNotLitGenreText - Protein transport; Mammalian cells; Secretion; Chaperones; Pathogens; Translocation; Mutation; Salmonella enterica DO - http://dx.doi.org/10.1111/j.1462-5822.2011.01635.x ER - TY - JOUR T1 - Magnetic Resonance Imaging/Ultrasound Fusion Guided Prostate Biopsy Improves Cancer Detection Following Transrectal Ultrasound Biopsy and Correlates With Multiparametric Magnetic Resonance Imaging AN - 1238122542; 15796452 AB - Purpose: A novel platform was developed that fuses pre-biopsy magnetic resonance imaging with real-time transrectal ultrasound imaging to identify and biopsy lesions suspicious for prostate cancer. The cancer detection rates for the first 101 patients are reported. Materials and Methods: This prospective, single institution study was approved by the institutional review board. Patients underwent 3.0 T multiparametric magnetic resonance imaging with endorectal coil, which included T2-weighted, spectroscopic, dynamic contrast enhanced and diffusion weighted magnetic resonance imaging sequences. Lesions suspicious for cancer were graded according to the number of sequences suspicious for cancer as low (2 or less), moderate (3) and high (4) suspicion. Patients underwent standard 12-core transrectal ultrasound biopsy and magnetic resonance imaging/ultrasound fusion guided biopsy with electromagnetic tracking of magnetic resonance imaging lesions. Chi-square and within cluster resampling analyses were used to correlate suspicion on magnetic resonance imaging and the incidence of cancer detected on biopsy. Results: Mean patient age was 63 years old. Median prostate specific antigen at biopsy was 5.8 ng/ml and 90.1% of patients had a negative digital rectal examination. Of patients with low, moderate and high suspicion on magnetic resonance imaging 27.9%, 66.7% and 89.5% were diagnosed with cancer, respectively (p 0.0001). Magnetic resonance imaging/ultrasound fusion guided biopsy detected more cancer per core than standard 12-core transrectal ultrasound biopsy for all levels of suspicion on magnetic resonance imaging. Conclusions: Prostate cancer localized on magnetic resonance imaging may be targeted using this novel magnetic resonance imaging/ultrasound fusion guided biopsy platform. Further research is needed to determine the role of this platform in cancer detection, active surveillance and focal therapy, and to determine which patients may benefit. JF - Journal of Urology AU - Pinto, Peter A AU - Chung, Paul H AU - Rastinehad, Ardeshir R AU - Baccala, Angelo A AU - Kruecker, Jochen AU - Benjamin, Compton J AU - Xu, Sheng AU - Yan, Pingkun AU - Kadoury, Samuel AU - Chua, Celene AU - Locklin, Julia K AU - Turkbey, Baris AU - Shih, Joanna H AU - Gates, Stacey P AU - Buckner, Carey AU - Bratslavsky, Gennady AU - Linehan, WMarston AU - Glossop, Neil D AU - Choyke, Peter L AU - Wood, Bradford J AD - Urologic Oncology Branch, Center for Cancer Research, Clinical Center & National Cancer Institute, National Institutes of Health, Bethesda, Maryland, pintop@mail.nih.gov Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1281 EP - 1285 PB - Elsevier B.V. VL - 186 IS - 4 SN - 0022-5347, 0022-5347 KW - Biotechnology and Bioengineering Abstracts KW - Age KW - Biopsy KW - Diffusion KW - Magnetic resonance imaging KW - Prostate cancer KW - Rectum KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1238122542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Urology&rft.atitle=Magnetic+Resonance+Imaging%2FUltrasound+Fusion+Guided+Prostate+Biopsy+Improves+Cancer+Detection+Following+Transrectal+Ultrasound+Biopsy+and+Correlates+With+Multiparametric+Magnetic+Resonance+Imaging&rft.au=Pinto%2C+Peter+A%3BChung%2C+Paul+H%3BRastinehad%2C+Ardeshir+R%3BBaccala%2C+Angelo+A%3BKruecker%2C+Jochen%3BBenjamin%2C+Compton+J%3BXu%2C+Sheng%3BYan%2C+Pingkun%3BKadoury%2C+Samuel%3BChua%2C+Celene%3BLocklin%2C+Julia+K%3BTurkbey%2C+Baris%3BShih%2C+Joanna+H%3BGates%2C+Stacey+P%3BBuckner%2C+Carey%3BBratslavsky%2C+Gennady%3BLinehan%2C+WMarston%3BGlossop%2C+Neil+D%3BChoyke%2C+Peter+L%3BWood%2C+Bradford+J&rft.aulast=Pinto&rft.aufirst=Peter&rft.date=2011-10-01&rft.volume=186&rft.issue=4&rft.spage=1281&rft.isbn=&rft.btitle=&rft.title=Journal+of+Urology&rft.issn=00225347&rft_id=info:doi/10.1016%2Fj.juro.2011.05.078 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-12-01 N1 - Last updated - 2012-12-28 N1 - SubjectsTermNotLitGenreText - Age; Rectum; Prostate cancer; Magnetic resonance imaging; Diffusion; Biopsy; Ultrasound DO - http://dx.doi.org/10.1016/j.juro.2011.05.078 ER - TY - JOUR T1 - The Cochrane Students Journal Club and Creating a Secondary Learning Resource for Gathering and Appraising Evidence: An Example of Rational Use of Medicines to Prevent Malaria Relapse AN - 1238109572; 17298076 AB - In the current era of evidence-based healthcare, online learning resources provide accessible and affordable training and teaching resources to stimulate the next generation of medical professionals. In the first of a series of qualitative case studies on the Cochrane student's journal club, the authors evaluate and portray the outcomes in each of its patient-focused, evidence-based learning activities. This study illustrates an exercise centered on the hypothetical case of a patient treated for Plasmodium vivax presenting with a suspected relapse. JF - International Journal of User-Driven Healthcare AU - Chandra, Shivika AU - Shah, Naman K AU - Sriganesh, Vasumathi AD - National Institute of Mental Health and Neurosciences, India Y1 - 2011/10/01/ PY - 2011 DA - 2011 Oct 01 SP - 31 EP - 41 PB - IGI Global, 701 E. Chocolate Ave. Hershey PA 17033 VL - 1 IS - 4 SN - 2156-1818, 2156-1818 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Learning KW - Education KW - Human diseases KW - Plasmodium vivax KW - Medicine KW - Malaria KW - Experts KW - Internet KW - Physical training KW - Public health KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1238109572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+User-Driven+Healthcare&rft.atitle=The+Cochrane+Students+Journal+Club+and+Creating+a+Secondary+Learning+Resource+for+Gathering+and+Appraising+Evidence%3A+An+Example+of+Rational+Use+of+Medicines+to+Prevent+Malaria+Relapse&rft.au=Chandra%2C+Shivika%3BShah%2C+Naman+K%3BSriganesh%2C+Vasumathi&rft.aulast=Chandra&rft.aufirst=Shivika&rft.date=2011-10-01&rft.volume=1&rft.issue=4&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+User-Driven+Healthcare&rft.issn=21561818&rft_id=info:doi/10.4018%2Fijudh.2011100103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-12-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Human diseases; Education; Experts; Malaria; Medicine; Public health; Learning; Internet; Physical training; Plasmodium vivax DO - http://dx.doi.org/10.4018/ijudh.2011100103 ER - TY - JOUR T1 - Giving Care to Men and Women with Mental Illness AN - 1037877409; 201205912 AB - Caregivers are a largely understudied, unsung population who shoulder many of the social and psychological costs of mental illness. This study examines the load of caregiving during symptomatic and stabilised phases of the mentally ill and the various ways in which family members adapt themselves to give care. Drawing its data from 200 families with mental illness in Andhra Pradesh and Karnataka, the study diffuses the notion of care as physical, medical, psychological and social. The article focuses on how the gender of the affected person affects caregiving and underlines the indispensability of the family. Used to giving credit for any improvement to doctors and medicines, the study records the incredulous gratitude of caregivers at being acknowledged for the work they do, providing a boost to the morale of tired, unacknowledged caregivers. [Reprinted by permission of Sage Publications Ltd., copyright holder.] JF - Indian Journal of Gender Studies AU - Janardhana, N AU - Shravya, R AU - Naidu, D M AU - Saraswathy, L AU - Seshan, Valli AD - Psychiatric Social Work, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 405 EP - 424 PB - Sage Publications, New Delhi India VL - 18 IS - 3 SN - 0971-5215, 0971-5215 KW - Caregivers caring for the mentally ill gender and caregiving KW - Caregivers KW - Family KW - Medicine KW - Physicians KW - Mental Illness KW - Sex KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1037877409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+Journal+of+Gender+Studies&rft.atitle=Giving+Care+to+Men+and+Women+with+Mental+Illness&rft.au=Janardhana%2C+N%3BShravya%2C+R%3BNaidu%2C+D+M%3BSaraswathy%2C+L%3BSeshan%2C+Valli&rft.aulast=Janardhana&rft.aufirst=N&rft.date=2011-10-01&rft.volume=18&rft.issue=3&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Indian+Journal+of+Gender+Studies&rft.issn=09715215&rft_id=info:doi/10.1177%2F097152151101800306 LA - English DB - Social Services Abstracts N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-09-28 N1 - CODEN - IJGSF4 N1 - SubjectsTermNotLitGenreText - Caregivers; Family; Mental Illness; Physicians; Sex; Medicine DO - http://dx.doi.org/10.1177/097152151101800306 ER - TY - JOUR T1 - A 400-year record of black carbon flux in the Xisha Archipelago, South China Sea and its implication AN - 1037241022; 2012-078026 AB - We reconstructed the first long-term ( nearly equal 400 years) records of black carbon (BC) deposition flux from three ornithogenic sediment profiles, which were collected from three remote, isolated islets of the Xisha archipelago, South China Sea. The significant correlations between black carbon, organic matter and excess (super 210) Pb suggested that black carbon was mainly derived from atmospheric deposition, and further enriched by plant-derived organic matter in sediments. During the past 400 years, the BC flux remained relatively low before the onset of 20th century; it started to increase from approximately 1900 AD, and peaked around the 1970s. In the recent 30 years, the BC flux seemed to display decreasing trend, very likely due to the change of energy structure and development of pollution control techniques. In comparison with marginal sea regions that are greatly impacted by anthropogenic activities, these pristine Xisha islands were not significantly influenced by black carbon of anthropogenic origin. JF - Marine Pollution Bulletin AU - Liu, Xiaodong AU - Xu, Liqinag AU - Sun, Liguang AU - Liu, Fei AU - Wang, Yuhong AU - Yan, Hong AU - Liu, Yi AU - Luo, Yuhan AU - Huang, Jing Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 2205 EP - 2212 PB - Elsevier, Oxford VL - 62 IS - 10 SN - 0025-326X, 0025-326X KW - Far East KW - isotopes KW - Xisha Islands KW - lead KW - environmental effects KW - cores KW - West Pacific KW - Ra-226 KW - radioactive isotopes KW - cesium KW - black carbon KW - total organic carbon KW - sediments KW - absolute age KW - Northwest Pacific KW - Asia KW - South China Sea KW - China KW - alkaline earth metals KW - radium KW - human activity KW - alkali metals KW - pollution KW - organic compounds KW - Cs-137 KW - North Pacific KW - metals KW - Pacific Ocean KW - Pb-210 KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1037241022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Pollution+Bulletin&rft.atitle=A+400-year+record+of+black+carbon+flux+in+the+Xisha+Archipelago%2C+South+China+Sea+and+its+implication&rft.au=Liu%2C+Xiaodong%3BXu%2C+Liqinag%3BSun%2C+Liguang%3BLiu%2C+Fei%3BWang%2C+Yuhong%3BYan%2C+Hong%3BLiu%2C+Yi%3BLuo%2C+Yuhan%3BHuang%2C+Jing&rft.aulast=Liu&rft.aufirst=Xiaodong&rft.date=2011-10-01&rft.volume=62&rft.issue=10&rft.spage=2205&rft.isbn=&rft.btitle=&rft.title=Marine+Pollution+Bulletin&rft.issn=0025326X&rft_id=info:doi/10.1016%2Fj.marpolbul.2011.06.027 L2 - http://www.sciencedirect.com/science/journal/0025326X LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2012-01-01 N1 - Number of references - 52 N1 - Document feature - illus. incl. 1 table, sketch map N1 - Last updated - 2012-08-31 N1 - CODEN - MPNBAZ N1 - SubjectsTermNotLitGenreText - absolute age; alkali metals; alkaline earth metals; Asia; black carbon; cesium; China; cores; Cs-137; environmental effects; Far East; human activity; isotopes; lead; metals; North Pacific; Northwest Pacific; organic compounds; Pacific Ocean; Pb-210; pollution; Ra-226; radioactive isotopes; radium; sediments; South China Sea; total organic carbon; West Pacific; Xisha Islands DO - http://dx.doi.org/10.1016/j.marpolbul.2011.06.027 ER - TY - JOUR T1 - Understanding Patterns of Health Communication in Families at Risk for Hereditary Nonpolyposis Colorectal Cancer: Examining the Effect of Conclusive Versus Indeterminate Genetic Test Results AN - 1030903819; 201220308 AB - In families meeting criteria for hereditary nonpolyposis colorectal cancer (HNPCC), genetic testing may or may not identify a mutation. Communication about genetic testing and risk in families with identified HNPCC mutations is associated with individual and relational factors. Similar communication patterns would be expected in families with similar clinical and pathological characteristics, but without an identified HNPCC mutation; however, previous studies have not included such families. Social network analysis was used to compare communication networks and associated individual and relational factors in families with and without identified HNPCC mutations. Respondents from families without identified mutations communicated about genetic counseling and testing and risk for HNPCC with a significantly smaller proportion of network members, compared to respondents from mutation-positive families. Members of families without identified mutations were also more likely to share thoughts about risk for HNPCC with network members whose advice they take, compared to members of families with known mutations. These findings extend our knowledge of communication in families at risk of HNPCC to include the many families in which a causative mutation has not yet been identified. Differences in the breadth of communication about genetics and risk for HNPCC, and the possibility that members of families without identified mutations may seek advice from those with whom they communicate about risk, provide new avenues for future research. Understanding existing communication patterns could help improve education and counseling processes, and facilitate the development of interventions designed to assist in family discussions of risk. Adapted from the source document. JF - Health Communication AU - Ersig, Anne L AU - Hadley, Donald W AU - Koehly, Laura M AD - College of Nursing, University of Iowa, National Human Genome Research Institute, National Institute of Nursing Research, National Institutes of Health Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 587 EP - 594 PB - Taylor & Francis Group, Philadelphia PA VL - 26 IS - 7 SN - 1041-0236, 1041-0236 KW - Social networks KW - Colorectal cancer KW - Genetic screening KW - Health information KW - Communication style KW - At risk KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1030903819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Communication&rft.atitle=Understanding+Patterns+of+Health+Communication+in+Families+at+Risk+for+Hereditary+Nonpolyposis+Colorectal+Cancer%3A+Examining+the+Effect+of+Conclusive+Versus+Indeterminate+Genetic+Test+Results&rft.au=Ersig%2C+Anne+L%3BHadley%2C+Donald+W%3BKoehly%2C+Laura+M&rft.aulast=Ersig&rft.aufirst=Anne&rft.date=2011-10-01&rft.volume=26&rft.issue=7&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=Health+Communication&rft.issn=10410236&rft_id=info:doi/10.1080%2F10410236.2011.558338 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-08-01 N1 - Last updated - 2016-09-27 N1 - CODEN - HECOER N1 - SubjectsTermNotLitGenreText - Genetic screening; At risk; Colorectal cancer; Communication style; Social networks; Health information DO - http://dx.doi.org/10.1080/10410236.2011.558338 ER - TY - JOUR T1 - Trait dissociation and the subjective affective, motivational, and phenomenological experience of self-defining memories AN - 1024211450; 4310912 AB - The present research reports 2 studies that examine the relation between nonpathological trait dissociation and the subjective affect, motivation, and phenomenology of self-defining memories. In Study 1 (N=293), participants retrieved and rated the emotional and motivational experience of a general and a positive and negative achievement-related memory. Study 2 (N=449) extended these ratings to relationship-related memories and the phenomenological experience of the memory. Dissociation was associated with incongruent affect in valenced memories (e.g., positive affect in a negative memory) and memories that were visually incoherent and saturated with power motivation, hubristic pride, and shame, regardless of valence or domain. The present findings demonstrate that autobiographical memories, which integrate emotional, motivational, and phenomenological components, reflect the emotional and motivational processes inherent to dissociation. Adapted from the source document. Reprinted by permission of Blackwell Publishers JF - Journal of personality AU - Sutin, Angelina R AU - Stockdale, Gary D AD - National Institute on Aging Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 939 EP - 964 VL - 79 IS - 5 SN - 0022-3506, 0022-3506 KW - Sociology KW - Pride KW - Subjectivity KW - Emotions KW - Memory KW - Autobiography KW - Motivation KW - Personality traits KW - Self KW - Phenomenology KW - Honour and shame UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1024211450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality&rft.atitle=Trait+dissociation+and+the+subjective+affective%2C+motivational%2C+and+phenomenological+experience+of+self-defining+memories&rft.au=Sutin%2C+Angelina+R%3BStockdale%2C+Gary+D&rft.aulast=Sutin&rft.aufirst=Angelina&rft.date=2011-10-01&rft.volume=79&rft.issue=5&rft.spage=939&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality&rft.issn=00223506&rft_id=info:doi/10.1111%2Fj.1467-6494.2010.00708.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4196; 8322; 12347; 9478 9485 9486; 7930; 11442 6191; 1414 1604 7464; 10129; 5976; 9429 9416 2153 DO - http://dx.doi.org/10.1111/j.1467-6494.2010.00708.x ER - TY - JOUR T1 - Cognitive behavior therapy in medication non-responders with obsessive-compulsive disorder: A prospective 1-year follow-up study AN - 1023091247; 201212466 AB - Evidence of efficacy of cognitive behavior therapy (CBT) in obsessive-compulsive disorder (OCD) non-responsive to multiple trials of serotonin reuptake inhibitors (SRI) is limited. We examined the efficacy of CBT in 31 adult patients with DSM-IV OCD who were non-responders to at least two SRI trials. They received 20-25 sessions of CBT over 3-month duration. The primary outcome measure was "response" to treatment [Clinical Global Impressions-Improvement score 1 or 2 and =35% reduction in Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) severity score]. Patients were assessed at baseline, post-treatment and at 3-, 6- and 12-month follow-up. Twenty-six (84%) patients completed treatment and number of responders at post-treatment, 3-, 6- and 12-month follow-up were 23 (74%), 20 (64%), 20 (64%) and 19 (61%) respectively. Quality of homework compliance and baseline Y-BOCS severity predicted remission (Y-BOCS < 16) to CBT. CBT is useful in OCD non-responsive to multiple trials of SRI. [Copyright Elsevier B.V.] JF - Journal of Anxiety Disorders AU - Anand, Nitin AU - Sudhir, Paulomi M AU - Math, Suresh Bada AU - Thennarasu, K AU - Reddy, Y C Janardhan AD - Department of Clinical Psychology, National Institute of Mental Health & Neuro Sciences, India Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 939 EP - 945 PB - Elsevier Ltd, The Netherlands VL - 25 IS - 7 SN - 0887-6185, 0887-6185 KW - Obsessive-compulsive disorder KW - Cognitive-behavior therapy KW - SRI non-response KW - Cognitive behaviour therapy KW - Severity KW - Efficacy KW - Compliance KW - Remission KW - Obsessive-Compulsive neuroses KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023091247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Anxiety+Disorders&rft.atitle=Cognitive+behavior+therapy+in+medication+non-responders+with+obsessive-compulsive+disorder%3A+A+prospective+1-year+follow-up+study&rft.au=Anand%2C+Nitin%3BSudhir%2C+Paulomi+M%3BMath%2C+Suresh+Bada%3BThennarasu%2C+K%3BReddy%2C+Y+C+Janardhan&rft.aulast=Anand&rft.aufirst=Nitin&rft.date=2011-10-01&rft.volume=25&rft.issue=7&rft.spage=939&rft.isbn=&rft.btitle=&rft.title=Journal+of+Anxiety+Disorders&rft.issn=08876185&rft_id=info:doi/10.1016%2Fj.janxdis.2011.05.007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Cognitive behaviour therapy; Obsessive-Compulsive neuroses; Severity; Efficacy; Compliance; Remission DO - http://dx.doi.org/10.1016/j.janxdis.2011.05.007 ER - TY - JOUR T1 - Criteria for Authorship in Bioethics AN - 1023035743; 2011-232448 AB - Multiple authorship is becoming increasingly common in bioethics research. There are well-established criteria for authorship in empirical bioethics research but not for conceptual research. It is important to develop criteria for authorship in conceptual publications to prevent undeserved authorship and uphold standards of fairness and accountability. This article explores the issue of multiple authorship in bioethics and develops criteria for determining who should be an author on a conceptual publication in bioethics. Authorship in conceptual research should be based on contributing substantially to: (1) identifying a topic, problem, or issue to study; (2) reviewing and interpreting the relevant literature; (3) formulating, analyzing, and evaluating arguments that support one or more theses; (4) responding to objections and counterarguments; and (5) drafting the manuscript and approving the final version. Authors of conceptual publications should participate substantially in at least two of areas (1)-(5). Adapted from the source document. JF - The American Journal of Bioethics AU - Resnik, David B AU - Master, Zubin AD - National Institute of Environmental Health Sciences Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 17 EP - 21 PB - Taylor & Francis, Philadelphia PA VL - 11 IS - 10 SN - 1526-5161, 1526-5161 KW - Culture and religion - Literature KW - Law and ethics - Ethics KW - accountability authorship guidelines bioethics conceptual publications fairness multiple authorship KW - Authorship KW - Bioethics KW - Standards KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023035743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Bioethics&rft.atitle=Criteria+for+Authorship+in+Bioethics&rft.au=Resnik%2C+David+B%3BMaster%2C+Zubin&rft.aulast=Resnik&rft.aufirst=David&rft.date=2011-10-01&rft.volume=11&rft.issue=10&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Bioethics&rft.issn=15265161&rft_id=info:doi/10.1080%2F15265161.2011.603795 LA - English DB - PAIS Index N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Authorship; Bioethics; Standards DO - http://dx.doi.org/10.1080/15265161.2011.603795 ER - TY - JOUR T1 - Helicobacter pylori and autoimmune diseases AN - 1020855945; 15995116 AB - Helicobacter pylori (H. pylori) is a widely prevalent microbe, with between 50 and 80% of the population infected worldwide. Clinically, infection with H. pylori is commonly associated with peptic ulcer disease, but many of those infected remain asymptomatic. H. pylori has evolved a number of means to affect the host immune response and has been implicated in many diseases mitigated by immune dysregulation, such as immune thrombocytopenic purpura (ITP), atrophic gastritis, and mucosa associated lymphoid tissue (MALT) lymphoma. Autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and Sjogren's syndrome, are the result of a dysregulated host immune system which targets otherwise healthy tissues. The exact etiology of autoimmune diseases is unclear, but it has long been suggested that exposure to certain environmental agents, such as viral and bacterial infection or chemical exposures, in genetically susceptible individuals may be the catalyst for the initiation of autoimmune processes. Because of its prevalence and ability to affect human immune function, many researchers have hypothesized that H. pylori might contribute to the development of autoimmune diseases. In this article, we review the available literature regarding the role of chronic H. pylori infection in various autoimmune disease states.Original Abstract: Oral Diseases (2011) 17, 621-627 JF - Oral Diseases AU - Hasni, S AU - Ippolito, A AU - Illei, G G AD - National Institute of Arthritis and Musculoskeletal and Skin Diseases Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 621 EP - 627 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 17 IS - 7 SN - 1354-523X, 1354-523X KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Helicobacter pylori KW - Autoimmune diseases KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020855945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oral+Diseases&rft.atitle=Helicobacter+pylori+and+autoimmune+diseases&rft.au=Hasni%2C+S%3BIppolito%2C+A%3BIllei%2C+G+G&rft.aulast=Hasni&rft.aufirst=S&rft.date=2011-10-01&rft.volume=17&rft.issue=7&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Oral+Diseases&rft.issn=1354523X&rft_id=info:doi/10.1111%2Fj.1601-0825.2011.01796.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Document feature - figure 0 N1 - Last updated - 2014-03-20 N1 - SubjectsTermNotLitGenreText - Autoimmune diseases; Helicobacter pylori DO - http://dx.doi.org/10.1111/j.1601-0825.2011.01796.x ER - TY - JOUR T1 - Unpacking the Blockers: Understanding Perceptions and Social Constraints of Health Communication in Hereditary Breast Ovarian Cancer (HBOC) Susceptibility Families AN - 1018378131; 201211580 AB - Family communication is essential for accurate cancer risk assessment and counseling; family blockers play a role in this communication process. This qualitative analysis of social exchanges is an extension of earlier work characterizing those who are perceived by study participants as health information gatherers, disseminators, and blockers within families with Hereditary Breast and Ovarian Cancer (HBOC) susceptibility. Eighty-nine women, ages 23-56 years, enrolled in a Breast Imaging Study (BIS) and participated in a sub-study utilizing a social assessment tool known as the Colored Ecological Genetic Relational Map (CEGRM). Purposive sampling ensured that participants varied according to numbers of participating family members e.g., ranging from 1 to 6. Eighty-nine women from 42 families (1-8 relatives/family) participated. They collectively designated 65 blockers, both male and female. Situational factors, beliefs, attitudes and cultural traditions, privacy and protectiveness comprised perceived reasons for blocking intra-family health communications. Longitudinal data collected over 4 years showed families where blocking behavior was universally recognized and stable over time, as well as other families where blocking was less consistent. Self-blocking was observed among a significant minority of participating women. Blocking of health communications among family members with HBOC was variable, complex, and multifaceted. The reasons for blocking were heterogeneous; duration of the blocking appeared to depend on the reasons for blocking. Blocking often seemed to involve bi-directional feedback loops, in keeping with Lepore's Social Constraints and Modulation Theory. Privacy and protectiveness predominated as explanations for long-term blocking. Adapted from the source document. JF - Journal of Genetic Counseling AU - Peters, June A AU - Kenen, Regina AU - Hoskins, Lindsey M AU - Koehly, Laura M AU - Graubard, Barry AU - Loud, Jennifer T AU - Greene, Mark H AD - Clinical Genetics Branch (CGB), Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), 6120 Executive Blvd, Rockville, MD, 20852, USA petersju@mail.nih.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 450 EP - 464 PB - Springer Science+Business Media, New York NY VL - 20 IS - 5 SN - 1059-7700, 1059-7700 KW - Ovarian cancer KW - Blocking KW - Women KW - Health KW - Relatives KW - Susceptibility KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018378131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Genetic+Counseling&rft.atitle=Unpacking+the+Blockers%3A+Understanding+Perceptions+and+Social+Constraints+of+Health+Communication+in+Hereditary+Breast+Ovarian+Cancer+%28HBOC%29+Susceptibility+Families&rft.au=Peters%2C+June+A%3BKenen%2C+Regina%3BHoskins%2C+Lindsey+M%3BKoehly%2C+Laura+M%3BGraubard%2C+Barry%3BLoud%2C+Jennifer+T%3BGreene%2C+Mark+H&rft.aulast=Peters&rft.aufirst=June&rft.date=2011-10-01&rft.volume=20&rft.issue=5&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=Journal+of+Genetic+Counseling&rft.issn=10597700&rft_id=info:doi/10.1007%2Fs10897-011-9370-0 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JGCOET N1 - SubjectsTermNotLitGenreText - Blocking; Relatives; Women; Ovarian cancer; Health; Susceptibility DO - http://dx.doi.org/10.1007/s10897-011-9370-0 ER - TY - JOUR T1 - Seeing Standards: A Visualization of the Metadata Universe AN - 1018335007; 201205911 AB - Seeing Standards (http://www.dlib.indiana.edu/~jenlrile/metadatamap/) is a visualization of metadata standards developed by Jenn Riley, Metadata Librarian at the Indiana University Digital Library Program. It is intended to "assist planners with the selection and implementation of metadata standards" through a visualization of an astounding 105 standards from AACR2 to the Art and Architecture Thesaurus, from Dublin Core to DTD, MODS, ONIX, SKOS, VRA Core, Z39.50 and an number in between. Adapted from the source document. JF - Technical Services Quarterly AU - Landesman, Betty AD - National Institutes of Health Library, Bethesda, MD Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 459 EP - 460 PB - Taylor & Francis, Philadelphia PA VL - 28 IS - 4 SN - 0731-7131, 0731-7131 KW - Web sites KW - Visualization KW - Standards KW - Metadata KW - article KW - 12.11: CATALOGUING AND INDEXING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018335007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Services+Quarterly&rft.atitle=Seeing+Standards%3A+A+Visualization+of+the+Metadata+Universe&rft.au=Landesman%2C+Betty&rft.aulast=Landesman&rft.aufirst=Betty&rft.date=2011-10-01&rft.volume=28&rft.issue=4&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Technical+Services+Quarterly&rft.issn=07317131&rft_id=info:doi/10.1080%2F07317131.2011.598072 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Standards; Visualization; Metadata; Web sites DO - http://dx.doi.org/10.1080/07317131.2011.598072 ER - TY - JOUR T1 - Identification and removal of proteins that co-purify with infectious prion protein improves the analysis of its secondary structure AN - 1017979477; 16717026 AB - Prion diseases are neurodegenerative disorders associated with the accumulation of an abnormal isoform of the mammalian prion protein (PrP). Fourier transform infrared spectroscopy (FTIR) has previously been used to show that the conformation of aggregated, infectious PrP (PrPSc) varies between prion strains and these unique conformations may determine strain-specific disease phenotypes. However, the relative amounts of -helix, Delta *b-sheet and other secondary structures have not always been consistent between studies, suggesting that other proteins might be confounding the analysis of PrPSc secondary structure. We have used FTIR and LC-MS/MS to analyze enriched PrPSc from mouse and hamster prion strains both before and after the removal of protein contaminants that commonly co-purify with PrPSc. Our data show that non-PrP proteins do contribute to absorbances that have been associated with -helical, loop, turn and Delta *b-sheet structures attributed to PrPSc. The major contaminant, the -helical protein ferritin, absorbs strongly at 1652cm-1 in the FTIR spectrum associated with PrPSc. However, even the removal of more than 99% of the ferritin from PrPSc did not completely abolish absorbance at 1652cm-1. Our results show that contaminating proteins alter the FTIR spectrum attributed to PrPSc and suggest that the -helical, loop/turn and Delta *b-sheet secondary structure that remains following their removal are derived from PrPSc itself. JF - Proteomics AU - Moore, Roger A AU - Timmes, Andrew G AU - Wilmarth, Phillip A AU - Safronetz, David AU - Priola, Suzette A AD - Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Laboratory of Persistent Viral Diseases, National Institutes of Health, Hamilton, MT, USA, rmoore@niaid.nih.gov Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 3853 EP - 3865 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 11 IS - 19 SN - 1615-9861, 1615-9861 KW - CSA Neurosciences Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Protein structure KW - Neurodegenerative diseases KW - Data processing KW - I.R. spectroscopy KW - Secondary structure KW - Prion protein KW - Ferritin KW - proteomics KW - Absorbance KW - Contaminants KW - N3 11007:Neurobiology KW - W 30960:Bioinformatics & Computer Applications KW - V 22380:Prions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017979477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics&rft.atitle=Identification+and+removal+of+proteins+that+co-purify+with+infectious+prion+protein+improves+the+analysis+of+its+secondary+structure&rft.au=Moore%2C+Roger+A%3BTimmes%2C+Andrew+G%3BWilmarth%2C+Phillip+A%3BSafronetz%2C+David%3BPriola%2C+Suzette+A&rft.aulast=Moore&rft.aufirst=Roger&rft.date=2011-10-01&rft.volume=11&rft.issue=19&rft.spage=3853&rft.isbn=&rft.btitle=&rft.title=Proteomics&rft.issn=16159861&rft_id=info:doi/10.1002%2Fpmic.201100253 L2 - http://onlinelibrary.wiley.com/doi/10.1002/pmic.201100253/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Protein structure; Neurodegenerative diseases; Data processing; I.R. spectroscopy; Secondary structure; Prion protein; Ferritin; Absorbance; proteomics; Contaminants DO - http://dx.doi.org/10.1002/pmic.201100253 ER - TY - JOUR T1 - Language Use and Adherence to Multiple Cancer Preventive Health Behaviors Among Hispanics AN - 1010709034; 201209186 AB - Hispanics have lower cancer mortality rates than non-Hispanic Whites and Blacks, despite demographic profiles previously associated with higher cancer mortality. Differences in adherence to multiple cancer-preventive behaviors by acculturation may offer one explanation for this "Hispanic paradox," but the relationship is not well understood. We examined this relationship using the 2000 National Health Interview Survey, which provides cross-sectional data on a nationally representative sample of US Hispanics. Multinomial logistic regression models estimated relationships between language use (a measure of acculturation) and patterns of adherence, by gender, to multiple cancer-preventive health behaviors using adherence scores. Hispanics had greater odds of adherence to multiple behaviors compared to Non-Hispanics (OR = 2.76 [2.27, 3.36]). Hispanics with greater English language use had lower odds of adherence (OR = 0.45 [0.29, 0.69]). Women were more adherent than men (P < 0.01) and their language use was associated with patterns of behavioral adherence more so than among men. Differences by gender and language use were identified in patterns of adherence to behavioral recommendations among the Hispanic population. Greater English language use was negatively associated with tobacco, alcohol, fruit and vegetable recommendation adherence but not with exercise. Study findings support evidence behaviors occur in combination and contributes to understanding of the role of language use in patterns of behavioral adherence. Adapted from the source document. JF - Journal of Immigrant and Minority Health AU - Oh, April AU - Dodd, Kevin AU - Ballard-Barbash, Rachel AU - Perna, Frank M AU - Berrigan, David AD - National Cancer Institute, Division of Cancer Control and Prevention, Behavioral Research Program, Health Promotion Research Branch, 6130 Executive Blvd, Room 4087B, MSC 7335, Rockville, MD, 20852-7335, USA ohay@mail.nih.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 849 EP - 859 PB - Springer, Dordrecht The Netherlands VL - 13 IS - 5 SN - 1557-1912, 1557-1912 KW - Healthy food KW - Acculturation KW - Hispanic people KW - Adherence KW - Gender differences KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010709034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immigrant+and+Minority+Health&rft.atitle=Language+Use+and+Adherence+to+Multiple+Cancer+Preventive+Health+Behaviors+Among+Hispanics&rft.au=Oh%2C+April%3BDodd%2C+Kevin%3BBallard-Barbash%2C+Rachel%3BPerna%2C+Frank+M%3BBerrigan%2C+David&rft.aulast=Oh&rft.aufirst=April&rft.date=2011-10-01&rft.volume=13&rft.issue=5&rft.spage=849&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immigrant+and+Minority+Health&rft.issn=15571912&rft_id=info:doi/10.1007%2Fs10903-011-9456-7 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Adherence; Hispanic people; Cancer; Healthy food; Acculturation; Gender differences DO - http://dx.doi.org/10.1007/s10903-011-9456-7 ER - TY - JOUR T1 - Polymorphic triple beta-sheet structures contribute to amide hydrogen/deuterium (H/D) exchange protection in the Alzheimer amyloid beta42 peptide. AN - 894815383; 21832091 AB - Characterization of the polymorphic structural range of Aβ oligomers is important to the understanding of the mechanisms of toxicity. Yet for highly polymorphic ensembles, experimental structural elucidation is difficult. Here, we use a combination of NMR solvent protection experiments and computational structural screening to identify major species in the amyloid conformational ensemble. We examined the polymorphic pentamer and fibril seeds of Aβ42 and its mutants and compared the theoretical backbone amide protection obtained from simulations with experimental hydrogen/deuterium (H/D) exchange protection ratio. We observed that highly flexible pentamers do not share structural similarities with fibril seed oligomers, except the turn regions. We found that a novel amyloid structural motif of a triple β-sheet, with the N-terminal residues interacting with the core (Lys(17)-Glu(22)) β-sheet region, correlates with H/D exchange protection. The triple β-sheet Aβ42 oligomer has a minimal exposure of hydrophobic residues and is further stabilized by the E22Q (Dutch) mutation in Alzheimer disease. The experimental H/D exchange solvent protection ratio implies that triple β-sheet fibrils and globulomers could coexist in the Aβ42 ensemble, pointing to a broad heterogeneous aggregate population. Our results suggest that an approach that combines computational modeling with NMR protection data can be a useful strategy for obtaining clues to the preferred conformational species of the assemblies in solution and help in alleviating experimental difficulties and consequently possible errors in the exchange data for Aβ42 fibrils. JF - The Journal of biological chemistry AU - Ma, Buyong AU - Nussinov, Ruth AD - SAIC-Frederick, Inc, Center for Cancer Research Nanobiology Program, NCI, National Institutes of Health, Frederick, Maryland 21702, USA. mabuyong@mail.nih.gov Y1 - 2011/09/30/ PY - 2011 DA - 2011 Sep 30 SP - 34244 EP - 34253 VL - 286 IS - 39 KW - Amyloid KW - 0 KW - Amyloid beta-Peptides KW - Peptide Fragments KW - amyloid beta-protein (1-42) KW - Index Medicus KW - Protein Structure, Secondary KW - Alzheimer Disease -- genetics KW - Humans KW - Alzheimer Disease -- metabolism KW - Deuterium Exchange Measurement KW - Peptide Fragments -- metabolism KW - Amyloid beta-Peptides -- genetics KW - Peptide Fragments -- chemistry KW - Peptide Fragments -- genetics KW - Amyloid beta-Peptides -- metabolism KW - Amyloid beta-Peptides -- chemistry KW - Amyloid -- chemistry KW - Models, Chemical KW - Amyloid -- genetics KW - Mutation KW - Amyloid -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/894815383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Polymorphic+triple+beta-sheet+structures+contribute+to+amide+hydrogen%2Fdeuterium+%28H%2FD%29+exchange+protection+in+the+Alzheimer+amyloid+beta42+peptide.&rft.au=Ma%2C+Buyong%3BNussinov%2C+Ruth&rft.aulast=Ma&rft.aufirst=Buyong&rft.date=2011-09-30&rft.volume=286&rft.issue=39&rft.spage=34244&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M111.241141 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-22 N1 - Date created - 2011-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Neurosci. 2001 Jun;13(11):2015-24 [11422442] J Mol Biol. 2011 Jan 21;405(3):851-62 [21108949] Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14126-31 [12391326] Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16742-7 [12481027] Lancet. 2003 Jun 7;361(9373):1957-8 [12801742] J Biol Chem. 2003 Jun 27;278(26):23221-6 [12695513] J Comput Chem. 2003 Aug;24(11):1348-56 [12827676] Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14790-5 [14657385] Biochemistry. 2005 Mar 22;44(11):4434-41 [15766273] J Comput Chem. 2005 Dec;26(16):1781-802 [16222654] Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17342-7 [16293696] Biochemistry. 2006 Jan 17;45(2):498-512 [16401079] J Biol Chem. 2006 Jan 6;281(1):477-83 [16215229] Biochemistry. 2006 May 2;45(17):5503-16 [16634632] Curr Opin Chem Biol. 2006 Oct;10(5):445-52 [16935548] J Biol Chem. 2007 Feb 16;282(7):4916-23 [17170111] Angew Chem Int Ed Engl. 2007;46(8):1246-52 [17203498] Biochem J. 2007 May 15;404(1):63-70 [17280549] Biophys J. 2007 Jun 1;92(11):4064-77 [17307823] Biochim Biophys Acta. 2007 Aug;1768(8):1886-99 [17499210] Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5099-104 [18375754] Neurobiol Dis. 2008 May;30(2):212-20 [18353662] Anal Biochem. 2009 Feb 15;385(2):374-6 [19027706] Angew Chem Int Ed Engl. 2009;48(11):1981-6 [19035593] Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4653-8 [19264960] Proc Natl Acad Sci U S A. 2009 May 5;106(18):7443-8 [19376973] Biochemistry. 2009 Mar 10;48(9):1870-7 [19216516] Biochemistry. 2009 Jul 7;48(26):6072-84 [19358576] Biophys J. 2009 Aug 5;97(3):912-21 [19651050] Nat Struct Mol Biol. 2009 Sep;16(9):973-8 [19684598] Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19813-8 [19843697] Protein Sci. 2010 Feb;19(2):349-56 [19998407] J Biol Chem. 2010 Feb 26;285(9):6071-9 [20018889] Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3487-92 [20133726] Biophys J. 2010 Jan 20;98(2):282-96 [20338850] Nat Struct Mol Biol. 2010 May;17(5):561-7 [20383142] Chemistry. 2010 May 10;16(18):5492-9 [20358555] Chem Rev. 2010 Aug 11;110(8):4820-38 [20402519] Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14128-33 [20660780] Biochemistry. 2010 Oct 19;49(41):8967-77 [20731379] J Biol Chem. 2010 Nov 19;285(47):37102-10 [20847046] J Mol Biol. 2010 Nov 26;404(2):337-52 [20887731] Protein Sci. 2002 Jul;11(7):1639-47 [12070316] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M111.241141 ER - TY - JOUR T1 - Pubertal delay in male nonhuman primates (Macaca mulatta) treated with methylphenidate. AN - 894816366; 21930929 AB - Juvenile male rhesus monkeys treated with methylphenidate hydrochloride (MPH) to evaluate genetic and behavioral toxicity were observed after 14 mo of treatment to have delayed pubertal progression with impaired testicular descent and reduced testicular volume. Further evaluation of animals dosed orally twice a day with (i) 0.5 mL/kg of vehicle (n = 10), (ii) 0.15 mg/kg of MPH increased to 2.5 mg/kg (low dose, n = 10), or (iii) 1.5 mg/kg of MPH increased to 12.5 mg/kg (high dose, n = 10) for a total of 40 mo revealed that testicular volume was significantly reduced (P < 0.05) at months 15 to 19 and month 27. Testicular descent was significantly delayed (P < 0.05) in the high-dose group. Significantly lower serum testosterone levels were detected in both the low- (P = 0.0017) and high-dose (P = 0.0011) animals through month 33 of treatment. Although serum inhibin B levels were increased overall in low-dose animals (P = 0.0328), differences between groups disappeared by the end of the study. Our findings indicate that MPH administration, beginning before puberty, and which produced clinically relevant blood levels of the drug, impaired pubertal testicular development until ∼5 y of age. It was not possible to resolve whether MPH delayed the initiation of the onset of puberty or reduced the early tempo of the developmental process. Regardless, deficits in testicular volume and hormone secretion disappeared over the 40-mo observation period, suggesting that the impact of MPH on puberty is not permanent. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Mattison, Donald R AU - Plant, Tony M AU - Lin, Hui-Min AU - Chen, Hung-Chia AU - Chen, James J AU - Twaddle, Nathan C AU - Doerge, Daniel AU - Slikker, William AU - Patton, Ralph E AU - Hotchkiss, Charlotte E AU - Callicott, Ralph J AU - Schrader, Steven M AU - Turner, Terry W AU - Kesner, James S AU - Vitiello, Benedetto AU - Petibone, Dayton M AU - Morris, Suzanne M AD - Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, The Eunice Kennedy Shriver National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. mattisod@mail.nih.gov Y1 - 2011/09/27/ PY - 2011 DA - 2011 Sep 27 SP - 16301 EP - 16306 VL - 108 IS - 39 KW - Central Nervous System Stimulants KW - 0 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Testosterone KW - 3XMK78S47O KW - Index Medicus KW - Testis -- growth & development KW - Animals KW - Testis -- drug effects KW - Testosterone -- blood KW - Macaca mulatta KW - Male KW - Sexual Maturation -- drug effects KW - Central Nervous System Stimulants -- pharmacology KW - Methylphenidate -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/894816366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Pubertal+delay+in+male+nonhuman+primates+%28Macaca+mulatta%29+treated+with+methylphenidate.&rft.au=Mattison%2C+Donald+R%3BPlant%2C+Tony+M%3BLin%2C+Hui-Min%3BChen%2C+Hung-Chia%3BChen%2C+James+J%3BTwaddle%2C+Nathan+C%3BDoerge%2C+Daniel%3BSlikker%2C+William%3BPatton%2C+Ralph+E%3BHotchkiss%2C+Charlotte+E%3BCallicott%2C+Ralph+J%3BSchrader%2C+Steven+M%3BTurner%2C+Terry+W%3BKesner%2C+James+S%3BVitiello%2C+Benedetto%3BPetibone%2C+Dayton+M%3BMorris%2C+Suzanne+M&rft.aulast=Mattison&rft.aufirst=Donald&rft.date=2011-09-27&rft.volume=108&rft.issue=39&rft.spage=16301&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.1102187108 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-21 N1 - Date created - 2011-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Endocrinol Metab. 2000 Sep;85(9):3239-44 [10999815] J Mol Med (Berl). 2001;79(1):8-20 [11327106] Mol Cell Endocrinol. 2001 Jun 30;180(1-2):93-101 [11451577] Endocrinology. 2003 Apr;144(4):1175-85 [12639898] Biol Reprod. 1981 Sep;25(2):244-52 [6796135] Endocr Rev. 1986 Feb;7(1):75-88 [3082617] Endocrinology. 1998 Jun;139(6):2774-83 [9607784] J Clin Endocrinol Metab. 1998 Jun;83(6):1835-41 [9626105] J Androl. 1999 May-Jun;20(3):430-4 [10386823] Ann N Y Acad Sci. 2005 Dec;1061:149-62 [16467264] Brain Res Bull. 2006 Oct 16;70(4-6):422-9 [17027778] Ann N Y Acad Sci. 2006 Aug;1074:52-73 [17105903] Child Dev. 2007 May-Jun;78(3):927-37 [17517013] J Am Acad Child Adolesc Psychiatry. 2007 Aug;46(8):1015-27 [17667480] Biol Reprod. 2008 Jul;79(1):93-9 [18367678] Mutat Res. 2009 Feb 19;673(1):59-66 [19135169] Ann Intern Med. 2010 Jan 19;152(2):93-100 [20083828] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.1102187108 ER - TY - JOUR T1 - Meat-cooking mutagens and risk of renal cell carcinoma AN - 1008840399; 16451020 AB - Background: High-temperature cooked meat contains two families of carcinogens, heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs). Given the kidneys' role in metabolism and urinary excretion of these compounds, we investigated meat-derived mutagens, as well as meat intake and cooking methods, in a population-based case-control study conducted in metropolitan Detroit and Chicago. Methods: Newly diagnosed, histologically confirmed adenocarcinoma of the renal parenchyma (renal cell carcinoma (RCC)) cases (n=1192) were frequency matched on age, sex, and race to controls (n=1175). The interviewer-administered Diet History Questionnaire (DHQ) included queries for meat-cooking methods and doneness with photographic aids. Levels of meat mutagens were estimated using the DHQ in conjunction with the CHARRED database. Results: The risk of RCC increased with intake of barbecued meat (P sub(trend)=0.04) and the PAH, benzo(a)pyrene (BaP) (multivariable-adjusted odds ratio and 95% confidence interval, highest vs lowest quartile: 1.50 (1.14, 1.95), P sub(trend)=0.001). With increasing BaP intake, the risk of RCC was more than twofold in African Americans and current smokers (P sub(interaction)<0.05). We found no association for HCAs or overall meat intake. Conclusion: BaP intake, a PAH in barbecued meat, was positively associated with RCC. These biologically plausible findings advocate further epidemiological investigation into dietary intake of BaP and risk of RCC. JF - British Journal of Cancer AU - Daniel, C R AU - Schwartz, K L AU - Colt, J S AU - Dong, L M AU - Ruterbusch, J J AU - Purdue, M P AU - Cross, A J AU - Rothman, N AU - Davis, F G AU - Wacholder, S AU - Graubard, B I AU - Chow, W H AU - Sinha, R AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Rockville, MD 20852, USA Y1 - 2011/09/27/ PY - 2011 DA - 2011 Sep 27 SP - 1096 EP - 1104 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 105 IS - 7 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - USA, Illinois, Chicago KW - Diets KW - Mutagens KW - USA, Michigan, Detroit KW - Urine KW - meat KW - Kidney KW - cooking KW - Excretion KW - Cancer KW - Metabolism KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1008840399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Meat-cooking+mutagens+and+risk+of+renal+cell+carcinoma&rft.au=Daniel%2C+C+R%3BSchwartz%2C+K+L%3BColt%2C+J+S%3BDong%2C+L+M%3BRuterbusch%2C+J+J%3BPurdue%2C+M+P%3BCross%2C+A+J%3BRothman%2C+N%3BDavis%2C+F+G%3BWacholder%2C+S%3BGraubard%2C+B+I%3BChow%2C+W+H%3BSinha%2C+R&rft.aulast=Daniel&rft.aufirst=C&rft.date=2011-09-27&rft.volume=105&rft.issue=7&rft.spage=1096&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fbjc.2011.343 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Diets; Mutagens; Urine; meat; Kidney; Excretion; cooking; Metabolism; Cancer; USA, Illinois, Chicago; USA, Michigan, Detroit DO - http://dx.doi.org/10.1038/bjc.2011.343 ER - TY - CPAPER T1 - Regulation of Innate Host Factors by Mycobacterium avium Perpetuates Survival in Human Macrophages T2 - 2011 Annual Meeting of The Society for Leukocyte Biology (SLB 2011) AN - 1313024915; 6061152 JF - 2011 Annual Meeting of The Society for Leukocyte Biology (SLB 2011) AU - Vazquez, Nancy Y1 - 2011/09/22/ PY - 2011 DA - 2011 Sep 22 KW - survival KW - Macrophages KW - Cell survival KW - Mycobacterium avium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313024915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+The+Society+for+Leukocyte+Biology+%28SLB+2011%29&rft.atitle=Regulation+of+Innate+Host+Factors+by+Mycobacterium+avium+Perpetuates+Survival+in+Human+Macrophages&rft.au=Vazquez%2C+Nancy&rft.aulast=Vazquez&rft.aufirst=Nancy&rft.date=2011-09-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+The+Society+for+Leukocyte+Biology+%28SLB+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://leukocytebiology.org/PDFS/25/258e8f80-a8cd-4763-a3fd-b2dfdb866b2a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Structural Insights into the Activation and Inhibition of Histo-Aspartic Protease from Plasmodium falciparum AN - 926895568; 16063853 AB - Histo-aspartic protease (HAP) from Plasmodium falciparum is a promising target for the development of novel antimalarial drugs. The sequence of HAP is highly similar to those of pepsin-like aspartic proteases, but one of the two catalytic aspartates, Asp32, is replaced with histidine. Crystal structures of the truncated zymogen of HAP and of the complex of the mature enzyme with inhibitor KNI-10395 have been determined at 2.1 and 2.5 A resolution, respectively. As in other proplasmepsins, the propeptide of the zymogen interacts with the C-terminal domain of the enzyme, forcing the N- and C-terminal domains apart, thereby separating His32 and Asp215 and preventing formation of the mature active site. In the inhibitor complex, the enzyme forms a tight domain-swapped dimer, not previously seen in any aspartic proteases. The inhibitor is found in an unprecedented conformation resembling the letter U, stabilized by two intramolecular hydrogen bonds. Surprisingly, the location and conformation of the inhibitor are similar to those of the fragment of helix 2 comprising residues 34p--38p in the prosegments of the zymogens of gastric aspartic proteases; a corresponding helix assumes a vastly different orientation in proplasmepsins. Each inhibitor molecule is in contact with two molecules of HAP, interacting with the carboxylate group of the catalytic Asp215 of one HAP protomer through a water molecule, while also making a direct hydrogen bond to Glu278A' of the other protomer. A comparison of the shifts in the positions of the catalytic residues in the inhibitor complex presented here with those published previously gives further hints regarding the enzymatic mechanism of HAP. JF - Biochemistry (Washington) AU - Bhaumik, Prasenjit AU - Xiao, Huogen AU - Hidaka?, Koushi AU - Gustchina, Alla AU - Kiso?, Yoshiaki AU - Yada, Rickey Y AU - Wlodawer, Alexander AD - Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland 21702, United States Y1 - 2011/09/19/ PY - 2011 DA - 2011 Sep 19 SP - 8862 EP - 8879 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 United States VL - 50 IS - 41 SN - 0006-2960, 0006-2960 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Enzymes KW - Drug development KW - Plasmodium falciparum KW - Proenzymes KW - USA, Washington KW - aspartic endopeptidase KW - Hydrogen bonding KW - Histidine KW - Crystal structure KW - Inhibitors KW - Drugs KW - Conformation KW - K 03340:Effects of Physical & Chemical Factors KW - Q1 08625:Non-edible products KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926895568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Structural+Insights+into+the+Activation+and+Inhibition+of+Histo-Aspartic+Protease+from+Plasmodium+falciparum&rft.au=Bhaumik%2C+Prasenjit%3BXiao%2C+Huogen%3BHidaka%3F%2C+Koushi%3BGustchina%2C+Alla%3BKiso%3F%2C+Yoshiaki%3BYada%2C+Rickey+Y%3BWlodawer%2C+Alexander&rft.aulast=Bhaumik&rft.aufirst=Prasenjit&rft.date=2011-09-19&rft.volume=50&rft.issue=41&rft.spage=8862&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi201118z L2 - http://pubs.acs.org/doi/abs/10.1021/bi201118z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Parasites; Inhibitors; Drugs; aspartic endopeptidase; Hydrogen bonding; Histidine; Crystal structure; Enzymes; Drug development; Proenzymes; Conformation; Plasmodium falciparum; USA, Washington DO - http://dx.doi.org/10.1021/bi201118z ER - TY - CPAPER T1 - Bacterial Infections in Immunodeficiency: Still Emerging After All These Years T2 - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AN - 1313095525; 6110678 JF - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AU - Holland, Steven Y1 - 2011/09/17/ PY - 2011 DA - 2011 Sep 17 KW - Infection KW - Immunodeficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313095525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.atitle=Bacterial+Infections+in+Immunodeficiency%3A+Still+Emerging+After+All+These+Years&rft.au=Holland%2C+Steven&rft.aulast=Holland&rft.aufirst=Steven&rft.date=2011-09-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icaac.org/images/icaac2011_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Nontuberculous Mycobacteria: An Emerging Pathogen in CF T2 - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AN - 1313021961; 6111518 JF - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AU - Olivier, Kenneth Y1 - 2011/09/17/ PY - 2011 DA - 2011 Sep 17 KW - Pathogens UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313021961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.atitle=Nontuberculous+Mycobacteria%3A+An+Emerging+Pathogen+in+CF&rft.au=Olivier%2C+Kenneth&rft.aulast=Olivier&rft.aufirst=Kenneth&rft.date=2011-09-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icaac.org/images/icaac2011_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Regulation by Small RNAs in Bacteria: Expanding Frontiers AN - 1762380649; 15744580 JF - Molecular Cell AU - Storz, Gisela AU - Vogel, Joerg AU - Wassarman, Karen M Y1 - 2011/09/16/ PY - 2011 DA - 2011 Sep 16 SP - 880 EP - 891 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 United States VL - 43 IS - 6 SN - 1097-2765, 1097-2765 KW - Microbiology Abstracts B: Bacteriology KW - Bacteria KW - J 02490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762380649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cell&rft.atitle=Regulation+by+Small+RNAs+in+Bacteria%3A+Expanding+Frontiers&rft.au=Storz%2C+Gisela%3BVogel%2C+Joerg%3BWassarman%2C+Karen+M&rft.aulast=Storz&rft.aufirst=Gisela&rft.date=2011-09-16&rft.volume=43&rft.issue=6&rft.spage=880&rft.isbn=&rft.btitle=&rft.title=Molecular+Cell&rft.issn=10972765&rft_id=info:doi/10.1016%2Fj.molcel.2011.08.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Bacteria DO - http://dx.doi.org/10.1016/j.molcel.2011.08.022 ER - TY - JOUR T1 - CAM-CM: a signal deconvolution tool for in vivo dynamic contrast-enhanced imaging of complex tissues AN - 915484152; 16101662 AB - Summary: In vivo dynamic contrast-enhanced imaging tools provide non-invasive methods for analyzing various functional changes associated with disease initiation, progression and responses to therapy. The quantitative application of these tools has been hindered by its inability to accurately resolve and characterize targeted tissues due to spatially mixed tissue heterogeneity. Convex Analysis of Mixtures - Compartment Modeling (CAM-CM) signal deconvolution tool has been developed to automatically identify pure-volume pixels located at the corners of the clustered pixel time series scatter simplex and subsequently estimate tissue-specific pharmacokinetic parameters. CAM-CM can dissect complex tissues into regions with differential tracer kinetics at pixel-wise resolution and provide a systems biology tool for defining imaging signatures predictive of phenotypes. JF - Bioinformatics AU - Chen, Li AU - Chan, Tsung-Han AU - Choyke, Peter L AU - Hillman, Elizabeth MC AU - Chi, Chong-Yung AU - Bhujwalla, Zaver M AU - Wang, Ge AU - Wang, Sean S AU - Szabo, Zsolt AU - Wang, Yue AD - super(1)Bradley Department of Electrical and Computer Engineering, Virginia Tech, Arlington, VA 22203, USA, super(2)Department of Electrical Engineering, National Tsing Hua University, Taiwan, ROC 30013, super(3)Molecular Imaging Program, National Cancer Institute, NIH, Bethesda, MD 20892, super(4)Department of Biomedical Engineering and Radiology, Columbia University, New York, NY 10027, super(5)Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, super(6)School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24061 and super(7)Science, Mathematics, Computer Science House, Poolesville High School, Poolesville, MD 20837, USA, Y1 - 2011/09/15/ PY - 2011 DA - 2011 Sep 15 SP - 2607 EP - 2609 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 27 IS - 18 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Tracers KW - Data processing KW - Kinetics KW - Bioinformatics KW - imaging KW - Internet KW - Pharmacokinetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/915484152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=CAM-CM%3A+a+signal+deconvolution+tool+for+in+vivo+dynamic+contrast-enhanced+imaging+of+complex+tissues&rft.au=Chen%2C+Li%3BChan%2C+Tsung-Han%3BChoyke%2C+Peter+L%3BHillman%2C+Elizabeth+MC%3BChi%2C+Chong-Yung%3BBhujwalla%2C+Zaver+M%3BWang%2C+Ge%3BWang%2C+Sean+S%3BSzabo%2C+Zsolt%3BWang%2C+Yue&rft.aulast=Chen&rft.aufirst=Li&rft.date=2011-09-15&rft.volume=27&rft.issue=18&rft.spage=2607&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtr436 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Tracers; Data processing; Kinetics; Bioinformatics; imaging; Pharmacokinetics; Internet DO - http://dx.doi.org/10.1093/bioinformatics/btr436 ER - TY - JOUR T1 - Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1[alpha] inhibitors AN - 907167479; 15700287 AB - Quinazolin-4-one 1 was identified as an inhibitor of the HIF-1[alpha] transcriptional factor from a high-throughput screen. HIF-1[alpha] up-regulation is common in many cancer cells. In this Letter, we describe an efficient one-pot sequential reaction for the synthesis of quinazolin-4-one 1 analogues. The structure-activity relationship (SAR) study led to the 5-fold more potent analogue, 16. JF - Bioorganic and Medicinal Chemistry Letters AU - Huang, Wenwei AU - Huang, Ruili AU - Attene-Ramos, Matias S AU - Sakamuru, Srilatha AU - Englund, Erika E AU - Inglese, James AU - Austin, Christopher P AU - Xia, Menghang Y1 - 2011/09/15/ PY - 2011 DA - 2011 Sep 15 SP - 5239 EP - 5243 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 21 IS - 18 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - Structure-activity relationships KW - Cancer KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907167479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Synthesis+and+evaluation+of+quinazolin-4-ones+as+hypoxia-inducible+factor-1%5Balpha%5D+inhibitors&rft.au=Huang%2C+Wenwei%3BHuang%2C+Ruili%3BAttene-Ramos%2C+Matias+S%3BSakamuru%2C+Srilatha%3BEnglund%2C+Erika+E%3BInglese%2C+James%3BAustin%2C+Christopher+P%3BXia%2C+Menghang&rft.aulast=Huang&rft.aufirst=Wenwei&rft.date=2011-09-15&rft.volume=21&rft.issue=18&rft.spage=5239&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2011.07.043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Structure-activity relationships; Cancer DO - http://dx.doi.org/10.1016/j.bmcl.2011.07.043 ER - TY - JOUR T1 - Automated volumetric growth plate measurement using magnetic resonance imaging for monitoring skeletal toxicity in children treated on investigational drug trials. AN - 892945229; 21807634 AB - Targeted anticancer agents have been reported to have side effects on the skeletal system such as thickening of the epiphyseal growth plate in preclinical models of juvenile, but not mature, animals. Careful evaluation of skeletal toxicity in the clinical development of targeted therapies for children is required. We validated a novel method to measure the growth plate volume using MRI. A semiautomated method of volumetric growth plate measurement was developed on the basis of the differences of pixel intensity of the growth plate from surrounding bone on T(1) sagittal MRI. Two observers measured the femoral growth plate volume and thickness on three different days using 20 pediatric knee MRIs obtained at the NIH. Five subjects had two knee MRIs obtained on the same day to evaluate intrasubject reproducibility. Volumetric analysis showed low intraobserver variability, with the coefficient of variation for the two observers ranging from 0.2% to 6.1%. Interobserver correlation was 0.99, and good concordance was shown with a mean volume difference of -1.8 mm(3). One-dimensional measurements had poorer intra and interobserver consistency. No statistically significant differences in volumetric measurements were observed between the two scans done on the same day in five subjects (P = 0.5). MRI volumetric growth plate measurement is a reproducible and sensitive method to evaluate meaningful growth plate volume changes over time. This tool, along with close monitoring of height and laboratory evaluations for bone metabolism, may be used to evaluate potential bone and growth toxicities of children enrolled in trials of investigational drugs. ©2011 AACR. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Kim, AeRang AU - Dombi, Eva AU - Solomon, Jeffrey AU - Fox, Elizabeth AU - Balis, Frank M AU - Widemann, Brigitte C AD - Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA. aekim@cnmc.org Y1 - 2011/09/15/ PY - 2011 DA - 2011 Sep 15 SP - 5982 EP - 5990 VL - 17 IS - 18 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Drugs, Investigational KW - Index Medicus KW - Sensitivity and Specificity KW - Reproducibility of Results KW - Humans KW - Child KW - Observer Variation KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Magnetic Resonance Imaging KW - Drug Monitoring KW - Antineoplastic Agents -- toxicity KW - Drugs, Investigational -- toxicity KW - Growth Plate -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/892945229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Automated+volumetric+growth+plate+measurement+using+magnetic+resonance+imaging+for+monitoring+skeletal+toxicity+in+children+treated+on+investigational+drug+trials.&rft.au=Kim%2C+AeRang%3BDombi%2C+Eva%3BSolomon%2C+Jeffrey%3BFox%2C+Elizabeth%3BBalis%2C+Frank+M%3BWidemann%2C+Brigitte+C&rft.aulast=Kim&rft.aufirst=AeRang&rft.date=2011-09-15&rft.volume=17&rft.issue=18&rft.spage=5982&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-10-2259 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-17 N1 - Date created - 2011-09-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurology. 2009 Oct 20;73(16):1273-9 [19841379] Clin Pharmacol Ther. 2009 Feb;85(2):127-9 [19151636] Blood. 2010 Jan 28;115(4):766-74 [19890095] J Bone Miner Res. 2010 Aug;25(8):1759-70 [20225261] J Clin Oncol. 2010 Nov 1;28(31):4762-8 [20921456] J Clin Oncol. 2010 Dec 10;28(35):5174-81 [21060028] Bone. 2000 Oct;27(4):495-501 [11033444] Trends Cardiovasc Med. 2000 Jul;10(5):223-8 [11282299] J Am Acad Dermatol. 2001 Nov;45(5):S176-82 [11606950] Comput Med Imaging Graph. 2004 Jul;28(5):257-65 [15249071] Cell Biol Int Rep. 1992 Feb;16(2):133-44 [1551145] Nat Med. 1999 Jun;5(6):623-8 [10371499] Cancer Res. 2005 May 15;65(10):4389-400 [15899831] Toxicol Pathol. 2006;34(2):131-47 [16537292] Comp Med. 2006 Dec;56(6):502-11 [17219781] J Clin Oncol. 2008 Jan 20;26(3):399-405 [18202416] Cancer Cell. 2008 Mar;13(3):249-60 [18328428] Oncologist. 2008 Jun;13(6):679-89 [18586923] Pediatr Blood Cancer. 2008 Sep;51(3):418-20 [18493993] Pediatr Blood Cancer. 2009 Feb;52(2):304-5; author reply 306 [18819126] Leukemia. 2009 Nov;23(11):2155-9 [19626049] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-10-2259 ER - TY - JOUR T1 - Separation of mutational and transcriptional enhancers in Ig genes. AN - 888337239; 21844395 AB - Secondary Ig gene diversification relies on activation-induced cytidine deaminase (AID) to create U:G mismatches that are subsequently fixed by mutagenic repair pathways. AID activity is focused to Ig loci by cis-regulatory DNA sequences named targeting elements. In this study, we show that in contrast to prevailing thought in the field, the targeting elements in the chicken IGL locus are distinct from classical transcriptional enhancers. These mutational enhancer elements (MEEs) are required over and above transcription to recruit AID-mediated mutagenesis to Ig loci. We identified a small 222-bp fragment in the chicken IGL locus that enhances mutagenesis without boosting transcription, and this sequence represents a key component of an MEE. Lastly, MEEs are evolutionarily conserved among birds, both in sequence and function, and contain several highly conserved sequence modules that are likely involved in recruiting trans-acting targeting factors. We propose that MEEs represent a novel class of cis-regulatory elements for which the function is to control genomic integrity. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Kothapalli, Naga Rama AU - Collura, Kaitlin M AU - Norton, Darrell D AU - Fugmann, Sebastian D AD - Molecular Immunology Unit, Laboratory of Molecular Biology and Immunology, National Institute on Aging/National Institutes of Health, Biomedical Research Center, Baltimore, MD 21224, USA. Y1 - 2011/09/15/ PY - 2011 DA - 2011 Sep 15 SP - 3247 EP - 3255 VL - 187 IS - 6 KW - Immunoglobulin Light Chains KW - 0 KW - AICDA (activation-induced cytidine deaminase) KW - EC 3.5.4.- KW - Cytidine Deaminase KW - EC 3.5.4.5 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Chickens KW - Base Sequence KW - Blotting, Northern KW - Conserved Sequence KW - Cells, Cultured KW - Blotting, Southern KW - Cytidine Deaminase -- immunology KW - Molecular Sequence Data KW - Cytidine Deaminase -- genetics KW - Mutation KW - DNA Mismatch Repair -- genetics KW - Genes, Immunoglobulin -- genetics KW - Enhancer Elements, Genetic -- genetics KW - Immunoglobulin Light Chains -- genetics KW - DNA Mismatch Repair -- immunology KW - Enhancer Elements, Genetic -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888337239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Separation+of+mutational+and+transcriptional+enhancers+in+Ig+genes.&rft.au=Kothapalli%2C+Naga+Rama%3BCollura%2C+Kaitlin+M%3BNorton%2C+Darrell+D%3BFugmann%2C+Sebastian+D&rft.aulast=Kothapalli&rft.aufirst=Naga&rft.date=2011-09-15&rft.volume=187&rft.issue=6&rft.spage=3247&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/10.4049%2Fjimmunol.1101568 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-09 N1 - Date created - 2011-09-08 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - HQ414233; GENBANK; JF693631 N1 - SuppNotes - Cited By: Genome Res. 2000 Apr;10(4):577-86 [10779500] Cell. 2010 Oct 1;143(1):122-33 [20887897] Cell. 2000 Sep 1;102(5):565-75 [11007475] Science. 2002 Feb 15;295(5558):1301-6 [11847344] Immunity. 2003 Aug;19(2):235-42 [12932357] BMC Biotechnol. 2001;1:7 [11591226] Proc Natl Acad Sci U S A. 2004 May 11;101(19):7352-6 [15123833] Nucleic Acids Res. 1995 Jun 11;23(11):1997-2005 [7596829] Science. 1998 Jun 12;280(5370):1750-2 [9624052] Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11816-21 [9751748] Genome Res. 2005 Jan;15(1):184-94 [15590941] Curr Opin Immunol. 2006 Apr;18(2):164-74 [16464563] Nat Rev Immunol. 2006 Aug;6(8):573-83 [16868548] Adv Immunol. 2007;94:109-25 [17560273] Annu Rev Biochem. 2007;76:1-22 [17328676] Nat Genet. 2008 Jan;40(1):108-12 [18066064] J Immunol. 2008 Feb 15;180(4):2019-23 [18250404] Nature. 2008 Feb 14;451(7180):841-5 [18273020] Mol Immunol. 2008 Apr;45(7):2062-8 [18023479] Mol Biol Evol. 2008 Jun;25(6):1148-57 [18343891] Cell. 2008 Dec 12;135(6):1028-38 [19070574] J Immunol. 2009 Jan 1;182(1):408-15 [19109172] PLoS Genet. 2009 Jan;5(1):e1000332 [19132090] Mol Immunol. 2009 Oct;46(16):3283-91 [19699530] J Exp Med. 2009 Nov 23;206(12):2613-23 [19887393] Nat Cell Biol. 2010 Feb;12(2):111-8 [20098417] J Exp Med. 2010 Feb 15;207(2):405-15 [20100870] Nat Immunol. 2010 Sep;11(9):820-6 [20657597] Cell. 2000 Sep 1;102(5):553-63 [11007474] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4049/jimmunol.1101568 ER - TY - JOUR T1 - Arsenic transformation predisposes human skin keratinocytes to UV-induced DNA damage yet enhances their survival apparently by diminishing oxidant response. AN - 885908939; 21820459 AB - Inorganic arsenic and UV, both human skin carcinogens, may act together as skin co-carcinogens. We find human skin keratinocytes (HaCaT cells) are malignantly transformed by low-level arsenite (100nM, 30weeks; termed As-TM cells) and with transformation concurrently undergo full adaptation to arsenic toxicity involving reduced apoptosis and oxidative stress response to high arsenite concentrations. Oxidative DNA damage (ODD) is a possible mechanism in arsenic carcinogenesis and a hallmark of UV-induced skin cancer. In the current work, inorganic arsenite exposure (100nM) did not induce ODD during the 30weeks required for malignant transformation. Although acute UV-treatment (UVA, 25J/cm(2)) increased ODD in passage-matched control cells, once transformed by arsenic to As-TM cells, acute UV actually further increased ODD (>50%). Despite enhanced ODD, As-TM cells were resistant to UV-induced apoptosis. The response of apoptotic factors and oxidative stress genes was strongly mitigated in As-TM cells after UV exposure including increased Bcl2/Bax ratio and reduced Caspase-3, Nrf2, and Keap1 expression. Several Nrf2-related genes (HO-1, GCLs, SOD) showed diminished responses in As-TM cells after UV exposure consistent with reduced oxidant stress response. UV-exposed As-TM cells showed increased expression of cyclin D1 (proliferation gene) and decreased p16 (tumor suppressor). UV exposure enhanced the malignant phenotype of As-TM cells. Thus, the co-carcinogenicity between UV and arsenic in skin cancer might involve adaptation to chronic arsenic exposure generally mitigating the oxidative stress response, allowing apoptotic by-pass after UV and enhanced cell survival even in the face of increased UV-induced oxidative stress and increased ODD. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Sun, Yang AU - Kojima, Chikara AU - Chignell, Colin AU - Mason, Ronald AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, and National Toxicology Laboratories, National Toxicology Program, the National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2011/09/15/ PY - 2011 DA - 2011 Sep 15 SP - 242 EP - 250 VL - 255 IS - 3 KW - Arsenites KW - 0 KW - Oxidants KW - arsenite KW - N5509X556J KW - Index Medicus KW - Skin -- metabolism KW - Apoptosis -- physiology KW - Humans KW - Apoptosis -- radiation effects KW - Oxidative Stress -- radiation effects KW - Oxidative Stress -- physiology KW - Skin -- radiation effects KW - Skin -- drug effects KW - Cell Survival -- drug effects KW - Apoptosis -- drug effects KW - Ultraviolet Rays -- adverse effects KW - Oxidative Stress -- drug effects KW - Cell Survival -- radiation effects KW - Cell Line KW - Cell Survival -- physiology KW - Keratinocytes -- radiation effects KW - DNA Damage -- physiology KW - Arsenites -- pharmacology KW - Oxidants -- antagonists & inhibitors KW - Keratinocytes -- drug effects KW - Arsenites -- toxicity KW - Oxidants -- metabolism KW - Keratinocytes -- metabolism KW - DNA Damage -- radiation effects KW - DNA Damage -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885908939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Arsenic+transformation+predisposes+human+skin+keratinocytes+to+UV-induced+DNA+damage+yet+enhances+their+survival+apparently+by+diminishing+oxidant+response.&rft.au=Sun%2C+Yang%3BKojima%2C+Chikara%3BChignell%2C+Colin%3BMason%2C+Ronald%3BWaalkes%2C+Michael+P&rft.aulast=Sun&rft.aufirst=Yang&rft.date=2011-09-15&rft.volume=255&rft.issue=3&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2011.07.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-27 N1 - Date created - 2011-08-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Photochem Photobiol. 1999 Oct;70(4):380-90 [10546543] J Natl Cancer Inst. 2010 May 5;102(9):638-49 [20339138] Eur J Cancer. 1999 Dec;35(14):2003-9 [10711242] J Biol Chem. 2000 May 26;275(21):16023-9 [10821856] Methods Enzymol. 2000;319:302-9 [10907522] Toxicol Appl Pharmacol. 2001 May 1;172(3):249-61 [11312654] Toxicol Sci. 2001 Jun;61(2):314-20 [11353140] Int J Biochem Cell Biol. 2001 Aug;33(8):735-53 [11404179] Toxicol Appl Pharmacol. 2001 Oct 1;176(1):64-71 [11578149] Toxicol Lett. 2002 Jul 7;133(1):1-16 [12076506] Mol Cell Biochem. 2002 May-Jun;234-235(1-2):301-8 [12162448] Environ Health Perspect. 2002 Oct;110 Suppl 5:749-52 [12426125] Environ Health Perspect. 2002 Oct;110 Suppl 5:761-6 [12426128] J Biol Chem. 2003 Mar 7;278(10):8058-64 [12502708] J Occup Environ Med. 2003 Mar;45(3):241-8 [12661181] Cancer Lett. 2003 Mar 31;192(2):151-60 [12668279] Toxicology. 2003 Jul 15;189(1-2):21-39 [12821280] Indian J Exp Biol. 2002 Nov;40(11):1213-32 [13677623] Exp Cell Res. 2003 Nov 1;290(2):234-45 [14567983] Mutat Res. 2003 Dec 10;533(1-2):37-65 [14643412] Mol Cell Biochem. 2004 Jan;255(1-2):57-66 [14971646] Mol Cell Biochem. 2004 Jan;255(1-2):67-78 [14971647] J Natl Cancer Inst. 2004 Mar 17;96(6):466-74 [15026472] Environ Health Perspect. 2004 Apr;112(5):599-603 [15064167] Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4954-9 [15041750] Toxicol Appl Pharmacol. 2004 Aug 1;198(3):253-67 [15276404] Toxicol Appl Pharmacol. 2004 Aug 1;198(3):291-6 [15276408] J Cell Biol. 1988 Mar;106(3):761-71 [2450098] Br J Dermatol. 1991 Jun;124(6):555-9 [2064938] Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2965-9 [8385353] Free Radic Biol Med. 1994 Jan;16(1):29-33 [8299992] Proc Natl Acad Sci U S A. 1994 May 10;91(10):4293-7 [8183903] J Immunol Methods. 1995 Jul 17;184(1):39-51 [7622868] Carcinogenesis. 1997 Jun;18(6):1215-23 [9214605] Mutat Res. 1997 Jun;386(3):209-18 [9219559] Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8103-7 [9653147] Am J Pathol. 1998 Dec;153(6):1775-85 [9846968] IARC Monogr Eval Carcinog Risks Hum. 2004;84:269-477 [15645578] Int J Cancer. 2005 Aug 10;116(1):20-6 [15756686] Nat Methods. 2006 Feb;3(2):123-7 [16432522] Adv Enzyme Regul. 2006;46:113-40 [16887173] Toxicol Appl Pharmacol. 2006 Nov 1;216(3):407-15 [16876216] J Invest Dermatol. 2007 Jan;127(1):222-32 [16902416] Nat Protoc. 2007;2(3):512-22 [17406615] Toxicol Appl Pharmacol. 2007 Aug 1;222(3):289-97 [17316729] Free Radic Biol Med. 2008 Sep 1;45(5):651-8 [18572023] Cancer Res. 2008 Oct 15;68(20):8278-85 [18922899] Pharmacol Res. 2008 Nov-Dec;58(5-6):262-70 [18838122] Toxicology. 2009 Aug 3;262(2):162-70 [19524636] J Natl Cancer Inst. 2009 Dec 16;101(24):1670-81 [19933942] Cell. 2000 Jan 7;100(1):57-70 [10647931] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2011.07.006 ER - TY - JOUR T1 - Interaction of celecoxib with different anti-cancer drugs is antagonistic in breast but not in other cancer cells. AN - 885903254; 21763710 AB - Celecoxib, an inhibitor of cyclooxygenase-2, is being investigated for enhancement of chemotherapy efficacy in cancer clinical trials. This study investigates the ability of cyclooxygenase-2 inhibitors to sensitize cells from different origins to several chemotherapeutic agents. The effect of the drug's mechanism of action and sequence of administration are also investigated. The sensitivity, cell cycle, apoptosis and DNA damage of five different cancer cell lines (HeLa, HCT116, HepG2, MCF7 and U251) to 5-FU, cisplatin, doxorubicin and etoposide±celecoxib following different incubation schedules were analyzed. We found antagonism between celecoxib and the four drugs in the breast cancer cells MCF7 following all incubation schedules and between celecoxib and doxorubicin in all cell lines except for two combinations in HCT116 cells. Celecoxib with the other three drugs in the remaining four cell lines resulted in variable interactions. Mechanistic investigations revealed that celecoxib exerts different molecular effects in different cells. In some lines, it abrogates the drug-induced G2/M arrest enhancing pre-mature entry into mitosis with damaged DNA thus increasing apoptosis and resulting in synergism. In other cells, it enhances drug-induced G2/M arrest allowing time to repair drug-induced DNA damage before entry into mitosis and decreasing cell death resulting in antagonism. In some synergistic combinations, celecoxib-induced abrogation of G2/M arrest was not associated with apoptosis but permanent arrest in G1 phase. These results, if confirmed in-vivo, indicate that celecoxib is not a suitable chemosensitizer for breast cancer or with doxorubicin for other cancers. Moreover, combination of celecoxib with other drugs should be tailored to the tumor type, drug and administration schedule. Copyright © 2011 Elsevier Inc. All rights reserved. JF - Toxicology and applied pharmacology AU - El-Awady, Raafat A AU - Saleh, Ekram M AU - Ezz, Marwa AU - Elsayed, Abeer M AD - Pharmacology unit, Department of Cancer Biology, National, Cancer Institute, Cairo University, Fom El-Khalig, Cairo, Egypt. relawady@sharjah.ac.ae Y1 - 2011/09/15/ PY - 2011 DA - 2011 Sep 15 SP - 271 EP - 286 VL - 255 IS - 3 KW - Antineoplastic Agents KW - 0 KW - Pyrazoles KW - Sulfonamides KW - Celecoxib KW - JCX84Q7J1L KW - Index Medicus KW - DNA Damage -- physiology KW - Hep G2 Cells KW - Cell Survival -- drug effects KW - HeLa Cells KW - Humans KW - Cell Line, Tumor KW - HCT116 Cells KW - Female KW - Drug Interactions -- physiology KW - Cell Survival -- physiology KW - DNA Damage -- drug effects KW - Sulfonamides -- metabolism KW - Pyrazoles -- metabolism KW - Pyrazoles -- pharmacology KW - Breast Neoplasms -- pathology KW - Sulfonamides -- pharmacology KW - Antineoplastic Agents -- metabolism KW - Breast Neoplasms -- metabolism KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885903254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Interaction+of+celecoxib+with+different+anti-cancer+drugs+is+antagonistic+in+breast+but+not+in+other+cancer+cells.&rft.au=El-Awady%2C+Raafat+A%3BSaleh%2C+Ekram+M%3BEzz%2C+Marwa%3BElsayed%2C+Abeer+M&rft.aulast=El-Awady&rft.aufirst=Raafat&rft.date=2011-09-15&rft.volume=255&rft.issue=3&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2011.06.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-27 N1 - Date created - 2011-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2011.06.019 ER - TY - JOUR T1 - Enhanced long-term fear memory and increased anxiety and depression-like behavior after exposure to an aversive event in mice lacking TIP39 signaling AN - 883020547; 14892770 AB - Exaggerated recall for fear-provoking events leads to abnormal behaviors. We hypothesized that tuberoinfundibular-peptide-of-39-residues (TIP39) modulates fear memory by limiting long-term consequences of aversive experiences. We now show that mice lacking TIP39 signaling display enhanced fear-recall, anxiety and depression-like behavior 2 weeks after a traumatic event. We suggest that TIP39 modulates long-term fear recall and that mice lacking TIP39 or its receptor are tools for investigating fear-related psychopathologies. JF - Behavioural Brain Research AU - Coutellier, Laurence AU - Usdin, Ted B AD - Section on Fundamental Neuroscience, NIMH, National Institutes of Health (NIH), 35 Convent Drive, 20892 Bethesda, MD, USA, usdint@mail.nih.gov Y1 - 2011/09/12/ PY - 2011 DA - 2011 Sep 12 SP - 265 EP - 269 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 222 IS - 1 SN - 0166-4328, 0166-4328 KW - Toxicology Abstracts; Animal Behavior Abstracts; CSA Neurosciences Abstracts KW - Memory KW - Anxiety KW - Fear KW - Psychopathology KW - Y 25090:Emotion and Fear KW - N3 11001:Behavioral and Cognitive Neuroscience KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883020547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+Brain+Research&rft.atitle=Enhanced+long-term+fear+memory+and+increased+anxiety+and+depression-like+behavior+after+exposure+to+an+aversive+event+in+mice+lacking+TIP39+signaling&rft.au=Coutellier%2C+Laurence%3BUsdin%2C+Ted+B&rft.aulast=Coutellier&rft.aufirst=Laurence&rft.date=2011-09-12&rft.volume=222&rft.issue=1&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Behavioural+Brain+Research&rft.issn=01664328&rft_id=info:doi/10.1016%2Fj.bbr.2011.02.043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Memory; Anxiety; Fear; Psychopathology DO - http://dx.doi.org/10.1016/j.bbr.2011.02.043 ER - TY - JOUR T1 - Studies on the effect of column angle in figure-8 centrifugal counter-current chromatography AN - 1266752943; 15591074 AB - The performance of the figure-8 column configuration in centrifugal counter-current chromatography was investigated by changing the angle between the column axis (a line through the central post and the peripheral post on which the figure-8 coil is wound) and the centrifugal force. The first series of experiments was performed using a polar two-phase solvent system composed of 1-butanol-acetic acid-water (4:1:5, v/v) to separate two dipeptide samples, Trp-Tyr and Val-Tyr, at a flow rate of 0.05 ml/min at 1000 rpm. When the column angle was changed from 0 degree (column axis parallel to the centrifugal force) to 45 degree and 45 degree to 90 degree (column axis perpendicular to the centrifugal force), peak resolution (Rs) changed from 1.93 (Sf = 37.8%) to 1.54 (Sf = 30.6%), then to 1.31 (Sf = 40.5%) with the lower mobile phase and from 1.21 (Sf = 38.8%) to 1.10 (Sf = 34.4%), then to 0.99 (Sf = 42.2%) with the upper mobile phase, respectively, where the stationary phase retention, Sf, is given in parentheses. The second series of experiments was similarly performed with a more hydrophobic two-phase solvent system composed of hexane-ethyl acetate-methanol-0.1 M hydrochloric acid (1:1:1:1, v/v) to separate three DNP-amino acids, DNP-glu, DNP- beta -ala and DNP-ala, at a flow rate of 0.05 ml/min at 1000 rpm. When the column angle was altered from 0 degree to 45 degree and 45 degree to 90 degree , Rs changed from 1.77 (1st peak/2nd peak) and 1.52 (2nd peak/3rd peak) (Sf = 27.3%) to 1.24 and 1.02 (Sf = 35.4%), then to 1.69 and 1.49 (Sf = 42.1%) with the lower mobile phase, and from 1.73 and 0.84 (SF = 41.2%) to 1.44 and 0.73 (Sf = 45.6%), then to 1.21 and 0.63 (Sf = 55.6%) with the upper mobile phase, respectively. The performance of figure-8 column at 0 degree and 90 degree was also compared at different flow rates. The results show that Rs was increased with decreased flow rate yielding the highest value at the 0 degree column angle with lower mobile phase. The overall results of our studies indicated that a 0 degree column angle for the figure-8 column enhances the mixing of two phases in the column to improve peak resolution while decreasing the stationary phase retention by interrupting the laminar flow of the mobile phase. JF - Journal of Chromatography A AU - Yang, Yi AU - Gu, Dongyu AU - Aisa, Haji Akber AU - Ito, Yoichiro Y1 - 2011/09/09/ PY - 2011 DA - 2011 Sep 09 SP - 6128 EP - 6134 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1218 IS - 36 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - Centrifugal counter-current chromatography KW - Figure-8 column KW - Angle between column axis and centrifugal force KW - Retention of the stationary phase KW - Resolution KW - Dipeptide KW - DNP-amino acid KW - Laminar Flow KW - Chromatography KW - Chromatographic techniques KW - Solvents KW - Retention KW - Mixing KW - Centrifugal force KW - Performance Evaluation KW - Flow Rates KW - Laminar flow KW - Analytical Methods KW - Acids KW - SW 5010:Network design KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266752943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Studies+on+the+effect+of+column+angle+in+figure-8+centrifugal+counter-current+chromatography&rft.au=Yang%2C+Yi%3BGu%2C+Dongyu%3BAisa%2C+Haji+Akber%3BIto%2C+Yoichiro&rft.aulast=Yang&rft.aufirst=Yi&rft.date=2011-09-09&rft.volume=1218&rft.issue=36&rft.spage=6128&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2010.11.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Centrifugal force; Laminar flow; Chromatographic techniques; Solvents; Performance Evaluation; Laminar Flow; Flow Rates; Chromatography; Analytical Methods; Acids; Retention; Mixing DO - http://dx.doi.org/10.1016/j.chroma.2010.11.014 ER - TY - JOUR T1 - Vortex counter-current chromatography AN - 1266752926; 15591072 AB - A novel counter-current chromatographic system is developed by mounting a vortex column on a type-I coil planet centrifuge. The column is fabricated from a high-density polyethylene disk (16 cm diameter and 5 cm thick) by making multiple holes of various diameters (3-12.5 mm) each arranged in a circle and connected with narrow transfer ducts. The performance of this vortex column is tested with three different two-phase solvent systems with a broad range in hydrophobicity. The results indicated that the smallest diameter column (3 mm diameter, 120 units with 42.8 ml capacity) yielded the best separation with the height equivalent to a theoretical plate of 2 cm compared with 20 cm required by the conventional multilayer coil column of high-speed CCC. By avoiding the use of an Archimedean Screw Force, the system shows a low column pressure which would permit safe operation of a large preparative column without a risk of leakage of solvent and column damage. JF - Journal of Chromatography A AU - Ito, Yoichiro AU - Ma, Zhiyong AU - Clary, Robert AU - Powell, Jimmie AU - Knight, Martha AU - Finn, Thomas M Y1 - 2011/09/09/ PY - 2011 DA - 2011 Sep 09 SP - 6165 EP - 6172 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1218 IS - 36 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - Vortex counter-current chromatography KW - Type-I coil planet centrifuge KW - Cylindrical vortex column KW - Damage KW - Leakage KW - Chromatography KW - Chromatographic techniques KW - Solvents KW - Risk KW - Performance Evaluation KW - Analytical Methods KW - Centrifuges KW - Permits KW - Capacity KW - AQ 00001:Water Resources and Supplies KW - SW 5010:Network design KW - Q5 08521:Mechanical and natural changes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266752926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Vortex+counter-current+chromatography&rft.au=Ito%2C+Yoichiro%3BMa%2C+Zhiyong%3BClary%2C+Robert%3BPowell%2C+Jimmie%3BKnight%2C+Martha%3BFinn%2C+Thomas+M&rft.aulast=Ito&rft.aufirst=Yoichiro&rft.date=2011-09-09&rft.volume=1218&rft.issue=36&rft.spage=6165&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2010.10.058 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Centrifuges; Chromatographic techniques; Solvents; Risk; Damage; Performance Evaluation; Leakage; Chromatography; Analytical Methods; Capacity; Permits DO - http://dx.doi.org/10.1016/j.chroma.2010.10.058 ER - TY - JOUR T1 - Simple, Direct Conjugation of Bacterial O-SP--Core Antigens to Proteins: Development of Cholera Conjugate Vaccines AN - 1776644511; 16063962 AB - Bacterial O-SP--core antigens can be conjugated to proteins in the same, simple way as synthetic, linker-equipped carbohydrates by applying squaric acid chemistry. Introduction of spacers (linkers) to either O-SP--core antigens or protein carriers, which is involved in commonly applied protocols, is not required. The newly developed method described here consists of preparation of a squaric acid monoester derivative of O-SP--core antigen, utilizing the amino group inherent in the core, and reaction of the monoester with the carrier protein. The intermediate monoester can be easily purified; its conjugation can be monitored by SELDI-TOF mass spectrometry and, thus, readily controlled, since the conjugation can be terminated when the desired carbohydrate--protein ratio is reached. Here, we describe production of conjugates containing the O-SP--core antigen of Vibrio cholerae O1, the major cause of cholera, a severe dehydrating diarrheal disease of humans. The resultant products are recognized by convalescent phase sera from patients recovering from cholera in Bangladesh, and anti-O-SP-core-protein responses correlate with plasma antilipopolysaccharide and vibriocidal responses, which are the primary markers of protection from cholera. The results suggest that such conjugates have potential as vaccines for cholera and other bacterial diseases. JF - Bioconjugate Chemistry AU - Xu, Peng AU - Alam, Mohammad Murshid AU - Kalsy, Anuj AU - Charles, Richelle C AU - Calderwood, Stephen B AU - Qadri, Firdausi AU - Ryan, Edward T AU - Kovac, Pavol AD - NIDDK, LBC, National Institutes of Health, 8 Center Drive, Bethesda, Maryland 20892-0815, United States Y1 - 2011/09/08/ PY - 2011 DA - 2011 Sep 08 SP - 2179 EP - 2185 VL - 22 IS - 10 SN - 1043-1802, 1043-1802 KW - Microbiology Abstracts B: Bacteriology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - ISW, Bangladesh KW - Amino groups KW - Conjugation KW - Diarrhea KW - Pathogenic bacteria KW - Bacterial diseases KW - Disease control KW - Spacer KW - Mass spectroscopy KW - Public health KW - Vibrio cholerae KW - Antigens KW - Proteins KW - Cholera KW - Vaccines KW - Carbohydrates KW - Q1 08423:Behaviour KW - J 02400:Human Diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776644511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+Chemistry&rft.atitle=Simple%2C+Direct+Conjugation+of+Bacterial+O-SP--Core+Antigens+to+Proteins%3A+Development+of+Cholera+Conjugate+Vaccines&rft.au=Xu%2C+Peng%3BAlam%2C+Mohammad+Murshid%3BKalsy%2C+Anuj%3BCharles%2C+Richelle+C%3BCalderwood%2C+Stephen+B%3BQadri%2C+Firdausi%3BRyan%2C+Edward+T%3BKovac%2C+Pavol&rft.aulast=Xu&rft.aufirst=Peng&rft.date=2011-09-08&rft.volume=22&rft.issue=10&rft.spage=2179&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+Chemistry&rft.issn=10431802&rft_id=info:doi/10.1021%2Fbc2001984 L2 - http://pubs.acs.org/doi/abs/10.1021/bc2001984 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Conjugation; Antigens; Pathogenic bacteria; Bacterial diseases; Disease control; Proteins; Carbohydrates; Vaccines; Public health; Amino groups; Diarrhea; Spacer; Cholera; Mass spectroscopy; Vibrio cholerae; ISW, Bangladesh DO - http://dx.doi.org/10.1021/bc2001984 ER - TY - JOUR T1 - Personality and obesity across the adult life span AN - 911912117; 4256373 AB - Personality traits contribute to health outcomes, in part through their association with major controllable risk factors, such as obesity. Body weight, in turn, reflects our behaviors and lifestyle and contributes to the way we perceive ourselves and others. In this study, the authors use data from a large (N = 1,988) longitudinal study that spanned more than 50 years to examine how personality traits are associated with multiple measures of adiposity and with fluctuations in body mass index (BMI). Using 14,531 anthropometric assessments, the authors modeled the trajectory of BMI across adulthood and tested whether personality predicted its rate of change. Measured concurrently, participants higher on Neuroticism or Extraversion or lower on Conscientiousness had higher BMI; these associations replicated across body fat, waist, and hip circumference. The strongest association was found for the impulsivity facet: Participants who scored in the top 10% of impulsivity weighed, on average, 11Kg more than those in the bottom 10%. Longitudinally, high Neuroticism and low Conscientiousness, and the facets of these traits related to difficulty with impulse control, were associated with weight fluctuations, measured as the variability in weight over time. Finally, low Agreeableness and impulsivity-related traits predicted a greater increase in BMI across the adult life span. BMI was mostly unrelated to change in personality traits. Personality traits are defined by cognitive, emotional, and behavioral patterns that likely contribute to unhealthy weight and difficulties with weight management. Such associations may elucidate the role of personality traits in disease progression and may help to design more effective interventions. [Copyright The American Psychological Association.] Reprinted by permission of the American Psychological Association JF - Journal of personality and social psychology AU - Sutin, Angelina R AU - Ferrucci, Luigi AU - Zonderman, Alan B AU - Terracciano, Antonio AD - National Institutes of Health Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 579 EP - 592 VL - 101 IS - 3 SN - 0022-3514, 0022-3514 KW - Sociology KW - Obesity KW - Body KW - Neuroses KW - Personality traits KW - Personality KW - Adults KW - Diseases KW - Life styles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911912117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality+and+social+psychology&rft.atitle=Personality+and+obesity+across+the+adult+life+span&rft.au=Sutin%2C+Angelina+R%3BFerrucci%2C+Luigi%3BZonderman%2C+Alan+B%3BTerracciano%2C+Antonio&rft.aulast=Sutin&rft.aufirst=Angelina&rft.date=2011-09-01&rft.volume=101&rft.issue=3&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality+and+social+psychology&rft.issn=00223514&rft_id=info:doi/10.1037%2Fa0024286 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9416 2153; 8823; 1678; 9429 9416 2153; 3617 6220; 8638 7951 6220 7954; 7404; 603 DO - http://dx.doi.org/10.1037/a0024286 ER - TY - JOUR T1 - Antibody Profiling of Borrelia burgdorferi Infection in Horses AN - 911161036; 16063097 AB - Infection with Borrelia burgdorferi is common in horses and ponies from the New England and mid-Atlantic regions of the United States. Here, we evaluated luciferase immunoprecipitation systems (LIPS) for profiling antibody responses against three different antigenic targets for the diagnosis of equine B. burgdorferi infection. LIPS testing of horse serum samples suspected of Lyme infection revealed that approximately 75% of the horse samples (114/159) were seropositive against the synthetic VOVO antigen, comprising repeated immunodominant C6 epitopes as well as OspC immunodominant epitopes. A comparison of VOVO and immunofluorescence assays (IFA) showed that 51% of the samples were positive in both assays (VOVO+/IFA+), 13% were VOVO-/IFA+, 21% were VOVO+/IFA-, and 15% were negative in both. To further understand humoral responses to B. burgdorferi and reconcile the diagnostic differences between IFA and VOVO, two additional B. burgdorferi LIPS tests were performed with DbpA and DbpB. Robust seropositive antibody responses against DbpA and/or DbpB were detected in 98% (79/81) of the VOVO+/IFA+ and 93% (50/54) of the discrepant samples. Additionally, some of the samples negative by both VOVO and IFA showed immunoreactivity against DbpA and/or DbpB. Overall, 94% of the suspected horse samples were seropositive by LIPS, and heat map analysis revealed that seropositive samples often were immunoreactive with at least two of the three antigens. These results suggest that LIPS tests employing multiple recombinant antigens offer a promising approach for the evaluation of antibody responses in Lyme disease. JF - Clinical and Vaccine Immunology AU - Burbelo, Peter D AU - Bren, Kathleen E AU - Ching, Kathryn H AU - Coleman, Adam AU - Yang, Xiuli AU - Kariu, Toru AU - Iadarola, Michael J AU - Pal, Utpal AD - Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, burbelop@nidcr.nih.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1562 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 18 IS - 9 SN - 1556-679X, 1556-679X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Antibodies KW - Borrelia burgdorferi KW - Heat KW - Immunoreactivity KW - Immunoprecipitation KW - Immunofluorescence KW - Infection KW - Epitopes KW - Lyme disease KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911161036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Antibody+Profiling+of+Borrelia+burgdorferi+Infection+in+Horses&rft.au=Burbelo%2C+Peter+D%3BBren%2C+Kathleen+E%3BChing%2C+Kathryn+H%3BColeman%2C+Adam%3BYang%2C+Xiuli%3BKariu%2C+Toru%3BIadarola%2C+Michael+J%3BPal%2C+Utpal&rft.aulast=Burbelo&rft.aufirst=Peter&rft.date=2011-09-01&rft.volume=18&rft.issue=9&rft.spage=1562&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.05123-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Antibodies; Heat; Immunoreactivity; Immunoprecipitation; Immunofluorescence; Infection; Epitopes; Lyme disease; Borrelia burgdorferi DO - http://dx.doi.org/10.1128/CVI.05123-11 ER - TY - JOUR T1 - Structure and function of RapA: A bacterial Swi2/Snf2 protein required for RNA polymerase recycling in transcription AN - 910785740; 15720943 AB - One of the hallmarks of the Swi2/Snf2 family members is their ability to modify the interaction between DNA-binding protein and DNA in controlling gene expression. The studies of Swi2/Snf2 have been mostly focused on their roles in chromatin and/or nucleosome remodeling in eukaryotes. A bacterial Swi2/Snf2 protein named RapA from Escherichia coli is a unique addition to these studies. RapA is an RNA polymerase (RNAP)-associated protein and an ATPase. It binds nucleic acids including RNA and DNA. The ATPase activity of RapA is stimulated by its interaction with RNAP, but not with nucleic acids. RapA and the major sigma factor Ief70 compete for binding to core RNAP. After one transcription cycle in vitro, RNAP is immobilized in an undefined posttranscription/posttermination complex (PTC), thus becoming unavailable for reuse. RapA stimulates RNAP recycling by ATPase-dependent remodeling of PTC, leading to the release of sequestered RNAP, which then becomes available for reuse in another cycle of transcription. Recently, the crystal structure of RapA that is also the first full-length structure for the entire Swi2/Snf2 family was determined. The structure provides a framework for future studies of the mechanism of RNAP recycling in transcription. This article is part of a Special Issue entitled: Snf2/Swi2 ATPase structure and function. JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms AU - Jin, Ding Jun AU - Zhou, Yan Ning AU - Shaw, Gary AU - Ji, Xinhua Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 470 EP - 475 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 1809 IS - 9 SN - 1874-9399, 1874-9399 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - Adenosinetriphosphatase KW - Chromatin KW - Crystal structure KW - Cycle protein KW - DNA-binding protein KW - DNA-directed RNA polymerase KW - Gene expression KW - Nucleosomes KW - Recycling KW - Sigma factor KW - Snf2 protein KW - Structure-function relationships KW - Transcription KW - nucleic acids KW - Escherichia coli KW - J 02310:Genetics & Taxonomy KW - N 14820:DNA Metabolism & Structure KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/910785740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+Biophysica+Acta+-+Gene+Regulatory+Mechanisms&rft.atitle=Structure+and+function+of+RapA%3A+A+bacterial+Swi2%2FSnf2+protein+required+for+RNA+polymerase+recycling+in+transcription&rft.au=Jin%2C+Ding+Jun%3BZhou%2C+Yan+Ning%3BShaw%2C+Gary%3BJi%2C+Xinhua&rft.aulast=Jin&rft.aufirst=Ding&rft.date=2011-09-01&rft.volume=1809&rft.issue=9&rft.spage=470&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+Biophysica+Acta+-+Gene+Regulatory+Mechanisms&rft.issn=18749399&rft_id=info:doi/10.1016%2Fj.bbagrm.2011.03.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-05-18 N1 - SubjectsTermNotLitGenreText - Adenosinetriphosphatase; Cycle protein; Chromatin; DNA-binding protein; Transcription; Recycling; Gene expression; DNA-directed RNA polymerase; Nucleosomes; nucleic acids; Structure-function relationships; Crystal structure; Sigma factor; Snf2 protein; Escherichia coli DO - http://dx.doi.org/10.1016/j.bbagrm.2011.03.003 ER - TY - JOUR T1 - Connecting Contemporary Paradigms to the Social Security Administration's Disability Evaluation Process AN - 908014581; 2011-142317 AB - From 1998 to 2008, the Social Security Administration's (SSA) disability insurance program (DI) applications rose from 1.2 million to 2.3 million and exceeded 3 million in 2009. Given these large and growing numbers, even small changes in processing disability applications may reduce processing time, lower program costs, and improve performance of SSA's disability programs. A literature review examining current conceptual models of disability and SSA's disability evaluation process for adults was conducted. A gap exists between contemporary models of disability and how SSA defines and operationalizes disability. This is complicated by substantial variation in the timing, quantity, and quality of applicant functional information and workplace demands. A focus on impairment marginalizes more comprehensive assessment of function necessary to assess capacity for work. Novel assessment methodologies, such as computer adaptive testing to measure human functioning may hold promise for SSA's data collection methods and disability assessment. Adapted from the source document. JF - Journal of Disability Policy Studies AU - Brandt, Diane E AU - Houtenville, Andrew J AU - Huynh, Minh T AU - Chan, Leighton AU - Rasch, Elizabeth K AD - National Institutes of Health Clinical Research Center, Bethesda, MD, USA brandtdi@cc.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 116 EP - 128 PB - PRO-ED, Austin TX VL - 22 IS - 2 SN - 1044-2073, 1044-2073 KW - Social conditions and policy - Social policy and social development KW - Population groups, population policy, and demographics - Disabled KW - Business and service sector - Personnel management KW - Manufacturing and heavy industry - Industrial management, production, and productivity KW - Business and service sector - Business operations, practices, and workplaces KW - Science and technology policy - Computer science and information technology KW - Economic conditions and policy - Economic theory KW - Population groups, population policy, and demographics - Demography and census KW - Business and service sector - Insurance KW - Health conditions and policy - Health and health policy KW - disability evaluation Social Security Administration impairment functional ability KW - Cost KW - Disability insurance KW - Computers KW - Disabled KW - Adults KW - Performance KW - Workplaces KW - Social policy KW - Social insurance KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/908014581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Disability+Policy+Studies&rft.atitle=Connecting+Contemporary+Paradigms+to+the+Social+Security+Administration%27s+Disability+Evaluation+Process&rft.au=Brandt%2C+Diane+E%3BHoutenville%2C+Andrew+J%3BHuynh%2C+Minh+T%3BChan%2C+Leighton%3BRasch%2C+Elizabeth+K&rft.aulast=Brandt&rft.aufirst=Diane&rft.date=2011-09-01&rft.volume=22&rft.issue=2&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Journal+of+Disability+Policy+Studies&rft.issn=10442073&rft_id=info:doi/10.1177%2F1044207310396509 LA - English DB - PAIS Index N1 - Date revised - 2011-12-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JDPSEH N1 - SubjectsTermNotLitGenreText - Social policy; Disabled; Social insurance; Performance; Workplaces; Computers; Cost; Adults; Disability insurance DO - http://dx.doi.org/10.1177/1044207310396509 ER - TY - JOUR T1 - Eating the strangers within: host control of intracellular bacteria via xenophagy AN - 904491022; 15632048 AB - Many bacterial pathogens rely on an intracellular cycle to ensure their proliferation within infected hosts, through their ability to avoid or circumvent host bactericidal pathways. Recent evidence supports an increasingly important role for the autophagy pathway in innate immune defences against intracellular pathogens, as a mechanism of capture of either cytosol-adapted or vacuolar bacteria that redirect them to the lysosomal compartment for killing. Antibacterial autophagy, also referred to as xenophagy, involves selective recognition of intracellular bacteria and their targeting to the autophagic machinery for degradation. Here we review recent advances in our molecular understanding of these processes, and in how bacteria have adapted to avoid xenophagy or even take advantage of this innate immune process. JF - Cellular Microbiology AU - Knodler, Leigh A AU - Celli, Jean AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1319 EP - 1327 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 13 IS - 9 SN - 1462-5814, 1462-5814 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Pathogens KW - Phagocytosis KW - Reviews KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904491022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Microbiology&rft.atitle=Eating+the+strangers+within%3A+host+control+of+intracellular+bacteria+via+xenophagy&rft.au=Knodler%2C+Leigh+A%3BCelli%2C+Jean&rft.aulast=Knodler&rft.aufirst=Leigh&rft.date=2011-09-01&rft.volume=13&rft.issue=9&rft.spage=1319&rft.isbn=&rft.btitle=&rft.title=Cellular+Microbiology&rft.issn=14625814&rft_id=info:doi/10.1111%2Fj.1462-5822.2011.01632.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Document feature - figure 2 N1 - Last updated - 2012-07-27 N1 - SubjectsTermNotLitGenreText - Reviews; Pathogens; Phagocytosis DO - http://dx.doi.org/10.1111/j.1462-5822.2011.01632.x ER - TY - JOUR T1 - A developmental shift in Black-White differences in depressive affect across adolescence and early adulthood: The influence of early adult social roles and socio-economic status AN - 902097770; 201119742 AB - This study examined Black-White differences in growth of depressive affect using a longitudinal sample of middle-class, suburban U.S. subjects (n = 956) that spanned from adolescence to early adulthood. Specifically, this study examined whether Black-White differences in growth of depressive affect shift over time, and the extent to which that shift, if any, was associated with racial differences in the rate and mental health consequences of early adult social roles (e.g., living arrangements, work/college status, and single parenthood) and socioeconomic status (SES). As expected, growth in depressive affect pivoted around the onset of early adulthood, with the trajectory pivoting upward for Black Americans and downward for White Americans. Due to deficits in SES, the relation between challenging early adult social roles-under/unemployment in particular-and growth in depressive affect was more positive for Black Americans. This differential 'vulnerability' appears to underlie racial differences in early adult growth (and by connection contribute to racial differences in growth pivot). The extent to which Black Americans were at a greater risk (relative to White Americans) for an upward pivot increased as the number of challenging roles increased. Black Americans facing only optimal early adult social roles were not at a greater risk, while those facing only challenging social roles were at the greatest risk. Adapted from the source document. JF - International Journal of Behavioral Development AU - Jager, Justin AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, USA jagerjo@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 457 EP - 469 PB - Sage Publications, Thousand Oaks, CA VL - 35 IS - 5 SN - 0165-0254, 0165-0254 KW - cumulative risk early adulthood mental health piece-wise growth curve modeling race KW - Racial differences KW - Black American people KW - Social roles KW - Depression KW - Socioeconomic status KW - Adulthood KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902097770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Behavioral+Development&rft.atitle=A+developmental+shift+in+Black-White+differences+in+depressive+affect+across+adolescence+and+early+adulthood%3A+The+influence+of+early+adult+social+roles+and+socio-economic+status&rft.au=Jager%2C+Justin&rft.aulast=Jager&rft.aufirst=Justin&rft.date=2011-09-01&rft.volume=35&rft.issue=5&rft.spage=457&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Behavioral+Development&rft.issn=01650254&rft_id=info:doi/10.1177%2F0165025411417504 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-11-02 N1 - Number of references - 87 N1 - Last updated - 2016-09-27 N1 - CODEN - IJBDDY N1 - SubjectsTermNotLitGenreText - Depression; Socioeconomic status; Black American people; Social roles; Adulthood; Racial differences DO - http://dx.doi.org/10.1177/0165025411417504 ER - TY - JOUR T1 - Relation of Study Design to Recruitment and Retention in CTN Trials AN - 902079943; 201123888 AB - Background: Recruitment and retention in randomized clinical trials are difficult in general and particularly so in trials of substance abuse treatments. Understanding trial design characteristics that could affect recruitment and retention rates would help in the design of future trials. Objective: To test whether any of the following factors are associated with recruitment or retention: type of intervention, type of therapy, duration of treatment, total duration of trial, number of treatment sessions, number of follow-up visits, number of primary assessments, timing of primary assessments, number of case report form (CRF) pages at baseline, and number of CRF pages for the entire trial. Methods: Recruitment and retention data from 24 Clinical Trials Network (CTN) trials conducted and completed between 2001 and 2010 were analyzed using single-factor analysis of variance and single-predictor regression methods to test their association with trial design characteristics. Results: Almost all of the analyses performed did not show statistically significant patterns between recruitment and retention rates and the trial design characteristics considered. Conclusion: In CTN trials, the relationship between assessment burden on participants and length of trial, on the one hand, and recruitment and retention, on the other, is not as strong and direct as expected. Other factors must impinge on the conduct of the trial to influence trial participation. Scientific Significance: Researchers may deem slightly more justifiable to permit inclusion of some of the design features that previously were assumed to have a strong, negative influence on recruitment and retention, and should consider other strategies that may have a stronger, more direct effect on trial participation. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Wakim, Paul G AU - Rosa, Carmen AU - Kothari, Prasad AU - Michel, Mary Ellen AD - Center for the Clinical Trials Network, National Institute on Drug Abuse, Maryland, USA pwakim@nida.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 426 EP - 433 PB - Taylor & Francis Inc., Philadelphia, PA VL - 37 IS - 5 SN - 0095-2990, 0095-2990 KW - primary outcome, treatment exposure, case report form (CRF), trial design characteristics KW - Substance Abuse KW - Participation KW - Attrition KW - Recruitment KW - Intervention KW - Medical Research KW - Treatment Methods KW - Trials KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902079943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Relation+of+Study+Design+to+Recruitment+and+Retention+in+CTN+Trials&rft.au=Wakim%2C+Paul+G%3BRosa%2C+Carmen%3BKothari%2C+Prasad%3BMichel%2C+Mary+Ellen&rft.aulast=Wakim&rft.aufirst=Paul&rft.date=2011-09-01&rft.volume=37&rft.issue=5&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/10.3109%2F00952990.2011.596972 LA - English DB - Sociological Abstracts N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-28 N1 - CODEN - AJDABD N1 - SubjectsTermNotLitGenreText - Trials; Attrition; Recruitment; Treatment Methods; Participation; Medical Research; Intervention; Substance Abuse DO - http://dx.doi.org/10.3109/00952990.2011.596972 ER - TY - JOUR T1 - An automated point-of-care system for immunodetection of staphylococcal enterotoxin B AN - 899151668; 15316177 AB - An automated point-of-care (POC) immunodetection system for immunological detection of staphylococcal enterotoxin B (SEB) was designed, fabricated, and tested. The system combines several elements: (i) enzyme-linked immunosorbent assay-lab-on-a-chip (ELISA-LOC) with fluidics, (ii) a charge-coupled device (CCD) camera detector, (iii) pumps and valves for fluid delivery to the ELISA-LOC, (iv) a computer interface board, and (v) a computer for controlling the fluidics, logging, and data analysis of the CCD data. The ELISA-LOC integrates a simple microfluidic system into a miniature 96-well sample plate, allowing the user to carry out immunological assays without a laboratory. The analyte is measured in a sandwich ELISA assay format combined with a sensitive electrochemiluminescence (ECL) detection method. Using the POC system, SEB, a major foodborne toxin, was detected at concentrations as low as 0.1 ng/ml. This is similar to the reported sensitivity of conventional ELISA. The open platform with simple modular fluid delivery automation design described here is interchangeable between detection systems, and because of its versatility it can also be used to automate many other LOC systems, simplifying LOC development. This new POC system is useful for carrying out various immunological and other complex medical assays without a laboratory and can easily be adapted for high-throughput biological screening in remote and resource-poor areas. JF - Analytical Biochemistry AU - Yang, Minghui AU - Sun, Steven AU - Kostov, Yordan AU - Rasooly, Avraham AD - Center for Advanced Sensor Technology, University of Maryland Baltimore County, Baltimore, MD 21250, USA, rasoolya@mail.nih.gov PY - 2011 SP - 74 EP - 81 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 416 IS - 1 SN - 0003-2697, 0003-2697 KW - Microbiology Abstracts B: Bacteriology KW - Point of care KW - ELISA KW - Lab-on-a-chip KW - Open platform KW - CCD KW - Microfabrication KW - Staphylococcal enterotoxins KW - Food safety KW - Logging KW - Enzyme-linked immunosorbent assay KW - Microfluidics KW - Data processing KW - Computers KW - Food KW - Cameras KW - Automation KW - Staphylococcal enterotoxin B KW - Immunosorbents KW - Toxins KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899151668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=An+automated+point-of-care+system+for+immunodetection+of+staphylococcal+enterotoxin+B&rft.au=Yang%2C+Minghui%3BSun%2C+Steven%3BKostov%2C+Yordan%3BRasooly%2C+Avraham&rft.aulast=Yang&rft.aufirst=Minghui&rft.date=2011-09-01&rft.volume=416&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/10.1016%2Fj.ab.2011.05.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2016-01-06 N1 - SubjectsTermNotLitGenreText - Logging; Microfluidics; Enzyme-linked immunosorbent assay; Data processing; Food; Computers; Cameras; Automation; Staphylococcal enterotoxin B; Toxins; Immunosorbents DO - http://dx.doi.org/10.1016/j.ab.2011.05.014 ER - TY - JOUR T1 - How to amend land subsidence treatment policies to solve coastal subsidence problems in Taiwan AN - 899148005; 15578396 AB - Coastal land subsidence is a serious problem in Taiwan. Starting in 1995, the goal of the "Land Subsidence Prevention and Treatment Implementation Program" is to restructure the aquaculture industry to reduce groundwater consumption and reduce coastal land subsidence problems. However, this goal has not been met. This study aims to determine the reasons for its failure through a literature review and an analysis of questionnaires of stakeholders taken over a 5-year period, and design a new program to resolve these problems. The study was conducted in 2005-2009. According to the literature, over-pumping of groundwater around densely concentrated coastal fish ponds is the primary cause of coastal land subsidence. However, the key measure of the program was to establish aquaculture districts primarily in subsiding coastal areas, which failed to reduce land subsidence. In addition, the program did not consider reductions in agricultural and industrial groundwater use. Results of the questionnaire survey were in accord with the literature review results. This paper proposes to establish a "Fish Farming Abandonment Program" offering compensation payments and job training to fish farmers who leave the aquaculture business, thus reducing the amount of coastal land devoted to fish farming, decreasing groundwater consumption, and halting further coastal subsidence. In addition, the proposal also suggests adjustments to the structure of the agriculture industry. The results of this study can serve as a reference for governments of Taiwan and other countries. JF - Regional Environmental Change AU - Sun, Peter Lin AU - Yang, Chun-Chou AU - Lin, Tai-Wai AD - Institute of Aquaculture, National Pingtung University of Science and Technology, Nei-Pu, Pingtung, 91207, Taiwan, ROC Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 679 EP - 691 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 11 IS - 3 SN - 1436-3798, 1436-3798 KW - ASFA 1: Biological Sciences & Living Resources; ASFA Aquaculture Abstracts; Sustainability Science Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Meteorological & Geoastrophysical Abstracts KW - Agriculture KW - Marine KW - Training KW - Climate change KW - Pond culture KW - Aquaculture KW - Ponds KW - Coastal zone KW - Aquaculture enterprises KW - ISEW, Taiwan KW - Coastal subsidence KW - Literature reviews KW - Reviews KW - Subsidence KW - environmental changes KW - prevention KW - Fish KW - Marine aquaculture KW - Groundwater KW - Land subsidence KW - Fish culture KW - Fish ponds KW - Q5 08503:Characteristics, behavior and fate KW - M3 1010:Issues in Sustainable Development KW - Q3 08582:Fish culture KW - Q1 08121:Law, policy, economics and social sciences KW - M2 556.3:Groundwater Hydrology (556.3) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899148005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regional+Environmental+Change&rft.atitle=How+to+amend+land+subsidence+treatment+policies+to+solve+coastal+subsidence+problems+in+Taiwan&rft.au=Sun%2C+Peter+Lin%3BYang%2C+Chun-Chou%3BLin%2C+Tai-Wai&rft.aulast=Sun&rft.aufirst=Peter&rft.date=2011-09-01&rft.volume=11&rft.issue=3&rft.spage=679&rft.isbn=&rft.btitle=&rft.title=Regional+Environmental+Change&rft.issn=14363798&rft_id=info:doi/10.1007%2Fs10113-010-0199-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Aquaculture enterprises; Coastal zone; Literature reviews; Climate change; Subsidence; Pond culture; Marine aquaculture; Fish culture; Fish ponds; Agriculture; Coastal subsidence; Land subsidence; Training; Reviews; prevention; environmental changes; Fish; Groundwater; Aquaculture; Ponds; ISEW, Taiwan; Marine DO - http://dx.doi.org/10.1007/s10113-010-0199-0 ER - TY - JOUR T1 - RISKY SINGLE-OCCASION DRINKING AN - 899138358; 15730935 JF - Addiction AU - Dawson, Deborah A AD - Kelly Government Services Contractor to the National Institute on Alcohol Abuse and Alcoholism National Institutes of Health, Bethesda, MD, USA, E-mail: ddawsonillco.niaaa.nih.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1709 EP - 1710 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 106 IS - 9 SN - 0965-2140, 0965-2140 KW - Risk Abstracts KW - Alcohol KW - Risk taking KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899138358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=RISKY+SINGLE-OCCASION+DRINKING&rft.au=Dawson%2C+Deborah+A&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2011-09-01&rft.volume=106&rft.issue=9&rft.spage=1709&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2011.03530.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Document feature - figure 0 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Alcohol; Risk taking DO - http://dx.doi.org/10.1111/j.1360-0443.2011.03530.x ER - TY - JOUR T1 - Designing prospective cohort studies for assessing reproductive and developmental toxicity during sensitive windows of human reproduction and development--the LIFE Study. AN - 893723328; 21819423 AB - The relationship between the environment and human fecundity and fertility remains virtually unstudied from a couple-based perspective in which longitudinal exposure data and biospecimens are captured across sensitive windows. In response, we completed the LIFE Study with methodology that intended to empirically evaluate a priori purported methodological challenges: implementation of population-based sampling frameworks suitable for recruiting couples planning pregnancy; obtaining environmental data across sensitive windows of reproduction and development; home-based biospecimen collection; and development of a data management system for hierarchical exposome data. We used two sampling frameworks (i.e., fish/wildlife licence registry and a direct marketing database) for 16 targeted counties with presumed environmental exposures to persistent organochlorine chemicals to recruit 501 couples planning pregnancies for prospective longitudinal follow-up while trying to conceive and throughout pregnancy. Enrolment rates varied from <1% of the targeted population (n = 424,423) to 42% of eligible couples who were successfully screened; 84% of the targeted population could not be reached, while 36% refused screening. Among enrolled couples, ∼ 85% completed daily journals while trying; 82% of pregnant women completed daily early pregnancy journals, and 80% completed monthly pregnancy journals. All couples provided baseline blood/urine samples; 94% of men provided one or more semen samples and 98% of women provided one or more saliva samples. Women successfully used urinary fertility monitors for identifying ovulation and home pregnancy test kits. Couples can be recruited for preconception cohorts and will comply with intensive data collection across sensitive windows. However, appropriately sized sampling frameworks are critical, given the small percentage of couples contacted found eligible and reportedly planning pregnancy at any point in time. © Published 2011. This article is a US Government work and is in the public domain in the USA. JF - Paediatric and perinatal epidemiology AU - Buck Louis, Germaine M AU - Schisterman, Enrique F AU - Sweeney, Anne M AU - Wilcosky, Timothy C AU - Gore-Langton, Robert E AU - Lynch, Courtney D AU - Boyd Barr, Dana AU - Schrader, Steven M AU - Kim, Sungduk AU - Chen, Zhen AU - Sundaram, Rajeshwari AD - Division of Epidemiology, Statistics & Prevention Research, Eunice Kennedy Shriver National Institute of Child Health & Human Development, NIH, Rockville, MD20852, USA. louisg@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 413 EP - 424 VL - 25 IS - 5 KW - Environmental Pollutants KW - 0 KW - Hydrocarbons, Chlorinated KW - Index Medicus KW - Young Adult KW - Hydrocarbons, Chlorinated -- blood KW - Epidemiologic Methods KW - Humans KW - Semen -- chemistry KW - Hydrocarbons, Chlorinated -- urine KW - Fetal Development -- drug effects KW - Pregnancy KW - Prospective Studies KW - Adult KW - Cohort Studies KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Maternal Exposure -- adverse effects KW - Reproduction -- drug effects KW - Environmental Pollutants -- urine KW - Environmental Exposure -- adverse effects KW - Research Design KW - Environmental Pollutants -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893723328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Paediatric+and+perinatal+epidemiology&rft.atitle=Designing+prospective+cohort+studies+for+assessing+reproductive+and+developmental+toxicity+during+sensitive+windows+of+human+reproduction+and+development--the+LIFE+Study.&rft.au=Buck+Louis%2C+Germaine+M%3BSchisterman%2C+Enrique+F%3BSweeney%2C+Anne+M%3BWilcosky%2C+Timothy+C%3BGore-Langton%2C+Robert+E%3BLynch%2C+Courtney+D%3BBoyd+Barr%2C+Dana%3BSchrader%2C+Steven+M%3BKim%2C+Sungduk%3BChen%2C+Zhen%3BSundaram%2C+Rajeshwari&rft.aulast=Buck+Louis&rft.aufirst=Germaine&rft.date=2011-09-01&rft.volume=25&rft.issue=5&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Paediatric+and+perinatal+epidemiology&rft.issn=1365-3016&rft_id=info:doi/10.1111%2Fj.1365-3016.2011.01205.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-20 N1 - Date created - 2011-08-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Health Soc Behav. 1983 Dec;24(4):385-96 [6668417] Fertil Steril. 2004 Feb;81(2):384-92 [14967378] Hum Reprod. 1996 Feb;11(2):406-12 [8671233] Paediatr Perinat Epidemiol. 1997 Jul;11(3):345-58 [9246695] Reprod Toxicol. 1998 Jan-Feb;12(1):19-27 [9431569] Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50 [16103423] Epidemiology. 2006 Jul;17(4):440-9 [16755258] Hum Reprod. 2007 Jun;22(6):1634-7 [17344224] Fertil Steril. 2008 Feb;89(2 Suppl):e119-21 [18308052] Am J Epidemiol. 2009 Jan 1;169(1):105-12 [18974081] Hum Reprod. 2009 Feb;24(2):451-8 [18940895] Acta Obstet Gynecol Scand. 2000 Jan;79(1):43-8 [10646815] Hum Reprod. 2000 Dec;15(12):2478-82 [11098014] Hum Reprod. 2001 May;16(5):972-8 [11331648] Fertil Steril. 2003 May;79(5):1136-40 [12738508] Environ Health Perspect. 2004 Jan;112(1):79-86 [14698935] Am J Obstet Gynecol. 2004 Jan;190(1):100-5 [14749643] J Occup Med. 1989 Dec;31(12):980-5 [2614538] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-3016.2011.01205.x ER - TY - JOUR T1 - Insecticide Residues in Eggplant Fruits, Soil, and Water in the Largest Eggplant-Producing Area in the Philippines AN - 888100410; 15454168 AB - This study looked into the insecticide residues in eggplant, soil, and water samples in the largest eggplant-producing community in the Philippines as well as to analyze the fate of insecticides. The study area consisted of eggplant farms in a community in the largest eggplant producer in the Philippines. A total of 20 of the environmental samples were taken from the farms and analyzed using gas chromatography. The samples were distributed spatially over a mean distance of 451 m (s.d.=20.2 m). For eggplant pesticide application, the mean spraying time of the farmers was 1.4 (sdv=0.53)h/day, 4.13 (sdv=1.9)days/week, 3.79 (sdv=0.22)weeks/month, and 1 year/cropping season. Forty percent of the farm samples of eggplants had positive reading of insecticides cypermethrin and chlorpyrifos between 0.02 and 0.03 mg/kg. There was no positive reading for the 20 water samples. There was only one positive reading of chlorpyrifos in one farm out of 20 soil samples at 0.03 mg/kg. Although Prevathon and Malathion were used by all the farms for eggplant pesticide application, the liter-years of exposure to pesticide was very low for both (0.06, 0.56). Although Brodan and Magnum were not prevalently used, they had the highest liter-years of exposure to pesticide at 4.73 for chlorpyrifos, and 6.09 for cypermethrin. The amount and duration of use of insecticide is important in the determination of its persistence in vegetables and in the environment. In this study, Brodan was the largest and longest used insecticide for eggplants which explains why there was reading for both cypermethrin and chlorpyrifos in the eggplants, but none for Malathion and chlorantraniliprole. The presence of insecticide in water, soil, and plants is also based on its environmental fate. Pesticide regulation and pesticide residue monitoring have been pursued to varying degrees of success in the Philippines, but implementation is considered inadequate. The study also suggests for better implementation of pesticide regulation. JF - Water, Air, & Soil Pollution AU - Lu, Jinky Leilanie AD - National Institutes of Health, University of the Philippines Manila, NIH Bldg, P. Gil Street, Ermita, Manila, Philippines, 1100, jinkyULlu@yahoo.com Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 413 EP - 422 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 220 IS - 1-4 SN - 0049-6979, 0049-6979 KW - Meteorological & Geoastrophysical Abstracts; Environment Abstracts; Pollution Abstracts KW - Atmospheric pollution KW - Soil pollution KW - Philippines KW - farms KW - M2:551.5 KW - P 2000:FRESHWATER POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888100410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water%2C+Air%2C+%26+Soil+Pollution&rft.atitle=Insecticide+Residues+in+Eggplant+Fruits%2C+Soil%2C+and+Water+in+the+Largest+Eggplant-Producing+Area+in+the+Philippines&rft.au=Lu%2C+Jinky+Leilanie&rft.aulast=Lu&rft.aufirst=Jinky&rft.date=2011-09-01&rft.volume=220&rft.issue=1-4&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Water%2C+Air%2C+%26+Soil+Pollution&rft.issn=00496979&rft_id=info:doi/10.1007%2Fs11270-011-0778-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Soil pollution; farms; Philippines DO - http://dx.doi.org/10.1007/s11270-011-0778-9 ER - TY - JOUR T1 - Randomized, Placebo-controlled Clinical Trial of an Aerosolized [Beta]^sub 2^-Agonist for Treatment of Acute Lung Injury AN - 887636215 JF - American Journal of Respiratory and Critical Care Medicine AU - Anonymous Y1 - 2011/09/01/ PY - 2011 DA - 2011 Sep 01 SP - 561 EP - 568 CY - New York PB - American Thoracic Society VL - 184 IS - 5 SN - 1073449X KW - Medical Sciences--Respiratory Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/887636215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Randomized%2C+Placebo-controlled+Clinical+Trial+of+an+Aerosolized+%5BBeta%5D%5Esub+2%5E-Agonist+for+Treatment+of+Acute+Lung+Injury&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-09-01&rft.volume=184&rft.issue=5&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Sep 1, 2011 N1 - Last updated - 2017-01-07 ER - TY - JOUR T1 - Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells. AN - 887505099; 21865652 AB - It has long been hypothesized that abnormalities in lipid biology contribute to degenerative brain diseases. Consistent with this, emerging epidemiologic evidence links lipid alterations with Parkinson disease (PD), and disruption of lipid metabolism has been found to predispose to α-synuclein toxicity. We therefore investigated whether Parkin, an E3 ubiquitin ligase found to be defective in patients with early onset PD, regulates systemic lipid metabolism. We perturbed lipid levels by exposing Parkin+/+ and Parkin-/- mice to a high-fat and -cholesterol diet (HFD). Parkin-/- mice resisted weight gain, steatohepatitis, and insulin resistance. In wild-type mice, the HFD markedly increased hepatic Parkin levels in parallel with lipid transport proteins, including CD36, Sr-B1, and FABP. These lipid transport proteins were not induced in Parkin-/- mice. The role of Parkin in fat uptake was confirmed by increased oleate accumulation in hepatocytes overexpressing Parkin and decreased uptake in Parkin-/- mouse embryonic fibroblasts and patient cells harboring complex heterozygous mutations in the Parkin-encoding gene PARK2. Parkin conferred this effect, in part, via ubiquitin-mediated stabilization of the lipid transporter CD36. Reconstitution of Parkin restored hepatic fat uptake and CD36 levels in Parkin-/- mice, and Parkin augmented fat accumulation during adipocyte differentiation. These results demonstrate that Parkin is regulated in a lipid-dependent manner and modulates systemic fat uptake via ubiquitin ligase-dependent effects. Whether this metabolic regulation contributes to premature Parkinsonism warrants investigation. JF - The Journal of clinical investigation AU - Kim, Kye-Young AU - Stevens, Mark V AU - Akter, M Hasina AU - Rusk, Sarah E AU - Huang, Robert J AU - Cohen, Alexandra AU - Noguchi, Audrey AU - Springer, Danielle AU - Bocharov, Alexander V AU - Eggerman, Tomas L AU - Suen, Der-Fen AU - Youle, Richard J AU - Amar, Marcelo AU - Remaley, Alan T AU - Sack, Michael N AD - Center for Molecular Medicine, NHLBI, 10 Center Drive, Bethesda, Maryland, 20892-1454, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 3701 EP - 3712 VL - 121 IS - 9 KW - Antigens, CD36 KW - 0 KW - Dietary Fats KW - Insulin KW - alpha-Synuclein KW - Ubiquitin-Protein Ligases KW - EC 2.3.2.27 KW - parkin protein KW - Glucose KW - IY9XDZ35W2 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Antigens, CD36 -- metabolism KW - alpha-Synuclein -- metabolism KW - Adipose Tissue -- cytology KW - Antigens, CD36 -- genetics KW - Glucose -- metabolism KW - Humans KW - Insulin -- blood KW - Parkinson Disease -- metabolism KW - Mice KW - Weight Gain KW - Energy Metabolism KW - Parkinson Disease -- genetics KW - Mice, Knockout KW - Eating KW - Adipose Tissue -- metabolism KW - Body Temperature KW - Mice, Inbred C57BL KW - Insulin Resistance KW - Male KW - Cell Line KW - Dietary Fats -- metabolism KW - Ubiquitin-Protein Ligases -- genetics KW - Ubiquitin-Protein Ligases -- metabolism KW - Lipid Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/887505099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Parkin+is+a+lipid-responsive+regulator+of+fat+uptake+in+mice+and+mutant+human+cells.&rft.au=Kim%2C+Kye-Young%3BStevens%2C+Mark+V%3BAkter%2C+M+Hasina%3BRusk%2C+Sarah+E%3BHuang%2C+Robert+J%3BCohen%2C+Alexandra%3BNoguchi%2C+Audrey%3BSpringer%2C+Danielle%3BBocharov%2C+Alexander+V%3BEggerman%2C+Tomas+L%3BSuen%2C+Der-Fen%3BYoule%2C+Richard+J%3BAmar%2C+Marcelo%3BRemaley%2C+Alan+T%3BSack%2C+Michael+N&rft.aulast=Kim&rft.aufirst=Kye-Young&rft.date=2011-09-01&rft.volume=121&rft.issue=9&rft.spage=3701&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=1558-8238&rft_id=info:doi/10.1172%2FJCI44736 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-31 N1 - Date created - 2011-09-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurochem. 2008 Jun;105(5):1806-19 [18248624] J Biol Chem. 2008 May 16;283(20):13578-85 [18353783] Mov Disord. 2008 May 15;23(7):1013-8 [18381649] Nat Genet. 2000 Jul;25(3):302-5 [10888878] J Clin Invest. 2002 May;109(10):1381-9 [12021254] Proc Natl Acad Sci U S A. 2003 May 13;100(10):5956-61 [12719539] Hum Mol Genet. 2003 Jun 15;12(12):1427-37 [12783850] Hum Mol Genet. 2003 Oct 15;12(20):2587-97 [12925569] J Biol Chem. 2003 Oct 31;278(44):43628-35 [12930822] Science. 2003 Dec 5;302(5651):1769-72 [14657499] Development. 2004 May;131(9):2183-94 [15073152] J Biol Chem. 2004 Apr 30;279(18):18614-22 [14985362] Mov Disord. 2004 Oct;19(10):1146-57 [15390068] Biochem J. 1988 Feb 15;250(1):203-7 [3355511] Neuroscience. 1998 Apr;83(3):791-8 [9483562] Nature. 1998 Apr 9;392(6676):605-8 [9560156] J Clin Invest. 2004 Nov;114(9):1326-33 [15520865] Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2174-9 [15684050] J Neurosci. 2005 Feb 23;25(8):2002-9 [15728840] J Clin Invest. 2005 Apr;115(4):1030-8 [15761499] Neurology. 2005 Jun 28;64(12):2040-5 [15985568] Anal Biochem. 2005 Aug 15;343(2):277-82 [15993372] J Neurosci. 2005 Aug 31;25(35):7968-78 [16135753] J Biol Chem. 2006 Feb 10;281(6):3204-9 [16339143] Hum Genet. 2008 Aug;124(1):63-71 [18560894] FASEB J. 2008 Sep;22(9):3135-45 [18495756] J Biol Chem. 2008 Oct 31;283(44):29650-7 [18728004] J Immunol. 2008 Nov 15;181(10):7147-56 [18981136] J Cell Biol. 2008 Dec 1;183(5):795-803 [19029340] J Clin Invest. 2009 Mar;119(3):650-60 [19229105] J Biol Chem. 2009 Mar 27;284(13):8209 [19008216] J Med Genet. 2009 Jun;46(6):375-81 [19351622] Autophagy. 2009 Jul;5(5):706-8 [19377297] Science. 2009 Jul 3;325(5936):100-4 [19520913] J Biol Chem. 2009 Aug 21;284(34):22938-51 [19546216] J Neurochem. 2009 Nov;111(3):696-702 [19694908] Nat Cell Biol. 2009 Nov;11(11):1370-5 [19801972] Mol Cell. 2009 Dec 25;36(6):1034-47 [20064468] Nat Cell Biol. 2010 Feb;12(2):119-31 [20098416] J Biol Chem. 2010 Apr 30;285(18):13580-8 [20189990] J Cell Biol. 2010 Dec 27;191(7):1367-80 [21173115] Hum Mol Genet. 2006 Jul 1;15(13):2059-75 [16714300] Nat Cell Biol. 2006 Aug;8(8):834-42 [16862145] J Physiol. 2006 Sep 1;575(Pt 2):373-7 [16840513] Am J Epidemiol. 2006 Nov 15;164(10):998-1002 [16905642] Diabetes. 2006 Dec;55(12):3411-7 [17130487] Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3095-100 [17360614] Comment In: J Clin Invest. 2011 Sep;121(9):3389-92 [21865651] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1172/JCI44736 ER - TY - JOUR T1 - The dgt gene of Escherichia coli facilitates thymine utilization in thymine-requiring strains. AN - 887502926; 21736641 AB - The Escherichia coli dGTP triphosphohydrolase (dGTPase) encoded by the dgt gene catalyses the hydrolysis of dGTP to deoxyguanosine and triphosphate. The recent discovery of a mutator effect associated with deletion of dgt indicated participation of the triphosphohydrolase in preventing mutagenesis. Here, we have investigated the possible involvement of dgt in facilitating thymine utilization through its ability to provide intracellular deoxyguanosine, which is readily converted by the DeoD phosphorylase to deoxyribose-1-phosphate, the critical intermediate that enables uptake and utilization of thymine. Indeed, we observed that the minimal amount of thymine required for growth of thymine-requiring (thyA) strains decreased with increased expression level of the dgt gene. As expected, this dgt-mediated effect was dependent on the DeoD purine nucleoside phosphorylase. We also observed that thyA strains experience growth difficulties upon nutritional shift-up and that the dgt gene facilitates adaptation to the new growth conditions. Blockage of the alternative yjjG (dUMP phosphatase) pathway for deoxyribose-1-phosphate generation greatly exacerbated the severity of thymine starvation in enriched media, and under these conditions the dgt pathway becomes crucial in protecting the cells against thymineless death. Overall, our results suggest that the dgt-dependent pathway for deoxyribose-1-phosphate generation may operate under various cell conditions to provide deoxyribosyl donors. © Published 2011. This article is a US Government work and is in the public domain in the USA. JF - Molecular microbiology AU - Itsko, Mark AU - Schaaper, Roel M AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 1221 EP - 1232 VL - 81 IS - 5 KW - Deoxyguanine Nucleotides KW - 0 KW - Escherichia coli Proteins KW - Deoxyribose KW - 533-67-5 KW - deoxyguanosine triphosphate KW - 8C2O37Y44Q KW - Purine-Nucleoside Phosphorylase KW - EC 2.4.2.1 KW - YjjG protein, E coli KW - EC 3.1.3.- KW - N-Glycosyl Hydrolases KW - EC 3.2.2.- KW - GTP Phosphohydrolases KW - EC 3.6.1.- KW - Deoxyguanosine KW - G9481N71RO KW - Thymine KW - QR26YLT7LT KW - Index Medicus KW - Purine-Nucleoside Phosphorylase -- metabolism KW - Deoxyguanosine -- metabolism KW - Deoxyguanine Nucleotides -- metabolism KW - Deoxyribose -- genetics KW - Deoxyribose -- metabolism KW - Sequence Deletion KW - Escherichia coli Proteins -- metabolism KW - Escherichia coli -- metabolism KW - Thymine -- metabolism KW - GTP Phosphohydrolases -- genetics KW - N-Glycosyl Hydrolases -- metabolism KW - GTP Phosphohydrolases -- metabolism KW - Escherichia coli -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/887502926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=The+dgt+gene+of+Escherichia+coli+facilitates+thymine+utilization+in+thymine-requiring+strains.&rft.au=Itsko%2C+Mark%3BSchaaper%2C+Roel+M&rft.aulast=Itsko&rft.aufirst=Mark&rft.date=2011-09-01&rft.volume=81&rft.issue=5&rft.spage=1221&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=1365-2958&rft_id=info:doi/10.1111%2Fj.1365-2958.2011.07756.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-02-21 N1 - Date created - 2011-09-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Microbiol. 2004 Mar;51(5):1279-95 [14982624] J Biochem. 2004 Aug;136(2):221-31 [15496593] Cold Spring Harb Symp Quant Biol. 1968;33:809-22 [4892010] Nature. 1970 Apr 11;226(5241):126-31 [4908371] Eur J Biochem. 1970 Jul;15(1):191-202 [4923156] J Bacteriol. 1971 Feb;105(2):657-65 [5541539] Mol Gen Genet. 1971;111(1):77-83 [4932244] J Mol Biol. 1971 Aug 28;60(1):75-86 [4937195] J Biol Chem. 1972 Nov 25;247(22):7116-22 [4565077] J Bacteriol. 1973 May;114(2):824-37 [4574701] Eur J Biochem. 1973 Dec 17;40(2):345-54 [4592648] Mol Gen Genet. 1978 Feb 16;159(2):191-202 [204861] Proc Natl Acad Sci U S A. 1983 Mar;80(6):1669-73 [6300866] J Biol Chem. 1987 Apr 15;262(11):5288-92 [3549718] J Biol Chem. 1988 Jan 25;263(3):1494-9 [2826481] Proc Natl Acad Sci U S A. 1988 Apr;85(8):2563-7 [2833745] Microbiol Rev. 1989 Mar;53(1):1-24 [2540407] Proc Natl Acad Sci U S A. 1990 Apr;87(7):2740-4 [2157212] Gene. 1990 Apr 30;89(1):13-8 [2165018] J Biol Chem. 1993 Sep 25;268(27):20046-54 [8397198] J Bacteriol. 1994 Apr;176(8):2194-9 [8157589] Mutat Res. 1994 Aug;318(1):1-64 [7519315] Mol Microbiol. 1995 Mar;15(5):789-94 [7596281] Pharmacol Ther. 1995;67(2):155-86 [7494863] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5 [10829079] J Mol Biol. 2000 Aug 25;301(4):827-37 [10966789] Prog Nucleic Acid Res Mol Biol. 1998;59:205-55 [9427844] Annu Rev Microbiol. 1998;52:591-625 [9891809] Biochim Biophys Acta. 1958 Nov;30(2):428-9 [13607463] J Gen Microbiol. 1958 Dec;19(3):607-16 [13611203] Biochim Biophys Acta. 1962 Nov 26;61:775-90 [14034805] J Biol Chem. 1956 Jan;218(1):97-106 [13278318] J Biol Chem. 2004 Dec 24;279(52):54687-94 [15489502] Mol Microbiol. 2006 Jan;59(1):5-19 [16359314] J Bacteriol. 2006 Mar;188(5):1667-79 [16484178] J Bacteriol. 2007 Mar;189(5):2186-9 [17189366] FEMS Microbiol Lett. 2007 May;270(1):49-57 [17286574] J Bacteriol. 2007 Nov;189(21):7922-6 [17827303] J Bacteriol. 2008 Nov;190(21):6931-9 [18776019] FEBS J. 2009 Jun;276(12):3211-21 [19438719] PLoS Genet. 2010 Mar;6(3):e1000865 [20221259] Mol Microbiol. 2010 Mar;75(6):1455-67 [20132444] Genes Cells. 2010 Jun;15(6):619-34 [20465561] ACS Chem Biol. 2010 Aug 20;5(8):787-95 [20553049] DNA Repair (Amst). 2011 Jan 2;10(1):94-101 [21074501] J Biol Chem. 2001 Feb 23;276(8):5518-24 [11078735] Nucleic Acids Res. 2003 Jan 15;31(2):517-31 [12527759] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2958.2011.07756.x ER - TY - JOUR T1 - Estimating water supply arsenic levels in the New England Bladder Cancer Study. AN - 887501970; 21421449 AB - Ingestion of inorganic arsenic in drinking water is recognized as a cause of bladder cancer when levels are relatively high (≥ 150 µg/L). The epidemiologic evidence is less clear at the low-to-moderate concentrations typically observed in the United States. Accurate retrospective exposure assessment over a long time period is a major challenge in conducting epidemiologic studies of environmental factors and diseases with long latency, such as cancer. We estimated arsenic concentrations in the water supplies of 2,611 participants in a population-based case-control study in northern New England. Estimates covered the lifetimes of most study participants and were based on a combination of arsenic measurements at the homes of the participants and statistical modeling of arsenic concentrations in the water supply of both past and current homes. We assigned a residential water supply arsenic concentration for 165,138 (95%) of the total 173,361 lifetime exposure years (EYs) and a workplace water supply arsenic level for 85,195 EYs (86% of reported occupational years). Three methods accounted for 93% of the residential estimates of arsenic concentration: direct measurement of water samples (27%; median, 0.3 µg/L; range, 0.1-11.5), statistical models of water utility measurement data (49%; median, 0.4 µg/L; range, 0.3-3.3), and statistical models of arsenic concentrations in wells using aquifers in New England (17%; median, 1.6 µg/L; range, 0.6-22.4). We used a different validation procedure for each of the three methods, and found our estimated levels to be comparable with available measured concentrations. This methodology allowed us to calculate potential drinking water exposure over long periods. JF - Environmental health perspectives AU - Nuckols, John R AU - Freeman, Laura E Beane AU - Lubin, Jay H AU - Airola, Matthew S AU - Baris, Dalsu AU - Ayotte, Joseph D AU - Taylor, Anne AU - Paulu, Chris AU - Karagas, Margaret R AU - Colt, Joanne AU - Ward, Mary H AU - Huang, An-Tsun AU - Bress, William AU - Cherala, Sai AU - Silverman, Debra T AU - Cantor, Kenneth P AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. jnuckols@colostate.edu Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 1279 EP - 1285 VL - 119 IS - 9 KW - Drinking Water KW - 0 KW - Water Pollutants, Chemical KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Maine -- epidemiology KW - Young Adult KW - Regression Analysis KW - New Hampshire -- epidemiology KW - Humans KW - Vermont -- epidemiology KW - Retrospective Studies KW - Infant, Newborn KW - Aged KW - Child KW - Risk Assessment KW - Infant KW - Adult KW - Case-Control Studies KW - Environmental Exposure KW - Middle Aged KW - Epidemiological Monitoring KW - Adolescent KW - Male KW - Female KW - Arsenic -- analysis KW - Water Pollutants, Chemical -- analysis KW - Urinary Bladder Neoplasms -- epidemiology KW - Drinking Water -- chemistry KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/887501970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Estimating+water+supply+arsenic+levels+in+the+New+England+Bladder+Cancer+Study.&rft.au=Nuckols%2C+John+R%3BFreeman%2C+Laura+E+Beane%3BLubin%2C+Jay+H%3BAirola%2C+Matthew+S%3BBaris%2C+Dalsu%3BAyotte%2C+Joseph+D%3BTaylor%2C+Anne%3BPaulu%2C+Chris%3BKaragas%2C+Margaret+R%3BColt%2C+Joanne%3BWard%2C+Mary+H%3BHuang%2C+An-Tsun%3BBress%2C+William%3BCherala%2C+Sai%3BSilverman%2C+Debra+T%3BCantor%2C+Kenneth+P&rft.aulast=Nuckols&rft.aufirst=John&rft.date=2011-09-01&rft.volume=119&rft.issue=9&rft.spage=1279&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1002345 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-13 N1 - Date created - 2011-09-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Sci Technol. 2003 May 15;37(10):2075-83 [12785510] Int J Occup Med Environ Health. 2001;14(2):171-5 [11548067] Am J Epidemiol. 2004 Feb 15;159(4):381-9 [14769642] Environ Health Perspect. 2004 Jun;112(9):1007-15 [15198921] Cancer Causes Control. 2004 Jun;15(5):465-72 [15286466] Am J Epidemiol. 1995 Mar 15;141(6):523-30 [7900719] Environ Health Perspect. 1998 Aug;106 Suppl 4:1047-50 [9703491] Environ Health Perspect. 1999 Sep;107(9):705-10 [10464069] Environ Health Perspect. 2004 Dec;112(17):1691-6 [15579415] IARC Monogr Eval Carcinog Risks Hum. 2004;84:269-477 [15645578] Environ Sci Technol. 2006 Jun 1;40(11):3578-85 [16786697] Int Arch Occup Environ Health. 2007 Jan;80(3):184-97 [16897097] J Natl Cancer Inst. 2007 Jun 20;99(12):920-8 [17565158] Toxicol Appl Pharmacol. 2007 Aug 1;222(3):252-7 [17382983] Environ Health Perspect. 2008 Feb;116(2):231-7 [18288323] Occup Environ Med. 2008 Jun;65(6):420-9 [18032532] Regul Toxicol Pharmacol. 2008 Dec;52(3):299-310 [18783726] Lancet Oncol. 2009 May;10(5):453-4 [19418618] J Natl Cancer Inst. 2009 Nov 18;101(22):1553-61 [19917915] J Expo Sci Environ Epidemiol. 2010 May;20(3):245-54 [19401722] Am J Epidemiol. 2003 Dec 15;158(12):1193-201 [14652304] Erratum In: Environ Health Perspect. 2011 Dec;119(12):A509 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.1002345 ER - TY - JOUR T1 - Cytotoxic activity of immunotoxin SS1P is modulated by TACE-dependent mesothelin shedding. AN - 887501489; 21775520 AB - Mesothelin is a cell-surface tumor-associated antigen expressed in several human cancers. The limited expression of mesothelin on normal tissues and its high expression in many cancers make it an attractive candidate for targeted therapies using monoclonal antibodies, immunoconjugates, and immunotoxins. Mesothelin is actively shed from the cell surface and is present in the serum of patients with malignant mesothelioma, which could negatively affect the response to these therapies. We have found that mesothelin sheddase activity is mediated by a TNF-α converting enzyme (TACE), a member of the matrix metalloproteinase/a disintegrin and metalloprotease family. We showed that EGF and TIMP-3 act through TACE as endogenous regulators of mesothelin shedding. We also found that reducing shedding significantly improved the in vitro cytotoxicity of immunotoxin SS1P, which targets mesothelin and is currently in clinical trials for the treatment of patients with mesothelioma and lung cancer. Our findings provide a mechanistic understanding of mesothelin shedding and could help improve mesothelin-based targeted therapies. ©2011 AACR. JF - Cancer research AU - Zhang, Yujian AU - Chertov, Oleg AU - Zhang, Jingli AU - Hassan, Raffit AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA. Y1 - 2011/09/01/ PY - 2011 DA - 2011 Sep 01 SP - 5915 EP - 5922 VL - 71 IS - 17 KW - Antibodies, Monoclonal KW - 0 KW - Cytotoxins KW - GPI-Linked Proteins KW - SS1(dsFv)PE38 KW - Tissue Inhibitor of Metalloproteinase-3 KW - mesothelin KW - Epidermal Growth Factor KW - 62229-50-9 KW - ADAM Proteins KW - EC 3.4.24.- KW - ADAM17 Protein KW - EC 3.4.24.86 KW - ADAM17 protein, human KW - Index Medicus KW - Tissue Inhibitor of Metalloproteinase-3 -- metabolism KW - Mesothelioma -- metabolism KW - Humans KW - Cell Line, Tumor KW - Epidermal Growth Factor -- metabolism KW - ADAM Proteins -- metabolism KW - GPI-Linked Proteins -- metabolism KW - Cytotoxins -- pharmacology KW - Antibodies, Monoclonal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/887501489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Cytotoxic+activity+of+immunotoxin+SS1P+is+modulated+by+TACE-dependent+mesothelin+shedding.&rft.au=Zhang%2C+Yujian%3BChertov%2C+Oleg%3BZhang%2C+Jingli%3BHassan%2C+Raffit%3BPastan%2C+Ira&rft.aulast=Zhang&rft.aufirst=Yujian&rft.date=2011-09-01&rft.volume=71&rft.issue=17&rft.spage=5915&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-11-0466 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-25 N1 - Date created - 2011-09-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2007 Mar 16;282(11):8325-31 [17227756] Exp Cell Res. 2006 Dec 10;312(20):3969-80 [17010968] Curr Pharm Des. 2007;13(20):2087-100 [17627541] Clin Cancer Res. 2007 Sep 1;13(17):5144-9 [17785569] Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17099-104 [17940013] Clin Cancer Res. 2007 Dec 1;13(23):7166-71 [18056197] Cancer Sci. 2008 Mar;99(3):590-4 [18167128] FASEB J. 2008 Oct;22(10):3515-24 [18632849] Biol Chem. 2008 Aug;389(8):1075-84 [18979631] Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3360-5 [19211796] Curr Pharm Des. 2009;15(20):2319-35 [19601834] Clin Cancer Res. 2009 Aug 15;15(16):5274-9 [19671873] Cancer Res. 2010 Jan 1;70(1):109-18 [20028856] Cancer Res. 2010 Feb 1;70(3):1082-9 [20103626] Biochim Biophys Acta. 2010 Jan;1803(1):55-71 [20080133] Clin Transl Sci. 2008 Dec;1(3):228-39 [20357913] Cancer Res. 2010 Nov 15;70(22):9053-61 [20926399] Clin Cancer Res. 2010 Dec 15;16(24):6132-8 [21037025] J Biol Chem. 2001 Oct 12;276(41):37743-6 [11477090] Cell Mol Life Sci. 2001 Dec;58(14):1969-87 [11814051] EMBO J. 2003 Mar 3;22(5):1114-24 [12606576] Mod Pathol. 2003 Mar;16(3):192-7 [12640097] Am J Surg Pathol. 2003 Nov;27(11):1418-28 [14576474] Lancet. 2003 Nov 15;362(9396):1612-6 [14630441] J Immunol. 2004 Apr 1;172(7):4324-31 [15034047] Int J Cancer. 1994 Apr 1;57(1):90-7 [8150545] Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):136-40 [8552591] Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11531-6 [10500211] Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):1014-20 [16702385] Cancer Cell. 2006 Jul;10(1):39-50 [16843264] Clin Cancer Res. 2006 Aug 1;12(15):4695-701 [16899620] Biochem Biophys Res Commun. 2006 Nov 24;350(3):629-33 [17027649] Gene Ther. 2007 Jun;14(12):921-9 [17377599] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-11-0466 ER - TY - JOUR T1 - Mi-2/NuRD complex function is required for normal S phase progression and assembly of pericentric heterochromatin. AN - 886917840; 21737684 AB - During chromosome duplication, it is essential to replicate not only the DNA sequence, but also the complex nucleoprotein structures of chromatin. Pericentric heterochromatin is critical for silencing repetitive elements and plays an essential structural role during mitosis. However, relatively little is understood about its assembly and maintenance during replication. The Mi2/NuRD chromatin remodeling complex tightly associates with actively replicating pericentric heterochromatin, suggesting a role in its assembly. Here we demonstrate that depletion of the catalytic ATPase subunit CHD4/Mi-2β in cells with a dampened DNA damage response results in a slow-growth phenotype characterized by delayed progression through S phase. Furthermore, we observe defects in pericentric heterochromatin maintenance and assembly. Our data suggest that chromatin assembly defects are sensed by an ATM-dependent intra-S phase chromatin quality checkpoint, resulting in a temporal block to the transition from early to late S phase. These findings implicate Mi-2β in the maintenance of chromatin structure and proper cell cycle progression. JF - Molecular biology of the cell AU - Sims, Jennifer K AU - Wade, Paul A AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 3094 EP - 3102 VL - 22 IS - 17 KW - Autoantigens KW - 0 KW - CHD4 protein, human KW - Cell Cycle Proteins KW - DNA-Binding Proteins KW - Heterochromatin KW - Histones KW - Tumor Suppressor Proteins KW - ATM protein, human KW - EC 2.7.11.1 KW - Ataxia Telangiectasia Mutated Proteins KW - Protein-Serine-Threonine Kinases KW - Mi-2 Nucleosome Remodeling and Deacetylase Complex KW - EC 3.5.1.98 KW - Index Medicus KW - Protein-Serine-Threonine Kinases -- metabolism KW - Humans KW - Autoantigens -- genetics KW - Cell Proliferation KW - S Phase Cell Cycle Checkpoints KW - Cell Cycle Proteins -- metabolism KW - Microscopy, Fluorescence KW - Gene Knockdown Techniques KW - Phosphorylation KW - Histones -- metabolism KW - Tumor Suppressor Proteins -- metabolism KW - RNA Interference KW - Autoantigens -- metabolism KW - Cell Line KW - DNA-Binding Proteins -- metabolism KW - Mi-2 Nucleosome Remodeling and Deacetylase Complex -- metabolism KW - Mi-2 Nucleosome Remodeling and Deacetylase Complex -- genetics KW - Heterochromatin -- metabolism KW - S Phase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/886917840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+biology+of+the+cell&rft.atitle=Mi-2%2FNuRD+complex+function+is+required+for+normal+S+phase+progression+and+assembly+of+pericentric+heterochromatin.&rft.au=Sims%2C+Jennifer+K%3BWade%2C+Paul+A&rft.aulast=Sims&rft.aufirst=Jennifer&rft.date=2011-09-01&rft.volume=22&rft.issue=17&rft.spage=3094&rft.isbn=&rft.btitle=&rft.title=Molecular+biology+of+the+cell&rft.issn=1939-4586&rft_id=info:doi/10.1091%2Fmbc.E11-03-0258 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-30 N1 - Date created - 2011-08-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2003 Jan 30;421(6922):499-506 [12556884] Nat Genet. 2002 Dec;32(4):627-32 [12434153] EMBO J. 2003 Apr 1;22(7):1676-87 [12660173] Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10635-40 [12953102] EMBO J. 2003 Oct 1;22(19):5154-62 [14517253] Mol Cell. 2003 Dec;12(6):1591-8 [14690610] Cell. 2004 Oct 1;119(1):75-86 [15454082] Curr Biol. 1998 Jul 2;8(14):843-6 [9663395] Nat Cell Biol. 2004 Dec;6(12):1236-44 [15543136] Mol Biol Cell. 2005 Jun;16(6):2872-81 [15788566] Biochimie. 2005 Jul;87(7):591-602 [15989976] Nat Cell Biol. 2006 Aug;8(8):870-6 [16862143] Cell. 2007 Feb 23;128(4):721-33 [17320509] Development. 2007 Mar;134(6):1123-32 [17287250] Curr Opin Cell Biol. 2007 Jun;19(3):273-80 [17466503] Mol Biol Cell. 2007 Sep;18(9):3667-80 [17626165] Science. 2007 Dec 21;318(5858):1928-31 [18096807] Nat Chem Biol. 2008 Feb;4(2):119-25 [18176557] Mol Cell. 2008 Apr 11;30(1):61-72 [18406327] Nat Struct Mol Biol. 2008 Sep;15(9):972-9 [19172751] Chromosoma. 2009 Aug;118(4):445-57 [19296121] Mol Biol Cell. 2009 Jul;20(14):3192-9 [19458193] Nat Cell Biol. 2009 Oct;11(10):1261-7 [19734887] Mol Cell. 2010 Mar 12;37(5):736-43 [20227376] J Cell Physiol. 2010 Jun;223(3):667-78 [20333683] Biochim Biophys Acta. 2000 Feb 14;1470(1):O1-8 [10656988] Mol Cell. 2001 Jan;7(1):13-20 [11172707] Nature. 2001 Mar 1;410(6824):116-20 [11242053] Nature. 2001 Mar 1;410(6824):120-4 [11242054] Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000794 [20591991] J Exp Med. 2010 Aug 30;207(9):1939-50 [20733034] J Cell Biol. 2010 Sep 6;190(5):741-9 [20805320] J Cell Biol. 2010 Sep 6;190(5):731-40 [20805324] EMBO J. 2010 Sep 15;29(18):3130-9 [20693977] Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18475-80 [20937877] Nucleic Acids Res. 2010 Nov;38(20):6906-19 [20571081] Genes Dev. 2001 May 1;15(9):1061-6 [11331602] Mol Cell. 2001 Apr;7(4):729-39 [11336697] Science. 2002 Sep 13;297(5588):1871-3 [12077425] Mol Cell. 2003 Feb;11(2):341-51 [12620223] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1091/mbc.E11-03-0258 ER - TY - JOUR T1 - Assessment of the safety and biodistribution of a regulated AAV2 gene transfer vector after delivery to murine submandibular glands. AN - 886917413; 21625005 AB - Clinical gene transfer holds promise for the treatment of many inherited and acquired disorders. A key consideration for all clinical gene transfer applications is the tight control of transgene expression. We have examined the safety and biodistribution of a serotype 2, recombinant adeno-associated viral (AAV2) vector that encodes a rapamycin-responsive chimeric transcription factor, which regulates the expression of a therapeutic transgene (human erythropoietin [hEpo]). The vector, AAV2-TF2.3w-hEpo (2.5 × 10(7)-2.5 × 10(10) particles), was administered once to a single submandibular gland of male and female mice and mediated hEpo expression in vivo following a rapamycin injection but not in its absence. Control (saline treated) and vector-treated animals maintained their weight, and consumed food and water, similarly. Vector delivery led to no significant toxicological effects as judged by hematology, clinical chemistry, and gross and microscopic pathology evaluations. On day 3 after vector delivery, vector copies were not only abundant in the targeted right submandibular gland but also detected in multiple other tissues. Vector was cleared from the targeted gland much more rapidly in female mice than in male mice. Overall, our results are consistent with the notion that administration of the AAV2-TF2.3w-hEpo vector to salivary glands posed no significant risk in mice. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Zheng, Changyu AU - Voutetakis, Antonis AU - Goldstein, Benjamin AU - Afione, Sandra AU - Rivera, Victor M AU - Clackson, Tim AU - Wenk, Martin L AU - Boyle, Molly AU - Nyska, Abraham AU - Chiorini, John A AU - Vallant, Molly AU - Irwin, Richard D AU - Baum, Bruce J AD - Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, 20892, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 247 EP - 255 VL - 123 IS - 1 KW - Erythropoietin KW - 11096-26-7 KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Body Weight KW - Animals KW - Erythropoietin -- blood KW - Sex Factors KW - Sirolimus -- pharmacology KW - Toxicity Tests KW - Erythropoietin -- genetics KW - Mice KW - Mice, Inbred BALB C KW - Male KW - Female KW - Risk Assessment KW - Genetic Vectors -- administration & dosage KW - Submandibular Gland -- virology KW - Submandibular Gland -- metabolism KW - Gene Transfer Techniques -- adverse effects KW - Dependovirus -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/886917413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Assessment+of+the+safety+and+biodistribution+of+a+regulated+AAV2+gene+transfer+vector+after+delivery+to+murine+submandibular+glands.&rft.au=Zheng%2C+Changyu%3BVoutetakis%2C+Antonis%3BGoldstein%2C+Benjamin%3BAfione%2C+Sandra%3BRivera%2C+Victor+M%3BClackson%2C+Tim%3BWenk%2C+Martin+L%3BBoyle%2C+Molly%3BNyska%2C+Abraham%3BChiorini%2C+John+A%3BVallant%2C+Molly%3BIrwin%2C+Richard+D%3BBaum%2C+Bruce+J&rft.aulast=Zheng&rft.aufirst=Changyu&rft.date=2011-09-01&rft.volume=123&rft.issue=1&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfr144 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-20 N1 - Date created - 2011-08-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hum Gene Ther. 1999 Nov 20;10(17):2789-97 [10584925] Methods Mol Biol. 2010;666:3-20 [20717774] Nat Genet. 2000 Mar;24(3):257-61 [10700178] J Virol. 2000 Oct;74(20):9451-63 [11000214] Int Rev Cytol. 2002;213:93-146 [11837896] Blood. 2002 Apr 15;99(8):2670-6 [11929752] J Clin Invest. 2002 Aug;110(4):499-504 [12189244] J Clin Microbiol. 2003 Nov;41(11):5046-52 [14605137] Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3053-8 [14978265] Gene Ther. 2004 Apr;11(8):729-33 [14737095] Gene Ther. 2004 Oct;11(19):1425-6 [15269715] Nature. 1991 Jan 24;349(6307):351-2 [1987492] Am J Physiol. 1994 Jun;266(6 Pt 1):G1146-55 [8023944] Nat Med. 1996 Sep;2(9):1028-32 [8782462] Hum Gene Ther. 1996 Nov 10;7(17):2101-12 [8934224] Hum Gene Ther. 1996 Nov 10;7(17):2177-84 [8934231] Hum Gene Ther. 1998 Dec 10;9(18):2745-60 [9874273] Am J Physiol. 1999 Feb;276(2 Pt 1):E223-32 [9950780] J Virol. 1999 Mar;73(3):1949-55 [9971774] Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8657-62 [10411931] Trends Mol Med. 2004 Dec;10(12):585-90 [15567328] Blood. 2005 Feb 15;105(4):1424-30 [15507527] J Gene Med. 2005 Apr;7(4):432-41 [15515118] J Endocrinol. 2005 Jun;185(3):363-72 [15930162] Gene Ther. 2006 Jan;13(2):187-90 [16177817] Nat Med. 2006 Mar;12(3):342-7 [16474400] Gene Ther. 2006 Apr;13(7):594-601 [16341060] Hum Gene Ther. 2007 Feb;18(2):142-50 [17328682] Hum Gene Ther. 2007 Nov;18(11):1109-18 [17939749] Mol Ther. 2008 Jun;16(6):1089-97 [18388914] J Gene Med. 2009 Jun;11(6):506-14 [19326368] Hum Gene Ther. 2008 Dec;19(12):1401-5 [18764738] J Gene Med. 2010 Jan;12(1):3-10 [19941317] Mol Ther. 2010 Jan;18(1):80-6 [19904234] Gene Ther. 2010 Jan;17(1):50-60 [19759566] Oral Oncol. 2010 Jan;46(1):4-8 [19892587] J Virol. 2000 Mar;74(5):2420-5 [10666273] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfr144 ER - TY - JOUR T1 - Styrene exposure and risk of cancer. AN - 885563199; 21724974 AB - Styrene is widely used in the manufacture of synthetic rubber, resins, polyesters and plastics. Styrene and the primary metabolite styrene-7,8-oxide are genotoxic and carcinogenic. Long-term chemical carcinogenesis bioassays showed that styrene caused lung cancers in several strains of mice and mammary cancers in rats and styrene-7,8-oxide caused tumours of the forestomach in rats and mice and of the liver in mice. Subsequent epidemiologic studies found styrene workers had increased mortality or incidences of lymphohematopoietic cancers (leukaemia or lymphoma or all), with suggestive evidence for pancreatic and esophageal tumours. No adequate human studies are available for styrene-7,8-oxide although this is the primary and active epoxide metabolite of styrene. Both are genotoxic and form DNA adducts in humans. JF - Mutagenesis AU - Huff, James AU - Infante, Peter F AD - National Institute of Environmental Health Sciences, Research Triangle Park, 111 T.W.Alexander Drive, NC 27709, USA. huff1@niehs.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 583 EP - 584 VL - 26 IS - 5 KW - Styrene KW - 44LJ2U959V KW - Index Medicus KW - Humans KW - Male KW - Female KW - Cytogenetic Analysis -- methods KW - DNA Damage KW - Styrene -- toxicity KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885563199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Styrene+exposure+and+risk+of+cancer.&rft.au=Huff%2C+James%3BInfante%2C+Peter+F&rft.aulast=Huff&rft.aufirst=James&rft.date=2011-09-01&rft.volume=26&rft.issue=5&rft.spage=583&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fger033 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-20 N1 - Date created - 2011-08-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann N Y Acad Sci. 1999;895:56-79 [10676409] FASEB J. 2001 Jan;15(1):195-203 [11149907] Ann N Y Acad Sci. 2002 Dec;982:177-89 [12562636] Ann N Y Acad Sci. 2002 Dec;982:208-30 [12562639] IARC Monogr Eval Carcinog Risks Hum. 2002;82:1-556 [12687954] Annu Rev Pharmacol Toxicol. 1979;19:511-30 [378109] Prog Clin Biol Res. 1984;141:227-38 [6718375] Jpn J Cancer Res. 1989 Sep;80(9):795-807 [2513295] Lancet. 1991 Mar 2;337(8740):538-40 [1671901] Environ Health Perspect. 1993 Apr;100:201-10 [8354167] Environ Health Perspect. 1999 Jul;107(7):A341-2 [10405250] Occup Environ Med. 2006 Mar;63(3):157-8 [16497855] Ann Ist Super Sanita. 2006;42(2):113-7 [17033130] Ann N Y Acad Sci. 2006 Sep;1076:1-14 [17119190] Drug Metab Rev. 2006;38(4):805-53 [17145703] J Occup Environ Med. 2009 Nov;51(11):1275-87 [19858749] Occup Environ Med. 2010 May;67(5):341-7 [20447988] Med Lav. 2010 May-Jun;101(3):189-98 [20812660] Occup Environ Med. 2010 Oct;67(10):720 [20837652] Mutagenesis. 2010 Nov;25(6):617-21 [20729469] Environ Health. 2011;10 Suppl 1:S14 [21489210] Science. 2011 May 20;332(6032):916-7 [21596974] Med Lav. 2011 Jul-Aug;102(4):382-3; author reply 383 [21834276] Comment On: Mutagenesis. 2010 Nov;25(6):617-21 [20729469] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/mutage/ger033 ER - TY - JOUR T1 - The resveratrol analogue, 2,3',4,5'-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo[a]pyrene-DNA adduct formation in MCF-7 cells exposed to benzo[a]pyrene. AN - 885563185; 21669939 AB - Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) induces cytochrome P450 (CYP) 1A1 and 1B1 enzymes, which biotransform PAHs resulting in the formation of DNA adducts. We hypothesised that 2,3',4,5'-tetramethoxystilbene (TMS), an analogue of resveratrol and a potent CYP1B1 inhibitor, may inhibit r7, t8, t9-trihydroxy-c-10-(N(2)deoxyguanosyl)-7,8,9,10-tetrahydro-benzo[a]pyrene (BPdG) adduct formation in cells exposed to benzo[a]pyrene (BP). To address this, MCF-7 cells were cultured for 96 h in the presence of 1 μM BP, 1 μM BP + 1 μM TMS or 1 μM BP + 4 μM TMS. Cells were assayed at 2-12 h intervals for: BPdG adducts by r7, t8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE)-DNA chemiluminescence immunoassay; CYP1A1 and 1B1 gene expression changes by relative real-time polymerase chain reaction; and CYP1A1/1B1 enzyme activity by ethoxyresorufin-O-deethylase (EROD) assay. Whereas maximal BPdG levels were similar for all exposure groups, the times at which the maxima were reached increased by 16 and 24 h with the addition of 1 and 4 μM TMS, respectively. The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 μM BP, 1 μM BP + 1 μM TMS or 1 μM BP + 4 μM TMS, respectively. The area under the curve from 4 to 96 h of exposure (AUC(4-)(96 h)) for BPdG adduct formation was not increased in the presence of TMS, but for CYP1A1 and CYP1B1 expression fold increase AUC(4-)(96 h) and EROD-specific activity AUC(4-)(96 h), there were significant (P < 0.05) increases in the presence of 4 μM TMS. Therefore, during 96 h of exposure in MCF-7 cells, the combination of BP plus TMS caused a slowing of BP biotransformation, with an increase in CYP1A1 and CYP1B1 expression and EROD activity, and a slowing, but no change in magnitude of BPdG formation. JF - Mutagenesis AU - Einem Lindeman, Tracey AU - Poirier, Miriam C AU - Divi, Rao L AD - Carcinogen-DNA Interactions Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892-4255, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 629 EP - 635 VL - 26 IS - 5 KW - 2,4,3',5'-tetramethoxystilbene KW - 0 KW - DNA Adducts KW - Stilbenes KW - benzo(a)pyrene-DNA adduct KW - Benzo(a)pyrene KW - 3417WMA06D KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP1B1 protein, human KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP1B1 KW - Index Medicus KW - Cell Survival -- drug effects KW - Biotransformation KW - Humans KW - Up-Regulation -- drug effects KW - Enzyme Activation -- drug effects KW - Up-Regulation -- genetics KW - Cell Line, Tumor KW - Benzo(a)pyrene -- pharmacology KW - Cytochrome P-450 CYP1A1 -- genetics KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Stilbenes -- pharmacology KW - Cytochrome P-450 CYP1A1 -- analysis KW - Aryl Hydrocarbon Hydroxylases -- antagonists & inhibitors KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Gene Expression Regulation, Neoplastic -- drug effects KW - DNA Adducts -- metabolism KW - Benzo(a)pyrene -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885563185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=The+resveratrol+analogue%2C+2%2C3%27%2C4%2C5%27-tetramethoxystilbene%2C+does+not+inhibit+CYP+gene+expression%2C+enzyme+activity+and+benzo%5Ba%5Dpyrene-DNA+adduct+formation+in+MCF-7+cells+exposed+to+benzo%5Ba%5Dpyrene.&rft.au=Einem+Lindeman%2C+Tracey%3BPoirier%2C+Miriam+C%3BDivi%2C+Rao+L&rft.aulast=Einem+Lindeman&rft.aufirst=Tracey&rft.date=2011-09-01&rft.volume=26&rft.issue=5&rft.spage=629&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fger024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-20 N1 - Date created - 2011-08-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2000 Feb 15;60(4):908-15 [10706104] IARC Monogr Eval Carcinog Risks Hum. 2010;92:1-853 [21141735] Cell Mol Life Sci. 2002 Apr;59(4):665-81 [12022473] Carcinogenesis. 2002 Dec;23(12):2043-9 [12507927] Mutat Res. 2003 Jan;543(1):17-30 [12510015] Med Res Rev. 2003 Nov;23(6):657-68 [12939788] Cancer Sci. 2004 Jan;95(1):1-6 [14720319] Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):500-9 [14751521] Carcinogenesis. 2004 Oct;25(10):2005-13 [15142886] Science. 1976 Aug 13;193(4253):592-5 [959820] Nature. 1983 Jun 9-15;303(5917):468-72 [6304528] Mol Cell Biol. 1986 May;6(5):1471-7 [3785172] Carcinogenesis. 1990 Jul;11(7):1241-3 [2372884] Cancer Epidemiol Biomarkers Prev. 1993 Jul-Aug;2(4):341-7 [8348057] Ann N Y Acad Sci. 1993 Jun 23;685:624-40 [8395783] Cancer Res. 1995 Mar 1;55(5):1039-44 [7866986] Annu Rev Pharmacol Toxicol. 1995;35:307-40 [7598497] J Biol Chem. 1995 Aug 4;270(31):18175-8 [7629130] Cancer Epidemiol Biomarkers Prev. 1995 Jun;4(4):341-6 [7655328] Cancer Res. 1996 Jul 1;56(13):2979-84 [8674051] Cancer Res. 1997 Jul 15;57(14):3026-31 [9230218] Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10937-42 [9380738] Eur J Cancer. 1998 Apr;34(5):757-8 [9713287] Drug Metab Rev. 1999 May;31(2):437-47 [10335446] Chem Res Toxicol. 1999 Jul;12(7):623-9 [10409402] Mol Pharmacol. 1999 Oct;56(4):784-90 [10496962] Ann N Y Acad Sci. 2004 Dec;1028:247-57 [15650250] Drug Metab Dispos. 2005 Dec;33(12):1771-6 [16120791] Future Oncol. 2005 Apr;1(2):259-63 [16555997] Chem Res Toxicol. 2007 Mar;20(3):424-31 [17295519] Bioorg Med Chem. 2007 Aug 1;15(15):5047-60 [17544277] Cancer Res. 2007 Jun 15;67(12):5717-26 [17575138] Carcinogenesis. 2007 Jul;28(7):1426-9 [17277232] J Biochem Mol Toxicol. 2007;21(3):101-9 [17623886] J Steroid Biochem Mol Biol. 2007 Jun-Jul;105(1-5):150-8 [17582757] Mutagenesis. 2008 Jan;23(1):1-18 [17989146] Cancer Prev Res (Phila). 2008 Jul;1(2):135-45 [19138946] Future Oncol. 2010 Jan;6(1):75-91 [20021210] Cancer Res. 2001 Nov 15;61(22):8164-70 [11719446] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/mutage/ger024 ER - TY - JOUR T1 - Transformation frequency of a mariner-based transposon in Rickettsia rickettsii. AN - 885562668; 21764933 AB - Transformation frequencies of a mariner-based transposon system in Rickettsia rickettsii were determined using a plaque assay system for enumeration and isolation of mutants. Sequence analysis of insertion sites in both R. rickettsii and R. prowazekii indicated that insertions were random. Transposon mutagenesis provides a useful tool for rickettsial research. Copyright © 2011, American Society for Microbiology. All Rights Reserved. JF - Journal of bacteriology AU - Clark, Tina R AU - Lackey, Amanda M AU - Kleba, Betsy AU - Driskell, Lonnie O AU - Lutter, Erika I AU - Martens, Craig AU - Wood, David O AU - Hackstadt, Ted AD - Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 598401, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 4993 EP - 4995 VL - 193 IS - 18 KW - DNA Transposable Elements KW - 0 KW - DNA, Bacterial KW - Index Medicus KW - Viral Plaque Assay KW - DNA, Bacterial -- genetics KW - Mutagenesis, Insertional KW - Rickettsia prowazekii -- genetics KW - Rickettsia rickettsii -- genetics KW - Transformation, Genetic KW - DNA Transposable Elements -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885562668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Transformation+frequency+of+a+mariner-based+transposon+in+Rickettsia+rickettsii.&rft.au=Clark%2C+Tina+R%3BLackey%2C+Amanda+M%3BKleba%2C+Betsy%3BDriskell%2C+Lonnie+O%3BLutter%2C+Erika+I%3BMartens%2C+Craig%3BWood%2C+David+O%3BHackstadt%2C+Ted&rft.aulast=Clark&rft.aufirst=Tina&rft.date=2011-09-01&rft.volume=193&rft.issue=18&rft.spage=4993&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=1098-5530&rft_id=info:doi/10.1128%2FJB.05279-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-27 N1 - Date created - 2011-08-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Bacteriol. 2000 Jun;182(11):3289-91 [10809714] Infect Immun. 2011 Apr;79(4):1631-7 [21300770] Appl Environ Microbiol. 2004 May;70(5):2816-22 [15128537] J Bacteriol. 1969 Sep;99(3):910-2 [4984178] Appl Microbiol. 1974 Jun;27(6):1157-61 [4208640] Infect Immun. 1975 Jun;11(6):1391-404 [806528] Appl Microbiol. 1975 Sep;30(3):456-63 [810089] Infect Immun. 1976 Oct;14(4):1052-64 [825463] Annu Rev Microbiol. 1982;36:345-70 [6756292] Annu Rev Microbiol. 1986;40:287-309 [3096192] J Clin Microbiol. 1987 Jan;25(1):167-71 [2432081] FEMS Microbiol Lett. 1991 Jul 1;65(3):341-4 [1916232] Res Microbiol. 1992 Nov-Dec;143(9):821-9 [1299836] Infect Immun. 1993 May;61(5):1926-35 [8478082] Infect Agents Dis. 1996 Jun;5(3):127-43 [8805076] J Clin Microbiol. 1996 Aug;34(8):1944-8 [8818887] Emerg Infect Dis. 1998 Apr-Jun;4(2):179-86 [9621188] Clin Microbiol Rev. 2005 Oct;18(4):719-56 [16223955] Appl Environ Microbiol. 2007 Oct;73(20):6644-9 [17720821] Infect Immun. 2008 Feb;76(2):542-50 [18025092] Infect Immun. 2009 Aug;77(8):3244-8 [19506016] Infect Immun. 2010 May;78(5):2240-7 [20194597] Science. 2001 Sep 14;293(5537):2093-8 [11557893] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JB.05279-11 ER - TY - JOUR T1 - Medical history and the risk of biliary tract cancers in Shanghai, China: implications for a role of inflammation AN - 885057109; 15397681 AB - Several lines of evidence suggest that inflammation may play a role in the etiology of biliary tract cancers. To examine further the role of inflammation, we evaluated the associations between self-reported inflammatory-related medical conditions and the risk of biliary tract cancers in a population-based case-control study in Shanghai, China. Our analysis included 368 gallbladder cancer cases, 191 bile duct cancer cases, 68 ampulla of Vater cancer cases, and 959 healthy subjects. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for biliary tract cancers in relation to six inflammation-related conditions. Gallbladder cancer was significantly associated with cholecystitis occurring at least 5 years prior to interview (OR = 1.7, 95% CI 1.1-2.9). Even though biliary stones did not significantly modify the associations between cholecystitis and gallbladder cancer, 90% of the gallbladder cancer cases with cholecystitis also had biliary stones, indicating that stones likely play an important role in the link between cholecystitis and gallbladder cancer. Among subjects who smoked and drank alcohol, a history of gastric (OR = 4.3, 95% CI 1.2-15.0) or duodenal ulcers (OR = 3.7, 1.2-12.0) was associated with an excess risk of gallbladder cancer. Although the mechanisms are unclear, our results further support the role for inflammation in the etiology of biliary tract cancers. JF - Cancer Causes & Control AU - Andreotti, Gabriella AU - Liu, Enju AU - Gao, Yu-Tang AU - Safaeian, Mahboobeh AU - Rashid, Asif AU - Shen, Ming-Chang AU - Wang, Bin-Shen AU - Deng, Jie AU - Han, Tian-Quian AU - Zhang, Bai-He AU - Hsing, Ann W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., EPS 8011, MSC 7240, Bethesda, MD, 20892, USA, andreotg@mail.nih.gov andreotg@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1289 EP - 1296 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 22 IS - 9 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Historical account KW - Alcohol KW - Etiology KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885057109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Medical+history+and+the+risk+of+biliary+tract+cancers+in+Shanghai%2C+China%3A+implications+for+a+role+of+inflammation&rft.au=Andreotti%2C+Gabriella%3BLiu%2C+Enju%3BGao%2C+Yu-Tang%3BSafaeian%2C+Mahboobeh%3BRashid%2C+Asif%3BShen%2C+Ming-Chang%3BWang%2C+Bin-Shen%3BDeng%2C+Jie%3BHan%2C+Tian-Quian%3BZhang%2C+Bai-He%3BHsing%2C+Ann+W&rft.aulast=Andreotti&rft.aufirst=Gabriella&rft.date=2011-09-01&rft.volume=22&rft.issue=9&rft.spage=1289&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9802-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Alcohol; Historical account; Etiology; Cancer; China, People's Rep., Shanghai; China, People's Rep. DO - http://dx.doi.org/10.1007/s10552-011-9802-z ER - TY - JOUR T1 - Lactate dehydrogenase C and energy metabolism in mouse sperm. AN - 885055412; 21565994 AB - We demonstrated previously that disruption of the germ cell-specific lactate dehydrogenase C gene (Ldhc) led to male infertility due to defects in sperm function, including a rapid decline in sperm ATP levels, a decrease in progressive motility, and a failure to develop hyperactivated motility. We hypothesized that lack of LDHC disrupts glycolysis by feedback inhibition, either by causing a defect in renewal of the NAD(+) cofactor essential for activity of glyceraldehyde 3-phosphate dehydrogenase, sperm (GAPDHS), or an accumulation of pyruvate. To test these hypotheses, nuclear magnetic resonance analysis was used to follow the utilization of labeled substrates in real time. We found that in sperm lacking LDHC, glucose consumption was disrupted, but the NAD:NADH ratio and pyruvate levels were unchanged, and pyruvate was rapidly metabolized to lactate. Moreover, the metabolic disorder induced by treatment with the lactate dehydrogenase (LDH) inhibitor sodium oxamate was different from that caused by lack of LDHC. This supported our earlier conclusion that LDHA, an LDH isozyme present in the principal piece of the flagellum, is responsible for the residual LDH activity in sperm lacking LDHC, but suggested that LDHC has an additional role in the maintenance of energy metabolism in sperm. By coimmunoprecipitation coupled with mass spectrometry, we identified 27 proteins associated with LDHC. A majority of these proteins are implicated in ATP synthesis, utilization, transport, and/or sequestration. This led us to hypothesize that in addition to its role in glycolysis, LDHC is part of a complex involved in ATP homeostasis that is disrupted in sperm lacking LDHC. JF - Biology of reproduction AU - Odet, Fanny AU - Gabel, Scott A AU - Williams, Jason AU - London, Robert E AU - Goldberg, Erwin AU - Eddy, Edward M AD - Laboratories of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709-2233, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 556 EP - 564 VL - 85 IS - 3 KW - Carbon Isotopes KW - 0 KW - Isoenzymes KW - NAD KW - 0U46U6E8UK KW - Pyruvic Acid KW - 8558G7RUTR KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - lactate dehydrogenase C4 KW - EC 1.1.1.27.- KW - Glucose KW - IY9XDZ35W2 KW - Oxamic Acid KW - QU60N5OPLG KW - Index Medicus KW - Animals KW - Mass Spectrometry KW - Glucose -- metabolism KW - Immunoprecipitation KW - Mice KW - Isoenzymes -- metabolism KW - Membrane Potential, Mitochondrial KW - Mice, Knockout KW - Magnetic Resonance Spectroscopy KW - Isoenzymes -- antagonists & inhibitors KW - NAD -- metabolism KW - Adenosine Triphosphate -- metabolism KW - Carbon Isotopes -- analysis KW - Pyruvic Acid -- metabolism KW - Male KW - Spermatozoa -- metabolism KW - L-Lactate Dehydrogenase -- antagonists & inhibitors KW - Glycolysis KW - L-Lactate Dehydrogenase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885055412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+reproduction&rft.atitle=Lactate+dehydrogenase+C+and+energy+metabolism+in+mouse+sperm.&rft.au=Odet%2C+Fanny%3BGabel%2C+Scott+A%3BWilliams%2C+Jason%3BLondon%2C+Robert+E%3BGoldberg%2C+Erwin%3BEddy%2C+Edward+M&rft.aulast=Odet&rft.aufirst=Fanny&rft.date=2011-09-01&rft.volume=85&rft.issue=3&rft.spage=556&rft.isbn=&rft.btitle=&rft.title=Biology+of+reproduction&rft.issn=1529-7268&rft_id=info:doi/10.1095%2Fbiolreprod.111.091546 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-12 N1 - Date created - 2011-08-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Reprod Fertil. 2000 Jan;118(1):127-35 [10793634] Int J Biochem Cell Biol. 2010 May;42(5):623-9 [20060930] J Biol Chem. 2001 Mar 9;276(10):7630-6 [11115497] J Androl. 2001 Jul-Aug;22(4):680-95 [11451366] Reproduction. 2003 Jan;125(1):17-26 [12622692] FEBS Lett. 2003 Nov 20;554(3):342-6 [14623091] Biol Reprod. 2004 Aug;71(2):540-7 [15084484] Diabetes. 1967 Apr;16(4):252-8 [4290244] J Exp Zool. 1970 Jun;174(2):173-86 [4393121] J Anim Sci. 1976 Jul;43(1):159-63 [939721] J Biol Chem. 1978 Dec 10;253(23):8465-9 [711761] Cell Biochem Funct. 1984 Jul;2(3):131-4 [6383647] Biol Reprod. 1985 Jun;32(5):1201-10 [2410040] Biol Reprod. 1986 Mar;34(2):349-56 [3082381] Biol Reprod. 1989 Jan;40(1):173-80 [2923949] Exp Clin Immunogenet. 1985;2(2):120-4 [2856184] J Theor Biol. 1991 Sep 7;152(1):103-7 [1753751] Biol Reprod. 1996 Oct;55(4):917-22 [8879509] J Cell Sci. 1997 Aug;110 ( Pt 15):1821-9 [9264469] Biol Reprod. 1997 Oct;57(4):791-5 [9314582] Mol Reprod Dev. 1998 Apr;49(4):374-85 [9508088] Methods. 1999 Oct;19(2):306-21 [10527733] Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16501-6 [15546993] Stem Cells. 2005 Oct;23(9):1314-23 [16051982] Hum Reprod Update. 2006 May-Jun;12(3):269-74 [16407453] Proteins. 2006 May 15;63(3):501-11 [16444750] J Androl. 2006 Jul-Aug;27(4):502-9 [16582413] Biol Reprod. 2006 Aug;75(2):270-8 [16687649] Biol Reprod. 2006 Nov;75(5):767-77 [16855207] Dev Biol. 2007 Feb 15;302(2):463-76 [17137571] Soc Reprod Fertil Suppl. 2007;65:309-25 [17644971] J Biol Chem. 2007 Oct 5;282(40):29658-66 [17681941] Biol Reprod. 2008 Jul;79(1):26-34 [18367675] Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17718-23 [19008351] Reproduction. 2009 Sep;138(3):463-70 [19556438] Biol Reprod. 2010 Jan;82(1):136-45 [19759366] Biol Reprod. 2010 Mar;82(3):504-15 [19889946] Biol Reprod. 2001 May;64(5):1350-7 [11319138] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1095/biolreprod.111.091546 ER - TY - JOUR T1 - Magnetic resonance imaging quantification of regional cerebral blood flow and cerebrovascular reactivity to carbon dioxide in normotensive and hypertensive rats AN - 885052034; 15458429 AB - Hypertension afflicts 25% of the general population and over 50% of the elderly. In the present work, arterial spin labeling MRI was used to non-invasively quantify regional cerebral blood flow (CBF), cerebrovascular resistance and CO sub(2 reactivity in spontaneously hypertensive rats (SHR) and in normotensive Wistar Kyoto rats (WKY), at two different ages (3 months and 10 months) and under the effects of two anesthetics, alpha -chloralose and 2% isoflurane (1.5 MAC). Repeated CBF measurements were highly consistent, differing by less than 10% and 18% within and across animals, respectively. Under alpha -chloralose, whole brain CBF at normocapnia did not differ between groups (young WKY: 61 +/- 3 ml/100 g/min; adult WKY: 62 +/- 4 ml/100 g/min; young SHR: 70 +/- 9 ml/100 g/min; adult SHR: 69 +/- 8 ml/100 g/min), indicating normal cerebral autoregulation in SHR. At hypercapnia, CBF values increased significantly, and a linear relationship between CBF and PaCO) sub(2) levels was observed. In contrast, 2% isoflurane impaired cerebral autoregulation. Whole brain CBF in SHR was significantly higher than in WKY rats at normocapnia (young SHR: 139 +/- 25 ml/100 g/min; adult SHR: 104 +/- 23 ml/100 g/min; young WKY: 55 +/- 9 ml/100 g/min; adult WKY: 71 +/- 19 ml/100 g/min). CBF values increased significantly with increasing CO sub(2; however, there was a clear saturation of CBF at PaCO) sub(2) levels greater than 70 mm Hg in both young and adult rats, regardless of absolute CBF values, suggesting that isoflurane interferes with the vasodilatory mechanisms of CO sub(2. This behavior was observed for both cortical and subcortical structures. Under either anesthetic, CO) sub(2) reactivity values in adult SHR were decreased, confirming that hypertension, when combined with age, increases cerebrovascular resistance and reduces cerebrovascular compliance. JF - NeuroImage AU - Leoni, Renata F AU - Paiva, Fernando F AU - Henning, Erica C AU - Nascimento, George C AU - Tannus, Alberto AU - De Araujo, Draulio B AU - Silva, Afonso C Y1 - 2011/09/01/ PY - 2011 DA - 2011 Sep 01 SP - 75 EP - 81 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 58 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Age KW - Cerebral blood flow KW - W 30910:Imaging KW - N3:11027 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885052034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Magnetic+resonance+imaging+quantification+of+regional+cerebral+blood+flow+and+cerebrovascular+reactivity+to+carbon+dioxide+in+normotensive+and+hypertensive+rats&rft.au=Leoni%2C+Renata+F%3BPaiva%2C+Fernando+F%3BHenning%2C+Erica+C%3BNascimento%2C+George+C%3BTannus%2C+Alberto%3BDe+Araujo%2C+Draulio+B%3BSilva%2C+Afonso+C&rft.aulast=Leoni&rft.aufirst=Renata&rft.date=2011-09-01&rft.volume=58&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2011.06.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Cerebral blood flow DO - http://dx.doi.org/10.1016/j.neuroimage.2011.06.030 ER - TY - JOUR T1 - Infratentorial craniospinal irradiation for von Hippel-Lindau: a retrospective study supporting a new treatment for patients with CNS hemangioblastomas. AN - 884426223; 21798886 AB - Patients with von Hippel-Lindau (VHL) syndrome with diffuse CNS hemangioblastomas have morbidity related to their disease and require a lifetime of surgical resections. Ninety-seven percent of tumors progress, and 5-year surgery rates are 20%-60%. Stereotactic radiosurgery and fractionated radiotherapy have had limited success. For the first time, we have used infratentorial craniospinal radiation therapy (ICSRT) for VHL patients with CNS hemangioblastomas. Consecutive VHL patients treated at the National Institutes of Health with radiographic evidence of hemangioblastomas were included if they received ICSRT. Patients underwent neurologic examinations and imaging at 3- to 12-month intervals. Seven patients with 84 hemangioblastomas met eligibility criteria. ICSRT was commonly administered to 43.2 Gy in 24 fractions. Mean pre-ICSRT tumor volume was 5.48 cm(3). At a mean follow-up of 73.8 months, mean post-ICSRT tumor volume was 6.87 cm(3), and 91 tumors were identified. Complete radiographic resolution was achieved in 17.9% of lesions. Although many patients were no longer optimal surgical candidates, only 4 surgeries were needed for symptomatic lesions after ICSRT, compared with 33 prior. Acute toxicity was mild and no patient developed grade ≥1 late spinal cord toxicity according to the criteria of the Radiation Therapy Oncology Group/European Organisation for Research and Treatment of Cancer, despite the high dose that the entire spinal cord received. Clinical and radiographic stability or resolution was demonstrated in the majority of tumors. Tumor growth rate in this study was less than reported in natural history studies, and the rate of surgical intervention was reduced. ICSRT was well tolerated, can decrease hemangioblastoma growth rate, and is a potential therapeutic option for VHL patients that warrants further investigation. JF - Neuro-oncology AU - Simone, Charles B AU - Lonser, Russell R AU - Ondos, John AU - Oldfield, Edward H AU - Camphausen, Kevin AU - Simone, Nicole L AD - National Institutes of Health, National Cancer Institute, Radiation Oncology Branch, Bethesda, MD 20892, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 1030 EP - 1036 VL - 13 IS - 9 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Survival Rate KW - Combined Modality Therapy KW - Humans KW - Adult KW - Treatment Outcome KW - Retrospective Studies KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Spinal Cord Neoplasms -- radiotherapy KW - Hemangioblastoma -- etiology KW - Hemangioblastoma -- surgery KW - Cranial Irradiation KW - von Hippel-Lindau Disease -- radiotherapy KW - Spinal Cord Neoplasms -- etiology KW - Infratentorial Neoplasms -- radiotherapy KW - Spinal Cord Neoplasms -- surgery KW - Infratentorial Neoplasms -- surgery KW - Hemangioblastoma -- radiotherapy KW - Infratentorial Neoplasms -- etiology KW - Cerebellar Neoplasms -- etiology KW - Cerebellar Neoplasms -- radiotherapy KW - Cerebellar Neoplasms -- surgery KW - von Hippel-Lindau Disease -- surgery KW - von Hippel-Lindau Disease -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/884426223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuro-oncology&rft.atitle=Infratentorial+craniospinal+irradiation+for+von+Hippel-Lindau%3A+a+retrospective+study+supporting+a+new+treatment+for+patients+with+CNS+hemangioblastomas.&rft.au=Simone%2C+Charles+B%3BLonser%2C+Russell+R%3BOndos%2C+John%3BOldfield%2C+Edward+H%3BCamphausen%2C+Kevin%3BSimone%2C+Nicole+L&rft.aulast=Simone&rft.aufirst=Charles&rft.date=2011-09-01&rft.volume=13&rft.issue=9&rft.spage=1030&rft.isbn=&rft.btitle=&rft.title=Neuro-oncology&rft.issn=1523-5866&rft_id=info:doi/10.1093%2Fneuonc%2Fnor085 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-08 N1 - Date created - 2011-08-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Radiat Oncol Biol Phys. 1990 May;18(5):1165-71 [2347723] J Neurosurg. 1989 Jan;70(1):24-30 [2909683] Radiology. 1995 Mar;194(3):629-42 [7862955] J Neurosurg. 2006 Aug;105(2):248-55 [17219830] Clin Neurosurg. 2006;53:324-31 [17380770] Int J Radiat Oncol Biol Phys. 2007 Dec 1;69(5):1521-6 [17869023] Neurosurgery. 2001 Aug;49(2):321-7; discussion 327-8 [11504107] Neurosurgery. 2001 Jan;48(1):55-62; discussion 62-3 [11152361] Neuro Oncol. 2010 Jan;12(1):80-6 [20150370] J Neurosurg. 2003 Jan;98(1):82-94 [12546356] J Neurosurg. 2003 Jan;98(1):95-105 [12546357] J Neurosurg. 2003 Jan;98(1):106-16 [12546358] AJNR Am J Neuroradiol. 2003 Sep;24(8):1570-4 [13679272] Cancer Res. 2003 Nov 1;63(21):7051-5 [14612494] Neurosurgery. 2003 Dec;53(6):1306-13; discussion 1313-4 [14633297] Cancer. 1982 Feb 1;49(3):553-5 [7199372] Surg Neurol. 1986 Mar;25(3):269-75 [3945908] Int J Radiat Oncol Biol Phys. 1993 Jan 15;25(2):381-5 [8420891] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/neuonc/nor085 ER - TY - JOUR T1 - Biweekly rituximab, cyclophosphamide, vincristine, non-pegylated liposome-encapsulated doxorubicin and prednisone (R-COMP-14) in elderly patients with poor-risk diffuse large B-cell lymphoma and moderate to high 'life threat' impact cardiopathy. AN - 883310588; 21707585 AB - This Phase II study assessed feasibility and efficacy of a biweekly R-COMP-14 regimen (rituximab, cyclophosphamide, non-pegylated liposome-encapsulated doxorubicin, vincristine and prednisone) in untreated elderly patients with poor-risk diffuse large B-cell lymphoma (DLBCL) and moderate to high 'life threat' impact NIA/NCI cardiac comorbidity. A total of 208 courses were delivered, with close cardiac monitoring, to 41 patients (median age: 73years, range: 62-82; 37% >75years) at a median interval of 15·6 (range, 13-29) days; 67% completed all six scheduled courses. Response rate was 73%, with 68% complete responses (CR); 4-year disease-free survival (DFS) and time to treatment failure (TTF) were 72% and 49%, respectively. Failures were due to early death (n=3), therapy discontinuations (no-response n=2; toxicity n=6), relapse (n=6) and death in CR (n=3). Incidence of cardiac grade 3-5 adverse events was 7/41 (17%; 95% confidence interval: 8-31%). Time to progression and overall survival at 4-years were 77% and 67%, respectively. The Age-adjusted Charlson Comorbidity Index (aaCCI) correlated with failures (P=0·007) with patients scoring ≤7 having a longer TTF (66% vs. 29%; P=0·009). R-COMP-14 is feasible and ensures a substantial DFS to poor-risk DLBCL patients who would have been denied anthracycline-based treatment due to cardiac morbidity. The aaCCI predicted both treatment discontinuation rate and TTF. © 2011 Blackwell Publishing Ltd. JF - British journal of haematology AU - Corazzelli, Gaetano AU - Frigeri, Ferdinando AU - Arcamone, Manuela AU - Lucania, Anna AU - Rosariavilla, Maria AU - Morelli, Emanuela AU - Amore, Alfonso AU - Capobianco, Gaetana AU - Caronna, Antonietta AU - Becchimanzi, Cristina AU - Volzone, Francesco AU - Marcacci, Gianpaolo AU - Russo, Filippo AU - De Filippi, Rosaria AU - Mastrullo, Lucia AU - Pinto, Antonio AD - Haematology-Oncology and Stem Cell Transplantation Unit, National Cancer Institute, Fondazione G. Pascale, IRCCS, Naples, Italy. g.corazzelli@istitutotumori.na.it Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 579 EP - 589 VL - 154 IS - 5 KW - Antibodies, Monoclonal, Murine-Derived KW - 0 KW - liposomal doxorubicin KW - Polyethylene Glycols KW - 30IQX730WE KW - Rituximab KW - 4F4X42SYQ6 KW - Vincristine KW - 5J49Q6B70F KW - Doxorubicin KW - 80168379AG KW - Cyclophosphamide KW - 8N3DW7272P KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Doxorubicin -- analogs & derivatives KW - Humans KW - Vincristine -- administration & dosage KW - Prognosis KW - Aged KW - Doxorubicin -- administration & dosage KW - Polyethylene Glycols -- administration & dosage KW - Comorbidity KW - Risk KW - Aged, 80 and over KW - Antibodies, Monoclonal, Murine-Derived -- administration & dosage KW - Treatment Outcome KW - Middle Aged KW - Prednisone -- administration & dosage KW - Female KW - Male KW - Survival Analysis KW - Lymphoma, Large B-Cell, Diffuse -- complications KW - Heart Diseases -- epidemiology KW - Heart Diseases -- drug therapy KW - Lymphoma, Large B-Cell, Diffuse -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883310588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+haematology&rft.atitle=Biweekly+rituximab%2C+cyclophosphamide%2C+vincristine%2C+non-pegylated+liposome-encapsulated+doxorubicin+and+prednisone+%28R-COMP-14%29+in+elderly+patients+with+poor-risk+diffuse+large+B-cell+lymphoma+and+moderate+to+high+%27life+threat%27+impact+cardiopathy.&rft.au=Corazzelli%2C+Gaetano%3BFrigeri%2C+Ferdinando%3BArcamone%2C+Manuela%3BLucania%2C+Anna%3BRosariavilla%2C+Maria%3BMorelli%2C+Emanuela%3BAmore%2C+Alfonso%3BCapobianco%2C+Gaetana%3BCaronna%2C+Antonietta%3BBecchimanzi%2C+Cristina%3BVolzone%2C+Francesco%3BMarcacci%2C+Gianpaolo%3BRusso%2C+Filippo%3BDe+Filippi%2C+Rosaria%3BMastrullo%2C+Lucia%3BPinto%2C+Antonio&rft.aulast=Corazzelli&rft.aufirst=Gaetano&rft.date=2011-09-01&rft.volume=154&rft.issue=5&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=British+journal+of+haematology&rft.issn=1365-2141&rft_id=info:doi/10.1111%2Fj.1365-2141.2011.08786.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-27 N1 - Date created - 2011-08-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 2007 May 10;25(14):1916-23 [17488991] Ann Oncol. 2011 Feb;22(2):257-67 [20956616] Hematol Oncol. 2007 Dec;25(4):198-203 [17654614] Lancet Oncol. 2008 Feb;9(2):105-16 [18226581] Clin Lymphoma Myeloma. 2007 Dec;8 Suppl 2:S43-9 [18284715] Hematol Oncol. 2008 Mar;26(1):27-32 [17868190] Ann Oncol. 2008 Apr;19(4):774-9 [18065404] Clin Res Cardiol. 2008 May;97(5):318-26 [18193371] Exp Oncol. 2008 Jun;30(2):160-2 [18566583] Leuk Lymphoma. 2008 Jun;49(6):1081-6 [18569635] J Clin Oncol. 2008 Jul 1;26(19):3159-65 [18591554] J Clin Oncol. 2009 Jan 1;27(1):127-45 [19018081] Lancet Oncol. 2009 Apr;10(4):391-9 [19341970] Intensive Care Med. 2000 Jan;26(1):31-7 [10663277] Clin Chem. 2000 May;46(5):650-7 [10794747] J Clin Oncol. 2001 Mar 1;19(5):1444-54 [11230490] Intensive Care Med. 2001 Jun;27(6):965-9 [11497154] Br J Cancer. 2002 Jun 5;86(11):1697-700 [12087452] Anticancer Res. 2002 May-Jun;22(3):1845-8 [12168880] Ann Oncol. 2003 Feb;14(2):277-81 [12562656] Circulation. 2003 Sep 2;108(9):1146-62 [12952829] Circulation. 2003 Sep 16;108(11):1404-18 [12975245] Cancer Control. 2003 Sep-Oct;10(5):396-403 [14581895] J Clin Oncol. 2004 Mar 1;22(5):769-73 [14990630] J Clin Oncol. 2004 Jul 1;22(13):2662-70 [15226333] Blood. 2004 Aug 1;104(3):634-41 [15016643] Curr Cardiol Rep. 2004 Sep;6(5):379-84 [15306095] N Engl J Med. 2004 Sep 9;351(11):1053-6 [15356302] J Chronic Dis. 1987;40(5):373-83 [3558716] Am J Med. 1987 Jun;82(6):1109-18 [3605130] N Engl J Med. 1993 Sep 30;329(14):987-94 [8141877] Biometrics. 1995 Dec;51(4):1372-83 [8589229] Cancer. 1998 Jun 1;82(11):2123-34 [9610691] Am J Emerg Med. 1999 May;17(3):225-9 [10337875] Lancet Oncol. 2004 Nov;5(11):654 [15522651] BMC Cancer. 2004 Dec 20;4:94 [15610554] Semin Oncol. 2004 Dec;31(6 Suppl 13):5-15 [15717735] Br J Haematol. 2005 Jun;129(5):597-606 [15916681] J Clin Oncol. 2005 Jun 20;23(18):4117-26 [15867204] Ann Oncol. 2006 Jun;17(6):928-34 [16507563] Semin Oncol. 2006 Jun;33(3 Suppl 8):S2-7 [16781283] Semin Oncol. 2006 Jun;33(3 Suppl 8):S22-7 [16781286] Cancer. 2006 Oct 1;107(7):1530-41 [16933332] Leuk Lymphoma. 2006 Oct;47(10):2174-80 [17071492] Circulation. 2006 Dec 5;114(23):2474-81 [17101852] J Clin Oncol. 2007 Feb 10;25(5):579-86 [17242396] Cancer Chemother Pharmacol. 2009 Oct;64(5):907-16 [19219604] J Natl Cancer Inst. 2010 Jan 6;102(1):14-25 [20007921] Leuk Lymphoma. 2010 May;51(5):737-8 [20367567] J Clin Oncol. 2010 May 10;28(14):2373-80 [20385988] Ann Oncol. 2010 Jul;21(7):1492-9 [20007997] Ann Hematol. 2010 Sep;89(9):897-904 [20414658] Blood. 2007 Aug 1;110(3):972-8 [17400912] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2141.2011.08786.x ER - TY - JOUR T1 - Comparative toxicology of mercurials in Caenorhabditis elegans. AN - 883307091; 21692103 AB - Mercury (Hg) is a toxic metal that can exist in multiple chemical species. Humans are commonly exposed to methylmercury and Hg vapor, which are converted to mercuric species in the body. Despite years of research, little information exists on the similarities and differences in the mechanisms of Hg toxicity. The relative toxicity of mercuric chloride (HgCl(2)) and methylmercury chloride (MeHgCl) in Caenorhabditis elegans was determined in assays that measured growth, feeding, reproduction, and locomotion. The effect of HgCl(2) and MeHgCl on the expression of several archetypal stress-response genes was also determined. There was no significant difference between the EC50s of the two mercurials in terms of C. elegans growth. However, MeHgCl was more toxic to C. elegans than HgCl(2) when assessing feeding, movement, and reproduction, all of which require proper neuromuscular activity. Methylmercury chloride exposure resulted in increased steady-state levels of the stress response genes at lower concentrations than HgCl(2). In general, MeHgCl was more toxic to C. elegans than HgCl(2), particularly when assaying behaviors that require neuromuscular function. Copyright © 2011 SETAC. JF - Environmental toxicology and chemistry AU - McElwee, Matthew K AU - Freedman, Jonathan H AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 2135 EP - 2141 VL - 30 IS - 9 KW - Caenorhabditis elegans Proteins KW - 0 KW - Methylmercury Compounds KW - RNA, Messenger KW - Water Pollutants, Chemical KW - methylmercuric chloride KW - RWZ4L3O1X0 KW - Index Medicus KW - Gene Expression -- drug effects KW - Behavior, Animal -- drug effects KW - Animals KW - RNA, Messenger -- metabolism KW - Caenorhabditis elegans Proteins -- genetics KW - Reproduction -- drug effects KW - Caenorhabditis elegans -- growth & development KW - Caenorhabditis elegans -- drug effects KW - Water Pollutants, Chemical -- toxicity KW - Caenorhabditis elegans -- metabolism KW - Methylmercury Compounds -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883307091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Comparative+toxicology+of+mercurials+in+Caenorhabditis+elegans.&rft.au=McElwee%2C+Matthew+K%3BFreedman%2C+Jonathan+H&rft.aulast=McElwee&rft.aufirst=Matthew&rft.date=2011-09-01&rft.volume=30&rft.issue=9&rft.spage=2135&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.603 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-27 N1 - Date created - 2011-08-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Methods Mol Biol. 2000;132:365-86 [10547847] Toxicol Sci. 2010 Dec;118(2):613-24 [20855423] Cell Biol Toxicol. 2000;16(6):347-62 [11254161] Methods. 2001 Dec;25(4):402-8 [11846609] Toxicol Sci. 2002 Apr;66(2):261-73 [11896293] Prog Mol Subcell Biol. 2002;28:61-78 [11908066] Cell Calcium. 2003 Sep;34(3):285-93 [12887976] J Biochem Mol Toxicol. 2003;17(5):249-54 [14595846] Ann Clin Res. 1973 Aug;5(4):214-9 [4203781] Dev Biol. 1976 Mar;49(1):200-19 [943344] Pharmacol Biochem Behav. 1976 Apr;4(4):385-91 [935210] Philos Trans R Soc Lond B Biol Sci. 1976 Aug 10;275(938):299-325 [8805] Teratology. 1978 Oct;18(2):285-8 [362594] Toxicol Ind Health. 1988 Dec;4(4):469-78 [3188044] J Pharmacol Exp Ther. 1995 Mar;272(3):1016-23 [7891311] Environ Res. 1998 May;77(2):73-8 [9600798] J Biol Chem. 1998 Nov 27;273(48):31962-70 [9822667] J Exp Zool. 1999 Jul 1;284(2):147-57 [10404644] Arch Toxicol. 2004 Oct;78(10):565-74 [15150681] Arch Toxicol. 2004 Oct;78(10):575-83 [15205888] Arch Environ Contam Toxicol. 2005 May;48(4):490-4 [15886897] Biometals. 2005 Oct;18(5):519-28 [16333752] Neurotoxicology. 2006 Jul;27(4):492-500 [16513172] Nat Rev Drug Discov. 2006 May;5(5):387-98 [16672925] Ann Clin Biochem. 2006 Jul;43(Pt 4):257-68 [16824275] Crit Rev Toxicol. 2006 Sep;36(8):609-62 [16973445] Toxicol Sci. 2006 Nov;94(1):129-38 [16896058] Brain Res. 2007 Feb 2;1131(1):1-10 [17182013] J Neurol Sci. 2007 Nov 15;262(1-2):131-44 [17681548] Toxicol In Vitro. 2007 Oct;21(7):1258-61 [17553660] PLoS One. 2007;2(12):e1259 [18060055] Toxicol Sci. 2008 Feb;101(2):215-25 [17989133] Genome Biol. 2007;8(6):R122 [17592649] Arch Environ Occup Health. 2007 Fall;62(3):121-8 [18400651] Toxicol Sci. 2008 Nov;106(1):5-28 [18566021] Environ Sci Technol. 2009 Apr 15;43(8):2983-8 [19475981] Neurochem Res. 2009 Sep;34(9):1677-84 [19347580] PLoS One. 2009;4(9):e7024 [19753116] Toxicol Appl Pharmacol. 2009 Oct 15;240(2):265-72 [19341752] Neurotoxicol Teratol. 2010 Jan-Feb;32(1):68-73 [19166924] Toxicol Appl Pharmacol. 2010 Jun 1;245(2):153-9 [20206647] Toxicol Sci. 2001 Feb;59(2):278-90 [11158721] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/etc.603 ER - TY - JOUR T1 - Controlled biodegradation of Self-assembling beta -hairpin Peptide hydrogels by proteolysis with matrix metalloproteinase-13 AN - 883036621; 15332208 AB - Controlled biodegradation specific to matrix metalloproteinase-13 was incorporated into the design of self-assembling beta -hairpin peptide hydrogels. Degrading Peptides (DP peptides) are a series of five peptides that have varying proteolytic susceptibilities toward MMP-13. These peptides undergo environmentally triggered folding and self-assembly under physiologically relevant conditions (150 mm NaCl, pH 7.6) to form self-supporting hydrogels. In the presence of enzyme, gels prepared from distinct peptides are degraded at rates that differ according to the primary sequence of the single peptide comprising the gel. Material degradation was monitored by oscillatory shear rheology over the course of 14 days, where overall degradation of the gels vary from 5% to 70%. Degradation products were analyzed by HPLC and identified by electrospray-ionization mass spectrometry. This data shows that proteolysis of the parent peptides constituting each gel occurs at the intended sequence location. DP hydrogels show specificity to MMP-13 and are only minimally cleaved by matrix metalloproteinase-3 (MMP-3), another common enzyme present during tissue injury. In vitro migration assays performed with SW1353 cells show that migration rates through each gel differs according to peptide sequence, which is consistent with the proteolysis studies using exogenous MMP-13. JF - Biomaterials AU - Giano, Michael C AU - Pochan, Darrin J AU - Schneider, Joel P AD - National Cancer Institute, Center for Cancer Research, Frederick, MD 21701, USA Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 6471 EP - 6477 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 32 IS - 27 SN - 0142-9612, 0142-9612 KW - Toxicology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - Biodegradation KW - Matrix metalloproteinase KW - Peptide KW - Self assembly KW - Hydrogel KW - Extracellular matrix KW - High-performance liquid chromatography KW - Proteolysis KW - Data processing KW - Stromelysin 1 KW - Injuries KW - Enzymes KW - Mass spectroscopy KW - Rheology KW - hydrogels KW - Self-assembly KW - Collagenase 3 KW - Cell migration KW - pH effects KW - Sodium chloride KW - Degradation products KW - Amino acid sequence KW - X 24360:Metals KW - A 01320:Microbial Degradation KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883036621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=Controlled+biodegradation+of+Self-assembling+beta+-hairpin+Peptide+hydrogels+by+proteolysis+with+matrix+metalloproteinase-13&rft.au=Giano%2C+Michael+C%3BPochan%2C+Darrin+J%3BSchneider%2C+Joel+P&rft.aulast=Giano&rft.aufirst=Michael&rft.date=2011-09-01&rft.volume=32&rft.issue=27&rft.spage=6471&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=01429612&rft_id=info:doi/10.1016%2Fj.biomaterials.2011.05.052 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Proteolysis; High-performance liquid chromatography; Biodegradation; Stromelysin 1; Data processing; Injuries; Enzymes; Mass spectroscopy; Rheology; hydrogels; Self-assembly; Collagenase 3; Cell migration; pH effects; Sodium chloride; Amino acid sequence; Degradation products DO - http://dx.doi.org/10.1016/j.biomaterials.2011.05.052 ER - TY - JOUR T1 - Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01. AN - 882089772; 21715490 AB - The structure of VRC01 in complex with the HIV-1 gp120 core reveals that this broadly neutralizing CD4 binding site (CD4bs) antibody partially mimics the interaction of the primary virus receptor, CD4, with gp120. Here, we extended the investigation of the VRC01-gp120 core interaction to the biologically relevant viral spike to better understand the mechanism of VRC01-mediated neutralization and to define viral elements associated with neutralization resistance. In contrast to the interaction of CD4 or the CD4bs monoclonal antibody (MAb) b12 with the HIV-1 envelope glycoprotein (Env), occlusion of the VRC01 epitope by quaternary constraints was not a major factor limiting neutralization. Mutagenesis studies indicated that VRC01 contacts within the gp120 loop D, the CD4 binding loop, and the V5 region were necessary for optimal VRC01 neutralization, as suggested by the crystal structure. In contrast to interactions with the soluble gp120 monomer, VRC01 interaction with the native viral spike did not occur in a CD4-like manner; VRC01 did not induce gp120 shedding from the Env spike or enhance gp41 membrane proximal external region (MPER)-directed antibody binding to the Env spike. Finally, VRC01 did not display significant reactivity with human antigens, boding well for potential in vivo applications. The data indicate that VRC01 interacts with gp120 in the context of the functional spike in a manner distinct from that of CD4. It achieves potent neutralization by precisely targeting the CD4bs without requiring alterations of Env spike configuration and by avoiding steric constraints imposed by the quaternary structure of the functional Env spike. JF - Journal of virology AU - Li, Yuxing AU - O'Dell, Sijy AU - Walker, Laura M AU - Wu, Xueling AU - Guenaga, Javier AU - Feng, Yu AU - Schmidt, Stephen D AU - McKee, Krisha AU - Louder, Mark K AU - Ledgerwood, Julie E AU - Graham, Barney S AU - Haynes, Barton F AU - Burton, Dennis R AU - Wyatt, Richard T AU - Mascola, John R AD - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 8954 EP - 8967 VL - 85 IS - 17 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Neutralizing KW - HIV Envelope Protein gp120 KW - Mutant Proteins KW - gp120 protein, Human immunodeficiency virus 1 KW - Index Medicus KW - Mutant Proteins -- genetics KW - Mutagenesis, Site-Directed KW - Models, Molecular KW - Mutant Proteins -- metabolism KW - Humans KW - Neutralization Tests KW - Enzyme-Linked Immunosorbent Assay KW - Protein Binding KW - Mutant Proteins -- immunology KW - Binding Sites KW - HIV-1 -- immunology KW - HIV Envelope Protein gp120 -- immunology KW - HIV Envelope Protein gp120 -- metabolism KW - HIV Envelope Protein gp120 -- genetics KW - Antibodies, Neutralizing -- immunology KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/882089772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Mechanism+of+neutralization+by+the+broadly+neutralizing+HIV-1+monoclonal+antibody+VRC01.&rft.au=Li%2C+Yuxing%3BO%27Dell%2C+Sijy%3BWalker%2C+Laura+M%3BWu%2C+Xueling%3BGuenaga%2C+Javier%3BFeng%2C+Yu%3BSchmidt%2C+Stephen+D%3BMcKee%2C+Krisha%3BLouder%2C+Mark+K%3BLedgerwood%2C+Julie+E%3BGraham%2C+Barney+S%3BHaynes%2C+Barton+F%3BBurton%2C+Dennis+R%3BWyatt%2C+Richard+T%3BMascola%2C+John+R&rft.aulast=Li&rft.aufirst=Yuxing&rft.date=2011-09-01&rft.volume=85&rft.issue=17&rft.spage=8954&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.00754-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-04 N1 - Date created - 2011-08-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2003 Mar 20;422(6929):307-12 [12646921] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4144-9 [12644702] Virology. 2003 Sep 1;313(2):387-400 [12954207] Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5036-41 [15051887] Nature. 1984 Dec 20-1985 Jan 2;312(5996):763-7 [6096719] Nature. 1984 Dec 20-1985 Jan 2;312(5996):767-8 [6083454] Science. 1986 Jan 24;231(4736):382-5 [3001934] J Virol. 1989 Jun;63(6):2674-9 [2786089] Proc Natl Acad Sci U S A. 1990 Jan;87(2):648-52 [2300552] J Virol. 1990 Nov;64(11):5674-7 [2214033] Science. 1990 Nov 23;250(4984):1139-42 [2251501] J Virol. 1991 Mar;65(3):1133-40 [1995942] Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2189-93 [2006155] J Acquir Immune Defic Syndr. 1991;4(9):923-4 [1895215] J Virol. 1993 Mar;67(3):1461-71 [8437224] J Virol. 1994 May;68(5):3015-26 [7512157] AIDS Res Hum Retroviruses. 1994 Apr;10(4):359-69 [7520721] Science. 1994 Nov 11;266(5187):1024-7 [7973652] Nat Struct Biol. 1995 Dec;2(12):1075-82 [8846219] J Virol. 1996 Feb;70(2):1100-8 [8551569] J Virol. 1996 Mar;70(3):1863-72 [8627711] Science. 1996 May 10;272(5263):872-7 [8629022] Nature. 1996 Jun 20;381(6584):661-6 [8649511] Nature. 1996 Jun 20;381(6584):667-73 [8649512] Cell. 1996 Jun 28;85(7):1135-48 [8674119] Cell. 1996 Jun 28;85(7):1149-58 [8674120] Science. 1996 Jun 28;272(5270):1955-8 [8658171] Nature. 1996 Nov 14;384(6605):179-83 [8906795] Nature. 1996 Nov 14;384(6605):184-7 [8906796] J Virol. 1997 May;71(5):3734-41 [9094648] Cell. 1997 Apr 18;89(2):263-73 [9108481] Nature. 1997 May 22;387(6631):426-30 [9163431] Nat Struct Biol. 1998 Apr;5(4):276-9 [9546217] J Virol. 2005 Jan;79(2):1252-61 [15613352] Virology. 2005 Feb 5;332(1):145-56 [15661147] Science. 2005 Jun 24;308(5730):1906-8 [15860590] J Virol. 2005 Aug;79(16):10108-25 [16051804] Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13372-7 [16174734] Annu Rev Immunol. 2006;24:739-69 [16551265] Hum Antibodies. 2005;14(3-4):59-67 [16720975] Nature. 2007 Feb 15;445(7129):732-7 [17301785] J Virol. 2007 Jun;81(12):6548-62 [17409160] J Virol. 2007 Jun;81(12):6187-96 [17409164] J Mol Biol. 2007 Sep 7;372(1):16-22 [17631311] Nat Med. 2007 Sep;13(9):1032-4 [17721546] J Virol. 2008 Jan;82(2):638-51 [17959660] PLoS Med. 2008 Jan 3;5(1):e9 [18177204] Nature. 2008 Sep 4;455(7209):109-13 [18668044] J Virol. 2008 Dec;82(23):11651-68 [18815292] J Virol. 2009 Jan;83(2):757-69 [18987148] J Virol. 2009 Jan;83(2):1045-59 [19004942] J Virol. 2009 Jul;83(14):7337-48 [19439467] Nat Med. 2009 Aug;15(8):866-70 [19525964] J Virol. 2009 Sep;83(17):8925-37 [19553335] J Virol. 2009 Nov;83(21):10892-907 [19692465] Science. 2009 Oct 9;326(5950):285-9 [19729618] J Virol. 2010 Feb;84(3):1631-6 [19923174] Annu Rev Immunol. 2010;28:413-44 [20192810] J Virol. 2010 Jun;84(11):5637-55 [20335257] Nat Struct Mol Biol. 2010 May;17(5):608-13 [20357769] Science. 2010 Aug 13;329(5993):811-7 [20616231] Science. 2010 Aug 13;329(5993):856-61 [20616233] J Virol. 2010 Oct;84(20):10510-21 [20686044] Virology. 2010 Dec 20;408(2):213-23 [20961591] AIDS Res Hum Retroviruses. 2011 Aug;27(8):877-87 [21158699] Science. 1998 Jun 19;280(5371):1884-8 [9632381] Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9026-31 [10922058] J Virol. 2001 Mar;75(5):2041-50 [11160708] J Virol. 2001 Nov;75(22):10892-905 [11602729] J Virol. 2001 Nov;75(22):10906-11 [11602730] J Virol. 2002 Jul;76(14):7293-305 [12072528] J Virol. 2002 Jul;76(14):7306-21 [12072529] J Virol. 2003 Jan;77(1):642-58 [12477867] Nature. 2002 Dec 12;420(6916):678-82 [12478295] J Virol. 2003 Feb;77(3):1666-71 [12525600] J Biol Chem. 2003 Feb 28;278(9):7573-9 [12486032] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.00754-11 ER - TY - JOUR T1 - Toxicity and carcinogenicity of androstenedione in F344/N rats and B6C3F1 mice. AN - 880716943; 21651954 AB - Androstenedione was marketed as a dietary supplement to increase muscle mass during training. Due to concern over long-term use, the NTP evaluated the subchronic and chronic toxicity and carcinogenicity of androstenedione in male and female F344/N rats and B6C3F1 mice. In subchronic studies, dose limiting effects were not observed. A chronic (2-year) exposure by gavage at 10, 20, or 50 mg/kg in rats and male mice, and 2, 10, or 50 mg/kg in female mice (50 mg/kg, maximum feasible dose) was conducted. Increased incidences of lung alveolar/bronchiolar adenoma and carcinoma occurred in the 20 mg/kg male rats and increases in mononuclear cell leukemia occurred in the 20 and 50 mg/kg female rats, which may have been related to androstenedione administration. In male and female mice, androstenedione was carcinogenic based upon a significant increase in hepatocellular tumors. A marginal increase in pancreatic islet cell adenomas in male (50 mg/kg) and female (2, 10, 50 mg/kg) mice was considered to be related to androstenedione administration. Interestingly, incidences of male rat Leydig cell adenomas and female rat mammary gland fibroadenomas decreased. In conclusion, androstenedione was determined to be carcinogenic in male and female mice, and may have been carcinogenic in rats. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Blystone, Chad R AU - Elmore, Susan A AU - Witt, Kristine L AU - Malarkey, David E AU - Foster, Paul M D AD - National Toxicology Program, National Institutes of Environmental Health Sciences, National Institute of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, United States. blystonecr@niehs.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 2116 EP - 2124 VL - 49 IS - 9 KW - Carcinogens KW - 0 KW - Androstenedione KW - 409J2J96VR KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Dose-Response Relationship, Drug KW - Carcinogenicity Tests KW - Mice KW - Male KW - Female KW - Androstenedione -- toxicity KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/880716943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Toxicity+and+carcinogenicity+of+androstenedione+in+F344%2FN+rats+and+B6C3F1+mice.&rft.au=Blystone%2C+Chad+R%3BElmore%2C+Susan+A%3BWitt%2C+Kristine+L%3BMalarkey%2C+David+E%3BFoster%2C+Paul+M+D&rft.aulast=Blystone&rft.aufirst=Chad&rft.date=2011-09-01&rft.volume=49&rft.issue=9&rft.spage=2116&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2011.05.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-07 N1 - Date created - 2011-08-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Transplantation. 1980 Aug;30(2):90-6 [7010713] Cancer. 1980 Sep 15;46(6):1401-4 [6251960] Carcinogenesis. 1983 Sep;4(9):1179-83 [6349845] Endocrinology. 1984 Jun;114(6):2100-6 [6539197] Biol Reprod. 1984 Sep;31(2):221-30 [6089920] Mutat Res. 1986 Jul;171(1):31-41 [3724781] Chir Pediatr. 1987;28(2):97-101 [3040281] Cancer Res. 1988 May 15;48(10):2788-92 [2965969] IARC Monogr Eval Carcinog Risks Hum Suppl. 1987;7:1-440 [3482203] Biometrics. 1988 Jun;44(2):417-31 [3390507] Breast Cancer Res Treat. 1989 Jan;13(1):61-9 [2495831] Fundam Appl Toxicol. 1989 May;12(4):731-7 [2744275] Proc Natl Acad Sci U S A. 1989 Oct;86(19):7505-9 [2798421] Anticancer Res. 1990 Mar-Apr;10(2A):337-42 [2189360] Acta Anat (Basel). 1991;140(2):97-103 [1867061] Environ Mol Mutagen. 1992;19 Suppl 21:2-141 [1541260] Cancer Res. 1992 May 15;52(10):2977-9 [1316232] Environ Mol Mutagen. 1993;21(2):160-79 [8444144] Carcinogenesis. 1995 Jun;16(6):1329-33 [7788850] Carcinogenesis. 1995 Dec;16(12):2893-8 [8603461] Toxicol Pathol. 1995 Sep-Oct;23(5):591-605 [8578102] Fundam Appl Toxicol. 1996 Jul;32(1):102-8 [8812243] Toxicol Pathol. 1998 May-Jun;26(3):428-41 [9608650] Crit Rev Toxicol. 1999 Mar;29(2):169-261 [10213111] JAMA. 1999 Jun 2;281(21):2020-8 [10359391] Curr Opin Pharmacol. 2004 Dec;4(6):614-20 [15525553] J Clin Endocrinol Metab. 2004 Dec;89(12):6235-8 [15579782] J Clin Endocrinol Metab. 2005 Feb;90(2):855-63 [15522925] Hum Reprod Update. 2005 Jul-Aug;11(4):411-23 [15817524] Gynakol Geburtshilfliche Rundsch. 2008;48(1):9-15 [18209494] Br J Pharmacol. 2008 Jun;154(3):502-21 [18500378] Apoptosis. 2008 Aug;13(8):959-71 [18543106] J Steroid Biochem Mol Biol. 2008 Jul;111(1-2):80-6 [18556192] Natl Toxicol Program Tech Rep Ser. 2010 Sep;(560):1, 7-31,33-171 passim [21037592] JAMA. 2000 Feb 9;283(6):779-82 [10683057] Environ Mol Mutagen. 2000;36(3):163-94 [11044899] Arch Intern Med. 2000 Nov 13;160(20):3093-104 [11074738] Fertil Steril. 2002 Apr;77 Suppl 4:S11-8 [12007897] J Clin Endocrinol Metab. 2002 Dec;87(12):5449-54 [12466335] Br J Sports Med. 2003 Jun;37(3):212-8 [12782545] FEMS Immunol Med Microbiol. 2003 Aug 18;38(1):13-22 [12900050] Horm Metab Res. 2004 Jan;36(1):62-6 [14983409] Rep Carcinog. 2002;10:116-9 [15323057] Am J Hematol. 2004 Nov;77(3):257-67 [15495253] Am J Anat. 1965 Nov;117(3):417-31 [4160088] J Anat. 1971 Jan;108(Pt 1):159-68 [4322581] Biometrics. 1971 Mar;27(1):103-17 [5547548] Biometrics. 1972 Jun;28(2):519-31 [5037867] Biometrics. 1977 Jun;33(2):386-9 [884197] Int Rev Cytol. 1977;50:333-96 [332658] Cell Tissue Res. 1978 Nov 20;194(2):269-77 [728964] Biol Reprod. 1979 Sep;21(2):455-63 [486667] Mutat Res. 1981 Mar;91(2):93-8 [7019696] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fct.2011.05.026 ER - TY - JOUR T1 - A pilot analytic study of a research-level, lower-cost human papillomavirus 16, 18, and 45 test. AN - 879103970; 21640138 AB - The analytic performance of a low-cost, research-stage DNA test for the most carcinogenic human papillomavirus (HPV) genotypes (HPV16, HPV18, and HPV45) in aggregate was evaluated among carcinogenic HPV-positive women, which might be used to decide who needs immediate colposcopy in low-resource settings ("triage test"). We found that HPV16/18/45 test agreed well with two DNA tests, a GP5+/6+ genotyping assay (Kappa = 0.77) and a quantitative PCR assay (at a cutpoint of 5000 viral copies) (Kappa = 0.87). DNA sequencing on a subset of 16 HPV16/18/45 positive and 16 HPV16/18/45 negative verified the analytic specificity of the research test. It is concluded that the HPV16/18/45 assay is a promising triage test with a minimum detection of approximately 5000 viral copies, the clinically relevant threshold. Published by Elsevier B.V. JF - Journal of virological methods AU - Yang, Hannah P AU - Walmer, David K AU - Merisier, Delson AU - Gage, Julia C AU - Bell, Laura AU - Rangwala, Sameera AU - Shrestha, Niwashin AU - Kobayashi, Lori AU - Eder, Paul S AU - Castle, Philip E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892-7234, USA. yanghan@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 112 EP - 114 VL - 176 IS - 1-2 KW - DNA, Viral KW - 0 KW - Index Medicus KW - DNA, Viral -- analysis KW - Humans KW - Cervix Uteri -- virology KW - Pilot Projects KW - Female KW - Colposcopy KW - Human papillomavirus 18 -- genetics KW - Human papillomavirus 16 -- isolation & purification KW - Human papillomavirus 18 -- classification KW - Polymerase Chain Reaction -- methods KW - Papillomavirus Infections -- virology KW - Human papillomavirus 18 -- isolation & purification KW - Cervical Intraepithelial Neoplasia -- virology KW - Human papillomavirus 16 -- genetics KW - Uterine Cervical Neoplasms -- virology KW - Human papillomavirus 16 -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879103970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virological+methods&rft.atitle=A+pilot+analytic+study+of+a+research-level%2C+lower-cost+human+papillomavirus+16%2C+18%2C+and+45+test.&rft.au=Yang%2C+Hannah+P%3BWalmer%2C+David+K%3BMerisier%2C+Delson%3BGage%2C+Julia+C%3BBell%2C+Laura%3BRangwala%2C+Sameera%3BShrestha%2C+Niwashin%3BKobayashi%2C+Lori%3BEder%2C+Paul+S%3BCastle%2C+Philip+E&rft.aulast=Yang&rft.aufirst=Hannah&rft.date=2011-09-01&rft.volume=176&rft.issue=1-2&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Journal+of+virological+methods&rft.issn=1879-0984&rft_id=info:doi/10.1016%2Fj.jviromet.2011.05.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-21 N1 - Date created - 2011-07-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Microbiol. 2002 Mar;40(3):902-7 [11880413] J Natl Cancer Inst. 2010 Oct 20;102(20):1557-67 [20884893] J Natl Cancer Inst. 2003 Mar 19;95(6):E2 [12644550] J Gen Virol. 1995 Apr;76 ( Pt 4):1057-62 [9049358] J Clin Microbiol. 1999 Mar;37(3):796-7 [9986857] Gynecol Oncol. 2005 Jul;98(1):84-91 [15894364] J Natl Cancer Inst. 2005 Jul 20;97(14):1072-9 [16030305] Lancet. 2005 Sep 17-23;366(9490):991-8 [16168781] Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1268-73 [16835322] Br J Cancer. 2007 May 7;96(9):1419-24 [17342094] Lancet Infect Dis. 2007 Jul;7(7):453-9 [17597569] Vaccine. 2008 Aug 19;26 Suppl 10:K29-41 [18847555] J Virol Methods. 2008 Dec;154(1-2):76-81 [18835300] Lancet Oncol. 2008 Oct;9(10):929-36 [18805733] J Clin Virol. 2009 Jul;45 Suppl 1:S3-S12 [19651367] J Natl Cancer Inst. 2010 Oct 20;102(20):1524-7 [20884892] N Engl J Med. 2003 Feb 6;348(6):518-27 [12571259] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jviromet.2011.05.024 ER - TY - JOUR T1 - Activation and regulation of purinergic P2X receptor channels. AN - 878596349; 21737531 AB - Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two transmembrane domains, and intracellular N and C termini. Functional P2XRs are organized as homomeric and heteromeric trimers. This review focuses on the binding sites involved in the activation (orthosteric) and regulation (allosteric) of P2XRs. The ectodomains contain three ATP binding sites, presumably located between neighboring subunits and formed by highly conserved residues. The detection and coordination of three ATP phosphate residues by positively charged amino acids are likely to play a dominant role in determining agonist potency, whereas an AsnPheArg motif may contribute to binding by coordinating the adenine ring. Nonconserved ectodomain histidines provide the binding sites for trace metals, divalent cations, and protons. The transmembrane domains account not only for the formation of the channel pore but also for the binding of ivermectin (a specific P2X4R allosteric regulator) and alcohols. The N- and C- domains provide the structures that determine the kinetics of receptor desensitization and/or pore dilation and are critical for the regulation of receptor functions by intracellular messengers, kinases, reactive oxygen species and mercury. The recent publication of the crystal structure of the zebrafish P2X4.1R in a closed state provides a major advance in the understanding of this family of receptor channels. We will discuss data obtained from numerous site-directed mutagenesis experiments accumulated during the last 15 years with reference to the crystal structure, allowing a structural interpretation of the molecular basis of orthosteric and allosteric ligand actions. JF - Pharmacological reviews AU - Coddou, Claudio AU - Yan, Zonghe AU - Obsil, Tomas AU - Huidobro-Toro, J Pablo AU - Stojilkovic, Stanko S AD - Section on Cellular Signaling, Program in Developmental Neuroscience, National Institute of Child Health and Human Developmant, National Institutes of Health, Bethesda, MD 20892-4510, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 641 EP - 683 VL - 63 IS - 3 KW - Metals KW - 0 KW - Nerve Tissue Proteins KW - Protein Isoforms KW - Purinergic P2X Receptor Agonists KW - Purinergic P2X Receptor Antagonists KW - Receptors, Purinergic P2X KW - Index Medicus KW - Protein Isoforms -- agonists KW - Animals KW - Metals -- pharmacology KW - Protein Isoforms -- chemistry KW - Protein Isoforms -- metabolism KW - Humans KW - Protein Isoforms -- antagonists & inhibitors KW - Protein Conformation KW - Metals -- toxicity KW - Binding Sites KW - Receptors, Purinergic P2X -- genetics KW - Receptors, Purinergic P2X -- metabolism KW - Receptors, Purinergic P2X -- chemistry KW - Nerve Tissue Proteins -- metabolism KW - Nerve Tissue Proteins -- genetics KW - Nerve Tissue Proteins -- chemistry KW - Purinergic P2X Receptor Antagonists -- pharmacology KW - Purinergic P2X Receptor Agonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878596349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacological+reviews&rft.atitle=Activation+and+regulation+of+purinergic+P2X+receptor+channels.&rft.au=Coddou%2C+Claudio%3BYan%2C+Zonghe%3BObsil%2C+Tomas%3BHuidobro-Toro%2C+J+Pablo%3BStojilkovic%2C+Stanko+S&rft.aulast=Coddou&rft.aufirst=Claudio&rft.date=2011-09-01&rft.volume=63&rft.issue=3&rft.spage=641&rft.isbn=&rft.btitle=&rft.title=Pharmacological+reviews&rft.issn=1521-0081&rft_id=info:doi/10.1124%2Fpr.110.003129 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-25 N1 - Date created - 2011-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 2002 Jul 26;295(4):849-53 [12127972] J Gen Physiol. 2002 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2004;240:31-304 [15548415] Toxicol Appl Pharmacol. 2005 Jan 15;202(2):121-31 [15629187] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/pr.110.003129 ER - TY - JOUR T1 - Effects of 5,6-benzoflavone, indole-3-carbinol (I3C) and diindolylmethane (DIM) on chemically-induced mammary carcinogenesis: is DIM a substitute for I3C? AN - 874900474; 21617870 AB - The abilities of 5,6-benzoflavone (5,6-BF, a synthetic flavonoid), indole-3-carbinol (I3C, a plant derived product) or diindolylmethane (DIM, a condensation product of I3C) to alter the induction of mammary cancers induced by the carcinogens 7,12-dimethylbenzanthracene (DMBA) or N-methyl-N-nitrosourea (MNU) were evaluated. Interestingly, the first two agents act as aryl hydrocarbon receptor (AhR) agonists, while DIM does not. The agents were initially examined for their ability to inhibit DMBA-induced mammary carcinogenesis. Agents were administered for 14 days starting 7 days prior to a single dose of the carcinogen. Evaluated over an extensive range of doses (165, 550 and 1650 ppm in the diet), 5,6-BF caused a dose-dependent decrease of mammary cancers. In addition, 5,6-BF at doses of 1650 and 165 ppm in the diet blocked the induction of DMBA-induced DNA adducts in the mammary gland by approximately 85% and 45%, respectively. In contrast, DIM (180 or 20 mg/kg BW/day) failed to block induction of DMBA tumors. The effect of these agents on the promotion/progression phase of carcinogenesis using the MNU mammary cancer model was also determined. 5,6-BF (1650 or 165 ppm in the diet), I3C (180 or 60 mg/kg BW/day administered by gavage), or DIM (180 or 60 mg/kg BW/day by gavage) were initiated 5 days after the administration of MNU, and continually thereafter. 5,6-BF decreased MNU- induced mammary tumor multiplicity by 40-60%. I3C reduced tumor multiplicity at the high dose, while DIM at either dose had minimal effects on tumor multiplicity. Thus, 5,6-BF and I3C were highly effective against initiation of DMBA-induced mammary carcinogenesis, and were also effective against MNU-induced tumors during the promotion/progression phase of carcinogenesis. In contrast, DIM had minimal effects in either model; arguing that administration of DIM is not analogous to administration of I3C. JF - Oncology reports AU - Lubet, Ronald A AU - Heckman, Brandy M AU - De Flora, Silvio L AU - Steele, Vernon E AU - Crowell, James A AU - Juliana, M Margaret AU - Grubbs, Clinton J AD - Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Suite 2110, NIH, NCI, 9000 Rockville Pike, Bethesda, MD 20892, USA. lubetr@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 731 EP - 736 VL - 26 IS - 3 KW - Anticarcinogenic Agents KW - 0 KW - Indoles KW - diindolylmethane KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - beta-Naphthoflavone KW - 6051-87-2 KW - Methylnitrosourea KW - 684-93-5 KW - indole-3-carbinol KW - C11E72455F KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Cyp1b1 protein, rat KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP1B1 KW - Index Medicus KW - Animals KW - Cytochrome P-450 CYP1A1 -- genetics KW - Mammary Glands, Animal -- drug effects KW - Tumor Burden KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Transcription, Genetic KW - Rats KW - Rats, Sprague-Dawley KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Epithelial Cells -- drug effects KW - Epithelial Cells -- pathology KW - Mammary Glands, Animal -- pathology KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Female KW - Mammary Neoplasms, Experimental -- chemically induced KW - Anticarcinogenic Agents -- pharmacology KW - beta-Naphthoflavone -- pharmacology KW - Indoles -- pharmacology KW - Mammary Neoplasms, Experimental -- prevention & control KW - Mammary Neoplasms, Experimental -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874900474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+reports&rft.atitle=Effects+of+5%2C6-benzoflavone%2C+indole-3-carbinol+%28I3C%29+and+diindolylmethane+%28DIM%29+on+chemically-induced+mammary+carcinogenesis%3A+is+DIM+a+substitute+for+I3C%3F&rft.au=Lubet%2C+Ronald+A%3BHeckman%2C+Brandy+M%3BDe+Flora%2C+Silvio+L%3BSteele%2C+Vernon+E%3BCrowell%2C+James+A%3BJuliana%2C+M+Margaret%3BGrubbs%2C+Clinton+J&rft.aulast=Lubet&rft.aufirst=Ronald&rft.date=2011-09-01&rft.volume=26&rft.issue=3&rft.spage=731&rft.isbn=&rft.btitle=&rft.title=Oncology+reports&rft.issn=1791-2431&rft_id=info:doi/10.3892%2For.2011.1316 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-24 N1 - Date created - 2011-07-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3892/or.2011.1316 ER - TY - JOUR T1 - HDAC inhibitor vorinostat enhances the antitumor effect of gefitinib in squamous cell carcinoma of head and neck by modulating ErbB receptor expression and reverting EMT. AN - 871389260; 21660961 AB - Potentiation of epidermal growth factor receptor (EGFR) inhibitors is required in squamous cell carcinoma of head and neck (SCCHN) to improve their therapeutic index. We demonstrated that the histone deacetylase inhibitor vorinostat in combination with the EGFR tyrosine kinase inhibitor gefitinib induced synergistic inhibition of proliferation, migration, and invasion as well as induction of apoptosis in SCCHN cells, including cells resistant to gefitinib. We provided evidence suggesting that differential modulation of ErbB receptors together with reversion of epithelial-to-mesenchymal transition (EMT) by vorinostat represent mechanistic bases for the observed synergism. We demonstrated in epithelial CAL27 cells expressing EGFR, ErbB2, and ErbB3 that vorinostat downregulated the expression and signaling of all three receptors. In gefitinib-resistant KB and Hep-2 cells, both of which had undergone EMT and expressed very low levels of ErbB3, vorinostat reverted the mesenchymal phenotype by inducing both E-cadherin and ErbB3 and downregulating vimentin as well as EGFR and ErbB2. Both transcriptional and post-translational mechanisms were involved in the modulation of ErbB receptors by vorinostat. Attenuation of all ErbB transcripts in CAL27 cells as well as induction of ErbB3 transcript in Hep-2 and KB cells was seen upon vorinostat treatment. We showed that vorinostat induced ubiquitination of EGFR and ErbB2 and targeted them predominantly to lysosome-degradation in all cell lines, while the induction of ErbB3-ubiquitination in CAL27 cells led to proteasomes-degradation. Overall, this study suggests that the vorinostat/gefitinib combination represents a promising therapeutic strategy that warrants further clinical evaluation in SCCHN, including tumors intrinsically resistant to EGFR-inhibitors. Copyright © 2010 Wiley-Liss, Inc. JF - Journal of cellular physiology AU - Bruzzese, Francesca AU - Leone, Alessandra AU - Rocco, Monia AU - Carbone, Carmine AU - Piro, Geny AU - Caraglia, Michele AU - Di Gennaro, Elena AU - Budillon, Alfredo AD - Experimental Pharmacology Unit, Department of Research, National Cancer Institute Fondazione G Pascale, Naples, Italy. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 2378 EP - 2390 VL - 226 IS - 9 KW - Biomarkers, Tumor KW - 0 KW - Histone Deacetylase Inhibitors KW - Hydroxamic Acids KW - Quinazolines KW - RNA, Messenger KW - vorinostat KW - 58IFB293JI KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Receptor, ErbB-2 KW - Receptor, ErbB-3 KW - gefitinib KW - S65743JHBS KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Drug Screening Assays, Antitumor KW - Receptor, Epidermal Growth Factor -- metabolism KW - Histone Deacetylase Inhibitors -- pharmacology KW - Humans KW - Cell Line, Tumor KW - RNA, Messenger -- genetics KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Biomarkers, Tumor -- metabolism KW - Receptor, Epidermal Growth Factor -- genetics KW - RNA, Messenger -- metabolism KW - Ubiquitination -- drug effects KW - Cell Movement -- drug effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Drug Synergism KW - Receptor, ErbB-2 -- genetics KW - Receptor, ErbB-3 -- metabolism KW - Receptor, ErbB-2 -- metabolism KW - Carcinoma, Squamous Cell -- pathology KW - Receptor, ErbB-3 -- genetics KW - Carcinoma, Squamous Cell -- genetics KW - Head and Neck Neoplasms -- pathology KW - Epithelial-Mesenchymal Transition -- drug effects KW - Head and Neck Neoplasms -- genetics KW - Hydroxamic Acids -- pharmacology KW - Head and Neck Neoplasms -- drug therapy KW - Carcinoma, Squamous Cell -- drug therapy KW - Quinazolines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/871389260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+physiology&rft.atitle=HDAC+inhibitor+vorinostat+enhances+the+antitumor+effect+of+gefitinib+in+squamous+cell+carcinoma+of+head+and+neck+by+modulating+ErbB+receptor+expression+and+reverting+EMT.&rft.au=Bruzzese%2C+Francesca%3BLeone%2C+Alessandra%3BRocco%2C+Monia%3BCarbone%2C+Carmine%3BPiro%2C+Geny%3BCaraglia%2C+Michele%3BDi+Gennaro%2C+Elena%3BBudillon%2C+Alfredo&rft.aulast=Bruzzese&rft.aufirst=Francesca&rft.date=2011-09-01&rft.volume=226&rft.issue=9&rft.spage=2378&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+physiology&rft.issn=1097-4652&rft_id=info:doi/10.1002%2Fjcp.22574 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-17 N1 - Date created - 2011-06-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jcp.22574 ER - TY - JOUR T1 - Hospitalizations for Alcohol and Drug Overdoses in Young Adults Ages 18-24 in the United States, 1999-2008: Results From the Nationwide Inpatient Sample AN - 1823506460; 201121061 AB - Objective: Recent reports indicate an increase in rates of hospitalizations for drug overdoses in the United States. The role of alcohol in hospitalizations for drug overdoses remains unclear. Excessive consumption of alcohol and drugs is prevalent in young adults ages 18-24. The present study explores rates and costs of inpatient hospital stays for alcohol overdoses, drug overdoses, and their co-occurrence in young adults ages 18-24 and changes in these rates between 1999 and 2008. Method: Data from the Nationwide Inpatient Sample were used to estimate numbers, rates, and costs of inpatient hospital stays stemming from alcohol overdoses (and their subcategories, alcohol poisonings and excessive consumption of alcohol), drug overdoses (and their subcategories, drug poisonings and nondependent abuse of drugs), and their co-occurrence in 18- to 24-year-olds. Results: Hospitalization rates for alcohol overdoses alone increased 25% from 1999 to 2008, reaching 29,412 cases in 2008 at a cost of $266 million. Hospitalization rates for drug overdoses alone increased 55%, totaling 113,907 cases in 2008 at a cost of $737 million. Hospitalization rates for combined alcohol and drug overdoses increased 76%, with 29,202 cases in 2008 at a cost of $198 million. Conclusions: Rates of hospitalizations for alcohol overdoses, drug overdoses, and their combination all increased from 1999 to 2008 among 18- to 24-year-olds. The cost of such hospitalizations now exceeds $1.2 billion annually. The steepest increase occurred among cases of combined alcohol and drug overdoses. Stronger efforts are needed to educate medical practitioners and the public about the risk of overdoses, particularly when alcohol is combined with other drugs. Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - White, Aaron M AU - Hingson, Ralph W AU - Pan, I-Jen AU - Yi, Hsiao-Ye AD - Division of Epidemiology and Prevention Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, MSC 9304, Room 2074, Bethesda, Maryland 20892-9304 whitea4@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 774 EP - 786 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 72 IS - 5 SN - 1937-1888, 1937-1888 KW - Alcohol consumption KW - Hospitalization KW - Poisoning KW - Young adults KW - Overdoses KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1823506460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=Hospitalizations+for+Alcohol+and+Drug+Overdoses+in+Young+Adults+Ages+18-24+in+the+United+States%2C+1999-2008%3A+Results+From+the+Nationwide+Inpatient+Sample&rft.au=White%2C+Aaron+M%3BHingson%2C+Ralph+W%3BPan%2C+I-Jen%3BYi%2C+Hsiao-Ye&rft.aulast=White&rft.aufirst=Aaron&rft.date=2011-09-01&rft.volume=72&rft.issue=5&rft.spage=774&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Overdoses; Hospitalization; Young adults; Alcohol consumption; Hospitals; Poisoning ER - TY - JOUR T1 - Q sub( gamma -H2AX), an analysis method for partial-body radiation exposure using gamma -H2AX in non-human primate lymphocytes AN - 1744672939; 15744657 AB - We previously used the gamma -H2AX assay as a biodosimeter for total-body irradiation (TBI) exposure ( gamma -rays) in a rhesus macaque (Macaca mulatta) model. Utilizing peripheral blood lymphocytes and plucked hairs, we obtained statistically significant gamma -H2AX responses days after total-body exposure to 1-8.5 Gy ( super(60)Co gamma -rays at 55 cGy min super(-1)). Here, we introduce a partial-body exposure analysis method, Q sub( gamma -H2AX), which is based on the number of gamma -H2AX foci per damaged cells as evident by having one or more gamma -H2AX foci per cell. Results from the rhesus monkey - TBI study were used to establish Q sub( gamma -H2AX) dose-response calibration curves to assess acute partial-body exposures. gamma -H2AX foci were detected in plucked hairs for several days after in vivo irradiation demonstrating this assay's utility for dose assessment in various body regions. The quantitation of gamma -H2AX may provide a robust biodosimeter for analyzing partial-body exposures to ionizing radiation in humans. JF - Radiation Measurements AU - Redon, Christophe E AU - Nakamura, Asako J AU - Gouliaeva, Ksenia AU - Rahman, Arifur AU - Blakely, William F AU - Bonner, William M Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 877 EP - 881 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 46 IS - 9 SN - 1350-4487, 1350-4487 KW - Solid State and Superconductivity Abstracts (SO); Advanced Polymers Abstracts (EP); Environmental Engineering Abstracts (EN); Composites Industry Abstracts (ED); Engineered Materials Abstracts, Ceramics (EC) KW - Biological dosimetry KW - gamma -H2AX KW - Q gamma -H2AX KW - F gamma -H2AX KW - Rhesus macaque (Macaca mulatta) KW - Lymphocytes KW - 60Co gamma -rays KW - Ionizing radiation KW - Partial-body exposure KW - Assaying KW - Monkeys KW - Assessments KW - Surgical implants KW - Irradiation KW - Hair UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1744672939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Measurements&rft.atitle=Q+sub%28+gamma+-H2AX%29%2C+an+analysis+method+for+partial-body+radiation+exposure+using+gamma+-H2AX+in+non-human+primate+lymphocytes&rft.au=Redon%2C+Christophe+E%3BNakamura%2C+Asako+J%3BGouliaeva%2C+Ksenia%3BRahman%2C+Arifur%3BBlakely%2C+William+F%3BBonner%2C+William+M&rft.aulast=Redon&rft.aufirst=Christophe&rft.date=2011-09-01&rft.volume=46&rft.issue=9&rft.spage=877&rft.isbn=&rft.btitle=&rft.title=Radiation+Measurements&rft.issn=13504487&rft_id=info:doi/10.1016%2Fj.radmeas.2011.02.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1016/j.radmeas.2011.02.017 ER - TY - JOUR T1 - Lung imaging in asthmatic patients: The picture is clearer AN - 1514896743; 21636118 AB - Imaging of the lungs in patients with asthma has evolved dramatically over the last decade with sophisticated techniques, such as computed tomography, magnetic resonance imaging, positron emission tomography, and single photon emission computed tomography. New insights into current and future modalities for imaging in asthmatic patients and their application are discussed to potentially shed a clearer picture of the underlying pathophysiology of asthma, especially severe asthma, and the proposed clinical utility of imaging in patients with this common disease. JF - Journal of Allergy and Clinical Immunology AU - Castro, Mario AU - Fain, Sean B AU - Hoffman, Eric A AU - Gierada, David S AU - Erzurum, Serpil C AU - Wenzel, Sally Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 467 EP - 78 CY - St. Louis PB - Elsevier Science Ltd. VL - 128 IS - 3 SN - 00916749 KW - Abstracting And Indexing Services KW - Asthma KW - Studies KW - Medical imaging KW - Anatomy & physiology KW - Ventilation KW - Lungs KW - Algorithms KW - Trees KW - Dimensional analysis KW - Magnetic Resonance Imaging KW - Tomography, Emission-Computed, Single-Photon KW - Positron-Emission Tomography KW - Humans KW - Tomography, X-Ray Computed KW - Asthma -- physiopathology KW - Asthma -- radiography KW - Lung -- radiography KW - Diagnostic Imaging -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1514896743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=Lung+imaging+in+asthmatic+patients%3A+The+picture+is+clearer&rft.au=Castro%2C+Mario%3BFain%2C+Sean+B%3BHoffman%2C+Eric+A%3BGierada%2C+David+S%3BErzurum%2C+Serpil+C%3BWenzel%2C+Sally&rft.aulast=Castro&rft.aufirst=Mario&rft.date=2011-09-01&rft.volume=128&rft.issue=3&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/10.1016%2Fj.jaci.2011.04.051 LA - English DB - ProQuest Central N1 - Copyright - Copyright Elsevier Limited Sep 2011 N1 - Last updated - 2014-09-26 DO - http://dx.doi.org/10.1016/j.jaci.2011.04.051 ER - TY - JOUR T1 - Two-stage sector sampling for estimating small woodlot attributes AN - 1032895837; 16957564 AB - A two-stage sampling strategy is proposed to assess small woodlots outside the forests scattered on extensive territories. The first stage is performed to select a sample of small woodlots using fixed-size sampling schemes, and the second stage is performed to sample trees within woodlots selected at first stage. Usually, fixed- or variable-area plots are adopted to sample trees. However, the use of plot sampling in small patches such as woodlots is likely to induce a relevant amount of bias owing to edge effects. In this framework, sector sampling proves to be particularly effective. The present paper investigates the statistical properties of two-stage sampling strategies for estimating forest attributes of woodlot populations when sector sampling is adopted at the second stage. A two-stage estimator of population totals is derived together with a conservative estimator of its sampling variance. By means of a simulation study, the performance of the proposed estimator is checked and compared with that achieved using traditional plot sampling with edge corrections. Simulation results prove the adequacy of sector sampling and provide some guidelines for the effective planning of the strategy. In some countries, the proposed strategy can be performed with few modifications within the framework of large-scale forest inventories.Original Abstract: Une strategie d'echantillonnage en deux etapes est proposee pour evaluer les petits boises situes a l'ecart des forets et disperses sur de vastes territoires. La premiere etape sert a selectionner un echantillon de petits boises en utilisant des plans d'echantillonnage a surface fixe tandis que la deuxieme etape sert a echantillonner les arbres dans les boises selectionnes lors de la premiere etape. Habituellement, des placettes a surface fixe ou variable sont utilisees pour echantillonner les arbres. Cependant, l'utilisation de placettes dans de petits boises est susceptible d'induire un biais appreciable du a l'effet de bordure. Dans ce cas, l'echantillonnage par secteur se revele particulierement efficace. Le present article etudie les proprietes statistiques des strategies d'echantillonnage en deux etapes pour estimer les attributs forestiers de populations de boises lorsque l'echantillonnage par secteur est utilise lors de la deuxieme etape. Un estimateur en deux etapes des totaux de population est derive avec un estimateur conservateur de sa variance d'echantillonnage. La performance de l'estimateur propose est verifiee et comparee par simulation avec celle obtenue par l'echantillonnage traditionnel accompagne d'une correction pour tenir compte de l'effet de bordure. Les resultats de la simulation demontrent que l'echantillonnage par secteur est adequat et fournissent des lignes directrices pour la planification efficace de la strategie d'echantillonnage. Dans certains pays, la strategie proposee peut etre realisee avec peu de modifications dans le cadre de l'inventaire forestier a grande echelle. JF - Canadian Journal of Forest Research/Revue Canadienne de Recherche Forestiere AU - Corona, Piermaria AU - Fattorini, Lorenzo AU - Franceschi, Sara AD - Dipartimento per l'Innovazione nei Sistemi Biologici, Agroalimentari e Forestali (DIBAF), Universita della Tuscia, via San Camillo de Lellis, 01100 Viterbo, Italy., fattorini@unisi.it Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1819 EP - 1826 PB - NRC Research Press VL - 41 IS - 9 SN - 0045-5067, 0045-5067 KW - Environment Abstracts; Sustainability Science Abstracts; Ecology Abstracts KW - Inventories KW - Statistics KW - Trees KW - Guidelines KW - Simulation KW - Forests KW - Territory KW - Edge effect KW - Sampling KW - ENA 13:Population Planning & Control KW - M3 1010:Issues in Sustainable Development KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1032895837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Canadian+Journal+of+Forest+Research%2FRevue+Canadienne+de+Recherche+Forestiere&rft.atitle=Two-stage+sector+sampling+for+estimating+small+woodlot+attributes&rft.au=Corona%2C+Piermaria%3BFattorini%2C+Lorenzo%3BFranceschi%2C+Sara&rft.aulast=Corona&rft.aufirst=Piermaria&rft.date=2011-09-01&rft.volume=41&rft.issue=9&rft.spage=1819&rft.isbn=&rft.btitle=&rft.title=Canadian+Journal+of+Forest+Research%2FRevue+Canadienne+de+Recherche+Forestiere&rft.issn=00455067&rft_id=info:doi/10.1139%2Fx11-101 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Number of references - 19 N1 - Last updated - 2015-05-27 N1 - SubjectsTermNotLitGenreText - Inventories; Statistics; Trees; Forests; Territory; Sampling; Edge effect; Guidelines; Simulation DO - http://dx.doi.org/10.1139/x11-101 ER - TY - JOUR T1 - Optimal estimating functions in incomplete data and length biased sampling data problems AN - 1031278449; 4317939 AB - It is well known that the score function is the optimal estimating function among all regular unbiased estimating functions (Godambe, 1960). In the presence of incomplete data such as missing data or length biased sampling data, Horvitz and Thompson's (1952) method is an effective way of eliminating the possible bias induced by using complete data only. In this article, we show that the inverse weighted Horvitz and Thompson score estimating function is not optimal in the presence of incomplete data. By using Godambe's estimating function theory, we can identify the optimal estimating function in this situation. In the case of the accelerated failure time model with length bias sampling data, the optimal estimating function can produce an unbiased estimator for the slope parameter even when the underlying density function is misspecified. Simulation studies show that the estimate derived from the optimal estimating function can be substantially better than the estimate derived from the inverse weighted score estimating function. JF - Canadian journal of statistics AU - Zhang, Biao AU - Qin, Jing AD - National Institute of Allergy and Infectious Diseases, USA Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 510 EP - 518 VL - 39 IS - 3 SN - 0319-5724, 0319-5724 KW - Economics KW - Godambe estimating function KW - Score functions KW - Simulation KW - Estimation KW - Sampling KW - Data analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1031278449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Canadian+journal+of+statistics&rft.atitle=Optimal+estimating+functions+in+incomplete+data+and+length+biased+sampling+data+problems&rft.au=Zhang%2C+Biao%3BQin%2C+Jing&rft.aulast=Zhang&rft.aufirst=Biao&rft.date=2011-09-01&rft.volume=39&rft.issue=3&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=Canadian+journal+of+statistics&rft.issn=03195724&rft_id=info:doi/10.1002%2Fcjs LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11255 12228 10919; 4403 7854; 11670; 3279 971 3286 DO - http://dx.doi.org/10.1002/cjs ER - TY - JOUR T1 - An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies AN - 1020847950; 15397675 AB - Background: Greater tobacco smoking and alcohol consumption and lower body mass index (BMI) increase odds ratios (OR) for oral cavity, oropharyngeal, hypopharyngeal, and laryngeal cancers; however, there are no comprehensive sex-specific comparisons of ORs for these factors. Methods: We analyzed 2,441 oral cavity (925 women and 1,516 men), 2,297 oropharynx (564 women and 1,733 men), 508 hypopharynx (96 women and 412 men), and 1,740 larynx (237 women and 1,503 men) cases from the INHANCE consortium of 15 head and neck cancer case-control studies. Controls numbered from 7,604 to 13,829 subjects, depending on analysis. Analyses fitted linear-exponential excess ORs models. Results: ORs were increased in underweight (<18.5 BMI) relative to normal weight (18.5-24.9) and reduced in overweight and obese categories ( greater than or equal to 25 BMI) for all sites and were homogeneous by sex. ORs by smoking and drinking in women compared with men were significantly greater for oropharyngeal cancer (p < 0.01 for both factors), suggestive for hypopharyngeal cancer (p = 0.05 and p = 0.06, respectively), but homogeneous for oral cavity (p = 0.56 and p = 0.64) and laryngeal (p = 0.18 and p = 0.72) cancers. Conclusions: The extent that OR modifications of smoking and drinking by sex for oropharyngeal and, possibly, hypopharyngeal cancers represent true associations, or derive from unmeasured confounders or unobserved sex-related disease subtypes (e.g., human papillomavirus-positive oropharyngeal cancer) remains to be clarified. JF - Cancer Causes & Control AU - Lubin, Jay H AU - Muscat, Joshua AU - Gaudet, Mia M AU - Olshan, Andrew F AU - Curado, Maria Paula AU - Dal Maso, Luigino AU - Wunsch-Filho, Victor AU - Sturgis, Erich M AU - Szeszenia-Dabrowska, Neonilia AU - Castellsague, Xavier AU - Zhang, Zuo-Feng AU - Smith, Elaine AU - Fernandez, Leticia AU - Matos, Elena AU - Franceschi, Silvia AU - Fabianova, Eleonora AU - Rudnai, Peter AU - Purdue, Mark P AU - Mates, Dana AU - Wei, Qingyi AU - Herrero, Rolando AU - Kelsey, Karl AU - Morgenstern, Hal AU - Shangina, Oxana AU - Koifman, Sergio AU - Lissowska, Jolanta AU - Levi, Fabio AU - Daudt, Alexander W AU - Neto, Jose Eluf AU - Chen, Chu AU - Lazarus, Philip AU - Winn, Deborah M AU - Schwartz, Stephen M AU - Boffetta, Paolo AU - Brennan, Paul AU - Menezes, Ana AU - Vecchia, Carlo La AU - McClean, Michael AU - Talamini, Renato AU - Rajkumar, Thangarajan AU - Hayes, Richard B AU - Hashibe, Mia AD - Occupational Health Department, Institute of Public Health, Bucharest, Romania, lubinj@mail.nih.gov lubinj@mail.nih.gov lubinj@mail.nih.gov lubinj@mail.nih.gov lubinj@mail.nih.gov lubinj@mail.nih.gov lubinj@mail.nih.gov lubinj@mail.nih.gov lubinj@mail.nih.gov lubinj@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1217 EP - 1231 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 22 IS - 9 SN - 0957-5243, 0957-5243 KW - Physical Education Index KW - Smoking KW - Alcohol KW - Obesity KW - Men KW - Body mass KW - Analysis KW - Women KW - Tobacco KW - Cancer KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020847950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=An+examination+of+male+and+female+odds+ratios+by+BMI%2C+cigarette+smoking%2C+and+alcohol+consumption+for+cancers+of+the+oral+cavity%2C+pharynx%2C+and+larynx+in+pooled+data+from+15+case-control+studies&rft.au=Lubin%2C+Jay+H%3BMuscat%2C+Joshua%3BGaudet%2C+Mia+M%3BOlshan%2C+Andrew+F%3BCurado%2C+Maria+Paula%3BDal+Maso%2C+Luigino%3BWunsch-Filho%2C+Victor%3BSturgis%2C+Erich+M%3BSzeszenia-Dabrowska%2C+Neonilia%3BCastellsague%2C+Xavier%3BZhang%2C+Zuo-Feng%3BSmith%2C+Elaine%3BFernandez%2C+Leticia%3BMatos%2C+Elena%3BFranceschi%2C+Silvia%3BFabianova%2C+Eleonora%3BRudnai%2C+Peter%3BPurdue%2C+Mark+P%3BMates%2C+Dana%3BWei%2C+Qingyi%3BHerrero%2C+Rolando%3BKelsey%2C+Karl%3BMorgenstern%2C+Hal%3BShangina%2C+Oxana%3BKoifman%2C+Sergio%3BLissowska%2C+Jolanta%3BLevi%2C+Fabio%3BDaudt%2C+Alexander+W%3BNeto%2C+Jose+Eluf%3BChen%2C+Chu%3BLazarus%2C+Philip%3BWinn%2C+Deborah+M%3BSchwartz%2C+Stephen+M%3BBoffetta%2C+Paolo%3BBrennan%2C+Paul%3BMenezes%2C+Ana%3BVecchia%2C+Carlo+La%3BMcClean%2C+Michael%3BTalamini%2C+Renato%3BRajkumar%2C+Thangarajan%3BHayes%2C+Richard+B%3BHashibe%2C+Mia&rft.aulast=Lubin&rft.aufirst=Jay&rft.date=2011-09-01&rft.volume=22&rft.issue=9&rft.spage=1217&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9792-x LA - English DB - Physical Education Index N1 - Date revised - 2012-06-01 N1 - Last updated - 2013-08-23 N1 - SubjectsTermNotLitGenreText - Obesity; Alcohol; Smoking; Men; Analysis; Body mass; Women; Tobacco; Cancer DO - http://dx.doi.org/10.1007/s10552-011-9792-x ER - TY - JOUR T1 - Reduced Fear Memory and Anxiety-like Behavior in Mice Lacking Formylpeptide Receptor 1 AN - 1018375935; 201210644 AB - N-formylpeptide receptor 1 (FPR1) is a G protein-coupled receptor that mediates pro-inflammatory chemotactic responses by phagocytic leukocytes to N-formylpeptides produced by bacteria or mitochondria. Mice lacking Fpr1 (Fpr1 -/- mice) have increased susceptibility to challenge with certain bacteria. FPR1 is also a receptor for annexin-1, which mediates the anti-inflammatory effects of glucocorticoids as well as negative feedback by glucocorticoids of the hypothalamic-pituitary-adrenocortical axis. However, homeostatic functions of FPR1 in the neuroendocrine system have not previously been defined. Here we show that in systematic behavioral testing Fpr1 -/- mice exhibited increased exploratory activity, reduced anxiety-like behavior, and impaired fear memory, but normal spatial memory and learning capacity. Consistent with this, the homeostatic serum level of corticosterone in Fpr1 -/- mice was significantly lower compared with wild-type mice. The data implicate Fpr1 in modulation of anxiety-like behavior and fear memory by regulating glucocorticoid production. Adapted from the source document. JF - Behavior Genetics AU - Gao, Ji-Liang AU - Schneider, Erich H AU - Dimitrov, Eugene L AU - Haun, Forrest AU - Pham, Therese M AU - Mohammed, Abdul H AU - Usdin, Ted B AU - Murphy, Philip M AD - Molecular Signalling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N107, NIH, Bethesda, MD, 20892, USA jgao@niaid.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 724 EP - 733 PB - Springer Science+Business Media, Inc, New York, NY VL - 41 IS - 5 SN - 0001-8244, 0001-8244 KW - Bacteria KW - Animals KW - Learning KW - Memory KW - Negative feedback KW - Fear KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018375935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavior+Genetics&rft.atitle=Reduced+Fear+Memory+and+Anxiety-like+Behavior+in+Mice+Lacking+Formylpeptide+Receptor+1&rft.au=Gao%2C+Ji-Liang%3BSchneider%2C+Erich+H%3BDimitrov%2C+Eugene+L%3BHaun%2C+Forrest%3BPham%2C+Therese+M%3BMohammed%2C+Abdul+H%3BUsdin%2C+Ted+B%3BMurphy%2C+Philip+M&rft.aulast=Gao&rft.aufirst=Ji-Liang&rft.date=2011-09-01&rft.volume=41&rft.issue=5&rft.spage=724&rft.isbn=&rft.btitle=&rft.title=Behavior+Genetics&rft.issn=00018244&rft_id=info:doi/10.1007%2Fs10519-011-9467-0 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BHGHAT N1 - SubjectsTermNotLitGenreText - Animals; Memory; Fear; Bacteria; Negative feedback; Learning DO - http://dx.doi.org/10.1007/s10519-011-9467-0 ER - TY - JOUR T1 - Cancer nanotechnology research in the United States and China: cooperation to promote innovation AN - 1017978439; 16719795 AB - The application of nanotechnology to cancer research is a promising area for US-China cooperation. Cancer is a major public health burden in both countries, and progress in cancer nanotechnology research is increasing in several fields, including imaging, biomarker detection, and targeted drug delivery. The United States and China are international leaders in nanotechnology research, and have both launched national programs to support nanotechnology efforts in the recent past. The accelerating trend of co-authorship among US and Chinese nanotechnology researchers demonstrates that individual scientists already recognize the potential for cooperation, providing a strong platform for creating additional partnerships in pre-competitive research areas. Mechanisms that could help to enhance US-China cancer nanotechnology partnerships include: developing new programs for bi-directional training and exchange; convening workshops focused on specific scientific topics of high priority to both countries; and joint support of collaborative research projects by US and Chinese funders. In addition to the accelerating scientific progress, expanded cooperation will stimulate important dialog on regulatory, policy, and technical issues needed to lay the groundwork for US and Chinese scientists to move greater numbers of cancer nanotechnology applications into the clinic. WIREs Nanomed Nanobiotechnol 2011 3 441-448 DOI: 10.1002/wnan.149 For further resources related to this article, please visit the WIREs website JF - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology AU - Schneider, Julie A AU - Grodzinski, Piotr AU - Liang, Xing-Jie AD - National Cancer Institute (NCI), NIH, Embassy of the United States, Beijing, PR China, schneidj@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 441 EP - 448 PB - Wiley-Blackwell, Baffins Lane Chichester W. Sussex PO19 1UD United Kingdom VL - 3 IS - 5 SN - 1939-0041, 1939-0041 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Conferences KW - Cooperation KW - Computed tomography KW - biomarkers KW - Cancer KW - nanotechnology KW - Public health KW - Joints KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017978439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.atitle=Cancer+nanotechnology+research+in+the+United+States+and+China%3A+cooperation+to+promote+innovation&rft.au=Schneider%2C+Julie+A%3BGrodzinski%2C+Piotr%3BLiang%2C+Xing-Jie&rft.aulast=Schneider&rft.aufirst=Julie&rft.date=2011-09-01&rft.volume=3&rft.issue=5&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.issn=19390041&rft_id=info:doi/10.1002%2Fwnan.149 L2 - http://onlinelibrary.wiley.com/doi/10.1002/wnan.149/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Drug delivery; Conferences; Cooperation; Computed tomography; biomarkers; Cancer; Joints; Public health; nanotechnology DO - http://dx.doi.org/10.1002/wnan.149 ER - TY - JOUR T1 - Directions in Human-Animal Interaction Research: Child Development, Health, and Therapeutic Interventions AN - 1010708593; 201208253 AB - Research on human-animal interaction (HAI) is a relatively new field of inquiry for developmental scientists seeking to understand the potential role pets play in children's health and well-being. It has been documented that pets offer a source of emotional support to children. However, most studies focusing on how animals affect children's health are limited and stop short of providing answers to key developmental questions. Addressing this need, beginning in 2008, scientists at the Eunice Kennedy Shriver National Institute of Child Health and Human Development, in collaboration with the Waltham Centre for Pet Nutrition, a subsidiary of the Mars Corporation, convened two international conferences of researchers to review the current science on HAI. These groups crafted a research agenda aimed at looking at how animal interaction affects children and promotes optimal development. This article reviews the key themes emerging from the conferences, addresses the application of HAI to child health and development, and discusses the potential of HAI as an important field of inquiry for developmental scientists. Adapted from the source document. JF - Child Development Perspectives AU - Esposito, Layla AU - McCune, Sandra AU - Griffin, James A AU - Maholmes, Valerie AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 205 EP - 211 PB - Wiley Publishing, Malden, MA 02148 VL - 5 IS - 3 SN - 1750-8592, 1750-8592 KW - Animals KW - Human development KW - Pets KW - Medical research KW - Health KW - Children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010708593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Development+Perspectives&rft.atitle=Directions+in+Human-Animal+Interaction+Research%3A+Child+Development%2C+Health%2C+and+Therapeutic+Interventions&rft.au=Esposito%2C+Layla%3BMcCune%2C+Sandra%3BGriffin%2C+James+A%3BMaholmes%2C+Valerie&rft.aulast=Esposito&rft.aufirst=Layla&rft.date=2011-09-01&rft.volume=5&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Child+Development+Perspectives&rft.issn=17508592&rft_id=info:doi/10.1111%2Fj.1750-8606.2011.00175.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Health; Children; Medical research; Pets; Animals; Human development DO - http://dx.doi.org/10.1111/j.1750-8606.2011.00175.x ER - TY - JOUR T1 - Relationships Among Health Perceptions Vary Depending on Stage of Readiness for Colorectal Cancer Screening AN - 1010707446; 201208280 AB - Objective: We explored whether relationships among health perceptions differ depending on individuals' stage of readiness for colorectal cancer screening (CRCS). Methods: Data from the National Cancer Institute's Health Information National Trends Survey (HINTS) were used to stage adults over 50 years of age (N = 2324) using a modified version of the Precaution Adoption Process Model (PAPM) staging algorithm. Health perceptions examined included perceived risk of cancer, worry about cancer, fatalism, and beliefs about ambiguity of cancer prevention recommendations. Results: Meaningful differences in patterns of relationships among health perceptions by stage were found. Conclusions: The nonlinear patterns that emerged indicate support for the role of these health perceptions in screening, the idea that behavioral readiness may moderate the relationship between important health perceptions, and the use of the stage construct in this context. [Copyright The American Psychological Association.] JF - Health Psychology AU - Ferrer, Rebecca A AU - Hall, Kara L AU - Portnoy, David B AU - Ling, Bruce S AU - Han, Paul K.J. AU - Klein, William M.P. AD - Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland ferrerra@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 525 EP - 535 PB - American Psychological Association, Washington DC VL - 30 IS - 5 SN - 0278-6133, 0278-6133 KW - health perceptions stage of readiness risk perceptions worry ambiguity fatalism KW - Screening KW - Perceptions KW - Readiness KW - Colorectal cancer KW - Health KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010707446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Psychology&rft.atitle=Relationships+Among+Health+Perceptions+Vary+Depending+on+Stage+of+Readiness+for+Colorectal+Cancer+Screening&rft.au=Ferrer%2C+Rebecca+A%3BHall%2C+Kara+L%3BPortnoy%2C+David+B%3BLing%2C+Bruce+S%3BHan%2C+Paul+K.J.%3BKlein%2C+William+M.P.&rft.aulast=Ferrer&rft.aufirst=Rebecca&rft.date=2011-09-01&rft.volume=30&rft.issue=5&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Health+Psychology&rft.issn=02786133&rft_id=info:doi/10.1037%2Fa0023583 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Perceptions; Health; Cancer; Screening; Colorectal cancer; Readiness DO - http://dx.doi.org/10.1037/a0023583 ER - TY - JOUR T1 - Pilot Test of an Emotional Education Intervention Component for Sexual Risk Reduction AN - 1010707443; 201208279 AB - Objective: Emotions are key predictors of sexual risk behavior but have been largely ignored in theory-based intervention development. The present study aims to evaluate whether the addition of an emotional education intervention component to a traditional social-cognitive safer sex intervention increases intervention efficacy, compared with both a social-cognitive only intervention and a no intervention control condition. Methods: Young adults were randomized in small groups to receive the social-cognitive-emotional (SCE) intervention, the social-cognitive (SC) intervention, or standard of care. Results: Analyses of data from 176 participants indicated that intervention arms reported similar increased condom use compared with the no intervention control arm at 3 months' postintervention (beta = .06, p = .41, d = 0.08). However, at 6 months' postintervention, individuals in the SCE intervention arm reported increased condom use compared with both the SC intervention (beta = .27, p = .04, d = 0.38) and control arms (beta = .37, p < .01; d = 0.56), demonstrating preliminary evidence that the addition of an emotional education component may facilitate sustained behavior change. Conclusions: An emotional education intervention module has the potential to facilitate sustained behavior change at delayed follow-up. Additional research is necessary to replicate findings in a larger sample and to determine the mediators of emotional education intervention efficacy. [Copyright The American Psychological Association.] JF - Health Psychology AU - Ferrer, Rebecca A AU - Fisher, Jeffrey D AU - Buck, Ross AU - Amico, K Rivet AD - Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland ferrerra@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 656 EP - 660 PB - American Psychological Association, Washington DC VL - 30 IS - 5 SN - 0278-6133, 0278-6133 KW - emotion intervention sexual risk reduction HIV prevention emotional education KW - Condoms KW - Emotions KW - Safe sexual practices KW - Efficacy KW - Behavioural changes KW - Arms KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010707443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Psychology&rft.atitle=Pilot+Test+of+an+Emotional+Education+Intervention+Component+for+Sexual+Risk+Reduction&rft.au=Ferrer%2C+Rebecca+A%3BFisher%2C+Jeffrey+D%3BBuck%2C+Ross%3BAmico%2C+K+Rivet&rft.aulast=Ferrer&rft.aufirst=Rebecca&rft.date=2011-09-01&rft.volume=30&rft.issue=5&rft.spage=656&rft.isbn=&rft.btitle=&rft.title=Health+Psychology&rft.issn=02786133&rft_id=info:doi/10.1037%2Fa0023438 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Safe sexual practices; Condoms; Behavioural changes; Efficacy; Arms; Emotions DO - http://dx.doi.org/10.1037/a0023438 ER - TY - JOUR T1 - A Query Expansion Framework in Image Retrieval Domain Based on Local and Global Analysis AN - 1010627447; 201204853 AB - We present an image retrieval framework based on automatic query expansion in a concept feature space by generalizing the vector space model of information retrieval. In this framework, images are represented by vectors of weighted concepts similar to the keyword-based representation used in text retrieval. To generate the concept vocabularies, a statistical model is built by utilizing Support Vector Machine (SVM)-based classification techniques. The images are represented as "bag of concepts" that comprise perceptually and/or semantically distinguishable color and texture patches from local image regions in a multi-dimensional feature space. To explore the correlation between the concepts and overcome the assumption of feature independence in this model, we propose query expansion techniques in the image domain from a new perspective based on both local and global analysis. For the local analysis, the correlations between the concepts based on the co-occurrence pattern, and the metrical constraints based on the neighborhood proximity between the concepts in encoded images, are analyzed by considering local feedback information. We also analyze the concept similarities in the collection as a whole in the form of a similarity thesaurus and propose an efficient query expansion based on the global analysis. The experimental results on a photographic collection of natural scenes and a biomedical database of different imaging modalities demonstrate the effectiveness of the proposed framework in terms of precision and recall. Adapted from the source document. JF - Information Processing and Management AU - Rahman, M M AU - Antani, S K AU - Thoma, G R AD - U.S. National Library of Medicine, National Institutes of Health Bethesda, MD, USA rahmanmm@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 676 EP - 691 PB - Elsevier Ltd., Kidlington Oxford UK VL - 47 IS - 5 SN - 0306-4573, 0306-4573 KW - Image retrieval, vector space model, support vector machine, relevance feedback, query expansion KW - Information retrieval KW - Image retrieval KW - Relevance feedback KW - Query expansion KW - article KW - 13.13: AUTOMATIC TEXT ANALYSIS, AUTOMATIC INDEXING, MACHINE TRANSLATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010627447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Information+Processing+and+Management&rft.atitle=A+Query+Expansion+Framework+in+Image+Retrieval+Domain+Based+on+Local+and+Global+Analysis&rft.au=Rahman%2C+M+M%3BAntani%2C+S+K%3BThoma%2C+G+R&rft.aulast=Rahman&rft.aufirst=M&rft.date=2011-09-01&rft.volume=47&rft.issue=5&rft.spage=676&rft.isbn=&rft.btitle=&rft.title=Information+Processing+and+Management&rft.issn=03064573&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Query expansion; Image retrieval; Relevance feedback; Information retrieval ER - TY - JOUR T1 - Toxicokinetics of bis(2-chloroethoxy)methane following intravenous administration and dermal application in male and female F344/N rats and B6C3F1 mice AN - 883022542; 15380548 AB - In the National Toxicology Program's toxicity studies, rats were more sensitive than mice to Bis(2-chloroethoxy)methane (CEM) - induced cardiac toxicity following dermal application to male and female F344/N rats and B6C3F1 mice. Thiodiglycolic acid (TDGA) is a major metabolite of CEM in rats. It has been implicated that chemicals metabolized to TDGA cause cardiac toxicity in humans. Therefore, the toxicokinetics of CEM and TDGA were investigated in male and female F344/N rats and B6C3F1 mice following a single intravenous administration or dermal application of CEM to aid in the interpretation of the toxicity data. Absorption of CEM following dermal application was rapid in both species and genders. Bioavailability following dermal application was low but was higher in rats than in mice with females of both species showing higher bioavailability than males. CEM was rapidly distributed to the heart, thymus, and liver following both routes of administration. Plasma CEM Cmax and AUC( infinity ) increased proportionally with dose, although at the dermal dose of 400mg/kg in rats and 600mg/kg in mice non-linear kinetics were apparent. Following dermal application, dose-normalized plasma CEM C JF - Toxicology Letters AU - Waidyanatha, S AU - Johnson, J D AU - Hong, S P AU - Godfrey-Robinson, V D AU - Graves, S W AU - Cristy, T AU - Dunnick, J K AU - Smith, C S Y1 - 2011/08/28/ PY - 2011 DA - 2011 Aug 28 SP - 215 EP - 226 PB - Elsevier B.V., Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland VL - 205 IS - 2 SN - 0378-4274, 0378-4274 KW - Environment Abstracts; Toxicology Abstracts KW - CEM KW - TDGA KW - GC KW - MS KW - Bis(2-chloroethoxy)methane KW - Thiodiglycolic acid KW - Bioavailability KW - Toxicokinetics KW - Metabolism KW - Chemicals KW - Heart KW - Intravenous administration KW - Skin KW - Data processing KW - Thymus KW - thiodiglycolic acid KW - Mice KW - Metabolites KW - Toxicity KW - Rats KW - Kinetics KW - Absorption KW - Liver KW - intravenous administration KW - X 24300:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883022542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Toxicokinetics+of+bis%282-chloroethoxy%29methane+following+intravenous+administration+and+dermal+application+in+male+and+female+F344%2FN+rats+and+B6C3F1+mice&rft.au=Waidyanatha%2C+S%3BJohnson%2C+J+D%3BHong%2C+S+P%3BGodfrey-Robinson%2C+V+D%3BGraves%2C+S+W%3BCristy%2C+T%3BDunnick%2C+J+K%3BSmith%2C+C+S&rft.aulast=Waidyanatha&rft.aufirst=S&rft.date=2011-08-28&rft.volume=205&rft.issue=2&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2011.06.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Heart; Bioavailability; Intravenous administration; Data processing; Skin; Kinetics; Thymus; thiodiglycolic acid; Liver; Metabolites; Toxicity; Chemicals; Rats; Absorption; Mice; intravenous administration DO - http://dx.doi.org/10.1016/j.toxlet.2011.06.012 ER - TY - JOUR T1 - Catechol-o-methyl transferase (COMT) val super(158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls) AN - 885051292; 15458519 AB - Non-psychotic individuals at increased risk for schizophrenia show alterations in fronto-striatal dopamine signaling and cortical gray matter maturation reminiscent of those seen in schizophrenia. It remains unclear however if variations in dopamine signaling influence rates of structural cortical maturation in typically developing individuals, and whether such influences are disrupted in patients with schizophrenia and their non-psychotic siblings. We sought to address these issues by relating a functional Val -- Met polymorphism within the gene encoding catechol-o-methyltransferase (COMT) - a key enzymatic regulator of cortical dopamine levels - to longitudinal structural neuroimaging measures of cortical gray matter thickness. We included a total of 792 magnetic resonance imaging brain scans, acquired between ages 9 and 22 years from patients with childhood-onset schizophrenia (COS), their non-psychotic full siblings, and matched healthy controls. Whereas greater Val allele dose (which confers enhanced dopamine catabolism and is proposed to aggravate cortical deficits in schizophrenia) accelerated adolescent cortical thinning in both schizophrenia probands and their siblings, it attenuated cortical thinning in healthy controls. This similarity between COS patients and their siblings was accompanied by differences between the two groups in the timing and spatial distribution of disrupted COMT influences on cortical maturation. Consequently, whereas greater Val "dose" conferred persistent dorsolateral prefrontal cortical deficits amongst affected probands by adulthood, cortical thickness differences associated with varying Val dose in non-psychotic siblings resolved over the age-range studied. These findings suggest that cortical abnormalities in pedigrees affected by schizophrenia may be contributed to by a disruption of dopaminergic infleunces on cortical maturation. JF - NeuroImage AU - Raznahan, Armin AU - Greenstein, Deanna AU - Lee, Yohan AU - Long, Robert AU - Clasen, Liv AU - Gochman, Pete AU - Addington, Anjene AU - Giedd, Jay N AU - Rapoport, Judith L AU - Gogtay, Nitin Y1 - 2011/08/15/ PY - 2011 DA - 2011 Aug 15 SP - 1517 EP - 1523 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 57 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Adolescence KW - Schizophrenia KW - W 30910:Imaging KW - N3:11001 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885051292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Catechol-o-methyl+transferase+%28COMT%29+val+super%28158met+polymorphism+and+adolescent+cortical+development+in+patients+with+childhood-onset+schizophrenia%2C+their+non-psychotic+siblings%2C+and+healthy+controls%29&rft.au=Raznahan%2C+Armin%3BGreenstein%2C+Deanna%3BLee%2C+Yohan%3BLong%2C+Robert%3BClasen%2C+Liv%3BGochman%2C+Pete%3BAddington%2C+Anjene%3BGiedd%2C+Jay+N%3BRapoport%2C+Judith+L%3BGogtay%2C+Nitin&rft.aulast=Raznahan&rft.aufirst=Armin&rft.date=2011-08-15&rft.volume=57&rft.issue=4&rft.spage=1517&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2011.05.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Schizophrenia DO - http://dx.doi.org/10.1016/j.neuroimage.2011.05.032 ER - TY - JOUR T1 - Smoking before the first pregnancy and the risk of breast cancer: a meta-analysis. AN - 881086439; 21719745 AB - The authors conducted a meta-analysis of the association between smoking before a first pregnancy, when undifferentiated breast tissue may be vulnerable to tobacco carcinogens, and the risk of breast cancer. A search of the published literature through August 2010 identified 23 papers reporting on associations between smoking before a first pregnancy and breast cancer. Odds ratios or hazard ratios and 95% confidence intervals, adjusted for known or suspected breast cancer risk factors, were abstracted from each study. Data were pooled using both fixed- and random-effects models. The fixed-effect summary risk ratio for breast cancer among the women who smoked before their first pregnancy versus women who had never smoked was 1.10 (95% confidence interval: 1.07, 1.14); the random-effects estimate was similar. The separate fixed-effect risk ratios for smoking only before the first pregnancy (5 studies) or only after the first pregnancy (16 studies) were both 1.07, providing no evidence that breast tissue is more susceptible to malignant transformation from smoking before the first pregnancy. While these small summary risk ratios may represent causal effects, residual confounding could readily produce estimates of this size in the absence of any causal effect. JF - American journal of epidemiology AU - DeRoo, Lisa A AU - Cummings, Peter AU - Mueller, Beth A AD - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle,Washington, USA. DeRooL@niehs.nih.gov Y1 - 2011/08/15/ PY - 2011 DA - 2011 Aug 15 SP - 390 EP - 402 VL - 174 IS - 4 KW - Index Medicus KW - Parity KW - Risk Factors KW - Humans KW - Incidence KW - Female KW - Pregnancy KW - Breast Neoplasms -- etiology KW - Smoking -- adverse effects KW - Breast Neoplasms -- epidemiology KW - Smoking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881086439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Smoking+before+the+first+pregnancy+and+the+risk+of+breast+cancer%3A+a+meta-analysis.&rft.au=DeRoo%2C+Lisa+A%3BCummings%2C+Peter%3BMueller%2C+Beth+A&rft.aulast=DeRoo&rft.aufirst=Lisa&rft.date=2011-08-15&rft.volume=174&rft.issue=4&rft.spage=390&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwr090 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-27 N1 - Date created - 2011-08-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 2007 Nov 5;97(9):1287-90 [17912245] Epidemiology. 2007 Sep;18(5):629-38 [17700252] Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):1-2 [18187387] Breast Cancer Res Treat. 2008 May;109(1):101-11 [17594514] Breast Cancer Res Treat. 2008 May;109(1):67-75 [17972172] BMC Cancer. 2008;8:157 [18518960] Ann Epidemiol. 2011 Jan;21(1):53-5 [21130370] Am J Epidemiol. 1996 May 1;143(9):918-28 [8610705] Stat Med. 2000 Dec 30;19(24):3325-36 [11122498] Microsc Res Tech. 2001 Jan 15;52(2):204-23 [11169868] Cancer Causes Control. 2001 Feb;12(2):179-85 [11246847] Epidemiology. 2002 Mar;13(2):138-45 [11880753] Breast Cancer Res Treat. 2002 Sep;75(2):181-4 [12243511] Am J Epidemiol. 2002 Oct 1;156(7):616-26 [12244030] Lancet. 2002 Oct 5;360(9339):1044-9 [12383984] Br J Cancer. 2002 Nov 18;87(11):1234-45 [12439712] Cancer Causes Control. 2003 Feb;14(1):43-51 [12708724] Cancer Causes Control. 2003 Jun;14(5):497-503 [12946045] BMJ. 2003 Sep 6;327(7414):557-60 [12958120] J Natl Cancer Inst. 2004 Jan 7;96(1):29-37 [14709736] Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):398-404 [15006915] Int J Cancer. 2004 Jun 20;110(3):413-6 [15095307] Br J Cancer. 2004 Aug 2;91(3):512-8 [15226777] Environ Res. 2004 Oct;96(2):176-85 [15325878] Control Clin Trials. 1986 Sep;7(3):177-88 [3802833] Br J Cancer. 1988 Dec;58(6):832-7 [3224085] Epidemiol Rev. 1992;14:154-76 [1289110] Cancer Epidemiol Biomarkers Prev. 1994 Jun;3(4):353-64 [8061586] Biometrics. 1994 Dec;50(4):1088-101 [7786990] BMJ. 1997 Sep 13;315(7109):629-34 [9310563] Carcinogenesis. 1997 Nov;18(11):2127-32 [9395212] Cancer Res. 1998 Feb 15;58(4):667-71 [9485019] Am J Epidemiol. 1999 Jan 1;149(1):5-12 [9883788] Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):61-6 [15668477] Cancer Causes Control. 2005 Oct;16(8):975-85 [16132806] Mayo Clin Proc. 2005 Nov;80(11):1423-8 [16295021] Int J Cancer. 2006 Oct 15;119(8):1961-9 [16721725] Breast Cancer Res Treat. 2006 Dec;100(3):293-9 [16773435] Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):620-2 [17372262] Am J Epidemiol. 2007 Jul 1;166(1):55-61 [17426039] BMJ. 2007 Nov 3;335(7626):914-6 [17974687] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwr090 ER - TY - JOUR T1 - We don't know what we don't study: the case for research on medication effects in pregnancy. AN - 878593961; 21766436 AB - This Commentary addresses issues related to exposures to teratogens and makes the case for increased research into the safety of medication usage during pregnancy for mothers and fetuses. Not only are medications commonly used during pregnancy, but evidence points to an increasing prevalence and number of drug exposures experienced by the embryo or fetus, particularly during the critical first trimester of pregnancy. Although the first trimester represents a particularly vulnerable period of organogenesis, exposures during other gestational time periods may also be associated with deleterious outcomes. In addition to the changing (and in many cases unknown) risks to a developing fetus, other challenges to studying medication exposures and their effects during pregnancy include the dramatic changes in physiology that occur in pregnant women and the ethical dilemmas posed by including this vulnerable population in randomized controlled trials of safety and efficacy. However, without adequate knowledge of the pharmacokinetics, pharmacodynamics, efficacy, and safety of medication use in pregnancy, women may be under-dosed to minimize exposure or not treated at all, resulting in inadequate treatment and potential harm to the mother and her baby. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) is undertaking studies on medications and teratogenic exposures during pregnancy, including alcohol, maternal diabetes, oral hypoglycemic agents, and antiviral medications, through several of its research networks. Although this is a start, there is a critical need for further research on medications used during pregnancy, especially their effects on both the mother and her developing child. Published 2011 Wiley-Liss, Inc. JF - American journal of medical genetics. Part C, Seminars in medical genetics AU - Parisi, Melissa A AU - Spong, Catherine Y AU - Zajicek, Anne AU - Guttmacher, Alan E AD - Intellectual and Developmental Disabilities Branch, Center for Developmental Biology and Perinatal Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Boulevard, Bethesda, MD 20892-7510, USA. parisima@mail.nih.gov Y1 - 2011/08/15/ PY - 2011 DA - 2011 Aug 15 SP - 247 EP - 250 VL - 157C IS - 3 KW - Teratogens KW - 0 KW - Index Medicus KW - Prenatal Exposure Delayed Effects -- prevention & control KW - Prenatal Exposure Delayed Effects -- chemically induced KW - Humans KW - Pregnancy Complications -- drug therapy KW - Abnormalities, Drug-Induced -- etiology KW - Abnormalities, Drug-Induced -- prevention & control KW - Female KW - Risk Assessment KW - Pregnancy Outcome KW - Pregnancy KW - Drug-Related Side Effects and Adverse Reactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878593961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+medical+genetics.+Part+C%2C+Seminars+in+medical+genetics&rft.atitle=We+don%27t+know+what+we+don%27t+study%3A+the+case+for+research+on+medication+effects+in+pregnancy.&rft.au=Parisi%2C+Melissa+A%3BSpong%2C+Catherine+Y%3BZajicek%2C+Anne%3BGuttmacher%2C+Alan+E&rft.aulast=Parisi&rft.aufirst=Melissa&rft.date=2011-08-15&rft.volume=157C&rft.issue=3&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=American+journal+of+medical+genetics.+Part+C%2C+Seminars+in+medical+genetics&rft.issn=1552-4876&rft_id=info:doi/10.1002%2Fajmg.c.30309 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-23 N1 - Date created - 2011-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Public Health. 2009 Oct;99 Suppl 2:S248-54 [19461110] Aust N Z J Obstet Gynaecol. 2009 Apr;49(2):168-72 [19432605] Science. 2010 Jan 1;327(5961):36-7 [20044560] Am J Obstet Gynecol. 2011 Jun;204(6 Suppl 1):S89-93 [21492824] Am J Obstet Gynecol. 2011 Jun;204(6 Suppl 1):S84-8 [21492826] Am J Med Genet C Semin Med Genet. 2011 Aug 15;157C(3):175-82 [21766440] Am J Obstet Gynecol. 2011 Jul;205(1):51.e1-8 [21514558] Teratology. 2000 Apr;61(4):314-7 [10716751] J Psychiatry Neurosci. 2001 Jan;26(1):44-8 [11212593] N Engl J Med. 2004 Jul 15;351(3):241-9 [15254282] Am J Obstet Gynecol. 2004 Aug;191(2):398-407 [15343213] Teratology. 1990 Jun;41(6):657-61 [2353314] JAMA. 2006 Feb 1;295(5):499-507 [16449615] N Engl J Med. 2006 Feb 9;354(6):579-87 [16467545] Clin Pharmacol Ther. 2007 Apr;81(4):547-56 [17329990] Birth Defects Res A Clin Mol Teratol. 2007 Apr;79(4):301-8 [17216624] N Engl J Med. 2007 Jun 28;356(26):2675-83 [17596601] N Engl J Med. 2007 Jun 28;356(26):2684-92 [17596602] Clin Pharmacol Ther. 2008 Jan;83(1):181-3 [18073777] PLoS Med. 2008 Jan 22;5(1):e22 [18215109] Birth Defects Res A Clin Mol Teratol. 2009 Jan;85(1):63-8 [19107954] Obstet Gynecol. 2009 Oct;114(4):885-91 [19888049] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ajmg.c.30309 ER - TY - JOUR T1 - Nitric oxide donor, V-PROLI/NO, provides protection against arsenical induced toxicity in rat liver cells: requirement for Cyp1a1. AN - 874898175; 21621526 AB - Arsenic is a cancer chemotherapeutic but hepatotoxicity can be a limiting side effect. O(2)-vinyl 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (V-PROLI/NO) is a nitric oxide (NO) donor prodrug and metabolized by liver cytochromes P450 (CYP450) to release NO. The effects of V-PROLI/NO pretreatment on the toxicity of arsenic (as NaAsO(2)) were studied in a rat liver cell line (TRL 1215). The cells acted upon the prodrug to release NO, as assessed by nitrite levels, in a time-dependent fashion to maximal levels of 8-fold above basal levels. Pretreatment with V-PROLI/NO markedly reduced arsenic cytolethality which was directly related to the level of NO produced by V-PROLI/NO treatment. Cyp1a1 expression was directly related to the level of NO production and to reduced arsenic cytotoxicity. V-PROLI/NO pretreatment markedly reduced arsenic-induced apoptosis and suppressed phosphorylation of JNK1/2. V-PROLI/NO pretreatment facilitated additional increases in arsenic-induced metallothionein, a metal-binding protein important in arsenic tolerance. Thus, V-PROLI/NO protects against arsenic toxicity in rat liver cells, reducing cytolethality, apoptosis and dysregulation of MAPKs, through generation of NO formed after metabolism by liver cell enzymes, possibly including Cyp1a1. CYP450 required for NO production from V-PROLI/NO treatment in the rat and human appears to differ as we have previously studied the ability of V-PROLI/NO to prevent arsenic toxicity in human liver cells where it reduced toxicity apparently through a CYP2E1-mediated metabolic mechanism. None-the-less, it appears that both rat and human liver cells act upon V-PROLI/NO via a CYP450-related mechanism to produce NO and subsequently reduce arsenic toxicity. Published by Elsevier Ireland Ltd. JF - Chemico-biological interactions AU - Qu, Wei AU - Cheng, Lida AU - Dill, Anna L AU - Saavedra, Joseph E AU - Hong, Sam Y AU - Keefer, Larry K AU - Waalkes, Michael P AD - National Toxicology Program, National Institute of Environmental Health Sciences and Laboratory of Comparative Carcinogenesis, National Cancer Institute, 111 Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2011/08/15/ PY - 2011 DA - 2011 Aug 15 SP - 88 EP - 96 VL - 193 IS - 1 KW - Nitric Oxide Donors KW - 0 KW - O2-vinyl 1-(2-(carboxylato)pyrrolidin-1-yl)diazen-1-ium-1,2-diolate KW - Prodrugs KW - Pyrrolidines KW - Triazenes KW - Nitric Oxide KW - 31C4KY9ESH KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - MAP Kinase Kinase 4 KW - EC 2.7.12.2 KW - MAP Kinase Kinase 7 KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Rats KW - MAP Kinase Kinase 7 -- metabolism KW - Animals KW - Apoptosis KW - Mitogen-Activated Protein Kinases -- metabolism KW - Nitric Oxide -- metabolism KW - MAP Kinase Kinase 4 -- metabolism KW - Cell Line KW - Triazenes -- pharmacology KW - Cytochrome P-450 CYP1A1 -- genetics KW - Hepatocytes -- drug effects KW - Arsenic -- toxicity KW - Prodrugs -- chemistry KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Nitric Oxide Donors -- pharmacology KW - Prodrugs -- pharmacology KW - Pyrrolidines -- chemistry KW - Pyrrolidines -- pharmacology KW - Triazenes -- chemistry KW - Hepatocytes -- metabolism KW - Nitric Oxide Donors -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874898175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Nitric+oxide+donor%2C+V-PROLI%2FNO%2C+provides+protection+against+arsenical+induced+toxicity+in+rat+liver+cells%3A+requirement+for+Cyp1a1.&rft.au=Qu%2C+Wei%3BCheng%2C+Lida%3BDill%2C+Anna+L%3BSaavedra%2C+Joseph+E%3BHong%2C+Sam+Y%3BKeefer%2C+Larry+K%3BWaalkes%2C+Michael+P&rft.aulast=Qu&rft.aufirst=Wei&rft.date=2011-08-15&rft.volume=193&rft.issue=1&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=1872-7786&rft_id=info:doi/10.1016%2Fj.cbi.2011.05.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-09 N1 - Date created - 2011-07-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Med Chem. 1996 Oct 25;39(22):4361-5 [8893830] J Biol Chem. 1996 Jun 28;271(26):15703-7 [8663189] J Med Chem. 1997 Jun 20;40(13):1947-54 [9207935] Anesthesiology. 1998 Jan;88(1):190-5 [9447872] Am J Physiol. 1998 Sep;275(3 Pt 1):L551-8 [9728050] Annu Rev Pharmacol Toxicol. 1999;39:267-94 [10331085] Cancer Res. 1999 Jul 1;59(13):3053-8 [10397243] Toxicol Sci. 1999 Jun;49(2):156-64 [10416260] J Pharm Sci. 2006 Jan;95(1):108-15 [16315224] Leukemia. 2006 May;20(5):881-3 [16525498] Nitric Oxide. 2006 Jun;14(4):309-15 [16545970] J Am Chem Soc. 2006 Sep 27;128(38):12473-83 [16984198] J Natl Cancer Inst. 2007 May 2;99(9):667-8 [17470732] Environ Health Perspect. 2007 Jul;115(7):1101-6 [17637929] Org Lett. 2007 Aug 16;9(17):3409-12 [17658755] Acta Pharmacol Sin. 2007 Sep;28(9):1429-33 [17723176] Cancer Lett. 2007 Oct 28;256(2):238-45 [17658681] Biochem Soc Trans. 2007 Nov;35(Pt 5):1364-8 [17956352] Biochemistry. 2008 Feb 26;47(8):2231-43 [18237198] Blood. 2008 Mar 1;111(5):2505-15 [18299451] Toxicol Appl Pharmacol. 2008 Jun 1;229(2):252-61 [18328521] Toxicol Sci. 2008 Sep;105(1):24-32 [18566022] Cancer Sci. 2009 Mar;100(3):382-8 [19154403] Expert Opin Drug Metab Toxicol. 2009 May;5(5):501-21 [19416086] BMC Cancer. 2009;9:187 [19531241] J Natl Cancer Inst. 2009 Dec 16;101(24):1670-81 [19933942] Toxicol Appl Pharmacol. 2010 May 1;244(3):291-9 [20083128] Toxicol Sci. 2000 Jun;55(2):460-7 [10828279] Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14382-7 [11121042] Biol Trace Elem Res. 2000 Winter;78(1-3):241-54 [11314982] Toxicol Lett. 2001 Feb 28;119(2):103-8 [11311571] Toxicol Sci. 2001 Oct;63(2):189-95 [11568362] Carcinogenesis. 2002 Jan;23(1):151-9 [11756236] Annu Rev Pharmacol Toxicol. 2003;43:585-607 [12415121] Chem Res Toxicol. 2003 Jul;16(7):873-80 [12870890] J Biol Chem. 2004 Jul 30;279(31):32700-8 [15161912] Toxicol Appl Pharmacol. 1982 Oct;66(1):134-42 [7157381] Fundam Appl Toxicol. 1993 Feb;20(2):184-9 [8449390] Science. 1995 Nov 24;270(5240):1326-31 [7481820] Blood. 1997 May 1;89(9):3354-60 [9129042] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.cbi.2011.05.005 ER - TY - JOUR T1 - Risk factors for non-Hodgkin lymphoma subtypes defined by histology and t(14; 18) in a population-based case-control study AN - 1017961459; 16689862 AB - The t(14; 18) chromosomal translocation is the most common cytogenetic abnormality in non-Hodgkin lymphoma (NHL), occurring in 70-90% of follicular lymphomas (FL) and 30-50% of diffuse large B-cell lymphomas (DLBCL). Previous t(14; 18)-NHL studies have not evaluated risk factors for NHL defined by both t(14; 18) status and histology. In this population-based case-control study, t(14; 18) status was determined in DLBCL cases using fluorescence in situ hybridization on paraffin-embedded tumor sections. Polytomous logistic regression was used to evaluate the association between a wide variety of exposures and t(14; 18)-positive (N = 109) and -negative DLBCL (N = 125) and FL (N = 318), adjusting for sex, age, race, and study center. Taller height, more lifetime surgeries, and PCB180 exposure were associated with t(14; 18)-positivity. Taller individuals (third tertile vs. first tertile) had elevated risks of t(14; 18)-positive DLBCL (odds ratio [OR] = 1.8, 95% confidence interval [CI] 1.1-3.0) and FL (OR = 1.4, 95%CI 1.0-1.9) but not t(14; 18)-negative DLBCL. Similar patterns were seen for individuals with more lifetime surgeries (13+ vs. 0-12 surgeries; t(14; 18)-positive DLBCL OR = 1.4, 95%CI 0.7-2.7; FL OR = 1.6, 95%CI 1.1-2.5) and individuals exposed to PCB180 greater than 20.8 ng/g (t(14; 18)-positive DLBCL OR = 1.3, 95%CI 0.6-2.9; FL OR = 1.7, 95%CI 1.0-2.8). In contrast, termite treatment and high alpha-chlordane levels were associated with t(14; 18)-negative DLBCL only, suggesting that these exposures do not act through t(14; 18). Our findings suggest that putative associations between NHL and height, surgeries, and PCB180 may be t(14; 18)-mediated and provide support for case-subtyping based on molecular and histologic subtypes. Future efforts should focus on pooling data to confirm and extend previous research on risk factors for t(14; 18)-NHL subtypes. JF - International Journal of Cancer AU - Chang, Cindy M AU - Wang, Sophia S AU - Dave, Bhavana J AU - Jain, Smrati AU - Vasef, Mohammad A AU - Weisenburger, Dennis D AU - Cozen, Wendy AU - Davis, Scott AU - Severson, Richard K AU - Lynch, Charles F AU - Rothman, Nathaniel AU - Cerhan, James R AU - Hartge, Patricia AU - Morton, Lindsay M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, changcm@mail.nih.gov Y1 - 2011/08/15/ PY - 2011 DA - 2011 Aug 15 SP - 938 EP - 947 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 129 IS - 4 SN - 1097-0215, 1097-0215 KW - Immunology Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Cancer KW - Chromosome translocations KW - Data processing KW - Fluorescence KW - Fluorescence in situ hybridization KW - Histology KW - Races KW - Risk factors KW - Sex KW - Surgery KW - Translocation KW - Tumors KW - double prime B-cell lymphoma KW - lymphoma KW - non-Hodgkin's lymphoma KW - surgery KW - translocation KW - tumors KW - Isoptera KW - H 11000:Diseases/Injuries/Trauma KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017961459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Risk+factors+for+non-Hodgkin+lymphoma+subtypes+defined+by+histology+and+t%2814%3B+18%29+in+a+population-based+case-control+study&rft.au=Chang%2C+Cindy+M%3BWang%2C+Sophia+S%3BDave%2C+Bhavana+J%3BJain%2C+Smrati%3BVasef%2C+Mohammad+A%3BWeisenburger%2C+Dennis+D%3BCozen%2C+Wendy%3BDavis%2C+Scott%3BSeverson%2C+Richard+K%3BLynch%2C+Charles+F%3BRothman%2C+Nathaniel%3BCerhan%2C+James+R%3BHartge%2C+Patricia%3BMorton%2C+Lindsay+M&rft.aulast=Chang&rft.aufirst=Cindy&rft.date=2011-08-15&rft.volume=129&rft.issue=4&rft.spage=938&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=10970215&rft_id=info:doi/10.1002%2Fijc.25717 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ijc.25717/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Age; Data processing; double prime B-cell lymphoma; Chromosome translocations; Risk factors; Surgery; Tumors; Races; Sex; Fluorescence in situ hybridization; non-Hodgkin's lymphoma; Fluorescence; Histology; tumors; translocation; Translocation; lymphoma; Cancer; surgery; Isoptera DO - http://dx.doi.org/10.1002/ijc.25717 ER - TY - JOUR T1 - Structural basis of M3 muscarinic receptor dimer/oligomer formation. AN - 883311900; 21685385 AB - Class A G protein-coupled receptors (GPCRs) are known to form dimers and/or oligomeric arrays in vitro and in vivo. These complexes are thought to play important roles in modulating class A GPCR function. Many studies suggest that residues located on the "outer" (lipid-facing) surface of the transmembrane (TM) receptor core are critically involved in the formation of class A receptor dimers (oligomers). However, no clear consensus has emerged regarding the identity of the TM helices or TM subsegments involved in this process. To shed light on this issue, we have used the M(3) muscarinic acetylcholine receptor (M3R), a prototypic class A GPCR, as a model system. Using a comprehensive and unbiased approach, we subjected all outward-facing residues (70 amino acids total) of the TM helical bundle (TM1-7) of the M3R to systematic alanine substitution mutagenesis. We then characterized the resulting mutant receptors in radioligand binding and functional studies and determined their ability to form dimers (oligomers) in bioluminescence resonance energy transfer saturation assays. We found that M3R/M3R interactions are not dependent on the presence of one specific structural motif but involve the outer surfaces of multiple TM subsegments (TM1-5 and -7) located within the central and endofacial portions of the TM receptor core. Moreover, we demonstrated that the outward-facing surfaces of most TM helices play critical roles in proper receptor folding and/or function. Guided by the bioluminescence resonance energy transfer data, molecular modeling studies suggested the existence of multiple dimeric/oligomeric M3R arrangements, which may exist in a dynamic equilibrium. Given the high structural homology found among all class A GPCRs, our results should be of considerable general relevance. JF - The Journal of biological chemistry AU - McMillin, Sara M AU - Heusel, Moritz AU - Liu, Tong AU - Costanzi, Stefano AU - Wess, Jürgen AD - Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health,Bethesda, Maryland 20892, USA. Y1 - 2011/08/12/ PY - 2011 DA - 2011 Aug 12 SP - 28584 EP - 28598 VL - 286 IS - 32 KW - Receptor, Muscarinic M3 KW - 0 KW - Index Medicus KW - Structural Homology, Protein KW - Animals KW - Peptide Mapping KW - COS Cells KW - Amino Acid Motifs KW - Humans KW - Cercopithecus aethiops KW - Amino Acid Substitution KW - Mutagenesis KW - Protein Multimerization -- physiology KW - Protein Folding KW - Receptor, Muscarinic M3 -- metabolism KW - Receptor, Muscarinic M3 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883311900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Structural+basis+of+M3+muscarinic+receptor+dimer%2Foligomer+formation.&rft.au=McMillin%2C+Sara+M%3BHeusel%2C+Moritz%3BLiu%2C+Tong%3BCostanzi%2C+Stefano%3BWess%2C+J%C3%BCrgen&rft.aulast=McMillin&rft.aufirst=Sara&rft.date=2011-08-12&rft.volume=286&rft.issue=32&rft.spage=28584&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M111.259788 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-11 N1 - Date created - 2011-08-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 1993 Jan;12(1):331-8 [7679072] Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):3103-7 [8385357] J Biol Chem. 1994 Jan 7;269(1):402-5 [8276826] J Biol Chem. 1995 Jul 28;270(30):18000-6 [7629108] J Biol Chem. 1996 Jul 5;271(27):16384-92 [8663163] Crit Rev Neurobiol. 1996;10(1):69-99 [8853955] Pharmacol Rev. 1998 Jun;50(2):279-90 [9647869] Pharmacol Ther. 1998 Dec;80(3):231-64 [9888696] J Biol Chem. 1999 Jul 2;274(27):19487-97 [10383466] Brain Res Mol Brain Res. 2005 Jan 5;133(1):6-11 [15661360] J Biol Chem. 2005 Feb 18;280(7):5664-75 [15572356] FEBS J. 2005 Jun;272(12):2926-38 [15955053] Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17495-500 [16301531] Nat Methods. 2006 Mar;3(3):165-74 [16489332] J Biol Chem. 2006 Mar 3;281(9):5416-25 [16368694] Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3054-9 [16492774] Cell Metab. 2006 Jun;3(6):449-61 [16753580] Nat Methods. 2007 Feb;4(2):169-74 [17206152] Pharmacol Rev. 2007 Mar;59(1):5-13 [17329545] Mol Pharmacol. 2007 Apr;71(4):1015-29 [17220353] Biochim Biophys Acta. 2007 Apr;1768(4):825-35 [17069751] Proc Natl Acad Sci U S A. 2007 May 1;104(18):7682-7 [17452637] J Struct Biol. 2007 Jun;158(3):455-62 [17374491] Nat Rev Drug Discov. 2007 Sep;6(9):721-33 [17762886] J Biol Chem. 2007 Oct 19;282(42):30363-72 [17726027] Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18303-8 [17989235] J Biol Chem. 2008 Feb 15;283(7):4387-94 [18033822] Nat Rev Drug Discov. 2008 Apr;7(4):339-57 [18382464] Trends Pharmacol Sci. 2008 May;29(5):234-40 [18384890] Cancer Res. 2008 May 15;68(10):3573-8 [18483237] Nature. 2008 Jul 24;454(7203):486-91 [18594507] EMBO J. 2008 Sep 3;27(17):2293-304 [18668123] Nat Methods. 2009 Mar;6(3):225-30 [19234451] Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6398-403 [19332789] FEBS J. 2009 May;276(10):2786-800 [19459935] Mol Pharmacol. 2009 Jun;75(6):1296-9 [19273553] Mol Pharmacol. 2009 Aug;76(2):264-74 [19429716] Nat Chem Biol. 2009 Sep;5(9):688-95 [19648932] EMBO J. 2009 Nov 4;28(21):3315-28 [19763081] J Physiol. 2009 Nov 15;587(Pt 22):5337-44 [19723778] Nature. 2010 Jan 7;463(7277):108-12 [20054398] Trends Pharmacol Sci. 2010 Jan;31(1):15-21 [19963287] Curr Opin Pharmacol. 2010 Feb;10(1):23-9 [19850521] Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2693-8 [20133736] Cell Metab. 2010 Mar 3;11(3):231-8 [20197056] J Biol Chem. 2010 Apr 16;285(16):12435-44 [20172855] J Biol Chem. 2010 May 28;285(22):16723-38 [20304928] Nat Chem Biol. 2010 Jul;6(7):541-8 [20512139] Nat Chem Biol. 2010 Aug;6(8):587-94 [20622858] Trends Biotechnol. 2010 Aug;28(8):407-15 [20542584] Trends Biochem Sci. 2010 Nov;35(11):595-600 [20538466] Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12199-204 [17620610] Science. 2000 Mar 17;287(5460):1960-4 [10720314] Neuron. 2000 Jul;27(1):97-106 [10939334] Annu Rev Pharmacol Toxicol. 2002;42:409-35 [11807178] J Mol Biol. 2001 Nov 30;314(3):455-63 [11846559] Nat Rev Mol Cell Biol. 2002 Sep;3(9):639-50 [12209124] J Biol Chem. 2002 Nov 22;277(47):44925-31 [12244098] Nature. 2003 Jan 9;421(6919):127-8 [12520290] J Biol Chem. 2003 Feb 14;278(7):4385-8 [12496294] Mol Endocrinol. 2003 Apr;17(4):677-91 [12554793] J Biol Chem. 2003 Jun 13;278(24):21655-62 [12663652] J Biol Chem. 2003 Sep 12;278(37):35345-53 [12835319] Nat Immunol. 2004 Feb;5(2):216-23 [14716309] FEBS Lett. 2004 Apr 30;564(3):281-8 [15111110] J Biol Chem. 2004 Jul 2;279(27):28756-65 [15123695] Mol Pharmacol. 2004 Aug;66(2):312-21 [15266022] Mol Pharmacol. 2004 Nov;66(5):1123-37 [15304550] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M111.259788 ER - TY - JOUR T1 - Evaluating a hybrid web-based basic genetics course for health professionals AN - 964269942; 201207597 AB - Health professionals, particularly nurses, continue to struggle with the expanding role of genetics information in the care of their patients. This paper describes an evaluation study of the effectiveness of a hybrid basic genetics course for healthcare professionals combining web-based learning with traditional face-to-face instructional techniques. A multidisciplinary group from the National Institutes of Health (NIH) created "Basic Genetics Education for Healthcare Providers" (BGEHCP). This program combined 7 web-based self-education modules with monthly traditional face-to-face lectures by genetics experts. The course was pilot tested by 186 healthcare providers from various disciplines with 69% (n=129) of the class registrants enrolling in a pre-post evaluation trial. Outcome measures included critical thinking knowledge items and a Web-based Learning Environment Inventory (WEBLEI). Results indicated a significant (p<0.001) change in knowledge scores. WEBLEI scores indicated program effectiveness particularly in the area of convenience, access and the course structure and design. Although significant increases in overall knowledge scores were achieved, scores in content areas surrounding genetic risk identification and ethical issues regarding genetic testing reflected continued gaps in knowledge. Web-based genetics education may help overcome genetics knowledge deficits by providing access for health professionals with diverse schedules in a variety of national and international settings. [Copyright Elsevier Ltd.] JF - Nurse Education Today AU - Wallen, Gwenyth R AU - Cusack, Georgie AU - Parada, Suzan AU - Miller-Davis, Claiborne AU - Cartledge, Tannia AU - Yates, Jan AD - National Institutes of Health, Clinical Center, Nursing Research and Translational Science, 10 Center Drive, Room 2B14, MSC-1151, Bethesda, MD 20892-1151, United States Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 638 EP - 642 PB - Elsevier Ltd, Amsterdam The Netherlands VL - 31 IS - 6 SN - 0260-6917, 0260-6917 KW - Genetics education WEBLEI Web-based nursing education KW - Professional knowledge KW - Health professionals KW - Health care KW - Computer based KW - Genetic screening KW - Internet KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964269942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nurse+Education+Today&rft.atitle=Evaluating+a+hybrid+web-based+basic+genetics+course+for+health+professionals&rft.au=Wallen%2C+Gwenyth+R%3BCusack%2C+Georgie%3BParada%2C+Suzan%3BMiller-Davis%2C+Claiborne%3BCartledge%2C+Tannia%3BYates%2C+Jan&rft.aulast=Wallen&rft.aufirst=Gwenyth&rft.date=2011-08-01&rft.volume=31&rft.issue=6&rft.spage=638&rft.isbn=&rft.btitle=&rft.title=Nurse+Education+Today&rft.issn=02606917&rft_id=info:doi/10.1016%2Fj.nedt.2010.11.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Computer based; Internet; Health professionals; Health care; Professional knowledge; Genetic screening DO - http://dx.doi.org/10.1016/j.nedt.2010.11.001 ER - TY - JOUR T1 - A partially linear regression model for data from an outcome-dependent sampling design AN - 940980625; 4280472 AB - The outcome-dependent sampling scheme has been gaining attention in both the statistical literature and applied fields. Epidemiological and environmental researchers have been using it to select the observations for more powerful and cost-effective studies. Motivated by a study of the effect of in utero exposure to poly-chlorinated biphenyls on children's intelligence quotient at age 7 years, in which the effect of an important confounding variable is non-linear, we consider a semiparametric regression model for data from an outcome-dependent sampling scheme where the relationship between the response and covariates is only partially parameterized. We propose a penalized spline maximum likelihood estimation for inference on both the parametric and the non-parametric components and develop their asymptotic properties. Through simulation studies and an analysis of the intelligence study, we compare the proposed estimator with several competing estimators. Practical considerations of implementing those estimators are discussed. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Longnecker, Matthew P AU - Zhou, Haibo AU - You, Jinhong AU - Qin, Guoyou AD - University of North Carolina, Chapel Hill ; National Institute of Environmental Health Sciences Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 559 EP - 574 VL - 60 IS - 4 SN - 0035-9254, 0035-9254 KW - Economics KW - Regression analysis KW - Simulation KW - Maximum likelihood method KW - Linear models KW - Sampling KW - Statistical methods KW - Data analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/940980625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=A+partially+linear+regression+model+for+data+from+an+outcome-dependent+sampling+design&rft.au=Longnecker%2C+Matthew+P%3BZhou%2C+Haibo%3BYou%2C+Jinhong%3BQin%2C+Guoyou&rft.aulast=Longnecker&rft.aufirst=Matthew&rft.date=2011-08-01&rft.volume=60&rft.issue=4&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=00359254&rft_id=info:doi/10.1111%2Fj.1467-9876.2010.00756.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 7419 8163; 10739 12228 10919; 3279 971 3286; 11255 12228 10919; 12228 10919; 7837 8160 8163 12230; 11670 DO - http://dx.doi.org/10.1111/j.1467-9876.2010.00756.x ER - TY - JOUR T1 - Intrathecal gene therapy for treatment of leptomeningeal carcinomatosis AN - 910647961; 15420327 AB - Leptomeningeal carcinomatosis occurs occasionally in patients with solid malignancies and carries a poor prognosis despite treatment with systemic chemotherapy and/or radiotherapy. We describe the case of a 43 year old man who presented with leptomeningeal carcinomatosis secondary to malignant melanoma. The patient received intraventricular delivery of NIH3T3 producer cells expressing the thymidine kinase (HSV-Tk1) gene via a retroviral vector followed by intravenous ganciclovir. He experienced abrupt and severe meningeal irritation and hyperpyrexia immediately after injection of the producer cells into the ventricular CSF. Vector producer cells (VPC) survived and were detected by NeoR marker gene expression in the CSF for a week, until a single dose of ganciclovir (GCV) was followed by a decline in the copy number of the NeoR marker gene to undetectable levels over 24 h. This decline upon introduction of ganciclovir suggests effective distribution of ganciclovir to producer cells bearing the HSV-Tk gene. The patient survived 9 months after treatment. Side-effects from the treatment included acute hyperpyrexia which was short-lived and medically manageable. JF - Journal of Neuro-Oncology AU - Heiss, John D AU - Taha, Sara AU - Oldfield, Edward H AU - Ram, Zvi AD - Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, 10-3D20, MSC-1414, Bethesda, MD, 20892-1414, USA, heissj@ninds.nih.gov Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 365 EP - 369 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 104 IS - 1 SN - 0167-594X, 0167-594X KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Cerebrospinal fluid KW - Chemotherapy KW - Expression vectors KW - Ganciclovir KW - Gene therapy KW - Intravenous administration KW - Irritation KW - Malignancy KW - Melanoma KW - Meninges KW - Oncology KW - Producer cells KW - Prognosis KW - Radiotherapy KW - Side effects KW - Thymidine kinase KW - copy number KW - G 07720:Immunogenetics KW - W 30905:Medical Applications KW - N3 11023:Neurogenetics KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/910647961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuro-Oncology&rft.atitle=Intrathecal+gene+therapy+for+treatment+of+leptomeningeal+carcinomatosis&rft.au=Heiss%2C+John+D%3BTaha%2C+Sara%3BOldfield%2C+Edward+H%3BRam%2C+Zvi&rft.aulast=Heiss&rft.aufirst=John&rft.date=2011-08-01&rft.volume=104&rft.issue=1&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuro-Oncology&rft.issn=0167594X&rft_id=info:doi/10.1007%2Fs11060-010-0458-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-12-03 N1 - SubjectsTermNotLitGenreText - Intravenous administration; Gene therapy; Chemotherapy; Producer cells; Prognosis; Radiotherapy; Oncology; Ganciclovir; Thymidine kinase; Irritation; Melanoma; copy number; Expression vectors; Meninges; Cerebrospinal fluid; Malignancy; Side effects DO - http://dx.doi.org/10.1007/s11060-010-0458-4 ER - TY - JOUR T1 - A stratified genetic risk assessment for testicular cancer AN - 907183814; 15726079 AB - Three genome-wide association studies of testicular cancer have uncovered predisposition alleles in or near KITLG, BAK1, SPRY4, TERT, ATF7IP and DMRT1. We investigated whether testicular cancer-risk alleles can be utilized in the clinical setting. We employed the receiver operating characteristic curves for genetic risk models to measure the discriminatory power of a risk variant-based risk model, and found that the newly discovered variants provided a discriminatory power of 69.2%. This suggested that about 69.2% of the time, a randomly selected patient with testicular cancer had a higher estimated risk than the risk for a randomly selected control subject. Using a multiplicative model, we estimated that white men in the top 1% of genetic risk as defined by eight risk variants had a relative risk that was 10.5-fold greater than that for the general white male population. This risk differential does not appear to be clinically useful, given the relative rarity and highly curable nature of testicular germ cell tumour (TGCT). In the authors' view, a stratified genetic risk assessment strategy might be useful, theoretically, for men who also have independent clinical risk factors for testicular cancer. Several established TGCT risk factors, such as cryptorchidism (RR=4.8) and male infertility (SIR=2.8) might prove useful in that context, but we currently do not know whether these testicular cancer-risk loci are associated with, or independent of, such clinical risk factors. More research is required before we can utilize testicular cancer-risk loci for clinically meaningful risk prediction. JF - International Journal of Andrology AU - Kratz, C P AU - Greene, M H AU - Bratslavsky, G AU - Shi, J AD - Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - e98 EP - e102 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 34 IS - 4pt2 SN - 0105-6263, 0105-6263 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Cancer KW - Prediction KW - Risk assessment KW - Risk factors KW - infertility KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907183814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Andrology&rft.atitle=A+stratified+genetic+risk+assessment+for+testicular+cancer&rft.au=Kratz%2C+C+P%3BGreene%2C+M+H%3BBratslavsky%2C+G%3BShi%2C+J&rft.aulast=Kratz&rft.aufirst=C&rft.date=2011-08-01&rft.volume=34&rft.issue=4pt2&rft.spage=e98&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Andrology&rft.issn=01056263&rft_id=info:doi/10.1111%2Fj.1365-2605.2011.01156.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Document feature - figure 2 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Prediction; Risk assessment; infertility; Risk factors; Cancer DO - http://dx.doi.org/10.1111/j.1365-2605.2011.01156.x ER - TY - JOUR T1 - Personal exposure to PM2.5 among high-school students in Milan and background measurements: The EuroLifeNet study AN - 904487639; 15167575 AB - As part of the EuroLifeNet program we measured personal exposure to PM2.5 in 90 pupils attending three schools in Milan, over a three-week period spanning November and December 2006, using a portable light-scattering nephelometer. The primary aim was to investigate the relationship between personal exposure to PM2.5 and background measurements obtained from a fixed monitoring station. Pearson's correlation coefficient between sampled daily mean exposures and reference values from background station varied from 0.64 to 0.75, with an overall value of 0.63, indicating good agreement. We also estimated that about 40% of the variability in the mean daily personal exposure at the three schools was due to variability in background exposure, the remaining 60% due to between-subject differences in exposures or to other sources of error. JF - Atmospheric Environment AU - Borgini, A AU - Tittarelli, A AU - Ricci, C AU - Bertoldi, M AU - De Saeger, E AU - Crosignani, P AD - Cancer Registry and Environmental Epidemiology Unit, National Cancer Institute, Via Venezian 1, 20133 Milano, Italy, alessandro.borgini@istitutotumori.mi.it Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 4147 EP - 4151 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 45 IS - 25 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Environment Abstracts; Meteorological & Geoastrophysical Abstracts KW - Particle size KW - Particulate matter in atmosphere KW - Atmospheric pollution KW - schools KW - nephelometers KW - Correlations KW - Nephelometers KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904487639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Personal+exposure+to+PM2.5+among+high-school+students+in+Milan+and+background+measurements%3A+The+EuroLifeNet+study&rft.au=Borgini%2C+A%3BTittarelli%2C+A%3BRicci%2C+C%3BBertoldi%2C+M%3BDe+Saeger%2C+E%3BCrosignani%2C+P&rft.aulast=Borgini&rft.aufirst=A&rft.date=2011-08-01&rft.volume=45&rft.issue=25&rft.spage=4147&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2011.05.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Number of references - 1 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Particulate matter in atmosphere; Atmospheric pollution; Nephelometers; Correlations; Particle size; nephelometers; schools DO - http://dx.doi.org/10.1016/j.atmosenv.2011.05.026 ER - TY - JOUR T1 - Reproducible High Yields of Recombinant Adeno-Associated Virus Produced Using Invertebrate Cells in 0.02- to 200-Liter Cultures AN - 902367717; 15742354 AB - The large amounts of recombinant adeno-associated virus (rAAV) vector needed for clinical trials and eventual commercialization require robust, economical, reproducible, and scalable production processes compatible with current good manufacturing practice. rAAV produced using baculovirus and insect cells satisfies these conditions; however, recovering rAAV particles from 200-liter bioreactors is more complicated than bench-scale vector preparations. Using a variety of processing media, we developed a reliable and routine downstream procedure for rAAV production that is scalable from 0.02- to 200-liter cultures. To facilitate the upstream process, we adapted the titerless infected-cell preservation and scale-up process for rAAV production. Single-use aliquots of cryopreserved baculovirus-infected insect cells (BIIC) are thawed and added to the suspension culture to achieve the desired ratio of BIIC to rAAV-producer cells. By using conditions established with small-scale cultures, rAAV was produced in larger volume cultures. Strikingly consistent rAAV yields were attained in cultures ranging from 10 liters to 200 liters. Based on the final yield, each cell produced 18,000 plus or minus 6,800 particles of purified rAAV in 10-, 20-, 100-, and 200-liter cultures. Thus, with an average cell density of 4.32x10 super(6) cells/ml, greater than or equal to 10 super(16) purified rAAV particles are produced from 100 to 200 liters. The downstream process resulted in about 20% recovery estimated from comparing the quantities of capsid protein antigen in the crude bioreactor material and in the final, purified product. The ease and reproducibility of rAAV production in 200-liter bioreactors suggest that the limit has not been reached, and 500-liter productions are planned. JF - Human Gene Therapy AU - Cecchini, S AU - Virag, T AU - Kotin, R M AD - Laboratory of Molecular Virology and Gene Therapy, Building 10, Room 7D05, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA, kotinr@nhlbi.nih.gov Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 1021 EP - 1030 VL - 22 IS - 8 SN - 1043-0342, 1043-0342 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene therapy KW - Cell density KW - Cell culture KW - Suspension culture KW - Clinical trials KW - Cryopreservation KW - Adeno-associated virus KW - Bioreactors KW - Insect cells KW - Invertebrata KW - Preservation KW - Baculovirus KW - Media (culture) KW - Capsid protein KW - W 30905:Medical Applications KW - G 07880:Human Genetics KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902367717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Reproducible+High+Yields+of+Recombinant+Adeno-Associated+Virus+Produced+Using+Invertebrate+Cells+in+0.02-+to+200-Liter+Cultures&rft.au=Cecchini%2C+S%3BVirag%2C+T%3BKotin%2C+R+M&rft.aulast=Cecchini&rft.aufirst=S&rft.date=2011-08-01&rft.volume=22&rft.issue=8&rft.spage=1021&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2010.250 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Gene therapy; Insect cells; Bioreactors; Cell density; Suspension culture; Cell culture; Preservation; Cryopreservation; Clinical trials; Media (culture); Capsid protein; Invertebrata; Baculovirus; Adeno-associated virus DO - http://dx.doi.org/10.1089/hum.2010.250 ER - TY - JOUR T1 - Association between inhibited binding of folic acid to folate receptor alpha in maternal serum and folate-related birth defects in Norway AN - 899170768; 15601895 AB - BACKGROUND Folic acid intake during pregnancy can reduce the risk of neural tube defects (NTDs) and perhaps also oral facial clefts. Maternal autoantibodies to folate receptors can impair folic acid binding. We explored the relationship of these birth defects to inhibition of folic acid binding to folate receptor alpha (FR alpha ), as well as possible effects of parental demographics or prenatal exposures. METHODS We conducted a nested case-control study within the Norwegian Mother and Child Cohort Study. The study included mothers of children with an NTD (n= 11), cleft lip with or without cleft palate (CL/P, n= 72), or cleft palate only (CPO, n= 27), and randomly selected mothers of controls (n= 221). The inhibition of folic acid binding to FR alpha was measured in maternal plasma collected around 17 weeks of gestation. On the basis of prior literature, the maternal age, gravidity, education, smoking, periconception folic acid supplement use and milk consumption were considered as potential confounding factors. RESULTS There was an increased risk of NTDs with increased binding inhibition [adjusted odds ratio (aOR) = 1.4, 95% confidence interval (CI) 1.0-1.8]. There was no increased risk of oral facial clefts from inhibited folic acid binding to FR alpha (CL/P aOR = 0.7, 95% CI 0.6-1.0; CPO aOR = 1.1, 95% CI 0.8-1.4). No association was seen between smoking, folate supplementation or other cofactors and inhibition of folic acid binding to FR alpha . CONCLUSIONS Inhibition of folic acid binding to FR alpha in maternal plasma collected during pregnancy was associated with increased risk of NTDs but not oral facial clefts. JF - Human Reproduction AU - Boyles, AL AU - Ballard, J L AU - Gorman, E B AU - McConnaughey AU - Cabrera, R M AU - Wilcox, A J AU - Lie, R T AU - Finnell, R H AD - 2 Texas A&M Institute for Genomic Medicine, College Station, TX 77843, USA, boylesa@niehs.nih.gov Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 2232 EP - 2238 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 26 IS - 8 SN - 0268-1161, 0268-1161 KW - Risk Abstracts KW - demography KW - Milk KW - Pregnancy KW - folic acid KW - Smoking KW - risk reduction KW - Education KW - Congenital defects KW - Reproduction KW - Norway KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899170768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Reproduction&rft.atitle=Association+between+inhibited+binding+of+folic+acid+to+folate+receptor+alpha+in+maternal+serum+and+folate-related+birth+defects+in+Norway&rft.au=Boyles%2C+AL%3BBallard%2C+J+L%3BGorman%2C+E+B%3BMcConnaughey%3BCabrera%2C+R+M%3BWilcox%2C+A+J%3BLie%2C+R+T%3BFinnell%2C+R+H&rft.aulast=Boyles&rft.aufirst=AL&rft.date=2011-08-01&rft.volume=26&rft.issue=8&rft.spage=2232&rft.isbn=&rft.btitle=&rft.title=Human+Reproduction&rft.issn=02681161&rft_id=info:doi/10.1093%2Fhumrep%2Fder144 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - demography; folic acid; risk reduction; Smoking; Education; Milk; Congenital defects; Reproduction; Pregnancy; Norway DO - http://dx.doi.org/10.1093/humrep/der144 ER - TY - JOUR T1 - Associations of Medically Documented Psychiatric Diagnoses and Risky Health Behaviors in Highly Active Antiretroviral Therapy-Experienced Perinatally HIV-Infected Youth AN - 893272011; 15630677 AB - The Longitudinal Epidemiologic Study to Gain Insight into HIV/AIDS in Children and Youth (LEGACY) study is a prospective, multisite, longitudinal cohort of U.S. HIV-infected youth. This analysis was limited to perinatally HIV-infected youth (n=197), 13 years and older, with selected variables completely abstracted from HIV diagnosis through 2006. We evaluated relationships between ever having one or more nonsubstance related medically documented psychiatric diagnoses and three risky health behaviors (substance abuse, preadult sexual activity, and treatment adherence problems) recorded between 2001 and 2006. Logistic regression was used for all binary outcomes and participant age was included as a covariate when possible. All 197 participants included in the analysis were prescribed antiretroviral therapy during the study period; 110 (56%) were female, 100 (51%) were black non-Hispanic, and 86 (44%) were Hispanic; mean age at the last visit was 16.8 years, ranging from 13 to 24 years. One hundred forty-six (74%) participants had a history of at least one risky health behavior. There were 108 (55%) participants with at least one medically documented psychiatric diagnosis, 17 (9%) with at least one record of substance abuse, 12 (6%) with documented preadult sexual activity, and 142 (72%) participants with reported adherence problems. In the final model, a history of at least one psychiatric diagnosis was associated with having at least one of the three risky behaviors (odds ratio [OR]=2.33, p=0.015). There is a need for a continued close partnership between HIV specialty care providers and mental health services treating perinatally HIV-infected youth with an added focus on improving treatment adherence. JF - AIDS Patient Care and STDs AU - Kapetanovic, S AU - Wiegand, R E AU - Dominguez, K AU - Blumberg, D AU - Bohannon, B AU - Wheeling, J AU - Rutstein, R AD - National Institutes of Health, National Institute of Mental Health, Office of the Clinical Director, Building 10-CRC, Room 6-5340, 10 Center Drive, Bethesda, MD 20892-1276, USA, suad.kapetanovic@nih.gov Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 493 EP - 501 VL - 25 IS - 8 SN - 1087-2914, 1087-2914 KW - Health & Safety Science Abstracts; Risk Abstracts; Virology & AIDS Abstracts KW - Historical account KW - Age KW - Acquired immune deficiency syndrome KW - antiretroviral therapy KW - Drug abuse KW - Children KW - Models KW - substance abuse KW - USA KW - Mental disorders KW - Behavior KW - Antiviral agents KW - Human immunodeficiency virus KW - antiretroviral agents KW - sexually transmitted diseases KW - Ethnic groups KW - Substance abuse KW - Sexually transmitted diseases KW - V 22360:AIDS and HIV KW - H 4000:Food and Drugs KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893272011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Patient+Care+and+STDs&rft.atitle=Associations+of+Medically+Documented+Psychiatric+Diagnoses+and+Risky+Health+Behaviors+in+Highly+Active+Antiretroviral+Therapy-Experienced+Perinatally+HIV-Infected+Youth&rft.au=Kapetanovic%2C+S%3BWiegand%2C+R+E%3BDominguez%2C+K%3BBlumberg%2C+D%3BBohannon%2C+B%3BWheeling%2C+J%3BRutstein%2C+R&rft.aulast=Kapetanovic&rft.aufirst=S&rft.date=2011-08-01&rft.volume=25&rft.issue=8&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=AIDS+Patient+Care+and+STDs&rft.issn=10872914&rft_id=info:doi/10.1089%2Fapc.2011.0107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Mental disorders; Age; Antiviral agents; antiretroviral therapy; Children; Drug abuse; Models; substance abuse; Historical account; Behavior; Human immunodeficiency virus; antiretroviral agents; Sexually transmitted diseases; Substance abuse; Ethnic groups; sexually transmitted diseases; USA DO - http://dx.doi.org/10.1089/apc.2011.0107 ER - TY - JOUR T1 - Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits. AN - 893264300; 21626413 AB - In the last decade, a growing scientific and medical interest has emerged toward cardiovascular effects of dietary nitrite and nitrate; however, many questions concerning their mode of action(s) remain unanswered. In this review, we focus on multiple mechanisms that might account for potential cardiovascular beneficial effects of dietary nitrite and nitrate. Beneficial changes to cardiovascular health from dietary nitrite and nitrate might result from several mechanism(s) including their reduction into nitric oxide, improvement in endothelial function, vascular relaxation, and/or inhibition of the platelet aggregation. From recently obtained evidence, it appears that the longstanding concerns about the toxicity of oral nitrite or nitrate are overstated. Dietary nitrite and nitrate may have cardiovascular protective effects in both healthy individuals and also those with cardiovascular disease conditions. A role for nitrite and nitrate in nitric oxide biosynthesis and/or in improving nitric oxide bioavailability may eventually provide a rationale for using dietary nitrite and nitrate supplementation in the treatment and prevention of cardiovascular diseases. JF - European journal of nutrition AU - Machha, Ajay AU - Schechter, Alan N AD - Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 293 EP - 303 VL - 50 IS - 5 KW - Nitrates KW - 0 KW - Nitrites KW - Platelet Aggregation Inhibitors KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Animals KW - Endothelium -- metabolism KW - Humans KW - Dietary Supplements KW - Biological Availability KW - Nitric Oxide -- pharmacokinetics KW - Cardiovascular Diseases -- drug therapy KW - Nitric Oxide -- biosynthesis KW - Nitrates -- pharmacokinetics KW - Diet KW - Nitrites -- pharmacokinetics KW - Cardiovascular Diseases -- prevention & control KW - Platelet Aggregation Inhibitors -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893264300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+nutrition&rft.atitle=Dietary+nitrite+and+nitrate%3A+a+review+of+potential+mechanisms+of+cardiovascular+benefits.&rft.au=Machha%2C+Ajay%3BSchechter%2C+Alan+N&rft.aulast=Machha&rft.aufirst=Ajay&rft.date=2011-08-01&rft.volume=50&rft.issue=5&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=European+journal+of+nutrition&rft.issn=1436-6215&rft_id=info:doi/10.1007%2Fs00394-011-0192-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-19 N1 - Date created - 2011-08-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Free Radic Biol Med. 2008 Aug 15;45(4):468-74 [18501719] Nitric Oxide. 2008 Dec;19(4):333-7 [18793740] J Biol Chem. 2008 Dec 5;283(49):33927-34 [18835812] Basic Res Cardiol. 2009 Mar;104(2):113-9 [19242636] Front Biosci (Landmark Ed). 2009;14:4793-808 [19273390] Arch Intern Med. 2009 Apr 13;169(7):659-69 [19364995] Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1281-8 [19252084] Free Radic Biol Med. 2009 Apr 15;46(8):1068-75 [19439233] Kidney Int. 2009 Jun;75(11):1140-4 [19212422] Hypertension. 2009 Aug;54(2):322-8 [19581509] Med Res Rev. 2009 Sep;29(5):683-741 [19219851] Br J Pharmacol. 2009 Aug;157(8):1523-30 [19594749] Nat Rev Cardiol. 2009 Sep;6(9):599-608 [19652655] Atherosclerosis. 2009 Sep;206(1):61-8 [19268941] Arch Pharm Res. 2009 Aug;32(8):1119-26 [19727604] Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2068-74 [19820197] J Biol Chem. 2009 Dec 4;284(49):33850-8 [19801639] Nitric Oxide. 2010 Feb 15;22(2):136-40 [19887114] Int Heart J. 2010 Jan;51(1):1-6 [20145343] Cancer Res. 2010 Mar 15;70(6):2406-14 [20215514] Hypertension. 2010 Aug;56(2):274-81 [20585108] Cancer. 2010 Sep 15;116(18):4345-53 [20681011] Am J Cardiovasc Drugs. 2010;10(5):315-20 [20860414] Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17716-20 [20876122] Heart. 2010 Nov;96(21):1703-9 [20736204] Methods Mol Biol. 2011;704:39-56 [21161628] Curr Opin Lipidol. 2011 Feb;22(1):11-5 [21102328] Br J Nutr. 1999 May;81(5):349-58 [10615207] Public Health Nutr. 2000 Mar;3(1):103-7 [10786730] Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11482-7 [11027349] Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):355-60 [11134509] Nitric Oxide. 2002 Aug;7(1):24-9 [12175816] Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):336-41 [12502793] Natl Toxicol Program Tech Rep Ser. 2001 May;495:7-273 [12563346] Free Radic Biol Med. 2003 Mar 1;34(5):576-84 [12614846] J Clin Invest. 2003 Apr;111(8):1201-9 [12697739] J Agric Food Chem. 2003 Sep 24;51(20):6014-20 [13129310] Curr Atheroscler Rep. 2003 Nov;5(6):492-9 [14525683] Free Radic Biol Med. 2003 Oct 1;35(7):790-6 [14583343] Nat Med. 2003 Dec;9(12):1498-505 [14595407] Free Radic Biol Med. 2004 Feb 15;36(4):413-22 [14975444] Clin Sci (Lond). 2004 May;106(5):443-5 [14741042] Blood Cells Mol Dis. 2004 May-Jun;32(3):423-9 [15121102] Free Radic Biol Med. 2004 Aug 1;37(3):395-400 [15223073] Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13683-8 [15347817] Nat Med. 2004 Oct;10(10):1122-7 [15361865] Food Cosmet Toxicol. 1976 Dec;14(6):545-8 [1017769] Food Cosmet Toxicol. 1976 Dec;14(6):549-52 [1017770] Proc Natl Acad Sci U S A. 1977 Aug;74(8):3203-7 [20623] Can J Physiol Pharmacol. 1981 Feb;59(2):150-6 [6112057] Food Chem Toxicol. 1984 Oct;22(10):789-95 [6541617] J Pharmacol Exp Ther. 1990 Jan;252(1):35-41 [2153807] Clin Biochem. 1990 Feb;23(1):67-71 [2184959] Int J Epidemiol. 1990 Sep;19(3):510-5 [2262241] Pharmacol Toxicol. 1991 Jan;68(1):60-3 [1848931] Pharmacol Rev. 1991 Jun;43(2):109-42 [1852778] Circ Res. 1993 Feb;72(2):403-12 [8418991] Nature. 1994 Apr 7;368(6471):502 [8139683] Gut. 1994 Nov;35(11):1543-6 [7828969] Biochem Biophys Res Commun. 1995 Apr 17;209(2):590-6 [7794389] Br J Clin Pharmacol. 1995 Apr;39(4):460-2 [7640157] Nat Med. 1995 Jun;1(6):546-51 [7585121] Nat Med. 1995 Aug;1(8):804-9 [7585184] Am J Surg. 1996 Aug;172(2):158-61; 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15465823 AB - In this study, we aimed to estimate serum 25-hydroxy vitamin D (25-OH-D) in Asian Indians and test for association between 25-OH-D levels, insulin resistance (IR) and metabolic syndrome (MS). Serum 25-OH-D was measured in a cross-sectional sample of 441 Indians, aged 39.7+/-12.8 years (237 men and 204 women) with 27.9% prevalence of MS. Vitamin D insufficiency (12.5 to 0.05). Although highly prevalent, vitamin D insufficient status was not associated with MS or IR in Asian Indians of either sex. JF - International Journal of Obesity AU - Majumdar, V AU - Nagaraja, D AU - Christopher, R AD - Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore, India Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 1131 EP - 1134 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 35 IS - 8 SN - 0307-0565, 0307-0565 KW - Health & Safety Science Abstracts KW - metabolic disorders KW - vitamins KW - insulin KW - obesity KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888113489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Obesity&rft.atitle=Vitamin+D+status+and+metabolic+syndrome+in+Asian+Indians&rft.au=Majumdar%2C+V%3BNagaraja%2C+D%3BChristopher%2C+R&rft.aulast=Majumdar&rft.aufirst=V&rft.date=2011-08-01&rft.volume=35&rft.issue=8&rft.spage=1131&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Obesity&rft.issn=03070565&rft_id=info:doi/10.1038%2Fijo.2010.232 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2014-10-30 N1 - SubjectsTermNotLitGenreText - metabolic disorders; vitamins; insulin; obesity DO - http://dx.doi.org/10.1038/ijo.2010.232 ER - TY - JOUR T1 - HIV type 1 Env precursor cleavage state affects recognition by both neutralizing and nonneutralizing gp41 antibodies. AN - 886912551; 21158699 AB - HIV-1 is relatively resistant to antibody-mediated neutralization; however, rare antibodies to the exterior envelope glycoprotein, gp120, and the transmembrane glycoprotein, gp41, can neutralize a broad array of isolates. Two antibodies, 2F5 and 4E10, are directed against the gp41 membrane proximal external region (MPER); however, the kinetic neutralization signature of these antibodies remains unresolved. Previously, we reported that the fully cleaved, cell surface envelope glycoproteins (Env) derived from the primary isolate, JR-FL, are well recognized exclusively by gp120-directed neutralizing ligands and not by nonneutralizing gp120 antibodies. However, the gp120 nonneutralizing antibodies can recognize HIV spikes that are rendered fully cleavage defective by site-directed mutagenesis. Here, we extended such analysis to gp41 neutralizing and nonneutralizing antibodies and, relative to the rules of gp120-specific antibody recognition, we observed marked contrasts. Similar to gp120 recognition, the nonneutralizing gp41 cluster 1 or cluster 2 antibodies bound much more efficiently to cleavage-defective spikes when compared to their recognition of cleaved spikes. In contrast to gp120 neutralizing antibody recognition, the broadly neutralizing gp41 antibodies 2F5 and 4E10, like the nonneutralizing gp41 antibodies, did not efficiently recognize the predominantly cleaved, primary isolate JR-FL spikes. However, if the spikes were rendered cleavage defective, recognition by both the neutralizing and nonneutralizing ligand markedly increased. CD4 interaction with the cleaved spikes mark