TY - JOUR T1 - HGPS-Derived iPSCs For The Ages AN - 954611621; 14185605 AB - In this issue of Cell Stem Cell, Zhang et al. (2011) generate patient-derived iPSCs for one of the major premature aging diseases, Hutchinson-Gilford Progeria Syndrome (HGPS). These cells are a much-needed new tool to study HGPS, and their use may lead to novel insights into mechanisms of aging. JF - Cell Stem Cell AU - Misteli, Tom Y1 - 2011/01/07/ PY - 2011 DA - 2011 Jan 07 SP - 4 EP - 6 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA VL - 8 IS - 1 SN - 1934-5909, 1934-5909 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Progeria KW - Stem cells KW - Inhibitory postsynaptic potentials KW - Aging KW - W 30965:Miscellaneous, Reviews KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954611621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Stem+Cell&rft.atitle=HGPS-Derived+iPSCs+For+The+Ages&rft.au=Misteli%2C+Tom&rft.aulast=Misteli&rft.aufirst=Tom&rft.date=2011-01-07&rft.volume=8&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Cell+Stem+Cell&rft.issn=19345909&rft_id=info:doi/10.1016%2Fj.stem.2010.12.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Progeria; Stem cells; Aging; Inhibitory postsynaptic potentials DO - http://dx.doi.org/10.1016/j.stem.2010.12.014 ER - TY - JOUR T1 - Presynaptic protein synthesis required for NT-3-induced long-term synaptic modulation AN - 923193328; 14324454 AB - Neurotrophins elicit both acute and long-term modulation of synaptic transmission and plasticity. Previously, we demonstrated that the long-term synaptic modulation requires the endocytosis of neurotrophin-receptor complex, the activation of PI3K and Akt, and mTOR mediated protein synthesis. However, it is unclear whether the long-term synaptic modulation by neurotrophins depends on protein synthesis in pre- or post-synaptic cells. Here we have developed an inducible protein translation blocker, in which the kinase domain of protein kinase R (PKR) is fused with bacterial gyrase B domain (GyrB-PKR), which could be dimerized upon treatment with a cell permeable drug, coumermycin. By genetically targeting GyrB-PKR to specific cell types, we show that NT-3 induced long-term synaptic modulation requires presynaptic, but not postsynaptic protein synthesis. Our results provide mechanistic insights into the cell-specific requirement for protein synthesis in the long-term synaptic modulation by neurotrophins. The GyrB-PKR system may be useful tool to study protein synthesis in a cell-specific manner. JF - Molecular Brain AU - Je, H Shawn AU - Ji, Yuanyuan AU - Wang, Ying AU - Yang, Feng AU - Wu, Wei AU - Lu, Bai AD - Genes, Cognition and Psychosis Program (GCAP), National Institute of Mental Health, NIH, Bethesda, MD 20892, U.S.A Y1 - 2011/01/07/ PY - 2011 DA - 2011 Jan 07 SP - 1 PB - BioMed Central Ltd., Floor 6 London WC1X 8HL UK VL - 4 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Translation KW - eIF-2 kinase KW - Protein biosynthesis KW - DNA topoisomerase KW - Plasticity (synaptic) KW - Endocytosis KW - protein kinase R KW - 1-Phosphatidylinositol 3-kinase KW - Neuromodulation KW - AKT protein KW - Synaptic transmission KW - Neurotrophin 3 KW - TOR protein KW - Drugs KW - N3 11007:Neurobiology KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/923193328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Brain&rft.atitle=Presynaptic+protein+synthesis+required+for+NT-3-induced+long-term+synaptic+modulation&rft.au=Je%2C+H+Shawn%3BJi%2C+Yuanyuan%3BWang%2C+Ying%3BYang%2C+Feng%3BWu%2C+Wei%3BLu%2C+Bai&rft.aulast=Je&rft.aufirst=H&rft.date=2011-01-07&rft.volume=4&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Molecular+Brain&rft.issn=1756-6606&rft_id=info:doi/10.1186%2F1756-6606-4-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Translation; Protein biosynthesis; eIF-2 kinase; DNA topoisomerase; Plasticity (synaptic); protein kinase R; Endocytosis; Neuromodulation; 1-Phosphatidylinositol 3-kinase; AKT protein; Neurotrophin 3; Synaptic transmission; TOR protein; Drugs DO - http://dx.doi.org/10.1186/1756-6606-4-1 ER - TY - JOUR T1 - Shedding of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus from adult and pediatric bathers in marine waters AN - 907148973; 14323964 AB - Staphylococcus aureus including methicillin resistant S. aureus, MRSA, are human colonizing bacteria that commonly cause opportunistic infections primarily involving the skin in otherwise healthy individuals. These infections have been linked to close contact and sharing of common facilities such as locker rooms, schools and prisons Waterborne exposure and transmission routes have not been traditionally associated with S. aureus infections. Coastal marine waters and beaches used for recreation are potential locations for the combination of high numbers of people with close contact and therefore could contribute to the exposure to and infection by these organisms. The primary aim of this study was to evaluate the amount and characteristics of the shedding of methicillin sensitive S. aureus, MSSA and MRSA by human bathers in marine waters. Nasal cultures were collected from bathers, and water samples were collected from two sets of pools designed to isolate and quantify MSSA and MRSA shed by adults and toddlers during exposure to marine water. A combination of selective growth media and biochemical and polymerase chain reaction analysis was used to identify and perform limited characterization of the S. aureus isolated from the water and the participants. Twelve of 15 MRSA isolates collected from the water had identical genetic characteristics as the organisms isolated from the participants exposed to that water while the remaining 3 MRSA were without matching nasal isolates from participants. The amount of S. aureus shed per person corresponded to 105 to 106 CFU per person per 15-minute bathing period, with 15 to 20% of this quantity testing positive for MRSA. This is the first report of a comparison of human colonizing organisms with bacteria from human exposed marine water attempting to confirm that participants shed their own colonizing MSSA and MRSA into their bathing milieu. These findings clearly demonstrate that adults and toddlers shed their colonizing organisms into marine waters and therefore can be sources of potentially pathogenic S. aureus and MRSA in recreational marine waters. Additional research is needed to evaluate recreational beaches and marine waters as potential exposure and transmission pathways for MRSA. JF - BMC Microbiology AU - Plano, Lisa RW AU - Garza, Anna C AU - Shibata, Tomoyuki AU - Elmir, Samir M AU - Kish, Jonathan AU - Sinigalliano, Christopher D AU - Gidley, Maribeth L AU - Miller, Gary AU - Withum, Kelly AU - Fleming, Lora E AU - Solo-Gabriele, Helena M AD - NSF-NIEHS Oceans and Human Health Center, University of Miami, Rosenstiel School for Marine and Atmospheric Sciences, 4600 Rickenbacker Causeway, EG 211 Key Biscayne, FL 33149 USA Y1 - 2011/01/06/ PY - 2011 DA - 2011 Jan 06 SP - 5 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 11 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Prisons KW - Beaches KW - Skin KW - Pediatrics KW - Drug resistance KW - Media (selective) KW - Opportunist infection KW - Methicillin KW - Recreation KW - Colony-forming cells KW - Polymerase chain reaction KW - Staphylococcus aureus KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907148973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Microbiology&rft.atitle=Shedding+of+Staphylococcus+aureus+and+methicillin-resistant+Staphylococcus+aureus+from+adult+and+pediatric+bathers+in+marine+waters&rft.au=Plano%2C+Lisa+RW%3BGarza%2C+Anna+C%3BShibata%2C+Tomoyuki%3BElmir%2C+Samir+M%3BKish%2C+Jonathan%3BSinigalliano%2C+Christopher+D%3BGidley%2C+Maribeth+L%3BMiller%2C+Gary%3BWithum%2C+Kelly%3BFleming%2C+Lora+E%3BSolo-Gabriele%2C+Helena+M&rft.aulast=Plano&rft.aufirst=Lisa&rft.date=2011-01-06&rft.volume=11&rft.issue=&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=BMC+Microbiology&rft.issn=1471-2180&rft_id=info:doi/10.1186%2F1471-2180-11-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Prisons; Beaches; Skin; Recreation; Methicillin; Pediatrics; Colony-forming cells; Drug resistance; Polymerase chain reaction; Media (selective); Opportunist infection; Staphylococcus aureus DO - http://dx.doi.org/10.1186/1471-2180-11-5 ER - TY - JOUR T1 - Identification of tolerated insertion sites in poliovirus non-structural proteins. AN - 815549463; 20971490 AB - Insertion of nucleotide sequences encoding "tags" that can be expressed in specific viral proteins during an infection is a useful strategy for purifying viral proteins and their functional complexes from infected cells and/or for visualizing the dynamics of their subcellular location over time. To identify regions in the poliovirus polyprotein that could potentially accommodate insertion of tags, transposon-mediated insertion mutagenesis was applied to the entire nonstructural protein-coding region of the poliovirus genome, followed by selection of genomes capable of generating infectious, viable viruses. This procedure allowed us to identify at least one site in each viral nonstructural protein, except protein 2C, in which a minimum of five amino acids could be inserted. The distribution of these sites is analyzed from the perspective of their protein structural context and from the perspective of virus evolution. Published by Elsevier Inc. JF - Virology AU - Teterina, Natalya L AU - Lauber, Chris AU - Jensen, Kenneth S AU - Levenson, Eric A AU - Gorbalenya, Alexander E AU - Ehrenfeld, Ellie AD - Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA. nteterina@niaid.nih.gov Y1 - 2011/01/05/ PY - 2011 DA - 2011 Jan 05 SP - 1 EP - 11 VL - 409 IS - 1 KW - DNA Transposable Elements KW - 0 KW - Viral Nonstructural Proteins KW - Index Medicus KW - Base Sequence KW - Models, Molecular KW - HeLa Cells KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Evolution, Molecular KW - Poliovirus -- chemistry KW - Viral Nonstructural Proteins -- genetics KW - Poliovirus -- physiology KW - Viral Nonstructural Proteins -- chemistry KW - Poliovirus -- metabolism KW - Poliovirus -- genetics KW - DNA Transposable Elements -- genetics KW - Viral Nonstructural Proteins -- metabolism KW - Mutagenesis, Insertional UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815549463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Identification+of+tolerated+insertion+sites+in+poliovirus+non-structural+proteins.&rft.au=Teterina%2C+Natalya+L%3BLauber%2C+Chris%3BJensen%2C+Kenneth+S%3BLevenson%2C+Eric+A%3BGorbalenya%2C+Alexander+E%3BEhrenfeld%2C+Ellie&rft.aulast=Teterina&rft.aufirst=Natalya&rft.date=2011-01-05&rft.volume=409&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=1096-0341&rft_id=info:doi/10.1016%2Fj.virol.2010.09.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-06 N1 - Date created - 2010-11-29 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NC_001490; RefSeq; NC_001859; NC_002058; NC_004441; NC_009996; NC_010415; NC_001430; NC_003988; AF499641; GENBANK; AY896766; AF499642; AF499643; AF546702; AF499640; AF499636; AF499637; AF499635; AF499638; DQ473512; AF499639; AF119796; D90457; K01392; M12197 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1986 Feb;83(3):571-5 [3003739] J Virol. 2000 Jul;74(14):6570-80 [10864671] J Virol. 1988 Nov;62(11):4016-21 [2845120] FEBS Lett. 1989 Jan 30;243(2):103-14 [2645167] Virus Res. 1999 Aug;62(2):159-68 [10507325] J Biol Chem. 2005 Mar 25;280(12):11520-7 [15654079] J Virol. 2005 Apr;79(8):5163-73 [15795300] J Virol. 2006 Feb;80(3):1451-62 [16415022] J Gen Virol. 2006 Feb;87(Pt 2):323-7 [16432018] J Virol. 2006 Jul;80(13):6637-47 [16775351] Peptides. 2006 Jul;27(7):1676-84 [16540201] Bioinformatics. 2006 Nov 1;22(21):2695-6 [16940322] J Virol. 2007 Apr;81(7):3583-96 [17251299] J Virol. 2007 May;81(10):5046-57 [17329335] J Virol. 2007 Nov;81(22):12543-53 [17804493] J Virol. 2008 Apr;82(7):3782-90 [18216106] J Virol. 2008 Oct;82(19):9458-64 [18632862] PLoS Pathog. 2008 Oct;4(10):e1000182 [18927624] Virus Res. 2009 Jul;143(1):114-24 [19463728] J Virol. 2009 Sep;83(18):9031-44 [19570872] J Virol. 2010 Feb;84(3):1477-88 [19939919] Antiviral Res. 2010 Aug;87(2):95-110 [20153379] J Biol Chem. 1994 Jan 7;269(1):66-70 [8276867] Nature. 1994 May 5;369(6475):72-6 [8164744] Cell. 1994 Jun 3;77(5):761-71 [7515772] Virology. 1994 Jul;202(1):129-45 [8009827] J Biol Chem. 1994 Oct 28;269(43):27015-20 [7929442] J Mol Biol. 1994 Nov 4;243(4):574-8 [7966282] Biochem Biophys Res Commun. 1995 Jan 5;206(1):64-76 [7818552] EMBO J. 1995 Mar 1;14(5):894-907 [7889939] J Mol Biol. 1997 Nov 14;273(5):1032-47 [9367789] Nature. 1998 May 21;393(6682):280-4 [9607767] J Virol. 2000 Oct;74(19):8953-65 [10982339] J Biol Chem. 2002 Oct 25;277(43):40434-41 [12183456] J Mol Biol. 2003 Jul 4;330(2):225-34 [12823963] Nucleic Acids Res. 2004;32(5):1792-7 [15034147] J Virol. 2004 Jul;78(14):7400-9 [15220413] EMBO J. 2004 Sep 1;23(17):3462-71 [15306852] Proc Natl Acad Sci U S A. 1983 Dec;80(24):7447-51 [6324172] Nucleic Acids Res. 2000 Mar 1;28(5):1067-77 [10666445] J Virol. 2000 Jul;74(14):6394-400 [10864650] J Virol. 1988 Aug;62(8):2922-8 [2839711] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.virol.2010.09.028 ER - TY - CPAPER T1 - Structural basis of voltage sensor function and pharmacology T2 - 2011 Annual Symposium of the Biochemical Society: Recent advances in membrane biochemistry AN - 1312986047; 6034690 JF - 2011 Annual Symposium of the Biochemical Society: Recent advances in membrane biochemistry AU - Swartz, Kenton Y1 - 2011/01/05/ PY - 2011 DA - 2011 Jan 05 KW - Pharmacology KW - Sensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312986047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Symposium+of+the+Biochemical+Society%3A+Recent+advances+in+membrane+biochemistry&rft.atitle=Structural+basis+of+voltage+sensor+function+and+pharmacology&rft.au=Swartz%2C+Kenton&rft.aulast=Swartz&rft.aufirst=Kenton&rft.date=2011-01-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Symposium+of+the+Biochemical+Society%3A+Recent+advances+in+membrane+biochemistry&rft.issn=&rft_id=info:doi/ L2 - http://www.biochemistry.org/Conferences/AllConferences/tabid/379/View/Programme/Filter/0%2012AS/MeetingNo/SA116/Default.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Assessing the accuracy and precision of musculoskeletal motion tracking using cine-PC MRI on a 3.0T platform AN - 883036289; 15313223 AB - The rising cost of musculoskeletal pathology, disease, and injury creates a pressing need for accurate and reliable methods to quantify 3D musculoskeletal motion, fostering a renewed interest in this area over the past few years. To date, cine-phase contrast (PC) MRI remains the only technique capable of non-invasively tracking in vivo 3D musculoskeletal motion during volitional activity, but current scan times are long on the 1.5T MR platform ([not, vert, similar]2.5 min or 75 movement cycles). With the clinical availability of higher field strength magnets (3.0T) that have increased signal-to-noise ratios, it is likely that scan times can be reduced while improving accuracy. Therefore, the purpose of this study is to validate cine-PC MRI on a 3.0T platform, in terms of accuracy, precision, and subject-repeatability, and to determine if scan time could be minimized. On the 3.0T platform it is possible to limit scan time to 2 min, with sub-millimeter accuracy (0.33 mm/0.97 degree ), excellent technique precision (0.18 degree ), and strong subject-repeatability (0.73 mm/1.10 degree ). This represents reduction in imaging time by 25% (42 s), a 50% improvement in accuracy, and a 72% improvement in technique precision over the original 1.5T platform. Scan time can be reduced to 1 min (30 movement cycles), but the improvements in accuracy are not as large. JF - Journal of Biomechanics AU - Behnam, Abrahm J AU - Herzka, Daniel A AU - Sheehan, Frances T AD - Rehabilitation Medicine Department, National Institutes of Health, Building 10 CRC RM 1-1469, 10 Center Drive MSC 1604, Bethesda, MD 20892-1604, USA Y1 - 2011/01/04/ PY - 2011 DA - 2011 Jan 04 SP - 193 EP - 197 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 44 IS - 1 SN - 0021-9290, 0021-9290 KW - Health & Safety Science Abstracts KW - Patella KW - Knee KW - Bone KW - Muscle KW - Validation KW - Phantom KW - Dynamic KW - Pathology KW - Injuries KW - biomechanics KW - musculoskeletal system KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883036289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomechanics&rft.atitle=Assessing+the+accuracy+and+precision+of+musculoskeletal+motion+tracking+using+cine-PC+MRI+on+a+3.0T+platform&rft.au=Behnam%2C+Abrahm+J%3BHerzka%2C+Daniel+A%3BSheehan%2C+Frances+T&rft.aulast=Behnam&rft.aufirst=Abrahm&rft.date=2011-01-04&rft.volume=44&rft.issue=1&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomechanics&rft.issn=00219290&rft_id=info:doi/10.1016%2Fj.jbiomech.2010.08.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Injuries; Pathology; biomechanics; musculoskeletal system DO - http://dx.doi.org/10.1016/j.jbiomech.2010.08.029 ER - TY - JOUR T1 - Interactions among genes, tumor biology and the environment in cancer health disparities: examining the evidence on a national and global scale AN - 968174401; 15609308 AB - Cancer incidence and mortality rates show great variations across nations and between population groups. These variations are largely explained by differences in age distribution, diet and lifestyle, access to health care, cultural barriers and exposure to carcinogens and pathogens. Cancers caused by infections are significantly more common in developing than developed countries, and they overproportionally affect immigrant populations in the USA and other countries. The global pattern of cancer is not stagnant. Instead, it is dynamic because of fluctuations in the age distribution of populations, improvements in cancer prevention and early detection in affluent countries and rapid changes in diet and lifestyle in parts of the world. For example, increased smoking rates have caused tobacco-induced cancers to rise in various Asian countries, whereas reduced smoking rates have caused these cancers to plateau or even begin to decline in Western Europe and North America. Some population groups experience a disproportionally high cancer burden. In the USA and the Caribbean, cancer incidence and mortality rates are excessively high in populations of African ancestry when compared with other population groups. The causes of this disparity are multifaceted and may include tumor biological and genetic factors and their interaction with the environment. In this review, we will discuss the magnitude and causes of global cancer health disparities and will, with a focus on African-Americans and selected cancer sites, evaluate the evidence that genetic and tumor biological factors contribute to existing cancer incidence and outcome differences among population groups in the USA. JF - Carcinogenesis AU - Wallace, Tiffany A AU - Martin, Damali N AU - Ambs, Stefan Y1 - 2011 PY - 2011 DA - 2011 SP - 1107 EP - 1121 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 32 IS - 8 SN - 0143-3334, 0143-3334 KW - Oncogenes & Growth Factors Abstracts; Genetics Abstracts; Health & Safety Science Abstracts KW - Age composition KW - ASW, Caribbean Sea KW - Cancer KW - H 11000:Diseases/Injuries/Trauma KW - B:26690 KW - G:07750 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968174401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Interactions+among+genes%2C+tumor+biology+and+the+environment+in+cancer+health+disparities%3A+examining+the+evidence+on+a+national+and+global+scale&rft.au=Wallace%2C+Tiffany+A%3BMartin%2C+Damali+N%3BAmbs%2C+Stefan&rft.aulast=Wallace&rft.aufirst=Tiffany&rft.date=2011-01-01&rft.volume=32&rft.issue=8&rft.spage=1107&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgr066 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Cancer; ASW, Caribbean Sea DO - http://dx.doi.org/10.1093/carcin/bgr066 ER - TY - JOUR T1 - Plasma Cannabinoid Pharmacokinetics following Controlled Oral Delta 9-Tetrahydrocannabinol and Oromucosal Cannabis Extract Administration AN - 968161888; 14169111 AB - BACKGROUND: Sativex registered , a cannabis extract oromucosal spray containing Delta 9-tetrahydrocannabinol (THC) and cannabidiol (CBD), is currently in phase III trials as an adjunct to opioids for cancer pain treatment, and recently received United Kingdom approval for treatment of spasticity. There are indications that CBD modulates THC's effects, but it is unclear if this is due to a pharmacokinetic and/or pharmacodynamic interaction. METHODS: Cannabis smokers provided written informed consent to participate in this randomized, controlled, double-blind, double-dummy institutional review board-approved study. Participants received 5 and 15 mg synthetic oral THC, low-dose (5.4 mg THC and 5.0 mg CBD) and high-dose (16.2 mg THC and 15.0 mg CBD) Sativex, and placebo over 5 sessions. CBD, THC, 11-hydroxy-THC, and 11-nor- 9-carboxy-THC were quantified in plasma by 2-dimensional GC-MS. Lower limits of quantification were less than or equal to 0.25 mu g/L. RESULTS: Nine cannabis smokers completed all 5 dosing sessions. Significant differences (P < 0.05) in maximum plasma concentrations (Cmax) and areas under the curve from 0-10.5 h postdose (AUC0 arrow right 10.5) for all analytes were found between low and high doses of synthetic THC and Sativex. There were no statistically significant differences in Cmax, time to maximum concentration or in the AUC0 arrow right 10.5 between similar oral THC and Sativex doses. Relative bioavailability was calculated to determine the relative rate and extent of THC absorption; 5 and 15 mg oral THC bioavailability was 92.6% (13.1%) and 98.8% (11.0%) of low- and high-dose Sativex, respectively. CONCLUSION: These data suggest that CBD modulation of THC's effects is not due to a pharmacokinetic interaction at these therapeutic doses. JF - Clinical Chemistry AU - Karschner, Erin L AU - Darwin, WDavid AU - Goodwin, Robert S AU - Wright, Stephen AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD Y1 - 2011 PY - 2011 DA - 2011 SP - 66 EP - 75 PB - American Association for Clinical Chemistry, Inc. VL - 57 IS - 1 SN - 0009-9147, 0009-9147 KW - Toxicology Abstracts KW - Data processing KW - Statistical analysis KW - Pain KW - Clinical trials KW - Cancer KW - Pharmacokinetics KW - Tetrahydrocannabinol KW - Bioavailability KW - Cannabinoids KW - Cannabis KW - Opioids KW - spasticity KW - Pharmacodynamics KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968161888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Chemistry&rft.atitle=Plasma+Cannabinoid+Pharmacokinetics+following+Controlled+Oral+Delta+9-Tetrahydrocannabinol+and+Oromucosal+Cannabis+Extract+Administration&rft.au=Karschner%2C+Erin+L%3BDarwin%2C+WDavid%3BGoodwin%2C+Robert+S%3BWright%2C+Stephen%3BHuestis%2C+Marilyn+A&rft.aulast=Karschner&rft.aufirst=Erin&rft.date=2011-01-01&rft.volume=57&rft.issue=1&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Clinical+Chemistry&rft.issn=00099147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2012-04-06 N1 - SubjectsTermNotLitGenreText - Data processing; Statistical analysis; Pain; Clinical trials; Pharmacokinetics; Cancer; Tetrahydrocannabinol; Bioavailability; Cannabinoids; Cannabis; Opioids; spasticity; Pharmacodynamics ER - TY - JOUR T1 - Effects of Carbidopa and Entacapone on the Metabolic Fate of the Norepinephrine Prodrug L-DOPS AN - 968161602; 14162241 AB - Background: L-threo-3,4-dihydroxyphenylserine (L-DOPS), a norepinephrine (NE) prodrug, is investigational for orthostatic hypotension, which occurs commonly in Parkinson's disease. Adjunctive anti-parkinsonian drugs might interact with L-DOPS. We tested whether L-aromatic amino-acid decarboxylase inhibition by carbidopa (CAR) attenuates L-DOPS conversion to NE and blocks the pressor effect of L-DOPS, whereas catechol-O-methyltransferase inhibition by entacapone (ENT) interferes with L-DOPS metabolism and augments the pressor effect. Methods: Twelve patients with autonomic failure took 400 mg of L-DOPS with 200 mg of placebo (PLA), CAR, or ENT on different days. Plasma L-DOPS, NE, and deaminated NE metabolites (dihydroxyphenylglycol [DHPG], dihydroxymandelic acid [DHMA]) were measured. Results: L-DOPS+PLA and L-DOPS+ENT increased systolic pressure similarly (by 27 plus or minus 8 and 24 plus or minus 9 mm Hg at 3 hours). L-DOPS+CAR did not increase pressure. The peak increase in plasma NE (0.57 plus or minus 0.11 nmol/L) averaged less than 1/15 000th that in L-DOPS and less than 1/35th that in DHPG+DHMA. CAR prevented and ENT augmented responses of plasma DHPG and DHMA to L-DOPS. Conclusions: After L-DOPS administration plasma, NE levels do not increase sufficiently to increase blood pressure. Pressor responses to L-DOPS seem to reflect NE produced extraneuronally that escapes extensive enzymatic deamination and O-methylation and evokes vasoconstriction before reaching the systemic circulation. JF - Journal of Clinical Pharmacology AU - Goldstein, David S AU - Holmes, Courtney AU - Sewell, LaToya AU - Pechnik, Sandra AU - Kopin, Irwin J AD - From the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda Maryland, goldsteind@ninds.nih.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 66 EP - 74 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 51 IS - 1 SN - 0091-2700, 0091-2700 KW - Toxicology Abstracts KW - Blood pressure KW - Catechol O-methyltransferase KW - Deamination KW - Drugs KW - Hypotension KW - Metabolites KW - Movement disorders KW - Neurodegenerative diseases KW - Norepinephrine KW - Parkinson's disease KW - Vasoconstriction KW - prodrugs KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968161602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Pharmacology&rft.atitle=Effects+of+Carbidopa+and+Entacapone+on+the+Metabolic+Fate+of+the+Norepinephrine+Prodrug+L-DOPS&rft.au=Goldstein%2C+David+S%3BHolmes%2C+Courtney%3BSewell%2C+LaToya%3BPechnik%2C+Sandra%3BKopin%2C+Irwin+J&rft.aulast=Goldstein&rft.aufirst=David&rft.date=2011-01-01&rft.volume=51&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/10.1016%2Fj.jadohealth.2010.08.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Number of references - 19 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Hypotension; Neurodegenerative diseases; Movement disorders; Catechol O-methyltransferase; prodrugs; Parkinson's disease; Deamination; Norepinephrine; Vasoconstriction; Metabolites; Drugs; Blood pressure DO - http://dx.doi.org/10.1177/0091270010363476 ER - TY - JOUR T1 - A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo AN - 968156209; 14183851 AB - In this study, a Cu super(2+) chelate of the novel thiosemicarbazone NSC 689534 was evaluated for in vitro and in vivo anti-cancer activity. Results demonstrated that NSC 689534 activity (low micromolar range) was enhanced four- to fivefold by copper chelation and completely attenuated by iron. Importantly, once formed, the NSC 689534/Cu super(2+) complex retained activity in the presence of additional iron or iron-containing biomolecules. NSC 689534/Cu super(2+) mediated its effects primarily through the induction of ROS, with depletion of cellular glutathione and protein thiols. Pretreatment of cells with the antioxidant N-acetyl-l-cysteine impaired activity, whereas NSC 689534/Cu super(2+) effectively synergized with the glutathione biosynthesis inhibitor buthionine sulfoximine. Microarray analysis of NSC 689534/Cu super(2+)-treated cells highlighted activation of pathways involved in oxidative and ER stress/UPR, autophagy, and metal metabolism. Further scrutiny of the role of ER stress and autophagy indicated that NSC 689534/Cu super(2+)-induced cell death was ER-stress dependent and autophagy independent. Last, NSC 689534/Cu super(2+) was shown to have activity in an HL60 xenograft model. These data suggest that NSC 689534/Cu super(2+) is a potent oxidative stress inducer worthy of further preclinical investigation. JF - Free Radical Biology and Medicine AU - Hancock, Chad N AU - Stockwin, Luke H AU - Han, Bingnan AU - Divelbiss, Raymond D AU - Jun, Jung Ho AU - Malhotra, Sanjay V AU - Hollingshead, Melinda G AU - Newton, Dianne L AD - Biological Testing Branch, Developmental Therapeutics Program, SAIC-Frederick, Frederick, MD 21702, USA, newtondianne@mail.nih.gov Y1 - 2011/01/01/ PY - 2011 DA - 2011 Jan 01 SP - 110 EP - 121 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 50 IS - 1 SN - 0891-5849, 0891-5849 KW - Toxicology Abstracts KW - Data processing KW - Antioxidants KW - Glutathione KW - Heavy metals KW - Chelation KW - Copper KW - Tumors KW - Buthionine sulfoximine KW - Cell death KW - N-Acetyl-L-cysteine KW - protein thiols KW - Oxidative stress KW - Xenografts KW - Chelates KW - Phagocytosis KW - Iron KW - Metabolism KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968156209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+Radical+Biology+and+Medicine&rft.atitle=A+copper+chelate+of+thiosemicarbazone+NSC+689534+induces+oxidative%2FER+stress+and+inhibits+tumor+growth+in+vitro+and+in+vivo&rft.au=Hancock%2C+Chad+N%3BStockwin%2C+Luke+H%3BHan%2C+Bingnan%3BDivelbiss%2C+Raymond+D%3BJun%2C+Jung+Ho%3BMalhotra%2C+Sanjay+V%3BHollingshead%2C+Melinda+G%3BNewton%2C+Dianne+L&rft.aulast=Hancock&rft.aufirst=Chad&rft.date=2011-01-01&rft.volume=50&rft.issue=1&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Free+Radical+Biology+and+Medicine&rft.issn=08915849&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2010.10.696 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2012-04-06 N1 - SubjectsTermNotLitGenreText - Antioxidants; Data processing; Heavy metals; Glutathione; Chelation; Tumors; Copper; Buthionine sulfoximine; Cell death; N-Acetyl-L-cysteine; protein thiols; Oxidative stress; Xenografts; Phagocytosis; Chelates; Iron; Metabolism DO - http://dx.doi.org/10.1016/j.freeradbiomed.2010.10.696 ER - TY - JOUR T1 - Making the Case for Talking to Patients about the Costs of End-of-Life Care AN - 964244024; 2011-177294 AB - Costs at the end of life disproportionately contribute to health care costs in the United States. Addressing these costs will therefore be an important component in making the U.S. health care system more financially sustainable. In this paper, we explore the moral justifications for having discussions of end-of-life costs in the doctor-patient encounter as part of an effort to control costs. As health care costs are partly shared through pooled resources, such as insurance and taxation, and partly borne by individuals through out-of-pocket expenses, we separate our defense for, and approach to, discussing both pooled and individual aspects of cost. We argue that there needs to be a shift away from formulating the options as a dichotomous choice of paying attention to end-of-life costs versus ignoring such costs. The question should be how personal costs will be managed and how societal expenditures should be allocated. These are issues that we believe patients care about and need to have addressed in a manner with which they are comfortable. Conversations about how money will be spent at the end of life should begin before the end is near. We propose discussing costs from the onset of chronic illness and incorporating financial issues in advance care planning. Through these approaches one can avoid abruptly and insensitively introducing financial issues at the very conclusion of a person's life when one would prefer to address the painful and important issues of spiritual and existential loss that are appropriately the focus when a person is dying. Adapted from the source document. JF - The Journal of Law, Medicine & Ethics AU - Donley, Greer AU - Danis, Marion AD - Fellow in the Department of Bioethics at the Clinical Center of the National Institutes of Health. Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 183 EP - 193 PB - Wiley-Blackwell, UK VL - 39 IS - 2 SN - 1073-1105, 1073-1105 KW - Law and ethics - Law and jurisprudence KW - Health conditions and policy - Medicine and health care KW - Law and ethics - Ethics KW - Economic conditions and policy - Economic theory KW - Science and technology policy - Biology and biotechnology KW - Business and service sector - Insurance KW - Health conditions and policy - Health and health policy KW - Banking and public and private finance - Money, currency, and financial instruments KW - Economic conditions and policy - Property and wealth KW - Banking and public and private finance - Taxation and tax policy KW - United States KW - Death KW - Money KW - Appropriations and expenditures KW - Bioethics KW - Health insurance KW - Patients KW - Taxation KW - Cost KW - Medicine KW - Law KW - Medical service KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964244024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Law%2C+Medicine+%26+Ethics&rft.atitle=Making+the+Case+for+Talking+to+Patients+about+the+Costs+of+End-of-Life+Care&rft.au=Donley%2C+Greer%3BDanis%2C+Marion&rft.aulast=Donley&rft.aufirst=Greer&rft.date=2011-01-01&rft.volume=39&rft.issue=2&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Law%2C+Medicine+%26+Ethics&rft.issn=10731105&rft_id=info:doi/10.1111%2Fj.1748-720X.2011.00587.x LA - English DB - PAIS Index N1 - Date revised - 2012-04-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Law; Medicine; Bioethics; Cost; Medical service; Patients; United States; Appropriations and expenditures; Death; Health insurance; Money; Taxation DO - http://dx.doi.org/10.1111/j.1748-720X.2011.00587.x ER - TY - JOUR T1 - Kidney Stem Cells Found in Adult Zebrafish AN - 954650399; 14602679 AB - Recently in Nature, Davidson and coworkers (Diep et al., 2011) identified nephron progenitors/stem cells located at the point of fusion with the pronephric tubules in adult zebrafish. Clumps of progenitors give rise to functional nephrons after serial transplantation, demonstrating the ability of tissue stem cells to regenerate damaged kidney structures. JF - Cell Stem Cell AU - Zeng, Xiankun AU - Hou, Steven X Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 247 EP - 249 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA VL - 8 IS - 3 SN - 1934-5909, 1934-5909 KW - ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Danio rerio KW - Stem cells KW - Nephrons KW - Transplantation KW - Kidney KW - Kidneys KW - Freshwater KW - Freshwater fish KW - Tubules KW - Q1 08344:Reproduction and development KW - F 06940:Fish Immunity KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954650399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Stem+Cell&rft.atitle=Kidney+Stem+Cells+Found+in+Adult+Zebrafish&rft.au=Zeng%2C+Xiankun%3BHou%2C+Steven+X&rft.aulast=Zeng&rft.aufirst=Xiankun&rft.date=2011-01-01&rft.volume=8&rft.issue=3&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Cell+Stem+Cell&rft.issn=19345909&rft_id=info:doi/10.1016%2Fj.stem.2011.02.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Transplantation; Kidneys; Freshwater fish; Nephrons; Stem cells; Kidney; Tubules; Danio rerio; Freshwater DO - http://dx.doi.org/10.1016/j.stem.2011.02.008 ER - TY - JOUR T1 - Lognormal Distribution of Cellular Uptake of Radiopharmaceuticals: Implications for Biologic Response in Cancer Treatment AN - 954643620; 14592734 JF - Journal of Nuclear Medicine AU - Zanotti-Fregonara, Paolo AU - Hindie, Elif AD - National Institutes of Health Bethesda, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 501 EP - 503 PB - Society of Nuclear Medicine VL - 52 IS - 4 SN - 0161-5505, 0161-5505 KW - Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954643620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nuclear+Medicine&rft.atitle=Lognormal+Distribution+of+Cellular+Uptake+of+Radiopharmaceuticals%3A+Implications+for+Biologic+Response+in+Cancer+Treatment&rft.au=Zanotti-Fregonara%2C+Paolo%3BHindie%2C+Elif&rft.aulast=Zanotti-Fregonara&rft.aufirst=Paolo&rft.date=2011-01-01&rft.volume=52&rft.issue=4&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 ER - TY - JOUR T1 - Avoiding Barriers to PET Radioligand Development: Cellular Assays of Brain Efflux Transporters AN - 954624307; 14405559 JF - Journal of Nuclear Medicine AU - Hall, Matthew D AU - Pike, Victor W AD - National Institutes of Health Bethesda, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 338 EP - 340 PB - Society of Nuclear Medicine VL - 52 IS - 3 SN - 0161-5505, 0161-5505 KW - Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954624307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nuclear+Medicine&rft.atitle=Avoiding+Barriers+to+PET+Radioligand+Development%3A+Cellular+Assays+of+Brain+Efflux+Transporters&rft.au=Hall%2C+Matthew+D%3BPike%2C+Victor+W&rft.aulast=Hall&rft.aufirst=Matthew&rft.date=2011-01-01&rft.volume=52&rft.issue=3&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 ER - TY - JOUR T1 - 18F-FPPRGD2 and 18F-FDG PET of Response to Abraxane Therapy AN - 954617608; 14169958 AB - Abraxane (nanoparticle albumin-bound paclitaxel) is an anticancer drug approved by the Food and Drug Administration. However, the mechanism of action of Abraxane is complex, and no established biomarker is available to accurately monitor its treatment outcomes. The aim of this study was to investigate whether the integrin-specific PET tracer 18F-FPPRGD2 (investigational new drug 104150) can be used to monitor early response of tumors to Abraxane therapy. METHODS: Orthotopic MDA-MB-435 breast cancer mice were treated with Abraxane (25 mg/kg every other day, 3 doses) or phosphate-buffered saline. Tumor volume was monitored by caliper measurement. PET scans were obtained before and at different times after the start of treatment (days 0, 3, 7, 14, and 21) using 18F-FPPRGD2 and 18F-FDG. The tumoricidal effect was also assessed ex vivo by immunohistochemistry. RESULTS: Abraxane treatment inhibited the tumor growth, and a significant difference in tumor volume could be seen at day 5 after the initiation of treatment. The tumor uptake of 18F-FPPRGD2 in the Abraxane-treated group was significantly lower on days 3 and 7 than at baseline but returned to the baseline level at days 14 and 21, indicative of relapse of the tumors after the treatment was halted. Immunohistologic staining confirmed that the change of 18F-FPPRGD2 uptake correlated with the variation of integrin level in the tumor vasculature induced by Abraxane treatment. No significant change of tumor (rather than vascular) integrin expression was observed throughout the study. No significant decrease of 18F-FDG uptake was found between the treated and the control tumors on days 3, 14, and 21, although an increase in 18F-FDG tumor uptake of treated mice, as compared with the control mice, was found on day 7. The increase of 18F-FDG on day 7 was related to the inflammatory response during therapy. CONCLUSION: Abraxane-mediated downregulation of integrin alpha v beta 3 expression on tumor endothelial cells can be quantitatively visualized by PET. The change of integrin expression precedes that of tumor size. Consequently, 18F-FPPRGD2 PET is superior to 18F-FDG PET in monitoring early response to treatment, favoring its potential clinical translation. JF - Journal of Nuclear Medicine AU - Sun, Xilin AU - Yan, Yongjun AU - Liu, Shuanglong AU - Cao, Qizhen AU - Yang, Min AU - Neamati, Nouri AU - Shen, Baozhong AU - Niu, Gang AU - Chen, Xiaoyuan AD - Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 140 EP - 146 PB - Society of Nuclear Medicine VL - 52 IS - 1 SN - 0161-5505, 0161-5505 KW - Biotechnology and Bioengineering Abstracts KW - Translation KW - Tumors KW - Antitumor agents KW - biomarkers KW - Inflammation KW - Endothelial cells KW - Tracers KW - Integrins KW - Paclitaxel KW - Positron emission tomography KW - Breast cancer KW - Nuclear medicine KW - Immunohistochemistry KW - nanoparticles KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954617608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=dnaX36+Mutator+of+Escherichia+coli%3A+Effects+of+the+Subunit+of+the+DNA+Polymerase+III+Holoenzyme+on+Chromosomal+DNA+Replication+Fidelity&rft.au=Gawel%2C+Damian%3BJonczyk%2C+Piotr%3BFijalkowska%2C+Iwona+J%3BSchaaper%2C+Roel+M&rft.aulast=Gawel&rft.aufirst=Damian&rft.date=2011-01-01&rft.volume=193&rft.issue=1&rft.spage=296&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01191-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Translation; Tumors; biomarkers; Antitumor agents; Inflammation; Endothelial cells; Tracers; Paclitaxel; Integrins; Positron emission tomography; Nuclear medicine; Breast cancer; nanoparticles; Immunohistochemistry ER - TY - JOUR T1 - A regressed phase analysis for coupled joint systems AN - 954610240; 14183885 AB - This study aims to address shortcomings of the relative phase analysis, a widely used method for assessment of coupling among joints of the lower limb. Goniometric data from 15 individuals with spastic diplegic cerebral palsy were recorded from the hip and knee joints during ambulation on a flat surface, and from a single healthy individual with no known motor impairment, over at least 10 gait cycles. The minimum relative phase (MRP) revealed substantial disparity in the timing and severity of the instance of maximum coupling, depending on which reference frame was selected: MRP sub(knee-hip) differed from MRP sub(hip-knee) by 16.1 +/- 14% of gait cycle and 50.6 +/- 77% difference in scale. Additionally, several relative phase portraits contained discontinuities which may contribute to error in phase feature extraction. These vagaries can be attributed to the predication of relative phase analysis on a transformation into the velocity-position phase plane, and the extraction of phase angle by the discontinuous arctangent operator. Here, an alternative phase analysis is proposed, wherein kinematic data is transformed into a profile of joint coupling across the entire gait cycle. By comparing joint velocities directly via a standard linear regression in the velocity-velocity phase plane, this regressed phase analysis provides several key advantages over relative phase analysis including continuity, commutativity between reference frames, and generalizability to many-joint systems. JF - Gait & Posture AU - Wininger, Michael AD - Department of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USA, michael.wininger@nih.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 136 EP - 139 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 33 IS - 1 SN - 0966-6362, 0966-6362 KW - Physical Education Index KW - Evaluation KW - Kinematics KW - Analysis KW - Objectives KW - Cerebral palsy KW - Velocity KW - Gait KW - Hips KW - Joints KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954610240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gait+%26+Posture&rft.atitle=A+regressed+phase+analysis+for+coupled+joint+systems&rft.au=Wininger%2C+Michael&rft.aulast=Wininger&rft.aufirst=Michael&rft.date=2011-01-01&rft.volume=33&rft.issue=1&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=Gait+%26+Posture&rft.issn=09666362&rft_id=info:doi/10.1016%2Fj.gaitpost.2010.09.011 LA - English DB - Physical Education Index N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Evaluation; Kinematics; Objectives; Analysis; Cerebral palsy; Velocity; Gait; Hips; Joints DO - http://dx.doi.org/10.1016/j.gaitpost.2010.09.011 ER - TY - JOUR T1 - Receiver-operating characteristics of adiposity for metabolic syndrome: the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study AN - 954599139; 14296984 AB - To assess the predictive values of various adiposity indices for metabolic syndrome (MetS) among adults using baseline data from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) cohort. In a cross-sectional study, BMI, waist circumference (WC), body composition by dual-energy X-ray absorptiometry (DEXA) and metabolic risk factors such as TAG, HDL cholesterol, blood pressure, fasting glucose and insulin, uric acid and C-reactive protein were measured. Receiver-operating characteristic (ROC) curves and logistic regression analyses were conducted. Baltimore, Maryland. White and African-American US adults (n 1981), aged 30-64 years. In predicting risk of MetS using obesity-independent National Cholesterol Education Program Adult Treatment Panel III criteria, percentage total body fat mass (TtFM) assessed using DEXA measuring overall adiposity had no added value over WC. This was true among both men (area under the ROC curve (AUC) = 0.680 v . 0.733 for TtFM and WC, respectively; P < 0.05) and women (AUC = 0.581 v . 0.686). Percentage rib fat mass (RbFM) was superior to TtFM only in women for MetS (AUC = 0.701 and 0.581 for RbFM and TtFM, respectively; P < 0.05), particularly among African-American women. Elevated percentage leg fat mass (LgFM) was protective against MetS among African-American men. Among white men, BMI was inferior to WC in predicting MetS. Optimal WC cut-off points varied across ethnic-sex groups and differed from those recommended by the National Institutes of Health/North American Association for the Study of Obesity. The study provides evidence that WC is among the most powerful tools to predict MetS, and that optimal cut-off points for various indices including WC may differ by sex and race. JF - Public Health Nutrition AU - Beydoun, May A AU - Fanelli Kuczmarski, Marie T AU - Wang, Youfa AU - Mason, Marc A AU - Evans, Michele K AU - Zonderman, Alan B AD - Department of Health , Nutrition and Exercise Sciences , University of Delaware , Newark , DE , USA, baydounm@mail.nih.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 77 EP - 92 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU UK VL - 14 IS - 1 SN - 1368-9800, 1368-9800 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Education KW - USA, Maryland, Baltimore KW - Ethnic groups KW - H 12000:Epidemiology and Public Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954599139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Nutrition&rft.atitle=Receiver-operating+characteristics+of+adiposity+for+metabolic+syndrome%3A+the+Healthy+Aging+in+Neighborhoods+of+Diversity+across+the+Life+Span+%28HANDLS%29+study&rft.au=Beydoun%2C+May+A%3BFanelli+Kuczmarski%2C+Marie+T%3BWang%2C+Youfa%3BMason%2C+Marc+A%3BEvans%2C+Michele+K%3BZonderman%2C+Alan+B&rft.aulast=Beydoun&rft.aufirst=May&rft.date=2011-01-01&rft.volume=14&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Public+Health+Nutrition&rft.issn=13689800&rft_id=info:doi/10.1017%2FS1368980010002648 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Ethnic groups; USA, Maryland, Baltimore DO - http://dx.doi.org/10.1017/S1368980010002648 ER - TY - JOUR T1 - Diminished Sensitivity to Sad Facial Expressions in High Functioning Autism Spectrum Disorders is Associated with Symptomatology and Adaptive Functioning AN - 925742347; 201205974 AB - Prior studies implicate facial emotion recognition (FER) difficulties among individuals with autism spectrum disorders (ASD); however, many investigations focus on FER accuracy alone and few examine ecological validity through links with everyday functioning. We compared FER accuracy and perceptual sensitivity (from neutral to full expression) between 42 adolescents with high functioning (IQ > 80) ASD and 31 typically developing adolescents (matched on age, IQ, sex ratio) across six basic emotions and examined links between FER and symptomatology/adaptive functioning within the ASD group. Adolescents with ASD required more intense facial expressions for accurate emotion identification. Controlling for this overall group difference revealed particularly diminished sensitivity to sad facial expressions in ASD, which was uniquely correlated with ratings of autism-related behavior and adaptive functioning. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Wallace, Gregory L AU - Case, Laura K AU - Harms, Madeline B AU - Silvers, Jennifer A AU - Kenworthy, Lauren AU - Martin, Alex AD - Laboratory of Brain & Cognition, National Institute of Mental Health, 10 Center Drive, Room 4C104, MSC 1366, Bethesda, MD, 20892-1366, USA gregwallace@mail.nih.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 1475 EP - 1486 PB - Springer, Dordrecht The Netherlands VL - 41 IS - 11 SN - 0162-3257, 0162-3257 KW - High functioning KW - Emotions KW - Facial expressions KW - Adaptive behaviour KW - Adolescents KW - Autistic spectrum disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925742347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Diminished+Sensitivity+to+Sad+Facial+Expressions+in+High+Functioning+Autism+Spectrum+Disorders+is+Associated+with+Symptomatology+and+Adaptive+Functioning&rft.au=Wallace%2C+Gregory+L%3BCase%2C+Laura+K%3BHarms%2C+Madeline+B%3BSilvers%2C+Jennifer+A%3BKenworthy%2C+Lauren%3BMartin%2C+Alex&rft.aulast=Wallace&rft.aufirst=Gregory&rft.date=2011-01-01&rft.volume=41&rft.issue=11&rft.spage=1475&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-010-1170-0 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Autistic spectrum disorders; Adolescents; Facial expressions; Adaptive behaviour; Emotions; High functioning DO - http://dx.doi.org/10.1007/s10803-010-1170-0 ER - TY - JOUR T1 - The Effect of Passengers and Risk-Taking Friends on Risky Driving and Crashes/Near Crashes Among Novice Teenagers AN - 925742095; 201205623 AB - Purpose: The high crash rates of novice teenage drivers are thought to be caused by inexperience and risky driving behavior, exacerbated by passengers, driving at night, and other complex driving conditions. This study examined factors associated with crash/near crash and risky driving rates among novice teenagers, including driving at night versus day, passenger presence and characteristics, and driver psychosocial factors. Method: The vehicles of 42 newly licensed teenage drivers were equipped with recording systems that collected data on driving performance and occupant characteristics during their first 18 months of licensure. Survey data were collected at four measurement times. Poisson regression models with random effects were used to analyze crash/near crash and elevated gravitational force event rates (i.e., risky driving); incident rate ratios measured associations with covariates. Results: Crash/near crash rates among novice teenagers were 75% lower in the presence of adult passengers and 96% higher among those teenagers with risky friends. Teenage risky driving was 67% lower with adult passengers, 18% lower with teenage passengers; 20% lower during early night than day; and 109% higher among teens with relatively more risky friends. Conclusions: The low rate of risky driving in the presence of adult passengers suggests that teens can drive in a less risky manner. The higher rate of risky driving among those with risky friends suggests that risky driving may be socially influenced. [Copyright The Society for Adolescent Medicine; published by Elsevier Inc.] JF - Journal of Adolescent Health AU - Simons-Morton, Bruce G AU - Ouimet, Marie Claude AU - Zhang, Zhiwei AU - Klauer, Sheila E AU - Lee, Suzanne E AU - Wang, Jing AU - Chen, Rusan AU - Albert, Paul AU - Dingus, Thomas A AD - Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 587 EP - 593 PB - Elsevier, New York NY VL - 49 IS - 6 SN - 1054-139X, 1054-139X KW - Adolescence Risk taking Accidents Learning to drive Kinematic Expertise KW - Passengers KW - Driving KW - Drivers KW - Friends KW - Novices KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925742095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=The+Effect+of+Passengers+and+Risk-Taking+Friends+on+Risky+Driving+and+Crashes%2FNear+Crashes+Among+Novice+Teenagers&rft.au=Simons-Morton%2C+Bruce+G%3BOuimet%2C+Marie+Claude%3BZhang%2C+Zhiwei%3BKlauer%2C+Sheila+E%3BLee%2C+Suzanne+E%3BWang%2C+Jing%3BChen%2C+Rusan%3BAlbert%2C+Paul%3BDingus%2C+Thomas+A&rft.aulast=Simons-Morton&rft.aufirst=Bruce&rft.date=2011-01-01&rft.volume=49&rft.issue=6&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/10.1016%2Fj.jadohealth.2011.02.009 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JAHCD9 N1 - SubjectsTermNotLitGenreText - Driving; Passengers; Adolescents; Novices; Friends; Drivers DO - http://dx.doi.org/10.1016/j.jadohealth.2011.02.009 ER - TY - JOUR T1 - 2011 Special Libraries Association Conference AN - 925709603; 201201992 AB - The 2011 Special Libraries Association Annual Conference took place June 12-15 in Philadelphia, Pennsylvania. The conference's theme was "Future Ready," and it featured a diverse array of programming for information professionals. Following are summaries from four of the conference sessions. [Copyright Elsevier Inc.] JF - Serials Review AU - Fernandez, Michael AD - National Library of Medicine, Bethesda, MD 20894, USA fernmich@mail.nlm.nih.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 313 EP - 314 PB - Elsevier, San Diego CA VL - 37 IS - 4 SN - 0098-7913, 0098-7913 KW - Conferences KW - Library associations KW - Special libraries KW - article KW - 1.12: LIS - CONFERENCES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925709603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Serials+Review&rft.atitle=2011+Special+Libraries+Association+Conference&rft.au=Fernandez%2C+Michael&rft.aulast=Fernandez&rft.aufirst=Michael&rft.date=2011-01-01&rft.volume=37&rft.issue=4&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Serials+Review&rft.issn=00987913&rft_id=info:doi/10.1016%2Fj.serrev.2011.09.004 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Conferences; Special libraries; Library associations DO - http://dx.doi.org/10.1016/j.serrev.2011.09.004 ER - TY - JOUR T1 - Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans AN - 923207680; 15014175 AB - BACKGROUND: Studies in mice indicate that the gut microbiome influences both sides of the energy-balance equation by contributing to nutrient absorption and regulating host genes that affect adiposity. However, it remains uncertain as to what extent gut microbiota are an important regulator of nutrient absorption in humans. OBJECTIVE: With the use of a carefully monitored inpatient study cohort, we tested how gut bacterial community structure is affected by altering the nutrient load in lean and obese individuals and whether their microbiota are correlated with the efficiency of dietary energy harvest. DESIGN: We investigated dynamic changes of gut microbiota during diets that varied in caloric content (2400 compared with 3400 kcal/d) by pyrosequencing bacterial 16S ribosomal RNA (rRNA) genes present in the feces of 12 lean and 9 obese individuals and by measuring ingested and stool calories with the use of bomb calorimetry. RESULTS: The alteration of the nutrient load induced rapid changes in the gut microbiota. These changes were directly correlated with stool energy loss in lean individuals such that a 20% increase in Firmicutes and a corresponding decrease in Bacteroidetes were associated with an increased energy harvest of approximately 150 kcal. A high degree of overfeeding in lean individuals was accompanied by a greater fractional decrease in stool energy loss. CONCLUSIONS: These results show that the nutrient load is a key variable that can influence the gut (fecal) bacterial community structure over short time scales. Furthermore, the observed associations between gut microbes and nutrient absorption indicate a possible role of the human gut microbiota in the regulation of the nutrient harvest. This trial was registered at clinicaltrials.gov as NCT00414063. JF - American Journal of Clinical Nutrition AU - Jumpertz, Reiner AU - Le, Duc Son AU - Turnbaugh, Peter J AU - Trinidad, Cathy AU - Bogardus, Clifton AU - Gordon, Jeffrey I AU - Krakoff, Jonathan AD - From the Obesity and Diabetes Clinical Research Section, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Phoenix, AZ (RJ, DSL, CT, CB, and JK) Y1 - 2011 PY - 2011 DA - 2011 SP - 58 EP - 65 PB - American Society for Clinical Nutrition, 3247 Meyer Hall, University of California Davis CA 95616-8790 USA VL - 94 IS - 1 SN - 0002-9165, 0002-9165 KW - Microbiology Abstracts B: Bacteriology KW - Obesity KW - Mathematical models KW - Calories KW - Nutrients KW - Firmicutes KW - Digestive tract KW - Community structure KW - Energy KW - Calorimetry KW - Adipose tissue KW - Feces KW - rRNA 16S KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/923207680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Clinical+Nutrition&rft.atitle=Energy-balance+studies+reveal+associations+between+gut+microbes%2C+caloric+load%2C+and+nutrient+absorption+in+humans&rft.au=Jumpertz%2C+Reiner%3BLe%2C+Duc+Son%3BTurnbaugh%2C+Peter+J%3BTrinidad%2C+Cathy%3BBogardus%2C+Clifton%3BGordon%2C+Jeffrey+I%3BKrakoff%2C+Jonathan&rft.aulast=Jumpertz&rft.aufirst=Reiner&rft.date=2011-01-01&rft.volume=94&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Clinical+Nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Obesity; Calories; Mathematical models; Digestive tract; Community structure; Energy; Adipose tissue; Calorimetry; Nutrients; Feces; rRNA 16S; Firmicutes ER - TY - JOUR T1 - The NIAID Division of AIDS enterprise information system: integrated decision support for global clinical research programs AN - 920788193; 16166519 AB - The National Institute of Allergy and Infectious Diseases (NIAID) Division of AIDS (DAIDS) Enterprise Information System (DAIDS-ES) is a web-based system that supports NIAID in the scientific, strategic, and tactical management of its global clinical research programs for HIV/AIDS vaccines, prevention, and therapeutics. Different from most commercial clinical trials information systems, which are typically protocol-driven, the DAIDS-ES was built to exchange information with those types of systems and integrate it in ways that help scientific program directors lead the research effort and keep pace with the complex and ever-changing global HIV/AIDS pandemic. Whereas commercially available clinical trials support systems are not usually disease-focused, DAIDS-ES was specifically designed to capture and incorporate unique scientific, demographic, and logistical aspects of HIV/AIDS treatment, prevention, and vaccine research in order to provide a rich source of information to guide informed decision-making. Sharing data across its internal components and with external systems, using defined vocabularies, open standards and flexible interfaces, the DAIDS-ES enables NIAID, its global collaborators and stakeholders, access to timely, quality information about NIAID-supported clinical trials which is utilized to: (1) analyze the research portfolio, assess capacity, identify opportunities, and avoid redundancies; (2) help support study safety, quality, ethics, and regulatory compliance; (3) conduct evidence-based policy analysis and business process re-engineering for improved efficiency. This report summarizes how the DAIDS-ES was conceptualized, how it differs from typical clinical trial support systems, the rationale for key design choices, and examples of how it is being used to advance the efficiency and effectiveness of NIAID's HIV/AIDS clinical research programs. JF - Journal of the American Medical Informatics Association AU - Kagan, Jonathan M AU - Gupta, Nitin AU - Varghese, Suresh AU - Virkar, Hemant AD - Division of Clinical Research, Department of Health & Human Services, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2011 PY - 2011 DA - 2011 SP - i161 EP - i165 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Bethesda MD 20814 United States VL - 18 SN - 1067-5027, 1067-5027 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Acquired immune deficiency syndrome KW - Data processing KW - Informatics KW - Clinical trials KW - Demography KW - Decision making KW - Hypersensitivity KW - pandemics KW - Infectious diseases KW - Human immunodeficiency virus KW - Ethics KW - Vaccines KW - Research programs KW - Information systems KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920788193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=The+NIAID+Division+of+AIDS+enterprise+information+system%3A+integrated+decision+support+for+global+clinical+research+programs&rft.au=Kagan%2C+Jonathan+M%3BGupta%2C+Nitin%3BVarghese%2C+Suresh%3BVirkar%2C+Hemant&rft.aulast=Kagan&rft.aufirst=Jonathan&rft.date=2011-01-01&rft.volume=18&rft.issue=&rft.spage=i161&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Data processing; Informatics; Clinical trials; Demography; Decision making; pandemics; Hypersensitivity; Infectious diseases; Ethics; Vaccines; Research programs; Information systems; Human immunodeficiency virus ER - TY - JOUR T1 - Causes, risks, and probabilities: Probabilistic concepts of causation in chronic disease epidemiology AN - 919970828; 201202689 AB - Identifying and understanding causes of disease is arguably the central aim of the discipline of epidemiology. However, while the discipline has matured over the past sixty years, developing a battery of quantitative tools and methods for data analysis, the discipline of epidemiology lacks an explicit, shared theoretical account of causation. Moreover, some epidemiologists exhibit discomfort with the concept of causation itself, concerned that it creates more confusion than clarity. This paper describes how, during the post-war period, epidemiologists began to think about causation in new ways as they encountered novel challenges in studying chronic diseases. The epidemiologic evidence linking cigarette smoking and lung cancer in the 1950s provided a focus for debates over causation. While some epidemiologists embraced probabilistic concepts of cause and effect, others maintained that causal mechanisms must ultimately be deterministic. The tension between probabilistic risk factors and deterministic causal mechanisms continues to haunt epidemiology today. [Copyright Elsevier B.V.] JF - Preventive Medicine AU - Parascandola, Mark AD - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA paramark@mail.nih.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 232 EP - 234 PB - Elsevier Ltd, The Netherlands VL - 53 IS - 4-5 SN - 0091-7435, 0091-7435 KW - Epidemiology Causation Causal inference Cancer Prevention KW - Smoking KW - Chronic sickness KW - Epidemiology KW - Confusion KW - Discipline KW - Lung cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919970828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventive+Medicine&rft.atitle=Causes%2C+risks%2C+and+probabilities%3A+Probabilistic+concepts+of+causation+in+chronic+disease+epidemiology&rft.au=Parascandola%2C+Mark&rft.aulast=Parascandola&rft.aufirst=Mark&rft.date=2011-01-01&rft.volume=53&rft.issue=4-5&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=Preventive+Medicine&rft.issn=00917435&rft_id=info:doi/10.1016%2Fj.ypmed.2011.09.007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Epidemiology; Discipline; Chronic sickness; Smoking; Lung cancer; Confusion DO - http://dx.doi.org/10.1016/j.ypmed.2011.09.007 ER - TY - JOUR T1 - Public Health Surveillance in the Context of Growing Sources of Health Data: A Commentary AN - 919970096; 201201957 AB - Discusses what the core focus of American public health should be after a century of shifting priorities from funding institutions, changes in health knowledge from fundamental biological discovery, and alterations in public and political mood. It focuses on a "fourth paradigm" in science, a logical progression from experimentation to theory and then to simulation, an era in science when advances in networking and information technology will allow for data-intensive surveillance and discovery to co-occur. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Hesse, Bradford W AD - National Cancer Institute, NIH, Bethesda, Maryland hesseb@mail.nih.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 648 EP - 649 PB - Elsevier Science, New York NY VL - 41 IS - 6 SN - 0749-3797, 0749-3797 KW - Simulation KW - Information technology KW - Discovery KW - Health information KW - Surveillance KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919970096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Public+Health+Surveillance+in+the+Context+of+Growing+Sources+of+Health+Data%3A+A+Commentary&rft.au=Hesse%2C+Bradford+W&rft.aulast=Hesse&rft.aufirst=Bradford&rft.date=2011-01-01&rft.volume=41&rft.issue=6&rft.spage=648&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2011.09.016 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Public health; Surveillance; Health information; Discovery; Information technology; Simulation DO - http://dx.doi.org/10.1016/j.amepre.2011.09.016 ER - TY - JOUR T1 - Personality Traits Prospectively Predict Verbal Fluency in a Lifespan Sample AN - 919970062; 201203130 AB - In a community-dwelling sample (N = 4,790; age range 14-94), we examined whether personality traits prospectively predicted performance on a verbal fluency task. Open, extraverted, and emotionally stable participants had better verbal fluency. At the facet level, dispositionally happy and self-disciplined participants retrieved more words; those prone to anxiety and depression and those who were deliberative retrieved fewer words. Education moderated the association between conscientiousness and fluency such that participants with lower education performed better on the fluency task if they were also conscientious. Age was not a moderator at the domain level, indicating that the personality-fluency associations were consistent across the life span. A disposition toward emotional vulnerability and being less open, less happy, and undisciplined may be detrimental to cognitive performance. [Copyright American Psychological Association] JF - Psychology and Aging AU - Sutin, Angelina R AU - Terracciano, Antonio AU - Kitner-Triolo, Melissa H AU - Uda, Manuela AU - Schlessinger, David AU - Zonderman, Alan B AD - Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland sutina@mail.nih.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 994 EP - 999 PB - American Psychological Association, Washington DC VL - 26 IS - 4 SN - 0882-7974, 0882-7974 KW - Task performance KW - Life span KW - Personality KW - Moderators KW - Anxiety-Depression KW - Fluency KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919970062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+and+Aging&rft.atitle=Personality+Traits+Prospectively+Predict+Verbal+Fluency+in+a+Lifespan+Sample&rft.au=Sutin%2C+Angelina+R%3BTerracciano%2C+Antonio%3BKitner-Triolo%2C+Melissa+H%3BUda%2C+Manuela%3BSchlessinger%2C+David%3BZonderman%2C+Alan+B&rft.aulast=Sutin&rft.aufirst=Angelina&rft.date=2011-01-01&rft.volume=26&rft.issue=4&rft.spage=994&rft.isbn=&rft.btitle=&rft.title=Psychology+and+Aging&rft.issn=08827974&rft_id=info:doi/10.1037%2Fa0024276 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PAGIEL N1 - SubjectsTermNotLitGenreText - Fluency; Life span; Task performance; Personality; Anxiety-Depression; Moderators DO - http://dx.doi.org/10.1037/a0024276 ER - TY - JOUR T1 - Convergence and nonconvergence in the quality of adolescent relationships and its association with adolescent adjustment and young-adult relationship quality AN - 919969931; 201202056 AB - With the aim of identifying and examining both convergence (matched relationship quality across one's set of relationships) and nonconvergence (mixed relationship quality across one's set of relationships), the present study used a pattern-centered approach to examine the different ways adolescent relationships pattern together among a large, national sample of U.S. adolescents (aged 13-19). The study also examined how adolescent adjustment and young-adult relationship quality varied across the different relationship patterns or constellations. The current study used latent class analysis and data from Add Health (n = 4,233), a national U.S. longitudinal study that spans adolescence and young adulthood, to uncover heterogeneity in adolescent relations with parents, friends, romantic partners, peers, and teachers. As predicted, patterns of both convergence and nonconvergence were found, though patterns of nonconvergence were more common than expected. Some patterns of nonconvergence appear more stable (i.e., similar pattern found during both adolescence and young adulthood) than others. Also, no "high" converging pattern was found, indicating that few adolescents have "first-rate" relations in every relational domain. Adapted from the source document. JF - International Journal of Behavioral Development AU - Jager, Justin AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, USA jagerjo@mail.nih.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 497 EP - 506 PB - Sage Publications, Thousand Oaks, CA VL - 35 IS - 6 SN - 0165-0254, 0165-0254 KW - adolescent development latent class analysis relationship quality social capital KW - Convergence KW - Quality KW - Young adulthood KW - Interpersonal relationships KW - Adjustment KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919969931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Behavioral+Development&rft.atitle=Convergence+and+nonconvergence+in+the+quality+of+adolescent+relationships+and+its+association+with+adolescent+adjustment+and+young-adult+relationship+quality&rft.au=Jager%2C+Justin&rft.aulast=Jager&rft.aufirst=Justin&rft.date=2011-01-01&rft.volume=35&rft.issue=6&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Behavioral+Development&rft.issn=01650254&rft_id=info:doi/10.1177%2F0165025411422992 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-02-01 N1 - Number of references - 42 N1 - Last updated - 2016-09-27 N1 - CODEN - IJBDDY N1 - SubjectsTermNotLitGenreText - Adolescents; Interpersonal relationships; Quality; Convergence; Adjustment; Young adulthood DO - http://dx.doi.org/10.1177/0165025411422992 ER - TY - JOUR T1 - Establishment of the Genetic/Genomic Competency Center for Education AN - 919969409; 201201330 AB - Purpose: Develop a trans-disciplinary repository of genomics education resources using a Web-based learning management system. The repository maps and organizes genetic-genomic information and materials relevant to educators by healthcare discipline-specific competencies and performance indicators. Methods: An interdisciplinary project team was established to guide toolkit repository building and usability testing. The toolkit was built using the X-CREDIT software on the Moodle learning management platform, which includes a mapping matrix and browsing function that captures teaching resources in a searchable database linked to competencies, knowledge areas, performance indicators, learning activities and resources, and outcome assessments. Discipline-specific advisory groups assisted in resource identification, competency mapping, and peer review. The toolkit is multidisciplinary, currently including physician assistants and nurses, and provides a resource crosslink to discipline-specific competencies. All resources have a detailed description, and users may contribute new resources, which are peer reviewed for relevance and accuracy by an editorial board. Alpha and beta testing using online usability surveys that included toolkit exercises helped refine the structure, look, and navigation of the final website. Findings: One hundred thirty faculty-124 nursing and 6 physician assistant faculty-agreed to participate. Of those, 59 users (45.4% response rate) completed the online usability survey. Nearly all users (94.9%) were able to find a competency that was relevant to their topic, and 85.4% were able to locate the relevant performance indicators. The majority (86.5%) felt the model adequately described the relationships between competencies, performance indicators, learning activities-resources, and assessments, and made conceptual sense. Survey respondents reported font color and size made the information difficult to read, windows were not large enough, and the "shopping cart" concept was confusing; all of these areas have been modified for the final toolkit version. Conclusions: Alpha and beta testing of the toolkit revealed that users can successfully obtain educational materials by searching competencies and performance indicators. The platform is accessible on the Internet at and can be continually updated as new resources become available. Clinical Relevance: Faculty members need easy access to a wide range of accurate, current resources to facilitate integration of genomics into the curriculum. Adapted from the source document. JF - Journal of Nursing Scholarship AU - Calzone, Kathleen A AU - Jerome-D'Emilia, Bonnie AU - Jenkins, Jean AU - Goldgar, Constance AU - Rackover, Michael AU - Jackson, John AU - Chen, Ye AU - Voss, John AU - Feero, W Gregory AD - Xi, Senior Nurse Specialist, Research, National Institutes of Health, National Cancer Institute, Center for Cancer Research, Genetics Branch, Bethesda, MD Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 351 EP - 358 PB - Wiley-Blackwell, UK VL - 43 IS - 4 SN - 1527-6546, 1527-6546 KW - Interdisciplinary team work KW - Doctors' assistants KW - Learning KW - Mapping KW - Internet KW - Performance indicators KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919969409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nursing+Scholarship&rft.atitle=Establishment+of+the+Genetic%2FGenomic+Competency+Center+for+Education&rft.au=Calzone%2C+Kathleen+A%3BJerome-D%27Emilia%2C+Bonnie%3BJenkins%2C+Jean%3BGoldgar%2C+Constance%3BRackover%2C+Michael%3BJackson%2C+John%3BChen%2C+Ye%3BVoss%2C+John%3BFeero%2C+W+Gregory&rft.aulast=Calzone&rft.aufirst=Kathleen&rft.date=2011-01-01&rft.volume=43&rft.issue=4&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nursing+Scholarship&rft.issn=15276546&rft_id=info:doi/10.1111%2Fj.1547-5069.2011.01412.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-02-01 N1 - Number of references - 3 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Performance indicators; Internet; Learning; Interdisciplinary team work; Doctors' assistants; Mapping DO - http://dx.doi.org/10.1111/j.1547-5069.2011.01412.x ER - TY - JOUR T1 - REV1 Genetic Polymorphisms and Breast Cancer Risk in Thai Women AN - 918069309; 16155979 AB - Genomic DNA is exposed to a constant insult from sources that are both endogenous and exogenous to the cell. REV1 protein, a eukaryotic member of Y family of DNA polymerases, is involved in the tolerance to such DNA damages by providing a translesion DNA synthesis. Here, we examined possible association between REV1 polymorphisms and breast cancer risk in Thai women. Five single nucleotide polymorphisms (SNPs) REV1 (rs3792152, rs3087395, rs3792137, rs959929, rs3087386) were genotyped. The study population consists of 570 patients with histopathologically confirmed breast cancer and 497 controls. Association of genotypes with breast cancer risk was evaluated using multivariate logistic regression to estimate odds ratios (OR) and their 95% confidence intervals (95%CI). Our results revealed that the heterozygote carrier of REV1 SNP (rs3087395) was associated with breast cancer risk with OR=1.59 (95%CI: 1.11-2.29). In addition, an increased risk was observed for homozygotes at the REV1 SNP (rs 959929) with the OR=1.52 (95%CI: 1.01-2.29). A stratified analysis suggested that the association between the REV1 SNPs and breast cancer is different by the menopausal status. The present results suggest that REV1 polymorphisms are likely to play a modifying role in the individual susceptibility to breast cancer among Thai women. JF - Genes and Environment AU - Sangrajrang, Suleeporn AU - Sato, Yasunori AU - Sakamoto, Hiromi AU - Ohnami, Sumiko AU - Khuhaprema, Thiravud AU - Yoshida, Teruhiko AD - Research Division, National Cancer Institute Y1 - 2011 PY - 2011 DA - 2011 SP - 167 EP - 172 PB - The Japanese Environmental Mutagen Society VL - 33 IS - 4 SN - 1880-7062, 1880-7062 KW - Risk Abstracts; Health & Safety Science Abstracts; Sustainability Science Abstracts; Genetics Abstracts KW - Breast cancer KW - Cancer KW - DNA KW - DNA biosynthesis KW - DNA damage KW - DNA-directed DNA polymerase KW - Females KW - Gene polymorphism KW - Genotypes KW - Heterozygotes KW - Homozygotes KW - Population studies KW - Proteins KW - Single-nucleotide polymorphism KW - genomics KW - H 11000:Diseases/Injuries/Trauma KW - M3 1010:Issues in Sustainable Development KW - R2 23060:Medical and environmental health KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918069309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Heredity&rft.atitle=A+Linkage+Map+of+the+Asian+Tiger+Mosquito+%28Aedes+albopictus%29+Based+on+cDNA+Markers&rft.au=Sutherland%2C+Ian+W%3BMori%2C+Akio%3BMontgomery%2C+John%3BFleming%2C+Karen+L%3BAnderson%2C+Jennifer+M%3BValenzuela%2C+Jesus+G%3BSeverson%2C+David+W%3BBlack%2C+William+C%2C+IV&rft.aulast=Sutherland&rft.aufirst=Ian&rft.date=2011-01-01&rft.volume=102&rft.issue=1&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Journal+of+Heredity&rft.issn=00221503&rft_id=info:doi/10.1093%2Fjhered%2Fesq105 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - DNA biosynthesis; DNA damage; Single-nucleotide polymorphism; DNA-directed DNA polymerase; Gene polymorphism; Heterozygotes; Population studies; Breast cancer; genomics; Homozygotes; DNA; Proteins; Genotypes; Females; Cancer DO - http://dx.doi.org/10.3123/jemsge.33.167 ER - TY - JOUR T1 - Antagonistic Role of Tea Against Sodium Arsenite-Induced Oxidative DNA Damage and Inhibition of DNA Repair in Swiss Albino Mice AN - 918065965; 16155637 AB - Arsenic (As) contamination in groundwater is of increasing health concern in West Bengal, India. Arsenic has been associated with various human cancers, but the precise mechanism of its co-carcinogenic action is not clearly elucidated. Oxidative stress and defective repair mechanisms may promote accumulation of mutations and may be a stepping stone for carcinogenesis. Prevention of arsenic-induced oxidative stress and repair inhibition may reduce the chances of initiation of cancer. Tea polyphenols are reported to have excellent chemopreventive properties against cancer. This study aimed to elucidate the role of tea against arsenic-induced formation of 8-hydroxy-2?-deoxyguanosine (8OHdG) and arsenic-suppressed DNA repair in Swiss albino mice. Both green and black tea gave fruitful results in the reduction of 8OHdG and 8-oxoguanine DNA glycosylase (OGG1) in Swiss albino mice administered sodium arsenite (As III). DNA repair enzymes-such as PARP1, DNA [beta]-polymerase, XRCC1, DNA ligase III, DNA protein kinase (catalytic subunit), XRCC 4, DNA ligase IV, and DNA topoisomerase II[beta]-were induced by the phytochemicals at both the protein and genetic levels. Thus, tea polyphenols may prove effective in treating arsenic-induced carcinogenesis. JF - Journal of Environmental Pathology, Toxicology and Oncology AU - Sinha, Dona AU - Roy, Madhumita AD - Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, Kolkata, India Y1 - 2011 PY - 2011 DA - 2011 SP - 311 EP - 322 PB - Begell House Inc., 79 Madison Avenue, Suite 1201 New York NY 10016-7892 United States VL - 30 IS - 4 SN - 0731-8898, 0731-8898 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Protein kinase C KW - Arsenic KW - Sodium arsenite KW - Polyphenols KW - poly(ADP-ribose) polymerase 1 KW - Contamination KW - DNA glycosylase KW - DNA topoisomerase KW - XRCC1 protein KW - DNA repair KW - Cancer KW - DNA damage KW - Oxidative stress KW - Tea KW - Carcinogenesis KW - Ground water KW - DNA ligase (ATP) KW - OGG1 protein KW - Mutation KW - N 14820:DNA Metabolism & Structure KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918065965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.atitle=Antagonistic+Role+of+Tea+Against+Sodium+Arsenite-Induced+Oxidative+DNA+Damage+and+Inhibition+of+DNA+Repair+in+Swiss+Albino+Mice&rft.au=Sinha%2C+Dona%3BRoy%2C+Madhumita&rft.aulast=Sinha&rft.aufirst=Dona&rft.date=2011-01-01&rft.volume=30&rft.issue=4&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Protein kinase C; Arsenic; Sodium arsenite; Contamination; poly(ADP-ribose) polymerase 1; Polyphenols; DNA glycosylase; DNA topoisomerase; XRCC1 protein; DNA repair; Cancer; DNA damage; Tea; Oxidative stress; Carcinogenesis; Ground water; OGG1 protein; DNA ligase (ATP); Mutation ER - TY - JOUR T1 - Life on the Outside: The Rescue of Coxiella burnetii from Its Host Cell AN - 918049382; 16074560 AB - For over seven decades, Coxiella burnetii, the causative agent of human Q fever, has been considered a prototypical obligate intracellular bacterium that relies exclusively on a eukaryotic cell for growth. Intracellularly, the organism prospers in an acidified, phagolysosome-like vacuole. C. burnetii has evolved to replicate in this harsh compartment by a mechanism involving acid activation of metabolism. The similar to 2 Mb genome of C. burnetii is about twice the size of genomes of most obligate intracellular bacteria, and the organism's central metabolic pathways are largely intact. The absence of extensive genome reduction suggests the adaptation of C. burnetii to an obligate intracellular lifestyle is a recent evolutionary event. Indeed, insight from early work on C. burnetii metabolism, along with new information gained from metabolic pathway reconstructions, nutrient typing, and expression profiling, allowed the rescue of C. burnetii from its host cell to regain the axenic growth capacity of its ancestors. This advance removes the extensive experimental obstacles associated with intracellular obligatism and opens the door for a renaissance in C. burnetii research. JF - Annual Review of Microbiology AU - Omsland, A AU - Heinzen, R A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA, rheinzen@niaid.nih.gov Y1 - 2011 PY - 2011 DA - 2011 SP - 111 EP - 128 VL - 65 SN - 0066-4227, 0066-4227 KW - Microbiology Abstracts B: Bacteriology KW - Genomes KW - Coxiella burnetii KW - Typing KW - Adaptations KW - Reviews KW - Vacuoles KW - Metabolic pathways KW - Nutrients KW - Q fever KW - Evolution KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918049382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Microbiology&rft.atitle=Life+on+the+Outside%3A+The+Rescue+of+Coxiella+burnetii+from+Its+Host+Cell&rft.au=Omsland%2C+A%3BHeinzen%2C+R+A&rft.aulast=Omsland&rft.aufirst=A&rft.date=2011-01-01&rft.volume=65&rft.issue=&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Microbiology&rft.issn=00664227&rft_id=info:doi/10.1146%2Fannurev-micro-090110-102927 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Genomes; Adaptations; Typing; Reviews; Vacuoles; Metabolic pathways; Nutrients; Q fever; Evolution; Coxiella burnetii DO - http://dx.doi.org/10.1146/annurev-micro-090110-102927 ER - TY - JOUR T1 - The RpoS-Mediated General Stress Response In Escherichia coli AN - 918049373; 16074556 AB - Under conditions of nutrient deprivation or stress, or as cells enter stationary phase, Escherichia coli and related bacteria increase the accumulation of RpoS, a specialized sigma factor. RpoS-dependent gene expression leads to general stress resistance of cells. During rapid growth, RpoS translation is inhibited and any RpoS protein that is synthesized is rapidly degraded. The complex transition from exponential growth to stationary phase has been partially dissected by analyzing the induction of RpoS after specific stress treatments. Different stress conditions lead to induction of specific sRNAs that stimulate RpoS translation or to induction of small-protein antiadaptors that stabilize the protein. Recent progress has led to a better, but still far from complete, understanding of how stresses lead to RpoS induction and what RpoS-dependent genes help the cell deal with the stress. JF - Annual Review of Microbiology AU - Battesti, A AU - Majdalani, N AU - Gottesman, S AD - Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA, battestia@mail.nih.gov Y1 - 2011 PY - 2011 DA - 2011 SP - 189 EP - 213 VL - 65 SN - 0066-4227, 0066-4227 KW - Microbiology Abstracts B: Bacteriology KW - stationary phase KW - Gene expression KW - Translation KW - Reviews KW - Escherichia coli KW - Stress KW - Nutrients KW - Sigma factor KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918049373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Microbiology&rft.atitle=The+RpoS-Mediated+General+Stress+Response+In+Escherichia+coli&rft.au=Battesti%2C+A%3BMajdalani%2C+N%3BGottesman%2C+S&rft.aulast=Battesti&rft.aufirst=A&rft.date=2011-01-01&rft.volume=65&rft.issue=&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Microbiology&rft.issn=00664227&rft_id=info:doi/10.1146%2Fannurev-micro-090110-102946 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Gene expression; stationary phase; Translation; Reviews; Stress; Nutrients; Sigma factor; Escherichia coli DO - http://dx.doi.org/10.1146/annurev-micro-090110-102946 ER - TY - JOUR T1 - Will biomedical enhancements undermine solidarity, responsibility, equality and autonomy AN - 917299177; 4262214 AB - Prominent thinkers such as Jurgen Habermas and Michael Sandel are warning that biomedical enhancements will undermine fundamental political values. Yet whether biomedical enhancements will undermine such values depends on how biomedical enhancements will function, how they will be administered and to whom. Since only few enhancements are obtainable, it is difficult to tell whether these predictions are sound. Nevertheless, such warnings are extremely valuable. As a society we must, at the very least, be aware of developments that could have harmful consequences. Indeed, if important values were to be jeopardized, we should take appropriate measures to protect them. This paper focuses on four central values: solidarity, personal responsibility, equality and autonomy. It delineates the conditions under which biomedical enhancements would undermine these values. It also details the circumstances under which these values would be unaffected by enhancements as well as those under which they would be promoted. Specifying these conditions is valuable; it would enable society to prepare appropriate ethical guidelines and policy responses in advance. Adapted from the source document. Reprinted by permission of Blackwell Publishers JF - Bioethics AU - Lev, Ori AD - National Human Genome Research Institute Y1 - 2011 PY - 2011 DA - 2011 SP - 177 EP - 184 VL - 25 IS - 4 SN - 0269-9702, 0269-9702 KW - Sociology KW - Anthropology KW - Values KW - Responsibility KW - Solidarity KW - Biomedicine KW - Autonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/917299177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Carbohydrates+contribute+to+the+interactions+between+cockroach+allergen+Bla+g+2+and+a+monoclonal+antibody.&rft.au=Li%2C+Mi%3BGustchina%2C+Alla%3BGlesner%2C+Jill%3BW%C3%BCnschmann%2C+Sabina%3BVailes%2C+Lisa+D%3BChapman%2C+Martin+D%3BPom%C3%A9s%2C+Anna%3BWlodawer%2C+Alexander&rft.aulast=Li&rft.aufirst=Mi&rft.date=2011-01-01&rft.volume=186&rft.issue=1&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/10.4049%2Fjimmunol.1002318 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1618 7894; 13245 8281 6085; 12065 11843; 1425 2119 2116 5551 7506 5586 9792; 10970 DO - http://dx.doi.org/10.1111/j.1467-8519.2009.01779.x ER - TY - JOUR T1 - Advancing sustainability research: challenging existing paradigms AN - 912922858; 15252132 AB - No abstract is available for this article. JF - Journal of Public Health Dentistry AU - Dphil, David A Chambers Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - S99 EP - S100 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 71 IS - Supplement s1 SN - 1752-7325, 1752-7325 KW - Sustainability Science Abstracts KW - dentistry KW - sustainability KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912922858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Public+Health+Dentistry&rft.atitle=Advancing+sustainability+research%3A+challenging+existing+paradigms&rft.au=Dphil%2C+David+A+Chambers&rft.aulast=Dphil&rft.aufirst=David+A&rft.date=2011-01-01&rft.volume=71&rft.issue=Supplement+s1&rft.spage=S99&rft.isbn=&rft.btitle=&rft.title=Journal+of+Public+Health+Dentistry&rft.issn=17527325&rft_id=info:doi/10.1111%2Fj.1752-7325.2011.00238.x L2 - http://onlinelibrary.wiley.com/doi/10.1111/j.1752-7325.2011.00238.x/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - dentistry; sustainability DO - http://dx.doi.org/10.1111/j.1752-7325.2011.00238.x ER - TY - JOUR T1 - Variation and evolution of the ABC transporter genes ABCB1, ABCC1, ABCG2, ABCG5 and ABCG8: implication for pharmacogenetics and disease. AN - 911931824; 22098604 AB - The ATP-binding cassette (ABC) transporter genes are ubiquitous in the genomes of all vertebrates. Some of these transporters play a key role in xenobiotic defense and are endowed with the capacity to efflux harmful toxic substances. A major role in the evolution of the vertebrate ABC genes is played by gene duplication. Multiple gene duplication and deletion events have been identified in ABC genes, resulting in either gene birth or gene death indicating that the process of gene evolution is still ongoing in this group of transporters. Additionally, polymorphisms in these genes are linked to variations in expression, function, drug disposition and drug response. Single nucleotide polymorphisms in the ABC genes may be considered as markers of individual risk for adverse drug reactions or susceptibility to complex diseases as they can uniquely influence the quality and quantity of gene product. As the ABC genes continue to evolve, globalization will yield additional migration and racial admixtures that will have far reaching implications for the pharmacogenetics of this unique family of transporters in the context of human health. JF - Drug metabolism and drug interactions AU - Silverton, Latoya AU - Dean, Michael AU - Moitra, Karobi AD - Laboratory of Experimental Immunology, Cancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA. Y1 - 2011 PY - 2011 DA - 2011 SP - 169 EP - 179 VL - 26 IS - 4 SN - 0792-5077, 0792-5077 KW - ABCB1 protein, human KW - 0 KW - ABCG2 protein, human KW - ABCG5 protein, human KW - ABCG8 protein, human KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 5 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 8 KW - Lipoproteins KW - Multidrug Resistance-Associated Proteins KW - Neoplasm Proteins KW - P-Glycoprotein KW - P-Glycoproteins KW - multidrug resistance-associated protein 1 KW - Y49M64GZ4Q KW - Index Medicus KW - Genetic Variation KW - Animals KW - Lipoproteins -- genetics KW - P-Glycoprotein -- genetics KW - Humans KW - Neoplasm Proteins -- genetics KW - Multidrug Resistance-Associated Proteins -- genetics KW - ATP-Binding Cassette Transporters -- genetics KW - Pharmacogenetics KW - Evolution, Molecular UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911931824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+drug+interactions&rft.atitle=Variation+and+evolution+of+the+ABC+transporter+genes+ABCB1%2C+ABCC1%2C+ABCG2%2C+ABCG5+and+ABCG8%3A+implication+for+pharmacogenetics+and+disease.&rft.au=Silverton%2C+Latoya%3BDean%2C+Michael%3BMoitra%2C+Karobi&rft.aulast=Silverton&rft.aufirst=Latoya&rft.date=2011-01-01&rft.volume=26&rft.issue=4&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+drug+interactions&rft.issn=07925077&rft_id=info:doi/10.1515%2FDMDI.2011.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-29 N1 - Date created - 2011-12-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1515/DMDI.2011.027 ER - TY - JOUR T1 - Occupational cancer monitoring: a unique opportunity to protect human health AN - 911165246; 15940380 AB - OBJECTIVES: Many human carcinogens were first discovered in the workplace. Even today the workers surveillance provides a unique opportunity to study and protect human health. However, a systematic exploration of cancer risk to evaluate whether workers are/were exposed to carcinogenic hazards is unusual in EU. METHODS AND RESULTS: In Italy such a system, based on available electronic archives, is active and has proven to be very effective to: (1) estimate the cancer risk by area, economic sector and cancer site; (2) identify new or unusual economic activities where carcinogenic hazards can be present; (3) produce new hypotheses of carcinogenic hazards; (4) identify cases of potential occupational origin. CONCLUSIONS: Based on our experience, and taking into account other EU experiences (eg, those of Nordic Countries), here we propose to set up a network of EU institutions and experts to assess the feasibility in each EU country of a systematic occupational cancer monitoring JF - Occupational and Environmental Medicine AU - Crosignani, Paolo AU - Bai, Edoardo AU - Oddone, Enrico AD - National Cancer Institute, Milan, Italy Y1 - 2011 PY - 2011 DA - 2011 SP - A112 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 68 SN - 1351-0711, 1351-0711 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Italy KW - Cancer KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911165246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Occupational+cancer+monitoring%3A+a+unique+opportunity+to+protect+human+health&rft.au=Crosignani%2C+Paolo%3BBai%2C+Edoardo%3BOddone%2C+Enrico&rft.aulast=Crosignani&rft.aufirst=Paolo&rft.date=2011-01-01&rft.volume=68&rft.issue=&rft.spage=A112&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Cancer; Italy ER - TY - JOUR T1 - Public health impact of exposure to occupational carcinogens on lung cancer risk AN - 911161365; 15940308 AB - OBJECTIVES: Exposure to occupational carcinogens is an important preventable cause of lung cancer. Most of the previous studies were in highly exposed industrial cohorts The authors' aim was to quantify lung cancer burden attributable to occupational carcinogens in a general population. METHODS: They applied a new job-exposure matrix (JEM) to translate lifetime work-histories into never, low, and high exposure levels for 6 known/suspected lung carcinogens in the Environment And Genetics in Lung cancer Etiology (EAGLE) case-control study, that enrolled 2100 lung cancer cases and 2120 population controls in Lombardy, Italy, in 2002-2005. ORs and 95% CIs were calculated in men (1537 cases and 1617 controls), by logistic regression adjusted for potential confounders, including smoking and co-exposure to JEM carcinogens. The population attributable fraction (PAF) was estimated as impact measure. RESULTS: Men showed an excess risk even at low exposure to asbestos (OR=1.76, 95% CI: 1.42 to 2.18), crystalline silica (OR=1.31, 95% CI: 1.00 to 1.71), and nickel-chromium (OR=1.18, 95% CI: 0.90 to 1.53), with positive trends for intensity. An increased risk only for high exposure to polycyclic aromatic hydrocarbons was found (OR=1.64, 95% CI: 0.99 to 2.70). The PAFs for any exposure to asbestos, silica and nickel-chromium were 18.1%, 5.7%, and 7.0%, respectively, corresponding to about 300-800 cases/year in Lombardy. CONCLUSIONS: These findings support the substantial role of occupational carcinogens on lung cancer burden, even in a low exposed general population. JF - Occupational and Environmental Medicine AU - De Matteis, Sara AU - Consonni, Dario AU - Lubin, Jay AU - Tucker, Margaret AU - Peters, Susan AU - Vermeulen, Roel AU - Kromhout, Hans AU - Bertazzi, Pier Alberto AU - Caporaso, Neil AU - Pesatori, Angela Cecilia AU - Wacholder, Sholom AU - Landi, Maria Teresa AD - NCI, Bethesda, USA Y1 - 2011 PY - 2011 DA - 2011 SP - A16 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 68 SN - 1351-0711, 1351-0711 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Asbestos KW - Italy KW - Lung cancer KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911161365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Public+health+impact+of+exposure+to+occupational+carcinogens+on+lung+cancer+risk&rft.au=De+Matteis%2C+Sara%3BConsonni%2C+Dario%3BLubin%2C+Jay%3BTucker%2C+Margaret%3BPeters%2C+Susan%3BVermeulen%2C+Roel%3BKromhout%2C+Hans%3BBertazzi%2C+Pier+Alberto%3BCaporaso%2C+Neil%3BPesatori%2C+Angela+Cecilia%3BWacholder%2C+Sholom%3BLandi%2C+Maria+Teresa&rft.aulast=De+Matteis&rft.aufirst=Sara&rft.date=2011-01-01&rft.volume=68&rft.issue=&rft.spage=A16&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Lung cancer; Italy ER - TY - JOUR T1 - A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates AN - 911161254; 15939788 AB - Blinding trachoma is an ancient neglected tropical disease caused by Chlamydia trachomatis for which a vaccine is needed. We describe a live-attenuated vaccine that is safe and efficacious in preventing trachoma in nonhuman primates, a model with excellent predictive value for humans. Cynomolgus macaques infected ocularly with a trachoma strain deficient for the 7.5-kb conserved plasmid presented with short-lived infections that resolved spontaneously without ocular pathology. Multiple infections with the attenuated plasmid-deficient strain produced no inflammatory ocular pathology but induced an anti-chlamydial immune response. Macaques vaccinated with the attenuated strain were either solidly or partially protected after challenge with virulent plasmid-bearing organisms. Partially protected macaques shed markedly less infectious organisms than controls. Immune correlates of protective immunity were not identified, but we did detect a correlation between MHC class II alleles and solid versus partial protection. Epidemiological models of trachoma control indicate that a vaccine with this degree of efficacy would significantly reduce the prevalence of infection and rates of reinfection, known risk factors which drive blinding disease. JF - Journal of Experimental Medicine AU - Kari, Laszlo AU - Whitmire, William M AU - Olivares-Zavaleta, Norma AU - Goheen, Morgan M AU - Taylor, Lacey D AU - Carlson, John H AU - Sturdevant, Gail L AU - Lu, Chunxue AU - Bakios, Lauren E AU - Randall, Linnell B AU - Parnell, Michael J AU - Zhong, Guangming AU - Caldwell, Harlan D AD - Laboratory of Intracellular Parasites and Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840 Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 2217 EP - 2223 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 United States VL - 208 IS - 11 SN - 0022-1007, 0022-1007 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Prediction KW - Pathology KW - Allelles KW - Macaca KW - Animal models KW - Disease control KW - Chlamydia trachomatis KW - Major histocompatibility complex KW - Immunity KW - Infection KW - Defence mechanisms KW - Plasmids KW - Vaccination KW - Trachoma KW - Inflammation KW - Risk factors KW - Cynomolgus KW - Immune response KW - Vaccines KW - F 06905:Vaccines KW - Q1 08484:Species interactions: parasites and diseases KW - J 02350:Immunology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911161254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=A+live-attenuated+chlamydial+vaccine+protects+against+trachoma+in+nonhuman+primates&rft.au=Kari%2C+Laszlo%3BWhitmire%2C+William+M%3BOlivares-Zavaleta%2C+Norma%3BGoheen%2C+Morgan+M%3BTaylor%2C+Lacey+D%3BCarlson%2C+John+H%3BSturdevant%2C+Gail+L%3BLu%2C+Chunxue%3BBakios%2C+Lauren+E%3BRandall%2C+Linnell+B%3BParnell%2C+Michael+J%3BZhong%2C+Guangming%3BCaldwell%2C+Harlan+D&rft.aulast=Kari&rft.aufirst=Laszlo&rft.date=2011-01-01&rft.volume=208&rft.issue=11&rft.spage=2217&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Prediction; Pathology; Allelles; Disease control; Immunity; Vaccines; Plasmids; Defence mechanisms; Risk factors; Animal models; Major histocompatibility complex; Immune response; Infection; Vaccination; Inflammation; Trachoma; Macaca; Chlamydia trachomatis; Cynomolgus ER - TY - JOUR T1 - Combining job exposure matrices and exposure measurements to assess occupational exposure to benzene, lead fume, and lead dust in a population-based cohort in Shanghai, China AN - 911161236; 15940274 AB - OBJECTIVES: To better discriminate between job, industry, and time differences in exposure levels within a population cohort of 74 942 Shanghai women, we combined job exposure matrix (JEM) ratings with inspection measurements collected between 1954 and 2000. METHODS: Mixed-effects models were used to predict concentrations of benzene (n=63 221 measurements), lead fume (n=20 084), and lead dust (n=5383). The fixed effects included JEM intensity ratings (ordinal: 0-3) and year (b-spline). The random effects included job and industry nested within job, which allowed us to calculate job/industry-specific estimates when there was sufficient data. The predicted concentrations were applied to the cohort when either the job or industry JEM probability rating was high (3 on a 0-3 scale). RESULTS: The average exposure levels were 9-12 times higher in 1965 than in 2000 for the three agents. The ranges of the job/industry group exposure concentrations were 2-7 times wider for the job/industry-specific estimates than for the JEM-specific estimates. Using the probability ratings, we estimated that 15% and 8% of the subjects were exposed to benzene and lead, respectively. CONCLUSIONS: Our approach calibrated the JEM to a concentration scale across ratings and time and allowed the job/industry groups' exposure levels to deviate from the JEM estimate when there were sufficient measurements. It also provided a mechanism to estimate exposure when a job/industry group was not represented in the exposure database. As a result, our approach accounted for substantial exposure differences across time and between jobs and industries that would not be accounted for using the JEM alone. JF - Occupational and Environmental Medicine AU - Friesen, Melissa AU - Koh, Dong-Hee AU - Coble, Joseph AU - Lu, Wei AU - Shu, Xiao-Ou AU - Ji, Bu-Tian AU - Xue, Shouzheng AU - Portengen, Lutzen AU - Chow, Wong-Ho AU - Gao, Yu-Tang AU - Yang, Gong AU - Rothman, Nathaniel AU - Vermeulen, Roel AD - NCI, Bethesda, USA Y1 - 2011 PY - 2011 DA - 2011 SP - A26 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 68 SN - 1351-0711, 1351-0711 KW - Health & Safety Science Abstracts KW - Fumes KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - inspection KW - Lead KW - Benzene KW - Dust KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911161236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Combining+job+exposure+matrices+and+exposure+measurements+to+assess+occupational+exposure+to+benzene%2C+lead+fume%2C+and+lead+dust+in+a+population-based+cohort+in+Shanghai%2C+China&rft.au=Friesen%2C+Melissa%3BKoh%2C+Dong-Hee%3BCoble%2C+Joseph%3BLu%2C+Wei%3BShu%2C+Xiao-Ou%3BJi%2C+Bu-Tian%3BXue%2C+Shouzheng%3BPortengen%2C+Lutzen%3BChow%2C+Wong-Ho%3BGao%2C+Yu-Tang%3BYang%2C+Gong%3BRothman%2C+Nathaniel%3BVermeulen%2C+Roel&rft.aulast=Friesen&rft.aufirst=Melissa&rft.date=2011-01-01&rft.volume=68&rft.issue=&rft.spage=A26&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Fumes; inspection; Occupational exposure; Dust; Benzene; Lead; China, People's Rep., Shanghai; China, People's Rep. ER - TY - JOUR T1 - Daily measures of microbes and human health at a non-point source marine beach AN - 911160197; 16066857 AB - Studies evaluating the relationship between microbes and human health at non-point source beaches are necessary for establishing criteria which would protect public health while minimizing economic burdens. The objective of this study was to evaluate water quality and daily cumulative health effects (gastrointestinal, skin, and respiratory illnesses) for bathers at a non-point source subtropical marine recreational beach in order to better understand the inter-relationships between these factors and hence improve monitoring and pollution prevention techniques. Daily composite samples were collected, during the Oceans and Human Health Beach Exposure Assessment and Characterization Health Epidemiologic Study conducted in Miami (Florida, USA) at a non-point source beach, and analyzed for several pathogens, microbial source tracking markers, indicator microbes, and environmental parameters. Analysis demonstrated that rainfall and tide were more influential, when compared to other environmental factors and source tracking markers, in determining the presence of both indicator microbes and pathogens. Antecedent rainfall and F+ coliphage detection in water should be further assessed to confirm their possible association with skin and gastrointestinal (GI) illness outcomes, respectively. The results of this research illustrate the potential complexity of beach systems characterized by non-point sources, and how more novel and comprehensive approaches are needed to assess beach water quality for the purpose of protecting bather health. JF - Journal of Water and Health AU - Abdelzaher, Amir M AU - Wright, Mary E AU - Ortega, Cristina AU - Hasan, A Rasem AU - Shibata, Tomoyoki AU - Solo-Gabriele, Helena M AU - Kish, Jonathan AU - Withum, Kelly AU - He, Guoqing AU - Elmir, Samir M AU - Bonilla, J Alfredo AU - Bonilla, Tonya D AU - Palmer, Carol J AU - Scott, Troy M AU - Lukasik, Jerzy AU - Harwood, Valerie J AU - McQuaig, Shannon AU - Sinigalliano, Christopher D AU - Gidley, Maribeth L AU - Wanless, David AU - Plano, Lisa R W AU - Garza, Anna C AU - Zhu, Xiaofang AU - Stewart, Jill R AU - Dickerson, Jerold W AU - Yampara-Iquise, Helen AU - Carson, Charles AU - Fleisher, Jay M AU - Fleming, Lora E AD - NSF NIEHS Oceans and Human Health Center, University of Miami, 4600 Rickenbacker Causeway Miami, FL 33149, USA, hmsolo@miami.edu Y1 - 2011 PY - 2011 DA - 2011 SP - 443 EP - 457 PB - IWA Publishing, Alliance House London SW1H 0QS United Kingdom VL - 9 IS - 3 SN - 1477-8920, 1477-8920 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA Marine Biotechnology Abstracts; Pollution Abstracts; Environment Abstracts; Water Resources Abstracts; Aqualine Abstracts KW - water quality KW - Rainfall KW - Indicators KW - Water quality KW - Public health KW - Economics KW - ASW, USA, Florida KW - Water Quality KW - Nonpoint pollution KW - Shore protection KW - Monitoring KW - Pollution monitoring KW - Pollution effects KW - Environmental factors KW - Assessments KW - Beaches KW - Skin KW - Nonpoint Pollution Sources KW - ASW, USA, Florida, Miami KW - Pathogens KW - Tides KW - Water pollution KW - Tracking KW - Oceans KW - AQ 00001:Water Resources and Supplies KW - SW 3040:Wastewater treatment processes KW - Q4 27760:Microorganisms KW - P 1000:MARINE POLLUTION KW - ENA 12:Oceans & Estuaries KW - Q5 08522:Protective measures and control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911160197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Water+and+Health&rft.atitle=Daily+measures+of+microbes+and+human+health+at+a+non-point+source+marine+beach&rft.au=Abdelzaher%2C+Amir+M%3BWright%2C+Mary+E%3BOrtega%2C+Cristina%3BHasan%2C+A+Rasem%3BShibata%2C+Tomoyoki%3BSolo-Gabriele%2C+Helena+M%3BKish%2C+Jonathan%3BWithum%2C+Kelly%3BHe%2C+Guoqing%3BElmir%2C+Samir+M%3BBonilla%2C+J+Alfredo%3BBonilla%2C+Tonya+D%3BPalmer%2C+Carol+J%3BScott%2C+Troy+M%3BLukasik%2C+Jerzy%3BHarwood%2C+Valerie+J%3BMcQuaig%2C+Shannon%3BSinigalliano%2C+Christopher+D%3BGidley%2C+Maribeth+L%3BWanless%2C+David%3BPlano%2C+Lisa+R+W%3BGarza%2C+Anna+C%3BZhu%2C+Xiaofang%3BStewart%2C+Jill+R%3BDickerson%2C+Jerold+W%3BYampara-Iquise%2C+Helen%3BCarson%2C+Charles%3BFleisher%2C+Jay+M%3BFleming%2C+Lora+E&rft.aulast=Abdelzaher&rft.aufirst=Amir&rft.date=2011-01-01&rft.volume=9&rft.issue=3&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Journal+of+Water+and+Health&rft.issn=14778920&rft_id=info:doi/10.2166%2Fwh.2011.146 L2 - http://www.iwaponline.com/jwh/009/jwh0090443.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Pollution monitoring; Shore protection; Pollution effects; Pathogens; Water quality; Environmental factors; Tracking; Water pollution; Public health; Beaches; Skin; Oceans; Rainfall; Economics; Tides; water quality; Nonpoint pollution; Assessments; Indicators; Water Quality; Nonpoint Pollution Sources; Monitoring; ASW, USA, Florida; ASW, USA, Florida, Miami DO - http://dx.doi.org/10.2166/wh.2011.146 ER - TY - JOUR T1 - Atrazine and cancer incidence among pesticide applicators in the Agricultural Health Study (1994-2007) AN - 911153904; 15940312 AB - OBJECTIVES: Atrazine is a triazine herbicide with endocrine-disrupting properties and is used widely in the United States. Atrazine causes mammary tumours in rats, but the mechanism does not appear to operate in humans. Few epidemiologic studies have provided evidence for an association. Here, we extend a previous analysis of cancer risk associated with self-reported atrazine use in the Agricultural Health Study, a prospective cohort that includes 57 310 licensed pesticide applicators, with six additional years of follow-up and over twice as many cancer cases (n=3146). METHODS: Using Poisson regression, we calculated RR estimates and 95% CI for lifetime days of use of atrazine and intensity-weighted lifetime days, which accounts for factors that impact exposure. RESULTS: Overall, 68% of applicators reported using atrazine. There was no increased risk among atrazine users for cancer overall or at most sites. Based on 29 exposed cases of thyroid cancer, there was a significant risk in the highest category of intensity-weighted lifetime days (RR=4.86; 95% CI: 1.31 to 17.99, p-trend=0.01). There was a similar pattern for lifetime days (RR=2.31; 95% CI: 0.65 to 8.19, p-trend=0.27), but neither the risk estimates nor the trend were statistically significant, and for neither metric was the trend monotonic. For ovarian cancer, there was a suggestion of increased risk among female applicators who ever used atrazine, but numbers were small (n=4). CONCLUSIONS: There was a suggestion of increased risk of cancers of the thyroid and ovaries, sites of a priori interest due to their hormonal involvement, but with minimal supporting evidence. JF - Occupational and Environmental Medicine AU - Freeman, Laura Beane AU - Rusiecki, Jennifer AU - Hoppin, Jane AU - Lubin, Jay AU - Koutros, Stella AU - Andreotti, Gabriella AU - Zahm, Shelia Hoar AU - Hines, Cynthia AU - Coble, Joseph AU - Barone-Adesi, Francesco AU - Sloan, Jennifer AU - Sandler, Dale AU - Blair, Aaron AU - Alavanja, Michael AD - NCI, Rockville, USA Y1 - 2011 PY - 2011 DA - 2011 SP - A15 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 68 SN - 1351-0711, 1351-0711 KW - Health & Safety Science Abstracts KW - Atrazine KW - USA KW - Cancer KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911153904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Atrazine+and+cancer+incidence+among+pesticide+applicators+in+the+Agricultural+Health+Study+%281994-2007%29&rft.au=Freeman%2C+Laura+Beane%3BRusiecki%2C+Jennifer%3BHoppin%2C+Jane%3BLubin%2C+Jay%3BKoutros%2C+Stella%3BAndreotti%2C+Gabriella%3BZahm%2C+Shelia+Hoar%3BHines%2C+Cynthia%3BCoble%2C+Joseph%3BBarone-Adesi%2C+Francesco%3BSloan%2C+Jennifer%3BSandler%2C+Dale%3BBlair%2C+Aaron%3BAlavanja%2C+Michael&rft.aulast=Freeman&rft.aufirst=Laura&rft.date=2011-01-01&rft.volume=68&rft.issue=&rft.spage=A15&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Cancer; USA ER - TY - JOUR T1 - Sedentary Activity Associated With Metabolic Syndrome Independent of Physical Activity AN - 911152335; 14299966 AB - OBJECTIVE: This study examined the association between objectively measured sedentary activity and metabolic syndrome among older adults. RESEARCH DESIGN AND METHODS: Data were from 1,367 men and women, aged greater than or equal to 60 years who participated in the 2003-2006 National Health and Nutrition Examination Survey (NHANES). Sedentary time during waking hours was measured by an accelerometer (5 min. A sedentary break was defined as an interruption in sedentary time ( greater than or equal to 100 counts per minute). Metabolic syndrome was defined according to the Adult Treatment Panel (ATP) III criteria. RESULTS: On average, people spent 9.5 h (65% of wear time) as sedentary. Compared with people without metabolic syndrome, people with metabolic syndrome spent a greater percentage of time as sedentary (67.3 vs. 62.2%), had longer average sedentary bouts (17.7 vs. 16.7 min), had lower intensity during sedentary time (14.8 vs. 15.8 average counts per minute), and had fewer sedentary breaks (82.3 vs. 86.7), adjusted for age and sex (all P CONCLUSIONS: The proportion of sedentary time was strongly related to metabolic risk, independent of physical activity. Current results suggest older people may benefit from reducing total sedentary time and avoiding prolonged periods of sedentary time by increasing the number of breaks during sedentary time. JF - Diabetes Care AU - Bankoski, Andrea AU - Harris, Tamara B AU - McClain, James J AU - Brychta, Robert J AU - Caserotti, Paolo AU - Chen, Kong Y AU - Berrigan, David AU - Troiano, Richard P AU - Koster, Annemarie AD - Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 497 EP - 503 PB - American Diabetes Association, 1701 N. Beauregard St. Alexandria VA 22311 USA VL - 34 IS - 2 SN - 0149-5992, 0149-5992 KW - Physical Education Index KW - Sex education KW - Measurement KW - Alcohol KW - Gerontology KW - Exercise KW - Adults KW - Nutrition KW - Diabetes KW - Heart diseases KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911152335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+Care&rft.atitle=Sedentary+Activity+Associated+With+Metabolic+Syndrome+Independent+of+Physical+Activity&rft.au=Bankoski%2C+Andrea%3BHarris%2C+Tamara+B%3BMcClain%2C+James+J%3BBrychta%2C+Robert+J%3BCaserotti%2C+Paolo%3BChen%2C+Kong+Y%3BBerrigan%2C+David%3BTroiano%2C+Richard+P%3BKoster%2C+Annemarie&rft.aulast=Bankoski&rft.aufirst=Andrea&rft.date=2011-01-01&rft.volume=34&rft.issue=2&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=Diabetes+Care&rft.issn=01495992&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Alcohol; Measurement; Sex education; Gerontology; Adults; Exercise; Nutrition; Heart diseases; Diabetes ER - TY - JOUR T1 - Obesity, diabetes and hypertension associated with antipsychotic use in remitted schizophrenia AN - 911152049; 15946404 AB - Objective: To ascertain the prevalence of diabetes, obesity and hypertension associated with antipsychotic use in remitted patients with schizophrenia. Methods: This study included a cross sectional survey of diabetes, obesity and hypertension among all remitted patients diagnosed with schizophrenia/schizoaffective disorder (n = 130) on at least 6 months of antipsychotic treatment. Results: A prevalence of 35.4% obesity, 1.5% hypertension and 3.8% (ADA) or 5.4% (WHO) prevalence of diabetes was observed. Conclusions: The use of antipsychotic drugs in the long run may be associated with a significantly greater risk of developing obesity with moderate influence on development of diabetes and minimal to none on hypertension. JF - International Journal of Risk and Safety in Medicine AU - Saddichha, Sahoo AU - Vishnuvardhan, Gopalkrishnan AU - Akhtar, Sayeed AD - Senior Resident in Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 181 EP - 185 PB - IOS Press, Nieuwe Hemweg 6B Amsterdam 1013 BG Netherlands VL - 23 IS - 3 SN - 0924-6479, 0924-6479 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Diabetes KW - obesity KW - hypertension KW - schizophrenia KW - antipsychotic treatment KW - diabetes mellitus KW - Neuroleptics KW - mental disorders KW - Drugs KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911152049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Risk+and+Safety+in+Medicine&rft.atitle=Obesity%2C+diabetes+and+hypertension+associated+with+antipsychotic+use+in+remitted+schizophrenia&rft.au=Saddichha%2C+Sahoo%3BVishnuvardhan%2C+Gopalkrishnan%3BAkhtar%2C+Sayeed&rft.aulast=Saddichha&rft.aufirst=Sahoo&rft.date=2011-01-01&rft.volume=23&rft.issue=3&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Risk+and+Safety+in+Medicine&rft.issn=09246479&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - diabetes mellitus; Neuroleptics; hypertension; obesity; Drugs; mental disorders ER - TY - JOUR T1 - Selecting Weight Loss Surgery Based on HDL Genotype-Are We There Yet? At the Brink of "Personalized Surgery" AN - 911149680; 14894393 JF - Journal of Clinical Endocrinology and Metabolism AU - Rother, Kristina I AU - Brown, Rebecca J AD - Diabetes, Obesity, and Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2011 PY - 2011 DA - 2011 SP - 1664 EP - 1667 PB - Endocrine Society, 4350 East West Highway Bethesda MD 20814-4426 USA VL - 96 IS - 6 SN - 0021-972X, 0021-972X KW - Physical Education Index KW - Weight control KW - Surgery KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911149680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.atitle=Selecting+Weight+Loss+Surgery+Based+on+HDL+Genotype-Are+We+There+Yet%3F+At+the+Brink+of+%22Personalized+Surgery%22&rft.au=Rother%2C+Kristina+I%3BBrown%2C+Rebecca+J&rft.aulast=Rother&rft.aufirst=Kristina&rft.date=2011-01-01&rft.volume=96&rft.issue=6&rft.spage=1664&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Weight control; Surgery ER - TY - JOUR T1 - Semantic MEDLINE: An Advanced Information Management Application for Biomedicine AN - 907928389; 201109554 AB - To support more effective biomedical information management, Semantic MEDLINE integrates document retrieval, advanced natural language processing, automatic summarization and visualization into a single Web portal. The application is intended to help manage the results of PubMed searches by condensing core semantic content in the citations retrieved. Output is presented as a connected graph of semantic relations, with links to the original MEDLINE citations. The ability to connect salient information across documents helps users keep up with the research literature and discover connections which might otherwise go unnoticed. Semantic MEDLINE can make an impact on biomedicine by supporting scientific discovery and the timely translation of insights from basic research into advances in clinical practice and patient care. Semantic MEDLINE is illustrated here with recent research on the clock genes. Adapted from the source document. JF - Information Services & Use AU - Rindflesch, Thomas C AU - Kilicoglu, Halil AU - Fiszman, Marcelo AU - Rosemblat, Graciela AU - Shin, Dongwook AD - Lister Hill National Center for Biomedical Communications, National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894, USA tcr@nlm.nih.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 15 EP - 21 PB - IOS Press, Amsterdam, The Netherlands VL - 31 IS - 1-2 SN - 0167-5265, 0167-5265 KW - Biomedical information management, semantic processing, automatic summarization, graphical information representation, clock genes KW - MEDLINE KW - Natural language processing KW - Semantic relations KW - Online information retrieval KW - article KW - 13.13: AUTOMATIC TEXT ANALYSIS, AUTOMATIC INDEXING, MACHINE TRANSLATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907928389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Information+Services+%26+Use&rft.atitle=Semantic+MEDLINE%3A+An+Advanced+Information+Management+Application+for+Biomedicine&rft.au=Rindflesch%2C+Thomas+C%3BKilicoglu%2C+Halil%3BFiszman%2C+Marcelo%3BRosemblat%2C+Graciela%3BShin%2C+Dongwook&rft.aulast=Rindflesch&rft.aufirst=Thomas&rft.date=2011-01-01&rft.volume=31&rft.issue=1-2&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Information+Services+%26+Use&rft.issn=01675265&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2011-12-01 N1 - Last updated - 2016-09-27 N1 - CODEN - ISUSDX N1 - SubjectsTermNotLitGenreText - Online information retrieval; Natural language processing; Semantic relations; MEDLINE ER - TY - JOUR T1 - Zebrafish as a Model for Hemorrhagic Stroke AN - 907181891; 16046971 AB - Blood vessels perform the fundamental role of providing conduits for the circulation of oxygen and nutrients and the removal of waste products throughout the body. Disruption of tissue perfusion by ischemia or hemorrhage of blood vessels has a range of devastating consequences including stroke. Stroke is a complex trait that includes both genetic and environmental risk factors. The zebrafish is an attractive model for the study of hemorrhagic stroke due to the conservation of the molecular mechanisms of blood vascular development among vertebrates and the experimental advantages that can be applied to zebrafish embryos and larva. This chapter will focus on the maintenance of vascular integrity and some of the seminal experimentation carried out in the zebrafish. JF - Methods in Cell Biology AU - Butler, Matthew G AU - Gore, Aniket V AU - Weinstein, Brant M AD - Program in the Genomics of Differentiation, National Institute of Child Health and Development, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 137 EP - 161 PB - Elsevier B.V. VL - 105 SN - 0091-679X, 0091-679X KW - ASFA 1: Biological Sciences & Living Resources; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Blood vessel KW - Endothelial cell KW - Hemorrhagic KW - Homeostasis KW - Ischemia KW - Stroke KW - Molecular modelling KW - Perfusion KW - Wastes KW - Embryonic development KW - Nutrients KW - Freshwater KW - Hemorrhage KW - Freshwater fish KW - Larval development KW - Environmental factors KW - Danio rerio KW - Oxygen KW - Blood vessels KW - Haemorrhage KW - Risk factors KW - Cytology KW - Embryos KW - Modelling KW - Q1 08185:Genetics and evolution KW - W 30910:Imaging KW - N3 11007:Neurobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907181891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nuclear+Medicine&rft.atitle=18F-FPPRGD2+and+18F-FDG+PET+of+Response+to+Abraxane+Therapy&rft.au=Sun%2C+Xilin%3BYan%2C+Yongjun%3BLiu%2C+Shuanglong%3BCao%2C+Qizhen%3BYang%2C+Min%3BNeamati%2C+Nouri%3BShen%2C+Baozhong%3BNiu%2C+Gang%3BChen%2C+Xiaoyuan&rft.aulast=Sun&rft.aufirst=Xilin&rft.date=2011-01-01&rft.volume=52&rft.issue=1&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Haemorrhage; Blood vessels; Embryonic development; Wastes; Cytology; Larval development; Freshwater fish; Environmental factors; Modelling; Oxygen; Molecular modelling; Perfusion; Risk factors; Stroke; Nutrients; Embryos; Ischemia; Hemorrhage; Danio rerio; Freshwater DO - http://dx.doi.org/10.1016/B978-0-12-381320-6.00006-0 ER - TY - JOUR T1 - Cannabis in Sport: Anti-Doping Perspective AN - 907176488; 16061949 AB - Since 2004, when the World Anti-Doping Agency assumed the responsibility for establishing and maintaining the list of prohibited substances and methods in sport (i.e. the Prohibited List), cannabinoids have been prohibited in all sports during competition. The basis for this prohibition can be found in the World Anti-Doping Code, which defines the three criteria used to consider banning a substance. In this context, we discuss the potential of cannabis to enhance sports performance, the risk it poses to the athlete's health and its violation of the spirit of sport. Although these compounds are prohibited in-competition only, we explain why the pharmacokinetics of their main psychoactive compound, Delta super(9)-tetrahydrocannabinol, may complicate the results management of adverse analytical findings. Passive inhalation does not appear to be a plausible explanation for a positive test. Although the prohibition of cannabinoids in sports is one of the most controversial issues in anti-doping, in this review we stress the reasons behind this prohibition, with strong emphasis on the evolving knowledge of cannabinoid pharmacology. JF - Sports Medicine AU - Huestis, MA AU - Mazzoni, I AU - Rabin, O AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Boulevard, Suite 05-721, Baltimore, MD 21224, USA, mhuestis@intra.nida.nih.gov Y1 - 2011 PY - 2011 DA - 2011 SP - 949 EP - 966 VL - 41 IS - 11d SN - 0112-1642, 0112-1642 KW - Physical Education Index KW - Stress tests KW - Management KW - Stress KW - Health KW - Sports KW - Sports medicine KW - Competition KW - Knowledge KW - Perspective KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907176488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sports+Medicine&rft.atitle=Cannabis+in+Sport%3A+Anti-Doping+Perspective&rft.au=Huestis%2C+MA%3BMazzoni%2C+I%3BRabin%2C+O&rft.aulast=Huestis&rft.aufirst=MA&rft.date=2011-01-01&rft.volume=41&rft.issue=11d&rft.spage=949&rft.isbn=&rft.btitle=&rft.title=Sports+Medicine&rft.issn=01121642&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Stress tests; Management; Stress; Health; Sports medicine; Sports; Competition; Perspective; Knowledge ER - TY - JOUR T1 - Molecular characterization of the Borrelia burgdorferi in vivo-essential protein PncA AN - 907166949; 15786096 AB - The conversion of nicotinamide to nicotinic acid by nicotinamidase enzymes is a critical step in maintaining NAD+ homeostasis and contributes to numerous important biological processes in diverse organisms. In Borrelia burgdorferi, the nicotinamidase enzyme, PncA, is required for spirochaete survival throughout the infectious cycle. Mammals lack nicotinamidases and therefore PncA may serve as a therapeutic target for Lyme disease. Contrary to the in vivo importance of PncA, the current annotation for the pncA ORF suggests that the encoded protein may be inactive due to the absence of an N-terminal aspartic acid residue that is a conserved member of the catalytic triad of characterized PncA proteins. Herein, we have used genetic and biochemical strategies to determine the N-terminal sequence of B. burgdorferi PncA. Our data demonstrate that the PncA protein is 24 aa longer than the currently annotated sequence and that pncA translation is initiated from the rare, non-canonical initiation codon AUU. These findings are an important first step in understanding the catalytic function of this in vivo-essential protein. JF - Microbiology AU - Jewett, Mollie W AU - Jain, Sunny AU - Linowski, Angelika K AU - Sarkar, Amit AU - Rosa, Patricia A AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 2831 EP - 2840 PB - Society for General Microbiology, Marlborough House, Basingstoke Road Reading RG7 1AG United Kingdom VL - 157 SN - 1350-0872, 1350-0872 KW - Microbiology Abstracts B: Bacteriology KW - Nicotinamidase KW - Translation KW - Data processing KW - Aspartic acid KW - Borrelia burgdorferi KW - nicotinamide KW - Enzymes KW - Survival KW - Homeostasis KW - Nicotinic acid KW - Codons KW - Open reading frames KW - Lyme disease KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907166949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology&rft.atitle=Molecular+characterization+of+the+Borrelia+burgdorferi+in+vivo-essential+protein+PncA&rft.au=Jewett%2C+Mollie+W%3BJain%2C+Sunny%3BLinowski%2C+Angelika+K%3BSarkar%2C+Amit%3BRosa%2C+Patricia+A&rft.aulast=Jewett&rft.aufirst=Mollie&rft.date=2011-01-01&rft.volume=157&rft.issue=&rft.spage=2831&rft.isbn=&rft.btitle=&rft.title=Microbiology&rft.issn=13500872&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Nicotinamidase; Translation; Aspartic acid; Data processing; nicotinamide; Codons; Survival; Enzymes; Homeostasis; Nicotinic acid; Open reading frames; Lyme disease; Borrelia burgdorferi ER - TY - JOUR T1 - From Endocrine Disruptors To Nanomaterials: Advancing Our Understanding Of Environmental Health To Protect Public Health AN - 907163025; 14811728 AB - Environmental health science is the study of the impact of the environment on human health. This paper introduces basic topics in environmental health, including clean air, clean water, and healthful food, as well as a range of current issues and controversies in environmental health. Conceptual shifts in modern toxicology have changed the field. There is a new understanding of the effects of exposure to chemicals at low doses, and in combination, and the impact on human growth and development. Other emerging topics include the role of epigenetics, or changes in genes and gene expression that can be brought about by chemical exposure; environmental justice; and potential effects of engineered nanomaterials and climate change. We review the important implications for public health policy and recommend a broad environmental health research strategy aimed at protecting and improving human health. JF - Health Affairs AU - Birnbaum, Linda S AU - Jung, Paul AD - Linda S. Birnbaum is director of the National Institute of Environmental Health Sciences and National Toxicology Program in Research Triangle Park, North Carolina. Paul Jung is chief of staff of the National Institute of Environmental Health Sciences., birnbaumls@niehs.nih.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 814 EP - 822 PB - Project Hope, 7500 Old Georgetown Rd. Suite 600 Bethesda MD 20814-6133 USA VL - 30 IS - 5 SN - 0278-2715, 0278-2715 KW - Sustainability Science Abstracts; Health & Safety Science Abstracts; Environment Abstracts KW - Chemicals KW - endocrine disruptors KW - Reviews KW - Climate change KW - Environmental health KW - Research programs KW - Toxicology KW - Public health KW - nanotechnology KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - M3 1010:Issues in Sustainable Development KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907163025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nuclear+Medicine&rft.atitle=Lognormal+Distribution+of+Cellular+Uptake+of+Radiopharmaceuticals%3A+Implications+for+Biologic+Response+in+Cancer+Treatment&rft.au=Zanotti-Fregonara%2C+Paolo%3BHindie%2C+Elif&rft.aulast=Zanotti-Fregonara&rft.aufirst=Paolo&rft.date=2011-01-01&rft.volume=52&rft.issue=4&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Chemicals; endocrine disruptors; Reviews; Climate change; Environmental health; Toxicology; Research programs; nanotechnology; Public health ER - TY - JOUR T1 - Gene Expression, Biomarkers, and Glial Cells in Nervous System Diseases AN - 907159886; 14454630 AB - Session 3 of the "Toxicologic Neuropathology" Symposium sponsored jointly by the Society of Toxicologic Pathology (STP) and the International Federation of Societies of Toxicologic Pathologists (IFSTP) focused on advances in the understanding of cellular and molecular mechanisms of the nervous system and neurodegenerative diseases, and on new information on the function and roles of microglia cells and astrocytes. This overview highlights the major themes of the presentations in General Session 3; these themes are covered in greater detail in four papers in this issue of Toxicologic Pathology. JF - Toxicologic Pathology AU - Sills, Robert C AU - Garman, Robert H AD - National Toxicology Program, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 97 EP - 98 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 39 IS - 1 SN - 0192-6233, 0192-6233 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Astrocytes KW - Gene expression KW - Glial cells KW - Microglia KW - Molecular modelling KW - Nervous system KW - Nervous system diseases KW - Neurodegenerative diseases KW - Neuropathology KW - Reviews KW - biomarkers KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907159886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Gene+Expression%2C+Biomarkers%2C+and+Glial+Cells+in+Nervous+System+Diseases&rft.au=Sills%2C+Robert+C%3BGarman%2C+Robert+H&rft.aulast=Sills&rft.aufirst=Robert&rft.date=2011-01-01&rft.volume=39&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Gene expression; Neurodegenerative diseases; Molecular modelling; Nervous system; Astrocytes; Reviews; Glial cells; Nervous system diseases; Microglia; biomarkers; Neuropathology ER - TY - JOUR T1 - A Proteomic and Transcriptomic Approach Reveals New Insight into beta -methylthiolation of Escherichia coli Ribosomal Protein S12 AN - 907157444; 14453172 AB - beta -methylthiolation is a novel post-translational modification mapping to a universally conserved Asp 88 of the bacterial ribosomal protein S12. This S12 specific modification has been identified on orthologs from multiple bacterial species. The origin and functional significance was investigated with both a proteomic strategy to identify candidate S12 interactors and expression microarrays to search for phenotypes that result from targeted gene knockouts of select candidates. Utilizing an endogenous recombinant E. coli S12 protein with an affinity tag as bait, mass spectrometric analysis identified candidate S12 binding partners including RimO (previously shown to be required for this post-translational modification) and YcaO, a conserved protein of unknown function. Transcriptomic analysis of bacterial strains with deleted genes for RimO and YcaO identified an overlapping transcriptional phenotype suggesting that YcaO and RimO likely share a common function. As a follow up, quantitative mass spectrometry additionally indicated that both proteins dramatically impacted the modification status of S12. Collectively, these results indicate that the YcaO protein is involved in beta -methylthiolation of S12 and its absence impairs the ability of RimO to modify S12. Additionally, the proteomic data from this study provides direct evidence that the E. coli specific beta -methylthiolation likely occurs when S12 is assembled as part of a ribosomal subunit. JF - Molecular and Cellular Proteomics AU - Strader, Michael Brad AU - Costantino, Nina AU - Elkins, Christopher A AU - Chen, Cai Yun AU - Patel, Isha AU - Makusky, Anthony J AU - Choy, John S AU - Court, Donald L AU - Markey, Sanford P AU - Kowalak, Jeffrey A AD - From the Laboratory of Neurotoxicology, National Institute of Mental Health, Bethesda, MD 20892, USA. National Cancer Institute/Frederick Cancer Research and Development Center, Frederick, MD 21702, USA. U.S. Food and Drug Administration, Laurel MD 20708, USA. Y1 - 2011 PY - 2011 DA - 2011 SP - M110.005199 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 10 IS - 3 SN - 1535-9476, 1535-9476 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - DNA microarrays KW - Data processing KW - Mass spectroscopy KW - Peptide mapping KW - Post-translation KW - Ribosomal subunits KW - Transcription KW - proteomics KW - ribosomal protein S12 KW - Escherichia coli KW - J 02310:Genetics & Taxonomy KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907157444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Proteomics&rft.atitle=A+Proteomic+and+Transcriptomic+Approach+Reveals+New+Insight+into+beta+-methylthiolation+of+Escherichia+coli+Ribosomal+Protein+S12&rft.au=Strader%2C+Michael+Brad%3BCostantino%2C+Nina%3BElkins%2C+Christopher+A%3BChen%2C+Cai+Yun%3BPatel%2C+Isha%3BMakusky%2C+Anthony+J%3BChoy%2C+John+S%3BCourt%2C+Donald+L%3BMarkey%2C+Sanford+P%3BKowalak%2C+Jeffrey+A&rft.aulast=Strader&rft.aufirst=Michael&rft.date=2011-01-01&rft.volume=10&rft.issue=3&rft.spage=M110.005199&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Proteomics&rft.issn=15359476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Data processing; ribosomal protein S12; Peptide mapping; Post-translation; Transcription; Ribosomal subunits; proteomics; DNA microarrays; Mass spectroscopy; Escherichia coli ER - TY - JOUR T1 - Neutrophil responses to staphylococcal pathogens and commensals via the formyl peptide receptor 2 relates to phenol-soluble modulin release and virulence AN - 907157147; 14624504 AB - The mechanisms used by the immune system to discriminate between pathogenic and commensal bacteria have remained largely unclear. Recently, we have shown that virulence of Staphylococcus aureus depends on secretion of phenol-soluble modulin (PSM) peptides that disrupt neutrophils at micromolar concentrations. Moreover, all S. aureus PSMs stimulate and attract neutrophils at nanomolar concentrations via interaction with the formyl-peptide receptor 2 (FPR2). Here, we demonstrate that FPR2 allows neutrophils to adjust their responses in relation to the aggressiveness of staphylococcal species, which differ largely in their capacity to infect or colonize humans and animals. PSM-related peptides were detected in all human and animal pathogenic staphylococci, but were absent from most commensal species. Three PSM beta -like peptides produced by the serious human pathogen Staphylococcus lugdunensis were identified as the previously described S. lugdunensis-synergistic hemolysins (SLUSHs). SLUSHs attracted and stimulated human leukocytes in a FPR2-dependent manner, indicating that FPR2 is a general receptor for all PSM-like peptide toxins. Remarkably, the release of PSMs correlated closely with the apparent capacity of staphylococcal species to cause invasive infections and with their ability to activate FPR2. These findings suggest that the innate immune system may be able to respond in different ways to pathogenic or innocuous staphylococci by monitoring the presence of PSMs via FPR2.-Rautenberg, M., Joo, H. S., Otto, M., Peschel, A. Neutrophil responses to staphylococcal pathogens and commensals via the formyl peptide receptor 2 relates to phenol-soluble modulin release and virulence. JF - FASEB Journal AU - Rautenberg, Maren AU - Joo, Hwang-Soo AU - Otto, Michael AU - Peschel, Andreas AD - Cellular and Molecular Microbiology Division, Interfaculty Institute of Microbiology and Infection Medicine, University of Tuebingen, Tuebingen, Germany. Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, U.S. National Institutes of Health, Bethesda, Maryland, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 1254 EP - 1263 PB - Federation of American Societies for Experimental Biology, 9650 Rockville Pike Bethesda MD 20814 USA VL - 25 IS - 4 SN - 0892-6638, 0892-6638 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - formyl peptides KW - Immune system KW - Leukocytes (neutrophilic) KW - Commensals KW - Pathogens KW - Infection KW - Toxins KW - formyl peptide receptors KW - Virulence KW - Staphylococcus lugdunensis KW - Staphylococcus aureus KW - Hemolysins KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907157147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+Journal&rft.atitle=Neutrophil+responses+to+staphylococcal+pathogens+and+commensals+via+the+formyl+peptide+receptor+2+relates+to+phenol-soluble+modulin+release+and+virulence&rft.au=Rautenberg%2C+Maren%3BJoo%2C+Hwang-Soo%3BOtto%2C+Michael%3BPeschel%2C+Andreas&rft.aulast=Rautenberg&rft.aufirst=Maren&rft.date=2011-01-01&rft.volume=25&rft.issue=4&rft.spage=1254&rft.isbn=&rft.btitle=&rft.title=FASEB+Journal&rft.issn=08926638&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Virulence; formyl peptides; Immune system; Commensals; Leukocytes (neutrophilic); Pathogens; Infection; Hemolysins; Toxins; formyl peptide receptors; Staphylococcus lugdunensis; Staphylococcus aureus ER - TY - JOUR T1 - Erythropoietin-driven proliferation of cells with mutations in the tumor suppressor gene TSC2 AN - 907156087; 14153763 AB - Lymphangioleiomyomatosis (LAM) is characterized by cystic lung destruction, resulting from proliferation of smooth-muscle-like cells, which have mutations in the tumor suppressor genes TSC1 or TSC2. Among 277 LAM patients, severe disease was associated with hypoxia and elevated red blood cell indexes that accompanied reduced pulmonary function. Because high red cell indexes could result from hypoxemia-induced erythropoietin (EPO) production, and EPO is a smooth muscle cell mitogen, we investigated effects of EPO in human cells with genetic loss of tuberin function, and we found that EPO increased proliferation of human TSC2-/-, but not of TSC2+/-, cells. A discrete population of cells grown from explanted lungs was characterized by the presence of EPO receptor and loss of heterozygosity for TSC2, consistent with EPO involvement. In LAM cells from lung nodules, EPO was localized to the extracellular matrix, supporting evidence for activation of an EPO-driven signaling pathway. Although the high red cell mass of LAM patients could be related to advanced disease, we propose that EPO, synthesized in response to episodic hypoxia, may increase disease progression by enhancing the proliferation of LAM cells. JF - American Journal of Physiology: Lung Cellular and Molecular Physiology AU - Ikeda, Yoshihiko AU - Taveira-DaSilva, Angelo M AU - Pacheco-Rodriguez, Gustavo AU - Steagall, Wendy K AU - El-Chemaly, Souheil AU - Gochuico, Bernadette R AU - May, Rose M AU - Hathaway, Olanda M AU - Li, Shaowei AU - Wang, Ji-an AU - Darling, Thomas N AU - Stylianou, Mario AU - Moss, Joel AD - Cardiovascular and Pulmonary Branch, Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, and Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - L64 EP - L72 PB - American Physiological Society, 9650 Rockville Pike Bethesda MD 20814-3991 USA VL - 300 IS - 1 SN - 1040-0605, 1040-0605 KW - Genetics Abstracts; Toxicology Abstracts; Oncogenes & Growth Factors Abstracts KW - Smooth muscle KW - Tumor suppressor genes KW - Tuberous sclerosis 2 protein KW - Tuberin KW - Erythrocytes KW - Lung nodules KW - Hamartin KW - Loss of heterozygosity KW - Erythropoietin KW - Extracellular matrix KW - Hypoxia KW - Mitogens KW - Cell proliferation KW - Mutation KW - Signal transduction KW - X 24310:Pharmaceuticals KW - B 26670:Tumor Suppressors KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907156087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Physiology%3A+Lung+Cellular+and+Molecular+Physiology&rft.atitle=Erythropoietin-driven+proliferation+of+cells+with+mutations+in+the+tumor+suppressor+gene+TSC2&rft.au=Ikeda%2C+Yoshihiko%3BTaveira-DaSilva%2C+Angelo+M%3BPacheco-Rodriguez%2C+Gustavo%3BSteagall%2C+Wendy+K%3BEl-Chemaly%2C+Souheil%3BGochuico%2C+Bernadette+R%3BMay%2C+Rose+M%3BHathaway%2C+Olanda+M%3BLi%2C+Shaowei%3BWang%2C+Ji-an%3BDarling%2C+Thomas+N%3BStylianou%2C+Mario%3BMoss%2C+Joel&rft.aulast=Ikeda&rft.aufirst=Yoshihiko&rft.date=2011-01-01&rft.volume=300&rft.issue=1&rft.spage=L64&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Physiology%3A+Lung+Cellular+and+Molecular+Physiology&rft.issn=10400605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-04-06 N1 - SubjectsTermNotLitGenreText - Smooth muscle; Tumor suppressor genes; Tuberous sclerosis 2 protein; Tuberin; Erythrocytes; Lung nodules; Hamartin; Loss of heterozygosity; Erythropoietin; Hypoxia; Extracellular matrix; Mitogens; Cell proliferation; Mutation; Signal transduction ER - TY - JOUR T1 - The trans-Golgi SNARE syntaxin 6 is recruited to the chlamydial inclusion membrane AN - 907155254; 14453202 AB - Chlamydia trachomatis is an obligate intracellular pathogen that replicates within a parasitophorous vacuole termed an inclusion. The chlamydial inclusion is isolated from the endocytic pathway but fusogenic with Golgi-derived exocytic vesicles containing sphingomyelin and cholesterol. Sphingolipids are incorporated into the chlamydial cell wall and are considered essential for chlamydial development and viability. The mechanisms by which chlamydiae obtain eukaryotic lipids are poorly understood but require chlamydial protein synthesis and presumably modification of the inclusion membrane to initiate this interaction. A polarized cell model of chlamydial infection has demonstrated that chlamydiae preferentially intercept basolaterally directed, sphingomyelin-containing exocytic vesicles. Here we examine the localization and potential function of trans-Golgi and/or basolaterally associated soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins in chlamydia-infected cells. The trans-Golgi SNARE protein syntaxin 6 is recruited to the chlamydial inclusion in a manner that requires chlamydial protein synthesis and is conserved among all chlamydial species examined. The localization of syntaxin 6 to the chlamydial inclusion requires a tyrosine motif or plasma membrane retrieval signal (YGRL). Thus in addition to expression of at least two inclusion membrane proteins that contain SNARE-like motifs, chlamydiae also actively recruit eukaryotic SNARE-family proteins. JF - Microbiology AU - Moore, Elizabeth R AU - Mead, David J AU - Dooley, Cheryl A AU - Sager, Janet AU - Hackstadt, Ted AD - Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 830 EP - 838 PB - Society for General Microbiology, Marlborough House, Basingstoke Road Reading RG7 1AG UK VL - 157 SN - 1350-0872, 1350-0872 KW - Microbiology Abstracts B: Bacteriology KW - Protein biosynthesis KW - Receptor mechanisms KW - sphingomyelin KW - Lipids KW - Chlamydia trachomatis KW - Tyrosine KW - Syntaxin KW - Cell culture KW - Membrane proteins KW - Pathogens KW - Cholesterol KW - N-Ethylmaleimide-sensitive protein KW - Infection KW - SNAP receptors KW - parasitophorous vacuole KW - Plasma membranes KW - Sphingolipids KW - Vesicles KW - Cell walls KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907155254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology&rft.atitle=The+trans-Golgi+SNARE+syntaxin+6+is+recruited+to+the+chlamydial+inclusion+membrane&rft.au=Moore%2C+Elizabeth+R%3BMead%2C+David+J%3BDooley%2C+Cheryl+A%3BSager%2C+Janet%3BHackstadt%2C+Ted&rft.aulast=Moore&rft.aufirst=Elizabeth&rft.date=2011-01-01&rft.volume=157&rft.issue=&rft.spage=830&rft.isbn=&rft.btitle=&rft.title=Microbiology&rft.issn=13500872&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Protein biosynthesis; sphingomyelin; Receptor mechanisms; Lipids; Syntaxin; Tyrosine; Cell culture; Cholesterol; Pathogens; Membrane proteins; Infection; N-Ethylmaleimide-sensitive protein; SNAP receptors; parasitophorous vacuole; Plasma membranes; Sphingolipids; Vesicles; Cell walls; Chlamydia trachomatis ER - TY - JOUR T1 - Auranofin Protects against Anthrax Lethal Toxin-Induced Activation of the Nlrp1b Inflammasome AN - 907153097; 14403432 AB - Anthrax lethal toxin (LT) is the major virulence factor for Bacillus anthracis. The lethal factor (LF) component of this bipartite toxin is a protease which, when transported into the cellular cytoplasm, cleaves mitogen-activated protein kinase kinase (MEK) family proteins and induces rapid toxicity in mouse macrophages through activation of the Nlrp1b inflammasome. A high-throughput screen was performed to identify synergistic LT-inhibitory drug combinations from within a library of approved drugs and molecular probes. From this screen we discovered that auranofin, an organogold compound with anti-inflammatory activity, strongly inhibited LT-mediated toxicity in mouse macrophages. Auranofin did not inhibit toxin transport into cells or MEK cleavage but inhibited both LT-mediated caspase-1 activation and caspase-1 catalytic activity. Thus, auranofin inhibited LT-mediated toxicity by preventing activation of the Nlrp1b inflammasome and the downstream actions that occur in response to the toxin. Idebenone, an analog of coenzyme Q, synergized with auranofin to increase its protective effect. We found that idebenone functions as an inhibitor of voltage-gated potassium channels and thus likely mediates synergy through inhibition of the potassium fluxes which have been shown to be required for Nlrp1b inflammasome activation. JF - Antimicrobial Agents & Chemotherapy AU - Newman, Zachary L AU - Sirianni, Nicole AU - Mawhinney, Christina AU - Lee, Margaret S AU - Leppla, Stephen H AU - Moayeri, Mahtab AU - Johansen, Lisa M AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 1028 EP - 1035 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 55 IS - 3 SN - 0066-4804, 0066-4804 KW - Toxicology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Anthrax KW - Anthrax lethal toxin KW - Antiinflammatory agents KW - Caspase-1 KW - Cell activation KW - Cytoplasm KW - Drugs KW - Lethal factor KW - MAP kinase KW - Macrophages KW - Potassium channels (voltage-gated) KW - Probes KW - Proteinase KW - Toxicity KW - coenzyme Q KW - virulence factors KW - Bacillus anthracis KW - A 01340:Antibiotics & Antimicrobials KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907153097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Auranofin+Protects+against+Anthrax+Lethal+Toxin-Induced+Activation+of+the+Nlrp1b+Inflammasome&rft.au=Newman%2C+Zachary+L%3BSirianni%2C+Nicole%3BMawhinney%2C+Christina%3BLee%2C+Margaret+S%3BLeppla%2C+Stephen+H%3BMoayeri%2C+Mahtab%3BJohansen%2C+Lisa+M&rft.aulast=Newman&rft.aufirst=Zachary&rft.date=2011-01-01&rft.volume=55&rft.issue=3&rft.spage=1028&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Macrophages; Anthrax lethal toxin; MAP kinase; virulence factors; Lethal factor; Probes; Toxicity; Cell activation; Cytoplasm; Potassium channels (voltage-gated); Anthrax; Caspase-1; Proteinase; coenzyme Q; Drugs; Antiinflammatory agents; Bacillus anthracis ER - TY - JOUR T1 - Mutational and biochemical analysis of the DNA-entry nuclease EndA from Streptococcus pneumoniae AN - 907150034; 14268295 AB - EndA is a membrane-attached surface-exposed DNA-entry nuclease previously known to be required for genetic transformation of Streptococcus pneumoniae. More recent studies have shown that the enzyme also plays an important role during the establishment of invasive infections by degrading extracellular chromatin in the form of neutrophil extracellular traps (NETs), enabling streptococci to overcome the innate immune system in mammals. As a virulence factor, EndA has become an interesting target for future drug design. Here we present the first mutational and biochemical analysis of recombinant forms of EndA produced either in a cell-free expression system or in Escherichia coli. We identify His160 and Asn191 to be essential for catalysis and Asn182 to be required for stability of EndA. The role of His160 as the putative general base in the catalytic mechanism is supported by chemical rescue of the H160A variant of EndA with imidazole added in excess. Our study paves the way for the identification and development of protein or low-molecular-weight inhibitors for EndA in future high-throughput screening assays. JF - Nucleic Acids Research AU - Midon, Marika AU - Schaefer, Patrick AU - Pingoud, Alfred AU - Ghosh, Mahua AU - Moon, Andrea F AU - Cuneo, Matthew J AU - London, Robert E AU - Meiss, Gregor AD - Institute of Biochemistry, Justus-Liebig-University Giessen, Heinrich-Buff-Ring 58, D-35392 Giessen, Germany, Indian Institute of Science Education and Research, Kolkata Mohanpur Campus, Mohanpur 741252, West Bengal, India and Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 623 EP - 634 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 39 IS - 2 SN - 1362-4962, 1362-4962 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Transformation KW - imidazole KW - Chromatin KW - virulence factors KW - Immune system KW - Leukocytes (neutrophilic) KW - Enzymes KW - Nuclease KW - Biochemical analysis KW - Drug development KW - Infection KW - Immunosuppressive agents KW - Streptococcus pneumoniae KW - Escherichia coli KW - high-throughput screening KW - Catalysis KW - J 02310:Genetics & Taxonomy KW - N 14820:DNA Metabolism & Structure KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907150034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Mutational+and+biochemical+analysis+of+the+DNA-entry+nuclease+EndA+from+Streptococcus+pneumoniae&rft.au=Midon%2C+Marika%3BSchaefer%2C+Patrick%3BPingoud%2C+Alfred%3BGhosh%2C+Mahua%3BMoon%2C+Andrea+F%3BCuneo%2C+Matthew+J%3BLondon%2C+Robert+E%3BMeiss%2C+Gregor&rft.aulast=Midon&rft.aufirst=Marika&rft.date=2011-01-01&rft.volume=39&rft.issue=2&rft.spage=623&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=13624962&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Transformation; imidazole; virulence factors; Chromatin; Immune system; Leukocytes (neutrophilic); Biochemical analysis; Nuclease; Enzymes; Drug development; Infection; Immunosuppressive agents; high-throughput screening; Catalysis; Streptococcus pneumoniae; Escherichia coli ER - TY - JOUR T1 - Rosai-Dorfman Disease in Neuroradiology: Imaging Findings in a Series of 10 Patients AN - 907149612; 14267458 AB - OBJECTIVE: Rosai-Dorfman disease is a rare disorder characterized histologically by lymphatic sinus dilatation due to histiocyte proliferation. Our goal was to describe the CT, MRI, and 18F-FDG (FDG) PET findings in a series of patients with this diagnosis. MATERIALS AND METHODS: We retrospectively reviewed the imaging studies of 10 patients with pathologically confirmed Rosai-Dorfman disease who were treated in our institution between January 2004 and December 2007. RESULTS: We found the following areas of general involvement: three intracranial, seven head and neck, and three spinal, with some patients having more than one site. Specific sites of involvement included the following: intracranial meninges, n = 2; pituitary, n = 2; lacrimal gland, n = 1; paranasal sinus, n = 3; neck lymph nodes, n = 6; salivary gland, n = 3; tonsil, n = 1; skin, n = 1; spinal meninges, n = 2; vertebral body, n = 1; and thymus, n = 1. The MRI characteristics of the involved areas were generally T1 isointense, T2 isointense, diffusion isointense to gray matter, and intensely enhancing with gadolinium chelate contrast agents. CT images generally showed the lesions were hyperdense to gray matter and intensely enhancing. FDG PET showed variable uptake, with nodal and lacrimal disease generally being FDG avid and other sites not. CONCLUSION: Rosai-Dorfman disease has a protean imaging appearance but most frequently presents as neck lymphadenopathy. The disease is frequently multifocal, and a diagnosis in one area should prompt suspicion that other sites may be involved also. JF - American Journal of Roentgenology AU - Raslan, Osama A AU - Schellingerhout, Dawid AU - Fuller, Gregory N AU - Ketonen, Leena M AD - Department of Diagnostic Radiology, National Cancer Institute, CairoUniversity, Cairo, Egypt Y1 - 2011 PY - 2011 DA - 2011 SP - W187 EP - W193 PB - American Roentgen Ray Society VL - 196 IS - 2 SN - 0361-803X, 0361-803X KW - Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Thymus KW - Magnetic resonance imaging KW - Gadolinium KW - Paranasal sinus KW - Sinus KW - Neck KW - Vertebrae KW - Meninges KW - Lymphadenopathy KW - Tonsil KW - Pituitary KW - Computed tomography KW - Positron emission tomography KW - Contrast media KW - Diffusion KW - Chelates KW - Head and neck KW - Substantia grisea KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907149612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Roentgenology&rft.atitle=Rosai-Dorfman+Disease+in+Neuroradiology%3A+Imaging+Findings+in+a+Series+of+10+Patients&rft.au=Raslan%2C+Osama+A%3BSchellingerhout%2C+Dawid%3BFuller%2C+Gregory+N%3BKetonen%2C+Leena+M&rft.aulast=Raslan&rft.aufirst=Osama&rft.date=2011-01-01&rft.volume=141&rft.issue=2&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Gadolinium; Magnetic resonance imaging; Thymus; Paranasal sinus; Sinus; Neck; Vertebrae; Meninges; Lymphadenopathy; Tonsil; Pituitary; Computed tomography; Contrast media; Positron emission tomography; Diffusion; Chelates; Head and neck; Substantia grisea ER - TY - JOUR T1 - High-Throughput Giardia lamblia Viability Assay Using Bioluminescent ATP Content Measurements AN - 907149122; 14267406 AB - The human pathogen Giardia lamblia is an anaerobic protozoan parasite that causes giardiasis, one of the most common diarrheal diseases worldwide. Although several drugs are available for the treatment of giardiasis, drug resistance has been reported and is likely to increase, and recurrent infections are common. The search for new drugs that can overcome the drug-resistant strains of Giardia is an unmet medical need. New drug screen methods can facilitate the drug discovery process and aid with the identification of new drug targets. Using a bioluminescent ATP content assay, we have developed a phenotypic drug screen method to identify compounds that act against the actively growing trophozoite stage of the parasite. This assay is homogeneous, robust, and suitable for high-throughput screening of large compound collections. A screen of 4,096 pharmacologically active small molecules and approved drugs revealed 43 compounds with selective anti-Giardia properties, including 32 previously reported and 11 novel anti-Giardia agents. The most potent novel compound was fumagillin, which showed 50% inhibitory concentrations of 10 nM against the WB isolate and 2 nM against the GS isolate. JF - Antimicrobial Agents & Chemotherapy AU - Chen, Catherine Z AU - Kulakova, Liudmila AU - Southall, Noel AU - Marugan, Juan J AU - Galkin, Andrey AU - Austin, Christopher P AU - Herzberg, Osnat AU - Zheng, Wei AD - NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2011 PY - 2011 DA - 2011 SP - 667 EP - 675 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 55 IS - 2 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Diarrhea KW - Drug resistance KW - Giardia lamblia KW - ATP KW - Giardiasis KW - Pathogens KW - Drug discovery KW - Recurrent infection KW - high-throughput screening KW - Drugs KW - Trophozoites KW - K 03340:Effects of Physical & Chemical Factors KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907149122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=High-Throughput+Giardia+lamblia+Viability+Assay+Using+Bioluminescent+ATP+Content+Measurements&rft.au=Chen%2C+Catherine+Z%3BKulakova%2C+Liudmila%3BSouthall%2C+Noel%3BMarugan%2C+Juan+J%3BGalkin%2C+Andrey%3BAustin%2C+Christopher+P%3BHerzberg%2C+Osnat%3BZheng%2C+Wei&rft.aulast=Chen&rft.aufirst=Catherine&rft.date=2011-01-01&rft.volume=55&rft.issue=2&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Drug discovery; Parasites; Diarrhea; Drug resistance; ATP; high-throughput screening; Recurrent infection; Pathogens; Giardiasis; Drugs; Trophozoites; Giardia lamblia ER - TY - JOUR T1 - Shared Molecular Strategies of the Malaria Parasite P. falciparum and the Human Virus HIV-1 AN - 904494403; 15840131 AB - We augmented existing computationally predicted and experimentally determined interactions with evolutionarily conserved interactions between proteins of the malaria parasite, P. falciparum, and the human host. In a validation step, we found that conserved interacting host-parasite protein pairs were specifically expressed in host tissues where both the parasite and host proteins are known to be active. We compared host-parasite interactions with experimentally verified interactions between human host proteins and a very different pathogen, HIV-1. Both pathogens were found to use their protein repertoire in a combinatorial manner, providing a broad connection to host cellular processes. Specifically, the two biologically distinct pathogens predominately target central proteins to take control of a human host cell, effectively reaching into diversified cellular host cellular functions. Interacting signaling pathways and a small set of regulatory and signaling proteins were prime targets of both pathogens, suggesting remarkably similar patterns of host-pathogen interactions despite the vast biological differences of both pathogens. Such an identification of shared molecular strategies by the virus HIV-1 and the eukaryotic intracellular pathogen P. falciparum may allow us to illuminate new avenues of disease intervention. JF - Molecular and Cellular Proteomics AU - Wuchty, Stefan AU - Siwo, Geoffrey H AU - Ferdig, Michael T AD - From the National Center of Biotechnology Information, National Institutes of Health, Bethesda, MD 20892 Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - M111.009035 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 United States VL - 10 IS - 10 SN - 1535-9476, 1535-9476 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; Virology & AIDS Abstracts KW - Parasites KW - Human diseases KW - Malaria KW - Plasmodium falciparum KW - Hosts KW - Pathogens KW - Public health KW - Host-pathogen interactions KW - Human immunodeficiency virus 1 KW - proteomics KW - Host-parasite interactions KW - Evolution KW - Signal transduction KW - V 22360:AIDS and HIV KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904494403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Proteomics&rft.atitle=Shared+Molecular+Strategies+of+the+Malaria+Parasite+P.+falciparum+and+the+Human+Virus+HIV-1&rft.au=Wuchty%2C+Stefan%3BSiwo%2C+Geoffrey+H%3BFerdig%2C+Michael+T&rft.aulast=Wuchty&rft.aufirst=Stefan&rft.date=2011-01-01&rft.volume=10&rft.issue=10&rft.spage=M111.009035&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Proteomics&rft.issn=15359476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Malaria; Pathogens; Hosts; Public health; Host-pathogen interactions; proteomics; Host-parasite interactions; Evolution; Signal transduction; Human immunodeficiency virus 1; Plasmodium falciparum ER - TY - JOUR T1 - Advanced Glycation End Products, Soluble Receptor for Advanced Glycation End Products, and Risk of Colorectal Cancer AN - 904487511; 15209818 AB - BACKGROUND: Advanced glycation end products (AGE) accumulate in human tissue proteins during aging, particularly under hyperglycemia conditions. AGEs induce oxidative stress and inflammation via the receptor for AGEs (RAGE) and soluble RAGE (sRAGE) can neutralize the effects mediated by RAGE-ligand engagement. METHODS: We examined the association between N epsilon -(carboxymethyl)lysine (CML), a prominent AGE, and sRAGE and colorectal cancer risk in a prospective case-cohort study nested within a cancer prevention trial among 29,133 Finnish male smokers. Among study subjects who were alive without cancer 5 years after baseline (1985-1988), we identified 483 incident colorectal cancer cases and randomly sampled 485 subcohort participants as the comparison group with the follow-up to April 2006. Baseline serum levels of CML-AGE, sRAGE, glucose and insulin were determined. Weighted Cox proportional hazard regression models were used to calculate relative risks (RR) and 95% CI. RESULTS: Comparing highest with lowest quintile of sRAGE, the RR for incident colorectal cancer was 0.65 (95% CI, 0.39-1.07; Ptrend = 0.03), adjusting for age, years of smoking, body mass index, and CML-AGE. Further adjustment for serum glucose strengthened the association (RR = 0.52; 95% CI, 0.30-0.89; Ptrend = 0.009). Highest quintile of CML-AGE was not associated with an increased risk of colorectal cancer (multivariate RR = 1.20; 95% CI, 0.64-2.26). CONCLUSIONS: Higher prediagnostic levels of serum sRAGE were associated with lower risk of colorectal cancer in male smokers. IMPACT: This is the first epidemiologic study to implicate the receptor for AGEs in colorectal cancer development. Cancer Epidemiol Biomarkers Prev; 20(7); 1430-8. [copy ]2011 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Jiao, Li AU - Taylor, Philip R AU - Weinstein, Stephanie J AU - Graubard, Barry I AU - Virtamo, Jarmo AU - Albanes, Demetrius AU - Stolzenberg-Solomon, Rachael Z AD - Authors' Affiliations: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland and Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland Y1 - 2011 PY - 2011 DA - 2011 SP - 1430 EP - 1438 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States VL - 20 IS - 7 SN - 1055-9965, 1055-9965 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Aging KW - Bioindicators KW - Body mass KW - Cancer KW - Oxidative stress KW - Prevention KW - Proteins KW - aging KW - body mass KW - colorectal carcinoma KW - insulin KW - prevention KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904487511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Advanced+Glycation+End+Products%2C+Soluble+Receptor+for+Advanced+Glycation+End+Products%2C+and+Risk+of+Colorectal+Cancer&rft.au=Jiao%2C+Li%3BTaylor%2C+Philip+R%3BWeinstein%2C+Stephanie+J%3BGraubard%2C+Barry+I%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius%3BStolzenberg-Solomon%2C+Rachael+Z&rft.aulast=Jiao&rft.aufirst=Li&rft.date=2011-01-01&rft.volume=20&rft.issue=7&rft.spage=1430&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Bioindicators; Age; insulin; Body mass; Aging; Cancer; Prevention; colorectal carcinoma; body mass; Oxidative stress; prevention; Proteins; aging ER - TY - JOUR T1 - A Long-term Prospective Study of Type-Specific Human Papillomavirus Infection and Risk of Cervical Neoplasia Among 20,000 Women in the Portland Kaiser Cohort Study AN - 904484106; 15209813 AB - BACKGROUND: Human papillomavirus (HPV) DNA testing is more sensitive than cytology for detection of cervical intraepithelial neoplasia grade 3 and cancer ( greater than or equal to CIN3). Adding HPV testing to cytology is recommended for women greater than or equal to 30 but long-term prospective studies of HPV testing are rare. METHODS: Beginning in 1989-1990, similar to 20,000 women in a prepaid health maintenance organization (median age = 34) were followed passively by recommended annual cytology. We tested archived cervicovaginal lavage specimens collected at enrollment, primarily by MY09-MY11 PCR-based methods, for carcinogenic HPV types. We calculated positive and negative predictive values for the entire study period, and Kaplan-Meier estimates of cumulative probability for greater than or equal to CIN3, up to 18 years of follow-up. RESULTS: We observed 47 cases of invasive cervical cancer during the study period, and 156 cases of CIN3. Predictive values and Kaplan-Meier analyses yielded the same conclusions. In women 30 and older, the reassurance against greater than or equal to CIN3 following a single negative HPV test was long-lasting (cumulative probability = 0.7% during follow-up). In this age group, a single HPV test (positive vs. negative, hazard ratio of 8.5, 95% CI = 4.8-15.1) provided greater long-term risk stratification than a single cytologic result (abnormal vs. normal, HR = 2.9, 95% CI = 1.2-6.6). The risk for greater than or equal to CIN3 was higher for HPV16 than for the average of the other carcinogenic types (hazard ratio = 2.7). CONCLUSION: and Impact: The data from this cohort study show the long-term predictive value of HPV testing, particularly in women greater than or equal to 30, and a possible role for distinguishing particularly carcinogenic types like HPV16. Cancer Epidemiol Biomarkers Prev; 20(7); 1398-409. [copy ]2011 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Schiffman, Mark AU - Glass, Andrew G AU - Wentzensen, Nicolas AU - Rush, Brenda B AU - Castle, Philip E AU - Scott, David R AU - Buckland, Julie AU - Sherman, Mark E AU - Rydzak, Greg AU - Kirk, Peter AU - Lorincz, Attila T AU - Wacholder, Sholom AU - Burk, Robert D AD - Authors' Affiliations: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 1398 EP - 1409 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States VL - 20 IS - 7 SN - 1055-9965, 1055-9965 KW - Virology & AIDS Abstracts; Risk Abstracts KW - Age KW - Invasiveness KW - Cervical cancer KW - Stratification KW - Infection KW - Neoplasia KW - Carcinogenicity KW - Human papillomavirus 16 KW - infection KW - prevention KW - Bioindicators KW - Data processing KW - biomarkers KW - Cancer KW - DNA KW - Females KW - Cervix KW - Human papillomavirus KW - R2 23060:Medical and environmental health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904484106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=A+Long-term+Prospective+Study+of+Type-Specific+Human+Papillomavirus+Infection+and+Risk+of+Cervical+Neoplasia+Among+20%2C000+Women+in+the+Portland+Kaiser+Cohort+Study&rft.au=Schiffman%2C+Mark%3BGlass%2C+Andrew+G%3BWentzensen%2C+Nicolas%3BRush%2C+Brenda+B%3BCastle%2C+Philip+E%3BScott%2C+David+R%3BBuckland%2C+Julie%3BSherman%2C+Mark+E%3BRydzak%2C+Greg%3BKirk%2C+Peter%3BLorincz%2C+Attila+T%3BWacholder%2C+Sholom%3BBurk%2C+Robert+D&rft.aulast=Schiffman&rft.aufirst=Mark&rft.date=2011-01-01&rft.volume=20&rft.issue=7&rft.spage=1398&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Invasiveness; Age; Data processing; Cervical cancer; DNA; Infection; Cervix; biomarkers; Neoplasia; Bioindicators; Carcinogenicity; prevention; infection; Females; Stratification; Cancer; Human papillomavirus 16; Human papillomavirus ER - TY - JOUR T1 - Increased Risk of Lung Cancer in Men with Tuberculosis in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study AN - 904480411; 14624118 AB - BACKGROUND: Lung cancer and tuberculosis cause significant morbidity and mortality worldwide. Tuberculosis may increase lung cancer risk through substantial and prolonged pulmonary inflammation. However, prospective data on tuberculosis and lung cancer risk are limited. METHODS: Our study included 29,133 Finnish male smokers followed prospectively in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (1985-2005). Lung cancers were identified through linkage with the Finnish Cancer Registry, and hospital-treated tuberculosis cases were ascertained from the National Hospital Discharge Register. We assessed the association between tuberculosis and lung cancer risk with proportional hazards regression models, adjusting for age and cigarette smoking. RESULTS: Forty-four lung cancer cases occurred among 273 men with tuberculosis (incidence rate = 1,786 per 100,000 person-years). Tuberculosis was associated with a two-fold elevation in lung cancer risk (HR = 1.97; 95% CI = 1.46-2.65) with significant associations observed for both incident (HR = 2.05; 95% CI = 1.42-2.96) and prevalent tuberculosis (HR = 1.82; 95% CI = 1.09-3.02). Lung cancer risk was greatest in the 2-year window after tuberculosis diagnosis (HR = 5.01; 95% CI = 2.96-8.48) but remained elevated at longer latencies (HR = 1.53; 95% CI = 1.07-2.20). Though tuberculosis was associated with an increased risk of squamous cell carcinoma (HR = 3.71), adenocarcinoma (HR = 1.71), small cell carcinoma (HR = 1.72), and lung cancer of other (HR = 1.23) and unknown histologies (HR = 1.35), only the association for squamous cell carcinoma was statistically significant. CONCLUSIONS: Tuberculosis is associated with increased lung cancer risk in male smokers. IMPACT: Our results add to the growing body of evidence implicating chronic inflammation and pulmonary scarring in the etiology of lung cancer. Cancer Epidemiol Biomarkers Prev; 20(4); 672-8. [copy ]2011 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Shiels, Meredith S AU - Albanes, Demetrius AU - Virtamo, Jarmo AU - Engels, Eric A AD - Authors' Affiliations: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 672 EP - 678 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 20 IS - 4 SN - 1055-9965, 1055-9965 KW - Health & Safety Science Abstracts; Microbiology Abstracts B: Bacteriology; Risk Abstracts KW - Adenocarcinoma KW - Age KW - Bioindicators KW - Cancer KW - Cigarette smoking KW - Cigarettes KW - Data processing KW - Etiology KW - Health risks KW - Hospitals KW - Inflammation KW - Lung cancer KW - Morbidity KW - Mortality KW - Prevention KW - Regression analysis KW - Statistical analysis KW - Tuberculosis KW - biomarkers KW - squamous cell carcinoma KW - Mycobacterium KW - H 11000:Diseases/Injuries/Trauma KW - J 02400:Human Diseases KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904480411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Increased+Risk+of+Lung+Cancer+in+Men+with+Tuberculosis+in+the+Alpha-Tocopherol%2C+Beta-Carotene+Cancer+Prevention+Study&rft.au=Shiels%2C+Meredith+S%3BAlbanes%2C+Demetrius%3BVirtamo%2C+Jarmo%3BEngels%2C+Eric+A&rft.aulast=Shiels&rft.aufirst=Meredith&rft.date=2011-01-01&rft.volume=20&rft.issue=4&rft.spage=672&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Mortality; Etiology; Age; Data processing; Statistical analysis; squamous cell carcinoma; biomarkers; Morbidity; Inflammation; Cigarette smoking; Regression analysis; Tuberculosis; Adenocarcinoma; Lung cancer; Hospitals; Bioindicators; Health risks; Prevention; Cigarettes; Cancer; Mycobacterium ER - TY - JOUR T1 - Advanced networks and computing in healthcare AN - 904480232; 14987388 AB - As computing and network capabilities continue to rise, it becomes increasingly important to understand the varied applications for using them to provide healthcare. The objective of this review is to identify key characteristics and attributes of healthcare applications involving the use of advanced computing and communication technologies, drawing upon 45 research and development projects in telemedicine and other aspects of healthcare funded by the National Library of Medicine over the past 12 years. Only projects publishing in the professional literature were included in the review. Four projects did not publish beyond their final reports. In addition, the authors drew on their first-hand experience as project officers, reviewers and monitors of the work. Major themes in the corpus of work were identified, characterizing key attributes of advanced computing and network applications in healthcare. Advanced computing and network applications are relevant to a range of healthcare settings and specialties, but they are most appropriate for solving a narrower range of problems in each. Healthcare projects undertaken primarily to explore potential have also demonstrated effectiveness and depend on the quality of network service as much as bandwidth. Many applications are enabling, making it possible to provide service or conduct research that previously was not possible or to achieve outcomes in addition to those for which projects were undertaken. Most notable are advances in imaging and visualization, collaboration and sense of presence, and mobility in communication and information-resource use. JF - Journal of the American Medical Informatics Association AU - Ackerman, Michael AU - Locatis, Craig AD - Office of High Performance Computing & Communications, National Library of Medicine/National Institutes of Health, Bethesda, Maryland, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 523 EP - 528 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Bethesda MD 20814 USA VL - 18 IS - 4 SN - 1067-5027, 1067-5027 KW - Biotechnology and Bioengineering Abstracts KW - Development projects KW - Mobility KW - Informatics KW - Reviews KW - Communication KW - imaging KW - Telemedicine KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904480232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=Normalized+names+for+clinical+drugs%3A+RxNorm+at+6+years&rft.au=Nelson%2C+Stuart+J%3BZeng%2C+Kelly%3BKilbourne%2C+John%3BPowell%2C+Tammy%3BMoore%2C+Robin&rft.aulast=Nelson&rft.aufirst=Stuart&rft.date=2011-01-01&rft.volume=18&rft.issue=4&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Development projects; Mobility; Informatics; Reviews; Communication; imaging; Telemedicine ER - TY - JOUR T1 - Employment and work schedule are related to telomere length in women AN - 904477402; 15210415 AB - OBJECTIVES: To examine the association of employment and work schedule with shorter DNA telomeres, a marker of cellular ageing and disease risk factor, and consider whether differences were related to health, behaviours and sociodemographic factors, or varied by stress levels or menopausal status. METHODS: This cross-sectional analysis of 608 women aged 35-74 in the Sister Study examined determinants of relative telomere length (rTL) measured by quantitative PCR in leucocyte DNA. Age-adjusted regression models estimated base pair (bp) rTL differences for current and lifetime schedule characteristics (ie, part-time, full-time or overtime hours; multiple jobs; irregular hours; shiftwork; work at night). Covariates included race, smoking, perceived stress, sleep, physical activity, health and menopausal status, education, marital status, live births, children under 18, measured body mass index and urinary stress hormones. RESULTS: Compared with non-employed women with moderate or substantial past work histories (n=190), those currently working full-time (n=247; median 40 h/week) had a shorter rTL, an age-adjusted difference of -329 bp (95% CI -110 to -548). Longer-duration full-time work was also associated with shorter rTL (age-adjusted difference of -472 bp, 95% CI -786 to -158 for 20+ vs 1-5 years). Findings were not explained by health and demographic covariates. However, rTL differences for working at least full-time were greater in women with higher stress and epinephrine levels. CONCLUSIONS: Current and long-term full-time work were associated with shorter rTL, with differences of similar magnitude to smoking and history of heart disease or diabetes. Longitudinal data with specific stress measures are needed to further evaluate the impact of work schedule on rTL. JF - Occupational and Environmental Medicine AU - Parks, C G AU - DeRoo, L A AU - Miller, D B AU - McCanlies, E C AU - Cawthon, R M AU - Sandler, D P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 582 EP - 589 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 68 IS - 8 SN - 1351-0711, 1351-0711 KW - Biochemistry Abstracts 2: Nucleic Acids; Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - employment KW - Physical activity KW - Aging KW - Hormones KW - working conditions KW - heart diseases KW - Demography KW - Smoking KW - Risk factors KW - Regression analysis KW - Polymerase chain reaction KW - Epinephrine KW - Races KW - Base pairs KW - Heart diseases KW - Data processing KW - Leukocytes KW - Stress KW - Children KW - Diabetes mellitus KW - Telomeres KW - Perception KW - Sleep KW - DNA KW - Body mass index KW - Phase shift KW - N 14820:DNA Metabolism & Structure KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904477402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Employment+and+work+schedule+are+related+to+telomere+length+in+women&rft.au=Parks%2C+C+G%3BDeRoo%2C+L+A%3BMiller%2C+D+B%3BMcCanlies%2C+E+C%3BCawthon%2C+R+M%3BSandler%2C+D+P&rft.aulast=Parks&rft.aufirst=C&rft.date=2011-01-01&rft.volume=68&rft.issue=8&rft.spage=582&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Data processing; Physical activity; Aging; Leukocytes; Stress; Children; Hormones; Diabetes mellitus; Demography; Telomeres; Smoking; Risk factors; Sleep; Regression analysis; Polymerase chain reaction; Body mass index; Epinephrine; Races; Phase shift; Heart diseases; Base pairs; Historical account; employment; Perception; DNA; heart diseases; working conditions ER - TY - JOUR T1 - Role of polynucleotide phosphorylase in sRNA function in Escherichia coli AN - 904476430; 14894949 AB - In Escherichia coli, many small noncoding regulatory RNAs (sRNAs) post-transcriptionally regulate gene expression by base-pairing to mRNAs in a process that is mediated by the RNA chaperone Hfq. Binding of the sRNA to the mRNA can lead to increased or decreased mRNA stability and/or translation. It is not known if proteins other than Hfq are necessary for this process. In order to identify additional genes required for the post-transcriptional regulation of gene expression by Hfq-dependent sRNAs, we developed a novel combined genetic selection and screen for mutants defective in sRNA regulation. In our combined genetic selection and screen, we isolated hfq mutants and mutants in pnp, encoding polynucleotide phosphorylase (PNPase). We show that loss-of-function mutations in pnp result in a decreased stability of several sRNAs including RyhB, SgrS, and CyaR and also decrease both the negative and positive regulation by sRNAs. The defect in stability of CyaR and in negative and positive regulation are suppressed by deletion mutations in RNase E. Altogether, our results suggest that the lack of sRNA-mediated regulation in the absence of an active form of PNPase is due to the rapid turnover of sRNA resulting from an increase in RNase E activity and/or an increase in access of other ribonucleases to sRNAs. JF - RNA AU - De Lay, Nicholas AU - Gottesman, Susan AD - Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 1172 EP - 1189 PB - Cold Spring Harbor Laboratory Press, Fulfillment & Distribution Dept. Woodbury NY 11797-2924 USA VL - 17 IS - 6 SN - 1355-8382, 1355-8382 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Gene expression KW - Translation KW - mRNA stability KW - ribonuclease E KW - Escherichia coli KW - Ribonuclease KW - polynucleotide phosphorylase KW - Chaperones KW - Post-transcription KW - Mutation KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904476430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=RNA&rft.atitle=Role+of+polynucleotide+phosphorylase+in+sRNA+function+in+Escherichia+coli&rft.au=De+Lay%2C+Nicholas%3BGottesman%2C+Susan&rft.aulast=De+Lay&rft.aufirst=Nicholas&rft.date=2011-01-01&rft.volume=17&rft.issue=6&rft.spage=1172&rft.isbn=&rft.btitle=&rft.title=RNA&rft.issn=13558382&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Gene expression; Translation; mRNA stability; ribonuclease E; Ribonuclease; Chaperones; polynucleotide phosphorylase; Post-transcription; Mutation; Escherichia coli ER - TY - JOUR T1 - The Association of Telomere Length and Cancer: a Meta-analysis AN - 904475401; 14956976 AB - BACKGROUND: Telomeres shorten with each cell division and are essential for chromosomal stability. Short telomeres in surrogate tissues (e.g., blood cells) are associated with increased cancer risk in several case-control studies, but findings are inconsistent in prospective studies. METHODS: We systematically reviewed studies published prior to August 30, 2010, on the association between telomere length (TL) in surrogate tissues and cancer. There were 27 reports on 13 cancers and/or incident cancer investigating this association. The majority, 16, were retrospective case-control studies, 11 were prospective studies. Meta-analyses were conducted to determine ORs and 95% CIs for these studies. RESULTS: Studies on bladder, esophageal, gastric, head and neck, ovarian, renal, and overall incident cancer found associations between short telomeres and these cancers. Non-Hodgkin lymphoma, breast, lung, and colorectal cancer reports were inconsistent. Single studies on endometrial, prostate, and skin cancers were null. In a random-effects meta-analysis, short TL was significantly associated with cancer in retrospective studies (pooled OR for the shortest TL quartile compared with the longest: 2.9, 95% CI: 1.75-4.8, P < 0.0001). The pooled OR for prospective studies was 1.16 (95% CI: 0.87-1.54, P = 0.32). All studies combined yielded a pooled OR of 1.96 (95% CI: 1.37-2.81, P = 0.0001) for the association of short TL and cancer. CONCLUSION: and Impact: There is suggestive evidence that short surrogate tissue TL is associated with cancer; the strongest evidence exists for bladder, esophageal, gastric, and renal cancers. Additional prospective studies with consistent methodology are needed to confirm this hypothesis. Cancer Epidemiol Biomarkers Prev; 20(6); 1238-50. [copy ]2011 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Wentzensen, Ingrid M AU - Mirabello, Lisa AU - Pfeiffer, Ruth M AU - Savage, Sharon A AD - Authors' Affiliations: Clinical Genetics Branch and Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 1238 EP - 1250 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 20 IS - 6 SN - 1055-9965, 1055-9965 KW - Biochemistry Abstracts 2: Nucleic Acids; Health & Safety Science Abstracts; Risk Abstracts KW - Bioindicators KW - Telomeres KW - Cancer KW - H 11000:Diseases/Injuries/Trauma KW - N 14820:DNA Metabolism & Structure KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904475401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=The+Association+of+Telomere+Length+and+Cancer%3A+a+Meta-analysis&rft.au=Wentzensen%2C+Ingrid+M%3BMirabello%2C+Lisa%3BPfeiffer%2C+Ruth+M%3BSavage%2C+Sharon+A&rft.aulast=Wentzensen&rft.aufirst=Ingrid&rft.date=2011-01-01&rft.volume=18&rft.issue=&rft.spage=i161&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-04-03 N1 - SubjectsTermNotLitGenreText - Telomeres; Cancer ER - TY - JOUR T1 - Obesity and Thyroid Cancer Risk among U.S. Men and Women: A Pooled Analysis of Five Prospective Studies AN - 904474946; 14451148 AB - BACKGROUND: Thyroid cancer incidence has risen dramatically in the United States since the early 1980s. Although the prevalence of obesity has doubled during this time period, the relationship between obesity and thyroid cancer is uncertain. METHODS: We examined the association between body mass index (BMI) and thyroid cancer risk in a pooled analysis of five prospective U.S. studies, including 413,979 women and 434,953 men. Proportional hazards models with attained age as the time metric were adjusted for education, race, marital status, smoking, alcohol intake, and (where appropriate) cohort and sex. RESULTS: Over follow-up (mean = 10.3 years), 768 women and 388 men were diagnosed with thyroid cancer. The risk of thyroid cancer was greater with increasing BMI [per 5 kg/m2: HR in women, 1.16 (95% CI, 1.08-1.24); HR in men, 1.21 (95% CI, 0.97-1.49)]. There was no significant heterogeneity between studies (both P > 0.05). For women and men combined, the HRs for overweight (25.0-29.9 kg/m2) and obesity ( greater than or equal to 30 kg/m2) compared with normal-weight (18.5-24.9 kg/m2) were 1.20 (95% CI, 1.04-1.38) and 1.53 (95% CI, 1.31-1.79), respectively. We found no significant effect modification by other factors, and the results did not differ significantly by histologic type. A significant positive association for BMI in young adulthood (ages 18-20) with thyroid cancer risk was also observed [per 5-kg/m2 increase: HR, 1.18 (95% CI, 1.03-1.35)]. CONCLUSION: BMI was positively associated with thyroid cancer risk in both men and women. IMPACT: Our study provides strong evidence that obesity is an independent risk factor for thyroid cancer. Cancer Epidemiol Biomarkers Prev; 20(3); 464-72. [copy ]2011 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Kitahara, Cari M AU - Platz, Elizabeth A AU - Freeman, Laura EBeane AU - Hsing, Ann W AU - Linet, Martha S AU - Park, Yikyung AU - Schairer, Catherine AU - Schatzkin, Arthur AU - Shikany, James M AU - Berrington de Gonzalez, Amy AD - Authors' Affiliations: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville Y1 - 2011 PY - 2011 DA - 2011 SP - 464 EP - 472 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 20 IS - 3 SN - 1055-9965, 1055-9965 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Bioindicators KW - Alcohol KW - USA KW - Age KW - Education KW - Risk factors KW - Thyroid KW - obesity KW - males KW - Cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904474946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Obesity+and+Thyroid+Cancer+Risk+among+U.S.+Men+and+Women%3A+A+Pooled+Analysis+of+Five+Prospective+Studies&rft.au=Kitahara%2C+Cari+M%3BPlatz%2C+Elizabeth+A%3BFreeman%2C+Laura+EBeane%3BHsing%2C+Ann+W%3BLinet%2C+Martha+S%3BPark%2C+Yikyung%3BSchairer%2C+Catherine%3BSchatzkin%2C+Arthur%3BShikany%2C+James+M%3BBerrington+de+Gonzalez%2C+Amy&rft.aulast=Kitahara&rft.aufirst=Cari&rft.date=2011-01-01&rft.volume=20&rft.issue=3&rft.spage=464&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Bioindicators; Alcohol; Education; Age; Risk factors; obesity; Thyroid; males; Cancer; USA ER - TY - JOUR T1 - Normalized names for clinical drugs: RxNorm at 6 years AN - 904474611; 14987400 AB - OBJECTIVE: In the 6 years since the National Library of Medicine began monthly releases of RxNorm, RxNorm has become a central resource for communicating about clinical drugs and supporting interoperation between drug vocabularies. MATERIALS AND METHODS: Built on the idea of a normalized name for a medication at a given level of abstraction, RxNorm provides a set of names and relationships based on 11 different external source vocabularies. The standard model enables decision support to take place for a variety of uses at the appropriate level of abstraction. With the incorporation of National Drug File Reference Terminology (NDF-RT) from the Veterans Administration, even more sophisticated decision support has become possible. DISCUSSION: While related products such as RxTerms, RxNav, MyMedicationList, and MyRxPad have been recognized as helpful for various uses, tasks such as identifying exactly what is and is not on the market remain a challenge. JF - Journal of the American Medical Informatics Association AU - Nelson, Stuart J AU - Zeng, Kelly AU - Kilbourne, John AU - Powell, Tammy AU - Moore, Robin AD - U.S. National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 441 EP - 448 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Bethesda MD 20814 USA VL - 18 IS - 4 SN - 1067-5027, 1067-5027 KW - Biotechnology and Bioengineering Abstracts KW - Informatics KW - Drugs KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904474611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=Normalized+names+for+clinical+drugs%3A+RxNorm+at+6+years&rft.au=Nelson%2C+Stuart+J%3BZeng%2C+Kelly%3BKilbourne%2C+John%3BPowell%2C+Tammy%3BMoore%2C+Robin&rft.aulast=Nelson&rft.aufirst=Stuart&rft.date=2011-01-01&rft.volume=18&rft.issue=4&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Informatics; Drugs; Models ER - TY - JOUR T1 - Genetic Polymorphisms in Inflammation Pathway Genes and Prostate Cancer Risk AN - 904473903; 14811575 AB - BACKGROUND: Chronic inflammation is an important mechanism for the development and progression of prostate cancer (PC). To better understand the potential relationship between genes in the inflammation pathway and PC risk, we evaluated variants in 16 candidate genes. METHODS: A total of 143 tagging and amino acid altering single nucleotide polymorphisms (SNPs) were genotyped in Caucasian and African American men participating in one of two population-based, case-control studies (n = 1,458 cases and 1,351 controls). The relative risk of PC was estimated using logistic and polytomous regression models. RESULTS: Ten SNPs in seven genes (CXCL12, IL4, IL6, IL6ST, PTGS2, STAT3, and TNF) were nominally associated (P < 0.05) with risk of PC in Caucasians. The most significant effect on risk was seen with rs11574783 in the interleukin 6 signal transducer (IL6ST) gene (OR = 0.08, 95% CI: 0.01-0.63). Cumulatively, four SNPs in genes interleukin 4 (IL4), IL6ST, PTGS2, and signal transducer and activator of transcription 3 (STAT3) conferred a three-fold elevation in PC risk among men carrying the maximum number of high-risk alleles (OR = 2.97, 95% CI: 1.41-6.25, Ptrend = 0.0003). Risk estimates for seven SNPs varied significantly according to disease aggressiveness (Phomogeneity < 0.05), with SNPs in AKT1, PIK3R1, and STAT3 independently associated with more aggressive PC; OR = 5.1 (95% CI: 2.29-11.40, Ptrend = 3.8 x 10-5) for carriers of all high-risk genotypes. CONCLUSIONS: These results suggest that variants in genes within the inflammation pathway may play a role in the development of PC, however, further studies are needed to replicate our findings. IMPACT: These results underline the potential importance of the inflammation pathway in PC development and progression. Cancer Epidemiol Biomarkers Prev; 20(5); 923-33. [copy ]2011 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Kwon, Erika M AU - Salinas, Claudia A AU - Kolb, Suzanne AU - Fu, Rong AU - Feng, Ziding AU - Stanford, Janet L AU - Ostrander, Elaine A AD - Authors' Affiliations: National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Bethesda Y1 - 2011 PY - 2011 DA - 2011 SP - 923 EP - 933 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 20 IS - 5 SN - 1055-9965, 1055-9965 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Bioindicators KW - Prevention KW - Amino acids KW - prevention KW - transducers KW - Genotypes KW - prostate cancer KW - aggressive behavior KW - Cancer KW - Ethnic groups KW - H 11000:Diseases/Injuries/Trauma KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904473903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Genetic+Polymorphisms+in+Inflammation+Pathway+Genes+and+Prostate+Cancer+Risk&rft.au=Kwon%2C+Erika+M%3BSalinas%2C+Claudia+A%3BKolb%2C+Suzanne%3BFu%2C+Rong%3BFeng%2C+Ziding%3BStanford%2C+Janet+L%3BOstrander%2C+Elaine+A&rft.aulast=Kwon&rft.aufirst=Erika&rft.date=2011-01-01&rft.volume=20&rft.issue=5&rft.spage=923&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Bioindicators; Prevention; Amino acids; prevention; transducers; Genotypes; aggressive behavior; prostate cancer; Ethnic groups; Cancer ER - TY - JOUR T1 - Reproductive and Hormonal Factors and Lung Cancer Risk in the NIH-AARP Diet and Health Study Cohort AN - 904473899; 14811573 AB - BACKGROUND: Lung cancer exhibits unique patterns among women including high adenocarcinoma rates among nonsmokers. Inconsistent findings about hormonal factors on risk may reflect incomplete control for confounding, misclassification of exposures, or insufficient attention to variation by histology. METHODS: Among 185,017 women, ages 50 to 71 years, recruited during 1995 and 1996 for the NIH-AARP (American Association of Retired Persons) Diet and Health Study, we identified 3,512 incident lung cancers (including 276 in never smokers) in follow-up through December 2006. Multivariable Cox proportional hazards models estimated relative risks (RR) and 95% CIs for self-reported hormonally related risk factors. RESULTS: After adjustment for smoking and other confounders, subjects with late menarche were at reduced risk, with the association specific for adenocarcinomas (RR = 0.72 for menarche 15+ vs. <11, Ptrend < 0.01). Subjects with early ages at ovarian cessation (either from natural menopause or bilateral oophorectomy) were at an increased risk for adenocarcinomas and squamous cell tumors, but the associations were strongest for smokers, suggesting either residual confounding or an enhanced effect of menopausally related factors among subjects with decreased endogenous estrogens. In contrast, we saw no relationships of risk with either parity, age at first birth, or exogenous hormone use. CONCLUSIONS: Elevated levels of hormones may adversely affect lung function early in life while assisting with cellular and immunologic responses later in life. Additional attention toward the role of hormonal factors may further our understanding of lung carcinogenesis. IMPACT: Our findings provide some support for a role of hormonal factors in the etiology of lung cancer, although the mechanisms appear complicated. Cancer Epidemiol Biomarkers Prev; 20(5); 900-11. [copy ]2011 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Brinton, Louise A AU - Gierach, Gretchen L AU - Andaya, Abegail AU - Park, Yikyung AU - Schatzkin, Arthur AU - Hollenbeck, Albert R AU - Spitz, Margaret R AD - Authors' Affiliations: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 900 EP - 911 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 20 IS - 5 SN - 1055-9965, 1055-9965 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Bioindicators KW - Cancer KW - Carcinogenesis KW - Diets KW - Estrogens KW - Hormones KW - Lung cancer KW - Respiratory function KW - estrogens KW - prevention KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904473899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Reproductive+and+Hormonal+Factors+and+Lung+Cancer+Risk+in+the+NIH-AARP+Diet+and+Health+Study+Cohort&rft.au=Brinton%2C+Louise+A%3BGierach%2C+Gretchen+L%3BAndaya%2C+Abegail%3BPark%2C+Yikyung%3BSchatzkin%2C+Arthur%3BHollenbeck%2C+Albert+R%3BSpitz%2C+Margaret+R&rft.aulast=Brinton&rft.aufirst=Louise&rft.date=2011-01-01&rft.volume=20&rft.issue=5&rft.spage=900&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Bioindicators; Diets; Estrogens; Age; Carcinogenesis; prevention; Respiratory function; Hormones; Cancer; estrogens; Lung cancer ER - TY - JOUR T1 - Critical Analysis of the Ultrasonographic Criteria for Diagnosing Lymph Node Metastasis in Patients With Cutaneous Melanoma: A Systematic Review AN - 904473600; 14625390 AB - The purpose of this systematic review of the literature was to evaluate the use of ultrasonography (US) in the assessment of lymph node metastasis in patients with cutaneous melanoma. A multimodal strategy was used, which was mainly based on a PubMed database search. Among the 201 cumulative articles collected (years 1989-2009), 31 were found to match all of the inclusion criteria and to provide a description of the use of US scanning in lymph node melanoma metastasis. Data extracted included the author's name and country, journal and year of publication, prospective or retrospective nature of the study, single-center or multicenter nature of the study, period when US studies were performed, US transducers used, gray scale and color Doppler criteria used for diagnosis, and data on US accuracy. The diagnostic criteria used in the 31 selected articles were critically reviewed, illustrating to the reader the discrepancies and unclear aspects identified. On the basis of this review, the need to establish definitive, clearly defined, and univocal diagnostic criteria to be applied in daily clinical practice as well as to be used in articles to be published is emphasized. JF - Journal of Ultrasound in Medicine AU - Catalano, Orlando AD - First Department of Radiology, National Cancer Institute Fondazione G Y1 - 2011 PY - 2011 DA - 2011 SP - 547 EP - 560 PB - The American Institute of Ultrasound in Medicine VL - 30 IS - 4 SN - 0278-4297, 0278-4297 KW - Biotechnology and Bioengineering Abstracts KW - Metastases KW - Databases KW - Data processing KW - Scanning KW - Reviews KW - Ultrasonography KW - Ultrasound KW - Lymph nodes KW - Melanoma KW - Color KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904473600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Ultrasound+in+Medicine&rft.atitle=Critical+Analysis+of+the+Ultrasonographic+Criteria+for+Diagnosing+Lymph+Node+Metastasis+in+Patients+With+Cutaneous+Melanoma%3A+A+Systematic+Review&rft.au=Catalano%2C+Orlando&rft.aulast=Catalano&rft.aufirst=Orlando&rft.date=2011-01-01&rft.volume=30&rft.issue=4&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Journal+of+Ultrasound+in+Medicine&rft.issn=02784297&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Metastases; Databases; Data processing; Scanning; Reviews; Ultrasound; Ultrasonography; Lymph nodes; Color; Melanoma ER - TY - JOUR T1 - Prospective Study of Self-Reported Diabetes and Risk of Upper Gastrointestinal Cancers AN - 904471516; 14811547 AB - BACKGROUND: Although gastric noncardia adenocarcinoma (GNCA) incidence rates in the United States have decreased, the rates of gastric cardia adenocarcinoma (GCA) and esophageal adenocarcinoma (EADC) have increased. Obesity increases the risks of GCA and EADC, and the associations may be partially mediated by insulin resistance. A few case-control studies have shown an association between diabetes and an increased risk of EADC. METHODS: We prospectively examined the association between diabetes and upper gastrointestinal (UGI) cancers in a cohort of 469,448 people in the United States, ages 50 to 71 at baseline. Cox proportional hazards regression was used to estimate the HR and 95% CI for diabetes and UGI cancers, controlling for multiple potential confounders, including body mass index (BMI). RESULTS: We observed no association of self-reported diabetes with risk of EADC, HR (95% CI) = 0.98 (0.73-1.31), esophageal squamous cell carcinoma (ESCC), HR (95% CI) = 1.02 (0.60-1.74), or GNCA, HR (95% CI) = 0.98 (0.70-1.37). However, diabetes was significantly associated with an increased risk of GCA, HR (95% CI) = 1.89 (1.43-2.50). The significant association between diabetes and risk of GCA remained after adjustment for BMI, HR (95% CI) = 1.70 (1.28-2.26) and did not differ by BMI strata (Pinteraction = 0.83). The significant association was unchanged when restricting to only overweight subjects (BMI 25 to less than or equal to 30), HR (95% CI) = 1.83 (1.18-2.85). CONCLUSIONS: We found a significant association between self-reported diabetes and increased risk of GCA. IMPACT: Our results suggest that the metabolic and hormonal changes related to diabetes may play a role in the etiology of GCA independently from BMI. Cancer Epidemiol Biomarkers Prev; 20(5); 954-61. [copy ]2011 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Lin, Shih-Wen AU - Freedman, Neal D AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Abnet, Christian C AD - Authors' Affiliations: Cancer Prevention Fellowship Program, and Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 954 EP - 961 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 20 IS - 5 SN - 1055-9965, 1055-9965 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Bioindicators KW - Age KW - Etiology KW - insulin KW - obesity KW - Cancer KW - USA KW - diabetes mellitus KW - body mass KW - prevention KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904471516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Prospective+Study+of+Self-Reported+Diabetes+and+Risk+of+Upper+Gastrointestinal+Cancers&rft.au=Lin%2C+Shih-Wen%3BFreedman%2C+Neal+D%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur%3BAbnet%2C+Christian+C&rft.aulast=Lin&rft.aufirst=Shih-Wen&rft.date=2011-01-01&rft.volume=20&rft.issue=5&rft.spage=954&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Bioindicators; Etiology; Age; diabetes mellitus; body mass; insulin; obesity; prevention; Cancer; USA ER - TY - JOUR T1 - Prokineticin Receptor 1 Antagonist PC-10 as a Biomarker for Imaging Inflammatory Pain AN - 904471353; 14592720 AB - Prokineticin receptor 1 (PKR1) and its ligand Bv8 were shown to be expressed in inflammation-induced pain and by tumor-supporting fibroblasts. Blocking this receptor might prove useful for reducing pain and for cancer therapy. However, there is no method to quantify the levels of these receptors in vivo. METHODS: A nonpeptidic PKR1 antagonist, N-{2-[5-(4-fluoro-benzyl)-1-(4-methoxy-benzyl)-4,6-dioxo-1,4,5,6-t e trahydro-[1,3,5]triazin-2-ylamino]-ethyl}-guanidine, which contains a free guanidine group, was labeled with 18F by reacting the guanidine function with N-succinimidyl-4-18F-fluorobenzoate to give the guanidinyl amide N-(4-18F-fluoro-benzoyl)-N'-{2-[5-(4-fluoro-benzyl)-1-(4-methoxy-b e nzyl)-4,6-dioxo-1,4,5,6-tetrahydro-[1,3,5]triazin-2-ylamino]-ethyl } - guanidine (18F-PC-10). Inflammation was induced in C57BL/6 mice by subcutaneous injection of complete Freund adjuvant in the paw. The mice were imaged with 18F-PC-10, 18F-FDG, and 64Cu-pyruvaldehyde bis(4-methyl-3-thiosemicarbazone) (64Cu-PTSM) at 24 h after complete Freund adjuvant injection using a small-animal PET device. RESULTS: 18F-PC-10 was synthesized with a radiochemical yield of 16% plus or minus 3% (decay-corrected). 18F-PC-10 accumulated specifically in the inflamed paw 4- to 5-fold more than in the control paw. Compared with 18F-PC-10, 18F-FDG and 64Cu-PTSM displayed higher accumulation in the inflamed paw but also had higher accumulation in the control paw, demonstrating a reduced signal-to-background ratio. 18F-PC-10 also accumulated in PKR1-expressing organs, such as the salivary gland and gastrointestinal tract. CONCLUSION: 18F-PC-10 can be used to image PKR1, a biomarker of the inflammation process. However, the high uptake of 18F-PC-10 in the gastrointestinal tract, due to specific uptake and the metabolic processing of this highly lipophilic molecule, would restrict its utility. JF - Journal of Nuclear Medicine AU - Jacobson, Orit AU - Weiss, Ido D AU - Niu, Gang AU - Balboni, Gianfranco AU - Congiu, Cenzo AU - Onnis, Valentina AU - Kiesewetter, Dale O AU - Lattanzi, Roberta AU - Salvadori, Severo AU - Chen, Xiaoyuan AD - Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 600 EP - 607 PB - Society of Nuclear Medicine VL - 52 IS - 4 SN - 0161-5505, 0161-5505 KW - Biotechnology and Bioengineering Abstracts KW - Guanidine KW - Pain KW - Adjuvants KW - Salivary gland KW - biomarkers KW - Cancer KW - Lipophilic KW - Fibroblasts KW - Inflammation KW - Positron emission tomography KW - Nuclear medicine KW - Gastrointestinal tract KW - amides KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904471353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nuclear+Medicine&rft.atitle=Prokineticin+Receptor+1+Antagonist+PC-10+as+a+Biomarker+for+Imaging+Inflammatory+Pain&rft.au=Jacobson%2C+Orit%3BWeiss%2C+Ido+D%3BNiu%2C+Gang%3BBalboni%2C+Gianfranco%3BCongiu%2C+Cenzo%3BOnnis%2C+Valentina%3BKiesewetter%2C+Dale+O%3BLattanzi%2C+Roberta%3BSalvadori%2C+Severo%3BChen%2C+Xiaoyuan&rft.aulast=Jacobson&rft.aufirst=Orit&rft.date=2011-01-01&rft.volume=52&rft.issue=4&rft.spage=600&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Pain; Guanidine; Adjuvants; Salivary gland; biomarkers; Lipophilic; Cancer; Inflammation; Fibroblasts; Positron emission tomography; Nuclear medicine; Gastrointestinal tract; amides ER - TY - JOUR T1 - Urinary Biomarkers of Meat Consumption AN - 904471210; 14956992 AB - BACKGROUND: Meat intake has been positively associated with incidence and mortality of chronic diseases, including diabetes, heart disease, and several different cancers, in observational studies by using self-report methods of dietary assessment; however, these dietary assessment methods are subject to measurement error. One method to circumvent such errors is the use of biomarkers of dietary intake, but currently there are no accepted biomarkers for meat intake. METHODS: We investigated four analytes (creatinine, taurine, 1-methylhistidine, and 3-methylhistidine) specifically found in meat and excreted in urine. Twenty-four-hour urine samples were collected from 17 individuals on controlled diets containing varying levels of meat: vegetarian (0 g/d), low red meat (60 g/d), medium red meat (120 g/d), and high red meat (420 g/d), as part of two randomized crossover feeding studies. RESULTS: When compared with the low red meat diet or the vegetarian diet, the urinary levels of all four analytes were significantly higher in urine samples collected after 15 days of a high red meat diet (P < 0.0001). Only urinary 1-methylhistidine and 3-methylhistidine were statistically significantly different for every diet type, increasing as the amount of meat in the diet increased (P < 0.01 for 1-methylhistidine and P < 0.05 for 3-methylhistidine). Furthermore, urinary excretion of 1-methylhistidine and 3-methylhistidine elevated with increasing meat intake in every individual. CONCLUSION: Urinary 1-methylhistidine and 3-methylhistidine may be good biomarkers of meat intake. IMPACT: To determine the public health impact of red meat on cancer risk, biomarkers are crucial to estimate true intake; these potential biomarkers should be further investigated in free-living populations. Cancer Epidemiol Biomarkers Prev; 20(6); 1107-11. [copy ]2011 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Cross, Amanda J AU - Major, Jacqueline M AU - Sinha, Rashmi AD - Authors' Affiliations: Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 1107 EP - 1111 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 20 IS - 6 SN - 1055-9965, 1055-9965 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Bioindicators KW - Cancer KW - Diets KW - Excretion KW - Feeding KW - Meat KW - Mortality KW - Public health KW - Urine KW - heart diseases KW - meat KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904471210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Urinary+Biomarkers+of+Meat+Consumption&rft.au=Cross%2C+Amanda+J%3BMajor%2C+Jacqueline+M%3BSinha%2C+Rashmi&rft.aulast=Cross&rft.aufirst=Amanda&rft.date=2011-01-01&rft.volume=20&rft.issue=6&rft.spage=1107&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Meat; Diets; Bioindicators; Feeding; Mortality; Urine; meat; Excretion; heart diseases; Cancer; Public health ER - TY - JOUR T1 - Dipentyl Phthalate Dosing during Sexual Differentiation Disrupts Fetal Testis Function and Postnatal Development of the Male Sprague-Dawley Rat with Greater Relative Potency than Other Phthalates AN - 904470153; 14406843 AB - Phthalate esters (PEs) constitute a large class of plasticizer compounds that are widely used for many consumer product applications. Ten or more members of the PE class of compounds are known to induce male fetal endocrine toxicity and postnatal reproductive malformations by disrupting androgen production during the sexual differentiation period of development. An early study conducted in the rat pubertal model suggested that dipentyl phthalate (DPeP) may be a more potent testicular toxicant than some more extensively studied phthalates. Regulatory agencies require dose-response and potency data to facilitate risk assessment; however, very little data are currently available for DPeP. The goal of this study was to establish a more comprehensive data set for DPeP, focusing on dose-response and potency information for fetal and postnatal male reproductive endpoints. We dosed pregnant rats on gestational day (GD) 17 or GD 14-18 and subsequently evaluated fetal testicular testosterone (T) production on GD 17.5 and GD 18, respectively. We also dosed pregnant rats on GD 8-18 and evaluated early postnatal endpoints in male offspring. Comparison of these data to data previously obtained under similar conditions for di (2-ethylhexyl) phthalate indicates that DPeP is approximately eightfold more potent in reducing fetal T production and two- to threefold more potent in inducing development of early postnatal male reproductive malformations. Additionally, fetal testicular T production was more sensitive to inhibitory effects of DPeP exposure than was gene expression of target genes involved in male reproductive development, supporting the use of this endpoint as a critical effect in the risk assessment process. JF - Toxicological Sciences AU - Hannas, Bethany R AU - Furr, Johnathan AU - Lambright, Christy S AU - Wilson, Vickie S AU - Foster, Paul MD AU - Gray, LEarl AD - National Research Council Fellowship Program. Reproductive Toxicology Branch, Toxicology Assessment Division, National Health and Environmental Effects Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711. National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709 Y1 - 2011 PY - 2011 DA - 2011 SP - 184 EP - 193 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 120 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Androgens KW - Fetuses KW - X:24350 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904470153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=The+contribution+of+chemical+exchange+to+MRI+frequency+shifts+in+brain+tissue&rft.au=Shmueli%2C+Karin%3BDodd%2C+Stephen+J%3BLi%2C+Tie-Qiang%3BDuyn%2C+Jeff+H&rft.aulast=Shmueli&rft.aufirst=Karin&rft.date=2011-01-01&rft.volume=65&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22604 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Fetuses ER - TY - JOUR T1 - Impact of pesticide exposure misclassification on estimates of relative risks in the Agricultural Health Study AN - 904469232; 14957517 AB - BACKGROUND: The Agricultural Health Study (AHS) is a prospective study of licensed pesticide applicators and their spouses in Iowa and North Carolina. We evaluate the impact of occupational pesticide exposure misclassification on relative risks using data from the cohort and the AHS Pesticide Exposure Study (AHS/PES). METHODS: We assessed the impact of exposure misclassification on relative risks using the range of correlation coefficients observed between measured post-application urinary levels of 2,4-dichlorophenoxyacetic acid (2,4-D) and a chlorpyrifos metabolite and exposure estimates based on an algorithm from 83 AHS pesticide applications. RESULTS: Correlations between urinary levels of 2,4-D and a chlorpyrifos metabolite and algorithm estimated intensity scores were about 0.4 for 2,4-D (n=64), 0.8 for liquid chlorpyrifos (n=4) and 0.6 for granular chlorpyrifos (n=12). Correlations of urinary levels with kilograms of active ingredient used, duration of application, or number of acres treated were lower and ranged from -0.36 to 0.19. These findings indicate that a priori expert-derived algorithm scores were more closely related to measured urinary levels than individual exposure determinants evaluated here. Estimates of potential bias in relative risks based on the correlations from the AHS/PES indicate that non-differential misclassification of exposure using the algorithm would bias estimates towards the null, but less than that from individual exposure determinants. CONCLUSIONS: Although correlations between algorithm scores and urinary levels were quite good (ie, correlations between 0.4 and 0.8), exposure misclassification would still bias relative risk estimates in the AHS towards the null and diminish study power. JF - Occupational and Environmental Medicine AU - Blair, Aaron AU - Thomas, Kent AU - Coble, Joseph AU - Sandler, Dale P AU - Hines, Cynthia J AU - Lynch, Charles F AU - Knott, Charles AU - Purdue, Mark P AU - Zahm, Shelia Hoar AU - Alavanja, Michael C R AU - Dosemeci, Mustafa AU - Kamel, Freya AU - Hoppin, Jane A AU - Freeman, Laura Beane AU - Lubin, Jay H AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 537 EP - 541 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR UK VL - 68 IS - 7 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - 2,4-D KW - USA, North Carolina KW - Data processing KW - Algorithms KW - Metabolites KW - Pesticide applications KW - Chlorpyrifos KW - USA, Iowa KW - Urine KW - Pesticides KW - 2,4-Dichlorophenoxyacetic acid KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904469232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Impact+of+pesticide+exposure+misclassification+on+estimates+of+relative+risks+in+the+Agricultural+Health+Study&rft.au=Blair%2C+Aaron%3BThomas%2C+Kent%3BCoble%2C+Joseph%3BSandler%2C+Dale+P%3BHines%2C+Cynthia+J%3BLynch%2C+Charles+F%3BKnott%2C+Charles%3BPurdue%2C+Mark+P%3BZahm%2C+Shelia+Hoar%3BAlavanja%2C+Michael+C+R%3BDosemeci%2C+Mustafa%3BKamel%2C+Freya%3BHoppin%2C+Jane+A%3BFreeman%2C+Laura+Beane%3BLubin%2C+Jay+H&rft.aulast=Blair&rft.aufirst=Aaron&rft.date=2011-01-01&rft.volume=68&rft.issue=7&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - 2,4-D; Chlorpyrifos; Risk assessment; Data processing; Pesticides; Algorithms; Metabolites; Occupational exposure; Pesticide applications; Urine; 2,4-Dichlorophenoxyacetic acid; USA, North Carolina; USA, Iowa ER - TY - JOUR T1 - Arsenic, Stem Cells, and the Developmental Basis of Adult Cancer AN - 904468872; 14406862 AB - That chemical insults or nutritive changes during in utero and/or postnatal life can emerge as diseases much later in life are now being accepted as a recurring phenomenon. In this regard, inorganic arsenic is a multisite human carcinogen found at high levels in the drinking water of millions of people, although it has been difficult until recently to produce tumors in rodents with this metalloid. A mouse transplacental model has been developed where maternal exposure to inorganic arsenic either acts as a complete carcinogen or enhances carcinogenic response to other agents given subsequently in the offspring, producing tumors during adulthood. Similarly, human data now have emerged showing that arsenic exposure during the in utero period and/or in early life is associated with cancer in adulthood. The mouse arsenic transplacental model produces tumors or enhances response to other agents in multiple strains and tissues, including sites concordant with human targets of arsenic carcinogenesis. It is now believed that cancer often is a stem cell (SC)-based disease, and there is no reason to think cancer induced by developmental chemical exposure is any different. Indeed, arsenic impacts human SC population dynamics in vitro by blocking exit into differentiation pathways and whereby creating more key targets for transformation. In fact, during in vitro malignant transformation, arsenic causes a remarkable survival selection of SCs, creating a marked overabundance of cancer SCs (CSCs) compared with other carcinogens once a cancer phenotype is obtained. In addition, skin cancers produced following in utero arsenic exposure in mice are highly enriched in CSCs. Thus, arsenic impacts key, long-lived SC populations as critical targets to cause or facilitate later oncogenic events in adulthood as a possible mechanism of developmental basis of adult disease. JF - Toxicological Sciences AU - Tokar, Erik J AU - Qu, Wei AU - Waalkes, Michael P AD - National Toxicology Program Laboratories, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina Y1 - 2011 PY - 2011 DA - 2011 SP - S192 EP - S203 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 120 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Animal models KW - Arsenic KW - X:24360 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904468872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Arsenic%2C+Stem+Cells%2C+and+the+Developmental+Basis+of+Adult+Cancer&rft.au=Tokar%2C+Erik+J%3BQu%2C+Wei%3BWaalkes%2C+Michael+P&rft.aulast=Tokar&rft.aufirst=Erik&rft.date=2011-01-01&rft.volume=120&rft.issue=&rft.spage=S192&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Arsenic ER - TY - JOUR T1 - Occupation and bladder cancer in a population-based case-control study in Northern New England AN - 904468333; 14516847 AB - OBJECTIVES: We used data from a large, population-based case-control study in Maine, New Hampshire, and Vermont to examine relationships between occupation, industry and bladder cancer risk. METHODS: Lifetime occupational histories were obtained by personal interview from 1158 patients newly diagnosed with urothelial carcinoma of the bladder in 2001-2004, and from 1402 population controls. Unconditional logistic regression was used to calculate ORs and 95% CIs, adjusted for demographic factors, smoking and employment in other high-risk occupations. RESULTS: Male precision metalworkers and metalworking/plasticworking machine operators had significantly elevated risks and significant trends in risk with duration of employment (precision metalworkers: OR 2.2, 95% CI 1.4 to 3.4, ptrend=0.0065; metalworking/plasticworking machine operators: OR 1.6, 95% CI 1.01 to 2.6, ptrend=0.047). Other occupations/industries for which risk increased significantly with duration of employment included: for men, textile machine operators, mechanics/repairers, automobile mechanics, plumbers, computer systems analysts, information clerks, and landscape industry workers; for women, service occupations, health services, cleaning and building services, management-related occupations, electronic components manufacturing and transportation equipment manufacturing. Men reporting use of metalworking fluids (MWF) had a significantly elevated bladder cancer risk (OR 1.7, 95% CI 1.1 to 2.5). CONCLUSIONS: Our findings support the hypothesis that some component(s) of MWF may be carcinogenic to the bladder. Our results also corroborate many other previously reported associations between bladder cancer risk and various occupations. More detailed analyses using information from the study's job-specific questionnaires may help to identify MWF components that may be carcinogenic, and other bladder carcinogens associated with a variety of occupations. JF - Occupational and Environmental Medicine AU - Colt, Joanne S AU - Karagas, Margaret R AU - Schwenn, Molly AU - Baris, Dalsu AU - Johnson, Alison AU - Stewart, Patricia AU - Verrill, Castine AU - Moore, Lee E AU - Lubin, Jay AU - Ward, Mary H AU - Samanic, Claudine AU - Rothman, Nathaniel AU - Cantor, Kenneth P AU - Beane Freeman, Laura E AU - Schned, Alan AU - Cherala, Sai AU - Silverman, Debra T AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 239 EP - 249 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR UK VL - 68 IS - 4 SN - 1351-0711, 1351-0711 KW - Risk Abstracts; Health & Safety Science Abstracts KW - demography KW - Historical account KW - employment KW - Landscape KW - Carcinogens KW - urinary bladder KW - Transportation KW - USA, New England KW - Carcinogenicity KW - USA, Maine KW - USA, New Hampshire KW - USA, Vermont KW - population control KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904468333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Occupation+and+bladder+cancer+in+a+population-based+case-control+study+in+Northern+New+England&rft.au=Colt%2C+Joanne+S%3BKaragas%2C+Margaret+R%3BSchwenn%2C+Molly%3BBaris%2C+Dalsu%3BJohnson%2C+Alison%3BStewart%2C+Patricia%3BVerrill%2C+Castine%3BMoore%2C+Lee+E%3BLubin%2C+Jay%3BWard%2C+Mary+H%3BSamanic%2C+Claudine%3BRothman%2C+Nathaniel%3BCantor%2C+Kenneth+P%3BBeane+Freeman%2C+Laura+E%3BSchned%2C+Alan%3BCherala%2C+Sai%3BSilverman%2C+Debra+T&rft.aulast=Colt&rft.aufirst=Joanne&rft.date=2011-01-01&rft.volume=68&rft.issue=4&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Methods+in+Cell+Biology&rft.issn=0091679X&rft_id=info:doi/10.1016%2FB978-0-12-381320-6.00006-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - demography; Historical account; urinary bladder; Transportation; employment; Carcinogenicity; Landscape; Carcinogens; population control; USA, New England; USA, Maine; USA, New Hampshire; USA, Vermont ER - TY - JOUR T1 - Severe Mood Dysregulation, Irritability, and the Diagnostic Boundaries of Bipolar Disorder in Youths AN - 904468043; 14340030 AB - In recent years, increasing numbers of children have been diagnosed with bipolar disorder. In some cases, children with unstable mood clearly meet current diagnostic criteria for bipolar disorder, and in others, the diagnosis is unclear. Severe mood dysregulation is a syndrome defined to capture the symptomatology of children whose diagnostic status with respect to bipolar disorder is uncertain, that is, those who have severe, nonepisodic irritability and the hyperarousal symptoms characteristic of mania but who lack the well-demarcated periods of elevated or irritable mood characteristic of bipolar disorder. Levels of impairment are comparable between youths with bipolar disorder and those with severe mood dysregulation. An emerging literature compares children with severe mood dysregulation and those with bipolar disorder in longitudinal course, family history, and pathophysiology. Longitudinal data in both clinical and community samples indicate that nonepisodic irritability in youths is common and is associated with an elevated risk for anxiety and unipolar depressive disorders, but not bipolar disorder, in adulthood. Data also suggest that youths with severe mood dysregulation have lower familial rates of bipolar disorder than do those with bipolar disorder. While youths in both patient groups have deficits in face emotion labeling and experience more frustration than do normally developing children, the brain mechanisms mediating these pathophysiologic abnormalities appear to differ between the two patient groups. No specific treatment for severe mood dysregulation currently exists, but verification of its identity as a syndrome distinct from bipolar disorder by further research should include treatment trials. JF - American Journal of Psychiatry AU - Leibenluft, Ellen AD - From the Section on Bipolar Spectrum Disorders, Emotion and Development Branch, NIMH Y1 - 2011 PY - 2011 DA - 2011 SP - 129 EP - 142 PB - American Psychiatric Publishing, Inc., 1000 Wilson Blvd., Ste. 1825 Arlington VA 22209-3901 USA VL - 168 IS - 2 SN - 0002-953X, 0002-953X KW - CSA Neurosciences Abstracts; Risk Abstracts KW - Emotions KW - Data processing KW - Anxiety KW - Affective disorders KW - Frustration KW - Brain KW - Children KW - Clinical trials KW - Mood KW - Genetics KW - Bipolar disorder KW - Boundaries KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904468043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Psychiatry&rft.atitle=Severe+Mood+Dysregulation%2C+Irritability%2C+and+the+Diagnostic+Boundaries+of+Bipolar+Disorder+in+Youths&rft.au=Leibenluft%2C+Ellen&rft.aulast=Leibenluft&rft.aufirst=Ellen&rft.date=2011-01-01&rft.volume=168&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mood; Emotions; Data processing; Anxiety; Bipolar disorder; Affective disorders; Frustration; Brain; Boundaries; Children; Clinical trials; Genetics ER - TY - JOUR T1 - Real-time Sonography With Electromagnetic Tracking Navigation for Biopsy of a Hepatic Neoplasm Seen Only on Arterial Phase Computed Tomography AN - 904467508; 14268929 AB - This case illustrates the ability of electromagnetic tracking navigation to localize difficult targets in real time during biopsy or ablation of lesions that are only transiently apparent on arterial phase computed tomography and may be unapparent on sonography. Readily available technology enabling multimodality registration to sonography allows for the use of positron emission tomographic, magnetic resonance imaging, and computed tomographic information during sonographically guided procedures and examinations. JF - Journal of Ultrasound in Medicine AU - Buckner, Carey A AU - Venkatesan, Aradhana AU - Locklin, Julia K AU - Wood, Bradford J AD - Center for Interventional Oncology and the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Maryland USA Y1 - 2011 PY - 2011 DA - 2011 SP - 253 EP - 256 PB - The American Institute of Ultrasound in Medicine VL - 30 IS - 2 SN - 0278-4297, 0278-4297 KW - Biotechnology and Bioengineering Abstracts KW - Computed tomography KW - Magnetic resonance imaging KW - Liver KW - Biopsy KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904467508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Ultrasound+in+Medicine&rft.atitle=Real-time+Sonography+With+Electromagnetic+Tracking+Navigation+for+Biopsy+of+a+Hepatic+Neoplasm+Seen+Only+on+Arterial+Phase+Computed+Tomography&rft.au=Buckner%2C+Carey+A%3BVenkatesan%2C+Aradhana%3BLocklin%2C+Julia+K%3BWood%2C+Bradford+J&rft.aulast=Buckner&rft.aufirst=Carey&rft.date=2011-01-01&rft.volume=30&rft.issue=2&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Journal+of+Ultrasound+in+Medicine&rft.issn=02784297&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Computed tomography; Liver; Biopsy; Ultrasound ER - TY - JOUR T1 - Serum C-Reactive Protein and Risk of Pancreatic Cancer in Two Nested, Case-Control Studies AN - 904467482; 14340340 AB - BACKGROUND: Many epidemiologic studies have examined the association between C-reactive protein (CRP) and risk of cancer with inconsistent results. METHODS: We conducted two nested, case-control studies in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC) and Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) to test whether prediagnostic circulating CRP concentrations were associated with pancreatic adenocarcinoma. Between 1985 and 2004, 311 cases occurred in ATBC and between 1994 and 2006, 182 cases occurred in PLCO. Controls (n = 510 in ATBC, n = 374 in PLCO) were alive at the time the case was diagnosed and were matched by age, date of blood draw, sex, and race. We used conditional logistic regression adjusted for smoking to calculate OR and 95% CI for pancreatic cancer. RESULTS: CRP concentrations (ng/mL) tended to be inversely or not associated with pancreatic cancer risk in ATBC, PLCO, and combined analyses [per standardized quintile increase in CRP, continuous OR = 0.94 (95% CI, 0.89-0.99), OR = 0.99 (95% CI, 0.95-1.04), OR = 0.98 (95% CI, 0.95-1.01), respectively]. In combined analyses, we observed a significant interaction (Pinteraction = 0.02) such that inverse associations were suggestive in younger (OR = 0.95; 95% CI, 0.90-1.01), but not older, participants. CONCLUSION: Our results do not support the hypothesis that higher CRP concentrations are associated with incident pancreatic cancer. IMPACT: Our results highlight the importance of investigating more specific biomarkers for inflammation that may reflect the biological mechanisms underlying pancreatic cancer in prospective cohort studies. Cancer Epidemiol Biomarkers Prev; 20(2); 359-69. [copy ]2010 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Douglas, Jason B AU - Silverman, Debra T AU - Weinstein, Stephanie J AU - Graubard, Barry I AU - Pollak, Michael N AU - Tao, Yuzhen AU - Virtamo, Jarmo AU - Albanes, Demetrius AU - Stolzenberg-Solomon, Rachael Z AD - Authors' Affiliations: Nutritional Epidemiology Branch, Occupational Epidemiology Branch, and Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 359 EP - 369 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 20 IS - 2 SN - 1055-9965, 1055-9965 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Bioindicators KW - Cancer KW - Lung KW - Prevention KW - Proteins KW - Smoking KW - Standards KW - ovarian carcinoma KW - pancreatic cancer KW - prevention KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904467482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Serum+C-Reactive+Protein+and+Risk+of+Pancreatic+Cancer+in+Two+Nested%2C+Case-Control+Studies&rft.au=Douglas%2C+Jason+B%3BSilverman%2C+Debra+T%3BWeinstein%2C+Stephanie+J%3BGraubard%2C+Barry+I%3BPollak%2C+Michael+N%3BTao%2C+Yuzhen%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius%3BStolzenberg-Solomon%2C+Rachael+Z&rft.aulast=Douglas&rft.aufirst=Jason&rft.date=2011-01-01&rft.volume=20&rft.issue=2&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Bioindicators; Smoking; Age; Prevention; pancreatic cancer; Lung; ovarian carcinoma; prevention; Proteins; Standards; Cancer ER - TY - JOUR T1 - Early life exposure to diagnostic radiation and ultrasound scans and risk of childhood cancer: case-control study AN - 904467251; 14371867 AB - OBJECTIVE: To examine childhood cancer risks associated with exposure to diagnostic radiation and ultrasound scans in utero and in early infancy (age 0-100 days). Design Case-control study. Setting England and Wales. Participants 2690 childhood cancer cases and 4858 age, sex, and region matched controls from the United Kingdom Childhood Cancer Study (UKCCS), born 1976-96. MAIN OUTCOME MEASURES: Risk of all childhood cancer, leukaemia, lymphoma, and central nervous system tumours, measured by odds ratios. RESULTS: Logistic regression models conditioned on matching factors, with adjustment for maternal age and child's birth weight, showed no evidence of increased risk of childhood cancer with in utero exposure to ultrasound scans. Some indication existed of a slight increase in risk after in utero exposure to x rays for all cancers (odds ratio 1.l4, 95% confidence interval 0.90 to 1.45) and leukaemia (1.36, 0.91 to 2.02), but this was not statistically significant. Exposure to diagnostic x rays in early infancy (0-100 days) was associated with small, non-significant excess risks for all cancers and leukaemia, as well as increased risk of lymphoma (odds ratio 5.14, 1.27 to 20.78) on the basis of small numbers. CONCLUSIONS: Although the results for lymphoma need to be replicated, all of the findings indicate possible risks of cancer from radiation at doses lower than those associated with commonly used procedures such as computed tomography scans, suggesting the need for cautious use of diagnostic radiation imaging procedures to the abdomen/pelvis of the mother during pregnancy and in children at very young ages. JF - British Medical Journal AU - Rajaraman, Preetha AU - Simpson, Jill AU - Neta, Gila AU - Berrington de Gonzalez, Amy AU - Ansell, Pat AU - Linet, Martha S AU - Ron, Elaine AU - Roman, Eve AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, Bethesda, MD 20892-7238, USA Y1 - 2011 PY - 2011 DA - 2011 SP - d472 PB - British Medical Association, BMA House Square London WC1H 9JP UK VL - 342 SN - 0959-8138, 0959-8138 KW - Health & Safety Science Abstracts; Toxicology Abstracts; Risk Abstracts KW - Abdomen KW - Age KW - Birth weight KW - Cancer KW - Central nervous system KW - Children KW - Computed tomography KW - Intrauterine exposure KW - Leukemia KW - Lymphoma KW - Models KW - Pelvis KW - Pregnancy KW - Prenatal experience KW - Regression analysis KW - Sex KW - Statistical analysis KW - Tumors KW - Ultrasound KW - birth weight KW - imaging KW - lymphoma KW - tumors KW - British Isles, Wales KW - British Isles, England KW - H 8000:Radiation Safety/Electrical Safety KW - R2 23060:Medical and environmental health KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904467251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Medical+Journal&rft.atitle=Early+life+exposure+to+diagnostic+radiation+and+ultrasound+scans+and+risk+of+childhood+cancer%3A+case-control+study&rft.au=Rajaraman%2C+Preetha%3BSimpson%2C+Jill%3BNeta%2C+Gila%3BBerrington+de+Gonzalez%2C+Amy%3BAnsell%2C+Pat%3BLinet%2C+Martha+S%3BRon%2C+Elaine%3BRoman%2C+Eve&rft.aulast=Rajaraman&rft.aufirst=Preetha&rft.date=2011-01-01&rft.volume=342&rft.issue=&rft.spage=d472&rft.isbn=&rft.btitle=&rft.title=British+Medical+Journal&rft.issn=09598138&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Central nervous system; Birth weight; Age; Abdomen; Statistical analysis; Intrauterine exposure; Tumors; Children; imaging; Cancer; Models; Pregnancy; Pelvis; Leukemia; Computed tomography; Regression analysis; Lymphoma; Ultrasound; Sex; Prenatal experience; birth weight; tumors; lymphoma; British Isles, England; British Isles, Wales ER - TY - JOUR T1 - H2AX phosphorylation in response to DNA double-strand break formation during bystander signalling: effect of microRNA knockdown AN - 904467061; 14453612 AB - Upon DNA double-strand break (DSB) formation, hundreds of H2AX molecules in the chromatin flanking the break site are phosphorylated on serine residue 139, termed gamma-H2AX, so that virtually every DSB site in a nucleus can be visualised within 10 min of its formation using an antibody to gamma-H2AX. One application of this sensitive assay is to examine the induction of DNA double-strand damage in subtle non-targeted cellular effects such as the bystander effect. Here whether microRNA (miRNA) serve as a primary signalling mechanism for bystander effect propagation by comparing matched human colon carcinoma cell lines with wild-type or depleted levels of mature miRNAs was investigated. No major differences were found in the levels of induced gamma-H2AX foci in the tested cell lines, indicating that though miRNAs play a role in bystander effect manifestation, they appear not to be the primary bystander signalling molecules in the formation of bystander effect-induced DSBs. JF - Radiation Protection Dosimetry AU - Dickey, Jennifer S AU - Zemp, Franz J AU - Altamirano, Alvin AU - Sedelnikova, Olga A AU - Bonner, William M AU - Kovalchuk, Olga AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 264 EP - 269 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 143 SN - 0144-8420, 0144-8420 KW - Biochemistry Abstracts 2: Nucleic Acids; Environment Abstracts KW - Antibodies KW - Chromatin KW - Colon KW - DNA KW - DNA damage KW - Dosimetry KW - Nuclei KW - Phosphorylation KW - Residues KW - Serine KW - Tumor cell lines KW - miRNA KW - ENA 14:Radiological Contamination KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904467061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=H2AX+phosphorylation+in+response+to+DNA+double-strand+break+formation+during+bystander+signalling%3A+effect+of+microRNA+knockdown&rft.au=Dickey%2C+Jennifer+S%3BZemp%2C+Franz+J%3BAltamirano%2C+Alvin%3BSedelnikova%2C+Olga+A%3BBonner%2C+William+M%3BKovalchuk%2C+Olga&rft.aulast=Dickey&rft.aufirst=Jennifer&rft.date=2011-01-01&rft.volume=143&rft.issue=&rft.spage=264&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - DNA damage; Antibodies; Tumor cell lines; Phosphorylation; Chromatin; Colon; Dosimetry; miRNA; DNA; Nuclei; Serine; Residues ER - TY - JOUR T1 - Chronic smoking, but not acute nicotine administration, modulates neural correlates of working memory AN - 904465505; 14167778 AB - Rationale: Beyond the amelioration of deprivation-induced impairments, and in contrast to effects on attentional processes, the cognitive-enhancing properties of nicotine on working memory (WM) operations remain unclear. Objectives: In an effort to elucidate potential enhancing effects, we explored the impact of transdermal nicotine on neural functioning in minimally deprived smokers and, in addition, assessed differences between smokers and non-smokers using a mixed block/event-related fMRI design that attempted to isolate specific central executive operations (attentional switch events) within general WM function (task blocks). Methods: In task blocks, participants performed a continuous counting paradigm that required the simultaneous maintenance of, and frequent switching of attentional focus between, two running tallies in WM on some trials. Cigarette smokers (n=30) were scanned twice, once each with a nicotine and placebo patch, while non-smokers (n=27) were scanned twice with no patch. Results: Across both groups, task blocks were associated with bilateral activation, notably in medial and lateral prefrontal cortex (PFC), anterior insula, and parietal regions, whereas individual attentional switch trials were associated with activation in a similar, but predominantly left-lateralized network. Within the smoker group, although nicotine increased heart rate, altered performance and mood, and reduced tobacco cravings, no acute drug (state-like) effect on brain activity was detected for either the task or switch effects. However, relative to non-smokers, smokers showed greater tonic activation in medial superior frontal cortex, right anterior insula, and bilateral anterior PFC throughout task blocks (trait-like effect). Conclusions: These data suggest smokers require recruitment of additional WM and supervisory control operations during task performance. JF - Psychopharmacology AU - Sutherland, Matthew T AU - Ross, Thomas J AU - Shakleya, Diaa M AU - Huestis, Marilyn A AU - Stein, Elliot A AD - Neuroimaging Research Branch, National Institute on Drug Abuse-Intramural Research Program, NIH/DHHS, 251 Bayview Blvd, Suite 200, Baltimore, MD, 21224, USA, sutherlm@nida.nih.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 29 EP - 42 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany VL - 213 IS - 1 SN - 0033-3158, 0033-3158 KW - Toxicology Abstracts; Animal Behavior Abstracts; CSA Neurosciences Abstracts KW - Brain mapping KW - Data processing KW - Cigarettes KW - Running KW - Functional magnetic resonance imaging KW - Recruitment KW - Heart rate KW - Cortex (frontal) KW - Enumeration KW - Short term memory KW - Mood KW - Smoking KW - Nicotine KW - Tobacco KW - Attention KW - Drugs KW - Cortex (prefrontal) KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25110:Biochemical & Neurophysiological Correlates, Lesions and Stimuli UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904465505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Chronic+smoking%2C+but+not+acute+nicotine+administration%2C+modulates+neural+correlates+of+working+memory&rft.au=Sutherland%2C+Matthew+T%3BRoss%2C+Thomas+J%3BShakleya%2C+Diaa+M%3BHuestis%2C+Marilyn+A%3BStein%2C+Elliot+A&rft.aulast=Sutherland&rft.aufirst=Matthew&rft.date=2011-01-01&rft.volume=213&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-010-2013-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-04-06 N1 - SubjectsTermNotLitGenreText - Brain mapping; Data processing; Cigarettes; Functional magnetic resonance imaging; Running; Heart rate; Recruitment; Cortex (frontal); Enumeration; Short term memory; Mood; Smoking; Nicotine; Tobacco; Drugs; Attention; Cortex (prefrontal) DO - http://dx.doi.org/10.1007/s00213-010-2013-6 ER - TY - JOUR T1 - The Epidemiology of Oral HPV Infection among a Multinational Sample of Healthy Men AN - 904464139; 14212157 AB - BACKGROUND: Oral human papillomavirus type-16 (HPV16) infection is a risk factor for oropharyngeal cancer. We examined oral HPV infection among healthy men. METHODS: Oral rinse/gargle specimens and questionnaire data were collected from 1,688 healthy men aged 18 to 74 (median = 31 years), from the United States, Mexico, and Brazil. HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58 and 59, and noncarcinogenic HPV types were detected using Roche Linear Array. RESULTS: Oral HPV DNA was detected in 67 of 1,680 (4.0%, 95% CI = 3.1%-5.0%) beta -globin-positive specimens; carcinogenic HPVs were detected in 1.3% (95% CI = 0.8%-2.0%; n = 22) and HPV16 was the most commonly detected carcinogenic HPV type (0.6%, 95% CI = 0.2%-1.1%; n = 10). The prevalence of oral HPV infection was similar by country except for HPV55, which had notably higher prevalence in Mexico (3.0%) than Brazil (0%) or the United States (0.2%). Oral HPV prevalence nonsignificantly increased over increasing age categories (Ptrend = 0.096). The strongest predictor of oral HPV was current tobacco use, which increased the odds 2.5-fold (95% CI = 1.4-4.4). Oral sexual behaviors were not associated with oral HPV infection. CONCLUSIONS: Oral HPV16 infection was rare in healthy men, especially at younger ages, and was positively associated with current tobacco use. IMPACT: Oral HPV appears to be about 10-fold less prevalent than infection at genital sites in men (4% vs. similar to 40%, respectively). It remains unclear whether this reflects reduced exposure or if the oral region is more resistant to HPV infection compared with anogenital sites. Cancer Epidemiol Biomarkers Prev; 20(1); 172-82. [copy ]2011 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Kreimer, Aimee R AU - Villa, Alessandro AU - Nyitray, Alan G AU - Abrahamsen, Martha AU - Papenfuss, Mary AU - Smith, Danelle AU - Hildesheim, Allan AU - Villa, Luisa L AU - Lazcano-Ponce, Eduardo AU - Giuliano, Anna R AD - Authors' Affiliations: National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 172 EP - 182 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 20 IS - 1 SN - 1055-9965, 1055-9965 KW - Virology & AIDS Abstracts; Risk Abstracts KW - Age KW - Anogenital KW - Bioindicators KW - Cancer KW - Carcinogenicity KW - DNA KW - Data processing KW - Epidemiology KW - Infection KW - Inventories KW - Risk factors KW - Sexual behavior KW - Tobacco KW - biomarkers KW - infection KW - males KW - oropharyngeal cancer KW - sexual behavior KW - Human papillomavirus 16 KW - USA KW - Mexico KW - Human papillomavirus KW - R2 23060:Medical and environmental health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904464139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=The+Epidemiology+of+Oral+HPV+Infection+among+a+Multinational+Sample+of+Healthy+Men&rft.au=Kreimer%2C+Aimee+R%3BVilla%2C+Alessandro%3BNyitray%2C+Alan+G%3BAbrahamsen%2C+Martha%3BPapenfuss%2C+Mary%3BSmith%2C+Danelle%3BHildesheim%2C+Allan%3BVilla%2C+Luisa+L%3BLazcano-Ponce%2C+Eduardo%3BGiuliano%2C+Anna+R&rft.aulast=Kreimer&rft.aufirst=Aimee&rft.date=2011-01-01&rft.volume=20&rft.issue=1&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-05-18 N1 - SubjectsTermNotLitGenreText - Inventories; Age; Data processing; Epidemiology; Anogenital; Risk factors; DNA; Tobacco; Infection; biomarkers; Sexual behavior; oropharyngeal cancer; Bioindicators; sexual behavior; Carcinogenicity; infection; males; Cancer; Human papillomavirus 16; Human papillomavirus; USA; Mexico ER - TY - JOUR T1 - Predicting the Future of Genetic Risk Prediction AN - 904464128; 14212151 JF - Cancer Epidemiology, Biomarkers & Prevention AU - Chatterjee, Nilanjan AU - Park, Ju-Hyun AU - Caporaso, Neil AU - Gail, Mitchell H AD - Authors' Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Rockville, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 3 EP - 8 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 20 IS - 1 SN - 1055-9965, 1055-9965 KW - Risk Abstracts KW - Bioindicators KW - prevention KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904464128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Predicting+the+Future+of+Genetic+Risk+Prediction&rft.au=Chatterjee%2C+Nilanjan%3BPark%2C+Ju-Hyun%3BCaporaso%2C+Neil%3BGail%2C+Mitchell+H&rft.aulast=Chatterjee&rft.aufirst=Nilanjan&rft.date=2011-01-01&rft.volume=20&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Bioindicators; prevention; Cancer ER - TY - JOUR T1 - Identification and Modulation of Voltage-Gated Ca2+ Currents in Zebrafish Rohon-Beard Neurons AN - 904463933; 14220383 AB - Electrically excitable cells have voltage-dependent ion channels on the plasma membrane that regulate membrane permeability to specific ions. Voltage-gated Ca2+ channels (VGCCs) are especially important as Ca2+ serves as both a charge carrier and second messenger. Zebrafish (Danio rerio) are an important model vertebrate for studies of neuronal excitability, circuits, and behavior. However, electrophysiological properties of zebrafish VGCCs remain largely unexplored because a suitable preparation for whole cell voltage-clamp studies is lacking. Rohon-Beard (R-B) sensory neurons represent an attractive candidate for this purpose because of their relatively large somata and functional homology to mammalian dorsal root ganglia (DRG) neurons. Transgenic zebrafish expressing green fluorescent protein in R-B neurons, (Isl2b:EGFP)ZC7, were used to identify dissociated neurons suitable for whole cell patch-clamp experiments. Based on biophysical and pharmacological properties, zebrafish R-B neurons express both high- and low-voltage-gated Ca2+ current (HVA- and LVA-ICa, respectively). Ni+-sensitive LVA-ICa occur in the minority of R-B neurons (30%) and omega -conotoxin GVIA-sensitive CaV2.2 (N-type) Ca2+ channels underlie the vast majority (90%) of HVA-ICa. To identify G protein coupled receptors (GPCRs) that modulate HVA-ICa, a panel of neurotransmitters was screened. Application of GABA/baclofen or serotonin produced a voltage-dependent inhibition while application of the mu-opioid agonist DAMGO resulted in a voltage-independent inhibition. Unlike in mammalian neurons, GPCR-mediated voltage-dependent modulation of ICa appears to be transduced primarily via a cholera toxin-sensitive G alpha subunit. These results provide the basis for using the zebrafish model system to understanding Ca2+ channel function, and in turn, how Ca2+ channels contribute to mechanosensory function. JF - Journal of Neurophysiology AU - Won, Yu-Jin AU - Ono, Fumihito AU - Ikeda, Stephen R AD - Section on Transmitter Signaling and Section on Model Synaptic Systems, Laboratory of Molecular Physiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 442 EP - 453 PB - American Physiological Society, 9650 Rockville Pike Bethesda MD 20814-3991 USA VL - 105 IS - 1 SN - 0022-3077, 0022-3077 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; CSA Neurosciences Abstracts KW - omega -Conotoxin KW - Calcium KW - Green fluorescent protein KW - Dorsal root ganglia KW - Calcium channels (voltage-gated) KW - Freshwater KW - Freshwater fish KW - Permeability KW - Neuromodulation KW - Second messengers KW - Plasma membranes KW - G protein-coupled receptors KW - Calcium channels KW - Neurotransmitters KW - Sensory neurons KW - gamma -Aminobutyric acid KW - Baclofen KW - Bacterial diseases KW - Calcium channels (N-type) KW - Receptors KW - Membrane permeability KW - Electrophysiology KW - Serotonin KW - Neurophysiology KW - Danio rerio KW - Neurons KW - Opioid receptors (type mu) KW - Calcium currents KW - Ganglia KW - N3 11029:Neurophysiology & biophysics KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904463933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurophysiology&rft.atitle=Identification+and+Modulation+of+Voltage-Gated+Ca2%2B+Currents+in+Zebrafish+Rohon-Beard+Neurons&rft.au=Won%2C+Yu-Jin%3BOno%2C+Fumihito%3BIkeda%2C+Stephen+R&rft.aulast=Won&rft.aufirst=Yu-Jin&rft.date=2011-01-01&rft.volume=105&rft.issue=1&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurophysiology&rft.issn=00223077&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Permeability; Neurons; Bacterial diseases; Receptors; Neurotransmitters; Electrophysiology; Freshwater fish; Ganglia; Neurophysiology; omega -Conotoxin; Calcium; Sensory neurons; Baclofen; gamma -Aminobutyric acid; Calcium channels (N-type); Dorsal root ganglia; Green fluorescent protein; Membrane permeability; Calcium channels (voltage-gated); Serotonin; Second messengers; Neuromodulation; G protein-coupled receptors; Plasma membranes; Calcium channels; Opioid receptors (type mu); Calcium currents; Danio rerio; Freshwater ER - TY - JOUR T1 - Circulating Markers of Interstitial Lung Disease and Subsequent Risk of Lung Cancer AN - 902365288; 15839747 AB - BACKGROUND: Inflammation and pulmonary diseases, including interstitial lung diseases, are associated with increased lung cancer risk. Circulating levels of surfactant protein-D (SP-D) and Krebs von Lungren-6 (KL-6) are elevated in interstitial lung disease patients and may be useful markers of processes contributing to lung cancer. METHODS: We conducted a nested case-control study, including 532 lung cancer cases, 582 matched controls, and 150 additional controls with chest X-ray (CXR) evidence of pulmonary scarring, in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Serum SP-D and KL-6 levels were measured using enzyme immunoassay. Logistic regression was used to estimate the associations of SP-D and KL-6 with lung cancer and CXR scarring. RESULTS: Cases had higher levels than controls for SP-D (median 118.7 vs. 105.4 ng/mL, P = 0.008) and KL-6 (372.0 vs. 325.8 mu g/mL, P = 0.001). Lung cancer risk increased with SP-D (Ptrend = 0.0003) and KL-6 levels (Ptrend = 0.005). Compared with the lowest quartile, lung cancer risk was elevated among those with the highest quartiles of SP-D (OR = 1.87, 95% CI: 1.32-2.64) or KL-6 (OR = 1.58, 95% CI: 1.11-2.25). Among controls, participants with CXR scarring were more likely than those without scarring to have elevated levels of SP-D (quartile 4 vs. quartile 1: OR = 1.67, 95% CI: 1.04-2.70, Ptrend = 0.05) but not of KL-6 (OR = 1.04, 95% CI: 0.64-1.68, Ptrend = 0.99). CONCLUSION: Circulating levels of SP-D and KL-6 are associated with subsequent lung cancer risk. IMPACT: Our findings support a potential role for interstitial lung disease in lung cancer etiology or early detection, but additional research is needed. Cancer Epidemiol Biomarkers Prev; 20(10); 2262-72. [copy ]2011 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Shiels, Meredith S AU - Chaturvedi, Anil K AU - Katki, Hormuzd A AU - Gochuico, Bernadette R AU - Caporaso, Neil E AU - Engels, Eric A AD - Authors' Affiliations: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville Y1 - 2011 PY - 2011 DA - 2011 SP - 2262 EP - 2272 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States VL - 20 IS - 10 SN - 1055-9965, 1055-9965 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Bioindicators KW - Cancer KW - Enzymes KW - Etiology KW - Immunoassays KW - Lung cancer KW - Ovarian carcinoma KW - Prevention KW - Surfactants KW - ovarian carcinoma KW - prevention KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902365288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Circulating+Markers+of+Interstitial+Lung+Disease+and+Subsequent+Risk+of+Lung+Cancer&rft.au=Shiels%2C+Meredith+S%3BChaturvedi%2C+Anil+K%3BKatki%2C+Hormuzd+A%3BGochuico%2C+Bernadette+R%3BCaporaso%2C+Neil+E%3BEngels%2C+Eric+A&rft.aulast=Shiels&rft.aufirst=Meredith&rft.date=2011-01-01&rft.volume=20&rft.issue=10&rft.spage=2262&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-12-03 N1 - SubjectsTermNotLitGenreText - Bioindicators; Prevention; Etiology; ovarian carcinoma; prevention; Enzymes; Ovarian carcinoma; Immunoassays; Surfactants; Cancer; Lung cancer ER - TY - JOUR T1 - Statins and serum cholesterol's associations with incident dementia and mild cognitive impairment AN - 902364723; 15895104 AB - BACKGROUND: Statin use and serum cholesterol reduction have been proposed as preventions for dementia and mild cognitive impairment (MCI). METHODS: 1604 and 1345 eligible participants from the Baltimore Longitudinal Study of Aging (BLSA) were followed after age 50 for a median time of around 25 years, to examine the incidence of dementia (n=259) and MCI (n=138), respectively. Statin use (ever-use and time-dependent use), total cholesterol levels (TC; first visit and time-dependent), TC change trajectory from first visit and high-density lipoprotein (HDL-C):TC ratio (first visit and time-dependent) were the main exposures of interest. Cox proportional hazards models were used. RESULTS: Participants with incident dementia had a higher first-visit TC compared with participants who remained free of dementia and MCI, while first-visit TC was higher among statin ever-users compared with never-users (age-unadjusted associations). Statin users had a two- to threefold lower risk of developing dementia (HR=0.41; 95% CI 0.18 to 0.92), but not MCI, when considering time-dependent 'statin use' with propensity score model adjustment. This association remained significant independently of serum cholesterol exposures. An elevated first-visit TC was associated with reduced MCI risk (upper quartile (Q4) vs Q1: HR=0.51; 95% CI 0.29 to 0.90). Compared with the lowest quartile (Q1: 0.00-0.19), HDL-C:TC (time-dependent) in (Q2: 0.19-0.24) was associated with reduced MCI risk (HR=0.58; 95% CI 0.34 to 0.98). Among men only, TC decline from first visit was significantly associated with increased dementia risk (HR=4.21; 95% CI 1.28 to 13.85). CONCLUSIONS: Statins may have multifactorial effects on dementia but not MCI risk. Future interventions may be warranted, and research should focus on optimal serum TC, HDL-C:TC ratio and TC change trajectories. JF - Journal of Epidemiology and Community Health AU - Beydoun, May A AU - Beason-Held, Lori L AU - Kitner-Triolo, Melissa H AU - Beydoun, Hind A AU - Ferrucci, Luigi AU - Resnick, Susan M AU - Zonderman, Alan B AD - National Institute on Aging, NIA/NIH/IRP, Baltimore, Maryland, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 949 EP - 957 PB - British Medical Association, BMA House Square London WC1H 9JP United Kingdom VL - 65 IS - 11 SN - 0143-005X, 0143-005X KW - Risk Abstracts KW - Age KW - cognitive ability KW - intervention KW - prevention KW - statins KW - USA, Maryland, Baltimore KW - dementia disorders KW - cholesterol KW - longitudinal studies KW - aging KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902364723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Epidemiology+and+Community+Health&rft.atitle=Statins+and+serum+cholesterol%27s+associations+with+incident+dementia+and+mild+cognitive+impairment&rft.au=Beydoun%2C+May+A%3BBeason-Held%2C+Lori+L%3BKitner-Triolo%2C+Melissa+H%3BBeydoun%2C+Hind+A%3BFerrucci%2C+Luigi%3BResnick%2C+Susan+M%3BZonderman%2C+Alan+B&rft.aulast=Beydoun&rft.aufirst=May&rft.date=2011-01-01&rft.volume=65&rft.issue=11&rft.spage=949&rft.isbn=&rft.btitle=&rft.title=Journal+of+Epidemiology+and+Community+Health&rft.issn=0143005X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Age; cognitive ability; intervention; prevention; statins; dementia disorders; cholesterol; longitudinal studies; aging; USA, Maryland, Baltimore ER - TY - JOUR T1 - Treating cancer with genetically engineered T cells AN - 902349874; 15892859 AB - Administration of ex vivo cultured, naturally occurring tumor-infiltrating lymphocytes (TILs) has been shown to mediate durable regression of melanoma tumors. However, the generation of TILs is not possible in all patients and there has been limited success in generating TIL in other cancers. Advances in genetic engineering have overcome these limitations by introducing tumor-antigen-targeting receptors into human T lymphocytes. Physicians can now genetically engineer lymphocytes to express highly active T-cell receptors (TCRs) or chimeric antigen receptors (CARs) targeting a variety of tumor antigens expressed in cancer patients. In this review, we discuss the development of TCR and CAR gene transfer technology and the expansion of these therapies into different cancers with the recent demonstration of the clinical efficacy of these treatments. JF - Trends in Biotechnology AU - Park, Tristen S AU - Rosenberg, Steven A AU - Morgan, Richard A AD - National Institutes of Health, National Cancer Institute, Surgery Branch, Bethesda, MD 20892, USA, rmorgan@mail.nih.gov PY - 2011 SP - 550 EP - 557 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 29 IS - 11 SN - 0167-7799, 0167-7799 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - T-cell receptor KW - Genetic engineering KW - Reviews KW - CAR gene KW - Antigen (tumor-associated) KW - Lymphocytes T KW - Tumor-infiltrating lymphocytes KW - Cancer KW - Melanoma KW - W 30905:Medical Applications KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902349874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Analysis+of+microbial+contamination+in+nanoparticle+formulations.&rft.au=Potter%2C+Timothy+M%3BDobrovolskaia%2C+Marina+A&rft.aulast=Potter&rft.aufirst=Timothy&rft.date=2011-01-01&rft.volume=697&rft.issue=&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=1940-6029&rft_id=info:doi/10.1007%2F978-1-60327-198-1_13 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-01-06 N1 - SubjectsTermNotLitGenreText - T-cell receptor; Reviews; Genetic engineering; Antigen (tumor-associated); CAR gene; Lymphocytes T; Tumor-infiltrating lymphocytes; Cancer; Melanoma DO - http://dx.doi.org/10.1016/j.tibtech.2011.04.009 ER - TY - JOUR T1 - Brain and Whole-Body Imaging in Rhesus Monkeys of 11C-NOP-1A, a Promising PET Radioligand for Nociceptin/Orphanin FQ Peptide Receptors AN - 902340623; 15786012 AB - Our laboratory developed (S)-3-(2'-fluoro-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]p y ran]-1-yl)-2-(2-fluorobenzyl)-N-methylpropanamide (11C-NOP-1A), a new radioligand for the nociceptin/orphanin FQ peptide (NOP) receptor, with high affinity (Ki, 0.15 nM) and appropriate lipophilicity (measured logD, 3.4) for PET brain imaging. Here, we assessed the utility of 11C-NOP-1A for quantifying NOP receptors in the monkey brain and estimated the radiation safety profile of this radioligand based on its biodistribution in monkeys. METHODS: Baseline and blocking PET scans were acquired from head to thigh for 3 rhesus monkeys for approximately 120 min after 11C-NOP-1A injection. These 6 PET scans were used to quantify NOP receptors in the brain and to estimate radiation exposure to organs of the body. In the blocked scans, a selective nonradioactive NOP receptor antagonist (SB-612111; 1 mg/kg intravenously) was administered before 11C-NOP-1A. In all scans, arterial blood was sampled to measure the parent radioligand 11C-NOP-1A. Distribution volume (VT; a measure of receptor density) was calculated with a compartment model using brain and arterial plasma data. Radiation-absorbed doses were calculated using the MIRD Committee scheme. RESULTS: After 11C-NOP-1A injection, peak uptake of radioactivity in the brain had a high concentration ( similar to 5 standardized uptake value), occurred early ( similar to 12 min), and thereafter washed out quickly. VT (mL . cm-3) was highest in the neocortex ( similar to 20) and lowest in hypothalamus and cerebellum ( similar to 13). SB-612111 blocked approximately 50%-70% of uptake and reduced VT in all brain regions to approximately 7 mL . cm-3. Distribution was well identified within 60 min of injection and stable for the remaining 60 min, consistent with only parent radioligand and not radiometabolites entering the brain. Whole-body scans confirmed that the brain had specific (i.e., displaceable) binding but could not detect specific binding in peripheral organs. The effective dose for humans estimated from the baseline scans in monkeys was 5.0 mu Sv/MBq. CONCLUSION: 11C-NOP-1A is a useful radioligand for quantifying NOP receptors in the monkey brain, and its radiation dose is similar to that of other 11C-labeled ligands for neuroreceptors. 11C-NOP-1A appears to be a promising candidate for measuring NOP receptors in the human brain. JF - Journal of Nuclear Medicine AU - Kimura, Yasuyuki AU - Fujita, Masahiro AU - Hong, Jinsoo AU - Lohith, Talakad G AU - Gladding, Robert L AU - Zoghbi, Sami S AU - Tauscher, Johannes A AU - Goebl, Nancy AU - Rash, Karen S AU - Chen, Zhaogen AU - Pedregal, Concepcion AU - Barth, Vanessa N AU - Pike, Victor W AU - Innis, Robert B AD - Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 1638 EP - 1645 PB - Society of Nuclear Medicine VL - 52 IS - 10 SN - 0161-5505, 0161-5505 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Blood KW - Brain KW - Cerebellum KW - Cortex KW - Data processing KW - Head KW - Neuroimaging KW - Nociceptin KW - Nuclear medicine KW - Positron emission tomography KW - Radiation KW - Radioactivity KW - Radioisotopes KW - Receptor density KW - Macaca mulatta KW - W 30910:Imaging KW - N3 11006:Neuroanatomy, histology & cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902340623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nuclear+Medicine&rft.atitle=Brain+and+Whole-Body+Imaging+in+Rhesus+Monkeys+of+11C-NOP-1A%2C+a+Promising+PET+Radioligand+for+Nociceptin%2FOrphanin+FQ+Peptide+Receptors&rft.au=Kimura%2C+Yasuyuki%3BFujita%2C+Masahiro%3BHong%2C+Jinsoo%3BLohith%2C+Talakad+G%3BGladding%2C+Robert+L%3BZoghbi%2C+Sami+S%3BTauscher%2C+Johannes+A%3BGoebl%2C+Nancy%3BRash%2C+Karen+S%3BChen%2C+Zhaogen%3BPedregal%2C+Concepcion%3BBarth%2C+Vanessa+N%3BPike%2C+Victor+W%3BInnis%2C+Robert+B&rft.aulast=Kimura&rft.aufirst=Yasuyuki&rft.date=2011-01-01&rft.volume=52&rft.issue=10&rft.spage=1638&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-12-14 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Data processing; Head; Nociceptin; Brain; Cerebellum; Blood; Cortex; Radiation; Radioisotopes; Positron emission tomography; Receptor density; Nuclear medicine; Radioactivity; Macaca mulatta ER - TY - JOUR T1 - Addiction Research Centres and the Nurturing of Creativity AN - 902085351; 201123856 AB - The aim of this paper is to present a concise account of the history, mission, structure and some recent achievements of the US National Institute on Alcohol Abuse and Alcoholism (NIAAA). Created by the US Congress 40 years ago, the NIAAA has evolved from an entity charged mainly with building a national system of alcoholism treatment services to one with responsibility for developing, nurturing and supporting the biomedical and behavioral science foundation necessary to reduce the significant domestic and global public health impact of alcohol use disorders. The NIAAA is unique in that it functions both as a funding agency, supporting research at universities and other external, or 'extramural' research institutions, and is also a research institution itself, where alcohol research is carried out in-house, or 'intramurally'. Of a $450.2 million 2009 Congressional Appropriation, approximately 90% was devoted toward the former and approximately 10% towards the latter objective. The current NIAAA Strategic Plan builds on a new organizing principle for long-range research planning, based on a life-span perspective that recognizes that human biology and behavior continue to change throughout life and changes occurring throughout the life-span affect individuals' drinking patterns as well as the decisions they may make to change their drinking habits or to seek help for alcohol use problems. Within this framework, major efforts are currently being devoted to educating practitioners on clinically useful, science-based assessment and treatment methods that exist today, and development of personalized new treatments for tomorrow. Adapted from the source document. JF - Addiction AU - Heilig, Markus AU - Warren, Kenneth R AU - Kunos, George AU - Silverman, Peter B AU - Hewitt, Brenda G AD - The National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 1052 EP - 1060 PB - Blackwell Publishing, Oxford UK VL - 106 IS - 6 SN - 0965-2140, 0965-2140 KW - Alcohol Abuse KW - Public Health KW - Behavior Modification KW - Biomedicine KW - Alcoholism KW - United States of America KW - Addiction KW - Creativity KW - Biology KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902085351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Addiction+Research+Centres+and+the+Nurturing+of+Creativity&rft.au=Heilig%2C+Markus%3BWarren%2C+Kenneth+R%3BKunos%2C+George%3BSilverman%2C+Peter+B%3BHewitt%2C+Brenda+G&rft.aulast=Heilig&rft.aufirst=Markus&rft.date=2011-01-01&rft.volume=106&rft.issue=6&rft.spage=1052&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2010.02995.x LA - English DB - Sociological Abstracts N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-28 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Alcohol Abuse; United States of America; Alcoholism; Biomedicine; Biology; Creativity; Addiction; Behavior Modification; Public Health DO - http://dx.doi.org/10.1111/j.1360-0443.2010.02995.x ER - TY - JOUR T1 - Pancreatic Cancer and Exposure to Dietary Nitrate and Nitrite in the NIH-AARP Diet and Health Study AN - 899166644; 15620264 AB - Nitrate and nitrite are precursors of N-nitroso compounds, which induce tumors of the pancreas in animals. The authors evaluated the relation of dietary nitrate and nitrite to pancreatic cancer risk in the NIH-AARP Diet and Health Study. Nitrate and nitrite intakes were assessed at baseline using a 124-item food frequency questionnaire. During approximately 10 years of follow-up between 1995 and 2006, 1,728 incident pancreatic cancer cases were identified. There was no association between total nitrate or nitrite intake and pancreatic cancer in men or women. However, men in the highest quintile of summed nitrate/nitrite intake from processed meat had a nonsignificantly elevated risk of pancreatic cancer (hazard ratio = 1.18, 95% confidence interval: 0.95, 1.47; P-trend = 0.11). The authors observed a stronger increase in risk among men for nitrate/nitrite intake from processed meat at ages 12-13 years (highest quintile vs. lowest: hazard ratio = 1.32, 95% confidence interval: 0.99, 1.76; P-trend = 0.11), though the relation did not achieve statistical significance. The authors found no associations between adult or adolescent nitrate or nitrite intake from processed meats and pancreatic cancer among women. These results provide modest evidence that processed meat sources of dietary nitrate and nitrite may be associated with pancreatic cancer among men and provide no support for the hypothesis in women. JF - American Journal of Epidemiology AU - Aschebrook-Kilfoy, Briseis AU - Cross, Amanda J AU - Stolzenberg-Solomon, Rachael Z AU - Schatzkin, Arthur AU - Hollenbeck, Albert R AU - Sinha, Rashmi AU - Ward, Mary H Y1 - 2011///1, PY - 2011 DA - 1, 2011 SP - 305 EP - 315 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 174 IS - 3 SN - 0002-9262, 0002-9262 KW - Toxicology Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - diet KW - nitrates KW - nitrites KW - nitroso compounds KW - pancreatic neoplasms KW - Diets KW - Nitrate KW - Inventories KW - pancreatic cancer KW - Age KW - Statistics KW - Nitrates KW - Adolescence KW - Food KW - Pancreatic cancer KW - tumors KW - Tumors KW - Meat KW - N-Nitroso compounds KW - Nitrites KW - meat KW - Nitrite KW - Adolescents KW - H 11000:Diseases/Injuries/Trauma KW - X 24320:Food Additives & Contaminants KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899166644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Pancreatic+Cancer+and+Exposure+to+Dietary+Nitrate+and+Nitrite+in+the+NIH-AARP+Diet+and+Health+Study&rft.au=Aschebrook-Kilfoy%2C+Briseis%3BCross%2C+Amanda+J%3BStolzenberg-Solomon%2C+Rachael+Z%3BSchatzkin%2C+Arthur%3BHollenbeck%2C+Albert+R%3BSinha%2C+Rashmi%3BWard%2C+Mary+H&rft.aulast=Aschebrook-Kilfoy&rft.aufirst=Briseis&rft.date=2011-01-01&rft.volume=174&rft.issue=3&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwr092 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Diets; Meat; Inventories; Nitrate; Age; N-Nitroso compounds; Statistics; Food; Adolescence; Pancreatic cancer; Tumors; Nitrite; pancreatic cancer; Nitrates; Nitrites; meat; tumors; Adolescents DO - http://dx.doi.org/10.1093/aje/kwr092 ER - TY - JOUR T1 - Bridging the Gap Between Genomics Discoveries and Clinical Care: Nurse Faculty are Key AN - 896181140; 201117161 AB - This is a pivotal time in health care. The speed at which newfound genomics knowledge is being discovered with potential applications to health is transforming healthcare delivery. The health status of the world's populations is a critical factor in the economies of nations, and all healthcare professionals will be affected by this transformative whirlwind of knowledge development. From the unfolding discovery of the genetic blueprint to the identification of genomic components of rare and common illnesses, this new knowledge is outpacing its own discovery, dissemination, absorption, and uptake by healthcare professionals. Adapted from the source document. JF - Journal of Nursing Scholarship AU - Jenkins, Jean AU - Bednash, Geraldine AU - Malone, Beverly AD - Senior Clinical Advisor, National Human Genome Research Institute, NIH Bethesda MDjean.jenkins@nih.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 1 EP - 2 PB - Wiley-Blackwell, UK VL - 43 IS - 1 SN - 1527-6546, 1527-6546 KW - Professional knowledge KW - Health professionals KW - Care delivery KW - Absorption KW - Discovery KW - Professors KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896181140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nursing+Scholarship&rft.atitle=Bridging+the+Gap+Between+Genomics+Discoveries+and+Clinical+Care%3A+Nurse+Faculty+are+Key&rft.au=Jenkins%2C+Jean%3BBednash%2C+Geraldine%3BMalone%2C+Beverly&rft.aulast=Jenkins&rft.aufirst=Jean&rft.date=2011-01-01&rft.volume=43&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nursing+Scholarship&rft.issn=15276546&rft_id=info:doi/10.1111%2Fj.1547-5069.2010.01362.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Professional knowledge; Discovery; Health professionals; Professors; Absorption; Care delivery DO - http://dx.doi.org/10.1111/j.1547-5069.2010.01362.x ER - TY - JOUR T1 - Licensing Electronic Journals through Non-Subscription-Agent "Go-Betweens" AN - 896170639; 201107507 AB - Conventional licensing wisdom says that libraries work either through subscription agents or directly through publishers. Many, however, are unaware of an alternative model, where for-profit or not-for-profit organizations handle pricing inquiries, terms and conditions, and often customer service on behalf of multiple publishers. Libraries are able to work with one middle person instead of many separate publisher contacts. This session described the whys and hows of this novel form of outsourcing from the perspective of both a librarian and a representative of one of these newer intermediaries. Adapted from the source document. JF - Serials Librarian AU - Landesman, Betty AU - Erzin, Pinar AU - Cipkowski, Pam AD - National Institutes of Health Library Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 198 EP - 202 PB - Taylor & Francis, Philadelphia PA VL - 60 IS - 1-4 SN - 0361-526X, 0361-526X KW - E-journals KW - Non-subscription agents KW - Marketing KW - Intermediaries KW - Customer service KW - Outsourcing KW - Acquisitions KW - Suppliers KW - Models KW - article KW - 9.11: TECHNICAL SERVICES - ACQUISITIONS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896170639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Serials+Librarian&rft.atitle=Licensing+Electronic+Journals+through+Non-Subscription-Agent+%22Go-Betweens%22&rft.au=Landesman%2C+Betty%3BErzin%2C+Pinar%3BCipkowski%2C+Pam&rft.aulast=Landesman&rft.aufirst=Betty&rft.date=2011-01-01&rft.volume=60&rft.issue=1-4&rft.spage=198&rft.isbn=&rft.btitle=&rft.title=Serials+Librarian&rft.issn=0361526X&rft_id=info:doi/10.1080%2F0361526X.2011.556034 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-27 N1 - CODEN - SELID4 N1 - SubjectsTermNotLitGenreText - Acquisitions; Customer service; Models; Suppliers DO - http://dx.doi.org/10.1080/0361526X.2011.556034 ER - TY - JOUR T1 - Peer Victimization and Academic Adjustment Among Early Adolescents: Moderation by Gender and Mediation by Perceived Classmate Support AN - 896166653; 201118506 AB - BACKGROUND: This study examined the moderating role of gender and the mediating role of perceived peer support in the association between peer victimization and academic adjustment. METHODS: Data were obtained from adolescents in grades 7 and 8 in the US 2005/2006 Health Behavior in School-aged Children study (N = 3436; mean age = 13.6 years). RESULTS: The magnitude of correlation between victimization and academic adjustment was -.155 for males and -.337 for females. After controlling for the socio-demographic variables, victimization had a significantly stronger influence on academic adjustment in females than in males. For both genders, perceived classmate support was negatively associated with peer victimization and positively associated with academic adjustment. Classmate support mediated the association between victimization and academic adjustment in males and was a partial mediator for females. CONCLUSION: These results provide support for efforts reducing victimization of female adolescents and fostering peer support in the school setting. Adapted from the source document. JF - Journal of School Health AU - Wang, Jing AU - Iannotti, Ronald J AU - Luk, Jeremy W AD - Prevention Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Building Room 7B13 MSC 7510, Bethesda, MD 20892-7510 wangji2@mail.nih.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 386 EP - 392 PB - Wiley-Blackwell, UK VL - 81 IS - 7 SN - 0022-4391, 0022-4391 KW - Classmates KW - Peer relationships KW - Gender KW - Adjustment KW - Adolescents KW - Victimization KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896166653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+School+Health&rft.atitle=Peer+Victimization+and+Academic+Adjustment+Among+Early+Adolescents%3A+Moderation+by+Gender+and+Mediation+by+Perceived+Classmate+Support&rft.au=Wang%2C+Jing%3BIannotti%2C+Ronald+J%3BLuk%2C+Jeremy+W&rft.aulast=Wang&rft.aufirst=Jing&rft.date=2011-01-01&rft.volume=81&rft.issue=7&rft.spage=386&rft.isbn=&rft.btitle=&rft.title=Journal+of+School+Health&rft.issn=00224391&rft_id=info:doi/10.1111%2Fj.1746-1561.2011.00606.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Adjustment; Victimization; Peer relationships; Classmates; Gender; Adolescents DO - http://dx.doi.org/10.1111/j.1746-1561.2011.00606.x ER - TY - JOUR T1 - Diagnosis and classification: There must be something left about which to argue -- reflections on Rutter (2011) AN - 896166426; 201117930 AB - Comments on an article in the same journal issue, "Child psychiatric diagnosis and classification: concepts, findings, challenges and potential" by Michael Rutter. Adapted from the source document. JF - The Journal of Child Psychology and Psychiatry AU - Pine, Daniel AD - National Institute of Mental Health, Bethesda, MD, USA Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 663 EP - 664 PB - Blackwell Publishing, Oxford UK VL - 52 IS - 6 SN - 0021-9630, 0021-9630 KW - Diagnosis KW - Classification KW - Children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896166426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=Diagnosis+and+classification%3A+There+must+be+something+left+about+which+to+argue+--+reflections+on+Rutter+%282011%29&rft.au=Pine%2C+Daniel&rft.aulast=Pine&rft.aufirst=Daniel&rft.date=2011-01-01&rft.volume=52&rft.issue=6&rft.spage=663&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Child+Psychology+and+Psychiatry&rft.issn=00219630&rft_id=info:doi/10.1111%2Fj.1469-7610.2011.02382.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-06-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JPPDAI N1 - SubjectsTermNotLitGenreText - Classification; Diagnosis; Children DO - http://dx.doi.org/10.1111/j.1469-7610.2011.02382.x ER - TY - JOUR T1 - Interplay of entrainment and rheology in snow avalanches: a numerical study AN - 893268118; 15630435 AB - A one-dimensional evolution equation for the slope-normal velocity profile of a streamwise uniform avalanche over an entrainable bed is derived. The boundary conditions are no slip at the bed, a stress-free surface and constant bed shear stress equal to the shear strength of the snow cover. The resulting equation is solved numerically by means of finite differences on a regular grid with a superposed fine grid near the erosion front that is adjusted at each time-step. The first exploratory simulations yield realistic entrainment rates and show that the entrainment rate tends towards a constant value while the flow depth and the velocity increase linearly with time for all investigated rheologies. It is shown that there indeed exists a rheology-independent asymptotic solution to the equation of motion of an entraining slab if the bottom friction is equal to the bed shear strength; the asymptotic acceleration is found to be half the downslope gravitational acceleration. The model can easily be extended to general path profiles, non-uniform flows and variable snow properties. JF - Annals of Glaciology AU - Issler, D AU - Pastor Perez, M AD - Norges Geotekniske Institutt and International Centre for Geohazards, PO Box 3930, Ullevaal Stadion, NO-0806 Oslo, Norway, di@nei.no Y1 - 2011 PY - 2011 DA - 2011 SP - 143 EP - 147 VL - 52 IS - 58 SN - 0260-3055, 0260-3055 KW - Aqualine Abstracts; Water Resources Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Meteorological & Geoastrophysical Abstracts KW - Entrainment KW - Boundary conditions KW - Shear Stress KW - Bottom friction KW - Shear KW - Shear stress KW - Mathematical models KW - Snow KW - Equations of motion KW - Velocity KW - Snow cover KW - Acceleration KW - Shear strength KW - Strength KW - Avalanches KW - Erosion KW - Rheology KW - Numerical simulations KW - Fronts KW - Velocity profiles KW - Profiles KW - Friction KW - AQ 00001:Water Resources and Supplies KW - SW 0835:Streamflow and runoff KW - M2 551.33:Glacial geology (551.33) KW - Q2 09124:Coastal zone management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893268118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Glaciology&rft.atitle=Interplay+of+entrainment+and+rheology+in+snow+avalanches%3A+a+numerical+study&rft.au=Issler%2C+D%3BPastor+Perez%2C+M&rft.aulast=Issler&rft.aufirst=D&rft.date=2011-01-01&rft.volume=52&rft.issue=58&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Annals+of+Glaciology&rft.issn=02603055&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Shear strength; Entrainment; Rheology; Mathematical models; Velocity profiles; Snow; Equations of motion; Bottom friction; Acceleration; Shear stress; Erosion; Avalanches; Fronts; Numerical simulations; Snow cover; Boundary conditions; Shear; Strength; Friction; Profiles; Shear Stress; Velocity ER - TY - JOUR T1 - Sensitive In Vitro System To Assess Morphological and Biochemical Effects of Praziquantel and Albendazole on Taenia solium Cysts AN - 893262025; 14155751 AB - Neurocysticercosis resulting from Taenia solium infections is a major cause of adult-acquired seizures worldwide. Disease is caused by larval cysts, and treatment consists of the anthelmintic drugs albendazole or praziquantel. There are no standard methods to assess drug activity to T. solium cysts in vitro. Morphological, functional, and biochemical changes that might reflect damaging (inhibiting, cytotoxic) drug effects were analyzed after exposure of cysts to albendazole sulfoxide (ABZ-SO), the major active metabolite of the drug in vivo, praziquantel (PZQ), or combinations of both. PZQ exposure led to a decrease in cyst size and inhibition of evagination, whereas ABZ-SO exposure resulted in minimal changes. Alkaline phosphatase (AP) is normally secreted by cysts, and both drugs inhibited AP secretion at concentrations of 5 and 50 ng/ml for PZQ and ABZ-SO, respectively. Some combinations of both drugs resulted in additive and/or synergistic activities. Parasite-specific antigen, detected in the cerebrospinal fluid and blood of infected patients, is also normally secreted by T. solium cysts. Antigen secretion was similarly inhibited by ABZ-SO and PZQ and a combination of both drugs, suggesting that inhibition of secretion is a common downstream consequence of the activities of both drugs. These studies establish quantitative methods to measure in vitro anthelmintic activity and suggest combination therapy with ABZ-SO and PZQ may have clinical benefit. JF - Antimicrobial Agents & Chemotherapy AU - Mahanty, S AU - Paredes, A AU - Marzal, M AU - Gonzalez, E AU - Rodriguez, S AU - Dorny, P AU - Guerra-Giraldez, C AU - Garcia, H H AU - Nash, T AD - Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 211 EP - 217 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 55 IS - 1 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Secretion KW - Seizures KW - Metabolites KW - Infection KW - Drug screening KW - Cysts KW - Albendazole KW - Blood KW - Cerebrospinal fluid KW - Cytotoxicity KW - Alkaline phosphatase KW - Cysticercosis KW - Praziquantel KW - Taenia KW - Taenia solium KW - Drugs KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893262025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Sensitive+In+Vitro+System+To+Assess+Morphological+and+Biochemical+Effects+of+Praziquantel+and+Albendazole+on+Taenia+solium+Cysts&rft.au=Mahanty%2C+S%3BParedes%2C+A%3BMarzal%2C+M%3BGonzalez%2C+E%3BRodriguez%2C+S%3BDorny%2C+P%3BGuerra-Giraldez%2C+C%3BGarcia%2C+H+H%3BNash%2C+T&rft.aulast=Mahanty&rft.aufirst=S&rft.date=2011-01-01&rft.volume=55&rft.issue=1&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Secretion; Seizures; Metabolites; Cysts; Drug screening; Infection; Albendazole; Blood; Cytotoxicity; Cerebrospinal fluid; Alkaline phosphatase; Cysticercosis; Praziquantel; Drugs; Taenia solium; Taenia ER - TY - JOUR T1 - Reward, dopamine and the control of food intake: implications for obesity AN - 885052046; 15459023 AB - The ability to resist the urge to eat requires the proper functioning of neuronal circuits involved in top-down control to oppose the conditioned responses that predict reward from eating the food and the desire to eat the food. Imaging studies show that obese subjects might have impairments in dopaminergic pathways that regulate neuronal systems associated with reward sensitivity, conditioning and control. It is known that the neuropeptides that regulate energy balance (homeostatic processes) through the hypothalamus also modulate the activity of dopamine cells and their projections into regions involved in the rewarding processes underlying food intake. It is postulated that this could also be a mechanism by which overeating and the resultant resistance to homoeostatic signals impairs the function of circuits involved in reward sensitivity, conditioning and cognitive control. JF - Trends in Cognitive Sciences AU - Volkow, Nora D AU - Wang, Gene-Jack AU - Baler, Ruben D Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 37 EP - 46 PB - Elsevier B.V. VL - 15 IS - 1 SN - 1364-6613, 1364-6613 KW - Physical Education Index; CSA Neurosciences Abstracts KW - Obesity KW - Eating disorders KW - Circuits KW - Dopamine KW - Conditioning KW - Energy balance KW - Reward KW - Scanning KW - Cognitive ability KW - Food intake KW - Reviews KW - Reinforcement KW - Diet KW - Trends KW - Neuropeptides KW - N3 11001:Behavioral and Cognitive Neuroscience KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885052046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Cognitive+Sciences&rft.atitle=Reward%2C+dopamine+and+the+control+of+food+intake%3A+implications+for+obesity&rft.au=Volkow%2C+Nora+D%3BWang%2C+Gene-Jack%3BBaler%2C+Ruben+D&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2011-01-01&rft.volume=15&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Trends+in+Cognitive+Sciences&rft.issn=13646613&rft_id=info:doi/10.1016%2Fj.tics.2010.11.001 LA - English DB - Physical Education Index N1 - Date revised - 2011-08-01 N1 - Last updated - 2013-08-23 N1 - SubjectsTermNotLitGenreText - Obesity; Conditioning; Scanning; Reward; Eating disorders; Diet; Trends; Dopamine; Energy balance; Food intake; Cognitive ability; Reviews; Reinforcement; Circuits; Neuropeptides DO - http://dx.doi.org/10.1016/j.tics.2010.11.001 ER - TY - JOUR T1 - Increased oxidative-modifications of cytosolic proteins in 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-exposed rat liver AN - 883044933; 15266684 AB - It is well established that 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) causes acute liver damage in animals and humans. The aim of this study was to identify and characterize oxidative modification and inactivation of cytosolic proteins in MDMA-exposed rats. Markedly increased levels of oxidized and nitrated cytosolic proteins were detected 12 h after the second administration of two consecutive MDMA doses (10 mg/kg each). Comparative 2-DE analysis showed markedly increased levels of biotin-N-methylimide-labeled oxidized cytosolic proteins in MDMA-exposed rats compared to vehicle-treated rats. Proteins in the 22 gel spots of strong intensities were identified using MS/MS. The oxidatively modified proteins identified include anti-oxidant defensive enzymes, a calcium-binding protein, and proteins involved in metabolism of lipids, nitrogen, and carbohydrates (glycolysis). Cytosolic superoxide dismutase was oxidized and its activity significantly inhibited following MDMA exposure. Consistent with the oxidative inactivation of peroxiredoxin, MDMA activated c-Jun N-terminal protein kinase and p38 kinase. Since these protein kinases phosphorylate anti-apoptotic Bcl-2 protein, their activation may promote apoptosis in MDMA-exposed tissues. Our results show for the first time that MDMA induces oxidative-modification of many cytosolic proteins accompanied with increased oxidative stress and apoptosis, contributing to hepatic damage. JF - Proteomics AU - Upreti, Vijay V AU - Moon, Kwan-Hoon AU - Yu, Li-Rong AU - Lee, Insong J AU - Eddington, Natalie D AU - Ye, Xiaoying AU - Veenstra, Timothy D AU - Song, Byoung-Joon AD - Pharmacokinetics and Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA, bj.song@nih.gov Y1 - 2011 PY - 2011 DA - 2011 SP - 202 EP - 211 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 11 IS - 2 SN - 1615-9861, 1615-9861 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Apoptosis KW - Peroxiredoxin KW - Enzymes KW - c-Jun protein KW - MDMA KW - Lipid metabolism KW - Superoxide dismutase KW - Oxidative stress KW - Transcription factors KW - Liver KW - Protein turnover KW - Protein kinase KW - proteomics KW - Carbohydrates KW - Bcl-2 protein KW - Glycolysis KW - Calcium-binding protein KW - Nitrogen KW - N3 11007:Neurobiology KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883044933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics&rft.atitle=Increased+oxidative-modifications+of+cytosolic+proteins+in+3%2C4-methylenedioxymethamphetamine+%28MDMA%2C+ecstasy%29-exposed+rat+liver&rft.au=Upreti%2C+Vijay+V%3BMoon%2C+Kwan-Hoon%3BYu%2C+Li-Rong%3BLee%2C+Insong+J%3BEddington%2C+Natalie+D%3BYe%2C+Xiaoying%3BVeenstra%2C+Timothy+D%3BSong%2C+Byoung-Joon&rft.aulast=Upreti&rft.aufirst=Vijay&rft.date=2011-01-01&rft.volume=11&rft.issue=2&rft.spage=202&rft.isbn=&rft.btitle=&rft.title=Proteomics&rft.issn=16159861&rft_id=info:doi/10.1002%2Fpmic.201000203 L2 - http://onlinelibrary.wiley.com/doi/10.1002/pmic.201000203/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - Apoptosis; Enzymes; Peroxiredoxin; c-Jun protein; MDMA; Lipid metabolism; Oxidative stress; Superoxide dismutase; Transcription factors; Liver; Protein kinase; Protein turnover; Bcl-2 protein; Carbohydrates; proteomics; Glycolysis; Calcium-binding protein; Nitrogen DO - http://dx.doi.org/10.1002/pmic.201000203 ER - TY - JOUR T1 - Imaging left ventricular tissue mechanics and hemodynamics during supine bicycle exercise using a combined tagging and phase-contrast MRI pulse sequence AN - 883041605; 15255984 AB - Imaging the left ventricular mechanical and hemodynamic response to the stress of exercise may offer early prognosis in select patients with cardiac disease. Here, we demonstrate the feasibility of obtaining simultaneous measurements of longitudinal strain and transvalvular blood velocity during supine bicycle exercise stress in a wide bore magnetic resonance scanner. Combining information from the two datasets, we observe that although the time to peak strain (33.28 +/- 1.86 versus 25.7 +/- 2.12 as % of R-R interval) and time to peak mitral inflow velocity (44.37 +/- 5.21 versus 35.5 +/- 4.19 as % of R-R interval) from R-wave of the QRS complex occurred earlier during stress, the time from peak strain to peak mitral inflow velocity was not statistically different (16.5 +/- 3.23 versus 13.4 +/- 3.06). Further, the percentage of longitudinal relaxation at peak mitral inflow velocity was higher during stress (63.5 +/- 7.72 versus 84.32 +/- 6.24). These results suggest that although diastole is shortened, early diastolic filling efficiency is augmented during exercise stress in normal volunteers in an effort to maintain stroke volume. Magn Reson Med, 2010. copyright 2010 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Sampath, Smita AU - Derbyshire, John Andrew AU - Ledesma-Carbayo, Maria J AU - McVeigh, Elliot R AD - Laboratory of Cardiac Energetics, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA, smita.sampath@yale.edu Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 51 EP - 59 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 65 IS - 1 SN - 1522-2594, 1522-2594 KW - Physical Education Index; Biotechnology and Bioengineering Abstracts KW - Heart KW - Statistics KW - Stroke KW - Magnetic resonance imaging KW - Mechanics KW - Prognosis KW - Stress KW - Velocity KW - Hemodynamics KW - Exercise KW - Strains KW - Physical training KW - Blood KW - Ventricle KW - Scanning KW - Relaxation KW - N.M.R. KW - Heart diseases KW - W 30910:Imaging KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883041605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Imaging+left+ventricular+tissue+mechanics+and+hemodynamics+during+supine+bicycle+exercise+using+a+combined+tagging+and+phase-contrast+MRI+pulse+sequence&rft.au=Sampath%2C+Smita%3BDerbyshire%2C+John+Andrew%3BLedesma-Carbayo%2C+Maria+J%3BMcVeigh%2C+Elliot+R&rft.aulast=Sampath&rft.aufirst=Smita&rft.date=2011-01-01&rft.volume=65&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22668 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22668/abstract LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2014-12-24 N1 - SubjectsTermNotLitGenreText - Statistics; Scanning; Relaxation; Mechanics; Hemodynamics; Velocity; Stress; Exercise; Strains; Heart; Blood; Ventricle; Magnetic resonance imaging; Stroke; Prognosis; N.M.R.; Heart diseases; Physical training DO - http://dx.doi.org/10.1002/mrm.22668 ER - TY - JOUR T1 - The contribution of chemical exchange to MRI frequency shifts in brain tissue AN - 883041578; 15255982 AB - Recent high-field MRI studies based on resonance frequency contrast have revealed brain structure with unprecedented detail. Although subtle magnetic susceptibility variations caused by iron and myelin seem to be important to this contrast, recent research on protein solutions suggests that chemical exchange between water and macromolecular protons may contribute substantially to the observed gray-white matter frequency contrast. To investigate this, we performed spectroscopic MRI experiments at 14 T on samples of fixed human visual cortex and fresh pig brain. To allow direct observation of any exchange-induced frequency shifts, these samples were soaked in reference chemicals (TSP and dioxane) that are assumed not to be involved in exchange. For both fresh and fixed tissues and with both reference chemicals, substantial negative exchange-induced gray-white matter frequency contrast (-6.3 to -13.5 ppb) was found, whereas intracortical contrast was negligible. The sign of the gray-white matter exchange-induced frequency difference was opposite to the overall gray-white matter frequency difference observed in vivo. This suggests that exchange contributes to, but is not sufficient to explain, the frequency contrast in vivo and tissue susceptibility differences may have a greater contribution than previously thought. The exchange-dependent contribution may report on tissue chemical composition and pH. Magn Reson Med, 2010. [copy 2010 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Shmueli, Karin AU - Dodd, Stephen J AU - Li, Tie-Qiang AU - Duyn, Jeff H AD - Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA, shmuelik@mail.nih.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 35 EP - 43 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 65 IS - 1 SN - 1522-2594, 1522-2594 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain KW - Cortex (visual) KW - Iron KW - Macromolecules KW - Magnetic resonance imaging KW - Magnetic susceptibility KW - Myelin KW - N.M.R. KW - Protons KW - pH effects KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883041578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Autophagy+monitoring+assay%3A+qualitative+analysis+of+MAP+LC3-I+to+II+conversion+by+immunoblot.&rft.au=McLeland%2C+Christopher+B%3BRodriguez%2C+Jamie%3BStern%2C+Stephan+T&rft.aulast=McLeland&rft.aufirst=Christopher&rft.date=2011-01-01&rft.volume=697&rft.issue=&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=1940-6029&rft_id=info:doi/10.1007%2F978-1-60327-198-1_21 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22604/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-06-29 N1 - SubjectsTermNotLitGenreText - Macromolecules; Myelin; Protons; Cortex (visual); Magnetic resonance imaging; Brain; Magnetic susceptibility; N.M.R.; pH effects; Iron DO - http://dx.doi.org/10.1002/mrm.22604 ER - TY - JOUR T1 - Building a standards-based and collaborative e-prescribing tool: MyRxPad AN - 883041565; 15163703 AB - MyRxPad (rxp.nlm.nih.gov) is a prototype application intended to enable a practitioner patient collaborative approach towards e-prescribing: patients play an active role by maintaining up-to-date and accurate medication lists. Prescribers make well-informed and safe prescribing decisions based on personal medication records contributed by patients. MyRxPad is thus the vehicle for collaborations with patients using MyMedicationList (MML). Integration with personal medication records in the context of e-prescribing is thus enabled. We present our experience in applying RxNorm in an e-prescribing setting: using standard names and codes to capture prescribed medication as well as extracting information from RxNorm to support medication-related clinical decision. JF - International Journal of Data Mining and Bioinformatics AU - Nelson, Stuart J AU - Zeng, Kelly AU - Kilbourne, John AD - US National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2011 PY - 2011 DA - 2011 SP - 252 EP - 265 PB - Inderscience Publishers Ltd., PO Box 735 Olney Bucks MK46 5WB United Kingdom VL - 5 IS - 3 SN - 1748-5673, 1748-5673 KW - Biotechnology and Bioengineering Abstracts KW - HEALTHCARE AND BIOSCIENCES KW - COMPUTING AND MATHEMATICS KW - Biosciences and Bioinformatics KW - Computing Science, Applications and Software KW - Healthcare and Medical Engineering KW - Integration KW - Data processing KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883041565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Data+Mining+and+Bioinformatics&rft.atitle=Building+a+standards-based+and+collaborative+e-prescribing+tool%3A+MyRxPad&rft.au=Nelson%2C+Stuart+J%3BZeng%2C+Kelly%3BKilbourne%2C+John&rft.aulast=Nelson&rft.aufirst=Stuart&rft.date=2011-01-01&rft.volume=157&rft.issue=&rft.spage=830&rft.isbn=&rft.btitle=&rft.title=Microbiology&rft.issn=13500872&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Integration; Data processing; Bioinformatics DO - http://dx.doi.org/10.1504/IJDMB.2011.040383 ER - TY - JOUR T1 - Blockade of brain angiotensin II AT sub(1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications) AN - 883041038; 15329287 AB - Poor adaptation to stress, alterations in cerebrovascular function and excessive brain inflammation play critical roles in the pathophysiology of many psychiatric and neurological disorders such as major depression, schizophrenia, post traumatic stress disorder, Parkinson's and Alzheimer's diseases and traumatic brain injury. Treatment for these highly prevalent and devastating conditions is at present very limited and many times inefficient, and the search for novel therapeutic options is of major importance. Recently, attention has been focused on the role of a brain regulatory peptide, Angiotensin, and in the translational value of the blockade of its physiological AT sub(1 receptors. In addition to its well-known cardiovascular effects, Angiotensin, through AT) sub(1) receptor stimulation, is a pleiotropic brain modulatory factor involved in the control of the reaction to stress, in the regulation of cerebrovascular flow and the response to inflammation. Excessive brain AT sub(1 receptor activity is associated with exaggerated sympathetic and hormonal response to stress, vulnerability to cerebrovascular ischemia and brain inflammation, processes leading to neuronal injury. In animal models, inhibition of brain AT) sub(1) receptor activity with systemically administered Angiotensin II receptor blockers is neuroprotective; it reduces exaggerated stress responses and anxiety, prevents stress-induced gastric ulcerations, decreases vulnerability to ischemia and stroke, reverses chronic cerebrovascular inflammation, and reduces acute inflammatory responses produced by bacterial endotoxin. These effects protect neurons from injury and contribute to increase the lifespan. Angiotensin II receptor blockers are compounds with a good margin of safety widely used in the treatment of hypertension and their anti-inflammatory and vascular protective effects contribute to reduce renal and cardiovascular failure. Inhibition of brain AT sub(1 receptors in humans is also neuroprotective, reducing the incidence of stroke, improving cognition and decreasing the progression of Alzheimer's disease. Blockade of AT) sub(1) receptors offers a novel and safe therapeutic approach for the treatment of illnesses of increasing prevalence and socioeconomic impact, such as mood disorders and neurodegenerative diseases of the brain. JF - Psychoneuroendocrinology AU - Saavedra, Juan M AU - Sanchez-Lemus, Enrique AU - Benicky, Julius AD - Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 Center Drive, Building 10, Room 2D-57, Bethesda, MD 20892, United States, Saavedrj@mail.nih.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 1 EP - 18 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 36 IS - 1 SN - 0306-4530, 0306-4530 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Endotoxins KW - Translation KW - Neurological diseases KW - Anxiety KW - Parkinson's disease KW - Alzheimer's disease KW - Animal models KW - Neuroprotection KW - Angiotensin KW - Cognition KW - Mood KW - Schizophrenia KW - Mental disorders KW - Angiotensin II receptors KW - Traumatic brain injury KW - Adaptations KW - Life span KW - Stroke KW - Brain KW - Stress KW - Renal failure KW - Ischemia KW - Angiotensin II KW - Inflammation KW - Socio-economic aspects KW - Neurodegenerative diseases KW - Movement disorders KW - Kidney KW - Attention KW - Hypertension KW - N3 11001:Behavioral and Cognitive Neuroscience KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883041038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychoneuroendocrinology&rft.atitle=Blockade+of+brain+angiotensin+II+AT+sub%281+receptors+ameliorates+stress%2C+anxiety%2C+brain+inflammation+and+ischemia%3A+Therapeutic+implications%29&rft.au=Saavedra%2C+Juan+M%3BSanchez-Lemus%2C+Enrique%3BBenicky%2C+Julius&rft.aulast=Saavedra&rft.aufirst=Juan&rft.date=2011-01-01&rft.volume=36&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Psychoneuroendocrinology&rft.issn=03064530&rft_id=info:doi/10.1016%2Fj.psyneuen.2010.10.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Endotoxins; Translation; Neurological diseases; Anxiety; Parkinson's disease; Alzheimer's disease; Animal models; Neuroprotection; Angiotensin; Cognition; Schizophrenia; Mood; Mental disorders; Angiotensin II receptors; Traumatic brain injury; Adaptations; Stroke; Life span; Brain; Renal failure; Stress; Ischemia; Angiotensin II; Inflammation; Neurodegenerative diseases; Socio-economic aspects; Movement disorders; Kidney; Attention; Hypertension DO - http://dx.doi.org/10.1016/j.psyneuen.2010.10.001 ER - TY - JOUR T1 - Layered electrophoretic transfer - A method for pre-analytic processing of histological sections AN - 883024504; 15266624 AB - Current technologies for measuring protein expression across a tissue section are based on MS or in situ detection such as immunohistochemistry. However, due to the inherent molecular complexity of tissue samples and the large dynamic range of protein expression in cells, current approaches are often unable to measure moderate- and low-abundant proteins. In addition, they do not provide information on the physico-chemical properties of the proteins studied. To address these problems, we are developing a new pre-analytic methodology termed layered electrophoretic transfer (LET) that selectively separates and processes proteins from an intact tissue section without compromising important two-dimensional histological information. LET offers two potential advantages over standard techniques: (i) A reduced complexity of the tissue proteome for subsequent analysis; (ii) An opportunity to assess the biochemical status of proteins as they exist in situ. As an initial proof-of-concept, we demonstrate here that the protein content from a mixture of molecular weight standards, human tissue lysates, and tissue sections can be successfully transferred and separated using LET, and further demonstrate that the method can be coupled with immunoblotting or MS for downstream measurements. LET technology represents a new pre-analytic tool for interrogating the proteome in tissue sections while preserving valuable spatial information. JF - Proteomics AU - Zhu, Liang AU - Tangrea, Michael A AU - Mukherjee, Sumana AU - Emmert-Buck, Michael R Y1 - 2011 PY - 2011 DA - 2011 SP - 883 EP - 889 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 11 IS - 5 SN - 1615-9861, 1615-9861 KW - Biotechnology and Bioengineering Abstracts KW - Immunoblotting KW - Molecular weight KW - Physicochemical properties KW - spatial discrimination KW - proteomics KW - Immunohistochemistry KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883024504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics&rft.atitle=Layered+electrophoretic+transfer+-+A+method+for+pre-analytic+processing+of+histological+sections&rft.au=Zhu%2C+Liang%3BTangrea%2C+Michael+A%3BMukherjee%2C+Sumana%3BEmmert-Buck%2C+Michael+R&rft.aulast=Zhu&rft.aufirst=Liang&rft.date=2011-01-01&rft.volume=11&rft.issue=5&rft.spage=883&rft.isbn=&rft.btitle=&rft.title=Proteomics&rft.issn=16159861&rft_id=info:doi/10.1002%2Fpmic.201000476 L2 - http://onlinelibrary.wiley.com/doi/10.1002/pmic.201000476/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - Immunoblotting; Molecular weight; Physicochemical properties; spatial discrimination; proteomics; Immunohistochemistry DO - http://dx.doi.org/10.1002/pmic.201000476 ER - TY - JOUR T1 - Targeting cyclooxygenases-1 and -2 in neuroinflammation: Therapeutic implications AN - 879470016; 14184357 AB - Neuroinflammation has been implicated in the pathogenesis or the progression of a variety of acute and chronic neurological and neurodegenerative disorders, including Alzheimer's disease. Prostaglandin H synthases or cyclooxygenases (COX -1 and COX-2) play a central role in the inflammatory cascade by converting arachidonic acid into bioactive prostanoids. In this review, we highlighted recent experimental data that challenge the classical view that the inducible isoform COX-2 is the most appropriate target to treat neuroinflammation. First, we discuss data showing that COX-2 activity is linked to anti-inflammatory and neuroprotective actions and is involved in the generation of novel lipid mediators with pro-resolution properties. Then, we review recent data demonstrating that COX-1, classically viewed as the homeostatic isoform, is actively involved in brain injury induced by pro-inflammatory stimuli including A beta , lipopolysaccharide, IL-1 beta , and TNF- alpha . Overall, we suggest revisiting the traditional views on the roles of each COX during neuroinflammation and we propose COX-1 inhibition as a viable therapeutic approach to treat CNS diseases with a marked inflammatory component. JF - Biochimie AU - Aied, Saba AU - Bosetti, Francesca AD - Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, NIH, 9 Memorial Drive, Bldg 9 Room 1S126, Bethesda, MD 20892, USA, frances@mail.nih.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 46 EP - 51 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 93 IS - 1 SN - 0300-9084, 0300-9084 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - prostaglandin H synthase KW - Cyclooxygenase-2 KW - Central nervous system KW - Neurological diseases KW - Data processing KW - Brain injury KW - Lipids KW - Alzheimer's disease KW - Prostaglandins KW - Interleukin 1 KW - Arachidonic acid KW - Neuroprotection KW - Cyclooxygenase-1 KW - Inflammation KW - Neurodegenerative diseases KW - Reviews KW - Lipopolysaccharides KW - beta -Amyloid KW - Tumor necrosis factor- alpha KW - N3 11008:Neurochemistry KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879470016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimie&rft.atitle=Targeting+cyclooxygenases-1+and+-2+in+neuroinflammation%3A+Therapeutic+implications&rft.au=Aied%2C+Saba%3BBosetti%2C+Francesca&rft.aulast=Aied&rft.aufirst=Saba&rft.date=2011-01-01&rft.volume=93&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Biochimie&rft.issn=03009084&rft_id=info:doi/10.1016%2Fj.biochi.2010.09.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Cyclooxygenase-2; prostaglandin H synthase; Central nervous system; Brain injury; Data processing; Neurological diseases; Lipids; Interleukin 1; Prostaglandins; Alzheimer's disease; Arachidonic acid; Neuroprotection; Inflammation; Cyclooxygenase-1; Neurodegenerative diseases; Reviews; Lipopolysaccharides; Tumor necrosis factor- alpha; beta -Amyloid DO - http://dx.doi.org/10.1016/j.biochi.2010.09.009 ER - TY - JOUR T1 - Evidence for Altered Numb Isoform Levels in Alzheimers Disease Patients and a Triple Transgenic Mouse Model AN - 874188686; 14752961 AB - The cell fate determinant Numb exists in four alternatively spliced variants that differ in the length of their PTB (phosphotyrosine-binding domain, either lacking or containing an 11 amino acid insertion) and PRR (proline-rich region, either lacking or containing a 48 amino acid insertion). We previously reported that Numb switches from isoforms containing the PTB insertion to isoforms lacking this insertion in neural cultures subjected to stress induced by trophic factor withdrawal. The switch in Numb isoforms enhances the generation of amyloid- peptide (A), the principle component of senile plaques in Alzheimers disease (AD). Here we examine the expression of the Numb isoforms in brains from AD patients and triple transgenic (3xTg) AD mice. We found that levels of the Numb isoforms lacking the PTB insertion are significantly elevated in the parietal cortex but not in the cerebellum of AD patients when compared to control subjects. Levels of Numb isoforms lacking the PTB insertion were also elevated in the cortex but not cerebellum of 12 month-old 3xTg AD mice with A deposits compared to younger 3xTg-AD mice and to non-transgenic mice. Exposure of cultured neurons to A resulted in an increase in the levels of Numb isoforms lacking the PTB domain, consistent with a role for A in the aberrant expression of Numb in vulnerable brain regions of AD patients and mice. Collectively, the data show that altered expression of Numb isoforms in vulnerable neurons occurs during AD pathogenesis and suggest a role for Numb in the disease process. JF - Journal of Alzheimer's Disease AU - Chigurupati, Srinivasulu AD - Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 349 EP - 361 PB - IOS Press, Nieuwe Hemweg 6B Amsterdam 1013 BG The Netherlands VL - 24 IS - 2 SN - 1387-2877, 1387-2877 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Numb protein KW - Deposits KW - Data processing KW - Amino acids KW - Alzheimer's disease KW - Cerebellum KW - Animal models KW - Brain KW - Cell culture KW - Transgenic mice KW - Alternative splicing KW - Cortex (parietal) KW - Neurodegenerative diseases KW - Neurons KW - Trophic factors KW - Cell fate KW - Senile plaques KW - W 30925:Genetic Engineering KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874188686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Alzheimer%27s+Disease&rft.atitle=Evidence+for+Altered+Numb+Isoform+Levels+in+Alzheimers+Disease+Patients+and+a+Triple+Transgenic+Mouse+Model&rft.au=Chigurupati%2C+Srinivasulu&rft.aulast=Chigurupati&rft.aufirst=Srinivasulu&rft.date=2011-01-01&rft.volume=10&rft.issue=10&rft.spage=M111.009035&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Proteomics&rft.issn=15359476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Numb protein; Deposits; Amino acids; Data processing; Alzheimer's disease; Brain; Animal models; Cerebellum; Cell culture; Transgenic mice; Alternative splicing; Cortex (parietal); Neurodegenerative diseases; Neurons; Trophic factors; Cell fate; Senile plaques ER - TY - JOUR T1 - Copyright Website LLC AN - 870996202; 201104720 AB - A review of the Copyright Website LLC (http://www.benedict.com/) is reviewed. The Copyright Website, launched in 1995 describes itself as "the ultimate copyright portal for real world, practical copyright information." It is far from being the "ultimate" portal, and is certainly not aimed at librarians; nonetheless, it contains some useful information that are worth a look. Adapted from the source document. JF - Technical Services Quarterly AU - Landesman, Betty AD - National Institutes of Health Library, Bethesda, MD Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 97 EP - 99 PB - Taylor & Francis, Philadelphia PA VL - 28 IS - 1 SN - 0731-7131, 0731-7131 KW - Web sites KW - Copyright KW - Usability KW - article KW - 16.1: COPYRIGHT UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/870996202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Services+Quarterly&rft.atitle=Copyright+Website+LLC&rft.au=Landesman%2C+Betty&rft.aulast=Landesman&rft.aufirst=Betty&rft.date=2011-01-01&rft.volume=28&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Technical+Services+Quarterly&rft.issn=07317131&rft_id=info:doi/10.1080%2F07317131.2011.524545 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2011-09-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Copyright; Web sites; Usability DO - http://dx.doi.org/10.1080/07317131.2011.524545 ER - TY - JOUR T1 - Next-generation imaging development for nanoparticle biodistribution measurements AN - 869579720; 14821184 AB - As nanotechnologies move closer to use in humans, quantitative imaging methods will play a vital role in answering questions of biodistribution. Accurate knowledge of the location and quantity of in vivo nanoconstructs and carriers is a challenging task, and new methods of quantitative imaging at appropriate resolutions are being developed and tested. Sustaining simultaneous advancement in both imaging development and nanotechnology research requires multidisciplinary research teams conducting experiments with interconnected goals. On an even greater scale, networks of multidisciplinary teams focused on similar issues of imaging and probe development offer opportunities for leveraging resources, as well as providing a forum for sharing ideas and creating consensus on solutions to common challenges. The Network for Translational Research (NTR): Optical Imaging in Multimodal Platforms from the National Cancer Institute is just such a network. Four multidisciplinary centers are accepting the challenges of developing and optimizing multimodal imaging hardware and software along with imaging probe development. These efforts are similar to the efforts that will be required for future studies of in vivo nanoparticle biodistribution. In addition to technology development and optimization, the network is organized to confront the challenges of validation of the imaging hardware and associated imaging agents, similar to the methods needed for validating nanomedicine. WIREs Nanomed Nanobiotechnol 2011 3 5-10 JF - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology AU - Tandon, Pushpa AU - Nordstrom, Robert J AD - National Cancer Institute, National Institutes of Health, Cancer Imaging Program, Bethesda, MD, USA, tandonp@mail.nih.gov Y1 - 2011/01/01/ PY - 2011 DA - 2011 Jan 01 SP - 5 EP - 10 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK VL - 3 IS - 1 SN - 1939-0041, 1939-0041 KW - Biotechnology and Bioengineering Abstracts KW - Translation KW - Computer programs KW - software KW - Computed tomography KW - Probes KW - nanoparticles KW - nanotechnology KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869579720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.atitle=Next-generation+imaging+development+for+nanoparticle+biodistribution+measurements&rft.au=Tandon%2C+Pushpa%3BNordstrom%2C+Robert+J&rft.aulast=Tandon&rft.aufirst=Pushpa&rft.date=2011-01-01&rft.volume=3&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.issn=19390041&rft_id=info:doi/10.1002%2Fwnan.117 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Computer programs; Translation; software; Computed tomography; Probes; nanoparticles; nanotechnology DO - http://dx.doi.org/10.1002/wnan.117 ER - TY - JOUR T1 - Diphosphoinositol polyphosphates: What are the mechanisms? AN - 864958404; 14694203 JF - Advances in Enzyme Regulation AU - Shears, Stephen B AU - Gokhale, Nikhil A AU - Wang, Huanchen AU - Zaremba, Angelika AD - Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, PO Box 12233, NC 27709, USA, Shears@niehs.nih.gov Y1 - 2011 PY - 2011 DA - 2011 SP - 13 EP - 25 PB - Elsevier Science Ltd., The Boulevard Kidlington Oxford OX5 1GB UK VL - 51 IS - 1 SN - 0065-2571, 0065-2571 KW - Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864958404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=Chicken+HS4+Insulators+Have+Minimal+Barrier+Function+Among+Progeny+of+Human+Hematopoietic+Cells+Transduced+With+an+HIV1-based+Lentiviral+Vector&rft.au=Uchida%2C+Naoya%3BWashington%2C+Kareem+N%3BLap%2C+Coen+J%3BHsieh%2C+Matthew+M%3BTisdale%2C+John+F&rft.aulast=Uchida&rft.aufirst=Naoya&rft.date=2011-01-01&rft.volume=19&rft.issue=1&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Molecular+Therapy&rft.issn=15250016&rft_id=info:doi/10.1038%2Fmt.2010.218 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 DO - http://dx.doi.org/10.1016/j.advenzreg.2010.09.008 ER - TY - JOUR T1 - Vehicle Motion Alarms: Necessity, Noise Pollution, or Both? AN - 864420320; 14389128 AB - Abstract not available. JF - Environmental Health Perspectives AU - Holzman, David C AD - David C. Holzman writes on science, medicine, energy, economics, and cars from Lexington and Wellfleet, MA. His work has appeared in Smithsonian, The Atlantic Monthly, and the Journal of the National Cancer Institute Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - A30 EP - A33 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 119 IS - 1 SN - 0091-6765, 0091-6765 KW - Pollution Abstracts; Environment Abstracts KW - Noise pollution KW - ENA 10:Noise Pollution KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864420320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Vehicle+Motion+Alarms%3A+Necessity%2C+Noise+Pollution%2C+or+Both%3F&rft.au=Holzman%2C+David+C&rft.aulast=Holzman&rft.aufirst=David&rft.date=2011-01-01&rft.volume=119&rft.issue=1&rft.spage=A30&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Noise pollution ER - TY - JOUR T1 - Hereditary paragangliomas. AN - 863416704; pmid-21358191 AB - Paragangliomas (PGL) and pheochromocytomas (PCC) are rare, usually benign tumors that originate from the neuroendocrine tissue along the paravertebral axis. Up to 35% of these tumors may be hereditary; they are associated with germline mutations in genes encoding subunits of the succinate dehydrogenase (SDH) enzyme complex in the context of the familial PGL syndromes, PGL1, 3 and 4 caused by mutations in the SDHD,SDHC and SDHB genes, respectively. Another familial PGL syndrome, PGL2, is caused by mutations in SDHAF2/SDH5, which encodes for a molecule that is an accessory to the function of the SDH enzyme and its SDHA subunit. Less frequently, mutations in the genes responsible for Von Hippel Lindau disease (VHL), multiple endocrine neoplasia type 2 (MEN2), and neurofibromatosis type 1 (NF1) are also found in patients with hereditary PGL and PCC. Recently mutations were found in the SDHA subunit in a limited number of patients with PGL and/or PCC. The SDHB, SDHC and SDHD gene mutations (but not SDHA) can also be found in patients with PGL and/or PCC and gastrointestinal stromal tumors (GISTs), also known as the Carney-Stratakis syndrome; SDHB mutations, in particular, may also predispose to thyroid and renal cancer, and possibly other tumors. A new gene was recently found to predispose to PGL and/or PCC when mutated is TMEM127. In this text, we provide an overview of the genetics of PGLs and related conditions with an emphasis on genetic risk assessment, prevention, and prognosis.Copyright © 2011 S. Karger AG, Basel. JF - Advances in oto-rhino-laryngology AU - Raygada, Margarita AU - Pasini, Barbara AU - Stratakis, Constantine A AD - Section on Clinical Genomics, Program Reproductive and Adult Endocrinology, National Institutes of Health, Bethesda, MD, USA. Y1 - 2011 PY - 2011 DA - 2011 SP - 99 EP - 106 VL - 70 SN - 0065-3071, 0065-3071 KW - Index Medicus KW - National Library of Medicine KW - Genetic Predisposition to Disease KW - Genetic Testing KW - Germ-Line Mutation KW - Humans KW - Multiple Endocrine Neoplasia Type 2a: genetics KW - Neurofibromatosis 1: genetics KW - *Paraganglioma: genetics KW - Prevalence KW - Prognosis KW - Risk Assessment KW - *Succinate Dehydrogenase: genetics KW - Syndrome KW - von Hippel-Lindau Disease: genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863416704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+oto-rhino-laryngology&rft.atitle=Hereditary+paragangliomas.&rft.au=Raygada%2C+Margarita%3BPasini%2C+Barbara%3BStratakis%2C+Constantine+A&rft.aulast=Raygada&rft.aufirst=Margarita&rft.date=2011-01-01&rft.volume=70&rft.issue=&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Advances+in+oto-rhino-laryngology&rft.issn=00653071&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Usher syndrome: hearing loss with vision loss. AN - 863416567; pmid-21358186 AB - Usher syndrome (USH) is a clinically heterogeneous condition characterized by sensorineural hearing loss, progressive retinal degeneration, and vestibular dysfunction. A minimum test battery is described as well as additional clinical evaluations that would provide comprehensive testing of hearing, vestibular function, and visual function in USH patients. USH is also genetically heterogeneous. At least nine genes have been identified with mutations that can cause USH. The proteins encoded by these genes are thought to interact with one another to form a network in the sensory cells of the inner ear and retina.Copyright © 2011 S. Karger AG, Basel. JF - Advances in oto-rhino-laryngology AU - Friedman, Thomas B AU - Schultz, Julie M AU - Ahmed, Zubair M AU - Tsilou, Ekaterini T AU - Brewer, Carmen C AD - Section on Human Genetics, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health (NIH), Rockville, MD, USA. friedman@nidcd.nih.gov Y1 - 2011 PY - 2011 DA - 2011 SP - 56 EP - 65 VL - 70 SN - 0065-3071, 0065-3071 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Disease Models, Animal KW - Genotype KW - Humans KW - Mice KW - Mutation KW - Phenotype KW - Usher Syndromes: diagnosis KW - *Usher Syndromes: genetics KW - Usher Syndromes: physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863416567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=Relationship+between+blood+and+myocardium+manganese+levels+during+manganese-enhanced+MRI+%28MEMRI%29+with+T1+mapping+in+rats&rft.au=Hu%2C+Tom+C-C%3BChuang%2C+Kai-Hsiang%3BYanasak%2C+Nathan%3BKoretsky%2C+Alan&rft.aulast=Hu&rft.aufirst=Tom&rft.date=2011-01-01&rft.volume=24&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=10991492&rft_id=info:doi/10.1002%2Fnbm.1554 LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Hereditary hearing loss with thyroid abnormalities. AN - 863416564; pmid-21358184 AB - Mutations in SLC26A4 can cause deafness and goiter in Pendred syndrome (PDS) or isolated non-syndromic enlargement of the vestibular aqueduct (NSEVA). PDS is one of the most common hereditary causes of deafness. It is characterized by autosomal-recessive inheritance of sensorineural hearing loss, enlarged vestibular aqueducts (EVA), and an iodide organification defect with or without goiter. The diagnosis is confirmed by detection of two mutant alleles of SLC26A4 in a patient with EVA. The perchlorate discharge test can detect the underlying thyroid biochemical defect and is useful for the evaluation of goiter or for the clinical diagnosis of PDS in a patient with a non-diagnostic SLC26A4 genotype. SLC26A4 encodes the pendrin polypeptide, an anion exchanger that, in recombinant expression systems, transports chloride, bicarbonate, and iodide. Investigation of pendrin function in the inner ear has been facilitated by the Slc26a4(Δ) (knockout) mouse model, but the exact mechanism of its hearing loss remains unclear, as does pendrin's principal transport function in the inner ear. Treatment of PDS is focused upon rehabilitation of hearing loss, and surveillance and management of goiter and, less commonly, hypothyroidism.Copyright © 2011 S. Karger AG, Basel. JF - Advances in oto-rhino-laryngology AU - Choi, Byung Yoon AU - Muskett, Julie AU - King, Kelly A AU - Zalewski, Christopher K AU - Shawker, Thomas AU - Reynolds, James C AU - Butman, John A AU - Brewer, Carmen C AU - Stewart, Andrew K AU - Alper, Seth L AU - Griffith, Andrew J AD - Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD, USA. Y1 - 2011 PY - 2011 DA - 2011 SP - 43 EP - 49 VL - 70 SN - 0065-3071, 0065-3071 KW - Index Medicus KW - National Library of Medicine KW - Alleles KW - Animals KW - Goiter, Nodular: genetics KW - Goiter, Nodular: rehabilitation KW - Hearing Loss, Sensorineural: genetics KW - Hearing Loss, Sensorineural: rehabilitation KW - Humans KW - Iodides: metabolism KW - *Membrane Transport Proteins: genetics KW - Mice KW - Mutation KW - Thyroid Gland: metabolism KW - *Vestibular Aqueduct: abnormalities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863416564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+oto-rhino-laryngology&rft.atitle=Hereditary+hearing+loss+with+thyroid+abnormalities.&rft.au=Choi%2C+Byung+Yoon%3BMuskett%2C+Julie%3BKing%2C+Kelly+A%3BZalewski%2C+Christopher+K%3BShawker%2C+Thomas%3BReynolds%2C+James+C%3BButman%2C+John+A%3BBrewer%2C+Carmen+C%3BStewart%2C+Andrew+K%3BAlper%2C+Seth+L%3BGriffith%2C+Andrew+J&rft.aulast=Choi&rft.aufirst=Byung&rft.date=2011-01-01&rft.volume=70&rft.issue=&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Advances+in+oto-rhino-laryngology&rft.issn=00653071&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Chronic rhinosinusitis. AN - 863416528; pmid-21358193 AB - Chronic rhinosinusitis (CRS) is a persistent inflammatory condition involving the nasal and paranasal mucosa. It is the most prevalent chronic condition in the United States. Sinonasal inflammation is also a common clinical presentation in a variety of systemic conditions. The etiology of CRS is complicated as a variety of extrinsic and intrinsic factors are frequently involved. Extrinsic factors include microbial infections that trigger abnormal immune responses. Intrinsic factors may predispose an individual to infection or exaggerated inflammatory responses. Several systemic conditions such as cystic fibrosis (CF), primary ciliary dyskinesia (PCD), asthma, immunohyper-responsiveness, and immunodeficiencies illustrate the role of genetic abnormalities in the development of CRS. Both common and rare genetic variants have been found in an association with CRS. A role for genetic factors is also supported by the demonstration of CRS clustering in families. Although the majority of CRS cases are considered to be idiopathic, the pathological evidence suggests that the chronic condition could be an overlapped presentation of multiple underlying mechanisms. Systemic conditions may have an impact on the incidence, severity, prognosis, or treatment of patients with CRS. Evaluation for underlying conditions may help the otolaryngologist manage the symptoms of CRS and optimize therapy.Copyright © 2011 S. Karger AG, Basel. JF - Advances in oto-rhino-laryngology AU - Wang, Xinjing AU - Cutting, Garry R AD - National Eye Institute, National Institutes of Health, Bethesda, MD 20892-1860, USA. wangx6@mail.nih.gov Y1 - 2011 PY - 2011 DA - 2011 SP - 114 EP - 121 VL - 70 SN - 0065-3071, 0065-3071 KW - Index Medicus KW - National Library of Medicine KW - Chronic Disease KW - Genetic Predisposition to Disease KW - Genetic Variation KW - Humans KW - Incidence KW - Prevalence KW - Prognosis KW - Rhinitis: diagnosis KW - *Rhinitis: etiology KW - Rhinitis: genetics KW - Rhinitis: therapy KW - Risk Factors KW - Sinusitis: diagnosis KW - *Sinusitis: etiology KW - Sinusitis: genetics KW - Sinusitis: therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863416528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+oto-rhino-laryngology&rft.atitle=Chronic+rhinosinusitis.&rft.au=Wang%2C+Xinjing%3BCutting%2C+Garry+R&rft.aulast=Wang&rft.aufirst=Xinjing&rft.date=2011-01-01&rft.volume=70&rft.issue=&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Advances+in+oto-rhino-laryngology&rft.issn=00653071&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Cancer Survivorship in the Age of YouTube and Social Media: A Narrative Analysis AN - 862592868; 201109052 AB - Background: As evidenced by the increasing popularity of YouTube (www.youtube.com), personal narratives shared through social media are an area of rapid development in communication among cancer survivors. Identifying the thematic and linguistic characteristics of YouTube cancer stories can provide a better understanding of this naturally occurring communication channel and inform social media communication efforts aiming to use personal stories to reach individuals with serious illnesses. Objective: The objective of our study was to provide an in-depth description of authentic personal cancer stories. Through a linguistically based narrative analysis of YouTube stories, the analysis explicates the common attributes of these narratives. Methods: Informed by narrative theories, we conducted an iterative, bottom-up analysis of 35 YouTube videos identified by the search terms "cancer survivor" and "cancer stories". A list of shared thematic and linguistic characteristics was identified and analyzed. Results: A subnarrative on the cancer diagnosis was present in 86% (30/35) of the stories under analysis. These diagnostic narratives were characterized by dramatic tension, emotional engagement, markers of the loss of agency or control, depersonalized reference to the medical personnel, and the unexpectedness of a cancer diagnosis. The analysis highlights the themes of story authenticity and emotional engagement in this online communication medium. Conclusions: Internet advances have enabled new and efficient exchange of personal stories, including the sharing of personal cancer experience among cancer survivors and their caregivers. The analytic results of this descriptive study point to the common characteristics of authentic cancer survivorship stories online. Furthermore, the results of this descriptive study may inform development of narrative-based communication, particularly in maintaining authenticity and emotional engagement. Adapted from the source document. JF - Journal of Medical Internet Research AU - Chou, Wen-Ying AU - Hunt, Yvonne AU - Folkers, Anna AU - Augustson, Erik AD - Health Communication & Informatics Research Branch, National Cancer Instit, National Instits Health, Bethesda, MD chouws@mail.nih.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 1 PB - Gunther Eysenbach MD MPH, Associate Professor, University of Toronto Senior Scientist, Centre for Global eHealth Innovation, Toronto, Canada VL - 13 IS - 1 SN - 1438-8871, 1438-8871 KW - Narratives KW - Linguistics KW - Survivors KW - Internet KW - Mass media KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862592868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Internet+Research&rft.atitle=Cancer+Survivorship+in+the+Age+of+YouTube+and+Social+Media%3A+A+Narrative+Analysis&rft.au=Chou%2C+Wen-Ying%3BHunt%2C+Yvonne%3BFolkers%2C+Anna%3BAugustson%2C+Erik&rft.aulast=Chou&rft.aufirst=Wen-Ying&rft.date=2011-01-01&rft.volume=13&rft.issue=1&rft.spage=e7&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Internet+Research&rft.issn=14388871&rft_id=info:doi/ L2 - http://www.jmir.org/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Cancer; Narratives; Mass media; Internet; Survivors; Linguistics ER - TY - JOUR T1 - History at the intersection of disability and public health: The case of John Galsworthy and disabled soldiers of the First World War AN - 862592664; 201110829 AB - The author presented an earlier version of this historical article to the Disability Section of the American Public Health Association (November 2009). It is part of his ongoing research in the social and cultural history of medicine as the field intersects with the history of disability, veterans, and public health, as well as current issues that touch all of these areas. This article introduces readers to perspectives on disability held by the British novelist John Galsworthy (1867-1933), which he developed primarily through his philanthropic support for and his compositions about rehabilitation programs for British and American soldiers disabled in the First World War (1914-1918). Readers will learn that Galsworthy's perspectives are as much about his identity as an individual with disabilities as they are about men disabled in the "war to end all wars." The rediscovery of Galsworthy's experiences and words more than 90 years after the end of World War I reveals how history is present today at the intersection of disability and public health. Indeed, the story of Galsworthy ultimately seeking to forget his own experiences during the "Great War," as well as the very physical and psychological disability caused by that conflict, can inspire public health professionals and disability rights advocates today to remember-indeed, to advocate for-men and women who served in battle and have returned home to realize renewed health and social participation despite permanent physical and psychological wounds. Readers will note that language used throughout this article to describe disability is period-specific and therefore not keeping with current conventions. [Copyright Elsevier Inc.] JF - Disability and Health Journal AU - Reznick, Jeffrey S AD - History of Medicine Division, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894-3819, USA Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 24 EP - 27 PB - Elsevier Inc., New York NY VL - 4 IS - 1 SN - 1936-5674, 1936-5674 KW - History KW - War KW - Rehabilitation KW - Disabled veterans KW - World War 1 KW - Soldiers KW - Advocacy services KW - UK KW - Disability KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862592664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Disability+and+Health+Journal&rft.atitle=History+at+the+intersection+of+disability+and+public+health%3A+The+case+of+John+Galsworthy+and+disabled+soldiers+of+the+First+World+War&rft.au=Reznick%2C+Jeffrey+S&rft.aulast=Reznick&rft.aufirst=Jeffrey&rft.date=2011-01-01&rft.volume=4&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Disability+and+Health+Journal&rft.issn=19365674&rft_id=info:doi/10.1016%2Fj.dhjo.2010.07.008 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Disability; Public health; Soldiers; Advocacy services; World War 1; UK DO - http://dx.doi.org/10.1016/j.dhjo.2010.07.008 ER - TY - JOUR T1 - Alcohol research: past, present, and future AN - 861571995; 14305287 AB - Created forty years ago, the National Institute on Alcohol Abuse and Alcoholism (NIAAA) has played a major role in the great strides made in the understanding, treatment, prevention, and public acceptance of alcohol-use disorders. Throughout most of U.S. history "habitual drunkenness" was viewed as a problem of moral degeneracy or character flaw inherent in the individual. However, the wealth of scientific evidence amassed throughout NIAAA's history has established alcoholism as a medical condition, that is, as a disease for which affected individuals should feel no shame or be treated with disdain. We look at the developments in alcohol epidemiology, typology, etiology, prevention, and treatment research over the past 40 years. We also discuss how NIAAA addresses alcohol disorders from a life-course framework, affecting all stages of the lifespan, from fetus through child, adolescent, and young adult, to midlife/senior adult, with each stage involving different risks, consequences, prevention efforts, and treatment strategies. JF - Annals of the New York Academy of Sciences AU - Gunzerath, Lorraine AU - Hewitt, Brenda G AU - Li, Ting-Kai AU - Warren, Kenneth R AD - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland. Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 1 EP - 23 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 1216 IS - 1 SN - 0077-8923, 0077-8923 KW - Risk Abstracts KW - Alcohol KW - Historical account KW - Etiology KW - prevention KW - young adults KW - Adolescents KW - alcoholism KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/861571995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Alcohol+research%3A+past%2C+present%2C+and+future&rft.au=Gunzerath%2C+Lorraine%3BHewitt%2C+Brenda+G%3BLi%2C+Ting-Kai%3BWarren%2C+Kenneth+R&rft.aulast=Gunzerath&rft.aufirst=Lorraine&rft.date=2011-01-01&rft.volume=1216&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1111%2Fj.1749-6632.2010.05832.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Document feature - figure 2 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Historical account; Alcohol; Etiology; prevention; young adults; Adolescents; alcoholism DO - http://dx.doi.org/10.1111/j.1749-6632.2010.05832.x ER - TY - JOUR T1 - Review of Florida red tide and human health effects AN - 860386831; 14360025 AB - This paper reviews the literature describing research performed over the past decade on the known and possible exposures and human health effects associated with Florida red tides. These harmful algal blooms are caused by the dinoflagellate, Karenia brevis, and similar organisms, all of which produce a suite of natural toxins known as brevetoxins. Florida red tide research has benefited from a consistently funded, long-term research program, that has allowed an interdisciplinary team of researchers to focus their attention on this specific environmental issue--one that is critically important to Gulf of Mexico and other coastal communities. This long-term interdisciplinary approach has allowed the team to engage the local community, identify measures to protect public health, take emerging technologies into the field, forge advances in natural products chemistry, and develop a valuable pharmaceutical product. The review includes a brief discussion of the Florida red tide organisms and their toxins, and then focuses on the effects of these toxins on animals and humans, including how these effects predict what we might expect to see in exposed people. JF - Harmful Algae AU - Fleming, Lora E AU - Kirkpatrick, Barbara AU - Backer, Lorraine C AU - Walsh, Cathy J AU - Nierenberg, Kate AU - Clark, John AU - Reich, Andrew AU - Hollenbeck, Julie AU - Benson, Janet AU - Cheng, Yung Sung AU - Naar, Jerome AU - Pierce, Richard AU - Bourdelais, Andrea J AU - Abraham, William M AU - Kirkpatrick, Gary AU - Zaias, Julia AU - Wanner, Adam AU - Mendes, Eliana AU - Shalat, Stuart AU - Hoagland, Porter AU - Stephan, Wendy AU - Bean, Judy AU - Watkins, Sharon AU - Clarke, Tainya AU - Byrne, Margaret AU - Baden, Daniel G AD - NSF NIEHS Oceans and Human Health Center, University of Miami, 4600 Rickenbacker Causeway, Miami, FL 33149, United States, lfleming@med.miami.edu lfleming@med.miami.edu lfleming@med.miami.edu lfleming@med.miami.edu lfleming@med.miami.edu lfleming@med.miami.edu lfleming@med.miami.edu lfleming@med.miami.edu lfleming@med.miami.edu lfleming@med.miami.edu Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 224 EP - 233 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 10 IS - 2 SN - 1568-9883, 1568-9883 KW - Toxicology Abstracts; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - PbTx KW - cm KW - COPD KW - ELISA KW - HAB KW - HABISS KW - K. brevis KW - km KW - LC-MS KW - mg/m3 KW - I14g/L KW - ng/m3 KW - NSP KW - OPD KW - Brevetoxins KW - Florida red tide KW - Harmful algal bloom (HAB) KW - Karenia brevis KW - Marine toxin diseases KW - Neurotoxic fish poisoning KW - Neurotoxic shellfish poisoning (NSP) KW - Red tide KW - Respiratory irritation KW - Shellfish poisoning KW - Noxious organisms KW - ASW, USA, Florida KW - Algal blooms KW - Red tides KW - Toxicants KW - Biological poisons KW - Phytoplankton KW - natural products KW - Metabolites KW - Toxins KW - Public health KW - ASW, Mexico Gulf KW - Literature reviews KW - Reviews KW - Dinoflagellates KW - Pharmaceuticals KW - Research programs KW - Algae KW - X 24370:Natural Toxins KW - O 1085:Biotechnology KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860386831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Harmful+Algae&rft.atitle=Review+of+Florida+red+tide+and+human+health+effects&rft.au=Fleming%2C+Lora+E%3BKirkpatrick%2C+Barbara%3BBacker%2C+Lorraine+C%3BWalsh%2C+Cathy+J%3BNierenberg%2C+Kate%3BClark%2C+John%3BReich%2C+Andrew%3BHollenbeck%2C+Julie%3BBenson%2C+Janet%3BCheng%2C+Yung+Sung%3BNaar%2C+Jerome%3BPierce%2C+Richard%3BBourdelais%2C+Andrea+J%3BAbraham%2C+William+M%3BKirkpatrick%2C+Gary%3BZaias%2C+Julia%3BWanner%2C+Adam%3BMendes%2C+Eliana%3BShalat%2C+Stuart%3BHoagland%2C+Porter%3BStephan%2C+Wendy%3BBean%2C+Judy%3BWatkins%2C+Sharon%3BClarke%2C+Tainya%3BByrne%2C+Margaret%3BBaden%2C+Daniel+G&rft.aulast=Fleming&rft.aufirst=Lora&rft.date=2011-01-01&rft.volume=10&rft.issue=2&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=Harmful+Algae&rft.issn=15689883&rft_id=info:doi/10.1016%2Fj.hal.2010.08.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2014-09-18 N1 - SubjectsTermNotLitGenreText - Noxious organisms; Algal blooms; Literature reviews; Toxicants; Red tides; Biological poisons; Phytoplankton; Metabolites; Public health; Brevetoxins; Reviews; Dinoflagellates; Pharmaceuticals; natural products; Research programs; Toxins; Algae; Karenia brevis; ASW, Mexico Gulf; ASW, USA, Florida DO - http://dx.doi.org/10.1016/j.hal.2010.08.006 ER - TY - JOUR T1 - Plasmodium falciparum: Nitric oxide modulates heme speciation in isolated food vacuoles AN - 860384980; 14369566 AB - Nitric oxide (NO) and NO-derived reactive nitrogen species (RNS) are present in the food vacuole (FV) of Plasmodium falciparum trophozoites. The product of PFL1555w, a putative cytochrome b 5, localizes in the FV membrane, similar to what was previously observed for the product of PF13_0353, a putative cytochrome b 5 reductase. These two gene products may contribute to NO generation by denitrification chemistry from nitrate and/or nitrite present in the erythrocyte cytosol. The possible coordination of NO to heme species present in the food vacuole was probed by resonance Raman spectroscopy. The spectroscopic data revealed that in situ generated NO interacts with heme inside the intact FVs to form ferrous heme nitrosyl complexes that influence intra-vacuolar heme solubility. The formation of heme nitrosyl complexes within the FV is a previously unrecognized factor that could affect the equilibrium between soluble and crystallized heme within the FV in vivo. JF - Experimental Parasitology AU - Ostera, Graciela AU - Tokumasu, Fuyuki AU - Teixeira, Clarissa AU - Collin, Nicolas AU - Sa, Juliana AU - Hume, Jennifer AU - Kumar, Sanjai AU - Ribeiro, Jose AU - Lukat-Rodgers, Gudrun S AU - Rodgers, Kenton R AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 1 EP - 8 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 127 IS - 1 SN - 0014-4894, 0014-4894 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources KW - Protozoa KW - Plasmodium falciparum KW - Malaria KW - Nitric oxide KW - Heme KW - Hemozoin KW - Antimalarials KW - Food vacuole KW - Speciation KW - Nitrate KW - Parasites KW - Cytochromes KW - Erythrocytes KW - Gene products KW - Cytochrome b KW - reductase KW - Denitrification KW - Nitrite KW - Data processing KW - Solubility KW - reactive nitrogen species KW - Fv KW - Raman spectroscopy KW - Resonance KW - Cytosol KW - Food vacuoles KW - Trophozoites KW - K 03410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860384980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+Parasitology&rft.atitle=Plasmodium+falciparum%3A+Nitric+oxide+modulates+heme+speciation+in+isolated+food+vacuoles&rft.au=Ostera%2C+Graciela%3BTokumasu%2C+Fuyuki%3BTeixeira%2C+Clarissa%3BCollin%2C+Nicolas%3BSa%2C+Juliana%3BHume%2C+Jennifer%3BKumar%2C+Sanjai%3BRibeiro%2C+Jose%3BLukat-Rodgers%2C+Gudrun+S%3BRodgers%2C+Kenton+R&rft.aulast=Ostera&rft.aufirst=Graciela&rft.date=2011-01-01&rft.volume=127&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Experimental+Parasitology&rft.issn=00144894&rft_id=info:doi/10.1016%2Fj.exppara.2010.05.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2014-11-12 N1 - SubjectsTermNotLitGenreText - Cytochromes; Parasites; Resonance; Denitrification; Erythrocytes; Gene products; Nitrate; Speciation; Solubility; Data processing; Heme; reactive nitrogen species; Fv; Cytochrome b; Raman spectroscopy; reductase; Cytosol; Nitric oxide; Food vacuoles; Nitrite; Trophozoites; Plasmodium falciparum DO - http://dx.doi.org/10.1016/j.exppara.2010.05.006 ER - TY - JOUR T1 - Database resources of the National Center for Biotechnology Information AN - 860379457; 14157185 AB - In addition to maintaining the GenBank registered nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI Web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central (PMC), Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Primer-BLAST, COBALT, Electronic PCR, OrfFinder, Splign, ProSplign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, dbVar, Epigenomics, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Trace Archive, Sequence Read Archive, Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus (GEO), Entrez Probe, GENSAT, Online Mendelian Inheritance in Man (OMIM), Online Mendelian Inheritance in Animals (OMIA), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART), IBIS, Biosystems, Peptidome, OMSSA, Protein Clusters and the PubChem suite of small molecule databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. JF - Nucleic Acids Research AU - Sayers, Eric W AU - Barrett, Tanya AU - Benson, Dennis A AU - Bolton, Evan AU - Bryant, Stephen H AU - Canese, Kathi AU - Chetvernin, Vyacheslav AU - Church, Deanna M AU - DiCuccio, Michael AU - Federhen, Scott AU - Feolo, Michael AU - Fingerman, Ian M AU - Geer, Lewis Y AU - Helmberg, Wolfgang AU - Kapustin, Yuri AU - Landsman, David AU - Lipman, David J AU - Lu, Zhiyong AU - Madden, Thomas L AU - Madej, Tom AU - Maglott, Donna R AU - Marchler-Bauer, Aron AU - Miller, Vadim AU - Mizrachi, Ilene AU - Ostell, James AU - Panchenko, Anna AU - Phan, Lon AU - Pruitt, Kim D AU - Schuler, Gregory D AU - Sequeira, Edwin AU - Sherry, Stephen T AU - Shumway, Martin AU - Sirotkin, Karl AU - Slotta, Douglas AU - Souvorov, Alexandre AU - Starchenko, Grigory AU - Tatusova, Tatiana A AU - Wagner, Lukas AU - Wang, Yanli AU - Wilbur, WJohn AU - Yaschenko, Eugene AU - Ye, Jian AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA and University Clinic of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Auenbruggerplatz 3, A-8036 Graz, Austria Y1 - 2011 PY - 2011 DA - 2011 SP - D38 EP - D51 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 39 SN - 1362-4962, 1362-4962 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Molecular modelling KW - Data processing KW - Heredity KW - Genotyping KW - DNA probes KW - Cancer KW - Gene expression KW - Computer programs KW - Databases KW - Chromosomes KW - nucleic acids KW - Cobalt KW - Human immunodeficiency virus 1 KW - Polymerase chain reaction KW - Conserved sequence KW - Taxonomy KW - Protein interaction KW - Internet KW - G 07740:Evolution KW - N 14815:Nucleotide Sequence KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860379457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Database+resources+of+the+National+Center+for+Biotechnology+Information&rft.au=Sayers%2C+Eric+W%3BBarrett%2C+Tanya%3BBenson%2C+Dennis+A%3BBolton%2C+Evan%3BBryant%2C+Stephen+H%3BCanese%2C+Kathi%3BChetvernin%2C+Vyacheslav%3BChurch%2C+Deanna+M%3BDiCuccio%2C+Michael%3BFederhen%2C+Scott%3BFeolo%2C+Michael%3BFingerman%2C+Ian+M%3BGeer%2C+Lewis+Y%3BHelmberg%2C+Wolfgang%3BKapustin%2C+Yuri%3BLandsman%2C+David%3BLipman%2C+David+J%3BLu%2C+Zhiyong%3BMadden%2C+Thomas+L%3BMadej%2C+Tom%3BMaglott%2C+Donna+R%3BMarchler-Bauer%2C+Aron%3BMiller%2C+Vadim%3BMizrachi%2C+Ilene%3BOstell%2C+James%3BPanchenko%2C+Anna%3BPhan%2C+Lon%3BPruitt%2C+Kim+D%3BSchuler%2C+Gregory+D%3BSequeira%2C+Edwin%3BSherry%2C+Stephen+T%3BShumway%2C+Martin%3BSirotkin%2C+Karl%3BSlotta%2C+Douglas%3BSouvorov%2C+Alexandre%3BStarchenko%2C+Grigory%3BTatusova%2C+Tatiana+A%3BWagner%2C+Lukas%3BWang%2C+Yanli%3BWilbur%2C+WJohn%3BYaschenko%2C+Eugene%3BYe%2C+Jian&rft.aulast=Sayers&rft.aufirst=Eric&rft.date=2011-01-01&rft.volume=39&rft.issue=&rft.spage=D38&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=13624962&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Genomes; Molecular modelling; Data processing; Heredity; DNA probes; Genotyping; Cancer; Gene expression; Databases; Computer programs; Chromosomes; nucleic acids; Cobalt; Conserved sequence; Polymerase chain reaction; Taxonomy; Internet; Protein interaction; Human immunodeficiency virus 1 ER - TY - JOUR T1 - Rapid Production of Clinical-Grade Gammaretroviral Vectors in Expanded Surface Roller Bottles Using a "Modified" Step-Filtration Process for Clearance of Packaging Cells AN - 856782874; 14391739 AB - Production of clinical-grade gammaretroviral vectors for ex vivo gene delivery requires a scalable process that can rapidly generate large amounts of vector supernatant, clear large numbers of residual packaging cells with minimal decreases in vector titer, and satisfy all current regulatory guidelines regarding product biosafety. To that end, we have developed a simplified method that is compliant with current good manufacturing practices for the production of clinical-grade gammaretroviral vectors in a clinical research environment. We validated a large-scale production platform utilizing 1,700-cm super(2) expanded surface roller bottles and a "modified" step-filtration process consisting of a 40/150- mu m dual-screen filter for aggregate removal followed by a Sepacell 500II leukocyte reduction filter for removal of residual packaging cells. This clarification process can clear at least 2x10 super(9) viable producer cells using a single filter set-up without any significant loss of titer post-filtration. This platform typically generates 18 liters of vector supernatant to support small-scale clinical trials, but can easily be scaled up to 70 liters during a single manufacturing run. To date, this platform has generated five clinical-grade gammaretroviral vector products, four of which are now being used in adoptive cell therapy clinical trials for the treatment of a variety of solid cancers. JF - Human Gene Therapy AU - Feldman, SA AU - Goff, S L AU - Xu, H AU - Black, MA AU - Kochenderfer, J N AU - Johnson, LA AU - Yang, J C AU - Wang, Q AU - Parkhurst, M R AU - Cross, S AU - Morgan, R A AU - Cornetta, K AU - Rosenberg, SA AD - Surgery Branch, 10 Center Drive, MSC 1201, Building 10, ACRF, 1B37A, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, feldmanst@mail.nih.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 107 EP - 115 VL - 22 IS - 1 SN - 1043-0342, 1043-0342 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Filters KW - Gene therapy KW - Gene transfer KW - Producer cells KW - Leukocytes KW - Clinical trials KW - Cancer KW - W 30905:Medical Applications KW - G 07880:Human Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856782874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Rapid+Production+of+Clinical-Grade+Gammaretroviral+Vectors+in+Expanded+Surface+Roller+Bottles+Using+a+%22Modified%22+Step-Filtration+Process+for+Clearance+of+Packaging+Cells&rft.au=Feldman%2C+SA%3BGoff%2C+S+L%3BXu%2C+H%3BBlack%2C+MA%3BKochenderfer%2C+J+N%3BJohnson%2C+LA%3BYang%2C+J+C%3BWang%2C+Q%3BParkhurst%2C+M+R%3BCross%2C+S%3BMorgan%2C+R+A%3BCornetta%2C+K%3BRosenberg%2C+SA&rft.aulast=Feldman&rft.aufirst=SA&rft.date=2011-01-01&rft.volume=22&rft.issue=1&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2010.064 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Filters; Gene therapy; Gene transfer; Producer cells; Leukocytes; Clinical trials; Cancer DO - http://dx.doi.org/10.1089/hum.2010.064 ER - TY - JOUR T1 - Human Parathyroid Hormone Is Secreted Primarily into the Bloodstream After Rat Parotid Gland Gene Transfer AN - 856782847; 14391736 AB - Hypoparathyroidism is a hormone deficiency syndrome that leads to low blood calcium levels and for which current replacement therapy is inadequate. Gene transfer to salivary glands leads to safe and abundant secretion of therapeutic protein into either saliva or the bloodstream. We previously reported the successful transduction of rat submandibular glands with an adenoviral vector encoding human parathyroid hormone (Ad.hPTH), but unfortunately most of the hPTH was secreted into saliva. Because submandibular and parotid glands are morphologically and functionally different, we hypothesized that hPTH sorting might be different in parotid glands. After 2 days, the pattern of hPTH secretion from transduced parotid glands of intact rats was reversed from that of transduced submandibular glands, that is, most transgenic hPTH was detected in serum (5 x 10 super(10) viral particles per gland; the saliva-to-serum ratio of total hPTH secreted was 0.04). Vector copies were localized to the targeted parotid glands, with none detected in liver or spleen. Ad.hPTH next was administered to parotid glands of parathyroidectomized rats. Two days after delivery no hPTH was detectable in saliva, but high levels were found in serum, leading to normalization of serum calcium and a significant increase in the urinary phosphorus-to-creatinine ratio. This study demonstrates for the first time differential sorting of transgenic hPTH between submandibular and parotid glands, suggesting that hPTH may be a valuable model protein for understanding the molecular basis of transgenic secretory protein sorting in these exocrine glands. We also show the clinical potential of salivary gland hPTH gene therapy for patients with hypoparathyroidism. JF - Human Gene Therapy AU - Adriaansen, J AU - Perez, P AU - Zheng, C AU - Collins, M T AU - Baum, B J AD - Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, NIH, Building 10, Room 1N113, Bethesda, MD 20892-1190, USA, bbaum@dir.nidcr.nih.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 84 EP - 92 VL - 22 IS - 1 SN - 1043-0342, 1043-0342 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Protein transport KW - Gene therapy KW - Secretion KW - Parotid gland KW - Spleen KW - Salivary gland KW - Hormones KW - Calcium (blood) KW - Expression vectors KW - Exocrine glands KW - Parathyroid hormone KW - Liver KW - Submandibular gland KW - Hypoparathyroidism KW - Saliva KW - W 30905:Medical Applications KW - G 07880:Human Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856782847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Human+Parathyroid+Hormone+Is+Secreted+Primarily+into+the+Bloodstream+After+Rat+Parotid+Gland+Gene+Transfer&rft.au=Adriaansen%2C+J%3BPerez%2C+P%3BZheng%2C+C%3BCollins%2C+M+T%3BBaum%2C+B+J&rft.aulast=Adriaansen&rft.aufirst=J&rft.date=2011-01-01&rft.volume=22&rft.issue=1&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2010.097 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Protein transport; Molecular modelling; Gene therapy; Secretion; Parotid gland; Spleen; Salivary gland; Calcium (blood); Hormones; Expression vectors; Exocrine glands; Liver; Parathyroid hormone; Submandibular gland; Saliva; Hypoparathyroidism DO - http://dx.doi.org/10.1089/hum.2010.097 ER - TY - JOUR T1 - Expression of heat shock protein (HSP 72kDa) during acute methamphetamine intoxication depends on brain hyperthermia: neurotoxicity or neuroprotection? AN - 856782171; 14264052 AB - In the present study, light and electron microscopy were used to examine heat shock protein (HSP 72kD) expression during acute methamphetamine (METH) intoxication in rats and evaluate its relationships with brain temperature and alterations in a number of other histochemical and morphological parameters. Freely moving rats received METH at the same dose (9mg/kg, sc) but at different ambient temperatures (23 and 29 degree C), showing a wide range of brain temperature elevations (37.6-42.5 degree C); brains were taken for histochemical and morphological evaluations at peak of brain temperature increase. We found that acute METH intoxication induces massive and wide-spread HSP expression in neural and glial cells examined in detail in the cortex, hippocampus, thalamus, and hypothalamus. In each of these structures, the number of HSP-positive cells tightly correlated with brain temperature elevation. The changes in HSP immunoreactivity were also tightly related to alterations in permeability of the blood-brain barrier, acute glial activation, and brain edema assessed by albumin and GFAP immunoreactivity and measuring tissue water content, respectively. While robust and generalized HSP production normally appears to be the part of an adaptive brain response associated with METH-induced metabolic activation, activation of this protective mechanism has its natural limits and could not counteract the damaging effects of oxidative stress, high temperature, and edema--the leading factors of METH-induced neurotoxicity. JF - Journal of Neural Transmission AU - Kiyatkin, Eugene A AU - Sharma, Hari S AD - Behavioral Neuroscience Branch, National Institute on Drug Abuse-Intramural Research Program, NIH, 333 Cassell Drive, Baltimore, MD, 21224, USA, ekiyatki@intra.nida.nih.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 47 EP - 60 PB - Springer-Verlag, Sachsenplatz 4-6 Vienna A-1201 Austria VL - 118 IS - 1 SN - 0300-9564, 0300-9564 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Albumin KW - Blood-brain barrier KW - Brain KW - Cortex KW - Edema KW - Glial fibrillary acidic protein KW - Heat shock proteins KW - Hippocampus KW - Immunoreactivity KW - Intoxication KW - Membrane permeability KW - Metabolic activation KW - Methamphetamine KW - Neuroprotection KW - Neurotoxicity KW - Oxidative stress KW - Temperature effects KW - Thalamus KW - Water content KW - X 24380:Social Poisons & Drug Abuse KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856782171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neural+Transmission&rft.atitle=Expression+of+heat+shock+protein+%28HSP+72kDa%29+during+acute+methamphetamine+intoxication+depends+on+brain+hyperthermia%3A+neurotoxicity+or+neuroprotection%3F&rft.au=Kiyatkin%2C+Eugene+A%3BSharma%2C+Hari+S&rft.aulast=Kiyatkin&rft.aufirst=Eugene&rft.date=2011-01-01&rft.volume=118&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neural+Transmission&rft.issn=03009564&rft_id=info:doi/10.1007%2Fs00702-010-0477-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Temperature effects; Intoxication; Heat shock proteins; Hippocampus; Blood-brain barrier; Brain; Glial fibrillary acidic protein; Membrane permeability; Edema; Neuroprotection; Water content; Thalamus; Methamphetamine; Cortex; Oxidative stress; Immunoreactivity; Neurotoxicity; Albumin; Metabolic activation DO - http://dx.doi.org/10.1007/s00702-010-0477-5 ER - TY - JOUR T1 - Transgenic animal models of neurodegeneration based on human genetic studies AN - 856779769; 14264051 AB - The identification of genes linked to neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD) and Parkinson's disease (PD) has led to the development of animal models for studying mechanism and evaluating potential therapies. None of the transgenic models developed based on disease-associated genes have been able to fully recapitulate the behavioral and pathological features of the corresponding disease. However, there has been enormous progress made in identifying potential therapeutic targets and understanding some of the common mechanisms of neurodegeneration. In this review, we will discuss transgenic animal models for AD, ALS, HD and PD that are based on human genetic studies. All of the diseases discussed have active or complete clinical trials for experimental treatments that benefited from transgenic models of the disease. JF - Journal of Neural Transmission AU - Harvey, Brandon K AU - Richie, Christopher T AU - Hoffer, Barry J AU - Airavaara, Mikko AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA, bharvey@intra.nida.nih.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 27 EP - 45 PB - Springer-Verlag, Sachsenplatz 4-6 Vienna A-1201 Austria VL - 118 IS - 1 SN - 0300-9564, 0300-9564 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Huntington's disease KW - Transgenic animals KW - Neurodegenerative diseases KW - Amyotrophic lateral sclerosis KW - Movement disorders KW - Parkinson's disease KW - Alzheimer's disease KW - Animal models KW - Clinical trials KW - W 30910:Imaging KW - N3 11023:Neurogenetics KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856779769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Occupational+cancer+monitoring%3A+a+unique+opportunity+to+protect+human+health&rft.au=Crosignani%2C+Paolo%3BBai%2C+Edoardo%3BOddone%2C+Enrico&rft.aulast=Crosignani&rft.aufirst=Paolo&rft.date=2011-01-01&rft.volume=68&rft.issue=&rft.spage=A112&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Transgenic animals; Huntington's disease; Neurodegenerative diseases; Movement disorders; Amyotrophic lateral sclerosis; Parkinson's disease; Alzheimer's disease; Animal models; Clinical trials DO - http://dx.doi.org/10.1007/s00702-010-0476-6 ER - TY - JOUR T1 - Silymarin use and liver disease progression in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis trial AN - 856778588; 14191996 AB - Background: Silymarin is the most commonly used herbal product for chronic liver disease; yet, whether silymarin protects against liver disease progression remains unclear. Aim: To assess the effects of silymarin use on subsequent liver disease progression in 1049 patients of the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis (HALT-C) trial who had advanced fibrosis or cirrhosis and had failed prior peginterferon plus ribavirin treatment. Methods: Patients recorded their use of silymarin at baseline and were followed up for liver disease progression (two point increase in Ishak fibrosis score across baseline, year 1.5, and year 3.5 biopsies) and over 8.65years for clinical outcomes. Results: At baseline, 34% of patients had used silymarin, half of whom were current users. Use of silymarin was associated (P<0.05) with male gender; oesophageal varices; higher ALT and albumin; and lower AST/ALT ratio, among other features. Baseline users had less hepatic collagen content on study biopsies and had less histological progression (HR: 0.57, 95% CI: 0.33-1.00; P-trend for longer duration of use=0.026). No effect was seen for clinical outcomes. Conclusions: Silymarin use among patients with advanced hepatitis C-related liver disease is associated with reduced progression from fibrosis to cirrhosis, but has no impact on clinical outcomes. JF - Alimentary Pharmacology and Therapeutics AU - Freedman, N D AU - Curto, T M AU - Morishima, C AU - Seeff, L B AU - Goodman, Z D AU - Wright, E C AU - Sinha, R AU - Everhart, JE AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA. Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 127 EP - 137 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 33 IS - 1 SN - 0269-2813, 0269-2813 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Albumin KW - Biopsy KW - Cirrhosis KW - Clinical trials KW - Collagen (type I) KW - Esophagus KW - Fibrosis KW - Hepatitis C KW - Liver diseases KW - Ribavirin KW - silymarin KW - A 01340:Antibiotics & Antimicrobials KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856778588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventive+Medicine&rft.atitle=Causes%2C+risks%2C+and+probabilities%3A+Probabilistic+concepts+of+causation+in+chronic+disease+epidemiology&rft.au=Parascandola%2C+Mark&rft.aulast=Parascandola&rft.aufirst=Mark&rft.date=2011-01-01&rft.volume=53&rft.issue=4-5&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=Preventive+Medicine&rft.issn=00917435&rft_id=info:doi/10.1016%2Fj.ypmed.2011.09.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Document feature - figure 2 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Esophagus; Cirrhosis; Liver diseases; Fibrosis; Albumin; Ribavirin; Biopsy; silymarin; Hepatitis C; Collagen (type I); Clinical trials DO - http://dx.doi.org/10.1111/j.1365-2036.2010.04503.x ER - TY - JOUR T1 - Trends in Hypertension Prevalence, Awareness, Treatment and Control in Older Mexican Americans, 1993-2005 AN - 856776715; 14255348 AB - Purpose: To describe trends in hypertension prevalence, awareness, treatment, and control among older Mexican Americans living in the Southwestern United States from 1993-1994 to 2004-2005. Methods: This study is a comparison between two separate cross-sectional cohorts of non-institutionalized Mexican Americans 75 years of age or older from the Hispanic Established Population for the Epidemiological Study of the Elderly (919 subjects from the 1993-1994 cohort and 738 from the 2004-2005 cohort). Data were collected on self-reported hypertension, measured blood pressure, medications, as well as sociodemographic and other health-related factors. Results: Hypertension prevalence increased from 73.0% in the period 1993-1994 to 78.4% in 2004-2005. Cross-cohort multivariate analyses showed that the higher odds of hypertension in the 2004-2005 cohort was attenuated by adding diabetes and obesity to the model. There was a significant increase in hypertension awareness among hypertensives (63.0% to 82.6%) and in control among treated hypertensives (42.5% to 55.4%). Cross-cohort multivariate analyses showed that the higher odds of control in 2004-2005 cohorts were accentuated by adding diabetes to the model. There were no significant changes in treatment rates (62.2% to 65.6%) Conclusion: Hypertension prevalence in very old Mexican Americans residing in the Southwestern United States was higher in 2004-2005 than in 1993-1994 and was accompanied by a significant increase in awareness and control rates. JF - Annals of Epidemiology AU - Ghatrif, Majd Al AU - Kuo, Yong-Fang AU - Snih, Soham Al AU - Raji, Mukaila A AU - Ray, Laura A AU - Markides, Kyriakos S AD - Sealy Center on Aging, University of Texas Medical Branch (UTMB), Galveston, majd.alghatrif@nih.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 15 EP - 25 PB - Elsevier Science, Box 882 New York NY 10159 USA VL - 21 IS - 1 SN - 1047-2797, 1047-2797 KW - Health & Safety Science Abstracts KW - Age KW - blood pressure KW - obesity KW - USA KW - diabetes mellitus KW - hypertension KW - elderly KW - Drugs KW - Ethnic groups KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856776715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Trends+in+Hypertension+Prevalence%2C+Awareness%2C+Treatment+and+Control+in+Older+Mexican+Americans%2C+1993-2005&rft.au=Ghatrif%2C+Majd+Al%3BKuo%2C+Yong-Fang%3BSnih%2C+Soham+Al%3BRaji%2C+Mukaila+A%3BRay%2C+Laura+A%3BMarkides%2C+Kyriakos+S&rft.aulast=Ghatrif&rft.aufirst=Majd&rft.date=2011-01-01&rft.volume=21&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2010.06.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Age; diabetes mellitus; blood pressure; hypertension; obesity; elderly; Drugs; Ethnic groups; USA DO - http://dx.doi.org/10.1016/j.annepidem.2010.06.002 ER - TY - JOUR T1 - MyD88-Dependent Signaling Protects against Anthrax Lethal Toxin-Induced Impairment of Intestinal Barrier Function AN - 856774827; 14156575 AB - MyD88-deficient mice were previously shown to have increased susceptibility to Bacillus anthracis infection relative to wild-type animals. To determine the mechanism by which MyD88 protects against B. anthracis infection, knockout mice were challenged with nonencapsulated, toxigenic B. anthracis or with anthrax toxins. MyD88-deficient mice had increased susceptibility to B. anthracis and anthrax lethal toxin but not to edema toxin. Lethal toxin alone induced marked multifocal intestinal ulcers in the knockout animals, compromising the intestinal epithelial barrier. The resulting enteric bacterial leakage in the knockout animals led to peritonitis and septicemia. Focal ulcers and erosion were also found in MyD88-heterozygous control mice but with far lower incidence and severity. B. anthracis infection also induced a similar enteric bacterial septicemia in MyD88-deficient mice but not in heterozygous controls. We show that lethal toxin and B. anthracis challenge induce bacteremia as a result of intestinal damage in MyD88-deficient mice. These results suggest that loss of the intestinal epithelial barrier and enteric bacterial septicemia may contribute to sensitizing MyD88-deficient mice to B. anthracis and that MyD88 plays a protective role against lethal toxin-induced impairment of intestinal barrier. JF - Infection and Immunity AU - Okugawa, Shu AU - Moayeri, Mahtab AU - Eckhaus, Michael A AU - Crown, Devorah AU - Miller-Randolph, Sharmina AU - Liu, Shihui AU - Akira, Shizuo AU - Leppla, Stephen H AD - Bacterial Toxins and Therapeutics Section, Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2011 PY - 2011 DA - 2011 SP - 118 EP - 124 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 79 IS - 1 SN - 0019-9567, 0019-9567 KW - Toxicology Abstracts; Immunology Abstracts KW - Anthrax lethal toxin KW - Leakage KW - Septicemia KW - MyD88 protein KW - Peritonitis KW - Bacteremia KW - Edema KW - Bacillus anthracis KW - Infection KW - Ulcers KW - Intestine KW - Anthrax KW - X 24370:Natural Toxins KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856774827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=MyD88-Dependent+Signaling+Protects+against+Anthrax+Lethal+Toxin-Induced+Impairment+of+Intestinal+Barrier+Function&rft.au=Okugawa%2C+Shu%3BMoayeri%2C+Mahtab%3BEckhaus%2C+Michael+A%3BCrown%2C+Devorah%3BMiller-Randolph%2C+Sharmina%3BLiu%2C+Shihui%3BAkira%2C+Shizuo%3BLeppla%2C+Stephen+H&rft.aulast=Okugawa&rft.aufirst=Shu&rft.date=2011-01-01&rft.volume=79&rft.issue=1&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2012-04-06 N1 - SubjectsTermNotLitGenreText - Anthrax lethal toxin; Leakage; Septicemia; MyD88 protein; Ulcers; Peritonitis; Intestine; Edema; Bacteremia; Anthrax; Infection; Bacillus anthracis ER - TY - JOUR T1 - dnaX36 Mutator of Escherichia coli: Effects of the Subunit of the DNA Polymerase III Holoenzyme on Chromosomal DNA Replication Fidelity AN - 856773141; 14191267 AB - The Escherichia coli dnaX36 mutant displays a mutator effect, reflecting a fidelity function of the dnaX-encoded subunit of the DNA polymerase III (Pol III) holoenzyme. We have shown that this fidelity function (i) applies to both leading- and lagging-strand synthesis, (ii) is independent of Pol IV, and (iii) is limited by Pol II. JF - Journal of Bacteriology AU - Gawel, Damian AU - Jonczyk, Piotr AU - Fijalkowska, Iwona J AU - Schaaper, Roel M AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, schaaper@niehs.nih.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 296 EP - 300 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 193 IS - 1 SN - 0021-9193, 0021-9193 KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - DNA biosynthesis KW - Fidelity KW - Replication KW - DNA-directed DNA polymerase KW - Escherichia coli KW - J 02310:Genetics & Taxonomy KW - N 14820:DNA Metabolism & Structure KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856773141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=dnaX36+Mutator+of+Escherichia+coli%3A+Effects+of+the+Subunit+of+the+DNA+Polymerase+III+Holoenzyme+on+Chromosomal+DNA+Replication+Fidelity&rft.au=Gawel%2C+Damian%3BJonczyk%2C+Piotr%3BFijalkowska%2C+Iwona+J%3BSchaaper%2C+Roel+M&rft.aulast=Gawel&rft.aufirst=Damian&rft.date=2011-01-01&rft.volume=193&rft.issue=1&rft.spage=296&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01191-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Number of references - 36 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - DNA biosynthesis; Fidelity; Replication; DNA-directed DNA polymerase; Escherichia coli DO - http://dx.doi.org/10.1128/JB.01191-10 ER - TY - JOUR T1 - Carcinogenic Effects of "Whole-Life" Exposure to Inorganic Arsenic in CD1 Mice AN - 856771627; 14155632 AB - In a previously developed mouse model, arsenic exposure in utero induces tumors at multiple sites in the offspring as adults, often duplicating human targets. However, human environmental inorganic arsenic exposure occurs during the entire life span, not just part of gestation. Thus, "whole-life" inorganic arsenic carcinogenesis in mice was studied. CD1 mice were exposed to 0, 6, 12, or 24 ppm arsenic in the drinking water 2 weeks prior to breeding, during pregnancy, lactation, and after weaning through adulthood. Tumors were assessed in offspring until 2 years of age. Arsenic induced dose-related increases in lung adenocarcinoma (both sexes), hepatocellular carcinoma (both sexes), gallbladder tumors (males), and uterine carcinomas. Arsenic induced dose-related increases in ovarian tumors (including carcinomas) starting with the lowest dose. Adrenal tumors increased at all doses (both sexes). Arsenic-induced lung and liver cancers were highly enriched for cancer stem cells, consistent with prior work with skin cancers stimulated by prenatal arsenic. Reproductive tract tumors overexpressed cyclooxygenase-2 and estrogen receptor- alpha . Arsenic target sites were remarkably similar to prior transplacental studies, although tumors from whole-life exposure were generally more aggressive and frequent. This may indicate that arsenic-induced events in utero dictate target site in some tissues, whereas other exposure periods of arsenic enhance incidence or progression, though other factors could be at play, like cumulative dose. Whole-life arsenic exposure induced tumors at dramatically lower external doses than in utero arsenic only while more realistically duplicating human exposure. JF - Toxicological Sciences AU - Tokar, Erik J AU - Diwan, Bhalchandra A AU - Ward, Jerrold M AU - Delker, Don A AU - Waalkes, Michael P AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, and National Toxicology Program, The National Institute of Environmental Health Sciences, Research Triangle Park, Raleigh, North Carolina 27709 Y1 - 2011 PY - 2011 DA - 2011 SP - 73 EP - 83 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 119 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Adenocarcinoma KW - Arsenic KW - X:24360 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856771627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics&rft.atitle=Layered+electrophoretic+transfer+-+A+method+for+pre-analytic+processing+of+histological+sections&rft.au=Zhu%2C+Liang%3BTangrea%2C+Michael+A%3BMukherjee%2C+Sumana%3BEmmert-Buck%2C+Michael+R&rft.aulast=Zhu&rft.aufirst=Liang&rft.date=2011-01-01&rft.volume=11&rft.issue=5&rft.spage=883&rft.isbn=&rft.btitle=&rft.title=Proteomics&rft.issn=16159861&rft_id=info:doi/10.1002%2Fpmic.201000476 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Arsenic ER - TY - JOUR T1 - Anti-Inflammatory Effects of Chronic Aspirin on Brain Arachidonic Acid Metabolites AN - 856768058; 14166840 AB - Pro-inflammatory and anti-inflammatory mediators derived from arachidonic acid (AA) modulate peripheral inflammation and its resolution. Aspirin (ASA) is a unique non-steroidal anti-inflammatory drug, which switches AA metabolism from prostaglandin E sub(2) (PGE sub(2)) and thromboxane B sub(2) (TXB sub(2)) to lipoxin A sub(4) (LXA sub(4)) and 15-epi-LXA sub(4). However, it is unknown whether chronic therapeutic doses of ASA are anti-inflammatory in the brain. We hypothesized that ASA would dampen increases in brain concentrations of AA metabolites in a rat model of neuroinflammation, produced by a 6-day intracerebroventricular infusion of bacterial lipopolysaccharide (LPS). In rats infused with LPS (0.5ng/h) and given ASA-free water to drink, concentrations in high-energy microwaved brain of PGE sub(2), TXB sub(2) and leukotriene B sub(4) (LTB sub(4)) were elevated. In rats infused with artificial cerebrospinal fluid, 6weeks of treatment with a low (10mg/kg/day) or high (100mg/kg/day) ASA dose in drinking water decreased brain PGE sub(2), but increased LTB sub(4), LXA sub(4) and 15-epi-LXA sub(4) concentrations. Both doses attenuated the LPS effects on PGE sub(2), and TXB sub(2). The increments in LXA sub(4) and 15-epi-LXA sub(4) caused by high-dose ASA were significantly greater in LPS-infused rats. The ability of ASA to increase anti-inflammatory LXA sub(4) and 15-epi-LXA sub(4) and reduce pro-inflammatory PGE sub(2) and TXB sub(2) suggests considering aspirin further for treating clinical neuroinflammation. JF - Neurochemical Research AU - Basselin, Mireille AU - Ramadan, Epolia AU - Chen, Mei AU - Rapoport, Stanley I AD - Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bldg. 9, Room 1S126, 9000 Rockville Pike, Bethesda, MD, 20892, USA, ramadanir@mail.nih.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 139 EP - 145 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 36 IS - 1 SN - 0364-3190, 0364-3190 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Thromboxanes KW - Beverages KW - Brain KW - Arachidonic acid KW - Metabolites KW - Prostaglandin E2 KW - Inflammation KW - Leukotriene B4 KW - Cerebrospinal fluid KW - Aspirin KW - Lipopolysaccharides KW - Drinking water KW - Nonsteroidal antiinflammatory drugs KW - Lipoxin A4 KW - J 02410:Animal Diseases KW - X 24370:Natural Toxins KW - N3 11008:Neurochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856768058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemical+Research&rft.atitle=Anti-Inflammatory+Effects+of+Chronic+Aspirin+on+Brain+Arachidonic+Acid+Metabolites&rft.au=Basselin%2C+Mireille%3BRamadan%2C+Epolia%3BChen%2C+Mei%3BRapoport%2C+Stanley+I&rft.aulast=Basselin&rft.aufirst=Mireille&rft.date=2011-01-01&rft.volume=36&rft.issue=1&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Neurochemical+Research&rft.issn=03643190&rft_id=info:doi/10.1007%2Fs11064-010-0282-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2012-04-06 N1 - SubjectsTermNotLitGenreText - Thromboxanes; Beverages; Brain; Arachidonic acid; Metabolites; Prostaglandin E2; Inflammation; Cerebrospinal fluid; Leukotriene B4; Aspirin; Lipopolysaccharides; Drinking water; Lipoxin A4; Nonsteroidal antiinflammatory drugs DO - http://dx.doi.org/10.1007/s11064-010-0282-4 ER - TY - JOUR T1 - Moving Closer to a Public Health Model of Language and Learning Disabilities: The Role of Genetics and the Search for Etiologies AN - 855899837; 201107828 AB - Continued progress in language and learning disabilities (LDs) research requires a renewed focused on issues of etiology. Genetics research forms a central tenet of such an agenda and is critical in clarifying relationships among oral language development, acquisition of literacy and mathematics, executive function skills, and comorbid conditions. For progress to be made, diversified efforts must continue to emphasize molecular and behavioral genetics (including quantitative genetics) approaches, in concert with multi-disciplinary and multi-modal projects, to provide an integrated understanding of the behavioral and biological manifestations of language and learning disabilities. Critically, increased efforts to include ethnic, socio-economic, and linguistically diverse participant samples across a range of developmental stages is required to meet the public health needs of learners in the US and across the world. Taken together, this body of work will continue to enhance our understanding of LDs and help us move toward a truly prevention based approach to language and learning disabilities. Adapted from the source document. JF - Behavior Genetics AU - Miller, Brett AU - McCardle, Peggy AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Suite 4B05, MSC 7510, Bethesda, MD, 20892, USA millerbre@mail.nih.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 1 EP - 5 PB - Springer Science+Business Media, Inc, New York, NY VL - 41 IS - 1 SN - 0001-8244, 0001-8244 KW - Socioeconomic factors KW - Language development KW - Learning disabilities KW - Aetiology KW - Mathematics KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855899837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavior+Genetics&rft.atitle=Moving+Closer+to+a+Public+Health+Model+of+Language+and+Learning+Disabilities%3A+The+Role+of+Genetics+and+the+Search+for+Etiologies&rft.au=Miller%2C+Brett%3BMcCardle%2C+Peggy&rft.aulast=Miller&rft.aufirst=Brett&rft.date=2011-01-01&rft.volume=41&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Behavior+Genetics&rft.issn=00018244&rft_id=info:doi/10.1007%2Fs10519-010-9439-9 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-03-07 N1 - Last updated - 2016-09-27 N1 - CODEN - BHGHAT N1 - SubjectsTermNotLitGenreText - Learning disabilities; Public health; Aetiology; Language development; Mathematics; Socioeconomic factors DO - http://dx.doi.org/10.1007/s10519-010-9439-9 ER - TY - JOUR T1 - In vivo efficacy of a chitosan/IL-12 adjuvant system for protein-based vaccines AN - 855677069; 14041309 AB - Vaccines based on recombinant proteins require adjuvant systems in order to generate Th1-type immune responses. We have developed a vaccine adjuvant system using a viscous chitosan solution and interleukin (IL)-12, a Th1-inducing cytokine. The chitosan solution is designed to create a depot of antigen and IL-12 at a subcutaneous injection site. We measured the in vivo immune response of a vaccine containing 0.25, 1, or 4aaI14g murine IL-12 and 75aaI14g ovalbumin (OVA), formulated in a 1.5% chitosan glutamate solution. The chitosan/IL-12/OVA vaccine, in comparison to chitosan/OVA, IL-12/OVA, or OVA alone, elicited greater antigen-specific CD4+ and CD8+ T-cell responses, as determined by CD4+ splenocyte proliferation, Th1 cytokine release, CD8+ T-cell interferon-I[sup3 release, and MHC class I peptide pentamer staining. The combination of chitosan and IL-12 also enhanced IgG2a and IgG2b antibody responses to OVA. Co-formulation of chitosan and IL-12 thus promoted the generation of a Th1 immune response to a model protein vaccine. JF - Biomaterials AU - Heffernan, Michael J AU - Zaharoff, David A AU - Fallon, Jonathan K AU - Schlom, Jeffrey AU - Greiner, John W AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 926 EP - 932 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 32 IS - 3 SN - 0142-9612, 0142-9612 KW - Biotechnology and Bioengineering Abstracts KW - Chitosan KW - Drug delivery KW - Immunostimulation KW - Interleukin-12 KW - Polysaccharide KW - Vaccine KW - Ovalbumin KW - Helper cells KW - Major histocompatibility complex KW - CD8 antigen KW - Adjuvants KW - Models KW - Interleukin 12 KW - Splenocytes KW - CD4 antigen KW - Antibodies KW - Immunoglobulin G KW - Lymphocytes T KW - chitosan KW - Glutamic acid KW - Immune response KW - Vaccines KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855677069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=In+vivo+efficacy+of+a+chitosan%2FIL-12+adjuvant+system+for+protein-based+vaccines&rft.au=Heffernan%2C+Michael+J%3BZaharoff%2C+David+A%3BFallon%2C+Jonathan+K%3BSchlom%2C+Jeffrey%3BGreiner%2C+John+W&rft.aulast=Heffernan&rft.aufirst=Michael&rft.date=2011-01-01&rft.volume=32&rft.issue=3&rft.spage=926&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=01429612&rft_id=info:doi/10.1016%2Fj.biomaterials.2010.09.058 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Ovalbumin; Helper cells; Major histocompatibility complex; Adjuvants; CD8 antigen; Models; Splenocytes; Interleukin 12; Antibodies; CD4 antigen; Lymphocytes T; Immunoglobulin G; chitosan; Vaccines; Immune response; Glutamic acid DO - http://dx.doi.org/10.1016/j.biomaterials.2010.09.058 ER - TY - JOUR T1 - Total body glutathione depletion induces oxidative stress and disrupts the immune function in mice AN - 853478427; 14063193 AB - The effect of total body glutathione (GSH) depletion induced by L-buthionine-(S,R)-sulfoximine (BSO) treatment on the murine immune system has not been studied previously. BSO was administered via drinking water for 14 days to induce total body GSH depletion. A significant decrease in total GSH (TGSH) of the immune organs such as spleen, liver, peritoneal macrophages as well as blood was observed. The proliferative response of splenocytes against different types of mitogens was significantly decreased in GSH-depleted mice compared to controls. The expression of several antioxidant enzymes was studied in both treated and control mice. No significant change was seen in major antioxidant enzymes; manganese superoxide dismutase and catalase. However, the expression of heme oxygenase-1 was increased in both liver and spleen in BSO-treated mice. Total body GSH depletion also increased lipid peroxidation as demonstrated by higher levels of malondialdehyde in BSO-treated mice. All the above-mentioned changes were reversed to near normal 14 days post termination of BSO treatment. These results demonstrate that TGSH depletion induces oxidative stress and adversely affects the function of the murine immune system. JF - Toxicological and Environmental Chemistry AU - Abdalla, Maher Y AU - Hassan, Iman M AU - Mustafa, Noor H AU - Tahtamouni, Lubna H AU - Ahmad, Iman M AD - Department of Biological Sciences and Biotechnology, The Hashemite University, Zarqa, Jordan,Center for Cancer Research, National Cancer Institute, National Naval Medical Center, Bethesda, MD 20889, USA Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 157 EP - 170 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 93 IS - 1 SN - 0277-2248, 0277-2248 KW - Toxicology Abstracts; Immunology Abstracts KW - glutathion KW - reactive oxygen species KW - immune system KW - heme oxygenase-1 KW - Macrophages KW - Antioxidants KW - Glutathione KW - Peritoneum KW - Spleen KW - Enzymes KW - Heme oxygenase (decyclizing) KW - Catalase KW - Lipid peroxidation KW - Splenocytes KW - Blood KW - Oxidative stress KW - Superoxide dismutase KW - Liver KW - Mitogens KW - Immune response KW - Drinking water KW - Manganese KW - Malondialdehyde KW - X 24490:Other KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853478427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+and+Environmental+Chemistry&rft.atitle=Total+body+glutathione+depletion+induces+oxidative+stress+and+disrupts+the+immune+function+in+mice&rft.au=Abdalla%2C+Maher+Y%3BHassan%2C+Iman+M%3BMustafa%2C+Noor+H%3BTahtamouni%2C+Lubna+H%3BAhmad%2C+Iman+M&rft.aulast=Abdalla&rft.aufirst=Maher&rft.date=2011-01-01&rft.volume=93&rft.issue=1&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Toxicological+and+Environmental+Chemistry&rft.issn=02772248&rft_id=info:doi/10.1080%2F02772248.2010.494828 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Number of references - 37 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Macrophages; Antioxidants; Glutathione; Peritoneum; Enzymes; Spleen; Heme oxygenase (decyclizing); Lipid peroxidation; Catalase; Blood; Splenocytes; Superoxide dismutase; Oxidative stress; Liver; Mitogens; Immune response; Drinking water; Manganese; Malondialdehyde DO - http://dx.doi.org/10.1080/02772248.2010.494828 ER - TY - JOUR T1 - Verbal working memory of Korean-English bilinguals: An fMRI study AN - 853228119; llba-201022636 AB - This study investigated whether different brain areas are involved during working memory tasks related to first (L1) and second (L2) languages. Functional magnetic resonance imaging (fMRI) was performed on 24 bilingual native Korean speakers who acquired English as their L2 after the age of 12. Their L2 proficiency ranged from low to moderate. The images were acquired while the participants performed word recognition tasks in their L1 and L2. Different areas of activation were identified for Korean and English verbal working memory (KVWM and EVWM) tasks and more right hemisphere activation was found during L2 processing than during L1 processing. Direct comparison between activation during L1 and L2 processing revealed that additional hemisphere regions were recruited during the EVWM condition than during the KVWM condition, but no significantly greater activation occurred during the KVWM task than during the EVWM task. This pattern of results indicates that distinct brain areas are associated with L1 and L2 processing, and more diverse and right hemisphere areas are activated during L2 processing compared to L1 processing among low to moderately proficient late bilinguals. The activated areas during L2 processing relative to L1 processing were the left precuneus (BA 7), right superior parietal lobule (BA 7), left middle occipital gyrus (BA 19), and left cerebellum, suggesting that participants might rely more on visual cues and visual processing for word recoding and visual analysis during L2 processing than during L1 processing. It is also plausible that participants engaged in attention-based rehearsal during L2 processing. [Copyright Elsevier Ltd.] JF - Journal of Neurolinguistics AU - Kim, K K AU - Byun, E AU - Lee, S K AU - Gaillard, W D AU - Xu, B AU - Theodore, W H Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 1 EP - 13 VL - 24 IS - 1 SN - 0911-6044, 0911-6044 KW - *Bilingualism (08850) KW - *Korean (40950) KW - *Short Term Memory (78150) KW - *Language Processing (43550) KW - *Brain (09350) KW - *Functional Magnetic Resonance Imaging (fMRI) (26525) KW - *Word Recognition (98200) KW - *English (21900) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853228119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurolinguistics&rft.atitle=Verbal+working+memory+of+Korean-English+bilinguals%3A+An+fMRI+study&rft.au=Kim%2C+K+K%3BByun%2C+E%3BLee%2C+S+K%3BGaillard%2C+W+D%3BXu%2C+B%3BTheodore%2C+W+H&rft.aulast=Kim&rft.aufirst=K&rft.date=2011-01-01&rft.volume=24&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurolinguistics&rft.issn=09116044&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2010-12-01 N1 - Last updated - 2014-06-17 N1 - CODEN - JONEE8 N1 - SubjectsTermNotLitGenreText - *Short Term Memory (78150); *Bilingualism (08850); *Language Processing (43550); *Korean (40950); *English (21900); *Functional Magnetic Resonance Imaging (fMRI) (26525); *Brain (09350); *Word Recognition (98200) ER - TY - JOUR T1 - Food Sold in School Vending Machines Is Associated With Overall Student Dietary Intake AN - 853208819; 201106178 AB - Purpose To examine the association between food sold in school vending machines and the dietary behaviors of students. Methods The 2005-2006 U.S. Health Behavior in School-aged Children survey was administered to 6th to 10th graders and school administrators. Dietary intake in students was estimated with a brief food frequency measure. School administrators completed questions regarding food sold in vending machines. For each food intake behavior, a multilevel regression analysis modeled students (level 1) nested within schools (level 2), with the corresponding food sold in vending machines as the main predictor. Control variables included gender, grade, family affluence, and school poverty index. Analyses were conducted separately for 6th to 8th and 9th-10th grades. Results In all, 83% of the schools (152 schools; 5,930 students) had vending machines that primarily sold food of minimal nutritional values (soft drinks, chips, and sweets). In younger grades, availability of fruit and/or vegetables and chocolate and/or sweets was positively related to the corresponding food intake, with vending machine content and school poverty index providing an explanation for 70.6% of between-school variation in fruit and/or vegetable consumption and 71.7% in sweets consumption. Among the older grades, there was no significant effect of food available in vending machines on reported consumption of those food. Conclusion Vending machines are widely available in public schools in the United States. In younger grades, school vending machines were either positively or negatively related to the diets of the students, depending on what was sold in them. Schools are in a powerful position to influence the diets of children; therefore, attention to the food sold at school is necessary to try to improve their diets. [Copyright The Society for Adolescent Medicine; published by Elsevier Inc.] JF - Journal of Adolescent Health AU - Rovner, Alisha J AU - Nansel, Tonja R AU - Wang, Jing AU - Iannotti, Ronald J AD - Division of Epidemiology, Statistics and Prevention Research, Department of Health and Human Services, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 13 EP - 19 PB - Elsevier, New York NY VL - 48 IS - 1 SN - 1054-139X, 1054-139X KW - Schools Vending machines food of minimal nutritional value KW - Food consumption KW - Healthy food KW - Food KW - Vending machines KW - Fruit KW - Diet KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853208819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=Food+Sold+in+School+Vending+Machines+Is+Associated+With+Overall+Student+Dietary+Intake&rft.au=Rovner%2C+Alisha+J%3BNansel%2C+Tonja+R%3BWang%2C+Jing%3BIannotti%2C+Ronald+J&rft.aulast=Rovner&rft.aufirst=Alisha&rft.date=2011-01-01&rft.volume=48&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/10.1016%2Fj.jadohealth.2010.08.021 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-02-16 N1 - Last updated - 2016-09-27 N1 - CODEN - JAHCD9 N1 - SubjectsTermNotLitGenreText - Vending machines; Food consumption; Healthy food; Food; Diet; Fruit DO - http://dx.doi.org/10.1016/j.jadohealth.2010.08.021 ER - TY - JOUR T1 - Counting dementia: There is no one 'best' way AN - 853208369; 201105704 AB - The growing societal and individual burden of dementia means that counting the cases of dementia is critical. There are several approaches and methods that can be used to identify dementia cases. The ascertainment can range from very detailed characterization of the individual (deep) to a brief standardized assessment (wide) that emphasizes individual functioning. The choice of going deep or wide depends on the goal of the ascertainment. These goals are discussed, as well as the emerging issues that may change the way dementia cases are classified. [Copyright Elsevier B.V.] JF - Alzheimer's & Dementia AU - Launer, Lenore J AD - Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA launerl@nia.nih.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 10 EP - 14 PB - Elsevier Ltd, The Netherlands VL - 7 IS - 1 SN - 1552-5260, 1552-5260 KW - Dementia Prevalence Case ascertainment KW - Assessment KW - Goals KW - Counting KW - Dementia KW - Burden KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853208369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alzheimer%27s+%26+Dementia&rft.atitle=Counting+dementia%3A+There+is+no+one+%27best%27+way&rft.au=Launer%2C+Lenore+J&rft.aulast=Launer&rft.aufirst=Lenore&rft.date=2011-01-01&rft.volume=7&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Alzheimer%27s+%26+Dementia&rft.issn=15525260&rft_id=info:doi/10.1016%2Fj.jalz.2010.11.003 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-02-16 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Dementia; Goals; Counting; Assessment; Burden DO - http://dx.doi.org/10.1016/j.jalz.2010.11.003 ER - TY - JOUR T1 - Strengthening the Public Research Agenda for Social Determinants of Health AN - 853207746; 201104984 AB - As the nation's health research agency, the mission of the NIH is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce the burdens of illness and disability. In addition to improving our understanding of the biological bases of health and disease, NIH-supported research demonstrates the compelling influence of social determinants on health outcomes. Across the life span, social and environmental contexts can affect rates of incidence, prevalence, mortality, and burden of diseases. Reports from the Institute of Medicine (IOM), WHO Commission to Build a Healthier America agree that social determinants are not only contributing factors for risk and resilience for health, but are important considerations for interventions beyond the individual to macro levels including neighborhoods, communities, and public policy. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Boyce, Cheryl Anne AU - Olster, Deborah H AD - National Institute on Drug Abuse, NIH, USDHHS, Bethesda, Maryland cboyce@mail.nih.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - S86 EP - S88 PB - Elsevier Science, New York NY VL - 40 SN - 0749-3797, 0749-3797 KW - Medical research KW - Life span KW - Health KW - Public policy KW - Burden KW - Prevalence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853207746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Strengthening+the+Public+Research+Agenda+for+Social+Determinants+of+Health&rft.au=Boyce%2C+Cheryl+Anne%3BOlster%2C+Deborah+H&rft.aulast=Boyce&rft.aufirst=Cheryl&rft.date=2011-01-01&rft.volume=40&rft.issue=&rft.spage=S86&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2010.10.006 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-02-16 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Health; Medical research; Burden; Prevalence; Public policy; Life span DO - http://dx.doi.org/10.1016/j.amepre.2010.10.006 ER - TY - JOUR T1 - A Linkage Map of the Asian Tiger Mosquito (Aedes albopictus) Based on cDNA Markers AN - 851472931; 14087362 AB - The Asian tiger mosquito, Aedes (Stegomyia) albopictus (Skuse), is an important vector of a number of arboviruses, and populations exhibit extreme variation in adaptive traits such as egg diapause, cold hardiness, and autogeny (ability to mature a batch of eggs without blood feeding). The genetic basis of some of these traits has been established, but lack of a high-resolution linkage map has prevented in-depth genetic analyses of the genes underlying these complex traits. We report here on the breeding of 4 F sub(1) intercross mapping families and the use of these to locate 35 cDNA markers to the A. albopictus linkage map. The present study increases the number of markers on the A. albopictus cDNA linkage map from 38 to 73 and the density of markers from 1 marker/5.7 cM to 1 marker/2.9 cM and adds 9, 16, and 10 markers to the 3 linkage groups, respectively. The overall lengths of the 3 linkage groups are 64.5, 76.5, and 71.6 cM, respectively, for a combined length of 212.6 cM. Despite conservation in the order of most genes among the 4 families and a previous mapping family, we found substantial heterogeneity in the amount of recombination among markers. This was most marked in linkage group I, which varied between 16.7 and 69.3 cM. A map integrating the results from these 4 families with an earlier cDNA linkage map is presented. JF - Journal of Heredity AU - Sutherland, Ian W AU - Mori, Akio AU - Montgomery, John AU - Fleming, Karen L AU - Anderson, Jennifer M AU - Valenzuela, Jesus G AU - Severson, David W AU - Black, William C, IV AD - From the Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 (Sutherland, Montgomery, Fleming, and Black); the Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556-5645 (Mori and Severson); and the Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 (Anderson and Valenzuela), wcb4@lamar.colostate.edu Y1 - 2011 PY - 2011 DA - 2011 SP - 102 EP - 112 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 1 SN - 0022-1503, 0022-1503 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Entomology Abstracts; Genetics Abstracts KW - Aedes albopictus KW - cDNA markers KW - linkage map KW - SSCP analysis KW - Feeding KW - Genetic analysis KW - Vectors KW - Hosts KW - Eggs KW - Autogeny KW - Public health KW - Disease transmission KW - Blood KW - Recombination KW - Genetics KW - Cold hardiness KW - Breeding KW - DNA KW - Conservation KW - Diapause KW - Aquatic insects KW - Gene mapping KW - Q1 08484:Species interactions: parasites and diseases KW - Z 05360:Genetics and Evolution KW - G 07750:Ecological & Population Genetics KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/851472931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Heredity&rft.atitle=A+Linkage+Map+of+the+Asian+Tiger+Mosquito+%28Aedes+albopictus%29+Based+on+cDNA+Markers&rft.au=Sutherland%2C+Ian+W%3BMori%2C+Akio%3BMontgomery%2C+John%3BFleming%2C+Karen+L%3BAnderson%2C+Jennifer+M%3BValenzuela%2C+Jesus+G%3BSeverson%2C+David+W%3BBlack%2C+William+C%2C+IV&rft.aulast=Sutherland&rft.aufirst=Ian&rft.date=2011-01-01&rft.volume=102&rft.issue=1&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Journal+of+Heredity&rft.issn=00221503&rft_id=info:doi/10.1093%2Fjhered%2Fesq105 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Genetics; Recombination; DNA; Hosts; Diapause; Aquatic insects; Disease transmission; Public health; Blood; Feeding; Cold hardiness; Breeding; Genetic analysis; Conservation; Vectors; Eggs; Autogeny; Gene mapping; Aedes albopictus DO - http://dx.doi.org/10.1093/jhered/esq105 ER - TY - JOUR T1 - Structural models of TREK channels and their gating mechanism. AN - 851226435; 21084863 AB - Mechanosensitive TREK channels belong to the family of K2P channels, a family of widely distributed, well modulated channels that uniquely have two similar or identical subunits, each with two TM1-P-TM2 motifs. Our goal is to build viable structural models of TREK channels, as representatives of K2P channels family. The structures available to be used as templates belong to the 2TM channels superfamily. These have low sequence similarity and different structural features: four symmetrically arranged subunits, each having one TM1-P-TM2 motif. Our model building strategy used two subunits of the template (KcsA) to build one subunit of the target (TREK-1). Our models of the Closed channel were adjusted to differ substantially from those of the template, e.g., TM2 of the 2nd repeat is near the axis of the pore whereas TM2 of the 1st repeat is far from the axis. Segments linking the two repeats and immediately following the last TM segment were modeled ab initio as α-helices based on helical periodicities of hydrophobic and hydrophilic residues, highly conserved and poorly conserved residues, and statistically related positions from multiple sequence alignments. The models were further refined by two-fold symmetry-constrained MD simulations using a protocol we developed previously. We also built models of the Open state and suggest a possible tension-activated gating mechanism characterized by helical motion with two-fold symmetry. Our models are consistent with deletion/truncation mutagenesis and thermodynamic analysis of gating described in the accompanying paper. JF - Channels (Austin, Tex.) AU - Milac, Adina AU - Anishkin, Andriy AU - Fatakia, Sarosh N AU - Chow, Carson C AU - Sukharev, Sergei AU - Guy, H Robert AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. PY - 2011 SP - 23 EP - 33 VL - 5 IS - 1 KW - Potassium Channels, Tandem Pore Domain KW - 0 KW - Protein Subunits KW - potassium channel protein TREK-1 KW - Index Medicus KW - Hydrophobic and Hydrophilic Interactions KW - Computer Simulation KW - Models, Molecular KW - Databases, Protein KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Structure-Activity Relationship KW - Protein Conformation KW - Ion Channel Gating KW - Potassium Channels, Tandem Pore Domain -- chemistry KW - Potassium Channels, Tandem Pore Domain -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/851226435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Channels+%28Austin%2C+Tex.%29&rft.atitle=Structural+models+of+TREK+channels+and+their+gating+mechanism.&rft.au=Milac%2C+Adina%3BAnishkin%2C+Andriy%3BFatakia%2C+Sarosh+N%3BChow%2C+Carson+C%3BSukharev%2C+Sergei%3BGuy%2C+H+Robert&rft.aulast=Milac&rft.aufirst=Adina&rft.date=2011-01-01&rft.volume=5&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Channels+%28Austin%2C+Tex.%29&rft.issn=1933-6969&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-27 N1 - Date created - 2011-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Pharmacol Sci. 2008 Nov;29(11):566-75 [18823665] Protein Sci. 2004 Jan;13(1):211-20 [14691236] Biophys J. 2004 Jun;86(6):3496-509 [15189849] PLoS One. 2009;4(3):e4681 [19262747] Proteins. 2010 Mar;78(4):932-49 [19902533] Nucleic Acids Res. 2010 Jul;38(Web Server issue):W545-9 [20457744] Protein Sci. 2000 Jun;9(6):1162-76 [10892809] J Biol Chem. 2000 Sep 15;275(37):28398-405 [10880510] Protein Sci. 2000 Sep;9(9):1753-73 [11045621] Am J Physiol Renal Physiol. 2000 Nov;279(5):F793-801 [11053038] Nature. 2001 Feb 8;409(6821):720-4 [11217861] Brain Res Mol Brain Res. 2001 Jan 31;86(1-2):101-14 [11165377] Nat Rev Neurosci. 2001 Mar;2(3):175-84 [11256078] Neuroscience. 2001;103(4):899-919 [11301200] Trends Neurosci. 2001 Jun;24(6):339-46 [11356506] EMBO J. 2000 Apr 17;19(8):1784-93 [10775263] Mol Pharmacol. 2000 May;57(5):906-12 [10779373] Mol Genet Metab. 2000 May;70(1):69-74 [10833333] EMBO J. 2000 Jun 1;19(11):2483-91 [10835347] J Biol Chem. 2000 Jun 9;275(23):17412-9 [10747911] J Biol Chem. 2001 Mar 9;276(10):7302-11 [11060316] J Neurosci. 2001 Oct 1;21(19):7491-505 [11567039] Nature. 2001 Nov 1;414(6859):43-8 [11689936] Biochem Biophys Res Commun. 2002 Mar 29;292(2):339-46 [11906167] Biochim Biophys Acta. 2002 Oct 11;1565(2):246-66 [12409199] Biochim Biophys Acta. 2002 Nov 13;1566(1-2):152-61 [12421546] J Gen Physiol. 2003 Mar;121(3):227-44 [12601086] Biochemistry. 2003 Aug 12;42(31):9263-8 [12899612] J Comput Chem. 2004 Oct;25(13):1584-604 [15264253] J Am Chem Soc. 2004 Aug 25;126(33):10478-84 [15315464] Biophys J. 2004 Oct;87(4):2255-70 [15454428] Trends Pharmacol Sci. 2004 Nov;25(11):601-8 [15491783] Biophys J. 1985 Jan;47(1):61-70 [3978191] J Mol Biol. 1990 Oct 5;215(3):403-10 [2231712] J Mol Biol. 1993 Dec 5;234(3):779-815 [8254673] Biophys J. 1993 Dec;65(6):2455-60 [7508762] Membr Biochem. 1978;2(1):1-16 [45776] J Mol Graph. 1996 Feb;14(1):33-8, 27-8 [8744570] Proteins. 1995 Dec;23(4):566-79 [8749853] Proteins. 1996 Oct;26(2):134-45 [8916221] Nucleic Acids Res. 1997 Sep 1;25(17):3389-402 [9254694] EMBO J. 1998 Aug 3;17(15):4283-90 [9687497] J Biol Chem. 1999 Sep 17;274(38):26691-6 [10480871] J Mol Biol. 1999 Sep 17;292(2):195-202 [10493868] Nucleic Acids Res. 2005 Jan 1;33(Database issue):D501-4 [15608248] Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17873-8 [15583130] J Biol Chem. 2005 Feb 11;280(6):4415-21 [15572365] J Physiol. 2005 Apr 1;564(Pt 1):103-16 [15677687] Bioinformatics. 2005 Apr 15;21(8):1719-20 [15585524] Proteins. 2005 May 15;59(3):467-75 [15768403] Science. 2005 Aug 5;309(5736):897-903 [16002581] J Comput Chem. 2005 Dec;26(16):1781-802 [16222654] Biophys J. 2006 Feb 15;90(4):L36-8 [16361340] Curr Opin Struct Biol. 2006 Apr;16(2):172-7 [16510277] J Membr Biol. 2005 Dec;208(3):193-202 [16604469] Nat Struct Mol Biol. 2006 Apr;13(4):311-8 [16532009] Chem Phys Lipids. 2006 Jun;141(1-2):83-93 [16620800] EMBO J. 2006 Jun 7;25(11):2368-76 [16675954] Curr Protein Pept Sci. 2006 Jun;7(3):217-27 [16787261] Nat Neurosci. 2006 Sep;9(9):1134-41 [16906152] Biophys J. 2006 Sep 15;91(6):L72-4 [16844753] Nat Rev Neurosci. 2007 Apr;8(4):251-61 [17375039] Brain Res. 2007 May 4;1144:1-18 [17324383] Proteins. 2007 Jun 1;67(4):922-30 [17373704] Cell Biochem Biophys. 2007;47(2):209-56 [17652773] Bioinformatics. 2007 Nov 1;23(21):2947-8 [17846036] Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W197-201 [18463136] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Detecting reactive oxygen species in primary hepatocytes treated with nanoparticles. AN - 822543901; 21116966 AB - This chapter describes a protocol for testing nanoparticle formulations for reactive oxygen species generation in male Sprague-Dawley (SD) primary hepatocytes. The protocol utilizes the fluorescent redox active probe, dichlorofluorescein diacetate (DCFH-DA). Primary hepatocytes were chosen for this assay since they have greater metabolic activity than hepatocyte cell lines. This method extends previous standardized cytotoxicity methods for particulates by evaluating mechanisms of toxicity in potential target organ cells. Oxidative stress has been identified as a likely mechanism of nanoparticle toxicity, and cell-based in vitro systems for evaluation of nanoparticle-induced oxidative stress are widely considered an important component of biocompatibility screens. JF - Methods in molecular biology (Clifton, N.J.) AU - Zolnik, Banu AU - Potter, Timothy M AU - Stern, Stephan T AD - Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD, USA. Y1 - 2011 PY - 2011 DA - 2011 SP - 173 EP - 179 VL - 697 KW - Fluoresceins KW - 0 KW - Fluorescent Dyes KW - Reactive Oxygen Species KW - diacetyldichlorofluorescein KW - 2044-85-1 KW - Index Medicus KW - Rats KW - Oxidation-Reduction KW - Fluorescent Dyes -- analysis KW - Animals KW - Rats, Sprague-Dawley KW - Microspectrophotometry -- methods KW - Fluorescent Dyes -- metabolism KW - Fluoresceins -- analysis KW - Fluoresceins -- metabolism KW - Cells, Cultured KW - Microspectrophotometry -- instrumentation KW - Male KW - Reactive Oxygen Species -- metabolism KW - Hepatocytes -- drug effects KW - Oxidative Stress -- drug effects KW - Nanoparticles -- toxicity KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822543901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Detecting+reactive+oxygen+species+in+primary+hepatocytes+treated+with+nanoparticles.&rft.au=Zolnik%2C+Banu%3BPotter%2C+Timothy+M%3BStern%2C+Stephan+T&rft.aulast=Zolnik&rft.aufirst=Banu&rft.date=2011-01-01&rft.volume=697&rft.issue=&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=1940-6029&rft_id=info:doi/10.1007%2F978-1-60327-198-1_18 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-13 N1 - Date created - 2010-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-60327-198-1_18 ER - TY - JOUR T1 - Prospective analysis of DNA damage and repair markers of lung cancer risk from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. AN - 821596339; 20929901 AB - Mutagen challenge and DNA repair assays have been used in case-control studies for nearly three decades to assess human cancer risk. The findings still engender controversy because blood was drawn after cancer diagnosis so the results may be biased, a type called 'reverse causation'. We therefore used Epstein-Barr virus-transformed lymphoblastoid cell lines established from prospectively collected peripheral blood samples to evaluate lung cancer risk in relation to three DNA repair assays: alkaline Comet assay, host cell reactivation (HCR) assay with the mutagen benzo[a]pyrene diol epoxide and the bleomycin mutagen sensitivity assay. Cases (n = 117) were diagnosed with lung cancer between 0.3 and 6 years after blood collection and controls (n = 117) were frequency matched on calendar year and age at blood collection, gender and smoking history; all races were included. Case and control status was unknown to laboratory investigators. In unconditional logistic regression analyses, statistically significantly increased lung cancer odds ratios (OR(adjusted)) were observed for bleomycin mutagen sensitivity as quartiles of chromatid breaks/cell [relative to the lowest quartile, OR = 1.2, 95% confidence interval (CI): 0.5-2.5; OR = 1.4, 95% CI: 0.7-3.1; OR = 2.1, 95% CI: 1.0-4.4, respectively, P(trend) = 0.04]. The magnitude of the association between the bleomycin assay and lung cancer risk was modest compared with those reported in previous lung cancer studies but was strengthened when we included only incident cases diagnosed more than a year after blood collection (P(trend) = 0.02), supporting the notion the assay may be a measure of cancer susceptibility. The Comet and HCR assays were unrelated to lung cancer risk. JF - Carcinogenesis AU - Sigurdson, Alice J AU - Jones, Irene M AU - Wei, Qingyi AU - Wu, Xifeng AU - Spitz, Margaret R AU - Stram, Douglas A AU - Gross, Myron D AU - Huang, Wen-Yi AU - Wang, Li-E AU - Gu, Jian AU - Thomas, Cynthia B AU - Reding, Douglas J AU - Hayes, Richard B AU - Caporaso, Neil E AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. sigurdsa@mail.nih.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 69 EP - 73 VL - 32 IS - 1 KW - Antibiotics, Antineoplastic KW - 0 KW - Biomarkers, Tumor KW - Bleomycin KW - 11056-06-7 KW - Index Medicus KW - Comet Assay KW - Randomized Controlled Trials as Topic KW - Mutagenicity Tests KW - Risk Factors KW - Humans KW - Aged KW - Middle Aged KW - Cell Line, Tumor KW - Male KW - Female KW - DNA Repair -- genetics KW - Biomarkers, Tumor -- genetics KW - Lung Neoplasms -- genetics KW - Genetic Predisposition to Disease KW - DNA Damage -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821596339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Prospective+analysis+of+DNA+damage+and+repair+markers+of+lung+cancer+risk+from+the+Prostate%2C+Lung%2C+Colorectal+and+Ovarian+%28PLCO%29+Cancer+Screening+Trial.&rft.au=Sigurdson%2C+Alice+J%3BJones%2C+Irene+M%3BWei%2C+Qingyi%3BWu%2C+Xifeng%3BSpitz%2C+Margaret+R%3BStram%2C+Douglas+A%3BGross%2C+Myron+D%3BHuang%2C+Wen-Yi%3BWang%2C+Li-E%3BGu%2C+Jian%3BThomas%2C+Cynthia+B%3BReding%2C+Douglas+J%3BHayes%2C+Richard+B%3BCaporaso%2C+Neil+E&rft.aulast=Sigurdson&rft.aufirst=Alice&rft.date=2011-01-01&rft.volume=32&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgq204 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-27 N1 - Date created - 2010-12-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Lett. 2001 May 26;166(2):155-63 [11311488] Crit Rev Oncol Hematol. 2001 Feb;37(2):87-96 [11166582] Environ Mol Mutagen. 2002;40(2):79-84 [12203399] Mutat Res. 2002 Nov 30;509(1-2):165-74 [12427537] Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1496-8 [12433734] Mutagenesis. 2002 Nov;17(6):489-93 [12435846] Mutat Res. 2003 May 15;526(1-2):93-125 [12714187] Cancer Epidemiol Biomarkers Prev. 2003 Aug;12(8):689-98 [12917198] J Natl Cancer Inst. 2003 Sep 3;95(17):1263-5 [12953074] Mutagenesis. 2004 Jul;19(4):285-90 [15215327] Hereditas. 1983;98(1):1-9 [6303985] Proc Natl Acad Sci U S A. 1983 Sep;80(18):5612-6 [6577447] Proc Natl Acad Sci U S A. 1985 Aug;82(16):5400-3 [3860870] Exp Cell Res. 1988 Mar;175(1):184-91 [3345800] Int J Cancer. 1989 Mar 15;43(3):403-9 [2466800] In Vitro Cell Dev Biol. 1990 Jan;26(1):80-4 [1689712] Cancer Res. 1991 Nov 1;51(21):5786-93 [1933849] Cancer Epidemiol Biomarkers Prev. 1996 Mar;5(3):191-7 [8833619] Cancer Epidemiol Biomarkers Prev. 1996 Mar;5(3):199-204 [8833620] Cancer Epidemiol Biomarkers Prev. 1999 Jun;8(6):567-77 [10385149] Mutat Res. 2005 Oct 3;586(2):173-88 [16099702] Mutat Res. 2005 Dec 30;592(1-2):147-54 [16054167] Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1935-40 [17035402] Cancer Res. 2007 Apr 15;67(8):3493-5 [17440053] Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):990-4 [18398043] Cancer Lett. 2008 Jul 18;266(1):60-72 [18374480] J Clin Oncol. 2008 Jul 20;26(21):3560-6 [18640936] Int J Cancer. 2009 Mar 1;124(5):999-1007 [19065660] Mutat Res. 2010 Feb 3;684(1-2):98-105 [20035771] J Natl Cancer Inst. 2000 Jun 7;92(11):874-97 [10841823] J Natl Cancer Inst. 2000 Nov 1;92(21):1764-72 [11058619] Mutagenesis. 2001 Jan;16(1):25-30 [11139596] Control Clin Trials. 2000 Dec;21(6 Suppl):251S-272S [11189683] Mutagenesis. 2002 May;17(3):211-4 [11971991] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgq204 ER - TY - JOUR T1 - Malformation syndromes caused by disorders of cholesterol synthesis. AN - 821191218; 20929975 AB - Cholesterol homeostasis is critical for normal growth and development. In addition to being a major membrane lipid, cholesterol has multiple biological functions. These roles include being a precursor molecule for the synthesis of steroid hormones, neuroactive steroids, oxysterols, and bile acids. Cholesterol is also essential for the proper maturation and signaling of hedgehog proteins, and thus cholesterol is critical for embryonic development. After birth, most tissues can obtain cholesterol from either endogenous synthesis or exogenous dietary sources, but prior to birth, the human fetal tissues are dependent on endogenous synthesis. Due to the blood-brain barrier, brain tissue cannot utilize dietary or peripherally produced cholesterol. Generally, inborn errors of cholesterol synthesis lead to both a deficiency of cholesterol and increased levels of potentially bioactive or toxic precursor sterols. Over the past couple of decades, a number of human malformation syndromes have been shown to be due to inborn errors of cholesterol synthesis. Herein, we will review clinical and basic science aspects of Smith-Lemli-Opitz syndrome, desmosterolosis, lathosterolosis, HEM dysplasia, X-linked dominant chondrodysplasia punctata, Congenital Hemidysplasia with Ichthyosiform erythroderma and Limb Defects Syndrome, sterol-C-4 methyloxidase-like deficiency, and Antley-Bixler syndrome. JF - Journal of lipid research AU - Porter, Forbes D AU - Herman, Gail E AD - Program in Developmental Genetics and Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. fdporter@mail.nih.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 6 EP - 34 VL - 52 IS - 1 KW - Cholesterol KW - 97C5T2UQ7J KW - Oxidoreductases Acting on CH-CH Group Donors KW - EC 1.3.- KW - Index Medicus KW - Smith-Lemli-Opitz Syndrome -- metabolism KW - Abnormalities, Multiple -- genetics KW - Animals KW - Oxidoreductases Acting on CH-CH Group Donors -- genetics KW - Humans KW - Smith-Lemli-Opitz Syndrome -- genetics KW - Abnormalities, Multiple -- etiology KW - Oxidoreductases Acting on CH-CH Group Donors -- metabolism KW - Chondrodysplasia Punctata -- genetics KW - Chondrodysplasia Punctata -- etiology KW - Smith-Lemli-Opitz Syndrome -- etiology KW - Syndrome KW - Abnormalities, Multiple -- metabolism KW - Oxidoreductases Acting on CH-CH Group Donors -- deficiency KW - Steroid Metabolism, Inborn Errors KW - Chondrodysplasia Punctata -- metabolism KW - Cholesterol -- biosynthesis KW - Lipid Metabolism, Inborn Errors -- etiology KW - Lipid Metabolism, Inborn Errors -- complications KW - Congenital Abnormalities -- etiology KW - Lipid Metabolism, Inborn Errors -- genetics KW - Lipid Metabolism, Inborn Errors -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821191218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+lipid+research&rft.atitle=Malformation+syndromes+caused+by+disorders+of+cholesterol+synthesis.&rft.au=Porter%2C+Forbes+D%3BHerman%2C+Gail+E&rft.aulast=Porter&rft.aufirst=Forbes&rft.date=2011-01-01&rft.volume=52&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Journal+of+lipid+research&rft.issn=1539-7262&rft_id=info:doi/10.1194%2Fjlr.R009548 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-21 N1 - Date created - 2010-12-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2191-7 [17761942] Am J Med Genet A. 2007 Oct 15;143A(20):2371-81 [17853487] Biochem Biophys Res Commun. 2007 Nov 23;363(3):800-5 [17904101] Am J Med Genet A. 2008 Jan 15;146A(2):208-11 [18076100] Mol Cell Biol. 2008 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- 2017-01-18 DO - http://dx.doi.org/10.1194/jlr.R009548 ER - TY - JOUR T1 - Carbohydrates contribute to the interactions between cockroach allergen Bla g 2 and a monoclonal antibody. AN - 820790773; 21123808 AB - The crystal structure of a murine mAb, 4C3, that binds to the C-terminal lobe of the cockroach allergen Bla g 2 has been solved at 1.8 Å resolution. Binding of 4C3 involves different types of molecular interactions with its epitope compared with those with the mAb 7C11, which binds to the N-terminal lobe of Bla g 2. We found that the 4C3 surface epitope on Bla g 2 includes a carbohydrate moiety attached to Asn(268) and that a large number of Ag-Ab contacts are mediated by water molecules and ions, most likely zinc. Ab binding experiments conducted with an enzymatically deglycosylated Bla g 2 and a N268Q mutant showed that the carbohydrate contributes, without being essential, to the Bla g 2-4C3 mAb interaction. Inhibition of IgE Ab binding by the mAb 4C3 shows a correlation of the structurally defined epitope with reactivity with human IgE. Site-directed mutagenesis of the 4C3 mAb epitope confirmed that the amino acids Lys(251), Glu(233), and Ile(199) are important for the recognition of Bla g 2 by the 4C3 mAb. The results show the relevance of x-ray crystallographic studies of allergen-Ab complexes to identify conformational epitopes that define the antigenic surface of Bla g 2. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Li, Mi AU - Gustchina, Alla AU - Glesner, Jill AU - Wünschmann, Sabina AU - Vailes, Lisa D AU - Chapman, Martin D AU - Pomés, Anna AU - Wlodawer, Alexander AD - Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD 21702, USA. Y1 - 2011/01/01/ PY - 2011 DA - 2011 Jan 01 SP - 333 EP - 340 VL - 186 IS - 1 KW - Allergens KW - 0 KW - Antibodies, Monoclonal KW - Aspartic Acid Endopeptidases KW - EC 3.4.23.- KW - allergen Bla g 2 KW - Acetylglucosamine KW - V956696549 KW - Abridged Index Medicus KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Antigen-Antibody Reactions KW - Animals KW - Mice KW - Crystallography, X-Ray KW - Glycosylation KW - Protein Binding -- immunology KW - Protein Conformation KW - Allergens -- chemistry KW - Aspartic Acid Endopeptidases -- genetics KW - Antibodies, Monoclonal -- metabolism KW - Allergens -- metabolism KW - Acetylglucosamine -- metabolism KW - Acetylglucosamine -- chemistry KW - Aspartic Acid Endopeptidases -- metabolism KW - Cockroaches -- immunology KW - Aspartic Acid Endopeptidases -- chemistry KW - Allergens -- genetics KW - Antibodies, Monoclonal -- chemistry KW - Acetylglucosamine -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/820790773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Carbohydrates+contribute+to+the+interactions+between+cockroach+allergen+Bla+g+2+and+a+monoclonal+antibody.&rft.au=Li%2C+Mi%3BGustchina%2C+Alla%3BGlesner%2C+Jill%3BW%C3%BCnschmann%2C+Sabina%3BVailes%2C+Lisa+D%3BChapman%2C+Martin+D%3BPom%C3%A9s%2C+Anna%3BWlodawer%2C+Alexander&rft.aulast=Li&rft.aufirst=Mi&rft.date=2011-01-01&rft.volume=186&rft.issue=1&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/10.4049%2Fjimmunol.1002318 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-27 N1 - Date created - 2010-12-21 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 3LIZ; PDB N1 - SuppNotes - Cited By: PLoS One. 2009;4(11):e7777 [19901987] Adv Protein Chem. 2002;61:119-60 [12461823] Science. 2003 Jun 27;300(5628):2065-71 [12829775] J Allergy Clin Immunol. 2004 Apr;113(4):776-82 [15100687] J Mol Biol. 2004 Jul 16;340(4):809-18 [15223322] Nature. 1978 Feb 16;271(5646):618-21 [24179] J Allergy Clin Immunol. 1989 May;83(5):875-82 [2715548] J Allergy Clin Immunol. 1991 Feb;87(2):505-10 [1993810] Glycobiology. 1992 Jun;2(3):233-40 [1379858] Am Rev Respir Dis. 1993 Mar;147(3):573-8 [8442589] Am J Respir Crit Care Med. 2002 Feb 1;165(3):391-7 [11818327] Genome Biol. 2002;3(4):REVIEWS3006 [11983066] Eur J Biochem. 2002 Jun;269(12):3086-92 [12071974] J Mol Biol. 1993 Dec 20;234(4):946-50 [8263940] Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6423-7 [7517550] J Biol Chem. 1995 Aug 18;270(33):19563-8 [7642642] Adv Protein Chem. 1996;49:57-133 [8908297] N Engl J Med. 1997 May 8;336(19):1356-63 [9134876] Eur J Biochem. 1997 Apr 15;245(2):334-9 [9151961] J Allergy Clin Immunol. 1997 Sep;100(3):327-34 [9314344] Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21 [9757107] Acta Crystallogr D Biol Crystallogr. 2002 Nov;58(Pt 11):1948-54 [12393927] Allergy. 1998;53(45 Suppl):54-7 [9788708] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] J Allergy Clin Immunol. 2005 Mar;115(3):478-85 [15753892] J Allergy Clin Immunol. 2005 Mar;115(3):555-63 [15753904] J Allergy Clin Immunol. 2005 Apr;115(4):803-9 [15806002] J Mol Biol. 2005 Apr 29;348(2):433-44 [15811379] J Allergy Clin Immunol. 2005 Jul;116(1):140-5 [15990787] Int Arch Allergy Immunol. 2007;142(2):99-115 [17033195] J Virol. 2007 Aug;81(15):8101-11 [17522218] J Allergy Clin Immunol. 2007 Nov;120(5):1126-31 [17825887] Int J Biol Macromol. 2008 Mar 1;42(2):185-90 [18249057] J Biol Chem. 2008 Aug 15;283(33):22806-14 [18519566] Science. 2009 Apr 10;324(5924):246-51 [19251591] Mol Immunol. 2009 Jun;46(10):2014-21 [19375166] J Allergy Clin Immunol. 2003 Apr;111(4):889-96 [12704374] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4049/jimmunol.1002318 ER - TY - JOUR T1 - Identification of clinically used drugs that activate pregnane X receptors. AN - 818642392; 20966043 AB - The pregnane X receptor (PXR) binds xenobiotics and regulates the expression of several drug-metabolizing enzymes and transporters. Human PXR (hPXR) activation and CYP3A4 induction can be involved in drug-drug interactions, resulting in reduced efficacy or increased toxicity. However, there are known species-specific differences with regard to PXR activation that should be taken into account when animal PXR data are extrapolated to humans. We profiled 2816 clinically used drugs from the National Institutes of Health Chemical Genomics Center Pharmaceutical Collection for their ability to activate hPXR and rat PXR (rPXR) at the cellular level, induce human CYP3A4 at the cellular level, and bind human PXR at the protein level. From 6 to 11% of drugs were identified as active across the four assays, which included assay-specific and pan-active compounds. The lowest concordance was observed between the hPXR and rPXR assays, and many compounds active in both assays nonetheless demonstrated significant potency differences between species. Analysis based on clustering potency values demonstrated the greatest activity correlation between the hPXR activation and CYP3A4 induction assays. Structure-activity relationship analysis identified chemical scaffolds that were pan-active (e.g., dihydropyridine calcium channel blockers) and others that were uniquely active in individual assays (e.g., steroids and fatty acids). These results provide important information on PXR activation by clinically used drugs, highlight the species specificity of PXR activation by xenobiotics, and provide a means of prioritizing compounds for follow-up studies and optimization efforts. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Shukla, Sunita J AU - Sakamuru, Srilatha AU - Huang, Ruili AU - Moeller, Timothy A AU - Shinn, Paul AU - Vanleer, Danielle AU - Auld, Douglas S AU - Austin, Christopher P AU - Xia, Menghang AD - National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 151 EP - 159 VL - 39 IS - 1 KW - Pharmaceutical Preparations KW - 0 KW - Receptors, Steroid KW - Small Molecule Libraries KW - Xenobiotics KW - pregnane X receptor KW - CYP3A4 protein, human KW - EC 1.14.13.67 KW - Cytochrome P-450 CYP3A KW - EC 1.14.14.1 KW - Index Medicus KW - Rats KW - Animals KW - Drug Interactions KW - Hep G2 Cells KW - Humans KW - Cell Line, Tumor KW - Species Specificity KW - Structure-Activity Relationship KW - Hepatocytes -- metabolism KW - Pharmaceutical Preparations -- metabolism KW - Xenobiotics -- metabolism KW - Cytochrome P-450 CYP3A -- metabolism KW - Receptors, Steroid -- metabolism KW - Receptors, Steroid -- agonists UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/818642392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=Identification+of+clinically+used+drugs+that+activate+pregnane+X+receptors.&rft.au=Shukla%2C+Sunita+J%3BSakamuru%2C+Srilatha%3BHuang%2C+Ruili%3BMoeller%2C+Timothy+A%3BShinn%2C+Paul%3BVanleer%2C+Danielle%3BAuld%2C+Douglas+S%3BAustin%2C+Christopher+P%3BXia%2C+Menghang&rft.aulast=Shukla&rft.aufirst=Sunita&rft.date=2011-01-01&rft.volume=39&rft.issue=1&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=1521-009X&rft_id=info:doi/10.1124%2Fdmd.110.035105 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-05 N1 - Date created - 2010-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Lett. 2010 Mar 1;193(1):120-3 [20035846] Nature. 2000 Jul 27;406(6794):435-9 [10935643] Curr Drug Metab. 2006 May;7(4):375-88 [16724927] Drug Metab Rev. 2006;38(3):515-97 [16877263] Arch Dermatol Res. 2006 Sep;298(4):191-9 [16868738] Steroids. 2007 Mar;72(3):231-46 [17284330] Cancer Treat Rev. 2007 Jun;33(4):369-80 [17451886] J Phys Chem B. 2008 Mar 13;112(10):3251-8 [18281977] BMC Evol Biol. 2008;8:103 [18384689] Int Ophthalmol. 2008 Aug;28(4):281-5 [17762913] Chem Res Toxicol. 2008 Jul;21(7):1457-67 [18547065] Drug Metab Dispos. 2008 Aug;36(8):1689-97 [18505790] AAPS J. 2008 Jun;10(2):391-400 [18686044] J Biol Chem. 2008 Nov 7;283(45):30650-7 [18784074] Pharmacogenomics. 2008 Nov;9(11):1695-709 [19018724] Drug Metab Lett. 2007 Apr;1(2):147-52 [19356035] Assay Drug Dev Technol. 2009 Apr;7(2):143-69 [19505231] Nat Biotechnol. 2009 Nov;27(11):1050-5 [19855396] Mol Endocrinol. 2000 Jan;14(1):27-39 [10628745] J Biol Chem. 2000 May 19;275(20):15122-7 [10748001] Mol Endocrinol. 2005 Jun;19(6):1429-38 [15914712] Chem Biol Interact. 2001 May 16;134(3):283-9 [11336976] Science. 2001 Jun 22;292(5525):2329-33 [11408620] Drug Metab Dispos. 2001 Oct;29(10):1325-31 [11560876] Annu Rev Pharmacol Toxicol. 2002;42:1-23 [11807162] Trends Pharmacol Sci. 2002 Feb;23(2):49-50 [11830254] Drug Metab Dispos. 2002 Jul;30(7):795-804 [12065438] J Pharmacol Exp Ther. 2002 Oct;303(1):412-23 [12235278] J Nutr. 2003 Jul;133(7 Suppl):2444S-2447S [12840222] Biol Pharm Bull. 2004 Mar;27(3):415-7 [14993813] Toxicology. 2004 Jun 1;199(1):23-33 [15125996] Hypertension. 1993 Jun;21(6 Pt 2):1020-3 [8505086] Toxicol Appl Pharmacol. 1993 Jun;120(2):298-307 [8511800] J Biol Chem. 1995 Jun 2;270(22):12953-6 [7768881] Drug Metab Dispos. 1995 Mar;23(3):415-21 [7628309] Mol Pharmacol. 1996 Jul;50(1):10-6 [8700101] Cell. 1998 Jan 9;92(1):73-82 [9489701] J Clin Invest. 1998 Sep 1;102(5):1016-23 [9727070] Genes Dev. 1998 Oct 15;12(20):3149-55 [9784489] Drug Metab Dispos. 2005 Jan;33(1):38-48 [15466163] Erratum In: Drug Metab Dispos. 2011 Feb;39(2):351 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/dmd.110.035105 ER - TY - JOUR T1 - A novel class of photo-triggerable liposomes containing DPPC:DC(8,9)PC as vehicles for delivery of doxorubcin to cells. AN - 816386137; 20691151 AB - Success of nanoparticle-mediated drug delivery is subject to development of optimal drug release strategies within defined space and time (triggered release). Recently, we reported a novel class of photo-triggerable liposomes prepared from dipalmitoyl phosphatidylcholine (DPPC) and photopolymerizable diacetylene phospholipid (DC(8),(9)PC), that efficiently released entrapped calcein (a water soluble fluorescent dye) upon UV (254nm) treatment. To develop these formulations for in vivo applications, we have examined phototriggering of these liposomes by visible light, and the effect of released anticancer drugs on cellular toxicity. Sonicated liposomes containing various ratios of DPPC:DC(8),(9)PC and 4mol% DSPE-PEG2000 were loaded with calcein (Ex/Em, 485/517nm) or a chemotherapy drug, Doxorubicin (DOX, Ex/Em 490/590nm). Our initial experiments showed that 514nm laser treatment of liposomes containing 10 or 20mol% DC(8,9)PC for 1-3min resulted in significant release of calcein. Based on these results, we performed studies with DOX-loaded liposomes. First, biophysical properties (including liposome size and stability) and DOX encapsulation efficiency of the liposomes were determined. Subsequently, the effect of 514nm laser on DOX release, and cellular toxicity by released DOX were examined. Since liposomes using the 86:10:04 mole ratio of DPPC:DC(8),(9)PC:DSPE-PEG2000, showed highest encapsulation of DOX, these formulations were investigated further. We report that (i) liposomes retained about 70% of entrapped DOX at 37°C in the presence of 0-50% serum. (ii) 514nm laser treatment resulted in DOX release from liposomes in a wavelength-specific manner. (iii) Laser treatment of co-cultures containing DOX-loaded liposomes and cells (Raji and MCF-7) resulted in at least 2-3 fold improved cell killing as compared to untreated samples. Taken together, the photo-triggerable liposomes described here may provide a platform for future drug delivery applications. To our knowledge, this is the first report demonstrating improved cell killing following light-triggered release of an encapsulated anticancer agent from photosensitive liposomes. Published by Elsevier B.V. JF - Biochimica et biophysica acta AU - Yavlovich, Amichai AU - Singh, Alok AU - Blumenthal, Robert AU - Puri, Anu AD - Membrane Structure and Function Section, Nanobiology Program, NCI-Frederick, Frederick, MD 21702, USA. Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 117 EP - 126 VL - 1808 IS - 1 SN - 0006-3002, 0006-3002 KW - Antineoplastic Agents KW - 0 KW - Drug Carriers KW - Fluorescent Dyes KW - Liposomes KW - Phosphatidylcholines KW - Water KW - 059QF0KO0R KW - 1,2-Dipalmitoylphosphatidylcholine KW - 2644-64-6 KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Drug Delivery Systems KW - Coculture Techniques KW - Antineoplastic Agents -- administration & dosage KW - Biophysics -- methods KW - Phosphatidylcholines -- chemistry KW - Humans KW - Water -- chemistry KW - Light KW - Lasers KW - Fluorescent Dyes -- chemistry KW - Cell Line, Tumor KW - Doxorubicin -- chemistry KW - Doxorubicin -- administration & dosage KW - 1,2-Dipalmitoylphosphatidylcholine -- chemistry KW - Liposomes -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/816386137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=A+novel+class+of+photo-triggerable+liposomes+containing+DPPC%3ADC%288%2C9%29PC+as+vehicles+for+delivery+of+doxorubcin+to+cells.&rft.au=Yavlovich%2C+Amichai%3BSingh%2C+Alok%3BBlumenthal%2C+Robert%3BPuri%2C+Anu&rft.aulast=Yavlovich&rft.aufirst=Amichai&rft.date=2011-01-01&rft.volume=1808&rft.issue=1&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbamem.2010.07.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-07 N1 - Date created - 2010-12-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: FEBS Lett. 2000 Feb 4;467(1):52-6 [10664455] Chem Commun (Camb). 2005 Jun 28;(24):3021-3 [15959571] Eur J Biochem. 2000 Sep;267(17):5585-92 [10951218] Biochem Biophys Res Commun. 2000 Sep 16;276(1):169-73 [11006101] Clin Cancer Res. 2001 Feb;7(2):223-5 [11234871] Adv Drug Deliv Rev. 2001 Dec 31;53(3):273-84 [11744172] Curr Drug Metab. 2001 Dec;2(4):397-409 [11766990] Virology. 2002 Feb 15;293(2):243-51 [11886244] Biophys J. 2002 Apr;82(4):2101-10 [11916866] J Control Release. 2002 May 17;81(1-2):7-23 [11992674] J Magn Reson Imaging. 2002 Oct;16(4):388-93 [12353254] Biosci Rep. 2002 Apr;22(2):197-224 [12428901] Nat Med. 2003 Jan;9(1):123-8 [12514725] Chem Phys Lipids. 2003 Jan;122(1-2):191-203 [12598052] Clin Pharmacokinet. 2003;42(5):419-36 [12739982] FEBS Lett. 1980 Mar 10;111(2):324-8 [7358175] Biochem Biophys Res Commun. 1981 Jul 16;101(1):131-6 [7283995] Biochem J. 1981 Oct 1;199(1):251-4 [7337706] Biotechnol Lett. 2007 Nov;29(11):1637-44 [17636387] J Liposome Res. 2008;18(4):293-307 [18937120] Photochem Photobiol. 2009 Jul-Aug;85(4):848-60 [19222790] J Photochem Photobiol B. 2009 Dec 2;97(3):138-44 [19811928] Photochem Photobiol. 2000 Jul;72(1):57-61 [10911729] Ukr Biokhim Zh (1978). 1984 May-Jun;56(3):339-45 [6464207] Chem Phys Lipids. 1988 Nov;49(1-2):39-47 [3233710] J Lipid Res. 1990 Aug;31(8):1522-5 [2280193] Biochim Biophys Acta. 1991 Nov 18;1070(1):187-92 [1751525] Biochim Biophys Acta. 1993 Sep 19;1151(2):201-15 [8373796] Cancer Chemother Pharmacol. 1994;35(1):17-20 [7987973] FEBS Lett. 1995 Nov 13;375(1-2):113-6 [7498457] J Biochem. 1997 Jan;121(1):15-9 [9058185] Cancer Chemother Pharmacol. 1997;40(2):138-42 [9182835] Oncology (Williston Park). 1999 Jul;13(7 Suppl 3):77-81 [10442369] J Biol Chem. 1960 Mar;235:769-75 [13793161] Nat Rev Drug Discov. 2005 Feb;4(2):145-60 [15688077] Prog Lipid Res. 2005 Jan;44(1):68-97 [15748655] Exp Mol Pathol. 2010 Apr;88(2):238-49 [20122924] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbamem.2010.07.030 ER - TY - JOUR T1 - Smoking during first pregnancy and breast cancer: a case-control study using Washington State registry data. AN - 816385955; 21130370 AB - To examine whether smoking during first pregnancy, a time of potential vulnerability to tobacco mutagens, is associated with breast cancer. We conducted a nested case-control study within a cohort of Washington State residents with first deliveries during 1984-1999, identified in birth and fetal death records. Linkage to population-based cancer registry data identified 1,099 women in the cohort aged 65 years and younger diagnosed with breast cancer in 1985-2000. Controls (N=10,922) were matched by year and age of first delivery, race/ethnicity, and birth outcome. Maternal smoking and other variables characterizing the pregnancy were obtained from birth and fetal death records. Conditional logistic regression was used to analyze the data. The adjusted risk ratio for breast cancer was 0.8, 95% confidence interval 0.7-0.9, among women who smoked during their pregnancy compared with similar women who did not smoke. When the sample was restricted to known state residents at the time of the matched case's diagnosis, there was no association (risk ratio 1.0; 0.8-1.1). Our results do not suggest that cigarette smoking during first pregnancy increases the risk of breast cancer. Published by Elsevier Inc. JF - Annals of epidemiology AU - DeRoo, Lisa A AU - Cummings, Peter AU - Daling, Janet R AU - Mueller, Beth A AD - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. DeRooL@niehs.nih.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 53 EP - 55 VL - 21 IS - 1 KW - Index Medicus KW - Risk KW - Washington -- epidemiology KW - Registries -- statistics & numerical data KW - Humans KW - Cohort Studies KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Female KW - Breast Neoplasms -- genetics KW - Smoking -- adverse effects KW - Pregnancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/816385955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+epidemiology&rft.atitle=Smoking+during+first+pregnancy+and+breast+cancer%3A+a+case-control+study+using+Washington+State+registry+data.&rft.au=DeRoo%2C+Lisa+A%3BCummings%2C+Peter%3BDaling%2C+Janet+R%3BMueller%2C+Beth+A&rft.aulast=DeRoo&rft.aufirst=Lisa&rft.date=2011-01-01&rft.volume=21&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Annals+of+epidemiology&rft.issn=1873-2585&rft_id=info:doi/10.1016%2Fj.annepidem.2010.09.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-04 N1 - Date created - 2010-12-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Public Health Rep. 2008 Sep-Oct;123(5):586-92 [18828413] Epidemiology. 1995 May;6(3):209-11 [7619924] Eur J Cancer Prev. 1993 Nov;2 Suppl 3:85-100 [7905315] Microsc Res Tech. 2001 Jan 15;52(2):204-23 [11169868] Cancer Causes Control. 2003 Jun;14(5):497-503 [12946045] Cancer Causes Control. 2001 Feb;12(2):179-85 [11246847] Am J Epidemiol. 1989 Jan;129(1):125-37 [2910056] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.annepidem.2010.09.004 ER - TY - JOUR T1 - SEM X-ray microanalysis of nanoparticles present in tissue or cultured cell thin sections. AN - 815556224; 21116957 AB - Energy Dispersive X-ray (EDX) microanalysis is a technique used for identification of the elemental composition of a specimen. The detection of nanoparticles in tissue is a common problem of biodistribution and toxicity studies. High-resolution transmission electron microscopy (TEM) can be employed to detect nanoparticles based on morphology; however, TEM alone cannot conclusively identify nanoparticles. Indeed, micrographs are often ambiguous due to particle aggregation, contamination, or morphology change after cellular uptake. EDX can be used to confirm the composition and distribution of the nanoparticles through spectrum and elemental mapping. This protocol outlines the procedures for compositional identification of nanoparticles using an EDX spectrometer incorporated into a scanning electron microscopy (SEM) system. This protocol outlines sample preparation, EDX spectrum acquisition, elemental peak analysis and spectral mapping acquisition. JF - Methods in molecular biology (Clifton, N.J.) AU - Zheng, Jiwen AU - Nagashima, Kunio AU - Parmiter, David AU - de la Cruz, Jason AU - Patri, Anil K AD - Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD, USA. Y1 - 2011 PY - 2011 DA - 2011 SP - 93 EP - 99 VL - 697 KW - Carbon KW - 7440-44-0 KW - Gold KW - 7440-57-5 KW - Titanium KW - D1JT611TNE KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Animals KW - Gold -- analysis KW - Macrophages -- chemistry KW - Spectrometry, X-Ray Emission KW - Electron Probe Microanalysis -- methods KW - Tissue Culture Techniques KW - Lung -- chemistry KW - Lung -- cytology KW - Carbon -- analysis KW - Carbon -- chemistry KW - Rodentia -- anatomy & histology KW - Microscopy, Electron, Transmission KW - Titanium -- chemistry KW - Titanium -- analysis KW - Cells, Cultured KW - Lung -- ultrastructure KW - Oxygen -- chemistry KW - Oxygen -- analysis KW - Macrophages -- ultrastructure KW - Gold -- chemistry KW - Nanoparticles -- analysis KW - Microtomy KW - Microscopy, Electron, Scanning -- methods KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815556224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=SEM+X-ray+microanalysis+of+nanoparticles+present+in+tissue+or+cultured+cell+thin+sections.&rft.au=Zheng%2C+Jiwen%3BNagashima%2C+Kunio%3BParmiter%2C+David%3Bde+la+Cruz%2C+Jason%3BPatri%2C+Anil+K&rft.aulast=Zheng&rft.aufirst=Jiwen&rft.date=2011-01-01&rft.volume=697&rft.issue=&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=1940-6029&rft_id=info:doi/10.1007%2F978-1-60327-198-1_9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-13 N1 - Date created - 2010-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-60327-198-1_9 ER - TY - JOUR T1 - Autophagy monitoring assay: qualitative analysis of MAP LC3-I to II conversion by immunoblot. AN - 815553159; 21116969 AB - Lysosomal dysfunction is a recognized toxic mechanism for xenobiotics, which can result in various pathological states. There is concern that nanoparticles, in particular, may cause lysosomal pathologies, since they are likely to accumulate within lysosomes. Dysregulation of the autophagy-lysosomal degradation pathway is an example of lysosomal dysfunction associated with exposure to some nanomaterials. Here, we present a method to monitor autophagy by measurement the autophagosome marker LC3-II, a phosphatidylethanolamine (PE)-conjugated form of microtubule-associated protein 1 light chain 3-I (MAP LC3-I). As other conditions could potentially result in LC3-II expression, treatment-related changes in expression should be further evaluated by morphological assessment, using techniques such as electron microscopy, to confirm autophagosome involvement. JF - Methods in molecular biology (Clifton, N.J.) AU - McLeland, Christopher B AU - Rodriguez, Jamie AU - Stern, Stephan T AD - Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD, USA. Y1 - 2011 PY - 2011 DA - 2011 SP - 199 EP - 206 VL - 697 KW - Biomarkers KW - 0 KW - Microtubule-Associated Proteins KW - Phosphatidylethanolamines KW - Index Medicus KW - Swine KW - Lysosomes -- physiology KW - Animals KW - Phosphatidylethanolamines -- metabolism KW - LLC-PK1 Cells KW - Biomarkers -- metabolism KW - Microscopy, Electron KW - Lysosomes -- metabolism KW - Light KW - Cell Line KW - Immunoblotting -- methods KW - Microtubule-Associated Proteins -- metabolism KW - Autophagy -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815553159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Autophagy+monitoring+assay%3A+qualitative+analysis+of+MAP+LC3-I+to+II+conversion+by+immunoblot.&rft.au=McLeland%2C+Christopher+B%3BRodriguez%2C+Jamie%3BStern%2C+Stephan+T&rft.aulast=McLeland&rft.aufirst=Christopher&rft.date=2011-01-01&rft.volume=697&rft.issue=&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=1940-6029&rft_id=info:doi/10.1007%2F978-1-60327-198-1_21 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-13 N1 - Date created - 2010-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-60327-198-1_21 ER - TY - JOUR T1 - Challenges for nanoparticle characterization. AN - 815553119; 21116950 AB - The Food and Drug Administration (FDA) and pharmaceutical industry have used standards to assess material biocompatibility, immunotoxicity, purity, and sterility (as well as many other properties) for several decades. Nanoparticle developers and manufacturers leverage well-established methods as much as possible. However, the unique properties of nanomaterials often interfere with standardized protocols, giving false-positive or false-negative results. This chapter provides details of some of the problems which can arise during the characterization of nanoparticle samples. Additionally, we discuss ways to identify, avoid, and resolve such interference, with emphasis on the use of inhibition and enhancement controls. JF - Methods in molecular biology (Clifton, N.J.) AU - McNeil, Scott E AD - Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD, USA. ncl@mail.nih.gov Y1 - 2011 PY - 2011 DA - 2011 SP - 9 EP - 15 VL - 697 KW - Drugs, Investigational KW - 0 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Nanostructures -- chemistry KW - Humans KW - Reference Standards KW - Drugs, Investigational -- chemistry KW - Drug Industry KW - Nanoparticles -- adverse effects KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815553119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Challenges+for+nanoparticle+characterization.&rft.au=McNeil%2C+Scott+E&rft.aulast=McNeil&rft.aufirst=Scott&rft.date=2011-01-01&rft.volume=697&rft.issue=&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=1940-6029&rft_id=info:doi/10.1007%2F978-1-60327-198-1_2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-13 N1 - Date created - 2010-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-60327-198-1_2 ER - TY - JOUR T1 - Evaluation of cytotoxicity of nanoparticulate materials in porcine kidney cells and human hepatocarcinoma cells. AN - 815552838; 21116964 AB - This chapter describes method for evaluation of nanomaterial cytotoxicity by examining effects on porcine kidney (LLC-PK1) and human cancerous liver cells (Hep G2). Several studies indicate that many nanoparticles are cleared from the body through the kidney or liver, making these organs good choices for target organ toxicity evaluation. In this standard, two separate metrics (MTT and LDH) provide complementary data, that can be used to identify interference. JF - Methods in molecular biology (Clifton, N.J.) AU - Potter, Timothy M AU - Stern, Stephan T AD - Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD, USA. Y1 - 2011 PY - 2011 DA - 2011 SP - 157 EP - 165 VL - 697 KW - Formazans KW - 0 KW - Tetrazolium Salts KW - MTT formazan KW - 23305-68-2 KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Index Medicus KW - Swine KW - Animals KW - Spectrometry, Fluorescence KW - Hep G2 Cells KW - Particle Size KW - Humans KW - LLC-PK1 Cells KW - Tetrazolium Salts -- analysis KW - Formazans -- analysis KW - Tetrazolium Salts -- metabolism KW - L-Lactate Dehydrogenase -- metabolism KW - Nanoparticles -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815552838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Evaluation+of+cytotoxicity+of+nanoparticulate+materials+in+porcine+kidney+cells+and+human+hepatocarcinoma+cells.&rft.au=Potter%2C+Timothy+M%3BStern%2C+Stephan+T&rft.aulast=Potter&rft.aufirst=Timothy&rft.date=2011-01-01&rft.volume=697&rft.issue=&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=1940-6029&rft_id=info:doi/10.1007%2F978-1-60327-198-1_16 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-13 N1 - Date created - 2010-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-60327-198-1_16 ER - TY - JOUR T1 - Assay to detect lipid peroxidation upon exposure to nanoparticles. AN - 815552750; 21116967 AB - This chapter describes a method for the analysis of human hepatocarcinoma cells (HEP G2) for lipid peroxidation products, such as malondialdehyde (MDA), following treatment with nanoparticle formulations. Oxidative stress has been identified as a likely mechanism of nanoparticle toxicity, and cell-based in vitro systems for evaluation of nanoparticle-induced oxidative stress are widely considered to be an important component of biocompatibility screens. The products of lipid peroxidation, lipid hydroperoxides, and aldehydes, such as MDA, can be measured via a thiobarbituric acid reactive substances (TBARS) assay. In this assay, which can be performed in cell culture or in cell lysate, MDA combines with thiobarbituric acid (TBA) to form a fluorescent adduct that can be detected at an excitation wavelength of 530 nm and an emission wavelength of 550 nm. The results are then expressed as MDA equivalents, normalized to total cellular protein (determined by Bradford assay). JF - Methods in molecular biology (Clifton, N.J.) AU - Potter, Timothy M AU - Neun, Barry W AU - Stern, Stephan T AD - Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD, USA. Y1 - 2011 PY - 2011 DA - 2011 SP - 181 EP - 189 VL - 697 KW - Aldehydes KW - 0 KW - Fluorescent Dyes KW - Lipid Peroxides KW - Proteins KW - Thiobarbituric Acid Reactive Substances KW - Malondialdehyde KW - 4Y8F71G49Q KW - Index Medicus KW - Fluorescent Dyes -- metabolism KW - Aldehydes -- analysis KW - Hep G2 Cells KW - Humans KW - Reference Standards KW - Oxidative Stress KW - Biological Assay KW - Proteins -- analysis KW - Proteins -- metabolism KW - Lipid Peroxides -- analysis KW - Thiobarbituric Acid Reactive Substances -- metabolism KW - Malondialdehyde -- metabolism KW - Thiobarbituric Acid Reactive Substances -- analysis KW - Malondialdehyde -- analysis KW - Nanoparticles -- toxicity KW - Lipid Peroxidation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815552750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomechanics&rft.atitle=Assessing+the+accuracy+and+precision+of+musculoskeletal+motion+tracking+using+cine-PC+MRI+on+a+3.0T+platform&rft.au=Behnam%2C+Abrahm+J%3BHerzka%2C+Daniel+A%3BSheehan%2C+Frances+T&rft.aulast=Behnam&rft.aufirst=Abrahm&rft.date=2011-01-04&rft.volume=44&rft.issue=1&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomechanics&rft.issn=00219290&rft_id=info:doi/10.1016%2Fj.jbiomech.2010.08.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-13 N1 - Date created - 2010-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-60327-198-1_19 ER - TY - JOUR T1 - Zeta potential measurement. AN - 815552606; 21116954 AB - This chapter describes a method for the measurement of the electrostatic potential at the electrical double layer surrounding a nanoparticle in solution. This is referred to as the zeta potential. Nanoparticles with a zeta potential between -10 and +10 mV are considered approximately neutral, while nanoparticles with zeta potentials of greater than +30 mV or less than -30 mV are considered strongly cationic and strongly anionic, respectively. Since most cellular membranes are negatively charged, zeta potential can affect a nanoparticle's tendency to permeate membranes, with cationic particles generally displaying more toxicity associated with cell wall disruption. This technique is demonstrated for two types of nanoparticles commonly used in biological applications: colloidal gold (strongly anionic) and amine-terminated PAMAM dendrimer (strongly cationic). JF - Methods in molecular biology (Clifton, N.J.) AU - Clogston, Jeffrey D AU - Patri, Anil K AD - Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD, USA. Y1 - 2011 PY - 2011 DA - 2011 SP - 63 EP - 70 VL - 697 KW - Anions KW - 0 KW - Cations KW - Colloids KW - Dendrimers KW - PAMAM Starburst KW - Water KW - 059QF0KO0R KW - Gold KW - 7440-57-5 KW - Index Medicus KW - Static Electricity KW - Osmolar Concentration KW - Colloids -- chemistry KW - Viscosity KW - Electric Conductivity KW - Hydrogen-Ion Concentration KW - Water -- chemistry KW - Temperature KW - Dendrimers -- chemistry KW - Gold -- chemistry KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815552606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Zeta+potential+measurement.&rft.au=Clogston%2C+Jeffrey+D%3BPatri%2C+Anil+K&rft.aulast=Clogston&rft.aufirst=Jeffrey&rft.date=2011-01-01&rft.volume=697&rft.issue=&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=1940-6029&rft_id=info:doi/10.1007%2F978-1-60327-198-1_6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-13 N1 - Date created - 2010-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-60327-198-1_6 ER - TY - JOUR T1 - Analysis of microbial contamination in nanoparticle formulations. AN - 815552402; 21116961 AB - This chapter describes a procedure for quantitative determination of microbial contamination of a nanoparticle formulation. The protocol includes tests for yeast, mold, and bacteria using Millipore sampler devices. This approach is primarily intended to avoid contamination of cell cultures and transmitting potential microbial contaminants to animals in preclinical studies of efficacy, biodistribution, and toxicity. Other methods common to microbiology will likely work equally well. JF - Methods in molecular biology (Clifton, N.J.) AU - Potter, Timothy M AU - Dobrovolskaia, Marina A AD - Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD, USA. Y1 - 2011 PY - 2011 DA - 2011 SP - 131 EP - 134 VL - 697 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Yeasts -- isolation & purification KW - Animals KW - Micropore Filters -- microbiology KW - Cell Culture Techniques KW - Fungi -- isolation & purification KW - Chemistry, Pharmaceutical -- methods KW - Drug Contamination -- prevention & control KW - Bacteria -- isolation & purification KW - Bacteria -- classification KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815552402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Analysis+of+microbial+contamination+in+nanoparticle+formulations.&rft.au=Potter%2C+Timothy+M%3BDobrovolskaia%2C+Marina+A&rft.aulast=Potter&rft.aufirst=Timothy&rft.date=2011-01-01&rft.volume=697&rft.issue=&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=1940-6029&rft_id=info:doi/10.1007%2F978-1-60327-198-1_13 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-13 N1 - Date created - 2010-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-60327-198-1_13 ER - TY - JOUR T1 - Quantitation of nanoparticles in serum matrix by capillary electrophoresis. AN - 815552205; 21116963 AB - Sensitive and fast analytical techniques are needed to determine the concentration of nanoparticles in biological samples (e.g., blood and tissues) for biodistribution and toxicity studies. This chapter describes a method for the use of capillary zone electrophoresis (CZE) and micellar electrokinetic chromatography (MEKC) for the quantitation of fullerene nanoparticles in human serum matrix. Data on the fullerene-based nanoparticle carboxyfullerene (C3 fullerene) in human serum is presented as an example. JF - Methods in molecular biology (Clifton, N.J.) AU - Chan, King C AU - Veenstra, Timothy D AU - Issaq, Haleem J AD - Laboratory of Proteomics and Analytical Technologies, Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD, USA. Y1 - 2011 PY - 2011 DA - 2011 SP - 145 EP - 153 VL - 697 KW - Fullerenes KW - 0 KW - Index Medicus KW - Fullerenes -- pharmacokinetics KW - Humans KW - Reference Standards KW - Fullerenes -- analysis KW - Calibration KW - Tissue Distribution KW - Fullerenes -- blood KW - Chromatography, Micellar Electrokinetic Capillary -- methods KW - Serum -- chemistry KW - Nanoparticles -- analysis KW - Electrophoresis, Capillary -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815552205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Quantitation+of+nanoparticles+in+serum+matrix+by+capillary+electrophoresis.&rft.au=Chan%2C+King+C%3BVeenstra%2C+Timothy+D%3BIssaq%2C+Haleem+J&rft.aulast=Chan&rft.aufirst=King&rft.date=2011-01-01&rft.volume=697&rft.issue=&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=1940-6029&rft_id=info:doi/10.1007%2F978-1-60327-198-1_15 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-13 N1 - Date created - 2010-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-60327-198-1_15 ER - TY - JOUR T1 - Structural and functional studies of the human selenium binding protein-1 and its involvement in hepatocellular carcinoma AN - 1823947341; 14602635 AB - The reduced expression of human selenium binding protein-1 (SELENBP1) has been reported for some human cancers. In this work we have estimated a reduced SELENBP1 expression by immunohistochemistry for the first time also in liver tissues of patients with hepatocarcinoma (HCC). Since the structure-function relationships of SELENBP1 are unknown, we have performed computational and experimental studies to have insight on the structural features of this protein focusing our attention on the properties of cysteines to assess their ability to interact with selenium. We have performed CD studies on the purified protein, modeled its three-dimensional structure, studied the energetic stability of the protein by molecular dynamics simulations, and titrated the cysteines by DTNB (5,5'-dithiobis (2-nitrobenzoic acid). The secondary structure content evaluated by CD has been found similar to that of 3D model. Our studies demonstrate that (i) SELENBP1 is an alpha-beta protein with some loop regions characterized by the presence of intrinsically unordered segments, (ii) only one cysteine (Cys57) is enough exposed to solvent, located on a loop and surrounded by charged and hydrophobic residues, and can be the cysteine able to bind the selenium. Furthermore, during the molecular dynamics simulation at neutral pH the loop containing Cys57 opens and exposes this residue to solvent, confirming that it is the best candidate to bind the selenium. Experimentally we found that only one cysteine is titratable by DTNB. This supports the hypothesis that Cys57 is a residue functionally important and this may open new pharmacological perspectives. JF - Biochimica et Biophysica Acta: Proteins and Proteomics AU - Raucci, Raffaele AU - Colonna, Giovanni AU - Guerriero, Eliana AU - Capone, Francesca AU - Accardo, Marina AU - Castello, Giuseppe AU - Costantini, Susan AD - INT-CROM, "Pascale Foundation" National Cancer Institute - Cancer Research Center, via Ammiraglio Bianco, 83013 Mercogliano, Italy, susan.costantini@unina2.it Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 513 EP - 522 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 1814 IS - 4 SN - 1570-9639, 1570-9639 KW - Biotechnology and Bioengineering Abstracts KW - Selenium binding protein KW - Structural model KW - Molecular dynamics KW - Hepatocarcinoma KW - Hepatocarcinoma prognosis KW - Secondary structure KW - Solvents KW - Hydrophobicity KW - Computer applications KW - Models KW - Protein structure KW - Selenium KW - Structure-function relationships KW - Cysteine KW - proteomics KW - Immunohistochemistry KW - pH effects KW - Hepatocellular carcinoma KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1823947341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+Biophysica+Acta%3A+Proteins+and+Proteomics&rft.atitle=Structural+and+functional+studies+of+the+human+selenium+binding+protein-1+and+its+involvement+in+hepatocellular+carcinoma&rft.au=Raucci%2C+Raffaele%3BColonna%2C+Giovanni%3BGuerriero%2C+Eliana%3BCapone%2C+Francesca%3BAccardo%2C+Marina%3BCastello%2C+Giuseppe%3BCostantini%2C+Susan&rft.aulast=Raucci&rft.aufirst=Raffaele&rft.date=2011-01-01&rft.volume=1814&rft.issue=4&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+Biophysica+Acta%3A+Proteins+and+Proteomics&rft.issn=15709639&rft_id=info:doi/10.1016%2Fj.bbapap.2011.02.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-09-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Secondary structure; Solvents; Molecular dynamics; Hydrophobicity; Computer applications; Models; Protein structure; Selenium; Cysteine; Structure-function relationships; proteomics; pH effects; Immunohistochemistry; Hepatocellular carcinoma DO - http://dx.doi.org/10.1016/j.bbapap.2011.02.006 ER - TY - JOUR T1 - Digit ratio (2D:4D) asymmetry and Schneiderian first rank symptoms: Implications for cerebral lateralisation theories of schizophrenia AN - 1823506437; 201120970 AB - Schneiderian first rank symptoms (FRS) in schizophrenia have been hypothesised to be secondary to aberrant cerebral lateralisation over the course of human evolution. The ratio of length of second digit to fourth digit (2D:4D) has been put forward as a potential indicator of cerebral lateralisation. This study examined 2D:4D and its asymmetry in antipsychotic-naive schizophrenia patients (N=79) in comparison with healthy controls (N=75). Psychopathology was assessed using Scales for Assessment of Positive and Negative Symptoms. FRS assessment was performed as per established descriptions. The digit lengths (2D & 4D) were measured using a digital vernier caliper with good inter-rater reliability. Female schizophrenia patients showed significantly lower 2D:4D than female healthy controls. Mean 2D:4D asymmetry index was significantly lower in male schizophrenia patients than male healthy controls. FRS status had significant effect on left 2D:4D as well as 2D:4D asymmetry index, the patients with FRS having the lowest values. Our study findings support association between Schneiderian FRS and low 2D:4D as well as low 2D:4D asymmetry index. Since 2D:4D is linked with limbic asymmetry, our study findings offer further support to the cerebral lateralisation theories of schizophrenia. Adapted from the source document. JF - Laterality: Asymmetries of Body, Brain and Cognition AU - Venkatasubramanian, Ganesan AU - Arasappa, Rashmi AU - Rao, Naren P AU - Gangadhar, Bangalore N AD - National Institute of Mental Health & Neurosciences, Bangalore, India Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 499 EP - 512 PB - Psychology Press/Taylor & Francis, Hove UK VL - 16 IS - 4 SN - 1357-650X, 1357-650X KW - Assessment KW - Schizophrenia KW - Symptoms KW - Negative symptoms KW - Men KW - Psychopathology KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1823506437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laterality%3A+Asymmetries+of+Body%2C+Brain+and+Cognition&rft.atitle=Digit+ratio+%282D%3A4D%29+asymmetry+and+Schneiderian+first+rank+symptoms%3A+Implications+for+cerebral+lateralisation+theories+of+schizophrenia&rft.au=Venkatasubramanian%2C+Ganesan%3BArasappa%2C+Rashmi%3BRao%2C+Naren+P%3BGangadhar%2C+Bangalore+N&rft.aulast=Venkatasubramanian&rft.aufirst=Ganesan&rft.date=2011-01-01&rft.volume=16&rft.issue=4&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=Laterality%3A+Asymmetries+of+Body%2C+Brain+and+Cognition&rft.issn=1357650X&rft_id=info:doi/10.1080%2F1357650X.2010.499910 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-27 N1 - CODEN - LATEFV N1 - SubjectsTermNotLitGenreText - Schizophrenia; Assessment; Men; Symptoms; Psychopathology; Negative symptoms DO - http://dx.doi.org/10.1080/1357650X.2010.499910 ER - TY - JOUR T1 - Gene Therapy of Canine Leukocyte Adhesion Deficiency Using Lentiviral Vectors With Human CD11b and CD18 Promoters Driving Canine CD18 Expression AN - 1808648989; PQ0003367573 AB - To identify cellular promoters in a self-inactivating (SIN) lentiviral vector that might be beneficial in treating children with leukocyte adhesion deficiency type 1 (LAD-1), we tested lentiviral vectors with human CD11 and CD18 leukocyte integrin proximal promoter elements directing expression of canine CD18 in animals with canine LAD (CLAD). Lentiviral vectors with either the human CD11b (637 bp) proximal promoter or the human CD18 (1,060 bp) proximal promoter resulted in the highest percentages of CD18 super(+) CLAD CD34 super(+) cells in vitro. Subsequently, two CLAD dogs were infused with autologous CD34 super(+) cells transduced with the hCD11b (637 bp)-cCD18 vector, and two CLAD dogs were infused with autologous CD34 super(+) cells transduced with the hCD18 (1,060 bp)-cCD18 vector. Each dog received a nonmyeloablative dose of 200 cGy total body irradiation (TBI) before the infusion of transduced cells. The two CLAD dogs treated with the hCD18 (1,060 bp)-cCD18 vector, and one of the two dogs treated with the hCD11b (637 bp)-cCD18 vector, had reversal of the CLAD phenotype. These studies using endogenous leukocyte integrin proximal promoters represent an important step in the development of gene therapy for children with LAD-1. JF - Molecular Therapy AU - Hunter, Michael J AU - Tuschong, Laura M AU - Fowler, Cedar J AU - Bauer, Thomas R, Jr AU - Burkholder, Tanya H AU - Hickstein, Dennis D AD - Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA, huntermj@mail.nih.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 113 EP - 121 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 19 IS - 1 SN - 1525-0016, 1525-0016 KW - Immunology Abstracts; Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Expression vectors KW - Promoters KW - Gene therapy KW - Radiation KW - Integrins KW - CD11b antigen KW - Leukocytes KW - CD34 antigen KW - Children KW - CD18 antigen KW - W 30905:Medical Applications KW - V 22410:Animal Diseases KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808648989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=Gene+Therapy+of+Canine+Leukocyte+Adhesion+Deficiency+Using+Lentiviral+Vectors+With+Human+CD11b+and+CD18+Promoters+Driving+Canine+CD18+Expression&rft.au=Hunter%2C+Michael+J%3BTuschong%2C+Laura+M%3BFowler%2C+Cedar+J%3BBauer%2C+Thomas+R%2C+Jr%3BBurkholder%2C+Tanya+H%3BHickstein%2C+Dennis+D&rft.aulast=Hunter&rft.aufirst=Michael&rft.date=2011-01-01&rft.volume=19&rft.issue=1&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Molecular+Therapy&rft.issn=15250016&rft_id=info:doi/10.1038%2Fmt.2010.203 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Expression vectors; Promoters; Radiation; Gene therapy; Integrins; CD11b antigen; Leukocytes; CD34 antigen; Children; CD18 antigen DO - http://dx.doi.org/10.1038/mt.2010.203 ER - TY - JOUR T1 - Chicken HS4 Insulators Have Minimal Barrier Function Among Progeny of Human Hematopoietic Cells Transduced With an HIV1-based Lentiviral Vector AN - 1808625802; PQ0003367575 AB - Position effects limit the curative potential of gene transfer strategies for the hemoglobinopathies by inducing clonal variability of transgene expression. We evaluated the mitigating effects of the chicken hypersensitivity site 4 (HS4) insulator among lentiviral vector-transduced human hematopoietic cells. We constructed various lentiviral vectors using a green fluorescent protein (GFP) reporter under the control of a reverse-oriented murine stem cell virus (MSCV)-long-term repeat (LTR) promoter or a reverse-oriented [beta]-globin expression cassette. A full-length HS4, a tandem HS4 core, and a single core insulator were inserted into the 3' LTR in both forward and reverse orientation. All but the reverse single core insulator significantly decreased titers. All reduced %GFP without increasing mean fluorescence intensity (MFI) among erythroid progeny of transduced human CD34 super(+) cells. A lower coefficient of variation (CV) was observed only among progeny of the full-length vector-transduced cells, yet a fivefold reduction in transduction efficiency was observed. In xenografted mice, the single core insulator decreased both the %GFP and the MFI at 4 and 8 weeks after transplantation with no difference in CVs. These data demonstrate that the inclusion of HS4 insulator elements lowers viral titers, reduces efficiency of transduction, and produces minimal effects on transgene expression among human hematopoietic cells in vitro and in vivo. JF - Molecular Therapy AU - Uchida, Naoya AU - Washington, Kareem N AU - Lap, Coen J AU - Hsieh, Matthew M AU - Tisdale, John F AD - Molecular and Clinical Hematology Branch, National Heart Lung and Blood Institutes (NHLBI)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland, USA, johntis@mail.nih.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 133 EP - 139 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 19 IS - 1 SN - 1525-0016, 1525-0016 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Fluorescence KW - Data processing KW - Transgenes KW - Green fluorescent protein KW - CD34 antigen KW - Expression vectors KW - Promoters KW - Hypersensitivity KW - Position effects KW - Stem cells KW - Human immunodeficiency virus KW - Gene transfer KW - Hemopoiesis KW - Progeny KW - Hemoglobinopathy KW - W 30905:Medical Applications KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808625802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=Chicken+HS4+Insulators+Have+Minimal+Barrier+Function+Among+Progeny+of+Human+Hematopoietic+Cells+Transduced+With+an+HIV1-based+Lentiviral+Vector&rft.au=Uchida%2C+Naoya%3BWashington%2C+Kareem+N%3BLap%2C+Coen+J%3BHsieh%2C+Matthew+M%3BTisdale%2C+John+F&rft.aulast=Uchida&rft.aufirst=Naoya&rft.date=2011-01-01&rft.volume=11&rft.issue=&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=BMC+Microbiology&rft.issn=1471-2180&rft_id=info:doi/10.1186%2F1471-2180-11-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Data processing; Fluorescence; Transgenes; Green fluorescent protein; CD34 antigen; Expression vectors; Promoters; Stem cells; Position effects; Hypersensitivity; Gene transfer; Hemopoiesis; Progeny; Hemoglobinopathy; Human immunodeficiency virus DO - http://dx.doi.org/10.1038/mt.2010.218 ER - TY - JOUR T1 - Rare earth elements in the ornithogenic sediments from the maritime Antarctic; a potential new palaeoecology proxy AN - 1784738302; 2016-036612 AB - The ornithogenic sediments in the maritime Antarctic are good archives for studying the changes of historical penguin population. Rare earth elements (REEs) along with biological and lithophile elements in two lacustrine sediment cores (Y2 and Y4) influenced by penguin droppings were analyzed with the aim of evaluating their potential as a new palaeoecological proxy. The relative concentrations of REEs in the two cores show dramatic changes, and the average REE contents are 71.21+ or -11.56 (n=37) and 37.18+ or -10.64 (n=18) for Y2 and Y4, respectively. The REE light/heavy content ratios (L/H) are 4.48+ or -0.59 for Y2 and 4.70+ or -0.62 for Y4, very close to the mean ratio of four pure guano samples. The chondrite normalized REE patterns in the Y2 and Y4 sediments significantly influenced by penguin droppings are characteristic of more fractionation, obviously negative Ce anomalies and positive Er anomalies, likely imprinting the REE signal of guano input. The total REE concentration has a statistically significant negative correlation with the levels of guano-derived bio-elements and a positive correlation with the levels of Sc and Al mainly originated from weathered soils The calculated proportion of guano-derived REE based on two-member mixing equation has a change pattern consistent with that of the historical penguin population size, previously reconstructed from bio-element concentrations in the sediments. These results suggest that the non-crustal signature of REE in the ornithogenic sediments may provide a new palacoecological proxy for studying the palaeoecological processes of Antarctic penguins on a large time scale. JF - Geochemical Journal AU - Liu, Xiaodong AU - Sun, Liguang AU - Li, Dan AU - Wang, Yuhong Y1 - 2011 PY - 2011 DA - 2011 SP - 15 EP - 26 PB - Geochemical Society of Japan, Nagoya VL - 45 IS - 1 SN - 0016-7002, 0016-7002 KW - Holocene KW - Ardley Island KW - lithophile elements KW - cores KW - paleoecology KW - guano KW - cerium KW - Cenozoic KW - aluminum KW - tracers KW - sediments KW - ecology KW - rare earths KW - soils KW - Neornithes KW - erbium KW - Chordata KW - Quaternary KW - Neognathae KW - Aves KW - populations KW - Antarctica KW - Sphenisciformes KW - metals KW - lacustrine environment KW - scandium KW - Vertebrata KW - Tetrapoda KW - lake sediments KW - 24:Quaternary geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1784738302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochemical+Journal&rft.atitle=Rare+earth+elements+in+the+ornithogenic+sediments+from+the+maritime+Antarctic%3B+a+potential+new+palaeoecology+proxy&rft.au=Liu%2C+Xiaodong%3BSun%2C+Liguang%3BLi%2C+Dan%3BWang%2C+Yuhong&rft.aulast=Liu&rft.aufirst=Xiaodong&rft.date=2011-01-01&rft.volume=45&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Geochemical+Journal&rft.issn=00167002&rft_id=info:doi/10.2343%2Fgeochemj.1.0087 L2 - http://www.terrapub.co.jp/journals/GJ/index.html LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2016-01-01 N1 - Number of references - 48 N1 - Document feature - illus. incl. 3 tables, sketch map N1 - Last updated - 2016-04-28 N1 - CODEN - GEJOBE N1 - SubjectsTermNotLitGenreText - aluminum; Antarctica; Ardley Island; Aves; Cenozoic; cerium; Chordata; cores; ecology; erbium; guano; Holocene; lacustrine environment; lake sediments; lithophile elements; metals; Neognathae; Neornithes; paleoecology; populations; Quaternary; rare earths; scandium; sediments; soils; Sphenisciformes; Tetrapoda; tracers; Vertebrata DO - http://dx.doi.org/10.2343/geochemj.1.0087 ER - TY - JOUR T1 - Serum Antioxidant Status Is Associated with Metabolic Syndrome among U.S. Adults in Recent National Surveys AN - 1758238396; 14700060 AB - Potential antiinflammatory and antioxidant effects were recently ascribed to naturally occurring micronutrients. The extent and magnitudes of their differential effects on the metabolic syndrome (MetS) are still unknown. We examined the association between serum antioxidant status and MetS. NHANES 2001-2006 cross-sectional data among adults aged 20-85 y were analyzed (n = 3008-9099). MetS was defined with the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and also by elevated homeostatic model assessment insulin resistance (HOMA-IR), C-reactive protein (CRP) and hyperuricemia. Serum antioxidants included retinol, retinyl esters, carotenoids [ alpha -carotene, beta -carotene (cis+trans), beta -cryptoxanthin, lutein+zeaxanthin, total lycopene], vitamin E, and vitamin C. MetS (NCEP ATP III) prevalence in U.S. adults was 32.0% among men and 29.5% among women. Adults with MetS had consistently lower serum carotenoid concentrations compared with those without MetS, even after controlling for total cholesterol and TG among other potential confounders. Vitamin E had no significant relationship with MetS in the full multiple logistic regression model, whereas retinol+retinyl esters were inversely related to MetS among men only. The latter were also inversely related to elevated CRP and positively associated with hyperuricemia. Vitamin C exhibited a similar pattern to serum carotenoids with an inverse linear association with MetS (binary), HOMA-IR, and hyperuricemia. Future intervention studies of dietary and lifestyle change must be conducted to assess the utility of modifying serum antioxidant concentrations, especially carotenoids, given their suboptimal levels among U.S. adults with MetS, for the prevention of type 2 diabetes and various cardiovascular endpoints. JF - Journal of Nutrition AU - Beydoun, May A AU - Shroff, Monal R AU - Chen, Xiaoli AU - Beydoun, Hind A AU - Wang, Youfa AU - Zonderman, Alan B AD - National Institute on Aging, National Institute of Health, Intramural Research Program, Baltimore, MD 21224 PY - 2011 SP - 903 EP - 913 PB - American Society for Nutritional Sciences, 9650 Rockville Pike, Room L-2407A Bethesda MD 20814 USA VL - 141 IS - 5 SN - 0022-3166, 0022-3166 KW - Toxicology Abstracts KW - Antioxidants KW - Data processing KW - Metabolic disorders KW - ATP KW - Hyperuricemia KW - Cholesterol KW - Esters KW - Insulin KW - Models KW - Ascorbic acid KW - Diabetes mellitus KW - Vitamin E KW - Vitamin A KW - Regression analysis KW - beta -Carotene KW - lycopene KW - Micronutrients KW - Carotenoids KW - C-reactive protein KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1758238396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nutrition&rft.atitle=Serum+Antioxidant+Status+Is+Associated+with+Metabolic+Syndrome+among+U.S.+Adults+in+Recent+National+Surveys&rft.au=Beydoun%2C+May+A%3BShroff%2C+Monal+R%3BChen%2C+Xiaoli%3BBeydoun%2C+Hind+A%3BWang%2C+Youfa%3BZonderman%2C+Alan+B&rft.aulast=Beydoun&rft.aufirst=May&rft.date=2011-01-01&rft.volume=141&rft.issue=5&rft.spage=903&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Data processing; Antioxidants; Metabolic disorders; Hyperuricemia; ATP; Cholesterol; Esters; Insulin; Ascorbic acid; Models; Diabetes mellitus; Vitamin E; Vitamin A; beta -Carotene; Regression analysis; lycopene; Micronutrients; Carotenoids; C-reactive protein ER - TY - JOUR T1 - Urinary pH, cigarette smoking and bladder cancer risk AN - 1660409789; 18514226 AB - Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolite can be rapidly hydrolyzed in acidic urine to undergo further metabolic activation and form DNA adducts in the urothelium. We conducted a large multicenter case-control study in Spain to explore the etiology of bladder cancer and evaluated the association between urine pH and bladder cancer risk, alone and in combination with cigarette smoking. In total, 712 incident urothelial cell carcinoma cases and 611 hospital controls directly measured their urine pH with dipsticks twice a day (first void in the morning and early in the evening) during four consecutive days 2 weeks after hospital discharge. We found that a consistently acidic urine pH less than or equal to 6.0 was associated with an increased risk of bladder cancer [odds ratio (OR) = 1.5, 95% confidence interval (CI): 1.2-1.9] compared with all other subjects. Furthermore, risk estimates for smoking intensity and risk of bladder cancer among current smokers tended to be higher for those with a consistently acidic urine (OR = 8.8, 11.5 and 23.8) compared with those without (OR = 4.3, 7.7 and 5.8, respectively, for 1-19, 20-29 and 30+ cigarettes per day; P sub(interaction) for 30+ cigarettes per day = 0.024). These results suggest that urine pH, which is determined primarily by diet and body surface area, may be an important modifier of smoking and risk of bladder cancer. JF - Carcinogenesis AU - Alguacil, Juan AU - Kogevinas, Manolis AU - Silverman, Debra T AU - Malats, Nuria AU - Real, Francisco X AU - Garcia-Closas, Montserrat AU - Tardon, Adonina AU - Rivas, Manuel AU - Tora, Montserrat AU - Garcia-Closas, Reina AU - Serra, Consol AU - Carrato, Alfredo AU - Pfeiffer, Ruth M AU - Fortuny, Joan AU - Samanic, Claudine AU - Rothman, Nathaniel AD - 1 Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA, alguacil@dbasp.uhu.es Y1 - 2011 PY - 2011 DA - 2011 SP - 843 EP - 847 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 32 IS - 6 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - Diets KW - DNA adducts KW - Etiology KW - Urinary bladder KW - Surface area KW - urothelium KW - urothelial carcinoma KW - Urine KW - Carcinogenesis KW - Cigarette smoking KW - Metabolic activation KW - pH effects KW - Hospitals KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660409789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Urinary+pH%2C+cigarette+smoking+and+bladder+cancer+risk&rft.au=Alguacil%2C+Juan%3BKogevinas%2C+Manolis%3BSilverman%2C+Debra+T%3BMalats%2C+Nuria%3BReal%2C+Francisco+X%3BGarcia-Closas%2C+Montserrat%3BTardon%2C+Adonina%3BRivas%2C+Manuel%3BTora%2C+Montserrat%3BGarcia-Closas%2C+Reina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BPfeiffer%2C+Ruth+M%3BFortuny%2C+Joan%3BSamanic%2C+Claudine%3BRothman%2C+Nathaniel&rft.aulast=Alguacil&rft.aufirst=Juan&rft.date=2011-01-01&rft.volume=32&rft.issue=6&rft.spage=843&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgr048 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-03-04 N1 - SubjectsTermNotLitGenreText - Diets; DNA adducts; Etiology; Urinary bladder; Surface area; urothelium; urothelial carcinoma; Urine; Cigarette smoking; Carcinogenesis; Metabolic activation; pH effects; Hospitals DO - http://dx.doi.org/10.1093/carcin/bgr048 ER - TY - JOUR T1 - Executive summary-Nutritional Care of HIV-Infected Adolescents and Adults, including Pregnant and Lactating Women: What Do We Know, What Can We Do, and Where Do We Go from Here? AN - 1520372024; 16079774 AB - The HIV pandemic continues to place an unbearable burden on the international community, with disease prevalence remaining highest in resource-limited settings in Africa, Asia, and the Americas. HIV is most often imposed on conditions of food insecurity and consequent malnutrition, poor sanitation, and chronic exposure to a myriad of infectious (eg, malaria, tuberculosis, and diarrheal) and noncommunicable (eg, obesity, diabetes, cancer, and cardiovascular) diseases. Women and children continue to bear the greatest burden. Two essential tenets underpin our approach to HIV: 1) antiretroviral drugs (ARVs) are essential to prolong lives and to halt the spread of HIV and AIDS and 2) food and sound nutrition are essential to human health. The challenge is to apply sound principles of clinical care and nutrition science to the safe and efficacious implementation of ARVs and for long-term care for people living with HIV and AIDS. The WHO has played a leading role in developing guidelines to support this goal with the generation of general recommendations regarding nutritional needs of people living with HIV and AIDS and specific guidelines for the nutritional care of HIV-infected infants and children (<14 y of age). These proceedings represent a summary of the work accomplished at a workshop sponsored by the NIH to review the existing evidence to support changes in the recommendations regarding nutrient requirements for people living with HIV and AIDS; to support development of new WHO guidelines for adolescents and adults, including for pregnant and lactating women; and to identify a research agenda to address outstanding knowledge gaps. JF - American Journal of Clinical Nutrition AU - Raiten, Daniel J AU - Mulligan, Kathleen AU - Papathakis, Peggy AU - Wanke, Christine AD - From the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (DJR) Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 1667S EP - 1676S PB - American Society for Clinical Nutrition, 3247 Meyer Hall, University of California Davis CA 95616-8790 United States VL - 94 IS - 6 SN - 0002-9165, 0002-9165 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Human diseases KW - Mycobacterium KW - Women KW - Malaria KW - Nutrition KW - Public health KW - Disease transmission KW - Human immunodeficiency virus KW - Human immunodeficiency virus 1 KW - Africa KW - Tuberculosis KW - Asia KW - Drugs KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520372024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Clinical+Nutrition&rft.atitle=Executive+summary-Nutritional+Care+of+HIV-Infected+Adolescents+and+Adults%2C+including+Pregnant+and+Lactating+Women%3A+What+Do+We+Know%2C+What+Can+We+Do%2C+and+Where+Do+We+Go+from+Here%3F&rft.au=Raiten%2C+Daniel+J%3BMulligan%2C+Kathleen%3BPapathakis%2C+Peggy%3BWanke%2C+Christine&rft.aulast=Raiten&rft.aufirst=Daniel&rft.date=2011-01-01&rft.volume=94&rft.issue=6&rft.spage=1667S&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Clinical+Nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Human diseases; Women; Malaria; Tuberculosis; Drugs; Nutrition; Disease transmission; Public health; Mycobacterium; Human immunodeficiency virus; Human immunodeficiency virus 1; Africa; Asia ER - TY - JOUR T1 - DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas AN - 1439222289; 18514207 AB - DNA damage is thought to play a critical role in the development of colorectal adenoma. Variation in DNA repair genes may alter their capacity to correct endogenous and exogenous DNA damage. We explored the association between common single-nucleotide polymorphisms (SNPs) in DNA repair genes and adenoma risk with a case-control study nested in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. A total of 1338 left sided, advanced colorectal adenoma cases and 1503 matched controls free of left-sided polyps were included in the study. Using DNA extracted from blood, 3144 tag SNPs in 149 DNA repair genes were successfully genotyped. Among Caucasians, 30 SNPs were associated with adenoma risk at P < 0.01, with four SNPs remaining significant after gene-based adjustment for multiple testing. The most significant finding was for a non-synonymous SNP (rs9350) in Exonuclease-1 (EXO1) [odds ratio (OR) = 1.30, 95% confidence interval (CI) = 1.11-1.51, P = 0.001)], which was predicted to be damaging using bioinformatics methods. However, the association was limited to smokers with a strong risk for current smokers (OR = 2.15, 95% CI = 1.27-3.65) and an intermediate risk for former smokers (OR = 1.45, 95% CI = 1.14-1.82) and no association for never smokers (OR = 0.98, 95% CI = 0.76-1.25) (P sub(interaction) = 0.002). Among the top findings, an SNP (rs17503908) in ataxia telangiectasia mutated (ATM) was inversely related to adenoma risk (OR = 0.75, 95% CI = 0.63-0.91). The association was restricted to never smokers (OR = 0.55, 95% CI = 0.40-0.76) with no increased risk observed among smokers (OR = 0.89, 95% CI = 0.70-1.13) (P sub(interaction) = 0.006). This large comprehensive study, which evaluated all presently known DNA repair genes, suggests that polymorphisms in EXO1 and ATM may be associated with risk for advanced colorectal adenoma with the associations modified by tobacco-smoking status. JF - Carcinogenesis AU - Gao, Ying AU - Hayes, Richard B AU - Huang, Wen-Yi AU - Caporaso, Neil E AU - Burdette, Laurie AU - Yeager, Meredith AU - Chanock, Stephen J AU - Berndt, Sonja I AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7236, USA, gaoying@mail.nih.gov Y1 - 2011 PY - 2011 DA - 2011 SP - 882 EP - 887 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 32 IS - 6 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts; Oncogenes & Growth Factors Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - Adenoma KW - N:14820 KW - X:24380 KW - G:07730 KW - B:26640 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1439222289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=DNA+repair+gene+polymorphisms+and+tobacco+smoking+in+the+risk+for+colorectal+adenomas&rft.au=Gao%2C+Ying%3BHayes%2C+Richard+B%3BHuang%2C+Wen-Yi%3BCaporaso%2C+Neil+E%3BBurdette%2C+Laurie%3BYeager%2C+Meredith%3BChanock%2C+Stephen+J%3BBerndt%2C+Sonja+I&rft.aulast=Gao&rft.aufirst=Ying&rft.date=2011-01-01&rft.volume=4&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Molecular+Brain&rft.issn=1756-6606&rft_id=info:doi/10.1186%2F1756-6606-4-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Adenoma DO - http://dx.doi.org/10.1093/carcin/bgr071 ER - TY - JOUR T1 - Mapping mouse IL-13 binding regions using structure modeling, molecular docking, and high-density peptide microarray analysis AN - 1434023974; 18540185 AB - Interleukin-13 is a Th2-associated cytokine responsible for many pathological responses in allergic asthma including mucus production, inflammation, and extracellular matrix remodeling. In addition, IL-13 is required for immunity to many helminth infections. IL-13 signals via the type-II IL-4 receptor, a heterodimeric receptor of IL-13R[alpha]1 and IL-4R[alpha], which is also used by IL-4. IL-13 also binds to IL-13R[alpha]2, but with much higher affinity than the type-II IL-4 receptor. Binding of IL-13 to IL-13R[alpha]2 has been shown to attenuate IL-13 signaling through the type-II IL-4 receptor. However, molecular determinants that dictate the specificity and affinity of mouse IL-13 for the different receptors are largely unknown. Here, we used high-density overlapping peptide arrays, structural modeling, and molecular docking methods to map IL-13 binding sequences on its receptors. Predicted binding sequences on mouse IL-13R[alpha]1 and IL-13R[alpha]2 were in agreement with the reported human IL-13 receptor complex structures and site-directed mutational analysis. Novel structural differences were identified between IL-13 receptors, particularly at the IL-13 binding interface. Notably, additional binding sites were observed for IL-13 on IL-13R[alpha]2. In addition, the identification of peptide sequences that are unique to IL-13R[alpha]1 allowed us to generate a monoclonal antibody that selectively binds IL-13R[alpha]1. Thus, high-density peptide arrays combined with molecular docking studies provide a novel, rapid, and reliable method to map cytokine-receptor interactions that may be used to generate signaling and decoy receptor-specific antagonists. Proteins 2010. [copy 2010 Wiley-Liss, Inc. JF - Proteins: Structure, Function and Bioinformatics AU - Madala, Satish K AU - Dolan, Michael A AU - Sharma, Deepak AU - Ramalingam, Thirumalai R AU - Wilson, Mark S AU - Mentink-Kane, Margaret M AU - Masison, Daniel C AU - Wynn, Thomas A AD - Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892., twynn@niaid.nih.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 282 EP - 293 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030 United States VL - 79 IS - 1 SN - 0887-3585, 0887-3585 KW - Biotechnology and Bioengineering Abstracts KW - Interleukin 4 KW - Peptide mapping KW - Monoclonal antibodies KW - Asthma KW - Mucus KW - Immunity KW - Infection KW - Antagonists KW - Inflammation KW - Protein structure KW - Hypersensitivity KW - Interleukin 13 KW - Extracellular matrix KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1434023974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteins%3A+Structure%2C+Function+and+Bioinformatics&rft.atitle=Mapping+mouse+IL-13+binding+regions+using+structure+modeling%2C+molecular+docking%2C+and+high-density+peptide+microarray+analysis&rft.au=Madala%2C+Satish+K%3BDolan%2C+Michael+A%3BSharma%2C+Deepak%3BRamalingam%2C+Thirumalai+R%3BWilson%2C+Mark+S%3BMentink-Kane%2C+Margaret+M%3BMasison%2C+Daniel+C%3BWynn%2C+Thomas+A&rft.aulast=Madala&rft.aufirst=Satish&rft.date=2011-01-01&rft.volume=79&rft.issue=1&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=Proteins%3A+Structure%2C+Function+and+Bioinformatics&rft.issn=08873585&rft_id=info:doi/10.1002%2Fprot.22881 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-09-01 N1 - Last updated - 2013-09-20 N1 - SubjectsTermNotLitGenreText - Interleukin 4; Peptide mapping; Monoclonal antibodies; Asthma; Mucus; Immunity; Infection; Antagonists; Inflammation; Protein structure; Interleukin 13; Hypersensitivity; Extracellular matrix; Bioinformatics DO - http://dx.doi.org/10.1002/prot.22881 ER - TY - JOUR T1 - Two-Year Toxicity and Carcinogenicity Studies of Panax ginseng in Fischer 344 Rats and B6C3F1 Mice AN - 1356925883; 15497912 AB - Ginseng is one of the most popular herbal supplements on the US market. Numerous reports of adverse effects from products containing ginseng have been filed with the US Food and Drug Administration (FDA) and the literature documents a "ginseng abuse syndrome" among regular users. However, the chronic toxic effects of ginseng are not well characterized. Because of its significant human exposure and the fact that little information on its toxicity is available, Panax ginseng was nominated by the US National Institutes of Health (NIH) to the US National Toxicology Program (NTP) to assess its carcinogenic potential. In this paper, we reported the results of NTP chronic toxicity and tumorigenicity bioassay. It shows that, under these experimental conditions, Panax ginseng is not toxic or tumorigenic. JF - American Journal of Chinese Medicine AU - Chan, P-C AU - Peckham, J C AU - Malarkey, DE AU - Kissling, GE AU - Travlos, G S AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA, chanp@niehs.nih.gov Y1 - 2011 PY - 2011 DA - 2011 SP - 779 EP - 788 VL - 39 IS - 4 SN - 0192-415X, 0192-415X KW - Toxicology Abstracts KW - Panax ginseng KW - Carcinogenicity KW - Dietary supplements KW - Chronic toxicity KW - Tumorigenicity KW - Ginseng KW - Toxicity KW - Side effects KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1356925883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Chinese+Medicine&rft.atitle=Two-Year+Toxicity+and+Carcinogenicity+Studies+of+Panax+ginseng+in+Fischer+344+Rats+and+B6C3F1+Mice&rft.au=Chan%2C+P-C%3BPeckham%2C+J+C%3BMalarkey%2C+DE%3BKissling%2C+GE%3BTravlos%2C+G+S&rft.aulast=Chan&rft.aufirst=P-C&rft.date=2011-01-01&rft.volume=39&rft.issue=4&rft.spage=779&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Chinese+Medicine&rft.issn=0192415X&rft_id=info:doi/10.1142%2FS0192415X11009184 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Last updated - 2013-06-14 N1 - SubjectsTermNotLitGenreText - Carcinogenicity; Chronic toxicity; Dietary supplements; Tumorigenicity; Ginseng; Toxicity; Side effects; Panax ginseng DO - http://dx.doi.org/10.1142/S0192415X11009184 ER - TY - JOUR T1 - Interdisciplinary research on patient-provider communication: A cross-method comparison AN - 1221439791; 201216974 AB - Patient-provider communication, a key aspect of healthcare delivery, has been assessed through multiple methods for purposes of research, education, and quality control. Common techniques include satisfaction ratings and quantitatively- and qualitatively- oriented direct observations. Identifying the strengths and weaknesses of different approaches is critically important in determining the appropriate assessment method for a specific research or practical goal. Analyzing ten videotaped simulated encounters between medical students and Standardized Patients (SPs), this study compared three existing assessment methods through the same data set. Methods included: (I) dichotomized SP ratings on students' communication skills; (2) Roter Interaction Analysis System (RIAS) analysis; and (3) inductive discourse analysis informed by sociolinguistic theories. The large dichotomous contrast between good and poor ratings in (1) was not evidenced in any of the other methods. Following a discussion of strengths and weaknesses of each approach, we pilot-tested a combined assessment done by coders blinded to results of (1)-(3). This type of integrative approach has the potential of adding a quantifiable dimension to qualitative, discourse-based observations. Subjecting the same data set to separate analytic methods provides an excellent opportunity for methodological comparisons with the goal of informing future assessment of clinical encounters. Adapted from the source document JF - Communication & Medicine AU - Chou, Wen-Ying Sylvia AU - Haw, Paul AU - Pilsner, Alison AU - Coa, Kisha AU - Greenberg, Larrie AU - Blatt, Benjamin AD - 6130 Executive Blvd. EPN 4046, Bethesda, MD 20892, US chouws@mail.nih.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 29 EP - 40 VL - 8 IS - 1 SN - 1612-1783, 1612-1783 KW - Discourse Analysis (19200) KW - Patients (62950) KW - Interpersonal Communication (37700) KW - Sociolinguistics (80200) KW - Health Care Practitioners (31130) KW - Research Design (72950) KW - Practitioner Patient Relationship (66830) KW - article KW - 5510: interpersonal behavior and communication; interpersonal and group communication, behavior, and relationships UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1221439791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Communication+%26+Medicine&rft.atitle=Interdisciplinary+research+on+patient-provider+communication%3A+A+cross-method+comparison&rft.au=Chou%2C+Wen-Ying+Sylvia%3BHaw%2C+Paul%3BPilsner%2C+Alison%3BCoa%2C+Kisha%3BGreenberg%2C+Larrie%3BBlatt%2C+Benjamin&rft.aulast=Chou&rft.aufirst=Wen-Ying&rft.date=2011-01-01&rft.volume=8&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Communication+%26+Medicine&rft.issn=16121783&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2012-12-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Research Design (72950); Patients (62950); Health Care Practitioners (31130); Practitioner Patient Relationship (66830); Interpersonal Communication (37700); Discourse Analysis (19200); Sociolinguistics (80200) ER - TY - JOUR T1 - Service Utilization for Lifetime Mental Disorders in U.S Adolescents: Results of the National Comorbidity Survey-Adolescent Supplement (NCS-A) AN - 1221434948; 201229057 AB - Objective: Mental health policy for youth has been constrained by a paucity of nationally representative data concerning patterns and correlates of mental health service utilization in this segment of the population. The objectives of this investigation were to examine the rates and sociodemographic correlates of lifetime mental health service use by severity, type, and number of DSM-IV disorders in the National Comorbidity Survey-Adolescent Supplement. Method: Face-to-face survey of mental disorders from 2002 to 2004 using a modified version of the fully structured World Health Organization Composite International Diagnostic Interview in a nationally representative sample of 6,483 adolescents 13 to 18 years old for whom information on service use was available from an adolescent and a parent report. Total and sector-specific mental health service use was also assessed. Results: Approximately one third of adolescents with mental disorders received services for their illness (36.2%). Although disorder severity was significantly associated with an increased likelihood of receiving treatment, half of adolescents with severely impairing mental disorders had never received mental health treatment for their symptoms. Service rates were highest in those with attention-deficit/hyperactivity disorder (59.8%) and behavior disorders (45.4%), but fewer than one in five affected adolescents received services for anxiety, eating, or substance use disorders. Comorbidity and severe impairment were strongly associated with service utilization, particularly in youth with behavior disorders. Hispanic and non-Hispanic Black adolescents were less likely than their White counterparts to receive services for mood and anxiety disorders, even when such disorders were associated with severe impairment. Conclusions: Despite advances in public awareness of mental disorders in youth, a substantial proportion of young people with severe mental disorders have never received specialty mental health care. Marked racial disparities in lifetime rates of mental health treatment highlight the urgent need to identify and combat barriers to the recognition and treatment of these conditions. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Merikangas, Kathleen Ries AU - He, Jian-ping AU - Burstein, Marcy AU - Swendsen, Joel AU - Avenevoli, Shelli AU - Case, Brady AU - Georgiades, Katholiki AU - Heaton, Leanne AU - Swanson, Sonja AU - Olfson, Mark AD - National Institute of Mental Health, Genetic Epidemiology Research Branch, Building 35, Room 1A201, 35 Convent Drive, MSC #3720, Bethesda, MD 20892 kathleen.merikangas@nih.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 32 EP - 45 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 50 IS - 1 SN - 0890-8567, 0890-8567 KW - epidemiology, adolescents, mental disorders, treatment, services KW - Severity KW - Mental health services KW - Psychiatric disorders KW - Behaviour disorders KW - Comorbidity KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1221434948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Service+Utilization+for+Lifetime+Mental+Disorders+in+U.S+Adolescents%3A+Results+of+the+National+Comorbidity+Survey-Adolescent+Supplement+%28NCS-A%29&rft.au=Merikangas%2C+Kathleen+Ries%3BHe%2C+Jian-ping%3BBurstein%2C+Marcy%3BSwendsen%2C+Joel%3BAvenevoli%2C+Shelli%3BCase%2C+Brady%3BGeorgiades%2C+Katholiki%3BHeaton%2C+Leanne%3BSwanson%2C+Sonja%3BOlfson%2C+Mark&rft.aulast=Merikangas&rft.aufirst=Kathleen&rft.date=2011-01-01&rft.volume=50&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1016%2Fj.jaac.2010.10.006 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-12-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Adolescents; Mental health services; Psychiatric disorders; Comorbidity; Severity; Behaviour disorders DO - http://dx.doi.org/10.1016/j.jaac.2010.10.006 ER - TY - JOUR T1 - Microarray-based cancer prediction using single genes AN - 1125229668; 17278946 AB - Background: Although numerous methods of using microarray data analysis for cancer classification have been proposed, most utilize many genes to achieve accurate classification. This can hamper interpretability of the models and ease of translation to other assay platforms. We explored the use of single genes to construct classification models. We first identified the genes with the most powerful univariate class discrimination ability and then constructed simple classification rules for class prediction using the single genes. Results: We applied our model development algorithm to eleven cancer gene expression datasets and compared classification accuracy to that for standard methods including Diagonal Linear Discriminant Analysis, k-Nearest Neighbor, Support Vector Machine and Random Forest. The single gene classifiers provided classification accuracy comparable to or better than those obtained by existing methods in most cases. We analyzed the factors that determined when simple single gene classification is effective and when more complex modeling is warranted. Conclusions: For most of the datasets examined, the single-gene classification methods appear to work as well as more standard methods, suggesting that simple models could perform well in microarray-based cancer prediction. JF - BMC Bioinformatics AU - Wang, Xiaosheng AU - Simon, Richard AD - Biometric Research Branch, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 391 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 12 IS - 1 SN - 1471-2105, 1471-2105 KW - Biotechnology and Bioengineering Abstracts KW - Indexing in process UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1125229668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Microarray-based+cancer+prediction+using+single+genes&rft.au=Wang%2C+Xiaosheng%3BSimon%2C+Richard&rft.aulast=Wang&rft.aufirst=Xiaosheng&rft.date=2011-01-01&rft.volume=12&rft.issue=1&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=14712105&rft_id=info:doi/10.1186%2F1471-2105-12-391 L2 - http://www.biomedcentral.com/1471-2105/12/391 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Number of references - 51 N1 - Last updated - 2012-11-02 DO - http://dx.doi.org/10.1186/1471-2105-12-391 ER - TY - JOUR T1 - Reproducibility of Reported In Utero Exposure to Tobacco Smoke AN - 1093430958; 14255354 AB - Purpose: In studies of the fetal origins of disease and life course epidemiology, measures of fetal exposure may be based on information reported by the adults who were exposed in utero. In particular, the full spectrum of consequences of in utero exposure to maternal tobacco smoking is now an area of active investigation, and the ability to report such exposure reproducibly is of interest. We evaluated the reproducibility of in utero exposure to tobacco smoke, reported by the adult daughter during consecutive pregnancies. Methods: This study was based on 11,257 women who enrolled for more than one pregnancy in the Norwegian Mother and Child Cohort Study (MoBa). Participants completed a questionnaire around 17 weeks of gestation, which asked about their in utero exposure to tobacco smoke. Kappa statistics were calculated. Determinants of agreement were evaluated using logistic regression. Results: Weighted Kappa for in utero exposure for the first and second reports was 0.80. Determinants of agreement were higher education (better) and longer time between reports (worse). Conclusions: Information on in utero exposure to maternal tobacco smoking provided by adult women was highly reproducible in this population. JF - Annals of Epidemiology AU - Cupul-Uicab, Lea A AU - Ye, Xibiao AU - Skjaerven, Rolv AU - Haug, Kjell AU - Longnecker, Matthew P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Human and Health Services, USA, cupuluicabl@niehs.nih.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 48 EP - 52 PB - Elsevier Science, Box 882 New York NY 10159 USA VL - 21 IS - 1 SN - 1047-2797, 1047-2797 KW - Toxicology Abstracts KW - Education KW - Epidemiology KW - Fetuses KW - Gestation KW - Intrauterine exposure KW - Inventories KW - Pregnancy KW - Smoke KW - Statistics KW - Tobacco smoking KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1093430958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Reproducibility+of+Reported+In+Utero+Exposure+to+Tobacco+Smoke&rft.au=Cupul-Uicab%2C+Lea+A%3BYe%2C+Xibiao%3BSkjaerven%2C+Rolv%3BHaug%2C+Kjell%3BLongnecker%2C+Matthew+P&rft.aulast=Cupul-Uicab&rft.aufirst=Lea&rft.date=2011-01-01&rft.volume=21&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2010.10.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2012-10-08 N1 - SubjectsTermNotLitGenreText - Smoke; Inventories; Tobacco smoking; Education; Statistics; Epidemiology; Gestation; Intrauterine exposure; Fetuses; Pregnancy DO - http://dx.doi.org/10.1016/j.annepidem.2010.10.008 ER - TY - JOUR T1 - The Roles of IL-6, IL-10, and IL-1RA in Obesity and Insulin Resistance in African-Americans AN - 1034814761; 16109407 AB - OBJECTIVE: The aim of the study was to investigate the associations between IL-1 receptor antagonist (IL-1RA), IL-6, IL-10, measures of obesity, and insulin resistance in African-Americans. RESEARCH DESIGN AND METHODS: Nondiabetic participants (n = 1025) of the Howard University Family Study were investigated for associations between serum IL (IL-1RA, IL-6, IL-10), measures of obesity, and insulin resistance, with adjustment for age and sex. Measures of obesity included body mass index, waist circumference, hip circumference, waist-to-hip ratio, and percent fat mass. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR). Data were analyzed with R statistical software using linear regression and likelihood ratio tests. RESULTS: IL-1RA and IL-6 were associated with measures of obesity and insulin resistance, explaining 4-12.7% of the variance observed (P values < 0.001). IL-1RA was bimodally distributed and therefore was analyzed based on grouping those with low vs. high IL-1RA levels. High IL-1RA explained up to 20 and 12% of the variance in measures of obesity and HOMA-IR, respectively. Among the IL, only high IL-1RA improved the fit of models regressing HOMA-IR on measures of obesity. In contrast, all measures of obesity improved the fit of models regressing HOMA-IR on IL. IL-10 was not associated with obesity measures or HOMA-IR. CONCLUSIONS: High IL-1RA levels and obesity measures are associated with HOMA-IR in this population-based sample of African-Americans. The results suggest that obesity and increased levels of IL-1RA both contribute to the development of insulin resistance. JF - Journal of Clinical Endocrinology and Metabolism AU - Charles, Bashira A AU - Doumatey, Ayo AU - Huang, Hanxia AU - Zhou, Jie AU - Chen, Guanjie AU - Shriner, Daniel AU - Adeyemo, Adebowale AU - Rotimi, Charles N AD - Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892-5635 Y1 - 2011 PY - 2011 DA - 2011 SP - E2018 EP - E2022 PB - Endocrine Society, 4350 East West Highway Bethesda MD 20814-4426 United States VL - 96 IS - 12 SN - 0021-972X, 0021-972X KW - Physical Education Index KW - Analysis KW - Blood KW - Computers KW - Evaluation KW - Family KW - Hips KW - Hormones KW - Obesity KW - Research (statistical design) KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034814761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.atitle=The+Roles+of+IL-6%2C+IL-10%2C+and+IL-1RA+in+Obesity+and+Insulin+Resistance+in+African-Americans&rft.au=Charles%2C+Bashira+A%3BDoumatey%2C+Ayo%3BHuang%2C+Hanxia%3BZhou%2C+Jie%3BChen%2C+Guanjie%3BShriner%2C+Daniel%3BAdeyemo%2C+Adebowale%3BRotimi%2C+Charles+N&rft.aulast=Charles&rft.aufirst=Bashira&rft.date=2011-01-01&rft.volume=96&rft.issue=12&rft.spage=E2018&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2012-08-01 N1 - Last updated - 2012-08-24 N1 - SubjectsTermNotLitGenreText - Evaluation; Blood; Obesity; Research (statistical design); Computers; Analysis; Family; Hormones; Hips ER - TY - JOUR T1 - Developmental exposure to endocrine-disrupting chemicals programs for reproductive tract alterations and obesity later in life AN - 1034811668; 16079731 AB - Many chemicals in the environment, especially those with estrogenic activity, are able to disrupt the programming of endocrine signaling pathways established during development; these chemicals are referred to as endocrine-disrupting chemicals. Altered programming can result in numerous adverse consequences in estrogen-target tissues, some of which may not be apparent until later in life. For example, a wide variety of structural, functional, and cellular effects have been identified in reproductive tract tissues. In addition to well-documented reproductive changes, obesity and diabetes have joined the list of adverse effects that have been associated with developmental exposure to environmental estrogens and other endocrine-disrupting chemicals. Obesity is a significant public health problem reaching epidemic proportions worldwide. Experimental animal studies document an association of developmental exposure to environmental estrogens and obesity. For example, a murine model of perinatal exposure to diethylstilbestrol has proven useful in studying mechanisms involved in abnormal programming of differentiating estrogen-target tissues, including reproductive tract tissues and adipocytes. Other environmental estrogens, including the environmental contaminant bisphenol A, have also been linked to reproductive problems and obesity later in life. Epidemiology studies support similar findings in humans, as do studies of cells in culture. Together, these findings suggest new targets for abnormal programming by estrogenic chemicals and provide evidence supporting the scientific concept termed the developmental origins of adult disease. Furthermore, the association of environmental estrogens with obesity and diabetes expands the focus on these diseases from intervention or treatment to include prevention or avoidance of chemical modifiers, especially during critical windows of development. JF - American Journal of Clinical Nutrition AU - Newbold, Retha R AD - From the National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC Y1 - 2011 PY - 2011 DA - 2011 SP - 1939S EP - 1942S PB - American Society for Clinical Nutrition, 3247 Meyer Hall, University of California Davis CA 95616-8790 United States VL - 94 IS - 6 SN - 0002-9165, 0002-9165 KW - Physical Education Index KW - Basic instruction program KW - Culture KW - Diabetes KW - Diseases KW - Estrogen KW - Obesity KW - Preventive health KW - Programs KW - Public health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034811668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Clinical+Nutrition&rft.atitle=Developmental+exposure+to+endocrine-disrupting+chemicals+programs+for+reproductive+tract+alterations+and+obesity+later+in+life&rft.au=Newbold%2C+Retha+R&rft.aulast=Newbold&rft.aufirst=Retha&rft.date=2011-01-01&rft.volume=94&rft.issue=6&rft.spage=1939S&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Clinical+Nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2012-08-01 N1 - Last updated - 2012-08-24 N1 - SubjectsTermNotLitGenreText - Obesity; Culture; Programs; Preventive health; Estrogen; Basic instruction program; Diseases; Public health; Diabetes ER - TY - JOUR T1 - Risk Factors for Hearing Impairment Among U.S. Adults With Diabetes: National Health and Nutrition Examination Survey 1999-2004 AN - 1032898887; 15089150 AB - OBJECTIVE: The objective of this study was to examine the risk factors of low/mid-frequency and high-frequency hearing impairment among a nationally representative sample of diabetic adults. RESEARCH DESIGN AND METHODS: Data came from 536 participants, aged 20-69 years, with diagnosed or undiagnosed diabetes who completed audiometric testing during 1999-2004 in the National Health and Nutrition Examination Survey (NHANES). We defined hearing impairment as the pure-tone average >25 dB hearing level of pure-tone thresholds at low/mid-frequencies (500; 1,000; and 2,000 Hz) and high frequencies (3,000; 4,000; 6,000; and 8,000 Hz) and identified independent risk factors using logistic regression. RESULTS: Controlling for age, race/ethnicity, and marital status, odds ratios for associations with low/mid-frequency hearing impairment were 2.20 (95% CI 1.28-3.79) for HDL CONCLUSIONS: Low HDL, coronary heart disease, peripheral neuropathy, and having poor health are potentially preventable correlates of hearing impairment for people with diabetes. Glycemic control, years since diagnosis, and type of glycemic medication were not associated with hearing impairment. JF - Diabetes Care AU - Bainbridge, Kathleen E AU - Hoffman, Howard J AU - Cowie, Catherine C AD - Epidemiology and Statistics Program, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 1540 EP - 1545 PB - American Diabetes Association, 1701 N. Beauregard St. Alexandria VA 22311 USA VL - 34 IS - 7 SN - 0149-5992, 0149-5992 KW - Health & Safety Science Abstracts KW - Diabetes mellitus KW - USA KW - Age KW - Risk factors KW - Research design KW - Marriage KW - Hearing loss KW - Cardiovascular diseases KW - Nutrition KW - Ethnic groups KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1032898887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+Care&rft.atitle=Risk+Factors+for+Hearing+Impairment+Among+U.S.+Adults+With+Diabetes%3A+National+Health+and+Nutrition+Examination+Survey+1999-2004&rft.au=Bainbridge%2C+Kathleen+E%3BHoffman%2C+Howard+J%3BCowie%2C+Catherine+C&rft.aulast=Bainbridge&rft.aufirst=Kathleen&rft.date=2011-01-01&rft.volume=34&rft.issue=7&rft.spage=1540&rft.isbn=&rft.btitle=&rft.title=Diabetes+Care&rft.issn=01495992&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Age; Risk factors; Research design; Marriage; Cardiovascular diseases; Hearing loss; Nutrition; Ethnic groups; USA ER - TY - JOUR T1 - Adolescent and mid-life diet: risk of colorectal cancer in the NIH-AARP Diet and Health Study AN - 1032898859; 16079782 AB - BACKGROUND: Colorectal cancer has a natural history of several decades; therefore, the diet consumed decades before diagnosis may aid in understanding this malignancy. OBJECTIVE: The objective was to investigate diet during adolescence and 10 y before baseline (ages 40-61 y) in relation to colorectal cancer. DESIGN: Participants in the NIH-AARP Diet and Health Study (n = 292,797) completed a 124-item food-frequency questionnaire (FFQ) about diet in the past 12 mo and two 37-item FFQs about diet at ages 12-13 y and 10 y previously. Cox regression was used to estimate multivariate HRs and 95% CIs for colon (n = 2794) and rectal (n = 979) cancers within quintiles of exposures. RESULTS: Colon cancer risk was lower in the highest than in the lowest quintile of vitamin A (HR: 0.82; 95% CI: 0.72, 0.92) and vegetable (HR: 0.81, 0.70, 0.92) intakes during adolescence. Those in the highest intake category 10 y previously for calcium (HR: 0.83; 95% CI: 0.73, 0.94), vitamin A (HR: 0.81; 95% CI: 0.71, 0.92), vitamin C (HR: 0.83; 95% CI: 0.72, 0.95), fruit (HR: 0.84; 95% CI: 0.73, 0.97), and milk (HR: 0.78; 95% CI: 0.67, 0.90) had a lower risk of colon cancer, but a higher risk was observed for total fat (HR: 1.15; 95% CI: 1.01, 1.30), red meat (HR: 1.31; 95% CI: 1.12, 1.53), and processed meat (HR: 1.24; 95% CI: 1.06, 1.45). For rectal cancer, milk was inversely associated (HR: 0.75; 95% CI: 0.58, 0.96) with risk. CONCLUSION: Adolescent and midlife diet may play a role in colorectal carcinogenesis. JF - American Journal of Clinical Nutrition AU - Ruder, Elizabeth H AU - Thiebaut, Anne CM AU - Thompson, Frances E AU - Potischman, Nancy AU - Subar, Amy F AU - Park, Yikyung AU - Graubard, Barry I AU - Hollenbeck, Albert R AU - Cross, Amanda J AD - From the Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD (EHR, YP, BIG, and AJC) Y1 - 2011 PY - 2011 DA - 2011 SP - 1607 EP - 1619 PB - American Society for Clinical Nutrition, 3247 Meyer Hall, University of California Davis CA 95616-8790 United States VL - 94 IS - 6 SN - 0002-9165, 0002-9165 KW - Health & Safety Science Abstracts KW - Adolescents KW - Age KW - Cancer KW - Colorectal carcinoma KW - Diets KW - Fruits KW - Meat KW - Milk KW - Vitamins KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1032898859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Clinical+Nutrition&rft.atitle=Adolescent+and+mid-life+diet%3A+risk+of+colorectal+cancer+in+the+NIH-AARP+Diet+and+Health+Study&rft.au=Ruder%2C+Elizabeth+H%3BThiebaut%2C+Anne+CM%3BThompson%2C+Frances+E%3BPotischman%2C+Nancy%3BSubar%2C+Amy+F%3BPark%2C+Yikyung%3BGraubard%2C+Barry+I%3BHollenbeck%2C+Albert+R%3BCross%2C+Amanda+J&rft.aulast=Ruder&rft.aufirst=Elizabeth&rft.date=2011-01-01&rft.volume=94&rft.issue=6&rft.spage=1607&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Clinical+Nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Last updated - 2012-08-24 N1 - SubjectsTermNotLitGenreText - Meat; Diets; Fruits; Age; Milk; Vitamins; Colorectal carcinoma; Adolescents; Cancer ER - TY - JOUR T1 - Cross-Cultural Cognitive Interviewing: Seeking Comparability and Enhancing Understanding AN - 1030869591; 201228085 AB - Cognitive interviewing (CI) has emerged as a key qualitative method for the pretesting and evaluation of self-report survey questionnaires. This article defines CI, describes its key features, and outlines the data analysis techniques that are commonly used. The authors then consider recent extensions of cognitive testing to the cross-cultural survey research realm, where the major practical objectives are: (1) to facilitate inclusion of a range of cultural and linguistic groups and (2) for purposes of comparative analysis, to produce survey questionnaire items that exhibit comparability of measurement, across groups. Challenges presented by this extension to the cross-cultural and multilingual areas are discussed. Finally, the authors introduce the articles contained within the current special issue of Field Methods (2011), which endeavor to apply cognitive testing in specific cross-cultural survey projects, and to both identify and suggest solutions to the unique problems that face questionnaire designers and researchers more generally, in the practice of survey pretesting and evaluation methods as these endeavor to cover the sociocultural spectrum. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Field Methods AU - Willis, Gordon B AU - Miller, Kristen AD - National Cancer Institute, National Institutes of Health, Bethesda, MD, USA willisg@mail.nih.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 331 EP - 341 PB - Sage Publications, Thousand Oaks CA VL - 23 IS - 4 SN - 1525-822X, 1525-822X KW - cognitive interviewing cross-cultural research qualitative research questionnaire design survey pretesting KW - Comparative Analysis KW - Sociocultural Factors KW - Cultural Groups KW - Interviews KW - Linguistics KW - Crosscultural Differences KW - Cognition KW - article KW - 0514: culture and social structure; social anthropology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1030869591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Field+Methods&rft.atitle=Cross-Cultural+Cognitive+Interviewing%3A+Seeking+Comparability+and+Enhancing+Understanding&rft.au=Willis%2C+Gordon+B%3BMiller%2C+Kristen&rft.aulast=Willis&rft.aufirst=Gordon&rft.date=2011-01-01&rft.volume=23&rft.issue=4&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Field+Methods&rft.issn=1525822X&rft_id=info:doi/10.1177%2F1525822X11416092 LA - English DB - Sociological Abstracts N1 - Date revised - 2012-08-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Cognition; Crosscultural Differences; Interviews; Comparative Analysis; Linguistics; Sociocultural Factors; Cultural Groups DO - http://dx.doi.org/10.1177/1525822X11416092 ER - TY - JOUR T1 - Real-time PCR-based assay to quantify the relative amount of human and mouse tissue present in tumor xenografts AN - 1024668289; 16863417 AB - Background: Xenograft samples used to test anti-cancer drug efficacies and toxicities in vivo contain an unknown mix of mouse and human cells. Evaluation of drug activity can be confounded by samples containing large amounts of contaminating mouse tissue. We have developed a real-time quantitative polymerase chain reaction (qPCR) assay using TaqMan technology to quantify the amount of mouse tissue that is incorporated into human xenograft samples. Results: The forward and reverse primers bind to the same DNA sequence in the human and the mouse genome. Using a set of specially designed fluorescent probes provides species specificity. The linearity and sensitivity of the assay is evaluated using serial dilutions of single species and heterogeneous DNA mixtures. We examined many xenograft samples at various in vivo passages, finding a wide variety of human:mouse DNA ratios. This variation may be influenced by tumor type, number of serial passages in vivo, and even which part of the tumor was collected and used in the assay. Conclusions: This novel assay provides an accurate quantitative assessment of human and mouse content in xenograft tumors. This assay can be performed on aberrantly behaving human xenografts, samples used in bioinformatics studies, and periodically for tumor tissue frequently grown by serial passage in vivo. JF - BMC Biotechnology AU - Alcoser, Sergio Y AU - Kimmel, David J AU - Borgel, Suzanne D AU - Carter, John P AU - Dougherty, Kelly M AU - Hollingshead, Melinda G AD - Biological Testing Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick, Frederick, MD, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 124 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 11 IS - 1 SN - 1472-6750, 1472-6750 KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Nucleotide sequence KW - Fluorescent indicators KW - Polymerase chain reaction KW - Primers KW - Drug development KW - Xenografts KW - Tumors KW - Bioinformatics KW - Toxicity KW - Drugs KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1024668289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Biotechnology&rft.atitle=Real-time+PCR-based+assay+to+quantify+the+relative+amount+of+human+and+mouse+tissue+present+in+tumor+xenografts&rft.au=Alcoser%2C+Sergio+Y%3BKimmel%2C+David+J%3BBorgel%2C+Suzanne+D%3BCarter%2C+John+P%3BDougherty%2C+Kelly+M%3BHollingshead%2C+Melinda+G&rft.aulast=Alcoser&rft.aufirst=Sergio&rft.date=2011-01-01&rft.volume=11&rft.issue=1&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=BMC+Biotechnology&rft.issn=14726750&rft_id=info:doi/10.1186%2F1472-6750-11-124 L2 - http://www.biomedcentral.com/1472-6750/11/124 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Number of references - 24 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Genomes; Nucleotide sequence; Polymerase chain reaction; Fluorescent indicators; Drug development; Primers; Toxicity; Bioinformatics; Tumors; Xenografts; Drugs DO - http://dx.doi.org/10.1186/1472-6750-11-124 ER - TY - JOUR T1 - Directional gene expression and antisense transcripts in sexual and asexual stages of Plasmodium falciparum AN - 1024661301; 16856198 AB - Background: It has been shown that nearly a quarter of the initial predicted gene models in the Plasmodium falciparum genome contain errors. Although there have been efforts to obtain complete cDNA sequences to correct the errors, the coverage of cDNA sequences on the predicted genes is still incomplete, and many gene models for those expressed in sexual or mosquito stages have not been validated. Antisense transcripts have widely been reported in P. falciparum; however, the extent and pattern of antisense transcripts in different developmental stages remain largely unknown. Results: We have sequenced seven bidirectional libraries from ring, early and late trophozoite, schizont, gametocyte II, gametocyte V, and ookinete, and four strand-specific libraries from late trophozoite, schizont, gametocyte II, and gametocyte V of the 3D7 parasites. Alignment of the cDNA sequences to the 3D7 reference genome revealed stage-specific antisense transcripts and novel intron-exon splicing junctions. Sequencing of strand-specific cDNA libraries suggested that more genes are expressed in one direction in gametocyte than in schizont. Alternatively spliced genes, antisense transcripts, and stage-specific expressed genes were also characterized. Conclusions: It is necessary to continue to sequence cDNA from different developmental stages, particularly those of non-erythrocytic stages. The presence of antisense transcripts in some gametocyte and ookinete genes suggests that these antisense RNA may play an important role in gene expression regulation and parasite development. Future gene expression studies should make use of directional cDNA libraries. Antisense transcripts may partly explain the observed discrepancy between levels of mRNA and protein expression. JF - BMC Genomics AU - Lopez-Barragan, Maria J AU - Lemieux, Jacob AU - Quinones, Mariam AU - Williamson, Kim C AU - Molina-Cruz, Alvaro AU - Cui, Kairong AU - Barillas-Mury, Carolina AU - Zhao, Keji AU - Su, Xin-zhuan AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 587 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 12 IS - 1 SN - 1471-2164, 1471-2164 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts C: Algology, Mycology & Protozoology; Genetics Abstracts KW - Genomes KW - Parasites KW - Gametocytes KW - Zygotes KW - Antisense RNA KW - Schizonts KW - Developmental stages KW - Plasmodium falciparum KW - Models KW - Alternative splicing KW - Gene expression KW - DNA KW - Aquatic insects KW - Trophozoites KW - G 07790:Other Microorganisms KW - W 30940:Products KW - Q1 08484:Species interactions: parasites and diseases KW - N 14830:RNA KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1024661301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Genomics&rft.atitle=Directional+gene+expression+and+antisense+transcripts+in+sexual+and+asexual+stages+of+Plasmodium+falciparum&rft.au=Lopez-Barragan%2C+Maria+J%3BLemieux%2C+Jacob%3BQuinones%2C+Mariam%3BWilliamson%2C+Kim+C%3BMolina-Cruz%2C+Alvaro%3BCui%2C+Kairong%3BBarillas-Mury%2C+Carolina%3BZhao%2C+Keji%3BSu%2C+Xin-zhuan&rft.aulast=Lopez-Barragan&rft.aufirst=Maria&rft.date=2011-01-01&rft.volume=12&rft.issue=1&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=BMC+Genomics&rft.issn=14712164&rft_id=info:doi/10.1186%2F1471-2164-12-587 L2 - http://www.biomedcentral.com/1471-2164/12/587 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Number of references - 47 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Genomes; Gene expression; Parasites; DNA; Aquatic insects; Gametocytes; Zygotes; Antisense RNA; Developmental stages; Schizonts; Alternative splicing; Trophozoites; Models; Plasmodium falciparum DO - http://dx.doi.org/10.1186/1471-2164-12-587 ER - TY - JOUR T1 - An insight into the sialome of Simulium guianense (DIPTERA:SIMulIIDAE), the main vector of River Blindness Disease in Brazil AN - 1024661181; 16856223 AB - Background: Little is known about the composition and function of the saliva in black flies such as Simulium guianense, the main vector of river blindness disease in Brazil. The complex salivary potion of hematophagous arthropods counteracts their host's hemostasis, inflammation, and immunity. Results: Transcriptome analysis revealed ubiquitous salivary protein families--such as the Antigen-5, Yellow, Kunitz domain, and serine proteases--in the S. guianense sialotranscriptome. Insect-specific families were also found. About 63.4% of all secreted products revealed protein families found only in Simulium. Additionally, we found a novel peptide similar to kunitoxin with a structure distantly related to serine protease inhibitors. This study revealed a relative increase of transcripts of the SVEP protein family when compared with Simulium vittatum and S. nigrimanum sialotranscriptomes. We were able to extract coding sequences from 164 proteins associated with blood and sugar feeding, the majority of which were confirmed by proteome analysis. Conclusions: Our results contribute to understanding the role of Simulium saliva in transmission of Onchocerca volvulus and evolution of salivary proteins in black flies. It also consists of a platform for mining novel anti-hemostatic compounds, vaccine candidates against filariasis, and immuno-epidemiologic markers of vector exposure. JF - BMC Genomics AU - Chagas, Andrezza C AU - Calvo, Eric AU - Pimenta, Paulo FP AU - Ribeiro, Jose MC AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, 12735 Twinbrook Parkway, National Institutes of Health, Rockville, Maryland 20892-8132, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 612 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 12 IS - 1 SN - 1471-2164, 1471-2164 KW - Aqualine Abstracts; Water Resources Abstracts; Entomology Abstracts; Genetics Abstracts KW - Blood KW - Arthropoda KW - Proteins KW - Vectors KW - G:07810 KW - SW 5010:Network design KW - Z:05360 KW - AQ 00008:Effects of Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1024661181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Genomics&rft.atitle=An+insight+into+the+sialome+of+Simulium+guianense+%28DIPTERA%3ASIMulIIDAE%29%2C+the+main+vector+of+River+Blindness+Disease+in+Brazil&rft.au=Chagas%2C+Andrezza+C%3BCalvo%2C+Eric%3BPimenta%2C+Paulo+FP%3BRibeiro%2C+Jose+MC&rft.aulast=Chagas&rft.aufirst=Andrezza&rft.date=2011-01-01&rft.volume=12&rft.issue=1&rft.spage=612&rft.isbn=&rft.btitle=&rft.title=BMC+Genomics&rft.issn=14712164&rft_id=info:doi/10.1186%2F1471-2164-12-612 L2 - http://www.biomedcentral.com/1471-2164/12/612 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Vectors; Proteins; Arthropoda DO - http://dx.doi.org/10.1186/1471-2164-12-612 ER - TY - JOUR T1 - Model Project of Home-Visit Living-Skills Coaching for Individuals with Severe Mental Illness in Japan AN - 1023094811; 201219613 AB - In Japan in 2005, a service called Home- Visit Living-Skills Coaching was legislated. However, this service is not disseminated, and the specific service contents, service effects, and running cost are still unclear. Therefore, we describe the service content and actual condition and evaluate the service effect. The number of inpatient days was evaluated at baseline, 6 months, and 12 months. Methods: The Home-Visit Living-Skills Coaching project was executed by three welfare agencies in Ichikawa City from January 2008 to March 2009. The participants included in this study were individuals with severe mental illness in Ichikawa (n = 33). We recorded every visiting contact with participants by using a service-code checklist for a one-year implementation period (January 2008-March 2009). Results: We clarified that Home-Visit Living-Skills Coaching covers multiple needs of participants in their community lives. The percentage of daily household tasks represented only 23.2 percent of total service content checks. In this service, completing tasks for clients or helping clients directly was not the primary method, but the goal was, instead, to advise clients and to improve their skills. Thus, this service requires more expert knowledge and skills relevant to mental health for practitioners than just household assistance knowledge and skills. The Home- Visit Life Coaching service may have a positive influence as reflected by the reduction in the number of hospital days when compared with the preimplementation period. Conclusion: The Home- Visit Living. Adapted from the source document. JF - International Journal of Mental Health AU - Yoshida, Koji AU - Ito, Junichiro AU - Ogawa, Masayo AD - Section Chief of Clinical Practice Research, Department of Psychiatric Rehabilitation, National Institute of Mental Health. National Center of Neurology and Psychiatry, Tokyo Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 19 EP - 27 PB - M.E. Sharpe, Armonk NY VL - 40 IS - 4 SN - 0020-7411, 0020-7411 KW - Goals KW - Mentally ill people KW - Coaching KW - Households KW - Japan KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023094811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Mental+Health&rft.atitle=Model+Project+of+Home-Visit+Living-Skills+Coaching+for+Individuals+with+Severe+Mental+Illness+in+Japan&rft.au=Yoshida%2C+Koji%3BIto%2C+Junichiro%3BOgawa%2C+Masayo&rft.aulast=Yoshida&rft.aufirst=Koji&rft.date=2011-01-01&rft.volume=40&rft.issue=4&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Mental+Health&rft.issn=00207411&rft_id=info:doi/10.2753%2FIMH0020-7411400402 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Coaching; Mentally ill people; Japan; Households; Hospitals; Goals DO - http://dx.doi.org/10.2753/IMH0020-7411400402 ER - TY - JOUR T1 - That which We Call a Rose by any Other Name Would Sound as Sweet: Folk perceptions, status and language variation AN - 1023037937; 201209123 AB - Folk perceptions of language diversity often differ from the criteria laid out by linguists and have particular implications for applied/sociolinguists since the collective identification of language diversity largely determines the ways in which individuals regard the categorisation of their own (and others) linguistic uses as belonging to a specific social and/or regional variety. Folk perceptions can thus help define speech communities as well as explain sociolinguistic other phenomena. This paper provides a critical analysis of the existing folk linguistic research into language variation in a number of different contexts: the UK, the USA, France and Japan. It is hoped that the information gained will help build up a more detailed sociolinguistic picture of the complex and often contradictory nature of lay individuals' attitudes towards linguistic variation. In the final sections of the paper the authors argue for a greater deal of recognition within modern linguistics of the value of examining folk perceptions of language diversity. Adapted from the source document JF - AILA Review AU - McKenzie, Robert M AU - Osthus, Dietmar AD - English Language and Linguistics, Northumbria University, Newcastle upon Tyne NEI 8ST, UK robert.mckenzie@northumbria.ac.uk Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 100 EP - 115 VL - 24 SN - 1461-0213, 1461-0213 KW - Beliefs (08100) KW - France (25500) KW - United Kingdom (92700) KW - Folk Linguistics (24942) KW - Language Diversity (42350) KW - United States of America (92750) KW - Applied Linguistics (03500) KW - Japan (39400) KW - Sociolinguistics (80200) KW - Speech Communities (82410) KW - article KW - 5610: sociolinguistics; sociolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023037937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AILA+Review&rft.atitle=That+which+We+Call+a+Rose+by+any+Other+Name+Would+Sound+as+Sweet%3A+Folk+perceptions%2C+status+and+language+variation&rft.au=McKenzie%2C+Robert+M%3BOsthus%2C+Dietmar&rft.aulast=McKenzie&rft.aufirst=Robert&rft.date=2011-01-01&rft.volume=24&rft.issue=&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=AILA+Review&rft.issn=14610213&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AILREW N1 - SubjectsTermNotLitGenreText - Language Diversity (42350); Folk Linguistics (24942); Beliefs (08100); Applied Linguistics (03500); Speech Communities (82410); Sociolinguistics (80200); United Kingdom (92700); United States of America (92750); France (25500); Japan (39400) ER - TY - JOUR T1 - Evaluation of a Radionovela to Promote HPV Vaccine Awareness and Knowledge Among Hispanic Parents AN - 1018338844; 201202582 AB - Hispanic women have more than a 1.5-fold increased cervical cancer incidence and mortality compared to non-Hispanic white women in the United States. The Centers for Disease Control recommends the HPV vaccine for females at ages 11 and 12 years, though it is approved for females aged 9-26 to protect against the primary types of high-risk HPV (HPV-16 and HPV-18) that cause approximately 70% of cervical cancer cases. Few culturally-tailored Spanish HPV vaccine awareness programs have been developed. This study evaluates the efficacy of a Spanish radionovela as an educational tool. Rural Hispanic parents of daughters aged 9-17 (n = 88; 78 mothers and 10 fathers) were randomized to listen to the HPV vaccine radionovela or to another public service announcement. Participants completed a 30 min pretest posttest questionnaire. Parents who listened to the HPV radionovela (intervention group) scored higher on six knowledge and belief items. They were more likely to confirm that HPV is a common infection (70% vs. 48%, P = .002), to deny that women are able to detect HPV (53% vs. 31%, P = .003), to know vaccine age recommendations (87% vs. 68%, P = .003), and to confirm multiple doses (48% vs. 26%, P = .03) than control group parents. The HPV vaccine radionovela improved HPV and HPV vaccine knowledge and attitudes. Radionovela health education may be an efficacious strategy to increase HPV vaccine awareness among Hispanic parents. Adapted from the source document. JF - Journal of Community Health AU - Kepka, Deanna AU - Coronado, Gloria D AU - Rodriguez, Hector P AU - Thompson, Beti AD - National Cancer Institute, Executive Plaza South, Suite 150E, 6120 Executive Blvd., MSC 7105, Rockville, MD, 20892-7105, USA deanna.kepka@nih.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 957 EP - 965 PB - Springer, New York NY VL - 36 IS - 6 SN - 0094-5145, 0094-5145 KW - Consciousness KW - Mortality Rates KW - Hispanic Americans KW - Females KW - Parents KW - Vaccination KW - Cancer KW - Knowledge KW - Health Care Services KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018338844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=Evaluation+of+a+Radionovela+to+Promote+HPV+Vaccine+Awareness+and+Knowledge+Among+Hispanic+Parents&rft.au=Kepka%2C+Deanna%3BCoronado%2C+Gloria+D%3BRodriguez%2C+Hector+P%3BThompson%2C+Beti&rft.aulast=Kepka&rft.aufirst=Deanna&rft.date=2011-01-01&rft.volume=36&rft.issue=6&rft.spage=957&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-011-9395-1 LA - English DB - Social Services Abstracts N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JCMHBR N1 - SubjectsTermNotLitGenreText - Vaccination; Parents; Hispanic Americans; Females; Knowledge; Consciousness; Cancer; Health Care Services; Mortality Rates DO - http://dx.doi.org/10.1007/s10900-011-9395-1 ER - TY - JOUR T1 - Radiation-Related Cancer Risks From CT Colonography Screening: A Risk-Benefit Analysis AN - 1017985647; 14592167 AB - OBJECTIVE: The purpose of this study was to estimate the ratio of cancers prevented to induced (benefit-risk ratio) for CT colonography (CTC) screening every 5 years from the age of 50 to 80 years. MATERIALS AND METHODS: Radiation-related cancer risk was estimated using risk projection models based on the National Research Council's Biological Effects of Ionizing Radiation (BEIR) VII Committee's report and screening protocols from the American College of Radiology Imaging Network's National CT Colonography Trial. Uncertainty intervals were estimated using Monte Carlo simulation methods. Comparative modeling with three colorectal cancer microsimulation models was used to estimate the potential reduction in colorectal cancer cases and deaths. RESULTS: The estimated mean effective dose per CTC screening study was 8 mSv for women and 7 mSv for men. The estimated number of radiation-related cancers resulting from CTC screening every 5 years from the age of 50 to 80 years was 150 cases/100,000 individuals screened (95% uncertainty interval, 80-280) for men and women. The estimated number of colorectal cancers prevented by CTC every 5 years from age 50 to 80 ranged across the three microsimulation models from 3580 to 5190 cases/100,000 individuals screened, yielding a benefit-risk ratio that varied from 24:1 (95% uncertainty interval, 13:1-45:1) to 35:1 (19:1-65:1). The benefit-risk ratio for cancer deaths was even higher than the ratio for cancer cases. Inclusion of radiation-related cancer risks from CT examinations performed to follow up extracolonic findings did not materially alter the results. CONCLUSION: Concerns have been raised about recommending CTC as a routine screening tool because of potential harms including the radiation risks. Based on these models, the benefits from CTC screening every 5 years from the age of 50 to 80 years clearly outweigh the radiation risks. JF - American Journal of Roentgenology AU - de Gonzalez, Amy Berrington AU - Kim, Kwang Pyo AU - Knudsen, Amy B AU - Lansdorp-Vogelaar, Iris AU - Rutter, Carolyn M AU - Smith-Bindman, Rebecca AU - Yee, Judy AU - Kuntz, Karen M AU - van Ballegooijen, Marjolein AU - Zauber, Ann G AU - Berg, Christine D AD - Division of Cancer Epidemiology & Genetics, National Cancer Institute,6120 Executive Blvd, Bethesda, MD 20892 Y1 - 2011 PY - 2011 DA - 2011 SP - 816 EP - 823 PB - American Roentgen Ray Society VL - 196 IS - 4 SN - 0361-803X, 0361-803X KW - Toxicology Abstracts KW - Age KW - Colorectal cancer KW - Computed tomography KW - Ionizing radiation KW - Models KW - Monte Carlo simulation KW - Radiology KW - Risk assessment KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017985647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Roentgenology&rft.atitle=Radiation-Related+Cancer+Risks+From+CT+Colonography+Screening%3A+A+Risk-Benefit+Analysis&rft.au=de+Gonzalez%2C+Amy+Berrington%3BKim%2C+Kwang+Pyo%3BKnudsen%2C+Amy+B%3BLansdorp-Vogelaar%2C+Iris%3BRutter%2C+Carolyn+M%3BSmith-Bindman%2C+Rebecca%3BYee%2C+Judy%3BKuntz%2C+Karen+M%3Bvan+Ballegooijen%2C+Marjolein%3BZauber%2C+Ann+G%3BBerg%2C+Christine+D&rft.aulast=de+Gonzalez&rft.aufirst=Amy&rft.date=2011-01-01&rft.volume=196&rft.issue=4&rft.spage=816&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Roentgenology&rft.issn=0361803X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Risk assessment; Monte Carlo simulation; Age; Ionizing radiation; Computed tomography; Colorectal cancer; Radiology; Models ER - TY - JOUR T1 - Dietary Supplement Use in the United States, 2003-2006 AN - 1017984405; 14266754 AB - Dietary supplement use has steadily increased over time since the 1970s; however, no current data exist for the U.S. population. Therefore, the purpose of this analysis was to estimate dietary supplement use using the NHANES 2003-2006, a nationally representative, cross-sectional survey. Dietary supplement use was analyzed for the U.S. population ( greater than or equal to 1 y of age) by the DRI age groupings. Supplement use was measured through a questionnaire and was reported by 49% of the U.S. population (44% of males, 53% of females). Multivitamin-multimineral use was the most frequently reported dietary supplement (33%). The majority of people reported taking only 1 dietary supplement and did so on a daily basis. Dietary supplement use was lowest in obese adults and highest among non-Hispanic whites, older adults, and those with more than a high-school education. Between 28 and 30% reported using dietary supplements containing vitamins B-6, B-12, C, A, and E; 18-19% reported using iron, selenium, and chromium; and 26-27% reported using zinc- and magnesium-containing supplements. Botanical supplement use was more common in older than in younger age groups and was lowest in those aged 1-13 y but was reported by approximately 20% of adults. About one-half of the U.S. population and 70% of adults greater than or equal to 71 y use dietary supplements; one-third use multivitamin-multimineral dietary supplements. Given the widespread use of supplements, data should be included with nutrient intakes from foods to correctly determine total nutrient exposure. JF - Journal of Nutrition AU - Bailey, Regan L AU - Gahche, Jaime J AU - Lentino, Cindy V AU - Dwyer, Johanna T AU - Engel, Jody S AU - Thomas, Paul R AU - Betz, Joseph M AU - Sempos, Christopher T AU - Picciano, Mary Frances AD - National Institutes of Health, Office of Dietary Supplements, Bethesda, MD 20892-7517 Y1 - 2011 PY - 2011 DA - 2011 SP - 261 EP - 266 PB - American Society for Nutritional Sciences, 9650 Rockville Pike, Room L-2407A Bethesda MD 20814 USA VL - 141 IS - 2 SN - 0022-3166, 0022-3166 KW - Toxicology Abstracts KW - Age KW - Chromium KW - Data processing KW - Dietary supplements KW - Food KW - Inventories KW - Iron KW - Nutrients KW - Obesity KW - Selenium KW - Vitamins KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017984405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nutrition&rft.atitle=Dietary+Supplement+Use+in+the+United+States%2C+2003-2006&rft.au=Bailey%2C+Regan+L%3BGahche%2C+Jaime+J%3BLentino%2C+Cindy+V%3BDwyer%2C+Johanna+T%3BEngel%2C+Jody+S%3BThomas%2C+Paul+R%3BBetz%2C+Joseph+M%3BSempos%2C+Christopher+T%3BPicciano%2C+Mary+Frances&rft.aulast=Bailey&rft.aufirst=Regan&rft.date=2011-01-01&rft.volume=141&rft.issue=2&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Selenium; Inventories; Obesity; Age; Data processing; Chromium; Food; Vitamins; Dietary supplements; Nutrients; Iron ER - TY - JOUR T1 - Can Radiation Risks to Patients Be Reduced Without Reducing Radiation Exposure? The Status of Chemical Radioprotectants AN - 1017982284; 14403621 AB - OBJECTIVE: Medical radiation exposure has increased sixfold since 1980 and is the largest controllable source of exposure. Many efforts have been devoted to reducing dose or eliminating unnecessary examinations but with limited success. The concern regarding nuclear terrorism has focused a large amount of attention on radioprotective drugs. The purpose of this article is twofold: to review the current concepts, potential, and limitations of chemical radioprotectants in reducing stochastic and deterministic effects and to assess the potential application to diagnostic and interventional medical radiation procedures. CONCLUSION: There are a wide variety of chemical compounds that have been studied for radioprotective effects. Although there is promising research, chemical radioprotectants have not been shown to be very effective and, with one limited exception, are not the standard of care in medicine. JF - American Journal of Roentgenology AU - Mettler, Fred A AU - Brenner, David AU - Coleman, CNorman AU - Kaminski, Joseph M AU - Kennedy, Ann R AU - Wagner, Louis K AD - Department of Radiology and Nuclear Medicine Service, New Mexico VA HealthCare Services, 1501 San Pedro Blvd. SE, Albuquerque, NM 87108. Department of Radiology, Columbia University, New York, NY. Department of Radiology, National Cancer Institute, National Institutes ofHealth, Rockville, MD. Division of Medical Imaging Products, Center for Drug Evaluation and Research,U.S. Food and Drug Administration, Silver Spring, MD. Department of Radiation Oncology, University of Pennsylvania School ofMedicine, Philadelphia, PA. Department of Radiology, University of Texas-Houston Medical School,Houston, TX. Y1 - 2011 PY - 2011 DA - 2011 SP - 616 EP - 618 PB - American Roentgen Ray Society VL - 196 IS - 3 SN - 0361-803X, 0361-803X KW - Toxicology Abstracts KW - Drugs KW - Radiation KW - Reviews KW - Stochasticity KW - terrorism KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017982284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Roentgenology&rft.atitle=Can+Radiation+Risks+to+Patients+Be+Reduced+Without+Reducing+Radiation+Exposure%3F+The+Status+of+Chemical+Radioprotectants&rft.au=Mettler%2C+Fred+A%3BBrenner%2C+David%3BColeman%2C+CNorman%3BKaminski%2C+Joseph+M%3BKennedy%2C+Ann+R%3BWagner%2C+Louis+K&rft.aulast=Mettler&rft.aufirst=Fred&rft.date=2011-01-01&rft.volume=196&rft.issue=3&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Roentgenology&rft.issn=0361803X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - terrorism; Radiation; Reviews; Drugs; Stochasticity ER - TY - JOUR T1 - Relationship between blood and myocardium manganese levels during manganese-enhanced MRI (MEMRI) with T1 mapping in rats AN - 1017972473; 16700564 AB - Manganese ions (Mn2+) enter viable myocardial cells via voltage-gated calcium channels. Because of its shortening of T1 and its relatively long half-life in cells, Mn2+ can serve as an intracellular molecular contrast agent to study indirect calcium influx into the myocardium. One major concern in using Mn2+ is its sensitivity over a limited range of concentrations employing T1-weighted images for visualization, which limits its potential in quantitative techniques. Therefore, this study assessed the implementation of a T1 mapping method for cardiac manganese-enhanced MRI to enable a quantitative estimate of the influx of Mn2+ over a wide range of concentrations in male Sprague-Dawley rats. This MRI method was used to compare the relationship between T1 changes in the heart as a function of myocardium and blood Mn2+ levels. Results showed a biphasic relationship between Delta *DR1 and the total Mn2+ infusion dose. Nonlinear relationships were observed between the total Mn2+ infusion dose versus blood levels and left ventricular free wall Delta *DR1. At low blood levels of Mn2+, there was proportionally less cardiac enhancement seen than at higher levels of blood Mn2+. We hypothesize that Mn2+ blood levels increase as a result of rate-limiting excretion by the liver and kidneys at these higher Mn2+ doses. JF - NMR in Biomedicine AU - Hu, Tom C-C AU - Chuang, Kai-Hsiang AU - Yanasak, Nathan AU - Koretsky, Alan AD - Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA, thu@mail.mcg.edu Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 46 EP - 53 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 24 IS - 1 SN - 1099-1492, 1099-1492 KW - Biotechnology and Bioengineering Abstracts KW - Blood levels KW - Calcium channels (voltage-gated) KW - Calcium influx KW - Contrast media KW - Excretion KW - Heart KW - Ions KW - Kidney KW - Liver KW - Magnetic resonance imaging KW - Manganese KW - Mapping KW - Myocardium KW - N.M.R. KW - Ventricle KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017972473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=Relationship+between+blood+and+myocardium+manganese+levels+during+manganese-enhanced+MRI+%28MEMRI%29+with+T1+mapping+in+rats&rft.au=Hu%2C+Tom+C-C%3BChuang%2C+Kai-Hsiang%3BYanasak%2C+Nathan%3BKoretsky%2C+Alan&rft.aulast=Hu&rft.aufirst=Tom&rft.date=2011-01-01&rft.volume=24&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=10991492&rft_id=info:doi/10.1002%2Fnbm.1554 L2 - http://onlinelibrary.wiley.com/doi/10.1002/nbm.1554/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Heart; Ions; Magnetic resonance imaging; Calcium channels (voltage-gated); Blood levels; Calcium influx; Ventricle; Kidney; Contrast media; Liver; Excretion; N.M.R.; Mapping; Manganese; Myocardium DO - http://dx.doi.org/10.1002/nbm.1554 ER - TY - JOUR T1 - Heavy metal contaminants can eliminate quantum dot fluorescence AN - 1017972246; 16714525 AB - Quantum dots (QD) are fluorescent nanocrystals that are highly useful in imaging and flow cytometric analyses. During routine use of monoclonal antibody conjugates of QD, we have occasionally seen partial or total loss of fluorescence when using certain lots of fixative solutions. We hypothesized that a low level contamination with heavy metal cations was responsible, since low level metal contaminants are not uncommon in formalin solutions. By titrating known concentrations of heavy metal cations into staining solutions, we found that millimolar concentrations of ferrous and zinc ions, and as low as 50 nanomolar cupric ions, completely eliminated QD fluorescence. By mass spectroscopic quantification of metals in commercial fixative solutions previously shown to perform poorly or well with regard to QD fluorescence, we confirmed that the presence of copper in solution was correlated with poor performance. Notably, prior addition of EDTA to chelate the divalent cations in these solutions prevented the inhibition of QD fluorescence. Finally, the copper-induced loss of QD fluorescence is irreversible: cells labeled with QD are highly fluorescent and can be rendered nonfluorescent by the addition of cupric sulfate, even after washing extensively. Indeed, these cells can then be successfully stained with other QD reagents, providing a method for immunofluorescence restaining of cells without contaminating fluorescence from the first stain. Published 2010 Wiley-Liss, Inc. JF - Cytometry Part A AU - Zarkowsky, David AU - Lamoreaux, Laurie AU - Chattopadhyay, Pratip AU - Koup, Richard A AU - Perfetto, Stephen P AU - Roederer, Mario AD - Laboratory of Immunology, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, Roederer@nih.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 84 EP - 89 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 79A IS - 1 SN - 1552-4930, 1552-4930 KW - Biotechnology and Bioengineering Abstracts KW - Cations KW - Chelates KW - Contaminants KW - Copper KW - Crystals KW - Cytometry KW - Edetic acid KW - Fixatives KW - Flow cytometry KW - Fluorescence KW - Heavy metals KW - Immunofluorescence KW - Ions KW - Monoclonal antibodies KW - Quantum dots KW - Stains KW - Zinc KW - cupric sulfate KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017972246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+A&rft.atitle=Heavy+metal+contaminants+can+eliminate+quantum+dot+fluorescence&rft.au=Zarkowsky%2C+David%3BLamoreaux%2C+Laurie%3BChattopadhyay%2C+Pratip%3BKoup%2C+Richard+A%3BPerfetto%2C+Stephen+P%3BRoederer%2C+Mario&rft.aulast=Zarkowsky&rft.aufirst=David&rft.date=2011-01-01&rft.volume=79A&rft.issue=1&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+A&rft.issn=15524930&rft_id=info:doi/10.1002%2Fcyto.a.20986 L2 - http://onlinelibrary.wiley.com/doi/10.1002/cyto.a.20986/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Ions; Fluorescence; Heavy metals; Monoclonal antibodies; cupric sulfate; Crystals; Immunofluorescence; Copper; Stains; imaging; Cytometry; Flow cytometry; Cations; Quantum dots; Fixatives; Zinc; Contaminants; Chelates; Edetic acid DO - http://dx.doi.org/10.1002/cyto.a.20986 ER - TY - JOUR T1 - From the black widow spider to human behavior: Latrophilins, a relatively unknown class of G protein-coupled receptors, are implicated in psychiatric disorders AN - 1017970990; 16714260 AB - The findings of a recent study associate LPHN3, a member of the latrophilin family, with an increased risk of developing attention deficit/hyperactivity disorder (ADHD), the most common psychiatric disorder in childhood and adolescence. Latrophilins comprise a new family of G protein-coupled receptors of unknown native physiological function that mediate the neurotoxic effects of -latrotoxin, a potent toxin found in black widow spider venom. This receptor-toxin interaction has helped to elucidate the mechanistic aspects of neurotransmitter and hormone release in vertebrates. Such unprecedented discovery points to a new direction in the assessment of ADHD and suggest that further study of this receptor family may provide novel insights into the etiology and treatment of ADHD and other related psychiatric conditions. copyright 2010 Wiley-Liss, Inc. JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics AU - Martinez, Ariel F AU - Muenke, Maximilian AU - Arcos-Burgos, Mauricio Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 1 EP - 10 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 156 IS - 1 SN - 1552-485X, 1552-485X KW - Entomology Abstracts; CSA Neurosciences Abstracts; Genetics Abstracts; Toxicology Abstracts KW - Adolescence KW - Attention deficit hyperactivity disorder KW - Children KW - Etiology KW - G protein-coupled receptors KW - Hormone release KW - Mental disorders KW - Neurotoxicity KW - Neurotransmitters KW - Toxins KW - Venom KW - Araneae KW - N3 11001:Behavioral and Cognitive Neuroscience KW - X 24370:Natural Toxins KW - G 07810:Insects KW - Z 05360:Genetics and Evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017970990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Medical+Genetics.+Part+B%3A+Neuropsychiatric+Genetics&rft.atitle=From+the+black+widow+spider+to+human+behavior%3A+Latrophilins%2C+a+relatively+unknown+class+of+G+protein-coupled+receptors%2C+are+implicated+in+psychiatric+disorders&rft.au=Martinez%2C+Ariel+F%3BMuenke%2C+Maximilian%3BArcos-Burgos%2C+Mauricio&rft.aulast=Martinez&rft.aufirst=Ariel&rft.date=2011-01-01&rft.volume=156&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Medical+Genetics.+Part+B%3A+Neuropsychiatric+Genetics&rft.issn=1552485X&rft_id=info:doi/10.1002%2Fajmg.b.31137 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ajmg.b.31137/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-02-08 N1 - SubjectsTermNotLitGenreText - Etiology; Mental disorders; G protein-coupled receptors; Hormone release; Adolescence; Neurotoxicity; Attention deficit hyperactivity disorder; Neurotransmitters; Children; Venom; Toxins; Araneae DO - http://dx.doi.org/10.1002/ajmg.b.31137 ER - TY - JOUR T1 - Anxiety in medically ill children/adolescents AN - 1017969138; 16706504 AB - Anxiety disorders are thought to be one of the most common psychiatric diagnoses in children/adolescents. Chronic medical illness is a significant risk factor for the development of an anxiety disorder, and the prevalence rate of anxiety disorders among youths with chronic medical illnesses is higher compared to their healthy counterparts. Anxiety disorders may develop secondary to predisposing biological mechanisms related to a child's specific medical illness, as a response to being ill or in the hospital, a threatening environment, as a result of other genetic and psychological factors, or as a combination of all these factors. Additionally, exposure to physical pain early in one's life and/or frequent painful medical procedures are correlated with fear and anxiety during subsequent procedures and treatments, and may lead to medical nonadherence and other comorbidities. Anxiety disorders can have serious consequences in children/adolescents with chronic and/or life-limiting medical illnesses. Therefore, proper identification and treatment of anxiety disorders is necessary and may improve not only psychiatric symptoms but also physical symptoms. Behavioral and cognitive methods as well as psychotropic medications are used to treat anxiety disorders in pediatric patients. We will review current treatments for anxiety in children/adolescents with medical illnesses and propose future research directions. Depression and Anxiety, 2011. ? 2010 Wiley-Liss, Inc. JF - Depression and Anxiety (Hoboken) AU - Pao, Maryland AU - Bosk, Abigail Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 40 EP - 49 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 28 IS - 1 SN - 1520-6394, 1520-6394 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Adolescence KW - Adolescents KW - Anxiety KW - Children KW - Cognitive ability KW - Depression KW - Fear KW - Hospitals KW - Morbidity KW - Pain KW - Pediatrics KW - Psychology KW - Reviews KW - Risk factors KW - depression KW - pain KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017969138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Depression+and+Anxiety+%28Hoboken%29&rft.atitle=Anxiety+in+medically+ill+children%2Fadolescents&rft.au=Pao%2C+Maryland%3BBosk%2C+Abigail&rft.aulast=Pao&rft.aufirst=Maryland&rft.date=2011-01-01&rft.volume=28&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Depression+and+Anxiety+%28Hoboken%29&rft.issn=15206394&rft_id=info:doi/10.1002%2Fda.20727 L2 - http://onlinelibrary.wiley.com/doi/10.1002/da.20727/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Depression; Anxiety; Fear; Pediatrics; Cognitive ability; Risk factors; Adolescence; Pain; Children; Hospitals; Psychology; Reviews; pain; depression; Morbidity; Adolescents DO - http://dx.doi.org/10.1002/da.20727 ER - TY - JOUR T1 - MMTV-Cre transgenes can adversely affect lactation: Considerations for conditional gene deletion in mammary tissue AN - 1017965741; 14602997 AB - CRE-loxP-mediated inactivation and activation of genes in mouse mammary epithelium have been widely used to study genetic pathways in normal development and neoplastic transformation in vivo. In 1997, we generated three distinct mouse lines carrying an identical MMTV-Cre transgene (lines A, D, and F). Because the presence of CRE recombinase can adversely affect the physiology of nonmammary cells, we explored whether transgenic females display lactational defects. Whereas dams from line D nurse their pups and display overtly normal mammary development, line A shows some impairment during lactation and females from line F completely fail to nurse their litters. The ability to nurse a litter correlates with the extent of alveolar development and differentiation. This study demonstrates the importance of including appropriate "Cre-only" controls and provides guidelines to avoid problems in data interpretation. JF - Analytical Biochemistry AU - Robinson, Gertraud W AU - Hennighausen, Lothar AD - Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA, traudl@nih.gov PY - 2011 SP - 92 EP - 95 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 412 IS - 1 SN - 0003-2697, 0003-2697 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Mouse mammary tumor virus KW - Long terminal repeat KW - CRE recombinase KW - Mammary gland KW - Lactation KW - Transgenic mice KW - Transformation KW - Litter KW - Data processing KW - Transgenes KW - Alveoli KW - Differentiation KW - Gene deletion KW - Dams KW - Cre recombinase KW - Epithelium KW - Transcription activation KW - W 30925:Genetic Engineering KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017965741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=MMTV-Cre+transgenes+can+adversely+affect+lactation%3A+Considerations+for+conditional+gene+deletion+in+mammary+tissue&rft.au=Robinson%2C+Gertraud+W%3BHennighausen%2C+Lothar&rft.aulast=Robinson&rft.aufirst=Gertraud&rft.date=2011-01-01&rft.volume=412&rft.issue=1&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/10.1016%2Fj.ab.2011.01.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-01-06 N1 - SubjectsTermNotLitGenreText - Transformation; Differentiation; Gene deletion; Litter; Data processing; Dams; Transgenes; Cre recombinase; Epithelium; Alveoli; Transcription activation; Lactation DO - http://dx.doi.org/10.1016/j.ab.2011.01.020 ER - TY - JOUR T1 - Effects of Metformin on Body Weight and Body Composition in Obese Insulin-Resistant Children: A Randomized Clinical Trial AN - 1011211775; 14299904 AB - OBJECTIVE: Metformin can decrease adiposity and ameliorate obesity-related comorbid conditions, including abnormalities in glucose homeostasis in adolescents, but there are few data evaluating the efficacy of metformin among younger children. Our objective was to determine whether metformin treatment causes weight loss and improves obesity-related comorbidities in obese children, who are insulin-resistant. RESEARCH DESIGN AND METHODS: This study was a randomized double-blind placebo-controlled trial consisting of 100 severely obese (mean BMI 34.6 plus or minus 6.6 kg/m2) insulin-resistant children aged 6-12 years, randomized to 1,000 mg metformin (n = 53) or placebo (n = 47) twice daily for 6 months, followed by open-label metformin treatment for 6 months. All children and their parents participated in a monthly dietitian-administered weight-reduction program. RESULTS: Eighty-five percent completed the 6-month randomized phase. Children prescribed metformin had significantly greater decreases in BMI (difference -1.09 kg/m2, CI -1.87 to -0.31, P = 0.006), body weight (difference -3.38 kg, CI -5.2 to -1.57, P < 0.001), BMI Z score (difference between metformin and placebo groups -0.07, CI -0.12 to -0.01, P = 0.02), and fat mass (difference -1.40 kg, CI -2.74 to -0.06, P = 0.04). Fasting plasma glucose (P = 0.007) and homeostasis model assessment (HOMA) insulin resistance index (P = 0.006) also improved more in metformin-treated children than in placebo-treated children. Gastrointestinal symptoms were significantly more prevalent in metformin-treated children, which limited maximal tolerated dosage in 17%. During the 6-month open-label phase, children treated previously with placebo decreased their BMI Z score; those treated continuously with metformin did not significantly change BMI Z score further. CONCLUSIONS: Metformin had modest but favorable effects on body weight, body composition, and glucose homeostasis in obese insulin-resistant children participating in a low-intensity weight-reduction program. JF - Diabetes AU - Yanovski, Jack A AU - Krakoff, Jonathan AU - Salaita, Christine G AU - McDuffie, Jennifer R AU - Kozlosky, Merel AU - Sebring, Nancy G AU - Reynolds, James C AU - Brady, Sheila M AU - Calis, Karim A AD - Unit on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 477 EP - 485 PB - American Diabetes Association, 1701 N. Beauregard St. Alexandria VA 22311 USA VL - 60 IS - 2 SN - 0012-1797, 0012-1797 KW - Physical Education Index KW - Obesity KW - Programs KW - Body mass KW - Adolescence KW - Diet (weight control) KW - Blood glucose KW - Children KW - Body composition KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011211775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes&rft.atitle=Effects+of+Metformin+on+Body+Weight+and+Body+Composition+in+Obese+Insulin-Resistant+Children%3A+A+Randomized+Clinical+Trial&rft.au=Yanovski%2C+Jack+A%3BKrakoff%2C+Jonathan%3BSalaita%2C+Christine+G%3BMcDuffie%2C+Jennifer+R%3BKozlosky%2C+Merel%3BSebring%2C+Nancy+G%3BReynolds%2C+James+C%3BBrady%2C+Sheila+M%3BCalis%2C+Karim+A&rft.aulast=Yanovski&rft.aufirst=Jack&rft.date=2011-01-01&rft.volume=60&rft.issue=2&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Diabetes&rft.issn=00121797&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-05-07 N1 - SubjectsTermNotLitGenreText - Obesity; Programs; Adolescence; Body mass; Diet (weight control); Blood glucose; Body composition; Children ER - TY - JOUR T1 - Core body temperature in obesity AN - 1011203304; 14699350 AB - BACKGROUND: A lower core body temperature set point has been suggested to be a factor that could potentially predispose humans to develop obesity. OBJECTIVE: We tested the hypothesis that obese individuals have lower core temperatures than those in normal-weight individuals. DESIGN: In study 1, nonobese [body mass index (BMI; in kg/m2) <30] and obese (BMI greater than or equal to 30) adults swallowed wireless core temperature-sensing capsules, and we measured core temperatures continuously for 24 h. In study 2, normal-weight (BMI of 18-25) and obese subjects swallowed temperature-sensing capsules to measure core temperatures continuously for greater than or equal to 48 h and kept activity logs. We constructed daily, 24-h core temperature profiles for analysis. RESULTS: Mean ( plus or minus SE) daily core body temperature did not differ significantly between the 35 nonobese and 46 obese subjects (36.92 plus or minus 0.03 degree C compared with 36.89 plus or minus 0.03 degree C; P = 0.44). Core temperature 24-h profiles did not differ significantly between 11 normal-weight and 19 obese subjects (P = 0.274). Women had a mean core body temperature approximately 0.23 degree C greater than that of men (36.99 plus or minus 0.03 degree C compared with 36.76 plus or minus 0.03 degree C; P < 0.0001). CONCLUSIONS: Obesity is not generally associated with a reduced core body temperature. It may be necessary to study individuals with function-altering mutations in core temperature-regulating genes to determine whether differences in the core body temperature set point affect the regulation of human body weight. These trials were registered at clinicaltrials.gov as NCT00428987 and NCT00266500. JF - American Journal of Clinical Nutrition AU - Heikens, Marc J AU - Gorbach, Alexander M AU - Eden, Henry S AU - Savastano, David M AU - Chen, Kong Y AU - Skarulis, Monica C AU - Yanovski, Jack A AD - From the Unit on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MJH, DMS, and JAY), the Biomedical Engineering and Physical Science Shared Resource, National Institute of Biomedical Imaging and Bioengineering (AMG and HSE), and the Clinical Endocrinology Branch, National Institute of Diabetes, Digestive, and Kidney Diseases (KYC and MCS), National Institutes of Health, US Department of Health and Human Services, Bethesda, MD Y1 - 2011 PY - 2011 DA - 2011 SP - 963 EP - 967 PB - American Society for Clinical Nutrition, 3247 Meyer Hall, University of California Davis CA 95616-8790 USA VL - 93 IS - 5 SN - 0002-9165, 0002-9165 KW - Physical Education Index KW - Adults KW - Analysis KW - Body mass KW - Body temperature KW - Measurement KW - Nutrition KW - Obesity KW - Weight KW - Women KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011203304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Clinical+Nutrition&rft.atitle=Core+body+temperature+in+obesity&rft.au=Heikens%2C+Marc+J%3BGorbach%2C+Alexander+M%3BEden%2C+Henry+S%3BSavastano%2C+David+M%3BChen%2C+Kong+Y%3BSkarulis%2C+Monica+C%3BYanovski%2C+Jack+A&rft.aulast=Heikens&rft.aufirst=Marc&rft.date=2011-01-01&rft.volume=93&rft.issue=5&rft.spage=963&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Clinical+Nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Measurement; Obesity; Weight; Body temperature; Analysis; Body mass; Women; Adults; Nutrition ER - TY - JOUR T1 - Issues in the Assessment of "Race" Among Latinos: Implications for Research and Policy AN - 1010630682; 201210459 AB - Measurement of race and ethnicity is integral to assessing and addressing health disparities experienced by minorities. However, the unique experiences of Latinos related to race and the discordance between understandings of race among Latinos and the predominant U.S. conceptualizations of this construct impact how Latinos respond to measurement approaches. As a result, data collection methodologies often yield ambiguous responses that reveal little about this population. This article examines Latinos' racial responding, and how this relates to their experiences and understanding of their racial identity. We recommend the use of a combined race and ethnicity question and open-ended race and ethnicity questions, when feasible, which will likely yield more meaningful data that can be used to address this populations' health needs. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Hispanic Journal of Behavioral Sciences AU - Allen, Vincent C AU - Lachance, Christina AU - Rios-Ellis, Britt AU - Kaphingst, Kimberly A AD - National Human Genome Research Institute, Montgomery Village, MD, USA Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 411 EP - 424 PB - Sage Publications, Thousand Oaks CA VL - 33 IS - 4 SN - 0739-9863, 0739-9863 KW - racial identity racial measurement health disparities Latino KW - Methodology (Data Collection) KW - Minority Groups KW - Hispanic Americans KW - Ethnic Groups KW - Ethnicity KW - Race KW - Health KW - Ethnic Identity KW - article KW - 0410: group interactions; social group identity & intergroup relations (groups based on race & ethnicity, age, & sexual orientation) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010630682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hispanic+Journal+of+Behavioral+Sciences&rft.atitle=Issues+in+the+Assessment+of+%22Race%22+Among+Latinos%3A+Implications+for+Research+and+Policy&rft.au=Allen%2C+Vincent+C%3BLachance%2C+Christina%3BRios-Ellis%2C+Britt%3BKaphingst%2C+Kimberly+A&rft.aulast=Allen&rft.aufirst=Vincent&rft.date=2011-01-01&rft.volume=33&rft.issue=4&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=Hispanic+Journal+of+Behavioral+Sciences&rft.issn=07399863&rft_id=info:doi/10.1177%2F0739986311422880 LA - English DB - Sociological Abstracts N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - HJBSEZ N1 - SubjectsTermNotLitGenreText - Race; Hispanic Americans; Ethnicity; Health; Minority Groups; Methodology (Data Collection); Ethnic Groups; Ethnic Identity DO - http://dx.doi.org/10.1177/0739986311422880 ER - TY - JOUR T1 - Transgenic Mice with -6A Haplotype of the Human Angiotensinogen Gene Have Increased Blood Pressure Compared with -6G Haplotype AN - 860383477; 14154687 AB - Hypertension is a serious risk factor for cardiovascular disease, and the angiotensinogen (AGT) gene locus is associated with human essential hypertension. The human AGT (hAGT) gene has an A/G polymorphism at -6, and the -6A allele is associated with increased blood pressure. However, transgenic mice containing 1.2 kb of the promoter with -6A of the hAGT gene show neither increased plasma AGT level nor increased blood pressure compared with -6G. We have found that the hAGT gene has three additional SNPs (A/G at -1670, C/G at -1562, and T/G at -1561). Variants -1670A, -1562C, and -1561T almost always occur with -6A, and variants -1670G, -1562G, and -1561G almost always occur with -6G. Therefore, the hAGT gene may be subdivided into either -6A or -6G haplotypes. We show that these polymorphisms affect the binding of HNF-1 alpha and glucocorticoid receptor to the promoter, and a reporter construct containing a 1.8-kb hAGT gene promoter with -6A haplotype has 4-fold increased glucocorticoid-induced promoter activity as compared with -6G haplotype. In order to understand the physiological significance of these haplotypes in an in vivo situation, we have generated double transgenic mice containing either the -6A or -6G haplotype of the hAGT gene and the human renin gene. Our ChIP assay shows that HNF-1 alpha and glucocorticoid receptor have stronger affinity for the chromatin obtained from the liver of transgenic mice containing -6A haplotype. Our studies also show that transgenic mice containing -6A haplotype have increased plasma AGT level and increased blood pressure as compared with -6G haplotype. Our studies explain the molecular mechanism involved in association of the -6A allele of the hAGT gene with hypertension. JF - Journal of Biological Chemistry AU - Jain, Sudhir AU - Tillinger, Andrej AU - Mopidevi, Brahmaraju AU - Pandey, Varunkumar G AU - Chauhan, Chetankumar K AU - Fiering, Steven N AU - Warming, Soren AU - Kumar, Ashok AD - From the Department of Pathology, New York Medical College, Valhalla, New York 10595, the Department of Microbiology, Immunology and Genetics, Dartmouth Medical School, Dartmouth, New Hampshire 03755, and the Mouse Cancer Genetics Program, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702 Y1 - 2010/12/24/ PY - 2010 DA - 2010 Dec 24 SP - 41172 EP - 41186 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 285 IS - 52 SN - 0021-9258, 0021-9258 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Renin KW - angiotensinogen KW - Molecular modelling KW - AGT gene KW - Chromatin KW - Gene polymorphism KW - Transgenic mice KW - Blood pressure KW - Promoters KW - Glucocorticoid receptors KW - Haplotypes KW - Single-nucleotide polymorphism KW - Risk factors KW - Liver KW - Cardiovascular diseases KW - Hypertension KW - W 30925:Genetic Engineering KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860383477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Transgenic+Mice+with+-6A+Haplotype+of+the+Human+Angiotensinogen+Gene+Have+Increased+Blood+Pressure+Compared+with+-6G+Haplotype&rft.au=Jain%2C+Sudhir%3BTillinger%2C+Andrej%3BMopidevi%2C+Brahmaraju%3BPandey%2C+Varunkumar+G%3BChauhan%2C+Chetankumar+K%3BFiering%2C+Steven+N%3BWarming%2C+Soren%3BKumar%2C+Ashok&rft.aulast=Jain&rft.aufirst=Sudhir&rft.date=2010-12-24&rft.volume=285&rft.issue=52&rft.spage=41172&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - angiotensinogen; Renin; Molecular modelling; AGT gene; Chromatin; Gene polymorphism; Transgenic mice; Blood pressure; Promoters; Haplotypes; Glucocorticoid receptors; Single-nucleotide polymorphism; Risk factors; Liver; Cardiovascular diseases; Hypertension ER - TY - JOUR T1 - Substrate channeling in mammalian base excision repair pathways: passing the baton. AN - 820789390; 20952393 AB - The current model for base excision repair (BER) involves two general sub-pathways termed single-nucleotide BER and long patch BER that are distinguished by their repair patch sizes and the enzymes/co-factors involved. Both sub-pathways involve a series of sequential steps from initiation to completion of repair. The BER sub-pathways are designed to sequester the various intermediates, passing them along from one step to the next without allowing these toxic molecules to trigger cell cycle arrest, necrotic cell death, or apoptosis. Although a variety of DNA-protein and protein-protein interactions are known for the BER intermediates and enzymes/co-factors, the molecular mechanisms accounting for step-to-step coordination are not well understood. In the present study we designed an in vitro assay to explore the question of whether there is a channeling or "hand-off" of the repair intermediates during BER in vitro. The results show that when BER enzymes are pre-bound to the initial single-nucleotide BER intermediate, the DNA is channeled from apurinic/apyrimidinic endonuclease 1 to DNA polymerase β and then to DNA ligase. In the long patch BER subpathway, where the 5'-end of the incised strand is blocked, the intermediate after DNA polymerase β gap filling is not channeled to the subsequent enzyme, flap endonuclease 1. Instead, flap endonuclease 1 must recognize and bind to the intermediate in competition with other molecules. JF - The Journal of biological chemistry AU - Prasad, Rajendra AU - Shock, David D AU - Beard, William A AU - Wilson, Samuel H AD - Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2010/12/24/ PY - 2010 DA - 2010 Dec 24 SP - 40479 EP - 40488 VL - 285 IS - 52 KW - DNA-Binding Proteins KW - 0 KW - DNA KW - 9007-49-2 KW - DNA Polymerase beta KW - EC 2.7.7.- KW - Flap Endonucleases KW - EC 3.1.- KW - FEN1 protein, human KW - EC 3.1.11.- KW - DNA-(Apurinic or Apyrimidinic Site) Lyase KW - EC 4.2.99.18 KW - Index Medicus KW - Animals KW - Necrosis KW - Humans KW - Apoptosis -- physiology KW - DNA-Binding Proteins -- genetics KW - DNA-Binding Proteins -- metabolism KW - DNA Repair -- physiology KW - DNA-(Apurinic or Apyrimidinic Site) Lyase -- genetics KW - DNA-(Apurinic or Apyrimidinic Site) Lyase -- metabolism KW - DNA Polymerase beta -- genetics KW - DNA -- metabolism KW - DNA -- genetics KW - Flap Endonucleases -- genetics KW - Flap Endonucleases -- metabolism KW - Models, Biological KW - DNA Polymerase beta -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/820789390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Substrate+channeling+in+mammalian+base+excision+repair+pathways%3A+passing+the+baton.&rft.au=Prasad%2C+Rajendra%3BShock%2C+David+D%3BBeard%2C+William+A%3BWilson%2C+Samuel+H&rft.aulast=Prasad&rft.aufirst=Rajendra&rft.date=2010-12-24&rft.volume=285&rft.issue=52&rft.spage=40479&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M110.155267 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-24 N1 - Date created - 2010-12-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Proteomics. 2008 Nov;7(11):2279-87 [18622019] Methods Enzymol. 2006;409:39-52 [16793394] Science. 1999 Dec 3;286(5446):1897-905 [10583946] J Biol Chem. 2000 Feb 11;275(6):4460-6 [10660619] Nature. 2000 Jan 27;403(6768):451-6 [10667800] Nat Struct Biol. 2000 Mar;7(3):176-8 [10700268] Prog Nucleic Acid Res Mol Biol. 2001;68:151-64 [11554294] J Biol Chem. 2004 Jun 11;279(24):25268-75 [15078879] Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13738-43 [15365186] Annu Rev Biochem. 1982;51:61-87 [6287922] Biochemistry. 1986 Apr 22;25(8):2212-20 [2423122] Annu Rev Genet. 1986;20:201-30 [3545059] J Biol Chem. 1990 Feb 5;265(4):2124-31 [2404980] Mutat Res. 1990 Sep-Nov;236(2-3):173-201 [1697933] Biochemistry. 1990 Aug 7;29(31):7156-9 [2207097] J Biol Chem. 1991 Oct 15;266(29):19618-25 [1918069] Mol Cell Biol. 1992 Apr;12(4):1605-12 [1549115] Nature. 1993 Apr 22;362(6422):709-15 [8469282] Mol Cell Biol. 1994 Jan;14(1):310-7 [8264597] Mol Cell Biol. 1994 Jan;14(1):68-76 [8264637] Prog Nucleic Acid Res Mol Biol. 1994;48:315-70 [7938553] J Biol Chem. 1994 Dec 16;269(50):31923-8 [7989368] Biochemistry. 1995 Jan 10;34(1):128-38 [7819187] J Biol Chem. 1995 Jan 13;270(2):949-57 [7822335] Curr Biol. 1994 Dec 1;4(12):1069-76 [7535646] Science. 1995 Aug 4;269(5224):699-702 [7624801] Methods Enzymol. 1995;262:98-107 [8594388] Nature. 1996 Jan 11;379(6561):183-6 [8538772] J Biol Chem. 1996 Apr 19;271(16):9573-8 [8621631] J Biol Chem. 1996 Jul 5;271(27):16000-7 [8663274] J Biol Chem. 1996 Jul 26;271(30):17811-5 [8663612] EMBO J. 1996 Dec 2;15(23):6662-70 [8978692] J Biol Chem. 1997 Jan 10;272(2):1302-7 [8995436] EMBO J. 1997 Jun 2;16(11):3341-8 [9214649] Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12754-7 [9398071] J Biol Chem. 1998 Jan 9;273(2):898-902 [9422747] Biochemistry. 1998 Mar 17;37(11):3575-80 [9530283] J Biol Chem. 1998 Jun 12;273(24):15263-70 [9614142] Mutat Res. 1998 Jun;407(3):203-15 [9653447] J Biol Chem. 1998 Aug 14;273(33):21203-9 [9694877] Curr Opin Struct Biol. 1999 Feb;9(1):37-47 [10047578] J Biol Chem. 2005 Feb 4;280(5):3665-74 [15561706] DNA Repair (Amst). 2005 Dec 8;4(12):1347-57 [16172026] DNA Repair (Amst). 2010 Feb 4;9(2):109-19 [20006562] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M110.155267 ER - TY - JOUR T1 - Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. AN - 820793626; 21172655 AB - Genetic deletion of the mitochondrial deacetylase sirtuin-3 (Sirt3) results in increased mitochondrial superoxide, a tumor-permissive environment, and mammary tumor development. MnSOD contains a nutrient- and ionizing radiation (IR)-dependent reversible acetyl-lysine that is hyperacetylated in Sirt3⁻/⁻ livers at 3 months of age. Livers of Sirt3⁻/⁻ mice exhibit decreased MnSOD activity, but not immunoreactive protein, relative to wild-type livers. Reintroduction of wild-type but not deacetylation null Sirt3 into Sirt3⁻/⁻ MEFs deacetylated lysine and restored MnSOD activity. Site-directed mutagenesis of MnSOD lysine 122 to an arginine, mimicking deacetylation (lenti-MnSOD(K122-R)), increased MnSOD activity when expressed in MnSOD⁻/⁻ MEFs, suggesting acetylation directly regulates function. Furthermore, infection of Sirt3⁻/⁻ MEFs with lenti-MnSOD(K122-R) inhibited in vitro immortalization by an oncogene (Ras), inhibited IR-induced genomic instability, and decreased mitochondrial superoxide. Finally, IR was unable to induce MnSOD deacetylation or activity in Sirt3⁻/⁻ livers, and these irradiated livers displayed significant IR-induced cell damage and microvacuolization in their hepatocytes. Copyright © 2010 Elsevier Inc. All rights reserved. JF - Molecular cell AU - Tao, Randa AU - Coleman, Mitchell C AU - Pennington, J Daniel AU - Ozden, Ozkan AU - Park, Seong-Hoon AU - Jiang, Haiyan AU - Kim, Hyun-Seok AU - Flynn, Charles Robb AU - Hill, Salisha AU - Hayes McDonald, W AU - Olivier, Alicia K AU - Spitz, Douglas R AU - Gius, David AD - Howard Hughes Medical Institute and Molecular Radiation Oncology, Radiation Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA. Y1 - 2010/12/22/ PY - 2010 DA - 2010 Dec 22 SP - 893 EP - 904 VL - 40 IS - 6 KW - Sirt3 protein, mouse KW - 0 KW - Arginine KW - 94ZLA3W45F KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Sirtuin 3 KW - EC 3.5.1.- KW - Lysine KW - K3Z4F929H6 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Animals KW - Acetylation KW - Arginine -- metabolism KW - Mice KW - Cell Line KW - Conserved Sequence KW - Oxidative Stress KW - Superoxide Dismutase -- metabolism KW - Sirtuin 3 -- metabolism KW - Sirtuin 3 -- genetics KW - Lysine -- metabolism KW - Evolution, Molecular KW - Sirtuin 3 -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/820793626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cell&rft.atitle=Sirt3-mediated+deacetylation+of+evolutionarily+conserved+lysine+122+regulates+MnSOD+activity+in+response+to+stress.&rft.au=Tao%2C+Randa%3BColeman%2C+Mitchell+C%3BPennington%2C+J+Daniel%3BOzden%2C+Ozkan%3BPark%2C+Seong-Hoon%3BJiang%2C+Haiyan%3BKim%2C+Hyun-Seok%3BFlynn%2C+Charles+Robb%3BHill%2C+Salisha%3BHayes+McDonald%2C+W%3BOlivier%2C+Alicia+K%3BSpitz%2C+Douglas+R%3BGius%2C+David&rft.aulast=Tao&rft.aufirst=Randa&rft.date=2010-12-22&rft.volume=40&rft.issue=6&rft.spage=893&rft.isbn=&rft.btitle=&rft.title=Molecular+cell&rft.issn=1097-4164&rft_id=info:doi/10.1016%2Fj.molcel.2010.12.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-26 N1 - Date created - 2010-12-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biomed Pharmacother. 2005 May;59(4):143-8 [15862707] J Biol Chem. 2004 Dec 3;279(49):50754-63 [15381699] Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10224-9 [16788062] Cold Spring Harb Symp Quant Biol. 2005;70:363-74 [16869773] Cancer Res. 2006 Aug 1;66(15):7615-20 [16885361] Mol Cell. 2007 Oct 12;28(1):91-106 [17936707] Mol Cell Biol. 2007 Dec;27(24):8807-14 [17923681] Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14447-52 [18794531] Biochem J. 2009 Feb 15;418(1):29-37 [18937644] Nature. 2009 Jul 30;460(7255):587-91 [19641587] Cancer Biol Ther. 2009 Oct;8(20):1962-71 [19738419] Cancer Cell. 2010 Jan 19;17(1):41-52 [20129246] J Cell Biol. 2002 Aug 19;158(4):647-57 [12186850] Cancer Cell. 2002 Aug;2(2):103-12 [12204530] Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13653-8 [12374852] Anal Biochem. 1989 May 15;179(1):8-18 [2547324] Ann N Y Acad Sci. 2006 May;1067:182-90 [16803984] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.molcel.2010.12.013 ER - TY - JOUR T1 - Chronic forced exercise during adolescence decreases cocaine conditioned place preference in Lewis rats AN - 817601580; 13530561 AB - a[cent Chronic forced exercise during adolescence blocks the formation of cocaine CPP in males during young adulthood. a[cent Chronic forced exercise in adolescence decreases cocaine CPP, but does not eliminate its formation altogether, in young adult females. a[cent There is a gender difference in cocaine CPP, such that female rats exhibit greater preference than males. Chronic physical activity (exercise) may be beneficial in the prevention of substance use disorders; however, the extent to which physical activity can interfere with the reinforcing effects of drugs during the adolescent period, which is one of great vulnerability for drug experimentation, has not been fully evaluated. Here, we assess the effects of chronic forced exercise during adolescence on preference for cocaine using the conditioned place preference (CPP) paradigm in male and female Lewis rats. The group of rats exposed to exercise ran on a treadmill for 6 weeks on a progressive time-increased schedule for up to 1h of exercise per day, while the groups of sedentary rats remained in their home cage. Following the 6 weeks of exercise exposure, rats were tested for cocaine CPP. Results showed that chronic exercise significantly attenuated cocaine CPP in both males and females compared to a sedentary environment. Furthermore, male exercise rats failed to show significant cocaine CPP. In contrast, female exercise rats still showed cocaine CPP but it was significantly reduced compared to the female sedentary rats. Females also exhibited greater cocaine CPP than males overall. These findings suggest that strategies to promote physical activity during adolescence may be protective against cocaine abuse in both males and females, and these findings merit further investigation. We also corroborate a gender-specific sensitivity to the reinforcing effects of cocaine, highlighting the need to consider gender-tailored exercise interventions for drug abuse prevention. JF - Behavioural Brain Research AU - Thanos, Panayotis K AU - Tucci, Andrew AU - Stamos, Joshua AU - Robison, Lisa AU - Wang, Gene-Jack AU - Anderson, Brenda J AU - Volkow, Nora D AD - Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, United States Y1 - 2010/12/20/ PY - 2010 DA - 2010 Dec 20 SP - 77 EP - 82 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 215 IS - 1 SN - 0166-4328, 0166-4328 KW - Toxicology Abstracts; Animal Behavior Abstracts; CSA Neurosciences Abstracts KW - Adolescence KW - Cocaine KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25070:Learning, Memory, Reinforcement, and Motivation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/817601580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+Brain+Research&rft.atitle=Chronic+forced+exercise+during+adolescence+decreases+cocaine+conditioned+place+preference+in+Lewis+rats&rft.au=Thanos%2C+Panayotis+K%3BTucci%2C+Andrew%3BStamos%2C+Joshua%3BRobison%2C+Lisa%3BWang%2C+Gene-Jack%3BAnderson%2C+Brenda+J%3BVolkow%2C+Nora+D&rft.aulast=Thanos&rft.aufirst=Panayotis&rft.date=2010-12-20&rft.volume=215&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Behavioural+Brain+Research&rft.issn=01664328&rft_id=info:doi/10.1016%2Fj.bbr.2010.06.033 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Cocaine DO - http://dx.doi.org/10.1016/j.bbr.2010.06.033 ER - TY - JOUR T1 - The prostaglandin E2 receptor, EP2, stimulates keratinocyte proliferation in mouse skin by G protein-dependent and {beta}-arrestin1-dependent signaling pathways. AN - 821191083; 20959465 AB - The prostaglandin E(2) (PGE(2)) G protein-coupled receptor (GPCR), EP2, plays important roles in mouse skin tumor development (Chun, K. S., Lao, H. C., Trempus, C. S., Okada, M., and Langenbach, R. (2009) Carcinogenesis 30, 1620-1627). Because keratinocyte proliferation is essential for skin tumor development, EP2-mediated signaling pathways that contribute to keratinocyte proliferation were investigated. A single topical application of the EP2 agonist, butaprost, dose-dependently increased keratinocyte replication via activation of epidermal growth factor receptor (EGFR) and PKA signaling. Because GPCR-mediated activation of EGFR can involve the formation of a GPCR-β-arrestin-Src signaling complex, the possibility of a β-arrestin1-Src complex contributing to EP2-mediated signaling in keratinocytes was investigated. Butaprost induced β-arrestin1-Src complex formation and increased both Src and EGFR activation. A role for β-arrestin1 in EP2-mediated Src and EGFR activation was demonstrated by the observation that β-arrestin1 deficiency significantly reduced Src and EGFR activation. In agreement with a β-arrestin1-Src complex contributing to EGFR activation, Src and EGFR inhibition (PP2 and AG1478, respectively) indicated that Src was upstream of EGFR. Butaprost also induced the activation of Akt, ERK1/2, and STAT3, and both β-arrestin1 deficiency and EGFR inhibition (AG1478 or gefitinib) decreased their activation. In addition to β-arrestin1-dependent EGFR activation, butaprost increased PKA activation, as measured by phospho-GSK3β (p-GSK3β) and p-cAMP-response element-binding protein formation. PKA inhibition (H89 or R(P)-adenosine-3',5'-cyclic monophosphorothioate (R(P)-cAMPS)) decreased butaprost-induced cAMP-response element-binding protein and ERK activation but did not affect EGFR activation, whereas β-arrestin1 deficiency decreased EGFR activation but did not affect butaprost-induced PKA activation, thus indicating that they were independent EP2-mediated pathways. Therefore, the results indicate that EP2 contributed to mouse keratinocyte proliferation by G protein-independent, β-arrestin1-dependent activation of EGFR and G protein-dependent activation of PKA. JF - The Journal of biological chemistry AU - Chun, Kyung-Soo AU - Lao, Huei-Chen AU - Langenbach, Robert AD - Laboratory of Toxicology and Pharmacology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2010/12/17/ PY - 2010 DA - 2010 Dec 17 SP - 39672 EP - 39681 VL - 285 IS - 51 KW - Arrestins KW - 0 KW - Multiprotein Complexes KW - Protein Kinase Inhibitors KW - Quinazolines KW - Receptors, Prostaglandin E, EP2 Subtype KW - STAT3 Transcription Factor KW - Stat3 protein, mouse KW - Tyrphostins KW - beta-Arrestins KW - tyrphostin AG 1478 KW - 170449-18-0 KW - EGFR protein, mouse KW - EC 2.7.10.1 KW - Receptor, Epidermal Growth Factor KW - src-Family Kinases KW - EC 2.7.10.2 KW - Glycogen Synthase Kinase 3 beta KW - EC 2.7.11.1 KW - Gsk3b protein, mouse KW - Proto-Oncogene Proteins c-akt KW - Cyclic AMP-Dependent Protein Kinases KW - EC 2.7.11.11 KW - Mitogen-Activated Protein Kinase 3 KW - EC 2.7.11.24 KW - Glycogen Synthase Kinase 3 KW - EC 2.7.11.26 KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Alprostadil KW - F5TD010360 KW - butaprost KW - HP16WVP23Y KW - gefitinib KW - S65743JHBS KW - Index Medicus KW - Cyclic AMP-Dependent Protein Kinases -- metabolism KW - Proto-Oncogene Proteins c-akt -- genetics KW - Animals KW - Mitogen-Activated Protein Kinase 3 -- genetics KW - src-Family Kinases -- genetics KW - src-Family Kinases -- metabolism KW - Enzyme Activation -- drug effects KW - Cyclic AMP-Dependent Protein Kinases -- antagonists & inhibitors KW - Tyrphostins -- pharmacology KW - Alprostadil -- pharmacology KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Receptor, Epidermal Growth Factor -- metabolism KW - Multiprotein Complexes -- genetics KW - Protein Kinase Inhibitors -- pharmacology KW - Dose-Response Relationship, Drug KW - Mice KW - Cyclic AMP-Dependent Protein Kinases -- genetics KW - src-Family Kinases -- antagonists & inhibitors KW - Enzyme Activation -- genetics KW - Mitogen-Activated Protein Kinase 3 -- metabolism KW - Receptor, Epidermal Growth Factor -- genetics KW - Glycogen Synthase Kinase 3 -- genetics KW - Alprostadil -- analogs & derivatives KW - Mitogen-Activated Protein Kinase 3 -- antagonists & inhibitors KW - STAT3 Transcription Factor -- genetics KW - Glycogen Synthase Kinase 3 -- metabolism KW - STAT3 Transcription Factor -- metabolism KW - Proto-Oncogene Proteins c-akt -- antagonists & inhibitors KW - Quinazolines -- pharmacology KW - Multiprotein Complexes -- metabolism KW - Signal Transduction -- physiology KW - Arrestins -- genetics KW - Receptors, Prostaglandin E, EP2 Subtype -- metabolism KW - Skin -- metabolism KW - GTP-Binding Proteins -- metabolism KW - Signal Transduction -- drug effects KW - Keratinocytes -- cytology KW - Keratinocytes -- metabolism KW - Cell Proliferation KW - GTP-Binding Proteins -- genetics KW - Arrestins -- metabolism KW - Receptors, Prostaglandin E, EP2 Subtype -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821191083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=The+prostaglandin+E2+receptor%2C+EP2%2C+stimulates+keratinocyte+proliferation+in+mouse+skin+by+G+protein-dependent+and+%7Bbeta%7D-arrestin1-dependent+signaling+pathways.&rft.au=Chun%2C+Kyung-Soo%3BLao%2C+Huei-Chen%3BLangenbach%2C+Robert&rft.aulast=Chun&rft.aufirst=Kyung-Soo&rft.date=2010-12-17&rft.volume=285&rft.issue=51&rft.spage=39672&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M110.117689 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-11 N1 - Date created - 2010-12-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: FASEB J. 1990 Aug;4(11):2881-9 [2165947] J Clin Invest. 1986 Jan;77(1):246-51 [3080474] Circ Res. 1997 Dec;81(6):1021-6 [9400383] Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1415-20 [9990038] Curr Opin Cell Biol. 1999 Apr;11(2):177-83 [10209148] Science. 2005 Apr 22;308(5721):512-7 [15845844] Cancer Res. 2005 May 1;65(9):3958-65 [15867397] Cancer Res. 2005 Jun 1;65(11):4496-9 [15930264] Prostaglandins Other Lipid Mediat. 2005 May;76(1-4):48-58 [15967161] Cancer Res. 2005 Oct 15;65(20):9304-11 [16230392] Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1492-7 [16432186] Gene. 2006 Jan 17;366(1):2-16 [16377102] Cancer Res. 2006 Mar 1;66(5):2700-7 [16510590] Oncogene. 2006 Sep 7;25(40):5507-16 [16607275] Cancer Cell. 2006 Oct;10(4):269-80 [17045205] Cancer Res. 2007 Mar 1;67(5):2015-21 [17332329] Cancer Res. 2004 Apr 1;64(7):2382-9 [15059889] Mol Carcinog. 2007 Aug;46(8):725-31 [17610223] FASEB J. 2007 Aug;21(10):2418-30 [17384145] J Clin Invest. 2007 Sep;117(9):2445-58 [17786238] Carcinogenesis. 2007 Oct;28(10):2063-8 [17277233] Cancer Res. 2007 Nov 15;67(22):10879-88 [18006833] J Cell Physiol. 2008 Feb;214(2):371-80 [17654493] Sci Signal. 2008;1(22):re4 [18523239] Carcinogenesis. 2009 Sep;30(9):1620-7 [19587094] Cell Mol Life Sci. 2009 Sep;66(18):2953-73 [19597700] Mol Cancer Res. 2010 Apr;8(4):569-77 [20353998] Cell. 1987 Apr 10;49(1):1-4 [3030562] Proc Natl Acad Sci U S A. 1987 Dec;84(24):8879-82 [2827157] Pharmacol Rev. 2010 Jun;62(2):305-30 [20427692] Nature. 1999 Dec 23-30;402(6764):884-8 [10622253] Annu Rev Biochem. 2000;69:145-82 [10966456] Mol Pharmacol. 2000 Dec;58(6):1279-86 [11093764] Biochem Biophys Res Commun. 2001 Feb 16;281(1):25-31 [11178955] Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2449-54 [11226259] Annu Rev Pharmacol Toxicol. 2001;41:661-90 [11264472] Oncogene. 2001 Mar 26;20(13):1594-600 [11313906] J Biol Chem. 2001 Jun 22;276(25):23155-60 [11290747] J Biol Chem. 2001 Aug 31;276(35):32648-56 [11418617] Nat Med. 2001 Sep;7(9):1048-51 [11533709] J Biol Chem. 2002 Jan 11;277(2):1340-8 [11694504] J Biol Chem. 2002 Jan 25;277(4):2945-50 [11723127] Cancer Res. 2002 Jan 15;62(2):506-11 [11809702] Nat Med. 2002 Mar;8(3):289-93 [11875501] Cancer Res. 2002 Jun 15;62(12):3395-401 [12067981] J Environ Pathol Toxicol Oncol. 2002;21(2):183-91 [12086405] Trends Pharmacol Sci. 2003 Jul;24(7):335-40 [12871665] Cancer Metastasis Rev. 2003 Dec;22(4):337-58 [12884910] J Biol Chem. 2003 Sep 12;278(37):35451-7 [12824187] Life Sci. 2003 Dec 5;74(2-3):143-53 [14607241] J Clin Invest. 2004 Sep;114(5):720-8 [15343391] Oncogene. 2004 Oct 18;23(48):7969-78 [15489914] Oncogene. 2004 Oct 18;23(48):8017-23 [15489919] EMBO J. 1997 Dec 1;16(23):7032-44 [9384582] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M110.117689 ER - TY - JOUR T1 - β-Barrel topology of Alzheimer's β-amyloid ion channels. AN - 812131108; 20970427 AB - Emerging evidence supports the ion channel mechanism for Alzheimer's disease pathophysiology wherein small β-amyloid (Aβ) oligomers insert into the cell membrane, forming toxic ion channels and destabilizing the cellular ionic homeostasis. Solid-state NMR-based data of amyloid oligomers in solution indicate that they consist of a double-layered β-sheets where each monomer folds into β-strand-turn-β-strand and the monomers are stacked atop each other. In the membrane, Aβ peptides are proposed to be β-type structures. Experimental structural data available from atomic force microscopy (AFM) imaging of Aβ oligomers in membranes reveal heterogeneous channel morphologies. Previously, we modeled the channels in a non-tilted organization, parallel with the cross-membrane normal. Here, we modeled a β-barrel-like organization. β-Barrels are common in transmembrane toxin pores, typically consisting of a monomeric chain forming a pore, organized in a single-layered β-sheet with antiparallel β-strands and a right-handed twist. Our explicit solvent molecular dynamics simulations of a range of channel sizes and polymorphic turns and comparisons of these with AFM image dimensions support a β-barrel channel organization. Different from the transmembrane β-barrels where the monomers are folded into a circular β-sheet with antiparallel β-strands stabilized by the connecting loops, these Aβ barrels consist of multimeric chains forming double β-sheets with parallel β-strands, where the strands of each monomer are connected by a turn. Although the Aβ barrels adopt the right-handed β-sheet twist, the barrels still break into heterogeneous, loosely attached subunits, in good agreement with AFM images and previous modeling. The subunits appear mobile, allowing unregulated, hence toxic, ion flux. Copyright © 2010 Elsevier Ltd. All rights reserved. JF - Journal of molecular biology AU - Jang, Hyunbum AU - Arce, Fernando Teran AU - Ramachandran, Srinivasan AU - Capone, Ricardo AU - Lal, Ratnesh AU - Nussinov, Ruth AD - Center for Cancer Research Nanobiology Program, SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, MD 21702, USA. Y1 - 2010/12/17/ PY - 2010 DA - 2010 Dec 17 SP - 917 EP - 934 VL - 404 IS - 5 KW - Amyloid beta-Peptides KW - 0 KW - Ion Channels KW - Macromolecular Substances KW - Index Medicus KW - Animals KW - Protein Structure, Secondary KW - Models, Molecular KW - Humans KW - Microscopy, Atomic Force KW - Molecular Dynamics Simulation KW - Macromolecular Substances -- chemistry KW - Protein Multimerization KW - Protein Structure, Quaternary KW - Ion Channels -- chemistry KW - Amyloid beta-Peptides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/812131108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=%CE%B2-Barrel+topology+of+Alzheimer%27s+%CE%B2-amyloid+ion+channels.&rft.au=Jang%2C+Hyunbum%3BArce%2C+Fernando+Teran%3BRamachandran%2C+Srinivasan%3BCapone%2C+Ricardo%3BLal%2C+Ratnesh%3BNussinov%2C+Ruth&rft.aulast=Jang&rft.aufirst=Hyunbum&rft.date=2010-12-17&rft.volume=404&rft.issue=5&rft.spage=917&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=1089-8638&rft_id=info:doi/10.1016%2Fj.jmb.2010.10.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-21 N1 - Date created - 2010-11-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jmb.2010.10.025 ER - TY - JOUR T1 - Synthesis of novel cyclic NGR/RGD peptide analogs via on resin click chemistry AN - 954590973; 13997433 AB - Targeted drug deliveries as well as high resolution imaging of cancerous tissues and organs via specific cancer cell markers have become important in chemotherapeutic interventions of cancer treatment. Short peptides such as RGD and NGR are showing promising results for targeted drug delivery and in vivo imaging. We have applied on resin Huisgen's 1,3-dipolar cycloaddition to synthesize new cyclic RGD and NGR peptide analogs. Preliminary binding assays of these new analogs by fluorescence polarization indicates specific binding to purified CD13 (Aminopeptidase N) and cell lysates from MCF-7 and SKOV-3 cancer cell lines. JF - Bioorganic and Medicinal Chemistry Letters AU - Metaferia, Belhu B AU - Rittler, Matthew AU - Gheeya, Jinesh S AU - Lee, Albert AU - Hempel, Heidi AU - Plaza, Alberto AU - Stetler-Stevenson, William G AU - Bewley, Carole A AU - Khan, Javed AD - Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, khanjav@mail.nih.gov Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 7337 EP - 7340 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 20 IS - 24 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - CD13 antigen KW - Drug delivery KW - Aminopeptidase KW - Resins KW - Tumor cell lines KW - imaging KW - Cancer KW - Fluorescence polarization KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954590973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Synthesis+of+novel+cyclic+NGR%2FRGD+peptide+analogs+via+on+resin+click+chemistry&rft.au=Metaferia%2C+Belhu+B%3BRittler%2C+Matthew%3BGheeya%2C+Jinesh+S%3BLee%2C+Albert%3BHempel%2C+Heidi%3BPlaza%2C+Alberto%3BStetler-Stevenson%2C+William+G%3BBewley%2C+Carole+A%3BKhan%2C+Javed&rft.aulast=Metaferia&rft.aufirst=Belhu&rft.date=2010-12-15&rft.volume=20&rft.issue=24&rft.spage=7337&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2010.10.064 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - CD13 antigen; Aminopeptidase; Drug delivery; Tumor cell lines; Resins; imaging; Cancer; Fluorescence polarization DO - http://dx.doi.org/10.1016/j.bmcl.2010.10.064 ER - TY - JOUR T1 - Metabolic syndrome affects breast cancer risk in postmenopausal women: National Cancer Institute of Naples experience. AN - 840347569; 20935521 AB - Postmenopausal women show the highest incidence of breast cancer in the female population and are often affected by metabolic syndrome. Metabolic syndrome (MS)--characterized by central adiposity, insulin resistance, low serum high-density lipoprotein cholesterol (HDL-C), high serum triglyceride and high blood pressure--seems to be strictly correlated to breast carcinogenesis. We enrolled 777 healthy women and women with breast cancer in our nested case-control study to evaluate the association between MS and breast cancer, analyzing anthropometric parameters (weight, height, BMI, waist and hip circumference), blood pressure, serum HDL-C, triglyceride, fasting plasma glucose, insulin, testosterone and uric acid levels and administering a questionnaire about physical activity, food intake, tobacco use, alcohol abuse, personal and familial history of disease. We found an higher prevalence of metabolic syndrome (30%) in postmenopausal breast cancer patients compared to healthy women (19%). None of the individual MS features was strong enough to be considered responsible for breast carcinogenesis alone. However, of the 63 postmenopausal breast cancer cases associated to MS, 30% presented three or more MS features, suggesting that the activation of multiple molecular pathways underlying MS might contribute to tumorigenesis. Our data support the hypothesis that MS may be an indicator of breast cancer risk in postmenopausal women. The unsettlement of the hormonal arrangement in postmenopausal, along with an increase in visceral adiposity, probably favour the hormone-dependent cell proliferation, which drives tumorigenesis. Adjustments in lifestyle with physical activity intensification and healthy diet could represent modifiable factors for the primary prevention of sporadic breast cancer. JF - Cancer biology & therapy AU - Capasso, Immacolata AU - Esposito, Emanuela AU - Pentimalli, Francesca AU - Crispo, Anna AU - Montella, Maurizio AU - Grimaldi, Maria AU - De Marco, MariaRosaria AU - Cavalcanti, Ernestina AU - D'Aiuto, Massimiliano AU - Fucito, Alfredo AU - Frasci, Giuseppe AU - Maurea, Nicola AU - Esposito, Giuseppe AU - Pedicini, Tonino AU - Vecchione, Aldo AU - D'Aiuto, Giuseppe AU - Giordano, Antonio AD - Department of Senology, National Cancer Institute of Naples, G.Pascale, Italy. icapasso@tiscali.it Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 1240 EP - 1243 VL - 10 IS - 12 KW - Blood Glucose KW - 0 KW - Cholesterol, HDL KW - Insulin KW - Triglycerides KW - Uric Acid KW - 268B43MJ25 KW - Testosterone KW - 3XMK78S47O KW - Index Medicus KW - Triglycerides -- blood KW - Blood Pressure KW - Body Height KW - Insulin -- blood KW - Humans KW - Aged KW - Blood Glucose -- analysis KW - Body Mass Index KW - Life Style KW - Body Weight KW - Smoking KW - Cholesterol, HDL -- blood KW - Risk Factors KW - Testosterone -- blood KW - Motor Activity KW - Adult KW - Alcoholism KW - Surveys and Questionnaires KW - Case-Control Studies KW - Middle Aged KW - Uric Acid -- blood KW - Female KW - Body Size KW - Postmenopause KW - Breast Neoplasms -- etiology KW - Metabolic Syndrome X -- epidemiology KW - Breast Neoplasms -- epidemiology KW - Metabolic Syndrome X -- blood KW - Breast Neoplasms -- blood KW - Metabolic Syndrome X -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/840347569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=Metabolic+syndrome+affects+breast+cancer+risk+in+postmenopausal+women%3A+National+Cancer+Institute+of+Naples+experience.&rft.au=Capasso%2C+Immacolata%3BEsposito%2C+Emanuela%3BPentimalli%2C+Francesca%3BCrispo%2C+Anna%3BMontella%2C+Maurizio%3BGrimaldi%2C+Maria%3BDe+Marco%2C+MariaRosaria%3BCavalcanti%2C+Ernestina%3BD%27Aiuto%2C+Massimiliano%3BFucito%2C+Alfredo%3BFrasci%2C+Giuseppe%3BMaurea%2C+Nicola%3BEsposito%2C+Giuseppe%3BPedicini%2C+Tonino%3BVecchione%2C+Aldo%3BD%27Aiuto%2C+Giuseppe%3BGiordano%2C+Antonio&rft.aulast=Capasso&rft.aufirst=Immacolata&rft.date=2010-12-15&rft.volume=10&rft.issue=12&rft.spage=1240&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=1555-8576&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-26 N1 - Date created - 2011-01-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Platelet aggregation inhibitors from hematophagous animals AN - 831190368; 13890717 AB - Salivary glands from blood-sucking animals (e.g., mosquitoes, bugs, sand flies, fleas, ticks, leeches, hookworms, bats) are a rich source of bioactive molecules that counteract hemostasis in a redundant and synergistic manner. This review discusses recent progress in the identification of salivary inhibitors of platelet aggregation, their molecular characterization, and detailed mechanism of action. Diversity of inhibitors is remarkable, with distinct families of proteins characterized as apyrases that enzymatically degrade ADP or as collagen-binding proteins that prevent its interaction with vWF, or platelet integrin a2b1 or GPVI. Molecules that bind ADP, TXA2, epinephrine, or serotonin with high affinity have also been cloned, expressed, and their structure determined. In addition, a repertoire of antithrombins and an increasingly number of RGD and non-RGD disintegrins targeting platelet aIIbb3 have been reported. Moreover, metalloproteases with fibrinogen(olytic) activity and PAF phosphorylcholine hydrolase are enzymes that have been recruited to the salivary gland to block platelet aggregation. Platelet inhibitory prostaglandins, lysophosphatydilcholine, adenosine, and nitric oxide (NO)-carrying proteins are other notable examples of molecules from hematophagous salivary secretions (herein named sialogenins) with antihemostatic properties. Sialogenins have been employed as tools in biochemistry and cell biology and also display potential therapeutic applications. JF - Toxicon AU - Francischetti, Ivo MB AD - Vector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8132, USA, ifrancischetti@niaid.nih.gov Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 1130 EP - 1144 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 56 IS - 7 SN - 0041-0101, 0041-0101 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Toxicology Abstracts KW - Platelet aggregation KW - Hematophagy KW - Thrombosis KW - Vascular biology KW - Sialogenins KW - Secretion KW - Secretions KW - Therapeutic applications KW - Salivary gland KW - Hirudinea KW - Apyrase KW - Collagen KW - Platelet-activating factor KW - Integrins KW - phosphorylcholine KW - Glands KW - Inhibitors KW - Cytology KW - Epinephrine KW - Aquatic insects KW - antithrombin KW - Ixodidae KW - Prostaglandins KW - Enzymes KW - Aggregation KW - Hydrolases KW - Serotonin KW - Metalloproteinase KW - hydrolase KW - ADP KW - hemostasis KW - Species diversity KW - Nitric oxide KW - Adenosine KW - Q1 08484:Species interactions: parasites and diseases KW - X 24360:Metals KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/831190368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Platelet+aggregation+inhibitors+from+hematophagous+animals&rft.au=Francischetti%2C+Ivo+MB&rft.aulast=Francischetti&rft.aufirst=Ivo&rft.date=2010-12-15&rft.volume=56&rft.issue=7&rft.spage=1130&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2009.12.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - ADP; Secretion; Glands; Species diversity; Aggregation; Cytology; Inhibitors; Hydrolases; Aquatic insects; Platelet aggregation; Prostaglandins; Secretions; Therapeutic applications; Enzymes; Salivary gland; Apyrase; Serotonin; Collagen; hydrolase; Platelet-activating factor; Metalloproteinase; Integrins; hemostasis; phosphorylcholine; Nitric oxide; Epinephrine; Adenosine; antithrombin; Ixodidae; Hirudinea DO - http://dx.doi.org/10.1016/j.toxicon.2009.12.003 ER - TY - JOUR T1 - Structure and mechanism in salivary proteins from blood-feeding arthropods AN - 831186922; 13890718 AB - The saliva of blood-feeding arthropods contains rich mixtures of ligand binding proteins targeted at inhibiting hemostasis and inflammation in the host. Since blood feeding has evolved many times, different taxonomic groups utilize completely different families of proteins to perform similar tasks. Structural studies performed on a number of these proteins have revealed biologically novel and sophisticated mechanisms used to perform their functions. Here, the results of these structural and mechanistic studies are reviewed. JF - Toxicon AU - Andersen, John F AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 2E-32B Twinbrook 3 Bldg, 12735 Twinbrook Parkway, Rockville, MD 20852, USA, jandersen@niaid.nih.gov Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 1120 EP - 1129 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 56 IS - 7 SN - 0041-0101, 0041-0101 KW - Toxicology Abstracts KW - Lipocalin KW - Odorant-binding protein KW - D7 KW - Nitrophorin KW - Tick KW - Mosquito KW - Diptera KW - X-ray crystallography KW - NO KW - NP KW - OBP KW - Feeding KW - Blood KW - Arthropoda KW - hemostasis KW - Reviews KW - Saliva KW - Inflammation KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/831186922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Structure+and+mechanism+in+salivary+proteins+from+blood-feeding+arthropods&rft.au=Andersen%2C+John+F&rft.aulast=Andersen&rft.aufirst=John&rft.date=2010-12-15&rft.volume=56&rft.issue=7&rft.spage=1120&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2009.11.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Blood; Feeding; hemostasis; Reviews; Saliva; Inflammation; Arthropoda DO - http://dx.doi.org/10.1016/j.toxicon.2009.11.002 ER - TY - JOUR T1 - A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients. AN - 818640345; 21159642 AB - Metastasis-related recurrence often occurs in hepatocellular carcinoma (HCC) patients who receive curative therapies. At present, it is challenging to identify patients with high risk of recurrence, which would warrant additional therapies. In this study, we sought to analyze a recently developed metastasis-related gene signature for its utility in predicting HCC survival, using 2 independent cohorts consisting of a total of 386 patients who received radical resection. Cohort 1 contained 247 predominantly HBV-positive cases analyzed with an Affymetrix platform, whereas cohort 2 contained 139 cases with mixed etiology analyzed with the NCI Oligo Set microarray platform. We employed a survival risk prediction algorithm with training, test, and independent cross-validation strategies and found that the gene signature is predictive of overall and disease-free survival. Importantly, risk was significantly predicted independently of clinical characteristics and microarray platform. In addition, survival prediction was successful in patients with early disease, such as small (<5 cm in diameter) and solitary tumors, and the signature predicted particularly well for early recurrence risk (<2 years), especially when combined with serum alpha fetoprotein or tumor staging. In conclusion, we have shown in 2 independent cohorts with mixed etiologies and ethnicity that the metastasis gene signature is a useful tool to predict HCC outcome, suggesting the general utility of this classifier. We recommend the use of this classifier as a molecular diagnostic test to assess the risk that an HCC patient will develop tumor relapse within 2 years after surgical resection, particularly for those with early-stage tumors and solitary presentation. ©2010 AACR. JF - Cancer research AU - Roessler, Stephanie AU - Jia, Hu-Liang AU - Budhu, Anuradha AU - Forgues, Marshonna AU - Ye, Qing-Hai AU - Lee, Ju-Seog AU - Thorgeirsson, Snorri S AU - Sun, Zhongtang AU - Tang, Zhao-You AU - Qin, Lun-Xiu AU - Wang, Xin Wei AD - Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 10202 EP - 10212 VL - 70 IS - 24 KW - Index Medicus KW - Sensitivity and Specificity KW - Reproducibility of Results KW - Risk Factors KW - Humans KW - Cohort Studies KW - Prognosis KW - Neoplasm Metastasis KW - Gene Expression KW - Middle Aged KW - Proportional Hazards Models KW - Liver Neoplasms -- pathology KW - Carcinoma, Hepatocellular -- genetics KW - Carcinoma, Hepatocellular -- pathology KW - Neoplasm Recurrence, Local -- genetics KW - Neoplasm Recurrence, Local -- pathology KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/818640345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=A+unique+metastasis+gene+signature+enables+prediction+of+tumor+relapse+in+early-stage+hepatocellular+carcinoma+patients.&rft.au=Roessler%2C+Stephanie%3BJia%2C+Hu-Liang%3BBudhu%2C+Anuradha%3BForgues%2C+Marshonna%3BYe%2C+Qing-Hai%3BLee%2C+Ju-Seog%3BThorgeirsson%2C+Snorri+S%3BSun%2C+Zhongtang%3BTang%2C+Zhao-You%3BQin%2C+Lun-Xiu%3BWang%2C+Xin+Wei&rft.aulast=Roessler&rft.aufirst=Stephanie&rft.date=2010-12-15&rft.volume=70&rft.issue=24&rft.spage=10202&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-10-2607 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-20 N1 - Date created - 2010-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 2000 Jan 7;100(1):57-70 [10647931] Nat Med. 2009 May;15(5):559-65 [19363497] J Hepatol. 2009 Nov;51(5):890-7 [19747749] Nat Rev Clin Oncol. 2010 Jun;7(6):340-7 [20440284] Cancer. 2000 Aug 1;89(3):500-7 [10931448] Gastroenterology. 2000 Aug;119(2):431-40 [10930378] Histopathology. 2001 Jul;39(1):66-73 [11454046] World J Gastroenterol. 2001 Aug;7(4):445-54 [11819809] J Natl Cancer Inst. 2002 Jul 3;94(13):981-90 [12096083] N Engl J Med. 2002 Dec 19;347(25):1999-2009 [12490681] J Hepatol. 2003 Feb;38(2):200-7 [12547409] Nat Med. 2003 Apr;9(4):416-23 [12640447] Nat Rev Cancer. 2003 Jun;3(6):453-8 [12778135] Biostatistics. 2003 Apr;4(2):249-64 [12925520] J Am Coll Surg. 2003 Nov;197(5):753-8 [14585409] J Hepatol. 2004 Jan;40(1):124-31 [14672623] Br J Surg. 2004 Apr;91(4):400-8 [15048738] Hepatology. 2004 Sep;40(3):667-76 [15349906] Br J Surg. 1988 Mar;75(3):203-6 [2832032] Surgery. 1997 Sep;122(3):571-7 [9308615] Hepatology. 1998 Sep;28(3):751-5 [9731568] Semin Liver Dis. 1999;19(3):329-38 [10518312] N Engl J Med. 2004 Dec 30;351(27):2817-26 [15591335] Bioinformatics. 2005 Oct 15;21(20):3940-1 [16096348] Hepatology. 2005 Nov;42(5):1208-36 [16250051] Ann Surg. 2006 Feb;243(2):229-35 [16432356] Nat Med. 2006 Apr;12(4):410-6 [16532004] Gastroenterology. 2007 Jun;132(7):2557-76 [17570226] Oncogene. 2007 Sep 27;26(44):6361-71 [17452979] Cancer Res. 2008 Mar 1;68(5):1451-61 [18316609] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4283-8 [18337506] N Engl J Med. 2008 Jul 24;359(4):378-90 [18650514] N Engl J Med. 2008 Nov 6;359(19):1995-2004 [18923165] N Engl J Med. 2008 Nov 6;359(19):2045-7 [18923166] Hepatology. 2008 Dec;48(6):1834-42 [18972404] Lancet Oncol. 2009 Jan;10(1):25-34 [19095497] Ann Surg Oncol. 2009 Apr;16(4):792-4 [19190964] J Clin Oncol. 2009 Mar 20;27(9):1485-91 [19224838] Expert Rev Gastroenterol Hepatol. 2009 Apr;3(2):101-3 [19351279] Clin Cancer Res. 2009 Apr 15;15(8):2588-93 [19351761] N Engl J Med. 2009 Oct 8;361(15):1437-47 [19812400] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-10-2607 ER - TY - JOUR T1 - Global Gene Expression Profiling of a Population Exposed to a Range of Benzene Levels AN - 883024197; 15090571 AB - Benzene, an established cause of acute myeloid leukemia (AML), may also cause one or more lymphoid malignancies in humans. Previously, we identified genes and pathways associated with exposure to high (> 10 ppm) levels of benzene through transcriptomic analyses of blood cells from a small number of occupationally exposed workers. The goals of this study were to identify potential biomarkers of benzene exposure and/or early effects and to elucidate mechanisms relevant to risk of hematotoxicity, leukemia, and lymphoid malignancy in occupationally exposed individuals, many of whom were exposed to benzene levels & 1 ppm, the current U.S. occupational standard. We analyzed global gene expression in the peripheral blood mononuclear cells of 125 workers exposed to benzene levels ranging from & 1 ppm to > 10 ppm. Study design and analysis with a mixed-effects model minimized potential confounding and experimental variability. We observed highly significant widespread perturbation of gene expression at all exposure levels. The AML pathway was among the pathways most significantly associated with benzene exposure. Immune response pathways were associated with most exposure levels, potentially providing biological plausibility for an association between lymphoma and benzene exposure. We identified a 16-gene expression signature associated with all levels of benzene exposure. Our findings suggest that chronic benzene exposure, even at levels below the current U.S. occupational standard, perturbs many genes, biological processes, and pathways. These findings expand our understanding of the mechanisms by which benzene may induce hematotoxicity, leukemia, and lymphoma and reveal relevant potential biomarkers associated with a range of exposures. JF - Environmental Health Perspectives AU - McHale, Cliona M AU - Zhang, Luoping AU - Lan, Qing AU - Vermeulen, Roel AU - Li, Guilan AU - Hubbard, Alan E AU - Porter, Kristin E AU - Thomas, Reuben AU - Portier, Christopher J AU - Shen, Min AU - Rappaport, Stephen M AU - Yin, Songnian AU - Smith, Martyn T AU - Rothman, Nathaniel AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2010/12/13/ PY - 2010 DA - 2010 Dec 13 SP - 628 EP - 640 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 119 IS - 5 SN - 0091-6765, 0091-6765 KW - Genetics Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts; Risk Abstracts; Environment Abstracts KW - benzene KW - biomarker KW - human KW - microarray KW - transcriptomics KW - Bioindicators KW - Acute myeloid leukemia KW - biomarkers KW - Benzene KW - Gene expression KW - Leukemia KW - USA KW - Malignancy KW - Peripheral blood mononuclear cells KW - Blood cells KW - Immune response KW - lymphoma KW - Lymphoma KW - Occupational exposure KW - G 07720:Immunogenetics KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health KW - X 24350:Industrial Chemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883024197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Global+Gene+Expression+Profiling+of+a+Population+Exposed+to+a+Range+of+Benzene+Levels&rft.au=McHale%2C+Cliona+M%3BZhang%2C+Luoping%3BLan%2C+Qing%3BVermeulen%2C+Roel%3BLi%2C+Guilan%3BHubbard%2C+Alan+E%3BPorter%2C+Kristin+E%3BThomas%2C+Reuben%3BPortier%2C+Christopher+J%3BShen%2C+Min%3BRappaport%2C+Stephen+M%3BYin%2C+Songnian%3BSmith%2C+Martyn+T%3BRothman%2C+Nathaniel&rft.aulast=McHale&rft.aufirst=Cliona&rft.date=2010-12-13&rft.volume=119&rft.issue=5&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002546 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Gene expression; Peripheral blood mononuclear cells; Malignancy; Acute myeloid leukemia; Immune response; Blood cells; Lymphoma; biomarkers; Occupational exposure; Benzene; Bioindicators; Leukemia; lymphoma; USA DO - http://dx.doi.org/10.1289/ehp.1002546 ER - TY - JOUR T1 - Characterization of ductal and lobular breast carcinomas using novel prolactin receptor isoform specific antibodies. AN - 821485812; 21144038 AB - Prolactin is a polypeptide hormone responsible for proliferation and differentiation of the mammary gland. More recently, prolactin's role in mammary carcinogenesis has been studied with greater interest. Studies from our laboratory and from others have demonstrated that three specific isoforms of the prolactin receptor (PRLR) are expressed in both normal and cancerous breast cells and tissues. Until now, reliable isoform specific antibodies have been lacking. We have prepared and characterized polyclonal antibodies against each of the human PRLR isoforms that can effectively be used to characterize human breast cancers. Rabbits were immunized with synthetic peptides of isoform unique regions and immune sera affinity purified prior to validation by Western blot and immunohistochemical analyses. Sections of ductal and lobular carcinomas were stained with each affinity purified isoform specific antibody to determine expression patterns in breast cancer subclasses. We show that the rabbit antibodies have high titer and could specifically recognize each isoform of PRLR. Differences in PRLR isoform expression levels were observed and quantified using histosections from xenografts of established human breast cancer cells lines, and ductal and lobular carcinoma human biopsy specimens. In addition, these results were verified by real-time PCR with isoform specific primers. While nearly all tumors contained LF and SF1b, the majority (76%) of ductal carcinoma biopsies expressed SF1a while the majority of lobular carcinomas lacked SF1a staining (72%) and 27% had only low levels of expression. Differences in the receptor isoform expression profiles may be critical to understanding the role of PRL in mammary tumorigenesis. Since these antibodies are specifically directed against each PRLR isoform, they are valuable tools for the evaluation of breast cancer PRLR content and have potential clinical importance in treatment of this disease by providing new reagents to study the protein expression of the human PRLR. JF - BMC cancer AU - Ginsburg, Erika AU - Alexander, Stefanie AU - Lieber, Sarah AU - Tarplin, Sarah AU - Jenkins, Luwanda AU - Pang, Linda AU - Heger, Christopher D AU - Goldsmith, Paul AU - Vonderhaar, Barbara K AD - Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. eg20e@nih.gov Y1 - 2010/12/13/ PY - 2010 DA - 2010 Dec 13 SP - 678 VL - 10 KW - Antibodies KW - 0 KW - Protein Isoforms KW - RNA, Messenger KW - Receptors, Prolactin KW - Index Medicus KW - Animals KW - Cricetulus KW - Humans KW - Rabbits KW - Biopsy KW - Cell Line, Tumor KW - Mice KW - Mice, Nude KW - Reverse Transcriptase Polymerase Chain Reaction KW - Antibody Specificity KW - Blotting, Western KW - RNA, Messenger -- metabolism KW - Transfection KW - CHO Cells KW - Female KW - Cricetinae KW - Breast Neoplasms -- genetics KW - Receptors, Prolactin -- metabolism KW - Carcinoma, Lobular -- metabolism KW - Carcinoma, Ductal, Breast -- metabolism KW - Receptors, Prolactin -- immunology KW - Breast Neoplasms -- metabolism KW - Receptors, Prolactin -- genetics KW - Immunohistochemistry KW - Carcinoma, Lobular -- genetics KW - Carcinoma, Ductal, Breast -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821485812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+cancer&rft.atitle=Characterization+of+ductal+and+lobular+breast+carcinomas+using+novel+prolactin+receptor+isoform+specific+antibodies.&rft.au=Ginsburg%2C+Erika%3BAlexander%2C+Stefanie%3BLieber%2C+Sarah%3BTarplin%2C+Sarah%3BJenkins%2C+Luwanda%3BPang%2C+Linda%3BHeger%2C+Christopher+D%3BGoldsmith%2C+Paul%3BVonderhaar%2C+Barbara+K&rft.aulast=Ginsburg&rft.aufirst=Erika&rft.date=2010-12-13&rft.volume=10&rft.issue=&rft.spage=678&rft.isbn=&rft.btitle=&rft.title=BMC+cancer&rft.issn=1471-2407&rft_id=info:doi/10.1186%2F1471-2407-10-678 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-31 N1 - Date created - 2010-12-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2001 Nov 2;276(44):41086-94 [11518703] Mol Endocrinol. 2001 May;15(5):819-31 [11328861] J Mol Endocrinol. 2003 Feb;30(1):31-47 [12580759] Endocr Rev. 2003 Feb;24(1):1-27 [12588805] JAMA. 2003 Mar 19;289(11):1421-4 [12636465] Mol Biol Cell. 2004 Jun;15(6):2523-36 [15034139] Cancer Res. 2004 Aug 15;64(16):5677-82 [15313907] Cancer Res. 2004 Sep 15;64(18):6814-9 [15375001] Anal Biochem. 1976 May 7;72:248-54 [942051] Eur J Cancer Clin Oncol. 1982 Nov;18(11):1157-62 [6297917] Proc Natl Acad Sci U S A. 1986 Apr;83(7):2258-62 [3083418] Cancer Res. 1987 Jul 1;47(13):3509-14 [3581086] FEBS Lett. 1989 Jun 5;249(2):189-94 [2500363] Int J Cancer. 1993 Nov 11;55(5):712-21 [7503956] Cancer. 1994 Mar 15;73(6):1673-7 [8156495] Br J Cancer. 1997;76(9):1234-40 [9365176] J Natl Cancer Inst. 1999 Apr 7;91(7):629-34 [10203283] Cancer Res. 1959 Jun;19(5):515-20 [13663040] Mol Cell Endocrinol. 2005 Mar 31;232(1-2):9-19 [15737464] Mol Endocrinol. 2005 May;19(5):1291-303 [15695371] Ann Surg. 2005 Aug;242(2):281-9 [16041220] Cancer Res. 2005 Aug 15;65(16):7509-15 [16103106] Endocr Relat Cancer. 2006 Mar;13(1):95-111 [16601282] Mol Endocrinol. 2006 Aug;20(8):1912-23 [16556730] J Clin Oncol. 2007 Apr 20;25(12):1482-8 [17372279] Biochemistry. 2008 Jan 8;47(1):479-89 [18081308] J Mammary Gland Biol Neoplasia. 2008 Mar;13(1):81-91 [18204982] BMC Cell Biol. 2008;9:46 [18710550] J Endocrinol. 2009 Apr;201(1):115-28 [19153125] Mod Pathol. 2009 Oct;22(10):1273-9 [19633648] Prostate. 2010 Jan 1;70(1):37-47 [19739126] J Mol Endocrinol. 2010 Mar;44(3):187-94 [19906835] Br J Cancer. 2010 Sep 28;103(7):1097-102 [20736944] J Clin Pathol. 2001 Dec;54(12):956-60 [11729217] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2407-10-678 ER - TY - JOUR T1 - Moving Forward in Human Cancer Risk Assessment AN - 1677921891; 15090549 AB - The current safety paradigm for assessing carcinogenic properties of drugs, cosmetics, industrial chemicals, and environmental exposures relies mainly on in vitro genotoxicity testing followed by 2-year rodent bioassays. This testing battery is extremely sensitive but has low specificity. Furthermore, rodent bioassays are associated with high costs, high animal burden, and limited predictive value for human risks. We provide a response to a growing appeal for a paradigm change in human cancer risk assessment. To facilitate development of a road map for this needed paradigm change in carcinogenicity testing, a workshop titled "Genomics in Cancer Risk Assessment" brought together toxicologists from academia and industry and government regulators and risk assessors from the United States and the European Union. Participants discussed the state-of-the-art in developing alternative testing strategies for carcinogenicity, with emphasis on potential contributions from omics technologies. The goal of human risk assessment is to decide whether a given exposure to an agent is acceptable to human health and to provide risk management measures based on evaluating and predicting the effects of exposures on human health. Although exciting progress is being made using genomics approaches, a new paradigm that uses these methods and human material when possible would provide mechanistic insights that may inform new predictive approaches (e.g., in vitro assays) and facilitate the development of genomics-derived biomarkers. Regulators appear to be willing to accept such approaches where use is clearly defined, evidence is strong, and approaches are qualified for regulatory use. JF - Environmental Health Perspectives AU - Paules, Richard S AU - Aubrecht, Jiri AU - Corvi, Raffaella AU - Garthoff, Bernward AU - Kleinjans, Jos C AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2010/12/13/ PY - 2010 DA - 2010 Dec 13 SP - 739 EP - 743 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 119 IS - 6 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - cancer KW - human KW - omics technologies KW - risk assessment KW - systems biology KW - Risk assessment KW - Risk KW - In vitro testing KW - Human KW - Exposure KW - Health KW - Cancer KW - Bioassay UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677921891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Moving+Forward+in+Human+Cancer+Risk+Assessment&rft.au=Paules%2C+Richard+S%3BAubrecht%2C+Jiri%3BCorvi%2C+Raffaella%3BGarthoff%2C+Bernward%3BKleinjans%2C+Jos+C&rft.aulast=Paules&rft.aufirst=Richard&rft.date=2010-12-13&rft.volume=119&rft.issue=6&rft.spage=739&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002735 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1289/ehp.1002735 ER - TY - JOUR T1 - Using transgenic mouse models to study oxytocin's role in the facilitation of species propagation AN - 853475001; 14041937 AB - Oxytocin and its receptor are important for a wide range of effects, from social memory to uterine contractions. It is an evolutionarily well-conserved hormone that is particularly important in social and gregarious animals. Research on small mammals has yielded a rich literature on oxytocin's many functions. Recently a new tool has been created that has furthered our understanding of oxytocin's role in behavior: transgenic mice that lack either the ability to synthesize oxytocin or the oxytocin receptor itself. The study of these lines, while still in its infancy, is already bearing fruit and offers the promise of insight into some human disorders characterized by aberrant social behavior. JF - Brain Research AU - Lee, Heon-Jin AU - Pagani, Jerome AU - Young, WScott AD - Department of Dental Microbiology, School of Dentistry, Kyungpook National University, Daegu, South Korea, wsy@mail.nih.gov Y1 - 2010/12/10/ PY - 2010 DA - 2010 Dec 10 SP - 216 EP - 224 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1364 SN - 0006-8993, 0006-8993 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Fruits KW - Memory KW - Uterus KW - Oxytocin receptors KW - Social behavior KW - Animal models KW - Transgenic mice KW - Hormones KW - Evolution KW - Oxytocin KW - W 30925:Genetic Engineering KW - N3 11001:Behavioral and Cognitive Neuroscience KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853475001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Research&rft.atitle=Using+transgenic+mouse+models+to+study+oxytocin%27s+role+in+the+facilitation+of+species+propagation&rft.au=Lee%2C+Heon-Jin%3BPagani%2C+Jerome%3BYoung%2C+WScott&rft.aulast=Lee&rft.aufirst=Heon-Jin&rft.date=2010-12-10&rft.volume=1364&rft.issue=&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=Brain+Research&rft.issn=00068993&rft_id=info:doi/10.1016%2Fj.brainres.2010.08.042 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Fruits; Oxytocin receptors; Uterus; Memory; Animal models; Social behavior; Transgenic mice; Hormones; Evolution; Oxytocin DO - http://dx.doi.org/10.1016/j.brainres.2010.08.042 ER - TY - JOUR T1 - Alemtuzumab treatment of intermediate-1 myelodysplasia patients is associated with sustained improvement in blood counts and cytogenetic remissions. AN - 821597921; 21041705 AB - Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis and progression to leukemia. Clinical and experimental evidence suggests an immune-mediated pathophysiology in some patients, in whom immunosuppressive therapy (IST) with horse antithymocyte globulin (h-ATG) and cyclosporine (CsA) can be effective. Because of the toxicities associated with h-ATG/CsA, we investigated an alternative regimen with alemtuzumab in MDS. We conducted a nonrandomized, off-label, pilot, phase I/II study of alemtuzumab monotherapy in patients with MDS who were judged likely to respond to IST based on the following criteria: HLA-DR15-negative patients whose age plus the number of months of RBC transfusion dependence (RCTD) was less than 58; and HLA-DR15-positive patients whose age plus RCTD was less than 72. In total, 121 patients with MDS were screened, of whom 32 met eligibility criteria to receive alemtuzumab 10 mg/d intravenously for 10 days. Primary end points were hematologic responses at 3, 6, and 12 months after alemtuzumab. Seventeen (77%) of 22 evaluable intermediate-1 patients and four (57%) of seven evaluable intermediate-2 patients responded to treatment with a median time to response of 3 months. Four of seven evaluable responders with cytogenetic abnormalities before treatment had normal cytogenetics by 1 year after treatment. Five (56%) of nine responding patients evaluable at 12 months had normal blood counts, and seven (78%) of nine patients were transfusion independent. Alemtuzumab is safe and active in MDS and may be an attractive alternative to ATG in selected patients likely to respond to IST. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Sloand, Elaine M AU - Olnes, Matthew J AU - Shenoy, Aarthie AU - Weinstein, Barbara AU - Boss, Carol AU - Loeliger, Kelsey AU - Wu, Colin O AU - More, Kenneth AU - Barrett, A John AU - Scheinberg, Phillip AU - Young, Neal S AD - Hematology Branch, National Heart, Lung, and Blood Institute, Bldg 10 CRC 4-5230, Bethesda, MD 20892, USA. sloande@nhlbi.nih.gov Y1 - 2010/12/10/ PY - 2010 DA - 2010 Dec 10 SP - 5166 EP - 5173 VL - 28 IS - 35 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Antibodies, Neoplasm KW - Antineoplastic Agents KW - alemtuzumab KW - 3A189DH42V KW - Index Medicus KW - Kaplan-Meier Estimate KW - Young Adult KW - Off-Label Use KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Pilot Projects KW - Middle Aged KW - Male KW - Female KW - Myelodysplastic Syndromes -- drug therapy KW - Antibodies, Neoplasm -- therapeutic use KW - Myelodysplastic Syndromes -- mortality KW - Antineoplastic Agents -- therapeutic use KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821597921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Alemtuzumab+treatment+of+intermediate-1+myelodysplasia+patients+is+associated+with+sustained+improvement+in+blood+counts+and+cytogenetic+remissions.&rft.au=Sloand%2C+Elaine+M%3BOlnes%2C+Matthew+J%3BShenoy%2C+Aarthie%3BWeinstein%2C+Barbara%3BBoss%2C+Carol%3BLoeliger%2C+Kelsey%3BWu%2C+Colin+O%3BMore%2C+Kenneth%3BBarrett%2C+A+John%3BScheinberg%2C+Phillip%3BYoung%2C+Neal+S&rft.aulast=Sloand&rft.aufirst=Elaine&rft.date=2010-12-10&rft.volume=28&rft.issue=35&rft.spage=5166&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2010.29.7010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-20 N1 - Date created - 2010-12-14 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00217594; ClinicalTrials.gov N1 - SuppNotes - Cited By: Blood. 2006 Jul 15;108(2):419-25 [16609072] Haematologica. 2006 May;91(5):667-70 [16670072] Blood. 2007 Apr 15;109(8):3219-24 [17148582] Cancer. 2007 Apr 15;109(8):1536-42 [17345612] Leukemia. 2007 Jul;21(7):1436-41 [17507999] Cancer Res. 2007 Dec 1;67(23):11317-26 [18056458] Blood. 2008 Jan 1;111(1):86-93 [17893227] Arthritis Rheum. 2008 Feb;58(2):370-5 [18240243] Blood. 2008 May 1;111(9):4446-55 [18239083] J Clin Oncol. 2008 May 20;26(15):2505-11 [18413642] Br J Haematol. 2008 Jul;142(1):57-64 [18477045] J Clin Oncol. 1999 Dec;17(12):3835-49 [10577857] Br J Haematol. 2001 Sep;114(4):891-8 [11564082] Oncologist. 2002;7 Suppl 1:39-49 [11961208] J Clin Oncol. 2002 May 15;20(10):2429-40 [12011120] Br J Haematol. 2003 Feb;120(4):679-84 [12588356] JAMA. 2003 Mar 5;289(9):1130-5 [12622583] Leuk Lymphoma. 2003 Apr;44(4):593-604 [12769335] Blood. 2003 Oct 15;102(8):3025-7 [12829603] Leukemia. 2004 Mar;18(3):460-5 [14712285] Pediatr Transplant. 2004 Apr;8(2):106-12 [15049789] Leuk Lymphoma. 2004 Apr;45(4):711-4 [15160944] Blood. 2004 Jul 15;104(2):579-85 [15039286] Control Clin Trials. 1989 Mar;10(1):1-10 [2702835] Am J Med. 1991 Mar;90(3):338-44 [2003516] Gerontology. 1992;38(1-2):111-7 [1612458] Arthritis Rheum. 1995 Sep;38(9):1187-93 [7575711] Br J Rheumatol. 1996 Mar;35(3):231-40 [8620297] Br J Haematol. 1998 Feb;100(2):304-9 [9488617] J Clin Oncol. 2008 Jul 20;26(21):3607-13 [18559873] Leuk Res. 2009 Feb;33(2):222-31 [18790532] Haematologica. 2009 Jan;94(1):150-2 [19001286] Lancet Oncol. 2009 Mar;10(3):223-32 [19230772] Blood. 2009 Sep 10;114(11):2236-43 [19561322] Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14483-8 [16980411] Blood. 1998 Apr 1;91(7):2360-8 [9516135] Ren Fail. 1998 Sep;20(5):687-90 [9768435] Br J Haematol. 1999 Feb;104(2):271-4 [10050707] Philos Trans R Soc Lond B Biol Sci. 2005 Sep 29;360(1461):1707-11 [16147535] Comment In: J Clin Oncol. 2011 Dec 20;29(36):4841-2; author reply 4842 [22084365] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1200/JCO.2010.29.7010 ER - TY - JOUR T1 - Crystal structures of the glutamate receptor ion channel GluK3 and GluK5 amino-terminal domains. AN - 812132451; 20951142 AB - Ionotropic glutamate receptors (iGluRs) mediate the majority of fast excitatory synaptic neurotransmission in the central nervous system. The selective assembly of iGluRs into AMPA, kainate, and N-methyl-d-aspartic acid (NMDA) receptor subtypes is regulated by their extracellular amino-terminal domains (ATDs). Kainate receptors are further classified into low-affinity receptor families (GluK1-GluK3) and high-affinity receptor families (GluK4-GluK5) based on their affinity for the neurotoxin kainic acid. These two families share a 42% sequence identity for the intact receptor but only a 27% sequence identity at the level of ATD. We have determined for the first time the high-resolution crystal structures of GluK3 and GluK5 ATDs, both of which crystallize as dimers but with a strikingly different dimer assembly at the R1 interface. By contrast, for both GluK3 and GluK5, the R2 domain dimer assembly is similar to those reported previously for other non-NMDA iGluRs. This observation is consistent with the reports that GluK4-GluK5 cannot form functional homomeric ion channels and require obligate coassembly with GluK1-GluK3. Our analysis also reveals that the relative orientation of domains R1 and R2 in individual non-NMDA receptor ATDs varies by up to 10°, in contrast to the 50° difference reported for the NMDA receptor GluN2B subunit. This restricted domain movement in non-NMDA receptor ATDs seems to result both from extensive intramolecular contacts between domain R1 and domain R2 and from their assembly as dimers, which interact at both R1 and R2 domains. Our results provide the first insights into the structure and function of GluK4-GluK5, the least understood family of iGluRs. Copyright © 2010 Elsevier Ltd. All rights reserved. JF - Journal of molecular biology AU - Kumar, Janesh AU - Mayer, Mark L AD - Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2010/12/10/ PY - 2010 DA - 2010 Dec 10 SP - 680 EP - 696 VL - 404 IS - 4 KW - GluK3 kainate receptor KW - 0 KW - Gluk1 kainate receptor KW - Ion Channels KW - Receptors, Kainic Acid KW - Index Medicus KW - Rats KW - Animals KW - Models, Molecular KW - Crystallography, X-Ray KW - Protein Multimerization KW - Protein Structure, Quaternary KW - Receptors, Kainic Acid -- chemistry KW - Ion Channels -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/812132451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=Crystal+structures+of+the+glutamate+receptor+ion+channel+GluK3+and+GluK5+amino-terminal+domains.&rft.au=Kumar%2C+Janesh%3BMayer%2C+Mark+L&rft.aulast=Kumar&rft.aufirst=Janesh&rft.date=2010-12-10&rft.volume=404&rft.issue=4&rft.spage=680&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=1089-8638&rft_id=info:doi/10.1016%2Fj.jmb.2010.10.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-21 N1 - Date created - 2010-11-24 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 3OLZ; PDB; 3OM0; 3OM1 N1 - SuppNotes - Cited By: Nature. 1999 Dec 16;402(6763):817-21 [10617203] Neuropharmacology. 2011 Jan;60(1):135-50 [20713069] Neuron. 2000 Oct;28(1):165-81 [11086992] Neuron. 2000 Dec;28(3):911-25 [11163276] Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10037-41 [11517324] Science. 2001 Aug 31;293(5535):1657-62 [11533490] Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2660-5 [11867751] Nature. 2002 May 16;417(6886):245-53 [12015593] J Neurosci. 2002 Jul 15;22(14):5955-65 [12122058] Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13419-24 [12370423] J Neurosci. 2003 Jul 23;23(16):6608-16 [12878702] Methods Enzymol. 2003;374:229-44 [14696376] Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W615-9 [15215462] Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W665-7 [15215472] Annu Rev Pharmacol Toxicol. 1981;21:165-204 [6112965] Nature. 1991 Jun 27;351(6329):742-4 [1648176] Nature. 1991 Jun 27;351(6329):745-8 [1648177] Neuron. 1992 Feb;8(2):257-65 [1371217] EMBO J. 1992 Apr;11(4):1651-6 [1373382] Neuron. 1992 Apr;8(4):775-85 [1373632] Biochemistry. 1992 Nov 10;31(44):10657-63 [1420181] Neuron. 1993 Mar;10(3):491-500 [7681676] Neuron. 1997 Nov;19(5):1141-6 [9390526] Mol Pharmacol. 1999 Jun;55(6):957-69 [10347236] J Biol Chem. 1999 Oct 8;274(41):28937-43 [10506139] J Mol Biol. 1963 Jul;7:95-9 [13990617] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] Neuron. 2005 Feb 17;45(4):539-52 [15721240] J Biol Chem. 2005 Apr 15;280(15):15053-60 [15703162] Biopolymers. 2005;80(2-3):357-66 [15810013] Biochemistry. 2005 May 3;44(17):6597-608 [15850393] Nature. 2005 Nov 10;438(7065):185-92 [16281028] Acta Crystallogr D Biol Crystallogr. 2006 Apr;62(Pt 4):439-50 [16552146] Nature. 2006 Mar 23;440(7083):456-62 [16554805] J Neurosci. 2006 Jun 28;26(26):7014-21 [16807331] Neuron. 2007 Mar 15;53(6):829-41 [17359918] Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3759-64 [17360426] EMBO J. 2008 Aug 6;27(15):2158-70 [18636091] Curr Protoc Bioinformatics. 2002 Aug;Chapter 2:Unit 2.3 [18792934] Nature. 2009 Jun 4;459(7247):703-7 [19404260] EMBO J. 2009 Jun 17;28(12):1812-23 [19461580] Nat Struct Mol Biol. 2009 Jun;16(6):631-8 [19465914] J Mol Biol. 2009 Oct 9;392(5):1125-32 [19651138] J Neurosci. 2009 Sep 30;29(39):12045-58 [19793963] EMBO J. 2009 Dec 16;28(24):3910-20 [19910922] Nature. 2009 Dec 10;462(7274):745-56 [19946266] Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21 [20124702] Proc Natl Acad Sci U S A. 2010 May 4;107(18):8463-8 [20404149] Pharmacol Rev. 2010 Sep;62(3):405-96 [20716669] Mol Pharmacol. 2010 Oct;78(4):535-49 [20660085] Neuropharmacology. 2011 Jan;60(1):151-8 [20621105] Nature. 2000 Oct 26;407(6807):971-7 [11069170] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jmb.2010.10.006 ER - TY - JOUR T1 - Inflammasome Sensor Nlrp1b-Dependent Resistance to Anthrax Is Mediated by Caspase-1, IL-1 Signaling and Neutrophil Recruitment AN - 968157133; 14161889 AB - Bacillus anthracis infects hosts as a spore, germinates, and disseminates in its vegetative form. Production of anthrax lethal and edema toxins following bacterial outgrowth results in host death. Macrophages of inbred mouse strains are either sensitive or resistant to lethal toxin depending on whether they express the lethal toxin responsive or non-responsive alleles of the inflammasome sensor Nlrp1b (Nlrp1bS/S or Nlrp1bR/R, respectively). In this study, Nlrp1b was shown to affect mouse susceptibility to infection. Inbred and congenic mice harboring macrophage-sensitizing Nlrp1bS/S alleles (which allow activation of caspase-1 and IL-1 beta release in response to anthrax lethal toxin challenge) effectively controlled bacterial growth and dissemination when compared to mice having Nlrp1bR/R alleles (which cannot activate caspase-1 in response to toxin). Nlrp1bS-mediated resistance to infection was not dependent on the route of infection and was observed when bacteria were introduced by either subcutaneous or intravenous routes. Resistance did not occur through alterations in spore germination, as vegetative bacteria were also killed in Nlrp1bS/S mice. Resistance to infection required the actions of both caspase-1 and IL-1 beta as Nlrp1bS/S mice deleted of caspase-1 or the IL-1 receptor, or treated with the Il-1 receptor antagonist anakinra, were sensitized to infection. Comparison of circulating neutrophil levels and IL-1 beta responses in Nlrp1bS/S,Nlrp1bR/R and IL-1 receptor knockout mice implicated Nlrp1b and IL-1 signaling in control of neutrophil responses to anthrax infection. Neutrophil depletion experiments verified the importance of this cell type in resistance to B. anthracis infection. These data confirm an inverse relationship between murine macrophage sensitivity to lethal toxin and mouse susceptibility to spore infection, and establish roles for Nlrp1bS, caspase-1, and IL-1 beta in countering anthrax infection. In this study, we show that anthrax lethal toxin activation of Nlrp1b in toxin-sensitive mouse macrophages imparts resistance to infection. Inbred and congenic mice harboring macrophage-sensitizing Nlrp1b alleles control bacterial growth and dissemination independent of infection route or effects on germination efficiency. Knockout mice demonstrate that resistance imparted by Nlrp1b requires caspase-1 activity and IL-1 signaling. Mice in which lethal toxin activates the Nlrp1b inflammasome show an IL-1 beta response and increased neutrophil recruitment leading to increased resistance to infection. Neutrophil depletion experiments verify the importance of this cell type in resistance to B. anthracis infection. These data confirm an inverse relationship between murine macrophage sensitivity to lethal toxin and mouse susceptibility to spore infection and demonstrate that the activation of the inflammasome in response to anthrax infection in mice is a protective event that occurs through IL-1 beta induction of neutrophil recruitment. JF - PLoS Pathogens AU - Moayeri, Mahtab AU - Crown, Devorah AU - Newman, Zachary L AU - Okugawa, Shu AU - Eckhaus, Michael AU - Cataisson, Christophe AU - Liu, Shihui AU - Sastalla, Inka AU - Leppla, Stephen H AD - Laboratory of Bacterial Diseases, Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2010/12/09/ PY - 2010 DA - 2010 Dec 09 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 USA VL - 6 IS - 2 SN - 1553-7366, 1553-7366 KW - Immunology Abstracts; Toxicology Abstracts KW - Anthrax KW - Bacillus anthracis KW - Infection KW - X 24370:Natural Toxins KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968157133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Pathogens&rft.atitle=Inflammasome+Sensor+Nlrp1b-Dependent+Resistance+to+Anthrax+Is+Mediated+by+Caspase-1%2C+IL-1+Signaling+and+Neutrophil+Recruitment&rft.au=Moayeri%2C+Mahtab%3BCrown%2C+Devorah%3BNewman%2C+Zachary+L%3BOkugawa%2C+Shu%3BEckhaus%2C+Michael%3BCataisson%2C+Christophe%3BLiu%2C+Shihui%3BSastalla%2C+Inka%3BLeppla%2C+Stephen+H&rft.aulast=Moayeri&rft.aufirst=Mahtab&rft.date=2010-12-09&rft.volume=6&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Pathogens&rft.issn=15537366&rft_id=info:doi/10.1371%2Fjournal.ppat.1001222 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2014-03-20 N1 - SubjectsTermNotLitGenreText - Infection; Bacillus anthracis DO - http://dx.doi.org/10.1371/journal.ppat.1001222 ER - TY - JOUR T1 - Distribution and Pharmacokinetics of Methamphetamine in the Human Body: Clinical Implications AN - 968159708; 14161758 AB - Methamphetamine is one of the most toxic of the drugs of abuse, which may reflect its distribution and accumulation in the body. However no studies have measured methamphetamine's organ distribution in the human body. Positron Emission Tomography (PET) was used in conjunction with [11C]d-methamphetamine to measure its whole-body distribution and bioavailability as assessed by peak uptake (% Dose/cc), rate of clearance (time to reach 50% peak-clearance) and accumulation (area under the curve) in healthy participants (9 Caucasians and 10 African Americans). Methamphetamine distributed through most organs. Highest uptake (whole organ) occurred in lungs (22% Dose; weight similar to 1246 g), liver (23%; weight similar to 1677 g) and intermediate in brain (10%; weight similar to 1600 g). Kidneys also showed high uptake (per/cc basis) (7%; weight 305 g). Methamphetamine's clearance was fastest in heart and lungs (7-16 minutes), slowest in brain, liver and stomach (>75 minutes), and intermediate in kidneys, spleen and pancreas (22-50 minutes). Lung accumulation of [11C]d-methamphetamine was 30% higher for African Americans than Caucasians (p&0.05) but did not differ in other organs. The high accumulation of methamphetamine, a potent stimulant drug, in most body organs is likely to contribute to the medical complications associated with methamphetamine abuse. In particular, we speculate that methamphetamine's high pulmonary uptake could render this organ vulnerable to infections (tuberculosis) and pathology (pulmonary hypertension). Our preliminary findings of a higher lung accumulation of methamphetamine in African Americans than Caucasians merits further investigation and questions whether it could contribute to the infrequent use of methamphetamine among African Americans. JF - PLoS ONE AU - Volkow, Nora D AU - Fowler, Joanna S AU - Wang, Gene-Jack AU - Shumay, Elena AU - Telang, Frank AU - Thanos, Peter K AU - Alexoff, David AD - National Institute on Drug Abuse, Bethesda, Maryland, United States of America Y1 - 2010/12/07/ PY - 2010 DA - 2010 Dec 07 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - 2 KW - Toxicology Abstracts KW - Bioavailability KW - Methamphetamine KW - Mycobacterium KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968159708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Distribution+and+Pharmacokinetics+of+Methamphetamine+in+the+Human+Body%3A+Clinical+Implications&rft.au=Volkow%2C+Nora+D%3BFowler%2C+Joanna+S%3BWang%2C+Gene-Jack%3BShumay%2C+Elena%3BTelang%2C+Frank%3BThanos%2C+Peter+K%3BAlexoff%2C+David&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2010-12-07&rft.volume=5&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0015269 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2014-03-24 N1 - SubjectsTermNotLitGenreText - Methamphetamine; Mycobacterium DO - http://dx.doi.org/10.1371/journal.pone.0015269 ER - TY - JOUR T1 - High-throughput automated image analysis of neuroinflammation and neurodegeneration enables quantitative assessment of virus neurovirulence AN - 869570808; 14443603 AB - Historically, the safety of live attenuated vaccine candidates against neurotropic viruses was assessed by semi-quantitative analysis of virus-induced histopathology in the central nervous system of monkeys. We have developed a high-throughput automated image analysis (AIA) for the quantitative assessment of virus-induced neuroinflammation and neurodegeneration. Evaluation of the results generated by AIA showed that quantitative estimates of lymphocytic infiltration, microglial activation, and neurodegeneration strongly and significantly correlated with results of traditional histopathological scoring. In addition, we show that AIA is a targeted, objective, accurate, and time-efficient approach that provides reliable differentiation of virus neurovirulence. As such, it may become a useful tool in establishing consistent analytical standards across research and development laboratories and regulatory agencies, and may improve the safety evaluation of live virus vaccines. The implementation of this high-throughput AIA will markedly advance many fields of research including virology, neuroinflammation, neuroscience, and vaccinology. JF - Vaccine AU - Maximova, Olga A AU - Murphy, Brian R AU - Pletnev, Alexander G AD - Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, United States Y1 - 2010/12/06/ PY - 2010 DA - 2010 Dec 06 SP - 8315 EP - 8326 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 28 IS - 52 SN - 0264-410X, 0264-410X KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Cell activation KW - Central nervous system KW - Differentiation KW - Image processing KW - Inflammation KW - Nervous system KW - Neurodegeneration KW - Neurovirulence KW - Vaccines KW - V 22350:Immunology KW - F 06900:Methods KW - W 30915:Pharmaceuticals & Vaccines KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869570808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=High-throughput+automated+image+analysis+of+neuroinflammation+and+neurodegeneration+enables+quantitative+assessment+of+virus+neurovirulence&rft.au=Maximova%2C+Olga+A%3BMurphy%2C+Brian+R%3BPletnev%2C+Alexander+G&rft.aulast=Maximova&rft.aufirst=Olga&rft.date=2010-12-06&rft.volume=28&rft.issue=52&rft.spage=8315&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2010.07.070 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Differentiation; Central nervous system; Nervous system; Neurovirulence; Image processing; Vaccines; Neurodegeneration; Cell activation; Inflammation DO - http://dx.doi.org/10.1016/j.vaccine.2010.07.070 ER - TY - JOUR T1 - Decreased Level of Nurr1 in Heterozygous Young Adult Mice Leads to Exacerbated Acute and Long-Term Toxicity after Repeated Methamphetamine Exposure AN - 954607161; 14161713 AB - The abuse of psychostimulants, such as methamphetamine (METH), is prevalent in young adults and could lead to long-term adaptations in the midbrain dopamine system in abstinent human METH abusers. Nurr1 is a gene that is critical for the survival and maintenance of dopaminergic neurons and has been implicated in dopaminergic neuron related disorders. In this study, we examined the synergistic effects of repeated early exposure to methamphetamine in adolescence and reduction in Nurr1 gene levels. METH binge exposure in adolescence led to greater damage in the nigrostrial dopaminergic system when mice were exposed to METH binge later in life, suggesting a long-term adverse effect on the dopaminergic system. Compared to naieve mice that received METH binge treatment for the first time, mice pretreated with METH in adolescence showed a greater loss of tyrosine hydroxylase (TH) immunoreactivity in striatum, loss of THir fibers in the substantia nigra reticulata (SNr) as well as decreased dopamine transporter (DAT) level and compromised DA clearance in striatum. These effects were further exacerbated in Nurr1 heterozygous mice. Our data suggest that a prolonged adverse effect exists following adolescent METH binge exposure which may lead to greater damage to the dopaminergic system when exposed to repeated METH later in life. Furthermore, our data support that Nurr1 mutations or deficiency could be a potential genetic predisposition which may lead to higher vulnerability in some individuals. JF - PLoS ONE AU - Luo, Yu AU - Wang, Yun AU - Kuang, Serena Y AU - Chiang, Yung-Hsiao AU - Hoffer, Barry AD - National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland, United States of America Y1 - 2010/12/03/ PY - 2010 DA - 2010 Dec 03 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - 2 KW - Toxicology Abstracts KW - Adaptations KW - Nuclear receptors KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954607161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Decreased+Level+of+Nurr1+in+Heterozygous+Young+Adult+Mice+Leads+to+Exacerbated+Acute+and+Long-Term+Toxicity+after+Repeated+Methamphetamine+Exposure&rft.au=Luo%2C+Yu%3BWang%2C+Yun%3BKuang%2C+Serena+Y%3BChiang%2C+Yung-Hsiao%3BHoffer%2C+Barry&rft.aulast=Luo&rft.aufirst=Yu&rft.date=2010-12-03&rft.volume=5&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0015193 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-03-24 N1 - SubjectsTermNotLitGenreText - Nuclear receptors DO - http://dx.doi.org/10.1371/journal.pone.0015193 ER - TY - JOUR T1 - Blocking O-linked GlcNAc cycling in Drosophila insulin-producing cells perturbs glucose-insulin homeostasis. AN - 815547645; 20926386 AB - A dynamic cycle of O-linked GlcNAc (O-GlcNAc) addition and removal is catalyzed by O-GlcNAc transferase and O-GlcNAcase, respectively, in a process that serves as the final step in a nutrient-driven "hexosamine-signaling pathway." Evidence points to a role for O-GlcNAc cycling in diabetes and insulin resistance. We have used Drosophila melanogaster to determine whether O-GlcNAc metabolism plays a role in modulating Drosophila insulin-like peptide (dilp) production and insulin signaling. We employed transgenesis to either overexpress or knock down Drosophila Ogt(sxc) and Oga in insulin-producing cells (IPCs) or fat bodies using the GAL4-UAS system. Knockdown of Ogt decreased Dilp2, Dilp3, and Dilp5 production, with reduced body size and decreased phosphorylation of Akt in vivo. In contrast, knockdown of Oga increased Dilp2, Dilp3, and Dilp5 production, increased body size, and enhanced phosphorylation of Akt in vivo. However, knockdown of either Ogt(sxc) or Oga in the IPCs increased the hemolymph carbohydrate concentration. Furthermore, phosphorylation of Akt stimulated by extraneous insulin in an ex vivo cultured fat body of third instar larvae was diminished in strains subjected to IPC knockdown of Ogt or Oga. Knockdown of O-GlcNAc cycling enzymes in the fat body dramatically reduced neutral lipid stores. These results demonstrate that altered O-GlcNAc cycling in Drosophila IPCs modulates insulin production and influences the insulin responsiveness of peripheral tissues. The observed phenotypes in O-GlcNAc cycling mimic pancreatic β-cell dysfunction and glucose toxicity related to sustained hyperglycemia in mammals. JF - The Journal of biological chemistry AU - Sekine, Osamu AU - Love, Dona C AU - Rubenstein, David S AU - Hanover, John A AD - Laboratory of Cell Biochemistry and Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2010/12/03/ PY - 2010 DA - 2010 Dec 03 SP - 38684 EP - 38691 VL - 285 IS - 49 KW - Insulin KW - 0 KW - Glucose KW - IY9XDZ35W2 KW - Acetylglucosamine KW - V956696549 KW - Index Medicus KW - Animals KW - Gene Knockdown Techniques KW - Drosophila melanogaster KW - Glucose -- genetics KW - Glucose -- metabolism KW - Acetylglucosamine -- metabolism KW - Homeostasis -- physiology KW - Acetylglucosamine -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815547645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Blocking+O-linked+GlcNAc+cycling+in+Drosophila+insulin-producing+cells+perturbs+glucose-insulin+homeostasis.&rft.au=Sekine%2C+Osamu%3BLove%2C+Dona+C%3BRubenstein%2C+David+S%3BHanover%2C+John+A&rft.aulast=Sekine&rft.aufirst=Osamu&rft.date=2010-12-03&rft.volume=285&rft.issue=49&rft.spage=38684&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M110.155192 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-30 N1 - Date created - 2010-11-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10695-9 [12136128] J Biol Chem. 1997 Apr 4;272(14):9308-15 [9083067] Biochem Biophys Res Commun. 2000 Jan 7;267(1):26-32 [10623569] Proc Natl Acad Sci U S A. 2000 May 23;97(11):5735-9 [10801981] Diabetologia. 2000 Jul;43(7):821-35 [10952453] Diabetes. 2000 Sep;49(9):1492-9 [10969833] Curr Biol. 2001 Feb 20;11(4):213-21 [11250149] Science. 2001 Mar 23;291(5512):2376-8 [11269319] Biochem Biophys Res Commun. 2001 May 11;283(3):634-40 [11341771] Cell Tissue Res. 2001 May;304(2):317-21 [11396725] FASEB J. 2001 Sep;15(11):1865-76 [11532966] Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5313-8 [11959983] Genetics. 2002 Jul;161(3):1279-91 [12136030] Curr Biol. 2002 Aug 6;12(15):1293-300 [12176357] Science. 2003 Feb 28;299(5611):1346-51 [12610294] J Biol Chem. 2003 May 2;278(18):15641-51 [12594228] Biochem J. 2003 Sep 1;374(Pt 2):297-306 [12841848] Mol Cell Biol. 2004 Feb;24(4):1680-90 [14749383] Science. 2004 Jul 16;305(5682):361 [15192154] Nat Struct Mol Biol. 2004 Oct;11(10):1001-7 [15361863] J Biol Chem. 1997 Apr 4;272(14):9316-24 [9083068] J Clin Invest. 1998 Jan 1;101(1):202-11 [9421483] J Clin Invest. 1998 Jun 1;101(11):2377-86 [9616209] Hum Mol Genet. 1998 Nov;7(12):1859-72 [9811929] Arch Biochem Biophys. 1999 Feb 1;362(1):38-45 [9917327] J Biol Chem. 1999 May 14;274(20):14306-14 [10318852] J Biol Chem. 2004 Dec 17;279(51):53665-73 [15485860] Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):3105-10 [15708981] Diabetes. 2005 Apr;54(4):1214-21 [15793264] Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11266-71 [16051707] J Biol Chem. 2005 Sep 23;280(38):32944-56 [16027160] Sci STKE. 2005 Nov 29;2005(312):re13 [16317114] J Biol Chem. 2006 Feb 17;281(7):3918-25 [16356930] Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11952-7 [16882729] J Biol Chem. 2007 May 25;282(21):15589-96 [17403669] Science. 2009 Jul 3;325(5936):93-6 [19478141] Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13427-32 [19666537] Cell Metab. 2009 Sep;10(3):199-207 [19723496] Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19617-22 [19887630] Biochem J. 2010 Jan 1;425(1):13-26 [20001959] Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7413-8 [20368426] Science. 2002 May 10;296(5570):1118-20 [12004130] Cell. 1989 Apr 21;57(2):243-51 [2495182] Diabetes Care. 1990 Jun;13(6):610-30 [2192847] Diabetologia. 1994 Oct;37(10):1025-35 [7851681] Genes Dev. 1999 Dec 15;13(24):3244-58 [10617573] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M110.155192 ER - TY - JOUR T1 - Radiation-Induced Bystander Effects in Cultured Human Stem Cells AN - 954615746; 14161649 AB - The radiation-induced "bystander effect" (RIBE) was shown to occur in a number of experimental systems both in vitro and in vivo as a result of exposure to ionizing radiation (IR). RIBE manifests itself by intercellular communication from irradiated cells to non-irradiated cells which may cause DNA damage and eventual death in these bystander cells. It is known that human stem cells (hSC) are ultimately involved in numerous crucial biological processes such as embryologic development; maintenance of normal homeostasis; aging; and aging-related pathologies such as cancerogenesis and other diseases. However, very little is known about radiation-induced bystander effect in hSC. To mechanistically interrogate RIBE responses and to gain novel insights into RIBE specifically in hSC compartment, both medium transfer and cell co-culture bystander protocols were employed. Human bone-marrow mesenchymal stem cells (hMSC) and embryonic stem cells (hESC) were irradiated with doses 0.2 Gy, 2 Gy and 10 Gy of X-rays, allowed to recover either for 1 hr or 24 hr. Then conditioned medium was collected and transferred to non-irradiated hSC for time course studies. In addition, irradiated hMSC were labeled with a vital CMRA dye and co-cultured with non-irradiated bystander hMSC. The medium transfer data showed no evidence for RIBE either in hMSC and hESC by the criteria of induction of DNA damage and for apoptotic cell death compared to non-irradiated cells (p>0.05). A lack of robust RIBE was also demonstrated in hMSC co-cultured with irradiated cells (p>0.05). These data indicate that hSC might not be susceptible to damaging effects of RIBE signaling compared to differentiated adult human somatic cells as shown previously. This finding could have profound implications in a field of radiation biology/oncology, in evaluating radiation risk of IR exposures, and for the safety and efficacy of hSC regenerative-based therapies. JF - PLoS ONE AU - Sokolov, Mykyta V AU - Neumann, Ronald D AD - Nuclear Medicine Division, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2010/12/02/ PY - 2010 DA - 2010 Dec 02 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - 2 KW - Biotechnology and Bioengineering Abstracts KW - I.R. radiation KW - Data processing KW - Apoptosis KW - Aging KW - Bone marrow KW - Oncology KW - Homeostasis KW - Somatic cells KW - Ribes KW - DNA damage KW - Cell death KW - Stem cells KW - Embryo cells KW - Ionizing radiation KW - Mesenchyme KW - Intercellular signalling KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954615746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Radiation-Induced+Bystander+Effects+in+Cultured+Human+Stem+Cells&rft.au=Sokolov%2C+Mykyta+V%3BNeumann%2C+Ronald+D&rft.aulast=Sokolov&rft.aufirst=Mykyta&rft.date=2010-12-02&rft.volume=5&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0014195 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-07-24 N1 - SubjectsTermNotLitGenreText - Apoptosis; Data processing; I.R. radiation; Aging; Bone marrow; Oncology; Homeostasis; Somatic cells; DNA damage; Stem cells; Cell death; Embryo cells; Ionizing radiation; Mesenchyme; Intercellular signalling; Ribes DO - http://dx.doi.org/10.1371/journal.pone.0014195 ER - TY - JOUR T1 - Multiple indicators of ambient and personal ultraviolet radiation exposure and risk of non-Hodgkin lymphoma (United States) AN - 817604585; 13876812 AB - Recent epidemiologic studies have suggested that ultraviolet radiation (UV) may protect against non-Hodgkin lymphoma (NHL), but few, if any, have assessed multiple indicators of ambient and personal UV exposure. Using the US Radiologic Technologists study, we examined the association between NHL and self-reported time outdoors in summer, as well as average year-round and seasonal ambient exposures based on satellite estimates for different age periods, and sun susceptibility in participants who had responded to two questionnaires (1994-1998, 2003-2005) and who were cancer-free as of the earlier questionnaire. Using unconditional logistic regression, we estimated the odds ratio (OR) and 95% confidence intervals for 64,103 participants with 137 NHL cases. Self-reported time outdoors in summer was unrelated to risk. Lower risk was somewhat related to higher average year-round and winter ambient exposure for the period closest in time, and prior to, diagnosis (ages 20-39). Relative to 1.0 for the lowest quartile of average year-round ambient UV, the estimated OR for successively higher quartiles was 0.68 (0.42-1.10); 0.82 (0.52-1.29); and 0.64 (0.40-1.03), p-trend = 0.06), for this age period. The lower NHL risk associated with higher year-round average and winter ambient UV provides modest additional support for a protective relationship between UV and NHL. JF - Journal of Photochemistry and Photobiology B: Biology AU - Freedman, DMichal AU - Kimlin, Michael G AU - Hoffbeck, Richard W AU - Alexander, Bruce H AU - Linet, Martha S AD - National Cancer Institute, Division of Cancer Epidemiology and Genetics, NIH, DHHS, Bethesda, MD, USA Y1 - 2010/12/02/ PY - 2010 DA - 2010 Dec 02 SP - 321 EP - 325 PB - Elesevier Sequoia S.A. VL - 101 IS - 3 SN - 1011-1344, 1011-1344 KW - Toxicology Abstracts KW - Age KW - X:24390 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/817604585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Photochemistry+and+Photobiology+B%3A+Biology&rft.atitle=Multiple+indicators+of+ambient+and+personal+ultraviolet+radiation+exposure+and+risk+of+non-Hodgkin+lymphoma+%28United+States%29&rft.au=Freedman%2C+DMichal%3BKimlin%2C+Michael+G%3BHoffbeck%2C+Richard+W%3BAlexander%2C+Bruce+H%3BLinet%2C+Martha+S&rft.aulast=Freedman&rft.aufirst=DMichal&rft.date=2010-12-02&rft.volume=101&rft.issue=3&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Journal+of+Photochemistry+and+Photobiology+B%3A+Biology&rft.issn=10111344&rft_id=info:doi/10.1016%2Fj.jphotobiol.2010.08.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-12-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Age DO - http://dx.doi.org/10.1016/j.jphotobiol.2010.08.001 ER - TY - JOUR T1 - Comparison of women's breast cancer risk factors in Geneva, Switzerland and Shanghai, China AN - 954615887; 14182829 AB - We compared the prevalence of known and suspected breast cancer risk factors among women in Geneva, Switzerland, where the annual incidence of breast cancer is high, to women in Shanghai, China, where incidence is lower. Methods: Different translations of the same woman's health questionnaire were administered to women aged 35 to 74 years in Shanghai (n = 631) and Geneva (n = 1,212) during 1996-1997 and reproductive and lifestyle factors compared. Results: Shanghai women reported older age at menarche (median 15 vs. 13 years), fewer nulliparity (7.3 vs. 21.6%), younger age at first live birth (median 25.7 vs. 28.4 years), and shorter duration of reproductive life (median 35.7 vs. 38.4 years). Geneva women had a greater prevalence of current cigarette smoking (22.4 vs. 1.8%), oral contraceptive use (61.1 vs. 10.0%), hormone replacement therapy use (23.4 vs. 0.8%), and family history of breast cancer (8.6 vs. 1.4%). Among women who breastfed, Shanghai women had more than twice the duration of breastfeeding than Geneva women (median 48 vs. 21 weeks). Conclusions: Differences in the prevalence of breast cancer risk factors, in particular reproductive characteristics, may contribute to the large contrast in cumulative risk between women living in Geneva and Shanghai. JF - Preventive Medicine AU - DeRoo, Lisa A AU - Vlastos, Anne Therese AU - Mock, Pascal AU - Vlastos, Georges AU - Morabia, Alfredo AD - Division of Clinical Epidemiology, Department of Community Medicine, Geneva University Hospitals, Geneva, Switzerland, DeRooL@niehs.nih.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 497 EP - 501 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 51 IS - 6 SN - 0091-7435, 0091-7435 KW - Risk Abstracts; Health & Safety Science Abstracts KW - breast feeding KW - Age KW - Cigarettes KW - Switzerland KW - Cancer KW - contraceptives KW - Genetics KW - Breast cancer KW - Switzerland, Geneva KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - Females KW - hormone replacement therapy KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954615887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventive+Medicine&rft.atitle=Comparison+of+women%27s+breast+cancer+risk+factors+in+Geneva%2C+Switzerland+and+Shanghai%2C+China&rft.au=DeRoo%2C+Lisa+A%3BVlastos%2C+Anne+Therese%3BMock%2C+Pascal%3BVlastos%2C+Georges%3BMorabia%2C+Alfredo&rft.aulast=DeRoo&rft.aufirst=Lisa&rft.date=2010-12-01&rft.volume=51&rft.issue=6&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=Preventive+Medicine&rft.issn=00917435&rft_id=info:doi/10.1016%2Fj.ypmed.2010.09.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - breast feeding; Genetics; Age; Cigarettes; Breast cancer; Females; hormone replacement therapy; Cancer; contraceptives; Switzerland, Geneva; China, People's Rep., Shanghai; China, People's Rep.; Switzerland DO - http://dx.doi.org/10.1016/j.ypmed.2010.09.013 ER - TY - JOUR T1 - Douglass C. North, John Joseph Wallis, and Barry R. Weingast: Violence and Social Orders: A Conceptual Framework for Interpreting Recorded Human History AN - 954612561; 14196603 JF - Population And Development Review AU - Haaga, John G AD - National Institute on Aging Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 841 EP - 843 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 36 IS - 4 SN - 0098-7921, 0098-7921 KW - Environment Abstracts; Sustainability Science Abstracts KW - Historical account KW - Reviews KW - Violence KW - ENA 13:Population Planning & Control KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954612561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Population+And+Development+Review&rft.atitle=Douglass+C.+North%2C+John+Joseph+Wallis%2C+and+Barry+R.+Weingast%3A+Violence+and+Social+Orders%3A+A+Conceptual+Framework+for+Interpreting+Recorded+Human+History&rft.au=Haaga%2C+John+G&rft.aulast=Haaga&rft.aufirst=John&rft.date=2010-12-01&rft.volume=36&rft.issue=4&rft.spage=841&rft.isbn=&rft.btitle=&rft.title=Population+And+Development+Review&rft.issn=00987921&rft_id=info:doi/10.1111%2Fj.1728-4457.2010.00360.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Number of references - 3 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Historical account; Reviews; Violence DO - http://dx.doi.org/10.1111/j.1728-4457.2010.00360.x ER - TY - JOUR T1 - Late Health Effects of Ionizing Radiation: Bridging the Experimental and Epidemiologic Divide AN - 954591344; 14037678 JF - Radiation Research AU - Ron, Elaine AU - Jacob, Peter AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 789 EP - 792 PB - Radiation Research Society VL - 174 IS - 6b SN - 0033-7587, 0033-7587 KW - Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954591344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Late+Health+Effects+of+Ionizing+Radiation%3A+Bridging+the+Experimental+and+Epidemiologic+Divide&rft.au=Ron%2C+Elaine%3BJacob%2C+Peter&rft.aulast=Ron&rft.aufirst=Elaine&rft.date=2010-12-01&rft.volume=174&rft.issue=6b&rft.spage=789&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRRXX24.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 DO - http://dx.doi.org/10.1667/RRXX24.1 ER - TY - JOUR T1 - Prenatal methadone exposure, meconium biomarker - concentrations and neonatal abstinence syndrome AN - 920063522; 4266260 AB - Methadone is standard pharmacotherapy for opioid-dependent pregnant women, yet the relationship between maternal methadone dose and neonatal abstinence syndrome (NAS) severity is still unclear. This research evaluated whether quantification of fetal methadone and drug exposure via meconium would reflect maternal dose and predict neonatal outcomes. Design: facility treating pregnant and post-partum women and their children. Participants: women received 30-110 mg methadone daily. Measurements: Maternal methadone dose, infant birth parameters and NAS assessments were extracted from medical records. Thrice-weekly urine specimens were screened for opioids and cocaine. Newborn meconium specimens were quantified for methadone, opioid, cocaine and tobacco biomarkers. Findings: methadone concentrations, presence of opioids, cocaine and/or tobacco in meconium, maternal methadone dose or NAS severity. Opioid and cocaine were also found in 36.7 and 38.8 of meconium specimens, respectively, and were associated with positive urine specimens in the third trimester. The presence of opioids other than methadone in meconium correlated with increased rates of preterm birth, longer infant hospital stays and decreased maternal time in drug treatment. Conclusions: Methadone and its metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) concentrations in meconium did not predict infant birth parameters or NAS severity. Prospective urine testing defined meconium drug detection windows for opiates and cocaine as 3 months, rather than the currently accepted 6 months. The presence of opioids in meconium could be used as a biomarker for infants at elevated risk in the newborn period. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Jansson, Lauren M AU - Jones, Hendree E AU - Huestis, Marilyn A AU - Gray, Teresa R AU - Choo, Robin E AU - Concheiro, Marta AU - Williams, Erica AU - Elko, Andrea AD - National Institutes of Health, Baltimore ; University of Pittsburgh ; Johns Hopkins University Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 2151 EP - 2159 VL - 105 IS - 12 SN - 0965-2140, 0965-2140 KW - Sociology KW - Risk KW - Opiates KW - Tobacco KW - Addiction KW - Drug addiction KW - Cocaine KW - Drugs KW - Infants KW - Pregnancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920063522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Prenatal+methadone+exposure%2C+meconium+biomarker+-+concentrations+and+neonatal+abstinence+syndrome&rft.au=Jansson%2C+Lauren+M%3BJones%2C+Hendree+E%3BHuestis%2C+Marilyn+A%3BGray%2C+Teresa+R%3BChoo%2C+Robin+E%3BConcheiro%2C+Marta%3BWilliams%2C+Erica%3BElko%2C+Andrea&rft.aulast=Jansson&rft.aufirst=Lauren&rft.date=2010-12-01&rft.volume=105&rft.issue=12&rft.spage=2151&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2010.03097.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 2435 3755; 10020; 8953 3755; 561 6220; 3744 561 6220; 3755; 6495 2212; 11035; 12766 3055 798 10286 DO - http://dx.doi.org/10.1111/j.1360-0443.2010.03097.x ER - TY - JOUR T1 - Nicotine dependence and quitting behaviors among menthol and non-menthol smokers with similar consumptive patterns AN - 920063508; 4266243 AB - This study examines the associations between usual cigarette brand (i.e. menthol, non-menthol) and markers for nicotine dependence and quitting behaviors. Design: 2006/07 Tobacco Use Supplements to the Current Population Surveys were pooled to conduct secondary data analysis. Setting: National data were collected using in-person and telephone computer-assisted interviews by the United States Census Bureau among civilian, non-institutionalized people aged 15 years and older. Participants: 46 273. Measurements: The associations between usual cigarette brand and time to first cigarette within 5 and 30 minutes after waking, quit attempts in the past 12 months and length of smoking abstinence in the past 12 months were examined. Bivariate and multivariate logistic regression models were stratified by smoking intensity: 5, 6-10, 11-19 and 20+ cigarettes per day. Findings: cigarettes per day among non-menthol smokers (P 2 weeks in the past 12 months. Conclusions: Findings: from this national survey of daily smokers demonstrate that menthol smokers in the United States who report consuming 6-10 cigarettes per day show greater signs of nicotine dependence than comparable non-menthol smokers. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Gibson, James Todd AU - Fagan, Pebbles AU - Moolchan, Eric T AU - Hart, Alton AU - Rose, Allison AU - Lawrence, Deirdre AU - Shavers, Vickie L AD - National Cancer Institute ; Alkermes, Cambridge ; Virginia Commonwealth University ; Information Management Systems Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 55 EP - 74 VL - 105 IS - 12 SN - 0965-2140, 0965-2140 KW - Sociology KW - Smoking KW - Behavioural psychology KW - Regression analysis KW - Tobacco KW - Surveys KW - Addiction KW - U.S.A. KW - Brands KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920063508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Nicotine+dependence+and+quitting+behaviors+among+menthol+and+non-menthol+smokers+with+similar+consumptive+patterns&rft.au=Gibson%2C+James+Todd%3BFagan%2C+Pebbles%3BMoolchan%2C+Eric+T%3BHart%2C+Alton%3BRose%2C+Allison%3BLawrence%2C+Deirdre%3BShavers%2C+Vickie+L&rft.aulast=Gibson&rft.aufirst=James&rft.date=2010-12-01&rft.volume=105&rft.issue=12&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2010.03190.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12766 3055 798 10286; 11755 5707 6071 1542 11325; 10739 12228 10919; 8163; 561 6220; 1757 7738 11245 11239; 12429; 1540 1543 10404; 433 293 14 DO - http://dx.doi.org/10.1111/j.1360-0443.2010.03190.x ER - TY - JOUR T1 - National patterns and correlates of mentholated cigarette use in the United States AN - 920063458; 4266239 AB - Aim: To examine the patterns and correlates of mentholated cigarette smoking among adult smokers in the United States. Design: pooled from the 2003 and 2006/07 Tobacco Use Supplements to the Current Population Survey. Measurements: The associations between socio-demographic and smoking variables were examined with gender- and race/ethnicity-stratified multivariate logistic regression models predicting current use of mentholated cigarettes. Findings: black smokers were 10-11 times more likely to smoke mentholated cigarettes than white smokers men: odds ratio (OR): 11.59, 99% confidence interval (CI): 9.79-13.72; women: OR: 10.12, 99% CI: 8.45-12.11). With the exception of American Indian/Aleut/Eskimo smokers, non-white smokers were significantly more likely to smoke mentholated cigarettes than were white smokers. Additional significant factors associated with mentholated cigarette smoking included being unmarried (never married: OR: 1.21, 99% CI: 1.09-1.34; divorced/separated: OR: 1.13, 99% CI: 1.03-1.23), being born in a US territory (OR: 2.01, 99% CI: 1.35-3.01), living in a non-metropolitan area (OR: 0.87, 99% CI: 0.80-0.96), being unemployed (OR: 1.24, 99% CI: 1.06-1.44) and lower levels of education. Race/ethnicity-stratified analyses showed that women were more likely than men to smoke mentholated cigarettes. Among black smokers, young adults (aged 18-24 years) were four times more likely to smoke mentholated cigarettes compared with individuals aged 65+. Conclusions: Race/ethnicity, gender and age are significant correlates of mentholated cigarette smoking among current smokers. Given the importance of menthol in the cigarette market and the potential untoward health effects of this additive, continued surveillance of the prevalence and correlates of mentholated cigarette use among diverse socio-demographic groups is warranted to inform appropriate interventions. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Gibson, James Todd AU - Backinger, Cathy L AU - Lawrence, Deirdre AU - Rose, Allison AU - Fagan, Pebbles AU - Moolchan, Eric T AD - National Cancer Institute, Bethesda ; Alkermes, Cambridge ; Information Management Systems, Silver Spring Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 13 EP - 31 VL - 105 IS - 12 SN - 0965-2140, 0965-2140 KW - Sociology KW - Smoking KW - Epidemiology KW - Gender KW - Race KW - Tobacco KW - Surveys KW - Adults KW - U.S.A. KW - Ethnic groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920063458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=National+patterns+and+correlates+of+mentholated+cigarette+use+in+the+United+States&rft.au=Gibson%2C+James+Todd%3BBackinger%2C+Cathy+L%3BLawrence%2C+Deirdre%3BRose%2C+Allison%3BFagan%2C+Pebbles%3BMoolchan%2C+Eric+T&rft.aulast=Gibson&rft.aufirst=James&rft.date=2010-12-01&rft.volume=105&rft.issue=12&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2010.03203.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12766 3055 798 10286; 5421 6091; 10555 6091; 4357 7894; 4424; 603; 11755 5707 6071 1542 11325; 12429; 433 293 14 DO - http://dx.doi.org/10.1111/j.1360-0443.2010.03203.x ER - TY - JOUR T1 - Research integrity in China: problems and prospects AN - 911918143; 4256241 AB - In little more than thirty years, China has recovered from the intellectual stagnation brought about by the Cultural Revolution to become a global leader in science and technology. Like other leading countries in science and technology, China has encountered some ethical problems related to the conduct of research. China's leaders have taken some steps to respond to these problems, such as developing ethics policies and establishing oversight committees. To keep moving forward, China needs to continue to take effective action to promote research integrity. Some of the challenges China faces include additional policy development, promoting education in responsible conduct of research, protecting whistle-blowers, and cultivating an ethical research environment. Reprinted by permission of Blackwell Publishers JF - Developing world bioethics AU - Zeng, Weiqin AU - Resnik, David AD - National Institute of Environmental Health Sciences ; Xiamen University Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 164 EP - 171 VL - 10 IS - 3 SN - 1471-8731, 1471-8731 KW - Anthropology KW - Plagiarism KW - Education KW - Research methods KW - Fraud KW - Cultural Revolution KW - Ethics KW - Bioethics KW - Government policy KW - Science and technology KW - China UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911918143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developing+world+bioethics&rft.atitle=Research+integrity+in+China%3A+problems+and+prospects&rft.au=Zeng%2C+Weiqin%3BResnik%2C+David&rft.aulast=Zeng&rft.aufirst=Weiqin&rft.date=2010-12-01&rft.volume=10&rft.issue=3&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Developing+world+bioethics&rft.issn=14718731&rft_id=info:doi/10.1111%2Fj.1471-8847.2009.00263.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4408 8282 8281 6085; 5270 3035 3015 11881 2909; 5574 10472; 4049; 1603 4408 8282 8281 6085; 10919; 3086 11002; 11326 11325 12622; 93 116 30 DO - http://dx.doi.org/10.1111/j.1471-8847.2009.00263.x ER - TY - JOUR T1 - Is Slow-Onset Long-Acting Monoamine Transport Blockade to Cocaine as Methadone is to Heroin? Implication for Anti-Addiction Medications AN - 907151498; 14165488 AB - The success of methadone in treating opiate addiction has suggested that long-acting agonist therapies may be similarly useful for treating cocaine addiction. Here, we examined this hypothesis, using the slow-onset long-acting monoamine reuptake inhibitor 31,345, a trans-aminotetralin analog, in a variety of addiction-related animal models, and compared it with methadone's effects on heroin's actions in the same animal models. Systemic administration of 31,345 produced long-lasting enhancement of electrical brain-stimulation reward (BSR) and extracellular nucleus accumbens (NAc) dopamine (DA). Pretreatment with 31,345 augmented cocaine-enhanced BSR, prolonged cocaine-enhanced NAc DA, and produced a long-term (24-48h) reduction in cocaine self-administration rate without obvious extinction pattern, suggesting an additive effect of 31,345 with cocaine. In contrast, methadone pretreatment not only dose-dependently inhibited heroin self-administration with an extinction pattern but also dose-dependently inhibited heroin-enhanced BSR and NAc DA, suggesting functional antagonism by methadone of heroin's actions. In addition, 31,345 appears to possess significant abuse liability, as it produces dose-dependent enhancement of BSR and NAc DA, maintains a low rate of self-administration behavior, and dose-dependently reinstates drug-seeking behavior. In contrast, methadone only partially maintains self-administration with an extinction pattern, and fails to induce reinstatement of drug-seeking behavior. These findings suggest that 31,345 is a cocaine-like slow-onset long-acting monoamine transporter inhibitor that may act as an agonist therapy for cocaine addiction. However, its pattern of action appears to be significantly different from that of methadone. Ideal agonist substitutes for cocaine should fully emulate methadone's actions, that is, functionally antagonizing cocaine's action while blocking monoamine transporters to augment synaptic DA. JF - Neuropsychopharmacology AU - Peng, Xiao-Qing AU - Xi, Zheng-Xiong AU - Li, Xia AU - Spiller, Krista AU - Li, Jie AU - Chun, Lauren AU - Wu, Kuo-Ming AU - Froimowitz, Mark AU - Gardner, Eliot L AD - Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD, USA Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 2564 EP - 2578 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 35 IS - 13 SN - 0893-133X, 0893-133X KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Nucleus accumbens KW - Opiates KW - Extinction KW - Heroin KW - Monoamine transporter KW - Animal models KW - Antagonism KW - Reinstatement KW - Methadone KW - Dopamine KW - Reinforcement KW - Addiction KW - Drug addiction KW - Cocaine KW - Drug self-administration KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907151498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology&rft.atitle=Is+Slow-Onset+Long-Acting+Monoamine+Transport+Blockade+to+Cocaine+as+Methadone+is+to+Heroin%3F+Implication+for+Anti-Addiction+Medications&rft.au=Peng%2C+Xiao-Qing%3BXi%2C+Zheng-Xiong%3BLi%2C+Xia%3BSpiller%2C+Krista%3BLi%2C+Jie%3BChun%2C+Lauren%3BWu%2C+Kuo-Ming%3BFroimowitz%2C+Mark%3BGardner%2C+Eliot+L&rft.aulast=Peng&rft.aufirst=Xiao-Qing&rft.date=2010-12-01&rft.volume=35&rft.issue=13&rft.spage=2564&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/10.1038%2Fnpp.2010.133 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-04-06 N1 - SubjectsTermNotLitGenreText - Nucleus accumbens; Opiates; Extinction; Heroin; Monoamine transporter; Animal models; Antagonism; Reinstatement; Methadone; Dopamine; Reinforcement; Addiction; Cocaine; Drug addiction; Drug self-administration DO - http://dx.doi.org/10.1038/npp.2010.133 ER - TY - JOUR T1 - The aetiology of upper aerodigestive tract cancers among young adults in Europe: the ARCAGE study AN - 899131995; 14089713 AB - Background: The incidence of cancers of the upper aerodigestive tract (UADT) is increasing throughout the world. To date the increases have been proportionally greatest among young people. Several reports have suggested that they often do not have a history of tobacco smoking or heavy alcohol consumption. Objective: To determine the contribution of lifestyle factors to the etiology of UADT cancers occurring in those aged less than 50years. Methods: A case-control study was conducted in 10 European countries. Cases were cancers of the oral cavity and pharynx, larynx and esophagus, and hospital or population controls were age and sex matched. Results: There were 356 cases younger than 50years and 419 controls. Risk was strongly related to current smoking [odds ratio (OR) 5.5 95%; confidence interval (CI) (3.3, 9.2)], and risk increased with number of pack-years smoked. Risk was also related to alcohol consumption for both current (OR 1.8; 0.97, 3.3) and past (OR 3.4; 1.6, 7.4) drinkers, and risk increased with number of drink-years. Persons frequently consuming fruits and vegetables were at significantly reduced risk. Conclusions: Risk factors already identified as being important for UADT cancers in adults are also important influences on risk in younger adults. The implication of these results is that the public health message in preventing UADT cancers remains the same to young and old alike. JF - Cancer Causes & Control AU - Macfarlane, Tatiana V AU - Macfarlane, Gary J AU - Oliver, Richard J AU - Benhamou, Simone AU - Bouchardy, Christine AU - Ahrens, Wolfgang AU - Pohlabeln, Hermann AU - Lagiou, Pagona AU - Lagiou, Areti AU - Castellsague, Xavier AU - Agudo, Antonio AU - Merletti, Franco AU - Richiardi, Lorenzo AU - Kjaerheim, Kristina AU - Slamova, Alena AU - Schejbalova, Miriam AU - Canova, Cristina AU - Simonato, Lorenzo AU - Talamini, Renato AU - Barzan, Luigi AU - Conway, David I AU - McKinney, Patricia A AU - Znaor, Ariana AU - Lowry, Raymond J AU - Thomson, Peter AU - Healy, Claire M AU - McCartan, Bernard E AU - Marron, Manuela AU - Hashibe, Mia AU - Brennan, Paul AD - Unit of Epidemiology and Biostatistics, National Cancer Institute, IRCCS, Aviano, Italy, Tatiana.Macfarlane@abdn.ac.uk Tatiana.Macfarlane@abdn.ac.uk Tatiana.Macfarlane@abdn.ac.uk Tatiana.Macfarlane@abdn.ac.uk Tatiana.Macfarlane@abdn.ac.uk Tatiana.Macfarlane@abdn.ac.uk Tatiana.Macfarlane@abdn.ac.uk Tatiana.Macfarlane@abdn.ac.uk Tatiana.Macfarlane@abdn.ac.uk Tatiana.Macfarlane@abdn.ac.uk Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 2213 EP - 2221 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 21 IS - 12 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Alcohol KW - fruits KW - Europe KW - young adults KW - Cancer KW - Public health KW - risk reduction KW - Tobacco KW - population control KW - Hospitals KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899131995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=The+aetiology+of+upper+aerodigestive+tract+cancers+among+young+adults+in+Europe%3A+the+ARCAGE+study&rft.au=Macfarlane%2C+Tatiana+V%3BMacfarlane%2C+Gary+J%3BOliver%2C+Richard+J%3BBenhamou%2C+Simone%3BBouchardy%2C+Christine%3BAhrens%2C+Wolfgang%3BPohlabeln%2C+Hermann%3BLagiou%2C+Pagona%3BLagiou%2C+Areti%3BCastellsague%2C+Xavier%3BAgudo%2C+Antonio%3BMerletti%2C+Franco%3BRichiardi%2C+Lorenzo%3BKjaerheim%2C+Kristina%3BSlamova%2C+Alena%3BSchejbalova%2C+Miriam%3BCanova%2C+Cristina%3BSimonato%2C+Lorenzo%3BTalamini%2C+Renato%3BBarzan%2C+Luigi%3BConway%2C+David+I%3BMcKinney%2C+Patricia+A%3BZnaor%2C+Ariana%3BLowry%2C+Raymond+J%3BThomson%2C+Peter%3BHealy%2C+Claire+M%3BMcCartan%2C+Bernard+E%3BMarron%2C+Manuela%3BHashibe%2C+Mia%3BBrennan%2C+Paul&rft.aulast=Macfarlane&rft.aufirst=Tatiana&rft.date=2010-12-01&rft.volume=21&rft.issue=12&rft.spage=2213&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-010-9641-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - risk reduction; Alcohol; fruits; Tobacco; young adults; population control; Cancer; Hospitals; Public health; Europe DO - http://dx.doi.org/10.1007/s10552-010-9641-3 ER - TY - JOUR T1 - Maternal and Congenital Brucellosis in Texas: Changing Travel Patterns and Laboratory Implications AN - 888095831; 14237817 AB - Brucellosis is an uncommon disease in the US, but Texas reports approximately a third of cases. We review the investigation of a pair of mother-infant cases that were unique in the demographics, the nature of travel exposure and the resulting brucellosis exposure in a hospital's delivery suite and laboratory. These cases illustrate the changing nature of travel and the need to obtain a relevant travel history and adequate laboratory procedures. Clinicians and laboratory workers in Texas need to understand that brucellosis remains an endemic disease, but that its epidemiology is changing. JF - Journal of Immigrant and Minority Health AU - Glocwicz, Janet AU - Stonecipher, Shelley AU - Schulte, Joann AD - Texas Department of State Health Services, Region 2/3, 1301 S. Bowen Rd. # 200, Arlington, TX, USA, schultej@niaid.nih.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 952 EP - 955 PB - Springer New York, LLC, 233 Spring St New York NY 10013-1578 USA VL - 12 IS - 6 SN - 1557-1912, 1557-1912 KW - Microbiology Abstracts B: Bacteriology KW - Travel KW - Demography KW - Workers KW - Epidemiology KW - Immigrants KW - Brucellosis KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888095831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immigrant+and+Minority+Health&rft.atitle=Maternal+and+Congenital+Brucellosis+in+Texas%3A+Changing+Travel+Patterns+and+Laboratory+Implications&rft.au=Glocwicz%2C+Janet%3BStonecipher%2C+Shelley%3BSchulte%2C+Joann&rft.aulast=Glocwicz&rft.aufirst=Janet&rft.date=2010-12-01&rft.volume=12&rft.issue=6&rft.spage=952&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immigrant+and+Minority+Health&rft.issn=15571912&rft_id=info:doi/10.1007%2Fs10903-009-9295-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Demography; Travel; Workers; Epidemiology; Immigrants; Brucellosis DO - http://dx.doi.org/10.1007/s10903-009-9295-y ER - TY - JOUR T1 - Efficient implementation of hardware-optimized gradient sequences for real-time imaging AN - 883039717; 15255453 AB - This work improves the performance of interactive real-time imaging with balanced steady-state free precession. The method employs hardware-optimized gradient pulses, together with a novel phase-encoding strategy that simplifies the design and implementation of the optimized gradient waveforms. In particular, the waveforms for intermediate phase-encode steps are obtained by simple linear combination, rather than separate optimized waveform calculations. Gradient waveforms are redesigned in real time as the scan plane is manipulated, and the resulting sequence operates at the specified limits of the MRI gradient subsystem for each new scan-plane orientation. The implementation provides 14-25% improvement in the sequence pulse repetition time over the vendor-supplied interactive real-time imaging sequence for similar scan parameters on our MRI scanner. Magn Reson Med, 2010. [copy 2010 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Derbyshire, J Andrew AU - Herzka, Daniel A AU - McVeigh, Elliot R AU - Lederman, Robert J AD - Translational Medicine Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA, jad11@nih.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1814 EP - 1820 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 64 IS - 6 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Repetition KW - Magnetic resonance imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883039717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Efficient+implementation+of+hardware-optimized+gradient+sequences+for+real-time+imaging&rft.au=Derbyshire%2C+J+Andrew%3BHerzka%2C+Daniel+A%3BMcVeigh%2C+Elliot+R%3BLederman%2C+Robert+J&rft.aulast=Derbyshire&rft.aufirst=J&rft.date=2010-12-01&rft.volume=64&rft.issue=6&rft.spage=1814&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22211 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22211/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Repetition; Magnetic resonance imaging DO - http://dx.doi.org/10.1002/mrm.22211 ER - TY - JOUR T1 - High-field continuous arterial spin labeling with long labeling duration: Reduced confounds from blood transit time and postlabeling delay AN - 883039397; 15255425 AB - In quantitative perfusion imaging using arterial spin labeling, variable blood transit times and postlabeling delays are two confounding factors that may compromise the accuracy of perfusion quantifications. In this study, theoretical analyses and experimental data at 9.4 T demonstrate that increasing labeling duration not only enhances the contrast of the arterial spin labeling signal but also minimizes the effect of variable postlabeling delays in multislice arterial spin labeling acquisitions. With a labeling duration of 6.4 sec, arterial spin labeling signal acquired in multislice mode (11 slices) is very similar to that acquired in single-slice mode. Previous studies have shown that inserting a delay between the spin labeling pulse and the image acquisition pulse could reduce confounds resulting from variable blood transit times at the expense of arterial spin labeling sensitivity. Our simulations suggest that enhancing the contrast of arterial spin labeling signal offers the opportunity for extending the postlabeling delay to a longer duration, minimizing systematic errors associated with a wide range of blood transit times, which could have significant implications for applying arterial spin labeling techniques to perfusion imaging of pathological conditions in animal models. Magn Reson Med, 2010. [copy 2010 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Lu, Hanbing AU - Leoni, Renata AU - Silva, Afonso C AU - Stein, Elliot A AU - Yang, Yihong AD - Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Programs, National Institutes of Health, Baltimore, Maryland, USA, luha@intra.nida.nih.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1557 EP - 1566 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 64 IS - 6 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Blood KW - Perfusion KW - Data processing KW - Animal models KW - N.M.R. KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883039397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=High-field+continuous+arterial+spin+labeling+with+long+labeling+duration%3A+Reduced+confounds+from+blood+transit+time+and+postlabeling+delay&rft.au=Lu%2C+Hanbing%3BLeoni%2C+Renata%3BSilva%2C+Afonso+C%3BStein%2C+Elliot+A%3BYang%2C+Yihong&rft.aulast=Lu&rft.aufirst=Hanbing&rft.date=2010-12-01&rft.volume=64&rft.issue=6&rft.spage=1557&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22576 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22576/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Blood; Data processing; Perfusion; Animal models; N.M.R.; imaging DO - http://dx.doi.org/10.1002/mrm.22576 ER - TY - JOUR T1 - Development of Human Anti-Murine T-Cell Receptor Antibodies in Both Responding and Nonresponding Patients Enrolled in TCR Gene Therapy Trials AN - 874179836; 14047791 AB - PURPOSE: Immune responses to gene-modified cells are a concern in the field of human gene therapy, as they may impede effective treatment. We conducted 2 clinical trials in which cancer patients were treated with lymphocytes genetically engineered to express murine T-cell receptors (mTCR) specific for tumor-associated antigens p53 and gp100. Experimental Design: Twenty-six patients treated with autologous lymphocytes expressing mTCR had blood and serum samples available for analysis. Patient sera were assayed for the development of a humoral immune response. Adoptive cell transfer characteristics were analyzed to identify correlates to immune response. RESULTS: Six of 26 (23%) patients' posttreatment sera exhibited specific binding of human anti-mTCR antibodies to lymphocytes transduced with the mTCR. Antibody development was found in both responding and nonresponding patients. The posttreatment sera of 3 of these 6 patients mediated a 60% to 99% inhibition of mTCR activity as measured by a reduction in antigen-specific interferon- gamma release. Detailed analysis of posttreatment serum revealed that antibody binding was beta -chain specific in 1 patient whereas it was alpha -chain specific in another. CONCLUSIONS: A subset of patients treated with mTCR-engineered T cells developed antibodies directed to the mTCR variable regions and not to the constant region domains common to all mTCR. Overall, the development of a host immune response was not associated with the level of transduced cell persistence or response to therapy. In summary, patients treated with mTCR can develop an immune response to gene-modified cells in a minority of cases, but this may not affect clinical outcome. Clin Cancer Res; 16(23); 5852-61. [copy ]2010 AACR. JF - Clinical Cancer Research AU - Davis, Jeremy L AU - Theoret, Marc R AU - Zheng, Zhili AU - Lamers, Cor HJ AU - Rosenberg, Steven A AU - Morgan, Richard A AD - Authors' Affiliations: Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Y1 - 2010/12/01/ PY - 2010 DA - 2010 Dec 01 SP - 5852 EP - 5861 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 16 IS - 23 SN - 1078-0432, 1078-0432 KW - Genetics Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - gamma -Interferon KW - T-cell receptor KW - Gene therapy KW - double prime T-cell receptor KW - Development KW - Clinical trials KW - Cancer KW - p53 protein KW - Blood KW - Antibodies KW - Constant region KW - Genetic engineering KW - Antigen (tumor-associated) KW - Glycoprotein gp100 KW - Lymphocytes T KW - Immune response KW - Immune response (humoral) KW - Variable region KW - W 30905:Medical Applications KW - G 07880:Human Genetics KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874179836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Development+of+Human+Anti-Murine+T-Cell+Receptor+Antibodies+in+Both+Responding+and+Nonresponding+Patients+Enrolled+in+TCR+Gene+Therapy+Trials&rft.au=Davis%2C+Jeremy+L%3BTheoret%2C+Marc+R%3BZheng%2C+Zhili%3BLamers%2C+Cor+HJ%3BRosenberg%2C+Steven+A%3BMorgan%2C+Richard+A&rft.aulast=Davis&rft.aufirst=Jeremy&rft.date=2010-12-01&rft.volume=16&rft.issue=23&rft.spage=5852&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; T-cell receptor; Gene therapy; double prime T-cell receptor; Development; Clinical trials; Cancer; p53 protein; Blood; Antibodies; Constant region; Genetic engineering; Glycoprotein gp100; Antigen (tumor-associated); Lymphocytes T; Immune response; Immune response (humoral); Variable region ER - TY - JOUR T1 - Coxiella burnetii Expresses a Functional 24 Sterol Reductase AN - 872137734; 14036266 AB - Coxiella burnetii, the etiological agent of human Q fever, occupies a unique niche inside the host cell, where it replicates in a modified acidic phagolysosome or parasitophorous vacuole (PV). The PV membrane is cholesterol-rich, and inhibition of host cholesterol metabolism negatively impacts PV biogenesis and pathogen replication. The precise source(s) of PV membrane cholesterol is unknown, as is whether the bacterium actively diverts and/or modifies host cell cholesterol or sterol precursors. C. burnetii lacks enzymes for de novo cholesterol biosynthesis; however, the organism encodes a eukaryote-like 24 sterol reductase homolog, CBU1206. Absent in other prokaryotes, this enzyme is predicted to reduce sterol double bonds at carbon 24 in the final step of cholesterol or ergosterol biosynthesis. In the present study, we examined the functional activity of CBU1206. Amino acid alignments revealed the greatest sequence identity (51.7%) with a 24 sterol reductase from the soil amoeba Naegleria gruberi. CBU1206 activity was examined by expressing the protein in a Saccharomyces cerevisiae erg4 mutant under the control of a galactose-inducible promoter. Erg4 is a yeast 24 sterol reductase responsible for the final reduction step in ergosterol synthesis. Like Erg4-green fluorescent protein (GFP), a CBU1206-GFP fusion protein localized to the yeast endoplasmic reticulum. Heterologous expression of CBU1206 rescued S. cerevisiae erg4 sensitivity to growth in the presence of brefeldin A and cycloheximide and resulted in new synthesis of ergosterol. These data indicate CBU1206 is an active sterol reductase and suggest the enzyme may act on host sterols during C. burnetii intracellular growth. JF - Journal of Bacteriology AU - Gilk, Stacey D AU - Beare, Paul A AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, rheinzen@niaid.nih.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 6154 EP - 6159 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 192 IS - 23 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Cycloheximide KW - Amoeba KW - double prime Q fever KW - Soil KW - Coxiella burnetii KW - Endoplasmic reticulum KW - Promoters KW - Carbon KW - reductase KW - Sterols KW - Brefeldin A KW - Prokaryotes KW - Data processing KW - Replication KW - Enzymes KW - Cholesterol KW - Pathogens KW - Saccharomyces cerevisiae KW - Lipid metabolism KW - parasitophorous vacuole KW - Phagolysosomes KW - Fusion protein KW - Ergosterol KW - Naegleria gruberi KW - Amino acid sequence KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872137734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Coxiella+burnetii+Expresses+a+Functional+24+Sterol+Reductase&rft.au=Gilk%2C+Stacey+D%3BBeare%2C+Paul+A%3BHeinzen%2C+Robert+A&rft.aulast=Gilk&rft.aufirst=Stacey&rft.date=2010-12-01&rft.volume=192&rft.issue=23&rft.spage=6154&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.00818-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Number of references - 27 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Data processing; Replication; Cycloheximide; Enzymes; Pathogens; Cholesterol; double prime Q fever; Lipid metabolism; parasitophorous vacuole; Soil; Promoters; Endoplasmic reticulum; Phagolysosomes; reductase; Carbon; Sterols; Brefeldin A; Fusion protein; Prokaryotes; Ergosterol; Amino acid sequence; Coxiella burnetii; Amoeba; Naegleria gruberi; Saccharomyces cerevisiae DO - http://dx.doi.org/10.1128/JB.00818-10 ER - TY - JOUR T1 - Acetate accumulation through alternative metabolic pathways in ackA super(-) pta super(-) poxB super(-) triple mutant in E. coli B (BL21) AN - 856769393; 14238612 AB - Individual deletions of acs and aceA genes in E. coli B (BL21) showed little difference in the metabolite accumulation patterns but deletion of the ackA gene alone or together with pta showed acetic acid gradually accumulated to 3.1 and 1.7g/l, respectively, with a minimal extended lag in bacterial growth and a higher pyruvate formation. Single poxB deletion in E. coli B (BL21) or additional poxB deletion in the ackA-pta mutants did not change the acetate accumulation pattern. When the acetate production genes (ackA-pta-poxB) were deleted in E. coli B (BL21) acetate still accumulated. This may be an indication that perhaps acetate is not only a by-product of carbon metabolism; it is possible that acetate plays also a role in other cellular metabolite pathways. It is likely that there are alternative acetate production pathways. JF - Biotechnology Letters AU - Phue, Je-Nie AU - Lee, Sang Jun AU - Kaufman, Jeanne B AU - Negrete, Alejandro AU - Shiloach, Joseph AD - Biotechnology Core Laboratory, NIDDK NIH Bethesda, Bldg 14A Room 173, Bethesda, MD, 20892, USA, yossi@nih.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 1897 EP - 1903 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 32 IS - 12 SN - 0141-5492, 0141-5492 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Gene deletion KW - Carbon KW - Pyruvic acid KW - Escherichia coli KW - Metabolic pathways KW - Metabolites KW - Acetic acid KW - J 02320:Cell Biology KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856769393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+Letters&rft.atitle=Acetate+accumulation+through+alternative+metabolic+pathways+in+ackA+super%28-%29+pta+super%28-%29+poxB+super%28-%29+triple+mutant+in+E.+coli+B+%28BL21%29&rft.au=Phue%2C+Je-Nie%3BLee%2C+Sang+Jun%3BKaufman%2C+Jeanne+B%3BNegrete%2C+Alejandro%3BShiloach%2C+Joseph&rft.aulast=Phue&rft.aufirst=Je-Nie&rft.date=2010-12-01&rft.volume=32&rft.issue=12&rft.spage=1897&rft.isbn=&rft.btitle=&rft.title=Biotechnology+Letters&rft.issn=01415492&rft_id=info:doi/10.1007%2Fs10529-010-0369-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Gene deletion; Pyruvic acid; Carbon; Metabolic pathways; Metabolites; Acetic acid; Escherichia coli DO - http://dx.doi.org/10.1007/s10529-010-0369-7 ER - TY - JOUR T1 - Content Licensing Buying and Selling Digital Resources, AN - 855900789; 201101665 AB - Book review abstract. Content Licensing: Buying and Selling Digital Resources. By Michael Upshall. Oxford, UK: Chandos Publishing, 2009, 136pp., 95.00 USD. ISBN 978-84334-2. Reviewed by Betty Landesman. [Copyright Elsevier Inc.] JF - Serials Review AU - Landesman, Betty AU - Landesman, Betty AD - Digital Resources and Metadata, National Institutes of Health Library Bethesda, MD 20892-1150, USA landesb@mail.nih.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 272 PB - Elsevier, San Diego CA VL - 36 IS - 4 SN - 0098-7913, 0098-7913 KW - Purchasing KW - Licensing KW - Electronic media KW - article KW - 1.11: BOOK REVIEWS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855900789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Serials+Review&rft.atitle=Content+Licensing+Buying+and+Selling+Digital+Resources%2C&rft.au=Landesman%2C+Betty&rft.aulast=Landesman&rft.aufirst=Betty&rft.date=2010-12-01&rft.volume=36&rft.issue=4&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=Serials+Review&rft.issn=00987913&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Licensing; Purchasing; Electronic media ER - TY - JOUR T1 - Brominated and Chlorinated Flame Retardants: The San Antonio Statement AN - 855715874; 14160346 AB - Abstract not available. JF - Environmental Health Perspectives AU - Birnbaum, Linda S AU - Bergman, Aake AD - Director, NIEHS and NTP, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, birnbaumls@niehs.nih.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - A514 EP - A515 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 118 IS - 2 SN - 0091-6765, 0091-6765 KW - Environment Abstracts KW - Chile, Atacama, San Antonio KW - Fire retardants KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855715874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Brominated+and+Chlorinated+Flame+Retardants%3A+The+San+Antonio+Statement&rft.au=Birnbaum%2C+Linda+S%3BBergman%2C+Aake&rft.aulast=Birnbaum&rft.aufirst=Linda&rft.date=2010-12-01&rft.volume=118&rft.issue=2&rft.spage=A514&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1003088 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2016-09-14 N1 - SubjectsTermNotLitGenreText - Fire retardants; Chile, Atacama, San Antonio DO - http://dx.doi.org/10.1289/ehp.1003088 ER - TY - JOUR T1 - The effect of protein structure on their controlled release from an injectable peptide hydrogel AN - 855688148; 14039955 AB - Hydrogel materials are promising vehicles for the delivery of protein therapeutics. Proteins can impart physical interactions, both steric and electrostatic in nature, that influence their release from a given gel network. Here, model proteins of varying hydrodynamic diameter and charge are directly encapsulated and their release studied from electropositive fibrillar hydrogels prepared from the self-assembling peptide, MAX8. Hydrogelation of MAX8 can be triggered in the presence of proteins for their direct encapsulation with neither effect on protein structure nor the hydrogel's mechanical properties. Bulk release of the encapsulated proteins from the hydrogels was assessed for a month time period at 37aaA degree C before and after syringe delivery of the loaded gels to determine the influence of the protein structure on release. Release of positively charged and neutral proteins was largely governed by the sterics imposed by the network. Conversely, negatively charged proteins interacted strongly with the positively charged fibrillar network, greatly restricting their release to <10% of the initial protein load. Partition and retention studies indicated that electrostatic interactions dictate the amount of protein available for release. Importantly, when protein encapsulated gels were delivered via syringe, the release profiles of the macromolecules show the similar trends as those observed for non-sheared gels. This study demonstrates that proteins can be directly encapsulated in self assembled MAX8 hydrogels, which can then be syringe delivered to a site where subsequent release is controlled by protein structure. JF - Biomaterials AU - Branco, Monica C AU - Pochan, Darrin J AU - Wagner, Norman J AU - Schneider, Joel P AD - Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21701, USA Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 9527 EP - 9534 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 31 IS - 36 SN - 0142-9612, 0142-9612 KW - Biotechnology and Bioengineering Abstracts KW - Peptide KW - Hydrogel KW - Delivery KW - Protein KW - Syringe KW - (BSA) KW - (IgG) KW - Protein structure KW - Macromolecules KW - hydrogels KW - Hydrodynamics KW - Syringes KW - Self KW - Electrostatic properties KW - Controlled release KW - Encapsulation KW - Models KW - Mechanical properties KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855688148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=The+effect+of+protein+structure+on+their+controlled+release+from+an+injectable+peptide+hydrogel&rft.au=Branco%2C+Monica+C%3BPochan%2C+Darrin+J%3BWagner%2C+Norman+J%3BSchneider%2C+Joel+P&rft.aulast=Branco&rft.aufirst=Monica&rft.date=2010-12-01&rft.volume=31&rft.issue=36&rft.spage=9527&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=01429612&rft_id=info:doi/10.1016%2Fj.biomaterials.2010.08.047 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Protein structure; Macromolecules; Hydrodynamics; hydrogels; Self; Syringes; Electrostatic properties; Controlled release; Mechanical properties; Models; Encapsulation DO - http://dx.doi.org/10.1016/j.biomaterials.2010.08.047 ER - TY - JOUR T1 - Gene pathways and subnetworks distinguish between major glioma subtypes and elucidate potential underlying biology AN - 855687551; 14042004 AB - Molecular diagnostic tools are increasingly being used in an attempt to classify primary human brain tumors more accurately. While methods that are based on the analysis of individual gene expression prove to be useful for diagnostic purposes, they are devoid of biological significance since tumorgenesis is a concerted deregulation of multiple pathways rather than single genes. In a proof of concept, we utilize two large clinical data sets and show that the elucidation of enriched pathways and small differentially expressed sub-networks of protein interactions allow a reliable classification of glioblastomas and oligodendrogliomas. Applying a feature selection method, we observe that an optimized subset of pathways and subnetworks significantly improves the prediction accuracy. By determining the enrichment of altered genes in pathways and subnetworks we show that optimized subsets of genes rarely seem to be a target of genomic alteration. Our results suggest that groups of genes play a decisive role for the phenotype of the underlying tumor samples that can be utilized to reliably distinguish tumor types. In the absence of enrichment of genes that are genomically altered we assume that genetic changes largely exert an indirect rather than direct regulatory influence on a number of tumor-defining regulatory networks. JF - Journal of Biomedical Informatics AU - Wuchty, Stefan AU - Zhang, Alice AU - Walling, Jennifer AU - Ahn, Susie AU - Li, Aiguo AU - Quezado, Martha AU - Oberholtzer, Carl AU - Zenklusen, Jean-Claude AU - Fine, Howard A AD - Neuro-Oncology Branch, National Cancer Institute, National Institutes of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, MD 20894, USA Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 945 EP - 952 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 43 IS - 6 SN - 1532-0464, 1532-0464 KW - Genetics Abstracts; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Classification KW - Gliomas KW - Subnetworks KW - Pathways KW - Brain tumors KW - Gene expression KW - Glioblastoma KW - Data processing KW - oligodendroglioma KW - Bioinformatics KW - genomics KW - Glioma KW - Protein interaction KW - G 07880:Human Genetics KW - N3 11007:Neurobiology KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855687551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Informatics&rft.atitle=Gene+pathways+and+subnetworks+distinguish+between+major+glioma+subtypes+and+elucidate+potential+underlying+biology&rft.au=Wuchty%2C+Stefan%3BZhang%2C+Alice%3BWalling%2C+Jennifer%3BAhn%2C+Susie%3BLi%2C+Aiguo%3BQuezado%2C+Martha%3BOberholtzer%2C+Carl%3BZenklusen%2C+Jean-Claude%3BFine%2C+Howard+A&rft.aulast=Wuchty&rft.aufirst=Stefan&rft.date=2010-12-01&rft.volume=43&rft.issue=6&rft.spage=945&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Informatics&rft.issn=15320464&rft_id=info:doi/10.1016%2Fj.jbi.2010.08.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Gene expression; Brain tumors; Glioblastoma; Data processing; oligodendroglioma; Glioma; genomics; Bioinformatics; Protein interaction DO - http://dx.doi.org/10.1016/j.jbi.2010.08.011 ER - TY - JOUR T1 - Reconstructing the pipeline by introducing multiplexed multiple reaction monitoring mass spectrometry for cancer biomarker verification: An NCI-CPTC initiative perspective AN - 853488582; 14337840 AB - Proteomics holds great promise in personalized medicine for cancer in the post-genomic era. In the past decade, clinical proteomics has significantly evolved in terms of technology development, optimization and standardization, as well as in advanced bioinformatics data integration and analysis. Great strides have been made for characterizing a large number of proteins qualitatively and quantitatively in a proteome, including the use of sample fractionation, protein microarrays and MS. It is believed that differential proteomic analysis of high-quality clinical biospecimen (tissue and biofluids) can potentially reveal protein/peptide biomarkers responsible for cancer by means of their altered levels of expression and/or PTMs. Multiple reaction monitoring, a multiplexed platform using stable isotope dilution-MS with sensitivity and reproducibility approaching that of traditional ELISAs commonly used in the clinical setting, has emerged as a potentially promising technique for next-generation high-throughput protein biomarker measurements for diagnostics and therapeutics. JF - Proteomics Clinical Applications AU - Rodriguez, H AU - Rivers, R AU - Kinsinger, C AU - Mesri, M AU - Hiltke, T AU - Rahbar, A AU - Boja, E AD - Room 10A52, 31 Center Drive, MSC 2580, Bethesda, MD 20892, USA, bojae@mail.nih.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 904 EP - 914 VL - 4 IS - 12 SN - 1862-8346, 1862-8346 KW - Biotechnology and Bioengineering Abstracts KW - Enzyme-linked immunosorbent assay KW - Isotopes KW - Data processing KW - Therapeutic applications KW - biomarkers KW - Cancer KW - Mass spectroscopy KW - Integration KW - Standardization KW - Protein arrays KW - proteomics KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853488582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics+Clinical+Applications&rft.atitle=Reconstructing+the+pipeline+by+introducing+multiplexed+multiple+reaction+monitoring+mass+spectrometry+for+cancer+biomarker+verification%3A+An+NCI-CPTC+initiative+perspective&rft.au=Rodriguez%2C+H%3BRivers%2C+R%3BKinsinger%2C+C%3BMesri%2C+M%3BHiltke%2C+T%3BRahbar%2C+A%3BBoja%2C+E&rft.aulast=Rodriguez&rft.aufirst=H&rft.date=2010-12-01&rft.volume=4&rft.issue=12&rft.spage=904&rft.isbn=&rft.btitle=&rft.title=Proteomics+Clinical+Applications&rft.issn=18628346&rft_id=info:doi/10.1002%2Fprca.201000057 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Standardization; Integration; Isotopes; Enzyme-linked immunosorbent assay; Data processing; Protein arrays; Therapeutic applications; Bioinformatics; proteomics; biomarkers; Mass spectroscopy; Cancer DO - http://dx.doi.org/10.1002/prca.201000057 ER - TY - JOUR T1 - Effects of prenatal exposure to a low dose atrazine metabolite mixture on pubertal timing and prostate development of male Long-Evans rats AN - 853475415; 14042339 AB - The present study examines the postnatal reproductive development of male rats following prenatal exposure to an atrazine metabolite mixture (AMM) consisting of the herbicide atrazine and its environmental metabolites diaminochlorotriazine, hydroxyatrazine, deethylatrazine, and deisopropylatrazine. Pregnant Long-Evans rats were treated by gavage with 0.09, 0.87, or 8.73mg AMM/kg body weight (BW), vehicle, or 100mg ATR/kg BW positive control, on gestation days 15-19. Preputial separation was significantly delayed in 0.87mg and 8.73mg AMM-exposed males. AMM-exposed males demonstrated a significant treatment-related increase in incidence and severity of inflammation in the prostate on postnatal day (PND) 120. A dose-dependent increase in epididymal fat masses and prostate foci were grossly visible in AMM-exposed offspring. These results indicate that a short, late prenatal exposure to mixture of chlorotriazine metabolites can cause chronic prostatitis in male LE rats. The mode of action for these effects is presently unclear. JF - Reproductive Toxicology AU - Stanko, Jason P AU - Enoch, Rolondo R AU - Rayner, Jennifer L AU - Davis, Christine C AU - Wolf, Douglas C AU - Malarkey, David E AU - Fenton, Suzanne E AD - Reproductive Toxicology Division, US Environmental Protection Agency (US EPA), ORD/NHEERL, Research Triangle Park, NC 27711, United States, fentonse@niehs.nih.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 540 EP - 549 PB - Elsevier Science, Box 882 New York NY 10159 USA VL - 30 IS - 4 SN - 0890-6238, 0890-6238 KW - Toxicology Abstracts KW - Prenatal experience KW - Metabolites KW - Herbicides KW - Inflammation KW - Pregnancy KW - Prostatitis KW - Body weight KW - Atrazine KW - Gestation KW - Body fat KW - Progeny KW - Prostate KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853475415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=Effects+of+prenatal+exposure+to+a+low+dose+atrazine+metabolite+mixture+on+pubertal+timing+and+prostate+development+of+male+Long-Evans+rats&rft.au=Stanko%2C+Jason+P%3BEnoch%2C+Rolondo+R%3BRayner%2C+Jennifer+L%3BDavis%2C+Christine+C%3BWolf%2C+Douglas+C%3BMalarkey%2C+David+E%3BFenton%2C+Suzanne+E&rft.aulast=Stanko&rft.aufirst=Jason&rft.date=2010-12-01&rft.volume=30&rft.issue=4&rft.spage=540&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/10.1016%2Fj.reprotox.2010.07.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Prostatitis; Prenatal experience; Body weight; Gestation; Atrazine; Body fat; Herbicides; Progeny; Metabolites; Prostate; Pregnancy; Inflammation DO - http://dx.doi.org/10.1016/j.reprotox.2010.07.006 ER - TY - JOUR T1 - Adapting Semantic Natural Language Processing Technology to Address Information Overload in Influenza Epidemic Management AN - 853213614; 201101334 AB - The explosion of disaster health information results in information overload among response professionals. The objective of this project was to determine the feasibility of applying semantic natural language processing (NLP) technology to addressing this overload. The project characterizes concepts and relationships commonly used in disaster health-related documents on influenza pandemics, as the basis for adapting an existing semantic summarizer to the domain. Methods include human review and semantic NLP analysis of a set of relevant documents. This is followed by a pilot test in which two information specialists use the adapted application for a realistic information-seeking task. According to the results, the ontology of influenza epidemics management can be described via a manageable number of semantic relationships that involve concepts from a limited number of semantic types. Test users demonstrate several ways to engage with the application to obtain useful information. This suggests that existing semantic NLP algorithms can be adapted to support information summarization and visualization in influenza epidemics and other disaster health areas. However, additional research is needed in the areas of terminology development (as many relevant relationships and terms are not part of existing standardized vocabularies), NLP, and user interface design. [Copyright Wiley Periodicals Inc.] JF - Journal of the American Society for Information Science and Technology AU - Keselman, Alla AU - Rosemblat, Graciela AU - Kilicoglu, Halil AU - Fiszman, Marcelo AU - Jin, Honglan AU - Shin, Dongwook AU - Rindflesch, Thomas C AD - National Library of Medicine, Bethesda, MD keselmana@mail.nih.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 2531 EP - 2543 PB - Wiley Subscription Services, Hoboken NJ VL - 61 IS - 12 SN - 1532-2882, 1532-2882 KW - Information overload KW - Natural language processing KW - Diseases KW - Semantics KW - article KW - 13.13: AUTOMATIC TEXT ANALYSIS, AUTOMATIC INDEXING, MACHINE TRANSLATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853213614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+for+Information+Science+and+Technology&rft.atitle=Adapting+Semantic+Natural+Language+Processing+Technology+to+Address+Information+Overload+in+Influenza+Epidemic+Management&rft.au=Keselman%2C+Alla%3BRosemblat%2C+Graciela%3BKilicoglu%2C+Halil%3BFiszman%2C+Marcelo%3BJin%2C+Honglan%3BShin%2C+Dongwook%3BRindflesch%2C+Thomas+C&rft.aulast=Keselman&rft.aufirst=Alla&rft.date=2010-12-01&rft.volume=61&rft.issue=12&rft.spage=2531&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+for+Information+Science+and+Technology&rft.issn=15322882&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2011-02-16 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Natural language processing; Information overload; Semantics; Diseases ER - TY - JOUR T1 - Perception of facial emotion in adults with bipolar or unipolar depression and controls AN - 853208996; 201106214 AB - Previous research indicates that patients with depression display deficits in their ability to perceive emotions. However, few studies have used animated facial stimuli or explored sensitivity to facial expressions in depressed individuals. Moreover, limited research is available on facial processing in unipolar versus bipolar depression. In this study, 34 patients with DSM-IV major depressive disorder (MDD), 21 patients with DSM-IV bipolar disorder (BPD) in the depressed phase, and 24 never-depressed controls completed the Emotional Expression Multimorph Task, which presents facial emotions in gradations from neutral to 100% emotional expression (happy, sad, surprised, fearful, angry, and disgusted). Groups were compared in terms of sensitivity and accuracy in identifying emotions. Our preliminary findings suggest that subjects with bipolar depression may have emotional processing abnormalities relative to controls. [Copyright Elsevier Ltd.] JF - Journal of Psychiatric Research AU - Schaefer, Kathryn L AU - Baumann, Jacqueline AU - Rich, Brendan A AU - Luckenbaugh, David A AU - Zarate, Carlos A, Jr AD - Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 1229 EP - 1235 PB - Elsevier Ltd, Oxford UK VL - 44 IS - 16 SN - 0022-3956, 0022-3956 KW - Bipolar disorder (BPD) Cognition Facial expression Emotion perception Unipolar depression KW - Depressive personality disorders KW - Sensitivity KW - Emotions KW - Visual processing KW - Facial expressions KW - Bipolar affective disorder KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853208996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychiatric+Research&rft.atitle=Perception+of+facial+emotion+in+adults+with+bipolar+or+unipolar+depression+and+controls&rft.au=Schaefer%2C+Kathryn+L%3BBaumann%2C+Jacqueline%3BRich%2C+Brendan+A%3BLuckenbaugh%2C+David+A%3BZarate%2C+Carlos+A%2C+Jr&rft.aulast=Schaefer&rft.aufirst=Kathryn&rft.date=2010-12-01&rft.volume=44&rft.issue=16&rft.spage=1229&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychiatric+Research&rft.issn=00223956&rft_id=info:doi/10.1016%2Fj.jpsychires.2010.04.024 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-02-16 N1 - Last updated - 2016-09-27 N1 - CODEN - JPYRA3 N1 - SubjectsTermNotLitGenreText - Bipolar affective disorder; Emotions; Facial expressions; Sensitivity; Depressive personality disorders; Visual processing DO - http://dx.doi.org/10.1016/j.jpsychires.2010.04.024 ER - TY - JOUR T1 - Intracellular Traffic of Oligodeoxynucleotides In and Out of the Nucleus: Effect of Exportins and DNA Structure AN - 851468974; 14299214 AB - The delivery of oligodeoxynucleotides (ODNs) into cells is widely utilized for antisense, antigene, aptamer, and similar approaches to regulate gene and protein activities based upon the ODNs' sequence-specific recognition. Short pieces of DNA can also be generated in biological processes, for example, after degradation of viral or bacterial DNA. However, the mechanisms that regulate intracellular trafficking and localization of ODNs are not fully understood. Here we study the effects of major transporters of microRNA, exportin-1 (Exp1) and exportin-5 (Exp5), on the transport of single-stranded ODNs in and out of the nucleus. For this, we employed a fluorescent microscopy-based assay to quantitatively measure the redistribution of ODNs between the nucleus and cytoplasm of live cells. By measuring the fluorescent signal of the nuclei we observed that after delivery into cells via cationic liposomes ODNs rapidly accumulated inside nuclei. However, after removal of the ODN/liposome containing media, we found re-localization of ODNs from the nuclei to cytoplasm of the cells over the time course of several hours. Downregulation of the Exp5 gene by siRNA resulted in a slight increase of ODN uptake into the nucleus, but the kinetics of ODN efflux to the cytoplasm was not affected. Inhibition of Exp1 with leptomycin B somewhat slowed down the clearance of ODNs from the nucleus; however, within 6 hours most of the ODN were still being cleared form the nucleus. ODNs that could form intramolecular G-quadruplex structures behaved differently. They also accumulated in nuclei, although at a lesser extent than unstructured ODN, but they remained there for up to 20 hours after transfection, causing significant cell death. We conclude that Exp1 and Exp5 are not the major transporters of our ODNs out of the nucleus, and that the transport of ODNs is strongly affected by their secondary structure. JF - Oligonucleotides AU - Forsha, S J AU - Panyutin, I V AU - Neumann, R D AU - Panyutin, I G AD - Radiology and Imaging Sciences Department Clinical Center National Institutes of Health Bethesda, MD 20892, igorp@helix.nih.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 277 EP - 284 VL - 20 IS - 6 SN - 1545-4576, 1545-4576 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Aptamers KW - Media (transport) KW - Secondary structure KW - miRNA KW - Liposomes KW - Oligonucleotides KW - Protein structure KW - Antisense KW - Cell death KW - DNA structure KW - siRNA KW - Transfection KW - Kinetics KW - Cytoplasm KW - leptomycin B KW - Karyopherins KW - Nuclei KW - W 30940:Products KW - V 22340:Antiviral Agents KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/851468974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oligonucleotides&rft.atitle=Intracellular+Traffic+of+Oligodeoxynucleotides+In+and+Out+of+the+Nucleus%3A+Effect+of+Exportins+and+DNA+Structure&rft.au=Forsha%2C+S+J%3BPanyutin%2C+I+V%3BNeumann%2C+R+D%3BPanyutin%2C+I+G&rft.aulast=Forsha&rft.aufirst=S&rft.date=2010-12-01&rft.volume=20&rft.issue=6&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Oligonucleotides&rft.issn=15454576&rft_id=info:doi/10.1089%2Foli.2010.0255 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Aptamers; Media (transport); miRNA; Secondary structure; Oligonucleotides; Liposomes; Protein structure; Cell death; Antisense; DNA structure; siRNA; Transfection; Cytoplasm; Kinetics; leptomycin B; Nuclei; Karyopherins DO - http://dx.doi.org/10.1089/oli.2010.0255 ER - TY - JOUR T1 - Reversible Projection Technique for Colon Unfolding AN - 849460819; 14109925 AB - Colon unfolding provides an efficient way to navigate the colon in computed tomographic colonography (CTC). Most existing unfolding techniques only compute forward projections. When radiologists find abnormalities or conduct measurements on the unfolded view (which is often quicker and easier), it is difficult to locate the corresponding region on the 3-D view for further examination (which is more accurate and reliable). To address this, we propose a reversible projection technique for colon unfolding. The method makes use of advanced algorithms including rotation-minimizing frames, recursive ring sets, mesh skinning, and cylindrical projection. Both forward and reverse mapping can be computed for points on the colon surface. Therefore, it allows for detecting and measuring polyps on the unfolded view and mapping them back to the 3-D surface. We generated realistic colon simulation data incorporating most colon characteristics, such as curved centerline, variable distention, haustral folds, teniae coli, and colonic polyps. Our method was tested on both simulated data and data from 110 clinical CTC studies. The results showed submillimeter accuracy in simulated data and -0.23 plus or minus 1.67 mm in the polyp measurement using clinical CTC data. The major contributions of our technique are: 1) the use of a recursive ring set method to solve the centerline and surface correspondence problem; 2) reverse transformation from the unfolded view to the 3-D view; and 3) quantitative validation using a realistic colon simulation and clinical CTC polyp measurement. JF - IEEE Transactions on Biomedical Engineering AU - Yao, Jianhua AU - Chowdhury, Ananda S AU - Aman, Javed AU - Summers, Ronald M AD - National Institutes of Health , Bethesda, MD, USA Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 2861 EP - 2869 PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 USA VL - 57 IS - 12 SN - 0018-9294, 0018-9294 KW - Biotechnology and Bioengineering Abstracts KW - Transformation KW - Data processing KW - Skin KW - Colon KW - Energy KW - Computed tomography KW - Algorithms KW - Polyps KW - Mapping KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849460819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=IEEE+Transactions+on+Biomedical+Engineering&rft.atitle=Reversible+Projection+Technique+for+Colon+Unfolding&rft.au=Yao%2C+Jianhua%3BChowdhury%2C+Ananda+S%3BAman%2C+Javed%3BSummers%2C+Ronald+M&rft.aulast=Yao&rft.aufirst=Jianhua&rft.date=2010-12-01&rft.volume=57&rft.issue=12&rft.spage=2861&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Biomedical+Engineering&rft.issn=00189294&rft_id=info:doi/10.1109%2FTBME.2010.2052255 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Transformation; Skin; Data processing; Colon; Energy; Computed tomography; Algorithms; Polyps; Mapping DO - http://dx.doi.org/10.1109/TBME.2010.2052255 ER - TY - JOUR T1 - Comparison of electroconvulsive therapy (ECT) with or without anti-epileptic drugs in bipolar disorder AN - 839582492; 201104430 AB - Background Guidelines regarding the combination of anti-epileptic drugs (AEDs) and ECT have been contradictory. Evidence based knowledge about the advantages and disadvantages of this combination is sparse. Method We studied the records of consecutive non-epileptic bipolar disorder patients referred for ECT between the months of January 2006 and January 2008 in an academic psychiatric hospital. Seizure threshold, failure to achieve adequate seizures, maximum electrical charge received and the number of ECTs administered were compared between those who were on AEDs during ECT (AED patients; n = 79) and those who were not on AEDs (NAED patients; n = 122). Two raters who achieved good inter-rater reliability assessed the clinical outcome from the records using the Clinical Global Impression (CGI) scale. Results AED patients had significantly greater proportion of males, longer duration of episode and treatment and higher co morbidity. AED patients had significantly higher seizure threshold, higher incidence of failure to obtain seizures and shorter duration of motor seizures. Both groups achieved comparable symptomatic improvement at the end of the ECT course [Mean (SD) CGI-I = 2.0 (0.4) and 1.96 (0.3) in AED and NAED patients respectively; t = 1.4; p = 0.15]. However, AED patients had received significantly higher number of ECT sessions [mean (SD) = 7.9 (3.0)] than NAED patients [mean (SD) = 6.3 (2.1); t = 4.3; p < 0.01] and stayed for significantly longer time (days) in the hospital [Mean (SD) 25.1 (16.1) and 20.6 (10.5) in AED and NAED patients respectively; t = 2.4; p = 0.02]. The difference in the outcome remained significant even after controlling for the effects of duration of illness, gender, drug treatment and presence of co morbidity. Conclusions Symptomatic improvement of patients who are on AEDS during ECT is comparable to those who are not. However, AED patients required a significantly higher number of ECT sessions to achieve this. Prospective studies are required to confirm these findings and also to compare cognitive adverse effects. [Copyright Elsevier B.V.] JF - Journal of Affective Disorders AU - Virupaksha, Harve Shanmugam AU - Shashidhara, Barki AU - Thirthalli, Jagadisha AU - Kumar, Channaveerachari Naveen AU - Gangadhar, Bangalore N AD - Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 66 EP - 70 PB - Elsevier Ltd, The Netherlands VL - 127 IS - 1-3 SN - 0165-0327, 0165-0327 KW - Anti-epileptic drugs (AED) Bipolar disorder Electroconvulsive therapy (ECT) KW - Seizure KW - Electroconvulsive therapy KW - Bipolar affective disorder KW - Thresholds KW - Morbidity KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839582492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Affective+Disorders&rft.atitle=Comparison+of+electroconvulsive+therapy+%28ECT%29+with+or+without+anti-epileptic+drugs+in+bipolar+disorder&rft.au=Virupaksha%2C+Harve+Shanmugam%3BShashidhara%2C+Barki%3BThirthalli%2C+Jagadisha%3BKumar%2C+Channaveerachari+Naveen%3BGangadhar%2C+Bangalore+N&rft.aulast=Virupaksha&rft.aufirst=Harve&rft.date=2010-12-01&rft.volume=127&rft.issue=1-3&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Journal+of+Affective+Disorders&rft.issn=01650327&rft_id=info:doi/10.1016%2Fj.jad.2010.05.008 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Electroconvulsive therapy; Seizure; Morbidity; Thresholds; Bipolar affective disorder; Hospitals DO - http://dx.doi.org/10.1016/j.jad.2010.05.008 ER - TY - JOUR T1 - The neural correlates of Neuroticism differ by sex prospectively mediate depressive symptoms among older women AN - 839577637; 201104101 AB - Background Mood disorders in old age increase the risk of morbidity and mortality for individuals and healthcare costs for society. Trait Neuroticism, a strong risk factor for such disorders into old age, shares common genetic variance with depression, but the more proximal biological mechanisms that mediate this connection are not well understood. Further, whether sex differences in the neural correlates of Neuroticism mirror sex differences in behavioral measures is unknown. The present research identifies sex differences in the stable neural activity associated with Neuroticism and tests whether this activity prospectively mediates Neuroticism and subsequent depressive symptoms. Methods A total of 100 (46 female) older participants (> 55 years) underwent a resting-state PET scan twice, approximately two years apart, and completed measures of Neuroticism and depressive symptoms twice. Results Replicating at both time points, Neuroticism correlated positively with resting-state regional cerebral blood-flow activity in the hippocampus and midbrain in women and the middle temporal gyrus in men. For women, hippocampal activity mediated the association between Neuroticism at baseline and depressive symptoms at follow-up. The reverse mediational model was not significant. Conclusions Neuroticism was associated with stable neural activity in regions implicated in emotional processing and regulation for women but not men. Among women, Neuroticism prospectively predicted depressive symptoms through greater activity in the right hippocampus, suggesting one neural mechanism between Neuroticism and depression for women. Identifying responsible mechanisms for the association between Neuroticism and psychiatric disorders may help guide research on pharmacological interventions for such disorders across the lifespan. [Copyright Elsevier B.V.] JF - Journal of Affective Disorders AU - Sutin, Angelina R AU - Beason-Held, Lori L AU - Dotson, Vonetta M AU - Resnick, Susan M AU - Costa, Paul T, Jr AD - Laboratory of Personality and Cognition, National Institute on Aging, NIH, DHHS, United States sutina@mail.nih.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 241 EP - 247 PB - Elsevier Ltd, The Netherlands VL - 127 IS - 1-3 SN - 0165-0327, 0165-0327 KW - Neuroticism Depression PET imaging Hippocampus Mediation Sex differences KW - Depression KW - Hippocampus KW - Neuroticism KW - Women KW - Gender differences KW - Morbidity-Mortality KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839577637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Affective+Disorders&rft.atitle=The+neural+correlates+of+Neuroticism+differ+by+sex+prospectively+mediate+depressive+symptoms+among+older+women&rft.au=Sutin%2C+Angelina+R%3BBeason-Held%2C+Lori+L%3BDotson%2C+Vonetta+M%3BResnick%2C+Susan+M%3BCosta%2C+Paul+T%2C+Jr&rft.aulast=Sutin&rft.aufirst=Angelina&rft.date=2010-12-01&rft.volume=127&rft.issue=1-3&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Journal+of+Affective+Disorders&rft.issn=01650327&rft_id=info:doi/10.1016%2Fj.jad.2010.06.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Neuroticism; Depression; Women; Gender differences; Hippocampus; Morbidity-Mortality DO - http://dx.doi.org/10.1016/j.jad.2010.06.004 ER - TY - JOUR T1 - Extending the reach, effectiveness, and efficiency of communication: Evidence from the centers of excellence in cancer communication research AN - 839572124; 201101799 AB - Abstract not available. JF - Patient Education and Counseling AU - Hesse, Bradford William AU - Johnson, Lenora Eulene AU - Davis, Kia Latrece AD - National Cancer Institute, USA hesseb@mail.nih.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - S1 EP - S5 PB - Elsevier Ltd, The Netherlands VL - 81 SN - 0738-3991, 0738-3991 KW - Doctor-Patient communication KW - Health information KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839572124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Patient+Education+and+Counseling&rft.atitle=Extending+the+reach%2C+effectiveness%2C+and+efficiency+of+communication%3A+Evidence+from+the+centers+of+excellence+in+cancer+communication+research&rft.au=Hesse%2C+Bradford+William%3BJohnson%2C+Lenora+Eulene%3BDavis%2C+Kia+Latrece&rft.aulast=Hesse&rft.aufirst=Bradford&rft.date=2010-12-01&rft.volume=81&rft.issue=&rft.spage=S1&rft.isbn=&rft.btitle=&rft.title=Patient+Education+and+Counseling&rft.issn=07383991&rft_id=info:doi/10.1016%2Fj.pec.2010.11.002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Cancer; Health information; Doctor-Patient communication DO - http://dx.doi.org/10.1016/j.pec.2010.11.002 ER - TY - JOUR T1 - Active Living for Rural Children: Community Perspectives Using PhotoVOICE AN - 839571937; 201101783 AB - Background: Active living integrates physical activity into one's daily routine. Current understanding of active living among children and their families living in rural communities is limited. A community perspective is critical to understand the contextual factors that influence children's physical activity in rural areas. Purpose: The purpose of this study was to identify the perceived environmental factors that support or hinder physical activity among rural children to develop testable hypotheses to inform future interventions for reducing unhealthy weight gain and preventing chronic diseases associated with physical inactivity. Methods: PhotoVOICE was used to explore active living opportunities and barriers for children living in four low-income, rural U.S. communities. In 2007, parents (n=99) and elementary school staff (n=17) received disposable cameras to document their perspective. Using their photographs and narratives, participants developed emergent themes during a facilitated group discussion. In 2008, study authors used the Analysis Grid for Environments Linked to Obesity (ANGELO) framework to categorize the themes. Results: Microenvironment themes include physical (e.g., natural features, topography); sociocultural (e.g., isolation); policy (e.g., time for school recess); and economic (e.g., funding for physical activity programs). Macroenvironmental themes related to the built and natural environments and transportation infrastructure. Conclusions: This study identified rural environment elements that community members perceived as influencing children's physical activity patterns. Certain aspects were unique to rural areas, whereas other urban and suburban factors may be generalizable to rural settings. PhotoVOICE was a useful participatory research method to gain insight into perceived factors affecting rural children's physical activity behaviors. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Hennessy, Erin AU - Kraak, Vivica I AU - Hyatt, Raymond R AU - Bloom, Julia AU - Fenton, Mark AU - Wagoner, Colby AU - Economos, Christina D AD - National Cancer Instit, National Instits Health, Rockville, MD erin.henessy@nih.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 537 EP - 545 PB - Elsevier Science, New York NY VL - 39 IS - 6 SN - 0749-3797, 0749-3797 KW - Physical activity KW - Sedentary people KW - Rural communities KW - Children KW - Photography KW - Health promotion KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839571937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Active+Living+for+Rural+Children%3A+Community+Perspectives+Using+PhotoVOICE&rft.au=Hennessy%2C+Erin%3BKraak%2C+Vivica+I%3BHyatt%2C+Raymond+R%3BBloom%2C+Julia%3BFenton%2C+Mark%3BWagoner%2C+Colby%3BEconomos%2C+Christina+D&rft.aulast=Hennessy&rft.aufirst=Erin&rft.date=2010-12-01&rft.volume=39&rft.issue=6&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2010.09.013 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Children; Physical activity; Rural communities; Health promotion; Photography; Sedentary people DO - http://dx.doi.org/10.1016/j.amepre.2010.09.013 ER - TY - JOUR T1 - A unified set of analysis tools for uterine cervix image segmentation AN - 831172621; 13872638 AB - Segmentation is a fundamental component of many medical image-processing applications, and it has long been recognized as a challenging problem. In this paper, we report our research and development efforts on analyzing and extracting clinically meaningful regions from uterine cervix images in a large database created for the study of cervical cancer. In addition to proposing new algorithms, we also focus on developing open source tools which are in synchrony with the research objectives. These efforts have resulted in three Web-accessible tools which address three important and interrelated sub-topics in medical image segmentation, respectively: the Boundary Marking Tool (BMT), Cervigram Segmentation Tool (CST), and Multi-Observer Segmentation Evaluation System (MOSES). The BMT is for manual segmentation, typically to collect "ground truth" image regions from medical experts. The CST is for automatic segmentation, and MOSES is for segmentation evaluation. These tools are designed to be a unified set in which data can be conveniently exchanged. They have value not only for improving the reliability and accuracy of algorithms of uterine cervix image segmentation, but also promoting collaboration between biomedical experts and engineers which are crucial to medical image-processing applications. Although the CST is designed for the unique characteristics of cervigrams, the BMT and MOSES are very general and extensible, and can be easily adapted to other biomedical image collections. JF - Computerized Medical Imaging and Graphics AU - Xue, Zhiyun AU - Long, LRodney AU - Antani, Sameer AU - Neve, Leif AU - Zhu, Yaoyao AU - Thoma, George R AD - National Library of Medicine, Bethesda, MD, United States, xuez@mail.nih.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 593 EP - 604 PB - Elsevier Science, 660 White Plains Rd., Floor 2 Tarrytown NY 10591-5153 USA VL - 34 IS - 8 SN - 0895-6111, 0895-6111 KW - Biotechnology and Bioengineering Abstracts KW - Uterine cervix image KW - Image segmentation KW - Segmentation evaluation KW - Web-accessible system KW - Databases KW - Uterus KW - Data processing KW - Cervical cancer KW - Segmentation KW - Algorithms KW - Boundaries KW - Image processing KW - Uterine cancer KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/831172621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computerized+Medical+Imaging+and+Graphics&rft.atitle=A+unified+set+of+analysis+tools+for+uterine+cervix+image+segmentation&rft.au=Xue%2C+Zhiyun%3BLong%2C+LRodney%3BAntani%2C+Sameer%3BNeve%2C+Leif%3BZhu%2C+Yaoyao%3BThoma%2C+George+R&rft.aulast=Xue&rft.aufirst=Zhiyun&rft.date=2010-12-01&rft.volume=34&rft.issue=8&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Computerized+Medical+Imaging+and+Graphics&rft.issn=08956111&rft_id=info:doi/10.1016%2Fj.compmedimag.2010.04.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Databases; Uterus; Data processing; Cervical cancer; Boundaries; Algorithms; Segmentation; Image processing; Uterine cancer DO - http://dx.doi.org/10.1016/j.compmedimag.2010.04.002 ER - TY - JOUR T1 - Constitutive phosphorylation by protein kinase C regulates D1 dopamine receptor signaling. AN - 815961808; 20969574 AB - The D(1) dopamine receptor (D(1) DAR) is robustly phosphorylated by multiple protein kinases, yet the phosphorylation sites and functional consequences of these modifications are not fully understood. Here, we report that the D(1) DAR is phosphorylated by protein kinase C (PKC) in the absence of agonist stimulation. Phosphorylation of the D(1) DAR by PKC is constitutive in nature, can be induced by phorbol ester treatment or through activation of Gq-mediated signal transduction pathways, and is abolished by PKC inhibitors. We demonstrate that most, but not all, isoforms of PKC are capable of phosphorylating the receptor. To directly assess the functional role of PKC phosphorylation of the D(1) DAR, a site-directed mutagenesis approach was used to identify the PKC sites within the receptor. Five serine residues were found to mediate the PKC phosphorylation. Replacement of these residues had no effect on D(1) DAR expression or agonist-induced desensitization; however, G protein coupling and cAMP accumulation were significantly enhanced in PKC-null D(1) DAR. Thus, constitutive or heterologous PKC phosphorylation of the D(1) DAR dampens dopamine activation of the receptor, most likely occurring in a context-specific manner, mediated by the repertoire of PKC isozymes within the cell. © 2010 The Authors. Journal of Neurochemistry © 2010 International Society for Neurochemistry. JF - Journal of neurochemistry AU - Rankin, Michele L AU - Sibley, David R AD - Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-9405, USA. Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 1655 EP - 1667 VL - 115 IS - 6 KW - Receptors, Dopamine D1 KW - 0 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Phosphorylation -- physiology KW - Humans KW - HEK293 Cells KW - Molecular Sequence Data KW - Dopamine -- physiology KW - Dopamine -- metabolism KW - Mice KW - Amino Acid Sequence KW - Phosphorylation -- drug effects KW - Signal Transduction -- physiology KW - Receptors, Dopamine D1 -- physiology KW - Receptors, Dopamine D1 -- agonists KW - Protein Kinase C -- physiology KW - Receptors, Dopamine D1 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815961808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Constitutive+phosphorylation+by+protein+kinase+C+regulates+D1+dopamine+receptor+signaling.&rft.au=Rankin%2C+Michele+L%3BSibley%2C+David+R&rft.aulast=Rankin&rft.aufirst=Michele&rft.date=2010-12-01&rft.volume=115&rft.issue=6&rft.spage=1655&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=1471-4159&rft_id=info:doi/10.1111%2Fj.1471-4159.2010.07074.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-04 N1 - Date created - 2010-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Annu Rev Pharmacol Toxicol. 1998;38:289-319 [9597157] Mol Pharmacol. 2010 Jul;78(1):69-80 [20395553] Mol Pharmacol. 1999 Oct;56(4):675-83 [10496949] Neuroscience. 2000;99(2):199-203 [10938425] Mol Pharmacol. 2001 Feb;59(2):310-21 [11160868] Pharmacol Rev. 2001 Mar;53(1):1-24 [11171937] J Androl. 2002 Jan-Feb;23(1):114-20 [11783439] Mol Pharmacol. 2002 Apr;61(4):806-16 [11901220] Trends Biochem Sci. 2002 Oct;27(10):514-20 [12368087] Science. 2002 Dec 6;298(5600):1912-34 [12471243] J Neurochem. 2003 Feb;84(4):854-63 [12562528] Mol Interv. 2002 Jun;2(3):168-84 [14993377] J Biol Chem. 2004 Mar 12;279(11):10020-31 [14699102] Annu Rev Neurosci. 2004;27:107-44 [15217328] Biochem Biophys Res Commun. 1984 Jun 29;121(3):973-9 [6331437] Arch Biochem Biophys. 1986 Jan;244(1):373-81 [3484932] Nature. 1987 May 7-13;327(6117):67-70 [3033513] J Virol. 1988 Oct;62(10):3738-46 [2843671] Ann N Y Acad Sci. 1990;594:120-9 [2165756] Nature. 1990 Sep 6;347(6288):80-3 [1975640] Proc Natl Acad Sci U S A. 1990 Sep;87(17):6723-7 [2168556] J Biol Chem. 1992 Nov 5;267(31):21995-8 [1331042] J Biol Chem. 1993 Sep 25;268(27):20110-5 [8376369] J Biol Chem. 1996 Feb 16;271(7):3771-8 [8631993] Br J Pharmacol. 1996 Jul;118(6):1544-50 [8832084] Mol Pharmacol. 1996 Oct;50(4):966-76 [8863843] Hypertension. 1997 Sep;30(3 Pt 2):725-9 [9323013] J Recept Signal Transduct Res. 2004 Aug;24(3):165-205 [15521361] J Biol Chem. 2004 Nov 19;279(47):49533-41 [15347675] J Biol Chem. 2005 Feb 11;280(6):4880-7 [15561704] Mol Pharmacol. 2005 May;67(5):1414-25 [15687224] Mol Pharmacol. 2006 Mar;69(3):759-69 [16338988] Kidney Int. 2006 Sep;70(6):1072-9 [16850019] Trends Pharmacol Sci. 2008 Aug;29(8):413-20 [18606460] Curr Drug Targets. 2008 Aug;9(8):614-25 [18691009] Neuropsychopharmacology. 2008 Nov;33(12):2900-11 [18288091] Front Biosci (Landmark Ed). 2009;14:2386-99 [19273207] J Biol Chem. 2009 May 29;284(22):15038-51 [19332542] Science. 2009 Aug 21;325(5943):1017-20 [19696353] J Biol Chem. 2009 Dec 4;284(49):34103-15 [19815545] Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402 [19934406] J Biol Chem. 2010 Mar 5;285(10):7805-17 [20048153] Science. 1998 Sep 25;281(5385):2042-5 [9748166] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1471-4159.2010.07074.x ER - TY - JOUR T1 - Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence. AN - 815960521; 21057505 AB - The telomere-capping complex shelterin protects functional telomeres and prevents the initiation of unwanted DNA-damage-response pathways. At the end of cellular replicative lifespan, uncapped telomeres lose this protective mechanism and DNA-damage signalling pathways are triggered that activate p53 and thereby induce replicative senescence. Here, we identify a signalling pathway involving p53, Siah1 (a p53-inducible E3 ubiquitin ligase) and TRF2 (telomere repeat binding factor 2; a component of the shelterin complex). Endogenous Siah1 and TRF2 were upregulated and downregulated, respectively, during replicative senescence with activated p53. Experimental manipulation of p53 expression demonstrated that p53 induces Siah1 and represses TRF2 protein levels. The p53-dependent ubiquitylation and proteasomal degradation of TRF2 are attributed to the E3 ligase activity of Siah1. Knockdown of Siah1 stabilized TRF2 and delayed the onset of cellular replicative senescence, suggesting a role for Siah1 and TRF2 in p53-regulated senescence. This study reveals that p53, a downstream effector of telomere-initiated damage signalling, also functions upstream of the shelterin complex. JF - Nature cell biology AU - Fujita, Kaori AU - Horikawa, Izumi AU - Mondal, Abdul M AU - Jenkins, Lisa M Miller AU - Appella, Ettore AU - Vojtesek, Borivoj AU - Bourdon, Jean-Christophe AU - Lane, David P AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892-4258, USA. Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 1205 EP - 1212 VL - 12 IS - 12 KW - Nuclear Proteins KW - 0 KW - TP53 protein, human KW - Telomeric Repeat Binding Protein 2 KW - Tumor Suppressor Protein p53 KW - Ubiquitin-Protein Ligases KW - EC 2.3.2.27 KW - seven in absentia proteins KW - Index Medicus KW - Gene Knockdown Techniques KW - Nuclear Proteins -- genetics KW - Humans KW - Ubiquitin-Protein Ligases -- genetics KW - Ubiquitin-Protein Ligases -- metabolism KW - Nuclear Proteins -- metabolism KW - Fibroblasts KW - Telomeric Repeat Binding Protein 2 -- metabolism KW - Telomere -- metabolism KW - Cell Aging KW - Tumor Suppressor Protein p53 -- metabolism KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815960521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+cell+biology&rft.atitle=Positive+feedback+between+p53+and+TRF2+during+telomere-damage+signalling+and+cellular+senescence.&rft.au=Fujita%2C+Kaori%3BHorikawa%2C+Izumi%3BMondal%2C+Abdul+M%3BJenkins%2C+Lisa+M+Miller%3BAppella%2C+Ettore%3BVojtesek%2C+Borivoj%3BBourdon%2C+Jean-Christophe%3BLane%2C+David+P%3BHarris%2C+Curtis+C&rft.aulast=Fujita&rft.aufirst=Kaori&rft.date=2010-12-01&rft.volume=12&rft.issue=12&rft.spage=1205&rft.isbn=&rft.btitle=&rft.title=Nature+cell+biology&rft.issn=1476-4679&rft_id=info:doi/10.1038%2Fncb2123 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-06 N1 - Date created - 2010-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 2007 Jul 27;130(2):223-33 [17662938] Nat Med. 2007 Jun;13(6):742-7 [17486088] J Cell Biol. 2007 Dec 3;179(5):855-67 [18056407] Cancer Res. 2007 Dec 15;67(24):11677-86 [18089797] Mol Cell Biol. 2008 May;28(10):3538-47 [18347055] Nat Rev Cancer. 2008 Jun;8(6):450-8 [18500246] Nat Cell Biol. 2008 Jul;10(7):812-24 [18536714] Exp Gerontol. 2008 Nov;43(11):998-1004 [18817864] Cell Stem Cell. 2009 Feb 6;4(2):141-54 [19200803] Proteomics. 2009 Feb;9(4):922-34 [19180541] Nat Rev Cancer. 2009 Mar;9(3):206-16 [19180095] Nat Rev Cancer. 2009 May;9(5):371-7 [19360021] Curr Biol. 2009 May 26;19(10):874-9 [19375317] Nature. 2009 Aug 27;460(7259):1149-53 [19668189] Nat Cell Biol. 2009 Sep;11(9):1135-42 [19701195] Cell. 2009 Sep 18;138(6):1083-95 [19766563] Nat Genet. 2009 Oct;41(10):1138-43 [19718028] J Biol Chem. 2010 Apr 30;285(18):13507-16 [20181957] J Biol Chem. 2000 May 19;275(20):15578-85 [10747903] Nat Genet. 2000 Jul;25(3):347-52 [10888888] Nat Med. 2000 Aug;6(8):849-51 [10932210] Nat Cell Biol. 2000 Sep;2(9):653-60 [10980707] Mol Cell Biol. 2000 Nov;20(22):8458-67 [11046142] Mol Cell. 2001 May;7(5):915-26 [11389839] EMBO J. 2001 Oct 1;20(19):5532-40 [11574485] Science. 2002 Mar 29;295(5564):2446-9 [11923537] EMBO J. 2002 Aug 15;21(16):4338-48 [12169636] Mol Cell Biol. 2002 Dec;22(23):8155-64 [12417719] EMBO J. 2003 Mar 3;22(5):1210-22 [12606585] Nat Genet. 2003 Apr;33(4):492-6 [12652299] J Biol Chem. 2003 Apr 25;278(17):15341-8 [12588869] Genes Dev. 2003 Jun 1;17(11):1328-33 [12782650] Nature. 2003 Nov 13;426(6963):194-8 [14608368] Mol Cell. 2004 May 21;14(4):501-13 [15149599] Cancer Res. 1990 Dec 15;50(24):7979-84 [2253239] Nat Genet. 1997 Oct;17(2):236-9 [9326951] Cell. 1998 Feb 6;92(3):401-13 [9476899] Mol Cell Biol. 1999 Jan;19(1):724-32 [9858595] Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8070-3 [10393949] Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11364-9 [10500182] Nat Cell Biol. 2004 Dec;6(12):1229-35 [15531880] Curr Biol. 2004 Dec 29;14(24):2302-8 [15620660] Mol Cell Biol. 2005 Feb;25(3):1070-80 [15657433] Curr Cancer Drug Targets. 2005 Feb;5(1):57-68 [15720190] EMBO Rep. 2005 Mar;6(3):275-81 [15723042] Nature. 2005 Aug 4;436(7051):642 [16079833] Nat Rev Genet. 2005 Aug;6(8):611-22 [16136653] Genes Dev. 2005 Sep 15;19(18):2122-37 [16131611] Genes Dev. 2005 Sep 15;19(18):2100-10 [16166375] Mol Biol Cell. 2005 Oct;16(10):4623-35 [16079181] Nat Genet. 2005 Oct;37(10):1063-71 [16142233] Cell Cycle. 2006 Apr;5(7):718-21 [16582635] Mol Cell. 2006 Nov 3;24(3):355-66 [17081987] Clin Cancer Res. 2006 Nov 1;12(21):6547-56 [17085670] Cell Cycle. 2007 Jan 1;6(1):85-94 [17245126] Nat Protoc. 2006;1(6):2856-60 [17406544] EMBO Rep. 2007 May;8(5):497-503 [17396137] Cancer Cell. 2007 May;11(5):461-9 [17433785] Nature. 2007 Aug 30;448(7157):1068-71 [17687332] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/ncb2123 ER - TY - JOUR T1 - Chlamydia trachomatis and risk of prevalent and incident cervical premalignancy in a population-based cohort. AN - 815554465; 21098758 AB - Cofactors might affect the risk of the rare progression from infection with carcinogenic human papillomavirus (HPV) to cervical premalignancy to invasive cancer. Some studies have observed that Chlamydia trachomatis infection is associated with increased risk for cervical cancer. In a large prospective cohort, we assessed the role of C trachomatis in cervical premalignancy and addressed confounding by HPV. We identified 182 women with prevalent and 132 women with incident histological cervical intraepithelial neoplasia grade 2 (CIN2), grade 3 (CIN3), or cervical cancer (CIN2+) in the Costa Rica HPV Natural History Study. Control subjects were 995 (approximately 10% of the 10 049) subjects who were randomly selected from the same study. Cervical HPV status at enrollment was determined by MY09/MY11 polymerase chain reaction amplification and dot-blot hybridization. The presence of C trachomatis DNA in cervical exfoliated cells at enrollment was determined by a novel serovar-specific polymerase chain reaction-based C trachomatis detection and genotyping assay. Plasma drawn at enrollment from each subject was used to determine C trachomatis immunoglobulin G (IgG) status. Logistic regression was used to examine the association between C trachomatis and CIN2+, taking into account possible confounding by HPV. C trachomatis positivity at enrollment was associated with CIN2+ and concurrent and subsequent carcinogenic HPV infection. To account for confounding by HPV status, we restricted the analysis to women positive for carcinogenic HPV DNA at enrollment and found no association between C trachomatis status (as assessed by DNA or IgG) at enrollment and combined prevalent and/or incident CIN2+ (for C trachomatis DNA positivity, odds ratio = 0.77, 95% confidence interval = 0.42 to 1.41; for C trachomatis seropositivity, odds ratio = 1.09, 95% confidence interval = 0.85 to 1.41). We found no association between C trachomatis status, as assessed by DNA or IgG, and risk of cervical premalignancy, after controlling for carcinogenic HPV-positive status. Previous positive associations between C trachomatis and cervical premalignancy could have been caused, in part, by an increased susceptibility to HPV infection. JF - Journal of the National Cancer Institute AU - Safaeian, Mahboobeh AU - Quint, Koen AU - Schiffman, Mark AU - Rodriguez, Ana Cecilia AU - Wacholder, Sholom AU - Herrero, Rolando AU - Hildesheim, Allan AU - Viscidi, Raphael P AU - Quint, Wim AU - Burk, Robert D AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA. safaeianm@mail.nih.gov Y1 - 2010/12/01/ PY - 2010 DA - 2010 Dec 01 SP - 1794 EP - 1804 VL - 102 IS - 23 KW - DNA, Bacterial KW - 0 KW - DNA, Viral KW - Immunoglobulin A KW - Immunoglobulin G KW - Index Medicus KW - Odds Ratio KW - DNA, Bacterial -- isolation & purification KW - Humans KW - Risk Assessment KW - Immunoglobulin G -- blood KW - Genotype KW - Polymerase Chain Reaction KW - Prospective Studies KW - Logistic Models KW - Risk Factors KW - Human papillomavirus 16 KW - Adult KW - Cohort Studies KW - Confounding Factors (Epidemiology) KW - Incidence KW - Confidence Intervals KW - Enzyme-Linked Immunosorbent Assay KW - Middle Aged KW - DNA, Viral -- isolation & purification KW - Immunoglobulin A -- blood KW - United States -- epidemiology KW - Female KW - Prevalence KW - Papillomavirus Infections -- epidemiology KW - Precancerous Conditions -- microbiology KW - Uterine Cervical Neoplasms -- epidemiology KW - Papillomavirus Infections -- complications KW - Chlamydia trachomatis -- isolation & purification KW - Uterine Cervical Neoplasms -- microbiology KW - Chlamydia trachomatis -- genetics KW - Precancerous Conditions -- epidemiology KW - Chlamydia trachomatis -- immunology KW - Uterine Cervical Neoplasms -- virology KW - Chlamydia Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815554465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Chlamydia+trachomatis+and+risk+of+prevalent+and+incident+cervical+premalignancy+in+a+population-based+cohort.&rft.au=Safaeian%2C+Mahboobeh%3BQuint%2C+Koen%3BSchiffman%2C+Mark%3BRodriguez%2C+Ana+Cecilia%3BWacholder%2C+Sholom%3BHerrero%2C+Rolando%3BHildesheim%2C+Allan%3BViscidi%2C+Raphael+P%3BQuint%2C+Wim%3BBurk%2C+Robert+D&rft.aulast=Safaeian&rft.aufirst=Mahboobeh&rft.date=2010-12-01&rft.volume=102&rft.issue=23&rft.spage=1794&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/10.1093%2Fjnci%2Fdjq436 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-27 N1 - Date created - 2010-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 1999 May;80(3-4):621-4 [10408876] J Natl Cancer Inst. 1997 Sep 3;89(17):1293-9 [9293920] J Med Virol. 2002 Nov;68(3):417-23 [12226831] J Clin Microbiol. 1997 Jun;35(6):1304-10 [9163434] Int J Cancer. 2004 Sep 1;111(3):431-9 [15221973] Rev Panam Salud Publica. 2004 Feb;15(2):75-89 [15030652] Cancer Epidemiol Biomarkers Prev. 2004 Feb;13(2):324-7 [14973086] Sex Transm Infect. 2003 Dec;79(6):460-5 [14663121] Br J Cancer. 2003 Oct 6;89(7):1248-54 [14520455] Br J Cancer. 2003 Sep 1;89(5):831-3 [12942113] Sex Transm Dis. 2003 Jul;30(7):575-80 [12838087] J Pathol. 1999 Sep;189(1):12-9 [10451482] Int J Cancer. 2007 Feb 1;120(3):650-5 [17096345] J Gen Virol. 2007 Mar;88(Pt 3):814-22 [17325353] Lancet. 2007 Sep 8;370(9590):890-907 [17826171] J Mol Diagn. 2007 Nov;9(5):631-8 [17872971] J Clin Microbiol. 2007 Dec;45(12):3986-91 [17959760] J Infect Dis. 2009 Jan 1;199(1):20-30 [19012493] J Infect Dis. 2009 May 15;199(10):1449-56 [19351262] Sex Transm Dis. 2009 Nov;36(11):675-9 [19773679] J Natl Cancer Inst. 2010 Mar 3;102(5):315-24 [20157096] Int J Cancer. 2000 Jan 1;85(1):35-9 [10585579] J Natl Cancer Inst Monogr. 2003;(31):125-30 [12807956] Am J Epidemiol. 2002 Oct 15;156(8):687-92 [12370156] Rev Panam Salud Publica. 1997 May;1(5):362-75 [9180057] Int J Cancer. 2002 Oct 1;101(4):371-4 [12209962] J Infect Dis. 2002 Sep 15;186(6):737-42 [12198606] J Clin Pathol. 2002 Apr;55(4):244-65 [11919208] J Infect Dis. 2002 Feb 1;185(3):324-31 [11807714] JAMA. 2001 Apr 4;285(13):1704; author reply 1705-6 [11277820] JAMA. 2001 Jan 3;285(1):47-51 [11150108] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jnci/djq436 ER - TY - JOUR T1 - Association between hsa-mir-146a genotype and tumor age-of-onset in BRCA1/BRCA2-negative familial breast and ovarian cancer patients. AN - 815552985; 20810544 AB - An increasing body of evidence points to a possible role of microRNAs (miRNAs) in hereditary cancer syndromes. To evaluate the role of miRNA allelic variants in the susceptibility to familial breast and ovarian cancers in BRCA1/BRCA2-negative patients, we focused our attention on three miRNAs, miR-146a, miR-17 and miR-369, based on their affinity to either BRCA1 or BRCA2 messenger RNA and their localization on chromosome regions commonly deleted in those tumors. The analysis was performed on 101 Italian probands with ascertained familiarity for breast/ovarian cancer and tested negative for both BRCA1 and BRCA2 gene mutations. No allelic variant was detected for hsa-mir-17 and hsa-mir-369, and allelic and genotype frequencies for miR-146a rs2910164 single-nucleotide polymorphism (SNP) were comparable with that of 155 controls from the same population, ruling out a role for genetic variations in these three miRNAs as major determinants in cancer predisposition of BRCA1/BRCA2-negative patients. Instead, our study suggests that mir-146a rs2910164 SNP may impact on the age of cancer onset. In fact, subjects with mir-146a a GC or CC genotypes developed tumors at younger age compared with individuals with the GG genotype Thus, in contrast to a recent report, our data support the hypothesis by Shen and coworkers of an association between the C allele of hsa-mir-146a and early cancer onset and prompt further investigations on the relevance of this polymorphism in early familial breast/ovarian tumor development. JF - Carcinogenesis AU - Pastrello, Chiara AU - Polesel, Jerry AU - Della Puppa, Lara AU - Viel, Alessandra AU - Maestro, Roberta AD - Unit of Experimental Oncology 1, Department of Molecular Oncology and Translational Research, Centro di Riferimento Oncologico, CRO Aviano National Cancer Institute, 33081 Aviano, Italy. Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 2124 EP - 2126 VL - 31 IS - 12 KW - MIRN146 microRNA, human KW - 0 KW - MicroRNAs KW - Index Medicus KW - Genotype KW - Polymorphism, Single Nucleotide KW - Age of Onset KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Mutation KW - Female KW - Breast Neoplasms -- genetics KW - Ovarian Neoplasms -- genetics KW - MicroRNAs -- genetics KW - Genes, BRCA2 KW - Genes, BRCA1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815552985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Association+between+hsa-mir-146a+genotype+and+tumor+age-of-onset+in+BRCA1%2FBRCA2-negative+familial+breast+and+ovarian+cancer+patients.&rft.au=Pastrello%2C+Chiara%3BPolesel%2C+Jerry%3BDella+Puppa%2C+Lara%3BViel%2C+Alessandra%3BMaestro%2C+Roberta&rft.aulast=Pastrello&rft.aufirst=Chiara&rft.date=2010-12-01&rft.volume=31&rft.issue=12&rft.spage=2124&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgq184 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-06 N1 - Date created - 2010-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgq184 ER - TY - JOUR T1 - The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform. AN - 815552167; 20708096 AB - The US Tox21 collaborative program represents a paradigm shift in toxicity testing of chemical compounds from traditional in vivo tests to less expensive and higher throughput in vitro methods to prioritize compounds for further study, identify mechanisms of action and ultimately develop predictive models for adverse health effects in humans. The NIH Chemical Genomics Center (NCGC) is an integral component of the Tox21 collaboration owing to its quantitative high-throughput screening (qHTS) paradigm, in which titration-based screening is used to profile hundreds of thousands of compounds per week. Here, we describe the Tox21 collaboration, qHTS-based compound testing and the various Tox21 screening assays that have been validated and tested at the NCGC to date. Published by Elsevier Ltd. JF - Drug discovery today AU - Shukla, Sunita J AU - Huang, Ruili AU - Austin, Christopher P AU - Xia, Menghang AD - NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-3370, USA. Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 997 EP - 1007 VL - 15 IS - 23-24 KW - Index Medicus KW - Humans KW - Forecasting KW - Toxicity Tests -- trends KW - High-Throughput Screening Assays -- trends KW - Toxicity Tests -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815552167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+discovery+today&rft.atitle=The+future+of+toxicity+testing%3A+a+focus+on+in+vitro+methods+using+a+quantitative+high-throughput+screening+platform.&rft.au=Shukla%2C+Sunita+J%3BHuang%2C+Ruili%3BAustin%2C+Christopher+P%3BXia%2C+Menghang&rft.aulast=Shukla&rft.aufirst=Sunita&rft.date=2010-12-01&rft.volume=15&rft.issue=23-24&rft.spage=997&rft.isbn=&rft.btitle=&rft.title=Drug+discovery+today&rft.issn=1878-5832&rft_id=info:doi/10.1016%2Fj.drudis.2010.07.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-07 N1 - Date created - 2010-11-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drug Saf. 2002;25(4):263-86 [11994029] Curr Opin Chem Biol. 2010 Jun;14(3):315-24 [20417149] Nat Rev Cancer. 2003 Dec;3(12):952-9 [14737125] Sci Am. 1989 Aug;261(2):24-30 [2667132] Cell. 1995 Apr 21;81(2):299-307 [7736582] Clin Chem. 1996 Jun;42(6 Pt 1):986-7 [8665701] Mol Cell Biol. 1996 Sep;16(9):4604-13 [8756616] J Pharmacol Toxicol Methods. 2004 Nov-Dec;50(3):187-99 [15519905] Science. 2004 Nov 12;306(5699):1138-9 [15542455] Assay Drug Dev Technol. 2004 Oct;2(5):497-506 [15671647] Curr Pharm Des. 2005;11(22):2873-87 [16101443] Comb Chem High Throughput Screen. 2005 Sep;8(6):499-512 [16178809] Nat Biotechnol. 2006 Feb;24(2):167-75 [16465162] Drug Discov Today. 2006 Jan;11(1-2):43-50 [16478690] Assay Drug Dev Technol. 2006 Apr;4(2):209-21 [16712425] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Methods Enzymol. 2006;414:566-89 [17110211] Toxicol Sci. 2007 Jan;95(1):5-12 [16963515] J Med Chem. 2007 May 17;50(10):2385-90 [17447748] Science. 2008 Feb 15;319(5865):906-7 [18276874] Environ Health Perspect. 2008 Mar;116(3):284-91 [18335092] Chem Res Toxicol. 2008 Mar;21(3):659-67 [18281954] Pediatr Nephrol. 2008 May;23(5):681-94 [17955264] J Med Chem. 2008 Apr 24;51(8):2363-71 [18363325] J Med Chem. 2008 Apr 24;51(8):2372-86 [18363348] Toxicol In Vitro. 2008 Jun;22(4):1099-106 [18400464] Assay Drug Dev Technol. 2008 Oct;6(5):637-57 [19035846] Toxicol Sci. 2009 Feb;107(2):324-30 [19074763] Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2412-7 [19196967] Risk Anal. 2009 Apr;29(4):485-7; discussion 492-7 [19076321] Risk Anal. 2009 Apr;29(4):474-9 [19144067] Environ Health Perspect. 2009 May;117(5):685-95 [19479008] Assay Drug Dev Technol. 2009 Apr;7(2):143-69 [19505231] J Biomol Screen. 2009 Jun;14(5):538-46 [19483146] Assay Drug Dev Technol. 2009 Jun;7(3):233-49 [19548831] Mol Biosyst. 2009 Sep;5(9):1039-50 [19668870] Environ Health Perspect. 2009 Aug;117(8):A348-53 [19672388] Anal Biochem. 2009 Nov 1;394(1):30-8 [19583963] Toxicol Sci. 2009 Oct;111(2):202-25 [19567883] Toxicol Sci. 2009 Nov;112(1):153-63 [19502547] Toxicol Sci. 2009 Nov;112(1):1-3 [19729555] J Biomol Screen. 2009 Oct;14(9):1045-53 [19762548] Toxicol In Vitro. 2009 Dec;23(8):1576-9 [19540332] Toxicol Sci. 2009 Dec;112(2):385-93 [19805409] Curr Top Med Chem. 2009;9(13):1181-93 [19807664] Mol Cancer. 2009;8:117 [20003191] Assay Drug Dev Technol. 2009 Dec;7(6):606-14 [20059377] Biochem Pharmacol. 2010 May 1;79(9):1272-80 [20067776] Nat Rev Drug Discov. 2003 Jul;2(7):542-53 [12815380] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.drudis.2010.07.007 ER - TY - JOUR T1 - On the roles of Mg in the activation of G proteins. AN - 814463477; 20731539 AB - In this review, we highlight the evolution of our knowledge about the way Mg(2+) participates in the activation of heterotrimeric G proteins, beginning with its requirement in hormonal stimulation of fat cell adenylyl cyclase (1969) and ending with knowledge that incorporates information obtained from site directed mutagenesis and examination of the crystal structures of G proteins (2010). Our current view is that, as it seeks to fill its octahedral coordination shell, Mg acts as a keystone locking the G protein-α subunits into a conformation in which Gα dissociates from the Gβγ dimer, is competent in regulating effectors, and acquires GTPase activity. The latter is the result of moving the backbone carbonyl group of the Mg-coordinating threonine into a location in space that positions the hydrolytic water so as to facilitate the water's nucleophilic attack that leads to hydrolysis of the link between the β and γ phosphates of guanosine triphosphate (GTP). The role of the backbone carbonyl group of the Mg-coordinating threonine is equi-hierarchical with a similar and long-recognized role of the Switch II glutamine δ amide carbonyl group. Disruption of either leads to loss of GTPase activity. JF - Journal of receptor and signal transduction research AU - Birnbaumer, Lutz AU - Zurita, Adolfo R AD - Laboratory of Neurobiology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC27709, USA. birnbau1@niehs.nih.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 372 EP - 375 VL - 30 IS - 6 KW - Protein Subunits KW - 0 KW - Guanosine Triphosphate KW - 86-01-1 KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Magnesium KW - I38ZP9992A KW - Index Medicus KW - Molecular Structure KW - Second Messenger Systems KW - Protein Subunits -- genetics KW - Enzyme Activation KW - Adenylyl Cyclases -- metabolism KW - Protein Subunits -- metabolism KW - Protein Subunits -- chemistry KW - Guanosine Triphosphate -- metabolism KW - Magnesium -- metabolism KW - GTP-Binding Proteins -- metabolism KW - GTP-Binding Proteins -- chemistry KW - GTP-Binding Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/814463477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+receptor+and+signal+transduction+research&rft.atitle=On+the+roles+of+Mg+in+the+activation+of+G+proteins.&rft.au=Birnbaumer%2C+Lutz%3BZurita%2C+Adolfo+R&rft.aulast=Birnbaumer&rft.aufirst=Lutz&rft.date=2010-12-01&rft.volume=30&rft.issue=6&rft.spage=372&rft.isbn=&rft.btitle=&rft.title=Journal+of+receptor+and+signal+transduction+research&rft.issn=1532-4281&rft_id=info:doi/10.3109%2F10799893.2010.508165 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-28 N1 - Date created - 2010-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1969 Jul 10;244(13):3468-76 [4307452] Proc Natl Acad Sci U S A. 1982 Sep;79(17):5179-83 [6291028] Proc Natl Acad Sci U S A. 2010 May 25;107(21):9596-601 [20457940] Biochim Biophys Acta. 2007 Apr;1768(4):756-71 [17141178] Biochim Biophys Acta. 2007 Apr;1768(4):772-93 [17258171] Biochemistry. 1997 Dec 16;36(50):15660-9 [9398294] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/10799893.2010.508165 ER - TY - JOUR T1 - Gaucher disease and parkinsonism, a molecular link theory. AN - 812134167; 20801700 AB - Mutant GBA was found recently to be the most prevalent risk factor for familial parkinsonism. The two diseases do not share common symptoms and there is no direct pathway to explain the mechanism by which GBA mutations can confer the risk. Increased burden on the degradative pathway caused by defective glucocerebrosidase, or toxic side effects of glycosylated lipids accumulation were proposed to explain brain damage. Both hypotheses are not sufficient to explain the linkage. In order to develop a more inclusive theory we introduced into the model the prion theory and the second hit. Other possibilities are also brought into consideration. Copyright © 2010 Elsevier Inc. All rights reserved. JF - Molecular genetics and metabolism AU - Goldin, Ehud AD - Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-3708, USA. goldine@mail.nih.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 307 EP - 310 VL - 101 IS - 4 KW - Glucosylceramidase KW - EC 3.2.1.45 KW - Index Medicus KW - Animals KW - Glucosylceramidase -- metabolism KW - Humans KW - Glucosylceramidase -- genetics KW - Mutation KW - Gaucher Disease -- genetics KW - Gaucher Disease -- enzymology KW - Parkinsonian Disorders -- enzymology KW - Parkinsonian Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/812134167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+genetics+and+metabolism&rft.atitle=Gaucher+disease+and+parkinsonism%2C+a+molecular+link+theory.&rft.au=Goldin%2C+Ehud&rft.aulast=Goldin&rft.aufirst=Ehud&rft.date=2010-12-01&rft.volume=101&rft.issue=4&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Molecular+genetics+and+metabolism&rft.issn=1096-7206&rft_id=info:doi/10.1016%2Fj.ymgme.2010.08.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-17 N1 - Date created - 2010-11-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Annu Rev Microbiol. 1999;53:283-314 [10547693] Trends Neurosci. 2010 Jul;33(7):317-25 [20493564] Trends Mol Med. 2001 Apr;7(4):151-6 [11286938] Neuron. 2002 Dec 19;36(6):1007-19 [12495618] Mol Genet Metab. 2004 Jul;82(3):192-207 [15234332] Science. 2004 Aug 27;305(5688):1292-5 [15333840] Mol Genet Metab. 2004 Sep-Oct;83(1-2):6-15 [15464415] Dev Biol Stand. 1991;75:55-74 [1686599] Neurobiol Dis. 2005 Feb;18(1):83-8 [15649698] J Inherit Metab Dis. 2004;27(5):649-58 [15669681] Int J Biochem Cell Biol. 2005 Nov;37(11):2310-20 [15982918] J Biol Chem. 2007 Nov 9;282(45):32655-64 [17848577] Am J Epidemiol. 2008 Jan 1;167(1):90-5 [17890755] Neurodegener Dis. 2008;5(2):55-9 [18182779] Hum Mutat. 2008 May;29(5):567-83 [18338393] Nat Med. 2008 May;14(5):504-6 [18391962] Neurology. 2008 Jun 10;70(24):2277-83 [18434642] Biophys J. 2009 Apr 8;96(7):2857-70 [19348768] Eur J Neurol. 2009 Mar;16(3):297-309 [19364361] Lancet. 2009 Jun 13;373(9680):2055-66 [19524782] Mol Genet Metab. 2009 Sep-Oct;98(1-2):152-65 [19647672] Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13010-5 [19651612] Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12571-2 [19666621] PLoS One. 2009;4(10):e7227 [19806188] N Engl J Med. 2009 Oct 22;361(17):1651-61 [19846850] Curr Protein Pept Sci. 2009 Oct;10(5):483-99 [19538146] Brain. 2010 Jan;133(Pt 1):172-88 [19903734] Cell Tissue Res. 2009 Dec;338(3):343-54 [19834742] J Cell Sci. 2010 Apr 15;123(Pt 8):1191-201 [20356930] Biophys J. 2010 Jun 2;98(11):2722-30 [20513417] Clin Chem. 2000 Feb;46(2):167-74 [10657372] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ymgme.2010.08.004 ER - TY - JOUR T1 - Identification of specific determinants of human APOBEC3F, APOBEC3C, and APOBEC3DE and African green monkey APOBEC3F that interact with HIV-1 Vif. AN - 812132393; 20943965 AB - Human APOBEC3F (hA3F) and human APOBEC3G (hA3G) are potent anti-human immunodeficiency virus (anti-HIV) host factors that suppress viral replication by hypermutating the viral genome, inhibiting reverse transcription, and hindering integration. To overcome hA3F and hA3G, HIV-1 encodes Vif, which binds and targets these host proteins for proteasomal degradation. Previously, we reported that the hA3F-Vif interactions that lead to hA3F degradation are located in the region comprising amino acids 283 to 300. We have now performed mutational analysis of this region and found that the (289)EFLARH(294) amino acids contribute to hA3F-Vif binding and are critical for A3F's sensitivity to Vif. Mutants in which E289 is mutated significantly increase hA3F's ability to inhibit viral infectivity in the presence of Vif, and coimmunoprecipitation assays show that binding of Vif to the E289K mutant is decreased. We examined the role of the EFLARH sequence in other A3 proteins, including human A3C (hA3C), human A3DE (hA3DE), African green monkey A3F (agmA3F), and rhesus macaque A3F (rhA3F). hA3C, hA3DE, and agmA3F were all susceptible to degradation induced by HIV-1 Vif, while rhA3F was not. Mutagenesis of the glutamate in the EFLARH sites of hA3C, hA3DE, and agmA3F decreases the susceptibilities of these proteins to Vif-induced degradation. Together, these results indicate that the EFLARH region in hA3F, hA3C, hA3DE, and agmA3F interacts with HIV-1 Vif and that this interaction plays a role in the Vif-mediated proteasomal degradation of these A3 proteins. These studies identify a conserved region in 3 of 7 human A3 proteins that is critical for degradation mediated by HIV-1 Vif and provide structural insights into the hA3F-Vif interactions that could facilitate the development of a novel class of anti-HIV agents. JF - Journal of virology AU - Smith, Jessica L AU - Pathak, Vinay K AD - Viral Mutation Section, HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702-1201, USA. Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 12599 EP - 12608 VL - 84 IS - 24 KW - vif Gene Products, Human Immunodeficiency Virus KW - 0 KW - APOBEC3 protein, human KW - EC 3.5.4.1 KW - Cytosine Deaminase KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Animals KW - Kidney -- metabolism KW - Humans KW - Cercopithecus aethiops KW - Molecular Sequence Data KW - Kidney -- cytology KW - Immunoprecipitation KW - Mutation -- genetics KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Protein Binding KW - Cell Line KW - Kidney -- virology KW - Virus Replication KW - vif Gene Products, Human Immunodeficiency Virus -- genetics KW - Cytosine Deaminase -- genetics KW - vif Gene Products, Human Immunodeficiency Virus -- metabolism KW - Cytosine Deaminase -- metabolism KW - HIV-1 -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/812132393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Identification+of+specific+determinants+of+human+APOBEC3F%2C+APOBEC3C%2C+and+APOBEC3DE+and+African+green+monkey+APOBEC3F+that+interact+with+HIV-1+Vif.&rft.au=Smith%2C+Jessica+L%3BPathak%2C+Vinay+K&rft.aulast=Smith&rft.aufirst=Jessica&rft.date=2010-12-01&rft.volume=84&rft.issue=24&rft.spage=12599&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.01437-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-06 N1 - Date created - 2010-11-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2003 Jul 3;424(6944):99-103 [12808466] Mol Cell. 2003 Sep;12(3):591-601 [14527406] Nat Med. 2003 Nov;9(11):1404-7 [14528300] Nat Med. 2003 Nov;9(11):1398-403 [14528301] Science. 2003 Nov 7;302(5647):1056-60 [14564014] Hum Gene Ther. 1999 Jan 1;10(1):123-32 [10022537] J Exp Med. 1999 Jun 7;189(11):1735-46 [10359577] Genes Dev. 2004 Dec 1;18(23):2861-6 [15574592] Genes Dev. 2004 Dec 1;18(23):2867-72 [15574593] J Biol Chem. 2004 Dec 17;279(51):53379-86 [15466872] Curr Biol. 2005 Jan 26;15(2):166-70 [15668174] J Virol. 2005 Aug;79(15):9579-87 [16014920] Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11444-9 [16076960] J Virol. 2006 Mar;80(6):3112-5 [16501124] Virology. 2006 May 25;349(1):31-40 [16460778] Curr Biol. 2003 Nov 11;13(22):2009-13 [14614829] J Biol Chem. 2004 Feb 27;279(9):7792-8 [14672928] Virology. 2004 Feb 20;319(2):163-75 [15015498] Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3927-32 [14978281] Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3770-4 [14999100] J Biol Chem. 2004 Apr 9;279(15):14481-3 [14966139] Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5652-7 [15054139] Nat Struct Mol Biol. 2004 May;11(5):435-42 [15098018] Nucleic Acids Res. 2004;32(8):2421-9 [15121899] Methods Cell Biol. 1994;43 Pt A:99-112 [7823872] J Biol Chem. 2006 Jun 23;281(25):17259-65 [16636053] J Virol. 2006 Nov;80(21):10522-33 [16920826] J Virol. 2006 Dec;80(23):11710-22 [16971427] J Biol Chem. 2007 Jan 26;282(4):2587-95 [17121840] J Virol. 2007 Apr;81(8):3807-15 [17267497] J Virol. 2007 Jul;81(13):7238-48 [17428847] J Virol. 2007 Jul;81(13):7099-110 [17428871] Virology. 2007 Aug 15;365(1):92-100 [17459442] J Virol. 2007 Aug;81(15):8201-10 [17522216] J Virol. 2007 Oct;81(20):11322-31 [17670826] J Biol Chem. 2007 Nov 2;282(44):32065-74 [17855362] J Virol. 2007 Dec;81(23):13235-41 [17898068] J Virol. 2007 Dec;81(24):13932-7 [17942564] Nucleic Acids Res. 2007;35(21):7096-108 [17942420] Virology. 2008 May 25;375(1):1-12 [18308358] J Mol Biol. 2008 Sep 12;381(4):1000-11 [18619467] Cell Microbiol. 2008 Aug;10(8):1662-75 [18419775] Microbes Infect. 2008 Aug-Sep;10(10-11):1142-9 [18603011] PLoS Pathog. 2008 Dec;4(12):e1000231 [19057663] PLoS One. 2008;3(12):e3963 [19088851] J Virol. 2009 Feb;83(4):1992-2003 [19036809] J Virol. 2009 Mar;83(5):2374-81 [19109396] J Mol Biol. 2009 Jun 26;389(5):819-32 [19389408] J Virol. 2009 Sep;83(17):8544-52 [19535447] J Virol. 2009 Sep;83(17):8674-82 [19535450] Trends Pharmacol Sci. 2009 Dec;30(12):638-46 [19837465] J Virol. 2010 Jan;84(1):88-95 [19828612] J Virol. 2010 Feb;84(4):1902-11 [19939923] J Virol. 2010 May;84(10):5250-9 [20219927] J Virol. 2010 Jun;84(11):5741-50 [20335268] PLoS Pathog. 2010;6(6):e1000925 [20532212] J Virol. 2010 Sep;84(17):8561-70 [20592083] J Biol Chem. 2010 Sep 17;285(38):29326-35 [20624919] Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7297-301 [7638184] J Virol. 2004 Jun;78(11):6073-6 [15141007] EMBO J. 2004 Jun 16;23(12):2451-8 [15152192] Curr Biol. 2004 Aug 10;14(15):1385-91 [15296757] J Virol. 1994 Feb;68(2):704-12 [8289374] J Virol. 2000 Sep;74(18):8358-67 [10954535] Antimicrob Agents Chemother. 2002 Jun;46(6):1896-905 [12019106] Nature. 2002 Aug 8;418(6898):646-50 [12167863] Science. 2003 May 16;300(5622):1112 [12750511] Cell. 2003 Jun 13;113(6):803-9 [12809610] Nature. 2003 Jul 3;424(6944):94-8 [12808465] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.01437-10 ER - TY - JOUR T1 - Adult ovarian function can be affected by high levels of soy. AN - 812130612; 20980642 AB - Ovarian function in adults is controlled by hormones circulating in the body. The primary hormone responsible for cyclicity in animals and humans is estrogen. Estrogen is mostly produced in the ovary and enters the circulation where it then signals the brain for a response. The parts of the brain that controls reproductive hormones are the hypothalamus and anterior pituitary. Estrogen stimulates the hypothalamus to produce gonadotropin releasing hormone, which in turn signals the anterior pituitary to produce follicle stimulating hormone and luteinizing hormone. These hormones enter the circulation and signal the ovary to ovulate. Substances with estrogenic activity can potentially interfere with this signaling if levels of activity are sufficient to cause a response. Soy foods contain estrogenic substances called phytoestrogens. The predominant phytoestrogens found in soy are genistein and daidzein. The female reproductive system is dependent on hormones for proper function and phytoestrogens at very high levels can interfere with this process. This paper summarizes the literature on adult soy consumption and its effect on ovarian function. JF - The Journal of nutrition AU - Jefferson, Wendy N AD - Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. jeffers1@niehs.nih.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 2322S EP - 2325S VL - 140 IS - 12 KW - Estrogens KW - 0 KW - Soybean Proteins KW - Index Medicus KW - Humans KW - Estrogens -- biosynthesis KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/812130612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutrition&rft.atitle=Adult+ovarian+function+can+be+affected+by+high+levels+of+soy.&rft.au=Jefferson%2C+Wendy+N&rft.aulast=Jefferson&rft.aufirst=Wendy&rft.date=2010-12-01&rft.volume=140&rft.issue=12&rft.spage=2322S&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutrition&rft.issn=1541-6100&rft_id=info:doi/10.3945%2Fjn.110.123802 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-30 N1 - Date created - 2010-11-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Complement Ther Clin Pract. 2008 May;14(2):132-5 [18396257] Aust J Exp Biol Med Sci. 1951 Jul;29(4):273-9 [14886264] J Steroid Biochem Mol Biol. 2000 May;73(1-2):1-10 [10822019] Br J Cancer. 2000 Jun;82(11):1879-86 [10839307] J AOAC Int. 2000 May-Jun;83(3):635-50 [10868587] Breast Cancer Res. 2000;2(5):345-52 [11250727] J Nutr. 2002 Mar;132(3):570S-573S [11880595] J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Sep 25;777(1-2):179-89 [12270211] Maturitas. 2003 Aug 20;45(4):241-6 [12927310] J Nutr. 2004 Nov;134(11):3089-94 [15514280] J Reprod Fertil. 1972 Jan;28(1):160-1 [5008001] Gastroenterology. 1987 Aug;93(2):225-33 [3297906] BMJ. 1990 Oct 20;301(6757):905-6 [2124510] J Nutr. 1995 Mar;125(3 Suppl):771S-776S [7884563] J Clin Endocrinol Metab. 1995 May;80(5):1685-90 [7745019] Food Chem Toxicol. 1996 May;34(5):457-61 [8655094] Nutr Cancer. 1996;26(2):123-48 [8875551] Endocrinology. 1997 Nov;138(11):4613-21 [9348186] Steroids. 1998 Jan;63(1):14-20 [9437790] Environ Health Perspect. 1998 Jul;106(7):369-73 [9637793] Endocrinology. 1998 Oct;139(10):4252-63 [9751507] J Natl Cancer Inst. 1998 Dec 2;90(23):1830-5 [9839524] J Clin Endocrinol Metab. 1999 Jan;84(1):192-7 [9920082] Am J Obstet Gynecol. 1999 Mar;180(3 Pt 1):737-43 [10076156] Aust J Exp Biol Med Sci. 1951 Jul;29(4):249-53 [14886261] Hum Reprod Update. 2009 Jul-Aug;15(4):423-40 [19299447] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3945/jn.110.123802 ER - TY - JOUR T1 - Lysine 63-linked ubiquitination is important for arachidonic acid-induced cellular adhesion and migration. AN - 812126187; 21102657 AB - Arachidonic acid, a dietary cis-polyunsaturated fatty acid, stimulates adhesion and migration of human cancer cells on the extracellular matrix by activation of intracellular signaling pathways. Polyubiquitin chains bearing linkages through different lysine residues convey distinct structural and functional information that is important for signal transduction. We investigated whether ubiquitination was required for arachidonic acid-induced cellular adhesion and migration of MDA-MB-435 cells on collagen type IV. An E1 (ubiquitin-activating enzyme) inhibitor, PYR-431, completely abrogated arachidonic acid-stimulated adhesion. Additionally, expression of a lysine null mutant ubiquitin prevented activation of cellular adhesion. Cells expressing ubiquitin in which lysine 63 (K63) was mutated to arginine (K63R) were unable to adhere to collagen upon exposure to arachidonic acid. When K63 was the only lysine present, the cells retained the ability to adhere, indicating that K63-linked ubiquitin is both necessary and sufficient. Moreover, K63-linked ubiquitin was required for the induction of cell migration by arachidonic acid. The ubiquitin mutants and PYR-431 did not prevent arachidonic acid-induced phosphorylation of TGF-β activated kinase-1 (TAK1) and p38 MAPK, suggesting K63-linked ubiquitination occurs downstream of MAPK. These novel findings are the first to demonstrate a role for K63-linked ubiquitination in promoting cell adhesion and migration. JF - Biochemistry and cell biology = Biochimie et biologie cellulaire AU - Ray, Denise M AU - Rogers, Brian A AU - Sunman, Jeffrey A AU - Akiyama, Steven K AU - Olden, Kenneth AU - Roberts, John D AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 947 EP - 956 VL - 88 IS - 6 KW - Collagen Type IV KW - 0 KW - Enzyme Inhibitors KW - Ubiquitin KW - Arachidonic Acid KW - 27YG812J1I KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Ubiquitin-Activating Enzymes KW - EC 6.2.1.45 KW - UBE1 protein, human KW - EC 6.3.2.19 KW - Lysine KW - K3Z4F929H6 KW - Index Medicus KW - Ubiquitin-Activating Enzymes -- metabolism KW - Extracellular Matrix -- metabolism KW - Phosphorylation KW - Humans KW - Ubiquitination KW - Neoplasm Metastasis KW - Enzyme Inhibitors -- pharmacology KW - Cell Line, Tumor KW - p38 Mitogen-Activated Protein Kinases -- metabolism KW - Ubiquitin -- metabolism KW - Ubiquitin -- genetics KW - Breast Neoplasms -- pathology KW - Arachidonic Acid -- pharmacology KW - Cell Movement -- drug effects KW - Breast Neoplasms -- metabolism KW - Cell Adhesion -- drug effects KW - Arachidonic Acid -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/812126187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+and+cell+biology+%3D+Biochimie+et+biologie+cellulaire&rft.atitle=Lysine+63-linked+ubiquitination+is+important+for+arachidonic+acid-induced+cellular+adhesion+and+migration.&rft.au=Ray%2C+Denise+M%3BRogers%2C+Brian+A%3BSunman%2C+Jeffrey+A%3BAkiyama%2C+Steven+K%3BOlden%2C+Kenneth%3BRoberts%2C+John+D&rft.aulast=Ray&rft.aufirst=Denise&rft.date=2010-12-01&rft.volume=88&rft.issue=6&rft.spage=947&rft.isbn=&rft.btitle=&rft.title=Biochemistry+and+cell+biology+%3D+Biochimie+et+biologie+cellulaire&rft.issn=1208-6002&rft_id=info:doi/10.1139%2FO10-148 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-16 N1 - Date created - 2010-11-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2001 Mar 15;61(6):2445-52 [11289113] Mol Cancer Res. 2010 May;8(5):629-42 [20460404] Methods Cell Biol. 2002;69:281-96 [12070999] J Biol Chem. 2003 Apr 25;278(17):15429-34 [12591926] Mol Cell Biol. 2003 Aug;23(15):5331-45 [12861019] Mol Cell. 2004 Aug 27;15(4):535-48 [15327770] J Biol Chem. 1983 Jul 10;258(13):8206-14 [6305978] J Cell Biol. 1989 Aug;109(2):863-75 [2527241] Nutr Rev. 1990 Jan;48(1):6-14 [2186315] EMBO J. 1990 Sep;9(9):2923-9 [2390975] EMBO J. 1991 Jan;10(1):227-36 [1989885] Br J Cancer. 1995 Apr;71(4):744-52 [7710939] Adv Exp Med Biol. 1994;364:83-91 [7725962] Nutr Cancer. 1995;24(1):57-66 [7491298] Cancer Res. 1996 May 1;56(9):2206-12 [8616873] J Biol Chem. 2000 Apr 14;275(15):11284-90 [10753939] Breast Cancer Res Treat. 1997 Nov-Dec;46(2-3):225-37 [9478277] Annu Rev Biochem. 1998;67:425-79 [9759494] Biochim Biophys Acta. 2004 Nov 29;1695(1-3):55-72 [15571809] J Cell Sci. 2005 Mar 15;118(Pt 6):1223-32 [15728256] Genes Cells. 2005 May;10(5):447-54 [15836773] Nat Rev Mol Cell Biol. 2005 Aug;6(8):599-609 [16064136] J Biol Chem. 2005 Sep 9;280(36):31413-9 [16000313] Nat Immunol. 2006 Sep;7(9):962-70 [16862162] Curr Top Med Chem. 2007;7(3):311-40 [17305573] Circ Res. 2007 May 11;100(9):1276-91 [17495234] Nature. 2007 Jun 28;447(7148):1135-8 [17597759] Cancer Res. 2007 Oct 1;67(19):9472-81 [17909057] Hum Mol Genet. 2008 Feb 1;17(3):431-9 [17981811] Cancer Res. 2008 Mar 15;68(6):1741-50 [18339854] Nat Cell Biol. 2008 Oct;10(10):1199-207 [18758450] Cancer Res. 2009 Feb 1;69(3):735-40 [19155312] Nat Cell Biol. 2009 May;11(5):624-30 [19363486] J Biol Chem. 2009 Jul 31;284(31):20936-45 [19506078] Science. 2009 Aug 28;325(5944):1134-8 [19713527] J Biol Chem. 2010 Feb 19;285(8):5347-60 [20038579] Nat Biotechnol. 2010 Mar;28(3):214-29 [20212481] Nature. 2001 Jul 19;412(6844):346-51 [11460167] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1139/O10-148 ER - TY - JOUR T1 - Molecular classification of an elasmobranch angiotensin receptor: Quantification of angiotensin receptor and natriuretic peptide receptor mRNAs in saltwater and freshwater populations of the Atlantic stingray AN - 807293298; 13871836 AB - Among the most conserved osmoregulatory hormone systems in vertebrates are the renin-angiotensin system (RAS) and the natriuretic peptides (NPs). We examined the RAS and NP system in the euryhaline Atlantic stingray, Dasyatis sabina (Lesueur). To determine the relative sensitivity of target organs to these hormonal systems, we isolated cDNA sequences encoding the D. sabina angiotensin receptor (AT) and natriuretic peptide type-B receptor (NPR-B). We then determined the tissue-specific expression of their mRNAs in saltwater D. sabina from local Texas waters and an isolated freshwater population in Lake Monroe, Florida. AT mRNA was most abundant in interrenal tissue from both populations. NPR-B mRNA was most abundant in rectal gland tissue from both populations, and also highly abundant in the kidney of saltwater D. sabina. This study is the first to report the sequence of an elasmobranch angiotensin receptor, and phylogenetic analysis indicates that the D. sabina receptor is more similar to AT sub(1) vs. AT sub(2) proteins. This classification is further supported by molecular analysis of AT sub(1) and AT sub(2) proteins demonstrating conservation of AT sub(1)-specific amino acid residues and motifs in D. sabina AT. Molecular classification of the elasmobranch angiotensin receptor as an AT sub(1)-like protein provides fundamental insight into the evolution of the vertebrate RAS. JF - Comparative Biochemistry and Physiology, Part B: Biochemistry and Molecular Biology AU - Evans, Andrew N AU - Henning, Toni AU - Gelsleichter, James AU - Nunez, BScott AD - The University of Texas Marine Science Institute, Port Aransas, Texas 78373, USA, evansan@mail.nih.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 423 EP - 431 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 157 IS - 4 SN - 1096-4959, 1096-4959 KW - Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Angiotensin receptor KW - Elasmobranch KW - Natriuretic peptides KW - Natriuretic peptide receptor KW - Osmoregulation KW - Renin-angiotensin system KW - Biochemistry KW - Nucleotide sequence KW - Dasyatis sabina KW - ASW, USA, Texas KW - Lakes KW - Classification KW - Glands KW - Populations KW - ASW, USA, Florida KW - Amino Acids KW - USA, Florida, Monroe L. KW - Receptors KW - Kidneys KW - A, Atlantic KW - Dasyatidae KW - RAS KW - Proteins KW - Conservation KW - Peptides KW - Elasmobranchii KW - Evolution KW - Amino acid sequence KW - Q1 08443:Population genetics KW - SW 0850:Lakes KW - Q5 08502:Methods and instruments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807293298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comparative+Biochemistry+and+Physiology%2C+Part+B%3A+Biochemistry+and+Molecular+Biology&rft.atitle=Molecular+classification+of+an+elasmobranch+angiotensin+receptor%3A+Quantification+of+angiotensin+receptor+and+natriuretic+peptide+receptor+mRNAs+in+saltwater+and+freshwater+populations+of+the+Atlantic+stingray&rft.au=Evans%2C+Andrew+N%3BHenning%2C+Toni%3BGelsleichter%2C+James%3BNunez%2C+BScott&rft.aulast=Evans&rft.aufirst=Andrew&rft.date=2010-12-01&rft.volume=157&rft.issue=4&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Comparative+Biochemistry+and+Physiology%2C+Part+B%3A+Biochemistry+and+Molecular+Biology&rft.issn=10964959&rft_id=info:doi/10.1016%2Fj.cbpb.2010.09.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Classification; Glands; Nucleotide sequence; Receptors; Peptides; Evolution; RAS; Amino acid sequence; Amino Acids; Lakes; Biochemistry; Conservation; Proteins; Kidneys; Populations; Elasmobranchii; Dasyatidae; Dasyatis sabina; ASW, USA, Texas; ASW, USA, Florida; USA, Florida, Monroe L.; A, Atlantic DO - http://dx.doi.org/10.1016/j.cbpb.2010.09.006 ER - TY - JOUR T1 - Ex3αERKO male infertility phenotype recapitulates the αERKO male phenotype. AN - 787047078; 20833731 AB - Disruption of the Esr1 gene encoding estrogen receptor α (ERα) by insertion of a neomycin resistance gene (neo) into exon 2 (αERKO mice) was shown previously to cause infertility in male mice. While full-length ERα protein was not expressed in αERKO mice, alternative splicing resulted in the low-level expression of a truncated form lacking the N-terminus A/B domain and containing the DNA- and ligand-binding domains. Thus, it was unclear whether the reproductive phenotype in αERKO males was only due to the lack of full-length ERα or was affected by the presence of the variant ERα isoform. The present study examined male mice with deletion of exon 3 of Esr1 gene, lacking the DNA-binding domain, and null for ERα (Ex3αERKO). Dilation of some seminiferous tubules was apparent in male Ex3αERKO mice as early as postnatal day 10 and was pronounced in all tubules from day 20 onward. At 6 weeks of age, sperm numbers and sperm motility were lower in Ex3αERKO mice than in wild-type (WT) mice, and the rete testis and efferent ductules were dilated. Mating studies determined that adult Ex3αERKO males were infertile and failed to produce copulatory plugs. Serum testosterone levels and Hsd17b3 and Cyp17a1 transcript levels were significantly higher, but serum estradiol, progesterone, LH, and FSH levels and Cyp19a1 transcript levels were not significantly different from those in WT mice. These results confirm and extend those seen in other studies on male mice with deletion of exon 3 of Esr1 gene. In addition, the reproductive phenotype of male Ex3αERKO mice recapitulated the phenotype of αERKO mice, strongly suggesting that the αERKO male infertility was not due to the presence of the DNA-binding domain in the truncated form of ERα and that full-length ERα is essential for maintenance of male fertility. JF - The Journal of endocrinology AU - Goulding, Eugenia H AU - Hewitt, Sylvia C AU - Nakamura, Noriko AU - Hamilton, Katherine AU - Korach, Kenneth S AU - Eddy, Edward M AD - Gamete Biology Group, Laboratory of Reproduction and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 281 EP - 288 VL - 207 IS - 3 KW - Estrogen Receptor alpha KW - 0 KW - Testosterone KW - 3XMK78S47O KW - Progesterone KW - 4G7DS2Q64Y KW - Estradiol KW - 4TI98Z838E KW - Luteinizing Hormone KW - 9002-67-9 KW - Follicle Stimulating Hormone KW - 9002-68-0 KW - 17-Hydroxysteroid Dehydrogenases KW - EC 1.1.- KW - Steroid 17-alpha-Hydroxylase KW - EC 1.14.14.19 KW - Index Medicus KW - Animals KW - 17-Hydroxysteroid Dehydrogenases -- metabolism KW - Epididymis KW - Testosterone -- genetics KW - Mice KW - Estradiol -- genetics KW - Follicle Stimulating Hormone -- blood KW - Exons -- genetics KW - Phenotype KW - Rete Testis KW - Estradiol -- blood KW - Sperm Count KW - Steroid 17-alpha-Hydroxylase -- metabolism KW - Testosterone -- blood KW - Mice, Inbred C57BL KW - Luteinizing Hormone -- blood KW - Seminiferous Tubules KW - Progesterone -- blood KW - Male KW - Sperm Motility -- genetics KW - Sequence Deletion KW - Estrogen Receptor alpha -- genetics KW - Infertility, Male -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/787047078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+endocrinology&rft.atitle=Ex3%CE%B1ERKO+male+infertility+phenotype+recapitulates+the+%CE%B1ERKO+male+phenotype.&rft.au=Goulding%2C+Eugenia+H%3BHewitt%2C+Sylvia+C%3BNakamura%2C+Noriko%3BHamilton%2C+Katherine%3BKorach%2C+Kenneth+S%3BEddy%2C+Edward+M&rft.aulast=Goulding&rft.aufirst=Eugenia&rft.date=2010-12-01&rft.volume=207&rft.issue=3&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+endocrinology&rft.issn=1479-6805&rft_id=info:doi/10.1677%2FJOE-10-0290 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-13 N1 - Date created - 2010-11-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Endocrinology. 2000 Mar;141(3):1273-6 [10698205] Endocrinology. 2008 Jun;149(6):2970-9 [18339713] Mol Cell Endocrinol. 2001 Jun 10;178(1-2):57-63 [11403895] J Androl. 2001 Sep-Oct;22(5):825-30 [11545296] Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2205-10 [11854517] Mol Endocrinol. 2002 Oct;16(10):2188-201 [12351685] Nucleic Acids Res. 2001 May 1;29(9):e45 [11328886] Endocrinology. 2003 Jan;144(1):84-93 [12488333] Mol Endocrinol. 2003 Jun;17(6):1039-53 [12624116] Endocrinology. 2008 Oct;149(10):5043-51 [18566133] Endocrinology. 2008 Dec;149(12):6198-206 [18719025] Endocrinology. 2009 Jan;150(1):251-9 [18755802] Mol Cell Biochem. 2009 Jan;321(1-2):145-53 [18953638] Endocrinology. 2009 Jun;150(6):2865-72 [19196801] Endocrinology. 2009 Jun;150(6):2898-905 [19264877] J Anat. 2009 Jun;214(6):916-25 [19538635] Biol Reprod. 2010 May;82(5):948-57 [20130267] FASEB J. 2010 Dec;24(12):4660-7 [20667977] Endocrinology. 2004 May;145(5):2487-97 [14749355] Histochemistry. 1984;81(2):139-47 [6490402] Aust J Biol Sci. 1987;40(1):79-90 [3509051] J Androl. 1990 Mar-Apr;11(2):140-54 [2324001] Biol Reprod. 1990 Mar;42(3):533-8 [2340336] Endocrinology. 1991 Jun;128(6):2874-9 [2036967] Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11162-6 [8248223] Mol Endocrinol. 1995 Nov;9(11):1441-54 [8584021] Endocrinology. 1996 Mar;137(3):1063-70 [8603575] Endocrinology. 1996 Nov;137(11):4796-805 [8895349] Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1476-81 [9037078] Nature. 1997 Dec 4;390(6659):509-12 [9393999] Endocrinology. 1998 Oct;139(10):4092-101 [9751487] Endocr Rev. 1999 Jun;20(3):358-417 [10368776] Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7986-91 [10393934] Brain Res. 1999 Jul 17;835(1):80-90 [10448199] Acta Endocrinol (Copenh). 1964 Apr;45:487-97 [14150595] Endocrinology. 2006 Aug;147(8):3666-78 [16627580] FASEB J. 2007 Feb;21(2):586-95 [17158782] Endocrinology. 2007 Nov;148(11):5288-94 [17673514] Development. 2000 Oct;127(19):4277-91 [10976058] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1677/JOE-10-0290 ER - TY - JOUR T1 - Models of membrane-bound Alzheimer's Abeta peptide assemblies. AN - 763257890; 20939098 AB - Although it is clear that amyloid beta (Aβ) peptides play a pivotal role in the development of Alzheimer's disease, the precise molecular model of action remains unclear. Aβ peptide forms assemble both in aqueous solution and in lipid membranes. It has been proposed that deleterious effects occur when the peptides interact with membranes, possibly by forming Ca(2+) permeant ion channels. In the accompanying manuscript, we propose models in which the C-terminus third of six Aβ42 peptides forms a six-stranded β-barrel in highly toxic soluble oligomers. Here we extend this hypothesis to membrane-bound assemblies. In these Aβ models, the hydrophobic β-barrel of a hexamer may either reside on the surface of the bilayer, or span the bilayer. Transmembrane pores are proposed to form between several hexamers. Once the β-barrels of six hexamers have spanned the bilayer, they may merge to form a more stable 36-stranded β-barrel. We favor models in which parallel β-barrels formed by N-terminus segments comprise the lining of the pores. These types of models explain why the channels are selective for cations and how metal ions, such as Zn(2+) , synthetic peptides that contain histidines, and some small organic cations may block channels or inhibit formation of channels. Our models were developed to be consistent with microscopy studies of Aβ assemblies in membranes, one of which is presented here for the first time. Copyright © 2010 Wiley-Liss, Inc. JF - Proteins AU - Shafrir, Yinon AU - Durell, Stewart AU - Arispe, Nelson AU - Guy, H Robert AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4258, USA. Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 3473 EP - 3487 VL - 78 IS - 16 KW - Amyloid beta-Peptides KW - 0 KW - MRS 2485 KW - Phenylpropionates KW - Pyridines KW - Index Medicus KW - Pyridines -- chemistry KW - Protein Structure, Secondary KW - Freeze Fracturing KW - Humans KW - Phenylpropionates -- metabolism KW - Phenylpropionates -- chemistry KW - Pyridines -- metabolism KW - Surface Properties KW - Protein Structure, Quaternary KW - Amyloid beta-Peptides -- metabolism KW - Models, Molecular KW - Amyloid beta-Peptides -- ultrastructure KW - Amyloid beta-Peptides -- chemistry KW - Cell Membrane -- ultrastructure KW - Cell Membrane -- metabolism KW - Alzheimer Disease -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/763257890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteins&rft.atitle=Models+of+membrane-bound+Alzheimer%27s+Abeta+peptide+assemblies.&rft.au=Shafrir%2C+Yinon%3BDurell%2C+Stewart%3BArispe%2C+Nelson%3BGuy%2C+H+Robert&rft.aulast=Shafrir&rft.aufirst=Yinon&rft.date=2010-12-01&rft.volume=78&rft.issue=16&rft.spage=3473&rft.isbn=&rft.btitle=&rft.title=Proteins&rft.issn=1097-0134&rft_id=info:doi/10.1002%2Fprot.22853 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-15 N1 - Date created - 2010-11-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 1998 Apr 3;280(5360):69-77 [9525859] Biochemistry. 1998 Aug 4;37(31):11064-77 [9693002] Science. 1998 Dec 18;282(5397):2220-6 [9856938] J Mol Biol. 1999 Jan 15;285(2):755-73 [9878442] Biochemistry. 1999 Mar 30;38(13):4137-42 [10194329] Nature. 1999 Jun 24;399(6738 Suppl):A23-31 [10392577] J Neurosci Res. 1999 Aug 15;57(4):458-66 [10440895] J Struct Biol. 2005 Jan;149(1):87-98 [15629660] Neurochem Res. 2004 Dec;29(12):2267-72 [15672549] Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3348-53 [19204293] Neurotox Res. 2009 Jul;16(1):1-13 [19526294] Nature. 2009 Jul 30;460(7255):592-8 [19641588] Nature. 2009 Jul 30;460(7255):599-604 [19641589] Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20021-6 [19901339] Biophys J. 2009 Dec 2;97(11):3029-37 [19948133] Biochemistry. 2010 Apr 13;49(14):3031-9 [20201586] Brain Res Bull. 2000 Nov 1;53(4):389-97 [11136994] J Biol Chem. 2001 Jun 8;276(23):20466-73 [11274207] Science. 2001 Aug 24;293(5534):1449-54 [11520976] Cell Mol Neurobiol. 2001 Jun;21(3):255-84 [11569537] FASEB J. 2001 Nov;15(13):2433-44 [11689468] Nature. 2002 Apr 4;416(6880):535-9 [11932745] Amyloid. 2002 Mar;9(1):13-23 [12000193] Peptides. 2002 Jul;23(7):1215-28 [12128079] Peptides. 2002 Jul;23(7):1311-5 [12128087] J Biol Chem. 2002 Aug 30;277(35):32046-53 [12058030] J Membr Biol. 2004 Nov;202(1):1-10 [15702375] Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10427-32 [16020533] J Am Chem Soc. 2005 Oct 5;127(39):13472-3 [16190691] Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17342-7 [16293696] Solid State Nucl Magn Reson. 2006 Feb;29(1-3):183-90 [16256316] Biochemistry. 2006 Jan 17;45(2):498-512 [16401079] Peptides. 2006 Jan;27(1):95-104 [16139931] J Mol Biol. 2006 Feb 24;356(3):759-70 [16403524] Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1546-50 [16432204] Nature. 2006 Mar 16;440(7082):352-7 [16541076] Biochemistry. 2006 May 2;45(17):5503-16 [16634632] J Neurosci. 2006 May 31;26(22):6011-8 [16738244] Biol Res. 2006;39(3):447-60 [17106577] J Gen Physiol. 2006 Dec;128(6):637-47 [17101816] J Mol Biol. 2007 May 11;368(4):982-97 [17382345] Nat Rev Neurosci. 2007 Jul;8(7):499-509 [17551515] Biochim Biophys Acta. 2007 Aug;1768(8):1935-42 [17382287] Biochim Biophys Acta. 2007 Aug;1768(8):1952-65 [17490607] J Biol Chem. 2008 Apr 18;283(16):10784-92 [18234670] Proteins. 2008 Jul;72(1):1-24 [18186465] Biophys J. 2008 Oct;95(8):3663-76 [18641074] Biophys J. 2008 Oct;95(8):3650-62 [18641075] Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18349-54 [19015532] Chembiochem. 2009 Jan 26;10(2):287-95 [19115328] J Mol Biol. 2009 Feb 13;386(1):81-96 [19111557] Phys Biol. 2009;6(1):015005 [19208933] Eur J Biochem. 2002 Nov;269(22):5642-8 [12423364] Science. 2002 Nov 22;298(5598):1582-7 [12446901] J Mol Biol. 2003 Jan 3;325(1):201-10 [12473462] Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):330-5 [12506200] J Mol Biol. 2004 Jan 23;335(4):1039-49 [14698298] Biophys J. 2004 Apr;86(4):2231-7 [15041662] J Biol Chem. 2004 Apr 23;279(17):17587-95 [14709559] J Comput Chem. 2004 Oct;25(13):1605-12 [15264254] Biophys J. 1970 Dec;10(12):1127-48 [5489777] Proc Natl Acad Sci U S A. 1986 Jan;83(2):508-12 [2417247] J Cell Biol. 1989 Jun;108(6):2255-75 [2738093] Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):567-71 [8380642] Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10573-7 [7504270] Ann Neurol. 1995 Mar;37(3):287-8 [7695227] Biophys J. 1994 Dec;67(6):2137-45 [7535109] J Mol Biol. 1996 Mar 1;256(3):623-44 [8604144] J Biol Chem. 1996 Oct 25;271(43):26482-9 [8900116] Science. 1996 Dec 13;274(5294):1859-66 [8943190] Biophys J. 1997 May;72(5):2002-13 [9129804] Biophys J. 1997 Jul;73(1):67-75 [9199772] J Mol Biol. 1998 Jan 30;275(4):541-5 [9466929] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/prot.22853 ER - TY - JOUR T1 - Naphthalimide based novel organoselenocyanates: finding less toxic forms of selenium that would retain protective efficacy. AN - 763174157; 20971640 AB - A series of naphthalimide based organoselenocyanates were synthesized and screened for their toxicity as well as their ability to modulate several detoxifying/antioxidative enzyme levels at a primary screening dose of 3 mg/kg b.w. in normal Swiss albino mice for 30 days. Compound 4d showed highest activity in elevating the detoxifying/antioxidant enzymes levels. Copyright © 2010 Elsevier Ltd. All rights reserved. JF - Bioorganic & medicinal chemistry letters AU - Roy, Somnath Singha AU - Ghosh, Prosenjit AU - Sk, Ugir Hossain AU - Chakraborty, Pramita AU - Biswas, Jaydip AU - Mandal, Syamsundar AU - Bhattacharjee, Arin AU - Bhattacharya, Sudin AD - Chittaranjan National Cancer Institute, Department of Cancer Chemoprevention, Kolkata, West Bengal, India. Y1 - 2010/12/01/ PY - 2010 DA - 2010 Dec 01 SP - 6951 EP - 6955 VL - 20 IS - 23 KW - Antioxidants KW - 0 KW - Cyanates KW - Naphthalimides KW - Organoselenium Compounds KW - Protective Agents KW - Oxidoreductases KW - EC 1.- KW - Index Medicus KW - Animals KW - Mice KW - Structure-Activity Relationship KW - Organoselenium Compounds -- pharmacology KW - Protective Agents -- chemical synthesis KW - Naphthalimides -- chemistry KW - Organoselenium Compounds -- toxicity KW - Organoselenium Compounds -- chemical synthesis KW - Protective Agents -- pharmacology KW - Drug Evaluation, Preclinical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/763174157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry+letters&rft.atitle=Naphthalimide+based+novel+organoselenocyanates%3A+finding+less+toxic+forms+of+selenium+that+would+retain+protective+efficacy.&rft.au=Roy%2C+Somnath+Singha%3BGhosh%2C+Prosenjit%3BSk%2C+Ugir+Hossain%3BChakraborty%2C+Pramita%3BBiswas%2C+Jaydip%3BMandal%2C+Syamsundar%3BBhattacharjee%2C+Arin%3BBhattacharya%2C+Sudin&rft.aulast=Roy&rft.aufirst=Somnath&rft.date=2010-12-01&rft.volume=20&rft.issue=23&rft.spage=6951&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry+letters&rft.issn=1464-3405&rft_id=info:doi/10.1016%2Fj.bmcl.2010.09.127 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-23 N1 - Date created - 2010-11-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bmcl.2010.09.127 ER - TY - JOUR T1 - The discovery of the microphthalmia locus and its gene, Mitf. AN - 760210491; 20807369 AB - The history of the discovery of the microphthalmia locus and its gene, now called Mitf, is a testament to the triumph of serendipity. Although the first microphthalmia mutation was discovered among the descendants of a mouse that was irradiated for the purpose of mutagenesis, the mutation most likely was not radiation induced but occurred spontaneously in one of the parents of a later breeding. Although Mitf might eventually have been identified by other molecular genetic techniques, it was first cloned from a chance transgene insertion at the microphthalmia locus. And although Mitf was found to encode a member of a well-known transcription factor family, its analysis might still be in its infancy had Mitf not turned out to be of crucial importance for the physiology and pathology of many distinct organs, including eye, ear, immune system, bone, and skin, and in particular for melanoma. In fact, near seven decades of Mitf research have led to many insights about development, function, degeneration, and malignancies of a number of specific cell types, and it is hoped that these insights will one day lead to therapies benefitting those afflicted with diseases originating in these cell types. JF - Pigment cell & melanoma research AU - Arnheiter, Heinz AD - Mammalian Development Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. ha3p@nih.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 729 EP - 735 VL - 23 IS - 6 KW - Microphthalmia-Associated Transcription Factor KW - 0 KW - Index Medicus KW - Animals KW - History, 20th Century KW - Humans KW - Cloning, Molecular KW - Microphthalmia-Associated Transcription Factor -- genetics KW - Microphthalmos -- genetics KW - Genetic Loci -- genetics KW - Microphthalmia-Associated Transcription Factor -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760210491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pigment+cell+%26+melanoma+research&rft.atitle=The+discovery+of+the+microphthalmia+locus+and+its+gene%2C+Mitf.&rft.au=Arnheiter%2C+Heinz&rft.aulast=Arnheiter&rft.aufirst=Heinz&rft.date=2010-12-01&rft.volume=23&rft.issue=6&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Pigment+cell+%26+melanoma+research&rft.issn=1755-148X&rft_id=info:doi/10.1111%2Fj.1755-148X.2010.00759.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-04 N1 - Date created - 2010-10-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Exp Med. 1998 Mar 2;187(5):775-85 [9480987] Am J Pathol. 1997 Oct;151(4):1043-51 [9327738] Mech Dev. 1998 Jan;70(1-2):155-66 [9510032] Dev Biol. 1998 Apr 15;196(2):145-59 [9576828] Mamm Genome. 1998 Aug;9(8):617-21 [9680380] Genomics. 1999 Feb 15;56(1):111-20 [10036191] Development. 1999 Sep;126(17):3757-67 [10433906] Annu Rev Genet. 2004;38:365-411 [15568981] Nat Genet. 2007 Nov;39(11):1321-8 [17906626] J Cell Sci. 2008 Jan 15;121(Pt 2):167-77 [18089649] Development. 2008 Mar;135(6):1169-78 [18272592] Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8989-93 [18577593] J Genet. 1948 May;49(1):1-13 [18873488] Dev Biol. 2009 Aug 15;332(2):383-95 [19520072] Genetics. 2009 Oct;183(2):581-94 [19635938] Pigment Cell Melanoma Res. 2010 Feb;23(1):27-40 [19995375] Pigment Cell Melanoma Res. 2010 Jun;23(3):441-7 [20374522] Development. 2000 Aug;127(16):3581-91 [10903182] Development. 2000 Dec;127(24):5379-89 [11076759] Genetics. 2003 Jan;163(1):267-76 [12586714] Development. 2003 Oct;130(19):4655-64 [12925591] Genetics. 2004 May;167(1):233-41 [15166150] Hear Res. 1987;27(1):11-26 [3583934] Blood. 1990 Mar 15;75(6):1247-51 [2310824] Cell. 1993 Jul 30;74(2):395-404 [8343963] J Biol Chem. 1993 Oct 5;268(28):20687-90 [8407885] Hum Mol Genet. 1994 Apr;3(4):553-7 [8069297] Genes Dev. 1994 Nov 15;8(22):2770-80 [7958932] Nat Genet. 1994 Nov;8(3):251-5 [7874167] Nat Genet. 1994 Nov;8(3):256-63 [7874168] Biochem J. 1995 Oct 1;311 ( Pt 1):293-7 [7575467] Development. 1997 Jun;124(12):2377-86 [9199364] Hum Mol Genet. 1998 Apr;7(4):703-8 [9499424] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1755-148X.2010.00759.x ER - TY - JOUR T1 - Chemistry of the cysteine sensors in Kelch-like ECH-associated protein 1. AN - 759134428; 20486763 AB - The protein Kelch-like ECH-associated protein 1 (Keap1) is a cysteine-rich regulatory and scaffold protein. Human Keap1 contains 27 cysteines. Some of these cysteines are believed to mediate derepression of the transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which subsequently upregulates phase 2 enzymes, in response to electrophilic/oxidative assault. Some current models depict a highly select group of two and possibly a few more cysteine residues as key sensors. The assumptions and approaches undergirding these models are commented upon. The chemical reactivity of the cysteines of Keap1 toward an array of electrophiles and one oxidant is reviewed. A number of reports in the recent literature of molecules that putatively modify cysteines of Keap1 are also included. Insights into the current molecular basis of electrophile/oxidant activation of the Nrf2 pathway via reaction at cysteines of Keap1 are discussed. Finally, important knowns and unknowns are summarized. JF - Antioxidants & redox signaling AU - Holland, Ryan AU - Fishbein, James C AD - The Laboratory of Comparative Carcinogenesis, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA. Y1 - 2010/12/01/ PY - 2010 DA - 2010 Dec 01 SP - 1749 EP - 1761 VL - 13 IS - 11 KW - Intracellular Signaling Peptides and Proteins KW - 0 KW - KEAP1 protein, human KW - Kelch-Like ECH-Associated Protein 1 KW - NF-E2-Related Factor 2 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Oxidation-Reduction KW - Animals KW - Humans KW - NF-E2-Related Factor 2 -- genetics KW - NF-E2-Related Factor 2 -- chemistry KW - Up-Regulation KW - Response Elements KW - Protein Binding KW - NF-E2-Related Factor 2 -- metabolism KW - Intracellular Signaling Peptides and Proteins -- genetics KW - Cysteine -- metabolism KW - Cysteine -- chemistry KW - Intracellular Signaling Peptides and Proteins -- metabolism KW - Intracellular Signaling Peptides and Proteins -- chemistry KW - Cysteine -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759134428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antioxidants+%26+redox+signaling&rft.atitle=Chemistry+of+the+cysteine+sensors+in+Kelch-like+ECH-associated+protein+1.&rft.au=Holland%2C+Ryan%3BFishbein%2C+James+C&rft.aulast=Holland&rft.aufirst=Ryan&rft.date=2010-12-01&rft.volume=13&rft.issue=11&rft.spage=1749&rft.isbn=&rft.btitle=&rft.title=Antioxidants+%26+redox+signaling&rft.issn=1557-7716&rft_id=info:doi/10.1089%2Fars.2010.3273 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-04-18 N1 - Date created - 2010-10-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Free Radic Biol Med. 1999 Dec;27(11-12):1208-18 [10641713] J Cell Sci. 2009 Dec 15;122(Pt 24):4452-64 [19920073] Free Radic Biol Med. 2001 Jun 1;30(11):1191-212 [11368918] Oncogene. 2001 Jun 28;20(29):3906-17 [11439354] Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11908-13 [12193649] J Biol Chem. 2002 Sep 27;277(39):36544-52 [12145307] Genes Cells. 2003 Apr;8(4):379-91 [12653965] Adv Enzyme Regul. 2003;43:121-34 [12791387] Mol Cell Biol. 2003 Nov;23(22):8137-51 [14585973] Biochem J. 2004 Mar 1;378(Pt 2):373-82 [14616092] Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2040-5 [14764894] Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2046-51 [14764898] J Biol Chem. 2004 Jun 11;279(24):25813-22 [15073169] Mol Cell Biol. 2004 Aug;24(16):7130-9 [15282312] Environ Health Perspect. 1997 Jun;105 Suppl 4:965-70 [9255588] Genes Dev. 1999 Jan 1;13(1):76-86 [9887101] FASEB J. 1999 Sep;13(12):1481-90 [10463938] Mol Cell Biol. 2004 Dec;24(24):10941-53 [15572695] Mol Cell Biol. 2005 Jan;25(1):162-71 [15601839] Biochem J. 2005 Mar 1;386(Pt 2):215-9 [15647005] Biochemistry. 2005 May 10;44(18):6889-99 [15865434] Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10070-5 [16006525] J Biol Chem. 2005 Sep 9;280(36):31768-75 [15985429] Chem Res Toxicol. 2005 Dec;18(12):1779-91 [16359168] Chem Res Toxicol. 2005 Dec;18(12):1917-26 [16359182] Cancer Res. 2006 Feb 1;66(3):1740-50 [16452234] J Agric Food Chem. 2006 Mar 8;54(5):1656-62 [16506816] J Biol Chem. 2006 Aug 25;281(34):24756-68 [16790436] Chem Res Toxicol. 2006 Sep;19(9):1196-204 [16978024] Chem Res Toxicol. 2006 Nov;19(11):1499-505 [17112238] J Biol Chem. 2007 Jan 26;282(4):2529-37 [17127771] Mol Cell Biol. 2007 Sep;27(18):6334-49 [17636022] Biochem Biophys Res Commun. 2007 Nov 3;362(4):816-21 [17822677] Genes Cells. 2007 Oct;12(10):1163-78 [17903176] J Neurochem. 2008 Feb;104(4):1116-31 [17995931] Free Radic Biol Med. 2008 Feb 15;44(4):692-8 [18062931] Carcinogenesis. 2008 Mar;29(3):594-9 [17916901] Chem Res Toxicol. 2008 Mar;21(3):705-10 [18251510] Biochem J. 2008 Apr 15;411(2):297-306 [18237271] Mol Cell Biol. 2008 Apr;28(8):2758-70 [18268004] Pharm Res. 2008 Apr;25(4):836-44 [17657593] Chem Res Toxicol. 2008 Apr;21(4):805-12 [18361512] Eur J Nutr. 2008 May;47 Suppl 2:73-88 [18458837] Free Radic Biol Med. 2008 Aug 15;45(4):385-95 [18482591] Toxicol Appl Pharmacol. 2008 Aug 1;230(3):383-9 [18417180] Chem Res Toxicol. 2008 Jul;21(7):1375-83 [18512965] Int J Oncol. 2008 Oct;33(4):833-8 [18813798] Chem Res Toxicol. 2008 Oct;21(10):2051-60 [18729328] Chem Res Toxicol. 2008 Oct;21(10):1939-48 [18808158] Mol Cell Biol. 2009 Jan;29(2):493-502 [19001094] Biochem Biophys Res Commun. 2009 Feb 6;379(2):537-41 [19118528] Trends Biochem Sci. 2009 Apr;34(4):176-88 [19321346] J Biol Chem. 2009 May 8;284(19):12886-95 [19279006] J Biol Chem. 2009 May 15;284(20):13291-5 [19182219] Biochem J. 2009 Aug 15;422(1):171-80 [19489739] Free Radic Biol Med. 2009 Sep 1;47(5):659-67 [19524036] Biosci Biotechnol Biochem. 2009 Aug;73(8):1905-7 [19661711] Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14547-51 [19706542] Clin Cancer Res. 2009 Sep 1;15(17):5414-25 [19690198] Chem Res Toxicol. 2009 Aug;22(8):1427-34 [19785463] J Biol Chem. 2009 Oct 2;284(40):27721-33 [19643729] Carcinogenesis. 2009 Oct;30(10):1754-62 [19633057] Antioxid Redox Signal. 2009 May;11(5):949-62 [19123792] Eur J Biochem. 2000 Aug;267(16):4928-44 [10931175] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/ars.2010.3273 ER - TY - JOUR T1 - Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC. AN - 755969946; 20533281 AB - The "Warburg effect," also termed aerobic glycolysis, describes the increased reliance of cancer cells on glycolysis for ATP production, even in the presence of oxygen. Consequently, there is continued interest in inhibitors of glycolysis as cancer therapeutics. One example is dichloroacetate (DCA), a pyruvate mimetic that stimulates oxidative phosphorylation through inhibition of pyruvate dehydrogenase kinase. In this study, the mechanistic basis for DCA anti-cancer activity was re-evaluated in vitro using biochemical, cellular and proteomic approaches. Results demonstrated that DCA is relatively inactive (IC(50) ≥ 17 mM, 48 hr), induces apoptosis only at high concentrations (≥ 25 mM, 48 hr) and is not cancer cell selective. Subsequent 2D-PAGE proteomic analysis confirmed DCA-induced growth suppression without apoptosis induction. Furthermore, DCA depolarizes mitochondria and promotes reactive oxygen species (ROS) generation in all cell types. However, DCA was found to have selective activity against rho(0) cells [mitochondrial DNA (mtDNA) deficient] and to synergize with 2-deoxyglucose in complex IV deficient HCT116 p53(-/-) cells. DCA also synergized in vitro with cisplatin and topotecan, two antineoplastic agents known to damage mitochondrial DNA. These data suggest that in cells "hardwired" to selectively utilize glycolysis for ATP generation (e.g., through mtDNA mutations), the ability of DCA to force oxidative phosphorylation confers selective toxicity. In conclusion, although we provide a mechanism distinct from that reported previously, the ability of DCA to target cell lines with defects in the electron transport chain and to synergize with existing chemotherapeutics supports further preclinical development. JF - International journal of cancer AU - Stockwin, Luke H AU - Yu, Sherry X AU - Borgel, Suzanne AU - Hancock, Chad AU - Wolfe, Tracy L AU - Phillips, Lawrence R AU - Hollingshead, Melinda G AU - Newton, Dianne L AD - Biological Testing Branch, Developmental Therapeutics Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD 21702, USA. Y1 - 2010/12/01/ PY - 2010 DA - 2010 Dec 01 SP - 2510 EP - 2519 VL - 127 IS - 11 KW - Dichloroacetic Acid KW - 9LSH52S3LQ KW - Index Medicus KW - Animals KW - Electron Transport KW - Dose-Response Relationship, Drug KW - HL-60 Cells KW - Humans KW - Lung Neoplasms -- drug therapy KW - Rabbits KW - Cell Line, Tumor KW - HCT116 Cells KW - Membrane Potential, Mitochondrial -- drug effects KW - Cell Survival -- drug effects KW - Proteomics KW - Apoptosis -- drug effects KW - Xenograft Model Antitumor Assays KW - Glycolysis KW - Mitochondria -- drug effects KW - Mitochondria -- metabolism KW - Dichloroacetic Acid -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755969946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Sodium+dichloroacetate+selectively+targets+cells+with+defects+in+the+mitochondrial+ETC.&rft.au=Stockwin%2C+Luke+H%3BYu%2C+Sherry+X%3BBorgel%2C+Suzanne%3BHancock%2C+Chad%3BWolfe%2C+Tracy+L%3BPhillips%2C+Lawrence+R%3BHollingshead%2C+Melinda+G%3BNewton%2C+Dianne+L&rft.aulast=Stockwin&rft.aufirst=Luke&rft.date=2010-12-01&rft.volume=127&rft.issue=11&rft.spage=2510&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.25499 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-04 N1 - Date created - 2010-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.25499 ER - TY - JOUR T1 - A pilot study of interpersonal psychotherapy for preventing excess weight gain in adolescent girls at-risk for obesity AN - 1837338192; 15034118 AB - Objective Interpersonal psychotherapy (IPT) is effective at reducing binge episodes and inducing weight stabilization in obese adults with binge eating disorder. Method We piloted the administration of IPT to girls at-risk for excess weight gain (BMI 75th-97th percentile; IPT-WG) with and without loss of control (LOC) eating. Thirty-eight girls (12-17 years) were randomized to IPT-WG or a standard-of-care health education group. Results All 38 girls completed the programs and all follow-up visits through 6 months. Thirty-five of 38 returned for a complete assessment visit at 1 year. Among girls with baseline LOC (n = 20), those in IPT-WG experienced greater reductions in such episodes than girls in health education (p = .036). Regardless of LOC status, over 1 year girls in IPT-WG were less likely to increase their BMI as expected for their age and BMI percentile (p = .028). Discussion IPT-WG is feasible and acceptable to adolescent girls at-risk for adult obesity and may prevent excess weight gain over 1 year. [copy 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2010; 43:701-706 JF - International Journal of Eating Disorders AU - Tanofsky-Kraff, Marian AU - Wilfley, Denise E AU - Young, Jami F AU - Mufson, Laura AU - Yanovski, Susan Z AU - Glasofer, Deborah R AU - Salaita, Christine G AU - Schvey, Natasha A AD - Unit on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Heath and Human Development, National Institutes of Health, DHHS, Bethesda, Maryland, mtanofsky@usuhs.mil Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 701 EP - 706 VL - 43 IS - 8 SN - 1098-108X, 1098-108X KW - Physical Education Index KW - Obesity KW - Eating disorders KW - Girls KW - Body mass KW - Adolescence KW - Objectives KW - Diet (weight control) KW - Adults KW - Health (education) KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837338192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Eating+Disorders&rft.atitle=A+pilot+study+of+interpersonal+psychotherapy+for+preventing+excess+weight+gain+in+adolescent+girls+at-risk+for+obesity&rft.au=Tanofsky-Kraff%2C+Marian%3BWilfley%2C+Denise+E%3BYoung%2C+Jami+F%3BMufson%2C+Laura%3BYanovski%2C+Susan+Z%3BGlasofer%2C+Deborah+R%3BSalaita%2C+Christine+G%3BSchvey%2C+Natasha+A&rft.aulast=Tanofsky-Kraff&rft.aufirst=Marian&rft.date=2010-12-01&rft.volume=43&rft.issue=8&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Eating+Disorders&rft.issn=1098108X&rft_id=info:doi/10.1002%2Feat.20773 L2 - http://onlinelibrary.wiley.com/doi/10.1002/eat.20773/abstract LA - English DB - Physical Education Index N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Obesity; Eating disorders; Objectives; Adolescence; Body mass; Girls; Diet (weight control); Adults; Health (education) DO - http://dx.doi.org/10.1002/eat.20773 ER - TY - JOUR T1 - Compatibility of superparamagnetic iron oxide nanoparticle labeling for 1H MRI cell tracking with 31P MRS for bioenergetic measurements AN - 1017970965; 16700577 AB - Labeling of cells with superparamagnetic iron oxide nanoparticles permits cell tracking by 1H MRI while 31P MRS allows non-invasive evaluation of cellular bioenergetics. We evaluated the compatibility of these two techniques by obtaining 31P NMR spectra of iron-labeled and unlabeled immobilized C2C12 myoblast cells in vitro. Broadened but usable 31P spectra were obtained and peak area ratios of resonances corresponding to intracellular metabolites showed no significant differences between labeled and unlabeled cell populations. We conclude that 31P NMR spectra can be obtained from cells labeled with sufficient iron to permit visualization by 1H imaging protocols and that these spectra have sufficient quality to be used to assess metabolic status. This result introduces the possibility of using localized 31P MRS to evaluate the viability of iron-labeled therapeutic cells as well as surrounding host tissue in vivo. Published in 2010 by John Wiley & Sons, Ltd. JF - NMR in Biomedicine AU - Zhang, Zhuoli AU - Hancock, Brynne AU - Leen, Stephanie AU - Ramaswamy, Sharan AU - Sollott, Steven J AU - Boheler, Kenneth R AU - Juhaszova, Magdalena AU - Lakatta, Edward G AU - Spencer, Richard G AU - Fishbein, Kenneth W AD - Laboratory of Cardiovascular Science, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA, kf31x@nih.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1166 EP - 1172 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 23 IS - 10 SN - 1099-1492, 1099-1492 KW - Biotechnology and Bioengineering Abstracts KW - Bioenergetics KW - Iron KW - Magnetic resonance imaging KW - Metabolites KW - Myoblasts KW - N.M.R. KW - iron oxides KW - nanoparticles KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017970965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=Compatibility+of+superparamagnetic+iron+oxide+nanoparticle+labeling+for+1H+MRI+cell+tracking+with+31P+MRS+for+bioenergetic+measurements&rft.au=Zhang%2C+Zhuoli%3BHancock%2C+Brynne%3BLeen%2C+Stephanie%3BRamaswamy%2C+Sharan%3BSollott%2C+Steven+J%3BBoheler%2C+Kenneth+R%3BJuhaszova%2C+Magdalena%3BLakatta%2C+Edward+G%3BSpencer%2C+Richard+G%3BFishbein%2C+Kenneth+W&rft.aulast=Zhang&rft.aufirst=Zhuoli&rft.date=2010-12-01&rft.volume=23&rft.issue=10&rft.spage=1166&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=10991492&rft_id=info:doi/10.1002%2Fnbm.1545 L2 - http://onlinelibrary.wiley.com/doi/10.1002/nbm.1545/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - iron oxides; Bioenergetics; Magnetic resonance imaging; Myoblasts; Metabolites; N.M.R.; Iron; nanoparticles DO - http://dx.doi.org/10.1002/nbm.1545 ER - TY - JOUR T1 - Does laser type impact myocardial function following transmyocardial laser revascularization? AN - 1017967382; 16686153 AB - Background Transmyocardial laser revascularization (TMR) is currently clinically performed with either a CO2 or Ho:YAG laser for the treatment of severe angina. While both lasers provide symptomatic relief, there are significant differences in the laser-tissue interactions specific to each device that may impact their ability to enhance the perfusion of myocardium and thereby improve contractile function of the ischemic heart. Methods A porcine model of chronic myocardial ischemia was employed. After collecting baseline functional data with cine magnetic resonance imaging (MRI) and dobutamine stress echo (DSE), 14 animals underwent TMR with either a CO2 or Ho:YAG laser. Transmural channels were created with each laser in a distribution of 1/cm2 in the ischemic zone. Six weeks post-treatment repeat MRI as well as DSE were obtained after which the animals were sacrificed. Histology was preformed to characterize the laser-tissue interaction. Results CO2 TMR led to improvement in wall thickening in the ischemic area as seen with cine MRI (40.3% vs. baseline, P<0.05) and DSE (20.2% increase vs. baseline, P<0.05). Ho:YAG treated animals had no improvement in wall thickening by MRI (-11.6% vs. baseline, P=.67) and DSE (-16.7% vs. baseline, P=0.08). Correlative semi-quantitative histology revealed a significantly higher fibrosis index in Ho:YAG treated myocardium versus CO2 (1.81 vs. 0.083, P<0.05). Conclusions In a side-by-side comparison CO2 TMR resulted in improved function of ischemic myocardium as assessed by MRI and echocardiography. Ho:YAG TMR led to no improvement in regional function likely due to concomitant increase in fibrosis in the lasered area. Lasers Surg. Med. 42:746-751, 2010. ? 2010 Wiley-Liss, Inc. JF - Lasers in Surgery and Medicine AU - Estvold, Soren K AU - Mordini, Frederico AU - Zhou, Yifu AU - Yu, Zu X AU - Sachdev, Vandana AU - Arai, Andrew AU - Horvath, Keith A Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 746 EP - 751 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 42 IS - 10 SN - 1096-9101, 1096-9101 KW - Biotechnology and Bioengineering Abstracts KW - Angina KW - Carbon dioxide KW - Data processing KW - Echocardiography KW - Fibrosis KW - Heart KW - Ischemia KW - Lasers KW - Magnetic resonance imaging KW - Muscle contraction KW - Myocardial ischemia KW - Myocardium KW - Perfusion KW - Stress KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017967382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lasers+in+Surgery+and+Medicine&rft.atitle=Does+laser+type+impact+myocardial+function+following+transmyocardial+laser+revascularization%3F&rft.au=Estvold%2C+Soren+K%3BMordini%2C+Frederico%3BZhou%2C+Yifu%3BYu%2C+Zu+X%3BSachdev%2C+Vandana%3BArai%2C+Andrew%3BHorvath%2C+Keith+A&rft.aulast=Estvold&rft.aufirst=Soren&rft.date=2010-12-01&rft.volume=42&rft.issue=10&rft.spage=746&rft.isbn=&rft.btitle=&rft.title=Lasers+in+Surgery+and+Medicine&rft.issn=10969101&rft_id=info:doi/10.1002%2Flsm.21012 L2 - http://onlinelibrary.wiley.com/doi/10.1002/lsm.21012/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Heart; Muscle contraction; Myocardial ischemia; Perfusion; Data processing; Fibrosis; Angina; Magnetic resonance imaging; Echocardiography; Stress; Ischemia; Lasers; Carbon dioxide; Myocardium DO - http://dx.doi.org/10.1002/lsm.21012 ER - TY - JOUR T1 - Recent trends and future directions in human immunodeficiency virus-associated cancer AN - 1017962786; 16688960 AB - Malignancies, including the 3 that are part of the definition of the acquired immunodeficiency syndrome (AIDS) (Kaposi sarcoma [KS], non-Hodgkin lymphoma [NHL], and cervical cancer) as well as certain non-AIDS-defining cancers, cause significant morbidity and an estimated 33% of the deaths reported among patients infected with the human immunodeficiency virus (HIV). The US Multicenter AIDS Cohort Study (MACS) analysis highlighted several interesting and important trends in AIDS-defining and non-AIDS-defining cancers among individuals infected with HIV. JF - Cancer AU - Shiels, Meredith S AU - Goedert, James J AU - Engels, Eric A Y1 - 2010/12/01/ PY - 2010 DA - 2010 Dec 01 SP - 5344 EP - 5347 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 116 IS - 23 SN - 1097-0142, 1097-0142 KW - Immunology Abstracts; Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - non-Hodgkin's lymphoma KW - Mortality KW - Acquired immune deficiency syndrome KW - Cervical cancer KW - Immunodeficiency KW - Cancer KW - Morbidity KW - Malignancy KW - Human immunodeficiency virus KW - Sarcoma KW - Lymphoma KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017962786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Recent+trends+and+future+directions+in+human+immunodeficiency+virus-associated+cancer&rft.au=Shiels%2C+Meredith+S%3BGoedert%2C+James+J%3BEngels%2C+Eric+A&rft.aulast=Shiels&rft.aufirst=Meredith&rft.date=2010-12-01&rft.volume=116&rft.issue=23&rft.spage=5344&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=10970142&rft_id=info:doi/10.1002%2Fcncr.25705 L2 - http://onlinelibrary.wiley.com/doi/10.1002/cncr.25705/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Malignancy; Acquired immune deficiency syndrome; Cervical cancer; Sarcoma; Immunodeficiency; Lymphoma; Morbidity; non-Hodgkin's lymphoma; Mortality; Human immunodeficiency virus; Cancer DO - http://dx.doi.org/10.1002/cncr.25705 ER - TY - JOUR T1 - The Function and Three-Dimensional Structure of a Thromboxane A2/Cysteinyl Leukotriene-Binding Protein from the Saliva of a Mosquito Vector of the Malaria Parasite AN - 862793271; 14161215 AB - A salivary protein from a malaria-transmitting mosquito uses a single domain to bind to thromboxane A2 and cysteinyl leukotrienes and prevent blood clotting and inflammation in the host on which it feeds. The highly expressed D7 protein family of mosquito saliva has previously been shown to act as an anti-inflammatory mediator by binding host biogenic amines and cysteinyl leukotrienes (CysLTs). In this study we demonstrate that AnSt-D7L1, a two-domain member of this group from Anopheles stephensi, retains the CysLT binding function seen in the homolog AeD7 from Aedes aegypti but has lost the ability to bind biogenic amines. Unlike any previously characterized members of the D7 family, AnSt-D7L1 has acquired the important function of binding thromboxane A2 (TXA2) and its analogs with high affinity. When administered to tissue preparations, AnSt-D7L1 abrogated Leukotriene C4 (LTC4)-induced contraction of guinea pig ileum and contraction of rat aorta by the TXA2 analog U46619. The protein also inhibited platelet aggregation induced by both collagen and U46619 when administered to stirred platelets. The crystal structure of AnSt-D7L1 contains two OBP-like domains and has a structure similar to AeD7. In AnSt-D7L1, the binding pocket of the C-terminal domain has been rearranged relative to AeD7, making the protein unable to bind biogenic amines. Structures of the ligand complexes show that CysLTs and TXA2 analogs both bind in the same hydrophobic pocket of the N-terminal domain. The TXA2 analog U46619 is stabilized by hydrogen bonding interactions of the omega -5 hydroxyl group with the phenolic hydroxyl group of Tyr 52. LTC4 and occupies a very similar position to LTE4 in the previously determined structure of its complex with AeD7. As yet, it is not known what, if any, new function has been acquired by the rearranged C-terminal domain. This article presents, to our knowledge, the first structural characterization of a protein from mosquito saliva that inhibits collagen mediated platelet activation. When feeding, a female mosquito must inhibit the blood clotting and inflammatory responses of the host. To do this, the insect produces salivary proteins that neutralize key host molecules participating in clotting and inflammation. Here, we describe a salivary protein AnSt-D7L1 that scavenges both thomboxane A2 and cysteinyl leukotrienes, two substances involved in blood vessel constriction, platelet aggregation, and inflammatory responses to an insect bite. We produced this protein in bacteria and showed that it tightly binds both these molecules, inhibiting the processes in which they are involved. We then determined its structure using X-ray crystallography and showed that there is a single binding site in one domain of the protein, accommodating both thromboxane A2 and cysteinyl leukotrienes, and that this site is responsible for the scavenging effect of the protein. These studies reveal the structural features of proteins needed to bind to key molecules of potential pharmacological importance and add to our understanding of the process of mosquito blood feeding, which is essential for transmission of the malaria parasite. JF - PLoS Biology AU - Alvarenga, Patricia H AU - Francischetti, Ivo MB AU - Calvo, Eric AU - Sa-Nunes, Anderson AU - Ribeiro, Jose MC AU - Andersen, John F AD - Laboratory of Malaria and Vector Research, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rockville, Maryland, United States of America Y1 - 2010/11/30/ PY - 2010 DA - 2010 Nov 30 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 USA VL - 8 IS - 1 SN - 1544-9173, 1544-9173 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; Entomology Abstracts KW - Parasites KW - Aedes aegypti KW - Human diseases KW - Platelet aggregation KW - Bites KW - Analogs KW - Anopheles stephensi KW - Hydrophobicity KW - Malaria KW - Hosts KW - Public health KW - Collagen KW - Clotting KW - Blood vessels KW - Structure-function relationships KW - Crystal structure KW - phenolic compounds KW - Aquatic insects KW - Biogenic amines KW - Leukotrienes KW - Feeding KW - Livestock food KW - Aorta KW - protein families KW - Vectors KW - Ileum KW - Amines KW - Thromboxane A2 KW - Inflammation KW - X-ray crystallography KW - Blood coagulation KW - Hydrogen bonding KW - Saliva KW - K 03410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862793271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Biology&rft.atitle=The+Function+and+Three-Dimensional+Structure+of+a+Thromboxane+A2%2FCysteinyl+Leukotriene-Binding+Protein+from+the+Saliva+of+a+Mosquito+Vector+of+the+Malaria+Parasite&rft.au=Alvarenga%2C+Patricia+H%3BFrancischetti%2C+Ivo+MB%3BCalvo%2C+Eric%3BSa-Nunes%2C+Anderson%3BRibeiro%2C+Jose+MC%3BAndersen%2C+John+F&rft.aulast=Alvarenga&rft.aufirst=Patricia&rft.date=2010-11-30&rft.volume=8&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Biology&rft.issn=15449173&rft_id=info:doi/10.1371%2Fjournal.pbio.1000547 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Livestock food; Human diseases; Analogs; Malaria; Hosts; Amines; Aquatic insects; Collagen; Public health; Leukotrienes; Biogenic amines; Parasites; Feeding; Bites; Platelet aggregation; Aorta; Vectors; protein families; Hydrophobicity; Ileum; Thromboxane A2; Inflammation; X-ray crystallography; Blood coagulation; Clotting; Blood vessels; Hydrogen bonding; Structure-function relationships; Crystal structure; phenolic compounds; Saliva; Aedes aegypti; Anopheles stephensi DO - http://dx.doi.org/10.1371/journal.pbio.1000547 ER - TY - JOUR T1 - DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine. AN - 812137391; 20696268 AB - An aerobic environment burdens DNA polymerase substrates with oxidized substrates (DNA and nucleotide pools). A major promutagenic lesion resulting from oxidative stress is 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxoG). Guanine oxidation alters the hydrogen bonding properties of the base and glycosidic-preference of the nucleotide. The favored glycosidic syn-conformation exposes the Hoogsteen edge of the base for hydrogen bonding with adenine during DNA synthesis. The cell has recognized the threat of this lesion and has evolved an intricate surveillance system to provide DNA polymerases with unmodified substrates. Failure to do so leads to transversion mutations. Since the mutagenic properties of the base are dictated by the anti-syn-conformation of the nucleotide, the molecular interactions of 8-oxoG in the confines of the DNA polymerase active site are expected to influence its coding potential. Recent structural characterization of DNA polymerases from several families with this lesion in the nascent base pair binding pocket has provided insight to the mutagenic properties of this modified nucleotide. These structures reveal that flexibility around the template-binding pocket can permit 8-oxoG to assume an anti- or syn-conformation and code for cytosine or adenine incorporation, respectively. In contrast, the binding pocket for the incoming nucleotide does not have this flexibility so that 8-oxodGTP insertion opposite cytosine is strongly discouraged. Published by Elsevier B.V. JF - Mutation research AU - Beard, William A AU - Batra, Vinod K AU - Wilson, Samuel H AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2010/11/28/ PY - 2010 DA - 2010 Nov 28 SP - 18 EP - 23 VL - 703 IS - 1 SN - 0027-5107, 0027-5107 KW - Mutagens KW - 0 KW - 8-hydroxyguanine KW - 5614-64-2 KW - Guanine KW - 5Z93L87A1R KW - DNA Polymerase beta KW - EC 2.7.7.- KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Phosphoric Monoester Hydrolases KW - EC 3.1.3.2 KW - 8-oxodGTPase KW - EC 3.6.1.55 KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Index Medicus KW - Phosphoric Monoester Hydrolases -- chemistry KW - Animals KW - DNA Repair KW - Models, Molecular KW - DNA Damage KW - Humans KW - Oxidative Stress KW - DNA Polymerase beta -- chemistry KW - DNA Repair Enzymes -- chemistry KW - Structure-Activity Relationship KW - Guanine -- chemistry KW - Guanine -- analogs & derivatives KW - DNA-Directed DNA Polymerase -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/812137391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=DNA+polymerase+structure-based+insight+on+the+mutagenic+properties+of+8-oxoguanine.&rft.au=Beard%2C+William+A%3BBatra%2C+Vinod+K%3BWilson%2C+Samuel+H&rft.aulast=Beard&rft.aufirst=William&rft.date=2010-11-28&rft.volume=703&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/10.1016%2Fj.mrgentox.2010.07.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-21 N1 - Date created - 2010-11-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochemistry. 2000 Feb 8;39(5):1029-33 [10653647] Prog Nucleic Acid Res Mol Biol. 2001;68:75-94 [11554314] Prog Nucleic Acid Res Mol Biol. 2001;68:95-105 [11554315] Prog Nucleic Acid Res Mol Biol. 2001;68:107-23 [11554290] J Biol Chem. 2002 Mar 8;277(10):8235-42 [11756435] Oncogene. 2002 Dec 16;21(58):8895-904 [12483507] Structure. 2003 Jan;11(1):121-7 [12517346] DNA Repair (Amst). 2003 Feb 3;2(2):159-73 [12531387] EMBO J. 2004 Apr 7;23(7):1494-505 [15057282] J Comput Chem. 2004 Oct;25(13):1605-12 [15264254] EMBO J. 2004 Sep 1;23(17):3452-61 [15297882] Nature. 2004 Sep 9;431(7005):217-21 [15322558] J Am Chem Soc. 1977 May 11;99(10):3250-3 [853179] Mutat Res. 1987 Oct;192(2):83-9 [3657846] Biochemistry. 1991 Feb 5;30(5):1403-12 [1991121] Nucleic Acids Res. 1991 Apr 11;19(7):1407-12 [2027747] Mutat Res. 1991 Sep-Oct;250(1-2):3-16 [1944345] Chem Res Toxicol. 1989 Nov-Dec;2(6):416-22 [2519731] J Bacteriol. 1992 Oct;174(20):6321-5 [1328155] Trends Genet. 1993 Jul;9(7):246-9 [8379000] Biochemistry. 1994 Aug 30;33(34):10266-70 [8068665] Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):719-23 [7846041] Structure. 2005 Nov;13(11):1653-9 [16271888] J Biol Chem. 2006 Jan 27;281(4):2358-72 [16306039] Chem Rev. 2006 Feb;106(2):361-82 [16464010] PLoS Biol. 2006 Jan;4(1):e11 [16379496] Structure. 2006 Apr;14(4):757-66 [16615916] J Mol Biol. 2007 Apr 13;367(5):1258-69 [17321545] Nature. 2007 May 31;447(7144):606-8 [17507928] J Biol Chem. 2007 Jul 6;282(27):19831-43 [17468100] Mol Cell. 2008 May 9;30(3):315-24 [18471977] Clin Genet. 2008 Jun;73(6):545-53 [18422726] Structure. 2009 May 13;17(5):725-36 [19446528] J Biol Chem. 2009 Aug 14;284(33):22467-80 [19542228] J Biol Chem. 2009 Nov 13;284(46):31680-9 [19759017] Biochemistry. 2010 May 18;49(19):4116-25 [20411947] Nat Struct Mol Biol. 2010 Jul;17(7):889-90 [20526335] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mrgentox.2010.07.013 ER - TY - JOUR T1 - Chronic Ethanol Consumption-induced Pancreatic beta -Cell Dysfunction and Apoptosis through Glucokinase Nitration and Its Down-regulation AN - 860379078; 14106755 AB - Chronic ethanol consumption is known as an independent risk factor for type 2 diabetes, which is characterized by impaired glucose homeostasis and insulin resistance; however, there is a great deal of controversy concerning the relationships between alcohol consumption and the development of type 2 diabetes. We investigated the effects of chronic ethanol consumption on pancreatic beta -cell dysfunction and whether generated peroxynitrite participates in the impaired glucose homeostasis. Here we show that chronic ethanol feeding decreases the ability of pancreatic beta -cells to mediate insulin secretion and ATP production in coordination with the decrease of glucokinase, Glut2, and insulin expression. Specific blockade of ATF3 using siRNA or C-terminally deleted ATF3( Delta C) attenuated ethanol-induced pancreatic beta -cell apoptosis or dysfunction and restored the down-regulation of glucokinase (GCK), insulin, and pancreatic duodenal homeobox-1 induced by ethanol. GCK inactivation and down-regulation were predominantly mediated by ethanol metabolism-generated peroxynitrite, which were suppressed by the peroxynitrite scavengers N gamma -monomethyl-L-arginine, uric acid, and deferoxamine but not by the S-nitrosylation inhibitor DTT, indicating that tyrosine nitration is the predominant modification associated with GCK down-regulation and inactivation rather than S-nitrosylation of cysteine. Tyrosine nitration of GCK prevented its association with pBad, and GCK translocation into the mitochondria results in subsequent proteasomal degradation of GCK following ubiquitination. This study identified a novel and efficient pathway by which chronic ethanol consumption may induce GCK down-regulation and inactivation by inducing tyrosine nitration of GCK, resulting in pancreatic beta -cell apoptosis and dysfunction. Peroxynitrite-induced ATF3 may also serve as a potent upstream regulator of GCK down-regulation and beta -cell apoptosis. JF - Journal of Biological Chemistry AU - Kim, Ji Yeon AU - Song, Eun Hyun AU - Lee, Hyun Jung AU - Oh, Yeo Kyoung AU - Park, Yoon Shin AU - Park, Joo-Won AU - Kim, Bong Jo AU - Kim, Dae Jin AU - Lee, Inkyu AU - Song, Jihyun AU - Kim, Won-Ho AD - From the Divisions of Metabolic Diseases, Intractable Diseases, and Cardiovascular Diseases, Center for Biomedical Science and the Center for Genome Science, National Institutes of Health, Eunpyeong-gu, Seoul 122-701, Korea, the Department of Psychiatry, College of Medicine, Catholic University, Seoul 122-701, Korea, and the Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu 700-721, Korea Y1 - 2010/11/26/ PY - 2010 DA - 2010 Nov 26 SP - 37251 EP - 37262 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 285 IS - 48 SN - 0021-9258, 0021-9258 KW - Toxicology Abstracts KW - Apoptosis KW - Secretion KW - Pancreas KW - Mitochondria KW - Beta cells KW - Tyrosine KW - Glucokinase KW - Homeostasis KW - Insulin KW - Risk factors KW - Activating transcription factor 3 KW - Dithiothreitol KW - Translocation KW - Glucose transporter KW - Deferoxamine KW - Uric acid KW - Ethanol KW - Peroxynitrite KW - proteasomes KW - ATP KW - Diabetes mellitus KW - ubiquitination KW - siRNA KW - Cysteine KW - Nitration KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860379078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Chronic+Ethanol+Consumption-induced+Pancreatic+beta+-Cell+Dysfunction+and+Apoptosis+through+Glucokinase+Nitration+and+Its+Down-regulation&rft.au=Kim%2C+Ji+Yeon%3BSong%2C+Eun+Hyun%3BLee%2C+Hyun+Jung%3BOh%2C+Yeo+Kyoung%3BPark%2C+Yoon+Shin%3BPark%2C+Joo-Won%3BKim%2C+Bong+Jo%3BKim%2C+Dae+Jin%3BLee%2C+Inkyu%3BSong%2C+Jihyun%3BKim%2C+Won-Ho&rft.aulast=Kim&rft.aufirst=Ji&rft.date=2010-11-26&rft.volume=285&rft.issue=48&rft.spage=37251&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Apoptosis; Pancreas; Secretion; Glucokinase; Tyrosine; Beta cells; Mitochondria; Homeostasis; Insulin; Risk factors; Activating transcription factor 3; Dithiothreitol; Glucose transporter; Translocation; Deferoxamine; Ethanol; Uric acid; Peroxynitrite; proteasomes; ATP; Diabetes mellitus; ubiquitination; siRNA; Cysteine; Nitration ER - TY - JOUR T1 - Evaluation on the performance of four different column models mounted on the compact type-I coil planet centrifuge AN - 849483114; 14023722 AB - Optimal positions of coiled separation columns on the type-I centrifuge were determined for four typical two-phase solvent systems to obtain the best separation efficiency (resolution and retention of stationary phase) for each with a suitable set of test samples. A set of short coiled columns is connected in series and mounted around the holder hub in four different ways: (model A) the tail of one unit with left-handedness was connected to the head of the next unit with right-handedness (TL-HR); (model B) the tail of one unit with left-handedness was connected to the tail of the next unit with right-handedness (TL-TR); (model C) the tail of one unit with left-handedness was connected to the tail of the next unit with left-handedness (TL-TL); (model D) the tail of one unit with left-handedness was connected to the head of the next unit with left-handedness (TL-HL). The results indicated that the performance of model D was the best among the four models. High revolution speed (800 rpm) is favorable to separation using the moderately hydrophobic solvent system of hexane-ethyl acetate-methanol-0.1 M HCl (1:1:1:1, v/v) (HEMW), while lower revolution speed (600 rpm) is beneficial to the separation with polar solvent system of 1-butanol-acetic acid-water (19:1:20, v/v) (BAW). JF - Journal of Chromatography A AU - Yang, Yi AU - Gu, Dongyu AU - Aisa, Haji Akber AU - Ito, Yoichiro AD - Bioseparation Technology Laboratory, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 8N230, Bethesda, MD 20892-1762, USA, itoy2@mail.nih.gov Y1 - 2010/11/26/ PY - 2010 DA - 2010 Nov 26 SP - 7612 EP - 7615 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1217 IS - 48 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - Compact type-I coil planet centrifuge KW - Counter-current chromatography KW - Mounted column models KW - DNP-amino acids KW - Dipeptides KW - Retention of the stationary phase KW - Resolution KW - Testing Procedures KW - Chromatographic techniques KW - Solvents KW - Retention KW - Model Studies KW - Evaluation KW - Performance Evaluation KW - Centrifuges KW - Planning KW - Modelling KW - Q5 08502:Methods and instruments KW - SW 0540:Properties of water KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849483114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Evaluation+on+the+performance+of+four+different+column+models+mounted+on+the+compact+type-I+coil+planet+centrifuge&rft.au=Yang%2C+Yi%3BGu%2C+Dongyu%3BAisa%2C+Haji+Akber%3BIto%2C+Yoichiro&rft.aulast=Yang&rft.aufirst=Yi&rft.date=2010-11-26&rft.volume=1217&rft.issue=48&rft.spage=7612&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2010.10.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Chromatographic techniques; Centrifuges; Planning; Solvents; Modelling; Testing Procedures; Evaluation; Performance Evaluation; Retention; Model Studies DO - http://dx.doi.org/10.1016/j.chroma.2010.10.012 ER - TY - JOUR T1 - Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class. AN - 815555453; 21033665 AB - Here we describe a novel caged form of the highly reactive bioeffector molecule, nitroxyl (HNO). Reacting the labile nitric oxide (NO)- and HNO-generating salt of structure iPrHN-N(O)═NO(-)Na(+) (1, IPA/NO) with BrCH(2)OAc produced a stable derivative of structure iPrHN-N(O)═NO-CH(2)OAc (2, AcOM-IPA/NO), which hydrolyzed an order of magnitude more slowly than 1 at pH 7.4 and 37 °C. Hydrolysis of 2 to generate HNO proceeded by at least two mechanisms. In the presence of esterase, straightforward dissociation to acetate, formaldehyde, and 1 was the dominant path. In the absence of enzyme, free 1 was not observed as an intermediate and the ratio of NO to HNO among the products approached zero. To account for this surprising result, we propose a mechanism in which base-induced removal of the N-H proton of 2 leads to acetyl group migration from oxygen to the neighboring nitrogen, followed by cleavage of the resulting rearrangement product to isopropanediazoate ion and the known HNO precursor, CH(3)-C(O)-NO. The trappable yield of HNO from 2 was significantly enhanced over 1 at physiological pH, in part because the slower rate of hydrolysis for 2 generated a correspondingly lower steady-state concentration of HNO, thus, minimizing self-consumption and enhancing trapping by biological targets such as metmyoglobin and glutathione. Consistent with the chemical trapping efficiency data, micromolar concentrations of prodrug 2 displayed significantly more potent sarcomere shortening effects relative to 1 on ventricular myocytes isolated from wild-type mouse hearts, suggesting that 2 may be a promising lead compound for the development of heart failure therapies. JF - Journal of the American Chemical Society AU - Andrei, Daniela AU - Salmon, Debra J AU - Donzelli, Sonia AU - Wahab, Azadeh AU - Klose, John R AU - Citro, Michael L AU - Saavedra, Joseph E AU - Wink, David A AU - Miranda, Katrina M AU - Keefer, Larry K AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, United States. Y1 - 2010/11/24/ PY - 2010 DA - 2010 Nov 24 SP - 16526 EP - 16532 VL - 132 IS - 46 KW - Azo Compounds KW - 0 KW - Nitric Oxide Donors KW - Nitrogen Oxides KW - Prodrugs KW - diazeniumdiolate KW - nitroxyl KW - GFQ4MMS07W KW - Index Medicus KW - Molecular Structure KW - Animals KW - Mice KW - Muscle Cells -- metabolism KW - Muscle Cells -- chemistry KW - Magnetic Resonance Spectroscopy KW - Prodrugs -- chemistry KW - Azo Compounds -- chemistry KW - Nitrogen Oxides -- chemistry KW - Nitric Oxide Donors -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815555453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Dual+mechanisms+of+HNO+generation+by+a+nitroxyl+prodrug+of+the+diazeniumdiolate+%28NONOate%29+class.&rft.au=Andrei%2C+Daniela%3BSalmon%2C+Debra+J%3BDonzelli%2C+Sonia%3BWahab%2C+Azadeh%3BKlose%2C+John+R%3BCitro%2C+Michael+L%3BSaavedra%2C+Joseph+E%3BWink%2C+David+A%3BMiranda%2C+Katrina+M%3BKeefer%2C+Larry+K&rft.aulast=Andrei&rft.aufirst=Daniela&rft.date=2010-11-24&rft.volume=132&rft.issue=46&rft.spage=16526&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=1520-5126&rft_id=info:doi/10.1021%2Fja106552p LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-08 N1 - Date created - 2010-11-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nitric Oxide. 2001 Jun;5(3):278-87 [11384201] Dalton Trans. 2010 Jun 14;39(22):5203-12 [20502824] Nitric Oxide. 2001 Aug;5(4):395-401 [11485377] Proc Natl Acad Sci U S A. 2002 May 28;99(11):7340-5 [12032284] J Am Chem Soc. 2003 Feb 12;125(6):1444-5 [12568581] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):4978-80 [12704227] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5537-42 [12704230] Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9196-201 [12865500] Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2264-76 [12855429] J Med Chem. 2004 Jul 1;47(14):3495-501 [15214777] Free Radic Biol Med. 2004 Sep 15;37(6):735-6 [15304248] J Am Chem Soc. 2004 Oct 13;126(40):12880-7 [15469285] Bioorg Med Chem Lett. 2004 Nov 15;14(22):5565-8 [15482925] J Med Chem. 1991 Nov;34(11):3242-7 [1956043] Biochem Biophys Res Commun. 1992 Sep 30;187(3):1367-73 [1417812] J Med Chem. 1992 Oct 2;35(20):3648-52 [1433175] Biochem Pharmacol. 1993 May 25;45(10):2129-34 [8512594] J Med Chem. 1995 May 26;38(11):1865-71 [7783118] Cell Calcium. 2005 Jan;37(1):87-96 [15541467] J Am Chem Soc. 2005 Apr 20;127(15):5388-95 [15826177] Bioorg Med Chem Lett. 2005 May 2;15(9):2331-4 [15837319] Chem Rev. 2005 Jun;105(6):2439-55 [15941218] Curr Top Med Chem. 2005;5(7):649-64 [16101426] Curr Top Med Chem. 2005;5(7):665-73 [16101427] J Med Chem. 2005 Dec 29;48(26):8220-8 [16366603] Inorg Chem. 2006 Mar 20;45(6):2448-56 [16529464] J Am Chem Soc. 2006 Aug 2;128(30):9687-92 [16866522] Cardiovasc Res. 2007 Feb 1;73(3):587-96 [17189622] Pharmacol Ther. 2007 Feb;113(2):442-58 [17222913] Free Radic Biol Med. 2007 Feb 15;42(4):482-91 [17275680] Hypertension. 2007 Apr;49(4):885-92 [17309955] Neurochem Int. 2007 Nov-Dec;51(6-7):424-32 [17543420] Chem Res Toxicol. 2007 Nov;20(11):1693-700 [17907787] Methods Enzymol. 2008;440:411-31 [18423233] Circ Res. 2009 Mar 27;104(6):720-3 [19265039] Org Biomol Chem. 2009 May 7;7(9):1954-62 [19590793] J Am Chem Soc. 2001 Jan 17;123(2):285-93 [11456515] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ja106552p ER - TY - JOUR T1 - Second Malignancy Risks After Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia: Differences by Lymphoma Subtype AN - 954606480; 14104669 AB - PURPOSE: Previous studies have shown increased risks of second malignancies after non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL); however, no earlier investigation has quantified differences in risk of new malignancy by lymphoma subtype. PATIENTS AND METHODS: We evaluated second cancer and leukemia risks among 43,145 1-year survivors of CLL/small lymphocytic lymphoma (SLL), diffuse large B-cell lymphoma (DLBCL), or follicular lymphoma (FL) from 11 Surveillance, Epidemiology, and End Results (SEER) population-based registries during 1992 to 2006. RESULTS: Among patients without HIV/AIDS-related lymphoma, lung cancer risks were significantly elevated after CLL/SLL and FL but not after DLBCL (standardized incidence ratio [SIR], CLL/SLL = 1.42, FL = 1.28, DLBCL = 1.00; Poisson regression P for difference among subtypes, PDiff = .001). A similar pattern was observed for risk of cutaneous melanoma (SIR: CLL/SLL = 1.92, FL = 1.60, DLBCL = 1.06; PDiff = .004). Acute nonlymphocytic leukemia risks were significantly elevated after FL and DLBCL, particularly among patients receiving initial chemotherapy, but not after CLL/SLL (SIR: CLL/SLL = 1.13, FL = 5.96, DLBCL = 4.96; PDiff < .001). Patients with HIV/AIDS-related lymphoma (n = 932) were predominantly diagnosed with DLBCL and had significantly and substantially elevated risks for second anal cancer (SIR = 120.50) and Kaposi's sarcoma (SIR = 138.90). CONCLUSION: Our findings suggest that differing immunologic alterations, treatments (eg, alkylating agent chemotherapy), genetic susceptibilities, and other risk factors (eg, viral infections, tobacco use) among lymphoma subtypes contribute to the patterns of second malignancy risk. Elucidating these patterns may provide etiologic clues to lymphoma as well as to the second malignancies. JF - Journal of Clinical Oncology AU - Morton, Lindsay M AU - Curtis, Rochelle E AU - Linet, Martha S AU - Bluhm, Elizabeth C AU - Tucker, Margaret A AU - Caporaso, Neil AU - Ries, Lynn AG AU - Fraumeni, Joseph F AD - From the Divisions of Cancer Epidemiology and Genetics, Rockville, MD, and of Cancer Control and Population Sciences, Bethesda, MD, National Cancer Institute, National Institutes of Health, Department of Health and Human Services Y1 - 2010/11/20/ PY - 2010 DA - 2010 Nov 20 SP - 4935 EP - 4944 PB - American Society of Clinical Oncology VL - 28 IS - 33 SN - 0732-183X, 0732-183X KW - Immunology Abstracts; Toxicology Abstracts KW - Alkylating agents KW - B-cell lymphoma KW - double prime B-cell lymphoma KW - Chemotherapy KW - Melanoma KW - Non-Hodgkin's lymphoma KW - Malignancy KW - Epidemiology KW - Kaposi's sarcoma KW - Human immunodeficiency virus KW - Risk factors KW - Tobacco KW - Chronic lymphatic leukemia KW - Lung cancer KW - X 24380:Social Poisons & Drug Abuse KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954606480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Oncology&rft.atitle=Second+Malignancy+Risks+After+Non-Hodgkin%27s+Lymphoma+and+Chronic+Lymphocytic+Leukemia%3A+Differences+by+Lymphoma+Subtype&rft.au=Morton%2C+Lindsay+M%3BCurtis%2C+Rochelle+E%3BLinet%2C+Martha+S%3BBluhm%2C+Elizabeth+C%3BTucker%2C+Margaret+A%3BCaporaso%2C+Neil%3BRies%2C+Lynn+AG%3BFraumeni%2C+Joseph+F&rft.aulast=Morton&rft.aufirst=Lindsay&rft.date=2010-11-20&rft.volume=28&rft.issue=33&rft.spage=4935&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Alkylating agents; B-cell lymphoma; double prime B-cell lymphoma; Chemotherapy; Melanoma; Non-Hodgkin's lymphoma; Malignancy; Kaposi's sarcoma; Epidemiology; Risk factors; Tobacco; Chronic lymphatic leukemia; Lung cancer; Human immunodeficiency virus ER - TY - JOUR T1 - Src Homology 3-interacting Domain of Rv1917c of Mycobacterium tuberculosis Induces Selective Maturation of Human Dendritic Cells by Regulating PI3K-MAPK-NF- Kappa B Signaling and Drives Th2 Immune Responses AN - 872125371; 14104599 AB - Mycobacterium tuberculosis, an etiological agent of pulmonary tuberculosis, causes significant morbidity and mortality worldwide. Pathogenic mycobacteria survive in the host by subverting host innate immunity. Dendritic cells (DCs) are professional antigen-presenting cells that are vital for eliciting immune responses to infectious agents, including pathogenic mycobacteria. DCs orchestrate distinct Th responses based on the signals they receive. In this perspective, deciphering the interactions of the proline-glutamic acid/proline-proline-glutamic acid (PE/PPE) family of proteins of M. tuberculosis with DCs assumes significant pathophysiological attributes. In this study, we demonstrate that Rv1917c (PPE34), a representative member of the proline-proline-glutamic-major polymorphic tandem repeat family, interacts with TLR2 and triggers functional maturation of human DCs. Signaling perturbations implicated a critical role for integrated cross-talk among PI3K-MAPK and NF- Kappa B signaling cascades in Rv1917c-induced maturation of DCs. However, this maturation of DCs was associated with a secretion of high amounts of anti-inflammatory cytokine IL-10, whereas Th1-polarizing cytokine IL-12 was not induced. Consistent with these results, Rv1917c-matured DCs favored secretion of IL-4, IL-5, and IL-10 from CD4+ T cells and contributed to Th2-skewed cytokine balance ex vivo in healthy individuals and in patients with pulmonary tuberculosis. Interestingly, the Rv1917c-skewed Th2 immune response involved induced expression of cyclooxygenase-2 (COX-2) in DCs. Taken together, these results indicate that Rv1917c facilitates a shift in the ensuing immunity toward the Th2 phenotype and could aid in immune evasion by mycobacteria. JF - Journal of Biological Chemistry AU - Bansal, Kushagra AU - Sinha, Akhauri Yash AU - Ghorpade, Devram Sampat AU - Togarsimalemath, Shambhuprasad Kotresh AU - Patil, Shripad A AU - Kaveri, Srini V AU - Balaji, Kithiganahalli Narayanaswamy AU - Bayry, Jagadeesh AD - From the Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India, the Department of Microbiology, National Institute of Mental Health and Neurosciences, Bangalore, India, INSERM Unite 872, F-75006 Paris, France, the Centre de Recherche des Cordeliers, Unite Mixte de Recherche-Sante 872, Equipe 16-Immunopathology and Therapeutic Immunointervention, Universite Pierre et Marie Curie-Paris 6, F-75006 Paris, France, and the Unite Mixte de Recherche-Sante 872, Universite Paris Descartes, F-75006 Paris, France Y1 - 2010/11/19/ PY - 2010 DA - 2010 Nov 19 SP - 36511 EP - 36522 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 285 IS - 47 SN - 0021-9258, 0021-9258 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Cyclooxygenase-2 KW - Mortality KW - Interleukin 4 KW - Interleukin 5 KW - Helper cells KW - TLR2 protein KW - Interleukin 10 KW - Morbidity KW - NF- Kappa B protein KW - Inflammation KW - Dendritic cells KW - Interleukin 12 KW - CD4 antigen KW - Homology KW - Lung KW - Lymphocytes T KW - Src protein KW - Tuberculosis KW - Antigen-presenting cells KW - Toll-like receptors KW - Mycobacterium tuberculosis KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872125371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Src+Homology+3-interacting+Domain+of+Rv1917c+of+Mycobacterium+tuberculosis+Induces+Selective+Maturation+of+Human+Dendritic+Cells+by+Regulating+PI3K-MAPK-NF-+Kappa+B+Signaling+and+Drives+Th2+Immune+Responses&rft.au=Bansal%2C+Kushagra%3BSinha%2C+Akhauri+Yash%3BGhorpade%2C+Devram+Sampat%3BTogarsimalemath%2C+Shambhuprasad+Kotresh%3BPatil%2C+Shripad+A%3BKaveri%2C+Srini+V%3BBalaji%2C+Kithiganahalli+Narayanaswamy%3BBayry%2C+Jagadeesh&rft.aulast=Bansal&rft.aufirst=Kushagra&rft.date=2010-11-19&rft.volume=285&rft.issue=47&rft.spage=36511&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Cyclooxygenase-2; Mortality; Interleukin 4; Interleukin 5; Helper cells; TLR2 protein; Morbidity; Interleukin 10; Inflammation; NF- Kappa B protein; Interleukin 12; Dendritic cells; CD4 antigen; Homology; Lung; Src protein; Lymphocytes T; Tuberculosis; Antigen-presenting cells; Toll-like receptors; Mycobacterium tuberculosis ER - TY - JOUR T1 - Polymorphic C-terminal beta-sheet interactions determine the formation of fibril or amyloid beta-derived diffusible ligand-like globulomer for the Alzheimer Abeta42 dodecamer. AN - 787047361; 20847046 AB - The relationship between amyloid deposition and cellular toxicity is still controversial. In addition to fibril-forming oligomers, other soluble Aβ forms (amyloid β-derived diffusible ligands (ADDLs)) were also suggested to form and to present different morphologies and mechanisms of toxicity. One ADDL type, the "globulomer," apparently forms independently of the fibril aggregation pathway. Even though many studies argue that such soluble Aβ oligomers are off fibril formation pathways, they may nonetheless share some structural similarity with protofibrils. NMR data of globulomer intermediates, "preglobulomers," suggested parallel in-register C-terminal β-sheets, with different N-terminal conformations. Based on experimental data, we computationally investigate four classes of Aβ dodecamers: fibril, fibril oligomer, prefibril/preglobulomer cluster, and globulomer models. Our simulations of the solvent protection of double-layered fibril and globulomer models reproduce experimental observations. Using a single layer Aβ fibril oligomer β-sheet model, we found that the C-terminal β-sheet in the fibril oligomer is mostly curved, preventing it from quickly forming a fibril and leading to its breaking into shorter pieces. The simulations also indicate that β-sheets packed orthogonally could be the most stable species for Aβ dodecamers. The major difference between fibril-forming oligomers and ADDL-like oligomers (globulomers) could be the exposure of Met-35 patches. Although the Met-35 patches are necessarily exposed in fibril-forming oligomers to allow their maturation into fibrils, the Met-35 patches in the globulomer are covered by other residues in the orthogonally packed Aβ peptides. Our results call attention to the possible existence of certain "critical intermediates" that can lead to both seeds and other soluble ADDL-like oligomers. JF - The Journal of biological chemistry AU - Ma, Buyong AU - Nussinov, Ruth AD - Basic Science Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, National Cancer Institute, Frederick, Maryland 21702, USA. mabuyong@mail.nih.gov Y1 - 2010/11/19/ PY - 2010 DA - 2010 Nov 19 SP - 37102 EP - 37110 VL - 285 IS - 47 KW - Amyloid beta-Peptides KW - 0 KW - Index Medicus KW - Protein Structure, Secondary KW - Models, Molecular KW - Humans KW - Molecular Dynamics Simulation KW - Monte Carlo Method KW - Neurofibrillary Tangles -- metabolism KW - Amyloid beta-Peptides -- metabolism KW - Plaque, Amyloid -- metabolism KW - Amyloid beta-Peptides -- chemistry KW - Plaque, Amyloid -- chemistry KW - Neurofibrillary Tangles -- chemistry KW - Protein Multimerization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/787047361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Polymorphic+C-terminal+beta-sheet+interactions+determine+the+formation+of+fibril+or+amyloid+beta-derived+diffusible+ligand-like+globulomer+for+the+Alzheimer+Abeta42+dodecamer.&rft.au=Ma%2C+Buyong%3BNussinov%2C+Ruth&rft.aulast=Ma&rft.aufirst=Buyong&rft.date=2010-11-19&rft.volume=285&rft.issue=47&rft.spage=37102&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M110.133488 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-28 N1 - Date created - 2010-11-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Protein Sci. 2006 Mar;15(3):420-8 [16501222] Biochemistry. 2006 Jan 17;45(2):498-512 [16401079] Biochemistry. 2006 May 2;45(17):5503-16 [16634632] Biochem J. 2007 May 15;404(1):63-70 [17280549] Biophys J. 2007 Sep 15;93(6):1938-49 [17526580] Biophys J. 2007 Nov 1;93(9):3046-57 [17675353] Trends Biochem Sci. 2008 Feb;33(2):91-100 [18182298] J Mol Biol. 2008 Mar 21;377(2):565-74 [18258258] Neurobiol Dis. 2008 May;30(2):212-20 [18353662] Biophys J. 2008 Nov 15;95(10):4631-42 [18708452] Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18349-54 [19015532] Anal Biochem. 2009 Feb 15;385(2):374-6 [19027706] Chembiochem. 2009 Jan 26;10(2):287-95 [19115328] Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4653-8 [19264960] Biochemistry. 2009 Mar 10;48(9):1870-7 [19216516] Biophys J. 2009 Aug 19;97(4):1168-77 [19686665] J Am Chem Soc. 2009 Oct 21;131(41):14938-45 [19824733] J Biol Chem. 2009 Nov 20;284(47):32895-905 [19759000] Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19813-8 [19843697] Free Radic Biol Med. 2010 Jan 1;48(1):136-44 [19854267] J Biol Chem. 2010 Feb 26;285(9):6071-9 [20018889] Neurochem Int. 2010 Mar;56(4):597-602 [20060866] Nat Struct Mol Biol. 2010 May;17(5):561-7 [20383142] Chem Rev. 2010 Aug 11;110(8):4820-38 [20402519] Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14128-33 [20660780] Nat Struct Mol Biol. 2007 Dec;14(12):1157-64 [18059284] J Biol Chem. 2006 Jan 6;281(1):477-83 [16215229] Neurobiol Aging. 2002 Mar-Apr;23(2):231-5 [11804707] Biochim Biophys Acta. 2002 Mar 16;1586(2):190-8 [11959460] Peptides. 2002 Jul;23(7):1299-309 [12128086] Science. 2002 Jul 19;297(5580):353-6 [12130773] J Neurosci Res. 2002 Sep 1;69(5):567-77 [12210822] Protein Sci. 2002 Oct;11(10):2335-50 [12237456] Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14126-31 [12391326] Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16742-7 [12481027] Science. 2003 Apr 18;300(5618):486-9 [12702875] Proc Natl Acad Sci U S A. 2003 May 27;100(11):6370-5 [12750461] J Mol Biol. 2004 Jan 2;335(1):247-60 [14659754] J Am Chem Soc. 2003 Dec 17;125(50):15359-65 [14664580] J Biol Chem. 2004 Apr 9;279(15):14999-5013 [14736893] Protein Pept Lett. 2004 Jun;11(3):213-28 [15182223] Mol Cell Biochem. 1994 Nov 23;140(2):119-25 [7898484] Proc Natl Acad Sci U S A. 1998 May 26;95(11):6448-53 [9600986] Nat Med. 1998 Jul;4(7):832-4 [9662376] Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12277-82 [9770477] Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):9970-2 [10468538] Protein Eng. 1999 Sep;12(9):713-20 [10506280] Science. 2005 Jan 14;307(5707):262-5 [15653506] J Comput Chem. 2005 Dec;26(16):1781-802 [16222654] J Neurochem. 2005 Nov;95(3):834-47 [16135089] Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17342-7 [16293696] Nature. 2006 Mar 16;440(7082):352-7 [16541076] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M110.133488 ER - TY - JOUR T1 - Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19 AN - 954611684; 14103827 AB - Adoptive transfer of genetically modified T cells is an attractive approach for generating antitumor immune responses. We treated a patient with advanced follicular lymphoma by administering a preparative chemotherapy regimen followed by autologous T cells genetically engineered to express a chimeric antigen receptor (CAR) that recognized the B-cell antigen CD19. The patient's lymphoma underwent a dramatic regression, and B-cell precursors were selectively eliminated from the patient's bone marrow after infusion of anti-CD19-CAR-transduced T cells. Blood B cells were absent for at least 39 weeks after anti-CD19-CAR-transduced T-cell infusion despite prompt recovery of other blood cell counts. Consistent with eradication of B-lineage cells, serum immunoglobulins decreased to very low levels after treatment. The prolonged and selective elimination of B-lineage cells could not be attributed to the chemotherapy that the patient received and indicated antigen-specific eradication of B-lineage cells. Adoptive transfer of anti-CD19-CAR-expressing T cells is a promising new approach for treating B-cell malignancies. This study is registered at www.clinicaltrials.gov as #NCT00924326. JF - Blood AU - Kochenderfer, James N AU - Wilson, Wyndham H AU - Janik, John E AU - Dudley, Mark E AU - Stetler-Stevenson, Maryalice AU - Feldman, Steven A AU - Maric, Irina AU - Raffeld, Mark AU - Nathan, Debbie-Ann N AU - Lanier, Brock J AU - Morgan, Richard A AU - Rosenberg, Steven A AD - Surgery Branch, Metabolism Branch, and Laboratory of Pathology, National Cancer Institute, Bethesda, MD Y1 - 2010/11/18/ PY - 2010 DA - 2010 Nov 18 SP - 4099 EP - 4102 PB - The American Society of Hematology VL - 116 IS - 20 SN - 1528-0020, 1528-0020 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Autografts KW - Lymphocytes B KW - Chemotherapy KW - Bone marrow KW - Malignancy KW - Genetic engineering KW - Adoptive transfer KW - Lymphocytes T KW - Blood cells KW - Lymphoma KW - Immunoglobulins KW - Antitumor activity KW - CD19 antigen KW - W 30915:Pharmaceuticals & Vaccines KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954611684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Eradication+of+B-lineage+cells+and+regression+of+lymphoma+in+a+patient+treated+with+autologous+T+cells+genetically+engineered+to+recognize+CD19&rft.au=Kochenderfer%2C+James+N%3BWilson%2C+Wyndham+H%3BJanik%2C+John+E%3BDudley%2C+Mark+E%3BStetler-Stevenson%2C+Maryalice%3BFeldman%2C+Steven+A%3BMaric%2C+Irina%3BRaffeld%2C+Mark%3BNathan%2C+Debbie-Ann+N%3BLanier%2C+Brock+J%3BMorgan%2C+Richard+A%3BRosenberg%2C+Steven+A&rft.aulast=Kochenderfer&rft.aufirst=James&rft.date=2010-11-18&rft.volume=116&rft.issue=20&rft.spage=4099&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=15280020&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Autografts; Lymphocytes B; Chemotherapy; Bone marrow; Malignancy; Genetic engineering; Lymphocytes T; Adoptive transfer; Blood cells; Lymphoma; CD19 antigen; Antitumor activity; Immunoglobulins ER - TY - JOUR T1 - Cancer Pharmacogenomics and Pharmacoepidemiology: Setting a Research Agenda to Accelerate Translation AN - 954607376; 14104964 AB - Recent advances in genomic research have demonstrated a substantial role for genomic factors in predicting response to cancer therapies. Researchers in the fields of cancer pharmacogenomics and pharmacoepidemiology seek to understand why individuals respond differently to drug therapy, in terms of both adverse effects and treatment efficacy. To identify research priorities as well as the resources and infrastructure needed to advance these fields, the National Cancer Institute (NCI) sponsored a workshop titled "Cancer Pharmacogenomics: Setting a Research Agenda to Accelerate Translation" on July 21, 2009, in Bethesda, MD. In this commentary, we summarize and discuss five science-based recommendations and four infrastructure-based recommendations that were identified as a result of discussions held during this workshop. Key recommendations include 1) supporting the routine collection of germline and tumor biospecimens in NCI-sponsored clinical trials and in some observational and population-based studies; 2) incorporating pharmacogenomic markers into clinical trials; 3) addressing the ethical, legal, social, and biospecimen- and data-sharing implications of pharmacogenomic and pharmacoepidemiologic research; and 4) establishing partnerships across NCI, with other federal agencies, and with industry. Together, these recommendations will facilitate the discovery and validation of clinical, sociodemographic, lifestyle, and genomic markers related to cancer treatment response and adverse events, and they will improve both the speed and efficiency by which new pharmacogenomic and pharmacoepidemiologic information is translated into clinical practice. JF - Journal of the National Cancer Institute AU - Freedman, Andrew N AU - Sansbury, Leah B AU - Figg, William D AU - Potosky, Arnold L AU - Weiss Smith, Sheila R AU - Khoury, Muin J AU - Nelson, Stefanie A AU - Weinshilboum, Richard M AU - Ratain, Mark J AU - McLeod, Howard L AU - Epstein, Robert S AU - Ginsburg, Geoffrey S AU - Schilsky, Richard L AU - Liu, Geoffrey AU - Flockhart, David A AU - Ulrich, Cornelia M AU - Davis, Robert L AU - Lesko, Lawrence J AU - Zineh, Issam AU - Randhawa, Gurvaneet AU - Ambrosone, Christine B AU - Relling, Mary V AU - Rothman, Nat AU - Xie, Heng AU - Spitz, Margaret R AU - Ballard-Barbash, Rachel AU - Doroshow, James H AU - Minasian, Lori M AD - Division of Cancer Control and Population Sciences (ANF, LBS, SAN, RB-B), Medical Oncology Branch, Center for Cancer Research (WDF), Division of Cancer Epidemiology and Genetics (NR), Division of Cancer Treatment and Diagnosis (JHD), and Division of Cancer Prevention, National Cancer Institute, Bethesda, MD (LMM) Y1 - 2010/11/17/ PY - 2010 DA - 2010 Nov 17 SP - 1698 EP - 1705 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 22 SN - 0027-8874, 0027-8874 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Translation KW - Conferences KW - pharmacogenomics KW - Ethics KW - Reviews KW - Population studies KW - genomics KW - Tumors KW - Clinical trials KW - Cancer KW - Side effects KW - G 07880:Human Genetics KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954607376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Cancer+Pharmacogenomics+and+Pharmacoepidemiology%3A+Setting+a+Research+Agenda+to+Accelerate+Translation&rft.au=Freedman%2C+Andrew+N%3BSansbury%2C+Leah+B%3BFigg%2C+William+D%3BPotosky%2C+Arnold+L%3BWeiss+Smith%2C+Sheila+R%3BKhoury%2C+Muin+J%3BNelson%2C+Stefanie+A%3BWeinshilboum%2C+Richard+M%3BRatain%2C+Mark+J%3BMcLeod%2C+Howard+L%3BEpstein%2C+Robert+S%3BGinsburg%2C+Geoffrey+S%3BSchilsky%2C+Richard+L%3BLiu%2C+Geoffrey%3BFlockhart%2C+David+A%3BUlrich%2C+Cornelia+M%3BDavis%2C+Robert+L%3BLesko%2C+Lawrence+J%3BZineh%2C+Issam%3BRandhawa%2C+Gurvaneet%3BAmbrosone%2C+Christine+B%3BRelling%2C+Mary+V%3BRothman%2C+Nat%3BXie%2C+Heng%3BSpitz%2C+Margaret+R%3BBallard-Barbash%2C+Rachel%3BDoroshow%2C+James+H%3BMinasian%2C+Lori+M&rft.aulast=Freedman&rft.aufirst=Andrew&rft.date=2010-11-17&rft.volume=102&rft.issue=22&rft.spage=1698&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Translation; Conferences; pharmacogenomics; Reviews; Ethics; Population studies; Tumors; genomics; Clinical trials; Side effects; Cancer ER - TY - JOUR T1 - Lobular Involution, Mammographic Density, and Breast Cancer Risk: Visualizing the Future? AN - 904465070; 14104969 JF - Journal of the National Cancer Institute AU - Gierach, Gretchen L AU - Brinton, Louise A AU - Sherman, Mark E AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD (GLG, LAB, MES) Y1 - 2010/11/17/ PY - 2010 DA - 2010 Nov 17 SP - 1685 EP - 1687 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 22 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Breast cancer KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904465070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Lobular+Involution%2C+Mammographic+Density%2C+and+Breast+Cancer+Risk%3A+Visualizing+the+Future%3F&rft.au=Gierach%2C+Gretchen+L%3BBrinton%2C+Louise+A%3BSherman%2C+Mark+E&rft.aulast=Gierach&rft.aufirst=Gretchen&rft.date=2010-11-17&rft.volume=102&rft.issue=22&rft.spage=1685&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Breast cancer; Cancer ER - TY - JOUR T1 - Bridging the gene-behavior divide through neuroimaging deletion syndromes: Velocardiofacial (22q11.2 Deletion) and Williams (7q11.23 Deletion) syndromes AN - 876250541; 15123913 AB - Investigating the relationship between genes and the neural substrates of complex human behavior promises to provide essential insight into the pathophysiology of mental disorders. One approach to this inquiry is through neuroimaging of individuals with microdeletion syndromes that manifest in specific neuropsychiatric phenotypes. Both Velocardiofacial syndrome (VCFS) and Williams syndrome (WS) involve haploinsufficiency of a relatively small set of identified genes on the one hand and association with distinct, clinically relevant behavioral and cognitive profiles on the other hand. In VCFS, there is a deletion in chromosomal region 22q11.2 and a resultant predilection toward psychosis, poor arithmetic proficiency, and low performance intelligence quotients. In WS, there is a deletion in chromosomal region 7q11.23 and a resultant predilection toward hypersociability, non-social anxiety, impaired visuospatial construction, and often intellectual impairment. Structural and functional neuroimaging studies have begun not only to map these well-defined genetic alterations to systems-level brain abnormalities, but also to identify relationships between neural phenotypes and particular genes within the critical deletion regions. Though neuroimaging of both VCFS and WS presents specific, formidable methodological challenges, including comparison subject selection and accounting for neuroanatomical and vascular anomalies in patients, and many questions remain, the literature to date on these syndromes, reviewed herein, constitutes a fruitful "bottom-up" approach to defining gene-brain relationships. JF - NeuroImage AU - Eisenberg, Daniel Paul AU - Jabbi, Mbemba AU - Berman, Karen Faith AD - Section on Integrative Neuroimaging, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program National Institute of Mental Health, NIH, Intramural Research Program, DHHS, Bethesda MD 20892, USA, bermank@mail.nih.gov Y1 - 2010/11/15/ PY - 2010 DA - 2010 Nov 15 SP - 857 EP - 869 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 53 IS - 3 SN - 1053-8119, 1053-8119 KW - Genetics Abstracts; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Anatomy KW - Neuroimaging KW - W 30910:Imaging KW - N3:11001 KW - G:07880 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876250541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Bridging+the+gene-behavior+divide+through+neuroimaging+deletion+syndromes%3A+Velocardiofacial+%2822q11.2+Deletion%29+and+Williams+%287q11.23+Deletion%29+syndromes&rft.au=Eisenberg%2C+Daniel+Paul%3BJabbi%2C+Mbemba%3BBerman%2C+Karen+Faith&rft.aulast=Eisenberg&rft.aufirst=Daniel&rft.date=2010-11-15&rft.volume=53&rft.issue=3&rft.spage=857&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.02.070 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Neuroimaging DO - http://dx.doi.org/10.1016/j.neuroimage.2010.02.070 ER - TY - JOUR T1 - Imaging genetics of structural brain connectivity and neural integrity markers AN - 876239306; 15123846 AB - We review studies that have used diffusion imaging (DI) and magnetic resonance spectroscopy (MRS) to investigate genetic associations. A brief description of the measures obtainable with these methods and of some methodological and interpretability limitations is given. The usefulness of di and MRS in defining intermediate phenotypes and in demonstrating the effects of common genetic variants known to increase risk for psychiatric manifestations on anatomical and metabolic phenotypes is reviewed. The main focus is on schizophrenia where the greatest amount of data has been collected. Moreover, we present an example coming from a different approach, where the genetic alteration is known (the deletion that causes Williams syndrome) and the di phenotype can shed new light on the function of genes affected by the mutation. We conclude that, although these are still early days of this type of research and many findings remain controversial, both techniques can significantly contribute to the understanding of genetic effects in the brain and the pathophysiology of psychiatric disorders. JF - NeuroImage AU - Marenco, Stefano AU - Radulescu, Eugenia AD - Unit for Multimodal Imaging Genetics, Clinical Brain Disorders Branch, GCAP, IRP, NIMH, 10 Center Drive, Building 10, Room 3C103, Bethesda, MD 20892, USA, marencos@mail.nih.gov Y1 - 2010/11/15/ PY - 2010 DA - 2010 Nov 15 SP - 848 EP - 856 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 53 IS - 3 SN - 1053-8119, 1053-8119 KW - Genetics Abstracts; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain KW - Neuroimaging KW - W 30910:Imaging KW - N3:11001 KW - G:07880 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876239306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Imaging+genetics+of+structural+brain+connectivity+and+neural+integrity+markers&rft.au=Marenco%2C+Stefano%3BRadulescu%2C+Eugenia&rft.aulast=Marenco&rft.aufirst=Stefano&rft.date=2010-11-15&rft.volume=53&rft.issue=3&rft.spage=848&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.11.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Neuroimaging DO - http://dx.doi.org/10.1016/j.neuroimage.2009.11.030 ER - TY - JOUR T1 - Imaging genetics - days of future past AN - 876231285; 15123900 AB - Imaging genetics provides a unique tool with which to explore and evaluate the functional impact of brain-relevant genetic polymorphisms with the potential to understand their impact on behavior. Because statistical association with clinical diagnosis does not establish biological significance nor identify a mechanism of risk, imaging genetics is a uniquely valuable strategy for extending statistical evidence with biological data. Applications include identifying biologic mechanisms and pathways that mediate individual differences in complex behaviors and vulnerability to disease, and conversely identifying genes that contribute to functional variation in brain circuitry. Additionally, neuroimaging genetics can validate data that suggest an association with psychiatric illness as well as providing evidence of the mechanism of risk. This review also outlines several critical principles of imaging genetics including a rational approach to the selection of candidate genes, the selection of task paradigms that could be plausibly linked to the biology of the gene of interest, and careful control of non-genetic factors. The future of imaging genetics holds great promise for brain research and for biologic validation of genetic validation in CNS disorders, but a disciplined application of the basic principles outlined in this review is critical. JF - NeuroImage AU - Bigos, Kristin L AU - Weinberger, Daniel R AD - Genes Cognition and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, MSC 1379, Bethesda, MD 20892, USA, weinberd@mail.nih.gov Y1 - 2010/11/15/ PY - 2010 DA - 2010 Nov 15 SP - 804 EP - 809 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 53 IS - 3 SN - 1053-8119, 1053-8119 KW - Genetics Abstracts; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Central nervous system KW - Neuroimaging KW - G:07780 KW - W 30910:Imaging KW - N3:11001 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876231285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Imaging+genetics+-+days+of+future+past&rft.au=Bigos%2C+Kristin+L%3BWeinberger%2C+Daniel+R&rft.aulast=Bigos&rft.aufirst=Kristin&rft.date=2010-11-15&rft.volume=53&rft.issue=3&rft.spage=804&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.01.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Neuroimaging DO - http://dx.doi.org/10.1016/j.neuroimage.2010.01.035 ER - TY - JOUR T1 - Solid-phase synthesis and screening of N-acylated polyamine (NAPA) combinatorial libraries for protein binding AN - 867739731; 14779718 AB - Inhibitors for protein-protein interactions are challenging to design, in part due to the unique and complex architectures of each protein's interaction domain. Most approaches to develop inhibitors for these interactions rely on rational design, which requires prior structural knowledge of the target and its ligands. In the absence of structural information, a combinatorial approach may be the best alternative to finding inhibitors of a protein-protein interaction. Current chemical libraries, however, consist mostly of molecules designed to inhibit enzymes. In this manuscript, we report the synthesis and screening of a library based on an N-acylated polyamine (NAPA) scaffold that we designed to have specific molecular features necessary to inhibit protein-protein interactions. Screens of the library identified a member with favorable binding properties to the HIV viral protein R (Vpr), a regulatory protein from HIV, that is involved in numerous interactions with other proteins critical for viral replication. JF - Bioorganic and Medicinal Chemistry Letters AU - Iera, Jaclyn A AU - Jenkins, Lisa MMiller AU - Kajiyama, Hiroshi AU - Kopp, Jeffrey B AU - Appella, Daniel H AD - Laboratory of Bioorganic Chemistry and Kidney Disease Section, NIDDK, NIH, DHHS, Bethesda, MD 20892, United States, appellad@niddk.nih.gov Y1 - 2010/11/15/ PY - 2010 DA - 2010 Nov 15 SP - 6500 EP - 6503 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 20 IS - 22 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - regulatory proteins KW - Human immunodeficiency virus KW - polyamines KW - Replication KW - Vpr protein KW - Enzymes KW - Solid phase methods KW - Protein interaction KW - Combinatorial libraries KW - scaffolds KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867739731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Solid-phase+synthesis+and+screening+of+N-acylated+polyamine+%28NAPA%29+combinatorial+libraries+for+protein+binding&rft.au=Iera%2C+Jaclyn+A%3BJenkins%2C+Lisa+MMiller%3BKajiyama%2C+Hiroshi%3BKopp%2C+Jeffrey+B%3BAppella%2C+Daniel+H&rft.aulast=Iera&rft.aufirst=Jaclyn&rft.date=2010-11-15&rft.volume=20&rft.issue=22&rft.spage=6500&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2010.09.054 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - regulatory proteins; Replication; polyamines; Vpr protein; Enzymes; Solid phase methods; scaffolds; Combinatorial libraries; Protein interaction; Human immunodeficiency virus DO - http://dx.doi.org/10.1016/j.bmcl.2010.09.054 ER - TY - JOUR T1 - Investigating the correlations among the chemical structures, bioactivity profiles and molecular targets of small molecules AN - 849435660; 13966577 AB - MOTIVATION: Most of the previous data mining studies based on the NCI-60 dataset, due to its intrinsic cell-based nature, can hardly provide insights into the molecular targets for screened compounds. On the other hand, the abundant information of the compound-target associations in PubChem can offer extensive experimental evidence of molecular targets for tested compounds. Therefore, by taking advantages of the data from both public repositories, one may investigate the correlations between the bioactivity profiles of small molecules from the NCI-60 dataset (cellular level) and their patterns of interactions with relevant protein targets from PubChem (molecular level) simultaneously. RESULTS: We investigated a set of 37 small molecules by providing links among their bioactivity profiles, protein targets and chemical structures. Hierarchical clustering of compounds was carried out based on their bioactivity profiles. We found that compounds were clustered into groups with similar mode of actions, which strongly correlated with chemical structures. Furthermore, we observed that compounds similar in bioactivity profiles also shared similar patterns of interactions with relevant protein targets, especially when chemical structures were related. The current work presents a new strategy for combining and data mining the NCI-60 dataset and PubChem. This analysis shows that bioactivity profile comparison can provide insights into the mode of actions at the molecular level, thus will facilitate the knowledge-based discovery of novel compounds with desired pharmacological properties. JF - Bioinformatics AU - Cheng, Tiejun AU - Wang, Yanli AU - Bryant, Stephen H AD - National Center for Biotechnology Information, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA Y1 - 2010/11/15/ PY - 2010 DA - 2010 Nov 15 SP - 2881 EP - 2888 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 26 IS - 22 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Data processing KW - Bioinformatics KW - Internet KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849435660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Investigating+the+correlations+among+the+chemical+structures%2C+bioactivity+profiles+and+molecular+targets+of+small+molecules&rft.au=Cheng%2C+Tiejun%3BWang%2C+Yanli%3BBryant%2C+Stephen+H&rft.aulast=Cheng&rft.aufirst=Tiejun&rft.date=2010-11-15&rft.volume=26&rft.issue=22&rft.spage=2881&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Databases; Data processing; Bioinformatics; Internet ER - TY - JOUR T1 - lacZ Reporter System for Use in Borrelia burgdorferi AN - 839675723; 13966329 AB - Regulation of gene expression is critical for the ability of Borrelia burgdorferi to adapt to different environments during its natural infectious cycle. Reporter genes have been used successfully to study gene regulation in multiple organisms. We have introduced a lacZ gene into B. burgdorferi, and we show that B. burgdorferi produces a protein with detectable b-galactosidase activity in both liquid and solid media when lacZ is expressed from a constitutive promoter. Furthermore, when lacZ is expressed from the ospC promoter, b-galactosidase activity is detected only in B. burgdorferi clones that express ospC, and it accurately monitors endogenous gene expression. The addition of lacZ to the repertoire of genetic tools available for use in B. burgdorferi should contribute to a better understanding of how B. burgdorferi gene expression is regulated during the infectious cycle. JF - Applied and Environmental Microbiology AU - Hayes, Beth M AU - Jewett, Mollie W AU - Rosa, Patricia A AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2010/11/15/ PY - 2010 DA - 2010 Nov 15 SP - 7407 EP - 7412 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 22 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Environment Abstracts KW - Promoters KW - beta -Galactosidase KW - Borrelia burgdorferi KW - ribonuclease B KW - Gene regulation KW - Proteins KW - lacZ gene KW - J 02310:Genetics & Taxonomy KW - A 01450:Environmental Pollution & Waste Treatment KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839675723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=lacZ+Reporter+System+for+Use+in+Borrelia+burgdorferi&rft.au=Hayes%2C+Beth+M%3BJewett%2C+Mollie+W%3BRosa%2C+Patricia+A&rft.aulast=Hayes&rft.aufirst=Beth&rft.date=2010-11-15&rft.volume=76&rft.issue=22&rft.spage=7407&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Promoters; beta -Galactosidase; Gene regulation; ribonuclease B; lacZ gene; Proteins; Borrelia burgdorferi ER - TY - JOUR T1 - Development of a validated immunofluorescence assay for γH2AX as a pharmacodynamic marker of topoisomerase I inhibitor activity. AN - 815550982; 20924131 AB - Phosphorylated histone H2AX (γH2AX) serves as a biomarker for formation of DNA double-strand break repair complexes. A quantitative pharmacodynamic immunofluorescence assay for γH2AX was developed, validated, and tested in human tumor xenograft models with the use of clinically relevant procedures. The γH2AX immunofluorescence assay uses a novel data quantitation and image processing algorithm to determine the extent of nuclear-specific γH2AX staining in tumor needle biopsies and hair follicles collected from mice bearing topotecan-responsive A375 xenografts. After method validation with the topoisomerase I (Top1) inhibitor topotecan, the assay was used to compare pharmacodynamic properties of three structurally related indenoisoquinoline Top1 inhibitors. γH2AX response to topotecan was quantified over a 60-fold dose range (0.016-1.0 times the murine single-dose maximum tolerated dose), and significant pharmacodynamic response was measured at the mouse equivalent of the 1.5 mg/m(2) clinical dose as well as the lowest dose tested. Responses were within a time window amenable for biopsy collection in clinical trials. These studies enabled characterization of dose and time responses for three indenoisoquinolines, resulting in selection of two for clinical evaluation. γH2AX response to Top1 inhibitors in hair follicles was also observable above a minimal dose threshold. Our γH2AX assay is sufficiently accurate and sensitive to quantify γH2AX in tumor samples and will be used in correlative studies of two indenoisoquinolines in a phase I clinical trial at the National Cancer Institute. Data suggest that hair follicles may potentially serve as a surrogate tissue to evaluate tumor γH2AX response to Top1 inhibitors. ©2010 AACR. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Kinders, Robert J AU - Hollingshead, Melinda AU - Lawrence, Scott AU - Ji, Jiuping AU - Tabb, Brian AU - Bonner, William M AU - Pommier, Yves AU - Rubinstein, Larry AU - Evrard, Yvonne A AU - Parchment, Ralph E AU - Tomaszewski, Joseph AU - Doroshow, James H AU - National Cancer Institute Phase 0 Clinical Trials Team AD - Laboratory of Human Toxicology and Pharmacology, Applied/Developmental Research Support Directorate, Science Applications International Corporation-Frederick, Inc., NationalCancer Institute-Frederick, Frederick, MD 21702, USA. kindersr@mail.nih.gov ; National Cancer Institute Phase 0 Clinical Trials Team Y1 - 2010/11/15/ PY - 2010 DA - 2010 Nov 15 SP - 5447 EP - 5457 VL - 16 IS - 22 SN - 1078-0432, 1078-0432 KW - Biomarkers, Pharmacological KW - 0 KW - H2AFX protein, human KW - Histones KW - Topoisomerase I Inhibitors KW - DNA Topoisomerases, Type I KW - EC 5.99.1.2 KW - Index Medicus KW - Animals KW - Humans KW - Algorithms KW - Xenograft Model Antitumor Assays KW - Mice KW - Topoisomerase I Inhibitors -- pharmacology KW - Biomarkers, Pharmacological -- analysis KW - Fluorescent Antibody Technique -- methods KW - Histones -- analysis KW - DNA Topoisomerases, Type I -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815550982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Development+of+a+validated+immunofluorescence+assay+for+%CE%B3H2AX+as+a+pharmacodynamic+marker+of+topoisomerase+I+inhibitor+activity.&rft.au=Kinders%2C+Robert+J%3BHollingshead%2C+Melinda%3BLawrence%2C+Scott%3BJi%2C+Jiuping%3BTabb%2C+Brian%3BBonner%2C+William+M%3BPommier%2C+Yves%3BRubinstein%2C+Larry%3BEvrard%2C+Yvonne+A%3BParchment%2C+Ralph+E%3BTomaszewski%2C+Joseph%3BDoroshow%2C+James+H%3BNational+Cancer+Institute+Phase+0+Clinical+Trials+Team&rft.aulast=Kinders&rft.aufirst=Robert&rft.date=2010-11-15&rft.volume=16&rft.issue=22&rft.spage=5447&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-09-3076 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-17 N1 - Date created - 2010-11-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Mar 31;275(13):9390-5 [10734083] Br J Cancer. 2005 May 23;92(10):1837-41 [15886708] Nat Genet. 2001 Mar;27(3):271-6 [11242108] J Clin Oncol. 2002 May 15;20(10):2495-9 [12011127] Radiat Res. 2002 Oct;158(4):486-92 [12236816] Biol Reprod. 2003 Feb;68(2):628-34 [12533428] Curr Top Med Chem. 2003;3(3):305-20 [12570765] Radiat Res. 2003 Jun;159(6):759-67 [12751958] J Biol Chem. 2003 May 30;278(22):20303-12 [12660252] J Radiat Res. 2003 Mar;44(1):47-51 [12841599] J Med Chem. 2003 Dec 18;46(26):5712-24 [14667224] Cytometry A. 2004 Apr;58(2):99-110 [15057963] Clin Cancer Res. 2004 Jun 1;10(11):3881-4 [15173097] DNA Repair (Amst). 2004 Aug-Sep;3(8-9):959-67 [15279782] Mol Biol Rep. 1986;11(1):3-12 [3511359] J Biol Chem. 1998 Mar 6;273(10):5858-68 [9488723] Mol Pharmacol. 1998 Jul;54(1):50-8 [9658189] Dermatology. 2005;210(4):273-8 [15942212] Clin Cancer Res. 2005 Jun 15;11(12):4338-40 [15958615] Cytometry A. 2005 Nov;68(1):1-9 [16184611] J Natl Cancer Inst. 2006 May 3;98(9):580-98 [16670384] Curr Cancer Drug Targets. 2006 May;6(3):197-205 [16712457] Methods Enzymol. 2006;409:236-50 [16793405] Int J Oncol. 2006 Aug;29(2):495-501 [16820894] Nat Rev Cancer. 2006 Oct;6(10):789-802 [16990856] Cell Cycle. 2006 Dec;5(24):2909-13 [17172873] Nat Rev Cancer. 2007 Feb;7(2):131-9 [17251919] Cancer Res. 2007 Nov 1;67(21):10397-405 [17974983] Toxicol Pathol. 2007 Dec;35(7):952-7 [18098041] J Clin Oncol. 2008 Jun 1;26(16):2690-8 [18509181] Clin Cancer Res. 2008 Jun 15;14(12):3675-82 [18559582] In Vivo. 2008 May-Jun;22(3):305-9 [18610740] Clin Cancer Res. 2008 Nov 1;14(21):6877-85 [18980982] Nat Rev Cancer. 2008 Dec;8(12):957-67 [19005492] Clin Cancer Res. 2009 May 15;15(10):3344-53 [19401347] J Clin Oncol. 2009 Jun 1;27(16):2705-11 [19364967] Cell Cycle. 2009 Jun 15;8(12):1853-9 [19448405] Mol Cancer Ther. 2009 Jul;8(7):1878-84 [19584232] Clin Cancer Res. 2010 Feb 1;16(3):1073-84 [20103672] Mol Cancer Ther. 2009 May;8(5):1008-14 [19383846] J Cell Biol. 1999 Sep 6;146(5):905-16 [10477747] Mol Pharmacol. 2005 Feb;67(2):523-30 [15531731] Curr Biol. 2000 Jul 27-Aug 10;10(15):886-95 [10959836] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-09-3076 ER - TY - JOUR T1 - Eicosapentaenoic acid improves hepatic steatosis independent of PPARα activation through inhibition of SREBP-1 maturation in mice. AN - 755971665; 20691165 AB - Eicosapentaenoic acid (EPA) in fish oil is known to improve hepatic steatosis. However, it remains unclear whether such action of EPA is actually caused by peroxisome proliferator-activated receptor α (PPARα) activation. To explore the contribution of PPARα to the effects of EPA itself, male wild-type and Ppara-null mice were fed a saturated fat diet for 16 weeks, and highly (>98%)-purified EPA was administered in the last 12 weeks. Furthermore, the changes caused by EPA treatment were compared to those elicited by fenofibrate (FF), a typical PPARα activator. A saturated fat diet caused macrovesicular steatosis in both genotypes. However, EPA ameliorated steatosis only in wild-type mice without PPARα activation, which was evidently different from numerous previous observations. Instead, EPA inhibited maturation of sterol-responsive element-binding protein (SREBP)-1 in the presence of PPARα through down-regulation of SREBP cleavage-activating protein and site-1 protease. Additionally, EPA suppressed fatty acid uptake and promoted hydrolysis of intrahepatic triglycerides in a PPARα-independent manner. These effects were distinct from those of fenofibrate. Although fenofibrate induced NAPDH oxidase and acyl-coenzyme A oxidase and significantly increased hepatic lipid peroxides, EPA caused PPARα-dependent induction of superoxide dismutases, probably contributing to a decrease in the lipid peroxides. These results firstly demonstrate detailed mechanisms of steatosis-ameliorating effects of EPA without PPARα activation and ensuing augmentation of hepatic oxidative stress. Copyright © 2010 Elsevier Inc. All rights reserved. JF - Biochemical pharmacology AU - Tanaka, Naoki AU - Zhang, Xiuguo AU - Sugiyama, Eiko AU - Kono, Hiroyuki AU - Horiuchi, Akira AU - Nakajima, Takero AU - Kanbe, Hiroki AU - Tanaka, Eiji AU - Gonzalez, Frank J AU - Aoyama, Toshifumi AD - Department of Metabolic Regulation, Shinshu University Graduate School of Medicine, Japan. tanakan@mail.nih.gov Y1 - 2010/11/15/ PY - 2010 DA - 2010 Nov 15 SP - 1601 EP - 1612 VL - 80 IS - 10 KW - Dietary Fats KW - 0 KW - PPAR alpha KW - Srebf1 protein, mouse KW - Sterol Regulatory Element Binding Protein 1 KW - Eicosapentaenoic Acid KW - AAN7QOV9EA KW - Fenofibrate KW - U202363UOS KW - Index Medicus KW - Animals KW - Immunoblotting KW - Liver -- pathology KW - Lipid Peroxidation -- drug effects KW - Dietary Fats -- administration & dosage KW - Disease Models, Animal KW - Liver -- metabolism KW - Mice KW - Liver Function Tests KW - Mice, Knockout KW - Fenofibrate -- pharmacology KW - Genotype KW - Dietary Fats -- adverse effects KW - Liver -- drug effects KW - Oxidative Stress -- drug effects KW - Male KW - Sterol Regulatory Element Binding Protein 1 -- antagonists & inhibitors KW - Fatty Liver -- drug therapy KW - Fatty Liver -- etiology KW - Fatty Liver -- metabolism KW - Eicosapentaenoic Acid -- pharmacology KW - PPAR alpha -- metabolism KW - Fatty Liver -- pathology KW - Eicosapentaenoic Acid -- therapeutic use KW - PPAR alpha -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755971665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Eicosapentaenoic+acid+improves+hepatic+steatosis+independent+of+PPAR%CE%B1+activation+through+inhibition+of+SREBP-1+maturation+in+mice.&rft.au=Tanaka%2C+Naoki%3BZhang%2C+Xiuguo%3BSugiyama%2C+Eiko%3BKono%2C+Hiroyuki%3BHoriuchi%2C+Akira%3BNakajima%2C+Takero%3BKanbe%2C+Hiroki%3BTanaka%2C+Eiji%3BGonzalez%2C+Frank+J%3BAoyama%2C+Toshifumi&rft.aulast=Tanaka&rft.aufirst=Naoki&rft.date=2010-11-15&rft.volume=80&rft.issue=10&rft.spage=1601&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=1873-2968&rft_id=info:doi/10.1016%2Fj.bcp.2010.07.031 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-28 N1 - Date created - 2010-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bcp.2010.07.031 ER - TY - JOUR T1 - Ubiquitin-dependent and ubiquitin-independent control of subunit stoichiometry in the SWI/SNF complex. AN - 763174794; 20829358 AB - The mammalian SWI/SNF chromatin remodeling complex is a key player in multiple chromatin transactions. Core subunits of this complex, including the ATPase, Brg-1, and various Brg-1-associated factors (BAFs), work in concert to maintain a functional remodeling complex. This intra-complex regulation is supervised by protein-protein interactions, as stoichiometric levels of BAF proteins are maintained by proteasomal degradation. We show that the mechanism of BAF155-mediated stabilization of BAF57 involves blocking its ubiquitination by preventing interaction with TRIP12, an E3 ubiquitin ligase. Consequently, as opposed to complexed BAF57, whose principal lysines are unavailable for ubiquitination, uncomplexed BAF57 can be freely ubiquitinated and degraded by the proteasome. Additionally, a BAF57 mutant, which contains no lysine residues, was found to retain its ability to be stabilized by interaction with BAF155, suggesting that in addition to the ubiquitin-dependent mechanism of BAF57 degradation, there exists a ubiquitin-independent mechanism that may involve the direct interaction of BAF57 with the proteasome. We propose that this regulatory mechanism exists to ensure functional fidelity of the complex and prevent the accumulation of uncomplexed proteins, which may disrupt the normal activity of the complex. JF - The Journal of biological chemistry AU - Keppler, Brian R AU - Archer, Trevor K AD - Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2010/11/12/ PY - 2010 DA - 2010 Nov 12 SP - 35665 EP - 35674 VL - 285 IS - 46 KW - Carrier Proteins KW - 0 KW - Chromosomal Proteins, Non-Histone KW - DNA-Binding Proteins KW - Protein Subunits KW - SMARCC1 protein, human KW - SMARCE1 protein, human KW - SWI-SNF-B chromatin-remodeling complex KW - Transcription Factors KW - Ubiquitin KW - TRIP12 protein, human KW - EC 2.3.2.26 KW - Ubiquitin-Protein Ligases KW - EC 2.3.2.27 KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Index Medicus KW - Carrier Proteins -- metabolism KW - Carrier Proteins -- genetics KW - Humans KW - DNA-Binding Proteins -- genetics KW - Immunoprecipitation KW - Cell Line, Tumor KW - Protein Subunits -- metabolism KW - Protein Binding KW - Blotting, Western KW - Protein Subunits -- genetics KW - Transfection KW - Ubiquitin-Protein Ligases -- genetics KW - Ubiquitination KW - Ubiquitin-Protein Ligases -- metabolism KW - RNA Interference KW - Mutation KW - Amino Acid Substitution KW - DNA-Binding Proteins -- metabolism KW - Chromosomal Proteins, Non-Histone -- genetics KW - Ubiquitin -- metabolism KW - Proteasome Endopeptidase Complex -- metabolism KW - Transcription Factors -- metabolism KW - Chromosomal Proteins, Non-Histone -- metabolism KW - Transcription Factors -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/763174794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Ubiquitin-dependent+and+ubiquitin-independent+control+of+subunit+stoichiometry+in+the+SWI%2FSNF+complex.&rft.au=Keppler%2C+Brian+R%3BArcher%2C+Trevor+K&rft.aulast=Keppler&rft.aufirst=Brian&rft.date=2010-11-12&rft.volume=285&rft.issue=46&rft.spage=35665&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M110.173997 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-09 N1 - Date created - 2010-11-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO Rep. 2000 Dec;1(6):500-6 [11263494] Mol Cell. 2000 Dec;6(6):1287-95 [11163203] J Biol Chem. 2001 Apr 27;276(17):13852-7 [11278372] EMBO J. 2001 May 15;20(10):2367-75 [11350925] Oncogene. 2001 May 28;20(24):3067-75 [11420722] Curr Opin Genet Dev. 2002 Feb;12(1):73-9 [11790558] Mol Cell Biol. 2002 Mar;22(5):1307-16 [11839798] Nature. 2002 Mar 7;416(6876):99-103 [11882901] EMBO J. 2002 Aug 1;21(15):4094-103 [12145209] Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13125-30 [12232053] Nature. 2003 Jan 23;421(6921):448-53 [12540921] Curr Top Microbiol Immunol. 2003;274:143-69 [12596907] Rev Med Virol. 2003 Mar-Apr;13(2):99-110 [12627393] Mol Cell Biol. 2003 Sep;23(17):6210-20 [12917342] Oncogene. 2004 Apr 22;23(19):3462-73 [14990991] Genes Dev. 1996 Sep 1;10(17):2117-30 [8804307] EMBO J. 1996 Oct 1;15(19):5370-82 [8895581] Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4152-7 [9539705] Nature. 1998 Jul 9;394(6689):203-6 [9671307] Cancer Res. 1999 Jan 1;59(1):74-9 [9892189] Am J Hum Genet. 1999 Nov;65(5):1342-8 [10521299] Genes Dev. 2005 Feb 1;19(3):316-21 [15687255] Mol Cell Biol. 2005 Mar;25(6):2200-15 [15743818] Cell. 2005 Mar 25;120(6):803-15 [15797381] Mol Cell Biol. 2005 Oct;25(20):9016-27 [16199878] J Cell Physiol. 2006 May;207(2):309-14 [16155938] Mol Cell Endocrinol. 2007 Feb;265-266:162-7 [17240047] J Biol Chem. 2007 Apr 6;282(14):10614-24 [17255092] Genes Dev. 2007 Apr 15;21(8):942-55 [17437998] J Biol Chem. 2007 Nov 16;282(46):33649-58 [17878155] J Biol Chem. 2008 May 2;283(18):11924-34 [18303029] Cancer Res. 2008 Jun 15;68(12):4551-8 [18559499] Biochem Biophys Res Commun. 2008 Sep 19;374(2):294-8 [18627766] J Biol Chem. 2009 Apr 10;284(15):9796-803 [19218238] Nature. 2010 Jan 28;463(7280):474-84 [20110991] Hum Mol Genet. 1999 Dec;8(13):2359-68 [10556283] Oncogene. 1999 Dec 9;18(52):7559-65 [10602515] Mol Cell Biol. 2000 Mar;20(6):1899-910 [10688638] J Biol Chem. 2000 Jun 9;275(23):17771-7 [10748103] Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13796-800 [11095756] J Cell Physiol. 2001 Jan;186(1):136-45 [11147808] Mol Cell Biol. 2001 May;21(10):3598-603 [11313485] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M110.173997 ER - TY - JOUR T1 - Impact of vaccination and birth rate on the epidemiology of pertussis: a comparative study in 64 countries AN - 762271625; 13814503 AB - Bordetella pertussis infection remains an important public health problem worldwide despite decades of routine vaccination. A key indicator of the impact of vaccination programmes is the inter-epidemic period, which is expected to increase with vaccine uptake if there is significant herd immunity. Based on empirical data from 64 countries across the five continents over the past 30-70 years, we document the observed relationship between the average inter-epidemic period, birth rate and vaccine coverage. We then use a mathematical model to explore the range of scenarios for duration of immunity and transmission resulting from repeat infections that are consistent with empirical evidence. Estimates of pertussis periodicity ranged between 2 and 4.6 years, with a strong association with susceptible recruitment rate, defined as birth rate x (1 - vaccine coverage). Periodicity increased by 1.27 years on average after the introduction of national vaccination programmes (95% CI: 1.13, 1.41 years), indicative of increased herd immunity. Mathematical models suggest that the observed patterns of pertussis periodicity are equally consistent with loss of immunity that is not as rapid as currently thought, or with negligible transmission generated by repeat infections. We conclude that both vaccine coverage and birth rate drive pertussis periodicity globally and that vaccination induces strong herd immunity effects. A better understanding of the role of repeat infections in pertussis transmission is critical to refine existing control strategies. JF - Proceedings of the Royal Society of London, Series B: Biological Sciences AU - Broutin, H AU - Viboud, C AU - Grenfell, B T AU - Miller, MA AU - Rohani, P AD - Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, , Bethesda, MD, USA Y1 - 2010/11/07/ PY - 2010 DA - 2010 Nov 07 SP - 3239 EP - 3245 PB - Royal Society of London, 6 Carlton House Terrace London SW1Y 5AG UK VL - 277 IS - 1698 SN - 0962-8452, 0962-8452 KW - Ecology Abstracts; Immunology Abstracts KW - Pertussis KW - Mathematical models KW - Data processing KW - Recruitment KW - Immunity KW - Infection KW - Vaccination KW - Public health KW - Birth KW - Bordetella pertussis KW - Epidemiology KW - Periodicity KW - Vaccines KW - F 06905:Vaccines KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762271625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+Royal+Society+of+London%2C+Series+B%3A+Biological+Sciences&rft.atitle=Impact+of+vaccination+and+birth+rate+on+the+epidemiology+of+pertussis%3A+a+comparative+study+in+64+countries&rft.au=Broutin%2C+H%3BViboud%2C+C%3BGrenfell%2C+B+T%3BMiller%2C+MA%3BRohani%2C+P&rft.aulast=Broutin&rft.aufirst=H&rft.date=2010-11-07&rft.volume=277&rft.issue=1698&rft.spage=3239&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+Royal+Society+of+London%2C+Series+B%3A+Biological+Sciences&rft.issn=09628452&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Birth; Pertussis; Data processing; Mathematical models; Epidemiology; Recruitment; Periodicity; Vaccines; Immunity; Infection; Vaccination; Public health; Bordetella pertussis ER - TY - JOUR T1 - The Antioxidant Transcription Factor Nrf2 Negatively Regulates Autophagy and Growth Arrest Induced by the Anticancer Redox Agent Mitoquinone AN - 864952530; 13917956 AB - Mitoquinone (MitoQ) is a synthetically modified, redox-active ubiquinone compound that accumulates predominantly in mitochondria. We found that MitoQ is 30-fold more cytotoxic to breast cancer cells than to healthy mammary cells. MitoQ treatment led to irreversible inhibition of clonogenic growth of breast cancer cells through a combination of autophagy and apoptotic cell death mechanisms. Relatively limited cytotoxicity was seen with the parent ubiquinone coenzyme Q10. Inhibition of cancer cell growth by MitoQ was associated with G1/S cell cycle arrest and phosphorylation of the checkpoint kinases Chk1 and Chk2. The possible role of oxidative stress in MitoQ activity was investigated by measuring the products of hydroethidine oxidation. Increases in ethidium and dihydroethidium levels, markers of one-electron oxidation of hydroethidine, were observed at cytotoxic concentrations of MitoQ. Keap1, an oxidative stress sensor protein that regulates the antioxidant transcription factor Nrf2, underwent oxidation, degradation, and dissociation from Nrf2 in MitoQ-treated cells. Nrf2 protein levels, nuclear localization, and transcriptional activity also increased following MitoQ treatment. Knockdown of Nrf2 caused a 2-fold increase in autophagy and an increase in G1 cell cycle arrest in response to MitoQ but had no apparent effect on apoptosis. The Nrf2-regulated enzyme NQO1 is partly responsible for controlling the level of autophagy. Keap1 and Nrf2 act as redox sensors for oxidative perturbations that lead to autophagy. MitoQ and similar compounds should be further evaluated for novel anticancer activity. JF - Journal of Biological Chemistry AU - Rao, VAshutosh AU - Klein, Sarah R AU - Bonar, Spencer J AU - Zielonka, Jacek AU - Mizuno, Naoko AU - Dickey, Jennifer S AU - Keller, Paul W AU - Joseph, Joy AU - Kalyanaraman, Balaraman AU - Shacter, Emily AD - From the Laboratory of Biochemistry, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, the Free Radical Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, and the Laboratory of Structural Biology Research, National Institute for Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2010/11/05/ PY - 2010 DA - 2010 Nov 05 SP - 34447 EP - 34459 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 285 IS - 45 SN - 0021-9258, 0021-9258 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - CHK2 protein KW - Antioxidants KW - Apoptosis KW - Cell cycle KW - Enzymes KW - Mitochondria KW - NRF2 protein KW - Coenzyme Q10 KW - Cytotoxicity KW - Phosphorylation KW - ubiquinone KW - Oxidative stress KW - Transcription factors KW - Breast cancer KW - NAD(P)H dehydrogenase (quinone) KW - CHK1 protein KW - Phagocytosis KW - Antitumor activity KW - N 14835:Protein-Nucleic Acids Association KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864952530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=The+Antioxidant+Transcription+Factor+Nrf2+Negatively+Regulates+Autophagy+and+Growth+Arrest+Induced+by+the+Anticancer+Redox+Agent+Mitoquinone&rft.au=Rao%2C+VAshutosh%3BKlein%2C+Sarah+R%3BBonar%2C+Spencer+J%3BZielonka%2C+Jacek%3BMizuno%2C+Naoko%3BDickey%2C+Jennifer+S%3BKeller%2C+Paul+W%3BJoseph%2C+Joy%3BKalyanaraman%2C+Balaraman%3BShacter%2C+Emily&rft.aulast=Rao&rft.aufirst=VAshutosh&rft.date=2010-11-05&rft.volume=285&rft.issue=45&rft.spage=34447&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - CHK2 protein; Apoptosis; Antioxidants; Cell cycle; NRF2 protein; Mitochondria; Enzymes; Coenzyme Q10; Cytotoxicity; Phosphorylation; Oxidative stress; ubiquinone; Transcription factors; Breast cancer; CHK1 protein; NAD(P)H dehydrogenase (quinone); Phagocytosis; Antitumor activity ER - TY - JOUR T1 - Th1-driven immune reconstitution disease in Mycobacterium avium-infected mice AN - 839675965; 13966620 AB - Following antiretroviral therapy, a significant proportion of HIV+ patients with mycobacterial coinfections develop a paradoxical, poorly understood inflammatory disease termed immune reconstitution inflammatory syndrome (IRIS). Here, we show that Mycobacterium avium-infected T cell-deficient mice injected with CD4 T cells also develop an immune reconstitution disease (IRD) manifesting as weight loss, impaired lung function, and rapid mortality. This form of IRD requires Ag recognition and interferong production by the donor CD4 T cells and correlates with marked alterations in blood and tissue CD11b+ myeloid cells. Interestingly, disease is associated with impaired, rather than augmented, T-cell expansion and function and is not strictly dependent on lymphopenia-induced T-cell proliferation. Instead, our findings suggest that mycobacterial-associated IRIS results from a heightened sensitivity of infected lymphopenic hosts to the detrimental effects of Ag-driven CD4 T-cell responses. JF - Blood AU - Barber, Daniel L AU - Mayer-Barber, Katrin D AU - Antonelli, Lis RV AU - Wilson, Mark S AU - White, Sandra AU - Caspar, Patricia AU - Hieny, Sara AU - Sereti, Irini AU - Sher, Alan AD - Immunobiology Section, Laboratory of Parasitic Diseases, Immunopathogenesis Section, Laboratory of Parasitic Diseases, and Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD Y1 - 2010/11/04/ PY - 2010 DA - 2010 Nov 04 SP - 3485 EP - 3493 PB - The American Society of Hematology VL - 116 IS - 18 SN - 1528-0020, 1528-0020 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Mortality KW - Mycobacterium KW - antiretroviral therapy KW - Lymphopenia KW - Myeloid cells KW - Inflammation KW - Immune reconstitution KW - Blood KW - CD4 antigen KW - Inflammatory diseases KW - Human immunodeficiency virus KW - CD11b antigen KW - Lymphocytes T KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839675965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Th1-driven+immune+reconstitution+disease+in+Mycobacterium+avium-infected+mice&rft.au=Barber%2C+Daniel+L%3BMayer-Barber%2C+Katrin+D%3BAntonelli%2C+Lis+RV%3BWilson%2C+Mark+S%3BWhite%2C+Sandra%3BCaspar%2C+Patricia%3BHieny%2C+Sara%3BSereti%2C+Irini%3BSher%2C+Alan&rft.aulast=Barber&rft.aufirst=Daniel&rft.date=2010-11-04&rft.volume=116&rft.issue=18&rft.spage=3485&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=15280020&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Immune reconstitution; Mortality; Blood; CD4 antigen; Inflammatory diseases; CD11b antigen; antiretroviral therapy; Lymphopenia; Lymphocytes T; Myeloid cells; Inflammation; Mycobacterium; Human immunodeficiency virus ER - TY - JOUR T1 - Epidemiological Study of Anti-HPV16/18 Seropositivity and Subsequent Risk of HPV16 and -18 Infections AN - 954591167; 13967567 AB - BACKGROUND: Infection with human papillomavirus (HPV) 16 or HPV18 elicits an antibody response, but whether the elicited antibodies protect women against subsequent infection by a homologous HPV type compared with seronegative women is unknown. METHODS: Study participants were women aged 18-25 years at enrollment in the control group of the ongoing National Cancer Institute-sponsored, community-based, randomized HPV16/18 Costa Rica Vaccine Trial. At enrollment, 2813 participants were negative for cervical HPV16 DNA and 2950 for HPV18 DNA. Women were interviewed regarding sociodemographic data and medical and health history. Medical and pelvic examinations were conducted for all consenting sexually experienced women. Serum samples taken at enrollment were tested for total HPV16/18 antibodies with a polyclonal enzyme-linked immunosorbent assay, and cervical specimens were tested for type-specific HPV DNA over 4 years of follow-up. Using Poisson regression, we compared rate ratios of newly detected cervical HPV16 or HPV18 infection among homologous HPV-seropositive and HPV-seronegative women, adjusting for age, education, marital status, lifetime number of sexual partners, and smoking. RESULTS: There were 231 newly detected HPV16 infections during 5886 person-years among HPV16-seronegative women compared with 12 newly detected HPV16 infections during 581 person-years among HPV16-seropositive women with the highest HPV16 sero-levels. There were 136 newly detected HPV18 infections during 6352 person-years among HPV18-seronegative women compared with six new infections detected during 675 person-years among HPV18 seropositives with the highest sero-levels. After controlling for risk factors associated with newly detected HPV infection, having high HPV16 antibody titer at enrollment was associated with a reduced risk of subsequent HPV16 infection (women in the highest tertile of HPV16 antibody titers, adjusted rate ratio = 0.50, 95% confidence interval = 0.26 to 0.86 vs HPV16-seronegative women). Similarly, having high HPV18 antibody titer at enrollment was associated with a reduced risk of subsequent HPV18 infection (women in the highest tertile of HPV18 antibody titers, adjusted rate ratio = 0.36, 95% confidence interval = 0.14 to 0.76 vs HPV18-seronegative women). CONCLUSION: In this study population, having high antibody levels against HPV16 and HPV18 following natural infection was associated with reduced risk of subsequent HPV16 and HPV18 infections. JF - Journal of the National Cancer Institute AU - Safaeian, Mahboobeh AU - Porras, Carolina AU - Schiffman, Mark AU - Rodriguez, Ana Cecilia AU - Wacholder, Sholom AU - Gonzalez, Paula AU - Quint, Wim AU - van Doorn, Leen-Jan AU - Sherman, Mark E AU - Xhenseval, Valerie AU - Herrero, Rolando AU - Hildesheim, Allan AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD (MSa, MSc, SW, MES, AH) Y1 - 2010/11/03/ PY - 2010 DA - 2010 Nov 03 SP - 1653 EP - 1662 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 21 SN - 0027-8874, 0027-8874 KW - Virology & AIDS Abstracts; Risk Abstracts KW - Age KW - Antibodies KW - Antibody response KW - Cancer KW - Cervix KW - DNA KW - Data processing KW - Education KW - Enzyme-linked immunosorbent assay KW - Infection KW - Pelvis KW - Population studies KW - Risk factors KW - Sexual partners KW - Smoking KW - Vaccines KW - clinical trials KW - community involvement KW - infection KW - marriage KW - risk reduction KW - sexual behavior KW - Costa Rica KW - Human papillomavirus 18 KW - Human papillomavirus 16 KW - R2 23060:Medical and environmental health KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954591167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Epidemiological+Study+of+Anti-HPV16%2F18+Seropositivity+and+Subsequent+Risk+of+HPV16+and+-18+Infections&rft.au=Safaeian%2C+Mahboobeh%3BPorras%2C+Carolina%3BSchiffman%2C+Mark%3BRodriguez%2C+Ana+Cecilia%3BWacholder%2C+Sholom%3BGonzalez%2C+Paula%3BQuint%2C+Wim%3Bvan+Doorn%2C+Leen-Jan%3BSherman%2C+Mark+E%3BXhenseval%2C+Valerie%3BHerrero%2C+Rolando%3BHildesheim%2C+Allan&rft.aulast=Safaeian&rft.aufirst=Mahboobeh&rft.date=2010-11-03&rft.volume=102&rft.issue=21&rft.spage=1653&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-05-18 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Age; Data processing; Population studies; Antibody response; Infection; Sexual partners; Pelvis; Smoking; Antibodies; Risk factors; DNA; Vaccines; Cervix; sexual behavior; risk reduction; Education; infection; marriage; clinical trials; community involvement; Cancer; Human papillomavirus 16; Human papillomavirus 18; Costa Rica ER - TY - JOUR T1 - Apolipophorin-III Mediates Antiplasmodial Epithelial Responses in Anopheles gambiae (G3) Mosquitoes AN - 864950543; 14026131 AB - Apolipophorin-III (ApoLp-III) is known to play an important role in lipid transport and innate immunity in lepidopteran insects. However, there is no evidence of involvement of ApoLp-IIIs in the immune responses of dipteran insects such as Drosophila and mosquitoes. We report the molecular and functional characterization of An. gambiae apolipophorin-III (AgApoLp-III). Mosquito ApoLp-IIIs have diverged extensively from those of lepidopteran insects; however, the predicted tertiary structure of AgApoLp-III is similar to that of Manduca sexta (tobacco hornworm). We found that AgApoLp-III mRNA expression is strongly induced in the midgut of An. gambiae (G3 strain) mosquitoes in response to Plasmodium berghei infection. Furthermore, immunofluorescence stainings revealed that high levels of AgApoLp-III protein accumulate in the cytoplasm of Plasmodium-invaded cells and AgApoLp-III silencing increases the intensity of P. berghei infection by five fold. There are broad differences in the midgut epithelial responses to Plasmodium invasion between An. gambiae strains. In the G3 strain of An. gambiae AgApoLp-III participates in midgut epithelial defense responses that limit Plasmodium infection. JF - PLoS ONE AU - Gupta, Lalita AU - Noh, Ju Young AU - Jo, Yong Hun AU - Oh, Seung Han AU - Kumar, Sanjeev AU - Noh, Mi Young AU - Lee, Yong Seok AU - Cha, Sung-Jae AU - Seo, Sook Jae AU - Kim, Iksoo AU - Han, Yeon Soo AU - Barillas-Mury, Carolina AD - Mosquito Immunity and Vector Competence Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America Y1 - 2010/11/02/ PY - 2010 DA - 2010 Nov 02 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - 1 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; Entomology Abstracts KW - Lipids KW - Manduca sexta KW - Immunity KW - Immunofluorescence KW - Staining KW - Infection KW - Anopheles gambiae KW - Lepidoptera KW - Plasmodium berghei KW - Gene expression KW - Protein structure KW - Protein folding KW - Cytoplasm KW - Midgut KW - Immune response KW - Antiprotozoal agents KW - Tertiary structure KW - Drosophila KW - Aquatic insects KW - K 03340:Effects of Physical & Chemical Factors KW - Q1 08484:Species interactions: parasites and diseases KW - Z 05320:Physiology, Anatomy, and Biochemistry KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864950543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Apolipophorin-III+Mediates+Antiplasmodial+Epithelial+Responses+in+Anopheles+gambiae+%28G3%29+Mosquitoes&rft.au=Gupta%2C+Lalita%3BNoh%2C+Ju+Young%3BJo%2C+Yong+Hun%3BOh%2C+Seung+Han%3BKumar%2C+Sanjeev%3BNoh%2C+Mi+Young%3BLee%2C+Yong+Seok%3BCha%2C+Sung-Jae%3BSeo%2C+Sook+Jae%3BKim%2C+Iksoo%3BHan%2C+Yeon+Soo%3BBarillas-Mury%2C+Carolina&rft.aulast=Gupta&rft.aufirst=Lalita&rft.date=2010-11-02&rft.volume=5&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0015410 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Cytoplasm; Staining; Immunofluorescence; Immunity; Aquatic insects; Protein structure; Gene expression; Protein folding; Lipids; Antiprotozoal agents; Immune response; Midgut; Tertiary structure; Infection; Manduca sexta; Drosophila; Anopheles gambiae; Plasmodium berghei; Lepidoptera DO - http://dx.doi.org/10.1371/journal.pone.0015410 ER - TY - JOUR T1 - A Case-Control Study of Occupational Exposure to Trichloroethylene and Non-Hodgkin Lymphoma AN - 1677902780; 14444577 AB - Previous epidemiologic findings suggest an association between exposure to trichloroethylene (TCE), a chlorinated solvent primarily used for vapor degreasing of metal parts, and non-Hodgkin lymphoma (NHL). We investigated the association between occupational TCE exposure and NHL within a population-based case-control study using detailed exposure assessment methods. Cases (n = 1,189; 76% participation rate) and controls (n = 982; 52% participation rate) provided information on their occupational histories and, for selected occupations, on possible workplace exposure to TCE using job-specific interview modules. An industrial hygienist assessed potential TCE exposure based on this information and a review of the TCE industrial hygiene literature. We computed odds ratios (ORs) and 95% confidence intervals (CIs) relating NHL and different metrics of estimated TCE exposure, categorized using tertiles among exposed controls, with unexposed subjects as the reference group. We observed associations with NHL for the highest tertiles of estimated average weekly exposure (23 exposed cases; OR = 2.5; 95% CI, 1.1-6.1) and cumulative exposure (24 exposed cases; OR = 2.3; 95% CI, 1.0-5.0) to TCE. Tests for trend with these metrics surpassed or approached statistical significance (p-value for trend = 0.02 and 0.08, respectively); however, we did not observe dose-response relationships across the exposure levels. Overall, neither duration nor intensity of exposure was associated with NHL, although we observed an association with the lowest tertile of exposure duration (OR = 2.1; 95% CI, 1.0-4.7). Our findings offer additional support for an association between high levels of exposure to TCE and increased risk of NHL. However, we cannot rule out the possibility of confounding from other chlorinated solvents used for vapor degreasing and note that our exposure assessment methods have not been validated. JF - Environmental Health Perspectives AU - Purdue, Mark P AU - Bakke, Berit AU - Stewart, Patricia AU - De Roos, Anneclaire J AU - Schenk, Maryjean AU - Lynch, Charles F AU - Bernstein, Leslie AU - Morton, Lindsay M AU - Cerhan, James R AU - Severson, Richard K AU - Cozen, Wendy AU - Davis, Scott AU - Rothman, Nathaniel AU - Hartge, Patricia AU - Colt, Joanne S AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA Y1 - 2010/11/02/ PY - 2010 DA - 2010 Nov 02 SP - 232 EP - 238 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 119 IS - 2 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - cancer KW - non-Hodgkin lymphoma KW - occupational KW - solvents KW - trichloroethylene KW - Control equipment KW - Assessments KW - Occupational KW - Exposure KW - Solvents KW - Chlorination KW - Trichloroethylene KW - Trends KW - Vapor degreasing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677902780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Case-Control+Study+of+Occupational+Exposure+to+Trichloroethylene+and+Non-Hodgkin+Lymphoma&rft.au=Purdue%2C+Mark+P%3BBakke%2C+Berit%3BStewart%2C+Patricia%3BDe+Roos%2C+Anneclaire+J%3BSchenk%2C+Maryjean%3BLynch%2C+Charles+F%3BBernstein%2C+Leslie%3BMorton%2C+Lindsay+M%3BCerhan%2C+James+R%3BSeverson%2C+Richard+K%3BCozen%2C+Wendy%3BDavis%2C+Scott%3BRothman%2C+Nathaniel%3BHartge%2C+Patricia%3BColt%2C+Joanne+S&rft.aulast=Purdue&rft.aufirst=Mark&rft.date=2010-11-02&rft.volume=119&rft.issue=2&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1289/ehp.1002106 ER - TY - JOUR T1 - Body mass index, agricultural pesticide use, and cancer incidence in the Agricultural Health Study cohort AN - 954611721; 14236760 AB - Obesity is associated with increased risks of several cancers including colon and female breast. Pesticide use in agricultural populations has also been linked with higher risks of various cancers. However, the interaction between obesity and pesticide use on cancer risk has not been well studied. Using data from the Agricultural Health Study, we examined the association between body mass index (BMI) and the risk of cancer at 17 sites and the interaction between BMI and pesticide use. Pesticide applicators residing in Iowa and North Carolina and their spouses were enrolled between 1993 and 1997 and given a self-administered questionnaire to obtain pesticide use and other information. This analysis included 39,628 men and 28,319 women with height and weight data who were cancer-free at enrollment. Among these participants, 4,432 were diagnosed with cancer between enrollment and 2005 and 64% were overweight or obese. BMI (per 1kg/m super(2)) was positively associated with colon cancer in men (hazard ratio (HR) 1.05, 95% confidence interval (CI) 1.02-1.09) and breast cancer in postmenopausal women (HR 1.03, 95% CI 1.01-1.06). In contrast, BMI was inversely associated with lung cancer in men, with a significant association in ever smokers (HR 0.92, 95% CI 0.88-0.97) and a null association in never smokers. The positive association between BMI and colon cancer in men was significant in those who ever used carbofuran (HR=1.10, 95% CI 1.04-1.17; p-interaction=0.04) or metolachlor (HR=1.09, 95% CI 1.04-1.15; p-interaction=0.02) but was null in non-users of these pesticides. Among male ever smokers, the inverse association between BMI and lung cancer was significant in non-users of carbofuran (HR=0.87, 95% CI=0.82-0.92) but was null in users of carbofuran (p-interaction=0.02). These findings suggest that certain pesticides may modify the effects of BMI on the risks of colon and lung cancers. JF - Cancer Causes & Control AU - Andreotti, Gabriella AU - Hou, Lifang AU - Beane Freeman, Laura E AU - Mahajan, Rajeev AU - Koutros, Stella AU - Coble, Joseph AU - Lubin, Jay AU - Blair, Aaron AU - Hoppin, Jane A AU - Alavanja, Michael AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, 6120 Executive Blvd., EPS 8011, MSC 7240, Bethesda, MD, 20892, USA, andreotg@mail.nih.gov Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1759 EP - 1775 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 21 IS - 11 SN - 0957-5243, 0957-5243 KW - Physical Education Index; Risk Abstracts; Health & Safety Science Abstracts KW - USA, North Carolina KW - Body mass KW - Women KW - obesity KW - Breasts KW - Health KW - body mass KW - Lung cancer KW - Obesity KW - post-menopause KW - Men KW - Height KW - carbofuran KW - Cancer KW - USA, Iowa KW - Pesticides KW - Breast cancer KW - Lungs KW - H 5000:Pesticides KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954611721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Body+mass+index%2C+agricultural+pesticide+use%2C+and+cancer+incidence+in+the+Agricultural+Health+Study+cohort&rft.au=Andreotti%2C+Gabriella%3BHou%2C+Lifang%3BBeane+Freeman%2C+Laura+E%3BMahajan%2C+Rajeev%3BKoutros%2C+Stella%3BCoble%2C+Joseph%3BLubin%2C+Jay%3BBlair%2C+Aaron%3BHoppin%2C+Jane+A%3BAlavanja%2C+Michael&rft.aulast=Andreotti&rft.aufirst=Gabriella&rft.date=2010-11-01&rft.volume=21&rft.issue=11&rft.spage=1759&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-010-9603-9 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-05-07 N1 - SubjectsTermNotLitGenreText - Obesity; Men; Body mass; Women; Height; Lungs; Health; Breasts; Cancer; post-menopause; body mass; Pesticides; obesity; Breast cancer; carbofuran; Lung cancer; USA, North Carolina; USA, Iowa DO - http://dx.doi.org/10.1007/s10552-010-9603-9 ER - TY - JOUR T1 - A new approach to estimating the signal dimension of concatenated resting-state functional MRI data sets AN - 954594754; 13954762 AB - Estimating the effective signal dimension of resting-state functional MRI (fMRI) data sets (i.e., selecting an appropriate number of signal components) is essential for data-driven analysis. However, current methods are prone to overestimate the dimensions, especially for concatenated group data sets. This work aims to develop improved dimension estimation methods for group fMRI data generated by data reduction and grouping procedure at multiple levels. We proposed a "noise-blurring" approach to suppress intragroup signal variations and to correct spectral alterations caused by the data reduction, which should be responsible for the group dimension overestimation. This technique was evaluated on both simulated group data sets and in vivo resting-state fMRI data sets acquired from 14 normal human subjects during five different scan sessions. Reduction and grouping procedures were repeated at three levels in either "scan-session-subject" or "scan-subject-session" order. Compared with traditional estimation methods, our approach exhibits a stronger immunity against intragroup signal variation, less sensitivity to group size and a better agreement on the dimensions at the third level between the two grouping orders. JF - Magnetic Resonance Imaging AU - Chen, Sharon AU - Ross, Thomas J AU - Chuang, Keh-Shih AU - Stein, Elliot A AU - Yang, Yihong AU - Zhan, Wang AD - Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA, wang.zhan@ucsf.edu Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1344 EP - 1352 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 28 IS - 9 SN - 0730-725X, 0730-725X KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954594754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=A+new+approach+to+estimating+the+signal+dimension+of+concatenated+resting-state+functional+MRI+data+sets&rft.au=Chen%2C+Sharon%3BRoss%2C+Thomas+J%3BChuang%2C+Keh-Shih%3BStein%2C+Elliot+A%3BYang%2C+Yihong%3BZhan%2C+Wang&rft.aulast=Chen&rft.aufirst=Sharon&rft.date=2010-11-01&rft.volume=28&rft.issue=9&rft.spage=1344&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2010.04.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Data processing DO - http://dx.doi.org/10.1016/j.mri.2010.04.002 ER - TY - JOUR T1 - Evaluation of Cisplatin in Combination with b-Elemene as a Regimen for Prostate Cancer Chemotherapy AN - 954580934; 13888169 AB - Abstract: Cisplatin is one of the most potent chemotherapeutic agents for the treatment of many types of solid tumours. Nevertheless, it is not the first-line drug for prostate cancer chemotherapy, because prostate tumour cells exhibit intrinsic and acquired resistance to cisplatin. We have previously demonstrated that b-elemene, a novel plant-derived anti-neoplastic with low toxicity, inhibits lung and ovarian carcinoma cell growth in vitro. In the present study, we explored the therapeutically chemosensitizing effect of b-elemene on cisplatin anti-tumour efficacy in androgen-independent prostate cancer cells as well as the underlying mechanism. b-Elemene significantly increased cisplatin cytotoxicity in the androgen-independent prostate carcinoma cell lines DU145 and PC-3. In addition, b-elemene markedly promoted cisplatin-induced apoptotic cell death in both cell lines, as determined by three different apoptosis assays. b-Elemene augmented the cisplatin-induced activation of caspase-3-7-10 and caspase-9, cleavage of caspase-3 and -9, suppression of Bcl-2 and Bcl-XL expression, and release of cytochrome c from mitochondria in these cells. Thus, b-elemene enhancement of cisplatin-induced apoptosis via mitochondrial activation of the caspase-mediated apoptotic pathway may account for the augmented anti-cancer potency of cisplatin in prostate cancer. Cisplatin combined with b-elemene as a chemosensitizer or adjuvant warrants further study and may be potentially useful as a first-line treatment of androgen-independent prostate carcinomas. JF - Basic & Clinical Pharmacology & Toxicology AU - Li, Qingdi Quentin AU - Wang, Gangduo AU - Reed, Eddie AU - Huang, Lan AU - Cuff, Christopher F AD - 1Department of Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia University Health Sciences Center, Morgantown, WV, USA, liquenti@niaid.nih.gov Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 868 EP - 876 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 107 IS - 5 SN - 1742-7835, 1742-7835 KW - Toxicology Abstracts KW - Adjuvants KW - Apoptosis KW - Bcl-2 protein KW - Bcl-x protein KW - Caspase-3 KW - Caspase-9 KW - Chemotherapy KW - Cisplatin KW - Cytochrome c KW - Cytotoxicity KW - Lung carcinoma KW - Mitochondria KW - Ovarian carcinoma KW - Plants KW - Prostate cancer KW - Toxicity KW - Tumor cell lines KW - Tumors KW - prostate carcinoma KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954580934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+%26+Clinical+Pharmacology+%26+Toxicology&rft.atitle=Evaluation+of+Cisplatin+in+Combination+with+b-Elemene+as+a+Regimen+for+Prostate+Cancer+Chemotherapy&rft.au=Li%2C+Qingdi+Quentin%3BWang%2C+Gangduo%3BReed%2C+Eddie%3BHuang%2C+Lan%3BCuff%2C+Christopher+F&rft.aulast=Li&rft.aufirst=Qingdi&rft.date=2010-11-01&rft.volume=107&rft.issue=5&rft.spage=868&rft.isbn=&rft.btitle=&rft.title=Basic+%26+Clinical+Pharmacology+%26+Toxicology&rft.issn=17427835&rft_id=info:doi/10.1111%2Fj.1742-7843.2010.00592.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Number of references - 57 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Caspase-9; Apoptosis; Lung carcinoma; Chemotherapy; Mitochondria; Tumors; Toxicity; Adjuvants; prostate carcinoma; Bcl-x protein; Cytotoxicity; Tumor cell lines; Cytochrome c; Prostate cancer; Cisplatin; Caspase-3; Plants; Ovarian carcinoma; Bcl-2 protein DO - http://dx.doi.org/10.1111/j.1742-7843.2010.00592.x ER - TY - JOUR T1 - In utero exposure to tobacco smoke and subsequent reduced fertility in females AN - 954575444; 13843349 AB - BACKGROUND: Animal studies have shown that in utero exposure to chemicals in tobacco smoke reduces female fertility, but epidemiological findings have been inconsistent. METHODS: We examined the association between in utero exposure to tobacco smoke and female fertility among women in the Norwegian Mother and Child Cohort Study, enrolled from 1999 to 2007. Around the 17th week of pregnancy, participants reported how long they took to conceive (time to pregnancy), and whether their mother smoked while pregnant with the participant. This analysis included 48 319 planned pregnancies among women aged 15-44 years. We estimated fecundability odds ratios (FORs) using a discrete-time survival analysis, adjusting for age, education and adult tobacco smoking. RESULTS: The adjusted FOR for in utero exposure to tobacco smoke among all subjects was 0.96 [95% confidence interval (CI): 0.93, 0.98], among subjects reporting no adult tobacco smoking or passive exposure it was 0.96 (95% CI: 0.93, 0.99) and among subjects reporting adult tobacco smoking or passive exposure it was 0.95 (95% CI: 0.91, 0.99). We performed a probabilistic sensitivity analysis to estimate the effect of exposure and outcome misclassification on the results, and, as expected, the association became more pronounced after taking misclassification into account. CONCLUSIONS: This large cohort study supports a small-to-modest association between in utero exposure to tobacco smoke and reduced fertility. JF - Human Reproduction AU - Ye, Xibiao AU - Skjaerven, Rolv AU - Basso, Olga AU - Baird, Donna D AU - Eggesbo, Merete AU - Uicab, Lea Aurora Cupul AU - Haug, Kjell AU - Longnecker, Matthew P AD - Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Human and Health Services, Research Triangle Park, NC 27709, USA Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 2901 EP - 2906 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 25 IS - 11 SN - 0268-1161, 0268-1161 KW - Toxicology Abstracts KW - Smoke KW - Tobacco smoking KW - Fertility KW - Age KW - Survival KW - Intrauterine exposure KW - Pregnancy KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954575444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Reproduction&rft.atitle=In+utero+exposure+to+tobacco+smoke+and+subsequent+reduced+fertility+in+females&rft.au=Ye%2C+Xibiao%3BSkjaerven%2C+Rolv%3BBasso%2C+Olga%3BBaird%2C+Donna+D%3BEggesbo%2C+Merete%3BUicab%2C+Lea+Aurora+Cupul%3BHaug%2C+Kjell%3BLongnecker%2C+Matthew+P&rft.aulast=Ye&rft.aufirst=Xibiao&rft.date=2010-11-01&rft.volume=25&rft.issue=11&rft.spage=2901&rft.isbn=&rft.btitle=&rft.title=Human+Reproduction&rft.issn=02681161&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Smoke; Tobacco smoking; Age; Fertility; Survival; Intrauterine exposure; Pregnancy ER - TY - JOUR T1 - Non-parametric tests for right-censored data with biased sampling AN - 940979339; 4280527 AB - Testing the equality of two survival distributions can be difficult in a prevalent cohort study when non-random sampling of subjects is involved. Owing to the biased sampling scheme, the independent censoring assumption is often violated. Although the issues about biased inference caused by length-biased sampling have been widely recognized in the statistical, epidemiological and economical literature, there is no satisfactory solution for efficient two-sample testing. We propose an asymptotic most efficient non-parametric test by properly adjusting for length-biased sampling. The test statistic is derived from a full likelihood function and can be generalized from the two-sample test to a k-sample test. The asymptotic properties of the test statistic under the null hypothesis are derived by using its asymptotic independent and identically distributed representation. We conduct extensive Monte Carlo simulations to evaluate the performance of the test statistics proposed and compare them with the conditional test and the standard log-rank test for various biased sampling schemes and right-censoring mechanisms. For length-biased data, empirical studies demonstrated that the test proposed is substantially more powerful than the existing methods. For general left-truncated data, the test proposed is robust, still maintains accurate control of the type I error rate and is also more powerful than the existing methods, if the truncation patterns and right censoring patterns are the same between the groups. We illustrate the methods by using two real data examples. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Ning, Jing AU - Qin, Jing AU - Shen, Yu AD - University of Texas ; National Institute of Allergy and Infectious Diseases Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 609 EP - 630 VL - 72 IS - 5 SN - 1369-7412, 1369-7412 KW - Economics KW - Monte Carlo simulation KW - Cohort analysis KW - Computational methods KW - Sampling KW - Data analysis KW - Statistical methods KW - Bias UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/940979339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Non-parametric+tests+for+right-censored+data+with+biased+sampling&rft.au=Ning%2C+Jing%3BQin%2C+Jing%3BShen%2C+Yu&rft.aulast=Ning&rft.aufirst=Jing&rft.date=2010-11-01&rft.volume=72&rft.issue=5&rft.spage=609&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=13697412&rft_id=info:doi/10.1111%2Fj.1467-9868.2010.00742.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11255 12228 10919; 1565 1362 2688 2449 10404; 8268 12265 3865 4025 10214 12224 971 12228 10919; 12228 10919; 3279 971 3286; 2671 10919; 2457 2459 5676 3279 971 3286 DO - http://dx.doi.org/10.1111/j.1467-9868.2010.00742.x ER - TY - JOUR T1 - Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice AN - 923201549; 15536898 AB - Immunotherapies based on adoptive cell transfer are highly effective in the treatment of metastatic melanoma, but the use of this approach in other cancer histologies has been hampered by the identification of appropriate target molecules. Immunologic approaches targeting tumor vasculature provide a means for the therapy of multiple solid tumor types. We developed a method to target tumor vasculature, using genetically redirected syngeneic or autologous T cells. Mouse and human T cells were engineered to express a chimeric antigen receptor (CAR) targeted against VEGFR-2, which is overexpressed in tumor vasculature and is responsible for VEGF-mediated tumor progression and metastasis. Mouse and human T cells expressing the relevant VEGFR-2 CARs mediated specific immune responses against VEGFR-2 protein as well as VEGFR-2-expressing cells in vitro. A single dose of VEGFR-2 CAR-engineered mouse T cells plus exogenous IL-2 significantly inhibited the growth of 5 different types of established, vascularized syngeneic tumors in 2 different strains of mice and prolonged the survival of mice. T cells transduced with VEGFR-2 CAR showed durable and increased tumor infiltration, correlating with their antitumor effect. This approach provides a potential method for the gene therapy of a variety of human cancers. JF - Journal of Clinical Investigation AU - Chinnasamy, D AU - Yu, Z AU - Theoret, M R AU - Zhao, Y AU - Shrimali, R K AU - Morgan, R A AU - Feldman, SA AU - Restifo, N P AU - Rosenberg, SA AD - Surgery Branch, National Cancer Institute (NCI), Clinical Research Center, Bethesda, Maryland, USA Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 3953 EP - 3968 VL - 120 IS - 11 SN - 0021-9738, 0021-9738 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Antitumor activity KW - Tumors KW - W 30905:Medical Applications KW - G 07730:Development & Cell Cycle KW - F 06950:Immunogenetics, MHC, HLA KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/923201549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Investigation&rft.atitle=Gene+therapy+using+genetically+modified+lymphocytes+targeting+VEGFR-2+inhibits+the+growth+of+vascularized+syngenic+tumors+in+mice&rft.au=Chinnasamy%2C+D%3BYu%2C+Z%3BTheoret%2C+M+R%3BZhao%2C+Y%3BShrimali%2C+R+K%3BMorgan%2C+R+A%3BFeldman%2C+SA%3BRestifo%2C+N+P%3BRosenberg%2C+SA&rft.aulast=Chinnasamy&rft.aufirst=D&rft.date=2010-11-01&rft.volume=120&rft.issue=11&rft.spage=3953&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Investigation&rft.issn=00219738&rft_id=info:doi/10.1172%2FJCI43490 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2014-03-20 N1 - SubjectsTermNotLitGenreText - Tumors DO - http://dx.doi.org/10.1172/JCI43490 ER - TY - JOUR T1 - Education resources of the National Center for Biotechnology Information AN - 915487776; 16120271 AB - The National Center for Biotechnology Information (NCBI) hosts 39 literature and molecular biology databases containing almost half a billion records. As the complexity of these data and associated resources and tools continues to expand, so does the need for educational resources to help investigators, clinicians, information specialists and the general public make use of the wealth of public data available at the NCBI. This review describes the educational resources available at NCBI via the NCBI Education page (www.ncbi.nlm.nih.gov/Education/). These resources include materials designed for new users, such as About NCBI and the NCBI Guide, as well as documentation, Frequently Asked Questions (FAQs) and writings on the NCBI Bookshelf such as the NCBI Help Manual and the NCBI Handbook. NCBI also provides teaching materials such as tutorials, problem sets and educational tools such as the Amino Acid Explorer, PSSM Viewer and Ebot. NCBI also offers training programs including the Discovery Workshops, webinars and tutorials at conferences. To help users keep up-to-date, NCBI produces the online NCBI News and offers RSS feeds and mailing lists, along with a presence on Facebook, Twitter and YouTube. JF - Briefings in Bioinformatics AU - Cooper, Peter S AU - Lipshultz, Dawn AU - Matten, Wayne T AU - McGinnis, Scott D AU - Pechous, Steven AU - Romiti, Monica L AU - Tao, Tao AU - Valjavec-Gratian, Majda AU - Sayers, Eric W Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 563 EP - 569 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 11 IS - 6 SN - 1467-5463, 1467-5463 KW - Biotechnology and Bioengineering Abstracts KW - Bioinformatics KW - education KW - tutorials KW - NCBI KW - databases KW - GenBank KW - Databases KW - Data processing KW - Amino acids KW - Conferences KW - Internet KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/915487776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Briefings+in+Bioinformatics&rft.atitle=Education+resources+of+the+National+Center+for+Biotechnology+Information&rft.au=Cooper%2C+Peter+S%3BLipshultz%2C+Dawn%3BMatten%2C+Wayne+T%3BMcGinnis%2C+Scott+D%3BPechous%2C+Steven%3BRomiti%2C+Monica+L%3BTao%2C+Tao%3BValjavec-Gratian%2C+Majda%3BSayers%2C+Eric+W&rft.aulast=Cooper&rft.aufirst=Peter&rft.date=2010-11-01&rft.volume=11&rft.issue=6&rft.spage=563&rft.isbn=&rft.btitle=&rft.title=Briefings+in+Bioinformatics&rft.issn=14675463&rft_id=info:doi/10.1093%2Fbib%2Fbbq022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Databases; Amino acids; Data processing; Conferences; Bioinformatics; Internet DO - http://dx.doi.org/10.1093/bib/bbq022 ER - TY - JOUR T1 - PS3-57 Cytokine studies in relation to anti-TB antibodies in brain tuberculosis AN - 883049363; 15319648 JF - Cytokine AU - Patil, Shripad A AU - Kulkarni, G B AD - Department of Neuro-Microbiology and Neurology, National Institute of Mental health and Neurosciences, Bangalore, India Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 93 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 52 IS - 1-2 SN - 1043-4666, 1043-4666 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Antibodies KW - Mycobacterium KW - Brain KW - Cytokines KW - Tuberculosis KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883049363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytokine&rft.atitle=PS3-57+Cytokine+studies+in+relation+to+anti-TB+antibodies+in+brain+tuberculosis&rft.au=Patil%2C+Shripad+A%3BKulkarni%2C+G+B&rft.aulast=Patil&rft.aufirst=Shripad&rft.date=2010-11-01&rft.volume=52&rft.issue=1-2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Cytokine&rft.issn=10434666&rft_id=info:doi/10.1016%2Fj.cyto.2010.07.396 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Antibodies; Brain; Cytokines; Tuberculosis; Mycobacterium DO - http://dx.doi.org/10.1016/j.cyto.2010.07.396 ER - TY - JOUR T1 - SS11-1 Therapeutic exploitation of shared IFN gamma and IFN alpha signaling for mycobacterial disease AN - 883019372; 15319589 JF - Cytokine AU - Bax, H AU - Freeman, A F AU - Hsu, A P AU - Browne, S K AU - Marciano, B E AU - Paulson, M AU - Fowler, C AU - Ding, L AU - Sampaio, E P AU - Holland, S M AD - Laboratory of Clinical Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 80 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 52 IS - 1-2 SN - 1043-4666, 1043-4666 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Mycobacterium KW - alpha -Interferon KW - Cytokines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883019372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytokine&rft.atitle=SS11-1+Therapeutic+exploitation+of+shared+IFN+gamma+and+IFN+alpha+signaling+for+mycobacterial+disease&rft.au=Bax%2C+H%3BFreeman%2C+A+F%3BHsu%2C+A+P%3BBrowne%2C+S+K%3BMarciano%2C+B+E%3BPaulson%2C+M%3BFowler%2C+C%3BDing%2C+L%3BSampaio%2C+E+P%3BHolland%2C+S+M&rft.aulast=Bax&rft.aufirst=H&rft.date=2010-11-01&rft.volume=52&rft.issue=1-2&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Cytokine&rft.issn=10434666&rft_id=info:doi/10.1016%2Fj.cyto.2010.07.332 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - alpha -Interferon; Cytokines; Mycobacterium DO - http://dx.doi.org/10.1016/j.cyto.2010.07.332 ER - TY - JOUR T1 - Mesocorticolimbic circuits are impaired in chronic cocaine users as demonstrated by resting-state functional connectivity AN - 876234287; 15124162 AB - Preclinical models have consistently demonstrated the importance of the mesocorticolimbic (MCL) brain reward system in drug dependence, with critical molecular and cellular neuroadaptations identified within these structures following chronic cocaine administration. Cocaine dependent individuals manifest alterations in reward functioning that may relate to changes induced by cocaine or to pre-existing differences related to vulnerability to addiction. The circuit level manifestations of these drug-induced plastic changes and predispositions to drug dependence are poorly understood in preclinical models and virtually unknown in human drug dependence. Using whole-brain resting-state fMRI connectivity analysis with 'seed voxels' placed within individual nodes of the MCL system, we report network-specific functional connectivity strength decreases in cocaine users within distinct circuits of the system, including between ventral tegmental area (VTA) and a region encompassing thalamus/lentiform nucleus/nucleus accumbens, between amygdala and medial prefrontal cortex (mPFC), and between hippocampus and dorsal mPFC. Further, regression analysis on regions showing significant functional connectivity decrease in chronic cocaine users revealed that the circuit strength between VTA and thalamus/lentiform nucleus/nucleus accumbens was negatively correlated with years of cocaine use. This is the first evidence of circuit-related changes in human cocaine dependence and is consistent with the range of cognitive and behavioral disruptions seen in cocaine dependence. As potential circuit level biomarkers of cocaine dependence, these circuit alterations may be usefully applied in treatment development and monitoring treatment outcome. JF - NeuroImage AU - Gu, Hong AU - Salmeron, Betty Jo AU - Ross, Thomas J AU - Geng, Xiujuan AU - Zhan, Wang AU - Stein, Elliot A AU - Yang, Yihong AD - Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA Y1 - 2010/11/01/ PY - 2010 DA - 2010 Nov 01 SP - 593 EP - 601 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 53 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Addiction KW - Cocaine KW - W 30910:Imaging KW - N3:11001 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876234287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Mesocorticolimbic+circuits+are+impaired+in+chronic+cocaine+users+as+demonstrated+by+resting-state+functional+connectivity&rft.au=Gu%2C+Hong%3BSalmeron%2C+Betty+Jo%3BRoss%2C+Thomas+J%3BGeng%2C+Xiujuan%3BZhan%2C+Wang%3BStein%2C+Elliot+A%3BYang%2C+Yihong&rft.aulast=Gu&rft.aufirst=Hong&rft.date=2010-11-01&rft.volume=53&rft.issue=2&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.06.066 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Cocaine DO - http://dx.doi.org/10.1016/j.neuroimage.2010.06.066 ER - TY - JOUR T1 - Nanotechnology and HIV: potential applications for treatment and prevention AN - 869585179; 14821177 AB - HIV/AIDS is a global pandemic and is the leading infectious cause of death among adults. Although antiretroviral (ARV) therapy has dramatically improved the quality of life and increased the life expectancy of those infected with HIV, life-long suppressive treatment is required and a cure for HIV infection remains elusive; frequency of dosing and drug toxicity as well as the development of viral resistance pose additional limitations. Furthermore, preventative measures such as a vaccine or microbicide are urgently needed to curb the rate of new infections. The capabilities inherent to nanotechnology hold much potential for impact in the field of HIV treatment and prevention. This article reviews the potential for the multidisciplinary field of nanotechnology to advance the fields of HIV treatment and prevention. WIREs Nanomed Nanobiotechnol 2010 2 693-702 JF - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology AU - Kim, Peter S AU - Read, Sarah W AD - Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA, readsa@niaid.nih.gov Y1 - 2010/11/01/ PY - 2010 DA - 2010 Nov 01 SP - 693 EP - 702 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK VL - 2 IS - 6 SN - 1939-0041, 1939-0041 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Acquired immune deficiency syndrome KW - Life span KW - Drug development KW - Toxicity KW - Infection KW - pandemics KW - Antiviral agents KW - Human immunodeficiency virus KW - Vaccines KW - nanotechnology KW - Quality of life KW - microbicides KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869585179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.atitle=Nanotechnology+and+HIV%3A+potential+applications+for+treatment+and+prevention&rft.au=Kim%2C+Peter+S%3BRead%2C+Sarah+W&rft.aulast=Kim&rft.aufirst=Peter&rft.date=2010-11-01&rft.volume=2&rft.issue=6&rft.spage=693&rft.isbn=&rft.btitle=&rft.title=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.issn=19390041&rft_id=info:doi/10.1002%2Fwnan.118 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - pandemics; Acquired immune deficiency syndrome; Antiviral agents; Life span; Drug development; Vaccines; Toxicity; Infection; microbicides; Quality of life; nanotechnology; Human immunodeficiency virus DO - http://dx.doi.org/10.1002/wnan.118 ER - TY - JOUR T1 - Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists AN - 867737355; 14236770 AB - Objective: Ionizing radiation, an established breast cancer risk factor, has been shown to induce oxidative damage and chronic inflammation. Polymorphic variation in oxidative stress and inflammatory-mediated pathway genes may modify radiation-related breast cancer risk. Methods: We estimated breast cancer risk for 28 common variants in 16 candidate genes involved in these pathways among 859 breast cancer cases and 1,083 controls nested within the US Radiologic Technologists cohort. We estimated associations between occupational and personal diagnostic radiation exposures with breast cancer by modeling the odds ratio (OR) as a linear function in logistic regression models and assessed heterogeneity of the dose-response across genotypes. Results: There was suggestive evidence of an interaction between the rs5277 variant in PTGS2 and radiation-related breast cancer risk. The excess OR (EOR)/Gy from occupational radiation exposure=5.5 (95%CI 1.2-12.5) for the GG genotype versus EOR/Gy<0 (95%CI<0-3.8) and EOR/Gy<0 (95%CI<0-14.8) for the GC and CC genotypes, respectively, (p sub(interaction)=0.04). The association between radiation and breast cancer was not modified by other SNPs examined. Conclusions: This study suggests that variation in PTGS2 may modify the breast cancer risk from occupational radiation exposure, but replication in other populations is needed to confirm this result. JF - Cancer Causes & Control AU - Schonfeld, Sara J AU - Bhatti, Parveen AU - Brown, Elizabeth E AU - Linet, Martha S AU - Simon, Steven L AU - Weinstock, Robert M AU - Hutchinson, Amy A AU - Stovall, Marilyn AU - Preston, Dale L AU - Alexander, Bruce H AU - Doody, Michele M AU - Sigurdson, Alice J AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, 6120 Executive Blvd MSC 7238, Bethesda, MD, 20892, USA, schonfes@mail.nih.gov schonfes@mail.nih.gov schonfes@mail.nih.gov Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1857 EP - 1866 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 21 IS - 11 SN - 0957-5243, 0957-5243 KW - Genetics Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Breast cancer KW - Cancer KW - Dose-response effects KW - Gene polymorphism KW - Genotypes KW - Guanylate cyclase KW - Inflammation KW - Ionizing radiation KW - Models KW - Occupational exposure KW - Oxidative stress KW - Regression analysis KW - Replication KW - Risk factors KW - Single-nucleotide polymorphism KW - oxidative stress KW - USA KW - X 24390:Radioactive Materials KW - G 07710:Chemical Mutagenesis & Radiation KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867737355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Polymorphisms+in+oxidative+stress+and+inflammation+pathway+genes%2C+low-dose+ionizing+radiation%2C+and+the+risk+of+breast+cancer+among+US+radiologic+technologists&rft.au=Schonfeld%2C+Sara+J%3BBhatti%2C+Parveen%3BBrown%2C+Elizabeth+E%3BLinet%2C+Martha+S%3BSimon%2C+Steven+L%3BWeinstock%2C+Robert+M%3BHutchinson%2C+Amy+A%3BStovall%2C+Marilyn%3BPreston%2C+Dale+L%3BAlexander%2C+Bruce+H%3BDoody%2C+Michele+M%3BSigurdson%2C+Alice+J&rft.aulast=Schonfeld&rft.aufirst=Sara&rft.date=2010-11-01&rft.volume=21&rft.issue=11&rft.spage=1857&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-010-9613-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-09-10 N1 - SubjectsTermNotLitGenreText - Guanylate cyclase; Single-nucleotide polymorphism; Replication; Oxidative stress; Risk factors; Gene polymorphism; Ionizing radiation; Regression analysis; Breast cancer; Occupational exposure; Models; Inflammation; Dose-response effects; Genotypes; oxidative stress; Cancer; USA DO - http://dx.doi.org/10.1007/s10552-010-9613-7 ER - TY - JOUR T1 - Domestic violence against people with disabilities: Prevalence and trend analyses AN - 862591682; 201110151 AB - The present study analyzed national data from 'Domestic Violence Report System' derived primarily from the Council of Domestic Violence and Sexual Assaults Prevention, Ministry of the Interior, Taiwan, to describe the reported prevalence of domestic violence in people with disabilities and to examine the time-effect on the prevalence from years 2006 to 2009. The annual reported prevalence of domestic violence victims in people with disabilities was slightly lower than the general population. However, the reported rate changed significantly in people with disabilities over the period of 2006-2009, the victim number and rate (per ten-thousand) of reported cases in different years were 1260 (12.84), 1725 (16.90), 2163 (20.79) and 3157 (29.48). People with voice or speech disability, chronic psychosis and intellectual disability were the most domestic violence reported prevalence among the disabilities in the study. Those disabilities, such as chronic psychosis, intellectual disability, vision disability, hearing disability and multi-disabilities show increased significantly in annual reported rate in curve estimation for linear model over the period of 2006-2009. Finally, we found the average increase rate of annual reported prevalence in people of disabilities was 3.7 times of the general population (9.79% vs. 36.08%). Intellectual disability (41.52%), vision or speech disability (38.59%) and chronic psychosis (37.96%) were the most increasing disability type in average of annual reported prevalence of domestic violence among disabilities during the period of 2006-2009. The present study suggests health and welfare authorities should play vital roles in identifying and providing appropriate services for people with disabilities who encounter domestic violence. [Copyright Elsevier B.V.] JF - Research in Developmental Disabilities AU - Lin, Jin-Ding AU - Lin, Lan-Ping AU - Lin, Pei-Ying AU - Wu, Jia-Lin AU - Li, Chien-De AU - Kuo, Fang-Yu AD - School of Public Health, National Defense Medical Center, No. 161, Min-Chun East Road, Section 6, Nei-Hu, Taipei, Taiwan Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 1264 EP - 1268 PB - Elsevier Ltd, The Netherlands VL - 31 IS - 6 SN - 0891-4222, 0891-4222 KW - Domestic violence Violence People with disabilities KW - Disabled people KW - Learning disabilities KW - Domestic violence KW - Speech KW - Psychoses KW - Prevalence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862591682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+in+Developmental+Disabilities&rft.atitle=Domestic+violence+against+people+with+disabilities%3A+Prevalence+and+trend+analyses&rft.au=Lin%2C+Jin-Ding%3BLin%2C+Lan-Ping%3BLin%2C+Pei-Ying%3BWu%2C+Jia-Lin%3BLi%2C+Chien-De%3BKuo%2C+Fang-Yu&rft.aulast=Lin&rft.aufirst=Jin-Ding&rft.date=2010-11-01&rft.volume=31&rft.issue=6&rft.spage=1264&rft.isbn=&rft.btitle=&rft.title=Research+in+Developmental+Disabilities&rft.issn=08914222&rft_id=info:doi/10.1016%2Fj.ridd.2010.07.018 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Disabled people; Domestic violence; Prevalence; Psychoses; Learning disabilities; Speech DO - http://dx.doi.org/10.1016/j.ridd.2010.07.018 ER - TY - JOUR T1 - Probiotics: From Bench to Market AN - 861533794; 14196463 AB - Abstract not available. JF - Annals of the New York Academy of Sciences AU - Klein, Marguerite AU - Sanders, Mary Ellen AU - Duong, Tri AU - Young, Howard A AD - Office of Dietary Supplements, National Institutes of Health, Bethesda, Maryland. Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - E1 EP - E14 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 1212 SN - 0077-8923, 0077-8923 KW - Microbiology Abstracts B: Bacteriology KW - probiotics KW - J 02490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/861533794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Probiotics%3A+From+Bench+to+Market&rft.au=Klein%2C+Marguerite%3BSanders%2C+Mary+Ellen%3BDuong%2C+Tri%3BYoung%2C+Howard+A&rft.aulast=Klein&rft.aufirst=Marguerite&rft.date=2010-11-01&rft.volume=1212&rft.issue=&rft.spage=E1&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1111%2Fj.1749-6632.2010.05839.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Document feature - figure 1 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - probiotics DO - http://dx.doi.org/10.1111/j.1749-6632.2010.05839.x ER - TY - JOUR T1 - Fructose, uricase, and the back-to-Africa hypothesis AN - 861386063; 4181145 AB - In the Middle Miocene (approximately 17 to 12 Ma) at least two radiations of fossil apes from East Africa into Eurasia occurred, and, while controversial, some paleoanthropological studies suggest that one of the Eurasian lineages may have returned to Africa to evolve into humans and the African apes. Here, we present a novel argument supporting this hypothesis. Specifically, the global cooling that occurred in the middle Miocene rendered hominoids living in Europe at risk for starvation as seasonal climate change resulted in less availability of fruits during the winter months. During this time, a mutation in uricase occurred in early hominids that resulted in a rise in serum uric acid. Uric acid has been found to potentiate the effect of fructose to increase fat stores, suggesting that the mutation provided a survival advantage. Such a survival advantage would have been less likely to occur in Africa, where the continued presence of tropical rainforests would have been more likely to provide food throughout the year. Furthermore, Miocene apes in Europe were in protected sites where geographic isolation could have allowed the uricase mutation to be rapidly expressed in the entire population. While speculative, we suggest that the uricase mutation supports an extra-Africa origin of humans. Copyright John Wiley & Sons. Reproduced with permission. An electronic version of this article is available online at http://www.interscience.wiley.com JF - Evolutionary anthropology AU - Johnson, Richard J AU - Andrews, Peter AD - National Institutes of Health Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 250 EP - 257 VL - 19 IS - 6 SN - 1060-1538, 1060-1538 KW - Anthropology KW - Uricase KW - Eurasia KW - Geographic mobility KW - Paleoanthropology KW - Climate change KW - Evolutionary anthropology KW - Africa KW - Human origins KW - Food resources KW - Fossil primates KW - Primates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/861386063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Evolutionary+anthropology&rft.atitle=Fructose%2C+uricase%2C+and+the+back-to-Africa+hypothesis&rft.au=Johnson%2C+Richard+J%3BAndrews%2C+Peter&rft.aulast=Johnson&rft.aufirst=Richard&rft.date=2010-11-01&rft.volume=19&rft.issue=6&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Evolutionary+anthropology&rft.issn=10601538&rft_id=info:doi/10.1002%2Fevan.20266 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 6089 6091; 4563 1608 1077; 9114 1077; 10148; 5257 10148; 2382 2381 8560 9511 4309 4313; 5141; 5470 12092; 2 DO - http://dx.doi.org/10.1002/evan.20266 ER - TY - JOUR T1 - Radiolabeled antiviral drugs and antibodies as virus-specific imaging probes AN - 860372342; 13890047 AB - A number of small-molecule drugs inhibit viral replication by binding directly to virion structural proteins or to the active site of a viral enzyme, or are chemically modified by a viral enzyme before inhibiting a downstream process. Similarly, antibodies used to prevent or treat viral infections attach to epitopes on virions or on viral proteins expressed on the surface of infected cells. Such drugs and antibodies can therefore be thought of as probes for the detection of viral infections, suggesting that they might be used as radiolabeled tracers to visualize sites of viral replication by single-photon emission computed tomography (SPECT) or positron emission tomography (PET) imaging. A current example of this approach is the PET imaging of herpes simplex virus infections, in which the viral thymidine kinase phosphorylates radiolabeled thymidine analogues, trapping them within infected cells. One of many possible future applications might be the use of a radiolabeled hepatitis C protease inhibitor to image infection in animals or humans and provide a quantitative measure of viral burden. This article reviews the basic features of radionuclide imaging and the characteristics of ideal tracer molecules, and discusses how antiviral drugs and antibodies could be evaluated for their suitability as virus-specific imaging probes. The use of labeled drugs as low-dose tracers would provide an alternative application for compounds that have failed to advance to clinical use because of insufficient in vivo potency, an unsuitable pharmacokinetic profile or hepato- or nephrotoxicity. JF - Antiviral Research AU - Bray, Mike AU - Di Mascio, Michele AU - de Kok-Mercado, Fabian AU - Mollura, Daniel J AU - Jagoda, Elaine AD - Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD 21702, United States, mbray@niaid.nih.gov Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 129 EP - 142 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 88 IS - 2 SN - 0166-3542, 0166-3542 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Antibodies KW - Antiviral agents KW - Herpes simplex virus KW - A:01340 KW - V:22320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860372342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=Radiolabeled+antiviral+drugs+and+antibodies+as+virus-specific+imaging+probes&rft.au=Bray%2C+Mike%3BDi+Mascio%2C+Michele%3Bde+Kok-Mercado%2C+Fabian%3BMollura%2C+Daniel+J%3BJagoda%2C+Elaine&rft.aulast=Bray&rft.aufirst=Mike&rft.date=2010-11-01&rft.volume=88&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2010.08.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Antiviral agents; Herpes simplex virus DO - http://dx.doi.org/10.1016/j.antiviral.2010.08.005 ER - TY - JOUR T1 - Reversibility of object recognition but not spatial memory impairment following binge-like alcohol exposure in rats AN - 858422666; 14039171 AB - a-[ordm Binge-like alcohol exposure leads to neurotoxicity in several brain structures. a-[ordm Alcohol bingeing produces long-term impairment of spatial memory. a-[ordm Reversibility of the object recognition impairment following binge-like alcohol exposure. a-[ordm OET is a useful experimental paradigm to assess spatial learning and memory damage. Excessive alcohol use leads to neurodegeneration in several brain structures including the hippocampal dentate gyrus and the entorhinal cortex. Cognitive deficits that result are among the most insidious and debilitating consequences of alcoholism. The object exploration task (OET) provides a sensitive measurement of spatial memory impairment induced by hippocampal and cortical damage. In this study, we examine whether the observed neurotoxicity produced by a 4-day binge ethanol treatment results in long-term memory impairment by observing the time course of reactions to spatial change (object configuration) and non-spatial change (object recognition). Wistar rats were assessed for their abilities to detect spatial configuration in the OET at 1week and 10weeks following the ethanol treatment, in which ethanol groups received 9-15g/kg/day and achieved blood alcohol levels over 300mg/dl. At 1week, results indicated that the binge alcohol treatment produced impairment in both spatial memory and non-spatial object recognition performance. Unlike the controls, ethanol treated rats did not increase the duration or number of contacts with the displaced object in the spatial memory task, nor did they increase the duration of contacts with the novel object in the object recognition task. After 10weeks, spatial memory remained impaired in the ethanol treated rats but object recognition ability was recovered. Our data suggest that episodes of binge-like alcohol exposure result in long-term and possibly permanent impairments in memory for the configuration of objects during exploration, whereas the ability to detect non-spatial changes is only temporarily affected. JF - Neurobiology of Learning and Memory AU - Cippitelli, Andrea AU - Zook, Michelle AU - Bell, Lauren AU - Damadzic, Ruslan AU - Eskay, Robert L AU - Schwandt, Melanie AU - Heilig, Markus AD - Laboratory of Clinical and Translational Studies (LCTS), National Institute of Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH) Bethesda, MD 20892, United States, cippitellia@mail.nih.gov Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 538 EP - 546 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 94 IS - 4 SN - 1074-7427, 1074-7427 KW - Toxicology Abstracts; CSA Neurosciences Abstracts; Animal Behavior Abstracts KW - Cortex (entorhinal) KW - Data processing KW - Long term memory KW - Hippocampus KW - Brain KW - Drug abuse KW - Neurodegeneration KW - Dentate gyrus KW - spatial memory KW - Pattern recognition KW - Blood KW - Nervous system KW - Cognitive ability KW - Alcoholism KW - Neurotoxicity KW - Exploration KW - Spatial discrimination learning KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25070:Learning, Memory, Reinforcement, and Motivation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/858422666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurobiology+of+Learning+and+Memory&rft.atitle=Reversibility+of+object+recognition+but+not+spatial+memory+impairment+following+binge-like+alcohol+exposure+in+rats&rft.au=Cippitelli%2C+Andrea%3BZook%2C+Michelle%3BBell%2C+Lauren%3BDamadzic%2C+Ruslan%3BEskay%2C+Robert+L%3BSchwandt%2C+Melanie%3BHeilig%2C+Markus&rft.aulast=Cippitelli&rft.aufirst=Andrea&rft.date=2010-11-01&rft.volume=94&rft.issue=4&rft.spage=538&rft.isbn=&rft.btitle=&rft.title=Neurobiology+of+Learning+and+Memory&rft.issn=10747427&rft_id=info:doi/10.1016%2Fj.nlm.2010.09.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Cortex (entorhinal); Data processing; Hippocampus; Long term memory; Brain; Drug abuse; Neurodegeneration; Dentate gyrus; spatial memory; Blood; Pattern recognition; Nervous system; Cognitive ability; Neurotoxicity; Alcoholism; Exploration; Spatial discrimination learning; Ethanol DO - http://dx.doi.org/10.1016/j.nlm.2010.09.006 ER - TY - JOUR T1 - Mechanism of Positive Regulation by DsrA and RprA Small Noncoding RNAs: Pairing Increases Translation and Protects rpoS mRNA from Degradation AN - 858422185; 13821141 AB - Small noncoding RNAs (sRNAs) regulate gene expression in Escherichia coli by base pairing with mRNAs and modulating translation and mRNA stability. The sRNAs DsrA and RprA stimulate the translation of the stress response transcription factor RpoS by base pairing with the 5' untranslated region of the rpoS mRNA. In the present study, we found that the rpoS mRNA was unstable in the absence of DsrA and RprA and that expression of these sRNAs increased both the accumulation and the half-life of the rpoS mRNA. Mutations in dsrA, rprA, or rpoS that disrupt the predicted pairing sequences and reduce translation of RpoS also destabilize the rpoS mRNA. We found that the rpoS mRNA accumulates in an RNase E mutant strain in the absence of sRNA expression and, therefore, is degraded by an RNase E-mediated mechanism. DsrA expression is required, however, for maximal translation even when rpoS mRNA is abundant. This suggests that DsrA protects rpoS mRNA from degradation by RNase E and that DsrA has a further activity in stimulating RpoS protein synthesis. rpoS mRNA is subject to degradation by an additional pathway, mediated by RNase III, which, in contrast to the RNase E-mediated pathway, occurs in the presence and absence of DsrA or RprA. rpoS mRNA and RpoS protein levels are increased in an RNase III mutant strain with or without the sRNAs, suggesting that the role of RNase III in this context is to reduce the translation of RpoS even when the sRNAs are acting to stimulate translation. JF - Journal of Bacteriology AU - McCullen, Colleen A AU - Benhammou, Jihane N AU - Majdalani, Nadim AU - Gottesman, Susan AD - Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, susang@helix.nih.gov Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 5559 EP - 5571 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 192 IS - 21 SN - 0021-9193, 0021-9193 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Translation KW - mRNA stability KW - Protein biosynthesis KW - Transcription KW - Stress KW - Gene expression KW - ribonuclease E KW - Transcription factors KW - Escherichia coli KW - Ribonuclease III KW - Ribonuclease KW - Mutation KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/858422185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Mechanism+of+Positive+Regulation+by+DsrA+and+RprA+Small+Noncoding+RNAs%3A+Pairing+Increases+Translation+and+Protects+rpoS+mRNA+from+Degradation&rft.au=McCullen%2C+Colleen+A%3BBenhammou%2C+Jihane+N%3BMajdalani%2C+Nadim%3BGottesman%2C+Susan&rft.aulast=McCullen&rft.aufirst=Colleen&rft.date=2010-11-01&rft.volume=192&rft.issue=21&rft.spage=5559&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.00464-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Number of references - 64 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Gene expression; Translation; mRNA stability; Protein biosynthesis; ribonuclease E; Transcription factors; Stress; Transcription; Ribonuclease; Ribonuclease III; Mutation; Escherichia coli DO - http://dx.doi.org/10.1128/JB.00464-10 ER - TY - JOUR T1 - Trichoderma harzianum IOC-4038: A Promising Strain for the Production of a Cellulolytic Complex with Significant beta -Glucosidase Activity from Sugarcane Bagasse Cellulignin AN - 856768827; 14232733 AB - Sugarcane bagasse is an agroindustrial residue generated in large amounts in Brazil. This biomass can be used for the production of cellulases, aiming at their use in second-generation processes for bioethanol production. Therefore, this work reports the ability of a fungal strain, Trichoderma harzianum IOC-4038, to produce cellulases on a novel material, xylan free and cellulose rich, generated from sugarcane bagasse, named partially delignified cellulignin. The extract produced by T. harzianum under submerged conditions reached 745, 97, and 559 U L super(-1) of beta -glucosidase, FPase, and endoglucanase activities, respectively. The partial characterization of this enzyme complex indicated, using a dual analysis, that the optimal pH values for the biocatalysis ranged from 4.9 to 5.2 and optimal temperatures were between 47 and 54 degree C, depending on the activity studied. Thermal stability analyses revealed no significant decrease in activity at 37 degree C during 23h of incubation. When compared to model strains, Aspergillus niger ATCC-16404 and Trichoderma reesei RutC30, T. harzianum fermentation was faster and its extract showed a better balanced enzyme complex, with adequate characteristics for its application in simultaneous saccharification and fermentation processes. JF - Applied Biochemistry and Biotechnology AU - Castro, Aline Machado AU - Pedro, Kelly Cristina Nascimento Rodrigues AU - Cruz, Juliana Cunha AU - Ferreira, Marcela Costa AU - Leite, Selma Gomes Ferreira AU - Pereira, Nei AD - Biochemical Engineering Department, School of Chemistry, Federal University of Rio de Janeiro, P.O. Box68542, Rio de Janeiro, 21941-598, RJ, Brazil, nei@eq.ufrj.br Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 2111 EP - 2122 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 162 IS - 7 SN - 0273-2289, 0273-2289 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Endoglucanase KW - Fermentation KW - Cellulose KW - Enzymes KW - Biomass KW - Cellulase KW - Bagasse KW - Xylan KW - Hypocrea jecorina KW - beta -Glucosidase KW - Thermal stability KW - pH effects KW - Aspergillus niger KW - Biofuels KW - Catalysis KW - Ethanol KW - W 30945:Fermentation & Cell Culture KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856768827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Biochemistry+and+Biotechnology&rft.atitle=Trichoderma+harzianum+IOC-4038%3A+A+Promising+Strain+for+the+Production+of+a+Cellulolytic+Complex+with+Significant+beta+-Glucosidase+Activity+from+Sugarcane+Bagasse+Cellulignin&rft.au=Castro%2C+Aline+Machado%3BPedro%2C+Kelly+Cristina+Nascimento+Rodrigues%3BCruz%2C+Juliana+Cunha%3BFerreira%2C+Marcela+Costa%3BLeite%2C+Selma+Gomes+Ferreira%3BPereira%2C+Nei&rft.aulast=Castro&rft.aufirst=Aline&rft.date=2010-11-01&rft.volume=162&rft.issue=7&rft.spage=2111&rft.isbn=&rft.btitle=&rft.title=Applied+Biochemistry+and+Biotechnology&rft.issn=02732289&rft_id=info:doi/10.1007%2Fs12010-010-8986-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2013-12-04 N1 - SubjectsTermNotLitGenreText - Endoglucanase; Temperature effects; Fermentation; Cellulose; Enzymes; Biomass; Cellulase; Bagasse; Xylan; Thermal stability; beta -Glucosidase; pH effects; Biofuels; Ethanol; Catalysis; Hypocrea jecorina; Aspergillus niger DO - http://dx.doi.org/10.1007/s12010-010-8986-0 ER - TY - JOUR T1 - An insight into the sialome of blood-feeding Nematocera AN - 856758699; 13972258 AB - Within the Diptera and outside the suborder Brachycera, the blood-feeding habit occurred at least twice, producing the present day sand flies, and the Culicomorpha, including the mosquitoes (Culicidae), black flies (Simulidae), biting midges (Ceratopogonidae) and frog feeding flies (Corethrellidae). Alternatives to this scenario are also discussed. Successful blood-feeding requires adaptations to antagonize the vertebrate's mechanisms of blood clotting, platelet aggregation, vasoconstriction, pain and itching, which are triggered by tissue destruction and immune reactions to insect products. Saliva of these insects provides a complex pharmacological armamentarium to block these vertebrate reactions. With the advent of transcriptomics, the sialomes (from the Greek word sialoaa=aasaliva) of at least two species of each of these families have been studied (except for the frog feeders), allowing an insight into the diverse pathways leading to today's salivary composition within the Culicomorpha, having the sand flies as an outgroup. This review catalogs 1288 salivary proteins in 10 generic classes comprising over 150 different protein families, most of which we have no functional knowledge. These proteins and many sequence comparisons are displayed in a hyperlinked spreadsheet that hopefully will stimulate and facilitate the task of functional characterization of these proteins, and their possible use as novel pharmacological agents and epidemiological markers of insect vector exposure. JF - Insect Biochemistry and Molecular Biology AU - Ribeiro, Jose MC AU - Mans, Ben J AU - Arca, Bruno AD - Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, 12735 Twinbrook Parkway, Room 2E32D, Rockville MD 20852, USA Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 767 EP - 784 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 40 IS - 11 SN - 0965-1748, 0965-1748 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Entomology Abstracts KW - Salivary glands KW - Hematophagy KW - Mosquitoes KW - Sand flies KW - Black flies KW - Biting midges KW - Feeding KW - Vector KW - Catalogs KW - Amphibiotic species KW - Platelet aggregation KW - Nucleotide sequence KW - Catalogues KW - Pain KW - Public health KW - Molecular biology KW - Brachycera KW - Nematocera KW - Aquatic insects KW - Adaptations KW - Anura KW - Vectors KW - protein families KW - Culicidae KW - Culicomorpha KW - Vasoconstriction KW - Ceratopogonidae KW - Blood KW - Corethrellidae KW - Blood coagulation KW - Biting KW - Saliva KW - Diptera KW - Antimicrobial peptides KW - Evolution KW - Q1 08484:Species interactions: parasites and diseases KW - Z 05320:Physiology, Anatomy, and Biochemistry KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856758699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Insect+Biochemistry+and+Molecular+Biology&rft.atitle=An+insight+into+the+sialome+of+blood-feeding+Nematocera&rft.au=Ribeiro%2C+Jose+MC%3BMans%2C+Ben+J%3BArca%2C+Bruno&rft.aulast=Ribeiro&rft.aufirst=Jose&rft.date=2010-11-01&rft.volume=40&rft.issue=11&rft.spage=767&rft.isbn=&rft.btitle=&rft.title=Insect+Biochemistry+and+Molecular+Biology&rft.issn=09651748&rft_id=info:doi/10.1016%2Fj.ibmb.2010.08.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2014-11-12 N1 - SubjectsTermNotLitGenreText - Molecular biology; Adaptations; Amphibiotic species; Nucleotide sequence; Catalogues; Aquatic insects; Public health; Feeding; Catalogs; Platelet aggregation; protein families; Vectors; Pain; Vasoconstriction; Blood; Blood coagulation; Biting; Saliva; Antimicrobial peptides; Evolution; Ceratopogonidae; Corethrellidae; Brachycera; Nematocera; Anura; Culicomorpha; Culicidae; Diptera DO - http://dx.doi.org/10.1016/j.ibmb.2010.08.002 ER - TY - JOUR T1 - Robust and accurate data enrichment statistics via distribution function of sum of weights AN - 855686034; 14086599 AB - Motivation: Term-enrichment analysis facilitates biological interpretation by assigning to experimentally/computationally obtained data annotation associated with terms from controlled vocabularies. This process usually involves obtaining statistical significance for each vocabulary term and using the most significant terms to describe a given set of biological entities, often associated with weights. Many existing enrichment methods require selections of (arbitrary number of) the most significant entities and/or do not account for weights of entities. Others either mandate extensive simulations to obtain statistics or assume normal weight distribution. In addition, most methods have difficulty assigning correct statistical significance to terms with few entities.Results: Implementing the well-known Lugananni-Rice formula, we have developed a novel approach, called SaddleSum, that is free from all the aforementioned constraints and evaluated it against several existing methods. With entity weights properly taken into account, SaddleSum is internally consistent and stable with respect to the choice of number of most significant entities selected. Making few assumptions on the input data, the proposed method is universal and can thus be applied to areas beyond analysis of microarrays. Employing asymptotic approximation, SaddleSum provides a term-size-dependent score distribution function that gives rise to accurate statistical significance even for terms with few entities. As a consequence, SaddleSum enables researchers to place confidence in its significance assignments to small terms that are often biologically most specific. JF - Bioinformatics AU - Stojmirovic, Aleksandar AU - Yu, Yi-Kuo AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA Y1 - 2010/11/01/ PY - 2010 DA - 2010 Nov 01 SP - 2752 EP - 2759 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 26 IS - 21 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Statistics KW - Statistical analysis KW - Bioinformatics KW - Manganese KW - Internet KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855686034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Robust+and+accurate+data+enrichment+statistics+via+distribution+function+of+sum+of+weights&rft.au=Stojmirovic%2C+Aleksandar%3BYu%2C+Yi-Kuo&rft.aulast=Stojmirovic&rft.aufirst=Aleksandar&rft.date=2010-11-01&rft.volume=26&rft.issue=21&rft.spage=2752&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtq511 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Statistics; Data processing; Statistical analysis; Bioinformatics; Manganese; Internet DO - http://dx.doi.org/10.1093/bioinformatics/btq511 ER - TY - JOUR T1 - Click-words: learning to predict document keywords from a user perspective AN - 855685160; 14086577 AB - Motivation: Recognizing words that are key to a document is important for ranking relevant scientific documents. Traditionally, important words in a document are either nominated subjectively by authors and indexers or selected objectively by some statistical measures. As an alternative, we propose to use documents' words popularity in user queries to identify click-words, a set of prominent words from the users' perspective. Although they often overlap, click-words differ significantly from other document keywords.Results: We developed a machine learning approach to learn the unique characteristics of click-words. Each word was represented by a set of features that included different types of information, such as semantic type, part of speech tag, term frequency-inverse document frequency (TF-IDF) weight and location in the abstract. We identified the most important features and evaluated our model using 6 months of PubMed click-through logs. Our results suggest that, in addition to carrying high TF-IDF weight, click-words tend to be biomedical entities, to exist in article titles, and to occur repeatedly in article abstracts. Given the abstract and title of a document, we are able to accurately predict the words likely to appear in user queries that lead to document clicks. JF - Bioinformatics AU - Islamaj Dogan, Rezarta AU - Lu, Zhiyong AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA Y1 - 2010/11/01/ PY - 2010 DA - 2010 Nov 01 SP - 2767 EP - 2775 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 26 IS - 21 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - speech KW - Learning KW - Statistics KW - Data processing KW - Bioinformatics KW - Learning algorithms KW - Internet KW - Semantics KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855685160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Click-words%3A+learning+to+predict+document+keywords+from+a+user+perspective&rft.au=Islamaj+Dogan%2C+Rezarta%3BLu%2C+Zhiyong&rft.aulast=Islamaj+Dogan&rft.aufirst=Rezarta&rft.date=2010-11-01&rft.volume=26&rft.issue=21&rft.spage=2767&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtq459 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Learning; speech; Data processing; Statistics; Learning algorithms; Bioinformatics; Internet; Models; Semantics DO - http://dx.doi.org/10.1093/bioinformatics/btq459 ER - TY - JOUR T1 - The Antiretroviral Lectin Cyanovirin-N Targets Well-Known and Novel Targets on the Surface of Entamoeba histolytica Trophozoites AN - 853480213; 13960351 AB - Entamoeba histolytica, the protist that causes amebic dysentery and liver abscess, has a truncated Asn-linked glycan (N-glycan) precursor composed of seven sugars (Man5GlcNAc2). Here, we show that glycoproteins with unmodified N-glycans are aggregated and capped on the surface of E. histolytica trophozoites by the antiretroviral lectin cyanovirin-N and then replenished from large intracellular pools. Cyanovirin-N cocaps the Gal/GalNAc adherence lectin, as well as glycoproteins containing O-phosphodiester-linked glycans recognized by an anti-proteophosphoglycan monoclonal antibody. Cyanovirin-N inhibits phagocytosis by E. histolytica trophozoites of mucin-coated beads, a surrogate assay for amebic virulence. For technical reasons, we used the plant lectin concanavalin A rather than cyanovirin-N to enrich secreted and membrane proteins for mass spectrometric identification. E. histolytica glycoproteins with occupied N-glycan sites include Gal/GalNAc lectins, proteases, and 17 previously hypothetical proteins. The latter glycoproteins, as well as 50 previously hypothetical proteins enriched by concanavalin A, may be vaccine targets as they are abundant and unique. In summary, the antiretroviral lectin cyanovirin-N binds to well-known and novel targets on the surface of E. histolytica that are rapidly replenished from large intracellular pools. JF - Eukaryotic Cell AU - Carpentieri, Andrea AU - Ratner, Daniel M AU - Ghosh, Sudip K AU - Banerjee, Sulagna AU - Bushkin, GGuy AU - Cui, Jike AU - Lubrano, Michael AU - Steffen, Martin AU - Costello, Catherine E AU - O'Keefe, Barry AD - Molecular Targets Development Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702, jsamuels@bu.edu Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1661 EP - 1668 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 9 IS - 11 SN - 1535-9786, 1535-9786 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Abscesses KW - Antiviral agents KW - Concanavalin A KW - Dysentery KW - Glycoproteins KW - Lectins KW - Liver KW - Membrane proteins KW - Monoclonal antibodies KW - N-glycans KW - Phagocytosis KW - Polysaccharides KW - Proteinase KW - Sugar KW - Trophozoites KW - Vaccines KW - Virulence KW - cyanovirin-N KW - Entamoeba histolytica KW - W 30915:Pharmaceuticals & Vaccines KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853480213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eukaryotic+Cell&rft.atitle=The+Antiretroviral+Lectin+Cyanovirin-N+Targets+Well-Known+and+Novel+Targets+on+the+Surface+of+Entamoeba+histolytica+Trophozoites&rft.au=Carpentieri%2C+Andrea%3BRatner%2C+Daniel+M%3BGhosh%2C+Sudip+K%3BBanerjee%2C+Sulagna%3BBushkin%2C+GGuy%3BCui%2C+Jike%3BLubrano%2C+Michael%3BSteffen%2C+Martin%3BCostello%2C+Catherine+E%3BO%27Keefe%2C+Barry&rft.aulast=Carpentieri&rft.aufirst=Andrea&rft.date=2010-11-01&rft.volume=9&rft.issue=11&rft.spage=1661&rft.isbn=&rft.btitle=&rft.title=Eukaryotic+Cell&rft.issn=15359786&rft_id=info:doi/10.1128%2FEC.00166-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Number of references - 56 N1 - Last updated - 2012-12-28 N1 - SubjectsTermNotLitGenreText - Sugar; Monoclonal antibodies; Lectins; Membrane proteins; Polysaccharides; Abscesses; Virulence; cyanovirin-N; Concanavalin A; Antiviral agents; Dysentery; N-glycans; Liver; Proteinase; Glycoproteins; Vaccines; Phagocytosis; Trophozoites; Entamoeba histolytica DO - http://dx.doi.org/10.1128/EC.00166-10 ER - TY - JOUR T1 - Multiple Antigen Peptide Vaccines against Plasmodium falciparum Malaria AN - 853475925; 13885345 AB - The multiple antigen peptide (MAP) approach is an effective method to chemically synthesize and deliver multiple T-cell and B-cell epitopes as the constituents of a single immunogen. Here we report on the design, chemical synthesis, and immunogenicity of three Plasmodium falciparum MAP vaccines that incorporated antigenic epitopes from the sporozoite, liver, and blood stages of the life cycle. Antibody and cellular responses were determined in three inbred (C57BL/6, BALB/c, and A/J) strains, one congenic (HLA-A2 on the C57BL/6 background) strain, and one outbred strain (CD1) of mice. All three MAPs were immunogenic and induced both antibody and cellular responses, albeit in a somewhat genetically restricted manner. Antibodies against MAP-1, MAP-2, and MAP-3 had an antiparasite effect that was also dependent on the mouse major histocompatibility complex background. Anti-MAP-1 (CSP-based) antibodies blocked the invasion of HepG2 liver cells by P. falciparum sporozoites (highest, 95.16% in HLA-A2 C57BL/6; lowest, 11.21% in BALB/c). Furthermore, antibodies generated following immunizations with the MAP-2 (PfCSP, PfLSA-1, PfMSP-142, and PfMSP-3b) and MAP-3 (PfRAP-1, PfRAP-2, PfSERA, and PfMSP-142) vaccines were able to reduce the growth of blood stage parasites in erythrocyte cultures to various degrees. Thus, MAP-based vaccines remain a viable option to induce effective antibody and cellular responses. These results warrant further development and preclinical and clinical testing of the next generation of candidate MAP vaccines that are based on the conserved protective epitopes from Plasmodium antigens that are widely recognized by populations of divergent HLA types from around the world. JF - Infection and Immunity AU - Mahajan, Babita AU - Berzofsky, Jay A AU - Boykins, Robert A AU - Majam, Victoria AU - Zheng, Hong AU - Chattopadhyay, Rana AU - la Vega, Patricia de AU - Moch, JKathleen AU - Haynes, JDavid AU - Belyakov, Igor M AD - Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, Sanjai.kumar@fda.hhs.gov Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 4613 EP - 4624 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 78 IS - 11 SN - 0019-9567, 0019-9567 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts KW - Histocompatibility antigen HLA KW - Parasites KW - Hepatocytes KW - Erythrocytes KW - Disease control KW - Life cycle KW - Major histocompatibility complex KW - Cell culture KW - Malaria KW - Public health KW - Antigens KW - Lymphocytes T KW - Epitopes KW - Lymphocytes B KW - Sporozoites KW - Plasmodium falciparum KW - Immunization KW - Blood KW - Antibodies KW - Immunogenicity KW - Liver KW - Inbreeding KW - Peptides KW - Vaccines KW - K 03350:Immunology KW - Q1 08485:Species interactions: pests and control KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853475925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Multiple+Antigen+Peptide+Vaccines+against+Plasmodium+falciparum+Malaria&rft.au=Mahajan%2C+Babita%3BBerzofsky%2C+Jay+A%3BBoykins%2C+Robert+A%3BMajam%2C+Victoria%3BZheng%2C+Hong%3BChattopadhyay%2C+Rana%3Bla+Vega%2C+Patricia+de%3BMoch%2C+JKathleen%3BHaynes%2C+JDavid%3BBelyakov%2C+Igor+M&rft.aulast=Mahajan&rft.aufirst=Babita&rft.date=2010-11-01&rft.volume=78&rft.issue=11&rft.spage=4613&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00533-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Number of references - 63 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Parasites; Antibodies; Antigens; Disease control; Peptides; Vaccines; Public health; Histocompatibility antigen HLA; Lymphocytes B; Hepatocytes; Erythrocytes; Sporozoites; Major histocompatibility complex; Life cycle; Malaria; Cell culture; Immunization; Blood; Immunogenicity; Liver; Lymphocytes T; Inbreeding; Epitopes; Plasmodium falciparum DO - http://dx.doi.org/10.1128/IAI.00533-10 ER - TY - JOUR T1 - Virtue ethics and the selection of children with impairments: a reply to Rosalind McDougall AN - 848677949; 4157944 AB - In 'Parental Virtues: A New Way of Thinking about the Morality of Reproductive Actions' Rosalind McDougall proposes a virtue-based framework to assess the morality of child selection. Applying the virtue-based account to the selection of children with impairments does not lead, according to McDougall, to an unequivocal answer to the morality of selecting impaired children. In 'Impairment, Flourishing, and the Moral Nature of Parenthood,' she also applies the virtue-based account to the discussion of child selection, and claims that couples with an impairment are morally justified in selecting a child with the same impairment. This claim, she maintains, reveals that the flourishing of a child should be understood as requiring environment-specific characteristics. I argue that McDougall's argument begs the question. More importantly, it does not do justice to virtue ethics. I also question to what extent a virtue ethics framework can be successfully applied to discussions about the moral permissibility of reproductive actions. Adapted from the source document. Reprinted by permission of Blackwell Publishers JF - Bioethics AU - Saenz, Carla AD - National Institutes of Health Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 499 EP - 506 VL - 24 IS - 9 SN - 0269-9702, 0269-9702 KW - Sociology KW - Anthropology KW - Morality KW - Preferences KW - Abortion KW - Ethics KW - Disability KW - Children UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/848677949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioethics&rft.atitle=Virtue+ethics+and+the+selection+of+children+with+impairments%3A+a+reply+to+Rosalind+McDougall&rft.au=Saenz%2C+Carla&rft.aulast=Saenz&rft.aufirst=Carla&rft.date=2010-11-01&rft.volume=24&rft.issue=9&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=Bioethics&rft.issn=02699702&rft_id=info:doi/10.1111%2Fj.1467-8519.2009.01732.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4408 8282 8281 6085; 2212; 10016; 3584 1678; 495 4773; 8281 6085 DO - http://dx.doi.org/10.1111/j.1467-8519.2009.01732.x ER - TY - JOUR T1 - An Update of Cancer Incidence in the Agricultural Health Study AN - 839709314; 14029603 AB - Objective: Our objective is to reevaluate cancer incidence among Agricultural Health Study participants. Methods: Standardized incidence ratios (SIRs) and relative standardized ratios were calculated. Results: A significant excess of prostate cancer was seen for private and commercial applicators (SIR = 1.19, 95% CI 1.14, 1.25 and SIR = 1.28, 95% CI = 1.00, 1.61, respectively). Excesses were observed for lip cancer (SIR = 1.97, 95% CI = 1.02, 3.44) and multiple myeloma (SIR = 1.42, 95% CI = 1.00, 1.95) among private applicators from North Carolina and for marginal zone lymphoma among Iowa spouses (SIR = 2.34, 95% CI = 1.21, 4.09). Conclusions: Although lower rates of smoking and increased physical activity probably contribute to the lower overall cancer incidence, agricultural exposures including pesticides, viruses, bacteria, sunlight, and other chemicals may increase risks for specific cancer sites. JF - Journal of Occupational and Environmental Medicine AU - Koutros, S AU - Alavanja, MCR AU - Lubin, J H AU - Sandler, D P AU - Hoppin, JA AU - Lynch, C F AU - Knott, C AU - Blair, A AU - Freeman, LEB AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., EPS 8115, MSC 7240, Rockville, MD 20852, USA, koutross@mail.nih.gov Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1098 EP - 1105 VL - 52 IS - 11 SN - 1076-2752, 1076-2752 KW - Risk Abstracts KW - Chemicals KW - USA, North Carolina KW - Smoking KW - USA, Iowa KW - multiple myeloma KW - Viruses KW - Pesticides KW - Standards KW - sunlight KW - prostate cancer KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839709314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=An+Update+of+Cancer+Incidence+in+the+Agricultural+Health+Study&rft.au=Koutros%2C+S%3BAlavanja%2C+MCR%3BLubin%2C+J+H%3BSandler%2C+D+P%3BHoppin%2C+JA%3BLynch%2C+C+F%3BKnott%2C+C%3BBlair%2C+A%3BFreeman%2C+LEB&rft.aulast=Koutros&rft.aufirst=S&rft.date=2010-11-01&rft.volume=52&rft.issue=11&rft.spage=1098&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181f72b7c LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2014-05-29 N1 - SubjectsTermNotLitGenreText - Chemicals; Smoking; multiple myeloma; Pesticides; Viruses; Standards; prostate cancer; sunlight; Cancer; USA, North Carolina; USA, Iowa DO - http://dx.doi.org/10.1097/JOM.0b013e3181f72b7c ER - TY - JOUR T1 - Priorities of Low-Income Urban Residents for Interventions to Address the Socio-Economic Determinants of Health AN - 839603376; 201100888 AB - Objectives. To determine the priorities of low-income urban residents for interventions that address the socio-economic determinants of health. Methods. We selected and estimated the cost of 16 interventions related to education, housing, nutrition, employment, health care, healthy behavior, neighborhood improvement, and transportation. Low-income residents of Washington, D.C. (N=431) participated in decision exercises to prioritize these interventions. Results. Given a budget valued at approximately twice an estimated cost of medical and dental care ($885), the interventions ultimately prioritized by the greatest percentage of individuals were: health insurance (95%), housing vouchers (82%) dental care (82%), job training (72%), adult education (63%), counseling (68%), healthy behavior incentives (68%), and job placement (67%). The percentages of respondents who received support for housing, adult education, and job training and placement were far less than the percentage who prioritized these interventions. Conclusions. Poor and low-income residents' priorities may usefully inform allocation of social services that affect health. Adapted from the source document. JF - Journal of Health Care for the Poor and Underserved AU - Danis, Marion AU - Kotwani, Namrata AU - Garrett, Joanne AU - Rivera, Ivonne AU - Davies-Cole, John AU - Carter-Nolan, Pamela AD - Chief, Bioethics Consultation Service, Dept. of Bioethics; Clinical Center, National Institutes of Health, Bldg. 10, Rm. 1C118, Bethesda, MD 20892-1156; (301) 435-8727 mdanis@nih.gov Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 1318 EP - 1339 PB - John Hopkins University Press, Baltimore MD VL - 21 IS - 4 SN - 1049-2089, 1049-2089 KW - Health status disparity, health promotion, poverty, resource allocation, public participation KW - Adult education KW - Housing KW - Interventions KW - Priorities KW - Health KW - Low income people KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839603376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=Priorities+of+Low-Income+Urban+Residents+for+Interventions+to+Address+the+Socio-Economic+Determinants+of+Health&rft.au=Danis%2C+Marion%3BKotwani%2C+Namrata%3BGarrett%2C+Joanne%3BRivera%2C+Ivonne%3BDavies-Cole%2C+John%3BCarter-Nolan%2C+Pamela&rft.aulast=Danis&rft.aufirst=Marion&rft.date=2010-11-01&rft.volume=21&rft.issue=4&rft.spage=1318&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Interventions; Low income people; Priorities; Health; Housing; Adult education ER - TY - JOUR T1 - Sociodemographic Characteristics of Cannabis Smokers and the Experience of Cannabis Withdrawal AN - 839600568; 201100790 AB - Background: Cannabis withdrawal can be a negative reinforcer for relapse, but little is known about its association with demographic characteristics. Objectives: Evaluate the association of demographic characteristics with the experience of cannabis withdrawal. Methods: Retrospective self-report of a "serious" cannabis quit attempt without formal treatment in a convenience sample of 104 non-treatment-seeking, adult cannabis smokers (mean age 35 years, 52% white, 78% male) with no other current substance use disorder (except tobacco) or chronic health problems. Reasons for quitting, coping strategies to help quit, and 18 specific withdrawal symptoms were assessed by questionaire. Results: Among withdrawal symptoms, only anxiety, increased sex drive, and craving showed significant associations with age, race, or sex. Women were more likely than men to report a physical withdrawal symptom (OR = 3.2, 95% CI = .99-10.4, p = .05), especially upset stomach. There were few significant demographic associations with coping strategies or reasons for quitting. Conclusions and Scientific Significance: This small study suggests that there are few robust associations between demographic characteristics and cannabis withdrawal. Future studies with larger samples are needed. Attention to physical withdrawal symptoms in women may help promote abstinence. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Copersino, Marc L AU - Boyd, Susan J AU - Tashkin, Donald P AU - Huestis, Marilyn A AU - Heishman, Stephen J AU - Dermand, John C AU - Simmons, Michael S AU - Gorelick, David A AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 311 EP - 319 PB - Taylor & Francis Inc., Philadelphia, PA VL - 36 IS - 6 SN - 0095-2990, 0095-2990 KW - Age cannabis marijuana quitting race relapse sex withdrawal KW - Coping strategies KW - Cessation KW - Cannabis KW - Withdrawal symptoms KW - Demographic aspects KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839600568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Sociodemographic+Characteristics+of+Cannabis+Smokers+and+the+Experience+of+Cannabis+Withdrawal&rft.au=Copersino%2C+Marc+L%3BBoyd%2C+Susan+J%3BTashkin%2C+Donald+P%3BHuestis%2C+Marilyn+A%3BHeishman%2C+Stephen+J%3BDermand%2C+John+C%3BSimmons%2C+Michael+S%3BGorelick%2C+David+A&rft.aulast=Copersino&rft.aufirst=Marc&rft.date=2010-11-01&rft.volume=36&rft.issue=6&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/10.3109%2F00952990.2010.503825 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - AJDABD N1 - SubjectsTermNotLitGenreText - Cannabis; Withdrawal symptoms; Demographic aspects; Coping strategies; Cessation DO - http://dx.doi.org/10.3109/00952990.2010.503825 ER - TY - JOUR T1 - Age-associated differences in the gait pattern changes of older adults during fast-speed and fatigue conditions: results from the Baltimore longitudinal study of ageing AN - 839573353; 201102247 AB - OBJECTIVE: the present study investigated the effects of walking under different challenges and kinematics and kinetics generated during these activities and how these vary with age. We hypothesised that age-associated changes in gait speed and kinetics are more pronounced during fast-speed walking and post-activity walking, compared with usual-speed walking. METHODS: investigated walking under three conditions: (i) usual speed, (ii) fast speed and (iii) post-activity in 183 Baltimore Longitudinal Study of Aging participants (mean 73 ^c 9 years) who could walk unassisted. RESULTS: across all tasks, gait speed decreased with older age and this decline rate was exacerbated in the fast-speed walking task, compared with usual-speed walking (P < 0.001). Medial-lateral (ML) hip-generative mechanical work expenditure declined with age and the rate of decline was steeper for walking at fast speed and post-activity during hip extension (P = 0.032 and 0.027, respectively), compared with usual-speed walking. CONCLUSIONS: these findings indicate that older adults experience exacerbated declines in gait speed and ML control of the hip, which is explicitly evident during challenging walking. Exercise programmes aimed at improving gait speed and ML joint power from hip and ankle may help reverse age-associated changes in gait pattern among older adults. Adapted from the source document. JF - Age and Ageing AU - Ko, Seung-uk AU - Hausdorff, Jeffrey M AU - Ferrucci, Luigi AD - National Institute on Aging (NIA), NIH, Clinical Research Branch, Baltimore, MD, USA Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 688 EP - 694 PB - Oxford University Press, UK VL - 39 IS - 6 SN - 0002-0729, 0002-0729 KW - Ageing KW - Elderly people KW - Walking KW - Exercise KW - Gait KW - Walking speed KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839573353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Age+and+Ageing&rft.atitle=Age-associated+differences+in+the+gait+pattern+changes+of+older+adults+during+fast-speed+and+fatigue+conditions%3A+results+from+the+Baltimore+longitudinal+study+of+ageing&rft.au=Ko%2C+Seung-uk%3BHausdorff%2C+Jeffrey+M%3BFerrucci%2C+Luigi&rft.aulast=Ko&rft.aufirst=Seung-uk&rft.date=2010-11-01&rft.volume=39&rft.issue=6&rft.spage=688&rft.isbn=&rft.btitle=&rft.title=Age+and+Ageing&rft.issn=00020729&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Walking; Walking speed; Gait; Elderly people; Ageing; Exercise ER - TY - JOUR T1 - Serum Folate, Vitamin B-12, and Homocysteine and Their Association With Depressive Symptoms Among U.S. Adults AN - 839571101; 201100324 AB - Objective: To examine, in a nationally representative sample of U.S. adults, the associations of serum folate, vitamin B-12, and total homocysteine (tHcy) levels with depressive symptoms. Several nutritional and physiological factors have been linked to depression in adults, including low folate and vitamin B-12 and elevated tHcy levels. Methods: Data on U.S. adults (age, 20-85 years; n = 2524) from the National Health and Nutrition Examination Survey during the period 2005 to 2006 were used. Depressive symptoms were measured with the Patient Health Questionnaire (PHQ), and elevated symptoms were defined as a PHQ total score of greater than or equal to 10. Serum folate, vitamin B-12, and tHcy were mainly expressed as tertiles. Multiple ordinary least square (OLS), logistic, and zero-inflated Poisson regression models were conducted in the main analysis. Results: Overall, mean PHQ score was significantly higher among women compared with men. Elevated depressive symptoms (PHQ score of ?10) were inversely associated with folate status, particularly among women (fully adjusted odds ratio [tertiles T3 versus T1] = 0.37; 95% confidence interval, 0.17-0.86), but not significantly related to tHcy or vitamin B-12. No interaction was noted between the three exposures in affecting depressive symptoms. In older adults (?50 years) and both sexes combined, tHcy was positively associated with elevated depressive symptoms (fully adjusted odds ratio [tertiles T2 versus T1] = 3.01; 95% confidence interval, 1.01-9.03), although no significant dose-response relationship was found. Conclusions: Future interventions to improve mental health outcomes among U.S. adults should take into account dietary and other factors that would increase levels of serum folate. Adapted from the source document. JF - Psychosomatic Medicine AU - Beydoun, May A AU - Shroff, Monal R AU - Beydoun, Hind A AU - Zonderman, Alan B AD - NIH Biomedical Research Center, National Institute on Aging, IRP, 251 Bayview Blvd., Suite 100, Room 04B118, Baltimore, MD 21224 Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 862 EP - 873 PB - Lippincott Williams & Wilkins, Philadelphia PA VL - 72 IS - 9 SN - 0033-3174, 0033-3174 KW - depression, folate, vitamin B-12, homocysteine, adults KW - Mental health services KW - Depression KW - Serum KW - Vitamins KW - Health KW - Confidence intervals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839571101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatic+Medicine&rft.atitle=Serum+Folate%2C+Vitamin+B-12%2C+and+Homocysteine+and+Their+Association+With+Depressive+Symptoms+Among+U.S.+Adults&rft.au=Beydoun%2C+May+A%3BShroff%2C+Monal+R%3BBeydoun%2C+Hind+A%3BZonderman%2C+Alan+B&rft.aulast=Beydoun&rft.aufirst=May&rft.date=2010-11-01&rft.volume=72&rft.issue=9&rft.spage=862&rft.isbn=&rft.btitle=&rft.title=Psychosomatic+Medicine&rft.issn=00333174&rft_id=info:doi/10.1097%2FPSY.0b013e3181f61863 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMEAP N1 - SubjectsTermNotLitGenreText - Depression; Vitamins; Serum; Confidence intervals; Health; Mental health services DO - http://dx.doi.org/10.1097/PSY.0b013e3181f61863 ER - TY - JOUR T1 - U.S. Primary Care Physicians' Lung Cancer Screening Beliefs and Recommendations AN - 822497609; 201031986 AB - No high-quality study to date has shown that screening reduces lung cancer mortality, and expert groups do not recommend screening for asymptomatic individuals. Nevertheless, lung cancer screening tests are available in the U.S., and primary care physicians (PCPs) may have a role in recommending them to patients. Purpose This study describes U.S. PCPs' beliefs about and recommendations for lung cancer screening and examines characteristics of PCPs who recommend screening. Methods A nationally representative survey of practicing PCPs was conducted in 2006-2007. Mailed questionnaires were used to assess PCPs' beliefs about lung cancer screening guidelines and the effectiveness of screening tests and to determine whether PCPs would recommend screening for asymptomatic patients. Data were analyzed in 2009. Results Nine hundred sixty-two PCPs completed the survey (absolute response rate=70.6%; cooperation rate=76.8%). One quarter said that major guidelines support lung cancer screening. Two thirds said that low-radiation dose spiral computed tomography (LDCT) screening is very or somewhat effective in reducing lung cancer mortality in current smokers; LDCT was perceived as more effective than chest x-ray or sputum cytology. Responding to vignettes describing asymptomatic patients of varying smoking exposure, 67% of PCPs recommended lung cancer screening for at least one of the vignettes. Most PCPs recommending screening said they would use chest x-ray; up to 26% would use LDCT. In adjusted analyses, PCPs' beliefs and practice style were strongly associated with their lung cancer screening recommendations. Conclusions Many PCPs' lung cancer screening beliefs and recommendations are inconsistent with current evidence and guidelines. Provider education regarding the evidence base and guideline content of lung cancer screening is indicated. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Klabunde, Carrie N AU - Marcus, Pamela M AU - Silvestri, Gerard A AU - Han, Paul K J AU - Richards, Thomas B AU - Yuan, Gigi AU - Marcus, Stephen E AU - Vernon, Sally W AD - Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 411 EP - 420 PB - Elsevier Science, New York NY VL - 39 IS - 5 SN - 0749-3797, 0749-3797 KW - Screening KW - Mortality KW - X-rays KW - Doctors KW - Primary health care KW - Lung cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822497609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=U.S.+Primary+Care+Physicians%27+Lung+Cancer+Screening+Beliefs+and+Recommendations&rft.au=Klabunde%2C+Carrie+N%3BMarcus%2C+Pamela+M%3BSilvestri%2C+Gerard+A%3BHan%2C+Paul+K+J%3BRichards%2C+Thomas+B%3BYuan%2C+Gigi%3BMarcus%2C+Stephen+E%3BVernon%2C+Sally+W&rft.aulast=Klabunde&rft.aufirst=Carrie&rft.date=2010-11-01&rft.volume=39&rft.issue=5&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2010.07.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-12-16 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Screening; Lung cancer; Mortality; X-rays; Primary health care; Doctors DO - http://dx.doi.org/10.1016/j.amepre.2010.07.004 ER - TY - JOUR T1 - Retraining Attitudes and Stereotypes to Affect Motivation and Cognitive Capacity Under Stereotype Threat AN - 822497298; 201031639 AB - In a series of experiments, a retraining paradigm was used to test the effects of attitudes and stereotypes on individuals' motivation and cognitive capacity in stereotype-threatening contexts. Women trained to have a more positive math attitude exhibited increased math motivation (Study 1). This effect was not observed for men but was magnified among women when negative stereotypes were either primed subtly (Study 2) or indirectly reinforced (Study 3). Although attitudes had no effect on working memory capacity, women retrained to associate their gender with being good at math exhibited increased working memory capacity (Studies 3 and 4), which in turn mediated increased math performance (Study 4) in a stereotype-threatening context. Results suggest that although positive attitudes can motivate stigmatized individuals to engage with threatening domains, stereotypes need to be retrained to give them the cognitive capacity critical for success. Implications for interventions to reduce stereotype threat are discussed. [Copyright The American Psychological Association.] JF - Journal of Personality and Social Psychology AU - Forbes, Chad E AU - Schmader, Toni Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 740 EP - 754 PB - American Psychological Association, Washington DC VL - 99 IS - 5 SN - 0022-3514, 0022-3514 KW - stereotype threat attitudes stereotypes motivation working memory KW - Threats KW - Attitudes KW - Motivation KW - Retraining KW - Positive thought KW - Stereotypes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822497298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Personality+and+Social+Psychology&rft.atitle=Retraining+Attitudes+and+Stereotypes+to+Affect+Motivation+and+Cognitive+Capacity+Under+Stereotype+Threat&rft.au=Forbes%2C+Chad+E%3BSchmader%2C+Toni&rft.aulast=Forbes&rft.aufirst=Chad&rft.date=2010-11-01&rft.volume=99&rft.issue=5&rft.spage=740&rft.isbn=&rft.btitle=&rft.title=Journal+of+Personality+and+Social+Psychology&rft.issn=00223514&rft_id=info:doi/10.1037%2Fa0020971 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-12-16 N1 - Last updated - 2016-09-27 N1 - CODEN - JPSPB2 N1 - SubjectsTermNotLitGenreText - Stereotypes; Attitudes; Motivation; Threats; Positive thought; Retraining DO - http://dx.doi.org/10.1037/a0020971 ER - TY - JOUR T1 - Gender differences in the relationship of internalizing and externalizing psychopathology to alcohol dependence: Likelihood, expression and course AN - 822497227; 201031496 AB - Objective To determine whether internalizing and externalizing psychopathology were differentially associated with alcohol dependence in men and women. Methods Four categories of lifetime psychopathology were examined: neither internalizing nor externalizing (NINE), internalizing only (IO), externalizing only (EO) and both internalizing and externalizing (BIE). Multivariate models assessed gender differences in the adjusted associations of these categories with the odds of lifetime alcohol dependence in a representative sample of 43,093 U.S. adults 18 and older and with clinical course and expression in a subsample of 4781 lifetime alcoholics. Results The excess odds of lifetime alcohol dependence associated with IO, EO and BIE were significantly greater for women than men, OR = 2.6, 8.8 and 10.7 versus 1.9, 4.0 and 6.5, respectively. Regardless of gender, the ORs were significantly higher for EO than IO and for BIE than EO. Gender differences in the expression and course of alcoholism were most pronounced for the categories of NINE and IO, with men having greater consumption, dependence severity and treatment but less familial alcoholism. Gender variation in the association of psychopathology with the expression and course of alcoholism was most evident in the BIE category, where the associations were stronger for women. Lifetime externalizing psychopathology was associated with an increased likelihood of treatment utilization, especially among women. Conclusions Findings highlight the need to increase alcoholism screening, prevention and intervention among women with psychopathology, especially externalizing. The greater numbers of internalizing than externalizing alcoholics emphasize the need to treat symptoms of depression and anxiety in alcohol treatment settings. [Copyright Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Dawson, Deborah A AU - Goldstein, Rise B AU - Moss, Howard B AU - Li, Ting-Kai AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA ddawson@mail.nih.gov Y1 - 2010/11/01/ PY - 2010 DA - 2010 Nov 01 SP - 9 EP - 17 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 112 IS - 1-2 SN - 0376-8716, 0376-8716 KW - Alcohol dependence Psychopathology Gender Externalizing Internalizing KW - Internalization KW - Women KW - Alcohol dependence KW - Externalizing behaviour KW - Psychopathology KW - Gender differences KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822497227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Gender+differences+in+the+relationship+of+internalizing+and+externalizing+psychopathology+to+alcohol+dependence%3A+Likelihood%2C+expression+and+course&rft.au=Dawson%2C+Deborah+A%3BGoldstein%2C+Rise+B%3BMoss%2C+Howard+B%3BLi%2C+Ting-Kai%3BGrant%2C+Bridget+F&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2010-11-01&rft.volume=112&rft.issue=1-2&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2010.04.019 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-12-16 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Externalizing behaviour; Psychopathology; Internalization; Gender differences; Alcohol dependence; Women DO - http://dx.doi.org/10.1016/j.drugalcdep.2010.04.019 ER - TY - JOUR T1 - Structural insights into the function of P2X4: an ATP-gated cation channel of neuroendocrine cells. AN - 821198626; 21107680 AB - The P2X4 receptor (P2X4R) is a member of a family of ATP-gated cation channels that are composed of three subunits. Each subunit has two transmembrane (TM) domains linked by a large extracellular loop and intracellularly located N- and C-termini. The receptors are expressed in excitable and non-excitable cells and have been implicated in the modulation of membrane excitability, calcium signaling, neurotransmitter and hormone release, and pain physiology. P2X4Rs activate rapidly and desensitize within the seconds of agonist application, both with the rates dependent on ATP concentrations, and deactivate rapidly and independently of ATP concentration. Disruption of conserved cysteine ectodomain residues affects ATP binding and gating. Several ectodomain residues of P2X4R were identified as critical for ATP binding, including K67, K313, and R295. Ectodomain residues also account for the allosteric regulation of P2X4R; H140 is responsible for copper binding and H286 regulates receptor functions with protons. Ivermectin sensitized receptors, amplified the current amplitude, and slowed receptor deactivation by binding in the TM region. Scanning mutagenesis of TMs revealed the helical topology of both domains, and suggested that receptor function is critically dependent on the conserved Y42 residue. In this brief article, we summarize this study and re-interpret it using a model based on crystallization of the zebrafish P2X4.1 receptor. JF - Cellular and molecular neurobiology AU - Stojilkovic, Stanko S AU - Yan, Zonghe AU - Obsil, Tomas AU - Zemkova, Hana AD - Section on Cellular Signaling, Program in Developmental Neuroscience, NICHD, National Institutes of Health, Bldg. 49, Room 6A-36, 49 Convent Drive, Bethesda, MD 20892-4510, USA. stankos@helix.nih.gov Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 1251 EP - 1258 VL - 30 IS - 8 KW - Receptors, Purinergic P2X4 KW - 0 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Index Medicus KW - Endocytosis KW - Animals KW - Humans KW - Structure-Activity Relationship KW - Ion Channel Gating KW - Neuroendocrine Cells -- metabolism KW - Adenosine Triphosphate -- metabolism KW - Receptors, Purinergic P2X4 -- chemistry KW - Receptors, Purinergic P2X4 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821198626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+and+molecular+neurobiology&rft.atitle=Structural+insights+into+the+function+of+P2X4%3A+an+ATP-gated+cation+channel+of+neuroendocrine+cells.&rft.au=Stojilkovic%2C+Stanko+S%3BYan%2C+Zonghe%3BObsil%2C+Tomas%3BZemkova%2C+Hana&rft.aulast=Stojilkovic&rft.aufirst=Stanko&rft.date=2010-11-01&rft.volume=30&rft.issue=8&rft.spage=1251&rft.isbn=&rft.btitle=&rft.title=Cellular+and+molecular+neurobiology&rft.issn=1573-6830&rft_id=info:doi/10.1007%2Fs10571-010-9568-y LA - 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Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10571-010-9568-y ER - TY - JOUR T1 - Dissecting the Biological Role of Mucin-type O-Glycosylation Using RNA Interference in Drosophila Cell Culture AN - 817608009; 13932404 AB - Mucin type O-glycosylation is a highly conserved form of post-translational modification initiated by the family of enzymes known as the polypeptide a-N-acetylgalactosaminyltransferases (ppGalNAcTs in mammals and PGANTs in Drosophila). To address the cellular functions of the many PGANT family members, RNA interference (RNAi) to each pgant gene was performed in two independent Drosophila cell culture lines. We demonstrate that RNAi to individual pgant genes results in specific reduction in gene expression without affecting the expression of other family members. Cells with reduced expression of individual pgant genes were then examined for changes in viability, morphology, adhesion, and secretion to assess the contribution of each family member to these cellular functions. Here we find that RNAi to pgant3, pgant6, or pgant7 resulted in reduced secretion, further supporting a role for O-glycosylation in proper secretion. Additionally, RNAi to pgant3 or pgant6 resulted in altered Golgi organization, suggesting a role for each in establishing or maintaining proper secretory apparatus structure. Other subcellular effects observed included multinucleated cells seen after RNAi to either pgant2 or pgant35A, suggesting a role for these genes in the completion of cytokinesis. These studies demonstrate the efficient and specific knockdown of pgant gene expression in two Drosophila cell culture systems, resulting in specific morphological and functional effects. Our work provides new information regarding the biological roles of O-glycosylation and illustrates a new platform for interrogating the cellular and subcellular effects of this form of post-translational modification. JF - Journal of Biological Chemistry AU - Zhang, Liping AU - Hagen, Kelly Gten AD - Developmental Glycobiology Unit, NIDCR, National Institutes of Health, Bethesda, Maryland 20892-4370 Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 34477 EP - 34484. PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 285 IS - 45 SN - 0021-9258, 0021-9258 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Golgi apparatus KW - Post-translation KW - Cytokinesis KW - mucin KW - RNA-mediated interference KW - Enzymes KW - Cell culture KW - Glycosylation KW - Drosophila KW - N 14830:RNA KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/817608009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Dissecting+the+Biological+Role+of+Mucin-type+O-Glycosylation+Using+RNA+Interference+in+Drosophila+Cell+Culture&rft.au=Zhang%2C+Liping%3BHagen%2C+Kelly+Gten&rft.aulast=Zhang&rft.aufirst=Liping&rft.date=2010-11-01&rft.volume=285&rft.issue=45&rft.spage=34477&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M110.133561 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Gene expression; Golgi apparatus; Post-translation; Cytokinesis; mucin; Enzymes; RNA-mediated interference; Cell culture; Glycosylation; Drosophila DO - http://dx.doi.org/10.1074/jbc.M110.133561 ER - TY - JOUR T1 - A Mutation within the beta Subunit of Escherichia coli RNA Polymerase Impairs Transcription from Bacteriophage T4 Middle Promoters AN - 815537702; 13821137 AB - During infection of Escherichia coli, bacteriophage T4 usurps the host transcriptional machinery, redirecting it to the expression of early, middle, and late phage genes. Middle genes, whose expression begins about 1 min postinfection, are transcribed both from the extension of early RNA into middle genes and by the activation of T4 middle promoters. Middle-promoter activation requires the T4 transcriptional activator MotA and coactivator AsiA, which are known to interact with 70, the specificity subunit of RNA polymerase. T4 motA amber [motA(Am)] or asiA(Am) phage grows poorly in wild-type E. coli. However, previous work has found that T4 motA(Am)does not grow in the E. coli mutant strain TabG. We show here that the RNA polymerase in TabG contains two mutations within its beta -subunit gene: rpoB(E835K) and rpoB(G1249D). We find that the G1249D mutation is responsible for restricting the growth of either T4 motA(Am)or asiA(Am) and for impairing transcription from MotA/AsiA-activated middle promoters in vivo. With one exception, transcription from tested T4 early promoters is either unaffected or, in some cases, even increases, and there is no significant growth phenotype for the rpoB(E835K G1249D) strain in the absence of T4 infection. In reported structures of thermophilic RNA polymerase, the G1249 residue is located immediately adjacent to a hydrophobic pocket, called the switch 3 loop. This loop is thought to aid in the separation of the RNA from the DNA-RNA hybrid as RNA enters the RNA exit channel. Our results suggest that the presence of MotA and AsiA may impair the function of this loop or that this portion of the beta subunit may influence interactions among MotA, AsiA, and RNA polymerase. JF - Journal of Bacteriology AU - James, Tamara D AU - Cashel, Michael AU - Hinton, Deborah M AD - Gene Expression and Regulation Section, Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0830, dhinton@helix.nih.gov Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 5580 EP - 5587 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 192 IS - 21 SN - 0021-9193, 0021-9193 KW - Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - Phages KW - Promoters KW - DNA-directed RNA polymerase KW - Hybrids KW - Escherichia coli KW - Transcription KW - Hydrophobicity KW - Infection KW - Mutation KW - Amber KW - J 02410:Animal Diseases KW - V 22320:Replication KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815537702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=A+Mutation+within+the+beta+Subunit+of+Escherichia+coli+RNA+Polymerase+Impairs+Transcription+from+Bacteriophage+T4+Middle+Promoters&rft.au=James%2C+Tamara+D%3BCashel%2C+Michael%3BHinton%2C+Deborah+M&rft.aulast=James&rft.aufirst=Tamara&rft.date=2010-11-01&rft.volume=192&rft.issue=21&rft.spage=5580&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.00338-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Number of references - 57 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Phages; Promoters; DNA-directed RNA polymerase; Hybrids; Transcription; Hydrophobicity; Infection; Mutation; Amber; Escherichia coli DO - http://dx.doi.org/10.1128/JB.00338-10 ER - TY - JOUR T1 - Reduction of Immune Activation with Chloroquine Therapy during Chronic HIV Infection AN - 807296053; 13885505 AB - Increased levels of activated T cells are a hallmark of the chronic stage of human immunodeficiency virus (HIV) infection and are highly correlated with HIV disease progression. We evaluated chloroquine (CQ) as a potential therapy to reduce immune activation during HIV infection. We found that the frequency of CD38+ HLA-DR+ CD8 T cells, as well as Ki-67 expression in CD8 and CD4 T cells, was significantly reduced during CQ treatment. Our data indicate that treatment with CQ reduces systemic T-cell immune activation and, thus, that its use may be beneficial for certain groups of HIV-infected individuals. JF - Journal of Virology AU - Murray, Shannon M AU - Down, Carrie M AU - Boulware, David R AU - Stauffer, William M AU - Cavert, Winston P AU - Schacker, Timothy W AU - Brenchley, Jason M AU - Douek, Daniel C AD - National Institutes of Health, National Institute of Allergy and Infectious Diseases, Vaccine Research Center, Human Immunology Section, Bethesda, Maryland, ddouek@mail.nih.gov Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 12082 EP - 12086 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 84 IS - 22 SN - 0022-538X, 0022-538X KW - Immunology Abstracts; Toxicology Abstracts; Virology & AIDS Abstracts KW - Histocompatibility antigen HLA KW - CD4 antigen KW - Data processing KW - Human immunodeficiency virus KW - Chronic infection KW - Lymphocytes T KW - Chloroquine KW - CD8 antigen KW - V 22360:AIDS and HIV KW - X 24310:Pharmaceuticals KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807296053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Reduction+of+Immune+Activation+with+Chloroquine+Therapy+during+Chronic+HIV+Infection&rft.au=Murray%2C+Shannon+M%3BDown%2C+Carrie+M%3BBoulware%2C+David+R%3BStauffer%2C+William+M%3BCavert%2C+Winston+P%3BSchacker%2C+Timothy+W%3BBrenchley%2C+Jason+M%3BDouek%2C+Daniel+C&rft.aulast=Murray&rft.aufirst=Shannon&rft.date=2010-11-01&rft.volume=84&rft.issue=22&rft.spage=12082&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.01466-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Number of references - 22 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; CD4 antigen; Data processing; Chronic infection; Lymphocytes T; Chloroquine; CD8 antigen; Human immunodeficiency virus DO - http://dx.doi.org/10.1128/JVI.01466-10 ER - TY - JOUR T1 - Pseudomonas exotoxin kills Drosophila S2 cells via apoptosis AN - 787167542; 13637593 AB - Pseudomonas exotoxin A (PE) is cytotoxic for eukaryotic cells because it enters cells by receptor-mediated endocytosis, translocates to the cell cytosol and ADP-ribosylates elongation factor 2 (EF2). However, the interaction of this toxin with eukaryotic cells and the mechanism of PE-mediated cell death have not been extensively characterized. The feasibility of carrying out a genome-wide RNAi screen, makes Drosophila melanogaster S2 cells as a good model system to identify essential genes in PE-mediated cytotoxicity, provided a suitable multi-well assay is developed. Here, using the alamarBlueA+ viability assay, we show that Drosophila S2 cells are sensitive to PE at picomolar concentrations and that toxin treatments provoke an increase in caspase activity. This prompted us to use RNAi to characterize the mechanism of cell death. Results indicated that PE-mediated death of S2 cells was dependent on the presence of diphthamide, the post translational modification of EF2, and on the presence of Drice, the terminal caspase of insect cells. RNAi to drice or chemical inhibition of caspase action by z-VAD-fmk protected cells from PE-mediated death. Protection from death by RNAi or z-VAD-fmk did not interfere with toxin delivery to the cytosol leading to inhibition of protein synthesis. Using a convenient alamarBlueA+ assay, our data confirms the cytotoxicity of PE for S2 cells and establishes apoptosis as the mode of PE-mediated death. This confirms the suitability of Drosophila cells as a convenient and simple model to elucidate the role of specific genes and proteins required for PE action. JF - Toxicon AU - Sharma, Ashima K AU - FitzGerald, David AD - Biotherapy Section, Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, HHS, 37 Convent Dr, Room 5124, Bethesda, MD 20892, United States, djpf@helix.nih.gov Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1025 EP - 1034 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 56 IS - 6 SN - 0041-0101, 0041-0101 KW - Microbiology Abstracts B: Bacteriology; Entomology Abstracts; Toxicology Abstracts KW - Pseudomonas exotoxin A KW - Apoptosis KW - Diphthamide KW - RNAi KW - Drice KW - LRP1 KW - ADP KW - PE KW - EF2 KW - Act D KW - CHX KW - dsRNA KW - GFP KW - Dph1 KW - DCP-1 KW - Dronc KW - Hid KW - Bcl-2 KW - z-VAD-fmk KW - DEVD-AFC KW - Translation KW - Protein biosynthesis KW - Data processing KW - Pseudomonas KW - exotoxin A KW - Exotoxins KW - Toxins KW - Elongation KW - Endocytosis KW - Cytotoxicity KW - Insect cells KW - Drosophila melanogaster KW - Cytosol KW - RNA-mediated interference KW - Caspase KW - J 02410:Animal Diseases KW - Z 05330:Reproduction and Development KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/787167542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Pseudomonas+exotoxin+kills+Drosophila+S2+cells+via+apoptosis&rft.au=Sharma%2C+Ashima+K%3BFitzGerald%2C+David&rft.aulast=Sharma&rft.aufirst=Ashima&rft.date=2010-11-01&rft.volume=56&rft.issue=6&rft.spage=1025&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2010.07.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Translation; Apoptosis; Data processing; Protein biosynthesis; exotoxin A; Toxins; Exotoxins; Endocytosis; Elongation; Cytotoxicity; Insect cells; Cytosol; RNA-mediated interference; Caspase; Drosophila melanogaster; Pseudomonas DO - http://dx.doi.org/10.1016/j.toxicon.2010.07.007 ER - TY - JOUR T1 - MORAL FICTIONS AND MEDICAL ETHICS AN - 772270511; 201030475 AB - Conventional medical ethics and the law draw a bright line distinguishing the permitted practice of withdrawing life-sustaining treatment from the forbidden practice of active euthanasia by means of a lethal injection. When clinicians justifiably withdraw life-sustaining treatment, they allow patients to die but do not cause, intend, or have moral responsibility for, the patient's death. In contrast, physicians unjustifiably kill patients whenever they intentionally administer a lethal dose of medication. We argue that the differential moral assessment of these two practices is based on a series of moral fictions - motivated false beliefs that erroneously characterize withdrawing life-sustaining treatment in order to bring accepted end-of-life practices in line with the prevailing moral norm that doctors must never kill patients. When these moral fictions are exposed, it becomes apparent that conventional medical ethics relating to end-of-life decisions is radically mistaken. Adapted from the source document. JF - Bioethics AU - Miller, Franklin G AU - Truog, Robert D AU - Brock, Dan W AD - Department of Bioethics, Clinical Center, National Institutes of Health Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 453 EP - 460 PB - Blackwell, Oxford UK VL - 24 IS - 9 SN - 0269-9702, 0269-9702 KW - fictions end-of-life decisions withdrawing life-sustaining treatment euthanasia KW - Doctors KW - Fiction KW - End of life decisions KW - Life sustaining treatment KW - Medical ethics KW - Moral aspects KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/772270511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioethics&rft.atitle=MORAL+FICTIONS+AND+MEDICAL+ETHICS&rft.au=Miller%2C+Franklin+G%3BTruog%2C+Robert+D%3BBrock%2C+Dan+W&rft.aulast=Miller&rft.aufirst=Franklin&rft.date=2010-11-01&rft.volume=24&rft.issue=9&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=Bioethics&rft.issn=02699702&rft_id=info:doi/10.1111%2Fj.1467-8519.2009.01738.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-11-11 N1 - Last updated - 2016-09-27 N1 - CODEN - BIETEE N1 - SubjectsTermNotLitGenreText - Moral aspects; Life sustaining treatment; Fiction; Medical ethics; End of life decisions; Doctors DO - http://dx.doi.org/10.1111/j.1467-8519.2009.01738.x ER - TY - JOUR T1 - Definition of ubiquitination modulator COP1 as a novel therapeutic target in human hepatocellular carcinoma. AN - 763176782; 20959491 AB - The development of targeted therapeutics for hepatocellular carcinoma (HCC) remains a major challenge. The ubiquitination modulator COP1 regulates p53 activity by ubiquitination and it is frequently overexpressed in human HCC. In this study, we tested the hypothesis that COP1 blockade by short interfering RNA (siRNA)-mediated inhibition could affect the course of HCC progression. The COP1 isoform COP1-1 was selected as the most effective target for siRNAs in terms of growth inhibition and apoptotic induction in several HCC cell lines. Growth inhibition occurred in HCC cells that retained wild-type p53 or expressed mutant p53 (Y220C or R249S), whereas p53-null Hep3B cells were resistant. Microarray expression analysis revealed that the antiproliferative effects of COP1 blockade were driven by a common subset of molecular alterations including a p53-associated functional network. In an orthotopic mouse xenograft model of HCC, systemic delivery of a modified COP1 siRNA by stable nucleic acid-lipid particles suppressed neoplastic growth in liver without unwanted immune responses. Our findings offer a first proof of principle that COP1 can be a promising target for systemic therapy of HCC. ©2010 AACR. JF - Cancer research AU - Lee, Yun-Han AU - Andersen, Jesper B AU - Song, Ho-Taek AU - Judge, Adam D AU - Seo, Daekwan AU - Ishikawa, Tsuyoshi AU - Marquardt, Jens U AU - Kitade, Mitsuteru AU - Durkin, Marian E AU - Raggi, Chiara AU - Woo, Hyun Goo AU - Conner, Elizabeth A AU - Avital, Itzhak AU - Maclachlan, Ian AU - Factor, Valentina M AU - Thorgeirsson, Snorri S AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA. Y1 - 2010/11/01/ PY - 2010 DA - 2010 Nov 01 SP - 8264 EP - 8269 VL - 70 IS - 21 KW - Biomarkers, Tumor KW - 0 KW - RNA, Messenger KW - RNA, Small Interfering KW - TP53 protein, human KW - Tumor Suppressor Protein p53 KW - Ubiquitin KW - RFWD2 protein, human KW - EC 2.3.2.27 KW - Ubiquitin-Protein Ligases KW - Index Medicus KW - Animals KW - Biomarkers, Tumor -- genetics KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Tumor Suppressor Protein p53 -- metabolism KW - Biomarkers, Tumor -- metabolism KW - Gene Expression Profiling KW - Blotting, Western KW - Tumor Cells, Cultured KW - Ubiquitination KW - Transplantation, Heterologous KW - RNA, Small Interfering -- pharmacology KW - Mutation -- genetics KW - Mice, SCID KW - Tumor Suppressor Protein p53 -- genetics KW - Cell Cycle KW - Male KW - Ubiquitin-Protein Ligases -- antagonists & inhibitors KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- prevention & control KW - Carcinoma, Hepatocellular -- metabolism KW - Ubiquitin -- metabolism KW - Liver Neoplasms -- prevention & control KW - Carcinoma, Hepatocellular -- genetics KW - Ubiquitin-Protein Ligases -- genetics KW - Ubiquitin-Protein Ligases -- metabolism KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/763176782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Definition+of+ubiquitination+modulator+COP1+as+a+novel+therapeutic+target+in+human+hepatocellular+carcinoma.&rft.au=Lee%2C+Yun-Han%3BAndersen%2C+Jesper+B%3BSong%2C+Ho-Taek%3BJudge%2C+Adam+D%3BSeo%2C+Daekwan%3BIshikawa%2C+Tsuyoshi%3BMarquardt%2C+Jens+U%3BKitade%2C+Mitsuteru%3BDurkin%2C+Marian+E%3BRaggi%2C+Chiara%3BWoo%2C+Hyun+Goo%3BConner%2C+Elizabeth+A%3BAvital%2C+Itzhak%3BMaclachlan%2C+Ian%3BFactor%2C+Valentina+M%3BThorgeirsson%2C+Snorri+S&rft.aulast=Lee&rft.aufirst=Yun-Han&rft.date=2010-11-01&rft.volume=70&rft.issue=21&rft.spage=8264&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-10-0749 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-21 N1 - Date created - 2010-11-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2002 Apr 11;21(16):2593-604 [11971194] Genes Cells. 2009 Nov;14(11):1209-25 [19849719] Nature. 2004 May 6;429(6987):86-92 [15103385] Hepatology. 2004 Sep;40(3):667-76 [15349906] Carcinogenesis. 1993 May;14(5):987-92 [8389256] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Semin Liver Dis. 2005;25(2):212-25 [15918149] Nat Biotechnol. 2005 Aug;23(8):1002-7 [16041363] Hepatology. 2005 Nov;42(5):1208-36 [16250051] Mol Ther. 2006 Mar;13(3):494-505 [16343994] Nature. 2006 May 4;441(7089):111-4 [16565705] Nat Rev Cancer. 2006 Sep;6(9):674-87 [16929323] Oncogene. 2007 Apr 2;26(15):2202-11 [17401429] Cancer Res. 2008 Jan 15;68(2):434-43 [18199537] N Engl J Med. 2008 Jul 24;359(4):378-90 [18650514] Hepatology. 2008 Oct;48(4):1312-27 [18821591] J Clin Invest. 2009 Mar;119(3):661-73 [19229107] Nat Genet. 2002 Aug;31(4):339-46 [12149612] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-10-0749 ER - TY - JOUR T1 - MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma. AN - 763176373; 20978195 AB - This study determined whether expression levels of a panel of biologically relevant microRNAs can be used as prognostic or predictive biomarkers in patients who participated in the International Adjuvant Lung Cancer Trial (IALT), the largest randomized study conducted to date of adjuvant chemotherapy in patients with radically resected non-small cell lung carcinoma (NSCLC). Expression of miR-21, miR-29b, miR-34a/b/c, miR-155, and let-7a was determined by quantitative real-time PCR in formalin-fixed paraffin-embedded tumor specimens from 639 IALT patients. The prognostic and predictive values of microRNA expression for survival were studied using a Cox model, which included every factor used in the stratified randomization, clinicopathologic prognostic factors, and other factors statistically related to microRNA expression. Investigation of the expression pattern of microRNAs in situ was performed. We also analyzed the association of TP53 mutation status and miR-34a/b/c expression, epidermal growth factor receptor and KRAS mutation status, and miR-21 and Let-7a expression. Finally, the association of p16 and miR-29b expression was assessed. Overall, no significant association was found between any of the tested microRNAs and survival, with the exception of miR-21 for which a deleterious prognostic effect of lowered expression was suggested. Otherwise, no single or combinatorial microRNA expression profile predicted response to adjuvant cisplatin-based chemotherapy. Together, our results indicate that the microRNA expression patterns examined were neither predictive nor prognostic in a large patient cohort with radically resected NSCLC, randomized to receive adjuvant cisplatin-based chemotherapy versus follow-up only. ©2010 AACR. JF - Cancer research AU - Voortman, Johannes AU - Goto, Akiteru AU - Mendiboure, Jean AU - Sohn, Jane J AU - Schetter, Aaron J AU - Saito, Motonobu AU - Dunant, Ariane AU - Pham, Trung C AU - Petrini, Iacopo AU - Lee, Alan AU - Khan, Mohammed A AU - Hainaut, Pierre AU - Pignon, Jean-Pierre AU - Brambilla, Elisabeth AU - Popper, Helmut H AU - Filipits, Martin AU - Harris, Curtis C AU - Giaccone, Giuseppe AD - Medical Oncology Branch and Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892-1906, USA. Y1 - 2010/11/01/ PY - 2010 DA - 2010 Nov 01 SP - 8288 EP - 8298 VL - 70 IS - 21 KW - Antineoplastic Agents KW - 0 KW - Biomarkers, Tumor KW - MIRN155 microRNA, human KW - MIRN21 microRNA, human KW - MIRN29 microRNA, human KW - MIRN34 microRNA, human KW - MicroRNAs KW - RNA, Messenger KW - TP53 protein, human KW - Tumor Suppressor Protein p53 KW - mirnlet7 microRNA, human KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Biomarkers, Tumor -- genetics KW - Neoplasm Invasiveness KW - Paraffin Embedding KW - Combined Modality Therapy KW - Humans KW - Prognosis KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Biomarkers, Tumor -- metabolism KW - In Situ Hybridization KW - Survival Rate KW - Mutation -- genetics KW - Middle Aged KW - Tumor Suppressor Protein p53 -- genetics KW - Antineoplastic Agents -- therapeutic use KW - Chemotherapy, Adjuvant KW - Female KW - Male KW - Cisplatin -- therapeutic use KW - MicroRNAs -- metabolism KW - MicroRNAs -- genetics KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - Lung Neoplasms -- drug therapy KW - Lung Neoplasms -- genetics KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Lung Neoplasms -- pathology KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/763176373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=MicroRNA+expression+and+clinical+outcomes+in+patients+treated+with+adjuvant+chemotherapy+after+complete+resection+of+non-small+cell+lung+carcinoma.&rft.au=Voortman%2C+Johannes%3BGoto%2C+Akiteru%3BMendiboure%2C+Jean%3BSohn%2C+Jane+J%3BSchetter%2C+Aaron+J%3BSaito%2C+Motonobu%3BDunant%2C+Ariane%3BPham%2C+Trung+C%3BPetrini%2C+Iacopo%3BLee%2C+Alan%3BKhan%2C+Mohammed+A%3BHainaut%2C+Pierre%3BPignon%2C+Jean-Pierre%3BBrambilla%2C+Elisabeth%3BPopper%2C+Helmut+H%3BFilipits%2C+Martin%3BHarris%2C+Curtis+C%3BGiaccone%2C+Giuseppe&rft.aulast=Voortman&rft.aufirst=Johannes&rft.date=2010-11-01&rft.volume=70&rft.issue=21&rft.spage=8288&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-10-1348 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-21 N1 - Date created - 2010-11-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2004 Jun 1;64(11):3753-6 [15172979] Nature. 2005 Jun 9;435(7043):834-8 [15944708] N Engl J Med. 2005 Jun 23;352(25):2589-97 [15972865] Cancer Cell. 2006 Mar;9(3):189-98 [16530703] Gastroenterology. 2006 Jun;130(7):2113-29 [16762633] Lancet Oncol. 2006 Sep;7(9):719-27 [16945766] N Engl J Med. 2006 Sep 7;355(10):983-91 [16957145] Mol Cell. 2007 Jun 8;26(5):731-43 [17540598] Mol Cell. 2007 Jun 8;26(5):745-52 [17540599] Nature. 2007 Jun 28;447(7148):1130-4 [17554337] J Clin Oncol. 2007 Jul 1;25(19):2735-40 [17602078] Clin Cancer Res. 2007 Jul 1;13(13):3892-8 [17606722] Cell Cycle. 2007 Jul 1;6(13):1586-93 [17554199] Cancer Res. 2007 Aug 15;67(16):7713-22 [17699775] Cancer Res. 2007 Sep 15;67(18):8433-8 [17823410] Methods. 2008 Jan;44(1):39-46 [18158131] Cancer Cell. 2008 Jan;13(1):48-57 [18167339] JAMA. 2008 Jan 30;299(4):425-36 [18230780] Oncology. 2007;72(5-6):397-402 [18196926] Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3903-8 [18308936] N Engl J Med. 2008 Mar 13;358(11):1118-28 [18337602] Cell Cycle. 2008 Mar 15;7(6):759-64 [18344688] Cancer Res. 2008 May 1;68(9):3193-203 [18451145] Clin Chem. 2008 Oct;54(10):1696-704 [18719201] Cancer Res. 2008 Oct 15;68(20):8535-40 [18922928] RNA. 2008 Nov;14(11):2348-60 [18812439] J Clin Oncol. 2008 Nov 1;26(31):5043-51 [18809614] Biochem Biophys Res Commun. 2008 Dec 5;377(1):114-9 [18834855] J Clin Pathol. 2009 Jan;62(1):84-8 [18755714] Clin Cancer Res. 2009 Jun 15;15(12):3998-4008 [19509158] Blood. 2009 Jun 18;113(25):6411-8 [19211935] Cancer Res. 2009 Jul 15;69(14):5776-83 [19584273] Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12085-90 [19597153] Annu Rev Med. 2009;60:167-79 [19630570] Brain Res. 2009 Aug 25;1286:13-8 [19559015] J Clin Oncol. 2009 Dec 1;27(34):5848-56 [19884536] PLoS One. 2009;4(11):e8003 [19946373] J Clin Oncol. 2010 Jan 1;28(1):35-42 [19933916] N Engl J Med. 2004 Jan 22;350(4):351-60 [14736927] Cancer Res. 2010 Jan 1;70(1):36-45 [20028859] Clin Cancer Res. 2010 Jan 15;16(2):430-41 [20068076] Cancer Res. 2010 Feb 15;70(4):1441-8 [20124485] Blood. 2010 Apr 1;115(13):2630-9 [20086245] PLoS One. 2010;5(5):e10630 [20498843] Lung Cancer. 2010 Jul;69(1):51-3 [19854534] Comment In: Cancer Res. 2011 Aug 1;71(15):5357; author reply 5358-9 [21791642] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-10-1348 ER - TY - JOUR T1 - Blue light induced A2E oxidation in rat eyes--experimental animal model of dry AMD. AN - 762685495; 20922251 AB - Previous studies have shown that short-wavelength blue visible light induces retinal injury and may be a risk factor for age related macular degeneration. A2E is a blue light absorbing retinal chromophore that accumulates with age. Our previous in vitro studies have determined that, although A2E itself has a low phototoxic efficiency, the oxidation products of A2E that are formed in the presence of visible light can contribute to observed retinal pigment epithelial photodamage. The purpose of this study was to investigate the effects of blue light on retinal phototoxicity and its relationship to A2E, oxidized A2E and its isomers. Sprague-Dawley albino rats were dark adapted for 24 h. Control rats remained in the dark while experimental rats were exposed to blue light (λ = 450 nm, 3.1 mW cm(-2)) for 6 h. Isolated retinas were homogenized in Folch extraction mixture and then in chloroform. The dried extracts were reconstituted and divided for determination of organic soluble compound. Esters of fatty acids were determined with GC-MS, A2E and other chromophores using HPLC, and A2E oxidation products with LC-MS. Exposure of rat eyes to blue light did not significantly change the fatty acid composition of the retina. The A2E concentration (normalized to fatty acid content) in blue light exposed animals was found to be lower than the A2E concentration in control rats. The concentrations of all-trans-retinal-ethanolamine adduct and iso-A2E a precursor and an isomer of A2E respectively, were also lower after blue-light exposure than in the retinas of rats housed in the dark. On the other hand, the amount of oxidized forms of A2E was higher in the animals exposed to blue light. We conclude that in the rat eye, blue-light exposure promotes oxidation of A2E and iso-A2E to the products that are toxic to retinal tissue. Although high concentrations of A2E may be cytotoxic to the retina, the phototoxicity associated with blue light damage to the retina is in part a result of the formation of toxic A2E oxides. This effect may partially explain the association between blue light induced retinal injury and macular degeneration. JF - Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology AU - Wielgus, A R AU - Collier, R J AU - Martin, E AU - Lih, F B AU - Tomer, K B AU - Chignell, C F AU - Roberts, J E AD - Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. albert.wielgus@duke.edu Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 1505 EP - 1512 VL - 9 IS - 11 KW - A2-E (N-retinylidene-N-retinylethanolamine) KW - 0 KW - Fatty Acids KW - Pyridinium Compounds KW - Retinoids KW - Cholesterol KW - 97C5T2UQ7J KW - Index Medicus KW - Rats KW - Oxidation-Reduction KW - Animals KW - Rats, Sprague-Dawley KW - Cholesterol -- metabolism KW - Retina -- pathology KW - Retina -- radiation effects KW - Male KW - Fatty Acids -- metabolism KW - Light -- adverse effects KW - Retinoids -- metabolism KW - Macular Degeneration -- pathology KW - Pyridinium Compounds -- metabolism KW - Macular Degeneration -- etiology KW - Disease Models, Animal KW - Pyridinium Compounds -- adverse effects KW - Retinoids -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762685495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemical+%26+photobiological+sciences+%3A+Official+journal+of+the+European+Photochemistry+Association+and+the+European+Society+for+Photobiology&rft.atitle=Blue+light+induced+A2E+oxidation+in+rat+eyes--experimental+animal+model+of+dry+AMD.&rft.au=Wielgus%2C+A+R%3BCollier%2C+R+J%3BMartin%2C+E%3BLih%2C+F+B%3BTomer%2C+K+B%3BChignell%2C+C+F%3BRoberts%2C+J+E&rft.aulast=Wielgus&rft.aufirst=A&rft.date=2010-11-01&rft.volume=9&rft.issue=11&rft.spage=1505&rft.isbn=&rft.btitle=&rft.title=Photochemical+%26+photobiological+sciences+%3A+Official+journal+of+the+European+Photochemistry+Association+and+the+European+Society+for+Photobiology&rft.issn=1474-9092&rft_id=info:doi/10.1039%2Fc0pp00133c LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-03 N1 - Date created - 2010-10-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Photochem Photobiol Sci. 2011 Dec;10(12):1983 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1039/c0pp00133c ER - TY - JOUR T1 - A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. AN - 762478350; 20972438 AB - We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis. JF - Nature genetics AU - Rothman, Nathaniel AU - Garcia-Closas, Montserrat AU - Chatterjee, Nilanjan AU - Malats, Nuria AU - Wu, Xifeng AU - Figueroa, Jonine D AU - Real, Francisco X AU - Van Den Berg, David AU - Matullo, Giuseppe AU - Baris, Dalsu AU - Thun, Michael AU - Kiemeney, Lambertus A AU - Vineis, Paolo AU - De Vivo, Immaculata AU - Albanes, Demetrius AU - Purdue, Mark P AU - Rafnar, Thorunn AU - Hildebrandt, Michelle A T AU - Kiltie, Anne E AU - Cussenot, Olivier AU - Golka, Klaus AU - Kumar, Rajiv AU - Taylor, Jack A AU - Mayordomo, Jose I AU - Jacobs, Kevin B AU - Kogevinas, Manolis AU - Hutchinson, Amy AU - Wang, Zhaoming AU - Fu, Yi-Ping AU - Prokunina-Olsson, Ludmila AU - Burdett, Laurie AU - Yeager, Meredith AU - Wheeler, William AU - Tardón, Adonina AU - Serra, Consol AU - Carrato, Alfredo AU - García-Closas, Reina AU - Lloreta, Josep AU - Johnson, Alison AU - Schwenn, Molly AU - Karagas, Margaret R AU - Schned, Alan AU - Andriole, Gerald AU - Grubb, Robert AU - Black, Amanda AU - Jacobs, Eric J AU - Diver, W Ryan AU - Gapstur, Susan M AU - Weinstein, Stephanie J AU - Virtamo, Jarmo AU - Cortessis, Victoria K AU - Gago-Dominguez, Manuela AU - Pike, Malcolm C AU - Stern, Mariana C AU - Yuan, Jian-Min AU - Hunter, David J AU - McGrath, Monica AU - Dinney, Colin P AU - Czerniak, Bogdan AU - Chen, Meng AU - Yang, Hushan AU - Vermeulen, Sita H AU - Aben, Katja K AU - Witjes, J Alfred AU - Makkinje, Remco R AU - Sulem, Patrick AU - Besenbacher, Soren AU - Stefansson, Kari AU - Riboli, Elio AU - Brennan, Paul AU - Panico, Salvatore AU - Navarro, Carmen AU - Allen, Naomi E AU - Bueno-de-Mesquita, H Bas AU - Trichopoulos, Dimitrios AU - Caporaso, Neil AU - Landi, Maria Teresa AU - Canzian, Federico AU - Ljungberg, Borje AU - Tjonneland, Anne AU - Clavel-Chapelon, Francoise AU - Bishop, David T AU - Teo, Mark T W AU - Knowles, Margaret A AU - Guarrera, Simonetta AU - Polidoro, Silvia AU - Ricceri, Fulvio AU - Sacerdote, Carlotta AU - Allione, Alessandra AU - Cancel-Tassin, Geraldine AU - Selinski, Silvia AU - Hengstler, Jan G AU - Dietrich, Holger AU - Fletcher, Tony AU - Rudnai, Peter AU - Gurzau, Eugen AU - Koppova, Kvetoslava AU - Bolick, Sophia C E AU - Godfrey, Ashley AU - Xu, Zongli AU - Sanz-Velez, José I AU - D García-Prats, María AU - Sanchez, Manuel AU - Valdivia, Gabriel AU - Porru, Stefano AU - Benhamou, Simone AU - Hoover, Robert N AU - Fraumeni, Joseph F AU - Silverman, Debra T AU - Chanock, Stephen J AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 978 EP - 984 VL - 42 IS - 11 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - NAT2 protein, human KW - Index Medicus KW - Neoplasm Staging KW - Sex Characteristics KW - Humans KW - Smoking -- adverse effects KW - Europe -- epidemiology KW - Chromosome Mapping -- methods KW - Arylamine N-Acetyltransferase -- metabolism KW - Risk Assessment KW - Risk Factors KW - Family KW - Incidence KW - Spain -- epidemiology KW - United States -- epidemiology KW - Female KW - Male KW - Arylamine N-Acetyltransferase -- genetics KW - Polymorphism, Single Nucleotide KW - Urinary Bladder Neoplasms -- pathology KW - Urinary Bladder Neoplasms -- epidemiology KW - Urinary Bladder Neoplasms -- genetics KW - Chromosomes, Human, Pair 22 -- genetics KW - Chromosomes, Human, Pair 18 -- genetics KW - Genetic Predisposition to Disease KW - Chromosomes, Human, Pair 2 -- genetics KW - Genome-Wide Association Study UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762478350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+genetics&rft.atitle=A+multi-stage+genome-wide+association+study+of+bladder+cancer+identifies+multiple+susceptibility+loci.&rft.au=Rothman%2C+Nathaniel%3BGarcia-Closas%2C+Montserrat%3BChatterjee%2C+Nilanjan%3BMalats%2C+Nuria%3BWu%2C+Xifeng%3BFigueroa%2C+Jonine+D%3BReal%2C+Francisco+X%3BVan+Den+Berg%2C+David%3BMatullo%2C+Giuseppe%3BBaris%2C+Dalsu%3BThun%2C+Michael%3BKiemeney%2C+Lambertus+A%3BVineis%2C+Paolo%3BDe+Vivo%2C+Immaculata%3BAlbanes%2C+Demetrius%3BPurdue%2C+Mark+P%3BRafnar%2C+Thorunn%3BHildebrandt%2C+Michelle+A+T%3BKiltie%2C+Anne+E%3BCussenot%2C+Olivier%3BGolka%2C+Klaus%3BKumar%2C+Rajiv%3BTaylor%2C+Jack+A%3BMayordomo%2C+Jose+I%3BJacobs%2C+Kevin+B%3BKogevinas%2C+Manolis%3BHutchinson%2C+Amy%3BWang%2C+Zhaoming%3BFu%2C+Yi-Ping%3BProkunina-Olsson%2C+Ludmila%3BBurdett%2C+Laurie%3BYeager%2C+Meredith%3BWheeler%2C+William%3BTard%C3%B3n%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarc%C3%ADa-Closas%2C+Reina%3BLloreta%2C+Josep%3BJohnson%2C+Alison%3BSchwenn%2C+Molly%3BKaragas%2C+Margaret+R%3BSchned%2C+Alan%3BAndriole%2C+Gerald%3BGrubb%2C+Robert%3BBlack%2C+Amanda%3BJacobs%2C+Eric+J%3BDiver%2C+W+Ryan%3BGapstur%2C+Susan+M%3BWeinstein%2C+Stephanie+J%3BVirtamo%2C+Jarmo%3BCortessis%2C+Victoria+K%3BGago-Dominguez%2C+Manuela%3BPike%2C+Malcolm+C%3BStern%2C+Mariana+C%3BYuan%2C+Jian-Min%3BHunter%2C+David+J%3BMcGrath%2C+Monica%3BDinney%2C+Colin+P%3BCzerniak%2C+Bogdan%3BChen%2C+Meng%3BYang%2C+Hushan%3BVermeulen%2C+Sita+H%3BAben%2C+Katja+K%3BWitjes%2C+J+Alfred%3BMakkinje%2C+Remco+R%3BSulem%2C+Patrick%3BBesenbacher%2C+Soren%3BStefansson%2C+Kari%3BRiboli%2C+Elio%3BBrennan%2C+Paul%3BPanico%2C+Salvatore%3BNavarro%2C+Carmen%3BAllen%2C+Naomi+E%3BBueno-de-Mesquita%2C+H+Bas%3BTrichopoulos%2C+Dimitrios%3BCaporaso%2C+Neil%3BLandi%2C+Maria+Teresa%3BCanzian%2C+Federico%3BLjungberg%2C+Borje%3BTjonneland%2C+Anne%3BClavel-Chapelon%2C+Francoise%3BBishop%2C+David+T%3BTeo%2C+Mark+T+W%3BKnowles%2C+Margaret+A%3BGuarrera%2C+Simonetta%3BPolidoro%2C+Silvia%3BRicceri%2C+Fulvio%3BSacerdote%2C+Carlotta%3BAllione%2C+Alessandra%3BCancel-Tassin%2C+Geraldine%3BSelinski%2C+Silvia%3BHengstler%2C+Jan+G%3BDietrich%2C+Holger%3BFletcher%2C+Tony%3BRudnai%2C+Peter%3BGurzau%2C+Eugen%3BKoppova%2C+Kvetoslava%3BBolick%2C+Sophia+C+E%3BGodfrey%2C+Ashley%3BXu%2C+Zongli%3BSanz-Velez%2C+Jos%C3%A9+I%3BD+Garc%C3%ADa-Prats%2C+Mar%C3%ADa%3BSanchez%2C+Manuel%3BValdivia%2C+Gabriel%3BPorru%2C+Stefano%3BBenhamou%2C+Simone%3BHoover%2C+Robert+N%3BFraumeni%2C+Joseph+F%3BSilverman%2C+Debra+T%3BChanock%2C+Stephen+J&rft.aulast=Rothman&rft.aufirst=Nathaniel&rft.date=2010-11-01&rft.volume=42&rft.issue=11&rft.spage=978&rft.isbn=&rft.btitle=&rft.title=Nature+genetics&rft.issn=1546-1718&rft_id=info:doi/10.1038%2Fng.687 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-16 N1 - Date created - 2010-10-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Blood. 2008 May 1;111(9):4446-55 [18239083] Nature. 2007 Oct 18;449(7164):851-61 [17943122] Arch Toxicol. 2008 Jul;82(7):415-33 [18491077] PLoS One. 2008;3(7):e2551 [18596976] Genome Biol. 2008;9(6):229 [18598372] Biostatistics. 2008 Oct;9(4):593-600 [18441336] Hum Mol Genet. 2008 Oct 15;17(R2):R122-8 [18852200] Nat Genet. 2008 Nov;40(11):1307-12 [18794855] Nat Genet. 2009 Feb;41(2):221-7 [19151717] Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1187-92 [19147845] Nat Genet. 2009 Aug;41(8):909-14 [19578363] Nat Genet. 2009 Aug;41(8):899-904 [19578367] Nat Genet. 2009 Sep;41(9):991-5 [19648920] Nat Genet. 2009 Oct;41(10):1116-21 [19767753] Nat Genet. 2009 Oct;41(10):1055-7 [19767755] Am J Hum Genet. 2009 Nov;85(5):679-91 [19836008] Nat Genet. 2010 Feb;42(2):132-6 [20062064] J Biochem. 2010 Mar;147(3):353-60 [19880377] Nat Genet. 2010 Mar;42(3):224-8 [20101243] Nat Genet. 2010 May;42(5):415-9 [20348956] Nat Genet. 2010 Jul;42(7):570-5 [20562874] Genetics. 2000 Jun;155(2):945-59 [10835412] Am J Pathol. 2000 Sep;157(3):787-94 [10980118] Int J Cancer. 2001 Jan 1;91(1):141-3 [11149414] Cancer Res. 2000 Dec 15;60(24):6921-6 [11156391] Nat Rev Cancer. 2001 Dec;1(3):222-31 [11902577] Hum Hered. 2002;54(2):99-110 [12566741] Nat Genet. 2004 Apr;36(4):388-93 [15052270] Genetics. 2004 Aug;167(4):2067-81 [15342541] Environ Health Perspect. 1979 Apr;29:71-9 [510245] Int J Cancer. 1985 Jun 15;35(6):703-6 [4008097] J Natl Cancer Inst. 1993 Jul 21;85(14):1159-64 [8320745] Cancer Res. 1997 Jul 15;57(14):2979-85 [9230212] Mol Pharmacol. 1998 Oct;54(4):647-54 [9765507] Am J Hum Genet. 2005 May;76(5):887-93 [15789306] Lancet. 2005 Aug 20-26;366(9486):649-59 [16112301] Oncogene. 2006 Mar 13;25(11):1649-58 [16550165] Eur J Cancer. 2006 Jul;42(10):1428-33 [16737809] Nat Genet. 2006 Aug;38(8):904-9 [16862161] Bioinformatics. 2006 Dec 15;22(24):3061-6 [17060358] N Engl J Med. 2007 Mar 29;356(13):1317-26 [17392301] Nat Genet. 2007 May;39(5):645-9 [17401363] Proc Natl Acad Sci U S A. 2007 May 1;104(18):7552-7 [17460043] Int J Epidemiol. 2007 Feb;36(1):23-8 [17510073] Nature. 2007 Jun 7;447(7145):661-78 [17554300] Nature. 2007 Jun 28;447(7148):1087-93 [17529967] Nat Genet. 2007 Aug;39(8):989-94 [17618283] Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1595-600 [17684133] PLoS Genet. 2006 Dec;2(12):e190 [17194218] Nat Genet. 2008 May;40(5):623-30 [18372905] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/ng.687 ER - TY - JOUR T1 - Hierarchical clustering of human papilloma virus genotype patterns in the ASCUS-LSIL triage study. AN - 762282647; 20959485 AB - Anogenital cancers are associated with ∼13 carcinogenic human papilloma virus (HPV) types in a broader group that cause cervical intraepithelial neoplasia (CIN). Multiple concurrent cervical HPV infections are common, which complicates the attribution of HPV types to different grades of CIN. Here we report the analysis of HPV genotype patterns in the atypical squamous cells of undetermined significance-low-grade squamous intraepithelial lesion triage study with the use of unsupervised hierarchical clustering. Women who underwent colposcopy at baseline (n = 2,780) were grouped into 20 disease categories based on histology and cytology. Disease groups and HPV genotypes were clustered with the use of complete linkage. Risk of 2-year cumulative CIN3+, viral load, colposcopic impression, and age were compared between disease groups and major clusters. Hierarchical clustering yielded four major disease clusters: cluster 1 included all CIN3 histology with abnormal cytology; cluster 2 included CIN3 histology with normal cytology and combinations with either CIN2 or high-grade squamous intraepithelial lesion cytology; cluster 3 included older women with normal or low-grade histology/cytology and low viral load; and cluster 4 included younger women with low-grade histology/cytology, multiple infections, and the highest viral load. Three major groups of HPV genotypes were identified: group 1 included only HPV16; group 2 included nine carcinogenic types, plus noncarcinogenic HPV53 and HPV66; and group 3 included noncarcinogenic types, plus carcinogenic HPV33 and HPV45. Clustering results suggested that colposcopy missed a prevalent precancer in many women with no biopsy/normal histology and high-grade squamous intraepithelial lesion. This result was confirmed by an elevated 2-year risk of CIN3+ in these groups. Our novel approach to study multiple genotype infections in cervical disease with the use of unsupervised hierarchical clustering can address complex genotype distributions on a population level. ©2010 AACR. JF - Cancer research AU - Wentzensen, Nicolas AU - Wilson, Lauren E AU - Wheeler, Cosette M AU - Carreon, Joseph D AU - Gravitt, Patti E AU - Schiffman, Mark AU - Castle, Philip E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852-7234, USA. wentzenn@mail.nih.gov Y1 - 2010/11/01/ PY - 2010 DA - 2010 Nov 01 SP - 8578 EP - 8586 VL - 70 IS - 21 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Viral Load KW - Genotype KW - Young Adult KW - Risk Factors KW - Humans KW - Adult KW - Vaginal Smears KW - DNA, Viral -- genetics KW - Cluster Analysis KW - Female KW - Colposcopy KW - Uterine Cervical Dysplasia -- pathology KW - Papillomavirus Infections -- pathology KW - Cervical Intraepithelial Neoplasia -- pathology KW - Papillomaviridae -- classification KW - Papillomavirus Infections -- virology KW - Cervical Intraepithelial Neoplasia -- virology KW - Papillomaviridae -- genetics KW - Uterine Cervical Dysplasia -- virology KW - Uterine Cervical Neoplasms -- pathology KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762282647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Hierarchical+clustering+of+human+papilloma+virus+genotype+patterns+in+the+ASCUS-LSIL+triage+study.&rft.au=Wentzensen%2C+Nicolas%3BWilson%2C+Lauren+E%3BWheeler%2C+Cosette+M%3BCarreon%2C+Joseph+D%3BGravitt%2C+Patti+E%3BSchiffman%2C+Mark%3BCastle%2C+Philip+E&rft.aulast=Wentzensen&rft.aufirst=Nicolas&rft.date=2010-11-01&rft.volume=70&rft.issue=21&rft.spage=8578&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-10-1188 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-21 N1 - Date created - 2010-11-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 2003 Feb 6;348(6):489-90 [12571255] JAMA. 2001 Mar 21;285(11):1500-5 [11255427] Am J Obstet Gynecol. 2004 Aug;191(2):430-4 [15343217] J Clin Microbiol. 1998 Oct;36(10):3020-7 [9738060] Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14863-8 [9843981] Virology. 2005 Jun 20;337(1):76-84 [15914222] Cancer Res. 2006 Jan 15;66(2):1218-24 [16424061] Obstet Gynecol. 2006 Aug;108(2):264-72 [16880294] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] Lancet. 2007 Sep 8;370(9590):890-907 [17826171] Int J Gynecol Pathol. 2007 Oct;26(4):441-6 [17885496] J Clin Microbiol. 2008 Jan;46(1):109-17 [17989194] Int J Cancer. 2008 Oct 15;123(8):1864-70 [18661520] Int J Cancer. 2009 Feb 15;124(4):964-9 [19030188] Lancet Oncol. 2009 Apr;10(4):321-2 [19350698] Int J Cancer. 2009 Nov 1;125(9):2151-8 [19585494] Acta Cytol. 2000 Sep-Oct;44(5):726-42 [11015972] Bioinformatics. 2004 Jun 12;20(9):1453-4 [14871861] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-10-1188 ER - TY - JOUR T1 - Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients. AN - 762274839; 20978357 AB - Inducible nitric oxide synthase (NOS2) is involved in wound healing, angiogenesis, and carcinogenesis. NOS2 upregulation and increased nitric oxide (NO) production affect the redox state of cells and can induce protein, lipid, and DNA modifications. To investigate whether NOS2 levels influence survival of breast cancer patients, we examined NOS2 expression and its association with tumor markers and survival in 248 breast tumors. In multivariable survival analysis, increased NOS2 predicted inferior survival in women with estrogen receptor α-negative (ER-negative) tumors. Microdissected tumor epithelium from ER-negative tumors with high NOS2 had increased IL-8 and a gene expression signature characteristic of basal-like breast cancer with poor prognosis. In cell culture, NO only induced selected signature genes in ER-negative breast cancer cells. ER transgene expression in ER-negative cells inhibited NO-induced upregulation of the stem cell marker CD44 and other proteins encoded by signature genes, but not of IL-8. Exposure to NO also enhanced cell motility and invasion of ER-negative cells. Last, pathway analysis linked the tumor NOS2 gene signature to c-Myc activation. Thus, NOS2 is associated with a basal-like transcription pattern and poor survival of ER-negative patients. JF - The Journal of clinical investigation AU - Glynn, Sharon A AU - Boersma, Brenda J AU - Dorsey, Tiffany H AU - Yi, Ming AU - Yfantis, Harris G AU - Ridnour, Lisa A AU - Martin, Damali N AU - Switzer, Christopher H AU - Hudson, Robert S AU - Wink, David A AU - Lee, Dong H AU - Stephens, Robert M AU - Ambs, Stefan AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 3843 EP - 3854 VL - 120 IS - 11 KW - Biomarkers, Tumor KW - 0 KW - Interleukin-8 KW - Receptors, Estrogen KW - Nitric Oxide KW - 31C4KY9ESH KW - NOS2 protein, human KW - EC 1.14.13.39 KW - Nitric Oxide Synthase Type II KW - Abridged Index Medicus KW - Index Medicus KW - Cell Movement KW - Biomarkers, Tumor -- metabolism KW - Gene Expression Profiling KW - Animals KW - Survival Rate KW - Humans KW - Prognosis KW - Molecular Sequence Data KW - Nitric Oxide -- metabolism KW - Interleukin-8 -- genetics KW - Cell Line, Tumor KW - Interleukin-8 -- metabolism KW - Female KW - Survival Analysis KW - Breast Neoplasms -- pathology KW - Breast Neoplasms -- diagnosis KW - Nitric Oxide Synthase Type II -- metabolism KW - Receptors, Estrogen -- metabolism KW - Breast Neoplasms -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762274839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Increased+NOS2+predicts+poor+survival+in+estrogen+receptor-negative+breast+cancer+patients.&rft.au=Glynn%2C+Sharon+A%3BBoersma%2C+Brenda+J%3BDorsey%2C+Tiffany+H%3BYi%2C+Ming%3BYfantis%2C+Harris+G%3BRidnour%2C+Lisa+A%3BMartin%2C+Damali+N%3BSwitzer%2C+Christopher+H%3BHudson%2C+Robert+S%3BWink%2C+David+A%3BLee%2C+Dong+H%3BStephens%2C+Robert+M%3BAmbs%2C+Stefan&rft.aulast=Glynn&rft.aufirst=Sharon&rft.date=2010-11-01&rft.volume=120&rft.issue=11&rft.spage=3843&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=1558-8238&rft_id=info:doi/10.1172%2FJCI42059 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-07 N1 - Date created - 2010-11-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pol J Pathol. 2007;58(3):183-8 [18074863] Int J Cancer. 2008 Mar 1;122(5):1089-94 [17960621] Head Neck. 2008 Feb;30(2):208-14 [17657783] Breast Cancer Res. 2007;9(4):212 [17705880] Int J Cancer. 2008 Mar 15;122(6):1324-32 [17999412] BMC Cancer. 2008;8:9 [18199328] Nat Genet. 2008 May;40(5):499-507 [18443585] J Biol Chem. 2008 Jun 20;283(25):17635-51 [18441325] Mol Cancer Res. 2008 Jun;6(6):996-1002 [18567803] Breast Cancer Res. 2008;10(3):R53 [18559090] J Endocrinol. 2008 Nov;199(2):267-73 [18753331] Cancer Res. 2009 Feb 15;69(4):1302-13 [19190339] Cancer Res. 2009 Jun 1;69(11):4878-84 [19487298] J Immunol. 2009 Dec 1;183(11):6998-7005 [19890039] Breast Cancer Res Treat. 2010 Jul;122(2):315-24 [19795205] J Leukoc Biol. 2004 Jul;76(1):278-87 [15178710] Clin Cancer Res. 2004 Aug 15;10(16):5367-74 [15328174] Am J Physiol Lung Cell Mol Physiol. 2004 Oct;287(4):L764-73 [15169673] Genome Biol. 2004;5(10):R80 [15461798] Eur J Surg Oncol. 1986 Sep;12(3):273-6 [3758366] N Engl J Med. 1991 Jan 3;324(1):1-8 [1701519] Histopathology. 1991 Nov;19(5):403-10 [1757079] Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):9813-7 [8234317] Cell. 1994 Sep 23;78(6):915-8 [7522969] J Clin Invest. 1994 Nov;94(5):2036-44 [7525653] Proc Natl Acad Sci U S A. 1995 May 9;92(10):4392-6 [7538668] Br J Cancer. 1995 Jul;72(1):41-4 [7541238] Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1054-9 [8577713] Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2442-7 [8637893] Cancer Res. 1996 Oct 15;56(20):4625-9 [8840975] Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15102-7 [8986771] FASEB J. 1997 May;11(6):443-8 [9194524] Cancer Res. 1997 Aug 15;57(16):3365-9 [9269997] Cancer Res. 1998 Jan 15;58(2):334-41 [9443414] J Clin Invest. 1998 Mar 1;101(5):967-71 [9486966] Carcinogenesis. 1998 May;19(5):711-21 [9635855] Free Radic Biol Med. 1998 Sep;25(4-5):434-56 [9741580] Nat Med. 1998 Dec;4(12):1371-6 [9846573] Int J Mol Med. 1998 Dec;2(6):715-9 [9850741] J Natl Cancer Inst. 1999 Jan 6;91(1):86-8 [9890175] Clin Cancer Res. 2004 Nov 1;10(21):7157-62 [15534087] World J Gastroenterol. 2005 Jan 7;11(1):46-50 [15609395] Eur J Cancer. 2005 Jan;41(2):265-71 [15661552] Cancer Cell. 2005 Jun;7(6):575-89 [15950906] Cancer Res. 2005 Jul 1;65(13):5506-11 [15994920] Virchows Arch. 2005 Jul;447(1):24-30 [15947943] Virchows Arch. 2005 Oct;447(4):688-94 [16012853] Mod Pathol. 2006 Feb;19(2):264-71 [16341146] Br J Cancer. 2006 Jan 30;94(2):184-8 [16434982] CA Cancer J Clin. 2006 Jan-Feb;56(1):37-47; quiz 50-1 [16449185] Breast Cancer Res. 2005;7(6):R953-64 [16280042] Oncogene. 2006 Apr 6;25(15):2273-84 [16288205] Int J Cancer. 2006 Aug 15;119(4):861-6 [16557582] J Natl Cancer Inst. 2006 Jul 5;98(13):911-9 [16818855] J Surg Oncol. 2006 Sep 1;94(3):226-33 [16900533] World J Gastroenterol. 2006 Aug 7;12(29):4660-4 [16937436] J Natl Cancer Inst. 2006 Dec 20;98(24):1777-85 [17179479] Int J Cancer. 2007 Feb 15;120(4):796-805 [17096325] Cancer Res. 2007 Jan 1;67(1):289-99 [17210710] Breast Cancer Res. 2006;8(5):R59 [17062128] Virchows Arch. 2007 Jan;450(1):73-80 [17123107] Breast Cancer Res. 2007;9(1):R6 [17239243] Breast Cancer Res Treat. 2010 Aug;122(3):795-801 [20571867] Clin Cancer Res. 2000 Jun;6(6):2408-16 [10873093] Cancer Res. 2000 Nov 1;60(21):5977-83 [11085516] Clin Cancer Res. 2000 Dec;6(12):4739-44 [11156228] J Interferon Cytokine Res. 2001 Jul;21(7):529-37 [11506748] Int Immunopharmacol. 2001 Aug;1(8):1421-41 [11515809] Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869-74 [11553815] Cancer Res. 2002 Feb 1;62(3):632-5 [11830510] Oncology. 2003;64(1):90-6 [12457036] Nature. 2002 Dec 19-26;420(6917):860-7 [12490959] Oncogene. 2003 Jan 16;22(2):256-65 [12527894] Biochem Biophys Res Commun. 2003 Apr 18;303(4):1129-34 [12684053] Int J Cancer. 2003 Aug 10;106(1):1-7 [12794750] Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5 [12883005] Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13988-93 [14623984] Breast Cancer Res. 2007;9(1):R15 [17261184] Int J Cancer. 2007 Nov 1;121(9):1949-57 [17621625] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1172/JCI42059 ER - TY - JOUR T1 - Evaluation of the effect of pyrimethamine, an anti-malarial drug, on HIV-1 replication AN - 762272298; 13820159 AB - Co-infection of human immunodeficiency virus (HIV) with malaria is one of the pandemic problems in Africa and parts of Asia. Here we investigated the impact of pyrimethamine (PYR) and two other clinical anti-malarial drugs (chloroquine [CQ] or artemisinin [ART]) on HIV-1 replication. Peripheral blood mononuclear cells (PBMCs) or MT-2 cells were infected with HIVNL4.3 strain and treated with different concentrations of the anti-malarial drugs. HIV-1 replication was measured using p24 ELISA. We show that 10I14M CQ and ART inhibited HIV-1 replication by 76% and 60% in PBMCs, respectively, but not in MT-2 cells. In contrast, 10I14M PYR enhanced HIV-1 replication in MT-2 cells by >10-fold. A series of molecular mechanism studies revealed that PYR increased intracellular HIV gag proteins without affecting the promoter or the reverse transcriptase activity. The effect of PYR was independent of HTLV-1 produced by MT-2 cells. Of interest, PYR treatment led to S-phase accumulation and increased AZT and d4T antiviral activity by 4-fold. Taken together, we show that PYR significantly enhances HIV-1 replication by affecting the cellular machinery. Our results could be relevant for the management of malaria and HIV particularly in regions where HIV-1 and malaria epidemics overlap. JF - Virus Research AU - Oguariri, Raphael M AU - Adelsberger, Joseph W AU - Baseler, Michael W AU - Imamichi, Tomozumi AD - Laboratory of Human Retrovirology, Science Applications International Corporation-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA, oguaririr@mail.nih.gov Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 269 EP - 276 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 153 IS - 2 SN - 0168-1702, 0168-1702 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; Virology & AIDS Abstracts KW - Pyrimethamine KW - DHFR KW - Anti-malaria KW - S-phase KW - HIV-1 replication KW - Nucleoside analog KW - Molecular modelling KW - Human diseases KW - Human T-lymphotropic virus 1 KW - Disease control KW - Zidovudine KW - Malaria KW - Promoters KW - pandemics KW - Peripheral blood mononuclear cells KW - Antiviral agents KW - Human immunodeficiency virus 1 KW - RNA-directed DNA polymerase KW - ELISA KW - Asia KW - Drugs KW - Enzyme-linked immunosorbent assay KW - Epidemics KW - Replication KW - antiretroviral therapy KW - Chloroquine KW - Antiviral activity KW - Gag protein KW - Africa KW - artemisinin KW - K 03340:Effects of Physical & Chemical Factors KW - V 22360:AIDS and HIV KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762272298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virus+Research&rft.atitle=Evaluation+of+the+effect+of+pyrimethamine%2C+an+anti-malarial+drug%2C+on+HIV-1+replication&rft.au=Oguariri%2C+Raphael+M%3BAdelsberger%2C+Joseph+W%3BBaseler%2C+Michael+W%3BImamichi%2C+Tomozumi&rft.aulast=Oguariri&rft.aufirst=Raphael&rft.date=2010-11-01&rft.volume=153&rft.issue=2&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Virus+Research&rft.issn=01681702&rft_id=info:doi/10.1016%2Fj.virusres.2010.08.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Promoters; Human diseases; Epidemics; Antiviral agents; Replication; Disease control; ELISA; Malaria; Drugs; Pyrimethamine; Molecular modelling; Enzyme-linked immunosorbent assay; antiretroviral therapy; Zidovudine; Chloroquine; Antiviral activity; Gag protein; Peripheral blood mononuclear cells; pandemics; RNA-directed DNA polymerase; artemisinin; Human immunodeficiency virus 1; Human T-lymphotropic virus 1; Africa; Asia DO - http://dx.doi.org/10.1016/j.virusres.2010.08.018 ER - TY - JOUR T1 - Prime time for G-protein-coupled receptor heteromers as therapeutic targets for CNS disorders: the dopamine D₁-D₃ receptor heteromer. AN - 762030155; 20632968 AB - A number of G-protein-coupled receptors (GPCRs) are currently under consideration as potential therapeutic targets for drugs acting in the central nervous system (CNS). Attempts to discover new medications have operated under the assumption that GPCRs are monomers and that a specific drug activates one single receptor coupled to one single signal transduction mechanism. In the neuronal membrane, GPCRs are now known to be arranged into homo- and hetero-oligomers; drugs acting on a single receptor within a specific heteromer context are thought to induce a particular downstream signaling. However, there is recent evidence showing that heteromer-tailored drugs can be designed that display different affinities for a given receptor depending on the receptor partners contained within the heteromer. It can therefore be predicted that customized drugs targeting a specific receptor heteromer in the CNS might improve safety and efficacy for their therapeutic targets. Finally, it will be important to identify receptor heteromers that are involved in the pathogenesis of diseases, such as the recently discovered dopamine D₁-D₃ receptor heteromer, which might play a key role in L-DOPA-induced dyskinesia in Parkinson's disease. JF - CNS & neurological disorders drug targets AU - Ferré, Sergi AU - Lluis, Carmen AU - Lanciego, José Luis AU - Franco, Rafael AD - National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA. sferre@intra.nida.nih.gov Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 596 EP - 600 VL - 9 IS - 5 KW - Receptors, Dopamine KW - 0 KW - Receptors, G-Protein-Coupled KW - Index Medicus KW - Animals KW - Humans KW - Brain -- drug effects KW - Brain -- metabolism KW - Models, Neurological KW - Protein Multimerization KW - Drug Design KW - Receptors, Dopamine -- drug effects KW - Receptors, G-Protein-Coupled -- drug effects KW - Receptors, G-Protein-Coupled -- metabolism KW - Drug Delivery Systems -- methods KW - Central Nervous System Diseases -- drug therapy KW - Central Nervous System Diseases -- metabolism KW - Receptors, Dopamine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762030155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=CNS+%26+neurological+disorders+drug+targets&rft.atitle=Prime+time+for+G-protein-coupled+receptor+heteromers+as+therapeutic+targets+for+CNS+disorders%3A+the+dopamine+D%E2%82%81-D%E2%82%83+receptor+heteromer.&rft.au=Ferr%C3%A9%2C+Sergi%3BLluis%2C+Carmen%3BLanciego%2C+Jos%C3%A9+Luis%3BFranco%2C+Rafael&rft.aulast=Ferr%C3%A9&rft.aufirst=Sergi&rft.date=2010-11-01&rft.volume=9&rft.issue=5&rft.spage=596&rft.isbn=&rft.btitle=&rft.title=CNS+%26+neurological+disorders+drug+targets&rft.issn=1996-3181&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-01 N1 - Date created - 2010-11-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dopamine D1 receptors, regulation of gene expression in the brain, and neurodegeneration. AN - 762029731; 20632973 AB - Dopamine (DA), the most abundant catecholamine in the basal ganglia, participates in the regulation of motor functions and of cognitive processes such as learning and memory. Abnormalities in dopaminergic systems are thought to be the bases for some neuropsychiatric disorders including addiction, Parkinson's disease, and Schizophrenia. DA exerts its arrays of functions via stimulation of D1-like (D1 and D5) and D2-like (D2, D3, and D4) DA receptors which are located in various regions of the brain. The DA D1 and D2 receptors are very abundant in the basal ganglia where they exert their functions within separate neuronal cell types. The present paper focuses on a review of the effects of stimulation of DA D1 receptors on diverse signal transduction pathways and gene expression patterns in the brain. We also discuss the possible involvement of the DA D1 receptors in DA-mediated toxic effects observed both in vitro and in vivo. Future studies using more selective agonist and antagonist agents and the use of genetically modified animals should help to further clarify the role of these receptors in the normal physiology and in pathological events that involve DA. JF - CNS & neurological disorders drug targets AU - Cadet, Jean Lud AU - Jayanthi, Subramaniam AU - McCoy, Michael T AU - Beauvais, Genevieve AU - Cai, Ning Sheng AD - Molecular Neuropsychiatry Research Branch, DHHS/NIH/NIDA Intramural Research Program, Baltimore, MD 21224, USA. jcadet@intra.nida.nih.gov Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 526 EP - 538 VL - 9 IS - 5 KW - Dopamine Agents KW - 0 KW - Nerve Growth Factors KW - Neuropeptides KW - Receptors, Dopamine D1 KW - Transcription Factors KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Neuropeptides -- metabolism KW - Signal Transduction -- physiology KW - Dopamine -- genetics KW - Dopamine -- adverse effects KW - Animals KW - Nerve Growth Factors -- metabolism KW - Transcription Factors -- drug effects KW - Transcription Factors -- metabolism KW - Humans KW - Signal Transduction -- drug effects KW - Dopamine Agents -- pharmacology KW - Dopamine -- physiology KW - Dopamine -- metabolism KW - Receptors, Dopamine D1 -- physiology KW - Receptors, Dopamine D1 -- agonists KW - Receptors, Dopamine D1 -- antagonists & inhibitors KW - Nerve Degeneration -- chemically induced KW - Gene Expression Regulation -- drug effects KW - Brain -- metabolism KW - Receptors, Dopamine D1 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762029731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=CNS+%26+neurological+disorders+drug+targets&rft.atitle=Dopamine+D1+receptors%2C+regulation+of+gene+expression+in+the+brain%2C+and+neurodegeneration.&rft.au=Cadet%2C+Jean+Lud%3BJayanthi%2C+Subramaniam%3BMcCoy%2C+Michael+T%3BBeauvais%2C+Genevieve%3BCai%2C+Ning+Sheng&rft.aulast=Cadet&rft.aufirst=Jean&rft.date=2010-11-01&rft.volume=9&rft.issue=5&rft.spage=526&rft.isbn=&rft.btitle=&rft.title=CNS+%26+neurological+disorders+drug+targets&rft.issn=1996-3181&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-01 N1 - Date created - 2010-11-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Pharmacol. 1984 Oct 1;105(1-2):185-7 [6208043] Mol Pharmacol. 1986 Feb;29(2):113-9 [3005824] Brain Res. 1986 Jun 11;375(2):291-301 [2942221] J 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J Pharmacol Exp Ther. 1999 Mar;288(3):1160-6 [10027854] Brain Res Mol Brain Res. 1999 Mar 20;66(1-2):111-21 [10095083] Neuroscience. 1999 Apr;90(1):69-78 [10188934] Mol Pharmacol. 1999 Aug;56(2):254-64 [10419543] J Recept Signal Transduct Res. 2004 Aug;24(3):107-16 [15521357] Neural Plast. 2004;11(3-4):191-204 [15656268] Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):868-73 [15644446] Int J Biochem Cell Biol. 2005 May;37(5):942-6 [15743669] J Neurosci. 2005 Jun 1;25(22):5273-9 [15930374] Neurobiol Dis. 2005 Nov;20(2):450-60 [15896973] Curr Opin Neurobiol. 2005 Dec;15(6):638-44 [16271465] J Natl Med Assoc. 2005 Nov;97(11):1504-15 [16334497] J Biol Chem. 2004 Oct 1;279(40):42082-94 [15292232] Neuropharmacology. 2004;47 Suppl 1:33-46 [15464124] J Neurosci. 1995 Dec;15(12):7821-36 [8613722] Mol Pharmacol. 1995 Dec;48(6):988-94 [8848015] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pulmonary resection for metastatic gastric cancer. AN - 760237341; 20881648 AB - Sixteen percent of patients with gastric cancer will develop pulmonary metastases. Standard of care for these patients is systemic chemotherapy with a median survival of 6 months and a 5-year survival of only 2%. Our aim was to critically evaluate the published data on pulmonary resection for metastatic gastric cancer (MGC) and to analyze the potential rationale for surgical management to determine which patients may benefit from this approach. The Pubmed and SCOPUS databases were queried for all studies reporting on pulmonary resections for MGC. All available clinicopathologic data were analyzed. Twenty-one studies from 1975 to 2008 reported 48 pulmonary resections in 43 patients including five repeat resections and four extrapulmonary metastasectomies. Eighty-two percent (34/43) of patients had solitary lesions with a median size of 24 mm (4-90 mm). Median time from gastrectomy to pulmonary resection was 35 months (0-120 months). At a median follow-up of 23 months, 15 of 43 (35%) patients were alive without disease, and two patients died without disease. Median survival was 29 months (3-84 months) after pulmonary metastasectomy and 65 months (5-180 months) after gastrectomy. Fifty-six percent (24/43) of patients had another recurrence at a median of 12 months (range: 6-48 months) after resection including 30% (13/43) of patients with pulmonary recurrences. Overall 5-year survival was 33%. Pulmonary metastasectomy for MGC can potentially result in long-term survival in a highly selected group of patients and should be considered for those who present with small, isolated lesions after a prolonged disease-free interval. JF - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer AU - Kemp, Clinton D AU - Kitano, Mio AU - Kerkar, Sid AU - Ripley, R Taylor AU - Marquardt, Jens U AU - Schrump, David S AU - Avital, Itzhak AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1201, USA. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 1796 EP - 1805 VL - 5 IS - 11 KW - Index Medicus KW - Survival Rate KW - Aged, 80 and over KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Meta-Analysis as Topic KW - Male KW - Female KW - Stomach Neoplasms -- pathology KW - Pneumonectomy KW - Stomach Neoplasms -- mortality KW - Stomach Neoplasms -- surgery KW - Lung Neoplasms -- secondary KW - Lung Neoplasms -- mortality KW - Gastrectomy KW - Lung Neoplasms -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760237341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+thoracic+oncology+%3A+official+publication+of+the+International+Association+for+the+Study+of+Lung+Cancer&rft.atitle=Pulmonary+resection+for+metastatic+gastric+cancer.&rft.au=Kemp%2C+Clinton+D%3BKitano%2C+Mio%3BKerkar%2C+Sid%3BRipley%2C+R+Taylor%3BMarquardt%2C+Jens+U%3BSchrump%2C+David+S%3BAvital%2C+Itzhak&rft.aulast=Kemp&rft.aufirst=Clinton&rft.date=2010-11-01&rft.volume=5&rft.issue=11&rft.spage=1796&rft.isbn=&rft.btitle=&rft.title=Journal+of+thoracic+oncology+%3A+official+publication+of+the+International+Association+for+the+Study+of+Lung+Cancer&rft.issn=1556-1380&rft_id=info:doi/10.1097%2FJTO.0b013e3181ed3514 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-17 N1 - Date created - 2010-10-26 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00941655; ClinicalTrials.gov N1 - SuppNotes - Comment In: J Thorac Oncol. 2011 Apr;6(4):836; author reply 836-7 [21623262] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/JTO.0b013e3181ed3514 ER - TY - JOUR T1 - Evolution of functional and sequence variants of the mammalian XPR1 receptor for mouse xenotropic gammaretroviruses and the human-derived retrovirus XMRV. AN - 760237234; 20844050 AB - Genetic conflicts between retroviruses and their receptors result in the evolution of novel host entry restrictions and novel virus envelopes, and such variants can influence trans-species transmission. We screened rodents and other mammals for sequence variation in the Xpr1 receptor for the mouse xenotropic or polytropic mouse leukemia viruses (X-MLVs or P-MLVs, respectively) of the gammaretrovirus family and for susceptibility to mouse-derived X/P-MLVs and to XMRV (xenotropic murine leukemia virus-related virus), an X-MLV-like virus isolated from humans with prostate cancer and chronic fatigue syndrome. We identified multiple distinct susceptibility phenotypes; these include the four known Xpr1 variants in Mus and a novel fifth Xpr1 gene found in Mus molossinus and Mus musculus. We describe the geographic and species distribution of the Mus Xpr1 variants but failed to find the X-MLV-restrictive laboratory mouse allele in any wild mouse. We used mutagenesis and phylogenetic analysis to evaluate the functional contributions made by constrained, variable, and deleted residues. Rodent Xpr1 is under positive selection, indicating a history of host-pathogen conflicts; several codons under selection have known roles in virus entry. All non-Mus mammals are susceptible to mouse X-MLVs, but some restrict other members of the X/P-MLV family, and the resistance of hamster and gerbil cells to XMRV indicates that XMRV has unique receptor requirements. We show that the hypervariable fourth extracellular XPR1 loop (ECL4) contains three evolutionarily constrained residues that do not contribute to receptor function, we identify two novel residues important for virus entry (I579 and T583), and we describe a unique pattern of ECL4 variation in the three virus-restrictive Xpr1 variants found in MLV-infected house mice; these mice carry different deletions in ECL4, suggesting either that these sites or loop size affects receptor function. JF - Journal of virology AU - Yan, Yuhe AU - Liu, Qingping AU - Wollenberg, Kurt AU - Martin, Carrie AU - Buckler-White, Alicia AU - Kozak, Christine A AD - NIH, NIAID, LMM, Bldg. 4, Room 329, 4 Center Drive MSC 0460, Bethesda, MD 20892-0460. ckozak@niaid.nih.gov. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 11970 EP - 11980 VL - 84 IS - 22 KW - Receptors, G-Protein-Coupled KW - 0 KW - Receptors, Virus KW - xenotropic and polytropic retrovirus receptor KW - Index Medicus KW - Phylogeny KW - Animals KW - Cattle KW - Sequence Alignment KW - Guinea Pigs KW - Goats KW - Humans KW - Molecular Sequence Data KW - Dogs KW - Rabbits KW - Mice KW - Amino Acid Sequence KW - Cricetinae KW - Genetic Variation KW - Leukemia Virus, Murine -- genetics KW - Receptors, Virus -- metabolism KW - Receptors, Virus -- genetics KW - Retroviridae Infections -- metabolism KW - Mammals -- genetics KW - Evolution, Molecular KW - Retroviridae Infections -- virology KW - Retroviridae Infections -- veterinary KW - Leukemia Virus, Murine -- physiology KW - Gammaretrovirus -- classification KW - Gammaretrovirus -- genetics KW - Gammaretrovirus -- physiology KW - Gammaretrovirus -- isolation & purification KW - Receptors, G-Protein-Coupled -- metabolism KW - Receptors, G-Protein-Coupled -- genetics KW - Leukemia Virus, Murine -- isolation & purification KW - Mammals -- metabolism KW - Leukemia Virus, Murine -- classification KW - Mammals -- virology KW - Retroviridae Infections -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760237234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Evolution+of+functional+and+sequence+variants+of+the+mammalian+XPR1+receptor+for+mouse+xenotropic+gammaretroviruses+and+the+human-derived+retrovirus+XMRV.&rft.au=Yan%2C+Yuhe%3BLiu%2C+Qingping%3BWollenberg%2C+Kurt%3BMartin%2C+Carrie%3BBuckler-White%2C+Alicia%3BKozak%2C+Christine+A&rft.aulast=Yan&rft.aufirst=Yuhe&rft.date=2010-11-01&rft.volume=84&rft.issue=22&rft.spage=11970&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.01549-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-22 N1 - Date created - 2010-10-26 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - HQ022837; GENBANK; HQ022836; HQ022839; HQ022838; HQ022833; HQ022832; HQ022835; HQ022834; HQ022854; HQ022855; HQ022856; HQ022857; HQ022851; HQ022850; HQ022853; HQ022852; HQ022830; HQ022831; HQ022828; HQ022827; HQ022826; HQ022845; HQ022846; HQ022843; HQ022844; HQ022849; HQ022847; HQ022829; HQ022848; HQ022842; HQ022841; HQ022840 N1 - SuppNotes - Cited By: Nature. 1975 Jan 10;253(5487):140-2 [163009] Genetics. 1972 Oct;72(2):239-52 [4345996] Proc Natl Acad Sci U S A. 1975 Dec;72(12):5150-5 [1061100] J Natl Cancer Inst. 1976 Feb;56(2):423-6 [176389] Proc Natl Acad Sci U S A. 1977 Feb;74(2):789-92 [191826] J Natl Cancer Inst. 1978 Feb;60(2):477-8 [621760] Virology. 1981 Sep;113(2):465-83 [6267794] J Virol. 1984 Jul;51(1):77-80 [6328046] J Virol. 1984 Nov;52(2):695-8 [6092693] Virology. 1985 Jan 30;140(2):239-48 [2982233] Virology. 1985 Feb;141(1):119-29 [2983494] J Virol. 1985 Sep;55(3):690-5 [2991590] Curr Top Microbiol Immunol. 1986;127:62-7 [3731855] J Virol. 1987 Jul;61(7):2225-31 [3035222] J Virol. 1987 Oct;61(10):3082-8 [3041030] Virology. 1989 Feb;168(2):245-55 [2536981] Virology. 1989 Nov;173(1):58-67 [2554579] J Virol. 1992 Jan;66(1):78-84 [1370096] J Virol. 1996 Feb;70(2):830-3 [8551621] Comput Appl Biosci. 1997 Oct;13(5):555-6 [9367129] J Virol. 1998 Oct;72(10):8289-300 [9733873] Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):927-32 [9927670] J Virol. 1999 Mar;73(3):2442-9 [9971829] Nat Genet. 1999 Feb;21(2):216-9 [9988277] Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1385-90 [9990033] J Virol. 1999 Nov;73(11):9362-8 [10516044] Mol Biol Evol. 2005 Apr;22(4):1107-18 [15689528] J Virol. 2005 Aug;79(15):9677-84 [16014929] Retrovirology. 2005;2:76 [16354307] PLoS Pathog. 2006 Mar;2(3):e25 [16609730] PLoS Genet. 2006 Jan;2(1):e2 [16440055] Proc Biol Sci. 2006 Dec 7;273(1604):2925-34 [17015352] Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1655-60 [17234809] Nat Genet. 2007 Sep;39(9):1100-7 [17660819] J Virol. 2007 Oct;81(19):10550-7 [17634227] Cell Mol Life Sci. 2008 Nov;65(21):3383-98 [18818872] Mol Ecol. 2008 Dec;17(24):5349-63 [19121002] Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16351-6 [19805305] Retrovirology. 2009;6:87 [19811656] Science. 2009 Oct 23;326(5952):585-9 [19815723] Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15874-9 [20798047] Syst Biol. 2002 Jun;51(3):410-31 [12079642] Trends Genet. 2003 Jan;19(1):24-31 [12493245] Curr Top Microbiol Immunol. 2003;281:29-106 [12932075] J Virol. 2003 Dec;77(23):12773-81 [14610199] Nucleic Acids Res. 2004;32(5):1792-7 [15034147] Syst Biol. 2004 Aug;53(4):533-53 [15371245] Science. 1970 Oct 16;170(3955):326-7 [4318971] Int J Cancer. 1975 Feb 15;15(2):211-20 [47844] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.01549-10 ER - TY - JOUR T1 - Development of an image analysis screen for estrogen receptor alpha (ERα) ligands through measurement of nuclear translocation dynamics. AN - 760236921; 20816963 AB - We have developed a robust high-content assay to screen for novel estrogen receptor alpha (ERα) agonists and antagonists by quantitation of cytoplasmic to nuclear translocation of an estrogen receptor chimera in 384-well plates. The screen utilizes a green fluorescent protein tagged-glucocorticoid/estrogen receptor (GFP-GRER) chimera which consisted of the N-terminus of the glucocorticoid receptor fused to the human ER ligand binding domain. The GFP-GRER exhibited cytoplasmic localization in the absence of ERα ligands, and translocated to the nucleus in response to stimulation with ERα agonists or antagonists. The BD Pathway 435 imaging system was used for image acquisition, analysis of translocation dynamics, and cytotoxicity measurements. The assay was validated with known ERα agonists and antagonists, and the Library of Pharmacologically Active Compounds (LOPAC 1280). Additionally, screening of crude natural product extracts demonstrated the robustness of the assay, and the ability to quantitate the effects of toxicity on nuclear translocation dynamics. The GFP-GRER nuclear translocation assay was very robust, with z' values >0.7, CVs <5%, and has been validated with known ER ligands, and inclusion of cytotoxicity filters will facilitate screening of natural product extracts. This assay has been developed for future primary screening of synthetic, pure natural products, and natural product extracts libraries available at the National Cancer Institute at Frederick. Copyright © 2010 Elsevier Ltd. All rights reserved. JF - The Journal of steroid biochemistry and molecular biology AU - Dull, Angie AU - Goncharova, Ekaterina AU - Hager, Gordon AU - McMahon, James B AD - Molecular Targets Laboratory, SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, Maryland 21702, United States. dulla@mail.nih.gov Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 341 EP - 351 VL - 122 IS - 5 KW - Antineoplastic Agents KW - 0 KW - Estrogen Receptor alpha KW - Ligands KW - Mutant Chimeric Proteins KW - Receptors, Estrogen KW - Receptors, Glucocorticoid KW - estrogen receptor alpha, human KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Index Medicus KW - Animals KW - Humans KW - Cell Line, Tumor KW - Mice KW - Receptors, Estrogen -- metabolism KW - Receptors, Glucocorticoid -- metabolism KW - False Positive Reactions KW - Mutant Chimeric Proteins -- metabolism KW - Antineoplastic Agents -- analysis KW - Mammary Neoplasms, Experimental KW - Green Fluorescent Proteins -- metabolism KW - Female KW - Estrogen Receptor alpha -- antagonists & inhibitors KW - Estrogen Receptor alpha -- metabolism KW - Estrogen Receptor alpha -- agonists KW - Drug Evaluation, Preclinical -- methods KW - Protein Transport UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760236921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+steroid+biochemistry+and+molecular+biology&rft.atitle=Development+of+an+image+analysis+screen+for+estrogen+receptor+alpha+%28ER%CE%B1%29+ligands+through+measurement+of+nuclear+translocation+dynamics.&rft.au=Dull%2C+Angie%3BGoncharova%2C+Ekaterina%3BHager%2C+Gordon%3BMcMahon%2C+James+B&rft.aulast=Dull&rft.aufirst=Angie&rft.date=2010-11-01&rft.volume=122&rft.issue=5&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+steroid+biochemistry+and+molecular+biology&rft.issn=1879-1220&rft_id=info:doi/10.1016%2Fj.jsbmb.2010.08.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-23 N1 - Date created - 2010-10-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Carcinogenesis. 2001 Mar;22(3):489-97 [11238191] Drugs. 2008;68(14):2059-83 [18778124] Intern Med. 2002 May;41(5):345-50 [12058881] JAMA. 2002 Jul 17;288(3):321-33 [12117397] JAMA. 2003 Jun 25;289(24):3243-53 [12824205] Lancet. 2003 Aug 9;362(9382):419-27 [12927427] Assay Drug Dev Technol. 2003 Dec;1(6):789-800 [15090225] J Clin Endocrinol Metab. 1973 Feb;36(2):207-14 [4688315] Proc Natl Acad Sci U S A. 1986 Apr;83(8):2496-500 [3458212] Cancer Res. 1988 May 15;48(10):2837-57 [3129189] Crit Rev Oncog. 1993;4(4):403-17 [8353140] Carcinogenesis. 1996 Mar;17(3):585-94 [8631149] Carcinogenesis. 1997 Nov;18(11):2247-53 [9395228] Carcinogenesis. 1999 Jul;20(7):1153-60 [10383884] Endocr Relat Cancer. 2004 Dec;11(4):643-58 [15613444] BMJ. 2005 Apr 23;330(7497):932 [15746106] Assay Drug Dev Technol. 2005 Aug;3(4):393-400 [16180994] J Steroid Biochem Mol Biol. 2005 Dec;97(4):307-21 [16162406] Int J Gynecol Cancer. 2008 Mar-Apr;18(2):352-6 [18334013] Chem Res Toxicol. 2001 Aug;14(8):1041-50 [11511178] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jsbmb.2010.08.009 ER - TY - JOUR T1 - Amplification of CyclinL1 in uterine cervical carcinoma has prognostic implications. AN - 759325858; 20721974 AB - The chromosomal 3q25.31 region was consistently amplified in primary cancer of cervix (CACX). CyclinL1 is a candidate gene of this region and already have been implicated as an oncogene in head and neck cancers. In this study, we aimed to investigate the involvement of CyclinL1 in cervical carcinogenesis and for this purpose its copy number variation (CNV) was studied in 23 cervical intraepithelial neoplasia (CIN) and 110 CACX samples. In CIN lesions CyclinL1 was not amplified; however, the amplification frequency was 16% (9/56) in stage I/II tumors which remained comparable during subsequent stages of tumorigenesis. This implied association of CyclinL1 amplification with development of early invasiveness. Quantitation of mRNA expression revealed 2.6 ± 1.53-fold overexpression of this gene in primary CACX. The amplification/copy number gain of CyclinL1 and its mRNA profile were concordant, in tumors. Immunohistochemical (IHC) analysis in primary CACX, cell lines: SiHa and HeLa revealed intense nuclear expression of cyclinL1, which was further confirmed by Western blot in the cell lines. However 47% (7/15) CACX samples expressed high/intermediate level of cyclin L1. Kaplan-Meier survival analysis indicated CyclinL1 amplification as a determinant of poor patient outcome. Tumor radio-resistance developed as a consequence of CyclinL1 amplification. Cox multivariate analysis revealed that multiparous (≥5) CACX patients with amplified CyclinL1 locus along with advanced tumor stage (III/IV) had worst prognosis. Our data suggest importance of CyclinL1 in cervical carcinogenesis with its associated pathways viz: pre-mRNA splicing, cell-cycle regulation (G₀/G₁ and G₂/M) being potential targets of therapeutic interventions in CACX. © 2010 Wiley-Liss, Inc. JF - Molecular carcinogenesis AU - Mitra, Sraboni AU - Mazumder Indra, Dipanjana AU - Basu, Partha S AU - Mondal, Ranajit K AU - Roy, Anup AU - Roychoudhury, Susanta AU - Panda, Chinmay K AD - Department of Oncogene Regulation, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 935 EP - 943 VL - 49 IS - 11 KW - CCNL1 protein, human KW - 0 KW - Cyclins KW - RNA, Messenger KW - Index Medicus KW - Cervix Uteri -- pathology KW - Young Adult KW - Humans KW - Cervix Uteri -- metabolism KW - Prognosis KW - Child KW - RNA, Messenger -- genetics KW - Blotting, Western KW - Tumor Cells, Cultured KW - Survival Rate KW - Adult KW - Case-Control Studies KW - Adolescent KW - Gene Dosage KW - Female KW - Immunoenzyme Techniques KW - Cervical Intraepithelial Neoplasia -- pathology KW - Cervical Intraepithelial Neoplasia -- genetics KW - Uterine Cervical Neoplasms -- metabolism KW - Cervical Intraepithelial Neoplasia -- metabolism KW - Cyclins -- metabolism KW - Uterine Cervical Neoplasms -- genetics KW - Uterine Cervical Neoplasms -- pathology KW - Cyclins -- genetics KW - Gene Amplification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759325858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Amplification+of+CyclinL1+in+uterine+cervical+carcinoma+has+prognostic+implications.&rft.au=Mitra%2C+Sraboni%3BMazumder+Indra%2C+Dipanjana%3BBasu%2C+Partha+S%3BMondal%2C+Ranajit+K%3BRoy%2C+Anup%3BRoychoudhury%2C+Susanta%3BPanda%2C+Chinmay+K&rft.aulast=Mitra&rft.aufirst=Sraboni&rft.date=2010-11-01&rft.volume=49&rft.issue=11&rft.spage=935&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=1098-2744&rft_id=info:doi/10.1002%2Fmc.20671 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-09 N1 - Date created - 2010-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/mc.20671 ER - TY - JOUR T1 - Base excision repair and design of small molecule inhibitors of human DNA polymerase β. AN - 759138002; 20844920 AB - Base excision repair (BER) can protect a cell after endogenous or exogenous genotoxic stress, and a deficiency in BER can render a cell hypersensitive to stress-induced apoptotic and necrotic cell death, mutagenesis, and chromosomal rearrangements. However, understanding of the mammalian BER system is not yet complete as it is extraordinarily complex and has many back-up processes that complement a deficiency in any one step. Due of this lack of information, we are unable to make accurate predictions on therapeutic approaches targeting BER. A deeper understanding of BER will eventually allow us to conduct more meaningful clinical interventions. In this review, we will cover historical and recent information on mammalian BER and DNA polymerase β and discuss approaches toward development and use of small molecule inhibitors to manipulate BER. With apologies to others, we will emphasize results obtained in our laboratory and those of our collaborators. JF - Cellular and molecular life sciences : CMLS AU - Wilson, Samuel H AU - Beard, William A AU - Shock, David D AU - Batra, Vinod K AU - Cavanaugh, Nisha A AU - Prasad, Rajendra AU - Hou, Esther W AU - Liu, Yuan AU - Asagoshi, Kenjiro AU - Horton, Julie K AU - Stefanick, Donna F AU - Kedar, Padmini S AU - Carrozza, Michael J AU - Masaoka, Aya AU - Heacock, Michelle L AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA. wilson5@niehs.nih.gov Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 3633 EP - 3647 VL - 67 IS - 21 KW - Enzyme Inhibitors KW - 0 KW - DNA Polymerase beta KW - EC 2.7.7.- KW - Index Medicus KW - High-Throughput Screening Assays KW - Animals KW - Models, Molecular KW - Humans KW - DNA Polymerase beta -- antagonists & inhibitors KW - Enzyme Inhibitors -- chemistry KW - DNA Polymerase beta -- chemistry KW - Enzyme Inhibitors -- pharmacology KW - DNA Repair -- drug effects KW - DNA Polymerase beta -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759138002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+and+molecular+life+sciences+%3A+CMLS&rft.atitle=Base+excision+repair+and+design+of+small+molecule+inhibitors+of+human+DNA+polymerase+%CE%B2.&rft.au=Wilson%2C+Samuel+H%3BBeard%2C+William+A%3BShock%2C+David+D%3BBatra%2C+Vinod+K%3BCavanaugh%2C+Nisha+A%3BPrasad%2C+Rajendra%3BHou%2C+Esther+W%3BLiu%2C+Yuan%3BAsagoshi%2C+Kenjiro%3BHorton%2C+Julie+K%3BStefanick%2C+Donna+F%3BKedar%2C+Padmini+S%3BCarrozza%2C+Michael+J%3BMasaoka%2C+Aya%3BHeacock%2C+Michelle+L&rft.aulast=Wilson&rft.aufirst=Samuel&rft.date=2010-11-01&rft.volume=67&rft.issue=21&rft.spage=3633&rft.isbn=&rft.btitle=&rft.title=Cellular+and+molecular+life+sciences+%3A+CMLS&rft.issn=1420-9071&rft_id=info:doi/10.1007%2Fs00018-010-0489-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-16 N1 - Date created - 2010-10-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Structure. 2003 May;11(5):489-96 [12737815] DNA Repair (Amst). 2004 Jun 3;3(6):581-91 [15135726] J Biol Chem. 2004 Jul 23;279(30):31921-9 [15145936] Mol Cell. 2004 Jul 23;15(2):209-20 [15260972] J Biol Chem. 2004 Sep 17;279(38):39736-44 [15258144] Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13738-43 [15365186] Structure. 2004 Oct;12(10):1823-32 [15458631] Proc Natl Acad Sci U S A. 1974 Sep;71(9):3649-53 [4610583] Mol Gen Genet. 1984;197(3):368-72 [6098799] Biochem Biophys Res Commun. 1986 Apr 14;136(1):341-7 [2423078] Proc Natl Acad Sci U S A. 1986 Jul;83(14):5106-10 [2873575] Biochim Biophys Acta. 1988 Feb 28;949(2):149-57 [3277667] Biochemistry. 1988 Feb 9;27(3):901-9 [3284575] J Biol Chem. 1988 Oct 15;263(29):15094-103 [2971662] Mol Cell Biol. 1989 Feb;9(2):851-3 [2710127] DNA Repair (Amst). 2010 Aug 5;9(8):929-36 [20573551] J Biol Chem. 2010 Aug 6;285(32):24457-65 [20519499] Nucleic Acids Res. 1995 Oct 11;23(19):3810-5 [7479021] Methods Enzymol. 1995;262:98-107 [8594388] Nature. 1996 Jan 11;379(6561):183-6 [8538772] J Biol Chem. 1996 Apr 19;271(16):9573-8 [8621631] Biochemistry. 1996 May 21;35(20):6188-200 [8639559] J Biol Chem. 1996 Jul 5;271(27):16000-7 [8663274] J Biol Chem. 1996 Jul 26;271(30):17811-5 [8663612] Biochemistry. 1996 Oct 1;35(39):12742-61 [8841118] Biochemistry. 1996 Oct 1;35(39):12762-77 [8841119] Nucleic Acids Res. 1996 Nov 15;24(22):4387-94 [8948628] Nucleic Acids Res. 1997 Feb 15;25(4):750-5 [9016624] Biochemistry. 1997 Sep 16;36(37):11205-15 [9287163] Chem Biol. 1998 Jan;5(1):R7-13 [9479474] Science. 1999 Dec 3;286(5446):1897-905 [10583946] Protein Expr Purif. 2000 Feb;18(1):100-10 [10648175] Nat Struct Biol. 2000 Mar;7(3):176-8 [10700268] Nucleic Acids Res. 2000 May 15;28(10):2049-59 [10773072] Nature. 2000 Jun 15;405(6788):807-10 [10866204] Mutat Res. 2000 Jun 30;451(1-2):39-51 [10915864] Mutat Res. 2000 Aug 30;460(3-4):231-44 [10946231] J Biol Chem. 2001 Jul 6;276(27):25541-8 [11340072] Prog Nucleic Acid Res Mol Biol. 2001;68:365-86 [11554311] Structure. 2001 Sep;9(9):759-64 [11566124] Nat Struct Biol. 2001 Nov;8(11):915-7 [11685231] J Biol Chem. 2002 Dec 6;277(49):47393-8 [12370169] Structure. 2002 Dec;10(12):1709-20 [12467578] DNA Repair (Amst). 2002 Apr 29;1(4):317-33 [12509250] DNA Repair (Amst). 2003 Jan 2;2(1):27-48 [12509266] J Biol Chem. 1990 Feb 5;265(4):2124-31 [2404980] Proc Natl Acad Sci U S A. 1990 Aug;87(15):5842-5 [2116008] J Biol Chem. 1990 Oct 5;265(28):17094-100 [2145269] Somat Cell Mol Genet. 1990 Jul;16(4):311-20 [1699288] Mol Cell Biol. 1991 Sep;11(9):4441-7 [1875931] J Biol Chem. 1991 Oct 15;266(29):19618-25 [1918069] Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11450-4 [1722334] Mol Cell Biol. 1992 Apr;12(4):1605-12 [1549115] Biochemistry. 1992 Oct 27;31(42):10272-80 [1420147] J Biol Chem. 1993 Jul 25;268(21):15906-11 [8340415] J Biol Chem. 1993 Oct 25;268(30):22746-55 [8226785] J Biol Chem. 1993 Dec 25;268(36):27148-53 [8262953] Mol Cell Biol. 1994 Jan;14(1):68-76 [8264637] Nucleic Acids Res. 1993 Nov 25;21(23):5301-7 [8265341] Science. 1994 Jun 24;264(5167):1891-903 [7516580] Science. 1994 Jun 24;264(5167):1930-5 [7516581] Biochemistry. 1994 Aug 16;33(32):9537-45 [8068628] J Mol Biol. 1994 Nov 25;244(2):224-35 [7966332] J Biol Chem. 1995 Jan 13;270(2):949-57 [7822335] Nucleic Acids Res. 1998 Apr 15;26(8):2001-7 [9518496] J Biol Chem. 1998 May 1;273(18):11121-6 [9556598] Mutat Res. 1998 Jun;407(3):203-15 [9653447] Carcinogenesis. 1999 Jun;20(6):1049-54 [10357787] Mol Cell. 1999 Sep;4(3):439-44 [10518225] J Biol Chem. 2005 Apr 22;280(16):15773-85 [15701627] DNA Repair (Amst). 2005 Sep 28;4(10):1111-20 [16002346] Chem Rev. 2006 Feb;106(2):361-82 [16464010] Structure. 2006 Apr;14(4):757-66 [16615916] Methods Enzymol. 2006;408:91-107 [16793365] Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13294-9 [16938895] Biochemistry. 2006 Dec 26;45(51):15142-56 [17176036] Biochemistry. 2007 Jan 16;46(2):461-71 [17209556] Mutat Res. 2007 Jan 3;614(1-2):69-76 [16769088] DNA Repair (Amst). 2007 Apr 1;6(4):530-43 [17113833] J Biol Chem. 2007 May 4;282(18):13532-41 [17355977] Nucleic Acids Res. 2007;35(17):e112 [17720705] Cell Res. 2008 Jan;18(1):48-63 [18166976] Biochemistry. 2008 Jan 22;47(3):870-9 [18161950] Mol Cell. 2008 May 9;30(3):315-24 [18471977] DNA Repair (Amst). 2008 Nov 1;7(11):1787-98 [18691676] J Biol Chem. 2009 Oct 9;284(41):28352-66 [19674974] DNA Repair (Amst). 2009 Nov 2;8(11):1264-72 [19717351] DNA Repair (Amst). 2009 Nov 2;8(11):1290-9 [19748837] Nucleic Acids Res. 2009 Oct;37(19):e128 [19684079] DNA Repair (Amst). 2010 Feb 4;9(2):109-19 [20006562] Nat Rev Cancer. 2010 Apr;10(4):293-301 [20200537] Structure. 2003 Jan;11(1):121-7 [12517346] Nucleic Acids Res. 2003 May 1;31(9):2261-71 [12711670] DNA Repair (Amst). 2003 May 13;2(5):609-22 [12713817] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00018-010-0489-1 ER - TY - JOUR T1 - Cancer in experimental animals exposed to arsenic and arsenic compounds. AN - 758836630; 20812815 AB - Inorganic arsenic is a ubiquitous environmental contaminant that has long been considered a human carcinogen. Recent studies raise further concern about the metalloid as a major, naturally occurring carcinogen in the environment. However, during this same period it has proven difficult to provide experimental evidence of the carcinogenicity of inorganic arsenic in laboratory animals and, until recently, there was considered to be a lack of clear evidence for carcinogenicity of any arsenical in animals. More recent work with arsenical methylation metabolites and early life exposures to inorganic arsenic has now provided evidence of carcinogenicity in rodents. Given that tens of millions of people worldwide are exposed to potentially unhealthy levels of environmental arsenic, in vivo rodent models of arsenic carcinogenesis are a clear necessity for resolving critical issues, such as mechanisms of action, target tissue specificity, and sensitive subpopulations, and in developing strategies to reduce cancers in exposed human populations. This work reviews the available rodent studies considered relevant to carcinogenic assessment of arsenicals, taking advantage of the most recent review by the International Agency for Research on Cancer (IARC) that has not yet appeared as a full monograph but has been summarized (IARC, 2009 , IARC Special Report: Policy, Vol. 10. Lyon: IARC Press, 453–454). Many valid studies show that arsenic can interact with other carcinogens/agents to enhance oncogenesis, and help elucidate mechanisms, and these too are summarized in this review. Finally, this body of rodent work is discussed in light of its impact on mechanisms and in the context of the persistent argument that arsenic is not carcinogenic in animals. JF - Critical reviews in toxicology AU - Tokar, Erik J AU - Benbrahim-Tallaa, Lamia AU - Ward, Jerrold M AU - Lunn, Ruth AU - Sams, Reeder L AU - Waalkes, Michael P AD - National Toxicology Program, National Institute of Environmental Health Sciences, and Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 912 EP - 927 VL - 40 IS - 10 KW - Arsenicals KW - 0 KW - Carcinogens KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Humans KW - Disease Models, Animal KW - Mice KW - Methylation KW - Male KW - Female KW - Arsenic -- toxicity KW - Neoplasms -- chemically induced KW - Carcinogens -- toxicity KW - Arsenicals -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758836630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+toxicology&rft.atitle=Cancer+in+experimental+animals+exposed+to+arsenic+and+arsenic+compounds.&rft.au=Tokar%2C+Erik+J%3BBenbrahim-Tallaa%2C+Lamia%3BWard%2C+Jerrold+M%3BLunn%2C+Ruth%3BSams%2C+Reeder+L%3BWaalkes%2C+Michael+P&rft.aulast=Tokar&rft.aufirst=Erik&rft.date=2010-11-01&rft.volume=40&rft.issue=10&rft.spage=912&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+toxicology&rft.issn=1547-6898&rft_id=info:doi/10.3109%2F10408444.2010.506641 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-20 N1 - Date created - 2010-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: IARC Monogr Eval Carcinog Risks Hum Suppl. 1987;7:1-440 [3482203] Environ Health Perspect. 2010 Jan;118(1):108-15 [20056578] Carcinogenesis. 1996 Apr;17(4):767-70 [8625489] Carcinogenesis. 1996 Nov;17(11):2435-9 [8968060] Mutat Res. 1997 Jun;386(3):181-4 [9219556] Mutat Res. 1997 Jun;386(3):209-18 [9219559] Cancer Lett. 1998 Mar 13;125(1-2):83-8 [9566700] Am J Pathol. 1998 Dec;153(6):1775-85 [9846968] Cancer Lett. 1998 Dec 11;134(1):29-36 [10381127] Carcinogenesis. 1999 Sep;20(9):1873-6 [10469637] Cancer Lett. 2005 Jun 1;223(1):27-35 [15890234] Toxicol Lett. 2005 Aug 14;158(2):87-94 [16039397] Toxicol Appl Pharmacol. 2005 Aug 22;207(1):69-77 [16054901] Carcinogenesis. 2005 Dec;26(12):2179-86 [16014701] Cancer Res. 2006 Feb 1;66(3):1337-45 [16452187] Toxicol Sci. 2006 Jun;91(2):372-81 [16543296] Toxicology. 2006 Jun 1;223(1-2):82-100 [16677751] Environ Health Perspect. 2006 Aug;114(8):1293-6 [16882542] Toxicol Appl Pharmacol. 2006 Sep 15;215(3):295-305 [16712894] Ann N Y Acad Sci. 2006 Sep;1076:578-91 [17119234] Lab Invest. 2006 Dec;86(12):1203-7 [17075578] IARC Monogr Eval Carcinog Risks Hum. 2006;87:1-471 [17191367] Cancer Lett. 2000 Apr 28;152(1):79-85 [10754209] Environ Health Perspect. 2000 Jun;108 Suppl 3:573-94 [10852857] Jpn J Cancer Res. 2000 Jun;91(6):579-81 [10874208] Toxicol Appl Pharmacol. 2000 Jul 1;166(1):24-35 [10873715] Toxicol Lett. 2000 Jul 27;116(1-2):27-35 [10906419] Biol Pharm Bull. 2001 May;24(5):510-4 [11379771] Toxicol Appl Pharmacol. 2001 Oct 1;176(1):64-71 [11578149] Carcinogenesis. 2002 Aug;23(8):1387-97 [12151359] Carcinogenesis. 2003 Feb;24(2):335-42 [12584185] Toxicol Appl Pharmacol. 2003 Jan 1;186(1):7-17 [12583988] Toxicology. 2003 Aug 28;190(3):197-219 [12927375] Carcinogenesis. 2003 Nov;24(11):1827-35 [12919961] Carcinogenesis. 2004 Jan;25(1):133-41 [14514661] Environ Health Perspect. 2004 Apr;112(5):599-603 [15064167] Verh Dtsch Ges Pathol. 1971;55:289-93 [4130723] Int J Cancer. 1979 Dec 15;24(6):786-8 [544532] Proc West Pharmacol Soc. 1983;26:413-5 [6688469] Cancer Lett. 1983 Dec;21(2):141-7 [6652618] Environ Res. 1984 Aug;34(2):227-41 [6086305] Cancer Lett. 1985 May;27(1):99-104 [4005826] Vopr Onkol. 1986;32(3):68-73 [3962260] Int J Cancer. 1987 Aug 15;40(2):220-3 [3610389] Cancer Sci. 2007 Jun;98(6):803-14 [17441966] Toxicol Appl Pharmacol. 2007 May 15;221(1):119-28 [17400267] Toxicol Appl Pharmacol. 2007 Aug 1;222(3):258-63 [17109909] Toxicol Appl Pharmacol. 2007 Aug 1;222(3):271-80 [17306315] Toxicol Appl Pharmacol. 2007 Dec 1;225(2):206-13 [17765279] Curr Opin Biotechnol. 2007 Oct;18(5):460-6 [18023337] J Pharmacokinet Pharmacodyn. 2008 Feb;35(1):31-68 [17943421] Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):1982-7 [18708388] Cancer Res. 2008 Oct 15;68(20):8278-85 [18922899] Toxicol Appl Pharmacol. 2008 Nov 1;232(3):359-68 [18687352] J Expo Sci Environ Epidemiol. 2009 May;19(4):343-8 [19190673] Lancet Oncol. 2009 May;10(5):453-4 [19418618] Endocr Pathol. 2008 Spring;19(1):9-16 [18317952] Crit Rev Toxicol. 2009;39(8):695-718 [19743946] Cancer Res. 1995 Mar 15;55(6):1271-6 [7882321] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/10408444.2010.506641 ER - TY - JOUR T1 - Pulmonary infections and risk of lung cancer among persons with AIDS. AN - 758835897; 20736841 AB - Lung cancer risk is significantly increased among persons with AIDS (PWA), and increased smoking may not explain all of the elevated risk, suggesting a role for additional cofactors. We investigated whether AIDS-defining pulmonary infections (recurrent pneumonia, Pneumocystis jirovecii pneumonia, and pulmonary tuberculosis) affected the risk of subsequent lung cancer over 10 years after AIDS onset among 322,675 PWA, whose records were linked with cancer registries in 11 US regions. We assessed lung cancer hazard ratios (HRs) using Cox regression and indirectly adjusted HRs for confounding by smoking. Individuals with recurrent pneumonia (n = 5317) were at significantly higher lung cancer risk than those without [HR = 1.63, 95% confidence interval (CI) = 1.08 to 2.46, adjusted for age, race, sex, HIV acquisition mode, CD4 count, and AIDS diagnosis year]. This association was especially strong among young PWA (<50 years HR = 1.99 vs. ≥50 years HR = 1.10) and was significantly elevated during 5-10 years after recurrent pneumonia diagnosis (HR = 2.41; 95% CI = 1.07 to 5.47). Although attenuated, HRs for recurrent pneumonia remained nonsignificantly elevated after indirect adjustment for smoking. Lung cancer risk was unrelated to tuberculosis [(n = 13,878) HR = 1.12, 95% CI = 0.82 to 1.53] or Pneumocystis jirovecii pneumonia [(n = 69,771) HR = 0.97, 95% CI = 0.80 to 1.18]. The increased lung cancer risk associated with recurrent pneumonia supports the hypothesis that chronic pulmonary inflammation arising from infections contributes to lung carcinogenesis. JF - Journal of acquired immune deficiency syndromes (1999) AU - Shebl, Fatma M AU - Engels, Eric A AU - Goedert, James J AU - Chaturvedi, Anil K AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 375 EP - 379 VL - 55 IS - 3 KW - Index Medicus KW - AIDS/HIV KW - United States KW - Young Adult KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Adolescent KW - Male KW - Female KW - Risk Assessment KW - Acquired Immunodeficiency Syndrome -- complications KW - AIDS-Related Opportunistic Infections -- complications KW - Lung Neoplasms -- epidemiology KW - Tuberculosis, Pulmonary -- complications KW - Pneumonia, Pneumocystis -- complications KW - Pneumonia, Bacterial -- complications KW - AIDS-Related Opportunistic Infections -- microbiology KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758835897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.atitle=Pulmonary+infections+and+risk+of+lung+cancer+among+persons+with+AIDS.&rft.au=Shebl%2C+Fatma+M%3BEngels%2C+Eric+A%3BGoedert%2C+James+J%3BChaturvedi%2C+Anil+K&rft.aulast=Shebl&rft.aufirst=Fatma&rft.date=2010-11-01&rft.volume=55&rft.issue=3&rft.spage=375&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.issn=1944-7884&rft_id=info:doi/10.1097%2FQAI.0b013e3181eef4f7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-04 N1 - Date created - 2010-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Intern Med. 2000 Mar 7;132(5):369-72 [10691587] Lung Cancer. 2010 Apr;68(1):20-6 [19545930] Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):612-6 [10934095] Int J Cancer. 2003 May 20;105(1):101-7 [12672038] Am J Epidemiol. 2004 Aug 15;160(4):384-92 [15286024] MMWR Morb Mortal Wkly Rep. 1993 Apr 30;42(16):308-10 [8474424] Am J Epidemiol. 1993 Dec 1;138(11):909-22 [8256779] Am J Epidemiol. 1995 Jun 1;141(11):1023-32 [7771438] N Engl J Med. 1995 Sep 28;333(13):845-51 [7651475] Am J Epidemiol. 1999 Jan 1;149(1):13-20 [9883789] Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):773-8 [15824142] Arch Intern Med. 2005 Jul 11;165(13):1533-40 [16009870] J Clin Oncol. 2006 Mar 20;24(9):1383-8 [16549832] Lung Cancer. 2006 Jul;53(1):5-12 [16733074] AIDS. 2006 Aug 1;20(12):1645-54 [16868446] AIDS. 2007 Jan 11;21(2):207-13 [17197812] Arch Intern Med. 2007 Feb 26;167(4):335-42 [17325294] Clin Infect Dis. 2007 Jul 1;45(1):103-10 [17554710] Expert Rev Anticancer Ther. 2008 Apr;8(4):605-15 [18402527] Respirology. 2008 Jun;13(4):585-9 [18410259] Int J Cancer. 2009 Mar 1;124(5):1183-7 [19058197] Int J Cancer. 2009 Dec 15;125(12):2936-44 [19521963] Lancet Oncol. 2009 Dec;10(12):1152-9 [19818686] JAMA. 2000 Aug 9;284(6):706-12 [10927778] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/QAI.0b013e3181eef4f7 ER - TY - JOUR T1 - The beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivo. AN - 757795222; 20805354 AB - Eukaryotic translation initiation factor 2B (eIF2B) is the guanine nucleotide exchange factor (GEF) for eukaryotic translation initiation factor 2, which stimulates formation of the eIF2-GTP-Met-tRNA(i)(Met) ternary complex (TC) in a manner inhibited by phosphorylated eIF2 [eIF2(αP)]. While eIF2B contains five subunits, the ε/Gcd6 subunit is sufficient for GEF activity in vitro. The δ/Gcd2 and β/Gcd7 subunits function with α/Gcn3 in the eIF2B regulatory subcomplex that mediates tight, inhibitory binding of eIF2(αP)-GDP, but the essential functions of δ/Gcd2 and β/Gcd7 are not well understood. We show that the depletion of wild-type β/Gcd7, three lethal β/Gcd7 amino acid substitutions, and a synthetically lethal combination of substitutions in β/Gcd7 and eIF2α all impair eIF2 binding to eIF2B without reducing ε/Gcd6 abundance in the native eIF2B-eIF2 holocomplex. Additionally, β/Gcd7 mutations that impair eIF2B function display extensive allele-specific interactions with mutations in the S1 domain of eIF2α (harboring the phosphorylation site), which binds to eIF2B directly. Consistent with this, β/Gcd7 can overcome the toxicity of eIF2(αP) and rescue native eIF2B function when overexpressed with δ/Gcd2 or γ/Gcd1. In aggregate, these findings provide compelling evidence that β/Gcd7 is crucial for binding of substrate by eIF2B in vivo, beyond its dispensable regulatory role in the inhibition of eIF2B by eIF (αP). JF - Molecular and cellular biology AU - Dev, Kamal AU - Qiu, Hongfang AU - Dong, Jinsheng AU - Zhang, Fan AU - Barthlme, Dominik AU - Hinnebusch, Alan G AD - Laboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 5218 EP - 5233 VL - 30 IS - 21 KW - DNA Primers KW - 0 KW - Eukaryotic Initiation Factor-2 KW - Eukaryotic Initiation Factor-2B KW - GCD2 protein, S cerevisiae KW - GCD7 protein, S cerevisiae KW - Protein Subunits KW - RNA, Fungal KW - RNA, Transfer, Met KW - Recombinant Proteins KW - Saccharomyces cerevisiae Proteins KW - Index Medicus KW - RNA, Fungal -- genetics KW - RNA, Transfer, Met -- genetics KW - Genes, Fungal KW - DNA Primers -- genetics KW - Models, Molecular KW - RNA, Fungal -- metabolism KW - Recombinant Proteins -- genetics KW - Models, Biological KW - Protein Binding KW - Saccharomyces cerevisiae -- genetics KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Saccharomyces cerevisiae -- metabolism KW - Recombinant Proteins -- metabolism KW - RNA, Transfer, Met -- metabolism KW - Recombinant Proteins -- chemistry KW - Mutation KW - Amino Acid Substitution KW - Saccharomyces cerevisiae Proteins -- metabolism KW - Eukaryotic Initiation Factor-2B -- chemistry KW - Eukaryotic Initiation Factor-2B -- metabolism KW - Saccharomyces cerevisiae Proteins -- genetics KW - Eukaryotic Initiation Factor-2 -- metabolism KW - Eukaryotic Initiation Factor-2B -- genetics KW - Saccharomyces cerevisiae Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/757795222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=The+beta%2FGcd7+subunit+of+eukaryotic+translation+initiation+factor+2B+%28eIF2B%29%2C+a+guanine+nucleotide+exchange+factor%2C+is+crucial+for+binding+eIF2+in+vivo.&rft.au=Dev%2C+Kamal%3BQiu%2C+Hongfang%3BDong%2C+Jinsheng%3BZhang%2C+Fan%3BBarthlme%2C+Dominik%3BHinnebusch%2C+Alan+G&rft.aulast=Dev&rft.aufirst=Kamal&rft.date=2010-11-01&rft.volume=30&rft.issue=21&rft.spage=5218&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=1098-5549&rft_id=info:doi/10.1128%2FMCB.00265-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-05 N1 - Date created - 2010-10-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1999 Nov 5;274(45):32198-203 [10542257] Mol Cell Biol. 1993 Mar;13(3):1920-32 [8441423] Science. 2000 Jun 2;288(5471):1643-7 [10834843] Biochim Biophys Acta. 2000 Jun 21;1492(1):56-62 [10858531] Genetics. 2001 May;158(1):123-32 [11333223] J Biol Chem. 2001 Jul 6;276(27):24697-703 [11323413] Mol Cell Biol. 2001 Aug;21(15):5018-30 [11438658] EMBO J. 2002 Oct 1;21(19):5292-301 [12356745] J Mol Biol. 2004 Jan 23;335(4):923-36 [14698289] Mol Cell Biol. 2004 Mar;24(6):2352-63 [14993275] J Biol Chem. 1982 Nov 10;257(21):13056-61 [6290491] Gene. 1987;57(2-3):267-72 [3319781] Methods Enzymol. 1987;154:164-75 [3323810] Science. 1988 Oct 7;242(4875):93-7 [3051379] Gene. 1988 Dec 30;74(2):527-34 [3073106] Genetics. 1989 May;122(1):19-27 [2659436] Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7215-9 [8102207] Science. 1994 Mar 4;263(5151):1273-6 [8122109] Mol Cell Biol. 1994 May;14(5):3208-22 [8164676] Mol Cell Biol. 1994 Dec;14(12):7920-32 [7969132] Yeast. 1995 Apr 15;11(4):355-60 [7785336] Genes Dev. 1995 Jul 15;9(14):1781-96 [7542616] Mol Cell Biol. 1995 Nov;15(11):6351-63 [7565788] Biochem Biophys Res Commun. 1996 Mar 27;220(3):843-7 [8607853] Mol Cell Biol. 1996 Nov;16(11):6603-16 [8887689] EMBO J. 1996 Nov 15;15(22):6311-20 [8947054] Mol Cell Biol. 1997 Mar;17(3):1298-313 [9032257] J Biol Chem. 1997 May 9;272(19):12359-65 [9139680] Mol Cell Biol. 1997 Jul;17(7):4146-58 [9199350] Yeast. 1997 Jun 15;13(7):647-53 [9200814] Genes Dev. 1998 Feb 15;12(4):514-26 [9472020] J Biol Chem. 1998 May 22;273(21):12841-5 [9582312] Yeast. 1998 Jul;14(10):953-61 [9717241] EMBO J. 1999 Mar 15;18(6):1673-88 [10075937] Mol Cell Biol. 2005 Apr;25(8):3063-75 [15798194] Annu Rev Microbiol. 2005;59:407-50 [16153175] Cell. 2005 Sep 23;122(6):887-900 [16179258] Mol Cell Biol. 2006 Feb;26(4):1355-72 [16449648] J Mol Biol. 2007 Jul 6;370(2):315-30 [17512538] Mol Cell Biol. 2007 Jul;27(14):5225-34 [17526738] Mol Cell Biol. 2008 Nov;28(22):6877-88 [18794367] J Mol Biol. 2009 Sep 25;392(3):701-22 [19616556] Genetics. 1990 Nov;126(3):549-62 [2249755] Mol Cell Biol. 1991 Jun;11(6):3203-16 [2038326] Mol Cell Biol. 1991 Jun;11(6):3217-28 [2038327] Curr Top Cell Regul. 1992;32:243-369 [1318183] Mol Cell Biol. 1992 Dec;12(12):5801-15 [1448107] Mol Cell Biol. 2000 Jun;20(11):3965-76 [10805739] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/MCB.00265-10 ER - TY - JOUR T1 - Clarifying carcinogenicity of ethylbenzene. AN - 757465202; 20723573 AB - Ethylbenzene has been evaluated for carcinogenic activity in Fischer rats and B6C3F1 mice exposed by inhalation (Chan et al., 1998; Chan, 1999) and in Sprague-Dawley rats after oral exposure (Maltoni et al., 1985,1997). Bioassay findings are summarized below to expand on those not stated clearly or completely in Saghir et al. (2010). Overall in these three studies animals exposed to ethylbenzene had increased tumors in rats for kidneys, testes, head (including rare neuroesthesioepitheliomas), and total malignant tumors, whilst in mice tumor incidences were increased in the lung and liver (Huff, 2002). Thus ethylbenzene was carcinogenic by two exposure routes to both sexes of two species of rodents, two strains of rats, and one strain of mice, causing collectively tumors in five different target organs and a composite of "total malignant" tumors. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Huff, James AU - Chan, Po AU - Melnick, Ronald AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. huff1@niehs.nih.gov Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 167 EP - 9; discussion 170-2 VL - 58 IS - 2 KW - Benzene Derivatives KW - 0 KW - Carcinogens KW - ethylbenzene KW - L5I45M5G0O KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Humans KW - Carcinogenicity Tests -- methods KW - Mice KW - Species Specificity KW - Benzene Derivatives -- toxicity KW - Neoplasms -- pathology KW - Neoplasms -- chemically induced KW - Neoplasms -- epidemiology KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/757465202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Clarifying+carcinogenicity+of+ethylbenzene.&rft.au=Huff%2C+James%3BChan%2C+Po%3BMelnick%2C+Ronald&rft.aulast=Huff&rft.aufirst=James&rft.date=2010-11-01&rft.volume=58&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2010.08.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-19 N1 - Date created - 2010-10-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann N Y Acad Sci. 1999;895:56-79 [10676409] Occup Environ Med. 2010 Oct;67(10):720 [20837652] IARC Monogr Eval Carcinog Risks Hum. 2000;77:227-66 [11100403] FASEB J. 2001 Jan;15(1):195-203 [11149907] Mutat Res. 2000 Apr;462(2-3):407-21 [11523541] Ann N Y Acad Sci. 2002 Dec;982:198-207 [12562638] Ann N Y Acad Sci. 2002 Dec;982:208-30 [12562639] Am J Ind Med. 1985;7(5-6):415-46 [4003403] Environ Mutagen. 1985;7(4):427-8 [4054069] Carcinogenesis. 1988 Nov;9(11):2045-52 [3052903] Science. 1991 Jan 25;251(4992):387-8 [1989073] Cancer Lett. 1991 May 1;57(2):95-101 [1851054] Mol Carcinog. 1992;5(1):2-3 [1543538] FASEB J. 1992 Jun;6(9):2698-706 [1612294] IARC Sci Publ. 1992;(116):437-75 [1428093] Mol Carcinog. 1993;7(3):135-8 [8489710] Toxicol Ind Health. 1993 May-Jun;9(3):415-38 [8367884] Environ Health Perspect. 1993 Dec;101 Suppl 5:125-35 [8013399] Environ Health Perspect. 1993 Dec;101 Suppl 5:149-51 [8013403] Environ Health Perspect. 1993 Dec;101 Suppl 5:45-53 [8013424] Am J Ind Med. 1995 Feb;27(2):293-300 [7755018] Cancer Res. 1995 Sep 1;55(17):3759-62 [7641190] Environ Health Perspect. 1995 Jul-Aug;103(7-8):680-3 [7588478] Environ Health Perspect. 1996 Mar;104 Suppl 1:123-34 [8722116] Mod Pathol. 1996 Jun;9(6):606 [8782195] Carcinogenesis. 1997 Jan;18(1):97-105 [9054595] Toxicol Appl Pharmacol. 1998 Jan;148(1):137-47 [9465273] Ann N Y Acad Sci. 1997 Dec 26;837:15-52 [9472329] Toxicol Lett. 1998 Sep 30;99(1):23-32 [9801027] Regul Toxicol Pharmacol. 2010 Jul-Aug;57(2-3):129-35 [20096743] Comment On: Regul Toxicol Pharmacol. 2010 Jul-Aug;57(2-3):129-35 [20096743] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.yrtph.2010.08.011 ER - TY - JOUR T1 - An IGF1/insulin receptor substrate-1 pathway stimulates a mitotic kinase (cdk1) in the uterine epithelium during the proliferative response to estradiol. AN - 757460459; 20798132 AB - Estrogens are potent mitogens for some target organs, such as the uterus, and cancers that develop in this organ might be linked to the proliferative action of these hormones. However, the mechanism by which estrogens influence the cell cycle machinery is not known. We found that a null mutation for the insulin receptor substrate (IRS)-1, a docking protein that is important for IGF1 signaling, compromised hormone-induced mitosis in the uterine epithelium; BrdU incorporation was not affected. This selective effect on mitosis was associated with a reduction in uterine cyclin B-associated kinase activity; cyclin A-associated kinase activity was not changed. The null mutation also reduced the extent of hormone-induced phosphorylation of endogenous uterine histone H1, as determined with phospho-specific antiserum. Uterine epithelial cyclin dependent kinase (cdk)1 was induced in response to hormone, but the level of the kinase protein, as determined by immunoblotting, was noticeably less in the irs1 null mutant than that in the wild-type (WT) mouse, especially around the time of peak mitosis (24 h). Since IRS-1 binds/activates phosphatidylinositol 3-kinase (PI3K), the absence of this docking protein could impair signaling of a known pathway downstream of AKT that stimulates translation of cell cycle components. Indeed, we found that phosphorylation of uterine AKT (Ser473) in irs1 null mutants was less than that in WTs following treatment. Based on earlier studies, it is also possible that an IGF1/IRS-1/PI3K/AKT pathway regulates posttranslational changes in cdk1. This model may provide insights as to how a growth factor pathway can mediate hormone action on cell proliferation. JF - The Journal of endocrinology AU - Walker, Michael P AU - Diaugustine, Richard P AU - Zeringue, Ernest AU - Bunger, Maureen K AU - Schmitt, Martina AU - Archer, Trevor K AU - Richards, R Gregg AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Mail Drop D4-01, PO Box 12233, Research Triangle Park, North Carolina 27709, USA. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 225 EP - 235 VL - 207 IS - 2 KW - Insulin Receptor Substrate Proteins KW - 0 KW - Irs1 protein, mouse KW - insulin-like growth factor-1, mouse KW - Estradiol KW - 4TI98Z838E KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - CDC2 Protein Kinase KW - EC 2.7.11.22 KW - Index Medicus KW - Proto-Oncogene Proteins c-akt -- genetics KW - Cell Proliferation -- drug effects KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Animals KW - Epithelium -- physiology KW - Mice KW - Gene Expression Regulation -- drug effects KW - Female KW - Epithelium -- drug effects KW - Mice, Knockout KW - Insulin-Like Growth Factor I -- genetics KW - Uterus -- cytology KW - CDC2 Protein Kinase -- genetics KW - CDC2 Protein Kinase -- metabolism KW - Estradiol -- pharmacology KW - Insulin-Like Growth Factor I -- metabolism KW - Uterus -- enzymology KW - Insulin Receptor Substrate Proteins -- metabolism KW - Uterus -- drug effects KW - Insulin Receptor Substrate Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/757460459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+endocrinology&rft.atitle=An+IGF1%2Finsulin+receptor+substrate-1+pathway+stimulates+a+mitotic+kinase+%28cdk1%29+in+the+uterine+epithelium+during+the+proliferative+response+to+estradiol.&rft.au=Walker%2C+Michael+P%3BDiaugustine%2C+Richard+P%3BZeringue%2C+Ernest%3BBunger%2C+Maureen+K%3BSchmitt%2C+Martina%3BArcher%2C+Trevor+K%3BRichards%2C+R+Gregg&rft.aulast=Walker&rft.aufirst=Michael&rft.date=2010-11-01&rft.volume=207&rft.issue=2&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+endocrinology&rft.issn=1479-6805&rft_id=info:doi/10.1677%2FJOE-10-0102 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-16 N1 - Date created - 2010-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1677/JOE-10-0102 ER - TY - JOUR T1 - Neuropeptide Y has a protective role during murine retrovirus-induced neurological disease. AN - 757177937; 20702619 AB - Viral infections in the central nervous system (CNS) can lead to neurological disease either directly by infection of neurons or indirectly through activation of glial cells and production of neurotoxic molecules. Understanding the effects of virus-mediated insults on neuronal responses and neurotrophic support is important in elucidating the underlying mechanisms of viral diseases of the CNS. In the current study, we examined the expression of neurotrophin- and neurotransmitter-related genes during infection of mice with neurovirulent polytropic retrovirus. In this model, virus-induced neuropathogenesis is indirect, as the virus predominantly infects macrophages and microglia and does not productively infect neurons or astrocytes. Virus infection is associated with glial cell activation and the production of proinflammatory cytokines in the CNS. In the current study, we identified increased expression of neuropeptide Y (NPY), a pleiotropic growth factor which can regulate both immune cells and neuronal cells, as a correlate with neurovirulent virus infection. Increased levels of Npy mRNA were consistently associated with neurological disease in multiple strains of mice and were induced only by neurovirulent, not avirulent, virus infection. NPY protein expression was primarily detected in neurons near areas of virus-infected cells. Interestingly, mice deficient in NPY developed neurological disease at a faster rate than wild-type mice, indicating a protective role for NPY. Analysis of NPY-deficient mice indicated that NPY may have multiple mechanisms by which it influences virus-induced neurological disease, including regulating the entry of virus-infected cells into the CNS. JF - Journal of virology AU - Du, Min AU - Butchi, Niranjan B AU - Woods, Tyson AU - Morgan, Timothy W AU - Peterson, Karin E AD - Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 S. 4th St., Hamilton, MT 59840, USA. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 11076 EP - 11088 VL - 84 IS - 21 KW - Neuropeptide Y KW - 0 KW - Protective Agents KW - RNA, Messenger KW - Index Medicus KW - Animals KW - Neurons -- chemistry KW - RNA, Messenger -- analysis KW - Mice KW - Gene Expression Regulation KW - Neurons -- virology KW - Nervous System Diseases -- virology KW - Retroviridae KW - Neuropeptide Y -- analysis KW - Neuropeptide Y -- physiology KW - Neuropeptide Y -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/757177937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Neuropeptide+Y+has+a+protective+role+during+murine+retrovirus-induced+neurological+disease.&rft.au=Du%2C+Min%3BButchi%2C+Niranjan+B%3BWoods%2C+Tyson%3BMorgan%2C+Timothy+W%3BPeterson%2C+Karin+E&rft.aulast=Du&rft.aufirst=Min&rft.date=2010-11-01&rft.volume=84&rft.issue=21&rft.spage=11076&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.01022-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-04 N1 - Date created - 2010-10-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Pathol. 2006 Sep;169(3):1026-38 [16936275] Epilepsia. 2006 Apr;47(4):773-80 [16650144] Eur J Neurosci. 2007 Feb;25(4):1136-43 [17331209] J Virol. 2007 Nov;81(21):12040-8 [17715237] J Gen Virol. 2007 Dec;88(Pt 12):3373-84 [18024907] Neurosci Bull. 2008 Jun;24(3):155-9 [18500388] J Virol. 2008 Sep;82(17):8906-10 [18579597] J Immunol. 2009 Feb 15;182(4):2297-304 [19201884] J Exp Med. 2009 Nov 23;206(12):2735-45 [19901080] Rev Neurol (Paris). 2009 Dec;165(12):1039-44 [19906390] J Gen Virol. 2010 Apr;91(Pt 4):1028-37 [20007359] J Neurovirol. 2008 Nov;14(6):492-502 [19016073] Neurosci Lett. 2003 Apr 3;340(1):9-12 [12648746] J Virol. 2004 Jun;78(12):6449-58 [15163738] Neurosci Lett. 2004 Aug 12;366(2):197-200 [15276246] J Biol Chem. 2004 Aug 6;279(32):33782-90 [15178688] J Neuropathol Exp Neurol. 1974 Apr;33(2):285-307 [4362701] J Virol. 1990 Apr;64(4):1648-56 [2181155] J Neurosci. 1992 Sep;12(9):3361-71 [1527583] Cell Mol Neurobiol. 1993 Oct;13(5):541-6 [8111825] J Neuroimmunol. 1994 Apr;51(1):53-61 [8157736] J Virol. 1995 Dec;69(12):8070-5 [7494324] Nature. 1996 May 30;381(6581):415-21 [8632796] Methods Mol Biol. 2000;132:365-86 [10547847] J Neurol Sci. 1996 Mar;136(1-2):154-8 [8815163] J Virol. 1996 Jul;70(7):4825-8 [8676516] J Virol. 1997 Jul;71(7):5287-94 [9188597] Nat Med. 1997 Jul;3(7):761-4 [9212103] J Neurosci. 1997 Dec 1;17(23):8927-36 [9364040] Brain Pathol. 1999 Jan;9(1):21-31 [9989447] J Cereb Blood Flow Metab. 1999 Feb;19(2):155-63 [10027771] Horm Metab Res. 1999 May;31(5):330-4 [10422730] J Virol. 2004 Dec;78(23):13104-12 [15542662] Regul Pept. 2005 Jan 15;124(1-3):163-72 [15544855] Glia. 2005 Nov 1;52(2):153-62 [15920723] Neurobiol Dis. 2005 Dec;20(3):760-72 [15979311] Curr Top Microbiol Immunol. 2006;303:67-95 [16570857] Cell Death Differ. 2007 Feb;14(2):296-305 [16841089] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.01022-10 ER - TY - JOUR T1 - Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunction. AN - 756664408; 20713077 AB - Water soluble fullerenes, such as the hydroxylated fullerene, fullerenol (C₆₀OHx), are currently under development for diagnostic and therapeutic biomedical applications in the field of nanotechnology. These molecules have been shown to undergo urinary clearance, yet there is limited data available on their renal biocompatibility. Here we examine the biological responses of renal proximal tubule cells (LLC-PK1) exposed to fullerenol. Fullerenol was found to be cytotoxic in the millimolar range, with viability assessed by the sulforhodamine B and trypan blue assays. Fullerenol-induced cell death was associated with cytoskeleton disruption and autophagic vacuole accumulation. Interaction with the autophagy pathway was evaluated in vitro by Lysotracker Red dye uptake, LC3-II marker expression and TEM. Fullerenol treatment also resulted in coincident loss of cellular mitochondrial membrane potential and ATP depletion, as measured by the Mitotracker Red dye and the luciferin-luciferase assays, respectively. Fullerenol-induced ATP depletion and loss of mitochondrial potential were partially ameliorated by co-treatment with the autophagy inhibitor, 3-methyladenine. In vitro fullerenol treatment did not result in appreciable oxidative stress, as measured by lipid peroxide and glutathione content. Based on these data, it is hypothesized that cytoskeleton disruption may be an initiating event in fullerenol cytotoxicity, leading to subsequent autophagy dysfunction and loss of mitochondrial capacity. As nanoparticle-induced cytoskeleton disruption, autophagic vacuole accumulation and mitochondrial dysfunction are commonly reported in the literature, the proposed mechanism may be relevant for a variety of nanomaterials. Copyright © 2010 Elsevier Inc. All rights reserved. JF - Toxicology and applied pharmacology AU - Johnson-Lyles, Denise N AU - Peifley, Kimberly AU - Lockett, Stephen AU - Neun, Barry W AU - Hansen, Matthew AU - Clogston, Jeffrey AU - Stern, Stephan T AU - McNeil, Scott E AD - Nanotechnology Characterization Lab (NCL), Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, USA. Y1 - 2010/11/01/ PY - 2010 DA - 2010 Nov 01 SP - 249 EP - 258 VL - 248 IS - 3 KW - Cytotoxins KW - 0 KW - Fullerenes KW - fullerenol KW - 182024-42-6 KW - Index Medicus KW - Swine KW - Animals KW - Cytotoxins -- toxicity KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - LLC-PK1 Cells KW - Cell Survival -- physiology KW - Autophagy -- drug effects KW - Kidney -- metabolism KW - Kidney -- pathology KW - Cytoskeleton -- metabolism KW - Vacuoles -- pathology KW - Mitochondria -- pathology KW - Kidney -- drug effects KW - Fullerenes -- toxicity KW - Autophagy -- physiology KW - Cytoskeleton -- drug effects KW - Vacuoles -- drug effects KW - Mitochondria -- drug effects KW - Cytoskeleton -- pathology KW - Mitochondria -- metabolism KW - Vacuoles -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756664408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Fullerenol+cytotoxicity+in+kidney+cells+is+associated+with+cytoskeleton+disruption%2C+autophagic+vacuole+accumulation%2C+and+mitochondrial+dysfunction.&rft.au=Johnson-Lyles%2C+Denise+N%3BPeifley%2C+Kimberly%3BLockett%2C+Stephen%3BNeun%2C+Barry+W%3BHansen%2C+Matthew%3BClogston%2C+Jeffrey%3BStern%2C+Stephan+T%3BMcNeil%2C+Scott+E&rft.aulast=Johnson-Lyles&rft.aufirst=Denise&rft.date=2010-11-01&rft.volume=248&rft.issue=3&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2010.08.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-25 N1 - Date created - 2010-10-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biomed Pharmacother. 2005 Aug;59(7):351-8 [16087310] Nanomedicine. 2010 Jun;6(3):427-41 [20056170] Traffic. 2006 Feb;7(2):129-45 [16420522] Invest Radiol. 2006 Mar;41(3):332-8 [16481917] Anal Bioanal Chem. 2006 May;385(1):105-13 [16547740] Am J Physiol Cell Physiol. 2006 Jun;290(6):C1495-502 [16407415] Biochim Biophys Acta. 2006 May-Jun;1757(5-6):692-9 [16729962] Toxicol In Vitro. 2006 Oct;20(7):1202-12 [16697548] Autophagy. 2006 Jan-Mar;2(1):39-46 [16874071] Nano Lett. 2006 Aug;6(8):1794-807 [16895376] J Biol Chem. 2006 Nov 24;281(47):36303-16 [16963441] Autophagy. 2007 May-Jun;3(3):181-206 [17224625] Autophagy. 2007 Jul-Aug;3(4):337-46 [17404498] Eur J Pharmacol. 2007 Jul 30;568(1-3):89-98 [17560995] J Med Chem. 1999 Nov 4;42(22):4614-20 [10579823] J Biol Chem. 2000 Jan 14;275(2):992-8 [10625637] Free Radic Biol Med. 2000 Jul 1;29(1):26-33 [10962202] Nucl Med Biol. 2002 Aug;29(6):707-10 [12234597] J Cell Biol. 2004 Mar 15;164(6):803-9 [15024029] J Biol Chem. 2004 Apr 30;279(18):18614-22 [14985362] Cell Biol Int. 2004;28(8-9):615-23 [15350596] Toxicol Appl Pharmacol. 1993 May;120(1):72-9 [8511784] Am J Physiol. 1996 Oct;271(4 Pt 2):F790-8 [8898008] Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9434-9 [9256500] Toxicol Lett. 1997 Sep 19;93(1):29-37 [9381480] Chem Biol. 1995 Jun;2(6):385-9 [9383440] Environ Health Perspect. 1998 Apr;106 Suppl 2:559-69 [9599703] In Vitro Cell Dev Biol. 1989 Sep;25(9):800-5 [2793779] Annu Rev Pharmacol Toxicol. 1992;32:449-70 [1605574] Eur J Neurosci. 2007 Nov;26(10):2979-88 [18001292] Toxicol Sci. 2008 Jan;101(1):4-21 [17602205] Nanomedicine (Lond). 2007 Dec;2(6):789-803 [18095846] Technol Cancer Res Treat. 2008 Feb;7(1):15-25 [18198920] Biochem Biophys Res Commun. 2008 Mar 14;367(3):616-22 [18190792] Nanomedicine (Lond). 2008 Apr;3(2):201-13 [18373426] Mol Biol Cell. 2008 May;19(5):1962-75 [18287533] Int J Nanomedicine. 2008;3(1):59-68 [18488416] Biomaterials. 2008 Aug-Sep;29(24-25):3451-60 [18501960] Nat Nanotechnol. 2007 Dec;2(12):751-60 [18654426] Circ Res. 2008 Aug 15;103(4):343-51 [18703786] Toxicol Sci. 2008 Nov;106(1):140-52 [18632727] Pharmacol Rep. 2008 Sep-Oct;60(5):742-9 [19066422] Biomaterials. 2009 Feb;30(6):1184-96 [19046599] Toxicol Appl Pharmacol. 2009 Jan 15;234(2):222-35 [18983864] Toxicol Appl Pharmacol. 2009 May 1;236(3):319-28 [19268679] Autophagy. 2009 Jul;5(5):706-8 [19377297] Clin J Am Soc Nephrol. 2009 Jul;4(7):1275-83 [19520747] Eur J Clin Pharmacol. 2009 Aug;65(8):757-73 [19543887] ACS Nano. 2009 Sep 22;3(9):2505-14 [19681636] Autophagy. 2009 Nov;5(8):1107-17 [19786831] EMBO J. 2010 Mar 3;29(5):969-80 [20075865] Toxicology. 2010 Mar 10;269(2-3):155-9 [19941929] J Neurochem. 2010 Apr;113(1):275-84 [20405578] Nano Lett. 2005 Dec;5(12):2578-85 [16351219] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2010.08.008 ER - TY - JOUR T1 - A Yin-Yang balancing act of the lin28/let-7 link in tumorigenesis. AN - 756661051; 20739081 JF - Journal of hepatology AU - Ji, Junfang AU - Wang, Xin Wei AD - Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4258, USA. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 974 EP - 975 VL - 53 IS - 5 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756661051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hepatology&rft.atitle=A+Yin-Yang+balancing+act+of+the+lin28%2Flet-7+link+in+tumorigenesis.&rft.au=Ji%2C+Junfang%3BWang%2C+Xin+Wei&rft.aulast=Ji&rft.aufirst=Junfang&rft.date=2010-11-01&rft.volume=53&rft.issue=5&rft.spage=974&rft.isbn=&rft.btitle=&rft.title=Journal+of+hepatology&rft.issn=1600-0641&rft_id=info:doi/10.1016%2Fj.jhep.2010.07.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-01 N1 - Date created - 2010-10-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Nat Genet. 2009 Jul;41(7):843-8 [19483683] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jhep.2010.07.001 ER - TY - CONF T1 - 5th International PCB Workshop--summary and implications. AN - 756661010; 20728937 AB - A summation of new and novel findings presented at "The Fifth PCB Workshop: New Knowledge Gained from Old Pollutants" workshop is provided in this overview, along with discussion of data gaps and research needs in the future. Relative to the previous workshop, the scientific presentations had a decreased emphasis on toxicology; rather, more than half of the sessions dealt with environmental sources, fate and transport, or transformations. Approximately 100 presentations in the form of talks and posters were included in the workshop. The presentations were generally divided into: emissions and transport of PCBs in natural and urban settings; chiral aspects of PCB transport; metabolism and distribution; new aspects of environmental metabolism of PCBs--from microbes to plants to animals; reproduction, developmental and cardiovascular effects of PCBs; updates on Anniston--the most highly exposed PCB community in the U.S. to date; and new and novel approaches for evaluating PCB mixtures (e.g., PCB toxic equivalency factors, and TEFs)--and the implications of such for risk assessment. An overarching state-of-the-science view is important to the goal of preventing negative health consequences. Currently, there are still many roadblocks to evaluating risk associated with this large group of 209 congeners--all of which have different physiochemical properties, variable fate and transport mechanism in the environment, and a range of ability for persistence, bioaccumulation, and biological activity. Copyright © 2010 Elsevier Ltd. All rights reserved. JF - Environment international AU - Birnbaum, L S AU - Staskal-Wikoff, D S Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 814 EP - 818 VL - 36 IS - 8 KW - Mutagens KW - 0 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Animals KW - Biotransformation KW - Humans KW - Plants KW - Polychlorinated Biphenyls -- toxicity KW - Mutagens -- metabolism KW - Ecotoxicology -- trends KW - Polychlorinated Biphenyls -- metabolism KW - Mutagens -- toxicity KW - Environmental Exposure -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756661010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Environment+international&rft.atitle=5th+International+PCB+Workshop--summary+and+implications.&rft.au=Birnbaum%2C+L+S%3BStaskal-Wikoff%2C+D+S&rft.aulast=Birnbaum&rft.aufirst=L&rft.date=2010-11-01&rft.volume=36&rft.issue=8&rft.spage=814&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2010.06.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-11 N1 - Date created - 2010-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.envint.2010.06.011 ER - TY - JOUR T1 - On the future development of optimally-sized lipid-insoluble systemic therapies for CNS solid tumors and other neuropathologies. AN - 756299707; 20722627 AB - It remains a challenge to deliver effective concentrations of therapeutics into CNS pathologies, which is primarily due to the fact that current and investigational CNS therapeutics are suboptimally-sized to accumulate to effective concentrations in individual diseased CNS tissue cells. The blood-CNS barrier of blood capillary microvasculature within neuropathologic tissues is known to be permeable to lipid-insoluble macromolecules in a wide-spectrum of neuropathologies. In the case of CNS solid tumor tissue blood capillaries, the physiological upper limit of pore size to the transcapillary passage of spherical lipid-insoluble macromolecules is approximately 12 nanometers, and systemically administered imageable dendrimer nanoparticles within the 7 to 10 nanometer size range accumulate to therapeutic concentrations in solid tumors since this size range of particles maintain peak blood concentrations for several hours. In preliminary pre-clinical studies, it has recently been shown that one intravenous dose of small molecule chemotherapy-conjugated imageable dendrimer nanoparticles within the 7 to 10 nanometer size range, with doxorubicin bound to the particle exterior via acid-labile covalent linkages, is effective at regressing orthotopic rodent malignant gliomas. Although it is foreseeable that such drug-conjugated imageable nanoparticles within the 7 to 10 nanometer size range will be effective theranostic agents for the concurrent treatment (i.e. neutron capture therapy) and imaging (i.e. magnetic resonance) of solid tumor disease, the issue of maintaining a neutralized particle exterior following the attachment of cationic drugs will need to be addressed to eliminate cationic charge-mediated nanoparticle toxicity to blood capillary walls. In this review, the ultrastructural basis for blood capillary microvascular permeability to lipid-insoluble macromolecules is discussed, and the importance of delineating the precise physiologic upper limits of pore size in the blood capillary microvasculature of other CNS pathologies, including neurodegenerative, inflammatory and ischemic CNS diseases, is emphasized. The discussion herein will serve as guide for the future development of optimally-sized, non-toxic and non-immunogenic lipid-insoluble systemic therapies, which should be the focus of future patent applications and patents on CNS drug development. JF - Recent patents on CNS drug discovery AU - Sarin, Hemant AD - National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA. hemantsarin74@gmail.com Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 239 EP - 252 VL - 5 IS - 3 KW - Antineoplastic Agents KW - 0 KW - Central Nervous System Agents KW - Index Medicus KW - Hydrophobic and Hydrophilic Interactions KW - Drug Delivery Systems KW - Animals KW - Technology, Pharmaceutical KW - Solubility KW - Particle Size KW - Humans KW - Capillary Permeability KW - Molecular Conformation KW - Nanotechnology KW - Central Nervous System Neoplasms -- blood supply KW - Antineoplastic Agents -- pharmacokinetics KW - Central Nervous System Neoplasms -- drug therapy KW - Blood-Brain Barrier -- physiology KW - Central Nervous System Diseases -- drug therapy KW - Central Nervous System Agents -- chemistry KW - Antineoplastic Agents -- chemistry KW - Drug Design KW - Blood-Brain Barrier -- physiopathology KW - Central Nervous System Agents -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756299707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Recent+patents+on+CNS+drug+discovery&rft.atitle=On+the+future+development+of+optimally-sized+lipid-insoluble+systemic+therapies+for+CNS+solid+tumors+and+other+neuropathologies.&rft.au=Sarin%2C+Hemant&rft.aulast=Sarin&rft.aufirst=Hemant&rft.date=2010-11-01&rft.volume=5&rft.issue=3&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Recent+patents+on+CNS+drug+discovery&rft.issn=2212-3954&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-31 N1 - Date created - 2010-09-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Up-regulation of erythropoietin receptor by nitric oxide mediates hypoxia preconditioning. AN - 755162511; 20806411 AB - Erythropoietin (Epo), known to stimulate erythroid progenitor cell survival, proliferation, and differentiation, has been shown to be neuroprotective against brain ischemia in animal models. Both Epo and Epo receptor (EpoR) are expressed in the brain and are up-regulated by hypoxia. Brain Epo signaling can stimulate neural cell survival and prevent neuron apoptosis. Neurons from EpoR null mice exhibit marked increased sensitivity to hypoxia. In endothelial cells, Epo has been shown to stimulate nitric oxide (NO) production, particularly at low pO(2). We found here that the EpoR expression on neural cells and Epo's neuroprotective effect were regulated by NO. Hypoxia increased NO production as well as EpoR expression, and inhibition of NOS activity reduced the proportion of EpoR-expressing neurons induced at low pO(2). Conversely, addition of NO donor to cultures grown under normoxia induced EpoR. Similarly, NO donor increased EpoR promoter activity in a reporter gene assay, suggesting that NO regulates EpoR at the transcription level. Preincubation of neurons with NO results in induction of EpoR, which gives rise to protection against hypoxia even in the absence of exogenous Epo, although at high concentration NO is toxic. These data provide evidence of a role for NO in Epo activity in brain and suggest links between NO production, EpoR expression, and Epo signaling in neuroprotection. JF - Journal of neuroscience research AU - Chen, Zhi-Yong AU - Wang, Li AU - Asavaritkrai, Pundit AU - Noguchi, Constance Tom AD - Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1822, USA. Y1 - 2010/11/01/ PY - 2010 DA - 2010 Nov 01 SP - 3180 EP - 3188 VL - 88 IS - 14 KW - Receptors, Erythropoietin KW - 0 KW - Recombinant Proteins KW - Erythropoietin KW - 11096-26-7 KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Animals KW - Neurons -- metabolism KW - Neurons -- drug effects KW - Mice KW - Cytoprotection -- drug effects KW - Mice, Transgenic KW - Mice, Knockout KW - Up-Regulation -- physiology KW - Signal Transduction -- physiology KW - Gene Expression Regulation -- physiology KW - Cells, Cultured KW - Up-Regulation -- drug effects KW - Signal Transduction -- drug effects KW - Mice, Inbred C57BL KW - Gene Expression Regulation -- drug effects KW - Cytoprotection -- physiology KW - Hypoxia-Ischemia, Brain -- physiopathology KW - Receptors, Erythropoietin -- biosynthesis KW - Receptors, Erythropoietin -- genetics KW - Hypoxia-Ischemia, Brain -- genetics KW - Nitric Oxide -- physiology KW - Hypoxia-Ischemia, Brain -- metabolism KW - Ischemic Preconditioning -- methods KW - Erythropoietin -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755162511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroscience+research&rft.atitle=Up-regulation+of+erythropoietin+receptor+by+nitric+oxide+mediates+hypoxia+preconditioning.&rft.au=Chen%2C+Zhi-Yong%3BWang%2C+Li%3BAsavaritkrai%2C+Pundit%3BNoguchi%2C+Constance+Tom&rft.aulast=Chen&rft.aufirst=Zhi-Yong&rft.date=2010-11-01&rft.volume=88&rft.issue=14&rft.spage=3180&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroscience+research&rft.issn=1097-4547&rft_id=info:doi/10.1002%2Fjnr.22473 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-24 N1 - Date created - 2010-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jnr.22473 ER - TY - JOUR T1 - Organochlorine pesticides and endometriosis. AN - 754004795; 20580667 AB - Limited study of persistent organochlorine pesticides (OCPs) and endometriosis has been conducted. One hundred women aged 18-40 years who were undergoing laparoscopy provided 20 cm(3) of blood for toxicologic analysis and surgeons completed operative reports regarding the presence of endometriosis. Gas chromatography with electron capture was used to quantify (ng/g serum) six OCPs. Logistic regression was utilized to estimate the adjusted odds ratios (aOR) and 95% confidence intervals (CI) for individual pesticides and groups based on chemical structure adjusting for current cigarette smoking and lipids. The highest tertile of aromatic fungicide was associated with a fivefold risk of endometriosis (aOR=5.3; 95% CI, 1.2-23.6) compared to the lowest tertile. Similar results were found for t-nonachlor and HCB. These are the first such findings in a laproscopic cohort that suggest an association between OCP exposure and endometriosis. More prospective studies are necessary to ensure temporal ordering and confirm these findings. Copyright © 2010 Elsevier Inc. All rights reserved. JF - Reproductive toxicology (Elmsford, N.Y.) AU - Cooney, Maureen A AU - Buck Louis, Germaine M AU - Hediger, Mary L AU - Vexler, Albert AU - Kostyniak, Paul J AD - Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health & Human Development, 6100 Executive Blvd, Rockville, MD 20852, USA. cooneyma@mail.nih.gov Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 365 EP - 369 VL - 30 IS - 3 KW - Hydrocarbons, Chlorinated KW - 0 KW - Pesticides KW - Index Medicus KW - Severity of Illness Index KW - Young Adult KW - Chromatography, Gas KW - Logistic Models KW - Laparoscopy KW - Humans KW - Cohort Studies KW - Adult KW - Surveys and Questionnaires KW - Adolescent KW - Female KW - Endometriosis -- blood KW - Hydrocarbons, Chlorinated -- toxicity KW - Endometriosis -- chemically induced KW - Hydrocarbons, Chlorinated -- blood KW - Endometriosis -- diagnosis KW - Pesticides -- toxicity KW - Pesticides -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754004795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=Organochlorine+pesticides+and+endometriosis.&rft.au=Cooney%2C+Maureen+A%3BBuck+Louis%2C+Germaine+M%3BHediger%2C+Mary+L%3BVexler%2C+Albert%3BKostyniak%2C+Paul+J&rft.aulast=Cooney&rft.aufirst=Maureen&rft.date=2010-11-01&rft.volume=30&rft.issue=3&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=1873-1708&rft_id=info:doi/10.1016%2Fj.reprotox.2010.05.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-11 N1 - Date created - 2010-09-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Fertil Steril. 1998 Feb;69(2):221-8 [9496332] Fertil Steril. 1997 May;67(5):817-21 [9130884] Hum Reprod. 2005 Jan;20(1):279-85 [15513976] Environ Health Perspect. 2005 Jul;113(7):853-7 [16002372] Environ Res. 2005 Sep;99(1):118-25 [15927178] Fertil Steril. 2005 Aug;84(2):305-12 [16084869] Am J Epidemiol. 2005 Sep 15;162(6):523-32 [16093292] Fertil Steril. 2005 Nov;84(5):1366-74 [16275231] Am J Epidemiol. 2006 Feb 15;163(4):374-83 [16394206] Fertil Steril. 2006 Mar;85(3):775-9 [16500362] Chemosphere. 2006 May;63(8):1361-7 [16289286] Hum Reprod. 2007 Dec;22(12):3232-6 [17956923] Hum Reprod. 2009 Feb;24(2):451-8 [18940895] Chemosphere. 2009 Feb;74(7):944-9 [19027927] Environ Health Perspect. 2009 Jul;117(7):1070-5 [19654915] Arch Environ Contam Toxicol. 1999 May;36(4):498-503 [10227871] Stat Med. 2001 Jan 15;20(1):33-45 [11135346] Am J Epidemiol. 2003 Feb 15;157(4):355-63 [12578806] Hum Reprod. 2003 Jul;18(7):1512-5 [12832380] Environ Res. 2003 Jun;92(2):110-7 [12854690] Fertil Steril. 2004 Aug;82(2):314-21 [15302277] Fertil Steril. 1982 Dec;38(6):667-72 [6216124] Fertil Steril. 1985 Mar;43(3):351-2 [3979573] Arch Environ Contam Toxicol. 1989 Jul-Aug;18(4):495-500 [2505694] Hum Reprod. 1991 Apr;6(4):544-9 [1918305] Hum Reprod. 1991 May;6(5):699-702 [1939552] Zentralbl Gynakol. 1992;114(12):593-602 [1285483] Baillieres Clin Obstet Gynaecol. 1993 Dec;7(4):673-85 [8131309] J Am Assoc Gynecol Laparosc. 1994 Nov;2(1):43-7 [9050532] Hum Reprod. 1997 Feb;12(2):373-5 [9070728] Erratum In: Reprod Toxicol. 2011 Jul;32(1):145 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.reprotox.2010.05.011 ER - TY - JOUR T1 - Accelerated wound healing mediated by activation of Toll-like receptor 9 AN - 1780505509; 14098246 AB - ABSTRACTWound healing is mediated through complex interactions between circulating immune cells and local epithelial and endothelial cells. Elements of the innate immune system are triggered when Toll-like receptors (TLR) are stimulated by their cognate ligands, and previous studies suggest that such interactions can accelerate wound healing. This work examines the effect of treating excisional skin biopsies with immunostimulatory CpG oligodeoxynucleotides (ODN) that trigger via TLR9. Results indicate that CpG (but not control) ODN accelerate wound closure and reduce the total wound area exposed over time by >40% (p<0.01). TLR9 knockout mice, a strain unresponsive to the immunomodulatory effects of CpG stimulation, are unresponsive to ODN treatment and exhibit a general delay in healing when compared with wild-type mice. CpG ODN administration promoted the influx of macrophages to the wound site and increased the production of vascular endothelial growth factor, expediting neovascularization of the wound bed (p<0.01 for both parameters). Stimulation via TLR9 thus represents a novel strategy to accelerate wound healing. JF - Wound Repair and Regeneration AU - Sato, Takashi AU - Yamamoto, Masaki AU - Shimosato, Takeshi AU - Klinman, Dennis M AD - 1. Cancer and Inflammation Program, National Cancer Institute, Frederick, Maryland Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 586 EP - 593 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 18 IS - 6 SN - 1067-1927, 1067-1927 KW - Biotechnology and Bioengineering Abstracts KW - Macrophages KW - Vascular endothelial growth factor KW - Skin KW - vascularization KW - Immune system KW - TLR9 protein KW - Wound healing KW - Biopsy KW - CpG islands KW - Oligonucleotides KW - Immunomodulation KW - Endothelial cells KW - Immunostimulation KW - Toll-like receptors KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780505509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wound+Repair+and+Regeneration&rft.atitle=Accelerated+wound+healing+mediated+by+activation+of+Toll-like+receptor+9&rft.au=Sato%2C+Takashi%3BYamamoto%2C+Masaki%3BShimosato%2C+Takeshi%3BKlinman%2C+Dennis+M&rft.aulast=Sato&rft.aufirst=Takashi&rft.date=2010-11-01&rft.volume=18&rft.issue=6&rft.spage=586&rft.isbn=&rft.btitle=&rft.title=Wound+Repair+and+Regeneration&rft.issn=10671927&rft_id=info:doi/10.1111%2Fj.1524-475X.2010.00632.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Vascular endothelial growth factor; Macrophages; Skin; vascularization; TLR9 protein; Immune system; Wound healing; Biopsy; CpG islands; Immunomodulation; Oligonucleotides; Endothelial cells; Immunostimulation; Toll-like receptors DO - http://dx.doi.org/10.1111/j.1524-475X.2010.00632.x ER - TY - JOUR T1 - Gene Expression Alterations in Immune System Pathways in the Thymus after Exposure to Immunosuppressive Chemicals AN - 1677912485; 14606808 AB - Dysregulation of positive and negative selection, antigen presentation, or apoptosis in the thymus can lead to immunosuppression or autoimmunity. Diethylstilbestrol (DES), dexamethasone (DEX), cyclophosphamide (CPS), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are immunosuppressive chemicals that induce similar immunotoxic effects in the thymus, however, the mechanism of toxicity is purported to be different for each compound. We hypothesized that genomic analysis of thymus after chemical-induced atrophy would yield transcriptional profiles that suggest pathways of toxicity associated with reduced function. Female B6C3F1 mice were exposed to these immunosuppressive agents and changes in gene expression and immune cell subpopulations were evaluated. All four chemicals induced thymic atrophy and changes in both the relative proportion and absolute number of CD3+, CD4+/CD8a, CD4a/CD8+, and CD4+/CD8+ thymocytes. The most significant impact of exposure to DEX, DES, and CPS was modulation of gene expression in the T-cell receptor (TCR) complex and TCR and CD28 signaling pathways; this could represent a common mechanism of action and play a pivotal role in lineage commitment and development of T cells. Up-regulation of genes associated with the antigen presentation and dendritic cell maturation pathways was the most distinctive effect of TCDD exposure. These elements, which were also up-regulated by DEX and DES, contribute to positive and negative selection. Genomic analysis revealed gene expression changes in several pathways that are commonly associated with xenobiotic-induced immune system perturbations, particularly those that contribute to the development and maturation of thymic T cells. JF - Environmental Health Perspectives AU - Frawley, Rachel AU - White, Kimber AU - Brown, Ronnetta AU - Musgrove, Deborah AU - Walker, Nigel AU - Germolec, Dori AD - National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina, USA Y1 - 2010/11/01/ PY - 2010 DA - 2010 Nov 01 SP - 371 EP - 376 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 119 IS - 3 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - cyclophosphamide KW - dexamethasone KW - diethylstilbestrol KW - T cell KW - thymus KW - toxicogenomics KW - 2,3,7,8-tetrachlorodibenzo-p-dioxin KW - Gene expression KW - Maturation KW - Immune systems KW - Antigens KW - Pathways KW - Modulation KW - Mice KW - Atrophy KW - Toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677912485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Gene+Expression+Alterations+in+Immune+System+Pathways+in+the+Thymus+after+Exposure+to+Immunosuppressive+Chemicals&rft.au=Frawley%2C+Rachel%3BWhite%2C+Kimber%3BBrown%2C+Ronnetta%3BMusgrove%2C+Deborah%3BWalker%2C+Nigel%3BGermolec%2C+Dori&rft.aulast=Frawley&rft.aufirst=Rachel&rft.date=2010-11-01&rft.volume=119&rft.issue=3&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002358 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1289/ehp.1002358 ER - TY - JOUR T1 - Cigarette Smoke Induces C/EBP- beta -Mediated Activation of miR-31 in Normal Human Respiratory Epithelia and Lung Cancer Cells AN - 954602872; 14026104 AB - Limited information is available regarding mechanisms by which miRNAs contribute to pulmonary carcinogenesis. The present study was undertaken to examine expression and function of miRNAs induced by cigarette smoke condensate (CSC) in normal human respiratory epithelia and lung cancer cells. Micro-array and quantitative RT-PCR (qRT-PCR) techniques were used to assess miRNA and host gene expression in cultured cells, and surgical specimens. Software-guided analysis, RNA cross-link immunoprecipitation (CLIP), 3' UTR luciferase reporter assays, qRT-PCR, focused super-arrays and western blot techniques were used to identify and confirm targets of miR-31. Chromatin immunoprecipitation (ChIP) techniques were used to evaluate histone marks and transcription factors within the LOC554202 promoter. Cell count and xenograft experiments were used to assess effects of miR-31 on proliferation and tumorigenicity of lung cancer cells. CSC significantly increased miR-31 expression and activated LOC554202 in normal respiratory epithelia and lung cancer cells; miR-31 and LOC554202 expression persisted following discontinuation of CSC exposure. miR-31 and LOC554202 expression levels were significantly elevated in lung cancer specimens relative to adjacent normal lung tissues. CLIP and reporter assays demonstrated direct interaction of miR-31 with Dickkopf-1 (Dkk-1) and DACT-3. Over-expression of miR-31 markedly diminished Dkk-1 and DACT3 expression levels in normal respiratory epithelia and lung cancer cells. Knock-down of miR-31 increased Dkk-1 and DACT3 levels, and abrogated CSC-mediated decreases in Dkk-1 and DACT-3 expression. Furthermore, over-expression of miR-31 diminished SFRP1, SFRP4, and WIF-1, and increased Wnt-5a expression. CSC increased H3K4Me3, H3K9/14Ac and C/EBP- beta levels within the LOC554202 promoter. Knock-down of C/EBP- beta abrogated CSC-mediated activation of LOC554202. Over-expression of miR-31 significantly enhanced proliferation and tumorigenicity of lung cancer cells; knock-down of miR-31 inhibited growth of these cells. Cigarette smoke induces expression of miR-31 targeting several antagonists of cancer stem cell signaling in normal respiratory epithelia and lung cancer cells. miR-31 functions as an oncomir during human pulmonary carcinogenesis. JF - PLoS ONE AU - Xi, Sichuan AU - Yang, Maocheng AU - Tao, Yongguang AU - Xu, Hong AU - Shan, Jigui AU - Inchauste, Suzanne AU - Zhang, Mary AU - Mercedes, Leandro AU - Hong, Julie A AU - Rao, Mahadev AU - Schrump, David S AD - Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America Y1 - 2010/10/29/ PY - 2010 DA - 2010 Oct 29 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - 0 KW - Toxicology Abstracts KW - Western blotting KW - Histones KW - Chromatin KW - miRNA KW - Immunoprecipitation KW - Tumorigenicity KW - Cigarette smoke KW - Antagonists KW - Gene expression KW - Promoters KW - Stem cells KW - Condensates KW - RNA KW - Frizzled-related protein 1 KW - Overexpression KW - Transcription factors KW - Carcinogenesis KW - Polymerase chain reaction KW - Dkk1 protein KW - Xenografts KW - Cell proliferation KW - Lung cancer KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954602872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Cigarette+Smoke+Induces+C%2FEBP-+beta+-Mediated+Activation+of+miR-31+in+Normal+Human+Respiratory+Epithelia+and+Lung+Cancer+Cells&rft.au=Xi%2C+Sichuan%3BYang%2C+Maocheng%3BTao%2C+Yongguang%3BXu%2C+Hong%3BShan%2C+Jigui%3BInchauste%2C+Suzanne%3BZhang%2C+Mary%3BMercedes%2C+Leandro%3BHong%2C+Julie+A%3BRao%2C+Mahadev%3BSchrump%2C+David+S&rft.aulast=Xi&rft.aufirst=Sichuan&rft.date=2010-10-29&rft.volume=5&rft.issue=0&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0013764 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-07-24 N1 - SubjectsTermNotLitGenreText - Western blotting; Histones; Chromatin; miRNA; Immunoprecipitation; Tumorigenicity; Cigarette smoke; Antagonists; Gene expression; Promoters; Stem cells; Condensates; RNA; Frizzled-related protein 1; Transcription factors; Overexpression; Carcinogenesis; Polymerase chain reaction; Dkk1 protein; Xenografts; Cell proliferation; Lung cancer DO - http://dx.doi.org/10.1371/journal.pone.0013764 ER - TY - JOUR T1 - Serum cytokine concentrations, flavonol intake and colorectal adenoma recurrence in the Polyp Prevention Trial AN - 954609884; 14163750 AB - Background:Serum cytokine concentrations may reflect inflammatory processes occurring during the development of colorectal neoplasms. Flavonols, bioactive compounds found in plant-based foods and beverages, may inhibit colorectal neoplasms partly by attenuating inflammation. Methods:Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to investigate the association between serum concentrations of interleukin (IL)1 beta , 2, 8, 10, 12p70, granulocyte macrophage colony stimulating factor, interferon- gamma , and tumour necrosis factor- alpha , measured over time, flavonol intake, estimated from a flavonol database used in conjunction with a food frequency questionnaire, and adenoma recurrence in 872 participants from the intervention arm of the Polyp Prevention Trial. Results:Decreased IL-2 concentration during the trial increased the risk of any adenoma recurrence (4th vs 1st quartile, OR=1.68, 95% CI=1.13-2.49), whereas decreased IL-1 beta or IL-10 reduced the risk of advanced adenoma recurrence (OR=0.37, 95% CI=0.15-0.94; OR=0.39, 95% CI=0.15-0.98, respectively). Individuals with flavonol intake above the median (29.7mg per day) and decreased cytokine concentrations had the lowest risk of advanced adenoma recurrence. Conclusion:Overall, no consistent associations were observed between serum cytokine profile and colorectal adenoma recurrence; however, decreased cytokine concentrations during high flavonol consumption may indicate prevention of colorectal neoplasms. JF - British Journal of Cancer AU - Bobe, G AU - Murphy, G AU - Albert, P S AU - Sansbury, L B AU - Lanza, E AU - Schatzkin, A AU - Colburn, N H AU - Cross, A J AD - Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Building 576, Room 101, 1050 Boyles Street, Frederick, MD 21702, USA Y1 - 2010/10/26/ PY - 2010 DA - 2010 Oct 26 SP - 1453 EP - 1461 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 103 IS - 9 SN - 0007-0920, 0007-0920 KW - Immunology Abstracts; Risk Abstracts KW - Inventories KW - gamma -Interferon KW - Beverages KW - Interleukin 2 KW - Food KW - Interleukin 1 KW - Granulocyte-macrophage colony-stimulating factor KW - Colorectal cancer KW - Polyps KW - Flavonols KW - Food plants KW - Cancer KW - Interleukin 10 KW - Inflammation KW - Databases KW - intervention KW - Risk factors KW - prevention KW - Cytokines KW - bioactive compounds KW - Tumor necrosis factor- alpha KW - Adenoma KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954609884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Serum+cytokine+concentrations%2C+flavonol+intake+and+colorectal+adenoma+recurrence+in+the+Polyp+Prevention+Trial&rft.au=Bobe%2C+G%3BMurphy%2C+G%3BAlbert%2C+P+S%3BSansbury%2C+L+B%3BLanza%2C+E%3BSchatzkin%2C+A%3BColburn%2C+N+H%3BCross%2C+A+J&rft.aulast=Bobe&rft.aufirst=G&rft.date=2010-10-26&rft.volume=103&rft.issue=9&rft.spage=1453&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605915 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Inventories; Beverages; Interleukin 2; Food; Interleukin 1; Colorectal cancer; Granulocyte-macrophage colony-stimulating factor; Flavonols; Polyps; Food plants; Interleukin 10; Inflammation; Databases; Risk factors; Cytokines; Tumor necrosis factor- alpha; Adenoma; intervention; prevention; bioactive compounds; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6605915 ER - TY - JOUR T1 - Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and alpha DEC-CSP in non human primates AN - 867741381; 14778429 AB - Development of a fully effective vaccine against the pre-erythrocytic stage of malaria infection will likely require induction of both humoral and cellular immune responses. Protein based vaccines can elicit such broad-based immunity depending on the adjuvant and how the protein is formulated. Here to assess these variables, non human primates (NHP) were immunized three times with Plasmodium falciparum (Pf) circumsporozoite protein (CSP) or CSP cloned into MG38, a monoclonal antibody that targets DEC-205 ( alpha DEC-CSP), an endocytic receptor on dendritic cells (DCs). Both vaccines were administered with or without poly(I:C) as adjuvant. Following three immunizations, the magnitude and quality of cytokine secreting CD4+ T cells were comparable between CSP + poly(I:C) and alpha DEC-CSP + poly(I:C) groups with both regimens eliciting multi-functional cytokine responses. However, NHP immunized with CSP + poly(I:C) had significantly higher serum titers of CSP-specific IgG antibodies and indirect immunofluorescent antibody (IFA) titers against Pf sporozoites. Furthermore, sera from both CSP or alpha DEC-CSP + poly(I:C) immunized animals limited sporozoite invasion of a hepatocyte cell line (HC04) in vitro. To determine whether CSP-specific responses could be enhanced, all NHP primed with CSP or alpha DEC-CSP + poly(I:C) were boosted with a single dose of 150,000 irradiated Pf sporozoites (PfSPZ) intravenously. Remarkably, boosting had no effect on the CSP-specific immunity. Finally, immunization with CSP + poly-ICLC reduced malaria parasite burden in the liver in an experimental mouse model. Taken together, these data showing that poly(I:C) is an effective adjuvant for inducing potent antibody and Th1 immunity with CSP based vaccines offers a potential alternative to the existing protein based pre-erythrocytic vaccines. JF - Vaccine AU - Tewari, Kavita AU - Flynn, Barbara J AU - Boscardin, Silvia B AU - Kastenmueller, Kathrin AU - Salazar, Andres M AU - Anderson, Charles A AU - Soundarapandian, Velmurugan AU - Ahumada, Adriana AU - Keler, Tibor AU - Hoffman, Stephen L AU - Nussenzweig, Michel C AU - Steinman, Ralph M AU - Seder, Robert A AD - Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, United States, rseder@mail.nih.gov rseder@mail.nih.gov rseder@mail.nih.gov rseder@mail.nih.gov Y1 - 2010/10/21/ PY - 2010 DA - 2010 Oct 21 SP - 7256 EP - 7266 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 28 IS - 45 SN - 0264-410X, 0264-410X KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Pre-erythrocytic vaccines KW - Poly(I:C) KW - Circumsporozoite protein (CSP) KW - Parasites KW - Human diseases KW - Hepatocytes KW - Helper cells KW - Animal models KW - Disease control KW - Malaria KW - Adjuvants KW - Infection KW - Public health KW - circumsporozoite protein KW - Dendritic cells KW - CD4 antigen KW - Lymphocytes T KW - Cytokines KW - Immune response (humoral) KW - Data processing KW - Monoclonal antibodies KW - Sporozoites KW - Plasmodium falciparum KW - Immunity KW - Immunization KW - Antibodies KW - Immunoglobulin G KW - Liver KW - Vaccines KW - K 03350:Immunology KW - F 06905:Vaccines KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867741381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Poly%28I%3AC%29+is+an+effective+adjuvant+for+antibody+and+multi-functional+CD4%2B+T+cell+responses+to+Plasmodium+falciparum+circumsporozoite+protein+%28CSP%29+and+alpha+DEC-CSP+in+non+human+primates&rft.au=Tewari%2C+Kavita%3BFlynn%2C+Barbara+J%3BBoscardin%2C+Silvia+B%3BKastenmueller%2C+Kathrin%3BSalazar%2C+Andres+M%3BAnderson%2C+Charles+A%3BSoundarapandian%2C+Velmurugan%3BAhumada%2C+Adriana%3BKeler%2C+Tibor%3BHoffman%2C+Stephen+L%3BNussenzweig%2C+Michel+C%3BSteinman%2C+Ralph+M%3BSeder%2C+Robert+A&rft.aulast=Tewari&rft.aufirst=Kavita&rft.date=2010-10-21&rft.volume=28&rft.issue=45&rft.spage=7256&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2010.08.098 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Antibodies; Disease control; Malaria; Immunity; Vaccines; Public health; Data processing; Monoclonal antibodies; Hepatocytes; Helper cells; Animal models; Sporozoites; Adjuvants; Infection; Immunization; circumsporozoite protein; Dendritic cells; CD4 antigen; Liver; Immunoglobulin G; Lymphocytes T; Cytokines; Immune response (humoral); Plasmodium falciparum DO - http://dx.doi.org/10.1016/j.vaccine.2010.08.098 ER - TY - JOUR T1 - Improved Estimates of Cancer-Specific Survival Rates From Population-Based Data AN - 954600754; 14087040 AB - Background Accurate estimates of cancer survival are important for assessing optimal patient care and prognosis. Evaluation of these estimates via relative survival (a ratio of observed and expected survival rates) requires a population life table that is matched to the cancer population by age, sex, race and/or ethnicity, socioeconomic status, and ideally risk factors for the cancer under examination. Because life tables for all subgroups in a study may be unavailable, we investigated whether cause-specific survival could be used as an alternative for relative survival. Methods We used data from the Surveillance, Epidemiology, and End Results Program for 2330905 cancer patients from January 1, 1992, through December 31, 2004. We defined cancer-specific deaths according to the following variables: cause of death, only one tumor or the first of multiple tumors, site of the original cancer diagnosis, and comorbidities. Estimates of relative survival and cause-specific survival that were derived by use of an actuarial method were compared. Results Among breast cancer patients who were white, black, or of Asian or Pacific Islander descent and who were older than 65 years, estimates of 5-year relative survival (107.5%, 106.6%, and 103.0%, respectively) were higher than estimates of 5-year cause-specific survival (98.6%, 95% confidence interval [CI] = 98.4% to 98.8%; 97.4%, 95% CI = 96.2% to 98.2%; and 99.2%, 95% CI = 98.4%, 99.6%, respectively). Relative survival methods likely underestimated rates for cancers of the oral cavity and pharynx (eg, for white cancer patients aged greater than or equal to 65 years, relative survival = 54.2%, 95% CI = 53.1% to 55.3%, and cause-specific survival = 60.1%, 95% CI = 59.1% to 60.9%) and the lung and bronchus (eg, for black cancer patients aged greater than or equal to 65 years, relative survival = 10.5%, 95% CI = 9.9% to 11.2%, and cause-specific survival = 11.9%, 95% CI = 11.2 % to 12.6%), largely because of mismatches between the population with these diseases and the population used to derive the life table. Socioeconomic differences between groups with low and high status in relative survival estimates appeared to be inflated (eg, corpus and uterus socioeconomic status gradient was 13.3% by relative survival methods and 8.8% by cause-specific survival methods). Conclusion Although accuracy of the cause of death on a death certificate can be problematic for cause-specific survival estimates, cause-specific survival methods may be an alternative to relative survival methods when suitable life tables are not available. JF - Journal of the National Cancer Institute AU - Howlader, Nadia AU - Ries, Lynn AG AU - Mariotto, Angela B AU - Reichman, Marsha E AU - Ruhl, Jennifer AU - Cronin, Kathleen A AD - Affiliation of authors: Division of Cancer Control and Population Sciences, Surveillance Research Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, howladern@mail.nih.gov Y1 - 2010/10/20/ PY - 2010 DA - 2010 Oct 20 SP - 1584 EP - 1598 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 20 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Mortality KW - Socioeconomics KW - tumors KW - Cancer KW - Morbidity KW - Lung KW - I, Pacific KW - Breast cancer KW - survival KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954600754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Improved+Estimates+of+Cancer-Specific+Survival+Rates+From+Population-Based+Data&rft.au=Howlader%2C+Nadia%3BRies%2C+Lynn+AG%3BMariotto%2C+Angela+B%3BReichman%2C+Marsha+E%3BRuhl%2C+Jennifer%3BCronin%2C+Kathleen+A&rft.aulast=Howlader&rft.aufirst=Nadia&rft.date=2010-10-20&rft.volume=102&rft.issue=20&rft.spage=1584&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjq366 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; Lung; Socioeconomics; Breast cancer; tumors; survival; Ethnic groups; Morbidity; Cancer; I, Pacific DO - http://dx.doi.org/10.1093/jnci/djq366 ER - TY - JOUR T1 - Universal and specific quantitative detection of botulinum neurotoxin genes AN - 954592185; 14024430 AB - Clostridium botulinum, an obligate anaerobic spore-forming bacterium, produces seven antigenic variants of botulinum toxin that are distinguished serologically and termed "serotypes". Botulinum toxin blocks the release of acetylcholine at neuromuscular junctions resulting in flaccid paralysis. The potential lethality of the disease warrants a fast and accurate means of diagnosing suspected instances of food contamination or human intoxication. Currently, the Food and Drug Administration (FDA)-accepted assay to detect and type botulinum neurotoxins (BoNTs) is the mouse protection bioassay. While specific and sensitive, this assay requires the use of laboratory animals, may take up to four days to achieve a diagnosis, and is unsuitable for high-throughput analysis. We report here a two-step PCR assay that identifies all toxin types, that achieves the specificity of the mouse bioassay while surpassing it in equivalent sensitivity, that has capability for high-throughput analysis, and that provides quantitative results within hours. The first step of our assay consists of a conventional PCR that detects the presence of C. botulinum regardless of the neurotoxin type. The second step uses quantitative PCR (qPCR) technology to determine the specific serotype of the neurotoxin. We assayed purified C. botulinum DNA and crude toxin preparations, as well as food and stool from healthy individuals spiked with purified BoNT DNA, and one stool sample from a case of infant botulism for the presence of the NTNH gene, which is part of the BoNT gene cluster, and for the presence of serotype-specific BoNT genes. The PCR surpassed the mouse bioassay both in specificity and sensitivity, detecting positive signals in BoNT preparations containing well below the 1 LD50 required for detection via the mouse bioassay. These results were type-specific and we were reliably able to quantify as few as 10 genomic copies. While other studies have reported conventional or quantitative PCR-based assays for the detection of C. botulinum genes, our procedure's high-throughput capability and its portability allows most laboratories to quickly assess the possible presence of BoNTs either in food processing samples or in suspected cases of botulism. Thus, this assay provides rapid and specific detection of BoNT and toxin complex genes and would enable the targeting of appropriate therapeutics to infected individuals in a timely manner. JF - BMC Microbiology AU - Hill, Brenna J AU - Skerry, Janet C AU - Smith, Theresa J AU - Arnon, Stephen S AU - Douek, Daniel C AD - Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 USA Y1 - 2010/10/20/ PY - 2010 DA - 2010 Oct 20 SP - 267 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 10 KW - Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Toxicology Abstracts; CSA Neurosciences Abstracts KW - Intoxication KW - Food processing KW - Antigenic variants KW - Serotypes KW - Botulism KW - Laboratory animals KW - Clostridium botulinum KW - Food contamination KW - Paralysis KW - Lethality KW - Neuromuscular junctions KW - Polymerase chain reaction KW - Acetylcholine KW - genomics KW - Botulinum toxin KW - Feces KW - Neurotoxins KW - Infants KW - N3 11023:Neurogenetics KW - X 24320:Food Additives & Contaminants KW - A 01330:Food Microbiology KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954592185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Microbiology&rft.atitle=Universal+and+specific+quantitative+detection+of+botulinum+neurotoxin+genes&rft.au=Hill%2C+Brenna+J%3BSkerry%2C+Janet+C%3BSmith%2C+Theresa+J%3BArnon%2C+Stephen+S%3BDouek%2C+Daniel+C&rft.aulast=Hill&rft.aufirst=Brenna&rft.date=2010-10-20&rft.volume=10&rft.issue=&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=BMC+Microbiology&rft.issn=1471-2180&rft_id=info:doi/10.1186%2F1471-2180-10-267 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Food processing; Intoxication; Antigenic variants; Serotypes; Botulism; Laboratory animals; Food contamination; Paralysis; Lethality; Neuromuscular junctions; Polymerase chain reaction; Acetylcholine; Botulinum toxin; genomics; Neurotoxins; Feces; Infants; Clostridium botulinum DO - http://dx.doi.org/10.1186/1471-2180-10-267 ER - TY - JOUR T1 - Association of MC1R Variants and Host Phenotypes With Melanoma Risk in CDKN2A Mutation Carriers: A GenoMEL Study AN - 876236317; 14087049 AB - Background Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A mutations is modified by pigmentation characteristics, nevus phenotypes, and some variants of the melanocortin-1 receptor gene (MC1R), which is known to have a role in the pigmentation process. However, investigation of the associations of both MC1R variants and host phenotypes with melanoma risk has been limited. Methods We included 815 CDKN2A mutation carriers (473 affected, and 342 unaffected, with melanoma) from 186 families from 15 centers in Europe, North America, and Australia who participated in the Melanoma Genetics Consortium. In this family-based study, we assessed the associations of the four most frequent MC1R variants (V60L, V92M, R151C, and R160W) and the number of variants (1, greater than or equal to 2 variants), alone or jointly with the host phenotypes (hair color, propensity to sunburn, and number of nevi), with melanoma risk in CDKN2A mutation carriers. These associations were estimated and tested using generalized estimating equations. All statistical tests were two-sided. Results Carrying any one of the four most frequent MC1R variants (V60L, V92M, R151C, R160W) in CDKN2A mutation carriers was associated with a statistically significantly increased risk for melanoma across all continents (1.24 10 super(-6) less than or equal to P less than or equal to .0007). A consistent pattern of increase in melanoma risk was also associated with increase in number of MC1R variants. The risk of melanoma associated with at least two MC1R variants was 2.6-fold higher than the risk associated with only one variant (odds ratio = 5.83 [95% confidence interval = 3.60 to 9.46] vs 2.25 [95% confidence interval = 1.44 to 3.52]; P sub(trend) = 1.86 10 super(-8)). The joint analysis of MC1R variants and host phenotypes showed statistically significant associations of melanoma risk, together with MC1R variants (.0001 less than or equal to P less than or equal to .04), hair color (.006 less than or equal to P less than or equal to .06), and number of nevi (6.9 10 super(-6) less than or equal to P less than or equal to .02). Conclusion Results show that MC1R variants, hair color, and number of nevi were jointly associated with melanoma risk in CDKN2A mutation carriers. This joint association may have important consequences for risk assessments in familial settings. JF - Journal of the National Cancer Institute AU - Demenais, F AU - Mohamdi, H AU - Chaudru, V AU - Goldstein, A M AU - Newton Bishop, JA AU - Bishop, D T AU - Kanetsky, P A AU - Hayward, N K AU - Gillanders, E AU - Elder, DE AU - Avril, M F AU - Azizi, E AU - van Belle, P AU - Bergman, W AU - Bianchi-Scarra, G AU - Bressac-de Paillerets, B AU - Calista, D AU - Carrera, C AU - Hansson, J AU - Harland, M AU - Hogg, D AU - Hoeiom, V AU - Holland, E A AU - Ingvar, C AU - Landi, M T AU - Lang, J M AU - Mackie, R M AU - Mann, G J AU - Ming, ME AU - Njauw, C J AU - Olsson, H AU - Palmer, J AU - Pastorino, L AU - Puig, S AU - Randerson-Moor, J AU - Stark, M AU - Tsao, H AU - Tucker, MA AU - van der Velden, P AU - Yang, X R AU - Gruis, N AD - Affiliations of authors: INSERM, U946, Fondation Jean-Dausset-CEPH, Paris, France (FD, HM, VC, BB-dP); Universite Paris Diderot, Paris 7, Institut Universitaire d'Hematologie, Paris, France (FD, HM); Fondation Jean Dausset-CEPH, Paris, France (FD, HM, VC); Universite d'Evry Val d'Essonne, Evry, France (VC); Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (AMG, MTL, MAT, XRY); Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital, Leeds, UK (JANB, DTB, MH, JR-M); Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology & Biostatistics, University of Pennsylvania, Philadelphia, PA (PAK); Oncogenomics Laboratory, Queensland Institute of Medical Research, Brisbane, Queens, florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr Y1 - 2010/10/20/ PY - 2010 DA - 2010 Oct 20 SP - 1568 EP - 1583 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 20 SN - 0027-8874, 0027-8874 KW - Genetics Abstracts; Toxicology Abstracts KW - Risk assessment KW - Pigmentation KW - cyclin-dependent kinase inhibitors KW - Mathematical models KW - Statistical analysis KW - Hair KW - alpha -Melanocyte-stimulating hormone KW - Melanoma KW - Color KW - Risk factors KW - Nevus KW - Mutation KW - X 24340:Cosmetics, Toiletries & Household Products KW - G 07880:Human Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876236317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Association+of+MC1R+Variants+and+Host+Phenotypes+With+Melanoma+Risk+in+CDKN2A+Mutation+Carriers%3A+A+GenoMEL+Study&rft.au=Demenais%2C+F%3BMohamdi%2C+H%3BChaudru%2C+V%3BGoldstein%2C+A+M%3BNewton+Bishop%2C+JA%3BBishop%2C+D+T%3BKanetsky%2C+P+A%3BHayward%2C+N+K%3BGillanders%2C+E%3BElder%2C+DE%3BAvril%2C+M+F%3BAzizi%2C+E%3Bvan+Belle%2C+P%3BBergman%2C+W%3BBianchi-Scarra%2C+G%3BBressac-de+Paillerets%2C+B%3BCalista%2C+D%3BCarrera%2C+C%3BHansson%2C+J%3BHarland%2C+M%3BHogg%2C+D%3BHoeiom%2C+V%3BHolland%2C+E+A%3BIngvar%2C+C%3BLandi%2C+M+T%3BLang%2C+J+M%3BMackie%2C+R+M%3BMann%2C+G+J%3BMing%2C+ME%3BNjauw%2C+C+J%3BOlsson%2C+H%3BPalmer%2C+J%3BPastorino%2C+L%3BPuig%2C+S%3BRanderson-Moor%2C+J%3BStark%2C+M%3BTsao%2C+H%3BTucker%2C+MA%3Bvan+der+Velden%2C+P%3BYang%2C+X+R%3BGruis%2C+N&rft.aulast=Demenais&rft.aufirst=F&rft.date=2010-10-20&rft.volume=102&rft.issue=20&rft.spage=1568&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjq363 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Risk assessment; Pigmentation; cyclin-dependent kinase inhibitors; Mathematical models; Risk factors; Statistical analysis; Nevus; alpha -Melanocyte-stimulating hormone; Hair; Mutation; Color; Melanoma DO - http://dx.doi.org/10.1093/jnci/djq363 ER - TY - JOUR T1 - Biodistribution and excretion of monosaccharide-albumin conjugates measured with in vivo near-infrared fluorescence imaging. AN - 759523450; 20853850 AB - Target specific small molecules as modulators of drug delivery may play a significant role in the future development of therapeutics. Small molecules can alter the in vivo pharmacokinetics of therapeutic macromolecules leading to more efficient drug delivery with less systemic toxicity. The potential of creating a more effective drug delivery system through glycosylation has led, for instance, to the addition of galactose to increase drug delivery to the liver. However, there are many other monosaccharides with potentially useful targeting properties that require further characterization. Here, we investigate the potential of glycosylation to guide molecular therapies using five different monosaccharides conjugated to human serum albumin (HSA). Additionally, we investigate how the amount of glycosylation may alter the pharmacokinetic profile of HSA. We introduce the use of in vivo near-infrared optical imaging to characterize the effect of differential glycosylation on the pharmacokinetics of macromolecules. JF - Bioconjugate chemistry AU - McCann, Thomas E AU - Kosaka, Nobuyuki AU - Mitsunaga, Makoto AU - Choyke, Peter L AU - Gildersleeve, Jeffrey C AU - Kobayashi, Hisataka AD - Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1088, USA. Y1 - 2010/10/20/ PY - 2010 DA - 2010 Oct 20 SP - 1925 EP - 1932 VL - 21 IS - 10 KW - Fluorescent Dyes KW - 0 KW - Monosaccharides KW - Serum Albumin KW - Index Medicus KW - Animals KW - Humans KW - Organ Specificity KW - Mice KW - Fluorescent Dyes -- chemistry KW - Female KW - Serum Albumin -- metabolism KW - Serum Albumin -- chemistry KW - Infrared Rays KW - Serum Albumin -- pharmacokinetics KW - Molecular Imaging -- methods KW - Monosaccharides -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759523450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+chemistry&rft.atitle=Biodistribution+and+excretion+of+monosaccharide-albumin+conjugates+measured+with+in+vivo+near-infrared+fluorescence+imaging.&rft.au=McCann%2C+Thomas+E%3BKosaka%2C+Nobuyuki%3BMitsunaga%2C+Makoto%3BChoyke%2C+Peter+L%3BGildersleeve%2C+Jeffrey+C%3BKobayashi%2C+Hisataka&rft.aulast=McCann&rft.aufirst=Thomas&rft.date=2010-10-20&rft.volume=21&rft.issue=10&rft.spage=1925&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+chemistry&rft.issn=1520-4812&rft_id=info:doi/10.1021%2Fbc100313p LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-31 N1 - Date created - 2010-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Annu Rev Biochem. 1982;51:531-54 [6287920] Cancer Sci. 2007 Nov;98(11):1727-33 [17784874] Eur J Immunol. 2008 Feb;38(2):424-36 [18200633] Bioconjug Chem. 2009 Jan;20(1):147-54 [19072537] J Control Release. 2008 Dec 18;132(3):171-83 [18582981] J Med Chem. 2010 Feb 25;53(4):1579-86 [20102220] Mol Imaging Biol. 2010 Dec;12(6):583-94 [20376568] J Biol Chem. 1986 Jun 5;261(16):7412-8 [3011783] J Biol Chem. 1986 Jun 5;261(16):7426-32 [3711094] Int J Rad Appl Instrum B. 1990;17(2):201-7 [1692819] Cancer Res. 1990 Nov 15;50(22):7376-81 [2224865] J Biol Chem. 1991 Feb 15;266(5):3343-8 [1993707] Int J Rad Appl Instrum B. 1991;18(7):663-6 [1787074] J Pharm Sci. 1999 Jun;88(6):577-85 [10350492] Int J Pharm. 2004 Dec 9;287(1-2):147-54 [15541921] Chembiochem. 2005 Dec;6(12):2229-41 [16252298] Angew Chem Int Ed Engl. 2006 May 26;45(22):3607-10 [16639753] Bioconjug Chem. 2006 Jul-Aug;17(4):958-66 [16848403] Biochem Biophys Res Commun. 2006 Sep 29;348(3):807-13 [16904640] J Biomed Opt. 2007 Sep-Oct;12(5):051501 [17994865] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/bc100313p ER - TY - JOUR T1 - Risk Factors for Cervical Precancer and Cancer in HIV-Infected, HPV-Positive Rwandan Women AN - 1014099245; 13966204 AB - Although cervical cancer is an AIDS-defining condition, infection with human immunodeficiency virus (HIV) may only modestly increase the risk of cervical cancer. There is a paucity of information regarding factors that influence the natural history of human papillomavirus (HPV) in HIV-infected women. We examined factors associated with cervical intraepithelial neoplasia grade 3 or cancer (CIN3+) in Rwandan women infected with both HIV and HPV (HIV+/HPV+). In 2005, 710 HIV+ Rwandan women .25 years enrolled in an observational cohort study; 476 (67%) tested HPV+. Each woman provided sociodemographic data, CD4 count, a cervical cytology specimen and cervicovaginal lavage (CVL), which was tested for >40 HPV genotypes by MY09/MY11 PCR assay. Logistic regression models calculated odds ratios (OR) and 95% confidence intervals (CI) of associations of potential risk factors for CIN3+ among HIV+/HPV+ women. Of the 476 HIV+/HPV+ women 42 (8.8%) were diagnosed with CIN3+. Factors associated with CIN3+ included .7 (vs. 0-2) pregnancies, malarial infection in the previous six months (vs. never), and .7 (vs. 0-2) lifetime sexual partners. Compared to women infected by non-HPV16 carcinogenic HPV genotypes, HPV16 infection was positively associated and non-carcinogenic HPV infection was inversely associated with CIN3+. CD4 count was significantly associated with CIN3+ only in analyses of women with non-HPV16 carcinogenic HPV (OR=0.62 per 100 cells/mm3, CI=0.40-0.97). In this HIV+/HPV+ population, lower CD4 was significantly associated with CIN3+ only in women infected with carcinogenic non-HPV16. We found a trend for higher risk of CIN3+ in HIV+ women reporting recent malarial infection; this association should be investigated in a larger group of HIV+/HPV+ women. JF - PLoS ONE AU - Anastos, Kathryn AU - Hoover, Donald R AU - Burk, Robert D AU - Cajigas, Antonio AU - Shi, Qiuhu AU - Singh, Diljeet K AU - Cohen, Mardge H AU - Mutimura, Eugene AU - Sturgis, Charles AU - Banzhaf, William C AU - Castle, Philip E AD - National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America Y1 - 2010/10/20/ PY - 2010 DA - 2010 Oct 20 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - 0 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Virology & AIDS Abstracts KW - Data processing KW - Nucleotide sequence KW - Cervical cancer KW - Women KW - Genotypes KW - Infection KW - Neoplasia KW - Risks KW - Pregnancy KW - Sexual partners KW - CD4 antigen KW - Human immunodeficiency virus KW - Human papillomavirus 16 KW - Risk factors KW - Regression analysis KW - DNA KW - Polymerase chain reaction KW - Cytology KW - Cervix KW - Human papillomavirus KW - V 22360:AIDS and HIV KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1014099245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Risk+Factors+for+Cervical+Precancer+and+Cancer+in+HIV-Infected%2C+HPV-Positive+Rwandan+Women&rft.au=Anastos%2C+Kathryn%3BHoover%2C+Donald+R%3BBurk%2C+Robert+D%3BCajigas%2C+Antonio%3BShi%2C+Qiuhu%3BSingh%2C+Diljeet+K%3BCohen%2C+Mardge+H%3BMutimura%2C+Eugene%3BSturgis%2C+Charles%3BBanzhaf%2C+William+C%3BCastle%2C+Philip+E&rft.aulast=Anastos&rft.aufirst=Kathryn&rft.date=2010-10-20&rft.volume=5&rft.issue=0&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0013525 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Nucleotide sequence; Women; DNA; Cytology; Polymerase chain reaction; Genotypes; Risks; Pregnancy; Sexual partners; CD4 antigen; Data processing; Risk factors; Cervical cancer; Regression analysis; Cervix; Infection; Neoplasia; Human immunodeficiency virus; Human papillomavirus 16; Human papillomavirus DO - http://dx.doi.org/10.1371/journal.pone.0013525 ER - TY - JOUR T1 - Maternal Alcohol Consumption, Alcohol Metabolism Genes, and the Risk of Oral Clefts: A Population-based Case-Control Study in Norway, 1996-2001 AN - 858422457; 14086482 AB - Heavy maternal alcohol consumption during early pregnancy increases the risk of oral clefts, but little is known about how genetic variation in alcohol metabolism affects this association. Variants in the alcohol dehydrogenase 1C (ADH1C) gene may modify the association between alcohol and clefts. In a population-based case-control study carried out in Norway (1996-2001), the authors examined the association between maternal alcohol consumption and risk of oral clefts according to mother and infant ADH1C haplotypes encoding fast or slow alcohol-metabolizing phenotypes. Subjects were 483 infants with oral cleft malformations and 503 control infants and their mothers, randomly selected from all other livebirths taking place during the same period. Mothers who consumed 5 or more alcoholic drinks per sitting during the first trimester of pregnancy had an elevated risk of oral cleft in their offspring (odds ratio (OR) = 2.6, 95% confidence interval (CI): 1.4, 4.7). This increased risk was evident only in mothers or children who carried the ADH1C haplotype associated with reduced alcohol metabolism (OR= 3.0, 95% CI: 1.4, 6.8). There was no evidence of alcohol-related risk when both mother and infant carried only the rapid-metabolism ADH1C variant (OR = 0.9, 95% CI: 0.2, 4.1). The teratogenic effect of alcohol may depend on the genetic capacity of the mother and fetus to metabolize alcohol. JF - American Journal of Epidemiology AU - Boyles, Abee L AU - DeRoo, Lisa A AU - Lie, Rolv T AU - Taylor, Jack A AU - Jugessur, Astanand AU - Murray, Jeffrey C AU - Wilcox, Allen J Y1 - 2010/10/15/ PY - 2010 DA - 2010 Oct 15 SP - 924 EP - 931 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 172 IS - 8 SN - 0002-9262, 0002-9262 KW - Genetics Abstracts; Toxicology Abstracts; Risk Abstracts KW - Alcohol KW - Beverages KW - Alcohol dehydrogenase KW - Genetic diversity KW - genetic diversity KW - haplotypes KW - Children KW - Alcoholics KW - Fetuses KW - Pregnancy KW - Haplotypes KW - Teratogenicity KW - Progeny KW - Norway KW - Metabolism KW - offspring KW - Infants KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/858422457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Maternal+Alcohol+Consumption%2C+Alcohol+Metabolism+Genes%2C+and+the+Risk+of+Oral+Clefts%3A+A+Population-based+Case-Control+Study+in+Norway%2C+1996-2001&rft.au=Boyles%2C+Abee+L%3BDeRoo%2C+Lisa+A%3BLie%2C+Rolv+T%3BTaylor%2C+Jack+A%3BJugessur%2C+Astanand%3BMurray%2C+Jeffrey+C%3BWilcox%2C+Allen+J&rft.aulast=Boyles&rft.aufirst=Abee&rft.date=2010-10-15&rft.volume=172&rft.issue=8&rft.spage=924&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwq226 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - Beverages; Alcohol dehydrogenase; Genetic diversity; Children; Fetuses; Alcoholics; Pregnancy; Haplotypes; Progeny; Teratogenicity; Metabolism; Ethanol; Infants; Alcohol; genetic diversity; haplotypes; offspring; Norway DO - http://dx.doi.org/10.1093/aje/kwq226 ER - TY - JOUR T1 - A parallel chiral-achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome AN - 856756788; 13946001 AB - A parallel chiral/achiral LC-MS/MS assay has been developed and validated to measure the plasma and urine concentrations of the enantiomers of ketamine, (R)- and (S)-Ket, in complex regional pain syndrome (CRPS) patients receiving a 5-day continuous infusion of a sub-anesthetic dose of (R,S)-Ket. The method was also validated for the determination of the enantiomers of the Ket metabolites norketamine, (R)- and (S)-norKet and dehydronorketamine, (R)- and (S)-DHNK, as well as the diastereomeric metabolites hydroxynorketamine, (2S,6S)-/(2R,6R)-HNK and two hydroxyketamines, (2S,6S)-HKet and (2S,6R)-Hket. In this method, (R,S)-Ket, (R,S)-norKet and (R,S)-DHNK and the diastereomeric hydroxyl-metabolites were separated and quantified using a C sub(18) stationary phase and the relative enantiomeric concentrations of (R,S)-Ket, (R,S)-norKet and (R,S)-DHNK were determined using an AGP-CSP. The analysis of the results of microsomal incubations of (R)- and (S)-Ket and a plasma and urine sample from a CRPS patient indicated the presence of 10 additional compounds and glucuronides. The data from the analysis of the patient sample also demonstrated that a series of HNK metabolites were the primary metabolites in plasma and (R)- and (S)-DHNK were the major metabolites found in urine. The results suggest that norKet is the initial, but not the primary metabolite and that downstream norKet metabolites play a role in (R,S)-Ket-related pain relief in CRPS patients. JF - Talanta AU - Moaddel, Ruin AU - Venkata, Swarajya Lakshmi Vattem AU - Tanga, Mary J AU - Bupp, James E AU - Green, Carol E AU - Iyer, Lalitha AU - Furimsky, Anna AU - Goldberg, Michael E AU - Torjman, Marc C AU - Wainer, Irving W AD - Laboratory for Clinical Investigation, National Institute on Aging/NIH, Baltimore, MD, United States, wainerir@grc.nia.nih.gov Y1 - 2010/10/15/ PY - 2010 DA - 2010 Oct 15 SP - 1892 EP - 1904 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 82 IS - 5 SN - 0039-9140, 0039-9140 KW - Toxicology Abstracts; Water Resources Abstracts; Aqualine Abstracts KW - Assay KW - Metabolites KW - AQ 00001:Water Resources and Supplies KW - SW 0540:Properties of water KW - X:24310 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856756788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Talanta&rft.atitle=A+parallel+chiral-achiral+liquid+chromatographic+method+for+the+determination+of+the+stereoisomers+of+ketamine+and+ketamine+metabolites+in+the+plasma+and+urine+of+patients+with+complex+regional+pain+syndrome&rft.au=Moaddel%2C+Ruin%3BVenkata%2C+Swarajya+Lakshmi+Vattem%3BTanga%2C+Mary+J%3BBupp%2C+James+E%3BGreen%2C+Carol+E%3BIyer%2C+Lalitha%3BFurimsky%2C+Anna%3BGoldberg%2C+Michael+E%3BTorjman%2C+Marc+C%3BWainer%2C+Irving+W&rft.aulast=Moaddel&rft.aufirst=Ruin&rft.date=2010-10-15&rft.volume=82&rft.issue=5&rft.spage=1892&rft.isbn=&rft.btitle=&rft.title=Talanta&rft.issn=00399140&rft_id=info:doi/10.1016%2Fj.talanta.2010.08.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Metabolites DO - http://dx.doi.org/10.1016/j.talanta.2010.08.005 ER - TY - JOUR T1 - Genome-wide analysis of novel splice variants induced by topoisomerase I poisoning shows preferential occurrence in genes encoding splicing factors. AN - 758836539; 20817775 AB - RNA splicing is required to remove introns from pre-mRNA, and alternative splicing generates protein diversity. Topoisomerase I (Top1) has been shown to be coupled with splicing by regulating serine/arginine-rich splicing proteins. Prior studies on isolated genes also showed that Top1 poisoning by camptothecin (CPT), which traps Top1 cleavage complexes (Top1cc), can alter RNA splicing. Here, we tested the effect of Top1 inhibition on splicing at the genome-wide level in human colon carcinoma HCT116 and breast carcinoma MCF7 cells. The RNA of HCT116 cells treated with CPT for various times was analyzed with ExonHit Human Splice Array. Unlike other exon array platforms, the ExonHit arrays include junction probes that allow the detection of splice variants with high sensitivity and specificity. We report that CPT treatment preferentially affects the splicing of splicing-related factors, such as RBM8A, and generates transcripts coding for inactive proteins lacking key functional domains. The splicing alterations induced by CPT are not observed with cisplatin or vinblastine and are not simply due to reduced Top1 activity, as Top1 downregulation by short interfering RNA did not alter splicing like CPT treatment. Inhibition of RNA polymerase II (Pol II) hyperphosphorylation by 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole (DRB) blocked the splicing alteration induced by CPT, which suggests that the rapid Pol II hyperphosphorylation induced by CPT interferes with normal splicing. The preferential effect of CPT on genes encoding splicing factors may explain the abnormal splicing of a large number of genes in response to Top1cc. ©2010 AACR. JF - Cancer research AU - Solier, Stéphanie AU - Barb, Jennifer AU - Zeeberg, Barry R AU - Varma, Sudhir AU - Ryan, Mike C AU - Kohn, Kurt W AU - Weinstein, John N AU - Munson, Peter J AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA. Y1 - 2010/10/15/ PY - 2010 DA - 2010 Oct 15 SP - 8055 EP - 8065 VL - 70 IS - 20 KW - Antineoplastic Agents, Phytogenic KW - 0 KW - DNA-Binding Proteins KW - RNA, Small Interfering KW - Vinblastine KW - 5V9KLZ54CY KW - RNA Polymerase II KW - EC 2.7.7.- KW - DNA Topoisomerases, Type I KW - EC 5.99.1.2 KW - Cisplatin KW - Q20Q21Q62J KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - Vinblastine -- pharmacology KW - RNA Polymerase II -- metabolism KW - Genetic Variation KW - Exons -- drug effects KW - Colonic Neoplasms -- genetics KW - Alternative Splicing -- drug effects KW - Alternative Splicing -- genetics KW - Camptothecin -- pharmacology KW - Humans KW - Antineoplastic Agents, Phytogenic -- pharmacology KW - DNA-Binding Proteins -- genetics KW - RNA, Small Interfering -- genetics KW - Models, Statistical KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Small Interfering -- drug effects KW - RNA Polymerase II -- drug effects KW - Exons -- genetics KW - RNA Splicing -- genetics KW - Phosphorylation KW - Colonic Neoplasms -- drug therapy KW - Cisplatin -- pharmacology KW - DNA-Binding Proteins -- drug effects KW - Down-Regulation -- drug effects KW - DNA Topoisomerases, Type I -- poisoning KW - Genome-Wide Association Study -- methods KW - DNA Topoisomerases, Type I -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758836539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Genome-wide+analysis+of+novel+splice+variants+induced+by+topoisomerase+I+poisoning+shows+preferential+occurrence+in+genes+encoding+splicing+factors.&rft.au=Solier%2C+St%C3%A9phanie%3BBarb%2C+Jennifer%3BZeeberg%2C+Barry+R%3BVarma%2C+Sudhir%3BRyan%2C+Mike+C%3BKohn%2C+Kurt+W%3BWeinstein%2C+John+N%3BMunson%2C+Peter+J%3BPommier%2C+Yves&rft.aulast=Solier&rft.aufirst=St%C3%A9phanie&rft.date=2010-10-15&rft.volume=70&rft.issue=20&rft.spage=8055&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-10-2491 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-23 N1 - Date created - 2010-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2003 Dec 1;63(23):8203-11 [14678976] J Biol Chem. 1985 Nov 25;260(27):14873-8 [2997227] Proc Natl Acad Sci U S A. 1987 Oct;84(20):7024-7 [2823250] Nature. 1993 Sep 16;365(6443):227-32 [8396729] Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11508-12 [8265582] Science. 1994 Jul 29;265(5172):615-21 [8036511] Nature. 1996 May 2;381(6577):80-2 [8609994] J Mol Med (Berl). 1997 Nov-Dec;75(11-12):786-800 [9428609] Mol Cell. 1999 Jun;3(6):697-705 [10394358] Med Sci (Paris). 2005 Mar;21(3):253-60 [15745698] Nucleic Acids Res. 2005;33(5):e47 [15760843] Biochem Biophys Res Commun. 2005 Jun 3;331(2):398-403 [15850773] BMC Bioinformatics. 2005;6:168 [15998470] J Mol Biol. 2006 Mar 17;357(1):127-38 [16427078] Prog Nucleic Acid Res Mol Biol. 2006;81:179-229 [16891172] Nat Struct Mol Biol. 2006 Sep;13(9):815-22 [16921380] Nat Rev Cancer. 2006 Oct;6(10):789-802 [16990856] Genes Dev. 2006 Nov 1;20(21):2922-36 [17079683] Nat Struct Mol Biol. 2006 Nov;13(11):973-80 [17028590] BMC Bioinformatics. 2007;8:75 [17338820] J Biol Chem. 2007 Aug 3;282(31):22544-50 [17562711] FEBS Lett. 2008 Jan 23;582(2):372-8 [18166155] Mol Cancer Ther. 2008 Jun;7(6):1398-409 [18566212] Nucleic Acids Res. 2008 Jul;36(12):4128-36 [18550580] J Biol Chem. 2008 Jul 18;283(29):19991-8 [18495665] J Mol Biol. 2008 Sep 5;381(3):540-9 [18588899] J Biol Chem. 2008 Aug 22;283(34):23200-8 [18556653] Biochim Biophys Acta. 2000 Jul 24;1492(2-3):465-9 [11004516] Genomics. 2000 Oct 1;69(1):54-62 [11013075] J Cell Biol. 2001 Jul 9;154(1):25-32 [11448987] Cancer Res. 2001 Sep 15;61(18):6876-84 [11559564] Nat Genet. 2002 Jan;30(1):13-9 [11753382] Annu Rev Biochem. 2001;70:369-413 [11395412] Nat Rev Mol Cell Biol. 2002 Jun;3(6):430-40 [12042765] J Mol Biol. 2002 Sep 27;322(4):677-86 [12270705] Mol Cell Biol. 2003 Apr;23(7):2341-50 [12640119] Genome Res. 2003 Aug;13(8):1863-72 [12902380] Mol Cell. 2003 Aug;12(2):525-32 [14536091] Mol Cancer Res. 2004 Jan;2(1):53-61 [14757846] Mol Cell Biol. 2009 Jan;29(1):68-82 [18955500] Circ Res. 2009 Mar 13;104(5):589-99 [19168442] Cell. 2009 May 15;137(4):600-2 [19450507] Cell. 2009 May 15;137(4):708-20 [19450518] Nat Rev Mol Cell Biol. 2009 Nov;10(11):741-54 [19773805] Nucleic Acids Res. 2010 Jan;38(1):159-71 [19854946] Nature. 2010 Jan 28;463(7280):457-63 [20110989] Chem Biol. 2010 May 28;17(5):421-33 [20534341] EMBO J. 2010 Jul 7;29(13):2126-34 [20526281] Trends Biochem Sci. 2010 Sep;35(9):497-504 [20418102] Biochim Biophys Acta. 2010 Dec;1806(2):240-50 [20600630] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-10-2491 ER - TY - JOUR T1 - Brain mu-opioid receptor binding predicts treatment outcome in cocaine-abusing outpatients. AN - 756660543; 20579973 AB - Cocaine users not seeking treatment have increased regional brain mu-opioid receptor (mOR) binding that correlates with cocaine craving and tendency to relapse. In cocaine-abusing outpatients in treatment, the relationship of mOR binding and treatment outcome is unknown. We determined whether regional brain mOR binding before treatment correlates with outcome and compared it with standard clinical predictors of outcome. Twenty-five individuals seeking outpatient treatment for cocaine abuse or dependence (DSM-IV) received up to 12 weeks of cognitive-behavioral therapy and cocaine abstinence reinforcement, whereby each cocaine-free urine was reinforced with vouchers redeemable for goods. Regional brain mOR binding was measured before treatment using positron emission tomography with [¹¹C]]-carfentanil (a selective mOR agonist). Main outcome measures were: 1) overall percentage of urines positive for cocaine during first month of treatment; and 2) longest duration (weeks) of abstinence from cocaine during treatment, all verified by urine toxicology. Elevated mOR binding in the medial frontal and middle frontal gyri before treatment correlated with greater cocaine use during treatment. Elevated mOR binding in the anterior cingulate, medial frontal, middle frontal, middle temporal, and sublobar insular gyri correlated with shorter duration of cocaine abstinence during treatment. Regional mOR binding contributed significant predictive power for treatment outcome beyond that of standard clinical variables such as baseline drug and alcohol use. Elevated mOR binding in brain regions associated with reward sensitivity is a significant independent predictor of treatment outcome in cocaine-abusing outpatients, suggesting a key role for the brain endogenous opioid system in cocaine addiction. Published by Elsevier Inc. JF - Biological psychiatry AU - Ghitza, Udi E AU - Preston, Kenzie L AU - Epstein, David H AU - Kuwabara, Hiroto AU - Endres, Christopher J AU - Bencherif, Badreddine AU - Boyd, Susan J AU - Copersino, Marc L AU - Frost, J James AU - Gorelick, David A AD - Intramural Research Program, Clinical Pharmacology and Therapeutics Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA. ghitzau@nida.nih.gov Y1 - 2010/10/15/ PY - 2010 DA - 2010 Oct 15 SP - 697 EP - 703 VL - 68 IS - 8 KW - Receptors, Opioid, mu KW - 0 KW - Cocaine KW - I5Y540LHVR KW - carfentanil KW - LA9DTA2L8F KW - Fentanyl KW - UF599785JZ KW - Index Medicus KW - Magnetic Resonance Imaging KW - Positron-Emission Tomography -- methods KW - Cocaine -- urine KW - Humans KW - Adult KW - Treatment Outcome KW - Fentanyl -- metabolism KW - Predictive Value of Tests KW - Radioligand Assay -- methods KW - Fentanyl -- analogs & derivatives KW - Male KW - Female KW - Cocaine-Related Disorders -- therapy KW - Brain -- metabolism KW - Receptors, Opioid, mu -- metabolism KW - Cocaine-Related Disorders -- metabolism KW - Brain -- diagnostic imaging KW - Cognitive Therapy -- methods KW - Cocaine-Related Disorders -- urine KW - Cocaine-Related Disorders -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756660543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Brain+mu-opioid+receptor+binding+predicts+treatment+outcome+in+cocaine-abusing+outpatients.&rft.au=Ghitza%2C+Udi+E%3BPreston%2C+Kenzie+L%3BEpstein%2C+David+H%3BKuwabara%2C+Hiroto%3BEndres%2C+Christopher+J%3BBencherif%2C+Badreddine%3BBoyd%2C+Susan+J%3BCopersino%2C+Marc+L%3BFrost%2C+J+James%3BGorelick%2C+David+A&rft.aulast=Ghitza&rft.aufirst=Udi&rft.date=2010-10-15&rft.volume=68&rft.issue=8&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=1873-2402&rft_id=info:doi/10.1016%2Fj.biopsych.2010.05.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-09 N1 - Date created - 2010-10-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuropsychopharmacology. 2009 Jul;34(8):1946-57 [19279569] Trends Neurosci. 2009 Jan;32(1):56-67 [18986715] Psychopharmacology (Berl). 2008 Nov;200(4):475-86 [18762918] Neurosci Biobehav Rev. 2010 Nov;35(2):220-31 [20170672] Am J Psychiatry. 2000 Jan;157(1):127-9 [10618027] Am J Psychiatry. 2000 Nov;157(11):1789-98 [11058476] Ann N Y Acad Sci. 2001 Jun;937:74-92 [11458541] J Neurosci. 2002 Jun 15;22(12):5100-7 [12077205] Drug Alcohol Depend. 2002 Sep 1;68(1):35-48 [12167551] Am J Psychiatry. 2002 Oct;159(10):1642-52 [12359667] Nucl Med Biol. 2003 Feb;30(2):177-86 [12623117] Psychol Addict Behav. 2003 Mar;17(1):73-82 [12665084] Clin Pharmacol Ther. 2004 Jan;75(1):34-48 [14749690] Biol Psychiatry. 2004 Apr 1;55(7):759-65 [15039006] J Consult Clin Psychol. 1984 Oct;52(5):774-83 [6501663] J Comput Assist Tomogr. 1985 Mar-Apr;9(2):231-6 [2982931] J Nerv Ment Dis. 1985 Jul;173(7):412-23 [4009158] J Pers Soc Psychol. 1986 Mar;50(3):571-9 [3701593] J Consult Clin Psychol. 1988 Oct;56(5):715-20 [3192787] J Comput Assist Tomogr. 1995 Sep-Oct;19(5):788-96 [7560327] Brain Res. 1995 Jun 5;682(1-2):245-50 [7552322] J Cereb Blood Flow Metab. 1996 Sep;16(5):834-40 [8784228] Nat Med. 1996 Nov;2(11):1225-9 [8898749] IEEE Trans Med Imaging. 1997 Apr;16(2):187-98 [9101328] Am J Psychiatry. 1999 Jun;156(6):842-8 [10360121] Eur Neuropsychopharmacol. 2005 May;15(3):297-303 [15820419] J Neurosci. 2005 May 4;25(18):4512-20 [15872098] Biol Psychiatry. 2005 Jun 15;57(12):1573-82 [15953495] Arch Gen Psychiatry. 2005 Jul;62(7):761-8 [15997017] Eur J Pharmacol. 2005 Dec 5;526(1-3):36-50 [16289451] Neuropsychopharmacology. 2006 Dec;31(12):2716-27 [16971900] Am J Addict. 2006 Nov-Dec;15(6):434-9 [17182445] Science. 2007 Jan 26;315(5811):531-4 [17255515] Am J Drug Alcohol Abuse. 2007;33(2):191-206 [17497542] Biol Psychiatry. 2007 Jun 1;61(11):1252-9 [16945342] Cochrane Database Syst Rev. 2007;(3):CD003023 [17636713] Am J Psychiatry. 2008 Nov;165(11):1442-8 [18765480] Comment In: Biol Psychiatry. 2010 Oct 15;68(8):685-6 [20888455] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.biopsych.2010.05.003 ER - TY - JOUR T1 - Comparison of multivariate classifiers and response normalizations for pattern-information fMRI AN - 754896468; 13525182 AB - A popular method for investigating whether stimulus information is present in fMRI response patterns is to attempt to "decode" the stimuli from the response patterns with a multivariate classifier. The sensitivity for detecting the information depends on the particular classifier used. However, little is known about the relative performance of different classifiers on fMRI data. Here we compared six multivariate classifiers and investigated how the response-amplitude estimate used (beta- or t-value) and different pattern normalizations affect classification performance. The compared classifiers were a pattern-correlation classifier, a k-nearest-neighbors classifier, Fisher's linear discriminant, Gaussian naive Bayes, and linear and nonlinear (radial-basis-function kernel) support vector machines. We compared these classifiers' accuracy at decoding the category of visual objects from response patterns in human early visual and inferior temporal cortex acquired in an event-related design with BOLD fMRI at 3 T using SENSE and isotropic voxels of about 2-mm width. Overall, Fisher's linear discriminant (with an optimal-shrinkage covariance estimator) and the linear support vector machine performed best. The pattern-correlation classifier often performed similarly as those two classifiers. The nonlinear classifiers never performed better and sometimes significantly worse than the linear classifiers, suggesting overfitting. Defining response patterns by t-values (or in error-standard-deviation units) rather than by beta estimates (in % signal change) to define the patterns appeared advantageous. Cross-validation by a leave-one-stimulus-pair-out method gave higher accuracies than a leave-one-run-out method, suggesting that generalization to independent runs (which more safely ensures independence of the test set) is more challenging than generalization to novel stimuli within the same category. Independent selection of fewer more visually responsive voxels tended to yield better decoding performance for all classifiers. Normalizing mean and standard deviation of the response patterns either across stimuli or across voxels had no significant effect on decoding performance. Overall our results suggest that linear decoders based on t-value patterns may perform best in the present scenario of visual object representations measured for about 60 min per subject with 3T fMRI. JF - NeuroImage AU - Misaki, Masaya AU - Kim, Youn AU - Bandettini, Peter A AU - Kriegeskorte, Nikolaus AD - Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA, misakim@mail.nih.govnikolaus.kriegeskorte@mrc-cbu.cam.ac.uk Y1 - 2010/10/15/ PY - 2010 DA - 2010 Oct 15 SP - 103 EP - 118 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 53 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Multi-voxel pattern analysis KW - decoding KW - classification analysis KW - fMRI KW - normalization KW - pattern-information analysis KW - Neuroimaging KW - Standard deviation KW - Data processing KW - Classification KW - Cortex (visual) KW - Bayesian analysis KW - Functional magnetic resonance imaging KW - Kernels KW - Cortex (temporal) KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754896468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Comparison+of+multivariate+classifiers+and+response+normalizations+for+pattern-information+fMRI&rft.au=Misaki%2C+Masaya%3BKim%2C+Youn%3BBandettini%2C+Peter+A%3BKriegeskorte%2C+Nikolaus&rft.aulast=Misaki&rft.aufirst=Masaya&rft.date=2010-10-15&rft.volume=53&rft.issue=1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.05.051 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Data processing; Standard deviation; Classification; Bayesian analysis; Cortex (visual); Functional magnetic resonance imaging; Kernels; Cortex (temporal) DO - http://dx.doi.org/10.1016/j.neuroimage.2010.05.051 ER - TY - JOUR T1 - A transgenic mouse model demonstrates a dominant negative effect of a point mutation in the RPS19 gene associated with Diamond-Blackfan anemia AN - 954586512; 13842881 AB - Diamond Blackfan anemia (DBA) is an inherited erythroblastopenia associated with mutations in at least 8 different ribosomal protein genes. Mutations in the gene encoding ribosomal protein S19 (RPS19) have been identified in approximately 25% of DBA families. Most of these mutations disrupt either the translation or stability of the RPS19 protein and are predicted to cause DBA by haploinsufficiency. However, approximately 30% of RPS19 mutations are missense mutations that do not alter the stability of the RPS19 protein and are hypothesized to act by a dominant negative mechanism. To formally test this hypothesis, we generated a transgenic mouse model expressing an RPS19 mutation in which an arginine residue is replaced with a tryptophan residue at codon 62 (RPS19R62W). Constitutive expression of RPS19R62W in developing mice was lethal. Conditional expression of RPS19R62W resulted in growth retardation, a mild anemia with reduced numbers of erythroid progenitors, and significant inhibition of terminal erythroid maturation, similar to DBA. RNA profiling demonstrated more than 700 dysregulated genes belonging to the same pathways that are disrupted in RNA profiles of DBA patient cells. We conclude that RPS19R62W is a dominant negative DBA mutation. JF - Blood AU - Devlin, Emily E AU - DaCosta, Lydie AU - Mohandas, Narla AU - Elliott, Gene AU - Bodine, David M AD - Hematopoiesis Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute (NHGRI), Bethesda, MD Y1 - 2010/10/14/ PY - 2010 DA - 2010 Oct 14 SP - 2826 EP - 2835 PB - The American Society of Hematology VL - 116 IS - 15 SN - 1528-0020, 1528-0020 KW - Genetics Abstracts; Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - Growth rate KW - Translation KW - Tryptophan KW - Missense mutation KW - rps19 gene KW - Arginine KW - Point mutation KW - Animal models KW - Anemia KW - Transgenic mice KW - Blood KW - Stem cells KW - RNA KW - Ribosomal proteins KW - haploinsufficiency KW - Codons KW - W 30925:Genetic Engineering KW - X 24310:Pharmaceuticals KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954586512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=A+transgenic+mouse+model+demonstrates+a+dominant+negative+effect+of+a+point+mutation+in+the+RPS19+gene+associated+with+Diamond-Blackfan+anemia&rft.au=Devlin%2C+Emily+E%3BDaCosta%2C+Lydie%3BMohandas%2C+Narla%3BElliott%2C+Gene%3BBodine%2C+David+M&rft.aulast=Devlin&rft.aufirst=Emily&rft.date=2010-10-14&rft.volume=116&rft.issue=15&rft.spage=2826&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=15280020&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Growth rate; Tryptophan; Translation; Missense mutation; Arginine; rps19 gene; Point mutation; Anemia; Animal models; Transgenic mice; Blood; Stem cells; RNA; Ribosomal proteins; haploinsufficiency; Codons ER - TY - JOUR T1 - Rescue of Impaired Fear Extinction and Normalization of Cortico-Amygdala Circuit Dysfunction in a Genetic Mouse Model by Dietary Zinc Restriction AN - 807280382; 13843716 AB - Fear extinction is impaired in neuropsychiatric disorders, including posttraumatic stress disorder. Identifying drugs that facilitate fear extinction in animal models provides leads for novel pharmacological treatments for these disorders. Zinc (Zn) is expressed in neurons in a cortico-amygdala circuit mediating fear extinction, and modulates neurotransmitter systems regulating extinction. We previously found that the 129S1/SvImJ mouse strain (S1) exhibited a profound impairment in fear extinction, coupled with abnormalities in the activation of the extinction circuit. Here, we tested the role of Zn in fear extinction in S1 and C57BL/6N reference strain (B6) by feeding the mice a Zn-restricted diet (ZnR) and testing for fear extinction, as well as neuronal activation of the extinction circuit via quantification of the immediate-early genes c-Fos and Zif268. Results showed that (preconditioning or postconditioning) ZnR completely rescued deficient extinction learning and long-term extinction retrieval in S1 and expedited extinction learning in B6, without affecting fear acquisition or fear expression. The extinction-facilitating effects of ZnR were associated with the normalization of Zif268 and/or c-Fos expression in cortico-amygdala regions of S1. Specifically, ZnR increased activity in infralimbic cortex, lateral and basolateral amygdala nuclei, and lateral central amygdala nucleus, and decreased activity in prelimbic and insular cortices and medial central amygdala nucleus. ZnR also increased activation in the main intercalated nucleus and decreased activation of the medial paracapsular intercalated mass in S1. Our findings reveal a novel role for Zn in fear extinction and further support the utility of the S1 model for identifying extinction facilitating drugs. JF - Journal of Neuroscience AU - Whittle, Nigel AU - Hauschild, Markus AU - Lubec, Gert AU - Holmes, Andrew AU - Singewald, Nicolas AD - Department of Pharmacology and Toxicology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, A-6020 Innsbruck, Austria, Department of Pediatrics, Medical University of Vienna, A-1090 Vienna, Austria, and Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, Maryland 20852 Y1 - 2010/10/13/ PY - 2010 DA - 2010 Oct 13 SP - 13586 EP - 13596 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Washington DC 20036 USA VL - 30 IS - 41 SN - 0270-6474, 0270-6474 KW - Genetics Abstracts; Toxicology Abstracts; CSA Neurosciences Abstracts KW - Diets KW - Feeding KW - Learning KW - Cortex (insular) KW - Extinction KW - Animal models KW - Circuits KW - c-Fos protein KW - Fear conditioning KW - Post-traumatic stress disorder KW - Mental disorders KW - Nervous system KW - Cortex KW - Neurons KW - Zinc KW - Amygdala KW - Neurotransmitters KW - Immediate-early proteins KW - EGR-1 protein KW - Drugs KW - N3 11001:Behavioral and Cognitive Neuroscience KW - X 24360:Metals KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807280382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Rescue+of+Impaired+Fear+Extinction+and+Normalization+of+Cortico-Amygdala+Circuit+Dysfunction+in+a+Genetic+Mouse+Model+by+Dietary+Zinc+Restriction&rft.au=Whittle%2C+Nigel%3BHauschild%2C+Markus%3BLubec%2C+Gert%3BHolmes%2C+Andrew%3BSingewald%2C+Nicolas&rft.aulast=Whittle&rft.aufirst=Nigel&rft.date=2010-10-13&rft.volume=30&rft.issue=41&rft.spage=13586&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Diets; Feeding; Learning; Cortex (insular); Extinction; Animal models; Circuits; Fear conditioning; c-Fos protein; Post-traumatic stress disorder; Nervous system; Mental disorders; Cortex; Neurons; Zinc; Amygdala; Immediate-early proteins; Neurotransmitters; Drugs; EGR-1 protein ER - TY - JOUR T1 - Human Anti-Plague Monoclonal Antibodies Protect Mice from Yersinia pestis in a Bubonic Plague Model AN - 1776644476; 14025740 AB - Yersinia pestis is the etiologic agent of plague that has killed more than 200 million people throughout the recorded history of mankind. Antibiotics may provide little immediate relief to patients who have a high bacteremia or to patients infected with an antibiotic resistant strain of plague. Two virulent factors of Y. pestis are the capsid F1 protein and the low-calcium response (Lcr) V-protein or V-antigen that have been proven to be the targets for both active and passive immunization. There are mouse monoclonal antibodies (mAbs) against the F1- and V-antigens that can passively protect mice in a murine model of plague; however, there are no anti-Yersinia pestis monoclonal antibodies available for prophylactic or therapeutic treatment in humans. We identified one anti-F1-specific human mAb (m252) and two anti-V-specific human mAb (m253, m254) by panning a naieve phage-displayed Fab library against the F1- and V-antigens. The Fabs were converted to IgG1s and their binding and protective activities were evaluated. M252 bound weakly to peptides located at the F1 N-terminus where a protective mouse anti-F1 mAb also binds. M253 bound strongly to a V-antigen peptide indicating a linear epitope; m254 did not bind to any peptide from a panel of 53 peptides suggesting that its epitope may be conformational. M252 showed better protection than m253 and m254 against a Y, pestis challenge in a plague mouse model. A synergistic effect was observed when the three antibodies were combined. Incomplete to complete protection was achieved when m252 was given at different times post-challenge. These antibodies can be further studied to determine their potential as therapeutics or prophylactics in Y. pestis infection in humans. JF - PLoS ONE AU - Xiao, Xiaodong AU - Zhu, Zhongyu AU - Dankmeyer, Jennifer L AU - Wormald, Michael M AU - Fast, Randy L AU - Worsham, Patricia L AU - Cote, Christopher K AU - Amemiya, Kei AU - Dimitrov, Dimiter S AD - Protein Interactions Group, Center for Cancer Research Nanobiology Program, National Cancer Institute-Frederick, National Institutes of Health, Frederick, Maryland, United States of America Y1 - 2010/10/13/ PY - 2010 DA - 2010 Oct 13 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - 0 KW - Microbiology Abstracts B: Bacteriology KW - Capsids KW - Monoclonal antibodies KW - Panning KW - Animal models KW - Yersinia pestis KW - Bacteremia KW - Antibiotics KW - Infection KW - N-Terminus KW - Immunoglobulin G KW - Immunization (passive) KW - Plague KW - Fab KW - Epitopes KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776644476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Human+Anti-Plague+Monoclonal+Antibodies+Protect+Mice+from+Yersinia+pestis+in+a+Bubonic+Plague+Model&rft.au=Xiao%2C+Xiaodong%3BZhu%2C+Zhongyu%3BDankmeyer%2C+Jennifer+L%3BWormald%2C+Michael+M%3BFast%2C+Randy+L%3BWorsham%2C+Patricia+L%3BCote%2C+Christopher+K%3BAmemiya%2C+Kei%3BDimitrov%2C+Dimiter+S&rft.aulast=Xiao&rft.aufirst=Xiaodong&rft.date=2010-10-13&rft.volume=5&rft.issue=0&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0013047 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Capsids; Monoclonal antibodies; Animal models; Panning; Bacteremia; Antibiotics; Infection; N-Terminus; Immunoglobulin G; Immunization (passive); Plague; Fab; Epitopes; Yersinia pestis DO - http://dx.doi.org/10.1371/journal.pone.0013047 ER - TY - JOUR T1 - Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation AN - 968161407; 14152551 AB - Erythrophagocytosis and inflammation from activated macrophages occur in distinct clinical scenarios. The presence of CD8+ T cells and interferon- gamma (IFN- gamma ) production is required to induce disease in mouse models of hemophagocytic lymphohistiocytosis. We investigated the roles of a different class of proinflammatory cytokines, interleukin-4 (IL-4) and IL-13, in the induction of inflammatory tissue macrophage accumulation and/or hemophagocytosis. We found that large amounts of IL-4, but not IL-13, delivered via an implanted mini-pump or IL-4/anti-IL-4 complexes, lead to substantial YM1+ tissue macrophage accumulation, erythrophagocytosis within the liver, spleen, and bone marrow, decreased hemoglobin and platelet levels, and acute weight loss. This effect is not dependent on the presence of antibody or T cells, as treatment of Rag2-/- mice leads to similar disease, and IFN- gamma neutralization during IL-4 treatment had no effect. IL-4 treatment results in suppression of IL-12, elevation of serum IFN- gamma , IL-10, and the murine IL-8 homolog KC, but not IL-6, IL-1 beta , or tumor necrosis factor- alpha . Finally, mice transgenic for IL-4 production developed tissue macrophage accumulation, disruption of splenic architecture, bone marrow hypocellularity, and extramedullary hematopoiesis. These data describe a novel pathophysiologic pathway for erythrophagocytosis in the context of tissue macrophage accumulation and inflammation involving elevations in IL-4 and alternative macrophage activation. JF - Blood AU - Milner, Joshua D AU - Orekov, Tatyana AU - Ward, Jerrold M AU - Cheng, Lily AU - Torres-Velez, Fernando AU - Junttila, Ilkka AU - Sun, Guangping AU - Buller, Mark AU - Morris, Suzanne C AU - Finkelman, Fred D AU - Paul, William E AD - Laboratory of Immunology and Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD Y1 - 2010/10/07/ PY - 2010 DA - 2010 Oct 07 SP - 2476 EP - 2483 PB - The American Society of Hematology VL - 116 IS - 14 SN - 1528-0020, 1528-0020 KW - Immunology Abstracts; Toxicology Abstracts KW - Animal models KW - Interleukin 4 KW - F 06935:Development, Aging & Organ Systems KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968161407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Sustained+IL-4+exposure+leads+to+a+novel+pathway+for+hemophagocytosis%2C+inflammation%2C+and+tissue+macrophage+accumulation&rft.au=Milner%2C+Joshua+D%3BOrekov%2C+Tatyana%3BWard%2C+Jerrold+M%3BCheng%2C+Lily%3BTorres-Velez%2C+Fernando%3BJunttila%2C+Ilkka%3BSun%2C+Guangping%3BBuller%2C+Mark%3BMorris%2C+Suzanne+C%3BFinkelman%2C+Fred+D%3BPaul%2C+William+E&rft.aulast=Milner&rft.aufirst=Joshua&rft.date=2010-10-07&rft.volume=116&rft.issue=14&rft.spage=2476&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=15280020&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2014-03-20 N1 - SubjectsTermNotLitGenreText - Interleukin 4 ER - TY - JOUR T1 - Staphylococcus epidermidis Strategies to Avoid Killing by Human Neutrophils AN - 839682776; 13970011 AB - Staphylococcus epidermidis is a leading nosocomial pathogen. In contrast to its more aggressive relative S. aureus, it causes chronic rather than acute infections. In highly virulent S. aureus, phenol-soluble modulins (PSMs) contribute significantly to immune evasion and aggressive virulence by their strong ability to lyse human neutrophils. Members of the PSM family are also produced by S. epidermidis, but their role in immune evasion is not known. Notably, strong cytolytic capacity of S. epidermidis PSMs would be at odds with the notion that S. epidermidis is a less aggressive pathogen than S. aureus, prompting us to examine the biological activities of S. epidermidis PSMs. Surprisingly, we found that S. epidermidis has the capacity to produce PSMd, a potent leukocyte toxin, representing the first potent cytolysin to be identified in that pathogen. However, production of strongly cytolytic PSMs was low in S. epidermidis, explaining its low cytolytic potency. Interestingly, the different approaches of S. epidermidis and S. aureus to causing human disease are thus reflected by the adaptation of biological activities within one family of virulence determinants, the PSMs. Nevertheless, S. epidermidis has the capacity to evade neutrophil killing, a phenomenon we found is partly mediated by resistance mechanisms to antimicrobial peptides (AMPs), including the protease SepA, which degrades AMPs, and the AMP sensor/resistance regulator, Aps (GraRS). These findings establish a significant function of SepA and Aps in S. epidermidis immune evasion and explain in part why S. epidermidis may evade elimination by innate host defense despite the lack of cytolytic toxin expression. Our study shows that the strategy of S. epidermidis to evade elimination by human neutrophils is characterized by a passive defense approach and provides molecular evidence to support the notion that S. epidermidis is a less aggressive pathogen than S. aureus. Staphylococcus epidermidis frequently causes chronic infections, indicating pronounced capacity to evade host defenses. However, S. epidermidis is in general much less aggressive than its close relative, S. aureus. Here we identify molecular underpinnings of that discrepancy by showing that S. epidermidis immune evasion mechanisms are limited to those involving molecules that protect against or eliminate antimicrobial agents secreted by white blood cells, while immune evasion mechanisms of virulent S. aureus include the production of destructive toxins. This is especially noteworthy, because we demonstrate here for the first time that S. epidermidis has the capacity to produce a toxin with great potential to destroy white blood cells, but keeps its production at a very limited level. Thus, our study shows that two closely related human pathogens have adapted specific molecular mechanisms to evade host defenses, reflecting the unique approach used by each to cause human disease. JF - PLoS Pathogens AU - Cheung, Gordon YC AU - Rigby, Kevin AU - Wang, Rong AU - Queck, Shu Y AU - Braughton, Kevin R AU - Whitney, Adeline R AU - Teintze, Martin AU - DeLeo, Frank R AU - Otto, Michael AD - Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2010/10/07/ PY - 2010 DA - 2010 Oct 07 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 USA VL - 6 IS - 0 SN - 1553-7366, 1553-7366 KW - Microbiology Abstracts B: Bacteriology KW - Molecular modelling KW - Adaptations KW - Leukocytes (neutrophilic) KW - Pathogens KW - Toxins KW - Antimicrobial agents KW - Virulence KW - cytolysins KW - Chronic infection KW - Proteinase KW - Staphylococcus epidermidis KW - Antimicrobial peptides KW - Hospitals KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839682776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Pathogens&rft.atitle=Staphylococcus+epidermidis+Strategies+to+Avoid+Killing+by+Human+Neutrophils&rft.au=Cheung%2C+Gordon+YC%3BRigby%2C+Kevin%3BWang%2C+Rong%3BQueck%2C+Shu+Y%3BBraughton%2C+Kevin+R%3BWhitney%2C+Adeline+R%3BTeintze%2C+Martin%3BDeLeo%2C+Frank+R%3BOtto%2C+Michael&rft.aulast=Cheung&rft.aufirst=Gordon&rft.date=2010-10-07&rft.volume=6&rft.issue=0&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Pathogens&rft.issn=15537366&rft_id=info:doi/10.1371%2Fjournal.ppat.1001133 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Virulence; Molecular modelling; Adaptations; cytolysins; Chronic infection; Leukocytes (neutrophilic); Proteinase; Pathogens; Antimicrobial peptides; Toxins; Antimicrobial agents; Hospitals; Staphylococcus epidermidis DO - http://dx.doi.org/10.1371/journal.ppat.1001133 ER - TY - JOUR T1 - Dengue Virus Ensures Its Fusion in Late Endosomes Using Compartment-Specific Lipids AN - 815539269; 13970009 AB - Many enveloped viruses invade cells via endocytosis and use different environmental factors as triggers for virus-endosome fusion that delivers viral genome into cytosol. Intriguingly, dengue virus (DEN), the most prevalent mosquito-borne virus that infects up to 100 million people each year, fuses only in late endosomes, while activation of DEN protein fusogen glycoprotein E is triggered already at pH characteristic for early endosomes. Are there any cofactors that time DEN fusion to virion entry into late endosomes? Here we show that DEN utilizes bis(monoacylglycero)phosphate, a lipid specific to late endosomes, as a co-factor for its endosomal acidification-dependent fusion machinery. Effective virus fusion to plasma- and intracellular- membranes, as well as to protein-free liposomes, requires the target membrane to contain anionic lipids such as bis(monoacylglycero)phosphate and phosphatidylserine. Anionic lipids act downstream of low-pH-dependent fusion stages and promote the advance from the earliest hemifusion intermediates to the fusion pore opening. To reach anionic lipid-enriched late endosomes, DEN travels through acidified early endosomes, but we found that low pH-dependent loss of fusogenic properties of DEN is relatively slow in the presence of anionic lipid-free target membranes. We propose that anionic lipid-dependence of DEN fusion machinery protects it against premature irreversible restructuring and inactivation and ensures viral fusion in late endosomes, where the virus encounters anionic lipids for the first time during entry. Currently there are neither vaccines nor effective therapies for DEN, and the essential role of the newly identified DEN-bis(monoacylglycero)phosphate interactions in viral genome escape from the endosome suggests a novel target for drug design. Dengue virus infection is a growing public health problem with up to 100 million cases annually, and neither vaccines nor effective therapies are available. To search for the ways of preventing and treating dengue infections we need to better understand their molecular mechanisms. As with many other viruses, dengue virus enters cells by fusion between the viral membrane and the membrane of intracellular vesicles (endosomes). In this work we explored the fusion stage of dengue virus entry in different experimental systems ranging from virus fusion to artificial lipid membranes to fusion inside the cells. While earlier work on dengue virus entry has focused on viral protein that mediates fusion, we found that effective action of this protein requires specific lipid composition of the membrane the virus fuses to. In effect, this lipid dependence allows virus to control intracellular location of the fusion event and, thus, the place of its RNA release by exploiting cell-controlled differences between lipid compositions of different organelles the virus travels through. The essential role of the interactions between dengue virus and its lipid cofactors during viral entry suggests that these interactions may be targeted in drug design. JF - PLoS Pathogens AU - Zaitseva, Elena AU - Yang, Sung-Tae AU - Melikov, Kamran AU - Pourmal, Sergei AU - Chernomordik, Leonid V AD - Section on Membrane Biology, Laboratory of Cellular and Molecular Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2010/10/07/ PY - 2010 DA - 2010 Oct 07 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 USA VL - 6 IS - 0 SN - 1553-7366, 1553-7366 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Virology & AIDS Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Dengue virus KW - glycoprotein E KW - Virions KW - Genomes KW - Molecular modelling KW - Human diseases KW - Anions KW - Lipids KW - Viruses KW - Disease control KW - Infection KW - Environmental factors KW - Public health KW - phosphatidylserine KW - Dengue KW - Lipid composition KW - Membrane vesicles KW - pH effects KW - Membrane fusion KW - Drug development KW - Pathogens KW - Liposomes KW - Endocytosis KW - endosomes KW - Cofactors KW - RNA KW - Viral diseases KW - Lipid membranes KW - Cytosol KW - Fusion protein KW - Vaccines KW - Organelles KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815539269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Pathogens&rft.atitle=Dengue+Virus+Ensures+Its+Fusion+in+Late+Endosomes+Using+Compartment-Specific+Lipids&rft.au=Zaitseva%2C+Elena%3BYang%2C+Sung-Tae%3BMelikov%2C+Kamran%3BPourmal%2C+Sergei%3BChernomordik%2C+Leonid+V&rft.aulast=Zaitseva&rft.aufirst=Elena&rft.date=2010-10-07&rft.volume=6&rft.issue=0&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Pathogens&rft.issn=15537366&rft_id=info:doi/10.1371%2Fjournal.ppat.1001131 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Genomes; Human diseases; Anions; Viral diseases; Lipids; Viruses; Disease control; Vaccines; Public health; Virions; glycoprotein E; Molecular modelling; Infection; Environmental factors; phosphatidylserine; Dengue; Lipid composition; Membrane vesicles; pH effects; Membrane fusion; Drug development; Pathogens; Liposomes; Endocytosis; endosomes; Cofactors; RNA; Lipid membranes; Cytosol; Fusion protein; Organelles; Dengue virus DO - http://dx.doi.org/10.1371/journal.ppat.1001131 ER - TY - JOUR T1 - Age at cancer diagnosis among persons with AIDS in the United States. AN - 756667037; 20921544 AB - Studies have reported young ages at cancer diagnosis in HIV-infected persons and have suggested that HIV accelerates carcinogenesis. However, these comparisons did not account for differences in population age structures. To compare ages at diagnosis for non-AIDS-defining types of cancer that occur in both the AIDS and general populations, after adjustment for differences in age and other demographic characteristics between these populations. Registry linkage study. 15 HIV/AIDS and cancer registry databases in the United States. 212 055 persons with AIDS enrolled in the U.S. HIV/AIDS Cancer Match Study from 1996 to 2007. Comparison of age-at-diagnosis distributions for various types of cancer in both the AIDS and general populations, after adjustment for age and other demographic characteristics. The proportion of person-time contributed by older persons (age ≥65 years) was far smaller in the AIDS population (1.5%) than in the general population (12.5%). Reflecting this difference, the ages at diagnosis for most types of cancer were approximately 20 years younger among persons with AIDS. However, after adjustment for differences in the populations at risk, the median ages at diagnosis in the AIDS and general populations did not differ for most types of cancer (for example, colon, prostate, or breast cancer; all P > 0.100). In contrast, ages at diagnosis of lung (median, 50 vs. 54 years) and anal cancer (median, 42 vs. 45 years) were significantly younger in persons with AIDS than expected in the general population (P < 0.001), and the age at diagnosis of Hodgkin lymphoma was significantly older (median, 42 vs. 40 years; P < 0.001). Information on other cancer risk factors, including cigarette smoking, was not available. Analysis was restricted to non-Hispanic white and black persons who had AIDS, which could limit the generalizability of the findings to other racial and ethnic groups or to persons with HIV but not AIDS. For most types of cancer, the age at diagnosis is similar in the AIDS and general populations, after adjustment for the ages of the populations at risk. Modest age differences remained for a few types of cancer, which may indicate either acceleration of carcinogenesis by HIV or earlier exposure to cancer risk factors. National Cancer Institute. JF - Annals of internal medicine AU - Shiels, Meredith S AU - Pfeiffer, Ruth M AU - Engels, Eric A AD - National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA. shielsms@mail.nih.gov Y1 - 2010/10/05/ PY - 2010 DA - 2010 Oct 05 SP - 452 EP - 460 VL - 153 IS - 7 KW - Abridged Index Medicus KW - Index Medicus KW - Lung Neoplasms -- complications KW - Hodgkin Disease -- diagnosis KW - Age of Onset KW - Humans KW - Aged KW - Anus Neoplasms -- complications KW - Hodgkin Disease -- complications KW - Hodgkin Disease -- epidemiology KW - Registries KW - Lung Neoplasms -- diagnosis KW - Lung Neoplasms -- epidemiology KW - Anus Neoplasms -- diagnosis KW - Risk Factors KW - Adult KW - Incidence KW - Middle Aged KW - Anus Neoplasms -- epidemiology KW - United States -- epidemiology KW - Male KW - Female KW - Acquired Immunodeficiency Syndrome -- complications KW - Neoplasms -- diagnosis KW - Neoplasms -- complications KW - Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756667037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Age+at+cancer+diagnosis+among+persons+with+AIDS+in+the+United+States.&rft.au=Shiels%2C+Meredith+S%3BPfeiffer%2C+Ruth+M%3BEngels%2C+Eric+A&rft.aulast=Shiels&rft.aufirst=Meredith&rft.date=2010-10-05&rft.volume=153&rft.issue=7&rft.spage=452&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/10.7326%2F0003-4819-153-7-201010050-00008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-16 N1 - Date created - 2010-10-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lancet. 1996 Jun 1;347(9014):1551; author reply 1551-2 [8684118] Lancet. 1996 Mar 23;347(9004):798-800 [8622336] N Engl J Med. 1998 Mar 26;338(13):853-60 [9516219] Gut. 1998 Feb;42(2):170-4 [9536939] JAMA. 1998 Nov 4;280(17):1497-503 [9809730] AIDS. 2004 Nov 19;18(17):2285-93 [15577541] J Natl Cancer Inst. 2005 Mar 16;97(6):425-32 [15770006] AIDS. 2006 Jul 13;20(11):1531-8 [16847408] AIDS. 2006 Aug 1;20(12):1645-54 [16868446] J Acquir Immune Defic Syndr. 2006 Sep;43(1):47-55 [16936558] Br J Cancer. 2006 Sep 4;95(5):642-8 [16868538] Blood. 2006 Dec 1;108(12):3786-91 [16917006] AIDS Patient Care STDS. 2007;21 Suppl 1:S3-8 [17563287] Lancet. 2007 Jul 7;370(9581):59-67 [17617273] J Hepatol. 2007 Oct;47(4):527-37 [17692986] AIDS. 2008 Feb 19;22(4):489-96 [18301061] Int J Cancer. 2008 Jul 1;123(1):187-94 [18435450] Ann Intern Med. 2008 May 20;148(10):728-36 [18490686] Curr HIV/AIDS Rep. 2008 Aug;5(3):150-8 [18627664] Clin Infect Dis. 2008 Aug 15;47(4):542-53 [18627268] J Gen Intern Med. 2008 Sep;23(9):1452-7 [18618198] Curr Opin HIV AIDS. 2009 Jan;4(1):3-10 [19339934] Blood. 2009 Jun 4;113(23):5737-42 [19336755] Clin Lymphoma Myeloma. 2009 Jun;9(3):206-16 [19525189] MMWR Recomm Rep. 2009 Sep 4;58(RR-11):1-166 [19730409] Clin Colorectal Cancer. 2009 Oct;8(4):215-9 [19822512] AIDS. 2009 Nov 13;23(17):2337-45 [19741479] J Acquir Immune Defic Syndr. 2009 Dec;52(5):611-22 [19770804] AIDS. 2010 Feb 20;24(4):535-43 [19926961] Br J Surg. 1997 Aug;84(8):1068-71 [9278642] MMWR Recomm Rep. 1992 Dec 18;41(RR-17):1-19 [1361652] Arch Pathol Lab Med. 2003 May;127(5):589-92 [12708903] Ann Intern Med. 2001 Jun 19;134(12):1124-9 [11412053] JAMA. 2001 Apr 4;285(13):1736-45 [11277828] Comment In: Ann Intern Med. 2011 May 3;154(9):642; author reply 643 [21536943] Ann Intern Med. 2011 May 3;154(9):642-3; author reply 643 [21536942] Ann Intern Med. 2010 Oct 5;153(7):477-9 [20921548] Summary For Patients In: Ann Intern Med. 2010 Oct 5;153(7):I48 [20921539] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.7326/0003-4819-153-7-201010050-00008 ER - TY - JOUR T1 - Gas/Particle Partitioning of Dioxins in Exhaust Gases from Automobiles AN - 954637715; 16402519 AB - This study investigates distributions of polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofiiran (PCDD/F) congeners in the exhaust gases of gasoline- and diesel-fueled vehicles. 6 sport utility vehicles (SUVs), 6 diesel passenger vehicles (DPVs), and 3 heavy duty diesel vehicle (HDDV) were examined using chassis dynamometer tests for measuring vehicular dioxin emissions. The mean PCDD/F I-TEQ emission factors were 0.101, 0.0688 and 0.912 ng I-TEQ/km for the SUVs, DPVs and HDDV, respectively. Highly chlorinated congeners dominated both gaseous and paniculate phase PCDD/Fs. The major contributors of gas-phase PCDD/F I-TEQ for the SUVs, DPVs, and HDDV were 2,3,4,7,8-PeCDF, 2,3,7,8-TeCDD, and 2,3,4,7,8-PeCDF, respectively; however, 2,3,4,7,8-PeCDF was the major contributor in particulate-phase PCDD/F I-TEQ of these vehicles. The particulate-phase PCDD/Fs was responsible for 78.0, 90.3 and 71.1% of total PCDD/Fs for the SUVs, DPVs, and HDDV, respectively. Therefore, the control of particulate matter is more critical than that of gaseous pollutants for reducing PCDD/F emissions from automobiles. JF - Aerosol and Air Quality Resarch AU - Chuang, S-C AU - Chen, S-J AU - Huang, K-L AU - Wu, EM-Y AU - Chang-Chien, G-P AU - Wang, L-C AD - Department of Environmental Engineering and Science, National Pingtung University of Science and Technology, 1 Shieh-Fu Rd, Nei Pu 91207, Pingtung, Taiwan Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 489 EP - 496 VL - 10 IS - 5 SN - 1680-8584, 1680-8584 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Aerosols KW - Air quality KW - Atmospheric pollution KW - Atmospheric pollution by diesel engines KW - Atmospheric pollution by motor vehicles KW - Diesel engines KW - Dioxins KW - Emissions KW - Exhaust emissions KW - Gaseous pollutants KW - Motor vehicles KW - PCDD KW - Particulate matter emissions KW - Particulates KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954637715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aerosol+and+Air+Quality+Resarch&rft.atitle=Gas%2FParticle+Partitioning+of+Dioxins+in+Exhaust+Gases+from+Automobiles&rft.au=Chuang%2C+S-C%3BChen%2C+S-J%3BHuang%2C+K-L%3BWu%2C+EM-Y%3BChang-Chien%2C+G-P%3BWang%2C+L-C&rft.aulast=Chuang&rft.aufirst=S-C&rft.date=2010-10-01&rft.volume=10&rft.issue=5&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=Aerosol+and+Air+Quality+Resarch&rft.issn=16808584&rft_id=info:doi/10.4209%2Faaqr.2010.04.0028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-09-10 N1 - SubjectsTermNotLitGenreText - Atmospheric pollution by diesel engines; Atmospheric pollution; Particulate matter emissions; Gaseous pollutants; Air quality; Atmospheric pollution by motor vehicles; Aerosols; Motor vehicles; Emissions; Particulates; Diesel engines; Dioxins; PCDD; Exhaust emissions DO - http://dx.doi.org/10.4209/aaqr.2010.04.0028 ER - TY - JOUR T1 - A Nutrient Approach to Prostate Cancer Prevention: The Selenium and Vitamin E Cancer Prevention Trial (SELECT) AN - 954608965; 14061447 AB - The Selenium and Vitamin E Cancer Prevention Trial (SELECT) randomized 35,533 healthy men, >55 yr old (>50 yr if African American), with normal digital rectal exams and prostate specific antigens <4 ng/ml to 1) 200 mu g/day l-selenomethionine, 2) 400 IU/day all-rac-alpha-tocopheryl acetate (vitamin E), 3) both supplements, or 4) placebo for 7 to 12 yr. The hypotheses underlying SELECT, that selenium and vitamin E individually and together decrease prostate cancer incidence, derived from epidemiologic and laboratory evidence and significant secondary endpoints in the Nutritional Prevention of Cancer (selenium) and Alpha-Tocopherol Beta-Carotene (vitamin E) trials. In SELECT, prostate cancer incidence did not differ among the 4 arms: hazard ratios [99% confidence intervals (CIs)] for prostate cancer were 1.13 (99% CI = 0.95-1.35, P = 0.06; n = 473) for vitamin E, 1.04 (99% CI = 0.87-1.24, P = 0.62; n = 432) for selenium, and 1.05 (99% CI = 0.88-1.25, P = 0.52; n = 437) for selenium + vitamin E vs. 1.00 (n = 416) for placebo. Statistically nonsignificant increased risks of prostate cancer with vitamin E alone [relative risk (RR) = 1.13, P = 0.06) and newly diagnosed Type 2 diabetes mellitus with selenium alone (RR = 1.07, P = 0.16) were observed. SELECT data show that neither selenium nor vitamin E, alone or together, in the doses and formulations used, prevented prostate cancer in this heterogeneous population of healthy men. JF - Nutrition and Cancer AU - Dunn, Barbara K AU - Richmond, Ellen S AU - Minasian, Lori M AU - Ryan, Anne M AU - Ford, Leslie G AD - Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, USA Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 896 EP - 918 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 62 IS - 7 SN - 0163-5581, 0163-5581 KW - Risk Abstracts KW - Selenium KW - diabetes mellitus KW - vitamins KW - prevention KW - prostate cancer KW - Cancer KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954608965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nutrition+and+Cancer&rft.atitle=A+Nutrient+Approach+to+Prostate+Cancer+Prevention%3A+The+Selenium+and+Vitamin+E+Cancer+Prevention+Trial+%28SELECT%29&rft.au=Dunn%2C+Barbara+K%3BRichmond%2C+Ellen+S%3BMinasian%2C+Lori+M%3BRyan%2C+Anne+M%3BFord%2C+Leslie+G&rft.aulast=Dunn&rft.aufirst=Barbara&rft.date=2010-10-01&rft.volume=62&rft.issue=7&rft.spage=896&rft.isbn=&rft.btitle=&rft.title=Nutrition+and+Cancer&rft.issn=01635581&rft_id=info:doi/10.1080%2F01635581.2010.509833 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Number of references - 150 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Selenium; diabetes mellitus; vitamins; prevention; prostate cancer; Ethnic groups; Cancer DO - http://dx.doi.org/10.1080/01635581.2010.509833 ER - TY - JOUR T1 - Training Outcomes from the Samaritans of New York Suicide Awareness and Prevention Programme among Community- and School-Based Staff AN - 954599537; 14310363 AB - The Samaritans of New York public education suicide awareness and prevention programme is designed to train lay and professional staff on effective suicide prevention practices and how to 'befriend' a person in crisis. However, little is known about the individual-level characteristics of staff who attend these trainings. Community- and school-based staff (N = 365) completed pre- and post-training measures of self-efficacy regarding their knowledge about suicide and suicide prevention and their ability to intervene with individuals at risk for suicide. Results indicate increased self-efficacy after suicide prevention training (M = 3.7, SD = 0.6) than before (M = 3.3, SD = 0.7) (t = -13.24, p < 0.05). Trainees with higher levels of education and previous contact with suicidal individuals were significantly more likely to indicate gains in self-efficacy after training. JF - British Journal of Social Work AU - Clark, Tanisha R AU - Matthieu, Monica M AU - Ross, Alan AU - Knox, Kerry L AD - Tanisha R. Clark has a BA from Spelman College in Atlanta, Georgia, majoring in psychology, and was an NIMH undergraduate research fellow through Atlanta University Center NIMH-Career Opportunities in Research (AUC NIMH-COR). Ms Clark served as a Research Assistant at the Center for Mental Health Services Research at the George Warren Brown School of Social Work, Washington University in St Louis and the Department of Veterans Affairs Medical Center in St Louis, Missouri, as part of her summer research experience for AUC NIMH-COR. Monica M. Matthieu, Ph.D., LCSW, is a Research Assistant Professor at the George Warren Brown School of Social Work, Washington University in St Louis, and a Research Social Worker at the Department of Veterans Affairs Medical Center in St Louis, Missouri. Alan Ross, M.A., is the Executive Director of the Samaritans of New York, Inc., New York, NY. Kerry L. Knox, Ph.D., is an Associate Professor in the Department of Psychiatry, University of Rochester, mmatthieu@wustl.edu Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 2223 EP - 2238 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 40 IS - 7 SN - 0045-3102, 0045-3102 KW - Risk Abstracts KW - Education KW - Training KW - crises KW - prevention KW - suicide KW - USA, New York KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954599537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Social+Work&rft.atitle=Training+Outcomes+from+the+Samaritans+of+New+York+Suicide+Awareness+and+Prevention+Programme+among+Community-+and+School-Based+Staff&rft.au=Clark%2C+Tanisha+R%3BMatthieu%2C+Monica+M%3BRoss%2C+Alan%3BKnox%2C+Kerry+L&rft.aulast=Clark&rft.aufirst=Tanisha&rft.date=2010-10-01&rft.volume=40&rft.issue=7&rft.spage=2223&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Social+Work&rft.issn=00453102&rft_id=info:doi/10.1093%2Fbjsw%2Fbcq016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Education; Training; crises; prevention; suicide; USA, New York DO - http://dx.doi.org/10.1093/bjsw/bcq016 ER - TY - JOUR T1 - Study of brain anatomy with high-field MRI: recent progress AN - 954589690; 13943848 AB - Recent developments in high-field magnetic resonance imaging technology have led to improved contrast and resolution and are opening up new possibilities for the study of human brain anatomy. In particular, techniques sensitized to magnetic susceptibility contrast provide particular advantages at high field that have allowed visualization of brain structures that have been difficult to detect with conventional technology. In this review, some of these developments and techniques will be discussed, and an attempt will be made to interpret magnetic susceptibility contrast based on recent studies. JF - Magnetic Resonance Imaging AU - Duyn, Jozef H AD - Laboratory for Advanced MRI, LFMI, NINDS, National Institutes of Health, Bethesda, MD 20892, USA, jhd@helix.nih.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 1210 EP - 1215 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 28 IS - 8 SN - 0730-725X, 0730-725X KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain KW - Magnetic resonance imaging KW - W 30910:Imaging KW - N3:11029 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954589690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=Study+of+brain+anatomy+with+high-field+MRI%3A+recent+progress&rft.au=Duyn%2C+Jozef+H&rft.aulast=Duyn&rft.aufirst=Jozef&rft.date=2010-10-01&rft.volume=28&rft.issue=8&rft.spage=1210&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2010.02.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.mri.2010.02.007 ER - TY - JOUR T1 - Clinical Trials for predictive medicine: new challenges and paradigms AN - 954576545; 13855138 AB - Background Developments in biotechnology and genomics have increased the focus of biostatisticians on prediction problems. This has led to many exciting developments for predictive modeling where the number of variables is larger than the number of cases. Heterogeneity of human diseases and new technology for characterizing them presents new opportunities and challenges for the design and analysis of Clinical Trials.Purpose In oncology, treatment of broad populations with regimens that do not benefit most patients is less economically sustainable with expensive molecularly targeted therapeutics. The established molecular heterogeneity of human diseases requires the development of new paradigms for the design and analysis of randomized Clinical Trials as a reliable basis for predictive medicine [Simon R. An agenda for Clinical Trials: Clinical Trials in the genomic era. Clin Trials 2004; 1:468--70, Simon R. New challenges for 21st century Clinical Trials. Clin Trials 2007; 4: 167--9.]. Results We have reviewed prospective designs for the development of new therapeutics with candidate predictive biomarkers. We have also outlined a prediction based approach to the analysis of randomized Clinical Trials that both preserves the type I error and provides a reliable internally validated basis for predicting which patients are most likely or unlikely to benefit from the new regimen. Conclusions Developing new treatments with predictive biomarkers for identifying the patients who are most likely or least likely to benefit makes drug development more complex. But for many new oncology drugs it is the only science based approach and should increase the chance of success. It may also lead to more consistency in results among trials and has obvious benefits for reducing the number of patients who ultimately receive expensive drugs which expose them risks of adverse events but no benefit. This approach also has great potential value for controlling societal expenditures on health care. Development of treatments with predictive biomarkers requires major changes in the standard paradigms for the design and analysis of Clinical Trials. Some of the key assumptions upon which current methods are based are no longer valid. In addition to reviewing a variety of new clinical trial designs for co-development of treatments and predictive biomarkers, we have outlined a prediction based approach to the analysis of randomized Clinical Trials. This is a very structured approach whose use requires careful prospective planning. It requires further development but may serve as a basis for a new generation of predictive Clinical Trials which provide the kinds of reliable individualized information which physicians and patients have long sought, but which have not been available from the past use of post-hoc subset analysis. Clinical Trials 2010; 7: 516--524. http://ctj.sagepub.com JF - Clinical Trials AU - Simon, Richard AD - Biometric Research Branch, National Cancer Institute, Bethesda, MD, USA, rsimon@nih.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 516 EP - 524 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 7 IS - 5 SN - 1740-7745, 1740-7745 KW - Risk Abstracts KW - Bioindicators KW - clinical trials KW - Health care KW - prediction models KW - Reviews KW - Drugs KW - Biotechnology KW - Side effects KW - Technology KW - R2 23040:Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954576545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Trials&rft.atitle=Clinical+Trials+for+predictive+medicine%3A+new+challenges+and+paradigms&rft.au=Simon%2C+Richard&rft.aulast=Simon&rft.aufirst=Richard&rft.date=2010-10-01&rft.volume=7&rft.issue=5&rft.spage=516&rft.isbn=&rft.btitle=&rft.title=Clinical+Trials&rft.issn=17407745&rft_id=info:doi/10.1177%2F1740774510366454 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Bioindicators; Health care; prediction models; Reviews; clinical trials; Drugs; Side effects; Biotechnology; Technology DO - http://dx.doi.org/10.1177/1740774510366454 ER - TY - JOUR T1 - Blood transfusions and the subsequent risk of hematologic malignancies AN - 954573312; 13818881 AB - BACKGROUND: Blood transfusions are associated with viral transmission and immunomodulation, perhaps increasing subsequent risk of hematologic malignancies (HMs). Prior studies of transfusion recipients have lacked details on specific HM subtypes.STUDY DESIGN AND METHODS: JF - Transfusion AU - Chang, Cindy M AU - Quinlan, Scott C AU - Warren, Joan L AU - Engels, Eric A AD - From the Division of Cancer Epidemiology and Genetics, National Cancer Institute, and the Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, Maryland. Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 2249 EP - 2257 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 50 IS - 10 SN - 0041-1132, 0041-1132 KW - Risk Abstracts KW - transfusion KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954573312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Blood+transfusions+and+the+subsequent+risk+of+hematologic+malignancies&rft.au=Chang%2C+Cindy+M%3BQuinlan%2C+Scott+C%3BWarren%2C+Joan+L%3BEngels%2C+Eric+A&rft.aulast=Chang&rft.aufirst=Cindy&rft.date=2010-10-01&rft.volume=50&rft.issue=10&rft.spage=2249&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2010.02692.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - transfusion DO - http://dx.doi.org/10.1111/j.1537-2995.2010.02692.x ER - TY - JOUR T1 - Secretion of a bacterial virulence factor is driven by the folding of a C-terminal segment AN - 918042260; 14771773 AB - Autotransporters are bacterial virulence factors consisting of an N-terminal 'passenger domaina that is secreted in a C- to-N-terminal direction and a C-terminal ' beta domaina that resides in the outer membrane (OM). Although passenger domain secretion does not appear to use ATP, the energy source for this reaction is unknown. Here, we show that efficient secretion of the passenger domain of the Escherichia coli O157:H7 autotransporter EspP requires the stable folding of a C-terminal similar to 17-kDa passenger domain segment. We found that mutations that perturb the folding of this segment do not affect its translocation across the OM but impair the secretion of the remainder of the passenger domain. Interestingly, an examination of kinetic folding mutants strongly suggested that the similar to 17-kDa segment folds in the extracellular space. By mutagenizing the similar to 17-kDa segment, we also fortuitously isolated a unique translocation intermediate. Analysis of this intermediate suggests that a heterooligomer that facilitates the membrane integration of OM proteins (the Bam complex) also promotes the surface exposure of the similar to 17-kDa segment. Our results provide direct evidence that protein folding can drive translocation and help to clarify the mechanism of autotransporter secretion. JF - Proceedings of the National Academy of Sciences, USA AU - Peterson, Janine H AU - Tian, Pu AU - Ieva, Raffaele AU - Dautin, Nathalie AU - Bernstein, Harris D AD - Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 17739 EP - 17744 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 107 IS - 41 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - ATP KW - Energy KW - Energy sources KW - Integration KW - Kinetics KW - Membranes KW - Mutants KW - Mutation KW - Outer membranes KW - Protein folding KW - Protein transport KW - Proteins KW - Secretion KW - Translocation KW - translocation KW - virulence factors KW - Escherichia coli KW - J 02310:Genetics & Taxonomy KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918042260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Secretion+of+a+bacterial+virulence+factor+is+driven+by+the+folding+of+a+C-terminal+segment&rft.au=Peterson%2C+Janine+H%3BTian%2C+Pu%3BIeva%2C+Raffaele%3BDautin%2C+Nathalie%3BBernstein%2C+Harris+D&rft.aulast=Peterson&rft.aufirst=Janine&rft.date=2010-10-01&rft.volume=107&rft.issue=41&rft.spage=17739&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.1009491107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2013-01-25 N1 - SubjectsTermNotLitGenreText - Protein transport; Integration; Protein folding; virulence factors; Energy; Kinetics; Secretion; Outer membranes; ATP; Mutation; Translocation; Membranes; Proteins; translocation; Energy sources; Mutants; Escherichia coli DO - http://dx.doi.org/10.1073/pnas.1009491107 ER - TY - JOUR T1 - Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia AN - 918042258; 14771772 AB - Salmonella enterica is an intracellular bacterial pathogen that resides and proliferates within a membrane-bound vacuole in epithelial cells of the gut and gallbladder. Although essential to disease, how Salmonella escapes from its intracellular niche and spreads to secondary cells within the same host, or to a new host, is not known. Here, we demonstrate that a subpopulation of Salmonella hyperreplicating in the cytosol of epithelial cells serves as a reservoir for dissemination. These bacteria are transcriptionally distinct from intravacuolar Salmonella. They are induced for the invasion-associated type III secretion system and possess flagella; hence, they are primed for invasion. Epithelial cells laden with these cytosolic bacteria are extruded out of the monolayer, releasing invasion-primed and -competent Salmonella into the lumen. This extrusion mechanism is morphologically similar to the process of cell shedding required for turnover of the intestinal epithelium. In contrast to the homeostatic mechanism, however, bacterial-induced extrusion is accompanied by an inflammatory cell death characterized by caspase-1 activation and the apical release of IL-18, an important cytokine regulator of gut inflammation. Although epithelial extrusion is obviously beneficial to Salmonella for completion of its life cycle, it also provides a mechanistic explanation for the mucosal inflammation that is triggered during Salmonella infection of the gastrointestinal and biliary tracts. JF - Proceedings of the National Academy of Sciences, USA AU - Knodler, Leigh A AU - Vallance, Bruce A AU - Celli, Jean AU - Winfree, Seth AU - Hansen, Bryan AU - Montero, Marinieve AU - Steele-Mortimer, Olivia AD - Laboratory of Intracellular Parasites and Research Technologies Branch, Microscopy Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840 Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 17733 EP - 17738 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 107 IS - 41 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Biliary tract KW - Caspase-1 KW - Cell death KW - Cytosol KW - Digestive tract KW - Epithelial cells KW - Epithelium KW - Flagella KW - Gallbladder KW - Infection KW - Inflammation KW - Interleukin 18 KW - Intestine KW - Life cycle KW - Mucosa KW - Pathogens KW - Transcription KW - Vacuoles KW - Bacteria KW - Salmonella enterica KW - A 01490:Miscellaneous KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918042258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Dissemination+of+invasive+Salmonella+via+bacterial-induced+extrusion+of+mucosal+epithelia&rft.au=Knodler%2C+Leigh+A%3BVallance%2C+Bruce+A%3BCelli%2C+Jean%3BWinfree%2C+Seth%3BHansen%2C+Bryan%3BMontero%2C+Marinieve%3BSteele-Mortimer%2C+Olivia&rft.aulast=Knodler&rft.aufirst=Leigh&rft.date=2010-10-01&rft.volume=107&rft.issue=41&rft.spage=17733&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.1006098107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2013-01-25 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Mucosa; Transcription; Life cycle; Pathogens; Infection; Biliary tract; Inflammation; Gallbladder; Cell death; Digestive tract; Vacuoles; Interleukin 18; Intestine; Cytosol; Caspase-1; Epithelium; Flagella; Bacteria; Salmonella enterica DO - http://dx.doi.org/10.1073/pnas.1006098107 ER - TY - JOUR T1 - Umbilical Cord Monitoring of In Utero Drug Exposure to Buprenorphine and Correlation with Maternal Dose and Neonatal Outcomes AN - 902376640; 15813610 AB - Buprenorphine is under investigation in the U.S. as pharmacotherapy for opioid-dependent pregnant women. Buprenorphine and metabolites were quantified in umbilical cord specimens from women receiving daily buprenorphine doses. Correlations between maternal buprenorphine dose, buprenorphine and metabolite umbilical cord concentrations, and neonatal outcomes were investigated, as well as the ability to identify heroin and cocaine relapse during pregnancy. Umbilical cord concentrations were compared to those of matched umbilical cord plasma and meconium. Buprenorphine metabolites were detected in all cords, but buprenorphine itself was absent. Concentration ranges were 1.2-5.1 ng/g norbuprenorphine, 1.7-4.2 ng/g buprenorphine-glucuronide, and 8.3-23 ng/g norbuprenorphine-glucuronide. Cord concentrations were similar to those in plasma, and lower (16-210-fold), although statistically correlated, than those in meconium. Significant positive correlations were observed for buprenorphine-glucuronide concentrations in umbilical cord and mean maternal BUP daily dose throughout pregnancy and third trimester, but buprenorphine biomarker concentrations did not predict neonatal outcomes. Opiate concentrations were lower (200-fold) in umbilical cord than in meconium, and when cocaine was present in meconium, it was not identified in cord. Umbilical cord can serve as an alternative matrix for identifying prenatal drug-exposure, but is much less sensitive than meconium. Buprenorphine provided a controlled drug administration model for evaluating drug disposition in the maternal-fetal dyad. JF - Journal of Analytical Toxicology AU - Concheiro, Marta AU - Jones, Hendre E AU - Johnson, Rolley E AU - Choo, Robin AU - Shakleya, Diaa M AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA; Departamento Anatom?a Patol?gica y Ciencias Forenses, Universidad de Santiago de Compostela, Santiago de Compostela, Spain Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 498 EP - 505 PB - Preston Publications, Inc., 6600 W. Touhy Ave. Niles IL 60714 United States VL - 34 IS - 8 SN - 0146-4760, 0146-4760 KW - Toxicology Abstracts KW - Opiates KW - Heroin KW - Drug development KW - Metabolites KW - Meconium KW - Disposition KW - Intrauterine exposure KW - Drug abuse KW - biomarkers KW - Umbilical cord KW - Models KW - Pregnancy KW - Buprenorphine KW - Neonates KW - Cocaine KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902376640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=Umbilical+Cord+Monitoring+of+In+Utero+Drug+Exposure+to+Buprenorphine+and+Correlation+with+Maternal+Dose+and+Neonatal+Outcomes&rft.au=Concheiro%2C+Marta%3BJones%2C+Hendre+E%3BJohnson%2C+Rolley+E%3BChoo%2C+Robin%3BShakleya%2C+Diaa+M%3BHuestis%2C+Marilyn+A&rft.aulast=Concheiro&rft.aufirst=Marta&rft.date=2010-10-01&rft.volume=34&rft.issue=8&rft.spage=498&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ L2 - http://www.ingentaconnect.com/content/pres/jat/2010/00000034/00000008/art00009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Opiates; Heroin; Disposition; Meconium; Metabolites; Drug development; Intrauterine exposure; Drug abuse; biomarkers; Umbilical cord; Pregnancy; Models; Buprenorphine; Neonates; Cocaine ER - TY - JOUR T1 - 5% Dimethyl sulfoxide (DMSO) and pentastarch improves cryopreservation of cord blood cells over 10% DMSO AN - 899135849; 13818887 AB - BACKGROUND: Cell number and viability are important in cord blood (CB) transplantation. While 10% dimethyl sulfoxide (DMSO) is the standard medium, adding a starch to freezing medium is increasingly utilized as a cytoprotectant for the thawing process. Similar to hetastarch, pentastarch has the advantages of faster renal clearance and less effect on the coagulation system.STUDY DESIGN AND METHODS: JF - Transfusion AU - Hayakawa, Jun AU - Joyal, Elizabeth G AU - Gildner, Jean F AU - Washington, Kareem N AU - Phang, Oswald A AU - Uchida, Naoya AU - Hsieh, Matthew M AU - Tisdale, John F AD - From the Molecular and Clinical Hematology Branch (MCHB); the National Institutes of Diabetes and Digestive and Kidney Disorders (NIDDK); the National Heart, Lung, and Blood Institute (NHLBI); and the Charles S. Carter Cellular Therapy Laboratory, Department of Transfusion Medicine, National Institutes of Health, Bethesda, Maryland. Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 2158 EP - 2166 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 50 IS - 10 SN - 0041-1132, 0041-1132 KW - Biotechnology and Bioengineering Abstracts KW - Cord blood KW - Cell number KW - Coagulation KW - Dimethyl sulfoxide KW - Kidney KW - Freezing KW - Starch KW - Cryopreservation KW - Thawing KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899135849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=5%25+Dimethyl+sulfoxide+%28DMSO%29+and+pentastarch+improves+cryopreservation+of+cord+blood+cells+over+10%25+DMSO&rft.au=Hayakawa%2C+Jun%3BJoyal%2C+Elizabeth+G%3BGildner%2C+Jean+F%3BWashington%2C+Kareem+N%3BPhang%2C+Oswald+A%3BUchida%2C+Naoya%3BHsieh%2C+Matthew+M%3BTisdale%2C+John+F&rft.aulast=Hayakawa&rft.aufirst=Jun&rft.date=2010-10-01&rft.volume=50&rft.issue=10&rft.spage=2158&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2010.02684.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Cord blood; Coagulation; Cell number; Freezing; Kidney; Dimethyl sulfoxide; Starch; Cryopreservation; Thawing DO - http://dx.doi.org/10.1111/j.1537-2995.2010.02684.x ER - TY - JOUR T1 - The Diesel Exhaust in Miners Study: I. Overview of the Exposure Assessment Process AN - 899129078; 13842722 AB - This report provides an overview of the exposure assessment process for an epidemiologic study that investigated mortality, with a special focus on lung cancer, associated with diesel exhaust (DE) exposure among miners. Details of several components are provided in four other reports. A major challenge for this study was the development of quantitative estimates of historical exposures to DE. There is no single standard method for assessing the totality of DE, so respirable elemental carbon (REC), a component of DE, was selected as the primary surrogate in this study. Air monitoring surveys at seven of the eight study mining facilities were conducted between 1998 and 2001 and provided reference personal REC exposure levels and measurements for other agents and DE components in the mining environment. (The eighth facility had closed permanently prior to the surveys.) Exposure estimates were developed for mining facility/department/job/year combinations. A hierarchical grouping strategy was developed for assigning exposure levels to underground jobs [based on job titles, on the amount of time spent in various areas of the underground mine, and on similar carbon monoxide (CO, another DE component) concentrations] and to surface jobs (based on the use of, or proximity to, diesel-powered equipment). Time trends in air concentrations for underground jobs were estimated from mining facility-specific prediction models using diesel equipment horsepower, total air flow rates exhausted from the underground mines, and, because there were no historical REC measurements, historical measurements of CO. Exposures to potentially confounding agents, i.e. respirable dust, silica, radon, asbestos, and non-diesel sources of polycyclic aromatic hydrocarbons, also were assessed. Accuracy and reliability of the estimated REC exposures levels were evaluated by comparison with several smaller datasets and by development of alternative time trend models. During 1998-2001, the average measured REC exposure level by facility ranged from 40 to 384 kg m-3 for the underground workers and from 2 to 6 kg m-3 for the surface workers. For one prevalent underground job, 'miner operator', the maximum annual REC exposure estimate by facility ranged up to 685% greater than the corresponding 1998-2001 value. A comparison of the historical CO estimates from the time trend models with 1976-1977 CO measurements not used in the modeling found an overall median relative difference of 29%. Other comparisons showed similar levels of agreement. The assessment process indicated large differences in REC exposure levels over time and across the underground operations. Method evaluations indicated that the final estimates were consistent with those from alternative time trend models and demonstrated moderate to high agreement with external data. JF - Annals of Occupational Hygiene AU - Stewart, Patricia A AU - Coble, Joseph B AU - Vermeulen, Roel AU - Schleiff, Patricia AU - Blair, Aaron AU - Lubin, Jay AU - Attfield, Michael AU - Silverman, Debra T AD - Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, 20892 MD, USA Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 728 EP - 746 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 54 IS - 7 SN - 0003-4878, 0003-4878 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Occupational safety KW - Dust KW - Models KW - Carbon monoxide KW - air flow KW - Occupational exposure KW - Exhaust emissions KW - Air flow KW - Lung cancer KW - Mortality KW - Asbestos KW - Polycyclic aromatic hydrocarbons KW - Data processing KW - Mines KW - Radon KW - Exhausts KW - Silica KW - Reviews KW - Diesel KW - Mining KW - Diesel engines KW - X 24360:Metals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899129078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=The+Diesel+Exhaust+in+Miners+Study%3A+I.+Overview+of+the+Exposure+Assessment+Process&rft.au=Stewart%2C+Patricia+A%3BCoble%2C+Joseph+B%3BVermeulen%2C+Roel%3BSchleiff%2C+Patricia%3BBlair%2C+Aaron%3BLubin%2C+Jay%3BAttfield%2C+Michael%3BSilverman%2C+Debra+T&rft.aulast=Stewart&rft.aufirst=Patricia&rft.date=2010-10-01&rft.volume=54&rft.issue=7&rft.spage=728&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mortality; Polycyclic aromatic hydrocarbons; Asbestos; Data processing; Mines; Radon; Dust; Models; Exhausts; Carbon monoxide; Silica; Reviews; Diesel; Occupational exposure; Lung cancer; Air flow; air flow; Historical account; Occupational safety; Mining; Diesel engines; Exhaust emissions ER - TY - JOUR T1 - The Diesel Exhaust in Miners Study: II. Exposure Monitoring Surveys and Development of Exposure Groups AN - 899129075; 13842720 AB - Air monitoring surveys were conducted between 1998 and 2001 at seven non-metal mining facilities to assess exposure to respirable elemental carbon (REC), a component of diesel exhaust (DE), for an epidemiologic study of miners exposed to DE. Personal exposure measurements were taken on workers in a cross-section of jobs located underground and on the surface. Air samples taken to measure REC were also analyzed for respirable organic carbon (ROC). Concurrent measurements to assess exposure to nitric oxide (NO) and nitrogen dioxide (NO2), two gaseous components of DE, were also taken. The REC measurements were used to develop quantitative estimates of average exposure levels by facility, department, and job title for the epidemiologic analysis. Each underground job was assigned to one of three sets of exposure groups from specific to general: (i) standardized job titles, (ii) groups of standardized job titles combined based on the percentage of time in the major underground areas, and (iii) larger groups based on similar area carbon monoxide (CO) air concentrations. Surface jobs were categorized based on their use of diesel equipment and proximity to DE. A total of 779 full-shift personal measurements were taken underground. The average REC exposure levels for underground jobs with five or more measurements ranged from 31 to 58 kg m-3 at the facility with the lowest average exposure levels and from 313 to 488 kg m-3 at the facility with the highest average exposure levels. The average REC exposure levels for surface workers ranged from 2 to 6 kg m-3 across the seven facilities. There was much less contrast in the ROC compared with REC exposure levels measured between surface and underground workers within each facility, as well as across the facilities. The average ROC levels underground ranged from 64 to 195 kg m-3, while on the surface, the average ROC levels ranged from 38 to 71 kg m-3 by facility, an 62- to 3-fold difference. The average NO and NO2 levels underground ranged from 0.20 to 1.49 parts per million (ppm) and from 0.10 to 0.60 ppm, respectively, and were 610 times higher than levels on the surface, which ranged from 0.02 to 0.11 ppm and from 0.01 to 0.06 ppm, respectively. The ROC, NO, and NO2 concentrations underground were correlated with the REC levels (r = 0.62, 0.71, and 0.62, respectively). A total of 80% of the underground jobs were assigned an exposure estimate based on measurements taken for the specific job title or for other jobs with a similar percentage of time spent in the major underground work areas. The average REC exposure levels by facility were from 15 to 64 times higher underground than on the surface. The large contrast in exposure levels measured underground versus on the surface, along with the differences between the mining facilities and between underground jobs within the facilities resulted in a wide distribution in the exposure estimates for evaluation of exposure-response relationships in the epidemiologic analyses. JF - Annals of Occupational Hygiene AU - Coble, Joseph B AU - Stewart, Patricia A AU - Vermeulen, Roel AU - Yereb, Daniel AU - Stanevich, Rebecca AU - Blair, Aaron AU - Silverman, Debra T AU - Attfield, Michael AD - Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, 20892 MD, USA Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 747 EP - 761 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 54 IS - 7 SN - 0003-4878, 0003-4878 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Pollution monitoring KW - Occupational safety KW - Nitrogen dioxide KW - Carbon monoxide KW - Carbon KW - Dose-response effects KW - Occupational exposure KW - Exhaust emissions KW - Exhausts KW - Standards KW - Nitric oxide KW - Diesel KW - Mining KW - Diesel engines KW - X 24360:Metals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899129075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=The+Diesel+Exhaust+in+Miners+Study%3A+II.+Exposure+Monitoring+Surveys+and+Development+of+Exposure+Groups&rft.au=Coble%2C+Joseph+B%3BStewart%2C+Patricia+A%3BVermeulen%2C+Roel%3BYereb%2C+Daniel%3BStanevich%2C+Rebecca%3BBlair%2C+Aaron%3BSilverman%2C+Debra+T%3BAttfield%2C+Michael&rft.aulast=Coble&rft.aufirst=Joseph&rft.date=2010-10-01&rft.volume=54&rft.issue=7&rft.spage=747&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Carbon monoxide; Nitrogen dioxide; Dose-response effects; Diesel; Nitric oxide; Mining; Occupational exposure; Exhausts; Pollution monitoring; Carbon; Occupational safety; Standards; Diesel engines; Exhaust emissions ER - TY - JOUR T1 - The Diesel Exhaust in Miners Study: III. Interrelations between Respirable Elemental Carbon and Gaseous and Particulate Components of Diesel Exhaust derived from Area Sampling in Underground Non-metal Mining Facilities AN - 899129072; 13842719 AB - Diesel exhaust (DE) has been implicated as a potential lung carcinogen. However, the exact components of DE that might be involved have not been clearly identified. In the past, nitrogen oxides (NOx) and carbon oxides (COx) were measured most frequently to estimate DE, but since the 1990s, the most commonly accepted surrogate for DE has been elemental carbon (EC). We developed quantitative estimates of historical exposure levels of respirable elemental carbon (REC) for an epidemiologic study of mortality, particularly lung cancer, among diesel-exposed miners by back-extrapolating 1998-2001 REC exposure levels using historical measurements of carbon monoxide (CO). The choice of CO was based on the availability of historical measurement data. Here, we evaluated the relationship of REC with CO and other current and historical components of DE from side-by-side area measurements taken in underground operations of seven non-metal mining facilities. The Pearson correlation coefficient of the natural log-transformed (Ln)REC measurements with the Ln(CO) measurements was 0.4. The correlation of REC with the other gaseous, organic carbon (OC), and particulate measurements ranged from 0.3 to 0.8. Factor analyses indicated that the gaseous components, including CO, together with REC, loaded most strongly on a presumed 'Diesel exhaust' factor, while the OC and particulate agents loaded predominantly on other factors. In addition, the relationship between Ln(REC) and Ln(CO) was approximately linear over a wide range of REC concentrations. The fact that CO correlated with REC, loaded on the same factor, and increased linearly in log-log space supported the use of CO in estimating historical exposure levels to DE. JF - Annals of Occupational Hygiene AU - Vermeulen, Roel AU - Coble, Joseph B AU - Yereb, Daniel AU - Lubin, Jay H AU - Blair, Aaron AU - Portengen, Luetzen AU - Stewart, Patricia A AU - Attfield, Michael AU - Silverman, Debra T AD - Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD, 20892 Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 762 EP - 773 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 54 IS - 7 SN - 0003-4878, 0003-4878 KW - Health & Safety Science Abstracts KW - Historical account KW - Occupational safety KW - Particulates KW - Carbon monoxide KW - Carbon KW - Photochemicals KW - Mining KW - Diesel engines KW - Exhaust emissions KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899129072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=The+Diesel+Exhaust+in+Miners+Study%3A+III.+Interrelations+between+Respirable+Elemental+Carbon+and+Gaseous+and+Particulate+Components+of+Diesel+Exhaust+derived+from+Area+Sampling+in+Underground+Non-metal+Mining+Facilities&rft.au=Vermeulen%2C+Roel%3BCoble%2C+Joseph+B%3BYereb%2C+Daniel%3BLubin%2C+Jay+H%3BBlair%2C+Aaron%3BPortengen%2C+Luetzen%3BStewart%2C+Patricia+A%3BAttfield%2C+Michael%3BSilverman%2C+Debra+T&rft.aulast=Vermeulen&rft.aufirst=Roel&rft.date=2010-10-01&rft.volume=54&rft.issue=7&rft.spage=762&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Carbon monoxide; Historical account; Photochemicals; Carbon; Occupational safety; Mining; Particulates; Diesel engines; Exhaust emissions ER - TY - JOUR T1 - Multiple imputation for estimating the risk of developing dementia and its impact on survival AN - 888109473; 15039050 AB - Dementia, Alzheimer's disease in particular, is one of the major causes of disability and decreased quality of life among the elderly and a leading obstacle to successful aging. Given the profound impact on public health, much research has focused on the age-specific risk of developing dementia and the impact on survival. Early work has discussed various methods of estimating age-specific incidence of dementia, among which the illness-death model is popular for modeling disease progression. In this article we use multiple imputation to fit multi-state models for survival data with interval censoring and left truncation. This approach allows semi-Markov models in which survival after dementia depends on onset age. Such models can be used to estimate the cumulative risk of developing dementia in the presence of the competing risk of dementia-free death. Simulations are carried out to examine the performance of the proposed method. Data from the Honolulu Asia Aging Study are analyzed to estimate the age-specific and cumulative risks of dementia and to examine the effect of major risk factors on dementia onset and death. JF - Biometrical Journal AU - Yu, Binbing AU - Saczynski, Jane S AU - Launer, Lenore AD - Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, MD 20892, USA, yubi@mail.nih.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 616 EP - 627 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 52 IS - 5 SN - 1521-4036, 1521-4036 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Aging KW - Alzheimer's disease KW - Biometrics KW - Data processing KW - Dementia disorders KW - Geriatrics KW - Models KW - Neurodegenerative diseases KW - Public health KW - Quality of life KW - Risk factors KW - Statistics KW - Survival KW - N3 11002:Computational & theoretical neuroscience KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888109473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=Multiple+imputation+for+estimating+the+risk+of+developing+dementia+and+its+impact+on+survival&rft.au=Yu%2C+Binbing%3BSaczynski%2C+Jane+S%3BLauner%2C+Lenore&rft.aulast=Yu&rft.aufirst=Binbing&rft.date=2010-10-01&rft.volume=52&rft.issue=5&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=15214036&rft_id=info:doi/10.1002%2Fbimj.200900266 L2 - http://onlinelibrary.wiley.com/doi/10.1002/bimj.200900266/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-12-14 N1 - SubjectsTermNotLitGenreText - Data processing; Statistics; Aging; Alzheimer's disease; Survival; Biometrics; Models; Public health; Neurodegenerative diseases; Risk factors; Dementia disorders; Geriatrics; Quality of life DO - http://dx.doi.org/10.1002/bimj.200900266 ER - TY - JOUR T1 - Somatic mosaicism in Menkes disease suggests choroid plexus-mediated copper transport to the developing brain AN - 879478806; 15130387 AB - The primary mechanism of copper transport to the brain is unknown, although this process is drastically impaired in Menkes disease, an X-linked neurodevelopmental disorder caused by mutations in an evolutionarily conserved copper transporter, ATP7A. Potential central nervous system entry routes for copper include brain capillary endothelial cells that originate from mesodermal angioblasts and form the blood-brain barrier, and the choroid plexuses, which derive from embryonic ectoderm, and form the blood-cerebrospinal fluid barrier. We exploited a rare (and first reported) example of somatic mosaicism for an ATP7A mutation to shed light on questions about copper transport into the developing brain. In a 20-month-old Menkes disease patient evaluated before copper treatment, blood copper, and catecholamine concentrations were normal, whereas levels in cerebrospinal fluid were abnormal and consistent with his neurologically severe phenotype. We documented disparate levels of mosaicism for an ATP7A missense mutation, P1001L, in tissues derived from different embryonic origins; allele quantitation showed P1001L in approximately 27% of DNA samples from blood cells (mesoderm-derived) and 88% from cultured fibroblasts (ectoderm-derived). These findings imply that the P1001L mutation in the patient preceded formation of the three primary embryonic lineages at gastrulation, with the ectoderm layer ultimately harboring a higher percentage of mutation-bearing cells than mesoderm or endoderm. Since choroid plexus epithelia are derived from neuroectoderm, and brain capillary endothelial cells from mesodermal angioblasts, the clinical and biochemical findings in this infant support a critical role for the blood-CSF barrier (choroid plexus epithelia) in copper entry to the developing brain. 2010 Wiley-Liss, Inc. JF - American Journal of Medical Genetics Part A AU - Donsante, Anthony AU - Johnson, Paul AU - Jansen, Laura A AU - Kaler, Stephen G AD - Unit on Human Copper Metabolism, Molecular Medicine Program, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, kalers@mail.nih.gov Y1 - 2010/10/01/ PY - 2010 DA - 2010 Oct 01 SP - 2529 EP - 2534 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 152A IS - 10 SN - 1552-4833, 1552-4833 KW - Genetics Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Blood cells KW - Blood-brain barrier KW - Catecholamines KW - Central nervous system KW - Cerebrospinal fluid KW - Choroid plexus KW - Copper KW - DNA KW - Ectoderm KW - Embryos KW - Endoderm KW - Endothelial cells KW - Evolution KW - Fibroblasts KW - Gastrulation KW - Infants KW - Menkes disease KW - Mesoderm KW - Missense mutation KW - Mosaicism KW - Neurodevelopmental disorders KW - Neuroectoderm KW - Quantitation KW - X chromosome KW - N3 11003:Developmental neuroscience KW - X 24360:Metals KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879478806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Medical+Genetics+Part+A&rft.atitle=Somatic+mosaicism+in+Menkes+disease+suggests+choroid+plexus-mediated+copper+transport+to+the+developing+brain&rft.au=Donsante%2C+Anthony%3BJohnson%2C+Paul%3BJansen%2C+Laura+A%3BKaler%2C+Stephen+G&rft.aulast=Donsante&rft.aufirst=Anthony&rft.date=2010-10-01&rft.volume=152A&rft.issue=10&rft.spage=2529&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Medical+Genetics+Part+A&rft.issn=15524833&rft_id=info:doi/10.1002%2Fajmg.a.33632 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-09-10 N1 - SubjectsTermNotLitGenreText - Neurodevelopmental disorders; Central nervous system; Missense mutation; Gastrulation; Blood-brain barrier; Ectoderm; X chromosome; Neuroectoderm; Copper; Choroid plexus; Mesoderm; Fibroblasts; Endothelial cells; Cerebrospinal fluid; Catecholamines; Mosaicism; Menkes disease; DNA; Endoderm; Embryos; Blood cells; Quantitation; Evolution; Infants DO - http://dx.doi.org/10.1002/ajmg.a.33632 ER - TY - JOUR T1 - Models of carcinogenesis: an overview AN - 876244216; 14086714 AB - At least five coherent models of carcinogenesis have been proposed in the history of cancer research in the last century. Model 1 is mainly centered around mutations, and its main focus is on the chemical environment, radiation and viruses. Model 2 has to do mainly with genome instability and it focuses on familiality. Model 3 is based on non-genotoxic mechanisms, and clonal expansion and epigenetics are its main features. We propose a fourth model, which can encompass the previous three, based on the concept of a 'Darwinian' cell selection (we clarify that the term Darwinian needs to be used cautiously, being a short cut for 'somatic cellular selection'). Finally, a fifth model has recently become popular, based on the concept of 'tissue organization'. We describe examples of the five models and how they have been formalized mathematically. The five models largely overlap, both scientifically and historically, but for the sake of clarity, it is useful to treat them separately. We also argue that the five models can be included into a simpler scheme, i.e. two types of models: (i) biological changes in the epithelium alone lead to malignancy and (ii) changes in stroma/extracellular matrix are necessary (along with changes in epithelium) for malignancy. Our description, though simplified, looks realistic, it is able to capture the historical sequence of carcinogenesis theories in the last century and can serve as a frame to make research hypotheses more explicit. JF - Carcinogenesis AU - Vineis, Paolo AU - Schatzkin, Arthur AU - Potter, John D AD - 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20886, USA, p.vineis@imperial.ac.uk Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 1703 EP - 1709 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 31 IS - 10 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - Stroma KW - Genomes KW - Mathematical models KW - Cancer KW - Malignancy KW - Radiation KW - epigenetics KW - Extracellular matrix KW - Sake KW - Reviews KW - Carcinogenesis KW - Epithelium KW - Mutation KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876244216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Models+of+carcinogenesis%3A+an+overview&rft.au=Vineis%2C+Paolo%3BSchatzkin%2C+Arthur%3BPotter%2C+John+D&rft.aulast=Vineis&rft.aufirst=Paolo&rft.date=2010-10-01&rft.volume=31&rft.issue=10&rft.spage=1703&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgq087 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Genomes; Stroma; Mathematical models; Cancer; Malignancy; Radiation; epigenetics; Reviews; Sake; Extracellular matrix; Carcinogenesis; Epithelium; Mutation DO - http://dx.doi.org/10.1093/carcin/bgq087 ER - TY - JOUR T1 - Leupaxin is similar to paxillin in focal adhesion targeting and tyrosine phosphorylation but has distinct roles in cell adhesion and spreading. AN - 862792410; 20543562 AB - Focal adhesion (FA) formation is induced by extracellular matrix-stimulated integrin clustering and activation of receptors for diffusible factors. Leupaxin (LPXN) is a member of the paxillin family of FA proteins expressed in many cancer cell lines. We found activation of gastrin-releasing peptide receptor (GRPr) by bombesin (BN) stimulated LPXN translocation from cytoplasm to FAs. Using mutagenesis, we identified LIM3 as the primary FA targeting domain for LPXN and showed BN-induced LPXN tyrosine phosphorylation on residues 22, 62 and 72. A LIM3 point mutant of LPXN failed to target to FAs and had no BN-stimulated tyrosine phosphorylation. Conversely, a non-phosphorylatable mutant (Y22/62/72F) translocated to FAs after BN addition. Stimulation of FA formation using vinblastine also induced LPXN translocation and tyrosine phosphorylation. Therefore, dynamic LPXN tyrosine phosphorylation requires translocation to FAs. LPXN and paxillin had opposite roles in adhesion to collagen I (CNI) in MDA-MB-231 breast cancer cells. LPXN siRNA stimulated whereas paxillin siRNA inhibited cell adhesion. Knockdown of both LPXN and paxillin behaved similarly to paxillin knockdown alone, suggesting LPXN’s function in adhesion might depend on paxillin. Additionally, LPXN regulated cell spreading on CNI but not on fibronectin whereas paxillin knockdown suppressed spreading on both substrates. These results demonstrate that although LPXN and paxillin’s FA targeting and tyrosine phosphorylation are similar, each protein has distinct functions. JF - Cell adhesion & migration AU - Chen, Pei-Wen AU - Kroog, Glenn S AD - Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA. chenp2@mail.nih.gov PY - 2010 SP - 527 EP - 540 VL - 4 IS - 4 KW - Cell Adhesion Molecules KW - 0 KW - Collagen Type I KW - Extracellular Matrix Proteins KW - LPXN protein, human KW - Paxillin KW - Phosphoproteins KW - Recombinant Fusion Proteins KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Tyrosine KW - 42HK56048U KW - Bombesin KW - PX9AZU7QPK KW - Index Medicus KW - Animals KW - Cricetulus KW - Humans KW - Mice KW - Amino Acid Sequence KW - Cell Line, Tumor KW - Green Fluorescent Proteins -- genetics KW - Recombinant Fusion Proteins -- metabolism KW - Collagen Type I -- metabolism KW - Phosphorylation KW - BALB 3T3 Cells KW - Recombinant Fusion Proteins -- genetics KW - CHO Cells KW - Bombesin -- pharmacology KW - RNA Interference KW - Protein Structure, Tertiary KW - Green Fluorescent Proteins -- metabolism KW - Sequence Deletion KW - Protein Transport KW - Cricetinae KW - Cell Adhesion Molecules -- genetics KW - Phosphoproteins -- genetics KW - Extracellular Matrix Proteins -- metabolism KW - Cell Adhesion -- physiology KW - Cell Adhesion Molecules -- metabolism KW - Cell Adhesion -- genetics KW - Paxillin -- genetics KW - Tyrosine -- metabolism KW - Focal Adhesions -- metabolism KW - Paxillin -- metabolism KW - Phosphoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862792410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+adhesion+%26+migration&rft.atitle=Leupaxin+is+similar+to+paxillin+in+focal+adhesion+targeting+and+tyrosine+phosphorylation+but+has+distinct+roles+in+cell+adhesion+and+spreading.&rft.au=Chen%2C+Pei-Wen%3BKroog%2C+Glenn+S&rft.aulast=Chen&rft.aufirst=Pei-Wen&rft.date=2010-10-01&rft.volume=4&rft.issue=4&rft.spage=527&rft.isbn=&rft.btitle=&rft.title=Cell+adhesion+%26+migration&rft.issn=1933-6926&rft_id=info:doi/10.4161%2Fcam.4.4.12399 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-21 N1 - Date created - 2011-04-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1999 Apr 2;274(14):9847-53 [10092676] Curr Biol. 1999 Jun 17;9(12):640-8 [10375527] Nat Biotechnol. 2005 Jan;23(1):94-101 [15592455] J Cell Sci. 2007 Jan 1;120(Pt 1):137-48 [17164291] Am J Physiol Cell Physiol. 2007 Jun;292(6):C2288-96 [17329398] Breast Cancer Res Treat. 2007 Jul;104(1):13-9 [17004106] J Biol Chem. 2007 Sep 14;282(37):27181-91 [17640867] J Cell Physiol. 2008 Mar;214(3):655-61 [17786945] Mol Endocrinol. 2008 Jul;22(7):1606-21 [18451096] Cancer Sci. 2010 Feb;101(2):363-8 [19917054] Annu Rev Pharmacol Toxicol. 2002;42:283-323 [11807174] Int J Biochem Cell Biol. 2002 Jul;34(7):855-63 [11950600] Cell. 2002 Sep 20;110(6):673-87 [12297042] J Cell Sci. 2003 Mar 15;116(Pt 6):975-86 [12584242] J Bone Miner Res. 2003 Apr;18(4):669-85 [12674328] J Cell Sci. 2003 Aug 15;116(Pt 16):3269-76 [12857786] J Biol Chem. 2003 Aug 1;278(31):28743-9 [12771155] Mol Pharmacol. 2003 Oct;64(4):890-904 [14500746] Anal Chem. 2004 May 15;76(10):2763-72 [15144186] J Cell Biol. 2004 Jul 19;166(2):283-95 [15263022] Physiol Rev. 2004 Oct;84(4):1315-39 [15383653] Clin Immunol Immunopathol. 1985 Dec;37(3):387-96 [2414046] Annu Rev Cell Biol. 1988;4:487-525 [3058164] Cancer. 1989 May 1;63(9):1714-20 [2539244] Nature. 1999 Dec 9;402(6762):676-81 [10604475] Nat Genet. 2000 Mar;24(3):227-35 [10700174] Nat Cell Biol. 2000 Apr;2(4):191-6 [10783236] J Biol Chem. 2000 Jul 21;275(29):21785-8 [10801897] J Biol Chem. 2000 Sep 29;275(39):30644-52 [10880515] Exp Cell Res. 2001 Jun 10;266(2):292-302 [11399057] Mol Cell Biol. 2001 Aug;21(16):5332-45 [11463817] J Biol Chem. 2001 Oct 5;276(40):37086-92 [11477105] Biochem J. 2001 Nov 15;360(Pt 1):57-66 [11695992] J Cell Sci. 2001 Oct;114(Pt 20):3583-90 [11707510] Mol Cell Biol. 2002 Feb;22(3):901-15 [11784865] Oncogene. 2002 Jan 3;21(1):96-107 [11791180] Mol Cell Biol. 2005 May;25(9):3763-73 [15831480] J Biol Chem. 2005 Jun 24;280(25):23516-22 [15817476] Nat Methods. 2005 Aug;2(8):591-8 [16094384] Nucleic Acids Res. 1991 Jan 11;19(1):85-92 [2011514] Immunology. 1991 Jun;73(2):205-11 [1649124] Cell. 1992 Aug 7;70(3):389-99 [1643657] Cell. 1992 Aug 7;70(3):401-10 [1643658] J Biol Chem. 1993 Oct 15;268(29):22060-5 [8408063] J Biol Chem. 1994 Mar 25;269(12):9345-51 [7510708] Regul Pept. 1994 Jan 13;49(3):185-93 [8140272] Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10655-9 [7938009] FEBS Lett. 1994 Nov 14;354(3):315-9 [7525357] J Biol Chem. 1995 Apr 7;270(14):8217-24 [7713928] Cell. 1995 Apr 7;81(1):53-62 [7536630] Med Res Rev. 1995 Sep;15(5):389-417 [8531502] Annu Rev Cell Dev Biol. 1995;11:379-416 [8689563] Annu Rev Cell Dev Biol. 1995;11:549-99 [8689569] J Cell Biol. 1996 Nov;135(4):1109-23 [8922390] Curr Biol. 1996 Oct 1;6(10):1279-89 [8939572] Cell Struct Funct. 1996 Oct;21(5):317-26 [9118237] Biochem J. 1997 Jul 15;325 ( Pt 2):375-81 [9230116] Nucleic Acids Res. 1997 Aug 15;25(16):3371-2 [9241254] Mol Biol Cell. 1997 Aug;8(8):1415-25 [9285815] J Biol Chem. 1998 Jan 9;273(2):1003-14 [9422762] J Biol Chem. 1998 May 8;273(19):11709-13 [9565592] J Biol Chem. 1998 Jun 5;273(23):14626-32 [9603980] Mol Biol Cell. 1998 Jul;9(7):1803-16 [9658172] Int J Cancer. 1998 Aug 31;77(5):778-86 [9688313] J Biol Chem. 1998 Oct 9;273(41):26516-21 [9756887] Cell Adhes Commun. 1998 Jun;5(4):249-55 [9762466] Oncogene. 1999 Jan 7;18(1):67-77 [9926921] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4161/cam.4.4.12399 ER - TY - JOUR T1 - Chronic and Acute Effects of Coal Tar Pitch Exposure and Cardiopulmonary Mortality Among Aluminum Smelter Workers AN - 856759975; 13849221 AB - Air pollution causes several adverse cardiovascular and respiratory effects. In occupational studies, where levels of particulate matter and polycyclic aromatic hydrocarbons (PAHs) are higher, the evidence is inconsistent. The effects of acute and chronic PAH exposure on cardiopulmonary mortality were examined within a Kitimat, Canada, aluminum smelter cohort (n = 7,026) linked to a national mortality database (1957-1999). No standardized mortality ratio was significantly elevated compared with the province's population. Smoking-adjusted internal comparisons were conducted using Cox regression for male subjects (n = 6,423). Ischemic heart disease (IHD) mortality (n = 281) was associated with cumulative benzo[a]pyrene (B(a)P) exposure (hazard ratio = 1.62, 95% confidence interval: 1.06, 2.46) in the highest category. A monotonic but nonsignificant trend was observed with chronic B(a)P exposure and acute myocardial infarction (n = 184). When follow-up was restricted to active employment, the hazard ratio for IHD was 2.39 (95% confidence interval: 0.95, 6.05) in the highest cumulative B(a)P category. The stronger associations observed during employment suggest that risk may not persist after exposure cessation. No associations with recent or current exposure were observed. IHD was associated with chronic (but not current) PAH exposure in a high-exposure occupational setting. Given the widespread workplace exposure to PAHs and heart disease's high prevalence, even modest associations produce a high burden. JF - American Journal of Epidemiology AU - Friesen, Melissa C AU - Demers, Paul A AU - Spinelli, John J AU - Eisen, Ellen A AU - Lorenzi, Maria F AU - Le, Nhu D Y1 - 2010/10/01/ PY - 2010 DA - 2010 Oct 01 SP - 790 EP - 799 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 172 IS - 7 SN - 0002-9262, 0002-9262 KW - Toxicology Abstracts; Physical Education Index; Risk Abstracts; Pollution Abstracts KW - air pollutants KW - cohort studies KW - heart diseases KW - occupational diseases KW - polycyclic hydrocarbons, aromatic KW - Death KW - employment KW - Particulate matter KW - Coal KW - Employment KW - Acute effects KW - Cardiorespiratory KW - Occupational exposure KW - Heart diseases KW - Mortality KW - Polycyclic aromatic hydrocarbons KW - Tar KW - Ischemia KW - Smelters KW - Myocardial infarction KW - Air pollution KW - Databases KW - Canada KW - Epidemiology KW - Aluminum KW - Standards KW - Benzo(a)pyrene KW - Mining KW - Trends KW - P 0000:AIR POLLUTION KW - X 24360:Metals KW - R2 23050:Environment KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856759975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Chronic+and+Acute+Effects+of+Coal+Tar+Pitch+Exposure+and+Cardiopulmonary+Mortality+Among+Aluminum+Smelter+Workers&rft.au=Friesen%2C+Melissa+C%3BDemers%2C+Paul+A%3BSpinelli%2C+John+J%3BEisen%2C+Ellen+A%3BLorenzi%2C+Maria+F%3BLe%2C+Nhu+D&rft.aulast=Friesen&rft.aufirst=Melissa&rft.date=2010-10-01&rft.volume=172&rft.issue=7&rft.spage=790&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwq208 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Air pollution; Death; Epidemiology; Cardiorespiratory; Employment; Trends; Heart diseases; Mortality; Polycyclic aromatic hydrocarbons; Tar; Particulate matter; Coal; Ischemia; Smelters; Myocardial infarction; Acute effects; Databases; Aluminum; Benzo(a)pyrene; Occupational exposure; employment; Standards; Mining; heart diseases; Canada DO - http://dx.doi.org/10.1093/aje/kwq208 ER - TY - JOUR T1 - Alcoholic Beverages and Prostate Cancer in a Prospective US Cohort Study AN - 856759935; 13849217 AB - Despite numerous investigations, the correlation between alcohol consumption and prostate cancer risk remains uncertain. This report investigated the association between alcohol use and prostate cancer risk in a prospective cohort study of 294,707 US men aged 50-71 years in 1995-1996. Cox proportional hazards regression models with hazard ratios and 95% confidence intervals were adjusted for characteristics including age, race, body mass index, physical activity, and family history of prostate cancer, as well as testing for prostate-specific antigen and a digital rectal examination. There were 15,327 nonadvanced and 1,900 advanced prostate cancers identified through 2003 and 514 fatal cases through 2005. Risk of nonadvanced prostate cancer was 25% higher for men consuming .6 drinks daily (hazard ratio = 1.25, 95% confidence interval: 1.13, 1.37), 19% higher for men consuming 3-60% of respondents). The authors observed no association between alcohol intake and advanced prostate cancer and an inverse association with fatal prostate cancer among heavy drinkers. These findings suggest that higher alcohol consumption modestly increases nonadvanced prostate cancer risk. JF - American Journal of Epidemiology AU - Watters, Joanne L AU - Park, Yikyung AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Albanes, Demetrius Y1 - 2010/10/01/ PY - 2010 DA - 2010 Oct 01 SP - 773 EP - 780 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 172 IS - 7 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - Alcohol KW - Genetics KW - Smoking KW - USA KW - Age KW - body mass KW - prostate cancer KW - physical activity KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856759935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Alcoholic+Beverages+and+Prostate+Cancer+in+a+Prospective+US+Cohort+Study&rft.au=Watters%2C+Joanne+L%3BPark%2C+Yikyung%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BAlbanes%2C+Demetrius&rft.aulast=Watters&rft.aufirst=Joanne&rft.date=2010-10-01&rft.volume=172&rft.issue=7&rft.spage=773&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwq200 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2013-11-04 N1 - SubjectsTermNotLitGenreText - Smoking; Genetics; Alcohol; Age; body mass; physical activity; prostate cancer; USA DO - http://dx.doi.org/10.1093/aje/kwq200 ER - TY - JOUR T1 - Evolution of diverse cell division and vesicle formation systems in Archaea AN - 853479098; 13725536 AB - Recently a novel cell division system comprised of homologues of eukaryotic ESCRT-III (endosomal sorting complex required for transport III) proteins was discovered in the hyperthermophilic crenarchaeote Sulfolobus acidocaldarius. On the basis of this discovery, we undertook a comparative genomic analysis of the machineries for cell division and vesicle formation in Archaea. Archaea possess at least three distinct membrane remodelling systems: the FtsZ-based bacterial-type system, the ESCRT-III-based eukaryote-like system and a putative novel system that uses an archaeal actin-related protein. Many archaeal genomes encode assortments of components from different systems. Evolutionary reconstruction from these findings suggests that the last common ancestor of the extant Archaea possessed a complex membrane remodelling apparatus, different components of which were lost during subsequent evolution of archaeal lineages. By contrast, eukaryotes seem to have inherited all three ancestral systems. JF - Nature Reviews: Microbiology AU - Makarova, Kira S AU - Yutin, Natalya AU - Bell, Stephen D AU - Koonin, Eugene V AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA. Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 731 EP - 741 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 8 IS - 10 SN - 1740-1526, 1740-1526 KW - Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources KW - Genomes KW - Cell division KW - Archaea KW - Genomic analysis KW - Microbiology KW - Sulfolobus acidocaldarius KW - Vesicles KW - Evolution KW - Q1 08205:Genetics and evolution KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853479098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Microbiology&rft.atitle=Evolution+of+diverse+cell+division+and+vesicle+formation+systems+in+Archaea&rft.au=Makarova%2C+Kira+S%3BYutin%2C+Natalya%3BBell%2C+Stephen+D%3BKoonin%2C+Eugene+V&rft.aulast=Makarova&rft.aufirst=Kira&rft.date=2010-10-01&rft.volume=8&rft.issue=10&rft.spage=731&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Microbiology&rft.issn=17401526&rft_id=info:doi/10.1038%2Fnrmicro2406 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Genomes; Cell division; Microbiology; Genomic analysis; Vesicles; Evolution; Archaea; Sulfolobus acidocaldarius DO - http://dx.doi.org/10.1038/nrmicro2406 ER - TY - JOUR T1 - Toxic Bodies: Hormone Disruptors and the Legacy of DES AN - 849440211; 13969404 AB - Abstract not available. JF - Environmental Health Perspectives AU - Newbold, Retha R AD - Retha R. Newbold is a developmental reproductive biologist working at the National Institute of Environmental Health Sciences for 37 years until retirement in 2009. Early in her career, she developed a mouse model to study prenatal effects of DES, which proved useful in replicating and predicting adverse effects in humans. She continues to use this model to study other endocrine disrupting chemicals. Newbold is the author of more than 200 publications in the field Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - A452 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 118 IS - 10 SN - 0091-6765, 0091-6765 KW - Environment Abstracts; Pollution Abstracts KW - Hormones KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849440211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Toxic+Bodies%3A+Hormone+Disruptors+and+the+Legacy+of+DES&rft.au=Newbold%2C+Retha+R&rft.aulast=Newbold&rft.aufirst=Retha&rft.date=2010-10-01&rft.volume=118&rft.issue=10&rft.spage=A452&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Hormones ER - TY - JOUR T1 - Evaluation of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Identification of Clinically Important Yeast Species AN - 839684078; 13810938 AB - We evaluated the use of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) for the rapid identification of yeast species. Using Bruker Daltonics MALDI BioTyper software, we created a spectral database library with m/z ratios of 2,000 to 20,000 Da for 109 type and reference strains of yeast (44 species in 8 genera). The database was tested for accuracy by use of 194 clinical isolates (23 species in 6 genera). A total of 192 (99.0%) of the clinical isolates were identified accurately by MALDI-TOF MS. The MALDI-TOF MS-based method was found to be reproducible and accurate, with low consumable costs and minimal preparation time. JF - Journal of Clinical Microbiology AU - Stevenson, Lindsay G AU - Drake, Steven K AU - Shea, Yvonne R AU - Zelazny, Adrian M AU - Murray, Patrick R AD - Microbiology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, Pmurray@cc.nih.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 3482 EP - 3486 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 48 IS - 10 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Toxicology Abstracts KW - Clinical isolates KW - Databases KW - Computer programs KW - software KW - Lasers KW - Mass spectroscopy KW - X 24390:Radioactive Materials KW - K 03300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839684078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Evaluation+of+Matrix-Assisted+Laser+Desorption+Ionization-Time+of+Flight+Mass+Spectrometry+for+Identification+of+Clinically+Important+Yeast+Species&rft.au=Stevenson%2C+Lindsay+G%3BDrake%2C+Steven+K%3BShea%2C+Yvonne+R%3BZelazny%2C+Adrian+M%3BMurray%2C+Patrick+R&rft.aulast=Stevenson&rft.aufirst=Lindsay&rft.date=2010-10-01&rft.volume=48&rft.issue=10&rft.spage=3482&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00687-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Number of references - 29 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Computer programs; Databases; software; Lasers; Mass spectroscopy DO - http://dx.doi.org/10.1128/JCM.00687-09 ER - TY - JOUR T1 - Identification of Alpha Interferon-Induced Genes Associated with Antiviral Activity in Daudi Cells and Characterization of IFIT3 as a Novel Antiviral Gene AN - 839682729; 13971339 AB - A novel assay was developed for Daudi cells in which the antiviral (AV) and antiproliferative (AP) activities of interferon (IFN) can be measured simultaneously. Using this novel assay, conditions allowing IFN AV protection but no growth inhibition were identified and selected. Daudi cells were treated under these conditions, and gene expression microarray analyses were performed. The results of the analysis identified 25 genes associated with IFN- AV activity. Upregulation of 23 IFN-induced genes was confirmed by using reverse transcription-PCR. Of 25 gene products, 17 were detected by Western blotting at 24 h. Of the 25 genes, 10 have not been previously linked to AV activity of IFN-. The most upregulated gene was IFIT3 (for IFN-induced protein with tetratricopeptide repeats 3). The results from antibody neutralizing experiments suggested an association of the identified genes with IFN- AV activity. This association was strengthened by results from IFIT3-small interfering RNA transfection experiments showing decreased expression of IFIT3 and a reduction in the AV activity induced by IFN-. Overexpression of IFIT3 resulted in a decrease of virus titer. Transcription of AV genes after the treatment of cells with higher concentrations of IFN having an AP effect on Daudi cells suggested pleiotropic functions of identified gene products. JF - Journal of Virology AU - Schmeisser, H AU - Mejido, J AU - Balinsky, CA AU - Morrow, AN AU - Clark, C R AU - Zhao, T AU - Zoon, K C AD - National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, kzoon@niaid.nih.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 10671 EP - 10680 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 84 IS - 20 SN - 0022-538X, 0022-538X KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Interferon KW - Western blotting KW - Antibodies KW - RNA KW - Transfection KW - Transcription KW - Antiviral activity KW - DNA microarrays KW - A 01340:Antibiotics & Antimicrobials KW - G 07880:Human Genetics KW - V 22300:Methods KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839682729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Identification+of+Alpha+Interferon-Induced+Genes+Associated+with+Antiviral+Activity+in+Daudi+Cells+and+Characterization+of+IFIT3+as+a+Novel+Antiviral+Gene&rft.au=Schmeisser%2C+H%3BMejido%2C+J%3BBalinsky%2C+CA%3BMorrow%2C+AN%3BClark%2C+C+R%3BZhao%2C+T%3BZoon%2C+K+C&rft.aulast=Schmeisser&rft.aufirst=H&rft.date=2010-10-01&rft.volume=84&rft.issue=20&rft.spage=10671&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.00818-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Number of references - 41 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Western blotting; Interferon; Antibodies; RNA; Transfection; Transcription; Antiviral activity; DNA microarrays DO - http://dx.doi.org/10.1128/JVI.00818-10 ER - TY - JOUR T1 - Use of magnetically purified Plasmodium falciparum parasites improves the accuracy of erythrocyte invasion assays AN - 839652323; 13365818 AB - Merozoite invasion of erythrocytes is a crucial step for the asexual cycle of Plasmodium falciparum. Multiple invasion pathways, which involve different ligand-receptor interactions, have been identified in P. falciparum by examining the entry of purified parasite into erythrocytes with different surface receptors, either mutant or under different enzyme treatments. The most critical step for a successful invasion assay is the isolation of erythrocytes infected with viable schizonts. Here, we applied a magnetic column to purify the schizonts for the erythrocyte invasion assay. Comparing to Percoll-sorbitol purification method, this modified approach showed great improvement on reproducibility and reliability of invasion assay, particularly for short-term, culture-adapted parasite isolates. The magnetic purification method is an excellent alternative for parasite isolates that do not tolerate or with unknown sensitivity to Percoll-sorbitol exposure. JF - Experimental Parasitology AU - Bates, Adam H AU - Mu, Jianbing AU - Jiang, Hongying AU - Fairhurst, Rick M AU - Su, Xin-zhuan AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA, jmu@niaid.nih.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 278 EP - 280 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 126 IS - 2 SN - 0014-4894, 0014-4894 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources KW - Plasmodium falciparum KW - Parasite purification KW - Erythrocyte invasion KW - Magnetic column KW - Parasites KW - Erythrocytes KW - Receptors KW - Disease control KW - Schizonts KW - Enzymes KW - Merozoites KW - Purification KW - Q5 08524:Public health, medicines, dangerous organisms KW - Q1 08184:Reproduction and development KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839652323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+Parasitology&rft.atitle=Use+of+magnetically+purified+Plasmodium+falciparum+parasites+improves+the+accuracy+of+erythrocyte+invasion+assays&rft.au=Bates%2C+Adam+H%3BMu%2C+Jianbing%3BJiang%2C+Hongying%3BFairhurst%2C+Rick+M%3BSu%2C+Xin-zhuan&rft.aulast=Bates&rft.aufirst=Adam&rft.date=2010-10-01&rft.volume=126&rft.issue=2&rft.spage=278&rft.isbn=&rft.btitle=&rft.title=Experimental+Parasitology&rft.issn=00144894&rft_id=info:doi/10.1016%2Fj.exppara.2010.05.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2014-11-12 N1 - SubjectsTermNotLitGenreText - Parasites; Erythrocytes; Disease control; Receptors; Enzymes; Schizonts; Merozoites; Purification; Plasmodium falciparum DO - http://dx.doi.org/10.1016/j.exppara.2010.05.007 ER - TY - JOUR T1 - Assessment of Community Food Resources: A Latino Neighborhood Study in Upstate New York AN - 835114399; 201100324 AB - This study aims to assess availability, affordability, and accessibility of food items in a low-income Latino neighborhood within a small city using an on-site food store survey. Store locations were identified by on-site Global Positioning System. Results showed the Latino neighborhood had limited availability and above-average cost of high-fiber bread. Fresh vegetables were more expensive compared to the non-Latino neighborhood, and more stores in the Latino neighborhood participated in Supplemental Nutrition Assistance Food Program. The lack of supermarkets, fewer stores with disability access, and the lack of public transportation left Latino residents without a vehicle or with physical disabilities with few food shopping options. Adapted from the source document. JF - Journal of Poverty AU - Lopez-Class, Maria AU - Hosler, Akiko S AD - The National Institutes of Health, Bethesda, Maryland, USA Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 369 EP - 381 PB - Taylor & Francis, Philadelphia PA VL - 14 IS - 4 SN - 1087-5549, 1087-5549 KW - food environment Latino neighborhood nutrition access food cost supermarkets store survey KW - Cities KW - Physically Handicapped KW - Hispanic Americans KW - Neighborhoods KW - Public Transportation KW - Nutrition KW - article KW - 6141: poverty & homelessness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/835114399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Poverty&rft.atitle=Assessment+of+Community+Food+Resources%3A+A+Latino+Neighborhood+Study+in+Upstate+New+York&rft.au=Lopez-Class%2C+Maria%3BHosler%2C+Akiko+S&rft.aulast=Lopez-Class&rft.aufirst=Maria&rft.date=2010-10-01&rft.volume=14&rft.issue=4&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=Journal+of+Poverty&rft.issn=10875549&rft_id=info:doi/10.1080%2F10875549.2010.517070 LA - English DB - Social Services Abstracts N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-28 N1 - CODEN - JPOVF4 N1 - SubjectsTermNotLitGenreText - Neighborhoods; Hispanic Americans; Physically Handicapped; Cities; Nutrition; Public Transportation DO - http://dx.doi.org/10.1080/10875549.2010.517070 ER - TY - JOUR T1 - Literature Search and Review AN - 821737117; 14083357 AB - Parasitic weeds of the genera Striga and Orobanche are considered the most damaging agricultural agents in the developing world. An essential step in parasitic seed germination is sensing a group of structurally related compounds called strigolactones that are released by host plants. Although this makes strigolactone synthesis and action a major target of biotechnology, little fundamental information is known about this hormone. Chemical genetic screening using Arabidopsis thaliana as a platform identified a collection of related small molecules, cotylimides, which perturb strigolactone accumulation. Suppressor screens against select cotylimides identified light-signaling genes as positive regulators of strigolactone levels. Molecular analysis showed strigolactones regulate the nuclear localization of the COP1 ubiquitin ligase, which in part determines the levels of light regulators such as HY5. This information not only uncovers new functions for strigolactones but was also used to identify rice cultivars with reduced capacity to germinate parasitic seed. JF - Assay and Drug Development Technologies AU - Auld, D AU - Simeonov, A AU - Lea, W AU - Thomas, C AD - National Institutes of Health Bethesda, Maryland, USA Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 526 EP - 541 VL - 8 IS - 5 SN - 1540-658X, 1540-658X KW - Water Resources Abstracts; Aqualine Abstracts; Biotechnology and Bioengineering Abstracts KW - Weeds KW - Rice KW - Hormones KW - Ubiquitin-protein ligase KW - Arabidopsis thaliana KW - Seed germination KW - Assay KW - Genetic screening KW - Synthesis KW - Orobanche KW - Germination KW - Seeds KW - Oryza sativa KW - Drug development KW - Striga KW - Host plants KW - Light effects KW - Reviews KW - Accumulation KW - Biotechnology KW - SW 0540:Properties of water KW - AQ 00005:Underground Services and Water Use KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821737117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Assay+and+Drug+Development+Technologies&rft.atitle=Literature+Search+and+Review&rft.au=Auld%2C+D%3BSimeonov%2C+A%3BLea%2C+W%3BThomas%2C+C&rft.aulast=Auld&rft.aufirst=D&rft.date=2010-10-01&rft.volume=8&rft.issue=5&rft.spage=526&rft.isbn=&rft.btitle=&rft.title=Assay+and+Drug+Development+Technologies&rft.issn=1540658X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-12-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Weeds; Seeds; Reviews; Seed germination; Genetic screening; Drug development; Hormones; Host plants; Light effects; Ubiquitin-protein ligase; Germination; Rice; Assay; Synthesis; Accumulation; Biotechnology; Orobanche; Arabidopsis thaliana; Oryza sativa; Striga ER - TY - JOUR T1 - A Group IIC-Type Intron Interrupts the rRNA Methylase Gene of Geobacillus stearothermophilus Strain 10 AN - 817608499; 13971316 AB - Group IIC introns insert next to the stem-loop structure of rho-independent transcription terminators, thus avoiding intact genes. The insertion sites of 17 copies of the G.st.I1 intron from Geobacillus stearothermophilus were compared. One copy of the intron was found to interrupt an open reading frame (ORF) encoding an rRNA methylase. JF - Journal of Bacteriology AU - Moretz, Samuel E AU - Lampson, Bert C AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, Maryland 20852, Lampson@etsu.edu Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 5245 EP - 5248 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 192 IS - 19 SN - 0021-9193, 0021-9193 KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology KW - rRNA (adenosine-2'-0'-)-methyltransferase KW - Methylase KW - Genes KW - Introns KW - DNA KW - Transcription KW - Geobacillus KW - Strains KW - Open reading frames KW - Bacteriology KW - J 02310:Genetics & Taxonomy KW - Q1 08205:Genetics and evolution KW - N 14830:RNA KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/817608499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=A+Group+IIC-Type+Intron+Interrupts+the+rRNA+Methylase+Gene+of+Geobacillus+stearothermophilus+Strain+10&rft.au=Moretz%2C+Samuel+E%3BLampson%2C+Bert+C&rft.aulast=Moretz&rft.aufirst=Samuel&rft.date=2010-10-01&rft.volume=192&rft.issue=19&rft.spage=5245&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.00633-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-12-01 N1 - Number of references - 21 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Genes; DNA; Strains; Bacteriology; rRNA (adenosine-2'-0'-)-methyltransferase; Methylase; Introns; Transcription; Open reading frames; Geobacillus DO - http://dx.doi.org/10.1128/JB.00633-10 ER - TY - JOUR T1 - Biology of aging brain AN - 815541077; 13980940 AB - Normal aging of the nervous system is associated with some degree of decline in a number of cognitive functions. With the present day attempts to increase the life span, understanding the metabolic interactions and various mechanisms involved in normal neuronal aging continues to be a challenge. Loss of neurons is now recognized to be more modest than the initial estimates suggested and the loss only affected some of the specific neuroanatomical areas like hippocampus and prefrontal cortex. Individual neurons in addition show reduced size of dendritic and axonal arborization. Neurons have significant homeostatic control of the essential physiological functions like synaptic excitability, gene expression and metabolic regulation. Deviation in these normal events can have severe consequences as observed in aging and neurodegeneration. Based on experimental evidence, the evolution of aging is probably the result of altered metabolic triad: the mitochondria, reactive oxygen species and intracellular calcium homeostasis. Perturbations in the metabolic and functional state of this triad lead to a state of decreased homeostatic reserve, where the aged neurons still could maintain adequate function during normal activity. However, these neurons become vulnerable to the stress of excessive metabolic loads associated with spells of ischemia, trauma progressing to neuronal degeneration. Age-related neuronal dysfunction probably involves a host of subtle changes involving the synapses, receptors, neurotransmitters, cytological alterations, electrical transmission, leading to cognitive dysfunction. An exaggeration of it could be the clinical manifestation of dementia, with intraneuronal accumulation of protein aggregates deranging the metabolic state. This review deals with some of the structural, functiona and metabolic features of aging nervous system and discusses briefly the functional consequences. JF - Indian Journal of Pathology and Microbiology AU - Shankar, S K AD - Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore - 560 029, Karnataka, India Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 595 EP - 604 VL - 53 IS - 4 SN - 0377-4929, 0377-4929 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Age KW - Hippocampus KW - Aging KW - Mitochondria KW - Excitability KW - Neurodegeneration KW - Anatomy KW - Gene expression KW - Nervous system KW - Neurotransmission KW - Reactive oxygen species KW - Dementia disorders KW - Neurotransmitters KW - Brain architecture KW - Synapses KW - Life span KW - Brain KW - Stress KW - Ischemia KW - Calcium (intracellular) KW - Trauma KW - Cognitive ability KW - Cortex (prefrontal) KW - Evolution KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815541077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+Journal+of+Pathology+and+Microbiology&rft.atitle=Biology+of+aging+brain&rft.au=Shankar%2C+S+K&rft.aulast=Shankar&rft.aufirst=S&rft.date=2010-10-01&rft.volume=53&rft.issue=4&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Indian+Journal+of+Pathology+and+Microbiology&rft.issn=03774929&rft_id=info:doi/10.4103%2F0377-4929.71995 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Age; Synapses; Hippocampus; Aging; Life span; Brain; Stress; Mitochondria; Ischemia; Excitability; Neurodegeneration; Anatomy; Trauma; Calcium (intracellular); Gene expression; Nervous system; Reactive oxygen species; Neurotransmission; Cognitive ability; Dementia disorders; Neurotransmitters; Evolution; Cortex (prefrontal); Brain architecture DO - http://dx.doi.org/10.4103/0377-4929.71995 ER - TY - JOUR T1 - The Multifunctional PE_PGRS11 Protein from Mycobacterium tuberculosis Plays a Role in Regulating Resistance to Oxidative Stress AN - 807280310; 13813685 AB - Mycobacterium tuberculosis utilizes unique strategies to survive amid the hostile environment of infected host cells. Infection-specific expression of a unique mycobacterial cell surface antigen that could modulate key signaling cascades can act as a key survival strategy in curtailing host effector responses like oxidative stress. We demonstrate here that hypothetical PE_PGRS11 ORF encodes a functional phosphoglycerate mutase. The transcriptional analysis revealed that PE_PGRS11 is a hypoxia-responsive gene, and enforced expression of PE_PGRS11 by recombinant adenovirus or Mycobacterium smegmatis imparted resistance to alveolar epithelial cells against oxidative stress. PE_PGRS11-induced resistance to oxidative stress necessitated the modulation of genetic signatures like induced expression of Bcl2 or COX-2. This modulation of specific antiapoptotic molecular signatures involved recognition of PE_PGRS11 by TLR2 and subsequent activation of the PI3K-ERK1/2-NF-B signaling axis. Furthermore, PE_PGRS11 markedly diminished H2O2-induced p38 MAPK activation. Interestingly, PE_PGRS11 protein was exposed at the mycobacterial cell surface and was involved in survival of mycobacteria under oxidative stress. Furthermore, PE_PGRS11 displayed differential B cell responses during tuberculosis infection. Taken together, our investigation identified PE_PGRS11 as an in vivo expressed immunodominant antigen that plays a crucial role in modulating cellular life span restrictions imposed during oxidative stress by triggering TLR2-dependent expression of COX-2 and Bcl2. These observations clearly provide a mechanistic basis for the rescue of pathogenic Mycobacterium-infected lung epithelial cells from oxidative stress. JF - Journal of Biological Chemistry AU - Chaturvedi, Rashmi AU - Bansal, Kushagra AU - Narayana, Yeddula AU - Kapoor, Nisha AU - Sukumar, Namineni AU - Togarsimalemath, Shambhuprasad Kotresh AU - Chandra, Nagasuma AU - Mishra, Saurabh AU - Ajitkumar, Parthasarathi AU - Joshi, Beenu AU - Katoch, Vishwa Mohan AU - Patil, Shripad A AU - Balaji, Kithiganahalli N AD - From the Department of Microbiology and Cell Biology and Bioinformatics Centre, Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore 560012, India, National Jalma Institute of Leprosy and Other Mycobacterial Diseases, Tajganj, Agra 282001, India, and Department of Microbiology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India Y1 - 2010/10/01/ PY - 2010 DA - 2010 Oct 01 SP - 30389 EP - 30403 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 285 IS - 40 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Cyclooxygenase-2 KW - Cell survival KW - Epithelial cells KW - Cell surface KW - MAP kinase KW - Lymphocytes B KW - TLR2 protein KW - Adenovirus KW - Transcription KW - Infection KW - Alveoli KW - Mycobacterium smegmatis KW - Oxidative stress KW - Lung KW - Tuberculosis KW - Phosphoglycerate mutase KW - Open reading frames KW - Toll-like receptors KW - Mycobacterium tuberculosis KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807280310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=The+Multifunctional+PE_PGRS11+Protein+from+Mycobacterium+tuberculosis+Plays+a+Role+in+Regulating+Resistance+to+Oxidative+Stress&rft.au=Chaturvedi%2C+Rashmi%3BBansal%2C+Kushagra%3BNarayana%2C+Yeddula%3BKapoor%2C+Nisha%3BSukumar%2C+Namineni%3BTogarsimalemath%2C+Shambhuprasad+Kotresh%3BChandra%2C+Nagasuma%3BMishra%2C+Saurabh%3BAjitkumar%2C+Parthasarathi%3BJoshi%2C+Beenu%3BKatoch%2C+Vishwa+Mohan%3BPatil%2C+Shripad+A%3BBalaji%2C+Kithiganahalli+N&rft.aulast=Chaturvedi&rft.aufirst=Rashmi&rft.date=2010-10-01&rft.volume=285&rft.issue=40&rft.spage=30389&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Cell survival; Cyclooxygenase-2; Cell surface; Epithelial cells; MAP kinase; Lymphocytes B; TLR2 protein; Transcription; Infection; Alveoli; Lung; Oxidative stress; Tuberculosis; Phosphoglycerate mutase; Toll-like receptors; Open reading frames; Adenovirus; Mycobacterium tuberculosis; Mycobacterium smegmatis ER - TY - JOUR T1 - Parental Anxiety and Child Symptomatology: An Examination of Additive and Interactive Effects of Parent Psychopathology AN - 772262806; 201029709 AB - The current study examined relations between parent anxiety and child anxiety, depression, and externalizing symptoms. In addition, the study tested the additive and interactive effects of parent anxiety with parent depression and externalizing symptoms in relation to child symptoms. Forty-eight parents with anxiety disorders and 49 parents without any psychiatric disorder participated with one of their children (ages 6 to 14years; 46.4% male; 75.8% Caucasian). Parent anxiety was related to both child anxiety and depression, but not child externalizing symptoms. Hierarchical regression analyses showed that only parent externalizing symptoms had additive effects, beyond parent anxiety symptoms, in relation to child anxiety symptoms. Further, parent anxiety symptoms moderated the relationship between parent and child externalizing symptoms, such that the strength of this relationship was reduced in the presence of high levels of parent anxiety symptoms. Results of this study illuminate the role of parent comorbidity in understanding relations between parent and child symptoms. JF - Journal of Abnormal Child Psychology AU - Burstein, Marcy AU - Ginsburg, Golda S AU - Tein, Jenn-Yun AD - Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, 21287-3325, USA bursteinme@mail.nih.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 897 EP - 909 PB - Springer, Dordrecht The Netherlands VL - 38 IS - 7 SN - 0091-0627, 0091-0627 KW - Symptoms KW - Externalizing behaviour KW - Children KW - Parents KW - Additives KW - Anxiety-Depression KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/772262806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Abnormal+Child+Psychology&rft.atitle=Parental+Anxiety+and+Child+Symptomatology%3A+An+Examination+of+Additive+and+Interactive+Effects+of+Parent+Psychopathology&rft.au=Burstein%2C+Marcy%3BGinsburg%2C+Golda+S%3BTein%2C+Jenn-Yun&rft.aulast=Burstein&rft.aufirst=Marcy&rft.date=2010-10-01&rft.volume=38&rft.issue=7&rft.spage=897&rft.isbn=&rft.btitle=&rft.title=Journal+of+Abnormal+Child+Psychology&rft.issn=00910627&rft_id=info:doi/10.1007%2Fs10802-010-9415-0 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-11-11 N1 - Last updated - 2016-09-27 N1 - CODEN - JAPCAC N1 - SubjectsTermNotLitGenreText - Parents; Anxiety-Depression; Symptoms; Children; Externalizing behaviour; Additives DO - http://dx.doi.org/10.1007/s10802-010-9415-0 ER - TY - JOUR T1 - "The Cancer Bond": Exploring the Formation of Cancer Risk Perception in Families with Lynch Syndrome AN - 772252802; 201030595 AB - This study explores the social context of hereditary cancer risk perception in three families, an African-American family, a Mexican-American family, and a Caucasian family, each with Lynch Syndrome documented by a mismatch repair gene mutation. Communication network assessments measured family communication about cancer experiences and genetic testing information among a total of 26 participants. Participant narratives were evaluated to gain insight into how family cancer experiences and genetic testing information have shaped perceptions of cancer risk. Analysis of communication networks indicated that some families discussed cancer experiences to a greater extent than genetic testing information, and vice-versa. Interviews elucidated that sharing both types of health information led participants to conceptualize linkages among a strong family history of cancer, genetic testing information, and cancer prevention strategies. Understanding how different types of family communication influence the formation of perceived hereditary disease risk may enhance efforts to tailor genetic counseling services for families. Adapted from the source document. JF - Journal of Genetic Counseling AU - Palmquist, Aunchalee E L AU - Koehly, Laura M AU - Peterson, Susan K AU - Shegog, Margarette AU - Vernon, Sally W AU - Gritz, Ellen R AD - Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA aunchalee.palmquist@yale.edu Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 473 EP - 486 PB - Springer Science+Business Media, New York NY VL - 19 IS - 5 SN - 1059-7700, 1059-7700 KW - Mexican American people KW - Genetic screening KW - Repairs KW - Genetic family histories KW - Risk perception KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/772252802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Genetic+Counseling&rft.atitle=%22The+Cancer+Bond%22%3A+Exploring+the+Formation+of+Cancer+Risk+Perception+in+Families+with+Lynch+Syndrome&rft.au=Palmquist%2C+Aunchalee+E+L%3BKoehly%2C+Laura+M%3BPeterson%2C+Susan+K%3BShegog%2C+Margarette%3BVernon%2C+Sally+W%3BGritz%2C+Ellen+R&rft.aulast=Palmquist&rft.aufirst=Aunchalee+E&rft.date=2010-10-01&rft.volume=19&rft.issue=5&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=Journal+of+Genetic+Counseling&rft.issn=10597700&rft_id=info:doi/10.1007%2Fs10897-010-9299-8 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-11-11 N1 - Last updated - 2016-09-27 N1 - CODEN - JGCOET N1 - SubjectsTermNotLitGenreText - Cancer; Genetic screening; Risk perception; Genetic family histories; Repairs; Mexican American people DO - http://dx.doi.org/10.1007/s10897-010-9299-8 ER - TY - JOUR T1 - Single Custodial Fathers' Involvement and Parenting: Implications for Outcomes in Emerging Adulthood AN - 764426343; 201066347 AB - Using a sample of 3,977 youths from the National Longitudinal Survey of Youth (NLSY97), this study examines the unique characteristics of single-custodial-father families with adolescents and the effects of single fathers' involvement and parenting on outcomes in emerging adulthood. Findings suggest that single-custodial-father families are distinct from single-mother and 2-biological-parent families in terms of sociodemographic characteristics, parenting styles, and involvement. Parenting styles and involvement mediate the differences between single-father families and 2-parent families in terms of high school completion and disconnectedness and partially mediate differences for single-custodial-father families with a partner. Family and sociodemographic characteristics are also associated with being disconnected for adolescents residing with a cohabiting custodial father. Adapted from the source document. JF - Journal of Marriage and Family AU - Bronte-Tinkew, Jacinta AU - Scott, Mindy E AU - Lilja, Emily AD - National Institutes of Health jacinta.bronte-tinkew@nih.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 1107 EP - 1127 PB - Blackwell Publishers, Malden MA VL - 72 IS - 5 SN - 0022-2445, 0022-2445 KW - adolescents emerging adults parental involvement parenting styles single-parent families KW - Family KW - Life Stage Transitions KW - Childrearing Practices KW - Fathers KW - Adolescents KW - Sociodemographic Characteristics KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/764426343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Marriage+and+Family&rft.atitle=Single+Custodial+Fathers%27+Involvement+and+Parenting%3A+Implications+for+Outcomes+in+Emerging+Adulthood&rft.au=Bronte-Tinkew%2C+Jacinta%3BScott%2C+Mindy+E%3BLilja%2C+Emily&rft.aulast=Bronte-Tinkew&rft.aufirst=Jacinta&rft.date=2010-10-01&rft.volume=72&rft.issue=5&rft.spage=1107&rft.isbn=&rft.btitle=&rft.title=Journal+of+Marriage+and+Family&rft.issn=00222445&rft_id=info:doi/10.1111%2Fj.1741-3737.2010.00753.x LA - English DB - Sociological Abstracts N1 - Date revised - 2010-11-11 N1 - Number of references - 62 N1 - Last updated - 2016-09-28 N1 - CODEN - JMFAA6 N1 - SubjectsTermNotLitGenreText - Family; Childrearing Practices; Sociodemographic Characteristics; Life Stage Transitions; Adolescents; Fathers DO - http://dx.doi.org/10.1111/j.1741-3737.2010.00753.x ER - TY - JOUR T1 - Bifunctional fusion proteins of the human engineered antibody domain m36 with human soluble CD4 are potent inhibitors of diverse HIV-1 isolates AN - 762270284; 13809075 AB - Currently used antiretroviral therapy is highly successful but there is still a need for new effective and safe prophylactics and therapeutics. We have previously identified and characterized a human engineered antibody domain (eAd), m36, which exhibits potent broadly neutralizing activity against HIV-1 by targeting a highly conserved CD4 binding-induced (CD4i) structure on the viral envelope glycoprotein (Env) gp120. m36 has very small size (a1415kDa) but is highly specific and is likely to be safe in long-term use thus representing a novel class of potentially promising HIV-1 inhibitors. Major problems with the development of m36 as a candidate therapeutic are possible short serum half life and lack of effector functions that could be important for effective protection in vivo. Fusion of m36 to human IgG1 Fc resulted in dramatically diminished neutralization potency most likely due to the sterically restricted nature of the m36 epitope that limits access of large molecules. To confer effector functions and simultaneously increase the potency, we first matured m36 by panning and screening a mutant library for mutants with increased binding to gp120. We next fused m36 and its mutants with the first two domains (soluble CD4, sCD4) of the human CD4 using a polypeptide linker. Our results showed that the selected m36 mutants and the sCD4 fusion proteins exhibited more potent antiviral activities than m36. The m36-sCD4 fusion proteins with human IgG1 Fc showed even higher potency likely due to their bivalency and increased avidity although with a greater increase in molecular size. Our data suggest that m36 derivatives are promising HIV-1 candidate therapeutics and tools to study highly conserved gp120 structures with implications for understanding mechanisms of entry and design of vaccine immunogens and small-molecule inhibitors. JF - Antiviral Research AU - Chen, Weizao AU - Xiao, Xiaodong AU - Wang, Yanping AU - Zhu, Zhongyu AU - Dimitrov, Dimiter S AD - Protein Interactions Group, Center for Cancer Research Nanobiology Program, National Cancer Institute (NCI)-Frederick, National Institutes of Health (NIH), Frederick, MD 21702-1201, USA, chenw3@mail.nih.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 107 EP - 115 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 88 IS - 1 SN - 0166-3542, 0166-3542 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Antibodies KW - CD4 antigen KW - Human immunodeficiency virus 1 KW - V:22360 KW - A:01340 KW - F:06910 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762270284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=Bifunctional+fusion+proteins+of+the+human+engineered+antibody+domain+m36+with+human+soluble+CD4+are+potent+inhibitors+of+diverse+HIV-1+isolates&rft.au=Chen%2C+Weizao%3BXiao%2C+Xiaodong%3BWang%2C+Yanping%3BZhu%2C+Zhongyu%3BDimitrov%2C+Dimiter+S&rft.aulast=Chen&rft.aufirst=Weizao&rft.date=2010-10-01&rft.volume=88&rft.issue=1&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2010.08.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - CD4 antigen; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.antiviral.2010.08.004 ER - TY - JOUR T1 - Serum estrogen and tumor-positive estrogen receptor-alpha are strong prognostic classifiers of non-small-cell lung cancer survival in both men and women. AN - 757178421; 20729390 AB - The role of tumor estrogen receptors (ERs) and serum estrogen in lung cancer is inconclusive. We investigated the hypothesis that ERs and functional single-nucleotide polymorphisms in the estrogen biosynthesis pathway are associated with poorer lung cancer survival. Lung cancer patients (n = 305) from a National Cancer Institute-Maryland (NCI-MD) case-case cohort in the Baltimore metropolitan area were used as a test cohort. To validate, 227 cases from the NCI-MD case-control cohort and 293 cases from a Norwegian lung cancer cohort were studied. Information on demographics, tobacco and reproductive histories was collected in an interviewer-administered questionnaire. Serum estrogen, progesterone, tumor messenger RNA expression of hormone receptors and germ line DNA polymorphisms were analyzed for associations with lung cancer survival. Patients in the highest tertile of serum estrogen had worse survival in all three cohorts (P combined < 0.001). Furthermore, the variant allele of estrogen receptor alpha (ER-α) polymorphism (rs2228480) was significantly associated with increased tumor ER-α levels and worse survival in all three cohorts [hazard ratio (HR) = 2.59, 95% confidence interval (CI): 1.20- 4.01; HR = 1.76, 95% CI: 1.08-2.87 and HR = 2.85, 95% CI: 1.31-4.36). Other polymorphisms associated with lower serum estrogen correlated with improved survival. Results were independent of gender and hormone replacement therapy. We report a significant association of increased serum estrogen with poorer survival among lung cancer male and female patients. Understanding the genetic control of estrogen biosynthesis and response in lung cancer could lead to improved prognosis and therapy. JF - Carcinogenesis AU - Olivo-Marston, Susan E AU - Mechanic, Leah E AU - Mollerup, Steen AU - Bowman, Elise D AU - Remaley, Alan T AU - Forman, Michele R AU - Skaug, Vidar AU - Zheng, Yun-Ling AU - Haugen, Aage AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 1778 EP - 1786 VL - 31 IS - 10 KW - Estrogen Receptor alpha KW - 0 KW - Estrogens KW - RNA, Messenger KW - estrogen receptor alpha, human KW - Progesterone KW - 4G7DS2Q64Y KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Index Medicus KW - Cytochrome P-450 CYP1A1 -- genetics KW - Polymorphism, Single Nucleotide KW - Humans KW - RNA, Messenger -- analysis KW - Prognosis KW - Aged KW - Aged, 80 and over KW - Adult KW - Cohort Studies KW - Case-Control Studies KW - Middle Aged KW - Progesterone -- blood KW - Female KW - Male KW - Carcinoma, Non-Small-Cell Lung -- blood KW - Estrogen Receptor alpha -- genetics KW - Carcinoma, Non-Small-Cell Lung -- mortality KW - Lung Neoplasms -- blood KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - Estrogen Receptor alpha -- analysis KW - Lung Neoplasms -- genetics KW - Lung Neoplasms -- mortality KW - Estrogens -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/757178421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Serum+estrogen+and+tumor-positive+estrogen+receptor-alpha+are+strong+prognostic+classifiers+of+non-small-cell+lung+cancer+survival+in+both+men+and+women.&rft.au=Olivo-Marston%2C+Susan+E%3BMechanic%2C+Leah+E%3BMollerup%2C+Steen%3BBowman%2C+Elise+D%3BRemaley%2C+Alan+T%3BForman%2C+Michele+R%3BSkaug%2C+Vidar%3BZheng%2C+Yun-Ling%3BHaugen%2C+Aage%3BHarris%2C+Curtis+C&rft.aulast=Olivo-Marston&rft.aufirst=Susan&rft.date=2010-10-01&rft.volume=31&rft.issue=10&rft.spage=1778&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgq156 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-10 N1 - Date created - 2010-10-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst Monogr. 2000;(27):95-112 [10963622] Br Med Bull. 1996 Jan;52(1):58-73 [8746297] Breast Cancer Res. 2000;2(5):360-6 [11250729] Int J Cancer. 2002 Jan 20;97(3):365-71 [11774290] Mol Cell Endocrinol. 2002 Feb 25;188(1-2):125-40 [11911952] Cancer Res. 2002 Apr 1;62(7):2141-50 [11929836] Ann Thorac Cardiovasc Surg. 2002 Apr;8(2):69-73 [12027790] Biochem Cell Biol. 2002;80(3):335-41 [12123286] Lung Cancer. 2002 Aug;37(2):153-9 [12140138] BMC Cancer. 2002 Dec 26;2:36 [12502433] Carcinogenesis. 2003 Feb;24(2):269-74 [12584177] J Epidemiol. 2003 Jan;13(1):22-8 [12587610] Biomed Pharmacother. 2003 Dec;57(10):460-2 [14637389] Steroids. 1997 Jan;62(1):164-8 [9029732] Endocr Rev. 1997 Aug;18(4):502-19 [9267762] J Clin Oncol. 1998 Feb;16(2):651-7 [9469354] Chest. 1999 Jan;115(1):233-5 [9925089] Mol Endocrinol. 1999 Feb;13(2):286-96 [9973258] Carcinogenesis. 2005 Mar;26(3):597-604 [15564288] Steroids. 2005 May-Jun;70(5-7):372-81 [15862820] Clin Cancer Res. 2005 Jul 15;11(14):5084-9 [16033821] Clin Cancer Res. 2005 Oct 15;11(20):7280-7 [16243798] Cancer Res. 2005 Dec 15;65(24):11287-91 [16357134] J Clin Oncol. 2006 Jan 1;24(1):59-63 [16314616] Contraception. 2006 Apr;73(4):331-5 [16531161] PLoS Med. 2006 Nov;3(11):e442 [17132052] Am J Epidemiol. 2007 Feb 1;165(3):235-45 [17110639] Int J Cancer. 2007 May 15;120(10):2214-20 [17278095] Nat Genet. 2007 May;39(5):655-60 [17417639] Cancer Res. 2007 Nov 1;67(21):10484-90 [17974992] J Clin Oncol. 2007 Dec 20;25(36):5785-92 [18089876] Adv Exp Med Biol. 2008;617:377-84 [18497061] Nat Genet. 2008 Jul;40(7):806-7; author reply 810-2 [18583964] Nat Genet. 2008 Jul;40(7):807-8; author reply 810-2 [18583965] Hum Pathol. 2008 Oct;39(10):1465-73 [18620727] Ann N Y Acad Sci. 2009 Feb;1155:194-205 [19250205] Mol Cell Endocrinol. 2009 Jun 16;305(1-2):12-21 [19433257] Lancet. 2009 Oct 10;374(9697):1243-51 [19767090] J Clin Oncol. 2010 Mar 20;28(9):1540-6 [20159813] Ann Thorac Surg. 2003 Dec;76(6):1789-95 [14667585] Crit Rev Oncol Hematol. 2004 Apr;50(1):3-22 [15094156] J Natl Cancer Inst. 2004 Jun 16;96(12):936-45 [15199113] J Surg Oncol. 1984 Apr;25(4):255-62 [6371384] Cancer Res. 1988 Dec 15;48(24 Pt 1):7279-84 [3191498] Int J Cancer. 1989 Nov 15;44(5):833-9 [2583865] J Natl Cancer Inst. 1994 Jun 1;86(11):869-70 [8182770] J Thorac Cardiovasc Surg. 1994 Jul;108(1):153-7 [8028359] Mol Endocrinol. 1995 Jul;9(7):814-25 [7476965] Lung Cancer. 1996 Mar;14 Suppl 1:S215-21 [8785664] Arch Pathol Lab Med. 2000 Oct;124(10):1467-70 [11035577] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgq156 ER - TY - JOUR T1 - Activation of the latent PlcR regulon in Bacillus anthracis. AN - 756660494; 20688829 AB - Many genes in Bacillus cereus and Bacillus thuringiensis are under the control of the transcriptional regulator PlcR and its regulatory peptide, PapR. In Bacillus anthracis, the causative agent of anthrax, PlcR is inactivated by truncation, and consequently genes having PlcR binding sites are expressed at very low levels when compared with B. cereus. We found that activation of the PlcR regulon in B. anthracis by expression of a PlcR-PapR fusion protein does not alter sporulation in strains containing the virulence plasmid pXO1 and thereby the global regulator AtxA. Using comparative 2D gel electrophoresis, we showed that activation of the PlcR regulon in B. anthracis leads to upregulation of many proteins found in the secretome of B. cereus, including phospholipases and proteases, such as the putative protease BA1995. Transcriptional analysis demonstrated expression of BA1995 to be dependent on PlcR-PapR, even though the putative PlcR recognition site of the BA1995 gene does not exactly match the PlcR consensus sequence, explaining why this protein had escaped recognition as belonging to the PlcR regulon. Additionally, while transcription of major PlcR-dependent haemolysins, sphingomyelinase and anthrolysin O is enhanced in response to PlcR activation in B. anthracis, only anthrolysin O contributes significantly to lysis of human erythrocytes. In contrast, the toxicity of bacterial culture supernatants from a PlcR-positive strain towards murine macrophages occurred independently of anthrolysin O expression in vitro and in vivo. JF - Microbiology (Reading, England) AU - Sastalla, Inka AU - Maltese, Lauren M AU - Pomerantseva, Olga M AU - Pomerantsev, Andrei P AU - Keane-Myers, Andrea AU - Leppla, Stephen H AD - Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 2982 EP - 2993 VL - 156 KW - ATXA protein, Bacillus anthracis KW - 0 KW - Bacterial Proteins KW - PlcR protein, Bacillus KW - Recombinant Fusion Proteins KW - Trans-Activators KW - Index Medicus KW - Gene Expression Regulation, Bacterial KW - Animals KW - Macrophages -- microbiology KW - Humans KW - Amino Acid Sequence KW - Mice KW - Plasmids KW - Mice, Inbred DBA KW - Mutagenesis KW - Virulence KW - Recombinant Fusion Proteins -- metabolism KW - Molecular Sequence Data KW - Bacillus cereus -- genetics KW - Bacillus cereus -- metabolism KW - Anthrax -- microbiology KW - Trans-Activators -- metabolism KW - Bacterial Proteins -- genetics KW - Bacillus anthracis -- genetics KW - Trans-Activators -- genetics KW - Bacterial Proteins -- metabolism KW - Bacillus anthracis -- pathogenicity KW - Regulon UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756660494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology+%28Reading%2C+England%29&rft.atitle=Activation+of+the+latent+PlcR+regulon+in+Bacillus+anthracis.&rft.au=Sastalla%2C+Inka%3BMaltese%2C+Lauren+M%3BPomerantseva%2C+Olga+M%3BPomerantsev%2C+Andrei+P%3BKeane-Myers%2C+Andrea%3BLeppla%2C+Stephen+H&rft.aulast=Sastalla&rft.aufirst=Inka&rft.date=2010-10-01&rft.volume=156&rft.issue=&rft.spage=2982&rft.isbn=&rft.btitle=&rft.title=Microbiology+%28Reading%2C+England%29&rft.issn=1465-2080&rft_id=info:doi/10.1099%2Fmic.0.041418-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-22 N1 - Date created - 2010-10-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Bacteriol. 2009 Aug;191(16):5134-46 [19502400] Appl Environ Microbiol. 2009 Apr;75(7):2099-110 [19181829] Microbiology. 1999 Nov;145 ( Pt 11):3129-38 [10589720] Protein Expr Purif. 2000 Apr;18(3):293-302 [10733882] Appl Environ Microbiol. 2000 Jun;66(6):2627-30 [10831447] Microbiology. 2000 Dec;146 Pt 12:3033-9 [11101661] Annu Rev Microbiol. 2001;55:647-71 [11544370] Mol Microbiol. 2001 Dec;42(5):1189-98 [11886551] Proteomics. 2002 Jun;2(6):784-91 [12112862] Biochem Biophys Res Commun. 2003 Apr 11;303(3):855-62 [12670489] J Bacteriol. 2003 May;185(9):2820-5 [12700261] Nature. 2003 May 1;423(6935):81-6 [12721629] Nature. 2003 May 1;423(6935):87-91 [12721630] Infect Immun. 2003 Jun;71(6):3183-9 [12761097] Infect Immun. 2003 Nov;71(11):6591-606 [14573681] Am J Pathol. 2003 Nov;163(5):1735-41 [14578173] J Bacteriol. 2004 Jun;186(11):3531-8 [15150241] Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8449-54 [15155910] Microb Pathog. 2004 Sep;37(3):149-54 [15351038] Infect Immun. 2004 Oct;72(10):5814-23 [15385482] Arch Biochem Biophys. 1980 Feb;199(2):572-8 [6244783] Infect Immun. 1983 Jan;39(1):371-6 [6401695] Infect Immun. 1986 May;52(2):454-8 [3084383] J Bacteriol. 1987 Nov;169(11):5263-70 [3117773] Methods Enzymol. 1988;165:103-16 [3148094] Clin Microbiol Rev. 1993 Oct;6(4):324-38 [8269390] J Bacteriol. 1996 May;178(10):2749-56 [8631661] FEMS Microbiol Lett. 1996 Aug 1;141(2-3):151-6 [8768516] Infect Immun. 1997 Jul;65(7):2576-82 [9199422] Mol Microbiol. 1999 Jun;32(5):1043-53 [10361306] Protein Sci. 1999 Aug;8(8):1714-9 [10452618] J Bacteriol. 1956 Jan;71(1):25-42 [13286227] Bioinformatics. 2005 Mar 1;21(5):617-23 [15501914] FEMS Microbiol Rev. 2005 Apr;29(2):303-29 [15808746] Proteomics. 2005 Sep;5(14):3696-711 [16167365] Infect Immun. 2005 Oct;73(10):6199-209 [16177291] J Bacteriol. 2006 May;188(10):3551-71 [16672610] J Bacteriol. 2006 Aug;188(15):5333-44 [16855222] BMC Microbiol. 2006;6:56 [16790055] J Clin Microbiol. 2006 Sep;44(9):3352-60 [16954272] J Bacteriol. 2006 Nov;188(22):7823-9 [16980467] Nat Protoc. 2007;2(4):953-71 [17446895] Nucleic Acids Res. 2008 Jun;36(11):3791-801 [18492723] PLoS One. 2008;3(7):e2793 [18665214] PLoS One. 2009;4(3):e4904 [19295911] Annu Rev Microbiol. 2009;63:451-76 [19514852] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1099/mic.0.041418-0 ER - TY - JOUR T1 - "Click" reaction in conjunction with diazeniumdiolate chemistry: developing high-load nitric oxide donors. AN - 755178925; 20812718 AB - The use of Cu(I)-catalyzed "click" reactions of alkyne-substituted diazeniumdiolate prodrugs with bis- and tetrakis-azido compounds is described. The "click" reaction for the bis-azide using CuSO(4)/Na-ascorbate predominantly gave the expected bis-triazole. However, CuI/diisopropylethylamine predominantly gave uncommon triazolo-triazole products as a result of oxidative coupling. Neither set of "click" conditions showed evidence of compromising the integrity of the diazeniumdiolate groups. The chemistry developed has applications in the synthesis of polyvalent and dendritic nitric oxide donors. JF - Organic letters AU - Oladeinde, Oyebola A AU - Hong, Sam Y AU - Holland, Ryan J AU - Maciag, Anna E AU - Keefer, Larry K AU - Saavedra, Joseph E AU - Nandurdikar, Rahul S AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. Y1 - 2010/10/01/ PY - 2010 DA - 2010 Oct 01 SP - 4256 EP - 4259 VL - 12 IS - 19 KW - Azides KW - 0 KW - Azo Compounds KW - Nitric Oxide Donors KW - diazeniumdiolate KW - Index Medicus KW - Molecular Structure KW - Cyclization KW - Azides -- chemistry KW - Azo Compounds -- chemistry KW - Nitric Oxide Donors -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755178925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Organic+letters&rft.atitle=%22Click%22+reaction+in+conjunction+with+diazeniumdiolate+chemistry%3A+developing+high-load+nitric+oxide+donors.&rft.au=Oladeinde%2C+Oyebola+A%3BHong%2C+Sam+Y%3BHolland%2C+Ryan+J%3BMaciag%2C+Anna+E%3BKeefer%2C+Larry+K%3BSaavedra%2C+Joseph+E%3BNandurdikar%2C+Rahul+S&rft.aulast=Oladeinde&rft.aufirst=Oyebola&rft.date=2010-10-01&rft.volume=12&rft.issue=19&rft.spage=4256&rft.isbn=&rft.btitle=&rft.title=Organic+letters&rft.issn=1523-7052&rft_id=info:doi/10.1021%2Fol101645k LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-06 N1 - Date created - 2010-09-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Exp Ther. 2002 Jan;300(1):18-25 [11752092] Org Lett. 2010 Jan 1;12(1):56-9 [19954198] Chem Rev. 2002 Apr;102(4):1091-134 [11942788] Chem Rev. 2002 Apr;102(4):1135-54 [11942789] Expert Opin Investig Drugs. 2002 May;11(5):587-601 [11996642] Angew Chem Int Ed Engl. 2002 Jul 15;41(14):2596-9 [12203546] Drug Discov Today. 2003 Dec 15;8(24):1128-37 [14678739] Pharmacol Rev. 1991 Jun;43(2):109-42 [1852778] Angew Chem Int Ed Engl. 2005 Apr 8;44(15):2210-5 [15693051] Angew Chem Int Ed Engl. 2007;46(7):1018-25 [17211903] Br J Pharmacol. 2007 Jun;151(3):305-21 [17401442] Angew Chem Int Ed Engl. 2007;46(20):3649-51 [17410632] ChemMedChem. 2008 May;3(5):715-23 [18214878] J Med Chem. 2008 Jul 10;51(13):3961-70 [18533711] Chem Rev. 2008 Aug;108(8):2952-3015 [18698735] Bioorg Med Chem Lett. 2009 May 15;19(10):2760-2 [19364650] Anticancer Agents Med Chem. 2009 Sep;9(7):798-803 [19538173] Chem Res Toxicol. 2002 Mar;15(3):269-99 [11896674] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ol101645k ER - TY - JOUR T1 - Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. AN - 755177581; 20842054 AB - New, effective therapies are needed for pancreatic ductal adenocarcinoma. Ipilimumab can mediate an immunologic tumor regression in other histologies. This phase II trial evaluated the efficacy of Ipilimumab for advanced pancreatic cancer. Subjects were adults with locally advanced or metastatic pancreas adenocarcinoma with measurable disease, good performance status, and minimal comorbidities. Ipilimumab was administered intravenously (3.0 mg/kg every 3 wk; 4 doses/course) for a maximum of 2 courses. Response rate by response evaluation criteria in solid tumors criteria and toxicity were measured. Twenty-seven subjects were enrolled (metastatic disease: 20 and locally advanced: 7) with median age of 55 years (27 to 68 y) and good performance status (26 with Eastern Cooperative Oncology Group performance status =0 to 1). Three subjects experienced ≥ grade 3 immune-mediated adverse events (colitis:1, encephalitis:1, hypohysitis:1). There were no responders by response evaluation criteria in solid tumors criteria but a subject experienced a delayed response after initial progressive disease. In this subject, new metastases after 2 doses of Ipilimumab established progressive disease. But continued administration of the agent per protocol resulted in significant delayed regression of the primary lesion and 20 hepatic metastases. This was reflected in tumor markers normalization, and clinically significant improvement of performance status. Single agent Ipilimumab at 3.0 mg/kg/dose is ineffective for the treatment of advanced pancreas cancer. However, a significant delayed response in one subject of this trial suggests that immunotherapeutic approaches to pancreas cancer deserve further exploration. JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Royal, Richard E AU - Levy, Catherine AU - Turner, Keli AU - Mathur, Aarti AU - Hughes, Marybeth AU - Kammula, Udai S AU - Sherry, Richard M AU - Topalian, Suzanne L AU - Yang, James C AU - Lowy, Israel AU - Rosenberg, Steven A AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. rroyal@mdanderson.org Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 828 EP - 833 VL - 33 IS - 8 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD KW - CTLA-4 Antigen KW - CTLA4 protein, human KW - ipilimumab KW - 6T8C155666 KW - Index Medicus KW - Colitis -- etiology KW - Treatment Failure KW - Injections, Intravenous KW - Colitis -- immunology KW - Humans KW - Adult KW - Neoplasm Metastasis KW - Disease Progression KW - Aged KW - Middle Aged KW - Male KW - Female KW - Adenocarcinoma -- physiopathology KW - Pancreatic Neoplasms -- physiopathology KW - Pancreatic Neoplasms -- pathology KW - Pancreatic Neoplasms -- therapy KW - Immunotherapy KW - Antibodies, Monoclonal -- adverse effects KW - Adenocarcinoma -- therapy KW - Adenocarcinoma -- immunology KW - Pancreatic Neoplasms -- immunology KW - Antigens, CD -- immunology KW - Antibodies, Monoclonal -- administration & dosage KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755177581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=Phase+2+trial+of+single+agent+Ipilimumab+%28anti-CTLA-4%29+for+locally+advanced+or+metastatic+pancreatic+adenocarcinoma.&rft.au=Royal%2C+Richard+E%3BLevy%2C+Catherine%3BTurner%2C+Keli%3BMathur%2C+Aarti%3BHughes%2C+Marybeth%3BKammula%2C+Udai+S%3BSherry%2C+Richard+M%3BTopalian%2C+Suzanne+L%3BYang%2C+James+C%3BLowy%2C+Israel%3BRosenberg%2C+Steven+A&rft.aulast=Royal&rft.aufirst=Richard&rft.date=2010-10-01&rft.volume=33&rft.issue=8&rft.spage=828&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=1537-4513&rft_id=info:doi/10.1097%2FCJI.0b013e3181eec14c LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-17 N1 - Date created - 2010-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/CJI.0b013e3181eec14c ER - TY - JOUR T1 - Longitudinal changes in cortical thickness associated with normal aging AN - 754880998; 13401142 AB - Imaging studies of anatomic changes in regional gray matter volumes and cortical thickness have documented age effects in many brain regions, but the majority of such studies have been cross-sectional investigations of individuals studied at a single point in time. In this study, using serial imaging assessments of participants in the Baltimore Longitudinal Study of Aging (BLSA), we investigate longitudinal changes in cortical thickness during aging in a cohort of 66 older adults (mean age 68.78; sd. 6.6; range 60-84 at baseline) without dementia. We used the Cortical Reconstruction Using Implicit Surface Evolution CRUISE suite of algorithms to automatically generate a reconstruction of the cortical surface and identified twenty gyral based regions of interest per hemisphere. Using mixed effects regression, we investigated longitudinal changes in these regions over a mean follow-up interval of 8 years. The main finding in this study is that age-related decline in cortical thickness is widespread, but shows an anterior-posterior gradient with frontal and parietal regions, in general, exhibiting greater rates of decline than temporal and occipital. There were fewer regions in the right hemisphere showing statistically significant age-associated longitudinal decreases in mean cortical thickness. Males showed greater rates of decline in the middle frontal, inferior parietal, parahippocampal, postcentral, and superior temporal gyri in the left hemisphere, right precuneus and bilaterally in the superior parietal and cingulate regions. Significant nonlinear changes over time were observed in the postcentral, precentral, and orbitofrontal gyri on the left and inferior parietal, cingulate, and orbitofrontal gyri on the right. JF - NeuroImage AU - Thambisetty, Madhav AU - Wan, Jing AU - Carass, Aaron AU - An, Yang AU - Prince, Jerry L AU - Resnick, Susan M AD - Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD, USA, thambisettym@mail.nih.gov Y1 - 2010/10/01/ PY - 2010 DA - 2010 Oct 01 SP - 1215 EP - 1223 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 52 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Hemispheric laterality KW - Age KW - Aging KW - Brain KW - Algorithms KW - Statistical analysis KW - Cortex (parietal) KW - Dementia disorders KW - Geriatrics KW - Evolution KW - Substantia grisea KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754880998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Longitudinal+changes+in+cortical+thickness+associated+with+normal+aging&rft.au=Thambisetty%2C+Madhav%3BWan%2C+Jing%3BCarass%2C+Aaron%3BAn%2C+Yang%3BPrince%2C+Jerry+L%3BResnick%2C+Susan+M&rft.aulast=Thambisetty&rft.aufirst=Madhav&rft.date=2010-10-01&rft.volume=52&rft.issue=4&rft.spage=1215&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.04.258 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Cortex (parietal); Age; Hemispheric laterality; Neuroimaging; Dementia disorders; Aging; Geriatrics; Statistical analysis; Algorithms; Brain; Evolution; Substantia grisea DO - http://dx.doi.org/10.1016/j.neuroimage.2010.04.258 ER - TY - JOUR T1 - Automated brain tissue segmentation based on fractional signal mapping from inversion recovery Look-Locker acquisition AN - 754880668; 13401156 AB - Most current automated segmentation methods are performed on T sub(1)- or T sub(2)-weighted MR images, relying on relative image intensity that is dependent on other MR parameters and sensitive to B sub(1) magnetic field inhomogeneity. Here, we propose an image segmentation method based on quantitative longitudinal magnetization relaxation time (T sub(1)) of brain tissues. Considering the partial volume effect, fractional volume maps of brain tissues (white matter, gray matter, and cerebrospinal fluid) were obtained by fitting the observed signal in an inversion recovery procedure to a linear combination of three exponential functions, which represents the relaxations of each of the tissue types. A Look-Locker acquisition was employed to accelerate the acquisition process. The feasibility and efficacy of this proposed method were evaluated using simulations and experiments. The potential applications of this method in the study of neurological disease as well as normal brain development and aging are discussed. JF - NeuroImage AU - Shin, Wanyong AU - Geng, Xiujuan AU - Gu, Hong AU - Zhan, Wang AU - Zou, Qihong AU - Yang, Yihong AD - Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA, shinwa@nida.nih.govyihongyang@intra.nida.nih.gov Y1 - 2010/10/01/ PY - 2010 DA - 2010 Oct 01 SP - 1347 EP - 1354 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 52 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Magnetic resonance imaging KW - Automated segmentation KW - Brain tissue KW - Partial volume effect KW - Fractional volume KW - Fast T1 mapping KW - Brain mapping KW - Neuroimaging KW - Neurological diseases KW - Aging KW - Brain KW - Image processing KW - Substantia alba KW - Magnetic fields KW - Cerebrospinal fluid KW - Inversion KW - Segmentation KW - Substantia grisea KW - W 30910:Imaging KW - N3 11003:Developmental neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754880668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Automated+brain+tissue+segmentation+based+on+fractional+signal+mapping+from+inversion+recovery+Look-Locker+acquisition&rft.au=Shin%2C+Wanyong%3BGeng%2C+Xiujuan%3BGu%2C+Hong%3BZhan%2C+Wang%3BZou%2C+Qihong%3BYang%2C+Yihong&rft.aulast=Shin&rft.aufirst=Wanyong&rft.date=2010-10-01&rft.volume=52&rft.issue=4&rft.spage=1347&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Magnetic fields; Brain mapping; Cerebrospinal fluid; Neuroimaging; Neurological diseases; Inversion; Aging; Segmentation; Brain; Substantia alba; Image processing; Substantia grisea DO - http://dx.doi.org/10.1016/j.neuroimage.2010.05.001 ER - TY - JOUR T1 - The role of numeracy on client knowledge in BRCA genetic counseling AN - 754143102; 201026460 AB - Objective To assess the impact of numeracy and health literacy on client's ability to learn information orally communicated during a BRCA 1/2 genetic counseling session. Methods Fifty-nine videotaped simulated genetic counseling sessions were shown to 246 analogue clients (AC) recruited to imagine themselves as the client in the genetic counseling session. AC numeracy, genetic literacy, state and trait anxiety, and decisional conflict were assessed. The primary outcome was AC learning about BRCA 1/2. Results Health literacy and numeracy were moderately correlated, and each independently predicted learning. Higher numeracy was associated with higher knowledge scores only among ACs with adequate literacy. Decisional conflict was not related to literacy, numeracy, or knowledge acquisition. It was, however, inversely related to state anxiety so that the higher post-session state anxiety, the lower the AC's decisional conflict. Conclusion Numeracy and health literacy are associated with learning of orally communicated information during genetic counseling. It appears that numeracy can facilitate learning for literate subjects; it does not, however, make any difference in learning ability of clients with significant literacy deficits. Practice implications Numeracy plays an important role in client's ability to learn information communicated during medical sessions, especially among clients who are otherwise regarded as literate. [Copyright Elsevier B.V.] JF - Patient Education and Counseling AU - Portnoy, David B AU - Roter, Debra AU - Erby, Lori H AD - Cancer Prevention Fellowship Program, National Institutes of Health, Bethesda, MD, USA portnoydb@mail.nih.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 131 EP - 136 PB - Elsevier Ltd, The Netherlands VL - 81 IS - 1 SN - 0738-3991, 0738-3991 KW - Numeracy Patient-provider interaction Genetic counseling Patient learning KW - Ovarian cancer KW - Learning KW - Numeracy KW - Breast cancer KW - Literacy KW - Genetic counselling KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754143102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Patient+Education+and+Counseling&rft.atitle=The+role+of+numeracy+on+client+knowledge+in+BRCA+genetic+counseling&rft.au=Portnoy%2C+David+B%3BRoter%2C+Debra%3BErby%2C+Lori+H&rft.aulast=Portnoy&rft.aufirst=David&rft.date=2010-10-01&rft.volume=81&rft.issue=1&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Patient+Education+and+Counseling&rft.issn=07383991&rft_id=info:doi/10.1016%2Fj.pec.2009.09.036 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-09-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Numeracy; Learning; Genetic counselling; Literacy; Breast cancer; Ovarian cancer DO - http://dx.doi.org/10.1016/j.pec.2009.09.036 ER - TY - JOUR T1 - Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress. AN - 754031333; 20647536 AB - Macrophage activation and infiltration into resident tissues is known to mediate local inflammation and is a hallmark feature of metabolic syndrome. Members of the sirtuin family of proteins regulate numerous physiological processes, including those involved in nutrient regulation and the promotion of longevity. However, the important role that SIRT1, the leading sirtuin family member, plays in immune response remains unclear. In this study, we demonstrate that SIRT1 modulates the acetylation status of the RelA/p65 subunit of NF-κB and thus plays a pivotal role in regulating the inflammatory, immune, and apoptotic responses in mammals. Using a myeloid cell-specific SIRT1 knockout (Mac-SIRT1 KO) mouse model, we show that ablation of SIRT1 in macrophages renders NF-κB hyperacetylated, resulting in increased transcriptional activation of proinflammatory target genes. Consistent with increased proinflammatory gene expression, Mac-SIRT1 KO mice challenged with a high-fat diet display high levels of activated macrophages in liver and adipose tissue, predisposing the animals to development of systemic insulin resistance and metabolic derangement. In summary, we report that SIRT1, in macrophages, functions to inhibit NF-κB-mediated transcription, implying that myeloid cell-specific modulation of this sirtuin may be beneficial in the treatment of inflammation and its associated diseases. JF - Molecular and cellular biology AU - Schug, Thaddeus T AU - Xu, Qing AU - Gao, Huiming AU - Peres-da-Silva, Ashwin AU - Draper, David W AU - Fessler, Michael B AU - Purushotham, Aparna AU - Li, Xiaoling AD - Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. schugt@niehs.nih.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 4712 EP - 4721 VL - 30 IS - 19 KW - Cytokines KW - 0 KW - Dietary Fats KW - Transcription Factor RelA KW - Tumor Necrosis Factor-alpha KW - Histone Acetyltransferases KW - EC 2.3.1.48 KW - Sirt1 protein, mouse KW - EC 3.5.1.- KW - Sirtuin 1 KW - Index Medicus KW - Macrophages -- cytology KW - Animals KW - L Cells (Cell Line) KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Cytokines -- secretion KW - Dietary Fats -- administration & dosage KW - Mice KW - Glucose Intolerance -- metabolism KW - Macrophages -- drug effects KW - Mice, Knockout KW - Macrophage Activation -- drug effects KW - Acetylation KW - Blotting, Western KW - Myeloid Cells -- metabolism KW - Glucose Intolerance -- genetics KW - Cells, Cultured KW - Histone Acetyltransferases -- metabolism KW - Mice, Inbred C57BL KW - RNA Interference KW - Macrophages -- metabolism KW - Transcription Factor RelA -- metabolism KW - Transcription Factor RelA -- genetics KW - Sirtuin 1 -- genetics KW - Sirtuin 1 -- metabolism KW - Inflammation -- genetics KW - Inflammation -- metabolism KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754031333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Myeloid+deletion+of+SIRT1+induces+inflammatory+signaling+in+response+to+environmental+stress.&rft.au=Schug%2C+Thaddeus+T%3BXu%2C+Qing%3BGao%2C+Huiming%3BPeres-da-Silva%2C+Ashwin%3BDraper%2C+David+W%3BFessler%2C+Michael+B%3BPurushotham%2C+Aparna%3BLi%2C+Xiaoling&rft.aulast=Schug&rft.aufirst=Thaddeus&rft.date=2010-10-01&rft.volume=30&rft.issue=19&rft.spage=4712&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=1098-5549&rft_id=info:doi/10.1128%2FMCB.00657-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-15 N1 - Date created - 2010-09-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E419-28 [19996381] Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1047-53 [19299582] Nature. 2000 Feb 17;403(6771):795-800 [10693811] Free Radic Biol Med. 2000 Mar 1;28(5):683-92 [10754263] Proc Natl Acad Sci U S A. 2000 May 23;97(11):5807-11 [10811920] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6658-63 [10841563] Biochem Biophys Res Commun. 2000 Jul 5;273(2):793-8 [10873683] Science. 2001 Aug 31;293(5535):1653-7 [11533489] Cell. 2002 Apr;109 Suppl:S81-96 [11983155] Clin Microbiol Rev. 2002 Jul;15(3):414-29 [12097249] EMBO J. 2002 Dec 2;21(23):6539-48 [12456660] Nat Rev Immunol. 2003 Jan;3(1):23-35 [12511873] J Biol Chem. 2003 Jan 24;278(4):2758-66 [12419806] Nature. 2003 May 8;423(6936):181-5 [12736687] Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10794-9 [12960381] J Clin Invest. 2003 Dec;112(12):1796-808 [14679176] J Clin Invest. 2003 Dec;112(12):1821-30 [14679177] Cell. 2004 Feb 20;116(4):551-63 [14980222] EMBO J. 2004 Jun 16;23(12):2369-80 [15152190] Science. 2004 Jul 16;305(5682):390-2 [15205477] J Biol Chem. 1993 Dec 15;268(35):26055-8 [8253716] J Biol Chem. 1997 Jan 10;272(2):971-6 [8995390] Nature. 1997 Oct 9;389(6651):610-4 [9335502] Endocrinology. 1998 Dec;139(12):4832-8 [9832419] Physiol Behav. 2004 Dec 30;83(4):573-8 [15621062] J Bone Miner Res. 2006 Jul;21(7):993-1002 [16813520] J Clin Invest. 2006 Jul;116(7):1793-801 [16823477] J Biol Chem. 2006 Sep 8;281(36):26602-14 [16809344] Oncogene. 2006 Oct 30;25(51):6758-80 [17072327] J Clin Invest. 2006 Nov;116(11):3015-25 [17053832] J Clin Invest. 2006 Nov;116(11):2955-63 [17053836] Physiology (Bethesda). 2006 Dec;21:404-10 [17119153] Nature. 2006 Dec 14;444(7121):860-7 [17167474] Glia. 2007 Apr 1;55(5):453-62 [17203472] Trends Mol Med. 2007 Feb;13(2):64-71 [17207661] Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L567-76 [17041012] Nature. 2007 Jun 28;447(7148):1116-20 [17515919] J Immunol. 2008 Mar 1;180(5):3305-12 [18292555] Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9793-8 [18599449] Cell. 2008 Oct 3;135(1):61-73 [18854155] Cell. 2009 Jan 9;136(1):62-74 [19135889] Mol Cell Biol. 2009 Mar;29(5):1363-74 [19103747] Cell Metab. 2009 Apr;9(4):327-38 [19356714] J Immunol. 2000 Feb 15;164(4):2151-9 [10657669] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/MCB.00657-10 ER - TY - JOUR T1 - Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication. AN - 754023762; 20660205 AB - There is considerable HIV-1 variation in patients. The extent of the variation is due to the high rate of viral replication, the high viral load, and the errors made during viral replication. Mutations can arise from errors made either by host DNA-dependent RNA polymerase II or by HIV-1 reverse transcriptase (RT), but the relative contributions of these two enzymes to the mutation rate are unknown. In addition, mutations in RT can affect its fidelity, but the effect of mutations in RT on the nature of the mutations that arise in vivo is poorly understood. We have developed an efficient system, based on existing technology, to analyze the mutations that arise in an HIV-1 vector in a single cycle of replication. A lacZalpha reporter gene is used to identify viral DNAs that contain mutations which are analyzed by DNA sequencing. The forward mutation rate in this system is 1.4 x 10(-5) mutations/bp/cycle, equivalent to the retroviral average. This rate is about 3-fold lower than previously reported for HIV-1 in vivo and is much lower than what has been reported for purified HIV-1 RT in vitro. Although the mutation rate was not affected by the orientation of lacZalpha, the sites favored for mutations (hot spots) in lacZalpha depended on which strand of lacZalpha was present in the viral RNA. The pattern of hot spots seen in lacZalpha in vivo did not match any of the published data obtained when purified RT was used to copy lacZalpha in vitro. JF - Journal of virology AU - Abram, Michael E AU - Ferris, Andrea L AU - Shao, Wei AU - Alvord, W Gregory AU - Hughes, Stephen H AD - HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA. Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 9864 EP - 9878 VL - 84 IS - 19 KW - DNA, Viral KW - 0 KW - reverse transcriptase, Human immunodeficiency virus 1 KW - EC 2.7.7.- KW - HIV Reverse Transcriptase KW - EC 2.7.7.49 KW - Index Medicus KW - Plasmids -- genetics KW - Humans KW - INDEL Mutation KW - Frameshift Mutation KW - HIV Reverse Transcriptase -- genetics KW - Base Sequence KW - Genetic Vectors KW - Point Mutation KW - Genes, Reporter KW - Molecular Sequence Data KW - Genes, Viral KW - DNA, Viral -- genetics KW - Lac Operon KW - Mutagenesis, Insertional KW - Cell Line KW - Sequence Deletion KW - HIV-1 -- genetics KW - Virus Replication -- genetics KW - HIV-1 -- physiology KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754023762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Nature%2C+position%2C+and+frequency+of+mutations+made+in+a+single+cycle+of+HIV-1+replication.&rft.au=Abram%2C+Michael+E%3BFerris%2C+Andrea+L%3BShao%2C+Wei%3BAlvord%2C+W+Gregory%3BHughes%2C+Stephen+H&rft.aulast=Abram&rft.aufirst=Michael&rft.date=2010-10-01&rft.volume=84&rft.issue=19&rft.spage=9864&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.00915-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-28 N1 - Date created - 2010-09-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 1998 Jun;72(6):5198-206 [9573292] J Virol. 1998 Nov;72(11):8463-71 [9765382] Eur J Biochem. 1998 Dec 15;258(3):1032-9 [9990322] J Virol. 2005 Sep;79(18):12045-57 [16140780] MedGenMed. 2005;7(1):69 [16369374] DNA Repair (Amst). 2006 Nov 8;5(11):1346-63 [16884961] J Virol. 2007 Jan;81(2):917-23 [17079286] J Biol Chem. 1999 Nov 12;274(46):32924-30 [10551858] J Virol. 1999 Dec;73(12):10489-502 [10559367] J Virol. 2000 Feb;74(3):1234-40 [10627533] J Virol. 2000 Jul;74(14):6494-500 [10864662] J Biol Chem. 2000 Sep 1;275(35):27037-44 [10833521] Annu Rev Biochem. 2000;69:497-529 [10966467] J Virol. 2000 Oct;74(20):9532-9 [11000223] Curr HIV Res. 2007 Jan;5(1):23-45 [17266555] J Med Invest. 2007 Feb;54(1-2):154-8 [17380027] Virology. 2007 Oct 25;367(2):253-64 [17631930] J Virol. 2008 Jan;82(2):719-27 [17989171] PLoS Pathog. 2009 Apr;5(4):e1000367 [19343218] J Virol. 2009 Oct;83(19):10119-28 [19605474] Nucleic Acids Res. 2009 Sep;37(17):5848-58 [19651874] EMBO J. 2001 Aug 1;20(15):4243-52 [11483527] Cell. 2001 Aug 24;106(4):465-75 [11525732] Eur J Biochem. 2002 Feb;269(3):859-67 [11846787] Genomics. 2002 Mar;79(3):285-96 [11863358] J Gen Virol. 2002 Apr;83(Pt 4):801-5 [11907329] Annu Rev Biochem. 2002;71:817-46 [12045112] J Virol. 2002 Sep;76(18):9253-9 [12186909] J Biol Chem. 2002 Oct 11;277(41):38053-61 [12151398] J Virol. 2002 Nov;76(22):11273-82 [12388687] Front Biosci. 2003 Jan 1;8:d117-34 [12456349] J Biol Chem. 2003 Jan 17;278(3):1391-4 [12446659] J Virol. 2003 Feb;77(3):2071-80 [12525642] Science. 2003 May 16;300(5622):1112 [12750511] Cell. 2003 Jun 13;113(6):803-9 [12809610] Nucleic Acids Res. 2003 Jul 1;31(13):3406-15 [12824337] Nature. 2003 Jul 3;424(6944):99-103 [12808466] J Virol. 2003 Nov;77(22):12105-12 [14581547] Int J Biochem Cell Biol. 2004 Sep;36(9):1716-34 [15183340] AIDS. 2004 Jul 23;18(11):1503-11 [15238768] Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10380-5 [15240889] Proc Natl Acad Sci U S A. 1975 Apr;72(4):1254-7 [1093175] Proc Natl Acad Sci U S A. 1985 Jan;82(2):479-82 [3918310] J Biol Chem. 1986 Jan 5;261(1):160-6 [3941068] Cell. 1986 Jul 4;46(1):1-4 [3013415] Science. 1988 Nov 25;242(4882):1168-71 [2460924] Science. 1988 Nov 25;242(4882):1171-3 [2460925] Mol Cell Biol. 1989 Feb;9(2):469-76 [2469002] J Biol Chem. 1989 Oct 5;264(28):16948-56 [2476448] Genome. 1989;31(1):100-3 [2687085] Proc Natl Acad Sci U S A. 1990 Aug;87(16):6019-23 [2201018] Proc Natl Acad Sci U S A. 1990 Aug;87(16):6024-8 [2166940] Nature. 1990 Oct 11;347(6293):522 [2215679] Biochemistry. 1990 Sep 4;29(35):8003-11 [1702019] J Virol. 1991 Apr;65(4):1779-88 [2002543] Science. 1991 Nov 15;254(5034):963-9 [1683006] Biochemistry. 1992 Feb 4;31(4):954-8 [1370910] J Virol. 1992 May;66(5):3093-100 [1373201] Eur J Biochem. 1992 May 15;206(1):49-58 [1587282] Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6919-23 [1379727] J Biol Chem. 1993 May 15;268(14):10324-34 [7683675] Biochemistry. 1993 Jul 27;32(29):7559-67 [7687876] J Virol. 1994 Jan;68(1):494-9 [8254760] Virology. 1994 Mar;199(2):323-30 [7510083] J Virol. 1994 Jul;68(7):4196-203 [7515970] J Virol. 1994 Aug;68(8):4759-67 [8035477] Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9490-4 [7524077] Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11787-91 [7527543] Nature. 1995 Jan 12;373(6510):123-6 [7816094] Science. 1995 Jan 27;267(5197):483-9 [7824947] Curr Opin Genet Dev. 1994 Dec;4(6):895-900 [7888761] Nature. 1995 Jul 13;376(6536):125 [7603560] J Virol. 1995 Aug;69(8):5087-94 [7541846] J Virol. 1995 Sep;69(9):5878-82 [7543593] J Virol. 1995 Dec;69(12):7991-8000 [7494312] J Virol. 1996 Nov;70(11):7594-602 [8892879] AIDS Res Hum Retroviruses. 1996 Mar 1;12(4):307-14 [8906991] Arch Virol. 1997;142(6):1139-54 [9229004] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.00915-10 ER - TY - JOUR T1 - Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics. AN - 748987468; 20541539 AB - Ifosfamide (IF) and cyclophosphamide (CP) are common chemotherapeutic agents. Interestingly, while the two drugs are isomers, only IF treatment is known to cause nephrotoxicity and neurotoxicity. Therefore, it was anticipated that a comparison of IF and CP drug metabolites in the mouse would reveal reasons for this selective toxicity. Drug metabolites were profiled by ultra-performance liquid chromatography-linked electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOFMS), and the results analyzed by multivariate data analysis. Of the total 23 drug metabolites identified by UPLC-ESI-QTOFMS for both IF and CP, five were found to be novel. Ifosfamide preferentially underwent N-dechloroethylation, the pathway yielding 2-chloroacetaldehyde, while cyclophosphamide preferentially underwent ring-opening, the pathway yielding acrolein (AC). Additionally, S-carboxymethylcysteine and thiodiglycolic acid, two downstream IF and CP metabolites, were produced similarly in both IF- and CP-treated mice. This may suggest that other metabolites, perhaps precursors of thiodiglycolic acid, may be responsible for IF encephalopathy and nephropathy. Copyright (c) 2010 Elsevier Inc. All rights reserved. JF - Biochemical pharmacology AU - Li, Fei AU - Patterson, Andrew D AU - Höfer, Constance C AU - Krausz, Kristopher W AU - Gonzalez, Frank J AU - Idle, Jeffrey R AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, United States. lif3@mail.nih.gov Y1 - 2010/10/01/ PY - 2010 DA - 2010 Oct 01 SP - 1063 EP - 1074 VL - 80 IS - 7 KW - Pharmaceutical Preparations KW - 0 KW - Carbocysteine KW - 740J2QX53R KW - Cyclophosphamide KW - 8N3DW7272P KW - chloroacetaldehyde KW - CF069F5D9C KW - Acetaldehyde KW - GO1N1ZPR3B KW - Ifosfamide KW - UM20QQM95Y KW - Index Medicus KW - Acetaldehyde -- analogs & derivatives KW - Animals KW - Mice, Inbred C57BL KW - Chromatography, Liquid KW - Mass Spectrometry -- methods KW - Mice KW - Male KW - Metabolomics -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748987468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Comparative+metabolism+of+cyclophosphamide+and+ifosfamide+in+the+mouse+using+UPLC-ESI-QTOFMS-based+metabolomics.&rft.au=Li%2C+Fei%3BPatterson%2C+Andrew+D%3BH%C3%B6fer%2C+Constance+C%3BKrausz%2C+Kristopher+W%3BGonzalez%2C+Frank+J%3BIdle%2C+Jeffrey+R&rft.aulast=Li&rft.aufirst=Fei&rft.date=2010-10-01&rft.volume=80&rft.issue=7&rft.spage=1063&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=1873-2968&rft_id=info:doi/10.1016%2Fj.bcp.2010.06.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-27 N1 - Date created - 2010-08-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Chem Res Toxicol. 2010 May 17;23(5):851-60 [20232918] Nat New Biol. 1971 Oct 20;233(42):250-2 [20486278] Biomed Mass Spectrom. 1975 Feb;2(1):46-52 [1131393] Biochem Pharmacol. 1975 Jun 15;24(11-12):1233-5 [1169947] Arzneimittelforschung. 1975 Sep;25(9):1331-6 [1242654] Klin Wochenschr. 1975 Nov 15;53(22):1075-6 [1226040] Cancer Treat Rep. 1976 Apr;60(4):327-35 [1277208] Cancer Treat Rep. 1976 Apr;60(4):415-22 [1277216] Cancer Treat Rep. 1976 Apr;60(4):437-43 [1277219] Cancer Res. 1978 Feb;38(2):408-15 [620410] Arzneimittelforschung. 1979;29(4):659-61 [114192] J Cancer Res Clin Oncol. 1981;100(3):311-20 [6792207] Drug Metab Dispos. 1998 Mar;26(3):193-6 [9492379] Drug Metab Dispos. 1998 May;26(5):418-28 [9571223] Drug Metab Dispos. 1998 Sep;26(9):883-90 [9733667] Clin Cancer Res. 1997 Sep;3(9):1507-18 [9815837] Drug Metab Dispos. 1999 Sep;27(9):1092-7 [10460812] Klin Wochenschr. 1952 Oct 1;30(37-38):882-4 [13001136] Drug Metab Rev. 2005;37(4):611-703 [16393888] Toxicol Lett. 2006 Mar 1;161(3):188-94 [16229978] Chem Res Toxicol. 2006 Jun;19(6):818-27 [16780361] J Pharmacol Exp Ther. 2006 Sep;318(3):1330-42 [16775196] Biochem Pharmacol. 2007 Feb 15;73(4):561-73 [17123469] Chem Res Toxicol. 2007 Mar;20(3):531-42 [17279779] Anal Chem. 2008 Jan 1;80(1):115-22 [18027910] J Biol Chem. 2008 Feb 22;283(8):4543-59 [18093979] Endocrinology. 2008 Apr;149(4):1869-79 [18187545] Drug Metab Dispos. 1982 Nov-Dec;10(6):636-40 [6130913] Cancer Treat Rev. 1983 Sep;10 Suppl A:17-24 [6627242] Xenobiotica. 1983 Jul;13(7):433-7 [6659546] Biomed Environ Mass Spectrom. 1986 Mar;13(3):145-54 [2938656] Lancet. 1986 Nov 22;2(8517):1219-20 [2877353] Cancer Res. 1988 Sep 15;48(18):5167-71 [3409242] J Chromatogr. 1988 May 13;427(1):121-30 [3410892] J Pharmacol Exp Ther. 1992 Mar;260(3):1133-44 [1545382] J Chromatogr. 1992 Mar 13;575(1):137-42 [1517290] Toxicology. 1992 Nov 15;75(3):257-72 [1455433] Cancer Res. 1993 Aug 15;53(16):3758-64 [8339288] Cancer Res. 1994 Dec 1;54(23):6215-20 [7954469] Cancer Res. 1995 Feb 15;55(4):803-9 [7850793] Eur J Cancer. 1995;31A(1):69-76 [7695982] Cancer Chemother Pharmacol. 1995;36(1):53-60 [7720176] Drug Metab Dispos. 1995 Mar;23(3):433-7 [7628312] Eur J Cancer. 1995;31A(5):785-90 [7640054] Chem Res Toxicol. 1995 Oct-Nov;8(7):979-86 [8555414] Toxicol Appl Pharmacol. 1996 Jan;136(1):155-60 [8560469] Cancer Chemother Pharmacol. 1996;38(2):147-54 [8616905] J Chromatogr B Biomed Appl. 1995 Dec 15;674(2):205-17 [8788150] Eur J Clin Pharmacol. 1996;50(4):249-52 [8803513] Drug Metab Dispos. 1996 Dec;24(12):1336-9 [8971139] J Appl Toxicol. 1997 Jan-Feb;17(1):75-9 [9048231] Cell Mol Biol (Noisy-le-grand). 1997 Jul;43(5):773-82 [9298599] Life Sci. 2000 Nov 24;68(1):109-17 [11132240] J Am Soc Nephrol. 2001 Aug;12(8):1615-23 [11461933] J Pharmacol Exp Ther. 2001 Dec;299(3):1161-8 [11714908] Cancer. 1967 May;20(5):900-4 [6024299] Arzneimittelforschung. 1967 May;17(5):599-602 [5631588] Laval Med. 1968 Oct;39(8):696-701 [5748235] Mol Pharmacol. 1971 Sep;7(5):519-29 [5139563] Cancer Res. 1972 Apr;32(4):658-65 [5014778] Cancer Res. 1972 Nov;32(11):2519-23 [5082597] Cancer Res. 1973 Apr;33(4):651-8 [4696466] Cancer Res. 1973 Apr;33(4):915-8 [4696485] Biochem Pharmacol. 1974 Jan 1;23(1):115-29 [4811053] J Pharmacol Exp Ther. 2008 Nov;327(2):288-99 [18682571] J Mass Spectrom. 2009 Jul;44(7):999-1016 [19598168] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bcp.2010.06.002 ER - TY - JOUR T1 - Treatment of kitchen waste using a mobile thermophilic anaerobic digestion system AN - 744625815; 13139542 AB - A mobile thermophilic anaerobic digestion (TAnD, 55 degree C) system was developed to treat kitchen waste. A two-phase TAnD system was designed to fit in a 40 ft container (L x W x H = 1203 x 235 x 238 cm) with an initial designed capacity of 100 kg/d (assuming a solid content of 15%). During the grinding process, an equal amount of water was added to the kitchen waste (1:1 dilution) to maintain a manageable concentration and sludge flow conditions. The tested loading was up to 160 L/d. The system was operated at hydraulic retention times (HRT) of 5.6 and 25 days for hydrolysis and acidogenesis, respectively. The removal efficiencies of total COD (TCOD), suspended solids (SS), and volatile SS (VSS) were 72.5, 77.8, and 82.4%, respectively, with a specific gas production of 0.733 m super(3)/m super(3)d. JF - Renewable Energy AU - Kuo, Wen-Chien AU - Lai, Wen-Lung AD - Department of Environmental Science and Engineering, National Pingtung University of Science and Technology, 1 Hseuh Fu Rd., Nei Pu, Pingtung 91207, Taiwan, ROC, xwck@mail.npust.edu.tw Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 2335 EP - 2339 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 35 IS - 10 SN - 0960-1481, 0960-1481 KW - Sustainability Science Abstracts; Environment Abstracts KW - Containers KW - Suspended solids KW - Hydraulics KW - Chemical oxygen demand KW - Anaerobic digestion KW - Hydrolysis KW - Renewable energy KW - ENA 03:Energy KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744625815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Renewable+Energy&rft.atitle=Treatment+of+kitchen+waste+using+a+mobile+thermophilic+anaerobic+digestion+system&rft.au=Kuo%2C+Wen-Chien%3BLai%2C+Wen-Lung&rft.aulast=Kuo&rft.aufirst=Wen-Chien&rft.date=2010-10-01&rft.volume=35&rft.issue=10&rft.spage=2335&rft.isbn=&rft.btitle=&rft.title=Renewable+Energy&rft.issn=09601481&rft_id=info:doi/10.1016%2Fj.renene.2010.02.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Hydraulics; Suspended solids; Containers; Renewable energy; Chemical oxygen demand; Anaerobic digestion; Hydrolysis DO - http://dx.doi.org/10.1016/j.renene.2010.02.014 ER - TY - JOUR T1 - Sorption of trihalomethanes in foods. AN - 733984555; 20598747 AB - Trihalomethanes (THMs, namely, CHCl(3), CHCl(2)Br, CHClBr(2) and CHBr(3)) are disinfection by-products that are present in drinking water. These toxic chemicals are also present in meat, dairy products, vegetables, baked goods, beverages and other foods, although information regarding their concentrations and origin is very limited. This study investigates sorption of THMs occurring during rinsing and cooking of foods and the significance of food as an exposure source. Initial estimates of THM uptake were measured in experiments representing rinsing with tap water at 25 C using nine types of food, and for cooking in tap water at 90 C for fourteen other foods. A subset of foods was then selected for further study over a range of THM concentrations (23.7-118.7 microg/l), temperatures (25 C and 90 C), food concentrations (0.2-1.4, food weight: water weight), and contact times (5-240 min). Data were analyzed using regression and exponential models, and diffusion models were used to help explain the trends of THM uptake. Among vegetables, sorbed THM concentrations at 25 C were 213 to 774 ng/g for CHCl(3), 53 to 609 ng/g for CHCl(2)Br, and 150-845 ng/g for CHClBr(2). Meats at 90 C tended to have higher concentrations, e.g., 870-2634 ng/g for CHCl(3). Sorbed concentrations increased with contact time and THM concentration, and decreased with food concentration in rinsing tests (using spinach, iceberg-head lettuce and cauliflower) and cooking tests (using tomato, potato, beef and miso-tofu soup). For most foods, THM uptake was diffusion limited and several hours were needed to approach steady-state levels. Swelling, hydrolysis and other physical and chemical changes in the food can significantly affect sorption. Screening level estimates for CHCl(3) exposures, based on experimental results and typical food consumption patterns, show that uptake via foods can dominate that due to direct tap water consumption, suggesting the importance of sorption and the need for further evaluation of THM intake due to foods. Copyright 2010 Elsevier Ltd. All rights reserved. JF - Environment international AU - Huang, An-Tsun AU - Batterman, Stuart AD - Environmental Health Sciences, University of Michigan, 109 Observatory Drive, Ann Arbor, Michigan 48109-2029, USA. huangan@mail.nih.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 754 EP - 762 VL - 36 IS - 7 KW - Disinfectants KW - 0 KW - Environmental Pollutants KW - Trihalomethanes KW - Water KW - 059QF0KO0R KW - Index Medicus KW - Hydrophobic and Hydrophilic Interactions KW - Heating KW - Food Analysis KW - Water -- chemistry KW - Cooking KW - Adsorption KW - Absorption KW - Trihalomethanes -- chemistry KW - Food Contamination -- statistics & numerical data KW - Environmental Exposure -- analysis KW - Disinfectants -- chemistry KW - Environmental Pollutants -- chemistry KW - Environmental Pollutants -- analysis KW - Disinfectants -- analysis KW - Trihalomethanes -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733984555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Sorption+of+trihalomethanes+in+foods.&rft.au=Huang%2C+An-Tsun%3BBatterman%2C+Stuart&rft.aulast=Huang&rft.aufirst=An-Tsun&rft.date=2010-10-01&rft.volume=36&rft.issue=7&rft.spage=754&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2010.05.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-21 N1 - Date created - 2010-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.envint.2010.05.014 ER - TY - JOUR T1 - Production and antigenic properties of influenza virus from suspension MDCK-siat7e cells in a bench-scale bioreactor AN - 1500773113; 19273737 AB - In efforts to overcome limitations associated with egg-based influenza vaccines, mammalian cell substrates have gradually emerged as potential production platforms. Recently, a suspension Madin Darby canine kidney (MDCK) cell line for influenza virus production was created by expressing the human gene. To examine the broad susceptibility of this novel cell line, the scalability of the production process, and the antigenic stability of cell-derived progeny viruses, infection experiments using four current influenza vaccine strains (A/California/07/2009 X-179A H1N1, A/Brisbane/59/2007 IVR-148 H1N1, A/Uruguay/716/2007 X-175C H3N2, and B/Brisbane/60/2008) were performed. In small-scale experiments, this cell line was found to support high-titer replication of all four virus strains. Subsequently, production in a bench-scale bioreactor and the antigenic characteristics of progeny viruses were assessed. High titers of hemagglutinin (at least 1:512) were produced in a 2-L bench-scale bioreactor with all four strains. Immunoblot results demonstrated higher yields in the cells than those obtained in chicken embryonated eggs with three of the four tested strains. Progeny viruses collected after serial passages in this cell line exhibited minimal mutations in the HA-encoding gene. Hemagglutination inhibition (HAI) assays using ferret antiserum confirmed the antigenic stability. As a proof-of-concept this work demonstrates that by using a proper strategy, high yields of biologically active hemagglutinin can be produced from scalable cultures of suspension MDCK- cells. JF - Vaccine AU - Chu, Chia AU - Lugovtsev, Vladimir AU - Lewis, Andrew AU - Betenbaugh, Michael AU - Shiloach, Joseph AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, United States Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 7193 EP - 7201 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 28 IS - 44 SN - 0264-410X, 0264-410X KW - Biotechnology and Bioengineering Abstracts; Health & Safety Science Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Hemagglutination inhibition KW - Hemagglutinins KW - Viruses KW - Cell culture KW - Infection KW - Eggs KW - Influenza KW - Mammalian cells KW - Bioreactors KW - USA, California KW - Antigenic characteristics KW - Replication KW - Uruguay KW - Mustela putorius furo KW - Chickens KW - Influenza virus KW - Kidney KW - Progeny KW - Vaccines KW - Mutation KW - Australia, Queensland, Brisbane KW - F 06905:Vaccines KW - V 22300:Methods KW - W 30915:Pharmaceuticals & Vaccines KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1500773113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Production+and+antigenic+properties+of+influenza+virus+from+suspension+MDCK-siat7e+cells+in+a+bench-scale+bioreactor&rft.au=Chu%2C+Chia%3BLugovtsev%2C+Vladimir%3BLewis%2C+Andrew%3BBetenbaugh%2C+Michael%3BShiloach%2C+Joseph&rft.aulast=Chu&rft.aufirst=Chia&rft.date=2010-10-01&rft.volume=28&rft.issue=44&rft.spage=7193&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2010.08.059 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-01 N1 - Last updated - 2014-07-10 N1 - SubjectsTermNotLitGenreText - Antigenic characteristics; Replication; Hemagglutinins; Hemagglutination inhibition; Cell culture; Infection; Eggs; Influenza; Mammalian cells; Bioreactors; Progeny; Vaccines; Mutation; Chickens; Viruses; Kidney; Mustela putorius furo; Influenza virus; Uruguay; USA, California; Australia, Queensland, Brisbane DO - http://dx.doi.org/10.1016/j.vaccine.2010.08.059 ER - TY - JOUR T1 - Translating Research to Promote Healthy Aging: The Complementary Role of Longitudinal Studies and Clinical Trials AN - 1500764288; 19159269 AB - An important challenge in epidemiology is the difficulty in inferring causality from observational studies. Even the best longitudinal studies have limitations in this regard, and when clinical trials are feasible, they will provide more-definite evidence of causality, but even when clinical trials are feasible, a large amount can be learned about the disease process, assessment techniques, subject selection criteria, and the effect of potential interventions from longitudinal studies. This review covers the theoretical issues supporting the value and limitations of longitudinal studies, the practical utilization in clinical trials of different aspects of knowledge that can be gained from longitudinal studies, critical issues in the translation of longitudinal observational studies into clinical trials, and the value of observational studies in broadening the applicability of specific trials. Relevant issues are illustrated with examples of unsuccessful and successful trials, with a major emphasis on clinical trials of physical activity in older persons. JF - Journal of the American Geriatrics Society AU - Guralnik, Jack M AU - Kritchevsky, Stephen B AD - From the Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - S337 EP - S342 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 SN - 0002-8614, 0002-8614 KW - Health & Safety Science Abstracts KW - Longitudinal studies KW - Reviews KW - Physical activity KW - Aging KW - Intervention KW - Clinical trials KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1500764288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Translating+Research+to+Promote+Healthy+Aging%3A+The+Complementary+Role+of+Longitudinal+Studies+and+Clinical+Trials&rft.au=Guralnik%2C+Jack+M%3BKritchevsky%2C+Stephen+B&rft.aulast=Guralnik&rft.aufirst=Jack&rft.date=2010-10-01&rft.volume=58&rft.issue=&rft.spage=S337&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2010.02938.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-01 N1 - Document feature - figure 2 N1 - Last updated - 2014-06-12 N1 - SubjectsTermNotLitGenreText - Longitudinal studies; Physical activity; Reviews; Aging; Intervention; Clinical trials DO - http://dx.doi.org/10.1111/j.1532-5415.2010.02938.x ER - TY - JOUR T1 - Lifetime Prevalence of Mental Disorders in U.S. Adolescents: Results from the National Comorbidity Survey Replication-Adolescent Supplement (NCS-A) AN - 1221435237; 201229056 AB - Objective: To present estimates of the lifetime prevalence of DSM-IV mental disorders with and without severe impairment, their comorbidity across broad classes of disorder, and their sociodemographic correlates. Method: The National Comorbidity Survey-Adolescent Supplement NCS-A is a nationally representative face-to-face survey of 10,123 adolescents aged 13 to 18 years in the continental United States. DSM-IV mental disorders were assessed using a modified version of the fully structured World Health Organization Composite International Diagnostic Interview. Results: Anxiety disorders were the most common condition (31.9%), followed by behavior disorders (19.1%), mood disorders (14.3%), and substance use disorders (11.4%), with approximately 40% of participants with one class of disorder also meeting criteria for another class of lifetime disorder. The overall prevalence of disorders with severe impairment and/or distress was 22.2% (11.2% with mood disorders, 8.3% with anxiety disorders, and 9.6% behavior disorders). The median age of onset for disorder classes was earliest for anxiety (6 years), followed by 11 years for behavior, 13 years for mood, and 15 years for substance use disorders. Conclusions: These findings provide the first prevalence data on a broad range of mental disorders in a nationally representative sample of U.S. adolescents. Approximately one in every four to five youth in the U.S. meets criteria for a mental disorder with severe impairment across their lifetime. The likelihood that common mental disorders in adults first emerge in childhood and adolescence highlights the need for a transition from the common focus on treatment of U.S. youth to that of prevention and early intervention. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Merikangas, Kathleen Ries AU - He, Jian-ping AU - Burstein, Marcy AU - Swanson, Sonja A AU - Avenevoli, Shelli AU - Cui, Lihong AU - Benjet, Corina AU - Georgiades, Katholiki AU - Swendsen, Joel AD - National Institute of Mental Health, Genetic Epidemiology Research Branch, Building 35, Room 1A201, 35 Convent Drive, MSC #3720, Bethesda, MD 20892 kathleen.merikangas@nih.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 980 EP - 989 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 49 IS - 10 SN - 0890-8567, 0890-8567 KW - epidemiology, adolescents, mental disorders, National Comorbidity Survey, correlates KW - Affective disorders KW - Psychiatric disorders KW - Behaviour disorders KW - Comorbidity KW - Adolescents KW - Prevalence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1221435237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Lifetime+Prevalence+of+Mental+Disorders+in+U.S.+Adolescents%3A+Results+from+the+National+Comorbidity+Survey+Replication-Adolescent+Supplement+%28NCS-A%29&rft.au=Merikangas%2C+Kathleen+Ries%3BHe%2C+Jian-ping%3BBurstein%2C+Marcy%3BSwanson%2C+Sonja+A%3BAvenevoli%2C+Shelli%3BCui%2C+Lihong%3BBenjet%2C+Corina%3BGeorgiades%2C+Katholiki%3BSwendsen%2C+Joel&rft.aulast=Merikangas&rft.aufirst=Kathleen&rft.date=2010-10-01&rft.volume=49&rft.issue=10&rft.spage=980&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1016%2Fj.jaac.2010.05.017 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-12-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Psychiatric disorders; Prevalence; Adolescents; Comorbidity; Behaviour disorders; Affective disorders DO - http://dx.doi.org/10.1016/j.jaac.2010.05.017 ER - TY - JOUR T1 - Magnetic resonance lymphangiography with a nano-sized gadolinium-labeled dendrimer in small and large animal models AN - 1034824605; 17053374 AB - Aim: Imaging of the lymphatic system is critical in preoperative planning of resections of complex lymphatic malformations. However, safe, effective imaging methods with sufficient resolution to identify the lymphatics have been lacking. In this study, we demonstrate the use of gadolinium-labeled dendrimers to image the lymphatics in small and large animal models during magnetic resonance lymphangiography. Methods: Polyamidoamine G6-Gd_1B4M_N-hydroxysuccinimide was synthesized and administered intradermally in the extremities of normal mice and pigs at several doses. Results: The lymphatics were well demonstrated in both animal models and there was rapid uptake in the deep lymphatic system, including the thoracic duct. A significant dose reduction was achieved (1 mu mol Gd/kg) in the 35-kg pig compared with mice, while still producing excellent results. No toxicity was observed and only minor inflammatory changes were observed at the injection site 30 days later. Conclusion: We demonstrate that a low dose of a macromolecular magnetic resonance contrast agent can provide rapid imaging of the deep lymphatic system in both small and large animals. This data provides a basis to consider a similar agent in clinical trials. JF - Nanomedicine AU - Sena, Laureen M AU - Fishman, Steven J AU - Jenkins, Kathy J AU - Xu, Heng AU - Brechbiel, Martin W AU - Regino, Celeste AS AU - Kosaka, Nobuyuki AU - Bernardo, Marcelino AU - Choyke, Peter L AU - Kobayashi, Hisataka AD - super(1)Boston Children's Hospital, Boston, MA, USA, pchoyke@nih.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 1183 EP - 1191 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 5 IS - 8 SN - 1743-5889, 1743-5889 KW - Biotechnology and Bioengineering Abstracts KW - Animal models KW - Clinical trials KW - Contrast media KW - Data processing KW - Inflammation KW - Lymphangiography KW - Lymphatic system KW - Macromolecules KW - N.M.R. KW - Thoracic duct KW - Toxicity KW - imaging KW - nanotechnology KW - polyamidoamines KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034824605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanomedicine&rft.atitle=Magnetic+resonance+lymphangiography+with+a+nano-sized+gadolinium-labeled+dendrimer+in+small+and+large+animal+models&rft.au=Sena%2C+Laureen+M%3BFishman%2C+Steven+J%3BJenkins%2C+Kathy+J%3BXu%2C+Heng%3BBrechbiel%2C+Martin+W%3BRegino%2C+Celeste+AS%3BKosaka%2C+Nobuyuki%3BBernardo%2C+Marcelino%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Sena&rft.aufirst=Laureen&rft.date=2010-10-01&rft.volume=5&rft.issue=8&rft.spage=1183&rft.isbn=&rft.btitle=&rft.title=Nanomedicine&rft.issn=17435889&rft_id=info:doi/10.2217%2Fnnm.10.70 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Number of references - 24 N1 - Last updated - 2012-09-10 N1 - SubjectsTermNotLitGenreText - Macromolecules; Data processing; polyamidoamines; Animal models; Thoracic duct; Toxicity; imaging; Clinical trials; Lymphangiography; Inflammation; Contrast media; N.M.R.; Lymphatic system; nanotechnology DO - http://dx.doi.org/10.2217/nnm.10.70 ER - TY - JOUR T1 - Preferences for Genetic and Behavioral Health Information: The Impact of Risk Factors and Disease Attributions AN - 1032898970; 16467272 AB - Increased availability of genetic risk information may lead the public to give precedence to genetic causation over behavioral/environmental factors, decreasing motivation for behavior change. Few population-based data inform these concerns. We assess the association of family history, behavioral risks, and causal attributions for diseases and the perceived value of pursuing information emphasizing health habits or genes. 1,959 healthy adults completed a survey that assessed behavioral risk factors, family history, causal attributions of eight diseases, and health information preferences. Participants' causal beliefs favored health behaviors over genetics. Interest in behavioral information was higher than in genetic information. As behavioral risk factors increased, inclination toward genetic explanations increased; interest in how health habits affect disease risk decreased. Those at greatest need for behavior change may hold attributions that diminish interest in information for behavior change. Enhancing understanding of gene-environment influences could be explored to increase engagement with health information. JF - Annals of Behavioral Medicine AU - O'Neill, Suzanne C AU - McBride, Colleen M AU - Alford, Sharon Hensley AU - Kaphingst, Kimberly A AD - Social and Behavioral Research Branch, National Human Genome Research Institute/National Institutes of Health (NHGRI/NIH), Bethesda, MD, USA, sco4@georgetown.edu Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 127 EP - 137 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 40 IS - 2 SN - 0883-6612, 0883-6612 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Environmental factors KW - Genetics KW - Perception KW - Risk factors KW - R2 23060:Medical and environmental health KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1032898970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Behavioral+Medicine&rft.atitle=Preferences+for+Genetic+and+Behavioral+Health+Information%3A+The+Impact+of+Risk+Factors+and+Disease+Attributions&rft.au=O%27Neill%2C+Suzanne+C%3BMcBride%2C+Colleen+M%3BAlford%2C+Sharon+Hensley%3BKaphingst%2C+Kimberly+A&rft.aulast=O%27Neill&rft.aufirst=Suzanne&rft.date=2010-10-01&rft.volume=40&rft.issue=2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Annals+of+Behavioral+Medicine&rft.issn=08836612&rft_id=info:doi/10.1007%2Fs12160-010-9197-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Last updated - 2012-09-10 N1 - SubjectsTermNotLitGenreText - Genetics; Perception; Risk factors; Environmental factors DO - http://dx.doi.org/10.1007/s12160-010-9197-1 ER - TY - JOUR T1 - Clinical significance of early (< 20 weeks) vs. late (20-24 weeks) detection of sonographic short cervix in asymptomatic women in the mid-trimester AN - 1017976120; 16703973 AB - Objective The aim of this study was to determine whether the risk of early spontaneous preterm delivery (PTD) in asymptomatic women with a sonographic cervical length of 2 cm were excluded. The study population was stratified by gestational age at diagnosis (< 20 weeks vs. 20-24 weeks) and by cervical length (<= 10 mm vs. 11-15 mm). The primary outcome variables were PTD at < 28 and < 32 weeks of gestation and the diagnosis-to-delivery interval. Results The median gestational age at diagnosis of a short cervix before 20 weeks and at 20-24 weeks was 18.9 and 22.7 weeks, respectively. Women diagnosed before 20 weeks had a higher rate of PTD at < 28 weeks (76.9% vs. 30.9%; P < 0.001) and at < 32 weeks (80.8% vs. 48.1%; P = 0.004), and a shorter median diagnosis-to-delivery interval (21 vs. 61.5 days, P = 0.003) than those diagnosed at 20-24 weeks. The rate of amniotic fluid sludge was higher among patients diagnosed with a short cervix at < 20 weeks of gestation than in those in whom it was diagnosed between 20 and 24 weeks (92.3% vs. 48.2%; P < 0.001). Conclusions Asymptomatic women with a sonographic cervical length of <= 15 mm diagnosed before 20 weeks of gestation have a dramatic and significantly higher risk of early preterm delivery than women diagnosed at 20-24 weeks. These findings can be helpful to physicians in counseling these patients, and may suggest different mechanisms of disease leading to a sonographic short cervix before or after 20 weeks of gestation. JF - Ultrasound in Obstetrics and Gynecology AU - Vaisbuch, E AU - Romero, R AU - Erez, O AU - Kusanovic, J P AU - Mazaki-Tovi, S AU - Gotsch, F AU - Romero, V AU - Ward, C AU - Chaiworapongsa, T AU - Mittal, P AU - Sorokin, Y AU - Hassan, S S AD - Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD and Detroit, MI, USA, evaisbuch@med.wayne.edu Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 471 EP - 481 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 36 IS - 4 SN - 1469-0705, 1469-0705 KW - Biotechnology and Bioengineering Abstracts KW - Amniotic fluid KW - Cervix KW - Gestational age KW - Gynecology KW - Obstetrics KW - Population studies KW - Risk factors KW - Sludges KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017976120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=Clinical+significance+of+early+%28%26lt%3B+20+weeks%29+vs.+late+%2820-24+weeks%29+detection+of+sonographic+short+cervix+in+asymptomatic+women+in+the+mid-trimester&rft.au=Vaisbuch%2C+E%3BRomero%2C+R%3BErez%2C+O%3BKusanovic%2C+J+P%3BMazaki-Tovi%2C+S%3BGotsch%2C+F%3BRomero%2C+V%3BWard%2C+C%3BChaiworapongsa%2C+T%3BMittal%2C+P%3BSorokin%2C+Y%3BHassan%2C+S+S&rft.aulast=Vaisbuch&rft.aufirst=E&rft.date=2010-10-01&rft.volume=36&rft.issue=4&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=14690705&rft_id=info:doi/10.1002%2Fuog.7673 L2 - http://onlinelibrary.wiley.com/doi/10.1002/uog.7673/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Amniotic fluid; Gestational age; Gynecology; Sludges; Risk factors; Population studies; Cervix; Obstetrics; Ultrasound DO - http://dx.doi.org/10.1002/uog.7673 ER - TY - JOUR T1 - 13C MRS of occipital and frontal lobes at 3 T using a volume coil for stochastic proton decoupling AN - 1017967546; 16700604 AB - Previously, we devised a novel strategy for in vivo13C MRS using [2-13C]glucose infusion and low-power proton decoupling, and proposed that this strategy could be used to acquire 13C MR spectra from the frontal lobe of the human brain. Here, we demonstrate, for the first time, in vivo13C MRS of human frontal lobe acquired at 3 T. Because the primary metabolites of [2-13C]glucose can be decoupled using very-low-radiofrequency power, we used a volume coil for proton decoupling in this study. The homogeneous B1 field of the volume coil was found to significantly enhance the decoupling efficiency of the stochastic decoupling sequence. Detailed specific absorption rates inside the human head were analyzed using the finite difference time domain method to ensure experimental safety. In vivo13C spectra from the occipital and frontal lobes of the human brain were obtained. At a decoupling power of 30W (time-averaged power, 2.45W), the spectra from the occipital lobe showed well-resolved spectral resolution and excellent signal-to-noise ratio. Although frontal lobe 13C spectra were affected by local B0 field inhomogeneity, we demonstrated that the spectral quality could be improved using post-acquisition data processing. In particular, we showed that the frontal lobe glutamine C5 at 178.5ppm and aspartate C4 at 178.3ppm could be spectrally resolved with effective proton decoupling and B0 field correction. Because of its large spatial coverage, volume coil decoupling provides the potential to acquire 13C MRS from more than one brain region simultaneously. JF - NMR in Biomedicine AU - Li, Shizhe AU - Zhang, Yan AU - Wang, Shumin AU - Araneta, Maria Ferraris AU - Johnson, Christopher S AU - Xiang, Yun AU - Innis, Robert B AU - Shen, Jun AD - Magnetic Resonance Spectroscopy Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA, shenj@mail.nih.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 977 EP - 985 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 23 IS - 8 SN - 1099-1492, 1099-1492 KW - Biotechnology and Bioengineering Abstracts KW - Glutamine KW - Data processing KW - Head KW - Frontal lobe KW - Protons KW - Brain KW - N.M.R. KW - Metabolites KW - Occipital lobe KW - Stochasticity KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017967546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=13C+MRS+of+occipital+and+frontal+lobes+at+3+T+using+a+volume+coil+for+stochastic+proton+decoupling&rft.au=Li%2C+Shizhe%3BZhang%2C+Yan%3BWang%2C+Shumin%3BAraneta%2C+Maria+Ferraris%3BJohnson%2C+Christopher+S%3BXiang%2C+Yun%3BInnis%2C+Robert+B%3BShen%2C+Jun&rft.aulast=Li&rft.aufirst=Shizhe&rft.date=2010-10-01&rft.volume=23&rft.issue=8&rft.spage=977&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=10991492&rft_id=info:doi/10.1002%2Fnbm.1524 L2 - http://onlinelibrary.wiley.com/doi/10.1002/nbm.1524/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Glutamine; Data processing; Head; Protons; Frontal lobe; Brain; Metabolites; N.M.R.; Occipital lobe; Stochasticity DO - http://dx.doi.org/10.1002/nbm.1524 ER - TY - JOUR T1 - Early life inorganic lead exposure induces testicular teratoma and renal and urinary bladder preneoplasia in adult metallothionein-knockout mice but not in wild type mice. AN - 748955546; 20600549 AB - Inorganic lead compounds are carcinogenic in animals and have carcinogenic potential in humans. In mice, lead (Pb) is a transplacental carcinogen in the kidney. Metallothionein (MT) is a metal-binding protein that can reduce the toxicity of various metals, including Pb, either by direct sequestration or as an antioxidant for metals that generate reactive oxygen species. Although MT appears to reduce Pb carcinogenicity in adult mice it is unknown how MT deficiency may affect Pb carcinogenicity from early life exposure. Thus, groups (n=10) of pregnant MT-I/II double knockout (MT-null) or 129/SVJ MT wild type (WT) mice were exposed to Pb acetate in the drinking water (0, 2000, 4000ppm Pb) from gestation day 8 through birth and during lactation. Maternal drinking water Pb exposure continued to wean at 4 weeks of age and the male offspring were then directly exposed to Pb until 8 weeks of age and observed until 2 years old. High dose (4000ppm) but not low dose (2000ppm) Pb reduced survival in the latter part of the study in both MT-null and WT mice. In MT-null mice, but not WT, early life Pb exposure caused a dose-related increase in testicular teratomas, to a maximum incidence of 28% compared to control (4%). Pb-induced renal cystic hyperplasia, considered preneoplastic, was a prominent occurrence in MT-null mice but nearly absent in WT mice. Pb dose-related increases in renal cystic hyperplasia occurred in adult MT-null with early life exposure with maximal incidence of 52%. Pb-treated MT-null mice also showed dose-related increases in urinary bladder hyperplasia with occasional papilloma that were absent in WT mice. Thus, MT deficiency made mice more sensitive to early life Pb exposure with regard to testes tumors, and renal and urinary bladder preneoplastic lesions. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Tokar, Erik J AU - Diwan, Bhalchandra A AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2010/09/30/ PY - 2010 DA - 2010 Sep 30 SP - 5 EP - 10 VL - 276 IS - 1 KW - Carcinogens, Environmental KW - 0 KW - Lead KW - 2P299V784P KW - Metallothionein KW - 9038-94-2 KW - Index Medicus KW - Animals KW - Hyperplasia -- chemically induced KW - Teratoma -- chemically induced KW - Dose-Response Relationship, Drug KW - Precancerous Conditions -- chemically induced KW - Urinary Bladder Diseases -- chemically induced KW - Mice KW - Kidney Diseases, Cystic -- chemically induced KW - Testicular Neoplasms -- chemically induced KW - Male KW - Female KW - Prenatal Exposure Delayed Effects KW - Pregnancy KW - Mice, Knockout KW - Maternal Exposure -- adverse effects KW - Carcinogens, Environmental -- administration & dosage KW - Lead -- toxicity KW - Lead -- administration & dosage KW - Metallothionein -- genetics KW - Carcinogens, Environmental -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748955546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Early+life+inorganic+lead+exposure+induces+testicular+teratoma+and+renal+and+urinary+bladder+preneoplasia+in+adult+metallothionein-knockout+mice+but+not+in+wild+type+mice.&rft.au=Tokar%2C+Erik+J%3BDiwan%2C+Bhalchandra+A%3BWaalkes%2C+Michael+P&rft.aulast=Tokar&rft.aufirst=Erik&rft.date=2010-09-30&rft.volume=276&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2010.06.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-08 N1 - Date created - 2010-08-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1995 Mar 10;270(10):5506-10 [7890668] Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):584-8 [8290567] Cancer Res. 1995 Nov 15;55(22):5265-71 [7585586] Cancer Lett. 1996 Feb 27;100(1-2):31-6 [8620450] Cancer Res. 2004 Nov 1;64(21):7766-72 [15520181] Int J Toxicol. 2005 Jul-Aug;24(4):215-20 [16126615] J Trace Elem Med Biol. 2005;19(1):13-7 [16240666] Cancer Res. 2006 Feb 1;66(3):1337-45 [16452187] Nat Methods. 2006 Mar;3(3):179-81 [16489334] Int J Cancer. 2006 Jul 1;119(1):28-32 [16432836] Toxicol Appl Pharmacol. 2006 Sep 15;215(3):295-305 [16712894] J Intern Med. 2007 May;261(5):461-71 [17444885] Environ Health Perspect. 2007 Jul;115(7):1101-6 [17637929] Toxicol Appl Pharmacol. 2007 Aug 1;222(3):271-80 [17306315] Mol Cell Endocrinol. 2008 Jun 25;288(1-2):111-8 [18420341] Cancer Res. 2008 Oct 15;68(20):8278-85 [18922899] Toxicol Appl Pharmacol. 2008 Nov 15;233(1):92-9 [18325558] Toxicol Appl Pharmacol. 2009 Aug 1;238(3):215-20 [19362100] Toxicol Sci. 2009 Sep;111(1):100-8 [19542206] Environ Health Perspect. 2010 Jan;118(1):108-15 [20056578] J Natl Cancer Inst. 2010 May 5;102(9):638-49 [20339138] Toxicol Appl Pharmacol. 1995 May;132(1):115-21 [7747274] Cancer Res. 1993 Sep 1;53(17):3874-6 [8358711] Toxicology. 2000 Apr 7;145(1):51-62 [10771131] Environ Health Perspect. 2000 Jun;108 Suppl 3:573-94 [10852857] J Cell Sci. 2000 Oct;113 Pt 19:3463-72 [10984437] J Toxicol Environ Health A. 2000 Dec 15;61(7):553-67 [11127411] Br J Nutr. 2000 Nov;84(5):747-56 [11177190] Am J Pathol. 2002 Mar;160(3):1047-56 [11891201] Tohoku J Exp Med. 2002 Jan;196(1):9-22 [12498322] Development. 2003 Apr;130(8):1691-700 [12620992] Environ Health Perspect. 2003 Apr;111(4):389-94 [12676588] J Toxicol Environ Health. 1982 Jan;9(1):77-86 [7062352] Toxicology. 1986 Mar;38(3):261-8 [3952754] Int Arch Occup Environ Health. 1988;60(6):413-7 [3410551] Arch Neurol. 1992 Jul;49(7):721-4 [1497498] Carcinogenesis. 1992 Aug;13(8):1351-7 [1499087] Comment In: J Urol. 2011 May;185(5):1975-6 [22088742] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.tox.2010.06.006 ER - TY - JOUR T1 - Physical activity, sedentary behaviours, and the prevention of endometrial cancer AN - 954574779; 13762427 AB - Physical activity has been hypothesised to reduce endometrial cancer risk, but this relationship has been difficult to confirm because of a limited number of prospective studies. However, recent publications from five cohort studies, which together comprise 2663 out of 3463 cases in the published literature for analyses of recreational physical activity, may help resolve this question. To synthesise these new data, we conducted a meta-analysis of prospective studies published through to December 2009. We found that physical activity was clearly associated with reduced risk of endometrial cancer, with active women having an approximately 30% lower risk than inactive women. Owing to recent interest in sedentary behaviour, we further investigated sitting time in relation to endometrial cancer risk using data from the NIH-AARP Diet and Health Study. We found that, independent of the level of moderate-vigorous physical activity, greater sitting time was associated with increased endometrial cancer risk. Thus, limiting time in sedentary behaviours may complement increasing level of moderate-vigorous physical activity as a means of reducing endometrial cancer risk. Taken together with the established biological plausibility of this relation, the totality of evidence now convincingly indicates that physical activity prevents or reduces risk of endometrial cancer. JF - British Journal of Cancer AU - Moore, S C AU - Gierach, G L AU - Schatzkin, A AU - Matthews, C E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20892, USA Y1 - 2010/09/28/ PY - 2010 DA - 2010 Sep 28 SP - 933 EP - 938 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 103 IS - 7 SN - 0007-0920, 0007-0920 KW - Physical Education Index KW - Preventive health KW - Analysis KW - Women KW - Meta analysis KW - Health (behavior) KW - Exercise KW - Sitting KW - Diet KW - Cancer KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954574779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Physical+activity%2C+sedentary+behaviours%2C+and+the+prevention+of+endometrial+cancer&rft.au=Moore%2C+S+C%3BGierach%2C+G+L%3BSchatzkin%2C+A%3BMatthews%2C+C+E&rft.aulast=Moore&rft.aufirst=S&rft.date=2010-09-28&rft.volume=103&rft.issue=7&rft.spage=933&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605902 LA - English DB - Physical Education Index N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Preventive health; Analysis; Meta analysis; Women; Health (behavior); Diet; Sitting; Exercise; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6605902 ER - TY - JOUR T1 - Insulin-like growth factors and liver cancer risk in male smokers AN - 899138771; 13762404 AB - Background:The liver is the primary source of circulating insulin-like growth factor (IGF)-I, yet the relation between IGFs and liver cancer is uncertain. Methods:In a case-cohort study within a cohort of 29133 male smokers we examined associations of serum IGF-I and IGF binding protein (IGFBP)-3 with liver cancer (50 cases). Results:Nonlinear associations between liver cancer and IGF-I and IGFBP-3 were observed (P=0.04 and P<0.01, respectively), strongest association at lowest levels (odds ratio (OR)=0.2, 95% confidence interval (CI)=0.1-0.7 for 80 vs 30ngml super(-1) of IGF-I; OR=0.2, 95% CI=0.1-0.6 for 1400 vs 700ngml super(-1) of IGFBP-3). Conclusions:Low IGF-I and IGFBP-3 levels in male smokers are associated with increased risk of liver cancer. JF - British Journal of Cancer AU - Major, J M AU - Stolzenberg-Solomon, R Z AU - Pollak, M N AU - Snyder, K AU - Virtamo, J AU - Albanes, D AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20852, USA Y1 - 2010/09/28/ PY - 2010 DA - 2010 Sep 28 SP - 1089 EP - 1092 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 103 IS - 7 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Liver KW - males KW - Proteins KW - growth factors KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899138771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Insulin-like+growth+factors+and+liver+cancer+risk+in+male+smokers&rft.au=Major%2C+J+M%3BStolzenberg-Solomon%2C+R+Z%3BPollak%2C+M+N%3BSnyder%2C+K%3BVirtamo%2C+J%3BAlbanes%2C+D&rft.aulast=Major&rft.aufirst=J&rft.date=2010-09-28&rft.volume=103&rft.issue=7&rft.spage=1089&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605842 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Liver; Proteins; males; growth factors; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6605842 ER - TY - JOUR T1 - Glucose uptake regulation in E. coli by the small RNA SgrS: comparative analysis of E. coli K-12 (JM109 and MG1655) and E. coli B (BL21) AN - 839693336; 13969592 AB - The effect of high glucose concentration on the transcription levels of the small RNA SgrS and the messenger RNA ptsG, (encoding the glucose transporter IICBGlc), was studied in both E. coli K-12 (MG1655 and JM109) and E. coli B (BL21). It is known that the transcription level of sgrS increases when E. coli K-12 (MG1655 and JM109) is exposed to the non-metabolized glucose alpha methyl glucoside (aMG) or when the bacteria with a defective glycolysis pathway is grown in presence of glucose. The increased level of sRNA SgrS reduces the level of the ptsG mRNA and consequently lowers the level of the glucose transporter IICBGlc. The suggested trigger for this action is the accumulation of the corresponding phospho-sugars. In the course of the described work, it was found that E. coli B (BL21) and E. coli K-12 (JM109 and MG1655) responded similarly to aMG: both strains increased SgrS transcription and reduced ptsG transcription. However, the two strains reacted differently to high glucose concentration (40 g/L). E. coli B (BL21) reacted by increasing sgrS transcription and reducing ptsG transcription while E. coli K-12 (JM109 and MG1655) did not respond to the high glucose concentration, and, therefore, transcription of sgrS was not detected and ptsG mRNA level was not affected. The results suggest that E. coli B (BL21) tolerates high glucose concentration not only by its more efficient central carbon metabolism, but also by controlling the glucose transport into the cells regulated by the sRNA SgrS, which may suggest a way to control glucose consumption and increase its efficient utilization. JF - Microbial Cell Factories AU - Negrete, Alejandro AU - Ng, Weng-Ian AU - Shiloach, Joseph AD - Biotechnology Core Laboratory, NIDDK, NIH, Bethesda, MD USA Y1 - 2010/09/28/ PY - 2010 DA - 2010 Sep 28 SP - 75 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 9 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Carbon KW - Glucose KW - Glucose transport KW - Glucose transporter KW - Glycolysis KW - Metabolism KW - Transcription KW - glucosides KW - mRNA KW - Escherichia coli KW - W 30940:Products KW - A 01490:Miscellaneous KW - J 02320:Cell Biology KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839693336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Cell+Factories&rft.atitle=Glucose+uptake+regulation+in+E.+coli+by+the+small+RNA+SgrS%3A+comparative+analysis+of+E.+coli+K-12+%28JM109+and+MG1655%29+and+E.+coli+B+%28BL21%29&rft.au=Negrete%2C+Alejandro%3BNg%2C+Weng-Ian%3BShiloach%2C+Joseph&rft.aulast=Negrete&rft.aufirst=Alejandro&rft.date=2010-09-28&rft.volume=9&rft.issue=&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Microbial+Cell+Factories&rft.issn=1475-2859&rft_id=info:doi/10.1186%2F1475-2859-9-75 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2013-01-25 N1 - SubjectsTermNotLitGenreText - Carbon; Glucose transport; Glucose; Transcription; glucosides; Glycolysis; Glucose transporter; Metabolism; mRNA; Escherichia coli DO - http://dx.doi.org/10.1186/1475-2859-9-75 ER - TY - JOUR T1 - Risk of breast cancer according to clinicopathologic features among long-term survivors of Hodgkin's lymphoma treated with radiotherapy AN - 762280038; 13762424 AB - Background:It is unknown whether breast cancer (BC) characteristics among young women treated with radiotherapy (RT) for Hodgkin's lymphoma (HL) differ from sporadic BC. Methods:Using population-based data, we calculated BC risk following HL according to clinicopathologic features. Results:Compared with BC in the general population, risks of oestrogen receptor (ER)-positive/progesterone receptor (PR)-positive and ER-negative/PR-negative BC in young, irradiated HL survivors were increased five-fold (95% confidence interval (CI)=3.81-6.35) and nine-fold (95% CI=6.93-12.25), respectively. Among 15-year survivors, relative risk of ER-negative/PR-negative BC exceeded by two-fold (P=0.002) than that of ER-positive/PR-positive BC. Conclusion:Radiotherapy may disproportionately contribute to the development of BC with adverse prognostic features among young HL survivors. JF - British Journal of Cancer AU - Dores, G M AU - Anderson, W F AU - Beane Freeman, L E AU - Fraumeni, J F AU - Curtis, R E AD - [1] Medical Service, Department of Veterans Affairs Medical Center, 921 N.E. 13th Street, Oklahoma City, OK 73104, USA [2] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Bethesda, MD 20892, USA Y1 - 2010/09/28/ PY - 2010 DA - 2010 Sep 28 SP - 1081 EP - 1084 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 103 IS - 7 SN - 0007-0920, 0007-0920 KW - Immunology Abstracts; Toxicology Abstracts; Risk Abstracts KW - Risk assessment KW - Progesterone receptors KW - Hodgkin's disease KW - Data processing KW - Radiotherapy KW - Breast cancer KW - lymphoma KW - radiotherapy KW - Estrogen receptors KW - Cancer KW - X 24390:Radioactive Materials KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762280038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Risk+of+breast+cancer+according+to+clinicopathologic+features+among+long-term+survivors+of+Hodgkin%27s+lymphoma+treated+with+radiotherapy&rft.au=Dores%2C+G+M%3BAnderson%2C+W+F%3BBeane+Freeman%2C+L+E%3BFraumeni%2C+J+F%3BCurtis%2C+R+E&rft.aulast=Dores&rft.aufirst=G&rft.date=2010-09-28&rft.volume=103&rft.issue=7&rft.spage=1081&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605877 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Risk assessment; Progesterone receptors; Data processing; Hodgkin's disease; Breast cancer; Radiotherapy; Estrogen receptors; radiotherapy; lymphoma; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6605877 ER - TY - JOUR T1 - Association of Telomere Length of Peripheral Blood Leukocytes With Hematopoietic Relapse, Malignant Transformation, and Survival in Severe Aplastic Anemia AN - 762272978; 13813520 AB - CONTEXT: Critically short telomeres produce apoptosis, cell senescence, and chromosomal instability in tissue culture and animal models. Variations in telomere length have been reported in severe aplastic anemia but their clinical significance is unknown. OBJECTIVE: To investigate the relationship between telomere length and clinical outcomes in severe aplastic anemia. DESIGN, SETTING, AND PATIENTS: Single institution analysis of 183 patients with severe aplastic anemia who were treated in sequential prospective protocols at the National Institutes of Health from 2000 to 2008. The pretreatment leukocyte age-adjusted telomere length of patients with severe aplastic anemia consecutively enrolled in immunosuppression protocols with antithymocyte globulin plus cyclosporine for correlation with clinical outcomes were analyzed. MAIN OUTCOME MEASURES: Hematologic response, relapse, clonal evolution, and survival. RESULTS: There was no relationship between hematologic response and telomere length with response rates of 56.5% of 46 patients in the first, 54.3% of 46 in the second, 60% of 45 in the third, and 56.5% of 46 in the fourth quartiles. Multivariate analysis demonstrated that telomere length was associated with relapse, clonal evolution, and mortality. Evaluated as a continuous variable, telomere length inversely correlated with the probability of hematologic relapse (hazard ratio [HR], 0.16; 95% confidence interval [CI], 0.03-0.69; P = .01). The probability of clonal evolution was higher in patients in the first quartile (24.5%; 95% CI, 8.7%-37.5%) than in quartiles 2 through 4 (8.4%; 95% CI, 3.2%-13.3%; P = .009), and evolution to monosomy 7 or complex cytogenetics was more common in the first quartile (18.8%; 95% CI, 3.5%-31.6%) than in quartiles 2 through 4 (4.5%; 95% CI, 0.5%-8.2%; P = .002). Survival between these 2 groups differed, with 66% (95% CI, 52.9%-82.5%) surviving 6 years in the first quartile compared with 83.8% (95% CI, 77.3%-90.9%) in quartiles 2 through 4 (P = .008). CONCLUSION: In a cohort of patients with severe aplastic anemia receiving immunosuppressive therapy, telomere length was unrelated to response but was associated with risk of relapse, clonal evolution, and overall survival. JF - JAMA: Journal of the American Medical Association AU - Scheinberg, Phillip AU - Cooper, James N AU - Sloand, Elaine M AU - Wu, Colin O AU - Calado, Rodrigo T AU - Young, Neal S AD - Author Affiliations: Hematology Branch (Drs Scheinberg, Cooper, Sloand, Calado, and Young) and Office of Biostatistics Research (Dr Wu), National Heart, Lung, and Blood Institute and Clinical Research Training Program (Dr Cooper), National Institutes of Health, Bethesda, Maryland Y1 - 2010/09/22/ PY - 2010 DA - 2010 Sep 22 SP - 1358 EP - 1364 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 304 IS - 12 SN - 0098-7484, 0098-7484 KW - Genetics Abstracts; Immunology Abstracts; Risk Abstracts KW - Cell survival KW - Monosomy KW - Transformation KW - anemia KW - Apoptosis KW - Animal models KW - Survival KW - Immunosuppressive agents KW - Cyclosporins KW - Genomic instability KW - Multivariate analysis KW - Mortality KW - Antilymphocyte serum KW - Leukocytes KW - Peripheral blood KW - Tissue culture KW - Telomeres KW - senescence KW - Hemopoiesis KW - Senescence KW - survival KW - Aplastic anemia KW - Evolution KW - Immunosuppression KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762272978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Association+of+Telomere+Length+of+Peripheral+Blood+Leukocytes+With+Hematopoietic+Relapse%2C+Malignant+Transformation%2C+and+Survival+in+Severe+Aplastic+Anemia&rft.au=Scheinberg%2C+Phillip%3BCooper%2C+James+N%3BSloand%2C+Elaine+M%3BWu%2C+Colin+O%3BCalado%2C+Rodrigo+T%3BYoung%2C+Neal+S&rft.aulast=Scheinberg&rft.aufirst=Phillip&rft.date=2010-09-22&rft.volume=304&rft.issue=12&rft.spage=1358&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Transformation; Monosomy; Cell survival; Mortality; Apoptosis; Antilymphocyte serum; Leukocytes; Animal models; Survival; Peripheral blood; Tissue culture; Cyclosporins; Immunosuppressive agents; Telomeres; Genomic instability; Multivariate analysis; Hemopoiesis; Senescence; Aplastic anemia; Evolution; Immunosuppression; anemia; senescence; survival ER - TY - JOUR T1 - LocusZoom: regional visualization of genome-wide association scan results AN - 831146393; 13809963 AB - Summary: Genome-wide association studies (GWAS) have revealed hundreds of loci associated with common human genetic diseases and traits. We have developed a web-based plotting tool that provides fast visual display of GWAS results in a publication-ready format. LocusZoom visually displays regional information such as the strength and extent of the association signal relative to genomic position, local linkage disequilibrium (LD) and recombination patterns and the positions of genes in the region.Availability: LocusZoom can be accessed from a web interface at http://csg.sph.umich.edu/locuszoom. Users may generate a single plot using a web form, or many plots using batch mode. The software utilizes LD information from HapMap Phase II (CEU, YRI and JPT+CHB) or 1000 Genomes (CEU) and gene information from the UCSC browser, and will accept SNP identifiers in dbSNP or 1000 Genomes format. Single plots are generated in 620 s. Source code and associated databases are available for download and local installation, and full documentation is available online.Contact: cristen super(m)ich.edu JF - Bioinformatics AU - Pruim, Randall J AU - Welch, Ryan P AU - Sanna, Serena AU - Teslovich, Tanya M AU - Chines, Peter S AU - Gliedt, Terry P AU - Boehnke, Michael AU - Abecasis, Goncalo R AU - Willer, Cristen J AD - super(1)Department of Mathematics and Statistics, Calvin College, Grand Rapids, MI 49546, super(2)Department of Biostatistics and Center for Statistical Genetics, University of Michigan, super(3)Bioinformatics Graduate Program, The University of Michigan Medical School, Ann Arbor, MI 48109, USA, super(4)Istituto di Neurogenetica e Neurofarmacologia (INN), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy 09042 and super(5)National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA Y1 - 2010/09/15/ PY - 2010 DA - 2010 Sep 15 SP - 2336 EP - 2337 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 26 IS - 18 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Linkage disequilibrium KW - Computer programs KW - Recombination KW - Databases KW - software KW - Single-nucleotide polymorphism KW - Information processing KW - Bioinformatics KW - genomics KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/831146393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=LocusZoom%3A+regional+visualization+of+genome-wide+association+scan+results&rft.au=Pruim%2C+Randall+J%3BWelch%2C+Ryan+P%3BSanna%2C+Serena%3BTeslovich%2C+Tanya+M%3BChines%2C+Peter+S%3BGliedt%2C+Terry+P%3BBoehnke%2C+Michael%3BAbecasis%2C+Goncalo+R%3BWiller%2C+Cristen+J&rft.aulast=Pruim&rft.aufirst=Randall&rft.date=2010-09-15&rft.volume=26&rft.issue=18&rft.spage=2336&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtq419 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Genomes; Databases; Recombination; Computer programs; Linkage disequilibrium; software; Single-nucleotide polymorphism; Information processing; genomics; Bioinformatics DO - http://dx.doi.org/10.1093/bioinformatics/btq419 ER - TY - JOUR T1 - Metronomic administration of zoledronic acid and taxotere combination in castration resistant prostate cancer patients: phase I ZANTE trial. AN - 808454576; 20657175 AB - Docetaxel (DTX) and zoledronic acid (ZOL) are effective in patients with hormone resistant prostate cancer (HRPC) with bone metastases. A phase I clinical trial of metronomic administration of Zoledronic Acid AN d TaxoterE combination (ZANTE trial) in 2 different sequences was conducted in HRPC. The maximum tolerated dose was not achieved with sequence A. Two patients at third level of sequence B developed dose limiting toxicity. A disease control was obtained in six out of nine patients treated with sequence A, where a decrease of biological markers and PSA were also observed. No evidence of anti-tumor activity was observed in patients treated with sequence B. Twenty-two patients enrolled into the study (median age: 73 years; range: 43-80) received one of three escalated doses of DTX (30, 40 and 50 mg/m(2)) in combination with a fixed dose of ZOL (2 mg), both administered every 14 days in two different sequences: DTX at the day 1 followed by ZOL at the day 2 (sequence A) or the reverse (sequence B). Patients were evaluated for adverse events and serum IL-8, MMP-2 and MMP-9 were evaluated prior and after therapy with the two sequences of administration of DTX and ZOL. The bi-weekly combination of DTX (50 mg/m(2)) followed by ZOL was feasible and show promising anti-tumor activity. JF - Cancer biology & therapy AU - Facchini, Gaetano AU - Caraglia, Michele AU - Morabito, Alessandro AU - Marra, Monica AU - Piccirillo, Maria C AU - Bochicchio, Anna M AU - Striano, Stefano AU - Marra, Luigi AU - Nasti, Guglielmo AU - Ferrari, Ettore AU - Leopardo, Davide AU - Vitale, Giovanni AU - Gentilini, Davide AU - Tortoriello, Anna AU - Catalano, Alfonso AU - Budillon, Alfredo AU - Perrone, Franco AU - Iaffaioli, Rosario V AD - Genito-Urinary Department, National Cancer Institute Fondazione G Pascale, Naples, Italy. Y1 - 2010/09/15/ PY - 2010 DA - 2010 Sep 15 SP - 543 EP - 548 VL - 10 IS - 6 KW - Diphosphonates KW - 0 KW - Imidazoles KW - Interleukin-8 KW - Taxoids KW - docetaxel KW - 15H5577CQD KW - zoledronic acid KW - 6XC1PAD3KF KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Matrix Metalloproteinase 2 KW - EC 3.4.24.24 KW - Matrix Metalloproteinase 9 KW - EC 3.4.24.35 KW - Index Medicus KW - Drug Administration Schedule KW - Infusions, Intravenous KW - Diphosphonates -- adverse effects KW - Dose-Response Relationship, Drug KW - Humans KW - Imidazoles -- administration & dosage KW - Anemia -- chemically induced KW - Taxoids -- adverse effects KW - Neutropenia -- chemically induced KW - Aged KW - Interleukin-8 -- blood KW - Taxoids -- administration & dosage KW - Orchiectomy KW - Matrix Metalloproteinase 2 -- blood KW - Fever -- chemically induced KW - Feasibility Studies KW - Matrix Metalloproteinase 9 -- blood KW - Aged, 80 and over KW - Diphosphonates -- administration & dosage KW - Prostate-Specific Antigen -- blood KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Male KW - Imidazoles -- adverse effects KW - Prostatic Neoplasms -- surgery KW - Prostatic Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/808454576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=Metronomic+administration+of+zoledronic+acid+and+taxotere+combination+in+castration+resistant+prostate+cancer+patients%3A+phase+I+ZANTE+trial.&rft.au=Facchini%2C+Gaetano%3BCaraglia%2C+Michele%3BMorabito%2C+Alessandro%3BMarra%2C+Monica%3BPiccirillo%2C+Maria+C%3BBochicchio%2C+Anna+M%3BStriano%2C+Stefano%3BMarra%2C+Luigi%3BNasti%2C+Guglielmo%3BFerrari%2C+Ettore%3BLeopardo%2C+Davide%3BVitale%2C+Giovanni%3BGentilini%2C+Davide%3BTortoriello%2C+Anna%3BCatalano%2C+Alfonso%3BBudillon%2C+Alfredo%3BPerrone%2C+Franco%3BIaffaioli%2C+Rosario+V&rft.aulast=Facchini&rft.aufirst=Gaetano&rft.date=2010-09-15&rft.volume=10&rft.issue=6&rft.spage=543&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=1555-8576&rft_id=info:doi/10.4161%2Fcbt.10.6.12611 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-04-18 N1 - Date created - 2010-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4161/cbt.10.6.12611 ER - TY - JOUR T1 - Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers. AN - 755162301; 20823146 AB - Tumor cells are often deficient in DNA damage response (DDR) pathways, and anticancer therapies are commonly based on genotoxic treatments using radiation and/or drugs that damage DNA directly or interfere with DNA metabolism, leading to the formation of DNA double-strand breaks (DSB), and ultimately to cell death. Because DSBs induce the phosphorylation of histone H2AX (γH2AX) in the chromatin flanking the break site, an antibody directed against γH2AX can be employed to measure DNA damage levels before and after patient treatment. Poly(ADP-ribose) polymerases (PARP1 and PARP2) are also activated by DNA damage, and PARP inhibitors show promising activity in cancers with defective homologous recombination (HR) pathways for DSB repair. Ongoing clinical trials are testing combinations of PARP inhibitors with DNA damaging agents. Poly(ADP-ribosylation), abbreviated as PAR, can be measured in clinical samples and used to determine the efficiency of PARP inhibitors. This review summarizes the roles of γH2AX and PAR in the DDR, and their use as biomarkers to monitor drug response and guide clinical trials, especially phase 0 clinical trials. We also discuss the choices of relevant samples for γH2AX and PAR analyses. ©2010 AACR. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Redon, Christophe E AU - Nakamura, Asako J AU - Zhang, Yong-Wei AU - Ji, Jiuping Jay AU - Bonner, William M AU - Kinders, Robert J AU - Parchment, Ralph E AU - Doroshow, James H AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2010/09/15/ PY - 2010 DA - 2010 Sep 15 SP - 4532 EP - 4542 VL - 16 IS - 18 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Biomarkers, Pharmacological KW - Biomarkers, Tumor KW - H2AFX protein, human KW - Histones KW - Poly(ADP-ribose) Polymerase Inhibitors KW - Poly Adenosine Diphosphate Ribose KW - 26656-46-2 KW - Poly(ADP-ribose) Polymerases KW - EC 2.4.2.30 KW - Index Medicus KW - Animals KW - Medical Oncology -- methods KW - Humans KW - Prognosis KW - Poly(ADP-ribose) Polymerases -- physiology KW - Antineoplastic Agents -- therapeutic use KW - Poly(ADP-ribose) Polymerases -- metabolism KW - Models, Biological KW - DNA Damage -- genetics KW - Antineoplastic Agents -- pharmacology KW - DNA Damage -- drug effects KW - Neoplasms -- drug therapy KW - Poly Adenosine Diphosphate Ribose -- analysis KW - Neoplasms -- genetics KW - Biomarkers, Tumor -- metabolism KW - Biomarkers, Tumor -- physiology KW - Biomarkers, Pharmacological -- analysis KW - Neoplasms -- diagnosis KW - Biomarkers, Pharmacological -- metabolism KW - Histones -- metabolism KW - Biomarkers, Tumor -- analysis KW - Poly Adenosine Diphosphate Ribose -- physiology KW - Poly Adenosine Diphosphate Ribose -- metabolism KW - Histones -- genetics KW - Histones -- physiology KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755162301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Histone+gammaH2AX+and+poly%28ADP-ribose%29+as+clinical+pharmacodynamic+biomarkers.&rft.au=Redon%2C+Christophe+E%3BNakamura%2C+Asako+J%3BZhang%2C+Yong-Wei%3BJi%2C+Jiuping+Jay%3BBonner%2C+William+M%3BKinders%2C+Robert+J%3BParchment%2C+Ralph+E%3BDoroshow%2C+James+H%3BPommier%2C+Yves&rft.aulast=Redon&rft.aufirst=Christophe&rft.date=2010-09-15&rft.volume=16&rft.issue=18&rft.spage=4532&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-10-0523 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-02 N1 - Date created - 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Oct;58(10):1009-15 [16189143] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-10-0523 ER - TY - JOUR T1 - The neurovirulence and neuroinvasiveness of chimeric tick-borne encephalitis/dengue virus can be attenuated by introducing defined mutations into the envelope and NS5 protein genes and the 3' non-coding region of the genome AN - 754896611; 13525436 AB - Tick-borne encephalitis (TBE) is a severe disease affecting thousands of people throughout Eurasia. Despite the use of formalin-inactivated vaccines in endemic areas, an increasing incidence of TBE emphasizes the need for an alternative vaccine that will induce a more durable immunity against TBE virus (TBEV). The chimeric attenuated virus vaccine candidate containing the structural protein genes of TBEV on a dengue virus genetic background (TBEV/DEN4) retains a high level of neurovirulence in both mice and monkeys. Therefore, attenuating mutations were introduced into the envelope (E sub(315)) and NS5 (NS5 sub(654,655)) proteins, and into the 3' non-coding region (30) of TBEV/DEN4. The variant that contained all three mutations (v30/E sub(315)/NS5 sub(654,655)) was significantly attenuated for neuroinvasiveness and neurovirulence and displayed a reduced level of replication and virus-induced histopathology in the brains of mice. The high level of safety in the central nervous system indicates that v30/E sub(315)/NS5 sub(654,655) should be further evaluated as a TBEV vaccine. JF - Virology AU - Engel, Amber R AU - Rumyantsev, Alexander A AU - Maximova, Olga A AU - Speicher, James M AU - Heiss, Brian AU - Murphy, Brian R AU - Pletnev, Alexander G AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA Y1 - 2010/09/15/ PY - 2010 DA - 2010 Sep 15 SP - 243 EP - 252 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 405 IS - 1 SN - 0042-6822, 0042-6822 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; CSA Neurosciences Abstracts; Virology & AIDS Abstracts KW - Flavivirus KW - Tick-borne encephalitis virus KW - Live attenuated vaccine KW - Neurovirulence KW - Dengue virus KW - Genomes KW - Central nervous system KW - Invasiveness KW - Human diseases KW - Disease control KW - Structural proteins KW - Public health KW - Tick-borne encephalitis KW - Endemic species KW - Envelopes KW - Genes KW - Eurasia KW - Mutations KW - Replication KW - Brain KW - Immunity KW - NS5 protein KW - Vaccines KW - Mutation KW - V 22320:Replication KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754896611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=The+neurovirulence+and+neuroinvasiveness+of+chimeric+tick-borne+encephalitis%2Fdengue+virus+can+be+attenuated+by+introducing+defined+mutations+into+the+envelope+and+NS5+protein+genes+and+the+3%27+non-coding+region+of+the+genome&rft.au=Engel%2C+Amber+R%3BRumyantsev%2C+Alexander+A%3BMaximova%2C+Olga+A%3BSpeicher%2C+James+M%3BHeiss%2C+Brian%3BMurphy%2C+Brian+R%3BPletnev%2C+Alexander+G&rft.aulast=Engel&rft.aufirst=Amber&rft.date=2010-09-15&rft.volume=405&rft.issue=1&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2010.06.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Central nervous system; Endemic species; Human diseases; Genes; Replication; Mutations; Disease control; Vaccines; Public health; Genomes; Invasiveness; Neurovirulence; Brain; Immunity; Structural proteins; Tick-borne encephalitis; Envelopes; NS5 protein; Mutation; Dengue virus; Eurasia DO - http://dx.doi.org/10.1016/j.virol.2010.06.014 ER - TY - JOUR T1 - In-Home Coal and Wood Use and Lung Cancer Risk: A Pooled Analysis of the International Lung Cancer Consortium AN - 1677986134; 14160339 AB - Domestic fuel combustion from cooking and heating is an important public health issue because roughly 3 billion people are exposed worldwide. Recently, the International Agency for Research on Cancer classified indoor emissions from household coal combustion as a human carcinogen (group 1) and from biomass fuel (primarily wood) as a probable human carcinogen (group 2A). We pooled seven studies from the International Lung Cancer Consortium (5,105 cases and 6,535 controls) to provide further epidemiological evaluation of the association between in-home solid-fuel use, particularly wood, and lung cancer risk. Using questionnaire data, we classified subjects as predominant solid-fuel users (e.g., coal, wood) or nonsolid-fuel users (e.g., oil, gas, electricity). Unconditional logistic regression was used to estimate the odds ratios (ORs) and to compute 95% confidence intervals (CIs), adjusting for age, sex, education, smoking status, race/ethnicity, and study center. Compared with nonsolid-fuel users, predominant coal users (OR = 1.64; 95% CI, 1.49-1.81), particularly coal users in Asia (OR = 4.93; 95% CI, 3.73-6.52), and predominant wood users in North American and European countries (OR = 1.21; 95% CI, 1.06-1.38) experienced higher risk of lung cancer. The results were similar in never-smoking women and other subgroups. Our results are consistent with previous observations pertaining to in-home coal use and lung cancer risk, support the hypothesis of a carcinogenic potential of in-home wood use, and point to the need for more detailed study of factors affecting these associations. JF - Environmental Health Perspectives AU - Hosgood, HDean AU - Boffetta, Paolo AU - Greenland, Sander AU - Lee, Yuan-Chin Amy AU - McLaughlin, John AU - Seow, Adeline AU - Duell, Eric J AU - Andrew, Angeline S AU - Zaridze, David AU - Szeszenia-Dabrowska, Neonila AU - Rudnai, Peter AU - Lissowska, Jolanta AU - Fabianova, Eleonora AU - Mates, Dana AU - Bencko, Vladimir AU - Foretova, Lenka AU - Janout, Vladimir AU - Morgenstern, Hal AU - Rothman, Nathaniel AU - Hung, Rayjean J AU - Brennan, Paul AU - Lan, Qing AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA Y1 - 2010/09/15/ PY - 2010 DA - 2010 Sep 15 SP - 1743 EP - 1747 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 118 IS - 2 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - coal KW - lung cancer KW - pooled KW - risk factor KW - wood KW - Risk KW - Heating KW - Human KW - Wood KW - Lungs KW - Coal KW - Carcinogens KW - Cancer KW - Combustion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677986134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=In-Home+Coal+and+Wood+Use+and+Lung+Cancer+Risk%3A+A+Pooled+Analysis+of+the+International+Lung+Cancer+Consortium&rft.au=Hosgood%2C+HDean%3BBoffetta%2C+Paolo%3BGreenland%2C+Sander%3BLee%2C+Yuan-Chin+Amy%3BMcLaughlin%2C+John%3BSeow%2C+Adeline%3BDuell%2C+Eric+J%3BAndrew%2C+Angeline+S%3BZaridze%2C+David%3BSzeszenia-Dabrowska%2C+Neonila%3BRudnai%2C+Peter%3BLissowska%2C+Jolanta%3BFabianova%2C+Eleonora%3BMates%2C+Dana%3BBencko%2C+Vladimir%3BForetova%2C+Lenka%3BJanout%2C+Vladimir%3BMorgenstern%2C+Hal%3BRothman%2C+Nathaniel%3BHung%2C+Rayjean+J%3BBrennan%2C+Paul%3BLan%2C+Qing&rft.aulast=Hosgood&rft.aufirst=HDean&rft.date=2010-09-15&rft.volume=118&rft.issue=2&rft.spage=1743&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002217 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1289/ehp.1002217 ER - TY - JOUR T1 - Meat and components of meat and the risk of bladder cancer in the NIH-AARP Diet and Health Study? AN - 1017962837; 16689052 AB - BACKGROUND: Meat could be involved in bladder carcinogenesis via multiple potentially carcinogenic meat-related compounds related to cooking and processing, including nitrate, nitrite, heterocyclic amines (HCAs), and polycyclic aromatic hydrocarbons (PAHs). The authors comprehensively investigated the association between meat and meat components and bladder cancer. METHODS: During 7 years of follow-up, 854 transitional cell bladder-cancer cases were identified among 300,933 men and women who had completed a validated food-frequency questionnaire in the large prospective NIH-AARP Diet and Health Study. The authors estimated intake of nitrate and nitrite from processed meat and HCAs and PAHs from cooked meat by using quantitative databases of measured values. Total dietary nitrate and nitrite were calculated based on literature values. RESULTS: The hazard ratios (HR) and 95% confidence intervals (CI) for red meat (HR for fifth quintile compared with first quintile, 1.22; 95% CI, 0.96-1.54; Ptrend = .07) and the HCA 2-amino-1 methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) (HR, 1.19; 95% CI, 0.95-1.48; Ptrend = .06) conferred a borderline statistically significant increased risk of bladder cancer. Positive associations were observed in the top quintile for total dietary nitrite (HR, 1.28; 95% CI, 1.02-1.61; Ptrend = .06) and nitrate plus nitrite intake from processed meat (HR, 1.29; 95% CI, 1.00-1.67; Ptrend = .11). CONCLUSIONS: These findings provided modest support for an increased risk of bladder cancer with total dietary nitrite and nitrate plus nitrite from processed meat. Results also suggested a positive association between red meat and PhIP and bladder carcinogenesis. Cancer 2010. ? 2010 American Cancer Society. JF - Cancer AU - Ferrucci, Leah M AU - Sinha, Rashmi AU - Ward, Mary H AU - Graubard, Barry I AU - Hollenbeck, Albert R AU - Kilfoy, Briseis A AU - Schatzkin, Arthur AU - Michaud, Dominique S AU - Cross, Amanda J AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, crossa@mail.nih.gov Y1 - 2010/09/15/ PY - 2010 DA - 2010 Sep 15 SP - 4345 EP - 4353 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 116 IS - 18 SN - 1097-0142, 1097-0142 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Amines KW - Cancer KW - Carcinogenesis KW - Carcinogenicity KW - Diets KW - Meat KW - Nitrates KW - Nitrites KW - Urinary bladder KW - cooking KW - meat KW - urinary bladder KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017962837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Meat+and+components+of+meat+and+the+risk+of+bladder+cancer+in+the+NIH-AARP+Diet+and+Health+Study%3F&rft.au=Ferrucci%2C+Leah+M%3BSinha%2C+Rashmi%3BWard%2C+Mary+H%3BGraubard%2C+Barry+I%3BHollenbeck%2C+Albert+R%3BKilfoy%2C+Briseis+A%3BSchatzkin%2C+Arthur%3BMichaud%2C+Dominique+S%3BCross%2C+Amanda+J&rft.aulast=Ferrucci&rft.aufirst=Leah&rft.date=2010-09-15&rft.volume=116&rft.issue=18&rft.spage=4345&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=10970142&rft_id=info:doi/10.1002%2Fcncr.25463 L2 - http://onlinelibrary.wiley.com/doi/10.1002/cncr.25463/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Meat; Diets; urinary bladder; Nitrates; Nitrites; Urinary bladder; Carcinogenicity; Carcinogenesis; meat; cooking; Amines; Cancer DO - http://dx.doi.org/10.1002/cncr.25463 ER - TY - JOUR T1 - Molecular basis for barbed end uncapping by CARMIL homology domain 3 of mouse CARMIL-1. AN - 753996451; 20630878 AB - Capping protein (CP) is a ubiquitously expressed, 62-kDa heterodimer that binds the barbed end of the actin filament with approximately 0.1 nm affinity to prevent further monomer addition. CARMIL is a multidomain protein, present from protozoa to mammals, that binds CP and is important for normal actin dynamics in vivo. The CARMIL CP binding site resides in its CAH3 domain (CARMIL homology domain 3) located at or near the protein's C terminus. CAH3 binds CP with approximately 1 nm affinity, resulting in a complex with weak capping activity (30-200 nm). Solution assays and single-molecule imaging show that CAH3 binds CP already present on the barbed end, causing a 300-fold increase in the dissociation rate of CP from the end (i.e. uncapping). Here we used nuclear magnetic resonance (NMR) to define the molecular interaction between the minimal CAH3 domain (CAH3a/b) of mouse CARMIL-1 and CP. Specifically, we show that the highly basic CAH3a subdomain is required for the high affinity interaction of CAH3 with a complementary "acidic groove" on CP opposite its actin-binding surface. This CAH3a-CP interaction orients the CAH3b subdomain, which we show is also required for potent anti-CP activity, directly adjacent to the basic patch of CP, shown previously to be required for CP association to and high affinity interaction with the barbed end. The importance of specific residue interactions between CP and CAH3a/b was confirmed by site-directed mutagenesis of both proteins. Together, these results offer a mechanistic explanation for the barbed end uncapping activity of CARMIL, and they identify the basic patch on CP as a crucial regulatory site. JF - The Journal of biological chemistry AU - Zwolak, Adam AU - Uruno, Takehito AU - Piszczek, Grzegorz AU - Hammer, John A AU - Tjandra, Nico AD - Laboratory of Molecular Biophysics, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2010/09/10/ PY - 2010 DA - 2010 Sep 10 SP - 29014 EP - 29026 VL - 285 IS - 37 KW - Actin Capping Proteins KW - 0 KW - Carrier Proteins KW - Lrrc16a protein, mouse KW - Microfilament Proteins KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Animals KW - Mice KW - Protein Structure, Tertiary KW - Protein Binding KW - Surface Properties KW - Protein Structure, Quaternary KW - Actin Capping Proteins -- metabolism KW - Actin Capping Proteins -- genetics KW - Carrier Proteins -- metabolism KW - Carrier Proteins -- chemistry KW - Carrier Proteins -- genetics KW - Actin Capping Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753996451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Molecular+basis+for+barbed+end+uncapping+by+CARMIL+homology+domain+3+of+mouse+CARMIL-1.&rft.au=Zwolak%2C+Adam%3BUruno%2C+Takehito%3BPiszczek%2C+Grzegorz%3BHammer%2C+John+A%3BTjandra%2C+Nico&rft.aulast=Zwolak&rft.aufirst=Adam&rft.date=2010-09-10&rft.volume=285&rft.issue=37&rft.spage=29014&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M110.134221 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-07 N1 - Date created - 2010-09-06 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 2KZ7; PDB N1 - SuppNotes - Cited By: Trends Biochem Sci. 2004 Aug;29(8):418-28 [15362226] Cell. 2004 Aug 6;118(3):363-73 [15294161] J Cell Biol. 1984 Jul;99(1 Pt 1):217-25 [6429155] Nature. 1990 Mar 22;344(6264):352-4 [2179733] J Cell Biol. 1992 Dec;119(5):1151-62 [1447293] J Mol Biol. 1993 Dec 5;234(3):826-36 [8254675] Biochemistry. 1997 Mar 4;36(9):2517-30 [9054557] Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3685-90 [9108038] Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12366-71 [9356455] Nature. 1999 Oct 7;401(6753):613-6 [10524632] Gene. 2004 Dec 22;343(2):291-304 [15588584] Biophys J. 2005 Feb;88(2):1387-402 [15556992] Mol Cell Biol. 2005 May;25(9):3519-34 [15831458] Dev Cell. 2005 Aug;9(2):209-21 [16054028] J Biol Chem. 2006 Apr 14;281(15):10635-50 [16434392] J Biol Chem. 2006 Jul 14;281(28):19196-203 [16707503] J Biol Chem. 2006 Oct 13;281(41):31021-30 [16895918] J Biol Chem. 2006 Nov 24;281(47):36347-59 [16987810] EMBO J. 2006 Nov 29;25(23):5626-33 [17110933] J Mol Biol. 2007 Jan 12;365(2):480-501 [17059832] J Cell Biol. 2006 Dec 18;175(6):947-55 [17178911] J Magn Reson. 2007 Feb;184(2):185-95 [17084097] J Biol Chem. 2007 Feb 23;282(8):5871-9 [17182619] Curr Biol. 2007 Mar 6;17(5):395-406 [17331727] J Biol Chem. 2007 Sep 21;282(38):28014-24 [17656356] J Biomol NMR. 1994 Mar;4(2):301-6 [8019138] J Biomol NMR. 1995 Jan;5(1):67-81 [7881273] Cell. 1995 May 19;81(4):591-600 [7758113] J Biol Chem. 1995 Oct 27;270(43):25316-9 [7592689] Mol Biol Cell. 1996 Jan;7(1):1-15 [8741835] J Cell Biol. 1996 Oct;135(1):169-79 [8858171] Cell. 2008 May 30;133(5):841-51 [18510928] Int Rev Cell Mol Biol. 2008;267:183-206 [18544499] Development. 2009 Apr;136(7):1201-10 [19244282] Protein Expr Purif. 2009 Oct;67(2):113-9 [19427903] Mol Biol Cell. 2009 Dec;20(24):5290-305 [19846667] J Biol Chem. 2010 Jan 22;285(4):2707-20 [19926785] Nat Struct Mol Biol. 2010 Apr;17(4):497-503 [20357771] J Biol Chem. 2010 Aug 13;285(33):25767-81 [20538588] J Biol Chem. 1999 Dec 3;274(49):35159-71 [10574999] Biochemistry. 2000 May 9;39(18):5355-65 [10820006] J Cell Biol. 2001 Jun 25;153(7):1479-97 [11425877] J Magn Reson. 2003 Jan;160(1):65-73 [12565051] J Biol Chem. 2003 Feb 21;278(8):5864-70 [12488317] Cell. 2003 Feb 21;112(4):453-65 [12600310] J Am Chem Soc. 2003 Mar 12;125(10):2902-12 [12617657] EMBO J. 2003 Apr 1;22(7):1529-38 [12660160] J Biol Chem. 2003 Jun 20;278(25):22396-403 [12690097] Curr Biol. 2003 Sep 2;13(17):1531-7 [12956956] J Cell Biol. 2003 Sep 15;162(6):1079-88 [12975351] J Biol Chem. 2004 Jan 23;279(4):3068-77 [14594951] J Cell Biol. 2004 Feb 16;164(4):567-80 [14769858] Eur J Biochem. 1980 Apr;105(2):279-87 [6991253] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M110.134221 ER - TY - JOUR T1 - Simple and flexible classification of gene expression microarrays via Swirls and Ripples AN - 954604105; 14024046 AB - A simple classification rule with few genes and parameters is desirable when applying a classification rule to new data. One popular simple classification rule, diagonal discriminant analysis, yields linear or curved classification boundaries, called Ripples, that are optimal when gene expression levels are normally distributed with the appropriate variance, but may yield poor classification in other situations. A simple modification of diagonal discriminant analysis yields smooth highly nonlinear classification boundaries, called Swirls, that sometimes outperforms Ripples. In particular, if the data are normally distributed with different variances in each class, Swirls substantially outperforms Ripples when using a pooled variance to reduce the number of parameters. The proposed classification rule for two classes selects either Swirls or Ripples after parsimoniously selecting the number of genes and distance measures. Applications to five cancer microarray data sets identified predictive genes related to the tissue organization theory of carcinogenesis. The parsimonious selection of classifiers coupled with the selection of either Swirls or Ripples provides a good basis for formulating a simple, yet flexible, classification rule. Open source software is available for download. JF - BMC Bioinformatics AU - Baker, Stuart G AD - Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, EPN 3131, 6130 Executive Blvd MSC 7354, Bethesda, MD 20892-7354, USA Y1 - 2010/09/08/ PY - 2010 DA - 2010 Sep 08 SP - 452 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 11 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Computer programs KW - software KW - Data processing KW - Carcinogenesis KW - Boundaries KW - Bioinformatics KW - DNA microarrays KW - Cancer KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954604105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Simple+and+flexible+classification+of+gene+expression+microarrays+via+Swirls+and+Ripples&rft.au=Baker%2C+Stuart+G&rft.aulast=Baker&rft.aufirst=Stuart&rft.date=2010-09-08&rft.volume=11&rft.issue=&rft.spage=452&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-11-452 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Gene expression; Computer programs; software; Data processing; Carcinogenesis; Boundaries; Bioinformatics; DNA microarrays; Cancer DO - http://dx.doi.org/10.1186/1471-2105-11-452 ER - TY - JOUR T1 - Historical Review of Occupational Exposures and Cancer Risks in Medical Radiation Workers AN - 856765211; 14037665 AB - Epidemiological studies of medical radiation workers have found excess risks of leukemia, skin and female breast cancer in those employed before 1950 but little consistent evidence of cancer risk increases subsequently. Occupational radiation-related dose-response data and recent and lifetime cancer risk data are limited for radiologists and radiologic technologists and lacking for physicians and technologists performing fluoroscopically guided procedures. Survey data demonstrate that occupational doses to radiologists and radiologic technologists have declined over time. Eighty mostly small studies of cardiologists and fewer studies of other physicians reveal that effective doses to physicians per interventional procedure vary by more than an order of magnitude. For medical radiation workers, there is an urgent need to expand the limited information on average annual, time-trend and organ doses from occupational radiation exposures and to assess lifetime cancer risks of these workers. For physicians and technologists performing interventional procedures, more information about occupational doses should be collected and long-term follow-up studies of cancer and other serious disease risks should be initiated. Such studies will help optimize standardized protocols for radiologic procedures, determine whether current radiation protection measures for medical radiation workers are adequate, provide guidance on cancer screening needs, and yield valuable insights on cancer risks associated with chronic radiation exposure. JF - Radiation Research AU - Linet, Martha S AU - Kim, Kwang Pyo AU - Miller, Donald L AU - Kleinerman, Ruth A AU - Simon, Steven L AU - de Gonzalez, Amy Berrington Y1 - 2010/09/08/ PY - 2010 DA - 2010 Sep 08 SP - 793 EP - 808 PB - Radiation Research Society VL - 174 IS - 6b SN - 0033-7587, 0033-7587 KW - Toxicology Abstracts KW - Breast cancer KW - Occupational exposure KW - X:24390 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856765211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Historical+Review+of+Occupational+Exposures+and+Cancer+Risks+in+Medical+Radiation+Workers&rft.au=Linet%2C+Martha+S%3BKim%2C+Kwang+Pyo%3BMiller%2C+Donald+L%3BKleinerman%2C+Ruth+A%3BSimon%2C+Steven+L%3Bde+Gonzalez%2C+Amy+Berrington&rft.aulast=Linet&rft.aufirst=Martha&rft.date=2010-09-08&rft.volume=174&rft.issue=6b&rft.spage=793&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR2014.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Occupational exposure DO - http://dx.doi.org/10.1667/RR2014.1 ER - TY - JOUR T1 - Protective Role of Interleukin-10 in Ozone-Induced Pulmonary Inflammation AN - 855716469; 14160336 AB - The mechanisms underlying ozone (O3)-induced pulmonary inflammation remain unclear. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is known to inhibit inflammatory mediators. We investigated the molecular mechanisms underlying interleuken-10 (IL-10)-mediated attenuation of O3-induced pulmonary inflammation in mice. Il10-deficient (Il10-/-) and wild-type (Il10+/+) mice were exposed to 0.3 ppm O3 or filtered air for 24, 48, or 72 hr. Immediately after exposure, differential cell counts and total protein (a marker of lung permeability) were assessed from bronchoalveolar lavage fluid (BALF). mRNA and protein levels of cellular mediators were determined from lung homogenates. We also used global mRNA expression analyses of lung tissue with Ingenuity Pathway Analysis to identify patterns of gene expression through which IL-10 modifies O3-induced inflammation. Mean numbers of BALF polymorphonuclear leukocytes (PMNs) were significantly greater in Il10-/- mice than in Il10+/+ mice after exposure to O3 at all time points tested. O3-enhanced nuclear NF- Kappa B translocation was elevated in the lungs of Il10-/- compared with Il10+/+ mice. Gene expression analyses revealed several IL-10-dependent and O3-dependent mediators, including macrophage inflammatory protein 2, cathepsin E, and serum amyloid A3. Results indicate that IL-10 protects against O3-induced pulmonary neutrophilic inflammation and cell proliferation. Moreover, gene expression analyses identified three response pathways and several genetic targets through which IL-10 may modulate the innate and adaptive immune response. These novel mechanisms of protection against the pathogenesis of O3-induced pulmonary inflammation may also provide potential therapeutic targets to protect susceptible individuals. JF - Environmental Health Perspectives AU - Backus, Gillian S AU - Howden, Reuben AU - Fostel, Jennifer AU - Bauer, Alison K AU - Cho, Hye-Youn AU - Marzec, Jacqui AU - Peden, David B AU - Kleeberger, Steven R AD - National Institute of Environmental Health Sciences, Laboratory of Respiratory Biology, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2010/09/08/ PY - 2010 DA - 2010 Sep 08 SP - 1721 EP - 1727 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 118 IS - 2 SN - 0091-6765, 0091-6765 KW - Immunology Abstracts; Environment Abstracts KW - air pollution KW - gene array KW - IL-10 KW - inflammation KW - lung KW - ozone KW - pulmonary KW - Molecular modelling KW - Leukocytes (polymorphonuclear) KW - Interleukin 1 KW - Interleukin 10 KW - NF- Kappa B protein KW - Gene expression KW - Permeability KW - Nuclear transport KW - Bronchus KW - Ozone KW - macrophage inflammatory protein 2 KW - Leukocytes (neutrophilic) KW - Mice KW - Alveoli KW - Inflammation KW - Cathepsin E KW - Lung KW - Proteins KW - translocation KW - Immune response KW - Cell proliferation KW - Amyloid KW - F 06935:Development, Aging & Organ Systems KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855716469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Protective+Role+of+Interleukin-10+in+Ozone-Induced+Pulmonary+Inflammation&rft.au=Backus%2C+Gillian+S%3BHowden%2C+Reuben%3BFostel%2C+Jennifer%3BBauer%2C+Alison+K%3BCho%2C+Hye-Youn%3BMarzec%2C+Jacqui%3BPeden%2C+David+B%3BKleeberger%2C+Steven+R&rft.aulast=Backus&rft.aufirst=Gillian&rft.date=2010-09-08&rft.volume=118&rft.issue=2&rft.spage=1721&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002182 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Molecular modelling; macrophage inflammatory protein 2; Leukocytes (polymorphonuclear); Interleukin 1; Leukocytes (neutrophilic); Interleukin 10; Alveoli; Inflammation; NF- Kappa B protein; Gene expression; Nuclear transport; Permeability; Bronchus; Cathepsin E; Lung; Immune response; Cell proliferation; Ozone; Amyloid; Proteins; Mice; translocation DO - http://dx.doi.org/10.1289/ehp.1002182 ER - TY - JOUR T1 - Cigarette Smoking and Adenocarcinomas of the Esophagus and Esophagogastric Junction: A Pooled Analysis From the International BEACON Consortium AN - 759316559; 13721190 AB - BACKGROUND: Previous studies that showed an association between smoking and adenocarcinomas of the esophagus and esophagogastric junction were limited in their ability to assess differences by tumor site, sex, dose-response, and duration of cigarette smoking cessation. METHODS: We used primary data from 10 population-based case-control studies and two cohort studies from the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium. Analyses were restricted to white non-Hispanic men and women. Patients were classified as having esophageal adenocarcinoma (n = 1540), esophagogastric junctional adenocarcinoma (n = 1450), or a combination of both (all adenocarcinoma; n = 2990). Control subjects (n = 9453) were population based. Associations between pack-years of cigarette smoking and risks of adenocarcinomas were assessed, as well as their potential modification by sex and duration of smoking cessation. Study-specific odds ratios (ORs) estimated using multivariable logistic regression models, adjusted for age, sex, body mass index, education, and gastroesophageal reflux, were pooled using a meta-analytic methodology to generate summary odds ratios. All statistical tests were two-sided. RESULTS: The summary odds ratios demonstrated strong associations between cigarette smoking and esophageal adenocarcinoma (OR = 1.96, 95% confidence interval [CI] = 1.64 to 2.34), esophagogastric junctional adenocarcinoma (OR = 2.18, 95% CI = 1.84 to 2.58), and all adenocarcinoma (OR = 2.08, 95% CI = 1.83 to 2.37). In addition, there was a strong dose-response association between pack-years of cigarette smoking and each outcome (P < .001). Compared with current smokers, longer smoking cessation was associated with a decreased risk of all adenocarcinoma after adjusting for pack-years (<10 years of smoking cessation: OR = 0.82, 95% CI = 0.60 to 1.13; and .10 years of smoking cessation: OR = 0.71, 95% CI = 0.56 to 0.89). Sex-specific summary odds ratios were similar. CONCLUSIONS: Cigarette smoking is associated with increased risks of adenocarcinomas of the esophagus and esophagogastric junction in white men and women; compared with current smoking, smoking cessation was associated with reduced risks. JF - Journal of the National Cancer Institute AU - Cook, Michael B AU - Kamangar, Farin AU - Whiteman, David C AU - Freedman, Neal D AU - Gammon, Marilie D AU - Bernstein, Leslie AU - Brown, Linda M AU - Risch, Harvey A AU - Ye, Weimin AU - Sharp, Linda AU - Pandeya, Nirmala AU - Webb, Penelope M AU - Wu, Anna H AU - Ward, Mary H AU - Giffen, Carol AU - Casson, Alan G AU - Abnet, Christian C AU - Murray, Liam J AU - Corley, Douglas A AU - Nyren, Olof AU - Vaughan, Thomas L AU - Chow, Wong-Ho AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (MBC, FK, NDF, MHW, CCA, W-HC) Y1 - 2010/09/08/ PY - 2010 DA - 2010 Sep 08 SP - 1344 EP - 1353 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 17 SN - 0027-8874, 0027-8874 KW - Toxicology Abstracts; Risk Abstracts KW - Age KW - Cigarettes KW - Statistical analysis KW - tumors KW - Models KW - risk reduction KW - Smoking KW - body mass KW - Dose-response effects KW - Cigarette smoking KW - Regression analysis KW - Drug addiction KW - Sex KW - Esophagus KW - Data processing KW - Barrett's esophagus KW - Tumors KW - Cancer KW - Education KW - Gastroesophageal reflux KW - Body mass index KW - Adenocarcinoma KW - X 24380:Social Poisons & Drug Abuse KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759316559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Cigarette+Smoking+and+Adenocarcinomas+of+the+Esophagus+and+Esophagogastric+Junction%3A+A+Pooled+Analysis+From+the+International+BEACON+Consortium&rft.au=Cook%2C+Michael+B%3BKamangar%2C+Farin%3BWhiteman%2C+David+C%3BFreedman%2C+Neal+D%3BGammon%2C+Marilie+D%3BBernstein%2C+Leslie%3BBrown%2C+Linda+M%3BRisch%2C+Harvey+A%3BYe%2C+Weimin%3BSharp%2C+Linda%3BPandeya%2C+Nirmala%3BWebb%2C+Penelope+M%3BWu%2C+Anna+H%3BWard%2C+Mary+H%3BGiffen%2C+Carol%3BCasson%2C+Alan+G%3BAbnet%2C+Christian+C%3BMurray%2C+Liam+J%3BCorley%2C+Douglas+A%3BNyren%2C+Olof%3BVaughan%2C+Thomas+L%3BChow%2C+Wong-Ho&rft.aulast=Cook&rft.aufirst=Michael&rft.date=2010-09-08&rft.volume=102&rft.issue=17&rft.spage=1344&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Esophagus; Data processing; Barrett's esophagus; Statistical analysis; Tumors; Models; Smoking; Gastroesophageal reflux; Cigarette smoking; Regression analysis; Adenocarcinoma; Drug addiction; Body mass index; Sex; risk reduction; Age; Education; Cigarettes; body mass; Dose-response effects; tumors; Cancer ER - TY - JOUR T1 - Association of Meat and Fat Intake With Liver Disease and Hepatocellular Carcinoma in the NIH-AARP Cohort AN - 759316492; 13721189 AB - BACKGROUND: Several plausible mechanisms, including fat, iron, heterocyclic amines, and N-nitroso compounds, link meat intake with chronic liver disease (CLD) and hepatocellular carcinoma (HCC). Few studies have investigated these associations. METHODS: We prospectively examined the relationship between meat and associated exposures with CLD mortality (n = 551; not including HCC) and HCC incidence (n = 338) in 495 006 men and women of the National Institutes of Health-AARP Diet and Health Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the fifth (Q5) vs the first (Q1) quintile were estimated from multivariable adjusted Cox proportional hazards regression models. All tests of statistical significance were two-sided. RESULTS: We found inverse associations between white meat and risk of CLD (HR = 0.52, 95% CI = 0.39 to 0.70, 7.5 vs 18.2 cases per 100 000 person-years) and HCC (HR = 0.52, 95% CI = 0.36 to 0.77, 5.8 vs 14.3 cases per 100 000 person-years). Red meat was associated with higher risk of CLD (HR = 2.59, 95% CI = 1.86 to 3.61, 22.3 vs 6.2 cases per 100 000 person-years) and HCC (HR = 1.74, 95% CI = 1.16 to 2.61, 14.9 vs 5.7 cases per 100 000 person-years). Among fat types, results were strongest for saturated fat (for CLD, HR = 3.50, 95% CI = 2.48 to 4.96, 23.0 vs 6.5 cases per 100 000 person-years; for HCC, HR = 1.87, 95% CI = 1.23 to 2.85, 14.5 vs 6.3 cases per 100 000 person-years). After mutual adjustment, risk estimates persisted for saturated fat, red meat, and white meat. Heme iron, processed meat, nitrate, and nitrite were positively associated with CLD but not with HCC. Individual heterocyclic amines, 2-amino-3,4,8-trimethylimidazo[4,5,-f]quinoxaline (DiMeIQx), 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx), and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP), were not associated with either outcome. CONCLUSION: Our results suggest that red meat and saturated fat may be associated with increased CLD and HCC risk, whereas white meat may be associated with reduced risk. JF - Journal of the National Cancer Institute AU - Freedman, Neal D AU - Cross, Amanda J AU - McGlynn, Katherine A AU - Abnet, Christian C AU - Park, Yikyung AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Everhart, James E AU - Sinha, Rashmi AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD (NDF, AJC, KAM, CCA, YP, AS, RS) Y1 - 2010/09/08/ PY - 2010 DA - 2010 Sep 08 SP - 1354 EP - 1365 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 17 SN - 0027-8874, 0027-8874 KW - Toxicology Abstracts; Risk Abstracts KW - Heterocyclic amines KW - Nitrate KW - Heme KW - Statistical analysis KW - Models KW - Risk factors KW - meat KW - Regression analysis KW - Nitrite KW - Hepatocellular carcinoma KW - Diets KW - Mortality KW - Liver diseases KW - Nitrates KW - Amines KW - Cancer KW - Meat KW - N-Nitroso compounds KW - Nitrites KW - Liver KW - quinoxaline KW - Iron KW - X 24320:Food Additives & Contaminants KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759316492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Association+of+Meat+and+Fat+Intake+With+Liver+Disease+and+Hepatocellular+Carcinoma+in+the+NIH-AARP+Cohort&rft.au=Freedman%2C+Neal+D%3BCross%2C+Amanda+J%3BMcGlynn%2C+Katherine+A%3BAbnet%2C+Christian+C%3BPark%2C+Yikyung%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur%3BEverhart%2C+James+E%3BSinha%2C+Rashmi&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2010-09-08&rft.volume=102&rft.issue=17&rft.spage=1354&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diets; Nitrate; Heterocyclic amines; Mortality; Liver diseases; Heme; Statistical analysis; Models; Meat; N-Nitroso compounds; Risk factors; quinoxaline; Regression analysis; Nitrite; Iron; Hepatocellular carcinoma; Nitrates; Nitrites; meat; Liver; Amines; Cancer ER - TY - JOUR T1 - Stability of the Neurotensin Receptor NTS1 Free in Detergent Solution and Immobilized to Affinity Resin AN - 954581383; 13748883 AB - Purification of recombinant membrane receptors is commonly achieved by use of an affinity tag followed by an additional chromatography step if required. This second step may exploit specific receptor properties such as ligand binding. However, the effects of multiple purification steps on protein yield and integrity are often poorly documented. We have previously reported a robust two-step purification procedure for the recombinant rat neurotensin receptor NTS1 to give milligram quantities of functional receptor protein. First, histidine-tagged receptors are enriched by immobilized metal affinity chromatography using Ni-NTA resin. Second, remaining contaminants in the Ni-NTA column eluate are removed by use of a subsequent neurotensin column yielding pure NTS1. Whilst the neurotensin column eluate contained functional receptor protein, we observed in the neurotensin column flow-through misfolded NTS1. To investigate the origin of the misfolded receptors, we estimated the amount of functional and misfolded NTS1 at each purification step by radio-ligand binding, densitometry of Coomassie stained SDS-gels, and protein content determination. First, we observed that correctly folded NTS1 suffers damage by exposure to detergent and various buffer compositions as seen by the loss of [3H]neurotensin binding over time. Second, exposure to the neurotensin affinity resin generated additional misfolded receptor protein. Our data point towards two ways by which misfolded NTS1 may be generated: Damage by exposure to buffer components and by close contact of the receptor to the neurotensin affinity resin. Because NTS1 in detergent solution is stabilized by neurotensin, we speculate that the occurrence of aggregated receptor after contact with the neurotensin resin is the consequence of perturbations in the detergent belt surrounding the NTS1 transmembrane core. Both effects reduce the yield of functional receptor protein. JF - PLoS ONE AU - White, Jim F AU - Grisshammer, Reinhard AD - National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America Y1 - 2010/09/07/ PY - 2010 DA - 2010 Sep 07 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 5 IS - 9 KW - Toxicology Abstracts KW - Affinity chromatography KW - Neurotensin KW - X 24340:Cosmetics, Toiletries & Household Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954581383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Stability+of+the+Neurotensin+Receptor+NTS1+Free+in+Detergent+Solution+and+Immobilized+to+Affinity+Resin&rft.au=White%2C+Jim+F%3BGrisshammer%2C+Reinhard&rft.aulast=White&rft.aufirst=Jim&rft.date=2010-09-07&rft.volume=5&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0012579 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-03-24 N1 - SubjectsTermNotLitGenreText - Neurotensin DO - http://dx.doi.org/10.1371/journal.pone.0012579 ER - TY - JOUR T1 - Non-malignant Thyroid Diseases after a Wide Range of Radiation Exposures AN - 879469781; 14037662 AB - The thyroid gland is one of the most radiosensitive human organs. While it is well known that radiation exposure increases the risk of thyroid cancer, less is known about its effects in relation to non-malignant thyroid diseases. The aim of this review is to evaluate the effects of high- and low-dose radiation on benign structural and functional diseases of the thyroid. We examined the results of major studies from cancer patients treated with high-dose radiotherapy or thyrotoxicosis patients treated with high doses of iodine-131, patients treated with moderate- to high-dose radiotherapy for benign diseases, persons exposed to low doses from environmental radiation, and survivors of the atomic bombings who were exposed to a range of doses. We evaluated radiation effects on structural (tumors, nodules), functional (hyper- and hypothyroidism), and autoimmune thyroid diseases. After a wide range of doses of ionizing radiation, an increased risk of thyroid adenomas and nodules was observed in a variety of populations and settings. The dose response appeared to be linear at low to moderate doses, but in one study there was some suggestion of a reduction in risk above 5Gy. The elevated risk for benign tumors continues for decades after exposure. Considerably less consistent findings are available regarding functional thyroid diseases including autoimmune diseases. In general, associations for these outcomes were fairly weak, and significant radiation effects were most often observed after high doses, particularly for hypothyroidism. A significant radiation dose-response relationship was demonstrated for benign nodules and follicular adenomas. The effects of radiation on functional thyroid diseases are less clear, partly due to the greater difficulties encountered in studying these diseases. JF - Radiation Research AU - Ron, Elaine AU - Brenner, Alina AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 Y1 - 2010/09/07/ PY - 2010 DA - 2010 Sep 07 SP - 877 EP - 888 PB - Radiation Research Society VL - 174 IS - 6b SN - 0033-7587, 0033-7587 KW - Toxicology Abstracts KW - Adenoma KW - thyroid diseases KW - X:24390 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879469781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Non-malignant+Thyroid+Diseases+after+a+Wide+Range+of+Radiation+Exposures&rft.au=Ron%2C+Elaine%3BBrenner%2C+Alina&rft.aulast=Ron&rft.aufirst=Elaine&rft.date=2010-09-07&rft.volume=174&rft.issue=6b&rft.spage=877&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR1953.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - thyroid diseases DO - http://dx.doi.org/10.1667/RR1953.1 ER - TY - JOUR T1 - Small-Molecule Antioxidant Proteome-Shields in Deinococcus radiodurans AN - 807266228; 13748869 AB - For Deinococcus radiodurans and other bacteria which are extremely resistant to ionizing radiation, ultraviolet radiation, and desiccation, a mechanistic link exists between resistance, manganese accumulation, and protein protection. We show that ultrafiltered, protein-free preparations of D. radiodurans cell extracts prevent protein oxidation at massive doses of ionizing radiation. In contrast, ultrafiltrates from ionizing radiation-sensitive bacteria were not protective. The D. radiodurans ultrafiltrate was enriched in Mn, phosphate, nucleosides and bases, and peptides. When reconstituted in vitro at concentrations approximating those in the D. radiodurans cytosol, peptides interacted synergistically with Mn2+ and orthophosphate, and preserved the activity of large, multimeric enzymes exposed to 50,000 Gy, conditions which obliterated DNA. When applied ex vivo, the D. radiodurans ultrafiltrate protected Escherichia coli cells and human Jurkat T cells from extreme cellular insults caused by ionizing radiation. By establishing that Mn2+-metabolite complexes of D. radiodurans specifically protect proteins against indirect damage caused by gamma-rays delivered in vast doses, our findings provide the basis for a new approach to radioprotection and insight into how surplus Mn budgets in cells combat reactive oxygen species. JF - PLoS ONE AU - Daly, Michael J AU - Gaidamakova, Elena K AU - Matrosova, Vera Y AU - Kiang, Juliann G AU - Fukumoto, Risaku AU - Lee, Duck-Yeon AU - Wehr, Nancy B AU - Viteri, Gabriela A AU - Berlett, Barbara S AU - Levine, Rodney L AD - Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2010/09/03/ PY - 2010 DA - 2010 Sep 03 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 5 IS - 9 KW - Microbiology Abstracts B: Bacteriology KW - Antioxidants KW - Enzymes KW - U.V. radiation KW - Reactive oxygen species KW - Phosphate KW - Ionizing radiation KW - nucleosides KW - Radioprotection KW - Oxidation KW - Escherichia coli KW - Lymphocytes T KW - DNA KW - Cytosol KW - Desiccation KW - Deinococcus radiodurans KW - orthophosphate KW - Manganese KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807266228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Small-Molecule+Antioxidant+Proteome-Shields+in+Deinococcus+radiodurans&rft.au=Daly%2C+Michael+J%3BGaidamakova%2C+Elena+K%3BMatrosova%2C+Vera+Y%3BKiang%2C+Juliann+G%3BFukumoto%2C+Risaku%3BLee%2C+Duck-Yeon%3BWehr%2C+Nancy+B%3BViteri%2C+Gabriela+A%3BBerlett%2C+Barbara+S%3BLevine%2C+Rodney+L&rft.aulast=Daly&rft.aufirst=Michael&rft.date=2010-09-03&rft.volume=5&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0012570 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Antioxidants; Enzymes; U.V. radiation; Phosphate; Reactive oxygen species; Ionizing radiation; Oxidation; Radioprotection; nucleosides; Cytosol; DNA; Lymphocytes T; Desiccation; orthophosphate; Manganese; Escherichia coli; Deinococcus radiodurans DO - http://dx.doi.org/10.1371/journal.pone.0012570 ER - TY - JOUR T1 - Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1. AN - 749009032; 20573957 AB - Glutamate, the major excitatory neurotransmitter in the brain, activates receptors coupled to membrane depolarization and Ca(2+) influx that mediates functional responses of neurons including processes such as learning and memory. Here we show that reversible nuclear oxidative DNA damage occurs in cerebral cortical neurons in response to transient glutamate receptor activation using non-toxic physiological levels of glutamate. This DNA damage was prevented by intracellular Ca(2+) chelation, the mitochondrial superoxide dismutase mimetic MnTMPyP (Mn-5,10,15,20-tetra(4-pyridyl)-21H,23H-porphine chloride tetrakis(methochloride)), and blockade of the permeability transition pore. The repair of glutamate-induced DNA damage was associated with increased DNA repair activity and increased mRNA and protein levels of apurinic endonuclease 1 (APE1). APE1 knockdown induced accumulation of oxidative DNA damage after glutamate treatment, suggesting that APE1 is a key repair protein for glutamate-induced DNA damage. A cAMP-response element-binding protein (CREB) binding sequence is present in the Ape1 gene (encodes APE1 protein) promoter and treatment of neurons with a Ca(2+)/calmodulin-dependent kinase inhibitor (KN-93) blocked the ability of glutamate to induce CREB phosphorylation and APE1 expression. Selective depletion of CREB using RNA interference prevented glutamate-induced up-regulation of APE1. Thus, glutamate receptor stimulation triggers Ca(2+)- and mitochondrial reactive oxygen species-mediated DNA damage that is then rapidly repaired by a mechanism involving Ca(2+)-induced, CREB-mediated APE1 expression. Our findings reveal a previously unknown ability of neurons to efficiently repair oxidative DNA lesions after transient activation of glutamate receptors. JF - The Journal of biological chemistry AU - Yang, Jenq-Lin AU - Tadokoro, Takashi AU - Keijzers, Guido AU - Mattson, Mark P AU - Bohr, Vilhelm A AD - Laboratory of Molecular Gerontology, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA. Y1 - 2010/09/03/ PY - 2010 DA - 2010 Sep 03 SP - 28191 EP - 28199 VL - 285 IS - 36 KW - Cyclic AMP Response Element-Binding Protein KW - 0 KW - Receptors, Glutamate KW - Superoxides KW - 11062-77-4 KW - Glutamic Acid KW - 3KX376GY7L KW - Calcium-Calmodulin-Dependent Protein Kinases KW - EC 2.7.11.17 KW - DNA-(Apurinic or Apyrimidinic Site) Lyase KW - EC 4.2.99.18 KW - Index Medicus KW - Rats KW - Cerebral Cortex -- cytology KW - Calcium-Calmodulin-Dependent Protein Kinases -- metabolism KW - Animals KW - Superoxides -- metabolism KW - Rats, Sprague-Dawley KW - Gene Expression Regulation, Enzymologic KW - DNA Damage KW - Mitochondria -- drug effects KW - Receptors, Glutamate -- metabolism KW - Mitochondria -- metabolism KW - DNA Repair -- genetics KW - DNA-(Apurinic or Apyrimidinic Site) Lyase -- genetics KW - Cyclic AMP Response Element-Binding Protein -- metabolism KW - Neurons -- metabolism KW - Oxidative Stress -- drug effects KW - Neurons -- enzymology KW - Oxidative Stress -- genetics KW - Up-Regulation KW - Glutamic Acid -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/749009032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Neurons+efficiently+repair+glutamate-induced+oxidative+DNA+damage+by+a+process+involving+CREB-mediated+up-regulation+of+apurinic+endonuclease+1.&rft.au=Yang%2C+Jenq-Lin%3BTadokoro%2C+Takashi%3BKeijzers%2C+Guido%3BMattson%2C+Mark+P%3BBohr%2C+Vilhelm+A&rft.aulast=Yang&rft.aufirst=Jenq-Lin&rft.date=2010-09-03&rft.volume=285&rft.issue=36&rft.spage=28191&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M109.082883 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-05 N1 - Date created - 2010-08-30 N1 - 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Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M109.082883 ER - TY - JOUR T1 - Malaria: The gorilla connection AN - 1468361356; 13761292 AB - ABSTRACT NOT AVAILABLE. JF - Nature AU - Holmes, Edward C AD - Edward C. Holmes is at the Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA, and the Fogarty International Center, National Institutes of Health, Bethesda, Maryland. echolmes[AT]psu.edu PY - 2010 SP - 404 EP - 405 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 467 IS - 7314 SN - 0028-0836, 0028-0836 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Human diseases KW - Malaria KW - K 03410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1468361356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Malaria%3A+The+gorilla+connection&rft.au=Holmes%2C+Edward+C&rft.aulast=Holmes&rft.aufirst=Edward&rft.date=2010-09-03&rft.volume=467&rft.issue=7314&rft.spage=404&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2F467404a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-12-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Human diseases; Malaria DO - http://dx.doi.org/10.1038/467404a ER - TY - JOUR T1 - miR-23b targets proline oxidase, a novel tumor suppressor protein in renal cancer. AN - 754002172; 20562915 AB - Proline oxidase (POX) is a novel mitochondrial tumor suppressor that can suppress proliferation and induce apoptosis through the generation of reactive oxygen species (ROS) and decreasing hypoxia-inducible factor (HIF) signaling. Recent studies have shown the absence of expression of POX in human cancer tissues, including renal cancer. However, the mechanism for the loss of POX remains obscure. No genetic or epigenetic variation of POX gene was found. In this study, we identified the upregulated miR-23b in renal cancer as an important regulator of POX. Ectopic overexpression of miR-23b in normal renal cells resulted in striking downregulation of POX, whereas POX expression increased markedly when endogenous miR-23b was knocked down by its antagomirs in renal cancer cells. Consistent with the POX-mediated tumor suppression pathway, these antagomirs induced ROS, inhibited HIF signaling and increased apoptosis. Furthermore, we confirmed the regulation of miR-23b on POX and its function in the DLD1 Tet-off POX cell system. Using a luciferase reporter system, we verified the direct binding of miR-23b to the POX mRNA 3'-untranslated region. In addition, pairs of human renal carcinoma and normal tissues showed a negative correlation between miR-23b and POX protein expression, providing its clinical corroboration. Taken together, our results suggested that miR-23b, by targeting POX, could function as an oncogene; decreasing miR-23b expression may prove to be an effective way of inhibiting kidney tumor growth. JF - Oncogene AU - Liu, W AU - Zabirnyk, O AU - Wang, H AU - Shiao, Y-H AU - Nickerson, M L AU - Khalil, S AU - Anderson, L M AU - Perantoni, A O AU - Phang, J M AD - Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA. liuwei3@mail.nih.gov Y1 - 2010/09/02/ PY - 2010 DA - 2010 Sep 02 SP - 4914 EP - 4924 VL - 29 IS - 35 KW - 3' Untranslated Regions KW - 0 KW - MIRN23 microRNA, human KW - MicroRNAs KW - RNA, Messenger KW - Tumor Suppressor Proteins KW - Proline Oxidase KW - EC 1.5.3.- KW - Index Medicus KW - Base Sequence KW - Down-Regulation -- genetics KW - Humans KW - Cell Line, Tumor KW - RNA, Messenger -- genetics KW - Cell Proliferation KW - 3' Untranslated Regions -- genetics KW - Gene Expression Regulation, Neoplastic -- genetics KW - Kidney Neoplasms -- genetics KW - Kidney Neoplasms -- pathology KW - MicroRNAs -- genetics KW - Kidney Neoplasms -- enzymology KW - Tumor Suppressor Proteins -- metabolism KW - Tumor Suppressor Proteins -- genetics KW - Proline Oxidase -- metabolism KW - Proline Oxidase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754002172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=miR-23b+targets+proline+oxidase%2C+a+novel+tumor+suppressor+protein+in+renal+cancer.&rft.au=Liu%2C+W%3BZabirnyk%2C+O%3BWang%2C+H%3BShiao%2C+Y-H%3BNickerson%2C+M+L%3BKhalil%2C+S%3BAnderson%2C+L+M%3BPerantoni%2C+A+O%3BPhang%2C+J+M&rft.aulast=Liu&rft.aufirst=W&rft.date=2010-09-02&rft.volume=29&rft.issue=35&rft.spage=4914&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2010.237 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-04 N1 - Date created - 2010-09-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/onc.2010.237 ER - TY - JOUR T1 - Should symptom frequency be factored into scalar measures of alcohol use disorder severity? AN - 920067593; 4266307 AB - Aim: To evaluate whether weighting counts of alcohol use disorder (AUD) criteria or symptoms by their frequency of occurrence improves their association with correlates of AUD. Design and participants: with a representative sample of US adults interviewed in 1991-92. Analyses were conducted among past-year drinkers (12+ drinks, n = 18 352) and individuals with past-year DSM-IV AUD (n = 2770). Measurements: Thirty-one symptom item indicators, whose frequency of occurrence was measured in eight categories, were used to create unweighted and frequency-weighted counts of DSM-IV past-year AUD symptoms and criteria. Correlates included density of familial alcoholism and past-year volume of ethanol intake, frequency of intoxication and utilization of alcohol treatment. Findings strongly and positively with the frequency of AUD symptom occurrence, weighting for symptom frequency did not strengthen their association consistently with AUD severity scores. Improved performance of the weighted scores was observed primarily among AUD correlates linked closely with the frequency of heavy drinking and among individuals with AUD. Criterion counts were correlated nearly as strongly as symptom counts with the AUD correlates. Conclusions: Frequency weighting may add somewhat to the validity of AUD severity measures, especially those that are intended for use among individuals with AUD, e.g. in clinical settings. For studying the etiology and course of AUD in the general population, an equally effective and less time-consuming alternative to obtaining symptom frequency may be the use of unweighted criterion counts accompanied by independent measures of frequency of heavy drinking. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Grant, Bridget F AU - Dawson, Deborah A AD - National Institutes of Health, Bethesda Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1568 EP - 1579 VL - 105 IS - 9 SN - 0965-2140, 0965-2140 KW - Sociology KW - Alcohol KW - Etiology KW - Alcoholic beverages KW - Alcoholism KW - Validity KW - Interviews KW - Addiction KW - U.S.A. KW - Drinkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920067593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Should+symptom+frequency+be+factored+into+scalar+measures+of+alcohol+use+disorder+severity%3F&rft.au=Grant%2C+Bridget+F%3BDawson%2C+Deborah+A&rft.aulast=Grant&rft.aufirst=Bridget&rft.date=2010-09-01&rft.volume=105&rft.issue=9&rft.spage=1568&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2010.02994.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 13230 2688 2449 10404; 3736; 912 1564 5114; 909; 4491 2086 4641 3617 6220; 913 561 6220; 561 6220; 6832 10919; 433 293 14 DO - http://dx.doi.org/10.1111/j.1360-0443.2010.02994.x ER - TY - JOUR T1 - US state alcohol sales compared to survey data, 1993-2006 AN - 920054000; 4266309 AB - Assess long-term trends of the correlation between alcohol sales data and survey data. Design: alcohol consumption data from the US Alcohol Epidemiologic Data System based on sales, tax receipts or alcohol shipments. Cross-sectional, state annual estimates of alcohol-related measures for adults from the US Behavioral Risk Factor Surveillance System using telephone surveys. Setting: United States. Participants: industry (sales data) and randomly selected adults aged . 18 years 1993-2006 (survey data). Measurements: State-level per capita annual alcohol consumption estimates from sales data. Self-reported alcohol consumption, current drinking, heavy drinking, binge drinking and alcohol-impaired driving from surveys. Correlation coefficients were calculated using linear regression models. Findings accounted for a median of 22% to 32% of state sales data across years. Nevertheless, state consumption estimates from both sources were strongly correlated with annual r-values ranging from 0.55-0.71. State sales data had moderate-to-strong correlations with survey estimates of current drinking, heavy drinking and binge drinking (range of r-values across years: 0.57-0.65; 0.33-0.70 and 0.45-0.61, respectively), but a weaker correlation with alcohol-impaired driving (range of r-values: 0.24-0.56). There were no trends in the magnitude of correlation coefficients. Conclusions: Although state surveys substantially underestimated alcohol consumption, the consistency of the strength of the association between sales consumption and survey data for most alcohol measures suggest both data sources continue to provide valuable information. These findings support and extend the distribution of consumption model and single distribution theory, suggesting that both sales and survey data are useful for monitoring population changes in alcohol use. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Roeber, James AU - Nelson, David E AU - Naimi, Timothy S AU - Brewer, Robert D AD - National Cancer Institute, Bethesda ; Centers for Disease Control and Prevention, Atlanta ; New Mexico Department of Health, Albuquerque Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1589 EP - 1596 VL - 105 IS - 9 SN - 0965-2140, 0965-2140 KW - Sociology KW - Comparative analysis KW - Sales KW - Alcoholic beverages KW - Statistics KW - Surveys KW - Cross-sectional analysis KW - Estimation KW - U.S.A. KW - State KW - Alcoholism KW - Consumption KW - 20th century UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920054000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=US+state+alcohol+sales+compared+to+survey+data%2C+1993-2006&rft.au=Roeber%2C+James%3BNelson%2C+David+E%3BNaimi%2C+Timothy+S%3BBrewer%2C+Robert+D&rft.aulast=Roeber&rft.aufirst=James&rft.date=2010-09-01&rft.volume=105&rft.issue=9&rft.spage=1589&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2010.03007.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 913 561 6220; 12233; 11239; 2630 971; 12429; 476 8168 5889; 12168 9008 12092 9720 6590; 912 1564 5114; 2805 3872 554 971; 4403 7854; 3063 971; 433 293 14 DO - http://dx.doi.org/10.1111/j.1360-0443.2010.03007.x ER - TY - JOUR T1 - A custom 148 gene-based resequencing chip and the SNP explorer software: new tools to study antibody deficiency AN - 888106189; 15051099 AB - Hyper-IgM syndrome and Common Variable Immunodeficiency are heterogeneous disorders characterized by a predisposition to serious infection and impaired or absent neutralizing antibody responses. Although a number of single gene defects have been associated with these immune deficiency disorders, the genetic basis of many cases is not known. To facilitate mutation screening in patients with these syndromes, we have developed a custom 300-kb resequencing array, the Hyper-IgM/CVID chip, which interrogates 1,576 coding exons and intron-exon junction regions from 148 genes implicated in B-cell development and immunoglobulin isotype switching. Genomic DNAs extracted from patients were hybridized to the array using a high-throughput protocol for target sequence amplification, pooling, and hybridization. A Web-based application, SNP Explorer, was developed to directly analyze and visualize the single nucleotide polymorphism (SNP) annotation and for quality filtering. Several mutations in known disease-susceptibility genes such as CD40LG, TNFRSF13B, IKBKG, AICDA, as well as rare nucleotide changes in other genes such as TRAF3IP2, were identified in patient DNA samples and validated by direct sequencing. We conclude that the Hyper-IgM/CVID chip combined with SNP Explorer may provide a cost-effective tool for high-throughput discovery of novel mutations among hundreds of disease-relevant genes in patients with inherited antibody deficiency. Hum Mutat 31:1080-1088, 2010. Published 2010 Wiley-Liss, Inc. JF - Human Mutation AU - Wang, Hong-Ying AU - Gopalan, Vivek AU - Aksentijevich, Ivona AU - Yeager, Meredith AU - Ma, Chi Adrian AU - Mohamoud, Yasmin Ali AU - Quinones, Mariam AU - Matthews, Casey AU - Boland, Joseph AU - Niemela, Julie E AU - Torgerson, Troy R AU - Giliani, Silvia AU - Uzel, Gulbu AU - Orange, Jordan S AU - Shapiro, Ralph AU - Notarangelo, Luigi AU - Ochs, Hans D AU - Fleisher, Thomas AU - Kastner, Daniel AU - Chanock, Stephen J AU - Jain, Ashish AD - Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, AJain@niaid.nih.gov AJain@niaid.nih.gov AJain@niaid.nih.gov AJain@niaid.nih.gov AJain@niaid.nih.gov AJain@niaid.nih.gov AJain@niaid.nih.gov AJain@niaid.nih.gov AJain@niaid.nih.gov AJain@niaid.nih.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1080 EP - 1088 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 31 IS - 9 SN - 1098-1004, 1098-1004 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Common variable immunodeficiency KW - Computer programs KW - DNA KW - DNA sequencing KW - Development KW - Exons KW - Immunoglobulins KW - Infection KW - Job's syndrome KW - Lymphocytes B KW - Mutation KW - Nucleotide sequence KW - Single-nucleotide polymorphism KW - genomics KW - software KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888106189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Mutation&rft.atitle=A+custom+148+gene-based+resequencing+chip+and+the+SNP+explorer+software%3A+new+tools+to+study+antibody+deficiency&rft.au=Wang%2C+Hong-Ying%3BGopalan%2C+Vivek%3BAksentijevich%2C+Ivona%3BYeager%2C+Meredith%3BMa%2C+Chi+Adrian%3BMohamoud%2C+Yasmin+Ali%3BQuinones%2C+Mariam%3BMatthews%2C+Casey%3BBoland%2C+Joseph%3BNiemela%2C+Julie+E%3BTorgerson%2C+Troy+R%3BGiliani%2C+Silvia%3BUzel%2C+Gulbu%3BOrange%2C+Jordan+S%3BShapiro%2C+Ralph%3BNotarangelo%2C+Luigi%3BOchs%2C+Hans+D%3BFleisher%2C+Thomas%3BKastner%2C+Daniel%3BChanock%2C+Stephen+J%3BJain%2C+Ashish&rft.aulast=Wang&rft.aufirst=Hong-Ying&rft.date=2010-09-01&rft.volume=31&rft.issue=9&rft.spage=1080&rft.isbn=&rft.btitle=&rft.title=Human+Mutation&rft.issn=10981004&rft_id=info:doi/10.1002%2Fhumu.21322 L2 - http://onlinelibrary.wiley.com/doi/10.1002/humu.21322/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-12-14 N1 - SubjectsTermNotLitGenreText - Common variable immunodeficiency; Exons; Lymphocytes B; Nucleotide sequence; Development; Infection; Computer programs; DNA sequencing; software; Single-nucleotide polymorphism; DNA; genomics; Mutation; Job's syndrome; Immunoglobulins DO - http://dx.doi.org/10.1002/humu.21322 ER - TY - JOUR T1 - Simultaneous myocardial strain and dark-blood perfusion imaging using a displacement-encoded MRI pulse sequence AN - 883029462; 15255551 AB - The purpose of this study is to develop and evaluate a displacement-encoded pulse sequence for simultaneous perfusion and strain imaging. Displacement-encoded images in two to three myocardial slices were repeatedly acquired using a single-shot pulse sequence for 3 to 4 min, which covers a bolus infusion of Gadolinium contrast. The magnitudes of the images were T1 weighted and provided quantitative measures of perfusion, while the phase maps yielded strain measurements. In an acute coronary occlusion swine protocol (n = 9), segmental perfusion measurements were validated against microsphere reference standard with a linear regression (slope 0.986, R2 = 0.765, Bland-Altman standard deviation = 0.15 mL/min/g). In a group of ST-elevation myocardial infarction patients (n = 11), the scan success rate was 76%. Short-term contrast washout rate and perfusion are highly correlated (R2 = 0.72), and the pixelwise relationship between circumferential strain and perfusion was better described with a sigmoidal Hill curve than linear functions. This study demonstrates the feasibility of measuring strain and perfusion from a single set of images. Magn Reson Med, 2010. [copy 2010 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Le, Yuan AU - Stein, Ashley AU - Berry, Colin AU - Kellman, Peter AU - Bennett, Eric E AU - Taylor, Joni AU - Lucas, Katherine AU - Kopace, Rael AU - Chefd'Hotel, Christophe AU - Lorenz, Christine H AU - Croisille, Pierre AU - Wen, Han AD - National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA, wenh@nhlbi.nih.gov wenh@nhlbi.nih.gov wenh@nhlbi.nih.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 787 EP - 798 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 64 IS - 3 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Perfusion KW - Standard deviation KW - Occlusion KW - Gadolinium KW - Magnetic resonance imaging KW - microspheres KW - N.M.R. KW - Maps KW - Myocardial infarction KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883029462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Simultaneous+myocardial+strain+and+dark-blood+perfusion+imaging+using+a+displacement-encoded+MRI+pulse+sequence&rft.au=Le%2C+Yuan%3BStein%2C+Ashley%3BBerry%2C+Colin%3BKellman%2C+Peter%3BBennett%2C+Eric+E%3BTaylor%2C+Joni%3BLucas%2C+Katherine%3BKopace%2C+Rael%3BChefd%27Hotel%2C+Christophe%3BLorenz%2C+Christine+H%3BCroisille%2C+Pierre%3BWen%2C+Han&rft.aulast=Le&rft.aufirst=Yuan&rft.date=2010-09-01&rft.volume=64&rft.issue=3&rft.spage=787&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22461 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22461/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Standard deviation; Perfusion; Occlusion; Magnetic resonance imaging; Gadolinium; microspheres; N.M.R.; Maps; Myocardial infarction DO - http://dx.doi.org/10.1002/mrm.22461 ER - TY - JOUR T1 - Activation of metallothionein transcription by 4-hydroxynonenal AN - 883015488; 15242278 AB - Metallothioneins (MTs) protect cells from oxidative damage by scavenging reactive oxygen species (ROS). Concurrent with protecting cells from ROS-mediated damage, MT transcription is induced by ROS. ROS activate transcription by affecting several signal transduction pathways, many of which have been implicated in regulating MT transcription. ROS-activated intracellular signaling is mediated by the stable lipid peroxide 4-hydroxynonenal (HNE). After determining the level of sensitivity of Hepa 1-6 cells to HNE, MT-1 mRNA expression was shown to be induced in a concentration and time-dependent manner after HNE exposure. Finally, using MT-based reporters, HNE was found to induce MT transcription via both antioxidant response and metal response elements. Thus, ROS may activate MT transcription by generating HNE that in turn affects signaling pathways that regulate MT transcription via the transcription factors AP-1 and MTF-1. [copy 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 24:330-334, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.20342 JF - Journal of Biochemical and Molecular Toxicology AU - Braithwaite, Elena K AU - Mattie, Michael D AU - Freedman, Jonathan H AD - Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA, freedma1@niehs.nih.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 330 EP - 334 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 24 IS - 5 SN - 1099-0461, 1099-0461 KW - Environment Abstracts; Toxicology Abstracts KW - Antioxidants KW - Biochemistry KW - Metallothionein KW - Lipids KW - Gene expression KW - 4-Hydroxynonenal KW - Reactive oxygen species KW - Sensitivity KW - Metals KW - Intracellular signalling KW - Regulatory sequences KW - Activator protein 1 KW - Lipid peroxidation KW - Oxygen KW - metallothioneins KW - Transcription factors KW - peroxide KW - Internet KW - Signal transduction KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883015488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biochemical+and+Molecular+Toxicology&rft.atitle=Activation+of+metallothionein+transcription+by+4-hydroxynonenal&rft.au=Braithwaite%2C+Elena+K%3BMattie%2C+Michael+D%3BFreedman%2C+Jonathan+H&rft.aulast=Braithwaite&rft.aufirst=Elena&rft.date=2010-09-01&rft.volume=24&rft.issue=5&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biochemical+and+Molecular+Toxicology&rft.issn=10990461&rft_id=info:doi/10.1002%2Fjbt.20342 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jbt.20342/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Intracellular signalling; Metals; Antioxidants; Metallothionein; Regulatory sequences; Activator protein 1; Lipid peroxidation; Gene expression; 4-Hydroxynonenal; Reactive oxygen species; Transcription factors; peroxide; Internet; Signal transduction; Sensitivity; Oxygen; Biochemistry; metallothioneins; Lipids DO - http://dx.doi.org/10.1002/jbt.20342 ER - TY - JOUR T1 - Assessment of a pesticide exposure intensity algorithm in the agricultural health study AN - 877599385; 13709743 AB - The accuracy of the exposure assessment is a critical factor in epidemiological investigations of pesticide exposures and health in agricultural populations. However, few studies have been conducted to evaluate questionnaire-based exposure metrics. The Agricultural Health Study (AHS) is a prospective cohort study of pesticide applicators who provided detailed questionnaire information on their use of specific pesticides. A field study was conducted for a subset of the applicators enrolled in the AHS to assess a pesticide exposure algorithm through comparison of algorithm intensity scores with measured exposures. Pre- and post-application urinary biomarker measurements were made for 2,4-D (n=69) and chlorpyrifos (n=17) applicators. Dermal patch, hand wipe, and personal air samples were also collected. Intensity scores were calculated using information from technician observations and an interviewer-administered questionnaire. Correlations between observer and questionnaire intensity scores were high (Spearman's r=0.92 and 0.84 for 2,4-D and chlorpyrifos, respectively). Intensity scores from questionnaires for individual applications were significantly correlated with post-application urinary concentrations for both 2,4-D (r=0.42, P<0.001) and chlorpyrifos (r=0.53, P=0.035) applicators. Significant correlations were also found between intensity scores and estimated hand loading, estimated body loading, and air concentrations for 2,4-D applicators (r-values 0.28-0.50, P-values<0.025). Correlations between intensity scores and dermal and air measures were generally lower for chlorpyrifos applicators using granular products. A linear regression model indicated that the algorithm factors for individual applications explained 24% of the variability in post-application urinary 2,4-D concentration, which increased to 60% when the pre-application urine concentration was included. The results of the measurements support the use of the algorithm for estimating questionnaire-based exposure intensities in the AHS for liquid pesticide products. Refinement of the algorithm may be possible using the results from this and other measurement studies. JF - Journal of Exposure Science and Environmental Epidemiology AU - Thomas, Kent W AU - Dosemeci, Mustafa AU - Coble, Joseph B AU - Hoppin, Jane A AU - Sheldon, Linda S AU - Chapa, Guadalupe AU - Croghan, Carry W AU - Jones, Paul A AU - Knott, Charles E AU - Lynch, Charles F AU - Sandler, Dale P AU - Blair, Aaron E AU - Alavanja, Michael C AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH/DHHS, Rockville, Maryland, USA Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 559 EP - 569 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 20 IS - 6 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts; Pollution Abstracts KW - 2,4-D KW - Algorithms KW - Air sampling KW - Regression analysis KW - 2,4-Dichlorophenoxyacetic acid KW - Bioindicators KW - Inventories KW - Skin KW - Hand KW - biomarkers KW - Chlorpyrifos KW - Urine KW - Pesticides KW - technicians KW - P 0000:AIR POLLUTION KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877599385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Assessment+of+a+pesticide+exposure+intensity+algorithm+in+the+agricultural+health+study&rft.au=Thomas%2C+Kent+W%3BDosemeci%2C+Mustafa%3BCoble%2C+Joseph+B%3BHoppin%2C+Jane+A%3BSheldon%2C+Linda+S%3BChapa%2C+Guadalupe%3BCroghan%2C+Carry+W%3BJones%2C+Paul+A%3BKnott%2C+Charles+E%3BLynch%2C+Charles+F%3BSandler%2C+Dale+P%3BBlair%2C+Aaron+E%3BAlavanja%2C+Michael+C&rft.aulast=Thomas&rft.aufirst=Kent&rft.date=2010-09-01&rft.volume=20&rft.issue=6&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2009.54 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Chlorpyrifos; 2,4-D; Inventories; Skin; Urine; Pesticides; Regression analysis; Algorithms; Hand; biomarkers; Bioindicators; Air sampling; 2,4-Dichlorophenoxyacetic acid; technicians DO - http://dx.doi.org/10.1038/jes.2009.54 ER - TY - JOUR T1 - Accidental Selection and Intentional Restoration of Sporulation-Deficient Bacillus anthracis Mutants AN - 877592165; 13679483 AB - We demonstrate the frequent accidental enrichment of spontaneous sporulation-deficient mutants of Bacillus anthracis on solid medium and identify contributing factors. Mutations in spo0A, encoding the master regulator of sporulation initiation, were found in 38 of 53 mutants. Transductions using bacteriophage CP51 propagated on sporogenic bacteria allowed for the restoration of sporulation phenotypes. JF - Applied and Environmental Microbiology AU - Sastalla, Inka AU - Rosovitz, MJ AU - Leppla, Stephen H AD - Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-3202, sleppla@niaid.nih.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 6318 EP - 6321 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 18 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - Phages KW - Sporulation KW - Bacillus anthracis KW - Mutation KW - A 01340:Antibiotics & Antimicrobials KW - X 24370:Natural Toxins KW - J 02430:Symbiosis, Antibiosis & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877592165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Accidental+Selection+and+Intentional+Restoration+of+Sporulation-Deficient+Bacillus+anthracis+Mutants&rft.au=Sastalla%2C+Inka%3BRosovitz%2C+MJ%3BLeppla%2C+Stephen+H&rft.aulast=Sastalla&rft.aufirst=Inka&rft.date=2010-09-01&rft.volume=76&rft.issue=18&rft.spage=6318&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00950-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 28 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Phages; Sporulation; Mutation; Bacillus anthracis DO - http://dx.doi.org/10.1128/AEM.00950-10 ER - TY - JOUR T1 - The NCI Alliance for Nanotechnology in Cancer: achievement and path forward AN - 869589810; 14821168 AB - Nanotechnology is a 'disruptive technology', which can lead to a generation of new diagnostic and therapeutic products, resulting in dramatically improved cancer outcomes. The National Cancer Institute (NCI) of National Institutes of Health explores innovative approaches to multidisciplinary research allowing for a convergence of molecular biology, oncology, physics, chemistry, and engineering and leading to the development of clinically worthy technological approaches. These initiatives include programmatic efforts to enable nanotechnology as a driver of advances in clinical oncology and cancer research, known collectively as the NCI Alliance for Nanotechnology in Cancer (ANC). Over the last 5 years, ANC has demonstrated that multidisciplinary approach catalyzes scientific developments and advances clinical translation in cancer nanotechnology. The research conducted by ANC members has improved diagnostic assays and imaging agents, leading to the development of point-of-care diagnostics, identification and validation of numerous biomarkers for novel diagnostic assays, and the development of multifunctional agents for imaging and therapy. Numerous nanotechnology-based technologies developed by ANC researchers are entering clinical trials. NCI has re-issued ANC program for next 5 years signaling that it continues to have high expectations for cancer nanotechnology's impact on clinical practice. The goals of the next phase will be to broaden access to cancer nanotechnology research through greater clinical translation and outreach to the patient and clinical communities and to support development of entirely new models of cancer care. WIREs Nanomed Nanobiotechnol 2010 2 450-460 JF - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology AU - Ptak, Krzysztof AU - Farrell, Dorothy AU - Panaro, Nicholas J AU - Grodzinski, Piotr AU - Barker, Anna D AD - Office of Cancer Nanotechnology Research, Center for Strategic Scientific Initiatives, National Cancer Institute, NIH, 31 Center Dr, Bethesda, MD 20892, USA, grodzinp@mail.nih.gov Y1 - 2010/09/01/ PY - 2010 DA - 2010 Sep 01 SP - 450 EP - 460 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK VL - 2 IS - 5 SN - 1939-0041, 1939-0041 KW - Biotechnology and Bioengineering Abstracts KW - Translation KW - Convergence KW - Computed tomography KW - Oncology KW - Development KW - biomarkers KW - Clinical trials KW - Cancer KW - nanotechnology KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869589810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.atitle=The+NCI+Alliance+for+Nanotechnology+in+Cancer%3A+achievement+and+path+forward&rft.au=Ptak%2C+Krzysztof%3BFarrell%2C+Dorothy%3BPanaro%2C+Nicholas+J%3BGrodzinski%2C+Piotr%3BBarker%2C+Anna+D&rft.aulast=Ptak&rft.aufirst=Krzysztof&rft.date=2010-09-01&rft.volume=2&rft.issue=5&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.issn=19390041&rft_id=info:doi/10.1002%2Fwnan.98 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Translation; Convergence; Computed tomography; Oncology; Development; Clinical trials; biomarkers; Cancer; Models; nanotechnology DO - http://dx.doi.org/10.1002/wnan.98 ER - TY - JOUR T1 - The frequency-dependence of the nicotine-induced inhibition of dopamine is controlled by the a7 nicotinic receptor AN - 867741147; 13823806 AB - J. Neurochem. (2010) 114, 1659-1666.AbstractVoltammetric analyses show that low (100-500 nM) doses of nicotine regulate striatal dopamine by inhibiting release evoked by a single stimulation to a greater extent than release evoked by high frequency stimulations. This frequency-dependent inhibition is because of nicotine desensitizing heteromeric b2 subunit-containing nicotinic acetylcholine receptor (nAChR) subtypes. Surprisingly, a high dose of nicotine (2 kM; capable of interacting with additional nAChR subtypes) produced an inhibition of dopamine evoked by high frequency stimulation, an effect that was not seen with the low dose of nicotine or the b2 antagonist, dihydro-b-erythroidine hydrobromide. This inhibition was replicated by application of a7 nAChR antagonists methyllcaconitine citrate or a-bungarotoxin in conjunction with the low dose of nicotine or dihydro-b-erythroidine hydrobromide. Blocking a7 receptor function alone produced a modest increase in dopamine evoked by single pulse stimulation while not affecting dopamine evoked by high frequency stimulation. The antagonist results were mimicked using selective a7 agonists PHA 543613 and PNU 282987. The frequency dependence of the low dose nicotine inhibition therefore requires functional a7 nAChRs, and may arise from differing levels of endogenous acetylcholine evoked by the stimulation. JF - Journal of Neurochemistry AU - Seipel, Andrew T AU - Yakel, Jerrel L AD - Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA, yakel@niehs.nih.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1659 EP - 1666 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 114 IS - 6 SN - 0022-3042, 0022-3042 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Acetylcholine receptors (nicotinic) KW - Bungarotoxin KW - Citric acid KW - Dopamine KW - Frequency dependence KW - Neostriatum KW - Nicotine KW - Receptor mechanisms KW - X 24380:Social Poisons & Drug Abuse KW - N3 11008:Neurochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867741147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=The+frequency-dependence+of+the+nicotine-induced+inhibition+of+dopamine+is+controlled+by+the+a7+nicotinic+receptor&rft.au=Seipel%2C+Andrew+T%3BYakel%2C+Jerrel+L&rft.aulast=Seipel&rft.aufirst=Andrew&rft.date=2010-09-01&rft.volume=114&rft.issue=6&rft.spage=1659&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/10.1111%2Fj.1471-4159.2010.06883.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Number of references - 25 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Dopamine; Bungarotoxin; Receptor mechanisms; Nicotine; Neostriatum; Frequency dependence; Acetylcholine receptors (nicotinic); Citric acid DO - http://dx.doi.org/10.1111/j.1471-4159.2010.06883.x ER - TY - JOUR T1 - Targeting botulinum neurotoxin persistence by the ubiquitin-proteasome system AN - 856755295; 13911768 AB - Botulinum neurotoxins (BoNTs) are the most potent natural toxins known. The effects of BoNT serotype A (BoNT/A) can last several months, whereas the effects of BoNT serotype E (BoNT/E), which shares the same synaptic target, synaptosomal-associated protein 25 (SNAP25), last only several weeks. The long-lasting effects or persistence of BoNT/A, although desirable for therapeutic applications, presents a challenge for medical treatment of BoNT intoxication. Although the mechanisms for BoNT toxicity are well known, little is known about the mechanisms that govern the persistence of the toxins. We show that the recombinant catalytic light chain (LC) of BoNT/E is ubiquitylated and rapidly degraded in cells. In contrast, BoNT/A LC is considerably more stable. Differential susceptibility of the catalytic LCs to ubiquitin-dependent proteolysis therefore might explain the differential persistence of BoNT serotypes. In this regard we show that TRAF2, a RING finger protein implicated in ubiquitylation, selectively associates with BoNT/E LC and promotes its proteasomal degradation. Given these data, we asked whether BoNT/A LC could be targeted for rapid proteasomal degradation by redirecting it to characterized ubiquitin ligase domains. We describe chimeric SNAP25-based ubiquitin ligases that target BoNT/A LC for degradation, reducing its duration in a cellular model for toxin persistence. JF - Proceedings of the National Academy of Sciences, USA AU - Tsai, Yien Che AU - Maditz, Rhyan AU - Kuo, Chueh-ling AU - Fishman, Paul S AU - Shoemaker, Charles B AU - Oyler, George A AU - Weissman, Allan M AD - Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702 Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 16554 EP - 16559 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 107 IS - 38 SN - 0027-8424, 0027-8424 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Botulinum toxin KW - Botulinum toxin type A KW - Data processing KW - Intoxication KW - Light chains KW - Proteolysis KW - RING finger proteins KW - SNAP-25 protein KW - Serotypes KW - TRAF2 protein KW - Therapeutic applications KW - Toxicity KW - Ubiquitin KW - Ubiquitin-protein ligase KW - proteasomes KW - X 24370:Natural Toxins KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856755295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Targeting+botulinum+neurotoxin+persistence+by+the+ubiquitin-proteasome+system&rft.au=Tsai%2C+Yien+Che%3BMaditz%2C+Rhyan%3BKuo%2C+Chueh-ling%3BFishman%2C+Paul+S%3BShoemaker%2C+Charles+B%3BOyler%2C+George+A%3BWeissman%2C+Allan+M&rft.aulast=Tsai&rft.aufirst=Yien&rft.date=2010-09-01&rft.volume=107&rft.issue=38&rft.spage=16554&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.1008302107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Intoxication; Proteolysis; Light chains; Serotypes; Data processing; proteasomes; Therapeutic applications; RING finger proteins; Toxicity; Botulinum toxin type A; TRAF2 protein; Ubiquitin-protein ligase; SNAP-25 protein; Botulinum toxin; Ubiquitin DO - http://dx.doi.org/10.1073/pnas.1008302107 ER - TY - JOUR T1 - Reproduction-Longevity Trade-Off in Anopheles gambiae (Diptera: Culicidae) AN - 853478863; 14078020 AB - Reduced survival and future reproduction due to of current reproduction is a trade-off known as the cost of reproduction. Surprisingly, only a few studies have assessed the cost of reproduction in arthropod disease vectors, despite its effect on longevity, and thus on vectorial capacity. We evaluated the cost of reproduction on survival of Anopheles gambiae Giles by comparing mosquitoes that were denied exposure to the other sex, hereafter named virgins, and those that were allowed exposure to the other sex and mating, hereafter named mated. Merely 6 d of exposure to females with mating activity reduced male survival from a median of 17 d in virgins to 15 d in mated, indicating that male mating cost is substantial. The increase in mortality of mated males began several days after the exposure to females ended, indicating that mating is not associated with immediate mortality risk. Notably, body size was negatively correlated with male mortality in mated males, but not in virgins. The rate of insemination declined after 4 d of exposure to females, indicating that male mating capacity is limited and further supporting the hypothesis that mating is costly for males. Consistent with previous studies, female survival on sugar alone (median = 16 d) was shorter than on blood and sugar (median = 19 d), regardless if she was mated or virgin. Overall, survival of mated females was lower than that of virgins on a diet of blood and sugar, but no difference was found on a diet of sugar only. However, the cost of reproduction in females remains ambiguous because the difference in survival between virgin and mated females was driven by the difference between virgin (median = 19 d) and uninseminated females exposed to males (median = 17 d), rather than between virgin and inseminated females (median = 19 d). Accordingly, sperm and seminal fluid, egg development, and oviposition have negligible cost in terms of female survival. Only exposure to males without insemination decreased female survival, Nonetheless, if exposure to males under natural conditions is also associated with reduced survival, it might explain why females remain monogamous. JF - Journal of Medical Entomology AU - Dao, Adama AU - Kassogue, Yaya AU - Adamou, Abdoulaye AU - Diallo, Moussa AU - Yaro, Alpha Seydou AU - Traore, Sekou F AU - Lehmann, Tovi Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 769 EP - 777 PB - Entomological Society of America, 9301 Annapolis Rd. Lanham MD 20706 USA VL - 47 IS - 5 SN - 0022-2585, 0022-2585 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Entomology Abstracts KW - Anopheles gambiae KW - survival KW - body size KW - cost of reproduction KW - mating KW - Survival KW - Sperm KW - Biological fertilization KW - Public health KW - Mating KW - Body size KW - Reproductive behaviour KW - Aquatic insects KW - Sex KW - Diets KW - Mortality KW - Sugar KW - Vectors KW - Culicidae KW - Pest control KW - Longevity KW - Entomology KW - Blood KW - Arthropoda KW - Reproduction KW - Seminal fluid KW - Diptera KW - Oviposition KW - Mortality causes KW - Q1 08442:Population dynamics KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853478863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Entomology&rft.atitle=Reproduction-Longevity+Trade-Off+in+Anopheles+gambiae+%28Diptera%3A+Culicidae%29&rft.au=Dao%2C+Adama%3BKassogue%2C+Yaya%3BAdamou%2C+Abdoulaye%3BDiallo%2C+Moussa%3BYaro%2C+Alpha+Seydou%3BTraore%2C+Sekou+F%3BLehmann%2C+Tovi&rft.aulast=Dao&rft.aufirst=Adama&rft.date=2010-09-01&rft.volume=47&rft.issue=5&rft.spage=769&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Entomology&rft.issn=00222585&rft_id=info:doi/10.1603%2FME10052 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Number of references - 47 N1 - Last updated - 2014-10-30 N1 - SubjectsTermNotLitGenreText - Survival; Reproduction; Pest control; Reproductive behaviour; Biological fertilization; Aquatic insects; Entomology; Mortality causes; Public health; Diets; Sugar; Mortality; Vectors; Sperm; Longevity; Mating; Blood; Body size; Seminal fluid; Oviposition; Sex; Arthropoda; Culicidae; Diptera; Anopheles gambiae DO - http://dx.doi.org/10.1603/ME10052 ER - TY - JOUR T1 - Similarities in speech and white matter characteristics in idiopathic developmental stuttering and adult-onset stuttering AN - 853229764; llba-201018321 AB - Adult-onset stuttering (AS) typically occurs following neurological and/or psychological trauma, considered different from developmental stuttering (DS), which starts during early childhood with few if any new cases reported after adolescence. Here we report four cases of AS, two with apparent psychological trigger and two without, none with evidence of neurological injury, and none conforming to previously reported characteristics of psychogenic stuttering. We asked whether this group of AS would have similar speech and neuroanatomical characteristics to those with DS. We conducted blinded analyses of speech samples in four AS cases and 14 cases of DS on type, frequency, and loci of disfluencies. Diffusion tensor imaging (DTI) was conducted to compare white matter tracts using fractional anisotropy (FA). We found that AS did not differ significantly from DS in any of the speech characteristics measured. On DTI, DS had significantly increased FA relative to controls in the right superior longitudinal tract. AS cases showed a similar trend for increases in these regions when compared to controls. The results of this study suggest that symptoms of idiopathic stuttering can begin during adulthood, and that similar neuroanatomical differences from controls may be associated with both developmental and adult-onset idiopathic stuttering. [Copyright Elsevier Ltd.] JF - Journal of Neurolinguistics AU - Chang, Soo-Eun AU - Synnestvedt, Anna AU - Ostuni, John AU - Ludlow, Christy L AD - Laryngeal and Speech Section, Medical Neurology Branch, NINDS/NIH, 10 Center Drive MSC 1416, Building 10, Room 5D38, Bethesda, MD 20892, USA ludlowc@ninds.nih.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 455 EP - 469 VL - 23 IS - 5 SN - 0911-6044, 0911-6044 KW - *Age of Onset (01157) KW - *Children (11850) KW - *Adults (00600) KW - *Stuttering (84850) KW - *Brain Damage (09400) KW - article KW - 6410: language-pathological and normal; language and speech pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853229764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurolinguistics&rft.atitle=Similarities+in+speech+and+white+matter+characteristics+in+idiopathic+developmental+stuttering+and+adult-onset+stuttering&rft.au=Chang%2C+Soo-Eun%3BSynnestvedt%2C+Anna%3BOstuni%2C+John%3BLudlow%2C+Christy+L&rft.aulast=Chang&rft.aufirst=Soo-Eun&rft.date=2010-09-01&rft.volume=23&rft.issue=5&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurolinguistics&rft.issn=09116044&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2010-09-01 N1 - Last updated - 2014-06-17 N1 - CODEN - JONEE8 N1 - SubjectsTermNotLitGenreText - *Stuttering (84850); *Adults (00600); *Brain Damage (09400); *Children (11850); *Age of Onset (01157) ER - TY - JOUR T1 - Cyanobacterial blooms and the occurrence of the neurotoxin, beta-N-methylamino-l-alanine (BMAA), in South Florida aquatic food webs AN - 839645111; 13512915 AB - Recent studies demonstrate that most cyanobacteria produce the neurotoxin beta-N-methylamino-l-alanine (BMAA) and that it can biomagnify in at least one terrestrial food chain. BMAA has been implicated as a significant environmental risk in the development of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis (ALS). We examined several blooms of cyanobacteria in South Florida, and the BMAA content of resident animals, including species used as human food. A wide range of BMAA concentrations were found, ranging from below assay detection limits to approximately 7000I14g/g, a concentration associated with a potential long-term human health hazard. JF - Harmful Algae AU - Brand, Larry E AU - Pablo, John AU - Compton, Angela AU - Hammerschlag, Neil AU - Mash, Deborah C AD - Division of Marine Biology and Fisheries and NSF/NIEHS Oceans and Human Health Center, Rosenstiel School of Marine and Atmospheric Science, University of Miami, 4600 Rickenbacker Cswy., Miami, FL 33149, United States Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 620 EP - 635 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 9 IS - 6 SN - 1568-9883, 1568-9883 KW - Toxicology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - BMAA KW - Cyanobacteria KW - Florida KW - Harmful algal blooms KW - Neurodegenerative disease KW - Toxin KW - Algal blooms KW - Food chains KW - USA, Florida KW - Biological poisons KW - Parkinson's disease KW - Alzheimer's disease KW - Human food KW - Phytoplankton KW - Public health KW - Neurodegenerative diseases KW - Amyotrophic lateral sclerosis KW - Movement disorders KW - Neurotoxins KW - Food webs KW - Algae KW - X 24370:Natural Toxins KW - Q1 08484:Species interactions: parasites and diseases KW - O 5060:Aquaculture KW - K 03450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839645111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Harmful+Algae&rft.atitle=Cyanobacterial+blooms+and+the+occurrence+of+the+neurotoxin%2C+beta-N-methylamino-l-alanine+%28BMAA%29%2C+in+South+Florida+aquatic+food+webs&rft.au=Brand%2C+Larry+E%3BPablo%2C+John%3BCompton%2C+Angela%3BHammerschlag%2C+Neil%3BMash%2C+Deborah+C&rft.aulast=Brand&rft.aufirst=Larry&rft.date=2010-09-01&rft.volume=9&rft.issue=6&rft.spage=620&rft.isbn=&rft.btitle=&rft.title=Harmful+Algae&rft.issn=15689883&rft_id=info:doi/10.1016%2Fj.hal.2010.05.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2014-09-18 N1 - SubjectsTermNotLitGenreText - Algal blooms; Cyanobacteria; Food chains; Biological poisons; Human food; Phytoplankton; Neurotoxins; Food webs; Public health; Neurodegenerative diseases; Movement disorders; Amyotrophic lateral sclerosis; Parkinson's disease; Alzheimer's disease; Algae; USA, Florida DO - http://dx.doi.org/10.1016/j.hal.2010.05.002 ER - TY - JOUR T1 - Informing Innovation: Tracking Student Interest in Emerging Library Technologies at Ohio University AN - 839635499; 201100029 AB - Book review abstract. Informing Innovation: Tracking Student Interest in Emerging Library Technologies at Ohio University. By Char Booth. Chicago, IL: American Library Association, 2009, 136pp., 46.00 USD. ISBN 978-0-8389-8526-7. Reviewed by Betty Landesman. [Copyright Elsevier Inc.] JF - Serials Review AU - Landesman, Betty AU - Landesman, Betty AD - Digital Resources and Metadata, NIH Library, National Institutes of Health, Bethesda, MD 20892-1150, USA landesb@mail.nih.gov Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 199 EP - 200 PB - Elsevier, San Diego CA VL - 36 IS - 3 SN - 0098-7913, 0098-7913 KW - University libraries KW - Students KW - Library technology KW - article KW - 1.11: BOOK REVIEWS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839635499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Serials+Review&rft.atitle=Informing+Innovation%3A+Tracking+Student+Interest+in+Emerging+Library+Technologies+at+Ohio+University&rft.au=Landesman%2C+Betty&rft.aulast=Landesman&rft.aufirst=Betty&rft.date=2010-09-01&rft.volume=36&rft.issue=3&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Serials+Review&rft.issn=00987913&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Library technology; Students; University libraries ER - TY - JOUR T1 - Data-Driven Methodology Illustrating Mechanisms Underlying Word List Recall: Applications to Clinical Research AN - 822515468; 201022588 AB - Objective: Word list learning tasks such as the California Verbal Learning Test (CVLT; Delis, Kramer, Kaplan, & Ober, 1987) are widely used to investigate recall strategies. Participants who recall the most words generally employ semantic techniques, whereas those with poor recall (e.g., patients with schizophrenia) rely on serial techniques. However, these conclusions are based on formulas that assume that categories reflect semantic associations, bind strategy to overall performance, and neglect strategy changes over 5 trials. Therefore, we derived novel measures-independent of recall performance-to compute strategies across trials and identify whether diagnosis predicts recall strategy. Method: Participants were included on the basis of performance on the CVLT (i.e., total words recalled over 5 trials). The 50 highest and 50 lowest performers among healthy volunteers (n = 100) and patients with schizophrenia (n = 100) were selected. Novel measures of recall and transition probability were calculated and analyzed by permutation tests. Results: Recall patterns and strategies of patients resembled those of controls with similar performance levels: Regardless of diagnosis, low performers were more likely to recall the first 2 and last 4 items from the list; high performers increased engagement of semantically based transitions across the 5 trials, whereas low performers did not. Conclusions: Cognitive strategy must be considered independent of overall performance before attributing poor performance to degraded learning processes. Our results demonstrate the importance of departing from global scoring techniques, especially when working with clinical populations such as patients with schizophrenia for whom episodic memory deficits are a hallmark feature. [Copyright The American Psychological Association.] JF - Neuropsychology AU - Longenecker, Julia AU - Kohn, Philip AU - Liu, Stanley AU - Zoltick, Brad AU - Weinberger, Daniel R AU - Elvevag, Brita AD - Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD brita@elvevaag.net Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 625 EP - 636 VL - 24 IS - 5 SN - 0894-4105, 0894-4105 KW - Cognitive Processes (12950) KW - Patients (62950) KW - Schizophrenia (75250) KW - Recall (Memory) (71700) KW - Learning Strategies (46000) KW - Word Lists (97665) KW - article KW - 4016: psycholinguistics; verbal learning: paired associate, serial learning, memory, recognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822515468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychology&rft.atitle=Data-Driven+Methodology+Illustrating+Mechanisms+Underlying+Word+List+Recall%3A+Applications+to+Clinical+Research&rft.au=Longenecker%2C+Julia%3BKohn%2C+Philip%3BLiu%2C+Stanley%3BZoltick%2C+Brad%3BWeinberger%2C+Daniel+R%3BElvevag%2C+Brita&rft.aulast=Longenecker&rft.aufirst=Julia&rft.date=2010-09-01&rft.volume=24&rft.issue=5&rft.spage=625&rft.isbn=&rft.btitle=&rft.title=Neuropsychology&rft.issn=08944105&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2010-12-01 N1 - Last updated - 2016-09-27 N1 - CODEN - NEUPEG N1 - SubjectsTermNotLitGenreText - Recall (Memory) (71700); Word Lists (97665); Schizophrenia (75250); Patients (62950); Cognitive Processes (12950); Learning Strategies (46000) ER - TY - JOUR T1 - Narrative Empathy and How Dealing with Stories Helps: Creating a Space for Empathy in Culturally Diverse Care Settings AN - 822497650; 201032221 AB - Abstract not available. JF - Journal of Pain and Symptom Management AU - Moore, Rhonda J AU - Hallenbeck, James AD - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 471 EP - 476 PB - Elsevier, New York NY VL - 40 IS - 3 SN - 0885-3924, 0885-3924 KW - Cultural diversity KW - Narratives KW - Empathy KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822497650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pain+and+Symptom+Management&rft.atitle=Narrative+Empathy+and+How+Dealing+with+Stories+Helps%3A+Creating+a+Space+for+Empathy+in+Culturally+Diverse+Care+Settings&rft.au=Moore%2C+Rhonda+J%3BHallenbeck%2C+James&rft.aulast=Moore&rft.aufirst=Rhonda&rft.date=2010-09-01&rft.volume=40&rft.issue=3&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pain+and+Symptom+Management&rft.issn=08853924&rft_id=info:doi/10.1016%2Fj.jpainsymman.2010.03.013 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-12-16 N1 - Last updated - 2016-09-27 N1 - CODEN - JSPME2 N1 - SubjectsTermNotLitGenreText - Empathy; Narratives; Cultural diversity DO - http://dx.doi.org/10.1016/j.jpainsymman.2010.03.013 ER - TY - JOUR T1 - Genetic Restoration of the Florida Panther AN - 817606935; 13899323 AB - The rediscovery of remnant Florida panthers (Puma concolor coryi) in southern Florida swamplands prompted a program to protect and stabilize the population. In 1995, conservation managers translocated eight female pumas (P. c. stanleyana) from Texas to increase depleted genetic diversity, improve population numbers, and reverse indications of inbreeding depression. We have assessed the demographic, population-genetic, and biomedical consequences of this restoration experiment and show that panther numbers increased threefold, genetic heterozygosity doubled, survival and fitness measures improved, and inbreeding correlates declined significantly. Although these results are encouraging, continued habitat loss, persistent inbreeding, infectious agents, and possible habitat saturation pose new dilemmas. This intensive management program illustrates the challenges of maintaining populations of large predators worldwide. JF - Science (Washington) AU - Johnson, Warren E AU - Onorato, David P AU - Roelke, Melody E AU - Land, EDarrell AU - Cunningham, Mark AU - Belden, Robert C AU - McBride, Roy AU - Jansen, Deborah AU - Lotz, Mark AU - Shindle, David AU - Howard, JoGayle AU - Wildt, David E AU - Penfold, Linda M AU - Hostetler, Jeffrey A AU - Oli, Madan K AU - O'Brien, Stephen J AD - Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA, stephenobrien@nih.gov stephenobrien@nih.gov stephenobrien@nih.gov stephenobrien@nih.gov stephenobrien@nih.gov stephenobrien@nih.gov stephenobrien@nih.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1641 EP - 1645 PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 USA VL - 329 IS - 5999 SN - 0036-8075, 0036-8075 KW - Genetics Abstracts; Sustainability Science Abstracts; Aqualine Abstracts; Water Resources Abstracts KW - demography KW - Fitness KW - USA, Florida KW - Survival KW - Genetic diversity KW - Predators KW - Florida panthers KW - pumas KW - Demography KW - Population genetics KW - Habitats KW - Inbreeding depression KW - Saturation KW - Habitat KW - Heterozygosity KW - predators KW - inbreeding KW - Conservation KW - Inbreeding KW - USA, Texas KW - survival KW - AQ 00001:Water Resources and Supplies KW - M3 1010:Issues in Sustainable Development KW - G 07750:Ecological & Population Genetics KW - SW 0540:Properties of water UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/817606935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=Genetic+Restoration+of+the+Florida+Panther&rft.au=Johnson%2C+Warren+E%3BOnorato%2C+David+P%3BRoelke%2C+Melody+E%3BLand%2C+EDarrell%3BCunningham%2C+Mark%3BBelden%2C+Robert+C%3BMcBride%2C+Roy%3BJansen%2C+Deborah%3BLotz%2C+Mark%3BShindle%2C+David%3BHoward%2C+JoGayle%3BWildt%2C+David+E%3BPenfold%2C+Linda+M%3BHostetler%2C+Jeffrey+A%3BOli%2C+Madan+K%3BO%27Brien%2C+Stephen+J&rft.aulast=Johnson&rft.aufirst=Warren&rft.date=2010-09-01&rft.volume=329&rft.issue=5999&rft.spage=1641&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1192891 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-12-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Demography; Fitness; Population genetics; Inbreeding depression; Genetic diversity; Conservation; Survival; Predators; Inbreeding; Habitat; Heterozygosity; demography; inbreeding; survival; Florida panthers; predators; pumas; Habitats; Saturation; USA, Florida; USA, Texas DO - http://dx.doi.org/10.1126/science.1192891 ER - TY - JOUR T1 - Hemocyte Differentiation Mediates Innate Immune Memory in Anopheles gambiae Mosquitoes AN - 817606887; 13899279 AB - Mosquito midgut invasion by ookinetes of the malaria parasite Plasmodium disrupts the barriers that normally prevent the gut microbiota from coming in direct contact with epithelial cells. This triggers a long-lived response characterized by increased abundance of granulocytes, a subpopulation of hemocytes that circulates in the insect's hemocoel, and enhanced immunity to bacteria that indirectly reduces survival of Plasmodium parasites upon reinfection. In mosquitoes, differentiation of hemocytes was necessary and sufficient to confer innate immune memory. JF - Science (Washington) AU - Rodrigues, Janneth AU - Brayner, Fabio Andre AU - Alves, Luiz Carlos AU - Dixit, Rajnikant AU - Barillas-Mury, Carolina AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA, cbarillas@niaid.nih.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1353 EP - 1355 PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 USA VL - 329 IS - 5997 SN - 0036-8075, 0036-8075 KW - Immunology Abstracts; Entomology Abstracts; CSA Neurosciences Abstracts; ASFA Aquaculture Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Oceanic Abstracts KW - Epithelial cells KW - Parasites KW - Human diseases KW - Barriers KW - Zygotes KW - Hemocoel KW - Subpopulations KW - Immunological memory KW - Malaria KW - Immunity KW - Population dynamics KW - Anopheles gambiae KW - Public health KW - Differentiation KW - Leukocytes (granulocytic) KW - Plasmodium KW - Digestive tract KW - Hemocytes KW - Midgut KW - Aquatic insects KW - O 1070:Ecology/Community Studies KW - Q1 08484:Species interactions: parasites and diseases KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms KW - N3 11024:Neuroimmunology KW - Q3 08587:Diseases of Cultured Organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/817606887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=Hemocyte+Differentiation+Mediates+Innate+Immune+Memory+in+Anopheles+gambiae+Mosquitoes&rft.au=Rodrigues%2C+Janneth%3BBrayner%2C+Fabio+Andre%3BAlves%2C+Luiz+Carlos%3BDixit%2C+Rajnikant%3BBarillas-Mury%2C+Carolina&rft.aulast=Rodrigues&rft.aufirst=Janneth&rft.date=2010-09-01&rft.volume=329&rft.issue=5997&rft.spage=1353&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1190689 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-12-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Barriers; Subpopulations; Malaria; Immunity; Population dynamics; Aquatic insects; Public health; Epithelial cells; Leukocytes (granulocytic); Differentiation; Digestive tract; Zygotes; Hemocoel; Immunological memory; Hemocytes; Midgut; Plasmodium; Anopheles gambiae DO - http://dx.doi.org/10.1126/science.1190689 ER - TY - JOUR T1 - Characterization of the Effects of Aryl-azido Compounds and UVA Irradiation on the Viral Proteins and Infectivity of Human Immunodeficiency Virus Type 1 AN - 807276309; 13824783 AB - AbstractHydrophobic UV-activatable compounds have been shown to partition into the hydrophobic region of biological membranes to selectively label transmembrane proteins, and to inactivate enveloped viruses. Here, we analyze various UV-activatable azido- and iodo-based hydrophobic compounds for their ability to inactivate a model-enveloped virus, human immunodeficiency virus (HIV-1 MN). Treatment of HIV-1 with 1,5-diazidonapthalene (DAN), 1-iodo, 5-azidonaphthalene (INA), 1-azidonaphthalene (AzNAP) or 4,4'-diazidobiphenyl (DABIPH) followed by UVA irradiation for 2 min resulted in complete viral inactivation, whereas treatment using analogous non-azido-containing controls had no effect. Incorporation of an azido moiety within these hydrophobic compounds to promote photoinduced covalent reactions with proteins was found to be the primary mechanism of viral inactivation for this class of compounds. Prolonged UVA irradiation of the virus in the presence of these azido compounds resulted in further modifications of viral proteins, due to the generation of reactive oxygen species, leading to aggregation as visualized via Western blot analysis, providing additional viral modifications that may inhibit viral infectivity. Furthermore, inactivation using these compounds resulted in the preservation of surface antigenic structures (recognized by neutralizing antibodies b12, 2g12 and 4e10), which is favorable for the creation of vaccines from these inactivated virus preparations. JF - Photochemistry and Photobiology AU - Belanger, Julie M AU - Raviv, Yossef AU - Viard, Mathias AU - Jason de la Cruz, Michael AU - Nagashima, Kunio AU - Blumenthal, Robert AD - 1Center for Cancer Research Nanobiology Program, NCI-Frederick, Frederick, MD, USA Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1099 EP - 1108 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 86 IS - 5 SN - 0031-8655, 0031-8655 KW - Immunology Abstracts; Virology & AIDS Abstracts; Toxicology Abstracts KW - Western blotting KW - Infectivity KW - Antibodies KW - U.V. radiation KW - Reactive oxygen species KW - Human immunodeficiency virus 1 KW - Hydrophobicity KW - Vaccines KW - Membrane proteins KW - Preservation KW - Manganese KW - X 24390:Radioactive Materials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807276309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+Photobiology&rft.atitle=Characterization+of+the+Effects+of+Aryl-azido+Compounds+and+UVA+Irradiation+on+the+Viral+Proteins+and+Infectivity+of+Human+Immunodeficiency+Virus+Type+1&rft.au=Belanger%2C+Julie+M%3BRaviv%2C+Yossef%3BViard%2C+Mathias%3BJason+de+la+Cruz%2C+Michael%3BNagashima%2C+Kunio%3BBlumenthal%2C+Robert&rft.aulast=Belanger&rft.aufirst=Julie&rft.date=2010-09-01&rft.volume=86&rft.issue=5&rft.spage=1099&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+Photobiology&rft.issn=00318655&rft_id=info:doi/10.1111%2Fj.1751-1097.2010.00780.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Number of references - 36 N1 - Last updated - 2013-07-26 N1 - SubjectsTermNotLitGenreText - Western blotting; Antibodies; Infectivity; U.V. radiation; Reactive oxygen species; Hydrophobicity; Preservation; Membrane proteins; Vaccines; Manganese; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1111/j.1751-1097.2010.00780.x ER - TY - JOUR T1 - Measuring addiction propensity and severity: The need for a new instrument AN - 772276066; 201029810 AB - Drug addiction research requires but lacks a valid and reliable way to measure both the risk (propensity) to develop addiction and the severity of manifest addiction. This paper argues for a new measurement approach and instrument to quantify propensity to and severity of addiction, based on the testable assumption that these constructs can be mapped onto the same dimension of liability to addiction. The case for this new direction becomes clear from a critical review of empirical data and the current instrumentation. The many assessment instruments in use today have proven utility, reliability, and validity, but they are of limited use for evaluating individual differences in propensity and severity. The conceptual and methodological shortcomings of instruments currently used in research and clinical practice can be overcome through the use of new technologies to develop a reliable, valid, and standardized assessment instrument(s) to measure and distinguish individual variations in expression of the underlying latent trait(s) that comprises propensity to and severity of drug addiction. Such instrumentation would enhance our capacity for drug addiction research on linkages and interactions among familial, genetic, psychosocial, and neurobiological factors associated with variations in propensity and severity. It would lead to new opportunities in substance abuse prevention, treatment, and services research, as well as in interventions and implementation science for drug addiction. [Copyright Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Conway, Kevin P AU - Levy, Janet AU - Vanyukov, Michael AU - Chandler, Redonna AU - Rutter, Joni AU - Swan, Gary E AU - Neale, Michael AD - Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 6001 Executive Blvd., Room 5153, MSC 9589, Bethesda, MD 20892-9589, USA kconway@nida.nih.gov Y1 - 2010/09/01/ PY - 2010 DA - 2010 Sep 01 SP - 4 EP - 12 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 111 IS - 1-2 SN - 0376-8716, 0376-8716 KW - Tobacco Cannabis assessment Individual differences Adolescents KW - Clinical assessment KW - Severity KW - Psychosocial factors KW - Addiction KW - Drug addiction KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/772276066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Measuring+addiction+propensity+and+severity%3A+The+need+for+a+new+instrument&rft.au=Conway%2C+Kevin+P%3BLevy%2C+Janet%3BVanyukov%2C+Michael%3BChandler%2C+Redonna%3BRutter%2C+Joni%3BSwan%2C+Gary+E%3BNeale%2C+Michael&rft.aulast=Conway&rft.aufirst=Kevin&rft.date=2010-09-01&rft.volume=111&rft.issue=1-2&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2010.03.011 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-11-11 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Drug addiction; Severity; Addiction; Substance abuse; Clinical assessment; Psychosocial factors DO - http://dx.doi.org/10.1016/j.drugalcdep.2010.03.011 ER - TY - JOUR T1 - Turning Points and Lessons Learned: Stressful Life Events and Personality Trait Development Across Middle Adulthood AN - 772265774; 201030901 AB - The present research examined stressful life events and personality development across middle adulthood. Participants (N = 533) related the most stressful event they had experienced within the last 10 years, indicated whether they considered the event to be a turning point and/or lesson learned, and twice completed a comprehensive measure of traits defined by the five-factor model of personality; the stressful event occurred between these two assessments. Descriptions were coded to classify events into broad content domains based on the nature of the event. Prospectively, individuals high in Neuroticism perceived the event as a turning point; extraverts learned a lesson from it. Longitudinally, perceiving the event as a negative turning point was associated with increases in Neuroticism, whereas learning a lesson from the event was associated with increases in Extraversion and Conscientiousness. Characteristics of the events themselves were primarily unrelated to trait change. Across middle adulthood, personality trait change may be more strongly related to how individuals understand the stressful events in their lives rather than simply the occurrence of such events. [Copyright American Psychological Association] JF - Psychology and Aging AU - Sutin, Angelina R AU - Costa, Paul T, Jr AU - Wethington, Elaine AU - Eaton, William Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 524 EP - 533 PB - American Psychological Association, Washington DC VL - 25 IS - 3 SN - 0882-7974, 0882-7974 KW - five-factor model personality narrative life events turning points KW - Adulthood KW - Neuroticism KW - Personality KW - Personality development KW - Stressful events KW - Turning points KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/772265774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+and+Aging&rft.atitle=Turning+Points+and+Lessons+Learned%3A+Stressful+Life+Events+and+Personality+Trait+Development+Across+Middle+Adulthood&rft.au=Sutin%2C+Angelina+R%3BCosta%2C+Paul+T%2C+Jr%3BWethington%2C+Elaine%3BEaton%2C+William&rft.aulast=Sutin&rft.aufirst=Angelina&rft.date=2010-09-01&rft.volume=25&rft.issue=3&rft.spage=524&rft.isbn=&rft.btitle=&rft.title=Psychology+and+Aging&rft.issn=08827974&rft_id=info:doi/10.1037%2Fa0018751 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-11-11 N1 - Last updated - 2016-09-27 N1 - CODEN - PAGIEL N1 - SubjectsTermNotLitGenreText - Stressful events; Turning points; Personality; Adulthood; Neuroticism; Personality development DO - http://dx.doi.org/10.1037/a0018751 ER - TY - JOUR T1 - Cannabis withdrawal symptoms in non-treatment-seeking adult cannabis smokers AN - 772262959; 201030342 AB - Background Cannabis withdrawal is not recognized in DSM-IV because of doubts about its clinical significance. Objectives Assess the phenomenon of cannabis withdrawal and its relationship to relapse in non-treatment-seeking adults. Subjects Convenience sample of 469 adult cannabis smokers who had made a quit attempt while not in a controlled environment. Methods Subjects completed a 176-item Marijuana Quit Questionnaire collecting information on sociodemographic characteristics, cannabis use history, and their 'most difficult' cannabis quit attempt. Results 42.4% of subjects had experienced a lifetime withdrawal syndrome, of whom 70.4% reported using cannabis in response to withdrawal. During the index quit attempt, 95.5% of subjects reported >=1 individual withdrawal symptom (mean [SD] 9.5 [6.1], median 9.0); 43.1% reported >=10. Number of withdrawal symptoms was significantly associated with greater frequency and amount of cannabis use, but symptoms occurred even in those using less than weekly. Symptoms were usually of >= moderate intensity and often prompted actions to relieve them. Alcohol (41.5%) and tobacco (48.2%) were used more often than cannabis (33.3%) for this purpose. There was little change during withdrawal in use of other legal or illegal substances. Conclusions Cannabis withdrawal is a common syndrome among adults not seeking treatment. The intention to relieve withdrawal symptoms can drive relapse during quit attempts, giving cannabis withdrawal clinical significance as a target of treatment. [Copyright Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Levin, Kenneth H AU - Copersino, Marc L AU - Heishman, Stephen J AU - Liu, Fang AU - Kelly, Deanna L AU - Boggs, Douglas L AU - Gorelick, David A AD - Intramural Research Program, National Institute on Drug Abuse, 251 Bayview Blvd., Baltimore, MD 21224, USA Y1 - 2010/09/01/ PY - 2010 DA - 2010 Sep 01 SP - 120 EP - 127 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 111 IS - 1-2 SN - 0376-8716, 0376-8716 KW - Cannabis Marijuana Withdrawal Tolerance Relapse KW - Symptoms KW - Relapse KW - Smokers KW - Cannabis KW - Withdrawal symptoms KW - Helpseeking KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/772262959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Cannabis+withdrawal+symptoms+in+non-treatment-seeking+adult+cannabis+smokers&rft.au=Levin%2C+Kenneth+H%3BCopersino%2C+Marc+L%3BHeishman%2C+Stephen+J%3BLiu%2C+Fang%3BKelly%2C+Deanna+L%3BBoggs%2C+Douglas+L%3BGorelick%2C+David+A&rft.aulast=Levin&rft.aufirst=Kenneth&rft.date=2010-09-01&rft.volume=111&rft.issue=1-2&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2010.04.010 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-11-11 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Cannabis; Withdrawal symptoms; Smokers; Symptoms; Relapse; Helpseeking DO - http://dx.doi.org/10.1016/j.drugalcdep.2010.04.010 ER - TY - JOUR T1 - Dynamic imaging reveals that brain-derived neurotrophic factor can independently regulate motility and direction of neuroblasts within the rostral migratory stream AN - 759311076; 13366575 AB - Neuronal precursors generated in the subventricular zone (SVZ) migrate through the rostral migratory stream (RMS) to the olfactory bulb (OB). Although, the mechanisms regulating this migration remain largely unknown. Studies have shown that molecular factors, such as brain-derived neurotrophic factor (BDNF) emanating from the OB, may function as chemoattractants drawing neuroblasts toward their target. To better understand the role of BDNF in RMS migration, we used an acute slice preparation from early postnatal mice to track the tangential migration of GAD65-GFP labeled RMS neuroblasts with confocal time-lapse imaging. By quantifying the cell dynamics using specific directional and motility criteria, our results showed that removal of the OB did not alter the overall directional trajectory of neuroblasts, but did reduce their motility. This suggested that additional guidance factors present locally within the RMS region also contribute to this migration. Here we report that BDNF and its high affinity receptor, tyrosine kinase receptor type 2 (TrkB), are indeed heterogeneously expressed within the RMS at postnatal day 7. By altering BDNF levels within the entire pathway, we showed that reduced BDNF signaling changes both neuroblast motility and direction, while increased BDNF levels changes only motility. Together these data reveal that during this early postnatal period BDNF plays a complex role in regulating both the motility and direction of RMS flow, and that BDNF comes from sources within the RMS itself, as well as from the olfactory bulb. JF - Neuroscience AU - Bagley, JA AU - Belluscio, L AD - Developmental Neural Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA, belluscl@ninds.nih.gov Y1 - 2010/09/01/ PY - 2010 DA - 2010 Sep 01 SP - 1449 EP - 1461 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 169 IS - 3 SN - 0306-4522, 0306-4522 KW - Aqualine Abstracts; Water Resources Abstracts; ASFA 1: Biological Sciences & Living Resources; Animal Behavior Abstracts; CSA Neurosciences Abstracts KW - RMS KW - BDNF KW - SVZ KW - imaging KW - neuroblast KW - motility KW - GAD65 KW - GFP KW - OB KW - TrkB KW - subventricular zone KW - Tyrosine KW - Migration KW - Streams KW - Olfactory bulb KW - Nervous system KW - Cell migration KW - Brain slice preparation KW - Neural stem cells KW - Brain-derived neurotrophic factor KW - Data processing KW - Receptors KW - Mice KW - Protein-tyrosine kinase receptors KW - Dynamics KW - Imaging techniques KW - TrkB receptors KW - Motility KW - Computed tomography KW - Chemotactic factors KW - Neuroblasts KW - Olfaction KW - Signal transduction KW - SW 5010:Network design KW - Q1 08421:Migrations and rhythms KW - AQ 00006:Sewage KW - Y 25080:Orientation, Migration and Locomotion KW - N3 11003:Developmental neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759311076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Dynamic+imaging+reveals+that+brain-derived+neurotrophic+factor+can+independently+regulate+motility+and+direction+of+neuroblasts+within+the+rostral+migratory+stream&rft.au=Bagley%2C+JA%3BBelluscio%2C+L&rft.aulast=Bagley&rft.aufirst=JA&rft.date=2010-09-01&rft.volume=169&rft.issue=3&rft.spage=1449&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/10.1016%2Fj.neuroscience.2010.05.075 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-08-19 N1 - SubjectsTermNotLitGenreText - Receptors; Tyrosine; Imaging techniques; Olfaction; Brain-derived neurotrophic factor; Data processing; subventricular zone; Protein-tyrosine kinase receptors; Olfactory bulb; TrkB receptors; Motility; Nervous system; Chemotactic factors; Computed tomography; Brain slice preparation; Cell migration; Neural stem cells; Neuroblasts; Signal transduction; Mice; Streams; Migration; Dynamics DO - http://dx.doi.org/10.1016/j.neuroscience.2010.05.075 ER - TY - JOUR T1 - Opportunities and barriers to disease prevention counseling in the primary care setting: a multisite qualitative study with US health consumers AN - 758115089; 201029450 AB - The purpose of this study is to understand people's receptivity to seeking out disease prevention counseling from their primary care provider. Since patients' openness to health messages may vary depending on how they seek out their health information, participants were segmented into one of four unique information-seeking groups. This study explores the differences among these groups, what approaches would be most effective in motivating different health consumers to seek out behavioral counseling in the primary care setting and the opportunities during the medical visit most appropriate for this counseling. To this end, a total of 32 focus groups were conducted with American adults. Participants were segmented by information-seeking orientation (independent actives, doctor-dependent actives, independent passives and doctor-dependent passives), age and gender. Findings showed that participants of the four information-seeking groups possessed distinct differences in their desire for and perceived barriers to requesting counseling from their provider. Overall, participants wanted prevention counseling to include tailored information, encouragement and follow-up. Participants among the various segments identified two key windows of opportunity-during a routine checkup and when discussing their family history-where patients and providers can incorporate more in-depth prevention discussions into the medical visit. Findings from this study suggest that targeting health messages according to health consumers' information-seeking orientations may provide an effective tool for practitioners. Additionally, many health consumers are open to behavioral counseling in the primary care setting and would be satisfied if this counseling were integrated into traditional procedures, such as during a routine checkup or when discussing their family medical history. Adapted from the source document. JF - Health Promotion International AU - Wolff, Lisa S AU - Massett, Holly A AU - Weber, Deanne AU - Mockenhaupt, Robin E AU - Hassmiller, Susan AU - Maibach, Edward W AD - Research and Evaluation Department, Health Resources in Action, 95 Berkeley Street, Boston, MA 02116, USA, Office of Market Research and Evaluation, National Cancer Institute, National Institutes of Health, Rockville, MD, USA, Strategic Planning and Research, Porter Novelli, Washington, DC, USA, Health Group, Robert Wood Johnson Foundation, Princeton, NJ, USA Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 265 EP - 276 PB - Oxford University Press, UK VL - 25 IS - 3 SN - 0957-4824, 0957-4824 KW - Prevention KW - Information seeking KW - Counselling KW - Primary health care KW - Consumers KW - Health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758115089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Promotion+International&rft.atitle=Opportunities+and+barriers+to+disease+prevention+counseling+in+the+primary+care+setting%3A+a+multisite+qualitative+study+with+US+health+consumers&rft.au=Wolff%2C+Lisa+S%3BMassett%2C+Holly+A%3BWeber%2C+Deanne%3BMockenhaupt%2C+Robin+E%3BHassmiller%2C+Susan%3BMaibach%2C+Edward+W&rft.aulast=Wolff&rft.aufirst=Lisa&rft.date=2010-09-01&rft.volume=25&rft.issue=3&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Health+Promotion+International&rft.issn=09574824&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - HPINET N1 - SubjectsTermNotLitGenreText - Counselling; Health; Primary health care; Prevention; Information seeking; Consumers ER - TY - JOUR T1 - High Neuroticism and low Conscientiousness are associated with interleukin-6 AN - 758114987; 201029221 AB - High Neuroticism and low Conscientiousness are frequently implicated in health-risk behaviors, such as smoking and overeating, as well as health outcomes, including mortality. Their associations with physiological markers of morbidity and mortality, such as inflammation, are less well documented. The present research examines the association between the five major dimensions of personality and interleukin-6 (IL-6), a pro-inflammatory cytokine often elevated in patients with chronic morbidity and frailty. A population-based sample (n=4923) from four towns in Sardinia, Italy, had their levels of IL-6 measured and completed a comprehensive personality questionnaire, the NEO-PI-R. Analyses controlled for factors known to have an effect on IL-6: age; sex; smoking; weight; aspirin use; disease burden. High Neuroticism and low Conscientiousness were both associated with higher levels of IL-6. The findings remained significant after controlling for the relevant covariates. Similar results were found for C-reactive protein, a related marker of chronic inflammation. Further, smoking and weight partially mediated the association between impulsivity-related traits and higher IL-6 levels. Finally, logistic regressions revealed that participants either in the top 10% of the distribution of Neuroticism or the bottom 10% of conscientiousness had an approximately 40% greater risk of exceeding clinically relevant thresholds of IL-6. Consistent with the literature on personality and self-reported health, individuals high on Neuroticism or low on Conscientiousness show elevated levels of this inflammatory cytokine. Identifying critical medical biomarkers associated with personality may help to elucidate the physiological mechanisms responsible for the observed connections between personality traits and physical health. Adapted from the source document. JF - Psychological Medicine AU - Sutin, A R AU - Terracciano, A AU - Deiana, B AU - Naitza, S AU - Ferrucci, L AU - Uda, M AU - Schlessinger, D AU - Costa, P T AD - National Institute on Aging, NIH, DHHS, USA sutina@mail.nih.gov Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 1485 EP - 1493 PB - Cambridge University Press, UK VL - 40 IS - 9 SN - 0033-2917, 0033-2917 KW - Smoking KW - Neuroticism KW - Personality KW - Conscientiousness KW - Inflammation KW - Morbidity-Mortality KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758114987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=High+Neuroticism+and+low+Conscientiousness+are+associated+with+interleukin-6&rft.au=Sutin%2C+A+R%3BTerracciano%2C+A%3BDeiana%2C+B%3BNaitza%2C+S%3BFerrucci%2C+L%3BUda%2C+M%3BSchlessinger%2C+D%3BCosta%2C+P+T&rft.aulast=Sutin&rft.aufirst=A&rft.date=2010-09-01&rft.volume=40&rft.issue=9&rft.spage=1485&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291709992029 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Neuroticism; Personality; Conscientiousness; Morbidity-Mortality; Smoking; Inflammation DO - http://dx.doi.org/10.1017/S0033291709992029 ER - TY - JOUR T1 - Commentary on "Mapping Health Communication Scholarship: Breadth, Depth, and Agenda of Published Research in Health Communication": Implications for Reaching Practitioners With Communication Research AN - 758111468; 201028763 AB - Abstract not available. JF - Health Communication AU - Nelson, David E AD - Cancer Prevention Fellowship Program, National Cancer Institute Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 542 EP - 543 PB - Taylor & Francis Group, Philadelphia PA VL - 25 IS - 6-7 SN - 1041-0236, 1041-0236 KW - Medical research KW - Health education KW - Mapping KW - Health information KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758111468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Communication&rft.atitle=Commentary+on+%22Mapping+Health+Communication+Scholarship%3A+Breadth%2C+Depth%2C+and+Agenda+of+Published+Research+in+Health+Communication%22%3A+Implications+for+Reaching+Practitioners+With+Communication+Research&rft.au=Nelson%2C+David+E&rft.aulast=Nelson&rft.aufirst=David&rft.date=2010-09-01&rft.volume=25&rft.issue=6-7&rft.spage=542&rft.isbn=&rft.btitle=&rft.title=Health+Communication&rft.issn=10410236&rft_id=info:doi/10.1080%2F10410236.2010.497916 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - HECOER N1 - SubjectsTermNotLitGenreText - Health education; Medical research; Health information; Mapping DO - http://dx.doi.org/10.1080/10410236.2010.497916 ER - TY - JOUR T1 - Continuing Education: Direct-to-Consumer Genetic and Genomic Testing: Preparing Nurse Practitioners for Genomic Healthcare AN - 758110649; 201028544 AB - Rapidly emerging technologies make it possible for consumers to acquire information that is intended to explain their inherited susceptibility to disease and facilitate tailored healthcare services through direct-to-consumer (DTC) marketing of personal genetic (PG) and personal genomic (PGM) testing. However, the health benefits and risks associated with these technologies are largely unknown. Consumers will turn to their healthcare providers, including nurse practitioners, to interpret test results and seek guidance on how to use these test results for medical decision-making. Nurse practitioners will need to constantly update their practice skills in response to advances in genomic technology that create new expectations among patients and lead to substantial changes in healthcare delivery. [Copyright Elsevier B.V.] JF - The Journal for Nurse Practitioners AU - Loud, Jennifer T Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 585 EP - 594 PB - Elsevier Ltd, The Netherlands VL - 6 IS - 8 SN - 1555-4155, 1555-4155 KW - direct-to-consumer marketing nurse practitioner personal genetic testing personal genomic testing KW - Health care KW - Care delivery KW - Guidance KW - Genetic screening KW - Information technology KW - Consumers KW - Nurse practitioners KW - Continuing education KW - Technology KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758110649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+for+Nurse+Practitioners&rft.atitle=Continuing+Education%3A+Direct-to-Consumer+Genetic+and+Genomic+Testing%3A+Preparing+Nurse+Practitioners+for+Genomic+Healthcare&rft.au=Loud%2C+Jennifer+T&rft.aulast=Loud&rft.aufirst=Jennifer&rft.date=2010-09-01&rft.volume=6&rft.issue=8&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=The+Journal+for+Nurse+Practitioners&rft.issn=15554155&rft_id=info:doi/10.1016%2Fj.nurpra.2010.06.007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nurse practitioners; Health care; Consumers; Technology; Guidance; Continuing education; Information technology; Care delivery; Genetic screening DO - http://dx.doi.org/10.1016/j.nurpra.2010.06.007 ER - TY - JOUR T1 - Dissociative Disorders in a Psychiatric Institute in India - A Selected Review and Patterns Over a Decade AN - 758109409; 201027706 AB - Background: The prevalence -- and type -- of dissociative disorders is considered to vary across cultures and over time. Aims: The aim of the study was to examine patterns of dissociative disorders among subjects attending psychiatric services over a period of 10 years. Methods: The sample consisted of both inpatients and outpatients attending a psychiatric hospital between 1999 and 2008. Information of those subjects diagnosed to have dissociative disorders was reviewed. A semi-structured proforma was used to collect information about demographic details and diagnosis. Results: A total of 893 patients had been diagnosed with dissociative disorder over the past decade: 591 (66%) were outpatients and 302 (34%) were inpatients. The proportion of patients diagnosed with dissociative disorders ranged between 1.5 and 15.0 per 1,000 for outpatients and between 1.5 and 11.6 per 1,000 for inpatients. The majority of patients were diagnosed with dissociative motor disorder (43.3% outpatients, 37.7% inpatients), followed by dissociative convulsions (23% outpatients, 27.8% inpatients). Female preponderance was seen across all sub-types of dissociative disorder except dissociative fugue. Conclusions: Dissociative disorders are still commonly diagnosed in both inpatient and outpatient settings. Dissociative motor disorders and dissociative convulsions are the most common disorders. Unlike in the West, dissociative identity disorders were rarely diagnosed; instead, possession states were commonly seen in the Indian population, indicating cross-cultural disparity. [Reprinted by permission of Sage Publications Ltd., copyright holder.] JF - International Journal of Social Psychiatry AU - Chaturvedi, Santosh K AU - Desai, Geetha AU - Shaligram, Deepika AD - Department of Psychiatry, National Institute of Mental Health and Neurosciences, NIMHANS, Bangalore, India Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 533 EP - 539 PB - Sage Publications, London UK VL - 56 IS - 5 SN - 0020-7640, 0020-7640 KW - dissociative disorders patterns India possession states KW - Outpatients KW - Hospitalization KW - Psychiatric hospitals KW - Convulsions KW - Dissociative disorders KW - Prevalence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758109409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Social+Psychiatry&rft.atitle=Dissociative+Disorders+in+a+Psychiatric+Institute+in+India+-+A+Selected+Review+and+Patterns+Over+a+Decade&rft.au=Chaturvedi%2C+Santosh+K%3BDesai%2C+Geetha%3BShaligram%2C+Deepika&rft.aulast=Chaturvedi&rft.aufirst=Santosh&rft.date=2010-09-01&rft.volume=56&rft.issue=5&rft.spage=533&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Social+Psychiatry&rft.issn=00207640&rft_id=info:doi/10.1177%2F0020764009347335 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - IJSPAG N1 - SubjectsTermNotLitGenreText - Dissociative disorders; Hospitalization; Outpatients; Convulsions; Psychiatric hospitals; Prevalence DO - http://dx.doi.org/10.1177/0020764009347335 ER - TY - JOUR T1 - Mammography Decision Making in Older Women With a Breast Cancer Family History AN - 758109391; 201028078 AB - Purpose: This study's purpose is to describe and explain how women 55 years of age and older with a family history of breast cancer make screening mammography decisions. qualitative design based on grounded theory. This purposeful sample consisted of 23 women 55 years of age or older with one more first-degree relatives diagnosed with breast cancer.Method: Open-ended interviews were conducted with 23 women 55 years of age and older with a family history of breast cancer using a semistructured interview guide. Transcribed interview data were analyzed using constant comparative analysis to identify the conditions, actions, and consequences associated with participant's screening mammography decision making. becoming aware of their breast cancer risk usually due to a triggering event such as having a family member diagnosed with breast cancer, resulting in women 'guarding against cancer.' Women's actions included having mammograms, getting health check-ups, having healthy behaviors, and being optimistic. Most women reported extraordinary faith in mammography, often ignoring negative mammogram information. A negative mammogram gave women peace of mind and assurance that breast cancer was not present. Being called back for additional mammograms caused worry, especially with delayed results.Conclusions: The 'guarding against cancer' theory needs to be tested in other at-risk populations and ultimately used to test strategies that promote cancer screening decision making and the adoption of screening behaviors in those at increased risk for developing cancer. 55 years of age and older with a breast cancer family history need timely mammogram results, mammography reminders, and psychosocial support when undergoing a mammography recall or other follow-up tests. Adapted from the source document. JF - Journal of Nursing Scholarship AU - Greco, Karen E AU - Nail, Lillian M AU - Kendall, Judy AU - Cartwright, Juliana AU - Messecar, Deborah C AD - Beta Psi, Nurse Specialist (research), Contractor, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 348 EP - 356 PB - Wiley-Blackwell, UK VL - 42 IS - 3 SN - 1527-6546, 1527-6546 KW - Mammography decision making breast cancer screening breast screening breast cancer family history grounded theory qualitative research KW - Decision making KW - Mammography KW - Family histories KW - Women KW - Breast cancer KW - Relatives KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758109391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nursing+Scholarship&rft.atitle=Mammography+Decision+Making+in+Older+Women+With+a+Breast+Cancer+Family+History&rft.au=Greco%2C+Karen+E%3BNail%2C+Lillian+M%3BKendall%2C+Judy%3BCartwright%2C+Juliana%3BMessecar%2C+Deborah+C&rft.aulast=Greco&rft.aufirst=Karen&rft.date=2010-09-01&rft.volume=42&rft.issue=3&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nursing+Scholarship&rft.issn=15276546&rft_id=info:doi/10.1111%2Fj.1547-5069.2010.01335.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Breast cancer; Mammography; Women; Family histories; Decision making; Relatives DO - http://dx.doi.org/10.1111/j.1547-5069.2010.01335.x ER - TY - JOUR T1 - Frequency of 5+/4+ Drinks as a Screener for Drug Use and Drug-Use Disorders AN - 758108437; 201027802 AB - Objective: The objective of this study was to test the ability of a question on frequency of drinking 5+ (for men) or 4+ (for women) drinks to screen for drug use and drug-use disorders (DUDs) in a general population sample. Method: Using data collected in 2001-2002 from a representative U.S. adult population sample (N = 43,093), including a subsample of those with past-year emergency-department use (n = 8,525), past-year frequency of drinking 5+/4+ drinks was evaluated as a screener for drug use and DUDs for four categories of illicit drags. Results: Sensitivities and specificities of the 5+/4+ drinks screener were 72.4% and 76.6% for any drag dependence, 71.9% and 77.3% for any DUD, and 63.3% and 78.9% for any drag use in the general population. Sensitivities and specificities were higher for marijuana and cocaine/crack and lowest for illicit prescription drugs. Optimal screening cut-points were once a month or more for cocaine/crack dependence, either once or more a month or seven or more times a year for cocaine/crack DUDs, seven or more times a year for cocaine/crack use, and once or more a year for the other drag use and DUD measures. Sensitivity and specificity were similar among adults who had visited an emergency department in the past year, and the optimal screening cutpoints were identical. Conclusions: Past-year frequency of drinking 5+/4+ drinks was quite accurate as a screener for past-year marijuana and cocaine/crack use and DUDs, but it was less accurate for illicit prescription drag use and DUDs. Its drag-screening potential can be thought of as "added value" from an item already likely to be asked in the interest of detecting problem drinking. Future work may consider using the alcohol consumption screener as a starting point, with follow-up questions to assess illicit drag use among those who screen positive. Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - Dawson, Deborah A AU - Compton, Wilson M AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, National Institute on Alcohol Abuse and Alcoholism, 5635 Fishers Lane, MSC 9304, Bethesda, Maryland 20892-9304 ddawson@mail.nih.gov Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 751 EP - 760 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 71 IS - 5 SN - 1937-1888, 1937-1888 KW - Alcohol consumption KW - Sensitivity KW - Drinks KW - Crack KW - Cannabis KW - Drug abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758108437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=Frequency+of+5%2B%2F4%2B+Drinks+as+a+Screener+for+Drug+Use+and+Drug-Use+Disorders&rft.au=Dawson%2C+Deborah+A%3BCompton%2C+Wilson+M%3BGrant%2C+Bridget+F&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2010-09-01&rft.volume=71&rft.issue=5&rft.spage=751&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Crack; Alcohol consumption; Sensitivity; Drug abuse; Drinks; Cannabis ER - TY - JOUR T1 - Effects of synthetic androgens on liver function using the rabbit as a model. AN - 756823510; 20378929 AB - The objective of this study was to determine whether the rabbit was a suitable model to test new synthetic androgens for potential liver toxicity within a short dosing interval. Adult male rabbits were dosed orally daily on days 0-13 with 17α-methyltestosterone (MT) as a positive control and testosterone (T) as a negative control to validate this model. Synthetic androgens tested were: 7α-methyl-19-nortestosterone (MENT), dimethandrolone-undecanoate (DMAU), and 11β-methyl-19-nortestosterone-17β-dodecylcarbonate (11β-MNTDC). Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transpeptidase (GGT), and sorbitol dehydrogenase (SDH), as well as clearance of intravenous injected bromsulfonphthalein (BSP) from serum on days 0, 7, and 14, were determined. As expected, T (10 mg/kg/d) did not adversely affect BSP retention or serum liver enzymes. MT (10 mg/kg/d) increased BSP retention, and AST, ALT, GGT, and SDH levels, indicating that this model could detect androgens known to be hepatotoxic. DMAU and MENT (10 mg/kg/d) increased BSP retention and all 4 serum liver enzymes as well, but the effects were less than those observed with MT at the same dose. All parameters returned to baseline 2 weeks after cessation of dosing. 11β-MNTDC at 10 mg/kg/d did not have an effect on BSP retention or liver enzymes, but a slight increase in serum GGT levels was observed in rabbits treated with 25 mg/kg/d. For the androgens that exhibited liver toxicity at 10 mg/kg/d (MT, DMAU, and MENT), a no-observed-effect level of 1 mg/kg/d was established. Overall ranking of the synthetic androgens from most to least hepatotoxic on the basis of percent BSP retention was: MT & DMAU > MENT > 11β-MNTDC. Hence, the rabbit appears to be a promising model for detection of potential liver toxicity by synthetic androgens using BSP clearance and serum liver enzyme levels as early indicators of injury. JF - Journal of andrology AU - Hild, Sheri Ann AU - Attardi, Barbara J AU - Koduri, Sailaja AU - Till, Bruce A AU - Reel, Jerry R AD - BIOQUAL Inc, Division of Reproductive Endocrinology and Toxicology, Rockville, Maryland, USA. hildsa@mail.nih.gov PY - 2010 SP - 472 EP - 481 VL - 31 IS - 5 KW - 11-methyl-19-nortestosterone-17-dodecylcarbonate KW - 0 KW - Testosterone Congeners KW - dimethandrolone-undecanoate KW - Sulfobromophthalein KW - 0C2P5QKL36 KW - Testosterone KW - 3XMK78S47O KW - trestolone KW - 40P3287I94 KW - Nandrolone KW - 6PG9VR430D KW - L-Iditol 2-Dehydrogenase KW - EC 1.1.1.14 KW - gamma-Glutamyltransferase KW - EC 2.3.2.2 KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Methyltestosterone KW - V9EFU16ZIF KW - Index Medicus KW - Animals KW - Nandrolone -- analogs & derivatives KW - Nandrolone -- pharmacology KW - Rabbits KW - Aspartate Aminotransferases -- blood KW - Alanine Transaminase -- blood KW - No-Observed-Adverse-Effect Level KW - Testosterone -- pharmacology KW - L-Iditol 2-Dehydrogenase -- blood KW - Methyltestosterone -- pharmacology KW - gamma-Glutamyltransferase -- blood KW - Male KW - Liver -- drug effects KW - Testosterone Congeners -- pharmacology KW - Liver -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756823510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+andrology&rft.atitle=Effects+of+synthetic+androgens+on+liver+function+using+the+rabbit+as+a+model.&rft.au=Hild%2C+Sheri+Ann%3BAttardi%2C+Barbara+J%3BKoduri%2C+Sailaja%3BTill%2C+Bruce+A%3BReel%2C+Jerry+R&rft.aulast=Hild&rft.aufirst=Sheri&rft.date=2010-09-01&rft.volume=31&rft.issue=5&rft.spage=472&rft.isbn=&rft.btitle=&rft.title=Journal+of+andrology&rft.issn=1939-4640&rft_id=info:doi/10.2164%2Fjandrol.109.009365 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-24 N1 - Date created - 2010-10-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Dig Dis. 1965 Feb;10:147-51 [14258250] Proc Soc Exp Biol Med. 1963 Aug-Sep;113:1006-8 [14073093] Proc Soc Exp Biol Med. 1956 Apr;91(4):569-71 [13323003] Pharmacol Ther. 2006 Jan;109(1-2):1-11 [16085315] Endocrinology. 2006 Jun;147(6):3016-26 [16497801] Liver Int. 2007 Oct;27(8):1144-7 [17845544] Liver Int. 2008 Feb;28(2):278-82 [17900246] Clin Toxicol (Phila). 2008 Jan;46(1):57-66 [17852158] Drug Metab Dispos. 2008 Jun;36(6):1111-8 [18347083] J Appl Toxicol. 2008 Jul;28(5):703-9 [18059068] J Histochem Cytochem. 2009 May;57(5):449-56 [19153193] Nephron Physiol. 2010;114(4):p35-40 [20110735] Acta Endocrinol (Copenh). 1975 Aug;79(4):789-800 [1173974] Hum Reprod. 2000 May;15(5):1100-6 [10783360] Int J Androl. 2000;23 Suppl 2:13-5 [10849485] Toxicol Sci. 2002 Oct;69(2):460-9 [12377995] Am J Med. 1965 Nov;39(5):849-54 [5833579] J Clin Endocrinol Metab. 1971 Dec;33(6):988-91 [5316354] Toxicology. 1977 Jun;7(3):357-65 [888151] Int Arch Occup Environ Health. 1982;51(1):73-9 [7152704] Fundam Appl Toxicol. 1981 Jul-Aug;1(4):329-33 [6136444] J Pathol. 1984 Jul;143(3):211-8 [6747751] Semin Liver Dis. 1987 Aug;7(3):230-6 [3317860] Arch Intern Med. 1989 Sep;149(9):2127-9 [2774790] Hepatology. 1995 May;21(5):1387-94 [7737646] J Pharmacol Toxicol Methods. 1995 Aug;33(4):187-95 [8527826] Chem Biol Interact. 1999 Jun 1;121(1):17-35 [10418968] J Clin Invest. 1955 Jan;34(1):126-31 [13221663] Ann Intern Med. 1956 Nov;45(5):801-11 [13373188] Tech Bull Regist Med Technol. 1959 Jul;29(7):117-9 [13668904] Arch Intern Med. 1965 Aug;116:289-94 [14315662] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2164/jandrol.109.009365 ER - TY - JOUR T1 - Rapid vision loss associated with fludarabine administration. AN - 755175838; 20224467 AB - The purpose of this study was to report the clinical and pathologic findings of three cases of rapid vision loss associated with fludarabine toxicity. A retrospective, single-center case series was conducted. Autopsies of the eyes from three cases were performed. A 23-year-old man (Case 1) with systemic lupus erythematosus developed rapid and severe vision loss, generalized neurologic decline, and eventual death after administration of fludarabine before stem cell transplantation. A 48-year-old woman (Case 2) and a 60-year-old man (Case 3), both with metastatic melanoma, had similar courses after receiving fludarabine as part of a preparatory regimen before adoptive cell therapy. Fundus examination showed punctuate yellow flecks in the macula after visual decline in two cases. In all three cases, serum antiretinal antibodies were negative before and after treatment; electrophysiological testing showed markedly decreased B-waves; and pathologic analysis showed loss of retinal bipolar and ganglion cells, gliosis within the retina and optic nerve, and optic nerve atrophy. Fludarabine toxicity can result in severe vision loss attributable to damage to retinal bipolar and ganglion cells. Although effective treatments are not known, care should be taken to consider fludarabine toxicity in patients who present with vision loss approximately 1 month after treatment. JF - Retina (Philadelphia, Pa.) AU - Bishop, Rachel J AU - Ding, Xiaoyan AU - Heller, Charles K AU - Illei, Gabor AU - Caruso, Rafael C AU - Cunningham, Denise AU - Pavletic, Steven AU - Chan, Chi-Chao AD - National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA. bishopra@nei.nih.gov Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 1272 EP - 1277 VL - 30 IS - 8 KW - Antineoplastic Agents KW - 0 KW - Myeloablative Agonists KW - Vidarabine KW - FA2DM6879K KW - fludarabine KW - P2K93U8740 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Young Adult KW - Fatal Outcome KW - Retina -- drug effects KW - Humans KW - Melanoma -- secondary KW - Retrospective Studies KW - Brain Diseases -- diagnosis KW - Myeloablative Agonists -- adverse effects KW - Evoked Potentials, Visual KW - Lupus Erythematosus, Systemic -- drug therapy KW - Retina -- physiopathology KW - Brain Diseases -- chemically induced KW - Melanoma -- drug therapy KW - Middle Aged KW - Female KW - Male KW - Electroretinography KW - Vidarabine -- analogs & derivatives KW - Retinal Diseases -- diagnosis KW - Blindness -- physiopathology KW - Vidarabine -- adverse effects KW - Retinal Diseases -- chemically induced KW - Blindness -- chemically induced KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755175838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Retina+%28Philadelphia%2C+Pa.%29&rft.atitle=Rapid+vision+loss+associated+with+fludarabine+administration.&rft.au=Bishop%2C+Rachel+J%3BDing%2C+Xiaoyan%3BHeller%2C+Charles+K%3BIllei%2C+Gabor%3BCaruso%2C+Rafael+C%3BCunningham%2C+Denise%3BPavletic%2C+Steven%3BChan%2C+Chi-Chao&rft.aulast=Bishop&rft.aufirst=Rachel&rft.date=2010-09-01&rft.volume=30&rft.issue=8&rft.spage=1272&rft.isbn=&rft.btitle=&rft.title=Retina+%28Philadelphia%2C+Pa.%29&rft.issn=1539-2864&rft_id=info:doi/10.1097%2FIAE.0b013e3181d20589 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-29 N1 - Date created - 2010-09-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Treat Rep. 1986 Oct;70(10):1225-8 [2428492] Cancer Res. 1986 Nov;46(11):5953-8 [2428488] J Clin Oncol. 1986 Jan;4(1):74-9 [2416889] Cancer. 2004 Apr 1;100(7):1438-48 [15042678] J Clin Oncol. 1994 Oct;12(10):2216-28 [7931492] J Clin Oncol. 2007 Mar 1;25(7):793-8 [17283364] Cancer Invest. 1990;8(5):459-65 [2124943] Ophthalmology. 2004 Mar;111(3):535-9 [15019332] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/IAE.0b013e3181d20589 ER - TY - JOUR T1 - Structure and Function Analysis of Therapeutic Monoclonal Antibodies against Dengue Virus Type 2 AN - 755132261; 13628183 AB - Dengue virus (DENV) is the most prevalent insect-transmitted viral disease in humans globally, and currently no specific therapy or vaccine is available. Protection against DENV and other related flaviviruses is associated with the development of antibodies against the viral envelope (E) protein. Although prior studies have characterized the neutralizing activity of monoclonal antibodies (MAbs) against DENV type 2 (DENV-2), none have compared simultaneously the inhibitory activity against a genetically diverse range of strains in vitro, the protective capacity in animals, and the localization of epitopes. Here, with the goal of identifying MAbs that can serve as postexposure therapy, we investigated in detail the functional activity of a large panel of new anti-DENV-2 mouse MAbs. Binding sites were mapped by yeast surface display and neutralization escape, cell culture inhibition assays were performed with homologous and heterologous strains, and prophylactic and therapeutic activity was evaluated with two mouse models. Protective MAbs localized to epitopes on the lateral ridge of domain I (DI), the dimer interface, lateral ridge, and fusion loop of DII, and the lateral ridge, C-C' loop, and A strand of DIII. Several MAbs inefficiently inhibited at least one DENV-2 strain of a distinct genotype, suggesting that recognition of neutralizing epitopes varies with strain diversity. Moreover, antibody potency generally correlated with a narrowed genotype and serotype specificity. Five MAbs functioned efficiently as postexposure therapy when administered as a single dose, even 3 days after intracranial infection of BALB/c mice. Overall, these studies define the structural and functional complexity of antibodies against DENV-2 with protective potential. JF - Journal of Virology AU - Sukupolvi-Petty, Soila AU - Austin, SKyle AU - Engle, Michael AU - Brien, James D AU - Dowd, Kimberly A AU - Williams, Katherine L AU - Johnson, Syd AU - Rico-Hesse, Rebeca AU - Harris, Eva AU - Pierson, Theodore C AD - Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland, diamond@borcim.wustl.edu Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 9227 EP - 9239 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 84 IS - 18 SN - 0022-538X, 0022-538X KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Virology & AIDS Abstracts KW - Human diseases KW - Serotypes KW - Monoclonal antibodies KW - Animal models KW - Therapy KW - Cell culture KW - Genotypes KW - Infection KW - Public health KW - Antibodies KW - Envelopes KW - Viral diseases KW - Structure-function relationships KW - Envelope protein KW - Vaccines KW - Dengue virus type 2 KW - Epitopes KW - V 22410:Animal Diseases KW - Q1 08423:Behaviour KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755132261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Structure+and+Function+Analysis+of+Therapeutic+Monoclonal+Antibodies+against+Dengue+Virus+Type+2&rft.au=Sukupolvi-Petty%2C+Soila%3BAustin%2C+SKyle%3BEngle%2C+Michael%3BBrien%2C+James+D%3BDowd%2C+Kimberly+A%3BWilliams%2C+Katherine+L%3BJohnson%2C+Syd%3BRico-Hesse%2C+Rebeca%3BHarris%2C+Eva%3BPierson%2C+Theodore+C&rft.aulast=Sukupolvi-Petty&rft.aufirst=Soila&rft.date=2010-09-01&rft.volume=84&rft.issue=18&rft.spage=9227&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.01087-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Number of references - 73 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Human diseases; Antibodies; Viral diseases; Monoclonal antibodies; Therapy; Vaccines; Genotypes; Public health; Envelopes; Serotypes; Structure-function relationships; Envelope protein; Animal models; Cell culture; Infection; Epitopes; Dengue virus type 2 DO - http://dx.doi.org/10.1128/JVI.01087-10 ER - TY - JOUR T1 - Lessons from models of pancreatic b cells for engineering glucose-sensing cells AN - 754896080; 13526578 AB - Mathematical models of pancreatic b cells suggest design principles that can be applied to engineering cells to sense glucose and secrete insulin. Engineering cells can potentially both contribute to future diabetes therapies and generate new insights into b-cell function. The focus is on ion channels, Ca super(2+) handling, and elements of metabolism that combine to produce the varied oscillatory patterns exhibited by b cells. JF - Mathematical Biosciences AU - Sherman, Arthur AD - National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Laboratory of Biological Modeling, 12A South Drive, Room 4007, Bethesda, MD 20892-5621, USA, asherman@nih.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 12 EP - 19 PB - Elsevier Science, Box 882 New York NY 10159 USA VL - 227 IS - 1 SN - 0025-5564, 0025-5564 KW - Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Diabetes mellitus KW - Mathematical models KW - Pancreas KW - Ion channels KW - Glucose KW - Calcium channels KW - Beta cells KW - Metabolism KW - Insulin KW - W 30910:Imaging KW - T 2000:Cellular Calcium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754896080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mathematical+Biosciences&rft.atitle=Lessons+from+models+of+pancreatic+b+cells+for+engineering+glucose-sensing+cells&rft.au=Sherman%2C+Arthur&rft.aulast=Sherman&rft.aufirst=Arthur&rft.date=2010-09-01&rft.volume=227&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Mathematical+Biosciences&rft.issn=00255564&rft_id=info:doi/10.1016%2Fj.mbs.2010.05.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Mathematical models; Pancreas; Ion channels; Calcium channels; Glucose; Beta cells; Insulin; Metabolism DO - http://dx.doi.org/10.1016/j.mbs.2010.05.005 ER - TY - JOUR T1 - Phylogenetic Analysis of Chlamydia trachomatis Tarp and Correlation with Clinical Phenotype AN - 754895431; 13527191 AB - Chlamydia trachomatis is the leading cause of infectious blindness worldwide and is the most commonly reported pathogen causing sexually transmitted infections. Tarp (translocated actin recruiting phosphoprotein), a type III secreted effector that mediates actin nucleation, is central to C. trachomatis infection. The phylogenetic analysis of tarP from reference strains as well as ocular, genital, and lymphogranuloma venereum (LGV) clinical isolates demonstrated an evolutionary relationship with disease phenotype, with LGV and ocular isolates branched into clades that were separate from the urogenital isolates. The sequence analysis of Tarp indicated a high degree of variability and identified trends within clinical groupings. Tarps from LGV strains contained the highest number of tyrosine-rich repeat regions (up to nine) and the fewest (two) predicted actin binding domains. The converse was noted for Tarp proteins from ocular isolates that contained up to four actin binding domains and as few as one tyrosine-rich repeat region. The results suggest that Tarp is among the few known genes to play a role in C. trachomatis adaptations to specific niches within the host. JF - Infection and Immunity AU - Lutter, Erika I AU - Bonner, Christine AU - Holland, Martin J AU - Suchland, Robert J AU - Stamm, Walter E AU - Jewett, Travis J AU - McClarty, Grant AU - Hackstadt, Ted AD - Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, Ted_Hackstadt@NIH.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 3678 EP - 3688 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 78 IS - 9 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Phylogeny KW - Clinical isolates KW - Adaptations KW - Niches KW - Lymphogranuloma venereum KW - Chlamydia trachomatis KW - Pathogens KW - Blindness KW - Infection KW - Nucleation KW - Phosphoproteins KW - Actin KW - Evolution KW - J 02310:Genetics & Taxonomy KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754895431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Phylogenetic+Analysis+of+Chlamydia+trachomatis+Tarp+and+Correlation+with+Clinical+Phenotype&rft.au=Lutter%2C+Erika+I%3BBonner%2C+Christine%3BHolland%2C+Martin+J%3BSuchland%2C+Robert+J%3BStamm%2C+Walter+E%3BJewett%2C+Travis+J%3BMcClarty%2C+Grant%3BHackstadt%2C+Ted&rft.aulast=Lutter&rft.aufirst=Erika&rft.date=2010-09-01&rft.volume=78&rft.issue=9&rft.spage=3678&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00515-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Nucleation; Phylogeny; Adaptations; Phosphoproteins; Niches; Lymphogranuloma venereum; Actin; Blindness; Pathogens; Infection; Evolution; Chlamydia trachomatis DO - http://dx.doi.org/10.1128/IAI.00515-10 ER - TY - JOUR T1 - Translational considerations for cancer nanomedicine AN - 754894885; 13524946 AB - There are many important considerations during preclinical development of cancer nanomedicines, including: 1) unique aspects of animal study design; 2) the difficulties in evaluating biological potency, especially for complex formulations; 3) the importance of analytical methods that can determine platform stability in vivo, and differentiate bound and free active pharmaceutical ingredient (API) in biological matrices; and 4) the appropriateness of current dose scaling techniques for estimation of clinical first-in-man dose from preclinical data. Biologics share many commonalities with nanotechnology products with regard to complexity and biological attributes, and can, in some cases, provide context for dealing with these preclinical issues. In other instances, such as the case of in vivo stability analysis, new approaches are required. This paper will discuss the significance of these preclinical issues, and present examples of current methods and best practices for addressing them. Where possible, these recommendations are justified using the existing regulatory guidance literature. JF - Journal of Controlled Release AU - Stern, Stephan T AU - Hall, Jennifer B AU - Yu, Lee L AU - Wood, Laura J AU - Paciotti, Giulio F AU - Tamarkin, Lawrence AU - Long, Stephen E AU - McNeil, Scott E AD - Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, PO Box B, Frederick, MD 21702, USA, sternstephan@mail.nih.govhalljennifer@mail.nih.govlee.yu@nist.govlaura.wood@nist.govgpaciotti@cytimmune.comltamarkin@cytimune.comstephen.long@nist.govncl@mail.nih.gov Y1 - 2010/09/01/ PY - 2010 DA - 2010 Sep 01 SP - 164 EP - 174 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 146 IS - 2 SN - 0168-3659, 0168-3659 KW - Biotechnology and Bioengineering Abstracts KW - Translation KW - Data processing KW - Pharmaceuticals KW - Scaling KW - Controlled release KW - Cancer KW - nanotechnology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754894885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Controlled+Release&rft.atitle=Translational+considerations+for+cancer+nanomedicine&rft.au=Stern%2C+Stephan+T%3BHall%2C+Jennifer+B%3BYu%2C+Lee+L%3BWood%2C+Laura+J%3BPaciotti%2C+Giulio+F%3BTamarkin%2C+Lawrence%3BLong%2C+Stephen+E%3BMcNeil%2C+Scott+E&rft.aulast=Stern&rft.aufirst=Stephan&rft.date=2010-09-01&rft.volume=146&rft.issue=2&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Journal+of+Controlled+Release&rft.issn=01683659&rft_id=info:doi/10.1016%2Fj.jconrel.2010.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Translation; Data processing; Pharmaceuticals; Controlled release; Scaling; Cancer; nanotechnology DO - http://dx.doi.org/10.1016/j.jconrel.2010.04.008 ER - TY - JOUR T1 - Frameshift Mutations in a Single Novel Virulence Factor Alter the In Vivo Pathogenicity of Chlamydia trachomatis for the Female Murine Genital Tract , ,|| AN - 754894047; 13527183 AB - Chlamydia trachomatis is a human pathogen of global importance. An obstacle to studying the pathophysiology of human chlamydial disease is the lack of a suitable murine model of C. trachomatis infection. Mice are less susceptible to infection with human isolates due in part to innate mouse-specific host defense mechanisms to which human strains are sensitive. Another possible factor that influences the susceptibility of mice to infection is that human isolates are commonly cultivated in vitro prior to infection of mice; therefore, virulence genes could be lost as a consequence of negative selective pressure. We tested this hypothesis by infecting innate immunity-deficient C3H/HeJ female mice intravaginally with a human serovar D urogenital isolate that had undergone multiple in vitro passages. We observed early and late infection clearance phenotypes. Strains of each phenotype were isolated and then used to reinfect naive mice. Following infection, the late-clearance strain was significantly more virulent. It caused unvarying infections of much longer durations with greater infectious burdens that naturally ascended to the upper genital tract, causing salpingitis. Despite contrasting in vivo virulence characteristics, the strains exhibited no differences in the results of in vitro infectivity assays or sensitivities to gamma interferon. Genome sequencing of the strains revealed mutations that localized to a single gene (CT135), implicating it as a critical virulence factor. Mutations in CT135 were not unique to serovar D but were also found in multiple oculogenital reference strains. Our findings provide new information about the pathogenomics of chlamydial infection and insights for improving murine models of infection using human strains. JF - Infection and Immunity AU - Sturdevant, Gail L AU - Kari, Laszlo AU - Gardner, Donald J AU - Olivares-Zavaleta, Norma AU - Randall, Linnell B AU - Whitmire, William M AU - Carlson, John H AU - Goheen, Morgan M AU - Selleck, Elizabeth M AU - Martens, Craig AD - Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, hcaldwell@niaid.nih.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 3660 EP - 3668 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 78 IS - 9 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Genomes KW - Salpingitis KW - g-Interferon KW - virulence factors KW - Animal models KW - Chlamydia trachomatis KW - Pathogens KW - Infection KW - Infectivity KW - Pathogenicity KW - Frameshift mutation KW - Genital tract KW - Defense mechanisms KW - Mutation KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754894047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Frameshift+Mutations+in+a+Single+Novel+Virulence+Factor+Alter+the+In+Vivo+Pathogenicity+of+Chlamydia+trachomatis+for+the+Female+Murine+Genital+Tract+%2C+%2C%7C%7C&rft.au=Sturdevant%2C+Gail+L%3BKari%2C+Laszlo%3BGardner%2C+Donald+J%3BOlivares-Zavaleta%2C+Norma%3BRandall%2C+Linnell+B%3BWhitmire%2C+William+M%3BCarlson%2C+John+H%3BGoheen%2C+Morgan+M%3BSelleck%2C+Elizabeth+M%3BMartens%2C+Craig&rft.aulast=Sturdevant&rft.aufirst=Gail&rft.date=2010-09-01&rft.volume=78&rft.issue=9&rft.spage=3660&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00386-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Genomes; Salpingitis; g-Interferon; virulence factors; Animal models; Pathogens; Infection; Infectivity; Frameshift mutation; Pathogenicity; Genital tract; Defense mechanisms; Mutation; Chlamydia trachomatis DO - http://dx.doi.org/10.1128/IAI.00386-10 ER - TY - JOUR T1 - Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H AN - 754893846; 13527115 AB - Vinylogous ureas 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide and N-[3-(aminocarbonyl)-4,5-dimethyl-2-thienyl]-2-furancarboxamide (compounds 1 and 2, respectively) were recently identified to be modestly potent inhibitors of the RNase H activity of HIV-1 and HIV-2 reverse transcriptase (RT). Both compounds shared a 3-CONH2-substituted thiophene ring but were otherwise structurally unrelated, which prevented a precise definition of the pharmacophore. We have therefore examined a larger series of vinylogous ureas carrying amide, amine, and cycloalkane modifications of the thiophene ring of compound 1. While cycloheptane- and cyclohexane-substituted derivatives retained potency, cyclopentane and cyclooctane substitutions eliminated activity. In the presence of a cycloheptane ring, modifying the 2-NH2 or 3-CONH2 functions decreased the potency. With respect to compound 2, vinylogous ureas whose dimethylthiophene ring contained modifications of the 2-NH2 and 3-CONH2 functions were investigated. 2-NH2-modified analogs displayed potency equivalent to or enhanced over that of compound 2, the most active of which, compound 16, reflected intramolecular cyclization of the 2-NH2 and 3-CONH2 groups. Molecular modeling was used to define an inhibitor binding site in the p51 thumb subdomain, suggesting that an interaction with the catalytically conserved His539 of the p66 RNase H domain could underlie inhibition of RNase H activity. Collectively, our data indicate that multiple functional groups of vinylogous ureas contribute to their potencies as RNase H inhibitors. Finally, single-molecule spectroscopy indicates that vinylogous ureas have the property of altering the reverse transcriptase orientation on a model RNA-DNA hybrid mimicking initiation plus-strand DNA synthesis. JF - Antimicrobial Agents & Chemotherapy AU - Chung, Suhman AU - Wendeler, Michaela AU - Rausch, Jason W AU - Beilhartz, Greg AU - Gotte, Matthias AU - O'Keefe, Barry R AU - Bermingham, Alun AU - Beutler, John A AU - Liu, Shixin AU - Zhuang, Xiaowei AD - Department of Chemistry and Chemical Biology, legrices@mail.nih.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 3913 EP - 3921 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 54 IS - 9 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Cyclopentane KW - DNA biosynthesis KW - Data processing KW - Hybrids KW - Immunodeficiency KW - Mimicry KW - Molecular modelling KW - RNA-directed DNA polymerase KW - Ribonuclease H KW - Spectroscopy KW - Urea KW - amides KW - amines KW - pharmacophores KW - Human immunodeficiency virus 1 KW - Human immunodeficiency virus 2 KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - N 14820:DNA Metabolism & Structure KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754893846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Structure-Activity+Analysis+of+Vinylogous+Urea+Inhibitors+of+Human+Immunodeficiency+Virus-Encoded+Ribonuclease+H&rft.au=Chung%2C+Suhman%3BWendeler%2C+Michaela%3BRausch%2C+Jason+W%3BBeilhartz%2C+Greg%3BGotte%2C+Matthias%3BO%27Keefe%2C+Barry+R%3BBermingham%2C+Alun%3BBeutler%2C+John+A%3BLiu%2C+Shixin%3BZhuang%2C+Xiaowei&rft.aulast=Chung&rft.aufirst=Suhman&rft.date=2010-09-01&rft.volume=54&rft.issue=9&rft.spage=3913&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00434-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Number of references - 35 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Mimicry; DNA biosynthesis; Data processing; Immunodeficiency; Urea; Spectroscopy; amines; Hybrids; Ribonuclease H; RNA-directed DNA polymerase; amides; pharmacophores; Cyclopentane; Human immunodeficiency virus 1; Human immunodeficiency virus 2 DO - http://dx.doi.org/10.1128/AAC.00434-10 ER - TY - JOUR T1 - The PB2 Subunit of the Influenza Virus RNA Polymerase Affects Virulence by Interacting with the Mitochondrial Antiviral Signaling Protein and Inhibiting Expression of Beta Interferon AN - 754888595; 13454867 AB - The PB2 subunit of the influenza virus RNA polymerase is a major virulence determinant of influenza viruses. However, the molecular mechanisms involved remain unknown. It was previously shown that the PB2 protein, in addition to its nuclear localization, also accumulates in the mitochondria. Here, we demonstrate that the PB2 protein interacts with the mitochondrial antiviral signaling protein, MAVS (also known as IPS-1, VISA, or Cardif), and inhibits MAVS-mediated beta interferon (IFN-?) expression. In addition, we show that PB2 proteins of influenza viruses differ in their abilities to associate with the mitochondria. In particular, the PB2 proteins of seasonal human influenza viruses localize to the mitochondria while PB2 proteins of avian influenza viruses are nonmitochondrial. This difference in localization is caused by a single amino acid polymorphism in the PB2 mitochondrial targeting signal. In order to address the functional significance of the mitochondrial localization of the PB2 protein in vivo, we have generated two recombinant human influenza viruses encoding either mitochondrial or nonmitochondrial PB2 proteins. We found that the difference in the mitochondrial localization of the PB2 proteins does not affect the growth of these viruses in cell culture. However, the virus encoding the nonmitochondrial PB2 protein induces higher levels of IFN-? and, in an animal model, is attenuated compared to the isogenic virus encoding a mitochondrial PB2. Overall this study implicates the PB2 protein in the regulation of host antiviral innate immune pathways and suggests an important role for the mitochondrial association of the PB2 protein in determining virulence. JF - Journal of Virology AU - Graef, Katy M AU - Vreede, Frank T AU - Lau, Yuk-Fai AU - McCall, Amber W AU - Carr, Simon M AU - Subbarao, Kanta AU - Fodor, Ervin AD - Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom, KSUBBARAO@niaid.nih.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 8433 EP - 8445 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 84 IS - 17 SN - 0022-538X, 0022-538X KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Molecular modelling KW - Amino acids KW - Animal models KW - Mitochondria KW - RNA viruses KW - Cell culture KW - Virulence KW - b-Interferon KW - Fowl plague KW - Interferon KW - DNA-directed RNA polymerase KW - Influenza virus KW - Signal transduction KW - A 01340:Antibiotics & Antimicrobials KW - V 22320:Replication KW - N 14830:RNA KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754888595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=The+PB2+Subunit+of+the+Influenza+Virus+RNA+Polymerase+Affects+Virulence+by+Interacting+with+the+Mitochondrial+Antiviral+Signaling+Protein+and+Inhibiting+Expression+of+Beta+Interferon&rft.au=Graef%2C+Katy+M%3BVreede%2C+Frank+T%3BLau%2C+Yuk-Fai%3BMcCall%2C+Amber+W%3BCarr%2C+Simon+M%3BSubbarao%2C+Kanta%3BFodor%2C+Ervin&rft.aulast=Graef&rft.aufirst=Katy&rft.date=2010-09-01&rft.volume=84&rft.issue=17&rft.spage=8433&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.00879-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - b-Interferon; Virulence; Interferon; Fowl plague; Molecular modelling; DNA-directed RNA polymerase; Amino acids; Animal models; Mitochondria; Cell culture; RNA viruses; Signal transduction; Influenza virus DO - http://dx.doi.org/10.1128/JVI.00879-10 ER - TY - JOUR T1 - Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2-3 mechanism in rats AN - 754536625; 13246729 AB - The metabotropic glutamate receptor 7 (mGluR7) has been reported to be involved in cocaine and alcohol self-administration. However, the role of mGluR7 in relapse to drug seeking is unknown. Using a rat relapse model, we found that systemic administration of AMN082, a selective mGluR7 allosteric agonist, dose-dependently inhibits cocaine-induced reinstatement of drug-seeking behavior. Intracranial microinjections of AMN082 into the nucleus accumbens (NAc) or ventral pallidum, but not the dorsal striatum, also inhibited cocaine-primed reinstatement, an effect that was blocked by local co-administration of MMPIP, a selective mGluR7 antagonist. In vivo microdialysis demonstrated that cocaine priming significantly increased extracellular dopamine in the NAc, ventral pallidum and dorsal striatum, while increasing extracellular glutamate in the NAc only. AMN082 alone failed to alter extracellular dopamine, but produced a slow-onset long-lasting increase in extracellular glutamate in the NAc only. Pre-treatment with AMN082 dose-dependently blocked both cocaine-enhanced NAc glutamate and cocaine-induced reinstatement, an effect that was blocked by MMPIP or LY341497 (a selective mGluR2-3 antagonist). These data suggest that mGluR7 activation inhibits cocaine-induced reinstatement of drug-seeking behavior by a glutamate-mGluR2-3 mechanism in the NAc. The present findings support the potential use of mGluR7 agonists for the treatment of cocaine addiction. JF - Journal of Neurochemistry AU - Li, Xia AU - Li, Jie AU - Gardner, Eliot L AU - Xi, Zheng-Xiong AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, Maryland, USA, zxi@intra.nida.nih.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1368 EP - 1380 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 114 IS - 5 SN - 0022-3042, 0022-3042 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Addiction KW - Allosteric properties KW - Cocaine KW - Data processing KW - Dopamine KW - Drug abuse KW - Drug addiction KW - Drug self-administration KW - Ethanol KW - Globus pallidus KW - Glutamic acid receptors KW - Glutamic acid receptors (metabotropic) KW - Microdialysis KW - Microinjection KW - Neostriatum KW - Nucleus accumbens KW - Reinstatement KW - X 24380:Social Poisons & Drug Abuse KW - N3 11008:Neurochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754536625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=Activation+of+mGluR7s+inhibits+cocaine-induced+reinstatement+of+drug-seeking+behavior+by+a+nucleus+accumbens+glutamate-mGluR2-3+mechanism+in+rats&rft.au=Li%2C+Xia%3BLi%2C+Jie%3BGardner%2C+Eliot+L%3BXi%2C+Zheng-Xiong&rft.aulast=Li&rft.aufirst=Xia&rft.date=2010-09-01&rft.volume=114&rft.issue=5&rft.spage=1368&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/10.1111%2Fj.1471-4159.2010.06851.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Nucleus accumbens; Glutamic acid receptors (metabotropic); Data processing; Drug abuse; Microinjection; Reinstatement; Glutamic acid receptors; Microdialysis; Dopamine; Allosteric properties; Globus pallidus; Neostriatum; Addiction; Drug addiction; Cocaine; Drug self-administration; Ethanol DO - http://dx.doi.org/10.1111/j.1471-4159.2010.06851.x ER - TY - JOUR T1 - Base pairing small RNAs and their roles in global regulatory networks AN - 754535294; 13246273 AB - Bacteria use a range of RNA regulators collectively termed small RNAs (sRNAs) to help respond to changes in the environment. Many sRNAs regulate their target mRNAs through limited base-pairing interactions. Ongoing characterization of base-pairing sRNAs in bacteria has started to reveal how these sRNAs participate in global regulatory networks. These networks can be broken down into smaller regulatory circuits that have characteristic behaviors and functions. In this review, we describe the specific regulatory circuits that incorporate base-pairing sRNAs and the importance of each circuit in global regulation. Because most of these circuits were originally identified as network motifs in transcriptional networks, we also discuss why sRNAs may be used over protein transcription factors to help transduce environmental signals. JF - FEMS Microbiology Reviews AU - Beisel, Chase L AU - Storz, Gisela AD - 1Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 866 EP - 882 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 34 IS - 5 SN - 0168-6445, 0168-6445 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Circuits KW - A 01450:Environmental Pollution & Waste Treatment KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754535294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEMS+Microbiology+Reviews&rft.atitle=Base+pairing+small+RNAs+and+their+roles+in+global+regulatory+networks&rft.au=Beisel%2C+Chase+L%3BStorz%2C+Gisela&rft.aulast=Beisel&rft.aufirst=Chase&rft.date=2010-09-01&rft.volume=34&rft.issue=5&rft.spage=866&rft.isbn=&rft.btitle=&rft.title=FEMS+Microbiology+Reviews&rft.issn=01686445&rft_id=info:doi/10.1111%2Fj.1574-6976.2010.00241.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Circuits DO - http://dx.doi.org/10.1111/j.1574-6976.2010.00241.x ER - TY - JOUR T1 - Fine Mapping of Calcineurin (PPP3CA) Gene Reveals Novel Alternative Splicing Patterns, Association of 5'UTR Trinucleotide Repeat With Addiction Vulnerability, and Differential Isoform Expression in Alzheimer's Disease AN - 754135493; 201020308 AB - Fine mapping of calcineurin (PPP3CA) gene identified single nucleotide polymorphisms (SNPs) and simple sequence repeat polymorphisms that are associated with addiction vulnerability. A trinucleotide repeat marker, located in the 5'untranslated region (5'UTR) of the PPP3CA mRNA, exhibited significantly different genotype and allele frequencies between abusers and controls in the NIDA African-American sample. The polymorphism showed allelic-specific expression in mRNA extracted from postmortem brain specimens. Novel alternatively spliced isoforms of PPP3CA were identified and their expressions were found altered in brain regions of postmortem Alzheimer's disease patients. These data underscore the importance of calcineurin gene in the molecular mechanism of addiction and Alzheimer's diseases. Adapted from the source document. JF - Substance Use & Misuse AU - Chiocco, Matthew J AU - Zhu, Xuguang AU - Walther, Donna AU - Pletnikova, Olga AU - Troncoso, Juan C AU - Uhl, George R AU - Liu, Qing-Rong AD - Molecular Neurobiology Branch, NIH-IRP, NIDA, DHHS, Baltimore, Maryland, USA Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 1809 EP - 1826 PB - Taylor & Francis, Philadelphia PA VL - 45 IS - 11 SN - 1082-6084, 1082-6084 KW - Genes KW - Fines KW - Alzheimer's disease KW - Brain KW - Vulnerability KW - Addiction KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754135493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+Use+%26+Misuse&rft.atitle=Fine+Mapping+of+Calcineurin+%28PPP3CA%29+Gene+Reveals+Novel+Alternative+Splicing+Patterns%2C+Association+of+5%27UTR+Trinucleotide+Repeat+With+Addiction+Vulnerability%2C+and+Differential+Isoform+Expression+in+Alzheimer%27s+Disease&rft.au=Chiocco%2C+Matthew+J%3BZhu%2C+Xuguang%3BWalther%2C+Donna%3BPletnikova%2C+Olga%3BTroncoso%2C+Juan+C%3BUhl%2C+George+R%3BLiu%2C+Qing-Rong&rft.aulast=Chiocco&rft.aufirst=Matthew&rft.date=2010-09-01&rft.volume=45&rft.issue=11&rft.spage=1809&rft.isbn=&rft.btitle=&rft.title=Substance+Use+%26+Misuse&rft.issn=10826084&rft_id=info:doi/10.3109%2F10826084.2010.482449 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-08-09 N1 - Last updated - 2016-09-27 N1 - CODEN - SUMIFL N1 - SubjectsTermNotLitGenreText - Alzheimer's disease; Addiction; Genes; Brain; Vulnerability; Fines DO - http://dx.doi.org/10.3109/10826084.2010.482449 ER - TY - JOUR T1 - Loop 1 modulates the fidelity of DNA polymerase lambda. AN - 754006744; 20435673 AB - Differences in the substrate specificity of mammalian family X DNA polymerases are proposed to partly depend on a loop (loop 1) upstream of the polymerase active site. To examine if this is the case in DNA polymerase λ (pol λ), here we characterize a variant of the human polymerase in which nine residues of loop 1 are replaced with four residues from the equivalent position in pol β. Crystal structures of the mutant enzyme bound to gapped DNA with and without a correct dNTP reveal that the change in loop 1 does not affect the overall structure of the protein. Consistent with these structural data, the mutant enzyme has relatively normal catalytic efficiency for correct incorporation, and it efficiently participates in non-homologous end joining of double-strand DNA breaks. However, DNA junctions recovered from end-joining reactions are more diverse than normal, and the mutant enzyme is substantially less accurate than wild-type pol λ in three different biochemical assays. Comparisons of the binary and ternary complex crystal structures of mutant and wild-type pol λ suggest that loop 1 modulates pol λ's fidelity by controlling dNTP-induced movements of the template strand and the primer-terminal 3'-OH as the enzyme transitions from an inactive to an active conformation. JF - Nucleic acids research AU - Bebenek, Katarzyna AU - Garcia-Diaz, Miguel AU - Zhou, Rui-Zhe AU - Povirk, Lawrence F AU - Kunkel, Thomas A AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA. Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 5419 EP - 5431 VL - 38 IS - 16 KW - Deoxyribonucleotides KW - 0 KW - DNA KW - 9007-49-2 KW - DNA Polymerase beta KW - EC 2.7.7.- KW - DNA polymerase beta2 KW - Index Medicus KW - Conserved Sequence KW - Models, Molecular KW - Kinetics KW - Humans KW - Molecular Sequence Data KW - Deoxyribonucleotides -- metabolism KW - Crystallography, X-Ray KW - Amino Acid Sequence KW - DNA -- biosynthesis KW - Protein Conformation KW - Biocatalysis KW - DNA Polymerase beta -- chemistry KW - DNA Polymerase beta -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754006744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=Loop+1+modulates+the+fidelity+of+DNA+polymerase+lambda.&rft.au=Bebenek%2C+Katarzyna%3BGarcia-Diaz%2C+Miguel%3BZhou%2C+Rui-Zhe%3BPovirk%2C+Lawrence+F%3BKunkel%2C+Thomas+A&rft.aulast=Bebenek&rft.aufirst=Katarzyna&rft.date=2010-09-01&rft.volume=38&rft.issue=16&rft.spage=5419&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/10.1093%2Fnar%2Fgkq261 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-13 N1 - Date created - 2010-09-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell. 2004 Feb 27;13(4):561-72 [14992725] J Biol Chem. 2004 Jan 2;279(1):805-11 [14561766] J Biol Chem. 2004 Apr 23;279(17):16895-8 [14988392] Immunol Rev. 2004 Aug;200:156-64 [15242403] Acta Crystallogr A. 1991 Mar 1;47 ( Pt 2):110-9 [2025413] Science. 1993 Aug 27;261(5125):1171-5 [8356451] Science. 1993 Aug 27;261(5125):1175-8 [8356452] Methods Enzymol. 1995;262:217-32 [8594349] Int J Radiat Biol. 1996 Dec;70(6):623-36 [8980659] Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21 [9757107] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] Mol Cell. 2004 Dec 3;16(5):701-13 [15574326] Nat Struct Mol Biol. 2005 Jan;12(1):97-8 [15608652] J Biol Chem. 2005 May 6;280(18):18469-75 [15749700] Mol Cell. 2005 Aug 5;19(3):357-66 [16061182] Cell. 2006 Jan 27;124(2):331-42 [16439207] Trends Biochem Sci. 2006 Apr;31(4):206-14 [16545956] Immunity. 2006 Jul;25(1):31-41 [16860755] Nucleic Acids Res. 2006;34(16):4572-82 [16963491] Nucleic Acids Res. 2007;35(12):3869-78 [17526517] Nucleic Acids Res. 2007 Jul;35(Web Server issue):W375-83 [17452350] DNA Repair (Amst). 2007 Dec 1;6(12):1709-25 [17631059] J Biol Chem. 2008 Jan 4;283(1):1-5 [17999957] Nucleic Acids Res. 2008 May;36(9):2895-905 [18385158] Nucleic Acids Res. 2008 May;36(9):3085-94 [18397950] DNA Repair (Amst). 2008 Nov 1;7(11):1824-34 [18692600] Mol Cell Biol. 2009 Mar;29(5):1266-75 [19103746] Nucleic Acids Res. 2009 Aug;37(14):4642-56 [19502493] Nat Struct Mol Biol. 2009 Sep;16(9):967-72 [19701199] Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16203-8 [19805281] Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18201-6 [19820168] Nature. 2000 Jun 15;405(6788):807-10 [10866204] J Biol Chem. 2000 Sep 8;275(36):28033-8 [10851238] J Biol Chem. 2001 Sep 14;276(37):34659-63 [11457865] EMBO J. 2002 Feb 1;21(3):427-39 [11823435] Mol Cell Biol. 2002 Jul;22(14):5194-202 [12077346] Acta Crystallogr D Biol Crystallogr. 2002 Nov;58(Pt 11):1948-54 [12393927] Cold Spring Harb Symp Quant Biol. 2000;65:143-55 [12760029] Biochemistry. 2003 Jun 24;42(24):7467-76 [12809503] Immunity. 2003 Aug;19(2):203-11 [12932354] J Biol Chem. 2003 Sep 5;278(36):34685-90 [12829698] J Biol Chem. 2003 Dec 12;278(50):50537-45 [14523013] Cell. 2004 Mar 19;116(6):803-16 [15035983] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/nar/gkq261 ER - TY - JOUR T1 - Identification and validation of effective connectivity networks in functional magnetic resonance imaging using switching linear dynamic systems AN - 753686370; 13259797 AB - Dynamic connectivity networks identify directed interregional interactions between modeled brain regions in neuroimaging. However, problems arise when the regions involved in a task and their interconnections are not fully known a priori. Objective measures of model adequacy are necessary to validate such models. We present a connectivity formalism, the Switching Linear Dynamic System (SLDS), that is capable of identifying both Granger-Geweke and instantaneous connectivity that vary according to experimental conditions. SLDS explicitly models the task condition as a Markov random variable. The series of task conditions can be estimated from new data given an identified model providing a means to validate connectivity patterns. We use SLDS to model functional magnetic resonance imaging data from five regions during a finger alternation task. Using interregional connectivity alone, the identified model predicted the task condition vector from a different subject with a different task ordering with high accuracy. In addition, important regions excluded from a model can be identified by augmenting the model state space. A motor task model excluding primary motor cortices was augmented with a new neural state constrained by its connectivity with the included regions. The augmented variable time series, convolved with a hemodynamic kernel, was compared to all brain voxels. The right primary motor cortex was identified as the best region to add to the model. Our results suggest that the SLDS model framework is an effective means to address several problems with modeling connectivity including measuring overall model adequacy and identifying important regions missing from models. JF - NeuroImage AU - Smith, Jason F AU - Pillai, Ajay AU - Chen, Kewei AU - Horwitz, Barry AD - Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda MD, USA, smithjas@nidcd.nih.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1027 EP - 1040 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 52 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Dynamic systems KW - fMRI KW - Effective connectivity KW - Motor systems KW - Computational modeling KW - Brain mapping KW - Neuroimaging KW - Cortex (motor) KW - Data processing KW - Neural networks KW - Functional magnetic resonance imaging KW - Hemodynamics KW - Kernels KW - Finger KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753686370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Identification+and+validation+of+effective+connectivity+networks+in+functional+magnetic+resonance+imaging+using+switching+linear+dynamic+systems&rft.au=Smith%2C+Jason+F%3BPillai%2C+Ajay%3BChen%2C+Kewei%3BHorwitz%2C+Barry&rft.aulast=Smith&rft.aufirst=Jason&rft.date=2010-09-01&rft.volume=52&rft.issue=3&rft.spage=1027&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2009.11.081 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Brain mapping; Cortex (motor); Neuroimaging; Data processing; Neural networks; Functional magnetic resonance imaging; Kernels; Hemodynamics; Finger DO - http://dx.doi.org/10.1016/j.neuroimage.2009.11.081 ER - TY - JOUR T1 - Glucarpidase, leucovorin, and thymidine for high-dose methotrexate-induced renal dysfunction: clinical and pharmacologic factors affecting outcome. AN - 749026665; 20679598 AB - To assess the role of the recombinant bacterial enzyme, glucarpidase (carboxypeptidase-G(2)), leucovorin, and thymidine in the management and outcome of patients with high-dose methotrexate (HDMTX) -induced nephrotoxicity. Patients with HDMTX-induced nephrotoxicity received one to three doses of intravenous (IV) glucarpidase and leucovorin rescue. The initial cohort (n = 35) also received thymidine by continuous IV infusion. Subsequently, thymidine was restricted to patients with prolonged exposure (> 96 hours) to methotrexate (MTX) or with substantial MTX toxicity at study entry. Plasma MTX, leucovorin, and 5-methyltetrahydrofolate (5-mTHF) concentrations were measured pre- and postglucarpidase. Toxicities were monitored, and logistic regression analysis was used to assess the relationship of baseline characteristics to the development of severe toxicity and death. Glucarpidase was administered at a median of 96 hours (receiving thymidine, n = 44) and 66 hours (not receiving thymidine, n = 56) after the start of the MTX infusion. Plasma MTX concentrations decreased within 15 minutes of glucarpidase by 98.7%. Plasma 5-mTHF concentrations also decreased more than 98% after administration of glucarpidase. Of 12 deaths, six were directly attributed to irreversible MTX toxicity. Presence of grade 4 toxicity before administration of glucarpidase, inadequate initial increase in leucovorin dosing, and administration of glucarpidase more than 96 hours after the start of the MTX infusion were associated with development of grade 4 and 5 toxicity. Early intervention with the combination of leucovorin and glucarpidase is highly effective in patients who develop HDMTX-induced renal dysfunction. Severe toxicity and mortality occurred in patients in whom glucarpidase rescue was delayed and occurred despite thymidine administration. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Widemann, Brigitte C AU - Balis, Frank M AU - Kim, AeRang AU - Boron, Matthew AU - Jayaprakash, Nalini AU - Shalabi, Aiman AU - O'Brien, Michelle AU - Eby, Michelle AU - Cole, Diane E AU - Murphy, Robert F AU - Fox, Elizabeth AU - Ivy, Percy AU - Adamson, Peter C AD - Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892-1101, USA. widemanb@mail.nih.gov Y1 - 2010/09/01/ PY - 2010 DA - 2010 Sep 01 SP - 3979 EP - 3986 VL - 28 IS - 25 KW - gamma-Glutamyl Hydrolase KW - EC 3.4.19.9 KW - Leucovorin KW - Q573I9DVLP KW - Thymidine KW - VC2W18DGKR KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Drug Therapy, Combination -- adverse effects KW - Drug Administration Schedule KW - Humans KW - Aged KW - Child KW - Child, Preschool KW - Infant KW - Aged, 80 and over KW - Adult KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Thymidine -- administration & dosage KW - Leucovorin -- blood KW - gamma-Glutamyl Hydrolase -- administration & dosage KW - Methotrexate -- blood KW - Methotrexate -- adverse effects KW - Kidney Diseases -- blood KW - gamma-Glutamyl Hydrolase -- blood KW - Leucovorin -- administration & dosage KW - Methotrexate -- administration & dosage KW - Thymidine -- blood KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/749026665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Glucarpidase%2C+leucovorin%2C+and+thymidine+for+high-dose+methotrexate-induced+renal+dysfunction%3A+clinical+and+pharmacologic+factors+affecting+outcome.&rft.au=Widemann%2C+Brigitte+C%3BBalis%2C+Frank+M%3BKim%2C+AeRang%3BBoron%2C+Matthew%3BJayaprakash%2C+Nalini%3BShalabi%2C+Aiman%3BO%27Brien%2C+Michelle%3BEby%2C+Michelle%3BCole%2C+Diane+E%3BMurphy%2C+Robert+F%3BFox%2C+Elizabeth%3BIvy%2C+Percy%3BAdamson%2C+Peter+C&rft.aulast=Widemann&rft.aufirst=Brigitte&rft.date=2010-09-01&rft.volume=28&rft.issue=25&rft.spage=3979&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2009.25.4540 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-06 N1 - Date created - 2010-08-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pediatr Hematol Oncol. 1995 Nov-Dec;12(6):521-4 [8588996] Pediatr Hematol Oncol. 1995 Sep-Oct;12(5):471-7 [8519632] J Clin Oncol. 1997 May;15(5):2125-34 [9164227] Bull Cancer. 1998 Dec;85(12):1066 [9917559] Clin Chem. 1999 Feb;45(2):223-8 [9931044] J Pediatr Hematol Oncol. 1999 Mar-Apr;21(2):165-9 [10206466] Br J Cancer. 2005 Feb 14;92(3):480-7 [15668713] Cancer Chemother Pharmacol. 2005 Apr;55(4):347-53 [15723260] Oncologist. 2006 Jun;11(6):694-703 [16794248] Eur J Clin Pharmacol. 2007 Jan;63(1):39-42 [17115148] Am J Health Syst Pharm. 2007 Jun 1;64(11):1163-9 [17519458] J Pediatr Hematol Oncol. 2007 Jul;29(7):496-9 [17609630] Oncologist. 2007 Nov;12(11):1299-308 [18055849] J Clin Pharmacol. 2008 Mar;48(3):279-84 [18192538] J Pediatr Hematol Oncol. 2008 Dec;30(12):950-2 [19131789] Cancer. 1995 Aug 1;76(3):521-6 [8625136] Leuk Lymphoma. 1999 Nov;35(5-6):631-5 [10609804] Leuk Lymphoma. 2000 Apr;37(3-4):441-3 [10752997] J Pharmacol Exp Ther. 2000 Sep;294(3):894-901 [10945838] Med Klin (Munich). 2000 Aug 15;95(8):457-60 [10985069] Leuk Lymphoma. 2002 Nov;43(11):2139-43 [12533039] Ann Pharmacother. 2004 Mar;38(3):422-7 [14970366] J Natl Cancer Inst. 2004 Oct 20;96(20):1557-9 [15494606] Cancer Treat Rev. 1977 Jun;4(2):87-101 [329989] Am J Med. 1980 Mar;68(3):370-6 [6965819] Cancer Res. 1980 Jun;40(6):1824-9 [7371013] J Clin Oncol. 1992 Aug;10(8):1359-64 [1634927] Comment In: J Clin Oncol. 2011 Mar 1;29(7):e180; author reply e181 [21220601] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1200/JCO.2009.25.4540 ER - TY - JOUR T1 - Polycyclic aromatic hydrocarbon exposure in oesophageal tissue and risk of oesophageal squamous cell carcinoma in north-eastern Iran. AN - 749026602; 20584779 AB - To evaluate the association between polycyclic aromatic hydrocarbon (PAH) exposure in oesophageal epithelial tissue and oesophageal squamous cell carcinoma (ESCC) case status in an ESCC case-control study in a high-risk population in north-eastern Iran. Tissue microarrays (TMAs) of non-tumoral oesophageal biopsies from patients with biopsy-proven ESCC and gastrointestinal clinic patients with no endoscopic or biopsy evidence of ESCC (control subjects) in a rural region in north-eastern Iran were immunohistochemically stained. Immunohistochemistry was performed using monoclonal antibodies 8E11 and 5D11 raised against benzo[a]pyrene (B[a]P) diol epoxide (BPDE)-I-modified guanosine and BPDE-I-modified DNA, respectively. Staining intensity was quantified by image analysis and the average staining in three replicates was calculated. The main outcome measure was adjusted ORs with 95% CIs for the association between antibody staining intensity and ESCC case status. Cultured ESCC cells exposed to B[a]P in vitro showed dose-dependent staining with 8E11 but not with 5D11. With 8E11, sufficient epithelial tissue was available in the TMA cores to analyse 91 cases and 103 controls. Compared with the lowest quintile of 8E11 staining in the controls, adjusted ORs for the 2nd to 5th quintiles were 2.42, 5.77, 11.3 and 26.6 (95% CI 5.21 to 135), respectively (p for trend <0.001). With 5D11, 89 cases and 101 controls were analysed. No association between staining and case status was observed (ORs for the 2nd to 5th quintiles were 1.26, 0.88, 1.06 and 1.63 (95% CI 0.63 to 4.21), p for trend=0.40). Dramatically higher levels of 8E11 staining were observed in non-tumoral oesophageal epithelium from patients with ESCC than from control subjects. This finding strengthens the evidence for a causal role for PAHs in oesophageal carcinogenesis in north-eastern Iran. JF - Gut AU - Abedi-Ardekani, Behnoush AU - Kamangar, Farin AU - Hewitt, Stephen M AU - Hainaut, Pierre AU - Sotoudeh, Masoud AU - Abnet, Christian C AU - Taylor, Philip R AU - Boffetta, Paolo AU - Malekzadeh, Reza AU - Dawsey, Sanford M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rm 3018, Bethesda, MD 20892-7232, USA. Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 1178 EP - 1183 VL - 59 IS - 9 KW - Polycyclic Aromatic Hydrocarbons KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Tumor Cells, Cultured KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Biopsy KW - Image Processing, Computer-Assisted KW - Male KW - Female KW - Polycyclic Aromatic Hydrocarbons -- toxicity KW - Esophageal Neoplasms -- chemically induced KW - Carcinoma, Squamous Cell -- pathology KW - Polycyclic Aromatic Hydrocarbons -- analysis KW - Carcinoma, Squamous Cell -- chemically induced KW - Esophageal Neoplasms -- chemistry KW - Carcinoma, Squamous Cell -- chemistry KW - Esophageal Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/749026602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gut&rft.atitle=Polycyclic+aromatic+hydrocarbon+exposure+in+oesophageal+tissue+and+risk+of+oesophageal+squamous+cell+carcinoma+in+north-eastern+Iran.&rft.au=Abedi-Ardekani%2C+Behnoush%3BKamangar%2C+Farin%3BHewitt%2C+Stephen+M%3BHainaut%2C+Pierre%3BSotoudeh%2C+Masoud%3BAbnet%2C+Christian+C%3BTaylor%2C+Philip+R%3BBoffetta%2C+Paolo%3BMalekzadeh%2C+Reza%3BDawsey%2C+Sanford+M&rft.aulast=Abedi-Ardekani&rft.aufirst=Behnoush&rft.date=2010-09-01&rft.volume=59&rft.issue=9&rft.spage=1178&rft.isbn=&rft.btitle=&rft.title=Gut&rft.issn=1468-3288&rft_id=info:doi/10.1136%2Fgut.2010.210609 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-07 N1 - Date created - 2010-08-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Carcinogenesis. 2000 Mar;21(3):353-9 [10688855] Food Chem Toxicol. 2001 May;39(5):423-36 [11313108] J Natl Cancer Inst. 2003 Sep 17;95(18):1404-13 [13130116] Nat Rev Cancer. 2003 Oct;3(10):733-44 [14570033] Mutat Res. 2004 Mar 22;547(1-2):55-62 [15013699] Cancer Epidemiol Biomarkers Prev. 2004 Jun;13(6):1068-70 [15184266] Science. 1972 Feb 25;175(4024):846-53 [5008604] Br J Cancer. 1973 Sep;28(3):197-214 [4743904] Carcinogenesis. 1984 Mar;5(3):373-7 [6423306] Environ Health Perspect. 1985 Oct;62:95-9 [4085452] Carcinogenesis. 1986 Mar;7(3):441-4 [3948329] Carcinogenesis. 1994 Mar;15(3):483-7 [8118933] Environ Health Perspect. 1993 Oct;101 Suppl 3:37-42 [8143643] Environ Health Perspect. 1996 Oct;104 Suppl 5:927-32 [8933036] Environ Health Perspect. 1996 Nov;104(11):1166-70 [8959405] Int J Cancer. 2005 Jan 20;113(3):456-63 [15455378] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Anticancer Res. 2005 Jan-Feb;25(1B):425-8 [15816606] Int J Epidemiol. 2005 Apr;34(2):467-74 [15659476] Lancet Oncol. 2005 Dec;6(12):931-2 [16353404] Cancer Detect Prev. 2006;30(1):14-9 [16495018] Environ Pollut. 2006 Aug;142(3):388-96 [16343719] J Clin Oncol. 2006 May 10;24(14):2137-50 [16682732] Am J Epidemiol. 2007 Jun 15;165(12):1424-33 [17420181] Mutat Res. 2007 Nov 1;624(1-2):114-23 [17583755] Nutr Cancer. 2008;60(2):216-21 [18444153] Br J Cancer. 2008 Jun 3;98(11):1857-63 [18475303] Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3062-8 [18990747] Prostate. 2009 Apr 1;69(5):505-19 [19143007] BMJ. 2009;338:b929 [19325180] J Natl Cancer Inst. 2009 Apr 1;101(7):507-18 [19318634] Int J Epidemiol. 2009 Aug;38(4):978-88 [19416955] Int J Epidemiol. 2010 Feb;39(1):52-9 [19332502] Comment In: Arch Iran Med. 2010 Sep;13(5):457-8 [20804319] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/gut.2010.210609 ER - TY - JOUR T1 - Prolonged QTc interval in cancer therapeutic drug development: defining arrhythmic risk in malignancy. AN - 749021552; 20728704 AB - Anticancer therapy drug development is an arduous task, taking 10 to 15 years to complete, requiring approximately 1 billion dollars, and rarely leads to Food and Drug Administration approval. Methods to predict unacceptable drug-induced toxicity, such as a prolonged QTc interval/risk of torsade de pointes, should be highly informative to quickly and accurately determine if further resources should be allocated in the continued development of an agent. Expert consensus has established guidelines to ascertain the ability of a new drug to prolong the QTc interval. Although QTc measurement is the best way to assess arrhythmic risk, it is imprecise for a variety of reasons. In addition, oncology patients have multiple risk factors for QTc prolongation at baseline. Competing interests involved in assessing arrhythmic risk of a new oncology agent include inability to precisely follow published guidelines for QTc assessment, patients' concomitant medical problems interfering with drug assessment and therefore clinical trial enrollment, patient safety concerns, general public safety concerns regarding toxicity assessment, need for discovery of more curative drug therapies, and individual patient perception of therapeutic risk vs benefit. Oncology patients are concerned about access to experimental agents, as well as early abandonment of a potentially beneficial agent because of a low estimated risk of toxicity, even if the event is catastrophic. We review the issues involved in evaluating the QTc interval-prolonging risk in new anticancer agents. Copyright 2010 Elsevier Inc. All rights reserved. JF - Progress in cardiovascular diseases AU - Brell, Joanna M AD - Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, 6130 Executive Blvd. EPN 2017, Bethesda, MD 20892, USA. brelljm@mail.nih.gov PY - 2010 SP - 164 EP - 172 VL - 53 IS - 2 KW - Antineoplastic Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Animals KW - Risk Factors KW - Humans KW - Drug Approval KW - Practice Guidelines as Topic KW - Action Potentials KW - Torsades de Pointes -- chemically induced KW - Time Factors KW - Structure-Activity Relationship KW - Risk Assessment KW - Neoplasms -- drug therapy KW - Arrhythmias, Cardiac -- diagnosis KW - Arrhythmias, Cardiac -- chemically induced KW - Heart Conduction System -- drug effects KW - Neoplasms -- physiopathology KW - Heart Conduction System -- physiopathology KW - Antineoplastic Agents -- chemistry KW - Drug Design KW - Arrhythmias, Cardiac -- physiopathology KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/749021552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+cardiovascular+diseases&rft.atitle=Prolonged+QTc+interval+in+cancer+therapeutic+drug+development%3A+defining+arrhythmic+risk+in+malignancy.&rft.au=Brell%2C+Joanna+M&rft.aulast=Brell&rft.aufirst=Joanna&rft.date=2010-09-01&rft.volume=53&rft.issue=2&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Progress+in+cardiovascular+diseases&rft.issn=1873-1740&rft_id=info:doi/10.1016%2Fj.pcad.2010.05.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-27 N1 - Date created - 2010-08-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cardiovasc Res. 2000 Aug;47(2):219-33 [10947683] Clin Pharmacol Ther. 2009 Jul;86(1):101-4 [19474784] J Cardiovasc Pharmacol. 2001 Nov;38(5):737-44 [11602820] Am Heart J. 2002 Nov;144(5):769-81 [12422144] Cardiovasc Res. 2003 Apr 1;58(1):32-45 [12667944] N Engl J Med. 2003 May 8;348(19):1866-74 [12736279] J Clin Oncol. 2003 Sep 1;21(17):3378-9 [12947082] J Clin Oncol. 2003 Oct 1;21(19):3609-15 [14512391] N Engl J Med. 2004 Mar 4;350(10):1013-22 [14999113] Cardiovasc Drugs Ther. 1991 Apr;5(2):515-30 [1854661] J Am Coll Cardiol. 1996 Jan;27(1):76-83 [8522713] J Cardiovasc Electrophysiol. 1998 Oct;9(10):1109-13 [9817562] J Clin Oncol. 2005 Oct 20;23(30):7685-96 [16234530] Heart Rhythm. 2005 Nov;2(2 Suppl):S30-7 [16253929] AAPS J. 2006;8(1):E89-94 [16584137] Clin Cancer Res. 2006 Jun 15;12(12):3762-73 [16778104] Clin Cancer Res. 2006 Jul 1;12(13):3871-4 [16818679] J Clin Oncol. 2006 Sep 20;24(27):4479-84 [16983117] Nat Rev Cancer. 2007 Feb;7(2):131-9 [17251919] J Clin Oncol. 2007 Aug 1;25(22):3362-71 [17664484] Europace. 2007 Sep;9 Suppl 4:iv16-22 [17766320] J Clin Pharmacol. 2008 Jan;48(1):13-8 [18094216] Expert Opin Drug Saf. 2008 May;7(3):305-18 [18462188] Pharmacol Ther. 2008 Aug;119(2):215-21 [18455801] Am Heart J. 2009 May;157(5):827-36, 836.e1 [19376308] Eur J Clin Pharmacol. 2000 Apr;56(1):1-18 [10853872] Drug Saf. 1999;21 Suppl 1:5-10; discussion 81-7 [10597863] Prog Cardiovasc Dis. 2001 Mar-Apr;43(5 Suppl 1):1-45 [11269621] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.pcad.2010.05.005 ER - TY - JOUR T1 - Structural modifications of nucleosides in ionic liquids. AN - 749005898; 20178825 AB - Nucleoside chemistry represents an important research area for drug discovery, as many nucleoside analogs are prominent drugs and have been widely applied for cancer and viral chemotherapy. However, the synthesis of modified nucleosides presents a major challenge, which is further aggravated by poor solubility of these compounds in common organic solvents. Most of the currently available methods for nucleoside modification employ toxic high boiling solvents; require long reaction time and tedious workup methods. As such, there is constant effort to develop process chemistry in alternative medium to limit the use of organic solvents that are hazardous to the environment and can be deleterious to human health. One such approach is to use ionic liquids, which are 'designer materials' with unique and tunable physico-chemical properties. Studies have shown that methodologies using ionic liquids are highly efficient and convenient for the synthesis of nucleoside analogs, as demonstrated by the preparation of pharmaceutically important anti-viral drugs. This article summarizes recent efforts on nucleoside modification using ionic liquids. Copyright (c) 2010 Elsevier Masson SAS. All rights reserved. JF - Biochimie AU - Kumar, Vineet AU - Parmar, Virinder S AU - Malhotra, Sanjay V AD - Laboratory of Synthetic Chemistry, SAIC -Frederick Inc., National Cancer Institute at Frederick, 1050 Boyles St., Frederick, MD 21702, USA. Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 1260 EP - 1265 VL - 92 IS - 9 KW - Antiviral Agents KW - 0 KW - Ionic Liquids KW - Nucleosides KW - Index Medicus KW - Antiviral Agents -- chemistry KW - Ionic Liquids -- chemistry KW - Nucleosides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/749005898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimie&rft.atitle=Structural+modifications+of+nucleosides+in+ionic+liquids.&rft.au=Kumar%2C+Vineet%3BParmar%2C+Virinder+S%3BMalhotra%2C+Sanjay+V&rft.aulast=Kumar&rft.aufirst=Vineet&rft.date=2010-09-01&rft.volume=92&rft.issue=9&rft.spage=1260&rft.isbn=&rft.btitle=&rft.title=Biochimie&rft.issn=1638-6183&rft_id=info:doi/10.1016%2Fj.biochi.2010.02.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-20 N1 - Date created - 2010-08-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Med Chem. 2007 Jun 14;50(12):2851-7 [17518459] Bioorg Med Chem Lett. 2008 Oct 15;18(20):5640-2 [18796352] Mol Divers. 2009 Feb;13(1):57-61 [19067214] Nucleosides Nucleotides Nucleic Acids. 2009 Sep;28(9):821-34 [20183621] Chem Commun (Camb). 2004 May 7;(9):1033-43 [15116175] J Org Chem. 1966 Jan;31(1):205-11 [5900814] Mol Pharmacol. 1981 Mar;19(2):321-30 [7231392] Drugs. 1982 May;23(5):329-53 [6284470] Chem Pharm Bull (Tokyo). 1988 Mar;36(3):945-53 [3409411] J Med Chem. 1989 Feb;32(2):461-6 [2536441] Antiviral Res. 1990 Sep;14(3):125-48 [2080869] AIDS Res Hum Retroviruses. 1992 Feb;8(2):119-34 [1371690] AIDS Res Hum Retroviruses. 1992 Jun;8(6):963-90 [1503830] Nature. 1994 Nov 24;372(6504):333-5 [7969490] Med Res Rev. 2005 Jan;25(1):1-20 [15389733] Bioorg Med Chem. 2005 Jul 15;13(14):4467-72 [15921912] Antiviral Res. 2005 Aug;67(2):56-75 [16046240] Curr Opin Microbiol. 2005 Oct;8(5):552-60 [16125443] Bioorg Med Chem. 2005 Dec 15;13(24):6663-71 [16140016] Antiviral Res. 2006 Sep;71(2-3):276-81 [16797735] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.biochi.2010.02.019 ER - TY - JOUR T1 - Epigenetic regulation of cancer stem cells in liver cancer: current concepts and clinical implications. AN - 748987656; 20646772 AB - The two dominant models of carcinogenesis postulate stochastic (clonal evolution) or hierarchic organization of tumor (cancer stem cell model). According to the latter, at the germinal center of tumor evolution is a cancer stem cell (CSC) which, similar to normal adult stem cells, possesses the capacity of self-renewal and a differentiation potential. Over the past few years, compelling evidence has emerged in support of the hierarchic cancer model for many solid tumors including hepatocellular cancers. The CSCs are posited to be responsible not only for tumor initiation but also for the generation of distant metastasis and relapse after therapy. These characteristics are particularly relevant for a multi-resistant tumor entity like human hepatocellular carcinoma and may herald a paradigm shift in the management of this deadly disease. Identification and detailed characterization of liver CSCs is therefore imperative for improving prevention approaches, enhancing early detection, and extending the limited treatment options. Despite the current progress in understanding the contribution of CSCs to the generation of heterogeneity of tumors, the molecular complexity and exact regulation of CSCs is poorly understood. This review focuses on the genetic and epigenetic mechanisms that regulate and define the unique CSC properties with an emphasis on key regulatory pathways of liver CSCs and their clinical significance. Copyright 2010. Published by Elsevier B.V. JF - Journal of hepatology AU - Marquardt, J U AU - Factor, V M AU - Thorgeirsson, S S AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, MD, USA. Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 568 EP - 577 VL - 53 IS - 3 KW - AC133 Antigen KW - 0 KW - Antigens, CD KW - Antigens, Neoplasm KW - Antigens, Thy-1 KW - BMI1 protein, human KW - CTNNB1 protein, human KW - Cell Adhesion Molecules KW - EPCAM protein, human KW - Epithelial Cell Adhesion Molecule KW - Glycoproteins KW - Hedgehog Proteins KW - MicroRNAs KW - Nuclear Proteins KW - Peptides KW - Proto-Oncogene Proteins KW - RNA, Neoplasm KW - Receptors, Notch KW - Repressor Proteins KW - SHH protein, human KW - Transforming Growth Factor beta KW - Wnt Proteins KW - beta Catenin KW - Aldehyde Dehydrogenase KW - EC 1.2.1.3 KW - Polycomb Repressive Complex 1 KW - EC 2.3.2.27 KW - Index Medicus KW - Nuclear Proteins -- genetics KW - Humans KW - Models, Biological KW - Receptors, Notch -- metabolism KW - Cell Separation -- methods KW - Wnt Proteins -- metabolism KW - Neoplasm Metastasis -- genetics KW - beta Catenin -- metabolism KW - Antigens, Thy-1 -- metabolism KW - Cell Adhesion Molecules -- metabolism KW - Antigens, Neoplasm -- metabolism KW - Aldehyde Dehydrogenase -- metabolism KW - Proto-Oncogene Proteins -- genetics KW - Signal Transduction KW - Cell Division KW - Genes, myc KW - MicroRNAs -- genetics KW - Peptides -- metabolism KW - RNA, Neoplasm -- genetics KW - Repressor Proteins -- genetics KW - Hedgehog Proteins -- metabolism KW - Glycoproteins -- metabolism KW - Antigens, CD -- metabolism KW - Neoplasm Metastasis -- pathology KW - Transforming Growth Factor beta -- metabolism KW - Liver Neoplasms -- pathology KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Neoplastic Stem Cells -- physiology KW - Neoplastic Stem Cells -- pathology KW - Carcinoma, Hepatocellular -- secondary KW - Carcinoma, Hepatocellular -- genetics KW - Carcinoma, Hepatocellular -- pathology KW - Epigenesis, Genetic KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748987656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hepatology&rft.atitle=Epigenetic+regulation+of+cancer+stem+cells+in+liver+cancer%3A+current+concepts+and+clinical+implications.&rft.au=Marquardt%2C+J+U%3BFactor%2C+V+M%3BThorgeirsson%2C+S+S&rft.aulast=Marquardt&rft.aufirst=J&rft.date=2010-09-01&rft.volume=53&rft.issue=3&rft.spage=568&rft.isbn=&rft.btitle=&rft.title=Journal+of+hepatology&rft.issn=1600-0641&rft_id=info:doi/10.1016%2Fj.jhep.2010.05.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-07 N1 - Date created - 2010-08-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Chim Acta. 2002 Dec;326(1-2):27-45 [12417095] Lancet. 2003 Mar 15;361(9361):923-9 [12648972] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 [12629218] Nat Med. 2003 Apr;9(4):416-23 [12640447] Nature. 2003 May 15;423(6937):302-5 [12714971] Am J Pathol. 2003 Oct;163(4):1371-8 [14507645] Lancet. 2003 Dec 6;362(9399):1907-17 [14667750] Nat Rev Cancer. 2004 Feb;4(2):143-53 [14732866] Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):781-6 [14711994] Nature. 2004 Mar 18;428(6980):337-41 [15029199] Cell. 2004 Aug 20;118(4):409-18 [15315754] Hepatology. 2004 Sep;40(3):667-76 [15349906] Nat Rev Genet. 2004 Sep;5(9):691-701 [15372092] Nat Genet. 2004 Oct;36(10):1090-8 [15448693] Cancer Biol Ther. 2004 Jul;3(7):667-75 [15197354] Nature. 2004 Oct 28;431(7012):1112-7 [15475948] Cancer Res. 1968 Nov;28(11):2187-96 [5723963] Science. 1976 Oct 1;194(4260):23-8 [959840] Science. 1977 Jul 29;197(4302):461-3 [560061] Cancer Res. 1984 Jun;44(6):2259-65 [6372991] Cancer Treat Rep. 1985 Jun;69(6):615-32 [3893692] Med Hypotheses. 1986 Feb;19(2):103-12 [3634906] J Exp Med. 1996 Apr 1;183(4):1797-806 [8666936] Dig Liver Dis. 2008 Feb;40(2):114-21 [17920003] Cancer Cell. 2008 Feb;13(2):153-66 [18242515] Arch Surg. 2008 Feb;143(2):182-8; 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AN - 748976076; 20047800 AB - To compare the toxicity and efficacy of hypofractionated (62 Gy/20 fractions/5 weeks, 4 fractions per week) vs. conventional fractionation radiotherapy (80 Gy/40 fractions/8 weeks) in patients with high-risk prostate cancer. From January 2003 to December 2007, 168 patients were randomized to receive either hypofractionated or conventional fractionated schedules of three-dimensional conformal radiotherapy to the prostate and seminal vesicles. All patients received a 9-month course of total androgen deprivation (TAD), and radiotherapy started 2 months thereafter. The median (range) follow-up was 32 (8-66) and 35 (7-64) months in the hypofractionation and conventional fractionation arms, respectively. No difference was found for late toxicity between the two treatment groups, with 3-year Grade 2 rates of 17% and 16% for gastrointestinal and 14% and 11% for genitourinary in the hypofractionation and conventional fractionation groups, respectively. The 3-year freedom from biochemical failure (FFBF) rates were 87% and 79% in the hypofractionation and conventional fractionation groups, respectively (p = 0.035). The 3-year FFBF rates in patients at a very high risk (i.e., pretreatment prostate-specific antigen (iPSA) >20 ng/mL, Gleason score >or=8, or T >or=2c), were 88% and 76% (p = 0.014) in the former and latter arm, respectively. The multivariate Cox analysis confirmed fractionation, iPSA, and Gleason score as significant prognostic factors. Our findings suggest that late toxicity is equivalent between the two treatment groups and that the hypofractionated schedule used in this trial is superior to the conventional fractionation in terms of FFBF. Copyright (c) 2010 Elsevier Inc. All rights reserved. JF - International journal of radiation oncology, biology, physics AU - Arcangeli, Giorgio AU - Saracino, Biancamaria AU - Gomellini, Sara AU - Petrongari, Maria Grazia AU - Arcangeli, Stefano AU - Sentinelli, Steno AU - Marzi, Simona AU - Landoni, Valeria AU - Fowler, Jack AU - Strigari, Lidia AD - Department of Radiotherapy, Regina Elena National Cancer Institute, Rome, Italy. arcangeli@ifo.it Y1 - 2010/09/01/ PY - 2010 DA - 2010 Sep 01 SP - 11 EP - 18 VL - 78 IS - 1 KW - Androgen Antagonists KW - 0 KW - Anilides KW - Antineoplastic Agents KW - Nitriles KW - Tosyl Compounds KW - bicalutamide KW - A0Z3NAU9DP KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Index Medicus KW - Androgen Antagonists -- therapeutic use KW - Dose Fractionation KW - Radiation Injuries -- prevention & control KW - Humans KW - Seminal Vesicles -- radiation effects KW - Aged KW - Nitriles -- therapeutic use KW - Multivariate Analysis KW - Prospective Studies KW - Anilides -- therapeutic use KW - Prostate -- radiation effects KW - Aged, 80 and over KW - Prostate-Specific Antigen -- blood KW - Tosyl Compounds -- therapeutic use KW - Follow-Up Studies KW - Middle Aged KW - Antineoplastic Agents -- therapeutic use KW - Male KW - Prostatic Neoplasms -- pathology KW - Radiotherapy, Conformal -- methods KW - Prostatic Neoplasms -- drug therapy KW - Adenocarcinoma -- drug therapy KW - Prostatic Neoplasms -- radiotherapy KW - Adenocarcinoma -- radiotherapy KW - Radiotherapy, Conformal -- adverse effects KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748976076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=A+prospective+phase+III+randomized+trial+of+hypofractionation+versus+conventional+fractionation+in+patients+with+high-risk+prostate+cancer.&rft.au=Arcangeli%2C+Giorgio%3BSaracino%2C+Biancamaria%3BGomellini%2C+Sara%3BPetrongari%2C+Maria+Grazia%3BArcangeli%2C+Stefano%3BSentinelli%2C+Steno%3BMarzi%2C+Simona%3BLandoni%2C+Valeria%3BFowler%2C+Jack%3BStrigari%2C+Lidia&rft.aulast=Arcangeli&rft.aufirst=Giorgio&rft.date=2010-09-01&rft.volume=78&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=1879-355X&rft_id=info:doi/10.1016%2Fj.ijrobp.2009.07.1691 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-01 N1 - Date created - 2010-08-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Int J Radiat Oncol Biol Phys. 2011 May 1;80(1):316; author reply 316-7 [21481731] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ijrobp.2009.07.1691 ER - TY - JOUR T1 - Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier. AN - 748964615; 20547735 AB - ATP-driven efflux transporters at the blood-brain barrier both protect against neurotoxicants and limit drug delivery to the brain. In other barrier and excretory tissues, efflux transporter expression is regulated by certain ligand-activated nuclear receptors. Here we identified constitutive androstane receptor (CAR) as a positive regulator of P-glycoprotein, multidrug resistance-associated protein 2 (Mrp2), and breast cancer resistance protein (BCRP) expression in rat and mouse brain capillaries. Exposing rat brain capillaries to the CAR activator, phenobarbital (PB), increased the transport activity and protein expression (Western blots) of P-glycoprotein, Mrp2, and BCRP. Induction of transport was abolished by the protein phosphatase 2A inhibitor, OA. Similar effects on transporter activity and expression were found when mouse brain capillaries were exposed to the mouse-specific CAR ligand, 1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP). In brain capillaries from CAR-null mice, TCPOBOP did not increase transporter activity. Finally, treating mice with 0.33 mg/kg TCPOBOP or rats with 80 mg/kg PB increased P-glycoprotein-, Mrp2-, and BCRP-mediated transport and protein expression in brain capillaries assayed ex vivo. Thus, CAR activation selectively tightens the blood-brain barrier by increasing transport activity and protein expression of three xenobiotic efflux pumps. JF - Molecular pharmacology AU - Wang, Xueqian AU - Sykes, Destiny B AU - Miller, David S AD - Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 376 EP - 383 VL - 78 IS - 3 KW - Membrane Transport Proteins KW - 0 KW - Multidrug Resistance-Associated Proteins KW - P-Glycoprotein KW - Receptors, Cytoplasmic and Nuclear KW - Xenobiotics KW - constitutive androstane receptor KW - multidrug resistance-associated protein 2 KW - 4AF605U6JN KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Animals KW - Xenobiotics -- metabolism KW - Brain -- blood supply KW - Biological Transport -- genetics KW - Brain -- metabolism KW - Mice KW - Transcriptional Activation KW - Mice, Knockout KW - Rats KW - Rats, Sprague-Dawley KW - Phenobarbital -- pharmacology KW - P-Glycoprotein -- genetics KW - Phenobarbital -- metabolism KW - P-Glycoprotein -- metabolism KW - Up-Regulation -- drug effects KW - Multidrug Resistance-Associated Proteins -- metabolism KW - Multidrug Resistance-Associated Proteins -- genetics KW - Mice, Inbred C3H KW - Capillaries -- metabolism KW - Membrane Transport Proteins -- genetics KW - Membrane Transport Proteins -- metabolism KW - Male KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Blood-Brain Barrier -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748964615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Constitutive+androstane+receptor-mediated+up-regulation+of+ATP-driven+xenobiotic+efflux+transporters+at+the+blood-brain+barrier.&rft.au=Wang%2C+Xueqian%3BSykes%2C+Destiny+B%3BMiller%2C+David+S&rft.aulast=Wang&rft.aufirst=Xueqian&rft.date=2010-09-01&rft.volume=78&rft.issue=3&rft.spage=376&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=1521-0111&rft_id=info:doi/10.1124%2Fmol.110.063685 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-21 N1 - Date created - 2010-08-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Cereb Blood Flow Metab. 2008 Jun;28(6):1222-34 [18349876] Pharmacol Rev. 2008 Jun;60(2):196-209 [18560012] Toxicology. 2008 Oct 30;252(1-3):105-12 [18786598] J Neurochem. 2008 Dec;107(6):1518-28 [19094056] Br J Pharmacol. 2009 Jan;156(1):7-27 [19133988] Pharm Res. 2009 Feb;26(2):480-7 [18841445] BMC Genomics. 2009;10:384 [19691840] Neurobiol Dis. 2010 Jan;37(1):13-25 [19664713] Mol Pharmacol. 2000 Dec;58(6):1357-67 [11093774] Genes Dev. 2000 Dec 1;14(23):3014-23 [11114890] Mol Cell Biol. 2001 Apr;21(8):2838-46 [11283262] Mol Pharmacol. 2002 Jan;61(1):1-6 [11752199] J Biol Chem. 2002 Jan 25;277(4):2908-15 [11706036] Pharmacogenomics J. 2002;2(2):117-26 [12049174] Drug Metab Dispos. 2002 Aug;30(8):918-23 [12124310] Mol Cancer Ther. 2002 Apr;1(6):417-25 [12477054] Biochim Biophys Acta. 2003 Feb 17;1619(3):235-8 [12573482] FEBS Lett. 2003 Jul 31;548(1-3):17-20 [12885400] Curr Drug Metab. 2003 Dec;4(6):515-25 [14683479] Mol Pharmacol. 2004 Sep;66(3):387-94 [15322229] Mol Pharmacol. 2004 Sep;66(3):413-9 [15322232] J Pharmacol Exp Ther. 2004 Nov;311(2):811-21 [15194709] Am J Physiol. 1995 Jan;268(1 Pt 2):F46-52 [7840247] Mol Cell Biol. 1999 Sep;19(9):6318-22 [10454578] Arch Pharm Res. 2005 Mar;28(3):249-68 [15832810] Biol Chem. 2005 Jun;386(6):503-13 [16006237] FEBS Lett. 2005 Dec 19;579(30):6733-6 [16310787] Drug Metab Dispos. 2006 Mar;34(3):405-9 [16381673] Drug Metab Rev. 2006;38(3):515-97 [16877263] Drug Metab Dispos. 2006 Oct;34(10):1756-63 [16837569] Mol Pharmacol. 2006 Oct;70(4):1212-9 [16837625] Drug Metab Dispos. 2006 Dec;34(12):2003-10 [16936065] Steroids. 2007 Mar;72(3):231-46 [17284330] Neurochem Int. 2008 Mar-Apr;52(4-5):669-74 [17919779] Curr Neurovasc Res. 2008 May;5(2):82-92 [18473823] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/mol.110.063685 ER - TY - JOUR T1 - Pharmacokinetics of orally administered ABT-751 in children with neuroblastoma and other solid tumors. AN - 733982550; 20044751 AB - To describe the pharmacokinetics of orally administered ABT-751 and its conjugated metabolites in children with neuroblastoma and other solid tumors and to relate pharmacokinetic parameters to toxicity and therapeutic outcomes. Patients (median age, 11 years) with neuroblastoma (n = 37) or other solid tumors (n = 25) had pharmacokinetic sampling after the first dose of ABT-751 (75-250 mg/m(2)/day) on a 7-day or 21-day schedule. ABT-751 and its glucuronide and sulfate metabolites were quantified with an HPLC/MS/MS assay. Pharmacokinetic parameters were derived with non-compartmental methods. The relative bioavailability of more water soluble capsule and suspension formulations was assessed. ABT-751 peaked in plasma at 2 h and declined monoexponentially with a t (1/2) of 5.1 h. The apparent clearance was 33 ml/min/m(2) and was age-independent. The AUC(0-infinity) increased in proportion to the dose, and at 200 mg/m(2) the median AUC(0-infinity) was 91 mcg h/ml and the C (ave) was 3.9 mcg/ml. Inter-and intra-patient variability was low. The metabolites were detected in plasma 30 min post-dose and peaked 3-5 h after the dose. The glucuronide:sulfate molar AUC(0-infinity) ratio was 0.57. Less than 1% of the dose was excreted in urine as parent drug; 13% of the dose was excreted as sulfate metabolite and 10% as glucuronide metabolite. The relative bioavailability of the water soluble capsule and suspension formulations was 105 and 93%, respectively. AUC(0-infinity) was higher in patients experiencing dose-limiting toxicity. Oral ABT-751 pharmacokinetics was dose-proportional and age-independent with minimal intra- and inter-patient variability in children. JF - Cancer chemotherapy and pharmacology AU - Fox, Elizabeth AU - Maris, John M AU - Cohn, Susan L AU - Goodspeed, Wendy AU - Goodwin, Anne AU - Kromplewski, Marie AU - Medina, Diane AU - Xiong, Hao AU - Krivoshik, Andrew AU - Widemann, Brigitte AU - Adamson, Peter C AU - Balis, Frank M AD - Pediatric Oncology Branch, National Cancer Institute, 10 Center Drive, Bethesda, MD 20892-1101, USA. foxb@mail.nih.gov Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 737 EP - 743 VL - 66 IS - 4 KW - ABT751 KW - 0 KW - Glucuronides KW - Sulfates KW - Sulfonamides KW - Index Medicus KW - Sulfates -- metabolism KW - Mass Spectrometry KW - Area Under Curve KW - Dose-Response Relationship, Drug KW - Biotransformation KW - Humans KW - Treatment Outcome KW - Child KW - Neoplasm Recurrence, Local KW - Glucuronides -- metabolism KW - Adolescent KW - Male KW - Female KW - Chromatography, High Pressure Liquid KW - Child, Preschool KW - Sulfonamides -- pharmacokinetics KW - Neuroblastoma -- drug therapy KW - Sulfonamides -- therapeutic use KW - Neuroblastoma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733982550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Pharmacokinetics+of+orally+administered+ABT-751+in+children+with+neuroblastoma+and+other+solid+tumors.&rft.au=Fox%2C+Elizabeth%3BMaris%2C+John+M%3BCohn%2C+Susan+L%3BGoodspeed%2C+Wendy%3BGoodwin%2C+Anne%3BKromplewski%2C+Marie%3BMedina%2C+Diane%3BXiong%2C+Hao%3BKrivoshik%2C+Andrew%3BWidemann%2C+Brigitte%3BAdamson%2C+Peter+C%3BBalis%2C+Frank+M&rft.aulast=Fox&rft.aufirst=Elizabeth&rft.date=2010-09-01&rft.volume=66&rft.issue=4&rft.spage=737&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=1432-0843&rft_id=info:doi/10.1007%2Fs00280-009-1218-z LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-03 N1 - Date created - 2010-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00280-009-1218-z ER - TY - JOUR T1 - Cooperation of tumor-derived HBx mutants and p53-249(ser) mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line. AN - 733637993; 20017137 AB - Hepatocellular carcinoma (HCC) is a common cancer, and hepatitis B virus (HBV) is a major etiological agent. Convincing epidemiological and experimental evidence also links HCC to aflatoxin, a naturally occurring mycotoxin that produces a signature p53-249(ser) mutation. Recently, we have reported that tumor-derived HBx variants encoded by HBV exhibited attenuated transactivation and proapoptotic functions but retained their ability to block p53-mediated apoptosis. These results indicate that mutations in HBx may contribute to the development of HCC. In this study, we determined whether tumor-derived HBx mutants along, or in cooperation with p53-249(ser), could alter cell proliferation and chromosome stability of normal human hepatocytes. To test this hypothesis, we established a telomerase immortalized normal human hepatocycte line HHT4 that exhibited a near diploid karyotype and expressed many hepatocyte-specific genes. We found that overexpression one of the tumor-derived HBx mutants, CT, significantly increased colony forming efficiency (CFE) while its corresponding wild-type allele CNT significantly decreased CFE in HHT4 cells. p53-249(ser) rescued CNT-mediated inhibition of colony formation. Although HHT4 cells lacked an anchorage independent growth capability as they did not form any colonies in soft agar, the CT-expressing HHT4 cells could form colonies, which could be significantly enhanced by p53-249(ser). Induction of aneuploidy could be observed in HHT4 cells expressing CT, but additionally recurring chromosome abnormalities could only be detected in cells coexpressing CT and p53-249(ser). Our results are consistent with the hypothesis that certain mutations in HBx and p53 at codon 249 may cooperate in contributing to liver carcinogenesis. JF - International journal of cancer AU - Jiang, Weidong AU - Wang, Xin Wei AU - Unger, Tamar AU - Forgues, Marshonna AU - Kim, Jin Woo AU - Hussain, S Perwez AU - Bowman, Elise AU - Spillare, Elisa A AU - Lipsky, Michael M AU - Meck, Jeanne M AU - Cavalli, Luciane R AU - Haddad, Bassem R AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2010/09/01/ PY - 2010 DA - 2010 Sep 01 SP - 1011 EP - 1020 VL - 127 IS - 5 KW - Biomarkers KW - 0 KW - RNA, Messenger KW - TP53 protein, human KW - Trans-Activators KW - Tumor Suppressor Protein p53 KW - hepatitis B virus X protein KW - Telomerase KW - EC 2.7.7.49 KW - Index Medicus KW - Apoptosis KW - Oligonucleotide Array Sequence Analysis KW - Hepatitis B virus KW - Chromosome Banding KW - Humans KW - In Situ Hybridization, Fluorescence KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Cell Proliferation KW - Gene Expression Profiling KW - Blotting, Western KW - Cells, Cultured KW - Biomarkers -- metabolism KW - Colony-Forming Units Assay KW - Cell Transformation, Neoplastic KW - Spectral Karyotyping KW - Cell Adhesion KW - Trans-Activators -- metabolism KW - Aneuploidy KW - Trans-Activators -- genetics KW - Mutation -- genetics KW - Hepatocytes -- cytology KW - Tumor Suppressor Protein p53 -- genetics KW - Tumor Suppressor Protein p53 -- metabolism KW - Telomerase -- metabolism KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733637993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Cooperation+of+tumor-derived+HBx+mutants+and+p53-249%28ser%29+mutant+in+regulating+cell+proliferation%2C+anchorage-independent+growth+and+aneuploidy+in+a+telomerase-immortalized+normal+human+hepatocyte-derived+cell+line.&rft.au=Jiang%2C+Weidong%3BWang%2C+Xin+Wei%3BUnger%2C+Tamar%3BForgues%2C+Marshonna%3BKim%2C+Jin+Woo%3BHussain%2C+S+Perwez%3BBowman%2C+Elise%3BSpillare%2C+Elisa+A%3BLipsky%2C+Michael+M%3BMeck%2C+Jeanne+M%3BCavalli%2C+Luciane+R%3BHaddad%2C+Bassem+R%3BHarris%2C+Curtis+C&rft.aulast=Jiang&rft.aufirst=Weidong&rft.date=2010-09-01&rft.volume=127&rft.issue=5&rft.spage=1011&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.25118 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-13 N1 - Date created - 2010-07-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2001 Jun 21;20(28):3620-8 [11439325] Oncogene. 2001 Jan 4;20(1):16-23 [11244501] Mutat Res. 1999 Jul 16;428(1-2):187-96 [10517992] Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):380-4 [15734961] Carcinogenesis. 2005 May;26(5):867-74 [15471900] Oncogene. 2005 Jun 23;24(27):4340-8 [15806150] Nat Cell Biol. 2005 Aug;7(8):823-30 [16041368] Oncogene. 2007 Apr 2;26(15):2166-76 [17401425] J Biol Chem. 2008 Feb 1;283(5):2793-803 [18032378] Oncogene. 2008 May 29;27(24):3457-64 [18193091] Clin Cancer Res. 2008 Aug 15;14(16):5061-8 [18698024] Hepatology. 2008 Nov;48(5):1467-76 [18781669] FASEB J. 2002 Oct;16(12):1665-7 [12207007] Toxicology. 2002 Dec 27;181-182:43-7 [12505283] Carcinogenesis. 2003 Mar;24(3):363-9 [12663493] Nat Med. 2003 Apr;9(4):416-23 [12640447] Mol Cell Biol. 2003 Aug;23(15):5282-92 [12861014] J Hepatol. 2003 Aug;39(2):253-61 [12873823] Cell. 2003 Jul 25;114(2):241-53 [12887925] Virus Res. 2004 Jun 15;102(2):133-9 [15084395] Nucleic Acids Res. 2004;32(7):2202-13 [15107488] Cancer Res. 2004 Oct 15;64(20):7329-35 [15492253] In Vitro Cell Dev Biol. 1985 Mar;21(3 Pt 1):154-60 [4008431] Nature. 1991 Apr 4;350(6317):427-8 [1849234] Nature. 1991 May 23;351(6324):317-20 [2034275] J Natl Cancer Inst. 1992 Nov 4;84(21):1638-41 [1279184] Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5123-7 [7685115] Cancer Res. 1994 Apr 15;54(8):2064-8 [8174105] J Virol. 1996 Aug;70(8):5701-5 [8764092] Hepatology. 1996 Nov;24(5):1024-33 [8903370] Carcinogenesis. 1997 Jan;18(1):121-5 [9054598] Mol Carcinog. 1997 Jul;19(3):191-203 [9254886] J Gastroenterol Hepatol. 1997 Oct;12(9-10):S294-308 [9407350] Arch Toxicol Suppl. 1998;20:227-36 [9442296] Hum Genet. 1998 Nov;103(5):619-25 [9860306] J Biol Chem. 1999 Jan 22;274(4):2327-36 [9890999] J Hepatol. 1999 Jul;31(1):123-32 [10424292] Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3216-23 [18990765] Cancer Res. 2008 Dec 15;68(24):10341-8 [19074903] Diagn Mol Pathol. 2002 Sep;11(3):177-85 [12218458] Mutat Res. 2000 Jun 30;460(1):17-28 [10856831] Biochem Biophys Res Commun. 2000 Oct 5;276(3):885-92 [11027564] Oncogene. 1999 Aug 26;18(34):4848-59 [10490818] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.25118 ER - TY - JOUR T1 - Topology of the disulfide bonds in the antiviral lectin scytovirin AN - 1534812230; 19893286 AB - The antiviral lectin scytovirin (SVN) contains a total of five disulfide bonds in two structurally similar domains. Previous reports provided contradictory results on the disulfide pairing in each individual domain, and we have now re-examined the disulfide topology. N-terminal sequencing and mass spectrometry were used to analyze proteolytic fragments of native SVN obtained at acidic pH, yielding the assignment as Cys7-Cys55, Cys20-Cys32, Cys26-Cys38, Cys68-Cys80, and Cys74-Cys86. We also analyzed the N-terminal domain of SVN (SD1, residues 1-48) prepared by expression/oxidative folding of the recombinant protein and by chemical synthesis. The disulfide pairing in the chemically synthesized SD1 was forced into predetermined topologies: SD1A (Cys20-Cys26, Cys32-Cys38) or SD1B (Cys20-Cys32, Cys26-Cys38). The topology of native SVN was found to be in agreement with the SD1B and the one determined for the recombinant SD1 domain. Although the two synthetic forms of SD1 were distinct when subjected to chromatography, their antiviral properties were indistinguishable, having low nM activity against HIV. Tryptic fragments, the "cystine clusters" [Cys20-Cys32/Cys26-Cys38; SD1] and [Cys68-Cys80/Cys74-C-86; SD2], were found to undergo rapid disulfide interchange at pH 8. This interchange resulted in accumulation of artifactual fragments in alkaline pH digests that are structurally unrelated to the original topology, providing a rational explanation for the differences between the topology reported herein and the one reported earlier (Bokesh et al., Biochemistry 2003; 42:2578-2584). Our observations emphasize the fact that proteins such as SVN, with disulfide bonds in close proximity, require considerable precautions when being fragmented for the purpose of disulfide assignment. JF - Protein Science AU - Moulaei, Tinoush AU - Stuchlik, Olga AU - Reed, Matthew AU - Yuan, Weirong AU - Pohl, Jan AU - Lu, Wuyuan AU - Haugh-Krumpe, Lauren AU - O'Keefe, Barry R AU - Wlodawer, Alexander AD - Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, NCI-Frederick, Frederick, Maryland 21702-1201. Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1649 EP - 1661 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 19 IS - 9 SN - 0961-8368, 0961-8368 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - lectins KW - disulfides KW - disulfide interchange KW - protein domain KW - mass spectrometry KW - synthetic protein KW - Proteolysis KW - Protein folding KW - Human immunodeficiency virus KW - Chromatography KW - Disulfide bonds KW - Lectins KW - Antiviral activity KW - pH effects KW - Mass spectroscopy KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1534812230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=Topology+of+the+disulfide+bonds+in+the+antiviral+lectin+scytovirin&rft.au=Moulaei%2C+Tinoush%3BStuchlik%2C+Olga%3BReed%2C+Matthew%3BYuan%2C+Weirong%3BPohl%2C+Jan%3BLu%2C+Wuyuan%3BHaugh-Krumpe%2C+Lauren%3BO%27Keefe%2C+Barry+R%3BWlodawer%2C+Alexander&rft.aulast=Moulaei&rft.aufirst=Tinoush&rft.date=2010-09-01&rft.volume=19&rft.issue=9&rft.spage=1649&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/10.1002%2Fpro.445 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-01 N1 - Last updated - 2015-11-25 N1 - SubjectsTermNotLitGenreText - Proteolysis; Protein folding; Chromatography; Disulfide bonds; Lectins; Antiviral activity; pH effects; Mass spectroscopy; Human immunodeficiency virus DO - http://dx.doi.org/10.1002/pro.445 ER - TY - JOUR T1 - Analysis of cohort studies with multivariate and partially observed disease classification data AN - 1171861880; 16120331 AB - Complex diseases like cancers can often be classified into subtypes using various pathological and molecular traits of the disease. In this article, we develop methods for analysis of disease incidence in cohort studies incorporating data on multiple disease traits using a two-stage semiparametric Cox proportional hazards regression model that allows one to examine the heterogeneity in the effect of the covariates by the levels of the different disease traits. For inference in the presence of missing disease traits, we propose a generalization of an estimating equation approach for handling missing cause of failure in competing-risk data. We prove asymptotic unbiasedness of the estimating equation method under a general missing-at-random assumption and propose a novel influence-function-based sandwich variance estimator. The methods are illustrated using simulation studies and a real data application involving the Cancer Prevention Study II nutrition cohort. JF - Biometrika AU - Chatterjee, Nilanjan AU - Sinha, Samiran AU - Diver, WRyan AU - Feigelson, Heather Spencer AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health . Rockville, Maryland 20852, U.S.A. Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 683 EP - 698 VL - 97 IS - 3 SN - 1464-3510, 1464-3510 KW - Biotechnology and Bioengineering Abstracts KW - Cancer KW - Classification KW - Data processing KW - Mathematical models KW - Models KW - Nutrition KW - Regression analysis KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1171861880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrika&rft.atitle=Analysis+of+cohort+studies+with+multivariate+and+partially+observed+disease+classification+data&rft.au=Chatterjee%2C+Nilanjan%3BSinha%2C+Samiran%3BDiver%2C+WRyan%3BFeigelson%2C+Heather+Spencer&rft.aulast=Chatterjee&rft.aufirst=Nilanjan&rft.date=2010-09-01&rft.volume=97&rft.issue=3&rft.spage=683&rft.isbn=&rft.btitle=&rft.title=Biometrika&rft.issn=14643510&rft_id=info:doi/10.1093%2Fbiomet%2Fasq036 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-11-01 N1 - Last updated - 2012-12-03 N1 - SubjectsTermNotLitGenreText - Mathematical models; Data processing; Classification; Regression analysis; Nutrition; Cancer; Models DO - http://dx.doi.org/10.1093/biomet/asq036 ER - TY - JOUR T1 - Endurance exercise training in myostatin null mice AN - 1020848045; 15258708 AB - The growth factor myostatin (Mstn) is a negative regulator of skeletal muscle mass. Mstn-/- muscles are hypertrophied, stronger, and more glycolytic than Mstn+/+ muscles, suggesting that they might not perform endurance exercise as well as Mstn+/+ mice. Indeed, it has previously been shown that treadmill exercise training reduces triceps weight in Mstn-/- mice. To analyze the response of Mstn-/- muscle to endurance exercise in detail, we carried out endurance training over 4 weeks to examine muscle mass, histology, and oxidative enzyme activity. We found that muscle mass was reduced with training in several muscles from both genotypes, with no evidence of muscle damage. Citrate synthase activity was increased with training in control and mutant mice. Non-trained Mstn-/- mice did, however, have lower maximal exercise capacity compared with Mstn+/+ mice. These results show that Mstn-/- muscle retains the metabolic plasticity necessary to adapt normally to endurance training. Muscle Nerve, 2010 JF - Muscle & Nerve AU - Savage, Kathleen J AU - McPherron, Alexandra C Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 355 EP - 362 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA, [mailto:info@wiley.com], [URL:http://www.wiley.com/WileyCDA/Brand/id-35.html] VL - 42 IS - 3 SN - 0148-639X, 0148-639X KW - Physical Education Index KW - Muscles (size) KW - Muscular endurance KW - Muscles (exercise effects) KW - Exercise (intensity) KW - Animal subjects KW - Muscles KW - Endurance KW - Muscles (activity) KW - Exercise (programs) KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020848045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Muscle+%26+Nerve&rft.atitle=Endurance+exercise+training+in+myostatin+null+mice&rft.au=Savage%2C+Kathleen+J%3BMcPherron%2C+Alexandra+C&rft.aulast=Savage&rft.aufirst=Kathleen&rft.date=2010-09-01&rft.volume=42&rft.issue=3&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Muscle+%26+Nerve&rft.issn=0148639X&rft_id=info:doi/10.1002%2Fmus.21688 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mus.21688/abstract LA - English DB - Physical Education Index N1 - Date revised - 2012-06-01 N1 - Last updated - 2013-12-04 N1 - SubjectsTermNotLitGenreText - Muscular endurance; Muscles (size); Exercise (intensity); Muscles (exercise effects); Animal subjects; Muscles; Endurance; Muscles (activity); Exercise (programs) DO - http://dx.doi.org/10.1002/mus.21688 ER - TY - JOUR T1 - Nanoparticle-based theranostic agents AN - 869585348; 14816584 AB - Theranostic nanomedicine is emerging as a promising therapeutic paradigm. It takes advantage of the high capacity of nanoplatforms to ferry cargo and loads onto them both imaging and therapeutic functions. The resulting nanosystems, capable of diagnosis, drug delivery and monitoring of therapeutic response, are expected to play a significant role in the dawning era of personalized medicine, and much research effort has been devoted toward that goal. A convenience in constructing such function-integrated agents is that many nanoplatforms are already, themselves, imaging agents. Their well-developed surface chemistry makes it easy to load them with pharmaceutics and promote them to be theranostic nanosystems. Iron oxide nanoparticles, quantum dots, carbon nanotubes, gold nanoparticles and silica nanoparticles, have been previously well investigated in the imaging setting and are candidate nanoplatforms for building up nanoparticle-based theranostics. In the current article, we will outline the progress along this line, organized by the category of the core materials. We will focus on construction strategies and will discuss the challenges and opportunities associated with this emerging technology. JF - Advanced Drug Delivery Reviews AU - Xie, Jin AU - Lee, Seulki AU - Chen, Xiaoyuan AD - Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 31 Center Dr, Suite 1C14, Bethesda, MD 20892-2281, USA Y1 - 2010/08/30/ PY - 2010 DA - 2010 Aug 30 SP - 1064 EP - 1079 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 62 IS - 11 SN - 0169-409X, 0169-409X KW - Biotechnology and Bioengineering Abstracts KW - Theranostics KW - Drug delivery KW - Gene delivery KW - Nanomedicine KW - Molecular imaging KW - Iron oxide nanoparticles KW - Quantum dots KW - Gold nanoparticles KW - Carbon nanotubes KW - Silica nanoparticles KW - Carbon KW - Silica KW - iron oxides KW - Construction KW - nanotubes KW - Gold KW - imaging KW - nanoparticles KW - nanotechnology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869585348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Drug+Delivery+Reviews&rft.atitle=Nanoparticle-based+theranostic+agents&rft.au=Xie%2C+Jin%3BLee%2C+Seulki%3BChen%2C+Xiaoyuan&rft.aulast=Xie&rft.aufirst=Jin&rft.date=2010-08-30&rft.volume=62&rft.issue=11&rft.spage=1064&rft.isbn=&rft.btitle=&rft.title=Advanced+Drug+Delivery+Reviews&rft.issn=0169409X&rft_id=info:doi/10.1016%2Fj.addr.2010.07.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Drug delivery; Silica; Carbon; iron oxides; Construction; Quantum dots; Gold; nanotubes; nanoparticles; imaging; nanotechnology DO - http://dx.doi.org/10.1016/j.addr.2010.07.009 ER - TY - JOUR T1 - DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. AN - 749016868; 20733034 AB - Aberrant DNA methylation commonly occurs in cancer cells where it has been implicated in the epigenetic silencing of tumor suppressor genes. Additional roles for DNA methylation, such as transcriptional activation, have been predicted but have yet to be clearly demonstrated. The BCL6 oncogene is implicated in the pathogenesis of germinal center-derived B cell lymphomas. We demonstrate that the intragenic CpG islands within the first intron of the human BCL6 locus were hypermethylated in lymphoma cells that expressed high amounts of BCL6 messenger RNA (mRNA). Inhibition of DNA methyltransferases decreased BCL6 mRNA abundance, suggesting a role for these methylated CpGs in positively regulating BCL6 transcription. The enhancer-blocking transcription factor CTCF bound to this intronic region in a methylation-sensitive manner. Depletion of CTCF by short hairpin RNA in neoplastic plasma cells that do not express BCL6 resulted in up-regulation of BCL6 transcription. These data indicate that BCL6 expression is maintained during lymphomagenesis in part through DNA methylation that prevents CTCF-mediated silencing. JF - The Journal of experimental medicine AU - Lai, Anne Y AU - Fatemi, Mehrnaz AU - Dhasarathy, Archana AU - Malone, Christine AU - Sobol, Steve E AU - Geigerman, Cissy AU - Jaye, David L AU - Mav, Deepak AU - Shah, Ruchir AU - Li, Leping AU - Wade, Paul A AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2010/08/30/ PY - 2010 DA - 2010 Aug 30 SP - 1939 EP - 1950 VL - 207 IS - 9 KW - BCL6 protein, human KW - 0 KW - CCCTC-binding factor KW - DNA-Binding Proteins KW - Proto-Oncogene Proteins c-bcl-6 KW - Repressor Proteins KW - Index Medicus KW - Oncogenes KW - Humans KW - CpG Islands KW - Introns KW - Transcription, Genetic KW - Cell Line, Tumor KW - Protein Binding KW - DNA Methylation KW - Repressor Proteins -- metabolism KW - DNA-Binding Proteins -- genetics KW - Lymphoma, B-Cell -- genetics KW - Repressor Proteins -- genetics KW - Lymphoma, B-Cell -- metabolism KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/749016868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+experimental+medicine&rft.atitle=DNA+methylation+prevents+CTCF-mediated+silencing+of+the+oncogene+BCL6+in+B+cell+lymphomas.&rft.au=Lai%2C+Anne+Y%3BFatemi%2C+Mehrnaz%3BDhasarathy%2C+Archana%3BMalone%2C+Christine%3BSobol%2C+Steve+E%3BGeigerman%2C+Cissy%3BJaye%2C+David+L%3BMav%2C+Deepak%3BShah%2C+Ruchir%3BLi%2C+Leping%3BWade%2C+Paul+A&rft.aulast=Lai&rft.aufirst=Anne&rft.date=2010-08-30&rft.volume=207&rft.issue=9&rft.spage=1939&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+experimental+medicine&rft.issn=1540-9538&rft_id=info:doi/10.1084%2Fjem.20100204 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-16 N1 - Date created - 2010-08-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Blood. 1995 Jul 1;86(1):28-37 [7795234] Blood. 1995 Jul 1;86(1):45-53 [7795255] Mol Cell Biol. 1996 Jun;16(6):2802-13 [8649389] Nat Genet. 1997 Jun;16(2):161-70 [9171827] J Biol Chem. 1998 Mar 6;273(10):5858-68 [9488723] Novartis Found Symp. 1998;214:187-95; 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14142857 AB - Destructive midline granulomatous disease characterized by necrotizing granulomas of the head and neck is most commonly caused by Wegener granulomatosis, natural killer/T-cell lymphomas, cocaine abuse, or infections. An adolescent patient with myasthenia gravis treated with thymectomy subsequently developed extensive granulomatous destruction of midface structures, palate, nasal septum, airways, and epiglottis. His lymphocyte numbers, total immunoglobulin G level, and T-cell receptor (TCR) repertoire appeared normal. Sequencing of Recombination activating gene-1 (Rag1) showed compound heterozygous Rag1 mutations; a novel deletion with no recombinase activity and a missense mutation resulting in 50% Rag activity. His thymus was dysplastic and, although not depleted of T cells, showed a notable absence of autoimmune regulator (AIRE) and Foxp3+ regulatory T cells. This distinct Rag-deficient phenotype characterized by immune dysregulation with granulomatous hyperinflammation and autoimmunity, with relatively normal T and B lymphocyte numbers and a diverse TCR repertoire expands the spectrum of presentation in Rag deficiency. This study was registered at www.clinicaltrials.gov as #NCT00128973. JF - Blood AU - De Ravin, Suk See AU - Cowen, Edward W AU - Zarember, Kol A AU - Whiting-Theobald, Narda L AU - Kuhns, Douglas B AU - Sandler, Netanya G AU - Douek, Daniel C AU - Pittaluga, Stefania AU - Poliani, Pietro L AU - Lee, Yu Nee AU - Notarangelo, Luigi D AU - Wang, Lei AU - Alt, Frederick W AU - Kang, Elizabeth M AU - Milner, Joshua D AU - Niemela, Julie E AU - Fontana-Penn, Mary AU - Sinal, Sara H AU - Malech, Harry L AD - Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases and Dermatology Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD Y1 - 2010/08/26/ PY - 2010 DA - 2010 Aug 26 SP - 1263 EP - 1271 PB - The American Society of Hematology VL - 116 IS - 8 SN - 1528-0020, 1528-0020 KW - Toxicology Abstracts KW - Immunoregulation KW - recombinase KW - Autoimmunity KW - Drug abuse KW - Infection KW - Palate KW - RAG1 protein KW - Epiglottis KW - Recombination KW - Gene deletion KW - Foxp3 protein KW - Lymphocytes T KW - Septum KW - Cocaine KW - Head and neck KW - Respiratory tract KW - Granulomatosis KW - Missense mutation KW - Lymphocytes B KW - double prime T-cell receptor KW - Adolescence KW - Thymectomy KW - Thymus KW - Granuloma KW - AIRE protein KW - Blood KW - Myasthenia gravis KW - double prime T-cell lymphoma KW - Immunoglobulin G KW - Neuromuscular junctions KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876225373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Hypomorphic+Rag+mutations+can+cause+destructive+midline+granulomatous+disease&rft.au=De+Ravin%2C+Suk+See%3BCowen%2C+Edward+W%3BZarember%2C+Kol+A%3BWhiting-Theobald%2C+Narda+L%3BKuhns%2C+Douglas+B%3BSandler%2C+Netanya+G%3BDouek%2C+Daniel+C%3BPittaluga%2C+Stefania%3BPoliani%2C+Pietro+L%3BLee%2C+Yu+Nee%3BNotarangelo%2C+Luigi+D%3BWang%2C+Lei%3BAlt%2C+Frederick+W%3BKang%2C+Elizabeth+M%3BMilner%2C+Joshua+D%3BNiemela%2C+Julie+E%3BFontana-Penn%2C+Mary%3BSinal%2C+Sara+H%3BMalech%2C+Harry+L&rft.aulast=De+Ravin&rft.aufirst=Suk&rft.date=2010-08-26&rft.volume=116&rft.issue=8&rft.spage=1263&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=15280020&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Immunoregulation; recombinase; Autoimmunity; Infection; Drug abuse; Palate; RAG1 protein; Recombination; Epiglottis; Gene deletion; Foxp3 protein; Lymphocytes T; Septum; Cocaine; Head and neck; Respiratory tract; Granulomatosis; Missense mutation; Lymphocytes B; Thymectomy; Adolescence; double prime T-cell receptor; Thymus; Granuloma; Blood; AIRE protein; double prime T-cell lymphoma; Myasthenia gravis; Neuromuscular junctions; Immunoglobulin G ER - TY - JOUR T1 - Differential effects of smoking on lung cancer mortality before and after household stove improvement in Xuanwei, China AN - 754901983; 13553782 AB - Background:In Xuanwei County, Yunnan Province, China, lung cancer mortality rates in both males and females are among the highest in China. Methods:We evaluated differential effects of smoking on lung cancer mortality before and after household stove improvement with chimney to reduce exposure to smoky coal emissions in the unique cohort in Xuanwei, China. Effects of independent variables on lung cancer mortality were measured as hazard ratios and 95% confidence intervals using a multivariable Cox regression model that included separate time-dependent variables for smoking duration (years) before and after stove improvement.Results and conclusion:We found that the effect of smoking on lung cancer risk becomes considerably stronger after chimney installation and consequent reduction of indoor coal smoke exposure. JF - British Journal of Cancer AU - Lee, K-M AU - Chapman, R S AU - Shen, M AU - Lubin, J H AU - Silverman, D T AU - He, X AU - Hosgood, H D AU - Chen, B E AU - Rajaraman, P AU - Caporaso, N E AU - Fraumeni, J F AU - Blair, A AU - Lan, Q AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA Y1 - 2010/08/24/ PY - 2010 DA - 2010 Aug 24 SP - 727 EP - 729 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 103 IS - 5 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Mortality KW - Coal KW - Cancer KW - China, People's Rep., Yunnan Prov. KW - Smoke KW - Smoking KW - households KW - Emissions KW - Lung cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754901983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Differential+effects+of+smoking+on+lung+cancer+mortality+before+and+after+household+stove+improvement+in+Xuanwei%2C+China&rft.au=Lee%2C+K-M%3BChapman%2C+R+S%3BShen%2C+M%3BLubin%2C+J+H%3BSilverman%2C+D+T%3BHe%2C+X%3BHosgood%2C+H+D%3BChen%2C+B+E%3BRajaraman%2C+P%3BCaporaso%2C+N+E%3BFraumeni%2C+J+F%3BBlair%2C+A%3BLan%2C+Q&rft.aulast=Lee&rft.aufirst=K-M&rft.date=2010-08-24&rft.volume=103&rft.issue=5&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605791 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Smoke; Mortality; Smoking; households; Emissions; Coal; Cancer; Lung cancer; China, People's Rep., Yunnan Prov. DO - http://dx.doi.org/10.1038/sj.bjc.6605791 ER - TY - CPAPER T1 - Aging of Hearts and Arteries is Risky T2 - 2010 Gordon Research Conference on Aging, Biology Of AN - 754207032; 5775381 JF - 2010 Gordon Research Conference on Aging, Biology Of AU - Lakatta, Edward Y1 - 2010/08/22/ PY - 2010 DA - 2010 Aug 22 KW - Aging KW - Arteries KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754207032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Aging%2C+Biology+Of&rft.atitle=Aging+of+Hearts+and+Arteries+is+Risky&rft.au=Lakatta%2C+Edward&rft.aulast=Lakatta&rft.aufirst=Edward&rft.date=2010-08-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Aging%2C+Biology+Of&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=aging LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Metabolic regulation by SIRT1 T2 - 2010 Gordon Research Conference on Aging, Biology Of AN - 754205314; 5775358 JF - 2010 Gordon Research Conference on Aging, Biology Of AU - Li, Xiaoling Y1 - 2010/08/22/ PY - 2010 DA - 2010 Aug 22 KW - SIRT1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754205314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Aging%2C+Biology+Of&rft.atitle=Metabolic+regulation+by+SIRT1&rft.au=Li%2C+Xiaoling&rft.aulast=Li&rft.aufirst=Xiaoling&rft.date=2010-08-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Aging%2C+Biology+Of&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=aging LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Nitrogen-bound diazeniumdiolated amidines. AN - 748925812; 20589293 AB - In contrast to amidines bearing ionizable alpha-CH bonds, which react with nitric oxide (NO) to add diazeniumdiolate groups at their alpha-carbons, benzamidine forms an N-bound diazeniumdiolate that can be further derivatized at the other amidine nitrogen and/or the terminal oxygen to form caged NO compounds as potential NO prodrugs. JF - Chemical communications (Cambridge, England) AU - Biswas, Debanjan AU - Deschamps, Jeffrey R AU - Keefer, Larry K AU - Hrabie, Joseph A AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA. biswasd@mail.nih.gov Y1 - 2010/08/21/ PY - 2010 DA - 2010 Aug 21 SP - 5799 EP - 5801 VL - 46 IS - 31 KW - Amidines KW - 0 KW - Azo Compounds KW - Prodrugs KW - diazeniumdiolate KW - Nitric Oxide KW - 31C4KY9ESH KW - Nitrogen KW - N762921K75 KW - Index Medicus KW - Prodrugs -- chemistry KW - Nitric Oxide -- chemistry KW - Molecular Conformation KW - Prodrugs -- chemical synthesis KW - Nitrogen -- chemistry KW - Amidines -- chemistry KW - Azo Compounds -- chemistry KW - Amidines -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748925812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+communications+%28Cambridge%2C+England%29&rft.atitle=Nitrogen-bound+diazeniumdiolated+amidines.&rft.au=Biswas%2C+Debanjan%3BDeschamps%2C+Jeffrey+R%3BKeefer%2C+Larry+K%3BHrabie%2C+Joseph+A&rft.aulast=Biswas&rft.aufirst=Debanjan&rft.date=2010-08-21&rft.volume=46&rft.issue=31&rft.spage=5799&rft.isbn=&rft.btitle=&rft.title=Chemical+communications+%28Cambridge%2C+England%29&rft.issn=1364-548X&rft_id=info:doi/10.1039%2Fc0cc00849d LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-03 N1 - Date created - 2010-07-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1039/c0cc00849d ER - TY - JOUR T1 - Proline metabolism and microenvironmental stress. AN - 734000036; 20415579 AB - Proline, the only proteinogenic secondary amino acid, is metabolized by its own family of enzymes responding to metabolic stress and participating in metabolic signaling. Collagen in extracellular matrix, connective tissue, and bone is an abundant reservoir for proline. Matrix metalloproteinases degrading collagen are activated during stress to make proline available, and proline oxidase, the first enzyme in proline degradation, is induced by p53, peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligands, and by AMP-activated protein kinase downregulating mTOR. Metabolism of proline generates electrons to produce ROS and initiates a variety of downstream effects, including blockade of the cell cycle, autophagy, and apoptosis. The electrons can also enter the electron transport chain to produce adenosine triphosphate for survival under nutrient stress. Pyrroline-5-carboxylate, the product of proline oxidation, is recycled back to proline with redox transfers or is sequentially converted to glutamate and alpha-ketoglutarate. The latter augments the prolyl hydroxylation of hypoxia-inducible factor-1alpha and its proteasomal degradation. These effects of proline oxidase, as well as its decreased levels in tumors, support its role as a tumor suppressor. The mechanism for its decrease is mediated by a specific microRNA. The metabolic signaling by proline oxidase between oxidized low-density lipoproteins and autophagy provides a functional link between obesity and increased cancer risk. JF - Annual review of nutrition AU - Phang, James M AU - Liu, Wei AU - Zabirnyk, Olga AD - Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, Center for Cancer Research, NCI at Frederick, Frederick, Maryland 21702, USA. phangj@mail.nih.gov Y1 - 2010/08/21/ PY - 2010 DA - 2010 Aug 21 SP - 441 EP - 463 VL - 30 KW - Intracellular Signaling Peptides and Proteins KW - 0 KW - PPAR gamma KW - Reactive Oxygen Species KW - Tumor Suppressor Protein p53 KW - Collagen KW - 9007-34-5 KW - Proline KW - 9DLQ4CIU6V KW - Proline Oxidase KW - EC 1.5.3.- KW - MTOR protein, human KW - EC 2.7.1.1 KW - TOR Serine-Threonine Kinases KW - AMP-Activated Protein Kinases KW - EC 2.7.11.1 KW - Protein-Serine-Threonine Kinases KW - Matrix Metalloproteinases KW - EC 3.4.24.- KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Protein-Serine-Threonine Kinases -- metabolism KW - Intracellular Signaling Peptides and Proteins -- metabolism KW - AMP-Activated Protein Kinases -- metabolism KW - Humans KW - Apoptosis -- physiology KW - PPAR gamma -- metabolism KW - Tumor Suppressor Protein p53 -- metabolism KW - Autophagy -- physiology KW - Signal Transduction KW - Proline -- metabolism KW - Gene Expression Regulation, Enzymologic KW - Collagen -- metabolism KW - Proline Oxidase -- metabolism KW - Matrix Metalloproteinases -- metabolism KW - Proline Oxidase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734000036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+review+of+nutrition&rft.atitle=Proline+metabolism+and+microenvironmental+stress.&rft.au=Phang%2C+James+M%3BLiu%2C+Wei%3BZabirnyk%2C+Olga&rft.aulast=Phang&rft.aufirst=James&rft.date=2010-08-21&rft.volume=30&rft.issue=&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=Annual+review+of+nutrition&rft.issn=1545-4312&rft_id=info:doi/10.1146%2Fannurev.nutr.012809.104638 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-04 N1 - Date created - 2010-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1146/annurev.nutr.012809.104638 ER - TY - JOUR T1 - Low-Field Magnetic Resonance Imaging to Visualize Chronic and Cycling Hypoxia in Tumor-Bearing Mice AN - 877593437; 13651122 AB - Tumors exhibit fluctuations in blood flow that influence oxygen concentrations and therapeutic resistance. To assist therapeutic planning and improve prognosis, noninvasive dynamic imaging of spatial and temporal variations in oxygen partial pressure (pO2) would be useful. Here, we illustrate the use of pulsed electron paramagnetic resonance imaging (EPRI) as a novel imaging method to directly monitor fluctuations in oxygen concentrations in mouse models. A common resonator platform for both EPRI and magnetic resonance imaging (MRI) provided pO2 maps with anatomic guidance and microvessel density. Oxygen images acquired every 3 minutes for a total of 30 minutes in two different tumor types revealed that fluctuation patterns in pO2 are dependent on tumor size and tumor type. The magnitude of fluctuations in pO2 in SCCVII tumors ranged between 2- to 18-fold, whereas the fluctuations in HT29 xenografts were of lower magnitude. Alternating breathing cycles with air or carbogen (95% O2 plus 5% CO2) distinguished higher and lower sensitivity regions, which responded to carbogen, corresponding to cycling hypoxia and chronic hypoxia, respectively. Immunohistochemical analysis suggests that the fluctuation in pO2 correlated with pericyte density rather than vascular density in the tumor. This EPRI technique, combined with MRI, may offer a powerful clinical tool to noninvasively detect variable oxygenation in tumors. Cancer Res; 70(16); 6427-36. [copy ]2010 AACR. JF - Cancer Research AU - Yasui, Hironobu AU - Matsumoto, Shingo AU - Devasahayam, Nallathamby AU - Munasinghe, Jeeva P AU - Choudhuri, Rajani AU - Saito, Keita AU - Subramanian, Sankaran AU - Mitchell, James B AU - Krishna, Murali C AD - Authors' Affiliations: Radiation Biology Branch, Center for Cancer Research, National Cancer Institute and National Institute of Neurological Disorder and Stroke, NIH, Bethesda, Maryland Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 6427 EP - 6436 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 70 IS - 16 SN - 0008-5472, 0008-5472 KW - Toxicology Abstracts KW - E.S.R. KW - Temporal variations KW - Respiration KW - Magnetic resonance imaging KW - Animal models KW - Prognosis KW - pericytes KW - Tumors KW - Maps KW - Cancer KW - Oxygen KW - Hypoxia KW - Xenografts KW - Carbon dioxide KW - Pressure KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877593437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Low-Field+Magnetic+Resonance+Imaging+to+Visualize+Chronic+and+Cycling+Hypoxia+in+Tumor-Bearing+Mice&rft.au=Yasui%2C+Hironobu%3BMatsumoto%2C+Shingo%3BDevasahayam%2C+Nallathamby%3BMunasinghe%2C+Jeeva+P%3BChoudhuri%2C+Rajani%3BSaito%2C+Keita%3BSubramanian%2C+Sankaran%3BMitchell%2C+James+B%3BKrishna%2C+Murali+C&rft.aulast=Yasui&rft.aufirst=Hironobu&rft.date=2010-08-15&rft.volume=70&rft.issue=16&rft.spage=6427&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - E.S.R.; Temporal variations; Respiration; Magnetic resonance imaging; Prognosis; Animal models; pericytes; Tumors; Maps; Cancer; Oxygen; Hypoxia; Xenografts; Pressure; Carbon dioxide ER - TY - JOUR T1 - Ontogenomic study of the relationship between number of gene splice variants and GO categorization AN - 787194701; 13654076 AB - Motivation: Splice variation plays important roles in evolution and cancer. Different splice variants of a gene may be characteristic of particular cellular processes, subcellular locations or organs. Although several genomic projects have identified splice variants, there have been no large-scale computational studies of the relationship between number of splice variants and biological function. The Gene Ontology (GO) and tools for leveraging GO, such as GoMiner, now make such a study feasible.Results: We partitioned genes into two groups: those with numbers of splice variants ,b and >b (b=1,..., 10). Then we used GoMiner to determine whether any GO categories are enriched in genes with particular numbers of splice variants. Since there was no a priori 'appropriate' partition boundary, we studied those 'robust' categories whose enrichment did not depend on the selection of a particular partition boundary. Furthermore, because the distribution of splice variant number was a snapshot taken at a particular point in time, we confirmed that those observations were stable across successive builds of GenBank. A small number of categories were found for genes in the lower partitions. A larger number of categories were found for genes in the higher partitions. Those categories were largely associated with cell death and signal transduction. Apoptotic genes tended to have a large repertoire of splice variants, and genes with splice variants exhibited a distinctive 'apoptotic island' in clustered image maps (CIMs).Availability: Supplementary tables and figures are available at URL http://discover.nci.nih.gov/OG/supplementaryMaterials.html. The Safari browser appears to perform better than Firefox for these particular items.Contact: barry sub(i)scover.nci.nih.gov JF - Bioinformatics AU - Kahn, Ari B AU - Zeeberg, Barry R AU - Ryan, Michael C AU - Jamison, DCurtis AU - Rockoff, David M AU - Pommier, Yves AU - Weinstein, John N AD - super(1)Department of Bioinformatics, George Mason University, Fairfax, VA, super(2)Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD, super(3)SRA International, Inc., super(4)Tiger Team Consulting, Fairfax, VA, super(5)Department of Biomedical Informatics, Cincinnati Children's Hospital, Cincinnati, OH, super(6)Department of Statistics, Iowa State University, Ames, IA and super(7)Department of Bioinformatics and Computational Biology, M. D. Anderson Cancer Center, Houston, TX, USA Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 1945 EP - 1949 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 26 IS - 16 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Cell death KW - Apoptosis KW - Islands KW - Boundaries KW - Bioinformatics KW - genomics KW - Computer applications KW - Cancer KW - Alternative splicing KW - Signal transduction KW - Gene mapping KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/787194701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Ontogenomic+study+of+the+relationship+between+number+of+gene+splice+variants+and+GO+categorization&rft.au=Kahn%2C+Ari+B%3BZeeberg%2C+Barry+R%3BRyan%2C+Michael+C%3BJamison%2C+DCurtis%3BRockoff%2C+David+M%3BPommier%2C+Yves%3BWeinstein%2C+John+N&rft.aulast=Kahn&rft.aufirst=Ari&rft.date=2010-08-15&rft.volume=26&rft.issue=16&rft.spage=1945&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtq335 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Cell death; Islands; Apoptosis; Boundaries; genomics; Bioinformatics; Computer applications; Cancer; Gene mapping; Signal transduction; Alternative splicing DO - http://dx.doi.org/10.1093/bioinformatics/btq335 ER - TY - JOUR T1 - Electrical percolation-based biosensor for real-time direct detection of staphylococcal enterotoxin B (SEB) AN - 760196882; 13070547 AB - Electrical percolation-based biosensing is a new technology. This is the first report of an electrical percolation-based biosensor for real-time detection. The label-free biosensor is based on electrical percolation through a single-walled carbon nanotubes (SWNTs)-antibody complex that forms a network functioning as a "Biological Semiconductor" (BSC). The conductivity of a BSC is directly related to the number of contacts facilitated by the antibody-antigen "connectors" within the SWNT network. BSCs are fabricated by immobilizing a pre-functionalized SWNTs-antibody complex directly on a poly(methyl methacrylate) (PMMA) and polycarbonate (PC) surface. Each BSC is connected via silver electrodes to a computerized ohmmeter, thereby enabling a continuous electronic measurement of molecular interactions (e.g. antibody-antigen binding) via the change in resistance. Using anti-staphylococcal enterotoxin B (SEB) IgG to functionalize the BSC, we demonstrate that the biosensor was able to detect SEB at concentrations as low as 5ng/mL at a signal to baseline (S/B) ratio of 2. Such measurements were performed on the chip in wet conditions. The actuation of the chip by SEB is immediate, permitting real-time signal measurements. In addition to this "direct" label-free detection mode, a secondary antibody can be used to "label" the target molecule bound to the BSC in a manner analogous to an immunological sandwich "indirect" detection-type assay. Although a secondary antibody is not needed for direct detection, the indirect mode of detection may be useful as an additional measurement to verify or amplify signals from direct detection in clinical, food safety and other critical assays. The BSC was used to measure SEB both in buffer and in milk, a complex matrix, demonstrating the potential of electrical percolation-based biosensors for real-time label-free multi-analyte detection in clinical and complex samples. Assembly of BSCs is simple enough that multiple sensors can be fabricated on the same chip, thereby creating "Biological Central Processing Units (BCPUs)" capable of parallel processing and sorting out information on multiple analytes simultaneously which may be used for complex analysis and for point of care diagnostics. JF - Biosensors and Bioelectronics AU - Yang, Minghui AU - Sun, Steven AU - Bruck, Hugh Alan AU - Kostov, Yordan AU - Rasooly, Avraham AD - Center for Advanced Sensor Technology, University of Maryland, Baltimore County, MD 21250, United States, rasoolya@mail.nih.gov Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 2573 EP - 2578 PB - Elsevier Advanced Technology, 660 White Plains Rd. Tarrytown NY 10591-5153 USA VL - 25 IS - 12 SN - 0956-5663, 0956-5663 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Biosensor KW - Semiconductor KW - Carbon nanotubes KW - Electrical percolation KW - Antibody KW - Point of care KW - Personalized medicine KW - Milk KW - Food KW - Staphylococcal enterotoxin B KW - Biosensors KW - Carbon KW - integrated circuits KW - Electrodes KW - Immunoglobulin G KW - nanotubes KW - polymethylmethacrylate KW - Silver KW - enterotoxin B KW - polycarbonate KW - W 30955:Biosensors KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760196882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosensors+and+Bioelectronics&rft.atitle=Electrical+percolation-based+biosensor+for+real-time+direct+detection+of+staphylococcal+enterotoxin+B+%28SEB%29&rft.au=Yang%2C+Minghui%3BSun%2C+Steven%3BBruck%2C+Hugh+Alan%3BKostov%2C+Yordan%3BRasooly%2C+Avraham&rft.aulast=Yang&rft.aufirst=Minghui&rft.date=2010-08-15&rft.volume=25&rft.issue=12&rft.spage=2573&rft.isbn=&rft.btitle=&rft.title=Biosensors+and+Bioelectronics&rft.issn=09565663&rft_id=info:doi/10.1016%2Fj.bios.2010.04.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Milk; Food; Staphylococcal enterotoxin B; Biosensors; integrated circuits; Carbon; Electrodes; Immunoglobulin G; nanotubes; polymethylmethacrylate; Silver; polycarbonate; enterotoxin B DO - http://dx.doi.org/10.1016/j.bios.2010.04.019 ER - TY - JOUR T1 - Transgenic mice overexpressing methionine sulfoxide reductase A: Characterization of embryonic fibroblasts AN - 754538483; 13252835 AB - Methionine residues in protein can be oxidized by reactive oxygen species to generate methionine sulfoxide. Aerobic organisms have methionine sulfoxide reductases capable of reducing methionine sulfoxide back to methionine. Methionine sulfoxide reductase A acts on the S-epimer of methionine sulfoxide, and it is known that altering its cellular level by genetic ablation or overexpression has notable effects on resistance to oxidative stress and on life span in species from microorganisms to animals. In mammals, the enzyme is present in both the cytosol and the mitochondria, and this study was undertaken to assess the contribution of each subcellular compartment's reductase activity to resistance against oxidative stresses. Nontransgenic mouse embryonic fibroblasts lack methionine sulfoxide reductase A activity, providing a convenient cell type to determine the effects of expression of the enzyme in each compartment. We created transgenic mice with methionine sulfoxide reductase A targeted to the cytosol, mitochondria, or both and studied embryonic fibroblasts derived from each line. Unexpectedly, none of the transgenic cells gained resistance to a variety of oxidative stresses even though the expressed enzymes were catalytically active when assayed in vitro. Noting that activity in vivo requires thioredoxin and thioredoxin reductase, we determined the levels of these proteins in the fibroblasts and found that they were very low in both the nontransgenic and the transgenic cells. We conclude that overexpression of methionine sulfoxide reductase A did not confer resistance to oxidative stress because the cells lacked other proteins required to constitute a functional methionine sulfoxide reduction system. JF - Free Radical Biology and Medicine AU - Zhao, Hang AU - Kim, Geumsoo AU - Liu, Chengyu AU - Levine, Rodney L AD - Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA, rlevine@nih.gov Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 641 EP - 648 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 49 IS - 4 SN - 0891-5849, 0891-5849 KW - Biotechnology and Bioengineering Abstracts KW - Methionine sulfoxide reductase A KW - Mouse embryonic fibroblast KW - Oxidative stress KW - Reactive oxygen species KW - Thioredoxin KW - Thioredoxin reductase KW - Free radicals KW - Enzymes KW - Mitochondria KW - Thioredoxin-disulfide reductase KW - Transgenic mice KW - Methionine KW - reductase KW - Embryo fibroblasts KW - Cytosol KW - Microorganisms KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754538483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+Radical+Biology+and+Medicine&rft.atitle=Transgenic+mice+overexpressing+methionine+sulfoxide+reductase+A%3A+Characterization+of+embryonic+fibroblasts&rft.au=Zhao%2C+Hang%3BKim%2C+Geumsoo%3BLiu%2C+Chengyu%3BLevine%2C+Rodney+L&rft.aulast=Zhao&rft.aufirst=Hang&rft.date=2010-08-15&rft.volume=49&rft.issue=4&rft.spage=641&rft.isbn=&rft.btitle=&rft.title=Free+Radical+Biology+and+Medicine&rft.issn=08915849&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2010.05.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Thioredoxin; reductase; Reactive oxygen species; Oxidative stress; Embryo fibroblasts; Microorganisms; Cytosol; Thioredoxin-disulfide reductase; Mitochondria; Enzymes; Transgenic mice; Methionine DO - http://dx.doi.org/10.1016/j.freeradbiomed.2010.05.017 ER - TY - JOUR T1 - Mapping sources of correlation in resting state FMRI, with artifact detection and removal AN - 753685449; 13255171 AB - Many components of resting-state (RS) FMRI show non-random structure that has little to do with neural connectivity but can covary over multiple brain structures. Some of these signals originate in physiology and others are hardware-related. One artifact discussed herein may be caused by defects in the receive coil array or the RF amplifiers powering it. During a scan, this artifact results in small image intensity shifts in parts of the brain imaged by the affected array components. These shifts introduce artifactual correlations in RS time series on the spatial scale of the coil's sensitivity profile, and can markedly bias RS connectivity results. We show that such a transient artifact can be substantially removed from RS time series by using locally formed regressors from white matter tissue. This is particularly important in arrays with larger numbers of coils, which may generate smaller artifact zones. In such a case, brain-wide average noise estimates would fail to capture the artifact. We also examine the anatomical structure of artifactual variance in RS FMRI time series, by identifying sources that contribute to these signals and where in the brain are they manifested. We consider current methods for reducing confounding sources (or noises) and their effects on connectivity maps, and offer an improved approach (ANATICOR) that can also reduce hardware artifacts. The methods described herein are currently available with AFNI, in addition to tools for rapid, interactive generation of seed-based correlation maps at single-subject and group levels. JF - NeuroImage AU - Jo, Hang Joon AU - Saad, Ziad S AU - Simmons, WKyle AU - Milbury, Lydia A AU - Cox, Robert W AD - Scientific and Statistical Computing Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA, saadz@mail.nih.gov Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 571 EP - 582 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 52 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Resting state KW - Functional magnetic resonance imaging KW - Noise reduction KW - Artifact correction KW - Human brain KW - Brain mapping KW - Neuroimaging KW - Neural networks KW - Substantia alba KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753685449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Mapping+sources+of+correlation+in+resting+state+FMRI%2C+with+artifact+detection+and+removal&rft.au=Jo%2C+Hang+Joon%3BSaad%2C+Ziad+S%3BSimmons%2C+WKyle%3BMilbury%2C+Lydia+A%3BCox%2C+Robert+W&rft.aulast=Jo&rft.aufirst=Hang&rft.date=2010-08-15&rft.volume=52&rft.issue=2&rft.spage=571&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.04.246 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Brain mapping; Neuroimaging; Neural networks; Functional magnetic resonance imaging; Substantia alba DO - http://dx.doi.org/10.1016/j.neuroimage.2010.04.246 ER - TY - JOUR T1 - Occupational trichloroethylene exposure and renal carcinoma risk: evidence of genetic susceptibility by reductive metabolism gene variants. AN - 748973826; 20663906 AB - Trichloroethylene (TCE) is a suspected renal carcinogen. TCE-associated renal genotoxicity occurs predominantly through glutathione S-transferase (GST) conjugation and bioactivation by renal cysteine beta-lyase (CCBL1). We conducted a case-control study in Central Europe (1,097 cases and 1,476 controls) specifically designed to assess risk associated with occupational exposure to TCE through analysis of detailed job histories. All jobs were coded for organic/chlorinated solvent and TCE exposure (ever/never) as well as the frequency and intensity of exposure based on detailed occupational questionnaires, specialized questionnaires, and expert assessments. Increased risk was observed among subjects ever TCE exposed [odds ratio (OR) = 1.63; 95% confidence interval (95% CI), 1.04-2.54]. Exposure-response trends were observed among subjects above and below the median exposure [average intensity (OR = 1.38; 95% CI, 0.81-2.35; OR = 2.34; 95% CI, 1.05-5.21; P(trend) = 0.02)]. A significant association was found among TCE-exposed subjects with at least one intact GSTT1 allele (active genotype; OR = 1.88; 95% CI, 1.06-3.33) but not among subjects with two deleted alleles (null genotype; OR = 0.93; 95% CI, 0.35-2.44; P(interaction) = 0.18). Similar associations for all exposure metrics including average intensity were observed among GSTT1-active subjects (OR = 1.56; 95% CI, 0.79-3.10; OR = 2.77; 95% CI, 1.01-7.58; P(trend) = 0.02) but not among GSTT1 nulls (OR = 0.81; 95% CI, 0.24-2.72; OR = 1.16; 95% CI, 0.27-5.04; P(trend) = 1.00; P(interaction) = 0.34). Further evidence of heterogeneity was seen among TCE-exposed subjects with >or=1 minor allele of several CCBL1-tagging single nucleotide polymorphisms: rs2293968, rs2280841, rs2259043, and rs941960. These findings provide the strongest evidence to date that TCE exposure is associated with increased renal cancer risk, particularly among individuals carrying polymorphisms in genes that are important in the reductive metabolism of this chemical, and provides biological plausibility of the association in humans. (c)2010 AACR. JF - Cancer research AU - Moore, Lee E AU - Boffetta, Paolo AU - Karami, Sara AU - Brennan, Paul AU - Stewart, Patricia S AU - Hung, Rayjean AU - Zaridze, David AU - Matveev, Vsevolod AU - Janout, Vladimir AU - Kollarova, Helena AU - Bencko, Vladimir AU - Navratilova, Marie AU - Szeszenia-Dabrowska, Neonila AU - Mates, Dana AU - Gromiec, Jan AU - Holcatova, Ivana AU - Merino, Maria AU - Chanock, Stephen AU - Chow, Wong-Ho AU - Rothman, Nathaniel AD - Division of Cancer Epidemiology and Genetics, NIH, National Cancer Institute, NIH, Bethesda, Maryland 20852, USA. moorele@mail.nih.gov Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 6527 EP - 6536 VL - 70 IS - 16 KW - Trichloroethylene KW - 290YE8AR51 KW - glutathione S-transferase T1 KW - EC 2.5.1.- KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Carbon-Sulfur Lyases KW - EC 4.4.- KW - S-alkylcysteine lyase KW - EC 4.4.1.6 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Carbon-Sulfur Lyases -- metabolism KW - Carbon-Sulfur Lyases -- genetics KW - Humans KW - Glutathione Transferase -- metabolism KW - Case-Control Studies KW - Glutathione Transferase -- genetics KW - Genetic Predisposition to Disease KW - Male KW - Female KW - Kidney Neoplasms -- genetics KW - Trichloroethylene -- poisoning KW - Cocarcinogenesis KW - Kidney Neoplasms -- enzymology KW - Kidney Neoplasms -- chemically induced KW - Occupational Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748973826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Occupational+trichloroethylene+exposure+and+renal+carcinoma+risk%3A+evidence+of+genetic+susceptibility+by+reductive+metabolism+gene+variants.&rft.au=Moore%2C+Lee+E%3BBoffetta%2C+Paolo%3BKarami%2C+Sara%3BBrennan%2C+Paul%3BStewart%2C+Patricia+S%3BHung%2C+Rayjean%3BZaridze%2C+David%3BMatveev%2C+Vsevolod%3BJanout%2C+Vladimir%3BKollarova%2C+Helena%3BBencko%2C+Vladimir%3BNavratilova%2C+Marie%3BSzeszenia-Dabrowska%2C+Neonila%3BMates%2C+Dana%3BGromiec%2C+Jan%3BHolcatova%2C+Ivana%3BMerino%2C+Maria%3BChanock%2C+Stephen%3BChow%2C+Wong-Ho%3BRothman%2C+Nathaniel&rft.aulast=Moore&rft.aufirst=Lee&rft.date=2010-08-15&rft.volume=70&rft.issue=16&rft.spage=6527&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-09-4167 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-10 N1 - Date created - 2010-08-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 2000 May;108 Suppl 2:359-63 [10807565] Occup Environ Med. 2011 Oct;68(10):723-8 [21217163] Am J Ind Med. 2003 Mar;43(3):274-85 [12594774] Epidemiology. 2003 Sep;14(5):585-92 [14501274] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] Cancer Detect Prev. 1988;13(3-4):263-79 [3266567] CMAJ. 1989 Jun 1;140(11):1309-18 [2720514] Br J Ind Med. 1989 Sep;46(9):643-50 [2789968] Toxicol Lett. 1990 Sep;53(1-2):53-8 [2219187] Toxicol Appl Pharmacol. 1990 Oct;106(1):1-19 [2251674] Scand J Work Environ Health. 1991 Aug;17(4):231-9 [1925434] Xenobiotica. 1992 Sep-Oct;22(9-10):1135-45 [1441604] Environ Health Perspect. 1993 Dec;101 Suppl 6:53-62 [8020449] Int Arch Occup Environ Health. 1994;66(1):49-54 [7927843] Int J Epidemiol. 1995 Feb;24(1):51-7 [7797356] IARC Monogr Eval Carcinog Risks Hum. 1995;63:33-477 [9139128] Chem Biol Interact. 1997 Jul 11;105(2):99-117 [9251723] Arch Toxicol. 1997;71(9):596-9 [9285043] Arch Toxicol Suppl. 1998;20:471-4 [9442318] Chem Res Toxicol. 1998 May;11(5):464-70 [9585477] J Cancer Res Clin Oncol. 1998;124(7):374-82 [9719500] Biochem Pharmacol. 1998 Nov 1;56(9):1189-93 [9802330] Environ Health Perspect. 2000 May;108 Suppl 2:161-76 [10807550] Environ Health Perspect. 1999 May;107 Suppl 2:279-82 [10350511] Am J Ind Med. 1999 Jul;36(1):54-9 [10361587] Occup Environ Med. 1999 Mar;56(3):145-51 [10448321] Int J Cancer. 2005 Mar 10;114(1):101-8 [15523697] Annu Rev Pharmacol Toxicol. 2005;45:51-88 [15822171] J Toxicol Environ Health A. 2006 Jul;69(13):1285-309 [16754541] Ann Occup Hyg. 2006 Nov;50(8):777-87 [16840435] J Occup Environ Hyg. 2007 May;4(5):375-90 [17454505] Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1287-90 [17548699] Carcinogenesis. 2007 Sep;28(9):1960-4 [17617661] Int Arch Occup Environ Health. 2007 Nov;81(2):247-51 [17479278] Environ Mol Mutagen. 2008 Mar;49(2):142-54 [17973308] Br J Cancer. 2008 Dec 2;99(11):1912-5 [19034282] Cancer Res. 2009 Oct 15;69(20):8001-8 [19808960] Mutat Res. 2000 Oct;463(3):247-83 [11018744] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-09-4167 ER - TY - JOUR T1 - Inhibition of adipogenesis by Tempol in 3T3-L1 cells. AN - 733594924; 20561604 AB - Obesity is highly associated with an increased risk of serious health conditions including hypertension, cardiovascular disease, diabetes, and cancer. Changes in redox status with increased oxidative stress have been linked with obesity. Previous studies have shown that administration of the antioxidant Tempol in the food of mice prevents obesity, causing significant weight loss without toxicity. To gain a better understanding of the molecular mechanism(s) underlying this effect, the influence of Tempol on the differentiation of mouse 3T3-L1 preadipocytes was studied. Tempol inhibited differentiation of 3T3-L1 cells, resulting in a reduction in cellular lipid storage, down-regulation of protein levels of key adipogenesis transcription factors (PPARgamma and PPARalpha), down-regulation of prolyl hydroxylase, and up-regulation of HIF-1alpha. Mice on a Tempol diet demonstrated reduced systemic levels of IGF-1, in qualitative agreement with in vitro observations in 3T3-L1 cells, which also showed lower IGF-1 levels as a result of Tempol treatment. These results show that treatment of 3T3-L1 cells with Tempol inhibits the expression of key adipogenesis factors, adipose differentiation, and lipid storage and may underlie, at least in part, some of the in vivo effects of Tempol on body weight. Published by Elsevier Inc. JF - Free radical biology & medicine AU - Samuni, Yuval AU - Cook, John A AU - Choudhuri, Rajani AU - Degraff, William AU - Sowers, Anastasia L AU - Krishna, Murali C AU - Mitchell, James B AD - Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 667 EP - 673 VL - 49 IS - 4 KW - Antioxidants KW - 0 KW - Cyclic N-Oxides KW - Spin Labels KW - tempol KW - U78ZX2F65X KW - Index Medicus KW - Microscopy, Fluorescence KW - Weight Gain -- drug effects KW - Animals KW - Cells, Cultured KW - Mice, Inbred C3H KW - Mice KW - 3T3-L1 Cells KW - Cell Differentiation -- drug effects KW - Female KW - Antioxidants -- pharmacology KW - Cyclic N-Oxides -- pharmacology KW - Adipogenesis -- drug effects KW - Adipocytes -- drug effects KW - Adipocytes -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733594924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Inhibition+of+adipogenesis+by+Tempol+in+3T3-L1+cells.&rft.au=Samuni%2C+Yuval%3BCook%2C+John+A%3BChoudhuri%2C+Rajani%3BDegraff%2C+William%3BSowers%2C+Anastasia+L%3BKrishna%2C+Murali+C%3BMitchell%2C+James+B&rft.aulast=Samuni&rft.aufirst=Yuval&rft.date=2010-08-15&rft.volume=49&rft.issue=4&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=1873-4596&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2010.05.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-21 N1 - Date created - 2010-07-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Obes Relat Metab Disord. 1996 Dec;20(12):1073-80 [8968852] Diabetes. 2009 Jan;58(1):95-103 [18984735] Diabetes. 1998 Oct;47(10):1562-9 [9753293] Semin Cell Dev Biol. 1999 Feb;10(1):3-10 [10355023] J Biol Chem. 1999 Jun 11;274(24):17088-97 [10358062] J Clin Invest. 2004 Dec;114(12):1752-61 [15599400] Biochem Biophys Res Commun. 2005 Aug 12;333(4):1178-84 [15975549] Biochem Biophys Res Commun. 2006 Jan 13;339(2):624-32 [16310164] Exp Mol Med. 2006 Apr 30;38(2):162-72 [16672770] Biochem Pharmacol. 2006 Jun 28;72(1):42-52 [16696951] Cell Metab. 2006 Oct;4(4):263-73 [17011499] J Biol Chem. 2006 Oct 13;281(41):30678-83 [16926163] Nat Rev Mol Cell Biol. 2006 Dec;7(12):885-96 [17139329] J Cell Biochem. 2007 Aug 15;101(6):1545-57 [17370314] J Agric Food Chem. 2009 Jan 14;57(1):305-10 [19093868] Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E654-63 [19141684] Mol Cell. 1999 Oct;4(4):585-95 [10549290] Mol Cell. 1999 Oct;4(4):611-7 [10549292] J Biol Chem. 2000 Nov 3;275(44):34344-52 [10926934] J Nutr. 2000 Dec;130(12):2910-4 [11110845] J Biol Chem. 2001 Apr 13;276(15):11988-95 [11278974] J Nutr. 2001 Nov;131(11 Suppl):3109S-20S [11694656] N Engl J Med. 2002 Feb 21;346(8):591-602 [11856799] Dev Cell. 2002 Mar;2(3):331-41 [11879638] Endocrinology. 2002 Jun;143(6):2106-18 [12021175] Free Radic Biol Med. 2003 Jan 1;34(1):93-102 [12498984] Clin Endocrinol Metab. 1976 Jul;5(2):299-311 [1085232] J Clin Endocrinol Metab. 1980 Oct;51(4):781-8 [6998997] Proc Natl Acad Sci U S A. 1987 Nov;84(22):8115-9 [3317401] J Biol Chem. 1988 Dec 5;263(34):17921-4 [2848018] Bioessays. 1989 Apr;10(4):125-7 [2730632] Biochemistry. 1990 Mar 20;29(11):2802-7 [2161256] Physiol Rev. 1990 Jul;70(3):591-614 [1694588] J Biol Chem. 1991 Jun 15;266(17):11341-6 [2040638] Annu Rev Biochem. 1995;64:345-73 [7574486] Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11086-90 [7479942] J Biol Chem. 1996 Oct 18;271(42):26026-31 [8824242] Ann Nutr Metab. 2007;51(3):232-43 [17587795] Cell. 2007 Oct 19;131(2):242-56 [17956727] Cancer Res. 2008 Apr 15;68(8):2781-8 [18413745] Nutr Cancer. 2008;60(1):61-8 [18444137] Nature. 2008 Jun 5;453(7196):783-7 [18454136] J Biol Chem. 2008 Jul 25;283(30):21220-9 [18445590] Mol Cell Endocrinol. 2009 Jan 27;298(1-2):42-7 [19010385] Am J Physiol. 1997 May;272(5 Pt 1):E935-40 [9176196] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2010.05.028 ER - TY - JOUR T1 - Cognitive testing of physical activity and acculturation questions in recent and long-term Latino immigrants AN - 877603043; 13710094 AB - We ascertained the degree to which language (English versus Spanish), and residence time in the US influence responses to survey questions concerning two topics: self-reported acculturation status, and recent physical activity (PA). This topic is likely to be of general interest because of growing numbers of immigrants in countries worldwide. We carried out qualitative (cognitive) interviews of survey items on acculturation and physical activity on 27 Latino subjects from three groups: (a) In Spanish, of those of low residence time (less than five years living in the U.S.) (n = 9); (b) In Spanish, of those of high residence time (15 or more years in the U.S) (n = 9); and (c) in English, of those of high residence time (n = 9). There were very few language translation problems; general question design defects and socio-cultural challenges to survey responses were more common. Problems were found for both acculturation and PA questions, with distinct problem types for the two question areas. Residence time/language group was weakly associated with overall frequency of problems observed: low residence time/Spanish (86%), high residence time/Spanish (67%), and English speaking groups (62%). Standardized survey questions related to acculturation and physical activity present somewhat different cognitive challenges. For PA related questions, problems with such questions were similar regardless of subject residence time or language preference. For acculturation related questions, residence time/language or education level influenced responses to such questions. These observations should help in the interpretation of survey results for culturally diverse populations. JF - BMC Public Health AU - Berrigan, David AU - Forsyth, Barbara H AU - Helba, Cynthia AU - Levin, Kerry AU - Norberg, Alicia AU - Willis, Gordon B AD - Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Executive Plaza North MSC 7344, Bethesda MD 20892-7344, USA Y1 - 2010/08/13/ PY - 2010 DA - 2010 Aug 13 SP - 481 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 10 KW - Physical Education Index; CSA Neurosciences Abstracts KW - Translation KW - Physical activity KW - Immigrants KW - Communication KW - Surveys KW - Observation KW - Exercise KW - Public health KW - Education KW - Cognitive ability KW - Language KW - Interviews KW - N3 11001:Behavioral and Cognitive Neuroscience KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877603043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Public+Health&rft.atitle=Cognitive+testing+of+physical+activity+and+acculturation+questions+in+recent+and+long-term+Latino+immigrants&rft.au=Berrigan%2C+David%3BForsyth%2C+Barbara+H%3BHelba%2C+Cynthia%3BLevin%2C+Kerry%3BNorberg%2C+Alicia%3BWillis%2C+Gordon+B&rft.aulast=Berrigan&rft.aufirst=David&rft.date=2010-08-13&rft.volume=10&rft.issue=&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=BMC+Public+Health&rft.issn=1471-2458&rft_id=info:doi/10.1186%2F1471-2458-10-481 LA - English DB - Physical Education Index N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Education; Communication; Surveys; Observation; Interviews; Exercise; Public health; Translation; Cognitive ability; Physical activity; Immigrants; Language DO - http://dx.doi.org/10.1186/1471-2458-10-481 ER - TY - JOUR T1 - Structural basis for capping protein sequestration by myotrophin (V-1). AN - 748951753; 20538588 AB - Capping protein (CP) is a ubiquitously expressed, heterodimeric 62-kDa protein that binds the barbed end of the actin filament with high affinity to block further filament elongation. Myotrophin (V-1) is a 13-kDa ankyrin repeat-containing protein that binds CP tightly, sequestering it in a totally inactive complex in vitro. Here, we elucidate the molecular interaction between CP and V-1 by NMR. Specifically, chemical shift mapping and intermolecular paramagnetic relaxation enhancement experiments reveal that the ankyrin loops of V-1, which are essential for V-1/CP interaction, bind the basic patch near the joint of the alpha tentacle of CP shown previously to drive most of the association of CP with and affinity for the barbed end. Consistently, site-directed mutagenesis of CP shows that V-1 and the strong electrostatic binding site for CP on the barbed end compete for this basic patch on CP. These results can explain how V-1 inactivates barbed end capping by CP and why V-1 is incapable of uncapping CP-capped actin filaments, the two signature biochemical activities of V-1. JF - The Journal of biological chemistry AU - Zwolak, Adam AU - Fujiwara, Ikuko AU - Hammer, John A AU - Tjandra, Nico AD - Laboratory of Molecular Biophysics, HLBI, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2010/08/13/ PY - 2010 DA - 2010 Aug 13 SP - 25767 EP - 25781 VL - 285 IS - 33 KW - Actin Capping Proteins KW - 0 KW - Intercellular Signaling Peptides and Proteins KW - myotrophin KW - Index Medicus KW - Protein Binding -- physiology KW - Animals KW - Protein Structure, Secondary KW - Chickens KW - Rabbits KW - Protein Binding -- genetics KW - Mice KW - Protein Structure, Tertiary KW - Magnetic Resonance Spectroscopy KW - Intercellular Signaling Peptides and Proteins -- genetics KW - Actin Capping Proteins -- metabolism KW - Actin Capping Proteins -- genetics KW - Intercellular Signaling Peptides and Proteins -- chemistry KW - Actin Capping Proteins -- chemistry KW - Intercellular Signaling Peptides and Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748951753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Structural+basis+for+capping+protein+sequestration+by+myotrophin+%28V-1%29.&rft.au=Zwolak%2C+Adam%3BFujiwara%2C+Ikuko%3BHammer%2C+John+A%3BTjandra%2C+Nico&rft.aulast=Zwolak&rft.aufirst=Adam&rft.date=2010-08-13&rft.volume=285&rft.issue=33&rft.spage=25767&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M110.135848 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-30 N1 - Date created - 2010-08-09 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 2KXP; PDB N1 - SuppNotes - Cited By: J Am Chem Soc. 2003 Mar 12;125(10):2902-12 [12617657] J Biol Chem. 2010 Jan 22;285(4):2707-20 [19926785] Curr Biol. 2003 Sep 2;13(17):1531-7 [12956956] J Cell Biol. 2004 Feb 16;164(4):567-80 [14769858] Cell. 2004 Aug 6;118(3):363-73 [15294161] Trends Biochem Sci. 2004 Aug;29(8):418-28 [15362226] Trends Biochem Sci. 2004 Nov;29(11):572-8 [15501675] Eur J Biochem. 1980 Apr;105(2):279-87 [6991253] J Biol Chem. 2006 Apr 14;281(15):10635-50 [16434392] Science. 2006 Apr 14;312(5771):224-8 [16614210] J Biol Chem. 2006 Jul 14;281(28):19196-203 [16707503] J Biol Chem. 2006 Oct 13;281(41):31021-30 [16895918] EMBO J. 2006 Nov 29;25(23):5626-33 [17110933] J Mol Biol. 2007 Jan 12;365(2):480-501 [17059832] Biochemistry. 2006 Dec 26;45(51):15168-78 [17176038] J Cell Biol. 2006 Dec 18;175(6):947-55 [17178911] J Biol Chem. 2007 Feb 23;282(8):5871-9 [17182619] Proc Natl Acad Sci U S A. 1990 Mar;87(5):1744-8 [2155424] Nature. 1990 Mar 22;344(6264):352-4 [2179733] J Cell Biol. 1992 Dec;119(5):1151-62 [1447293] J Mol Biol. 1993 Dec 5;234(3):826-36 [8254675] J Biomol NMR. 1994 Mar;4(2):301-6 [8019138] J Biomol NMR. 1995 Jan;5(1):67-81 [7881273] Cell. 1995 May 19;81(4):591-600 [7758113] J Biol Chem. 1995 Oct 27;270(43):25316-9 [7592689] J Biol Chem. 1996 Feb 2;271(5):2812-6 [8576259] J Mol Graph. 1996 Feb;14(1):51-5, 29-32 [8744573] Mol Biol Cell. 1996 Jan;7(1):1-15 [8741835] J Cell Biol. 1996 Oct;135(1):169-79 [8858171] Biochemistry. 1997 Apr 15;36(15):4393-8 [9109646] Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3685-90 [9108038] Protein Sci. 1997 Jun;6(6):1347-51 [9194197] Curr Opin Struct Biol. 1997 Oct;7(5):732-7 [9345634] Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12366-71 [9356455] Structure. 1998 May 15;6(5):619-26 [9634699] Nat Struct Biol. 1998 Jul;5 Suppl:513-7 [9665181] J Mol Cell Cardiol. 1999 Apr;31(4):705-19 [10329199] Trends Biochem Sci. 1999 Aug;24(8):311-6 [10431175] Nature. 1999 Oct 7;401(6753):613-6 [10524632] Biophys J. 2005 Feb;88(2):1387-402 [15556992] Mol Cell Biol. 2005 May;25(9):3519-34 [15831458] Biochem Biophys Res Commun. 2005 May 27;331(1):181-6 [15845376] Dev Cell. 2005 Aug;9(2):209-21 [16054028] J Biomol NMR. 1999 Oct;15(2):151-5 [10605088] Biochemistry. 2000 May 9;39(18):5355-65 [10820006] Annu Rev Biophys Biomol Struct. 2000;29:545-76 [10940259] J Cell Biol. 2001 Jun 25;153(7):1479-97 [11425877] J Am Chem Soc. 2002 Aug 28;124(34):10025-35 [12188667] Biophys J. 2002 Sep;83(3):1237-58 [12202352] J Magn Reson. 2003 Jan;160(1):65-73 [12565051] J Biol Chem. 2003 Feb 21;278(8):5864-70 [12488317] Cell. 2003 Feb 21;112(4):453-65 [12600310] Curr Biol. 2007 Mar 6;17(5):395-406 [17331727] Nat Protoc. 2006;1(2):749-54 [17406304] J Biol Chem. 2007 Sep 21;282(38):28014-24 [17656356] Cell. 2008 May 30;133(5):841-51 [18510928] Int Rev Cell Mol Biol. 2008;267:183-206 [18544499] Protein Expr Purif. 2009 Oct;67(2):113-9 [19427903] EMBO J. 2003 Apr 1;22(7):1529-38 [12660160] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M110.135848 ER - TY - JOUR T1 - Dynamic in vivo quadriceps lines-of-action AN - 754894681; 13526995 AB - Tissue stresses and quadriceps forces are crucial factors when considering knee joint biomechanics. However, it is difficult to obtain direct, in vivo, measurements of these quantities. The primary purpose of this study was to provide the first complete description of quadriceps geometry (force directions and moment arms) of individual quadriceps components using in vivo, 3D data collected during volitional knee extension. A secondary purpose was to determine if 3D quadriceps geometry is altered in patients with patellofemoral pain and maltracking. After obtaining informed consent, cine-phase contrast (PC) MRI sets (x,y,z velocity and anatomic images) were acquired from 25 asymptomatic knees and 15 knees with patellofemoral pain during active knee extension. Using a sagittal-oblique and two coronal-oblique imaging planes, the origins and insertions of each quadriceps line-of-action were identified and tracked throughout the motion by integrating the cine-PC velocity data. The force direction and relative moment ( RM) were calculated for each line-of-action. All quadriceps lines-of-action were oriented primarily in the superior direction. There were no significant differences in quadriceps geometry between asymptomatic and subjects with patellofemoral pain. However, patellofemoral kinematics were significantly different between the two populations. This study will improve the ability of musculoskeletal models to closely match in vivo human performance by providing accurate 3D quadriceps geometry and associated patellofemoral kinematics during dynamic knee motion. Furthermore, determination that quadriceps geometry is not altered in patellofemoral pain supports the use of generalized a knee model based on asymptomatic quadriceps architecture. JF - Journal of Biomechanics AU - Wilson, Nicole A AU - Sheehan, Frances T AD - Functional and Applied Biomechanics Section, Rehabilitation Medicine Department, National Institutes of Health, Building 10 CRC RM 1-1469, 10 Center Drive MSC 1604, Bethesda, MD 20892-1604, USA, fsheehan@cc.nih.gov Y1 - 2010/08/10/ PY - 2010 DA - 2010 Aug 10 SP - 2106 EP - 2113 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 43 IS - 11 SN - 0021-9290, 0021-9290 KW - Health & Safety Science Abstracts KW - Quadriceps muscle KW - Patellofemoral pain KW - Knee KW - Moment arms KW - Modeling KW - Force directions KW - biomechanics KW - pain KW - Velocity KW - Stress KW - Human factors KW - musculoskeletal system KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754894681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomechanics&rft.atitle=Dynamic+in+vivo+quadriceps+lines-of-action&rft.au=Wilson%2C+Nicole+A%3BSheehan%2C+Frances+T&rft.aulast=Wilson&rft.aufirst=Nicole&rft.date=2010-08-10&rft.volume=43&rft.issue=11&rft.spage=2106&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomechanics&rft.issn=00219290&rft_id=info:doi/10.1016%2Fj.jbiomech.2010.04.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - biomechanics; Stress; Velocity; pain; Human factors; musculoskeletal system DO - http://dx.doi.org/10.1016/j.jbiomech.2010.04.002 ER - TY - JOUR T1 - Hollow core of Alzheimer's Abeta42 amyloid observed by cryoEM is relevant at physiological pH. AN - 748937612; 20660780 AB - Recent cryoEM density maps of Abeta(42) fibrils obtained at low pH revealed two protofilaments winding around a hollow core raising the question if such tubular structures also exist at physiological pH. Based on the cryoEM measurements and on NMR data, we probe amyloid fibril organizations corresponding to the observed cryoEM density map. Our study demonstrates that the tubular Abeta(42) fibril models exist at both acidic and physiological pH; however, the relative populations of the polymorphic models shift with pH. At acidic pH, the hollow core model exhibits higher population than the other models; at physiological pH, although it is less populated compared to the other models, structurally, it is stable and represents 8% of the population. We observe that only models with C termini facing the external surface of the fibril retain the hollow core under acidic and physiological conditions with dimensions similar to those observed by cryoEM; on the other hand, the hydrophobic effect shrinks the tubular cavity in the alternative organization. The existence of the hollow core fibril at physiological pH emphasizes the need to examine toxic effects of minor oligomeric species with unique organizations. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Miller, Yifat AU - Ma, Buyong AU - Tsai, Chung-Jung AU - Nussinov, Ruth AD - Center for Cancer Research Nanobiology Program, National Cancer Institute, Frederick, MD 21702, USA. Y1 - 2010/08/10/ PY - 2010 DA - 2010 Aug 10 SP - 14128 EP - 14133 VL - 107 IS - 32 KW - Amyloid beta-Peptides KW - 0 KW - Index Medicus KW - Hydrophobic and Hydrophilic Interactions KW - Hydrogen-Ion Concentration KW - Humans KW - Alzheimer Disease KW - Cryoelectron Microscopy KW - Protein Conformation KW - Magnetic Resonance Spectroscopy KW - Amyloid beta-Peptides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748937612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Hollow+core+of+Alzheimer%27s+Abeta42+amyloid+observed+by+cryoEM+is+relevant+at+physiological+pH.&rft.au=Miller%2C+Yifat%3BMa%2C+Buyong%3BTsai%2C+Chung-Jung%3BNussinov%2C+Ruth&rft.aulast=Miller&rft.aufirst=Yifat&rft.date=2010-08-10&rft.volume=107&rft.issue=32&rft.spage=14128&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.1004704107 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-07 N1 - Date created - 2010-08-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Protein Sci. 2000 Jan;9(1):10-9 [10739242] Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18349-54 [19015532] J Comput Chem. 2003 Aug;24(11):1348-56 [12827676] J Histochem Cytochem. 1968 Nov;16(11):673-7 [5723775] Proc Natl Acad Sci U S A. 1986 Jan;83(2):503-7 [3455785] J Mol Biol. 1997 Oct 31;273(3):729-39 [9356260] Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17345-50 [15583128] Science. 2005 Jan 14;307(5707):262-5 [15653506] J Mol Biol. 2009 Feb 27;386(3):869-77 [19038266] Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4653-8 [19264960] Biophys J. 2009 Aug 19;97(4):1168-77 [19686665] Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14339-44 [19706519] Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17751-6 [19815514] Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19813-8 [19843697] Proc Natl Acad Sci U S A. 2010 May 25;107(21):9490-5 [20448202] Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17342-7 [16293696] J Mol Biol. 2006 Jan 20;355(3):501-23 [16321400] Biochemistry. 2006 Jan 17;45(2):498-512 [16401079] PLoS Comput Biol. 2006 Apr;2(4):e42 [16683021] J Biol Chem. 2006 Aug 25;281(34):24566-74 [16787929] J Biol Chem. 2007 Feb 16;282(7):4916-23 [17170111] Nature. 2007 Sep 13;449(7159):233-7 [17767153] J Mol Biol. 2007 Nov 9;373(5):1321-33 [17905305] Proc Natl Acad Sci U S A. 2008 May 27;105(21):7462-6 [18483195] J Biol Chem. 2008 Jun 6;283(23):15988-96 [18400757] Curr Alzheimer Res. 2008 Jun;5(3):244-50 [18537541] Chem Rev. 2010 Aug 11;110(8):4820-38 [20402519] Angew Chem Int Ed Engl. 2008;47(31):5842-5 [18528917] Biochemistry. 2001 Oct 2;40(39):11757-67 [11570876] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.1004704107 ER - TY - CPAPER T1 - Asymmetry is an emergent property of the cytokinetic furrow T2 - 2010 Gordon Research Conference on Plant And Microbial Cytoskeleton AN - 1312933647; 6026610 JF - 2010 Gordon Research Conference on Plant And Microbial Cytoskeleton AU - Liu, Jian Y1 - 2010/08/08/ PY - 2010 DA - 2010 Aug 08 KW - Asymmetry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312933647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Plant+And+Microbial+Cytoskeleton&rft.atitle=Asymmetry+is+an+emergent+property+of+the+cytokinetic+furrow&rft.au=Liu%2C+Jian&rft.aulast=Liu&rft.aufirst=Jian&rft.date=2010-08-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Plant+And+Microbial+Cytoskeleton&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=plantmicro LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages AN - 759311710; 13366209 AB - Anthrax lethal toxin (LT) is an important virulence factor for Bacillus anthracis. In mice, LT lyses macrophages from certain inbred strains in less than 2h by activating the Nlrp1b inflammasome and caspase-1, while macrophages from other strains remain resistant to the toxin's effects. We analyzed LT effects in toxin-sensitive and resistant rat macrophages to test if a similar pathway was involved in rat macrophage death. LT activates caspase-1 in rat macrophages from strains harboring LT-sensitive macrophages in a manner similar to that in toxin-sensitive murine macrophages. This activation of caspase-1 is dependent on proteasome activity, and sensitive macrophages are protected from LT's lytic effects by lactacystin. Proteasome inhibition also delayed the death of rats in response to LT, confirming our previous data implicating the rat Nlrp1 inflammasome in animal death. Quinidine, caspase-1 inhibitors, the cathepsin B inhibitor CA-074Me, and heat shock also protected rat macrophages from LT toxicity. These data support the existence of an active functioning LT-responsive Nlrp1 inflammasome in rat macrophages. The activation of the rat Nlrp1 inflammasome is required for LT-mediated rat macrophage lysis and contributes to animal death. JF - Biochemical and Biophysical Research Communications AU - Newman, Zachary L AU - Crown, Devorah AU - Leppla, Stephen H AU - Moayeri, Mahtab AD - Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Drive, Building 33, Room 1W20B, Bethesda, MD 20892, USA Y1 - 2010/08/06/ PY - 2010 DA - 2010 Aug 06 SP - 785 EP - 789 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 398 IS - 4 SN - 0006-291X, 0006-291X KW - Immunology Abstracts; Toxicology Abstracts KW - Anthrax lethal toxin KW - Macrophages KW - Bacillus anthracis KW - X 24370:Natural Toxins KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759311710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Anthrax+lethal+toxin+activates+the+inflammasome+in+sensitive+rat+macrophages&rft.au=Newman%2C+Zachary+L%3BCrown%2C+Devorah%3BLeppla%2C+Stephen+H%3BMoayeri%2C+Mahtab&rft.aulast=Newman&rft.aufirst=Zachary&rft.date=2010-08-06&rft.volume=398&rft.issue=4&rft.spage=785&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2010.07.039 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2014-03-20 N1 - SubjectsTermNotLitGenreText - Macrophages; Bacillus anthracis DO - http://dx.doi.org/10.1016/j.bbrc.2010.07.039 ER - TY - JOUR T1 - Keeping the Epidermal Stem Cell Niche in Shape AN - 754895278; 13526147 AB - Recently in Nature Cell Biology, Connelly et al. (2010) identified biomechanical sensing mechanisms that link the physical shape of the stem cell microenvironment to epithelial stem cell fate decisions. Ultimately, the integration of extrinsic and intrinsic signals controls stem cell self-renewal or differentiation. JF - Cell Stem Cell AU - Iglesias-Bartolome, Ramiro AU - Gutkind, JSilvio AD - Oral and Pharyngeal Cancer Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA, sg39v@nih.gov Y1 - 2010/08/06/ PY - 2010 DA - 2010 Aug 06 SP - 143 EP - 145 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA VL - 7 IS - 2 SN - 1934-5909, 1934-5909 KW - Biotechnology and Bioengineering Abstracts KW - Integration KW - Differentiation KW - Stem cells KW - Microenvironments KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754895278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Stem+Cell&rft.atitle=Keeping+the+Epidermal+Stem+Cell+Niche+in+Shape&rft.au=Iglesias-Bartolome%2C+Ramiro%3BGutkind%2C+JSilvio&rft.aulast=Iglesias-Bartolome&rft.aufirst=Ramiro&rft.date=2010-08-06&rft.volume=7&rft.issue=2&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Cell+Stem+Cell&rft.issn=19345909&rft_id=info:doi/10.1016%2Fj.stem.2010.07.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Differentiation; Integration; Stem cells; Microenvironments DO - http://dx.doi.org/10.1016/j.stem.2010.07.008 ER - TY - JOUR T1 - Proteomic analysis of nuclei isolated from cancer cell lines treated with indenoisoquinoline NSC 724998, a novel topoisomerase I inhibitor. AN - 748934051; 20515076 AB - The indenoisoquinoline NSC724998 is a novel topoisomerase I (Top1) inhibitor entering Phase I clinical trials at the National Cancer Institute, USA. In this study, 2-D PAGE analysis was performed on nuclear lysates prepared from HCT-116 and A375 cells treated with 1 microM NSC724998 for 24 h and the differentially regulated spots identified by LC-MS/MS. One-hundred fourteen protein spot differentials were identified, 66 from A375 cells and 48 from HCT-116 cells. Proteins related to apoptosis changed specifically in A375 cells, whereas proteins involved in the ubiquitin-proteasome system were highly enriched in treated HCT-116 cells. Importantly, 12 differentially expressed proteins (ETFA, HCC1, HNRCL, KAP1, NPM, NUCL, PRDX1, PRP19, PSB6, RAE1L, RU2A, and SFRS9) were common to both cell lines. Western blotting and immunocytochemistry confirmed significant nuclear upregulation of both the proteasome subunit PSB6 and the transcriptional repressor KAP1. Interestingly, increased KAP1 polypeptide was accompanied by enhanced phosphorylation at Ser824. Similar to gammaH2AX, KAP1 phosphorylation was consistently enhanced in a panel of 12 cell lines and in A375 xenografts following NSC 724998 treatment. In summary, these data enhance our understanding of protein dynamics in the nucleus following DNA damage and provide an alternate marker (pKAP1) with potential for monitoring clinical responses to Top1 poisons. JF - Journal of proteome research AU - Han, Bingnan AU - Stockwin, Luke H AU - Hancock, Chad AU - Yu, Sherry X AU - Hollingshead, Melinda G AU - Newton, Dianne L AD - Developmental Therapeutics Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, Maryland 21702, USA. Y1 - 2010/08/06/ PY - 2010 DA - 2010 Aug 06 SP - 4016 EP - 4027 VL - 9 IS - 8 KW - Benzodioxoles KW - 0 KW - Isoquinolines KW - NSC 724998 KW - Repressor Proteins KW - TRIM28 protein, human KW - Topoisomerase I Inhibitors KW - Index Medicus KW - Mass Spectrometry KW - Blotting, Western KW - Cell Survival -- drug effects KW - DNA Damage KW - Humans KW - Repressor Proteins -- metabolism KW - Electrophoresis, Gel, Two-Dimensional KW - Chromatography, Liquid KW - Cell Line, Tumor KW - Immunohistochemistry KW - Image Processing, Computer-Assisted KW - Topoisomerase I Inhibitors -- pharmacology KW - Isoquinolines -- pharmacology KW - Cell Nucleus -- metabolism KW - Proteomics KW - Gene Expression Regulation -- drug effects KW - Cell Nucleus -- drug effects KW - Benzodioxoles -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748934051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+proteome+research&rft.atitle=Proteomic+analysis+of+nuclei+isolated+from+cancer+cell+lines+treated+with+indenoisoquinoline+NSC+724998%2C+a+novel+topoisomerase+I+inhibitor.&rft.au=Han%2C+Bingnan%3BStockwin%2C+Luke+H%3BHancock%2C+Chad%3BYu%2C+Sherry+X%3BHollingshead%2C+Melinda+G%3BNewton%2C+Dianne+L&rft.aulast=Han&rft.aufirst=Bingnan&rft.date=2010-08-06&rft.volume=9&rft.issue=8&rft.spage=4016&rft.isbn=&rft.btitle=&rft.title=Journal+of+proteome+research&rft.issn=1535-3907&rft_id=info:doi/10.1021%2Fpr100194d LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-07 N1 - Date created - 2010-08-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2002 Aug;22(16):6014-22 [12138209] Electrophoresis. 2002 Jun;23(11):1591-8 [12179976] Oncogene. 2002 Oct 17;21(47):7195-204 [12370809] Cancer Treat Rev. 2003 May;29 Suppl 1:3-9 [12738238] FASEB J. 1999 Nov;13(14):1911-22 [10544174] J Med Chem. 2000 Oct 5;43(20):3688-98 [11020283] J Biol Chem. 2000 Oct 27;275(43):33416-26 [10924506] Cancer Res. 2001 Aug 1;61(15):5926-32 [11479235] Cancer Res. 2003 Nov 1;63(21):7428-35 [14612542] Nat Cell Biol. 2003 Dec;5(12):1083-9 [14634665] Mol Cell Biol. 2004 Mar;24(5):1930-43 [14966274] J Natl Cancer Inst. 1989 Jul 19;81(14):1088-92 [2738938] Genes Dev. 1996 Aug 15;10(16):2067-78 [8769649] J Biol Chem. 1997 Sep 26;272(39):24159-64 [9305865] Mol Pharmacol. 1998 Jul;54(1):50-8 [9658189] J Med Chem. 1999 Feb 11;42(3):446-57 [9986716] J Cell Sci. 2005 Jan 1;118(Pt 1):211-22 [15615785] Mol Pharmacol. 2005 Feb;67(2):523-30 [15531731] J Cell Biochem. 2005 May 1;95(1):45-52 [15770658] J Biol Chem. 2005 Jun 24;280(25):23549-58 [15843372] Cell Mol Life Sci. 2005 Jul;62(13):1526-7 [15924260] Oncogene. 2005 Dec 1;24(54):8038-50 [16170382] J Cell Sci. 2006 May 15;119(Pt 10):1977-84 [16687735] Nat Rev Cancer. 2006 Oct;6(10):789-802 [16990856] Mol Pharm. 2006 Sep-Oct;3(5):566-78 [17009856] Biochem Biophys Res Commun. 2007 Mar 23;354(4):968-74 [17276391] Cancer Res. 2007 Apr 15;67(8):3654-62 [17440077] Clin Cancer Res. 2007 Jun 15;13(12):3667-81 [17575232] Biochem Biophys Res Commun. 2007 Sep 21;361(2):281-6 [17658460] J Proteome Res. 2007 Sep;6(9):3808-18 [17655343] Cancer Res. 2007 Nov 1;67(21):10397-405 [17974983] Cell. 2007 Nov 30;131(5):915-26 [18045534] J Biol Chem. 2007 Dec 14;282(50):36177-89 [17942393] Biochem Pharmacol. 2008 Mar 15;75(6):1262-71 [18061144] J Biol Chem. 2008 Nov 21;283(47):32669-79 [18815136] Nat Rev Cancer. 2008 Dec;8(12):957-67 [19005492] Trends Biochem Sci. 2008 Dec;33(12):592-600 [18926707] J Mol Biol. 2009 Jan 23;385(3):800-10 [19071136] Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1111-6 [19144925] Cell Mol Life Sci. 2009 Apr;66(7):1239-56 [19099192] Cell Death Differ. 2009 May;16(5):738-48 [19229245] Biochem Soc Trans. 2009 Jun;37(Pt 3):605-13 [19442257] Nat Protoc. 2009;4(6):870-7 [19444244] Cell. 2009 May 15;137(4):708-20 [19450518] J Biol Chem. 2009 May 29;284(22):14939-48 [19332537] Cancer Sci. 2009 Jul;100(7):1145-50 [19486340] Cancer Lett. 2009 Sep 28;283(1):1-9 [19201084] Int J Radiat Biol. 2009 Aug;85(8):643-55 [19579069] Cancer Res. 2009 Oct 15;69(20):7986-93 [19826036] J Cell Mol Med. 2009 Sep;13(9B):3019-31 [19522844] J Cell Mol Med. 2009 Sep;13(9B):3006-18 [19522845] Mol Cancer Ther. 2009 May;8(5):1008-14 [19383846] Erratum In: J Proteome Res. 2011 Apr 1;10(4):2128 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/pr100194d ER - TY - JOUR T1 - A single-strand specific lesion drives MMS-induced hyper-mutability at a double-strand break in yeast. AN - 748932614; 20663718 AB - Localized hyper-mutability (LHM) can be important in evolution, immunity, and genetic diseases. We previously reported that single-strand DNA (ssDNA) can be an important source of damage-induced LHM in yeast. Here, we establish that the generation of LHM by methyl methanesulfonate (MMS) during repair of a chromosomal double-strand break (DSB) can result in over 0.2 mutations/kb, which is approximately 20,000-fold higher than the MMS-induced mutation density without a DSB. The MMS-induced mutations associated with DSB repair were primarily due to substitutions via translesion DNA synthesis at damaged cytosines, even though there are nearly 10 times more MMS-induced lesions at other bases. Based on this mutation bias, the promutagenic lesion dominating LHM is likely 3-methylcytosine, which is single-strand specific. Thus, the dramatic increase in mutagenesis at a DSB is concluded to result primarily from the generation of non-repairable lesions in ssDNA associated with DSB repair along with efficient induction of highly mutagenic ssDNA-specific lesions. These findings with MMS-induced LHM have broad biological implications for unrepaired damage generated in ssDNA and possibly ssRNA. Published by Elsevier B.V. JF - DNA repair AU - Yang, Yong AU - Gordenin, Dmitry A AU - Resnick, Michael A AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States. Y1 - 2010/08/05/ PY - 2010 DA - 2010 Aug 05 SP - 914 EP - 921 VL - 9 IS - 8 KW - DNA, Single-Stranded KW - 0 KW - 3-methylcytosine KW - 4776-08-3 KW - Cytosine KW - 8J337D1HZY KW - Methyl Methanesulfonate KW - AT5C31J09G KW - DNA polymerase zeta KW - EC 2.7.7.- KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Index Medicus KW - Models, Genetic KW - Cytosine -- analogs & derivatives KW - Mutagenesis KW - DNA-Directed DNA Polymerase -- metabolism KW - Cytosine -- metabolism KW - Saccharomyces cerevisiae -- genetics KW - DNA, Single-Stranded -- metabolism KW - DNA Repair -- genetics KW - DNA, Single-Stranded -- genetics KW - Saccharomyces cerevisiae -- metabolism KW - DNA Breaks, Double-Stranded -- drug effects KW - Methyl Methanesulfonate -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748932614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=A+single-strand+specific+lesion+drives+MMS-induced+hyper-mutability+at+a+double-strand+break+in+yeast.&rft.au=Yang%2C+Yong%3BGordenin%2C+Dmitry+A%3BResnick%2C+Michael+A&rft.aulast=Yang&rft.aufirst=Yong&rft.date=2010-08-05&rft.volume=9&rft.issue=8&rft.spage=914&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=1568-7856&rft_id=info:doi/10.1016%2Fj.dnarep.2010.06.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-03 N1 - Date created - 2010-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2003 Jan 23;421(6921):436-40 [12540918] Science. 2002 Jul 26;297(5581):599-602 [12142537] Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14994-9 [14630945] Nat Rev Mol Cell Biol. 2004 Feb;5(2):148-57 [15040447] Nucleic Acids Res. 2004;32(13):3984-94 [15284331] DNA Repair (Amst). 2004 Nov 2;3(11):1389-407 [15380096] Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14051-6 [15381779] Mol Cell. 2004 Oct 8;16(1):107-16 [15469826] Biochemistry. 1979 Jun 26;18(13):2860-3 [476059] Carcinogenesis. 1984 May;5(5):691-3 [6373042] Mutat Res. 1985 Jun-Jul;150(1-2):77-84 [4000169] Nucleic Acids Res. 1985 May 10;13(9):3285-304 [2987881] Biochemistry. 1985 Oct 8;24(21):5723-8 [4084488] Mutat Res. 1990 Jul;231(1):11-30 [2195323] J Mol Biol. 1991 Apr 20;218(4):667-73 [1902520] J Mol Biol. 1992 Feb 5;223(3):617-26 [1542109] J Bacteriol. 1995 Sep;177(17):5009-15 [7665478] Genetics. 1995 Jul;140(3):965-72 [7672595] Cancer Res. 1997 Nov 1;57(21):4727-30 [9354431] Genetics. 1997 Nov;147(3):1017-24 [9383049] Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1486-91 [9990050] Genetics. 2005 Feb;169(2):575-82 [15520252] Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12849-54 [16118275] Methods Enzymol. 2006;409:329-45 [16793410] Nat Rev Immunol. 2006 Aug;6(8):573-83 [16868548] DNA Repair (Amst). 2007 Apr 1;6(4):429-42 [17112791] Proc Natl Acad Sci U S A. 2007 May 15;104(20):8403-8 [17485671] Crit Rev Biochem Mol Biol. 2007 Jul-Aug;42(4):247-58 [17687667] Genetics. 2008 Jan;178(1):67-82 [18202359] Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1170-5 [18202176] Curr Pharm Biotechnol. 2007 Dec;8(6):326-31 [18289040] Nucleic Acids Res. 2008 Apr;36(6):1836-46 [18267974] FEBS Lett. 2008 May 14;582(11):1629-33 [18435925] DNA Repair (Amst). 2008 Aug 2;7(8):1289-97 [18515192] J Am Chem Soc. 2008 Sep 3;130(35):11570-1 [18686953] J Biol Chem. 2008 Sep 5;283(36):25046-56 [18603530] PLoS One. 2008;3(11):e3714 [19005564] PLoS Genet. 2008 Nov;4(11):e1000264 [19023402] Mol Cell Biol. 2009 Mar;29(5):1212-21 [19075004] EMBO J. 2009 Feb 18;28(4):313-4 [19225445] Trends Biochem Sci. 2009 May;34(5):264-72 [19375328] PLoS Genet. 2009 Jun;5(6):e1000527 [19543366] Genomics. 2009 Jan;93(1):42-51 [18824089] Carcinogenesis. 1980 Jul;1(7):595-606 [11219835] Science. 2001 Mar 30;291(5513):2606-8 [11283373] Genes Dev. 2001 Apr 15;15(8):945-54 [11316789] Nat Biotechnol. 2001 Aug;19(8):773-6 [11479573] Nature. 2003 Feb 20;421(6925):859-63 [12594517] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.dnarep.2010.06.005 ER - TY - JOUR T1 - MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. AN - 748940844; 20624890 AB - Signaling through the adaptor protein myeloid differentiation factor 88 (MyD88) promotes carcinogenesis in several cancer models. In contrast, MyD88 signaling has a protective role in the development of azoxymethane (AOM)/dextran sodium sulfate (DSS) colitis-associated cancer (CAC). The inability of Myd88(-/-) mice to heal ulcers generated upon injury creates an altered inflammatory environment that induces early alterations in expression of genes encoding proinflammatory factors, as well as pathways regulating cell proliferation, apoptosis, and DNA repair, resulting in a dramatic increase in adenoma formation and progression to infiltrating adenocarcinomas with frequent clonal mutations in the beta-catenin gene. Others have reported that toll-like receptor (Tlr) 4-deficient mice have a similar susceptibility to colitis to Myd88-deficient mice but, unlike the latter, are resistant to CAC. We have observed that mice deficient for Tlr2 or Il1r do not show a differential susceptibility to colitis or CAC. However, upon AOM/DSS treatment Il18(-/-) and Il18r1(-/-) mice were more susceptible to colitis and polyp formation than wild-type mice, suggesting that the phenotype of Myd88(-/-) mice is, in part, a result of their inability to signal through the IL-18 receptor. This study revealed a previously unknown level of complexity surrounding MyD88 activities downstream of different receptors that impact tissue homeostasis and carcinogenesis. JF - The Journal of experimental medicine AU - Salcedo, Rosalba AU - Worschech, Andrea AU - Cardone, Marco AU - Jones, Yava AU - Gyulai, Zsofia AU - Dai, Ren-Ming AU - Wang, Ena AU - Ma, Winnie AU - Haines, Diana AU - O'hUigin, Colm AU - Marincola, Francesco M AU - Trinchieri, Giorgio AD - Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21701, USA. Y1 - 2010/08/02/ PY - 2010 DA - 2010 Aug 02 SP - 1625 EP - 1636 VL - 207 IS - 8 KW - Il18r1 protein, mouse KW - 0 KW - Interleukin-18 KW - Interleukin-18 Receptor alpha Subunit KW - Myd88 protein, mouse KW - Myeloid Differentiation Factor 88 KW - Receptors, Interleukin-1 Type I KW - STAT3 Transcription Factor KW - Stat3 protein, mouse KW - beta Catenin KW - Dextran Sulfate KW - 9042-14-2 KW - Ptgs2 protein, mouse KW - EC 1.14.99.- KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Azoxymethane KW - MO0N1J0SEN KW - Index Medicus KW - Specific Pathogen-Free Organisms KW - Gene Expression -- drug effects KW - Animals KW - Colon -- pathology KW - Colon -- drug effects KW - Azoxymethane -- pharmacology KW - Intestinal Mucosa -- metabolism KW - Inflammatory Bowel Diseases -- chemically induced KW - Mice, Knockout KW - Epithelial Cells -- metabolism KW - Apoptosis -- genetics KW - Inflammatory Bowel Diseases -- metabolism KW - Apoptosis -- drug effects KW - Receptors, Interleukin-1 Type I -- genetics KW - Intestinal Mucosa -- drug effects KW - Dextran Sulfate -- pharmacology KW - Inflammatory Bowel Diseases -- pathology KW - Cell Proliferation -- drug effects KW - Cyclooxygenase 2 -- genetics KW - Mice KW - Interleukin-18 Receptor alpha Subunit -- genetics KW - Phosphorylation -- drug effects KW - Gene Expression Profiling KW - Epithelial Cells -- drug effects KW - Gene Expression -- genetics KW - DNA Repair Enzymes -- genetics KW - Epithelial Cells -- pathology KW - Genetic Predisposition to Disease -- genetics KW - Colon -- metabolism KW - Mice, Inbred C57BL KW - Mutation -- genetics KW - Intestinal Mucosa -- pathology KW - beta Catenin -- genetics KW - STAT3 Transcription Factor -- genetics KW - Colonic Polyps -- pathology KW - Inflammatory Bowel Diseases -- genetics KW - Myeloid Differentiation Factor 88 -- metabolism KW - Signal Transduction -- physiology KW - Adenocarcinoma -- metabolism KW - Colonic Neoplasms -- genetics KW - Adenocarcinoma -- chemically induced KW - Colonic Neoplasms -- metabolism KW - Adenocarcinoma -- genetics KW - Interleukin-18 -- metabolism KW - Colonic Neoplasms -- pathology KW - Colonic Neoplasms -- chemically induced KW - Interleukin-18 -- genetics KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748940844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+experimental+medicine&rft.atitle=MyD88-mediated+signaling+prevents+development+of+adenocarcinomas+of+the+colon%3A+role+of+interleukin+18.&rft.au=Salcedo%2C+Rosalba%3BWorschech%2C+Andrea%3BCardone%2C+Marco%3BJones%2C+Yava%3BGyulai%2C+Zsofia%3BDai%2C+Ren-Ming%3BWang%2C+Ena%3BMa%2C+Winnie%3BHaines%2C+Diana%3BO%27hUigin%2C+Colm%3BMarincola%2C+Francesco+M%3BTrinchieri%2C+Giorgio&rft.aulast=Salcedo&rft.aufirst=Rosalba&rft.date=2010-08-02&rft.volume=207&rft.issue=8&rft.spage=1625&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+experimental+medicine&rft.issn=1540-9538&rft_id=info:doi/10.1084%2Fjem.20100199 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-12 N1 - Date created - 2010-08-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Genet. 2000 Mar;24(3):227-35 [10700174] PLoS One. 2009;4(6):e6026 [19551144] Cancer Res. 2002 Jul 1;62(13):3581-6 [12097256] Clin Genet. 2009 Jul;76(1):1-18 [19659756] Cancer Cell. 2009 Sep 8;16(3):208-19 [19732721] Nat Rev Cancer. 2009 Nov;9(11):798-809 [19851315] Immunity. 2010 Mar 26;32(3):379-91 [20303296] Immunity. 2010 Mar 26;32(3):367-78 [20226691] Carcinogenesis. 2003 Jan;24(1):91-7 [12538353] Scand J Gastroenterol. 2003 Aug;38(8):837-44 [12940437] Cell. 2004 Jul 23;118(2):229-41 [15260992] Cell. 2004 Aug 6;118(3):285-96 [15294155] Eur J Immunol. 2004 Sep;34(9):2347-55 [15307167] Science. 1997 Mar 21;275(5307):1790-2 [9065403] Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14863-8 [9843981] Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):99-104 [15615857] J Gastroenterol. 2005 Jan;40(1):16-23 [15692785] J Clin Invest. 2005 Mar;115(3):695-702 [15765149] Am J Physiol Gastrointest Liver Physiol. 2005 May;288(5):G1055-65 [15826931] Nat Med. 2005 Aug;11(8):845-52 [16041381] Gastroenterology. 2005 Sep;129(3):913-27 [16143131] Cancer Res. 2006 Mar 15;66(6):2953-61 [16540643] J Exp Med. 2006 Jun 12;203(6):1391-7 [16717119] Nat Rev Immunol. 2006 Nov;6(11):836-48 [17063185] J Clin Invest. 2007 Jan;117(1):258-69 [17200722] Semin Nephrol. 2007 Jan;27(1):98-114 [17336692] Nature. 2007 Mar 29;446(7135):557-61 [17361131] Immunity. 2007 Apr;26(4):461-75 [17398123] Science. 2007 Jul 6;317(5834):121-4 [17615358] Science. 2007 Jul 6;317(5834):124-7 [17615359] Cell Cycle. 2007 Oct 1;6(19):2344-7 [17700066] World J Gastroenterol. 2007 Nov 14;13(42):5560-70 [17948929] Gastroenterology. 2007 Dec;133(6):1869-81 [18054559] J Clin Invest. 2007 Dec;117(12):3909-21 [18008007] Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):652-6 [18178624] J Clin Invest. 2008 May;118(5):1727-38 [18431520] Am J Hum Genet. 2008 May;82(5):1202-10 [18439550] Curr Drug Targets. 2008 May;9(5):369-74 [18473764] Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20858-63 [19075245] Cancer Cell. 2009 Feb 3;15(2):103-13 [19185845] Mol Med. 2000 Dec;6(12):1016-27 [11474118] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1084/jem.20100199 ER - TY - JOUR T1 - Recent Findings on Peer Group Influences on Adolescent Smoking AN - 902077958; 201123552 AB - This review addresses peer group influences on adolescent smoking with a particular focus on recently published longitudinal studies that have investigated the topic. Specifically, we examine the theoretical explanations for how social influence works with respect to adolescent smoking; discuss the association between peer and adolescent smoking; consider socialization and selection processes with respect to smoking; investigate the relative influence of best friends, close friends, and crowd affiliations; and examine parenting behaviors that could buffer the effects of peer influence. Our review indicates the following with respect to adolescent smoking: (a) substantial peer group homogeneity of smoking behavior; (b) support for both socialization and selection effects, although evidence is somewhat stronger for selection; (c) an interactive influence of best friends, peer groups, and crowd affiliation; and (d) an indirect protective effect of positive parenting practices against the uptake of adolescent smoking. We conclude with implications for research and prevention programs. Adapted from the source document. JF - The Journal of Primary Prevention AU - Simons-Morton, Bruce G AU - Farhat, Tilda AD - Prevention Research Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd Room 7B13C, Bethesda, MD, 20892-7510, USA Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 191 EP - 208 PB - Springer Science+Business Media, Dordrecht, The Netherlands VL - 31 IS - 4 SN - 0278-095X, 0278-095X KW - Homogeneity KW - Friendship KW - Smoking KW - Crowds KW - Respect KW - Childrearing Practices KW - Socialization KW - Peer Groups KW - Adolescents KW - article KW - 1939: the family and socialization; adolescence & youth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902077958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Primary+Prevention&rft.atitle=Recent+Findings+on+Peer+Group+Influences+on+Adolescent+Smoking&rft.au=Simons-Morton%2C+Bruce+G%3BFarhat%2C+Tilda&rft.aulast=Simons-Morton&rft.aufirst=Bruce&rft.date=2010-08-01&rft.volume=31&rft.issue=4&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Primary+Prevention&rft.issn=0278095X&rft_id=info:doi/10.1007%2Fs10935-010-0220-x LA - English DB - Sociological Abstracts N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-28 N1 - CODEN - JPPRDT N1 - SubjectsTermNotLitGenreText - Smoking; Adolescents; Peer Groups; Friendship; Respect; Childrearing Practices; Crowds; Socialization; Homogeneity DO - http://dx.doi.org/10.1007/s10935-010-0220-x ER - TY - JOUR T1 - Total removal of unwanted harmonic peaks (TruHARP) MRI for single breath-hold high-resolution myocardial motion and strain quantification AN - 883041728; 15255592 AB - Current MRI methods for myocardial motion and strain quantification have limited resolution because of Fourier space spectral peak interference. Methods have been proposed to remove this interference in order to improve resolution; however, these methods are clinically impractical due to the prolonged imaging times. In this paper, we propose total removal of unwanted harmonic peaks (TruHARP); a myocardial motion and strain quantification methodology that uses a novel single breath-hold MR image acquisition protocol. In post-processing, TruHARP separates the spectral peaks in the acquired images, enabling high-resolution motion and strain quantification. The impact of high resolution on calculated circumferential and radial strains is studied using realistic Monte Carlo simulations, and the improvement in strain maps is demonstrated in six human subjects. Magn Reson Med, 2010. [copy 2010 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Agarwal, Harsh K AU - Prince, Jerry L AU - Abd-Elmoniem, Khaled Z AD - Departments of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland, USA, abdelmoniemkz@niddk.nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 574 EP - 585 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 64 IS - 2 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Monte Carlo simulation KW - Magnetic resonance imaging KW - N.M.R. KW - Maps KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883041728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Total+removal+of+unwanted+harmonic+peaks+%28TruHARP%29+MRI+for+single+breath-hold+high-resolution+myocardial+motion+and+strain+quantification&rft.au=Agarwal%2C+Harsh+K%3BPrince%2C+Jerry+L%3BAbd-Elmoniem%2C+Khaled+Z&rft.aulast=Agarwal&rft.aufirst=Harsh&rft.date=2010-08-01&rft.volume=64&rft.issue=2&rft.spage=574&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22403 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22403/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Monte Carlo simulation; Magnetic resonance imaging; N.M.R.; Maps DO - http://dx.doi.org/10.1002/mrm.22403 ER - TY - JOUR T1 - Designing and implementing sample and data collection for an international genetics study: the Type 1 Diabetes Genetics Consortium (T1DGC) AN - 877591148; 13419184 AB - Background and Purpose The Type 1 Diabetes Genetics Consortium (T1DGC) is an international project whose primary aims are to: (a) discover genes that modify type 1 diabetes risk; and (b) expand upon the existing genetic resources for type 1 diabetes research. The initial goal was to collect 2500 affected sibling pair (ASP) families worldwide.Methods T1DGC was organized into four regional networks (Asia-Pacific, Europe, North America, and the United Kingdom) and a Coordinating Center. A Steering Committee, with representatives from each network, the Coordinating Center, and the funding organizations, was responsible for T1DGC operations. The Coordinating Center, with regional network representatives, developed study documents and data systems. Each network established laboratories for: DNA extraction and cell line production; human leukocyte antigen genotyping; and autoantibody measurement. Samples were tracked from the point of collection, processed at network laboratories and stored for deposit at National Institute for Diabetes and Digestive and Kidney Diseases (NIDDK) Central Repositories. Phenotypic data were collected and entered into the study database maintained by the Coordinating Center.Results T1DGC achieved its original ASP recruitment goal. In response to research design changes, the T1DGC infrastructure also recruited trios, cases, and controls. Results of genetic analyses have identified many novel regions that affect susceptibility to type 1 diabetes. T1DGC created a resource of data and samples that is accessible to the research community.Limitations Participation in T1DGC was declined by some countries due to study requirements for the processing of samples at network laboratories and/or final deposition of samples in NIDDK Central Repositories. Re-contact of participants was not included in informed consent templates, preventing collection of additional samples for functional studies.Conclusions T1DGC implemented a distributed, regional network structure to reach ASP recruitment targets. The infrastructure proved robust and flexible enough to accommodate additional recruitment. T1DGC has established significant resources that provide a basis for future discovery in the study of type 1 diabetes genetics. Clinical Trials 2010; 7: S5--S32. http://ctj.sagepub.com JF - Clinical Trials AU - Hilner, Joan E AU - Perdue, Letitia H AU - Sides, Elizabeth G AU - Pierce, June J AU - Waegner, Ana M AU - Aldrich, Alan AU - Loth, Amanda AU - Albret, Lotte AU - Wagenknecht, Lynne E AU - Nierras, Concepcion AU - Akolkar, Beena AD - Division of Diabetes, Endocrinology and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA, jhilner@ms.soph.uab.edu jhilner@ms.soph.uab.edu Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - S5 EP - S32 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 7 IS - 1 SN - 1740-7745, 1740-7745 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877591148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Trials&rft.atitle=Designing+and+implementing+sample+and+data+collection+for+an+international+genetics+study%3A+the+Type+1+Diabetes+Genetics+Consortium+%28T1DGC%29&rft.au=Hilner%2C+Joan+E%3BPerdue%2C+Letitia+H%3BSides%2C+Elizabeth+G%3BPierce%2C+June+J%3BWaegner%2C+Ana+M%3BAldrich%2C+Alan%3BLoth%2C+Amanda%3BAlbret%2C+Lotte%3BWagenknecht%2C+Lynne+E%3BNierras%2C+Concepcion%3BAkolkar%2C+Beena&rft.aulast=Hilner&rft.aufirst=Joan&rft.date=2010-08-01&rft.volume=7&rft.issue=1&rft.spage=S5&rft.isbn=&rft.btitle=&rft.title=Clinical+Trials&rft.issn=17407745&rft_id=info:doi/10.1177%2F1740774510373497 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1177/1740774510373497 ER - TY - JOUR T1 - P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer [11C]-N-desmethyl-loperamide AN - 876250693; 15124098 JF - NeuroImage AU - Kreisl, William C AU - Liow, Jeih-San AU - Kimura, Nobuyo AU - Seneca, Nicholas AU - Zoghbi, Sami S AU - Morse, Cheryl L AU - Herscovitch, Peter AU - Pike, Victor W AU - Innis, Robert B AD - Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 52 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876250693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=P-glycoprotein+function+at+the+blood-brain+barrier+in+humans+can+be+quantified+with+the+substrate+radiotracer+%5B11C%5D-N-desmethyl-loperamide&rft.au=Kreisl%2C+William+C%3BLiow%2C+Jeih-San%3BKimura%2C+Nobuyo%3BSeneca%2C+Nicholas%3BZoghbi%2C+Sami+S%3BMorse%2C+Cheryl+L%3BHerscovitch%2C+Peter%3BPike%2C+Victor+W%3BInnis%2C+Robert+B&rft.aulast=Kreisl&rft.aufirst=William&rft.date=2010-08-01&rft.volume=52&rft.issue=&rft.spage=S36&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.04.218 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 DO - http://dx.doi.org/10.1016/j.neuroimage.2010.04.218 ER - TY - JOUR T1 - Chronic heavy cannabis use downregulates brain cannabinoid CB1 receptors in humans AN - 876250673; 15124079 JF - NeuroImage AU - Hirvonen, Jussi AU - Goodwin, Robert S AU - Li, Cheng-Ta AU - Morse, Cheryl AU - Zoghbi, Sami S AU - Pike, Victor W AU - Volkow, Nora D AU - Huestis, Marilyn AU - Innis, Robert B AD - National Institute of Mental Health, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 52 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876250673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Chronic+heavy+cannabis+use+downregulates+brain+cannabinoid+CB1+receptors+in+humans&rft.au=Hirvonen%2C+Jussi%3BGoodwin%2C+Robert+S%3BLi%2C+Cheng-Ta%3BMorse%2C+Cheryl%3BZoghbi%2C+Sami+S%3BPike%2C+Victor+W%3BVolkow%2C+Nora+D%3BHuestis%2C+Marilyn%3BInnis%2C+Robert+B&rft.aulast=Hirvonen&rft.aufirst=Jussi&rft.date=2010-08-01&rft.volume=52&rft.issue=&rft.spage=S14&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.04.199 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 DO - http://dx.doi.org/10.1016/j.neuroimage.2010.04.199 ER - TY - JOUR T1 - Comparison of human plasma arterial input function for [[super]11C]MePPEP determined with LC-MS/MS and radiometric methods AN - 876250624; 15124020 JF - NeuroImage AU - Pike, Victor W AU - Zoghbi, Sami S AU - Shetty, HUmesha AU - Hirvonen, Jussi AU - Anderson, Kacey B AU - Jenko, Kimberly J AU - Morse, Cheryl AU - Innis, Robert B AD - NIH/NIMH/Molecular Imaging Branch, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 52 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876250624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Comparison+of+human+plasma+arterial+input+function+for+%5B%5Bsuper%5D11C%5DMePPEP+determined+with+LC-MS%2FMS+and+radiometric+methods&rft.au=Pike%2C+Victor+W%3BZoghbi%2C+Sami+S%3BShetty%2C+HUmesha%3BHirvonen%2C+Jussi%3BAnderson%2C+Kacey+B%3BJenko%2C+Kimberly+J%3BMorse%2C+Cheryl%3BInnis%2C+Robert+B&rft.aulast=Pike&rft.aufirst=Victor&rft.date=2010-08-01&rft.volume=52&rft.issue=&rft.spage=S162&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.04.132 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 DO - http://dx.doi.org/10.1016/j.neuroimage.2010.04.132 ER - TY - JOUR T1 - Category: Methodology: Quantification and test-retest study of [super]11C-(R)-rolipram, a PET tracer of the cAMP cascade, using an arterial input function and an image-derived input function AN - 876250621; 15124019 JF - NeuroImage AU - Zanotti-Fregonara, Paolo AU - Zoghbi, Sami S AU - Liow, Jeih-San AU - Hong, Jinsoo AU - Boellaard, Ronald AU - Pike, Victor W AU - Innis, Robert B AU - Fujita, Masahiro AD - Molecular Imaging Branch, NIMH, NIH, Bethesda, Maryland, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 52 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876250621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Category%3A+Methodology%3A+Quantification+and+test-retest+study+of+%5Bsuper%5D11C-%28R%29-rolipram%2C+a+PET+tracer+of+the+cAMP+cascade%2C+using+an+arterial+input+function+and+an+image-derived+input+function&rft.au=Zanotti-Fregonara%2C+Paolo%3BZoghbi%2C+Sami+S%3BLiow%2C+Jeih-San%3BHong%2C+Jinsoo%3BBoellaard%2C+Ronald%3BPike%2C+Victor+W%3BInnis%2C+Robert+B%3BFujita%2C+Masahiro&rft.aulast=Zanotti-Fregonara&rft.aufirst=Paolo&rft.date=2010-08-01&rft.volume=52&rft.issue=&rft.spage=S161&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.04.131 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 DO - http://dx.doi.org/10.1016/j.neuroimage.2010.04.131 ER - TY - JOUR T1 - Image-derived input function for brain imaging using the high-resolution research tomograph AN - 876244911; 15124069 JF - NeuroImage AU - Zanotti-Fregonara, Paolo AU - Liow, Jeih-San AU - Fujita, Masahiro AU - Zoghbi, Sami S AU - Comtat, Claude AU - Elise, Luong AU - Boellaard, Ronald AU - Pike, Victor W AU - Innis, Robert B AD - Molecular Imaging Branch, NIMH, NIH, Bethesda, Maryland, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 52 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876244911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Image-derived+input+function+for+brain+imaging+using+the+high-resolution+research+tomograph&rft.au=Zanotti-Fregonara%2C+Paolo%3BLiow%2C+Jeih-San%3BFujita%2C+Masahiro%3BZoghbi%2C+Sami+S%3BComtat%2C+Claude%3BElise%2C+Luong%3BBoellaard%2C+Ronald%3BPike%2C+Victor+W%3BInnis%2C+Robert+B&rft.aulast=Zanotti-Fregonara&rft.aufirst=Paolo&rft.date=2010-08-01&rft.volume=52&rft.issue=&rft.spage=S222&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.04.181 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 DO - http://dx.doi.org/10.1016/j.neuroimage.2010.04.181 ER - TY - JOUR T1 - On the quantitative relationship between radiotracer lipophilicity and plasma free fraction AN - 876244907; 15124068 JF - NeuroImage AU - Zoghbi, Sami S AU - Anderson, Kacey B AU - Jenko, Kimberley J AU - Innis, Robert B AU - Pike, Victor W AD - Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 52 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876244907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=On+the+quantitative+relationship+between+radiotracer+lipophilicity+and+plasma+free+fraction&rft.au=Zoghbi%2C+Sami+S%3BAnderson%2C+Kacey+B%3BJenko%2C+Kimberley+J%3BInnis%2C+Robert+B%3BPike%2C+Victor+W&rft.aulast=Zoghbi&rft.aufirst=Sami&rft.date=2010-08-01&rft.volume=52&rft.issue=&rft.spage=S221&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.04.180 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 DO - http://dx.doi.org/10.1016/j.neuroimage.2010.04.180 ER - TY - JOUR T1 - [11C]N-desmethyl-loperamide, a substrate that selectively images P-glycoprotein function, is trapped in lysosomes AN - 876242683; 15123945 JF - NeuroImage AU - Kannan, P AU - Brimacombe, K R AU - Zoghbi, S S AU - Liow, J-S AU - Morse, C AU - Taku, A AU - Telu, S AU - Pike, V W AU - Halldin, C AU - Gottesman, M M AU - Hall, MD AU - Innis, R B AD - National Institute of Mental Health, Bethesda, MD, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 52 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876242683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=%5B11C%5DN-desmethyl-loperamide%2C+a+substrate+that+selectively+images+P-glycoprotein+function%2C+is+trapped+in+lysosomes&rft.au=Kannan%2C+P%3BBrimacombe%2C+K+R%3BZoghbi%2C+S+S%3BLiow%2C+J-S%3BMorse%2C+C%3BTaku%2C+A%3BTelu%2C+S%3BPike%2C+V+W%3BHalldin%2C+C%3BGottesman%2C+M+M%3BHall%2C+MD%3BInnis%2C+R+B&rft.aulast=Kannan&rft.aufirst=P&rft.date=2010-08-01&rft.volume=52&rft.issue=&rft.spage=S72&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.04.057 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 DO - http://dx.doi.org/10.1016/j.neuroimage.2010.04.057 ER - TY - JOUR T1 - Changes of brain phosphodiesterase 4 in major depression AN - 876239506; 15124112 JF - NeuroImage AU - Fujita, Masahiro AU - Mallinger, Alan G AU - Zarate, Carlos A AU - Dickstein, Leah P AU - Zoghbi, Sami S AU - Pike, Victor W AU - Zhang, Yi AU - Innis, Robert B AU - Drevets, Wayne C AD - National Institute of Mental Health, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 52 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876239506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Changes+of+brain+phosphodiesterase+4+in+major+depression&rft.au=Fujita%2C+Masahiro%3BMallinger%2C+Alan+G%3BZarate%2C+Carlos+A%3BDickstein%2C+Leah+P%3BZoghbi%2C+Sami+S%3BPike%2C+Victor+W%3BZhang%2C+Yi%3BInnis%2C+Robert+B%3BDrevets%2C+Wayne+C&rft.aulast=Fujita&rft.aufirst=Masahiro&rft.date=2010-08-01&rft.volume=52&rft.issue=&rft.spage=S51&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.04.232 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 DO - http://dx.doi.org/10.1016/j.neuroimage.2010.04.232 ER - TY - JOUR T1 - Synthesis of [[super]11C]astemizole as a lead candidate radioligand for imaging brain neurofibrillary tangles AN - 876233613; 15124013 JF - NeuroImage AU - Cai, Lisheng AU - Liow, Jeih-San AU - Houlihan, Brenna AU - Morse, Cheryl AU - Innis, Robert B AU - Pike, Victor W AD - Molecular Imaging Branch, National Institute of Mental Health, NIH, MD 20892, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - S152 EP - S153 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 52 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876233613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Synthesis+of+%5B%5Bsuper%5D11C%5Dastemizole+as+a+lead+candidate+radioligand+for+imaging+brain+neurofibrillary+tangles&rft.au=Cai%2C+Lisheng%3BLiow%2C+Jeih-San%3BHoulihan%2C+Brenna%3BMorse%2C+Cheryl%3BInnis%2C+Robert+B%3BPike%2C+Victor+W&rft.aulast=Cai&rft.aufirst=Lisheng&rft.date=2010-08-01&rft.volume=52&rft.issue=&rft.spage=S152&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.04.125 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 DO - http://dx.doi.org/10.1016/j.neuroimage.2010.04.125 ER - TY - JOUR T1 - What makes a good PET radioligand for brain imaging? AN - 876232087; 15124074 JF - NeuroImage AU - Pike, Victor W AD - Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 52 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876232087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=What+makes+a+good+PET+radioligand+for+brain+imaging%3F&rft.au=Pike%2C+Victor+W&rft.aulast=Pike&rft.aufirst=Victor&rft.date=2010-08-01&rft.volume=52&rft.issue=&rft.spage=S9&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.04.189 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 DO - http://dx.doi.org/10.1016/j.neuroimage.2010.04.189 ER - TY - JOUR T1 - [[super]11C]CUMI-101, an agonist radioligand for serotonin 5-HT sub(1A receptors, also binds to brain alpha) sub(1)-adrenoceptors in rodents and monkeys AN - 876231597; 15123931 JF - NeuroImage AU - Liow, Jeih-San AU - Lu, Shuiyu AU - Zoghbi, Sami S AU - Gladding, Robert L AU - Morse, Cheryl AU - Hirvonen, Jussi AU - Parsey, Ramin V AU - Innis, Robert B AU - Pike, Victor W AD - Molecular Imaging Branch, NIMH, NIH, Bethesda, Maryland, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - S56 EP - S57 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 52 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876231597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=%5B%5Bsuper%5D11C%5DCUMI-101%2C+an+agonist+radioligand+for+serotonin+5-HT+sub%281A+receptors%2C+also+binds+to+brain+alpha%29+sub%281%29-adrenoceptors+in+rodents+and+monkeys&rft.au=Liow%2C+Jeih-San%3BLu%2C+Shuiyu%3BZoghbi%2C+Sami+S%3BGladding%2C+Robert+L%3BMorse%2C+Cheryl%3BHirvonen%2C+Jussi%3BParsey%2C+Ramin+V%3BInnis%2C+Robert+B%3BPike%2C+Victor+W&rft.aulast=Liow&rft.aufirst=Jeih-San&rft.date=2010-08-01&rft.volume=52&rft.issue=&rft.spage=S56&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.04.043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 DO - http://dx.doi.org/10.1016/j.neuroimage.2010.04.043 ER - TY - JOUR T1 - PREDICTIONS OF DISPERSION AND DEPOSITION OF FALLOUT FROM NUCLEAR TESTING USING THE NOAA-HYSPLIT METEOROLOGICAL MODEL AN - 867748869; 14690845 AB - The NOAA Hybrid Single-Particle Lagrangian Integrated Trajectory Model (HYSPLIT) was evaluated as a research tool to simulate the dispersion and deposition of radioactive fallout from nuclear tests. Model-based estimates of fallout can be valuable for use in the reconstruction of past exposures from nuclear testing, particularly where little historical fallout monitoring data are available. The ability to make reliable predictions about fallout deposition could also have significant importance for nuclear events in the future. We evaluated the accuracy of the HYSPLIT-predicted geographic patterns of deposition by comparing those predictions against known deposition patterns following specific nuclear tests with an emphasis on nuclear weapons tests conducted in the Marshall Islands. We evaluated the ability of the computer code to quantitatively predict the proportion of fallout particles of specific sizes deposited at specific locations as well as their time of transport. In our simulations of fallout from past nuclear tests, historical meteorological data were used from a reanalysis conducted jointly by the National Centers for Environmental Prediction (NCEP) and the National Center for Atmospheric Research (NCAR). We used a systematic approach in testing the HYSPLIT model by simulating the release of a range of particle sizes from a range of altitudes and evaluating the number and location of particles deposited. Our findings suggest that the quantity and quality of meteorological data are the most important factors for accurate fallout predictions and that, when satisfactory meteorological input data are used, HYSPLIT can produce relatively accurate deposition patterns and fallout arrival times. Furthermore, when no other measurement data are available, HYSPLIT can be used to indicate whether or not fallout might have occurred at a given location and provide, at minimum, crude quantitative estimates of the magnitude of the deposited activity. A variety of simulations of the deposition of fallout from atmospheric nuclear tests conducted in the Marshall Islands (mid-Pacific), at the Nevada Test Site (U.S.), and at the Semipalatinsk Nuclear Test Site (Kazakhstan) were performed. The results of the Marshall Islands simulations were used in a limited fashion to support the dose reconstruction described in companion papers within this volume. JF - Health Physics AU - Moroz, B E AU - Beck, H L AU - Bouville, A AU - Simon, S L AD - National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., Bethesda, MD 20892, USA, ssimon@mail.nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 252 EP - 269 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 99 IS - 2 SN - 0017-9078, 0017-9078 KW - ASFA 1: Biological Sciences & Living Resources; Aqualine Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Pollution Abstracts KW - Prediction KW - Historical account KW - Meteorological data KW - ISEW, Pacific, Marshall Is. KW - Nuclear weapons KW - USA, Nevada KW - Model Testing KW - Particulates KW - Fallout KW - Altitude KW - Islands KW - Meteorology KW - Modelling KW - Testing Procedures KW - Particle size KW - Computers KW - Simulation KW - Model Studies KW - Weapons KW - hybrids KW - Deposition KW - Kazakhstan KW - Nuclear energy KW - Monitoring KW - Dispersion KW - SW 5010:Network design KW - Q1 08185:Genetics and evolution KW - Q5 08502:Methods and instruments KW - AQ 00005:Underground Services and Water Use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867748869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=PREDICTIONS+OF+DISPERSION+AND+DEPOSITION+OF+FALLOUT+FROM+NUCLEAR+TESTING+USING+THE+NOAA-HYSPLIT+METEOROLOGICAL+MODEL&rft.au=Moroz%2C+B+E%3BBeck%2C+H+L%3BBouville%2C+A%3BSimon%2C+S+L&rft.aulast=Moroz&rft.aufirst=B&rft.date=2010-08-01&rft.volume=99&rft.issue=2&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0b013e3181b43697 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Particle size; Meteorological data; Simulation; Modelling; Dispersion; Historical account; Weapons; hybrids; Islands; Nuclear weapons; Nuclear energy; Meteorology; Particulates; Prediction; Testing Procedures; Fallout; Altitude; Computers; Deposition; Model Testing; Monitoring; Model Studies; ISEW, Pacific, Marshall Is.; Kazakhstan; USA, Nevada DO - http://dx.doi.org/10.1097/HP.0b013e3181b43697 ER - TY - JOUR T1 - URINARY EXCRETION OF RADIONUCLIDES FROM MARSHALLESE EXPOSED TO FALLOUT FROM THE 1954 BRAVO NUCLEAR TEST AN - 867748867; 14690843 AB - Soon after the Bravo nuclear test at Bikini Atoll in the Marshall Islands on 1 March 1954, urine samples were collected for analysis of excreted radioactivity from native residents exposed to radioactive fallout on two atolls as well as from U.S. military personnel on a third atoll. The earliest acquired samples, obtained by the Los Alamos Scientific Laboratory (LASL), were assayed for various radionuclides and provided the first known measurements of super(131)I in urine following exposure to fallout from a nuclear test. Over the course of 1954, many additional samples were collected by the LASL, as well as by the Atomic Energy Commission New York Operations Office's Health and Safety Laboratory and the Naval Radiological Defense Laboratory. Collectively, the groups sampled included Marshallese exposed on Rongelap and Ailinginae Atolls, American military weather observers temporarily resident on Rongerik Atoll, and sailors from the Japanese fishing vessel, the Lucky Dragon. While the bioassay measurement data and individual urine volumes have been crucial to various attempts to assess intakes of radioactivity and the related internal radiation doses among the Marshallese, those data have never been published in any peer-reviewed journal, but have been restricted to agency memoranda, laboratory reports, and summaries in some publications and book chapters. Reconstructions of internal doses to Marshallese in 1954 and in later years have depended on these data and, hence, they have considerable historical importance as well as importance to ongoing health risk projections for Marshallese. This paper presents much of the original data on urine volumes and radioactivity from the various assays of urine for radionuclides, and compares estimates of super(131)I intakes made in 1954, 1985, 1987, and 2008. JF - Health Physics AU - Harris, P S AU - Simon, S L AU - Ibrahim, SA AD - National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., Bethesda, MD 20892, USA, ssimon@mail.nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 217 EP - 232 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 99 IS - 2 SN - 0017-9078, 0017-9078 KW - Toxicology Abstracts; Risk Abstracts; Pollution Abstracts KW - Risk assessment KW - INW, Japan KW - ISEW, Pacific, Marshall Is. KW - USA, New Mexico, Los Alamos KW - Fallout KW - Islands KW - Radiation KW - ISEW, Pacific, Marshall Is., Bikini Atoll KW - Radioactivity KW - Military KW - Weather KW - Data processing KW - Atolls KW - ANW, USA, New York KW - Urine KW - Energy KW - Books KW - Radioisotopes KW - Excretion KW - Military personnel KW - X 24390:Radioactive Materials KW - R2 23020:Technological risks KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867748867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=URINARY+EXCRETION+OF+RADIONUCLIDES+FROM+MARSHALLESE+EXPOSED+TO+FALLOUT+FROM+THE+1954+BRAVO+NUCLEAR+TEST&rft.au=Harris%2C+P+S%3BSimon%2C+S+L%3BIbrahim%2C+SA&rft.aulast=Harris&rft.aufirst=P&rft.date=2010-08-01&rft.volume=99&rft.issue=2&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0b013e3181dc50a4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Weather; Data processing; Atolls; Fallout; Islands; Radiation; Urine; Books; Energy; Radioisotopes; Excretion; Radioactivity; Military personnel; Risk assessment; Military; INW, Japan; ANW, USA, New York; ISEW, Pacific, Marshall Is., Bikini Atoll; ISEW, Pacific, Marshall Is.; USA, New Mexico, Los Alamos DO - http://dx.doi.org/10.1097/HP.0b013e3181dc50a4 ER - TY - JOUR T1 - PROJECTED LIFETIME CANCER RISKS FROM EXPOSURE TO REGIONAL RADIOACTIVE FALLOUT IN THE MARSHALL ISLANDS AN - 867748865; 14690841 AB - Radioactive fallout from nuclear test detonations during 1946-1958 at Bikini and Enewetak Atolls in the Marshall Islands (MI) exposed populations living elsewhere in the MI archipelago. A comprehensive analysis, presented in seven companion papers, has produced estimates of tissue-specific radiation absorbed dose to MI residents at all historically inhabited atolls from internal (ingested) and external irradiation resulting from exposure to radioactive fallout, by calendar year, and by age of the population at time of exposure. The present report deals, for the first time, with the implications of these doses for cancer risk among exposed members of the MI population. Radiation doses differed by geographic location and year of birth, and radiation-related cancer risk depends upon age at exposure and age at observation for risk. Using dose-response models based on committee reports published by the National Research Council and the National Institutes of Health, we project that, during the lifetimes of members of the MI population potentially exposed to ionizing radiation from weapons test fallout deposited during the testing period (1948-1958) and from residual radioactive sources during the subsequent 12 y (1959-1970), perhaps 1.6% (with 90% uncertainty range 0.4% to 3.4%) of all cancers might be attributable to fallout-related radiation exposures. By sub-population, the projected proportion of cancers attributable to radiation from fallout from all nuclear tests conducted in the Marshall Islands is 55% (28% to 69%) among 82 persons exposed in 1954 on Rongelap and Ailinginae, 10% (2.4% to 22%) for 157 persons exposed on Utrik, and 2.2% (0.5% to 4.8%) and 0.8% (0.2% to 1.8%), respectively, for the much larger populations exposed in mid-latitude locations including Kwajalein and in southern locations including Majuro. By cancer type, point estimates of attributable risk varied, by location, between 12% and 95% for thyroid cancer, between 2% and 78% for leukemia, and between 0.8% and 55% for all cancers combined. The largest projected risks pertain to the Rongelap Island community and the lowest risks pertain to the populations resident on the southern-most atolls. While the projected cancer risks are smaller than those estimated by the National Cancer Institute in a more simplistic analysis conducted in 2004, these estimates of cancer risk are the best available as they are based on the most detailed dose reconstruction to date and comprehensively include populations at all locations and dose contributions from all nuclear tests. JF - Health Physics AU - Land, CE AU - Bouville, A AU - Apostoaei, I AU - Simon, S L AD - National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., Bethesda, MD 20892, USA, ssimon@mail.nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 201 EP - 215 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 99 IS - 2 SN - 0017-9078, 0017-9078 KW - Toxicology Abstracts; Risk Abstracts; Pollution Abstracts KW - Age KW - ISEW, Pacific, Marshall Is. KW - ISEW, Pacific, Marshall Is., Enewetak Atoll KW - Thyroid KW - Atolls KW - Cancer KW - Models KW - Fallout KW - Birth KW - Leukemia KW - Weapons KW - Islands KW - Radioactive fallout KW - Dose-response effects KW - Ionizing radiation KW - Risk factors KW - thyroid cancer KW - X 24390:Radioactive Materials KW - R2 23060:Medical and environmental health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867748865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=PROJECTED+LIFETIME+CANCER+RISKS+FROM+EXPOSURE+TO+REGIONAL+RADIOACTIVE+FALLOUT+IN+THE+MARSHALL+ISLANDS&rft.au=Land%2C+CE%3BBouville%2C+A%3BApostoaei%2C+I%3BSimon%2C+S+L&rft.aulast=Land&rft.aufirst=CE&rft.date=2010-08-01&rft.volume=99&rft.issue=2&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0b013e3181dc4e84 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Birth; Fallout; Leukemia; Age; Islands; Risk factors; Ionizing radiation; thyroid cancer; Atolls; Cancer; Models; Weapons; Radioactive fallout; Dose-response effects; Thyroid; ISEW, Pacific, Marshall Is., Enewetak Atoll; ISEW, Pacific, Marshall Is. DO - http://dx.doi.org/10.1097/HP.0b013e3181dc4e84 ER - TY - JOUR T1 - ACUTE AND CHRONIC INTAKES OF FALLOUT RADIONUCLIDES BY MARSHALLESE FROM NUCLEAR WEAPONS TESTING AT BIKINI AND ENEWETAK AND RELATED INTERNAL RADIATION DOSES AN - 867748863; 14690840 AB - Annual internal radiation doses resulting from both acute and chronic intakes of all important dose-contributing radionuclides occurring in fallout from nuclear weapons testing at Bikini and Enewetak from 1946 through 1958 have been estimated for the residents living on all atolls and separate reef islands of the Marshall Islands. Internal radiation absorbed doses to the tissues most at risk to cancer induction (red bone marrow, thyroid, stomach, and colon) have been estimated for representative persons of all population communities for all birth years from 1929 through 1968, and for all years of exposure from 1948 through 1970. The acute intake estimates rely on a model using, as its basis, historical urine bioassay data, for members of the Rongelap Island and Ailinginae communities as well as for Rongerik residents. The model also utilizes fallout times of arrival and radionuclide deposition densities estimated for all tests and all atolls. Acute intakes of 63 radionuclides were estimated for the populations of the 20 inhabited atolls and for the communities that were relocated during the testing years for reasons of safety and decontamination. The model used for chronic intake estimates is based on reported whole-body, urine, and blood counting data for residents of Utrik and Rongelap. Dose conversion coefficients relating intake to organ absorbed dose were developed using internationally accepted models but specifically tailored for intakes of particulate fallout by consideration of literature-based evidence to choose the most appropriate alimentary tract absorption fraction (f sub(1)) values. Dose estimates were much higher for the thyroid gland than for red marrow, stomach wall, or colon. The highest thyroid doses to adults were about 7,600 mGy for the people exposed on Rongelap; thyroid doses to adults were much lower, by a factor of 100 or more, for the people exposed on the populated atolls of Kwajalein and Majuro. The estimates of radionuclide intake and internal radiation dose to the Marshallese that are presented in this paper are the most complete available anywhere and were used to make projections of lifetime cancer risks to the exposed populations, which are presented in a companion paper in this volume. JF - Health Physics AU - Simon, S L AU - Bouville, A AU - Melo, D AU - Beck, H L AU - Weinstock, R M AD - National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., Bethesda, MD 20892, USA, ssimon@mail.nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 157 EP - 200 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 99 IS - 2 SN - 0017-9078, 0017-9078 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Weapons KW - Islands KW - Urine KW - ISEW, Pacific, Marshall Is. KW - Radioisotopes KW - Thyroid KW - Nuclear weapons KW - Absorption KW - Canada, British Columbia, Reef I. KW - Organs KW - Cancer KW - H 8000:Radiation Safety/Electrical Safety KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867748863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=ACUTE+AND+CHRONIC+INTAKES+OF+FALLOUT+RADIONUCLIDES+BY+MARSHALLESE+FROM+NUCLEAR+WEAPONS+TESTING+AT+BIKINI+AND+ENEWETAK+AND+RELATED+INTERNAL+RADIATION+DOSES&rft.au=Simon%2C+S+L%3BBouville%2C+A%3BMelo%2C+D%3BBeck%2C+H+L%3BWeinstock%2C+R+M&rft.aulast=Simon&rft.aufirst=S&rft.date=2010-08-01&rft.volume=99&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0b013e3181dc4e51 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2013-08-12 N1 - SubjectsTermNotLitGenreText - Weapons; Islands; Urine; Absorption; Nuclear weapons; Thyroid; Radioisotopes; Organs; Cancer; ISEW, Pacific, Marshall Is.; Canada, British Columbia, Reef I. DO - http://dx.doi.org/10.1097/HP.0b013e3181dc4e51 ER - TY - JOUR T1 - DOSES FROM EXTERNAL IRRADIATION TO MARSHALL ISLANDERS FROM BIKINI AND ENEWETAK NUCLEAR WEAPONS TESTS AN - 867748862; 14690839 AB - Annual doses from external irradiation resulting from exposure to fallout from the 65 atmospheric nuclear weapons tests conducted in the Marshall Islands at Bikini and Enewetak between 1946 and 1958 have been estimated for the first time for Marshallese living on all inhabited atolls. All tests that deposited fallout on any of the 23 inhabited atolls or separate reef islands have been considered. The methodology used to estimate the radiation doses at the inhabited atolls is based on test- and location-specific radiation survey data, deposition density estimates of super(137)Cs, and fallout times-of-arrival provided in a companion paper (Beck et al.l, combined with information on the radionuclide composition of the fallout at various times after each test. These estimates of doses from external irradiation have been combined with corresponding estimates of doses from internal irradiation, given in a companion paper (Simon et al.), to assess the cancer risks among the Marshallese population (Land et al.) resulting from exposure to radiation from the nuclear weapons tests. JF - Health Physics AU - Bouville, A AU - Beck, H L AU - Simon, S L AD - National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., Bethesda, MD 20892, USA, ssimon@mail.nih.sov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 143 EP - 156 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 99 IS - 2 SN - 0017-9078, 0017-9078 KW - Risk Abstracts KW - Weapons KW - Islands KW - Irradiation KW - ISEW, Pacific, Marshall Is. KW - Nuclear weapons KW - Radioisotopes KW - Canada, British Columbia, Reef I. KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867748862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=DOSES+FROM+EXTERNAL+IRRADIATION+TO+MARSHALL+ISLANDERS+FROM+BIKINI+AND+ENEWETAK+NUCLEAR+WEAPONS+TESTS&rft.au=Bouville%2C+A%3BBeck%2C+H+L%3BSimon%2C+S+L&rft.aulast=Bouville&rft.aufirst=A&rft.date=2010-08-01&rft.volume=99&rft.issue=2&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0b013e3181dc521d LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2013-08-12 N1 - SubjectsTermNotLitGenreText - Weapons; Islands; Irradiation; Radioisotopes; Nuclear weapons; Cancer; ISEW, Pacific, Marshall Is.; Canada, British Columbia, Reef I. DO - http://dx.doi.org/10.1097/HP.0b013e3181dc521d ER - TY - JOUR T1 - RADIATION DOSES AND CANCER RISKS IN THE MARSHALL ISLANDS ASSOCIATED WITH EXPOSURE TO RADIOACTIVE FALLOUT FROM BIKINI AND ENEWETAK NUCLEAR WEAPONS TESTS: SUMMARY AN - 867737549; 14690837 AB - Nuclear weapons testing conducted at Bikini and Enewetak Atolls during 1946-1958 resulted in exposures of the resident population of the present-day Republic of the Marshall Islands to radioactive fallout. This paper summarizes the results of a thorough and systematic reconstruction of radiation doses to that population, by year, age at exposure, and atoll of residence, and the related cancer risks. Detailed methods and results are presented in a series of companion papers in this volume. From our analysis, we concluded that 20 of the 66 nuclear tests conducted in or near the Marshall Islands resulted in measurable fallout deposition on one or more of the inhabited atolls of the Marshall Islands. In this work, we estimated deposition densities (kBq m super(-2)) of all important dose-contributing radionuclides at each of the 32 atolls and separate reef islands of the Marshall Islands. Quantitative deposition estimates were made for 63 radionuclides from each test at each atoll. Those estimates along with reported measurements of exposure rates at various times after fallout were used to estimate radiation absorbed doses to the red bone marrow, thyroid gland, stomach wall, and colon wall of atoll residents from both external and internal exposure. Annual doses were estimated for six age groups ranging from newborns to adults. We found that the total deposition of super(137)Cs, external dose, internal organ doses, and cancer risks followed the same geographic pattern with the large population of the southern atolls receiving the lowest doses. Permanent residents of the southern atolls who were of adult age at the beginning of the testing period received external doses ranging from 5 to 12 mGy on average; the external doses to adults at the mid-latitude atolls ranged from 22 to 59 mGy on average, while the residents of the northern atolls received external doses in the hundreds to over 1,000 mGy. Internal doses varied significantly by age at exposure, location, and organ. Except for internal doses to the thyroid gland, external exposure was generally the major contributor to organ doses, particularly for red bone marrow and stomach wall. Internal doses to the stomach wall and red bone marrow were similar in magnitude, about 1 mGy to 7 mGy for permanent residents of the southern and mid-latitude atolls. However, adult residents of Utrik and Rongelap Island, which are part of the northern atolls, received much higher internal doses because of intakes of short-lived radionuclides leading to doses from 20 mGy to more than 500 mGy to red bone marrow and stomach wall. In general, internal doses to the colon wall were four to ten times greater than those to the red bone marrow and internal doses to the thyroid gland were 20 to 30 times greater than to the red bone marrow. Adult internal thyroid doses for the Utrik community and for the Rongelap Island community were about 760 mGy and 7,600 mGy, respectively. The highest doses were to the thyroid glands of young children exposed on Rongelap at the time of the Castle Bravo test of 1 March 1954 and were about three times higher than for adults. Internal doses from chronic intakes, related to residual activities of long-lived radionuclides in the environment, were, in general, low in comparison with acute exposure resulting from the intakes of radionuclides immediately or soon after the deposition of fallout. The annual doses and the population sizes at each atoll in each year were used to develop estimates of cancer risks for the permanent residents of all atolls that were inhabited during the testing period as well as for the Marshallese population groups that were relocated prior to the testing or after it had begun. About 170 excess cancers (radiation-related cases) are projected to occur among more than 25,000 Marshallese, half of whom were born before 1948. All but about 65 of those cancers are estimated to have already been expressed. The 170 excess cancers are in comparison to about 10,600 cancers that would spontaneously arise, unrelated to radioactive fallout, among the same cohort of Marshallese people. JF - Health Physics AU - Simon, S L AU - Bouville, A AU - Land, CE AU - Beck, H L AD - National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., Bethesda, MD 20892, USA, ssimon@mail.nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 105 EP - 123 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 99 IS - 2 SN - 0017-9078, 0017-9078 KW - Toxicology Abstracts; Risk Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - Reefs KW - Age KW - Reconstruction KW - ISEW, Pacific, Marshall Is. KW - Bone marrow KW - Fallout KW - Islands KW - Colon KW - Radiation KW - Canada, British Columbia, Reef I. KW - ISEW, Pacific, Marshall Is., Enewetak Atoll KW - Thyroid KW - Atolls KW - Children KW - Organs KW - Cancer KW - Weapons KW - Radioactive fallout KW - Books KW - Radioisotopes KW - Neonates KW - Stomach KW - X 24390:Radioactive Materials KW - H 8000:Radiation Safety/Electrical Safety KW - R2 23060:Medical and environmental health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867737549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=RADIATION+DOSES+AND+CANCER+RISKS+IN+THE+MARSHALL+ISLANDS+ASSOCIATED+WITH+EXPOSURE+TO+RADIOACTIVE+FALLOUT+FROM+BIKINI+AND+ENEWETAK+NUCLEAR+WEAPONS+TESTS%3A+SUMMARY&rft.au=Simon%2C+S+L%3BBouville%2C+A%3BLand%2C+CE%3BBeck%2C+H+L&rft.aulast=Simon&rft.aufirst=S&rft.date=2010-08-01&rft.volume=99&rft.issue=2&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0b013e3181dc523c LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Reefs; Age; Reconstruction; Bone marrow; Thyroid; Children; Atolls; Cancer; Fallout; Islands; Radiation; Colon; Books; Radioisotopes; Neonates; Stomach; Weapons; Radioactive fallout; Organs; ISEW, Pacific, Marshall Is., Enewetak Atoll; ISEW, Pacific, Marshall Is.; Canada, British Columbia, Reef I. DO - http://dx.doi.org/10.1097/HP.0b013e3181dc523c ER - TY - JOUR T1 - A 2000-year record of copper pollution in South China Sea derived from seabird excrements; a potential indicator for copper production and civilization of China AN - 849005367; 2011-015302 AB - In the Chinese feudal era, copper was widely used in coinage and weapons, and its production was coupled with political stability and economic prosperity. In the smelting process, copper was released into the environment and accumulated in the food web, and it became enriched in animal tissues and in seabird droppings. Here we report a 2000-year record of copper in red-footed booby excrement from Dongdao Island, South China Sea. There exists a striking correlation between the copper content in the seabird excrements and the ancient copper production of China for past two millennia. The increased Cu content corresponds to the flourishing times of dynasties, such as the Tang and Sung Dynasties, and declines in Cu content correspond with dynastic declines. Even some brief (decadal) wars and calamities, such as the Anshi Rebellion in AD 755-763 and the Taiping Heavenly Kingdom in AD 1851-1864, were recorded in the copper content profile. We established an approximate function to model the quantitative relationship between the copper content in the seabird excrement and the ancient copper production. We estimate that a total of approximately 14 million tons of copper was produced during the past two millennia in China. Among the 14 million tons of copper, about 0.65 million tons was released into the atmosphere. Copyright 2010 Springer Science+Business Media B.V. JF - Journal of Paleolimnology AU - Yan, Hong AU - Sun, Liguang AU - Wang, Yuhong AU - Liu, Xiaodong AU - Qiu, Shican AU - Cheng, Wenhan Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 431 EP - 442 PB - Springer, Dordrecht VL - 44 IS - 2 SN - 0921-2728, 0921-2728 KW - Far East KW - isotopes KW - copper KW - Xisha Islands KW - Holocene KW - cores KW - West Pacific KW - guano KW - Cenozoic KW - radioactive isotopes KW - Dongdao Island KW - carbon KW - sediments KW - absolute age KW - Northwest Pacific KW - Asia KW - South China Sea KW - China KW - Quaternary KW - human activity KW - paleoenvironment KW - North Pacific KW - metals KW - Pacific Ocean KW - lacustrine environment KW - Cattle Pond KW - C-14 KW - upper Holocene KW - lake sediments KW - 24:Quaternary geology KW - 03:Geochronology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849005367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Paleolimnology&rft.atitle=A+2000-year+record+of+copper+pollution+in+South+China+Sea+derived+from+seabird+excrements%3B+a+potential+indicator+for+copper+production+and+civilization+of+China&rft.au=Yan%2C+Hong%3BSun%2C+Liguang%3BWang%2C+Yuhong%3BLiu%2C+Xiaodong%3BQiu%2C+Shican%3BCheng%2C+Wenhan&rft.aulast=Yan&rft.aufirst=Hong&rft.date=2010-08-01&rft.volume=44&rft.issue=2&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=Journal+of+Paleolimnology&rft.issn=09212728&rft_id=info:doi/10.1007%2Fs10933-010-9413-9 L2 - http://www.springerlink.com/(i42ivkufd5oczp45mspwbbyb)/app/home/journal.asp?referrer=parent&backto=linkingpublicationresults,1:100294,1 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by Springer Verlag, Berlin, Federal Republic of Germany N1 - Date revised - 2011-01-01 N1 - Number of references - 48 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - absolute age; Asia; C-14; carbon; Cattle Pond; Cenozoic; China; copper; cores; Dongdao Island; Far East; guano; Holocene; human activity; isotopes; lacustrine environment; lake sediments; metals; North Pacific; Northwest Pacific; Pacific Ocean; paleoenvironment; Quaternary; radioactive isotopes; sediments; South China Sea; upper Holocene; West Pacific; Xisha Islands DO - http://dx.doi.org/10.1007/s10933-010-9413-9 ER - TY - JOUR T1 - The chemical biology of new drugs in the development for tuberculosis AN - 807259524; 13715276 AB - With the worldwide emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb), there are serious concerns about the continued ability to contain this disease. We discuss the most promising new drugs in late-stage development that might be useful in treating MDR and XDR forms of the disease. These agents have novel mechanisms of action that are not targeted by the standard drugs used presently to treat susceptible strains. JF - Current Opinion in Chemical Biology AU - Blanchard, John S AD - Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, United States, blanchar@aecom.yu.edu Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 456 EP - 466 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 14 IS - 4 SN - 1367-5931, 1367-5931 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology KW - Drug development KW - Drug resistance KW - Mycobacterium tuberculosis KW - W 30965:Miscellaneous, Reviews KW - J:02490 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807259524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Chemical+Biology&rft.atitle=The+chemical+biology+of+new+drugs+in+the+development+for+tuberculosis&rft.au=Blanchard%2C+John+S&rft.aulast=Blanchard&rft.aufirst=John&rft.date=2010-08-01&rft.volume=14&rft.issue=4&rft.spage=456&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Chemical+Biology&rft.issn=13675931&rft_id=info:doi/10.1016%2Fj.cbpa.2010.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Drug resistance; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1016/j.cbpa.2010.04.008 ER - TY - JOUR T1 - Structure of the N-terminal fragment of Escherichia coli Lon protease AN - 787254550; 13665215 AB - The structure of a recombinant construct consisting of residues 1-245 of Escherichia coli Lon protease, the prototypical member of the A-type Lon family, is reported. This construct encompasses all or most of the N-terminal domain of the enzyme. The structure was solved by SeMet SAD to 2.6 Aa resolution utilizing trigonal crystals that contained one molecule in the asymmetric unit. The molecule consists of two compact subdomains and a very long C-terminal a-helix. The structure of the first subdomain (residues 1-117), which consists mostly of b-strands, is similar to that of the shorter fragment previously expressed and crystallized, whereas the second subdomain is almost entirely helical. The fold and spatial relationship of the two subdomains, with the exception of the C-terminal helix, closely resemble the structure of BPP1347, a 203-amino-acid protein of unknown function from Bordetella parapertussis, and more distantly several other proteins. It was not possible to refine the structure to satisfactory convergence; however, since almost all of the Se atoms could be located on the basis of their anomalous scattering the correctness of the overall structure is not in question. The structure reported here was also compared with the structures of the putative substrate-binding domains of several proteins, showing topological similarities that should help in defining the binding sites used by Lon substrates. JF - Acta Crystallographica Section D AU - Li, Mi AU - Gustchina, Alla AU - Rasulova, Fatima S AU - Melnikov, Edward E AU - Maurizi, Michael R AU - Rotanova, Tatyana V AU - Dauter, Zbigniew AU - Wlodawer, Alexander AD - aProtein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA, wlodawer@nih.gov Y1 - 2010/08/01/ PY - 2010 DA - 2010 Aug 01 SP - 865 EP - 873 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 66 IS - 8 SN - 0907-4449, 0907-4449 KW - Microbiology Abstracts B: Bacteriology KW - anomalous diffraction KW - ATP-dependent proteases KW - protein domains KW - structure quality KW - Lon protease KW - Protein folding KW - Lon protein KW - Convergence KW - Bordetella parapertussis KW - Escherichia coli KW - Enzymes KW - Crystals KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/787254550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Crystallographica+Section+D&rft.atitle=Structure+of+the+N-terminal+fragment+of+Escherichia+coli+Lon+protease&rft.au=Li%2C+Mi%3BGustchina%2C+Alla%3BRasulova%2C+Fatima+S%3BMelnikov%2C+Edward+E%3BMaurizi%2C+Michael+R%3BRotanova%2C+Tatyana+V%3BDauter%2C+Zbigniew%3BWlodawer%2C+Alexander&rft.aulast=Li&rft.aufirst=Mi&rft.date=2010-08-01&rft.volume=66&rft.issue=8&rft.spage=865&rft.isbn=&rft.btitle=&rft.title=Acta+Crystallographica+Section+D&rft.issn=09074449&rft_id=info:doi/10.1107%2FS0907444910019554 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Protein folding; Convergence; Lon protein; Enzymes; Crystals; Escherichia coli; Bordetella parapertussis DO - http://dx.doi.org/10.1107/S0907444910019554 ER - TY - JOUR T1 - From complete genome sequence to a~complete' understanding? AN - 787055300; 13247875 AB - The rapidly accumulating genome sequence data allow researchers to address fundamental biological questions that were not even asked just a few years ago. A major problem in genomics is the widening gap between the rapid progress in genome sequencing and the comparatively slow progress in the functional characterization of sequenced genomes. Here we discuss two key questions of genome biology: whether we need more genomes, and how deep is our understanding of biology based on genomic analysis. We argue that overly specific annotations of gene functions are often less useful than the more generic, but also more robust, functional assignments based on protein family classification. We also discuss problems in understanding the functions of the remaining a~conserved hypothetical' genes. JF - Trends in Biotechnology AU - Galperin, Michael Y AU - Koonin, Eugene V AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, galperin@ncbi.nlm.nih.gov PY - 2010 SP - 398 EP - 406 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 28 IS - 8 SN - 0167-7799, 0167-7799 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Data processing KW - Nucleotide sequence KW - Reviews KW - Genomic analysis KW - protein families KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/787055300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Biotechnology&rft.atitle=From+complete+genome+sequence+to+a%7Ecomplete%27+understanding%3F&rft.au=Galperin%2C+Michael+Y%3BKoonin%2C+Eugene+V&rft.aulast=Galperin&rft.aufirst=Michael&rft.date=2010-08-01&rft.volume=28&rft.issue=8&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=Trends+in+Biotechnology&rft.issn=01677799&rft_id=info:doi/10.1016%2Fj.tibtech.2010.05.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2016-01-06 N1 - SubjectsTermNotLitGenreText - Data processing; Reviews; Nucleotide sequence; Genomic analysis; protein families DO - http://dx.doi.org/10.1016/j.tibtech.2010.05.006 ER - TY - JOUR T1 - UMLS content views appropriate for NLP processing of the biomedical literature vs. clinical text AN - 787050946; 13216686 AB - Identification of medical terms in free text is a first step in such Natural Language Processing (NLP) tasks as automatic indexing of biomedical literature and extraction of patients' problem lists from the text of clinical notes. Many tools developed to perform these tasks use biomedical knowledge encoded in the Unified Medical Language System (UMLS) Metathesaurus. We continue our exploration of automatic approaches to creation of subsets (UMLS content views) which can support NLP processing of either the biomedical literature or clinical text. We found that suppression of highly ambiguous terms in the conservative AutoFilter content view can partially replace manual filtering for literature applications, and suppression of two character mappings in the same content view achieves 89.5% precision at 78.6% recall for clinical applications. JF - Journal of Biomedical Informatics AU - Demner-Fushman, Dina AU - Mork, James G AU - Shooshan, Sonya E AU - Aronson, Alan R AD - Lister Hill National Center for Biomedical Communications (LHNCBC), U.S. National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, ddemner@mail.nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 587 EP - 594 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 43 IS - 4 SN - 1532-0464, 1532-0464 KW - Biotechnology and Bioengineering Abstracts KW - UMLS KW - Metathesaurus KW - Content views KW - Natural Language Processing KW - Indexing KW - Clinical text KW - Therapeutic applications KW - Language KW - Mapping KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/787050946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Informatics&rft.atitle=UMLS+content+views+appropriate+for+NLP+processing+of+the+biomedical+literature+vs.+clinical+text&rft.au=Demner-Fushman%2C+Dina%3BMork%2C+James+G%3BShooshan%2C+Sonya+E%3BAronson%2C+Alan+R&rft.aulast=Demner-Fushman&rft.aufirst=Dina&rft.date=2010-08-01&rft.volume=43&rft.issue=4&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Informatics&rft.issn=15320464&rft_id=info:doi/10.1016%2Fj.jbi.2010.02.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Therapeutic applications; Language; Bioinformatics; Mapping DO - http://dx.doi.org/10.1016/j.jbi.2010.02.005 ER - TY - JOUR T1 - Shortest Path Refinement for Motion Estimation From Tagged MR Images AN - 759314885; 13674822 AB - Magnetic resonance tagging makes it possible to measure the motion of tissues such as muscles in the heart and tongue. The harmonic phase (HARP) method largely automates the process of tracking points within tagged MR images, permitting many motion properties to be computed. However, HARP tracking can yield erroneous motion estimates due to 1) large deformations between image frames, 2) through-plane motion, and 3) tissue boundaries. Methods that incorporate the spatial continuity of motion--so-called refinement or flood-filling methods--have previously been reported to reduce tracking errors. This paper presents a new refinement method based on shortest path computations. The method uses a graph representation of the image and seeks an optimal tracking order from a specified seed to each point in the image by solving a single source shortest path problem. This minimizes the potential errors for those path dependent solutions that are found in other refinement methods. In addition to this, tracking in the presence of through-plane motion is improved by introducing synthetic tags at the reference time (when the tissue is not deformed). Experimental results on both tongue and cardiac images show that the proposed method can track the whole tissue more robustly and is also computationally efficient. JF - IEEE Transactions on Medical Imaging AU - Liu, Xiaofeng AU - Prince, Jerry L AD - Radiology and Imaging Science, Clinical Center, Department of Computer Science, National Institutes of Health, Johns Hopkins University, Bethesda, Baltimore, Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1560 EP - 1572 PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 USA VL - 29 IS - 8 SN - 0278-0062, 0278-0062 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Seeds KW - Muscles KW - Boundaries KW - Cardiac muscle KW - Tongue KW - N.M.R. KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759314885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Medical+Imaging&rft.atitle=Shortest+Path+Refinement+for+Motion+Estimation+From+Tagged+MR+Images&rft.au=Liu%2C+Xiaofeng%3BPrince%2C+Jerry+L&rft.aulast=Liu&rft.aufirst=Xiaofeng&rft.date=2010-08-01&rft.volume=29&rft.issue=8&rft.spage=1560&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Medical+Imaging&rft.issn=02780062&rft_id=info:doi/10.1109%2FTMI.2010.2045509 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Heart; Seeds; Boundaries; Muscles; Cardiac muscle; N.M.R.; Tongue DO - http://dx.doi.org/10.1109/TMI.2010.2045509 ER - TY - JOUR T1 - Determination of levels of persistent organic pollutants (PCDD/Fs, PBDD/Fs, PBDEs, PCBs, and PBBs) in atmosphere near a municipal solid waste incinerator AN - 759312690; 13513723 AB - This work develops a comprehensive approach for quantitatively analyzing polychlorinated and polybrominated dibenzo-p-dioxins (PCDDs/PBDDs), dibenzofurans (PCDFs/PBDFs), biphenyls (PCBs/PBBs) and diphenyl ethers (PBDEs). This technique, based on multiple (silica, alumina, and active carbon) columns, can be applied to prepare samples for determining the five group compounds based on high-resolution gas chromatography/high-resolution mass spectrometry. The method was also validated by analyses of blank and spiked samples. In the sampled air, the mean PCDD/F, PCB, PBDD/F, PBDE, and PBB concentrations were 59.6fg WHO-TEQ Nm super(-3), 6.74fg WHO-TEQ Nm super(-3), 12.2fg WHO-TEQ Nm super(-3), 52100fgNm super(-3), and 341fgNm super(-3), respectively. The WHO-TEQ of dioxin-like PCB and PBDD/Fs counted for 8.9% and 16% of total TEQ (summed over PCDD/Fs, PBDD/Fs, and dioxin-like PCBs), respectively, suggesting that the atmospheric concentrations of dioxin and dioxin-like compounds should be regulated together because of the persistence and toxicity of PBDD/Fs and dioxin-like PCBs. JF - Chemosphere AU - Wang, Mao-Sung AU - Chen, Shui-Jen AU - Huang, Kuo-Lin AU - Lai, Yi-Chieh AU - Chang-Chien, Guo-Ping AU - Tsai, Jen-Hsiung AU - Lin, Wen-Yinn AU - Chang, Kuo-Ching AU - Lee, Jia-Twu AD - Department of Environmental Engineering Science, National Pingtung University of Science and Technology, 1 Shue-Fu Rd., Nei Pu 91207, Pingtung, Taiwan Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1220 EP - 1226 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 80 IS - 10 SN - 0045-6535, 0045-6535 KW - ASFA 2: Ocean Technology Policy & Non-Living Resources; Environment Abstracts; Meteorological & Geoastrophysical Abstracts; Pollution Abstracts; Toxicology Abstracts KW - Atmosphere KW - Brominated flame retardants KW - Column chromatography KW - Persistent organic pollutants KW - Municipal solid waste incinerators KW - Chromatographic techniques KW - diphenyl ether KW - Mass spectrometry KW - Dioxins KW - Municipal solid wastes KW - Solid wastes KW - Mass spectroscopy KW - Carbon KW - Pollutants KW - Gas chromatography KW - silica KW - Pollutant persistence KW - Ethers KW - PCB compounds KW - PCDD KW - PCB KW - PBDE KW - Atmospheric gases KW - Atmospheric pollution KW - Toxicity KW - Chlorinated hydrocarbons KW - Biphenyl KW - polybrominated diphenyl ethers KW - Incineration KW - Silica KW - polychlorinated biphenyls KW - Dibenzofuran KW - Aluminum KW - Dibenzo-p-dioxin KW - Incinerators KW - Dioxin KW - M2 551.510.42:Air Pollution (551.510.42) KW - Q2 09405:Oil and gas KW - P 0000:AIR POLLUTION KW - X 24360:Metals KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759312690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Determination+of+levels+of+persistent+organic+pollutants+%28PCDD%2FFs%2C+PBDD%2FFs%2C+PBDEs%2C+PCBs%2C+and+PBBs%29+in+atmosphere+near+a+municipal+solid+waste+incinerator&rft.au=Wang%2C+Mao-Sung%3BChen%2C+Shui-Jen%3BHuang%2C+Kuo-Lin%3BLai%2C+Yi-Chieh%3BChang-Chien%2C+Guo-Ping%3BTsai%2C+Jen-Hsiung%3BLin%2C+Wen-Yinn%3BChang%2C+Kuo-Ching%3BLee%2C+Jia-Twu&rft.aulast=Wang&rft.aufirst=Mao-Sung&rft.date=2010-08-01&rft.volume=80&rft.issue=10&rft.spage=1220&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/10.1016%2Fj.chemosphere.2010.06.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - PBDE; Incineration; Atmospheric gases; Pollutants; Chromatographic techniques; Pollutant persistence; Toxicity; Chlorinated hydrocarbons; PCB; diphenyl ether; Atmosphere; Mass spectroscopy; Solid wastes; Biphenyl; polychlorinated biphenyls; Carbon; Silica; Gas chromatography; Dibenzofuran; Aluminum; Dibenzo-p-dioxin; Incinerators; Dioxin; Atmospheric pollution; Mass spectrometry; polybrominated diphenyl ethers; silica; Ethers; PCB compounds; Municipal solid wastes; PCDD; Dioxins DO - http://dx.doi.org/10.1016/j.chemosphere.2010.06.007 ER - TY - JOUR T1 - Prenatal exposure to the major DDT metabolite 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and growth in boys from Mexico AN - 759309889; 13248086 AB - Recent data suggest that prenatal exposure to p,pa super(2)-DDE may reduce height and increase body mass index (BMI) in childhood, thus potentially raising the risk of adult health problems. The association between prenatal DDE exposure and growth was evaluated in 788 boys from Chiapas, an area of Mexico where DDT was recently used. The median DDE levels in maternal serum at birth (2002-2003) were 2.7I14g/g lipid. 2633 measurements of height (cm) and weight (kg) were obtained in 2004-2005. The median age of the children during follow-up was 18 months (quartiles 14 and 22 months). Height and body mass index (kg/m2) were age-standardized and expressed as standard deviation scores (SDS). Multivariate random-effect models for longitudinal data were fitted and predicted height and BMI SDS were estimated from the adjusted models. Overall, associations between prenatal DDE level and height or BMI SDS at any given age were not observed. For example, the predicted values showed that children with the highest exposure (DDE: >9.00I14g/g) compared to those least exposed (DDE: <3.01I14g/g) grew similarly and they had a BMI SDS similar to the referent group. The results do not support the prior findings of an association of DDE exposure with childhood height or BMI. JF - Environmental Research AU - Cupul-Uicab, Lea A AU - Hernandez-Avila, Mauricio AU - Terrazas-Medina, Efrain A AU - Pennell, Michael L AU - Longnecker, Matthew P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, MD A3-05, 111 TW Alexander Dr, Research Triangle Park, NC 27709, USA PY - 2010 SP - 595 EP - 603 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 110 IS - 6 SN - 0013-9351, 0013-9351 KW - Risk Abstracts; Health & Safety Science Abstracts; Environment Abstracts; Toxicology Abstracts; Sustainability Science Abstracts KW - Body height KW - Body mass index KW - Child KW - Preschool KW - Growth and development KW - Infant KW - Longitudinal study KW - ppa super(2)-DDE KW - BMI KW - DDE KW - DDT KW - IQR KW - SD KW - SDS KW - Age KW - Prenatal experience KW - Lipids KW - Bone growth KW - Metabolites KW - Models KW - Insecticides KW - Nitrous oxide KW - body mass KW - Data processing KW - Children KW - Birth KW - prenatal experience KW - Mexico KW - Standard deviation KW - Sodium lauryl sulfate KW - Mexico, Chiapas KW - M3 1010:Issues in Sustainable Development KW - R2 23050:Environment KW - H 0500:General KW - X 24330:Agrochemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759309889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=Prenatal+exposure+to+the+major+DDT+metabolite+1%2C1-dichloro-2%2C2-bis%28p-chlorophenyl%29ethylene+%28DDE%29+and+growth+in+boys+from+Mexico&rft.au=Cupul-Uicab%2C+Lea+A%3BHernandez-Avila%2C+Mauricio%3BTerrazas-Medina%2C+Efrain+A%3BPennell%2C+Michael+L%3BLongnecker%2C+Matthew+P&rft.aulast=Cupul-Uicab&rft.aufirst=Lea&rft.date=2010-08-01&rft.volume=110&rft.issue=6&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/10.1016%2Fj.envres.2010.06.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2016-01-06 N1 - SubjectsTermNotLitGenreText - Age; Prenatal experience; Data processing; Body height; Lipids; DDE; Bone growth; Metabolites; Children; Models; Birth; Standard deviation; DDT; Sodium lauryl sulfate; Body mass index; prenatal experience; Insecticides; Nitrous oxide; body mass; Mexico; Mexico, Chiapas DO - http://dx.doi.org/10.1016/j.envres.2010.06.001 ER - TY - JOUR T1 - Immigration, Health Care Access, and Recent Cancer Tests Among Mexican-Americans in California AN - 758108697; 201027587 AB - Immigrants' lower rates of cancer testing may be due to lack of fluency in English and other skills and knowledge about navigating US health care markets, lack of access to health services, or both. We analyzed 9,079 Mexican-American respondents to the 2001 California Health Interview Survey (CHIS) grouped as born in the US, living in the US 10 or more years, or living in the US less than 10years. The CHIS provides the largest Mexican-American sample in a US survey. Access to care meant having health insurance coverage and a usual source of care. English proficiency meant the respondent took the interview in English. Multivariate logistic regression was used to predict outcomes. Respondents reporting more time in the US were more likely to report access to medical care and to report getting a cancer screening exam. Regardless of time in the US, respondents reporting access had similar test rates. Regression results indicate that time in the US and primary language were not significant relative to use of cancer screening tests, but access to care was. Cancer screening tests that are covered by Every Woman Counts, California's breast and cervical cancer early detection program, had smaller gaps among groups than colorectal cancer screening which is not covered by a program. California is the only state with a survey able to monitor changes in small population groups. Understanding barriers specific to subgroups is key to developing appropriate policy and interventions to increase use of cancer screening exams. Adapted from the source document. JF - Journal of Immigrant and Minority Health AU - Breen, Nancy AU - Rao, Sowmya R AU - Meissner, Helen I AD - Health Services and Economics Branch, Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Executive Plaza North, Room 4005, 6130 Executive Blvd., MSC 7344, Rockville, MD, 20892-7344, USA Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 433 EP - 444 PB - Springer, Dordrecht The Netherlands VL - 12 IS - 4 SN - 1557-1912, 1557-1912 KW - Mexican American people KW - Screening KW - Health care KW - Breast cancer KW - Service provision KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758108697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immigrant+and+Minority+Health&rft.atitle=Immigration%2C+Health+Care+Access%2C+and+Recent+Cancer+Tests+Among+Mexican-Americans+in+California&rft.au=Breen%2C+Nancy%3BRao%2C+Sowmya+R%3BMeissner%2C+Helen+I&rft.aulast=Breen&rft.aufirst=Nancy&rft.date=2010-08-01&rft.volume=12&rft.issue=4&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immigrant+and+Minority+Health&rft.issn=15571912&rft_id=info:doi/10.1007%2Fs10903-008-9198-3 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Cancer; Screening; Mexican American people; Health care; Service provision; Breast cancer DO - http://dx.doi.org/10.1007/s10903-008-9198-3 ER - TY - JOUR T1 - Replacement Gene Therapy with a Human RPGRIP1 Sequence Slows Photoreceptor Degeneration in a Murine Model of Leber Congenital Amaurosis AN - 755141375; 13674109 AB - RPGR-interacting protein-1 (RPGRIP1) is localized in the photoreceptor-connecting cilium, where it anchors the RPGR (retinitis pigmentosa GTPase regulator) protein, and its function is essential for photoreceptor maintenance. Genetic defect in RPGRIP1 is a known cause of Leber congenital amaurosis (LCA), a severe, early-onset form of retinal degeneration. We evaluated the efficacy of replacement gene therapy in a murine model of LCA carrying a targeted disruption of RPGRIP1. The replacement construct, packaged in an adeno-associated virus serotype 8 (AAV8) vector, used a rhodopsin kinase gene promoter to drive RPGRIP1 expression. Both promoter and transgene were of human origin. After subretinal delivery of the replacement gene in the mutant mice, human RPGRIP1 was expressed specifically in photoreceptors, localized correctly in the connecting cilia, and restored the normal localization of RPGR. Electroretinogram and histological examinations showed better preservation of rod and cone photoreceptor function and improved photoreceptor survival in the treated eyes. This study demonstrates the efficacy of human gene replacement therapy and validates a gene therapy design for future clinical trials in patients afflicted with this condition. Our results also have therapeutic implications for other forms of retinal degenerations attributable to a ciliary defect. JF - Human Gene Therapy AU - Pawlyk, B S AU - Bulgakov, O V AU - Liu, X AU - Xu, X AU - Adamian, M AU - Sun, X AU - Khani, S C AU - Berson, EL AU - Sandberg, MA AU - Li, T AD - National Eye Institute, Bethesda, MD 20892, USA, Tiansen.Li@nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 993 EP - 1004 VL - 21 IS - 8 SN - 1043-0342, 1043-0342 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Age KW - Serotypes KW - Cones KW - retinal degeneration KW - Gene therapy KW - Transgenes KW - Animal models KW - Survival KW - Blindness KW - Cilia KW - Clinical trials KW - Adeno-associated virus KW - Photoreceptors KW - Expression vectors KW - Promoters KW - Electroretinograms KW - Rhodopsin kinase KW - Preservation KW - Retinitis pigmentosa KW - Guanosinetriphosphatase KW - W 30905:Medical Applications KW - V 22320:Replication KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755141375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Replacement+Gene+Therapy+with+a+Human+RPGRIP1+Sequence+Slows+Photoreceptor+Degeneration+in+a+Murine+Model+of+Leber+Congenital+Amaurosis&rft.au=Pawlyk%2C+B+S%3BBulgakov%2C+O+V%3BLiu%2C+X%3BXu%2C+X%3BAdamian%2C+M%3BSun%2C+X%3BKhani%2C+S+C%3BBerson%2C+EL%3BSandberg%2C+MA%3BLi%2C+T&rft.aulast=Pawlyk&rft.aufirst=B&rft.date=2010-08-01&rft.volume=21&rft.issue=8&rft.spage=993&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2009.218 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Age; Cones; Serotypes; Gene therapy; retinal degeneration; Transgenes; Animal models; Survival; Blindness; Clinical trials; Cilia; Photoreceptors; Expression vectors; Promoters; Electroretinograms; Rhodopsin kinase; Preservation; Retinitis pigmentosa; Guanosinetriphosphatase; Adeno-associated virus DO - http://dx.doi.org/10.1089/hum.2009.218 ER - TY - JOUR T1 - Role of CCL3/MIP-1a and CCL5/RANTES during acute Trypanosoma cruzi infection in rats AN - 755128480; 13400328 AB - Chagas' disease is caused by Trypanosoma cruzi infection and is characterized by chronic fibrogenic inflammation and heart dysfunction. Chemokines are produced during infection and drive tissue inflammation. In rats, acute infection is characterized by intense myocarditis and regression of inflammation after control of parasitism. We investigated the role of CCL3 and CCL5 during infection by using DNA vaccination encoding for each chemokine separately or simultaneously. MetRANTES treatment was used to evaluate the role of CCR1 and CCR5, the receptors for CCL3 and CCL5. Vaccination with CCL3 or CCL5 increased heart parasitism and decreased local IFN-g production, but did not influence intensity of inflammation. Simultaneous treatment with both plasmids or treatment with MetRANTES enhanced cardiac inflammation, fibrosis and parasitism. In conclusion, chemokines CCL3 and CCL5 are relevant, but not essential, for control of T. cruzi infection in rats. On the other hand, combined blockade of these chemokines or their receptors enhanced tissue inflammation and fibrosis, clearly contrasting with available data in murine models of T. cruzi infection. These data reinforce the important role of chemokines during T. cruzi infection but suggest that caution must be taken when expanding the therapeutic modulation of the chemokine system in mice to the human infection. JF - Microbes and Infection AU - Roffe, Ester AU - Oliveira, Fabiano AU - Souza, Adriano LS AU - Pinho, Vanessa AU - Souza, Danielle G AU - Souza, Patricia RS AU - Russo, Remo C AU - Santiago, Helton C AU - Romanha, Alvaro J AU - Tanowitz, Herbert B AU - Valenzuela, Jesus G AU - Teixeira, Mauro M AD - Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil, roffeest@niaid.nih.gov roffeest@niaid.nih.gov roffeest@niaid.nih.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 669 EP - 676 PB - Editions Scientifiques et Medicales Elsevier, 23 rue Linois 75724 Paris cedex 15 France VL - 12 IS - 8-9 SN - 1286-4579, 1286-4579 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Chemokines KW - CCR5 KW - Myocarditis KW - Fibrosis KW - Animal models KW - Disease control KW - CCR5 protein KW - Parasitism KW - Public health KW - CC chemokine receptors KW - CCR1 protein KW - DNA vaccines KW - Heart diseases KW - Heart KW - Trypanosoma cruzi KW - g-Interferon KW - Data processing KW - macrophage inflammatory protein 1 KW - CCL3 protein KW - Receptors KW - RANTES KW - Plasmids KW - Vaccination KW - Inflammation KW - Chronic infection KW - DNA KW - Chagas' disease KW - K 03350:Immunology KW - Q1 08484:Species interactions: parasites and diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755128480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbes+and+Infection&rft.atitle=Role+of+CCL3%2FMIP-1a+and+CCL5%2FRANTES+during+acute+Trypanosoma+cruzi+infection+in+rats&rft.au=Roffe%2C+Ester%3BOliveira%2C+Fabiano%3BSouza%2C+Adriano+LS%3BPinho%2C+Vanessa%3BSouza%2C+Danielle+G%3BSouza%2C+Patricia+RS%3BRusso%2C+Remo+C%3BSantiago%2C+Helton+C%3BRomanha%2C+Alvaro+J%3BTanowitz%2C+Herbert+B%3BValenzuela%2C+Jesus+G%3BTeixeira%2C+Mauro+M&rft.aulast=Roffe&rft.aufirst=Ester&rft.date=2010-08-01&rft.volume=12&rft.issue=8-9&rft.spage=669&rft.isbn=&rft.btitle=&rft.title=Microbes+and+Infection&rft.issn=12864579&rft_id=info:doi/10.1016%2Fj.micinf.2010.04.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Heart; DNA; Receptors; Disease control; Plasmids; Vaccination; Parasitism; Public health; Chemokines; Data processing; g-Interferon; Fibrosis; macrophage inflammatory protein 1; CCL3 protein; Animal models; RANTES; CCR5 protein; Inflammation; CC chemokine receptors; DNA vaccines; CCR1 protein; Chronic infection; Myocarditis; Chagas' disease; Heart diseases; Trypanosoma cruzi DO - http://dx.doi.org/10.1016/j.micinf.2010.04.011 ER - TY - JOUR T1 - Testing multiple gene interactions by the ordered combinatorial partitioning method in case-control studies AN - 754885237; 13440036 AB - Motivation: The multifactor-dimensionality reduction (MDR) method has been widely used in multi-locus interaction analysis. It reduces dimensionality by partitioning the multi-locus genotypes into a high-risk group and a low-risk group according to whether the genotype-specific risk ratio exceeds a fixed threshold or not. Alternatively, one can maximize the j super(2) value exhaustively over all possible ways of partitioning the multi-locus genotypes into two groups, and we aim to show that this is computationally feasible.Methods: We advocate finding the optimal MDR (OMDR) that would have resulted from an exhaustive search over all possible ways of partitioning the multi-locus genotypes into two groups. It is shown that this optimal MDR can be obtained efficiently using an ordered combinatorial partitioning (OCP) method, which differs from the existing MDR method in the use of a data-driven rather than fixed threshold. The generalized extreme value distribution (GEVD) theory is applied to find the optimal order of gene combination and assess statistical significance of interactions.Results: The computational complexity of OCP strategy is linear in the number of multi-locus genotypes in contrast with an exponential order for the naive exhaustive search strategy. Simulation studies show that OMDR can be more powerful than MDR with substantial power gain possible when the partitioning of OMDR is different from that of MDR. The analysis results of a breast cancer dataset show that the use of GEVD accelerates the determination of interaction order and reduces the time cost for P-value calculation by more than 10-fold. JF - Bioinformatics AU - Hua, Xing AU - Zhang, Han AU - Zhang, Hong AU - Yang, Yaning AU - Kuk, Anthony YC AD - super(1)Department of Statistics and Finance, University of Science and Technology of China, Hefei, Anhui 230026, China, super(2)Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA and super(3)Department of Statistics and Applied Probability, National University of Singapore, Singapore 117546 Y1 - 2010/08/01/ PY - 2010 DA - 2010 Aug 01 SP - 1871 EP - 1878 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 26 IS - 15 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Statistics KW - Data processing KW - Risk factors KW - Risk groups KW - Breast cancer KW - Genotypes KW - Bioinformatics KW - Computer applications KW - Internet KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754885237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Testing+multiple+gene+interactions+by+the+ordered+combinatorial+partitioning+method+in+case-control+studies&rft.au=Hua%2C+Xing%3BZhang%2C+Han%3BZhang%2C+Hong%3BYang%2C+Yaning%3BKuk%2C+Anthony+YC&rft.aulast=Hua&rft.aufirst=Xing&rft.date=2010-08-01&rft.volume=26&rft.issue=15&rft.spage=1871&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtq290 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Computer programs; Data processing; Statistics; Risk factors; Breast cancer; Risk groups; Bioinformatics; Genotypes; Computer applications; Internet DO - http://dx.doi.org/10.1093/bioinformatics/btq290 ER - TY - JOUR T1 - Learning transcriptional networks from the integration of ChIP-chip and expression data in a non-parametric model AN - 754884544; 13440051 AB - Results: We have developed LeTICE (Learning Transcriptional networks from the Integration of ChIP-chip and Expression data), an algorithm for learning a transcriptional network from ChIP-chip and expression data. The network is specified by a binary matrix of transcription factor (TF)-gene interactions partitioning genes into modules and a background of genes that are not involved in the transcriptional regulation. We define a likelihood of a network, and then search for the network optimizing the likelihood.We applied LeTICE to the location and expression data from yeast cells grown in rich media to learn the transcriptional network specific to the yeast cell cycle. It found 12 condition-specific TFs and 15 modules each of which is highly represented with functions related to particular phases of cell-cycle regulation. JF - Bioinformatics AU - Youn, Ahrim AU - Reiss, David J AU - Stuetzle, Werner AD - super(1)National Cancer Institute, Bethesda, MD, super(2)Institute for Systems Biology and super(3)Department of Statistics, University of Washington, Seattle, WA, USA Y1 - 2010/08/01/ PY - 2010 DA - 2010 Aug 01 SP - 1879 EP - 1886 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 26 IS - 15 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Integration KW - Learning KW - Data processing KW - Transcription factors KW - Gene regulation KW - Cell cycle KW - Algorithms KW - Bioinformatics KW - Internet KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754884544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Learning+transcriptional+networks+from+the+integration+of+ChIP-chip+and+expression+data+in+a+non-parametric+model&rft.au=Youn%2C+Ahrim%3BReiss%2C+David+J%3BStuetzle%2C+Werner&rft.aulast=Youn&rft.aufirst=Ahrim&rft.date=2010-08-01&rft.volume=26&rft.issue=15&rft.spage=1879&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtq289 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Integration; Computer programs; Learning; Data processing; Gene regulation; Transcription factors; Cell cycle; Algorithms; Bioinformatics; Internet DO - http://dx.doi.org/10.1093/bioinformatics/btq289 ER - TY - JOUR T1 - Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohorts AN - 754883821; 13418920 AB - Objective: To investigate whether the positive association of body mass index (BMI, kg/m super(2)) with risk of pancreatic cancer is modified by age, sex, smoking status, physical activity, and history of diabetes. Methods: In a pooled analysis of primary data of seven prospective cohorts including 458,070 men and 485,689 women, we identified 2,454 patients with incident pancreatic cancer during an average 6.9years of follow-up. Cox proportional hazard regression models were used in data analysis. Results: In a random-effects meta-analysis, for every 5kg/m super(2) increment in BMI, the summary relative risk (RR) was 1.06 (95% confidence interval (CI) 0.99-1.13) for men and 1.12 (95% CI 1.05-1.19) for women. The aggregate analysis showed that compared with normal weight (BMI: 18.5 to <25), the adjusted RR was 1.13 (95% CI 1.03-1.23) for overweight (BMI: 25 to <30) and 1.19 (95% CI 1.05-1.35) for obesity class I (BMI: 30 to <35). Tests of interactions of BMI effects by other risk factors were not statistically significant. Every 5kg/m super(2) increment in BMI was associated with an increased risk of pancreatic cancer among never and former smokers, but not among current smokers (P-interaction=0.08). Conclusion: The present evidence suggests that a high BMI is an independent risk factor of pancreatic cancer. JF - Cancer Causes & Control AU - Jiao, Li AU - Berrington de Gonzalez, Amy AU - Hartge, Patricia AU - Pfeiffer, Ruth M AU - Park, Yikyung AU - Freedman, DMichal AU - Gail, Mitchell H AU - Alavanja, Michael CR AU - Albanes, Demetrius AU - Beane Freeman, Laura E AU - Chow, Wong-Ho AU - Huang, Wen-Yi AU - Hayes, Richard B AU - Hoppin, Jane A AU - Ji, Bu-tian AU - Leitzmann, Michael F AU - Linet, Martha S AU - Meinhold, Cari L AU - Schairer, Catherine AU - Schatzkin, Arthur AU - Virtamo, Jarmo AU - Weinstein, Stephanie J AU - Zheng, Wei AU - Stolzenberg-Solomon, Rachael Z AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, jiao@bcm.edu jiao@bcm.edu jiao@bcm.edu jiao@bcm.edu jiao@bcm.edu jiao@bcm.edu jiao@bcm.edu jiao@bcm.edu jiao@bcm.edu jiao@bcm.edu Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1305 EP - 1314 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 21 IS - 8 SN - 0957-5243, 0957-5243 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Historical account KW - Smoking KW - pancreatic cancer KW - diabetes mellitus KW - Age KW - body mass KW - obesity KW - physical activity KW - Cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754883821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Body+mass+index%2C+effect+modifiers%2C+and+risk+of+pancreatic+cancer%3A+a+pooled+study+of+seven+prospective+cohorts&rft.au=Jiao%2C+Li%3BBerrington+de+Gonzalez%2C+Amy%3BHartge%2C+Patricia%3BPfeiffer%2C+Ruth+M%3BPark%2C+Yikyung%3BFreedman%2C+DMichal%3BGail%2C+Mitchell+H%3BAlavanja%2C+Michael+CR%3BAlbanes%2C+Demetrius%3BBeane+Freeman%2C+Laura+E%3BChow%2C+Wong-Ho%3BHuang%2C+Wen-Yi%3BHayes%2C+Richard+B%3BHoppin%2C+Jane+A%3BJi%2C+Bu-tian%3BLeitzmann%2C+Michael+F%3BLinet%2C+Martha+S%3BMeinhold%2C+Cari+L%3BSchairer%2C+Catherine%3BSchatzkin%2C+Arthur%3BVirtamo%2C+Jarmo%3BWeinstein%2C+Stephanie+J%3BZheng%2C+Wei%3BStolzenberg-Solomon%2C+Rachael+Z&rft.aulast=Jiao&rft.aufirst=Li&rft.date=2010-08-01&rft.volume=21&rft.issue=8&rft.spage=1305&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-010-9558-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Smoking; Historical account; Age; diabetes mellitus; pancreatic cancer; body mass; obesity; physical activity; Cancer DO - http://dx.doi.org/10.1007/s10552-010-9558-x ER - TY - JOUR T1 - Metabolic syndrome and risk of death from cancers of the digestive system AN - 754880793; 13400017 AB - We tested the hypothesis that risk of early mortality from cancers of the digestive system will be greater in men with, compared with men without, the metabolic syndrome (MetS). Participants were 33 230 men who were seen at the Cooper Clinic in Dallas, TX, and followed for 14.4 (SD = 7.0) years. Metabolic syndrome was defined as having at least 3 of the following risk factors: abdominal obesity, fasting hypertriglyceridemia, low high-density lipoprotein cholesterol, high blood pressure, or high fasting glucose level or diabetes. Metabolic syndrome was associated with higher mortality (hazard ratio [HR] = 1.90 [95% confidence interval = 1.42-2.55]), and there was a graded positive association for the addition of more syndrome components (P < .01). Adjustment for cardiorespiratory fitness attenuated the risk estimates by 20% to 30%, but they remained significant after this adjustment. Evaluation of the independent contribution of each of the syndrome components revealed that both abdominal obesity (HR = 1.89 [1.36-2.62]) and high glucose (HR = 1.38 [1.02-1.87]) were independently associated with cancer mortality. Our results support the hypothesis that metabolic syndrome is positively associated with mortality from cancers of the digestive system. Interventions that reduce abnormalities associated with the syndrome could reduce risk of premature death from these cancers. JF - Metabolism AU - Matthews, Charles E AU - Sui, Xuemei AU - LaMonte, Michael J AU - Adams, Swann A AU - Hebert, James R AU - Blair, Steven N AD - Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, National Cancer Institute, Rockville, MD 20892-7344, USA, charles.matthews2@nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1231 EP - 1239 PB - W.B. Saunders Company, Periodicals Order Fulfillment Dept. Orlando, FL 32887-4800 USA VL - 59 IS - 8 SN - 0026-0495, 0026-0495 KW - Toxicology Abstracts KW - Cancer KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754880793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolism&rft.atitle=Metabolic+syndrome+and+risk+of+death+from+cancers+of+the+digestive+system&rft.au=Matthews%2C+Charles+E%3BSui%2C+Xuemei%3BLaMonte%2C+Michael+J%3BAdams%2C+Swann+A%3BHebert%2C+James+R%3BBlair%2C+Steven+N&rft.aulast=Matthews&rft.aufirst=Charles&rft.date=2010-08-01&rft.volume=59&rft.issue=8&rft.spage=1231&rft.isbn=&rft.btitle=&rft.title=Metabolism&rft.issn=00260495&rft_id=info:doi/10.1016%2Fj.metabol.2009.11.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Cancer DO - http://dx.doi.org/10.1016/j.metabol.2009.11.019 ER - TY - JOUR T1 - Health Insurance and Cardiovascular Disease Risk Factors AN - 754565804; 13405581 AB - Compared with those with health insurance, the uninsured receive less care for chronic conditions, such as hypertension and diabetes, and experience higher mortality. Methods - We investigated the relations of health insurance status to the prevalence, treatment, and control of major cardiovascular disease risk factors - hypertension and elevated low-density lipoprotein (LDL) cholesterol - among Framingham Heart Study (FHS) participants in gender-specific, age-adjusted analyses. Participants who attended the seventh Offspring cohort examination cycle (1998-2001) or the first Third Generation cohort examination cycle (2002-2005) were studied. Results - Among 6098 participants, 3.8% were uninsured at the time of the FHS clinic examination and ages ranged from 19 to 64 years. The prevalence of hypertension and elevated LDL cholesterol was similar for the insured and uninsured; however, the proportion of those who obtained treatment and achieved control of these risk factors was lower among the uninsured. Uninsured men and women were less likely to be treated for hypertension with odds ratios for treatment of 0.19 (95% confidence interval [CI], 0.07-0.56) for men and 0.31 (95% CI, 0.12-0.79) for women. Among men, the uninsured were less likely to receive treatment or achieve control of elevated LDL cholesterol than the insured, with odds ratios of 0.12 (95% CI, 0.04-0.38) for treatment and 0.17 (95% CI, 0.05-0.56) for control. Conclusion - The treatment and control of hypertension and hypercholesterolemia are lower among uninsured adults. Increasing the proportion of insured individuals may be a means to improve the treatment and control of cardiovascular disease risk factors and to reduce health disparities. JF - American Journal of Medicine AU - Brooks, Erica L AU - Preis, Sarah Rosner AU - Hwang, Shih-Jen AU - Murabito, Joanne M AU - Benjamin, Emelia J AU - Kelly-Hayes, Margaret AU - Sorlie, Paul AU - Levy, Daniel AD - The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Mass, levyd@nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 741 EP - 747 PB - Elsevier BV, PO Box 10670 Riverton, NJ 08076 USA VL - 123 IS - 8 SN - 0002-9343, 0002-9343 KW - Risk Abstracts KW - Age KW - hypertension KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754565804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Medicine&rft.atitle=Health+Insurance+and+Cardiovascular+Disease+Risk+Factors&rft.au=Brooks%2C+Erica+L%3BPreis%2C+Sarah+Rosner%3BHwang%2C+Shih-Jen%3BMurabito%2C+Joanne+M%3BBenjamin%2C+Emelia+J%3BKelly-Hayes%2C+Margaret%3BSorlie%2C+Paul%3BLevy%2C+Daniel&rft.aulast=Brooks&rft.aufirst=Erica&rft.date=2010-08-01&rft.volume=123&rft.issue=8&rft.spage=741&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Medicine&rft.issn=00029343&rft_id=info:doi/10.1016%2Fj.amjmed.2010.02.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - hypertension DO - http://dx.doi.org/10.1016/j.amjmed.2010.02.013 ER - TY - JOUR T1 - Design and Implementation of the Hispanic Community Health Study/Study of Latinos AN - 754565398; 13407180 AB - Purpose - The Hispanic Community Health Study (HCHS)/Study of Latinos (SOL) is a comprehensive multicenter community based cohort study of Hispanics/Latinos in the United States. Methods - The Study rationale, objectives, design, and implementation are described in this report. Results - The HCHS/SOL will recruit 16,000 men and women who self-identify as Hispanic or Latino, 18 to 74 years of age, from a random sample of households in defined communities in the Bronx, Chicago, Miami, and San Diego. The sites were selected so that the overall sample would consist of at least 2000 persons in each of the following origin designations: Mexican, Puerto Rican and Dominican, Cuban, and Central and South American. The study includes research in the prevalence of and risk factors for heart, lung, blood and sleep disorders, kidney and liver function, diabetes, cognitive function, dental conditions, and hearing disorders. Conclusions - The HCHS/SOL will (1) characterize the health status and disease burden in the largest minority population in the United States; (2) describe the positive and negative consequences of immigration and acculturation of Hispanics/Latinos to the mainstream United States life-styles, environment and health care opportunities; and (3) identify likely causal factors of many diseases in a population with diverse environmental exposures, genetic backgrounds, and early life experiences. JF - Annals of Epidemiology AU - Sorlie, Paul D AU - Aviles-Santa, Larissa M AU - Wassertheil-Smoller, Sylvia AU - Kaplan, Robert C AU - Daviglus, Martha L AU - Giachello, Aida L AU - Schneiderman, Neil AU - Raij, Leopoldo AU - Talavera, Gregory AU - Allison, Matthew AU - LaVange, Lisa AU - Chambless, Lloyd E AU - Heiss, Gerardo AD - Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, SorlieP@mail.nih.gov SorlieP@mail.nih.gov SorlieP@mail.nih.gov SorlieP@mail.nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 629 EP - 641 PB - Elsevier Science, Box 882 New York NY 10159 USA VL - 20 IS - 8 SN - 1047-2797, 1047-2797 KW - Sustainability Science Abstracts; Risk Abstracts KW - USA, Illinois, Chicago KW - Age KW - USA, California, San Diego KW - households KW - diabetes mellitus KW - USA, Florida, Miami KW - Ethnic groups KW - Immigration KW - community involvement KW - Design KW - USA KW - cognitive ability KW - Health care KW - Lung KW - hexachlorocyclohexane KW - Liver KW - Kidney KW - M3 1010:Issues in Sustainable Development KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754565398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Design+and+Implementation+of+the+Hispanic+Community+Health+Study%2FStudy+of+Latinos&rft.au=Sorlie%2C+Paul+D%3BAviles-Santa%2C+Larissa+M%3BWassertheil-Smoller%2C+Sylvia%3BKaplan%2C+Robert+C%3BDaviglus%2C+Martha+L%3BGiachello%2C+Aida+L%3BSchneiderman%2C+Neil%3BRaij%2C+Leopoldo%3BTalavera%2C+Gregory%3BAllison%2C+Matthew%3BLaVange%2C+Lisa%3BChambless%2C+Lloyd+E%3BHeiss%2C+Gerardo&rft.aulast=Sorlie&rft.aufirst=Paul&rft.date=2010-08-01&rft.volume=20&rft.issue=8&rft.spage=629&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2010.03.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Age; Immigration; community involvement; Design; diabetes mellitus; households; cognitive ability; Health care; Lung; hexachlorocyclohexane; Kidney; Liver; Ethnic groups; USA, Illinois, Chicago; USA, California, San Diego; USA; USA, Florida, Miami DO - http://dx.doi.org/10.1016/j.annepidem.2010.03.015 ER - TY - JOUR T1 - Subdomain 3 of Plasmodium falciparum VAR2CSA DBL3x Is Identified as a Minimal Chondroitin Sulfate A-binding Region AN - 754560740; 13370423 AB - Molecular interactions between the VAR2CSA protein, expressed on the surface of Plasmodium falciparum-infected erythrocytes, and placental chondroitin sulfate A (CSA) are primarily responsible for pregnancy-associated malaria (PAM). Interrupting these interactions may prevent or ameliorate the severity of PAM. Several of the Duffy binding-like (DBL) domains of VAR2CSA, including the DBL3x domain, have been shown to bind CSA in vitro, but a more detailed understanding of how DBL domains bind CSA is needed. In this study, we demonstrate that subdomain 3 (S3), one of the three subdomains of VAR2CSA DBL3x by itself, is the major contributor toward CSA binding. NMR spectroscopy and flow cytometry analyses show that S3 and the intact DBL3x domain bind CSA similarly. Mutations within the S3 portion of DBL3x markedly affect CSA binding. Both recombinant molecules, S3 and DBL3x, are recognized by antibodies in the plasma of previously pregnant women living in malaria-endemic regions of Mali, but much less so by plasma from men of the same regions. As the S3 sequence is highly conserved in all known VAR2CSA proteins expressed by different parasite isolates obtained from various malaria endemic areas of the world, the identification of S3 as an independent CSA-binding region provides a compelling molecular basis for designing interventions against PAM. JF - Journal of Biological Chemistry AU - Singh, Kavita AU - Gitti, Rossitza K AU - Diouf, Ababacar AU - Zhou, Hong AU - Gowda, DChanne AU - Miura, Kazutoyo AU - Ostazeski, Stanley A AU - Fairhurst, Rick M AU - Garboczi, David N AU - Long, Carole A AD - Structural Biology Section, Research Technologies Branch, NIAID, National Institutes of Health, Rockville, Maryland 20852 Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 24855 EP - 24862 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 285 IS - 32 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Parasites KW - Human diseases KW - Mali KW - Chondroitin sulfate KW - Mutations KW - Erythrocytes KW - Malaria KW - Plasmodium falciparum KW - Pregnancy KW - Public health KW - Flow cytometry KW - Recombinants KW - Antibodies KW - Endemic species KW - Magnetic resonance spectroscopy KW - Placenta KW - Conserved sequence KW - Mutation KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754560740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Subdomain+3+of+Plasmodium+falciparum+VAR2CSA+DBL3x+Is+Identified+as+a+Minimal+Chondroitin+Sulfate+A-binding+Region&rft.au=Singh%2C+Kavita%3BGitti%2C+Rossitza+K%3BDiouf%2C+Ababacar%3BZhou%2C+Hong%3BGowda%2C+DChanne%3BMiura%2C+Kazutoyo%3BOstazeski%2C+Stanley+A%3BFairhurst%2C+Rick+M%3BGarboczi%2C+David+N%3BLong%2C+Carole+A&rft.aulast=Singh&rft.aufirst=Kavita&rft.date=2010-08-01&rft.volume=285&rft.issue=32&rft.spage=24855&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M110.118612 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Recombinants; Flow cytometry; Parasites; Endemic species; Human diseases; Mutations; Erythrocytes; Malaria; Public health; Antibodies; Chondroitin sulfate; Placenta; Magnetic resonance spectroscopy; Conserved sequence; Mutation; Pregnancy; Plasmodium falciparum; Mali DO - http://dx.doi.org/10.1074/jbc.M110.118612 ER - TY - JOUR T1 - Evaluation of the Integrated Database Network System (IDNS) SmartGene Software for Analysis of 16S rRNA Gene Sequences for Identification of Nocardia Species AN - 754558998; 13359675 AB - 16S rRNA gene sequences of 102 Nocardia isolates were analyzed using the Integrated Database Network System (IDNS) SmartGene centroid database. A total of 76% of the isolates were correctly identified. Discordant identifications were due to inadequate centroid length (3 species), inaccurate or insufficient entries in the public databases (5 species), and heterogeneous sequences among members of a species (1 species). JF - Journal of Clinical Microbiology AU - Conville, Patricia S AU - Murray, Patrick R AU - Zelazny, Adrian M AD - Microbiology Service, Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, pconville@mail.nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 2995 EP - 2998 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 48 IS - 8 SN - 0095-1137, 0095-1137 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Databases KW - Computer programs KW - software KW - Nocardia KW - rRNA 16S KW - J 02310:Genetics & Taxonomy KW - N 14815:Nucleotide Sequence KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754558998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Evaluation+of+the+Integrated+Database+Network+System+%28IDNS%29+SmartGene+Software+for+Analysis+of+16S+rRNA+Gene+Sequences+for+Identification+of+Nocardia+Species&rft.au=Conville%2C+Patricia+S%3BMurray%2C+Patrick+R%3BZelazny%2C+Adrian+M&rft.aulast=Conville&rft.aufirst=Patricia&rft.date=2010-08-01&rft.volume=48&rft.issue=8&rft.spage=2995&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00681-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Computer programs; Databases; software; rRNA 16S; Nocardia DO - http://dx.doi.org/10.1128/JCM.00681-10 ER - TY - JOUR T1 - Mice Lacking Multidrug Resistance Protein 1a Show Altered Dopaminergic Responses to Methylenedioxymethamphetamine (MDMA) in Striatum AN - 754548870; 13306807 JF - Neurotoxicity Research AU - Scheidweiler, Karl B AU - Ladenheim, Bruce AU - Cadet, Jean Lud AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard Suite 200, Room 05A-721, Baltimore, MD 21224, USA, mhuestis@intra.nida.nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 200 EP - 209 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 18 IS - 2 SN - 1029-8428, 1029-8428 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Dopamine KW - Neurotoxicity KW - Neostriatum KW - Multidrug resistance KW - MDMA KW - X 24380:Social Poisons & Drug Abuse KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754548870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicity+Research&rft.atitle=Mice+Lacking+Multidrug+Resistance+Protein+1a+Show+Altered+Dopaminergic+Responses+to+Methylenedioxymethamphetamine+%28MDMA%29+in+Striatum&rft.au=Scheidweiler%2C+Karl+B%3BLadenheim%2C+Bruce%3BCadet%2C+Jean+Lud%3BHuestis%2C+Marilyn+A&rft.aulast=Scheidweiler&rft.aufirst=Karl&rft.date=2010-08-01&rft.volume=18&rft.issue=2&rft.spage=200&rft.isbn=&rft.btitle=&rft.title=Neurotoxicity+Research&rft.issn=10298428&rft_id=info:doi/10.1007%2Fs12640-009-9124-z L2 - http://www.springerlink.com/content/t238758v12425426/?p=805924f775e74650af3873db22c8a2fd&pi=9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Dopamine; Neostriatum; Neurotoxicity; Multidrug resistance; MDMA DO - http://dx.doi.org/10.1007/s12640-009-9124-z ER - TY - JOUR T1 - Polyphosphate binds to the principal sigma factor of RNA polymerase during starvation response in Helicobacter pylori AN - 754536920; 13247045 AB - SummaryHelicobacter pylori persists deep in the human gastric mucus layer in a harsh, nutrient-poor environment. Survival under these conditions depends on the ability of this human pathogen to invoke starvation/stress responses when needed. Unlike many bacteria, H. pylori lacks starvation/stress-responding alternative sigma factors, suggesting an additional mechanism might have evolved in this bacterium. Helicobacter pylori produces polyphosphate; however, the role and target of polyphosphate during starvation/stress have not been identified. Here we show that polyphosphate accumulated during nutrient starvation directly targets transcriptional machinery by binding to the principal sigma factor in H. pylori, uncovering a novel mechanism in microbial stress response. A positively charged Lys-rich region at the N-terminal domain of the major sigma factor is identified as the binding region for polyphosphate (region P) in vivo and in vitro, revealing a new element in sigma 70 family proteins. This interaction is biologically significant because mutant strains defective in the interaction undergo premature cell death during starvation. We suggested that polyphosphate is a second messenger employed by H. pylori to mediate gene expression during starvation/stress. The putative 'region P' is present in sigma factors of other human pathogens, suggesting that the uncovered interaction might be a general strategy employed by other pathogens. JF - Molecular Microbiology AU - Yang, Zhao Xu AU - Zhou, Yan Ning AU - Yang, Yi AU - Jin, Ding Jun AD - National Cancer Institute, National Institutes of Health, Frederick, MD, USA. Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 618 EP - 627 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 77 IS - 3 SN - 0950-382X, 0950-382X KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Starvation KW - Helicobacter pylori KW - Stress KW - Transcription KW - Mucus KW - Nutrients KW - Pathogens KW - Gene expression KW - Cell death KW - Second messengers KW - DNA-directed RNA polymerase KW - polyphosphates KW - Sigma factor KW - J 02410:Animal Diseases KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754536920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Polyphosphate+binds+to+the+principal+sigma+factor+of+RNA+polymerase+during+starvation+response+in+Helicobacter+pylori&rft.au=Yang%2C+Zhao+Xu%3BZhou%2C+Yan+Ning%3BYang%2C+Yi%3BJin%2C+Ding+Jun&rft.aulast=Yang&rft.aufirst=Zhao&rft.date=2010-08-01&rft.volume=77&rft.issue=3&rft.spage=618&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2010.07233.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Gene expression; Starvation; DNA-directed RNA polymerase; Second messengers; Cell death; polyphosphates; Transcription; Stress; Nutrients; Mucus; Pathogens; Sigma factor; Helicobacter pylori DO - http://dx.doi.org/10.1111/j.1365-2958.2010.07233.x ER - TY - JOUR T1 - Novel Protease Inhibitors (PIs) Containing Macrocyclic Components and 3(R),3a(S),6a(R)-bis-Tetrahydrofuranylurethane That Are Potent against Multi-PI-Resistant HIV-1 Variants In Vitro AN - 754533198; 13233380 AB - Natural products with macrocyclic structural features often display intriguing biological properties. Molecular design incorporating macrocycles may lead to molecules with unique protein-ligand interactions. We generated novel human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs) containing a macrocycle and bis-tetrahydrofuranylurethane. Four such compounds exerted potent activity against HIV-1LAI and had 50% effective concentrations (EC50s) of as low as 0.002 kM with minimal cytotoxicity. GRL-216 and GRL-286 blocked the replication of HIV-1NL4-3 variants selected by up to 5 kM saquinavir, ritonavir, nelfinavir, lopinavir, or atazanavir; they had EC50s of 0.020 to 0.046 kM and potent activities against six multi-PI-resistant clinical HIV-1 (HIVmPIr) variants with EC50s of 0.027 to 0.089 kM. GRL-216 and -286 also blocked HIV-1 protease dimerization as efficiently as darunavir. When HIV-1NL4-3 was selected by GRL-216, it replicated progressively more poorly and failed to replicate in the presence of >0.26 kM GRL-216, suggesting that the emergence of GRL-216-resistant HIV-1 variants is substantially delayed. At passage 50 with GRL-216 (the HIV isolate selected with GRL-216 at up to 0.16 kM [HIV216-0.16 kM]), HIV-1NL4-3 containing the L10I, L24I, M46L, V82I, and I84V mutations remained relatively sensitive to PIs, including darunavir, with the EC50s being 3- to 8-fold-greater than the EC50 of each drug for HIV-1NL4-3. Interestingly, HIV216-0.16 kM had 10-fold increased sensitivity to tipranavir. Analysis of the protein-ligand X-ray structures of GRL-216 revealed that the macrocycle occupied a greater volume of the binding cavity of protease and formed greater van der Waals interactions with V82 and I84 than darunavir. The present data warrant the further development of GRL-216 as a potential antiviral agent for treating individuals harboring wild-type and/or HIVmPIr. JF - Antimicrobial Agents & Chemotherapy AU - Tojo, Yasushi AU - Koh, Yasuhiro AU - Amano, Masayuki AU - Aoki, Manabu AU - Das, Debananda AU - Kulkarni, Sarang AU - Anderson, David D AU - Ghosh, Arun K AU - Mitsuya, Hiroaki AD - Departments of Hematology and Infectious Diseases, Kumamoto University Graduate School of Biomedical Sciences, Kumamoto 860-8556, Japan, hmitsuya@helix.nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 3460 EP - 3470 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 54 IS - 8 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Cavities KW - Data processing KW - Saquinavir KW - Replication KW - Proteinase inhibitors KW - natural products KW - Cytotoxicity KW - Lopinavir KW - Antiviral agents KW - Ritonavir KW - Ionizing radiation KW - Human immunodeficiency virus 1 KW - Nelfinavir KW - Mutation KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754533198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Novel+Protease+Inhibitors+%28PIs%29+Containing+Macrocyclic+Components+and+3%28R%29%2C3a%28S%29%2C6a%28R%29-bis-Tetrahydrofuranylurethane+That+Are+Potent+against+Multi-PI-Resistant+HIV-1+Variants+In+Vitro&rft.au=Tojo%2C+Yasushi%3BKoh%2C+Yasuhiro%3BAmano%2C+Masayuki%3BAoki%2C+Manabu%3BDas%2C+Debananda%3BKulkarni%2C+Sarang%3BAnderson%2C+David+D%3BGhosh%2C+Arun+K%3BMitsuya%2C+Hiroaki&rft.aulast=Tojo&rft.aufirst=Yasushi&rft.date=2010-08-01&rft.volume=54&rft.issue=8&rft.spage=3460&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.01766-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Cavities; Data processing; Replication; Saquinavir; Proteinase inhibitors; natural products; Cytotoxicity; Antiviral agents; Lopinavir; Ritonavir; Ionizing radiation; Nelfinavir; Mutation; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1128/AAC.01766-09 ER - TY - JOUR T1 - Microarray and Molecular Analyses of the Azole Resistance Mechanism in Candida glabrata Oropharyngeal Isolates AN - 754533162; 13233351 AB - DNA microarrays were used to analyze Candida glabrata oropharyngeal isolates from seven hematopoietic stem cell transplant recipients whose isolates developed azole resistance while the recipients received fluconazole prophylaxis. Transcriptional profiling of the paired isolates revealed 19 genes upregulated in the majority of resistant isolates compared to their paired susceptible isolates. All seven resistant isolates had greater than 2-fold upregulation of C. glabrata PDR1 (CgPDR1), a master transcriptional regulator of the pleiotropic drug resistance (PDR) network, and all seven resistant isolates showed upregulation of known CgPDR1 target genes. The altered transcriptome can be explained in part by the observation that all seven resistant isolates had acquired a single nonsynonymous mutation in their CgPDR1 open reading frame. Four mutations occurred in the regulatory domain (L280P, L344S, G348A, and S391L) and one in the activation domain (G943S), while two mutations (N764I and R772I) occurred in an undefined region. Association of azole resistance and the CgPDR1 mutations was investigated in the same genetic background by introducing the CgPDR1 sequences from one sensitive isolate and five resistant isolates into a laboratory azole-hypersusceptible strain (Cgpdr1 strain) via integrative transformation. The Cgpdr1 strain was restored to wild-type fluconazole susceptibility when transformed with CgPDR1 from the susceptible isolate but became resistant when transformed with CgPDR1 from the resistant isolates. However, despite the identical genetic backgrounds, upregulation of CgPDR1 and CgPDR1 target genes varied between the five transformants, independent of the domain locations in which the mutations occurred. In summary, gain-of-function mutations in CgPDR1 contributed to the clinical azole resistance, but different mutations had various degrees of impact on the CgPDR1 target genes. JF - Antimicrobial Agents & Chemotherapy AU - Tsai, Huei-Fung AU - Sammons, Lindsay R AU - Zhang, Xiaozhen AU - Suffis, Sara D AU - Su, Qin AU - Myers, Timothy G AU - Marr, Kieren A AU - Bennett, John E AD - Clinical Mycology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, Jbennett@niaid.nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 3308 EP - 3317 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 54 IS - 8 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Gene expression KW - Transformation KW - fluconazole KW - Drug resistance KW - Candida glabrata KW - Prophylaxis KW - Transcription KW - Mutation KW - DNA microarrays KW - azoles KW - Open reading frames KW - A 01340:Antibiotics & Antimicrobials KW - K 03400:Human Diseases KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754533162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Microarray+and+Molecular+Analyses+of+the+Azole+Resistance+Mechanism+in+Candida+glabrata+Oropharyngeal+Isolates&rft.au=Tsai%2C+Huei-Fung%3BSammons%2C+Lindsay+R%3BZhang%2C+Xiaozhen%3BSuffis%2C+Sara+D%3BSu%2C+Qin%3BMyers%2C+Timothy+G%3BMarr%2C+Kieren+A%3BBennett%2C+John+E&rft.aulast=Tsai&rft.aufirst=Huei-Fung&rft.date=2010-08-01&rft.volume=54&rft.issue=8&rft.spage=3308&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00535-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Transformation; Gene expression; fluconazole; Drug resistance; Prophylaxis; Transcription; DNA microarrays; Mutation; Open reading frames; azoles; Candida glabrata DO - http://dx.doi.org/10.1128/AAC.00535-10 ER - TY - JOUR T1 - Extracellular fluctuations of dopamine and glutamate in the nucleus accumbens core and shell associated with lever-pressing during cocaine self-administration, extinction, and yoked cocaine administration AN - 754533116; 13224252 AB - Rationale: Dopamine and glutamate in the nucleus accumbens (NAS) are differentially implicated in cocaine-directed behavior. Objectives: We sought to compare extracellular fluctuations of dopamine and glutamate in core and shell of NAS associated with operant responding during cocaine self-administration, extinction, and yoked cocaine administration. Methods: Rats were trained to lever-press for cocaine or saline under FR1 before undergoing microdialysis testing during cocaine self-administration, extinction, or yoked cocaine administration. Microdialysis samples were collected every 20min and were analyzed for dopamine and glutamate with high-performance liquid chromatography. Results: Rats actively lever-pressed during cocaine self-administration and extinction. However, lever-pressing was minimal during yoked cocaine administration in both cocaine-trained and saline-trained rats. Dopamine was elevated throughout cocaine self-administration and yoked cocaine administration. The extent of cocaine-evoked dopamine was greater in shell than in core, greater in cocaine-trained than in saline-trained rats, and greater during self-administration than during yoked administration. Dopamine was also elevated in core (first 60min) and in shell (first 40min) during extinction. Basal concentration of glutamate, but not dopamine, was lower in cocaine-trained than in saline-trained rats. In cocaine-trained rats, glutamate was elevated during cocaine self-administration and extinction but was depressed below baseline during yoked cocaine administration. The extent and direction of glutamate fluctuation was similar between core and shell. In saline-trained rats, glutamate was not affected by yoked cocaine. Conclusion: Distinct patterns of dopamine and glutamate fluctuations in core and shell appear to underlie characteristic patterns of lever-pressing associated with cocaine self-administration, extinction, and yoked cocaine administration. JF - Psychopharmacology AU - Suto, Nobuyoshi AU - Ecke, Laurel E AU - You, Zhi-Bing AU - Wise, Roy A AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Baltimore, MD, 21224, USA, nsuto@mprc.umaryland.edu Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 267 EP - 275 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany VL - 211 IS - 3 SN - 0033-3158, 0033-3158 KW - Toxicology Abstracts; CSA Neurosciences Abstracts; Animal Behavior Abstracts KW - Microdialysis KW - High-performance liquid chromatography KW - Nucleus accumbens KW - Dopamine KW - Extinction KW - Operant conditioning KW - Glutamic acid KW - Cocaine KW - Drug self-administration KW - Y 25150:General/Miscellaneous KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754533116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Extracellular+fluctuations+of+dopamine+and+glutamate+in+the+nucleus+accumbens+core+and+shell+associated+with+lever-pressing+during+cocaine+self-administration%2C+extinction%2C+and+yoked+cocaine+administration&rft.au=Suto%2C+Nobuyoshi%3BEcke%2C+Laurel+E%3BYou%2C+Zhi-Bing%3BWise%2C+Roy+A&rft.aulast=Suto&rft.aufirst=Nobuyoshi&rft.date=2010-08-01&rft.volume=211&rft.issue=3&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-010-1890-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Microdialysis; Nucleus accumbens; Dopamine; Operant conditioning; Extinction; Glutamic acid; Cocaine; Drug self-administration DO - http://dx.doi.org/10.1007/s00213-010-1890-z ER - TY - JOUR T1 - Coxiella burnetii Phase I and II Variants Replicate with Similar Kinetics in Degradative Phagolysosome-Like Compartments of Human Macrophages AN - 754531856; 13233412 AB - Coxiella burnetii infects mononuclear phagocytes, where it directs biogenesis of a vacuolar niche termed the parasitophorous vacuole (PV). Owing to its lumenal pH (5) and fusion with endolysosomal vesicles, the PV is considered phagolysosome-like. However, the degradative properties of the mature PV are unknown, and there are conflicting reports on the maturation state and growth permissiveness of PV harboring virulent phase I or avirulent phase II C. burnetii variants in human mononuclear phagocytes. Here, we employed infection of primary human monocyte-derived macrophages (HMDMs) and THP-1 cells as host cells to directly compare the PV maturation kinetics and pathogen growth in cells infected with the Nine Mile phase I variant (NMI) or phase II variant (NMII) of C. burnetii. In both cell types, phase variants replicated with similar kinetics, achieving roughly 2 to 3 log units of growth before they reached stationary phase. HMDMs infected by either phase variant secreted similar amounts of the proinflammatory cytokines interleukin-6 and tumor necrosis factor alpha. In infected THP-1 cells, equal percentages of NMI and NMII PVs decorate with the early endosomal marker Rab5, the late endosomal/lysosomal markers Rab7 and CD63, and the lysosomal marker cathepsin D at early (8 h) and late (72 h) time points postinfection (p.i.). Mature PVs (2 to 4 days p.i.) harboring NMI or NMII contained proteolytically active cathepsins and quickly degraded Escherichia coli. These data suggest that C. burnetii does not actively inhibit phagolysosome function as a survival mechanism. Instead, NMI and NMII resist degradation to replicate in indistinguishable digestive PVs that fully mature through the endolysosomal pathway. JF - Infection and Immunity AU - Howe, Dale AU - Shannon, Jeffrey G AU - Winfree, Seth AU - Dorward, David W AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, rheinzen@niaid.nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 3465 EP - 3474 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 78 IS - 8 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Interleukin 6 KW - Leukocytes (mononuclear) KW - Data processing KW - Cathepsin D KW - Niches KW - Survival KW - CD63 antigen KW - Pathogens KW - Tumor necrosis factor-a KW - Infection KW - Inflammation KW - stationary phase KW - parasitophorous vacuole KW - Coxiella burnetii KW - Phagolysosomes KW - Phagocytes KW - Kinetics KW - Escherichia coli KW - cathepsins KW - Monocytes KW - pH effects KW - Vesicle fusion KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754531856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Coxiella+burnetii+Phase+I+and+II+Variants+Replicate+with+Similar+Kinetics+in+Degradative+Phagolysosome-Like+Compartments+of+Human+Macrophages&rft.au=Howe%2C+Dale%3BShannon%2C+Jeffrey+G%3BWinfree%2C+Seth%3BDorward%2C+David+W%3BHeinzen%2C+Robert+A&rft.aulast=Howe&rft.aufirst=Dale&rft.date=2010-08-01&rft.volume=78&rft.issue=8&rft.spage=3465&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00406-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Macrophages; Leukocytes (mononuclear); Data processing; Cathepsin D; Niches; Survival; CD63 antigen; Pathogens; Infection; Tumor necrosis factor-a; Inflammation; parasitophorous vacuole; stationary phase; Phagolysosomes; Phagocytes; Kinetics; cathepsins; Monocytes; pH effects; Vesicle fusion; Coxiella burnetii; Escherichia coli DO - http://dx.doi.org/10.1128/IAI.00406-10 ER - TY - JOUR T1 - Phospholipid profile in the postmortem hippocampus of patients with schizophrenia and bipolar disorder: No changes in docosahexaenoic acid species AN - 754141804; 201025349 AB - Previous studies with postmortem brain tissues showed abnormalities not only in n-3 long-chain polyunsaturated fatty acids (PUFA) but also in phospholipid metabolism in the cortex of individuals with schizophrenia and mood disorder. In this study we investigated whether there is similar abnormality in n-3 long-chain PUFAs and/or in phospholipid profile in the hippocampus of schizophrenia and bipolar disorder patients compared to unaffected controls. Using high-performance liquid chromatography/electrospray ionization-mass spectrometry (LC/MS), the phospholipid contents in the postmortem hippocampus from 35 individuals with schizophrenia, 34 individuals with bipolar disorder and 35 controls were evaluated. Unlike the previous findings form orbitofrontal cortex, we found no significant differences in either n-3 long-chain PUFA or total phosphatidylserine (PS), phosphatidylethanolamine (PE) and phosphatidylcholine (PC). However, docosapentaenoic acid (n-6, 22:5n-6)-PS and 22:5n-6-PC were significantly lower in individuals with schizophrenia or bipolar disorder than the controls. When fatty acid contents were estimated from PS, PE and PC, 22:5n-6 was significantly lower in both patient groups compared to the controls. From these results we concluded that DHA loss associated with these psychiatric disorders may be specific to certain regions of the brain. The selective decrease in 22:5n-6 without affecting DHA contents suggests altered lipid metabolism, particularly n-6 PUFA rather than n-3 PUFA, in the hippocampus of individuals with schizophrenia or bipolar disorder. [Copyright Elsevier Ltd.] JF - Journal of Psychiatric Research AU - Hamazaki, Kei AU - Choi, Kwang H AU - Kim, Hee-Yong AD - Laboratory of Molecular Signaling, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 3N07, MSC9410, Bethesda, MD 20892-9410, USA keihama@med.u-toyama.ac.jp Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 688 EP - 693 PB - Elsevier Ltd, Oxford UK VL - 44 IS - 11 SN - 0022-3956, 0022-3956 KW - Bipolar disorder Schizophrenia Hippocampus Phospholipids Polyunsaturated fatty acids Postmortem brain KW - Schizophrenia KW - Postmortems KW - Cortex KW - Hippocampus KW - Bipolar affective disorder KW - Fatty acids KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754141804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychiatric+Research&rft.atitle=Phospholipid+profile+in+the+postmortem+hippocampus+of+patients+with+schizophrenia+and+bipolar+disorder%3A+No+changes+in+docosahexaenoic+acid+species&rft.au=Hamazaki%2C+Kei%3BChoi%2C+Kwang+H%3BKim%2C+Hee-Yong&rft.aulast=Hamazaki&rft.aufirst=Kei&rft.date=2010-08-01&rft.volume=44&rft.issue=11&rft.spage=688&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychiatric+Research&rft.issn=00223956&rft_id=info:doi/10.1016%2Fj.jpsychires.2009.11.017 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-09-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JPYRA3 N1 - SubjectsTermNotLitGenreText - Schizophrenia; Bipolar affective disorder; Hippocampus; Cortex; Postmortems; Fatty acids DO - http://dx.doi.org/10.1016/j.jpsychires.2009.11.017 ER - TY - JOUR T1 - Toward an information-motivation-behavioral skills model of microbicide adherence in clinical trials AN - 754141541; 201025115 AB - Unless optimal adherence in microbicide clinical trials is ensured, an efficacious microbicide may be rejected after trial completion, or development of a promising microbicide may be stopped, because low adherence rates create the illusion of poor efficacy. We provide a framework with which to conceptualize and improve microbicide adherence in clinical trials, supported by a critical review of the empirical literature. The information-motivation-behavioral skills (IMB) model of microbicide adherence conceptualizes microbicide adherence in clinical trials and highlights factors that can be addressed in behavioral interventions to increase adherence in such trials. This model asserts that microbicide adherence-related information, motivation, and behavioral skills are fundamental determinants of adherent microbicide utilization. Specifically, information consists of objective facts about microbicide use (e.g., administration and dosage) as well as heuristics that facilitate use (e.g., microbicides must be used with all partners). Motivation to adhere consists of attitudes toward personal use of microbicides (e.g., evaluating the consequences of using microbicides as good or pleasant) as well as social norms that support their use (e.g., beliefs that a sexual partner approves use of microbicides). Behavioral skills consist of objective skills necessary for microbicide adherence (e.g., the ability to apply the microbicide correctly and consistently). Empirical evidence concerning microbicide acceptability and adherence to spermicides, medication, and condom use regimens support the utility of this model for understanding and promoting microbicide adherence in clinical trials. Adapted from the source document. JF - AIDS Care AU - Ferrer, Rebecca A AU - Morrow, Kathleen M AU - Fisher, William A AU - Fisher, Jeffrey D AD - Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 997 EP - 1005 PB - Taylor & Francis, Abingdon UK VL - 22 IS - 8 SN - 0954-0121, 0954-0121 KW - Condoms KW - Safe sexual practices KW - Motivation KW - Illusions KW - Adherence KW - Clinical trials KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754141541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Care&rft.atitle=Toward+an+information-motivation-behavioral+skills+model+of+microbicide+adherence+in+clinical+trials&rft.au=Ferrer%2C+Rebecca+A%3BMorrow%2C+Kathleen+M%3BFisher%2C+William+A%3BFisher%2C+Jeffrey+D&rft.aulast=Ferrer&rft.aufirst=Rebecca&rft.date=2010-08-01&rft.volume=22&rft.issue=8&rft.spage=997&rft.isbn=&rft.btitle=&rft.title=AIDS+Care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540121003623719 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - AIDCEF N1 - SubjectsTermNotLitGenreText - Safe sexual practices; Adherence; Clinical trials; Motivation; Condoms; Illusions DO - http://dx.doi.org/10.1080/09540121003623719 ER - TY - JOUR T1 - Sensitivity designs for preventing bias replication in randomized clinical trials AN - 754141243; 201024479 AB - It is common, after a trial is completed, to employ sensitivity analyses to test the extent to which the results depend on various assumptions or conventions. There is a comparable benefit to employing sensitivity designs when planning a trial, so that features that cannot be varied at the analysis stage can instead be varied (e.g., across centres of a multi-centre trial) during the design stage. Design features amenable to such variation include: (1) the specific randomization methods, (2) the duration of follow-up and (3) the use or non-use of a surrogate endpoint as a replacement for a clinical endpoint. Generally, all centres in a given trial, and all trials in a given program, will employ identical protocols. This means that all will be vulnerable to the same types of biases, meaning that a single bias can by itself render all results unreliable. But by varying the randomization techniques, duration and primary endpoint, one can vary also the biases to which the site-specific results are vulnerable. This means that, if a significant result is found, then one can state that either the treatment worked or there were numerous biases (not just one) at play. This of course makes the attribution of the results to the treatments much more plausible and makes the findings much more robust to violations of assumptions. Adapted from the source document. JF - Statistical Methods in Medical Research AU - Berger, Vance W AU - Grant, William C AU - Vazquez, Laura F AD - NIH, Bethesda, MD, USA bergerv@mail.nih.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 415 EP - 424 PB - Hodder Arnold, London UK VL - 19 IS - 4 SN - 0962-2802, 0962-2802 KW - Sensitivity KW - Sensitivity analysis KW - Violations KW - Surrogates KW - Bias KW - Randomization KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754141243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Sensitivity+designs+for+preventing+bias+replication+in+randomized+clinical+trials&rft.au=Berger%2C+Vance+W%3BGrant%2C+William+C%3BVazquez%2C+Laura+F&rft.aulast=Berger&rft.aufirst=Vance&rft.date=2010-08-01&rft.volume=19&rft.issue=4&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280209359875 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Randomization; Sensitivity; Bias; Sensitivity analysis; Surrogates; Violations DO - http://dx.doi.org/10.1177/0962280209359875 ER - TY - JOUR T1 - Psychopathy, frustration, and reactive aggression: The role of ventromedial prefrontal cortex AN - 754135129; 201019960 AB - Psychopathy is a developmental disorder marked by emotional hyporesponsiveness and an increased risk for instrumental and reactive aggression. The increased risk for reactive aggression is the focus of the current paper. It will be argued that the increased risk for reactive aggression does not relate to an increased sensitivity to threatening stimuli since psychopathy is associated with a reduced sensitivity to threat. Instead, it is argued that the increased risk for reactive aggression relates to an increased risk for frustration; i.e., the emotional state following the performance of an action in the expectation of a particular reward and not receiving this reward. Two impairments seen in psychopathy would increase the risk for frustration and consequent potential reactive aggression; impairments in stimulus-reinforcement learning and reversal learning. It is argued that both are known consequences of impairment in ventromedial prefrontal cortex, one of the regions principally implicated in psychopathy. Adapted from the source document. JF - British Journal of Psychology AU - Blair, R J R AD - Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 383 EP - 399 PB - The British Psychological Society, Leicester UK VL - 101 IS - 3 SN - 0007-1269, 0007-1269 KW - Sensitivity KW - Learning KW - Psychopathy KW - Frustration KW - Rewards KW - Aggression KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754135129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Psychology&rft.atitle=Psychopathy%2C+frustration%2C+and+reactive+aggression%3A+The+role+of+ventromedial+prefrontal+cortex&rft.au=Blair%2C+R+J+R&rft.aulast=Blair&rft.aufirst=R+J&rft.date=2010-08-01&rft.volume=101&rft.issue=3&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Psychology&rft.issn=00071269&rft_id=info:doi/10.1348%2F000712609X418480 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - BJSGAE N1 - SubjectsTermNotLitGenreText - Aggression; Psychopathy; Frustration; Learning; Sensitivity; Rewards DO - http://dx.doi.org/10.1348/000712609X418480 ER - TY - JOUR T1 - Reactive aggression and functional, not neural, specificity AN - 754135051; 201019961 AB - This article is an author response to Harenski and Kiehl's (2010) commentary on Blair (2010). Adapted from the source document. JF - British Journal of Psychology AU - Blair, R J R AD - Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 407 EP - 410 PB - The British Psychological Society, Leicester UK VL - 101 IS - 3 SN - 0007-1269, 0007-1269 KW - Aggression KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754135051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Psychology&rft.atitle=Reactive+aggression+and+functional%2C+not+neural%2C+specificity&rft.au=Blair%2C+R+J+R&rft.aulast=Blair&rft.aufirst=R+J&rft.date=2010-08-01&rft.volume=101&rft.issue=3&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Psychology&rft.issn=00071269&rft_id=info:doi/10.1348%2F000712610X512122 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - BJSGAE N1 - SubjectsTermNotLitGenreText - Aggression DO - http://dx.doi.org/10.1348/000712610X512122 ER - TY - JOUR T1 - Excretion of methadone in sweat of pregnant women throughout gestation after controlled methadone administration. AN - 749026111; 20592651 AB - Sweat patches (n = 350) were collected throughout gestation from 29 opioid-dependent pregnant women participating in an outpatient methadone-assisted therapy program. Volunteers provided informed consent to participate in institutional review board-approved protocols. Methadone was eluted from sweat patches with sodium acetate buffer, followed by solid-phase extraction and quantification by gas chromatography mass spectrometry (limit of quantification > or = 10 ng/patch). Methadone was present in all weekly patches (n = 311) in concentrations ranging from 10.2 to 12,129.7 nanograms per patch and in 92.3% of short-term patches (n = 39, worn for 12 or 24 hours) in concentrations up to 3303.9 nanograms per patch. Correlation between patch concentrations and total amount of drug administered (r = 0.224), and concentrations and duration of patch wear (r = 0.129) were both weak. Although there were large intra- and intersubject variations in sweat drug concentrations, sweat testing was an effective alternative technique to qualitatively monitor illicit drug use and simultaneously document methadone medication-assisted treatment. JF - Therapeutic drug monitoring AU - Barnes, Allan J AU - Brunet, Bertrand R AU - Choo, Robin E AU - Mura, Patrick AU - Johnson, Rolley E AU - Jones, Hendrée E AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 497 EP - 503 VL - 32 IS - 4 KW - Analgesics, Opioid KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Young Adult KW - Opioid-Related Disorders -- metabolism KW - Reproducibility of Results KW - Dose-Response Relationship, Drug KW - Humans KW - Cost-Benefit Analysis KW - Drug Monitoring KW - Adult KW - Specimen Handling KW - Gas Chromatography-Mass Spectrometry KW - Opioid-Related Disorders -- rehabilitation KW - Female KW - Pregnancy -- metabolism KW - Sweat -- metabolism KW - Analgesics, Opioid -- metabolism KW - Methadone -- pharmacokinetics KW - Analgesics, Opioid -- pharmacokinetics KW - Methadone -- metabolism KW - Methadone -- administration & dosage KW - Analgesics, Opioid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/749026111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Therapeutic+drug+monitoring&rft.atitle=Excretion+of+methadone+in+sweat+of+pregnant+women+throughout+gestation+after+controlled+methadone+administration.&rft.au=Barnes%2C+Allan+J%3BBrunet%2C+Bertrand+R%3BChoo%2C+Robin+E%3BMura%2C+Patrick%3BJohnson%2C+Rolley+E%3BJones%2C+Hendr%C3%A9e+E%3BHuestis%2C+Marilyn+A&rft.aulast=Barnes&rft.aufirst=Allan&rft.date=2010-08-01&rft.volume=32&rft.issue=4&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=Therapeutic+drug+monitoring&rft.issn=1536-3694&rft_id=info:doi/10.1097%2FFTD.0b013e3181e44293 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-05 N1 - Date created - 2010-07-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Chem Lab Med. 2004;42(11):1273-87 [15576290] J Anal Toxicol. 1999 Sep;23(5):313-22 [10488917] Clin Dermatol. 2006 Mar-Apr;24(2):80-3 [16487877] Clin Chem. 2006 Aug;52(8):1539-45 [16740647] J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 1;852(1-2):333-7 [17301004] J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 1;852(1-2):450-8 [17369000] Clin Chem. 2008 Jan;54(1):172-80 [17981924] Forensic Sci Int. 2008 Jan 30;174(2-3):107-10 [17428631] Ther Drug Monit. 2008 Aug;30(4):536-9 [18641544] Anal Bioanal Chem. 2008 Sep;392(1-2):115-27 [18607576] Am J Addict. 2008 Sep-Oct;17(5):372-86 [18770079] Clin Chem. 2009 Mar;55(3):454-62 [19168553] Clin Chem. 2009 Nov;55(11):1910-31 [19745062] Ther Drug Monit. 2010 Feb;32(1):40-9 [19927046] J Anal Toxicol. 2000 Oct;24(7):509-21 [11043653] Addiction. 2004 Feb;99(2):259 [14756718] J Anal Toxicol. 2004 May-Jun;28(4):253-9 [15189676] Clin Chem. 2004 Nov;50(11):2083-90 [15271860] Am J Obstet Gynecol. 1969 Dec 1;105(7):997-1003 [5352597] Res Commun Chem Pathol Pharmacol. 1973 Jan;5(1):1-8 [4686102] J Pediatr. 1973 Dec;83(6):1055-61 [4757521] Am J Obstet Gynecol. 1976 May 15;125(2):135-42 [1266895] Clin Chem. 1984 Feb;30(2):290-2 [6692538] Semin Perinatol. 1991 Aug;15(4):331-9 [1948145] J Anal Toxicol. 1994 Oct;18(6):298-305 [7823536] Ther Drug Monit. 1996 Aug;18(4):450-5 [8857567] J Anal Toxicol. 1996 Oct;20(6):393-7 [8889674] J Forensic Sci. 1996 Nov;41(6):933-7 [8914283] Ther Drug Monit. 1998 Feb;20(1):35-40 [9485552] Int J Legal Med. 1998;111(2):82-4 [9541855] Clin Chem. 2005 Nov;51(11):2085-94 [16166169] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/FTD.0b013e3181e44293 ER - TY - JOUR T1 - Phase II trial of pazopanib (GW786034), an oral multi-targeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02). AN - 749019533; 20200024 AB - The objective of this phase II single-arm study was to evaluate the efficacy and safety of pazopanib, a multi-targeted tyrosine kinase inhibitor, against vascular endothelial growth factor receptor (VEGFR)-1, -2, and -3, platelet-derived growth factor receptor-alpha and -beta, and c-Kit, in recurrent glioblastoma. Patients with or =6 months (PFS6 = 3%). Thirty patients (86%) had died and median survival was 35 weeks (95% CI: 24-47 weeks). Pazopanib was reasonably well tolerated with a spectrum of toxicities similar to other anti-VEGF/VEGFR agents. Single-agent pazopanib did not prolong PFS in this patient population but showed in situ biological activity as demonstrated by radiographic responses. ClinicalTrials.gov identifier: NCT00459381. JF - Neuro-oncology AU - Iwamoto, Fabio M AU - Lamborn, Kathleen R AU - Robins, H Ian AU - Mehta, Minesh P AU - Chang, Susan M AU - Butowski, Nicholas A AU - Deangelis, Lisa M AU - Abrey, Lauren E AU - Zhang, Wei-Ting AU - Prados, Michael D AU - Fine, Howard A AD - Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 855 EP - 861 VL - 12 IS - 8 KW - Angiogenesis Inhibitors KW - 0 KW - Pyrimidines KW - Sulfonamides KW - pazopanib KW - 7RN5DR86CK KW - Index Medicus KW - Magnetic Resonance Imaging KW - Administration, Oral KW - Neovascularization, Pathologic -- drug therapy KW - Humans KW - Adult KW - Treatment Outcome KW - Disease Progression KW - Aged KW - Middle Aged KW - Male KW - Female KW - Pyrimidines -- adverse effects KW - Brain Neoplasms -- pathology KW - Brain Neoplasms -- mortality KW - Glioblastoma -- mortality KW - Brain Neoplasms -- blood supply KW - Glioblastoma -- drug therapy KW - Sulfonamides -- administration & dosage KW - Pyrimidines -- administration & dosage KW - Angiogenesis Inhibitors -- administration & dosage KW - Sulfonamides -- adverse effects KW - Brain Neoplasms -- drug therapy KW - Glioblastoma -- blood supply KW - Neoplasm Recurrence, Local -- drug therapy KW - Glioblastoma -- pathology KW - Angiogenesis Inhibitors -- adverse effects KW - Neoplasm Recurrence, Local -- pathology KW - Neoplasm Recurrence, Local -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/749019533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuro-oncology&rft.atitle=Phase+II+trial+of+pazopanib+%28GW786034%29%2C+an+oral+multi-targeted+angiogenesis+inhibitor%2C+for+adults+with+recurrent+glioblastoma+%28North+American+Brain+Tumor+Consortium+Study+06-02%29.&rft.au=Iwamoto%2C+Fabio+M%3BLamborn%2C+Kathleen+R%3BRobins%2C+H+Ian%3BMehta%2C+Minesh+P%3BChang%2C+Susan+M%3BButowski%2C+Nicholas+A%3BDeangelis%2C+Lisa+M%3BAbrey%2C+Lauren+E%3BZhang%2C+Wei-Ting%3BPrados%2C+Michael+D%3BFine%2C+Howard+A&rft.aulast=Iwamoto&rft.aufirst=Fabio&rft.date=2010-08-01&rft.volume=12&rft.issue=8&rft.spage=855&rft.isbn=&rft.btitle=&rft.title=Neuro-oncology&rft.issn=1523-5866&rft_id=info:doi/10.1093%2Fneuonc%2Fnoq025 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-12 N1 - Date created - 2010-07-30 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00459381; ClinicalTrials.gov N1 - SuppNotes - Cited By: J Clin Oncol. 1999 Aug;17(8):2572-8 [10561324] J Clin Oncol. 2009 Oct 1;27(28):4733-40 [19720927] Am J Pathol. 2003 Apr;162(4):1083-93 [12651601] Clin Cancer Res. 2003 Apr;9(4):1399-405 [12684411] J Clin Invest. 2003 May;111(9):1287-95 [12727920] J Neurosurg. 1977 Sep;47(3):329-35 [894339] Proc Natl Acad Sci U S A. 1988 Oct;85(20):7748-52 [2845420] J Clin Oncol. 1990 Jul;8(7):1277-80 [2358840] Cancer Res. 1992 Jun 1;52(11):3213-9 [1317261] Nature. 1992 Oct 29;359(6398):845-8 [1279432] Science. 1998 Jan 23;279(5350):577-80 [9438854] Science. 2005 Jan 7;307(5706):58-62 [15637262] N Engl J Med. 2005 Mar 10;352(10):987-96 [15758009] Cancer Res. 2005 Jul 1;65(13):5523-34 [15994924] Cancer Cell. 2006 Apr;9(4):287-300 [16616334] Cancer Cell. 2006 May;9(5):391-403 [16697959] Clin Cancer Res. 2006 Aug 15;12(16):4899-907 [16914578] N Engl J Med. 2007 Jan 11;356(2):115-24 [17215529] Cancer Cell. 2007 Jan;11(1):83-95 [17222792] Cell Oncol. 2007;29(5):399-408 [17726262] Neuro Oncol. 2008 Apr;10(2):162-70 [18356283] N Engl J Med. 2008 Jul 31;359(5):492-507 [18669428] J Clin Oncol. 2008 Oct 1;26(28):4659-65 [18824712] Curr Opin Investig Drugs. 2008 Dec;9(12):1324-35 [19037839] J Clin Oncol. 2009 Feb 10;27(5):740-5 [19114704] Cancer Cell. 2009 Mar 3;15(3):220-31 [19249680] PLoS One. 2009;4(4):e5123 [19352490] J Clin Oncol. 2009 May 20;27(15):2542-52 [19332720] J Clin Oncol. 2009 Jul 1;27(19):3126-32 [19451427] Int J Radiat Oncol Biol Phys. 2009 Sep 1;75(1):156-63 [19167838] Neoplasia. 2000 Jul-Aug;2(4):306-14 [11005565] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/neuonc/noq025 ER - TY - JOUR T1 - Mechanisms of MDMA (ecstasy)-induced oxidative stress, mitochondrial dysfunction, and organ damage. AN - 748930143; 20420575 AB - Despite numerous reports about the acute and sub-chronic toxicities caused by MDMA (3,4-methylenedioxymethamphetamine, ecstasy), the underlying mechanism of organ damage is poorly understood. The aim of this review is to present an update of the mechanistic studies on MDMA-mediated organ damage partly caused by increased oxidative/nitrosative stress. Because of the extensive reviews on MDMA-mediated oxidative stress and tissue damage, we specifically focus on the mechanisms and consequences of oxidative-modifications of mitochondrial proteins, leading to mitochondrial dysfunction. We briefly describe a method to systematically identify oxidatively-modified mitochondrial proteins in control and MDMA-exposed rats by using biotin-N-maleimide (biotin-NM) as a sensitive probe for oxidized proteins. We also describe various applications and advantages of this Cys-targeted proteomics method and alternative approaches to overcome potential limitations of this method in studying oxidized proteins from MDMA-exposed tissues. Finally we discuss the mechanism of synergistic drug-interaction between MDMA and other abused substances including alcohol (ethanol) as well as application of this redox-based proteomics method in translational studies for developing effective preventive and therapeutic agents against MDMA-induced organ damage. JF - Current pharmaceutical biotechnology AU - Song, Byoung-Joon AU - Moon, Kwan-Hoon AU - Upreti, Vijay V AU - Eddington, Natalie D AU - Lee, Insong J AD - Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, 9000 Rockville Pike, Bethesda, MD 20892, USA. bj.song@nih.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 434 EP - 443 VL - 11 IS - 5 KW - Hallucinogens KW - 0 KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Rats KW - Animals KW - Humans KW - Hallucinogens -- toxicity KW - Mitochondria -- drug effects KW - Oxidative Stress -- drug effects KW - N-Methyl-3,4-methylenedioxyamphetamine -- toxicity KW - Multiple Organ Failure -- physiopathology KW - Multiple Organ Failure -- chemically induced KW - Viscera -- drug effects KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748930143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+pharmaceutical+biotechnology&rft.atitle=Mechanisms+of+MDMA+%28ecstasy%29-induced+oxidative+stress%2C+mitochondrial+dysfunction%2C+and+organ+damage.&rft.au=Song%2C+Byoung-Joon%3BMoon%2C+Kwan-Hoon%3BUpreti%2C+Vijay+V%3BEddington%2C+Natalie+D%3BLee%2C+Insong+J&rft.aulast=Song&rft.aufirst=Byoung-Joon&rft.date=2010-08-01&rft.volume=11&rft.issue=5&rft.spage=434&rft.isbn=&rft.btitle=&rft.title=Current+pharmaceutical+biotechnology&rft.issn=1873-4316&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-15 N1 - Date created - 2010-07-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Physiol Lung Cell Mol Physiol. 2004 Aug;287(2):L262-8 [15246980] Eur J Pharmacol. 2004 Oct 1;500(1-3):3-13 [15464016] EMBO J. 1987 May;6(5):1361-6 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[18778711] Free Radic Biol Med. 1999 Jan;26(1-2):3-13 [9890635] J Pharmacol Exp Ther. 1999 Jul;290(1):136-45 [10381769] Neuroscience. 1999;91(4):1379-87 [10391444] Drug Alcohol Depend. 1999 Jun 1;55(1-2):105-15 [10402155] J Biol Chem. 1999 Oct 15;274(42):29726-32 [10514446] Arch Intern Med. 1999 Oct 11;159(18):2221-4 [10527300] Proteomics. 2004 Nov;4(11):3401-12 [15449375] J Pharmacol Exp Ther. 2005 Feb;312(2):694-701 [15456837] Clin J Am Soc Nephrol. 2008 Nov;3(6):1852-60 [18684895] J Neuroimmune Pharmacol. 2008 Dec;3(4):203-17 [18709468] Free Radic Biol Med. 2008 Dec 1;45(11):1542-50 [18845238] Toxicology. 2008 Dec 5;254(1-2):42-50 [18848861] Chem Phys Lipids. 2009 Jan;157(1):1-11 [18977338] Neuroscience. 2009 Jan 23;158(2):514-23 [19015003] Mol Neurobiol. 2009 Jun;39(3):210-71 [19373443] Toxicol Lett. 2009 Jul 24;188(2):167-72 [19446252] Free Radic Biol Med. 1992 Oct;13(4):391-405 [1398218] J Pharmacol Exp Ther. 1995 May;273(2):667-73 [7538579] FEBS Lett. 1996 Apr 29;385(1-2):63-6 [8641468] Gut. 1996 Mar;38(3):454-8 [8675102] Eur J Pharmacol. 1997 Apr 4;323(2-3):173-80 [9128836] J Biol Chem. 1997 Aug 15;272(33):20313-6 [9252331] Electrophoresis. 1997 Oct;18(11):2071-7 [9420172] Immunopharmacology. 1998 Jan;38(3):253-60 [9506825] Annu Rev Pharmacol Toxicol. 1998;38:229-55 [9597155] Brain Res. 1998 Jun 8;795(1-2):257-63 [9622646] Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7659-63 [9636206] J Hepatol. 1998 Sep;29(3):394-7 [9764985] Int J Neuropsychopharmacol. 2009 Jul;12(6):749-59 [19046482] Free Radic Biol Med. 2009 Sep 15;47(6):767-78 [19539749] Am J Addict. 2009 Nov-Dec;18(6):452-61 [19874166] Toxicol Lett. 2009 Dec 1;191(1):40-6 [19683041] Addict Biol. 2010 Jan;15(1):96-9 [19878142] Free Radic Biol Med. 2010 Feb 1;48(3):391-8 [19922789] Forensic Sci Int. 1999 Sep 30;104(1):65-74 [10533279] J Neurosci. 1999 Dec 1;19(23):10289-94 [10575026] Liver. 2000 Feb;20(1):8-15 [10726956] Chem Res Toxicol. 2000 Mar;13(3):135-60 [10725110] Anal Biochem. 2000 Aug 1;283(2):214-21 [10906242] Mol Pharmacol. 2000 Sep;58(3):535-41 [10953046] Intensive Care Med. 2001 May;27(5):803-11 [11430535] Chem Res Toxicol. 2001 Jul;14(7):863-70 [11453733] Drug Alcohol Depend. 2001 Sep 1;64(1):9-17 [11470336] Chem Res Toxicol. 2001 Sep;14(9):1184-92 [11559032] Proteomics. 2001 Mar;1(3):377-96 [11680884] Int J Cancer. 2002 Jan 10;97(2):261-5 [11774273] Arch Toxicol. 2002 Oct;76(10):581-8 [12373454] Biochim Biophys Acta. 2002 Oct 9;1588(1):26-32 [12379310] Electrophoresis. 2002 Dec;23(24):4142-56 [12481271] J Psychoactive Drugs. 2002 Apr-Jun;34(2):163-9 [12691206] Free Radic Res. 2003 May;37(5):491-7 [12797468] J Subst Abuse Treat. 2003 Apr;24(3):209-15 [12810141] J Biol Chem. 2003 Sep 26;278(39):37497-510 [12840032] J Biol Chem. 2003 Sep 26;278(39):37223-30 [12857734] Antioxid Redox Signal. 2003 Oct;5(5):577-82 [14580313] Ann Emerg Med. 2003 Dec;42(6):759-62 [14634599] J Biol Chem. 2004 Jan 23;279(4):2535-43 [14597634] Biochem Pharmacol. 2004 Mar 15;67(6):1025-33 [15006539] Am J Physiol Gastrointest Liver Physiol. 2004 Apr;286(4):G521-7 [14670822] Mol Cell Proteomics. 2004 Mar;3(3):273-8 [14726493] Protein Expr Purif. 2004 Jun;35(2):320-6 [15135409] Chem Res Toxicol. 2004 May;17(5):623-32 [15144219] Toxicology. 2004 Aug 5;200(2-3):193-203 [15212815] Ther Drug Monit. 2004 Apr;26(2):137-44 [15228154] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Structural Model of the Pre-pore Ring-like Structure of Panton-Valentine Leukocidin: Providing Dimensionality to Biophysical and Mutational Data AN - 744698692; 13134388 AB - Panton-Valentine leukocidin (PVL) is a bipartite toxin that plays an important role in the pathogenesis of methicillin-resistant Staphylococcus aureus. Recent clinical data suggest a correlation between PVL and severe cases of S. aureus pneumonia. A clear understanding of the structure and function of PVL is critical to the development of novel, effective treatments. Here, we report an all-atom model of the macromolecular structure of Panton-Valentine leukocidin in its octameric, pre-pore conformation that confirms and extends our understanding of the toxin's mechanism of action. JF - Journal of Biomolecular Structure and Dynamics AU - Aman, MJ AU - Karauzum, H AU - Bowden, M G AU - Nguyen, T L AD - Target Structure-Based Drug Discovery Group, SAIC Frederick, Inc., National Cancer Institute-Frederick, MD 21702, USA, nguyent5@mail.nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1 EP - 12 VL - 28 IS - 1 SN - 0739-1102, 0739-1102 KW - Microbiology Abstracts B: Bacteriology KW - Macromolecules KW - Data processing KW - leukocidin KW - Structure-function relationships KW - Drug resistance KW - Staphylococcus aureus KW - Toxins KW - Pneumonia KW - Models KW - Conformation KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744698692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+Structure+and+Dynamics&rft.atitle=Structural+Model+of+the+Pre-pore+Ring-like+Structure+of+Panton-Valentine+Leukocidin%3A+Providing+Dimensionality+to+Biophysical+and+Mutational+Data&rft.au=Aman%2C+MJ%3BKarauzum%2C+H%3BBowden%2C+M+G%3BNguyen%2C+T+L&rft.aulast=Aman&rft.aufirst=MJ&rft.date=2010-08-01&rft.volume=28&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+Structure+and+Dynamics&rft.issn=07391102&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Macromolecules; Data processing; leukocidin; Structure-function relationships; Drug resistance; Pneumonia; Toxins; Conformation; Models; Staphylococcus aureus ER - TY - JOUR T1 - Cytotoxicity of the anti-CD22 immunotoxin HA22 (CAT-8015) against paediatric acute lymphoblastic leukaemia. AN - 734009335; 20528877 AB - Acute lymphoblastic leukaemia (ALL) remains the most frequent cause of cancer-related mortality in paediatrics and outcome is poor for patients who have high-risk ALL or relapse. HA22 (CAT-8015) is an immunotoxin composed of an anti-CD22 variable fragment linked to a 38 kDa truncated protein derived from Pseudomonas exotoxin A. Using a bone marrow mesenchymal cell culture assay to support ALL cell viability, we investigated the in vitro cytotoxicity of HA22 against ALL blasts from newly diagnosed (n = 13) and relapsed patients (n = 22). There was interpatient variability in sensitivity to HA22. Twenty-four of 35 patient samples tested were sensitive (median 50% lethal concentration 3 ng/ml, range 1-80 ng/ml). Blasts from the other 11 patients were not killed by 500 ng/ml HA22. The median 50% lethal concentration was 20 ng/ml for all patients. There was no significant difference in HA22 sensitivity between diagnosis and relapse samples but peripheral blood ALL blasts were more sensitive to HA22 than those from bone marrow (P = 0.008). Thus, HA22, at concentrations achievable in patients, is highly cytotoxic to B-lineage ALL cells. These results provide a strong rationale for clinical testing of this agent in children with drug-resistant ALL and offers the potential to reduce morbidities of treatment while improving outcome. JF - British journal of haematology AU - Mussai, Francis AU - Campana, Dario AU - Bhojwani, Deepa AU - Stetler-Stevenson, Maryalice AU - Steinberg, Seth M AU - Wayne, Alan S AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA. Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 352 EP - 358 VL - 150 IS - 3 KW - Antineoplastic Agents KW - 0 KW - Antineoplastic Agents, Hormonal KW - Bacterial Toxins KW - Exotoxins KW - Sialic Acid Binding Ig-like Lectin 2 KW - immunotoxin HA22 KW - Dexamethasone KW - 7S5I7G3JQL KW - Index Medicus KW - Young Adult KW - Dose-Response Relationship, Drug KW - Dexamethasone -- pharmacology KW - Humans KW - Antineoplastic Agents, Hormonal -- pharmacology KW - Child KW - Cell Death -- drug effects KW - Child, Preschool KW - Infant KW - Tumor Cells, Cultured KW - Lethal Dose 50 KW - Adolescent KW - Drug Evaluation, Preclinical KW - Male KW - Female KW - Exotoxins -- pharmacology KW - Sialic Acid Binding Ig-like Lectin 2 -- immunology KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- pathology KW - Bacterial Toxins -- pharmacology KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734009335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+haematology&rft.atitle=Cytotoxicity+of+the+anti-CD22+immunotoxin+HA22+%28CAT-8015%29+against+paediatric+acute+lymphoblastic+leukaemia.&rft.au=Mussai%2C+Francis%3BCampana%2C+Dario%3BBhojwani%2C+Deepa%3BStetler-Stevenson%2C+Maryalice%3BSteinberg%2C+Seth+M%3BWayne%2C+Alan+S%3BPastan%2C+Ira&rft.aulast=Mussai&rft.aufirst=Francis&rft.date=2010-08-01&rft.volume=150&rft.issue=3&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=British+journal+of+haematology&rft.issn=1365-2141&rft_id=info:doi/10.1111%2Fj.1365-2141.2010.08251.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-01 N1 - Date created - 2010-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2141.2010.08251.x ER - TY - JOUR T1 - Speriolin is a novel human and mouse sperm centrosome protein. AN - 734000428; 20542897 AB - Oocytes in humans, mice and other mammals lack identifiable centrioles. The proximal centriole brought in by the fertilizing sperm in humans and most other mammals appears to gives rise to the centrioles at the spindle poles in the zygote, and is believed to indicate that centrioles are inherited through the paternal lineage. However, both the proximal and distal sperm centrioles degenerate in mice and other rodents. A bipolar mitotic spindle nucleates from multiple centrosome-like structures in the mouse zygote and centrioles are not seen until the blastocyst stage, suggesting that centrioles are inherited through the maternal lineage in mice. We previously identified speriolin as a spermatogenic cell-specific binding partner of Cdc20 that co-localizes with pericentrin in mouse spermatocytes and is present in the centrosome in round spermatids. The nature and localization of speriolin in mouse and human sperm and the fate of speriolin following fertilization in the mouse were determined using immunofluorescence microscopy, immunoelectron microscopy and western blotting. Speriolin surrounds the intact proximal centriole in human sperm, but is localized at the periphery of the disordered distal centriole in mouse sperm. Human speriolin contains an internal 163-amino acid region not present in mouse that may contribute to localization differences. Speriolin is carried into the mouse oocyte during fertilization and remains associated with the decondensing sperm head in zygotes. The speriolin spot appears to undergo duplication or splitting during the first interphase and is detectable in 2-cell embryos. Speriolin is a novel centrosomal protein present in the connecting piece region of mouse and human sperm that is transmitted to the mouse zygote and can be detected throughout the first mitotic division. JF - Human reproduction (Oxford, England) AU - Goto, M AU - O'Brien, D A AU - Eddy, E M AD - Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, 111 T.W. Alexander Drive, NC 27709, USA. Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 1884 EP - 1894 VL - 25 IS - 8 KW - Carrier Proteins KW - 0 KW - Cell Cycle Proteins KW - Spatc1 protein, mouse KW - speriolin protein, human KW - Index Medicus KW - Sequence Analysis, Protein KW - Animals KW - Solubility KW - Conserved Sequence KW - Humans KW - Mice KW - Amino Acid Sequence KW - Zygote -- metabolism KW - Male KW - Cell Cycle Proteins -- physiology KW - Cell Cycle Proteins -- chemistry KW - Cell Cycle Proteins -- analysis KW - Carrier Proteins -- chemistry KW - Spermatozoa -- metabolism KW - Carrier Proteins -- physiology KW - Carrier Proteins -- analysis KW - Centrosome -- metabolism KW - Spermatozoa -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734000428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+reproduction+%28Oxford%2C+England%29&rft.atitle=Speriolin+is+a+novel+human+and+mouse+sperm+centrosome+protein.&rft.au=Goto%2C+M%3BO%27Brien%2C+D+A%3BEddy%2C+E+M&rft.aulast=Goto&rft.aufirst=M&rft.date=2010-08-01&rft.volume=25&rft.issue=8&rft.spage=1884&rft.isbn=&rft.btitle=&rft.title=Human+reproduction+%28Oxford%2C+England%29&rft.issn=1460-2350&rft_id=info:doi/10.1093%2Fhumrep%2Fdeq138 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-23 N1 - Date created - 2010-07-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Fertil Steril. 2009 Sep;92(3):835-48 [19631936] Cell. 2009 Nov 13;139(4):663-78 [19914163] Cell Motil Cytoskeleton. 1999;43(2):137-44 [10379838] Mol Biol Cell. 1999 Sep;10(9):2955-69 [10473639] Genomics. 1999 Sep 1;60(2):111-20 [10486202] J Ultrastruct Res. 1965 Feb;12:160-86 [14289426] Dev Biol. 2010 Mar 15;339(2):439-50 [20079731] Reproduction. 2006 Sep;132(3):423-34 [16940283] J Cell Sci. 1972 Mar;10(2):369-85 [5018030] J Cell Sci. 1972 Sep;11(2):521-41 [5076360] Anat Rec. 1973 Oct;177(2):289-301 [4356969] Dev Biol. 1975 Jun;44(2):394-436 [805734] Cell. 1983 Dec;35(3 Pt 2):621-9 [6652679] Hum Reprod. 1988 Nov;3(8):968-77 [3204152] Gamete Res. 1988 Sep;21(1):41-50 [3229722] Dev Biol. 1989 May;133(1):24-36 [2651182] Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6785-9 [1862101] Biol Cell. 1991;72(1-2):61-6 [1756312] J Cell Sci. 1993 Feb;104 ( Pt 2):383-9 [8505367] J Cell Sci. 1993 May;105 ( Pt 1):157-66 [8360270] Dev Biol. 1994 Oct;165(2):299-335 [7958403] Hum Reprod. 1996 Feb;11(2):345-56 [8671223] Arch Androl. 1997 Jan-Feb;38(1):37-48 [9017121] Hum Reprod. 1999 Nov;14(11):2791-5 [10548624] Hum Reprod. 2000 Feb;15(2):256-63 [10655294] Biol Reprod. 2000 May;62(5):1184-92 [10775165] Microsc Res Tech. 2000 Jun 1;49(5):435-44 [10842370] Microsc Res Tech. 2000 Jun 1;49(5):445-50 [10842371] Mol Reprod Dev. 2000 Aug;56(4):502-11 [10911400] Mol Cell Endocrinol. 2000 Aug 15;166(1):59-62 [10989209] J Androl. 2000 Nov-Dec;21(6):799-808 [11105905] Mol Biol Cell. 2001 Jun;12(6):1687-97 [11408577] Biol Reprod Suppl. 1970;2:90-127 [12254595] Mol Cell. 2002 May;9(5):931-43 [12049731] Hum Reprod. 2002 Sep;17(9):2344-9 [12202423] Nat Cell Biol. 2002 Oct;4 Suppl:s41-9 [12479614] Nature. 2003 Dec 4;426(6966):570-4 [14654843] Nature. 2004 Jul 15;430(6997):360-4 [15254539] J Biol Chem. 2004 Oct 1;279(40):42128-38 [15280373] Z Zellforsch Mikrosk Anat. 1965 Jul 30;67(3):279-96 [5894161] Anat Rec. 1971 Feb;169(2):155-72 [5544616] Biol Reprod. 1970 Jun;2:Suppl 2:44-63 [4106842] Biol Reprod. 1997 Nov;57(5):967-75 [9369159] Rev Reprod. 1997 Jan;2(1):19-27 [9414462] Dev Biol. 1998 Jul 15;199(2):250-60 [9698445] Dev Biol. 1998 Nov 15;203(2):424-34 [9808791] Mol Hum Reprod. 1998 Dec;4(12):1122-9 [9872362] Am J Anat. 1965 May;116:567-609 [14324688] Biol Reprod. 2005 Jan;72(1):2-13 [15385423] Nat Rev Genet. 2005 Mar;6(3):194-205 [15738963] Trends Cell Biol. 2005 Jun;15(6):303-11 [15953548] Fertil Steril. 2005 Oct;84 Suppl 2:1241-8 [16210017] Adv Exp Med Biol. 2007;591:58-71 [17176554] J Cell Sci. 2007 Jan 1;120(Pt 1):7-15 [17182899] Nat Rev Mol Cell Biol. 2007 Jun;8(6):451-63 [17505520] Cytogenet Genome Res. 2007;119(1-2):68-73 [18160784] Nat Genet. 2008 Feb;40(2):232-6 [18157127] Science. 2008 Feb 8;319(5864):816-9 [18174396] Eur J Cell Biol. 2008 Mar;87(3):137-46 [18171590] Dev Biol. 2008 Jul 15;319(2):201-10 [18495105] Cell. 2009 Jan 9;136(1):188-188.e1 [19135899] Mol Reprod Dev. 2009 Mar;76(3):270-7 [18646048] Mol Cells. 2009 Feb 28;27(2):135-42 [19277494] Fertil Steril. 2009 Apr;91(4):1271-2 [18706544] Mol Cell Endocrinol. 2009 Jul 10;306(1-2):24-32 [19481682] Mol Hum Reprod. 2009 Sep;15(9):531-8 [19549764] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/humrep/deq138 ER - TY - JOUR T1 - 5A apolipoprotein mimetic peptide promotes cholesterol efflux and reduces atherosclerosis in mice. AN - 733990436; 20484557 AB - Intravenous administration of apolipoprotein (apo) A-I complexed with phospholipid has been shown to rapidly reduce plaque size in both animal models and humans. Short synthetic amphipathic peptides can mimic the antiatherogenic properties of apoA-I and have been proposed as alternative therapeutic agents. In this study, we investigated the atheroprotective effect of the 5A peptide, a bihelical amphipathic peptide that specifically effluxes cholesterol from cells by ATP-binding cassette transporter 1 (ABCA1). 5A stimulated a 3.5-fold increase in ABCA1-mediated efflux from cells and an additional 2.5-fold increase after complexing it with phospholipid (1:7 mol/mol). 5A-palmitoyl oleoyl phosphatidyl choline (POPC), but not free 5A, was also found to promote cholesterol efflux by ABCG1. When incubated with human serum, 5A-POPC bound primarily to high-density lipoprotein (HDL) but also to low-density lipoprotein (LDL) and promoted the transfer of cholesterol from LDL to HDL. Twenty-four hours after intravenous injection of 5A-POPC (30 mg/kg) into apoE-knockout (KO) mice, both the cholesterol (181%) and phospholipid (219%) content of HDL significantly increased. By an in vivo cholesterol isotope dilution study and monitoring of the flux of cholesterol from radiolabeled macrophages to stool, 5A-POPC treatment was observed to increase reverse cholesterol transport. In three separate studies, 5A when complexed with various phospholipids reduced aortic plaque surface area by 29 to 53% (n = 8 per group; p < 0.02) in apoE-KO mice. No signs of toxicity from the treatment were observed during these studies. In summary, 5A promotes cholesterol efflux both in vitro and in vivo and reduces atherosclerosis in apoE-KO mice, indicating that it may be a useful alternative to apoA-I for HDL therapy. JF - The Journal of pharmacology and experimental therapeutics AU - Amar, Marcelo J A AU - D'Souza, Wilissa AU - Turner, Scott AU - Demosky, Stephen AU - Sviridov, Denis AU - Stonik, John AU - Luchoomun, Jayraz AU - Voogt, Jason AU - Hellerstein, Marc AU - Sviridov, Dmitri AU - Remaley, Alan T AD - Lipoprotein Metabolism Section, Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. ma90x@nih.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 634 EP - 641 VL - 334 IS - 2 KW - ABCG1 protein, mouse KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 1 KW - Apolipoprotein A-I KW - Apolipoproteins E KW - Lipoproteins KW - Lipoproteins, HDL KW - Lipoproteins, LDL KW - Peptides KW - Phosphatidylcholines KW - Cholesterol KW - 97C5T2UQ7J KW - Index Medicus KW - Animals KW - Lipoproteins -- metabolism KW - ATP-Binding Cassette Transporters -- metabolism KW - Humans KW - Lipoproteins, HDL -- blood KW - Aorta -- pathology KW - Biological Transport KW - Mice KW - Macrophages, Peritoneal -- drug effects KW - Mice, Knockout KW - Rats KW - Lipoproteins, LDL -- blood KW - Rats, Sprague-Dawley KW - Aorta -- drug effects KW - Phosphatidylcholines -- chemistry KW - Macrophages, Peritoneal -- metabolism KW - In Vitro Techniques KW - Mice, Inbred C57BL KW - Molecular Mimicry KW - Male KW - Female KW - Apolipoproteins E -- genetics KW - Atherosclerosis -- drug therapy KW - Atherosclerosis -- pathology KW - Cholesterol -- metabolism KW - Peptides -- chemistry KW - Atherosclerosis -- metabolism KW - Apolipoprotein A-I -- physiology KW - Apolipoprotein A-I -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733990436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=5A+apolipoprotein+mimetic+peptide+promotes+cholesterol+efflux+and+reduces+atherosclerosis+in+mice.&rft.au=Amar%2C+Marcelo+J+A%3BD%27Souza%2C+Wilissa%3BTurner%2C+Scott%3BDemosky%2C+Stephen%3BSviridov%2C+Denis%3BStonik%2C+John%3BLuchoomun%2C+Jayraz%3BVoogt%2C+Jason%3BHellerstein%2C+Marc%3BSviridov%2C+Dmitri%3BRemaley%2C+Alan+T&rft.aulast=Amar&rft.aufirst=Marcelo+J&rft.date=2010-08-01&rft.volume=334&rft.issue=2&rft.spage=634&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.110.167890 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-17 N1 - Date created - 2010-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2007 Apr 18;297(15):1675-82 [17387133] Biochemistry. 2007 Aug 21;46(33):9388-98 [17655203] Curr Opin Investig Drugs. 2008 Mar;9(3):274-80 [18311663] J Lipid Res. 2008 May;49(5):1006-14 [18252847] J Lipid Res. 2008 Jun;49(6):1344-52 [18323573] J Am Coll Cardiol. 2008 Jun 10;51(23):2199-211 [18534265] Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12176-81 [18719128] J Lipid Res. 2008 Nov;49(11):2302-11 [18621920] J Lipid Res. 2008 Nov;49(11):2312-22 [18622028] Expert Rev Cardiovasc Ther. 2008 Oct;6(9):1203-15 [18939908] Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):2071-7 [18617650] J Biol Chem. 2008 Nov 21;283(47):32273-82 [18805791] J Lipid Res. 2009 Feb;50(2):275-84 [18827283] Am J Cardiol. 2009 Nov 16;104(10 Suppl):10E-5E [19895939] J Lipid Res. 2009 Sep;50(9):1889-900 [19433476] Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):139-43 [19797709] Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):246-52 [19965776] Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):283-9 [19965777] J Lipid Res. 2010 Jun;51(6):1496-503 [20075422] J Lipid Res. 2000 Aug;41(8):1261-7 [10946014] Biochem Biophys Res Commun. 2001 Jan 26;280(3):818-23 [11162594] J Biol Chem. 2001 May 11;276(19):15641-9 [11278646] Atherosclerosis. 2002 Nov;165(1):15-22 [12208466] J Lipid Res. 2003 Apr;44(4):828-36 [12562845] JAMA. 2003 Nov 5;290(17):2292-300 [14600188] Circulation. 2004 Jun 29;109(25):3215-20 [15197147] Methods Enzymol. 1986;128:553-82 [3724523] J Lipid Res. 1993 Oct;34(10):1825-31 [8245729] J Biol Chem. 1994 Sep 16;269(37):22975-82 [8083197] Arterioscler Thromb Vasc Biol. 1996 Sep;16(9):1203-14 [8792776] J Lipid Res. 1998 Dec;39(12):2436-42 [9831632] J Biol Chem. 1957 May;226(1):497-509 [13428781] Am J Cardiol. 2005 Sep 5;96(5A):61F-68F [16126025] Circulation. 2006 Feb 28;113(8):1140-50 [16505192] J Clin Invest. 2006 May;116(5):1435-42 [16670775] Biochim Biophys Acta. 2006 Jul;1761(7):655-66 [16798073] Curr Opin Investig Drugs. 2007 Mar;8(3):201-12 [17408115] Arterioscler Thromb Vasc Biol. 2003 May 1;23(5):712-9 [12615688] J Lipid Res. 2003 Jul;44(7):1373-80 [12700343] J Biol Chem. 2003 Oct 31;278(44):42976-84 [12928428] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.110.167890 ER - TY - JOUR T1 - Structural requirements for inverse agonism and neutral antagonism of indole-, benzimidazole-, and thienopyrrole-derived histamine H4 receptor ligands. AN - 733990269; 20484153 AB - The human histamine H(4) receptor (hH(4)R), coexpressed with Galpha(i2) and Gbeta(1)gamma(2) in Sf9 insect cells, is highly constitutively active, and thioperamide [THIO; N-cyclohexyl-4-(imidazol-4-yl)-1-piperidinecarbothioamide] is one of the most efficacious hH(4)R inverse agonists. High constitutive hH(4)R activity may have pathophysiological implications in which case inverse agonists may behave differently than neutral antagonists. To learn more about the structural requirements for hH(4)R inverse agonism, we investigated 25 compounds (indole, benzimidazole, and thienopyrrole derivatives) structurally related to the standard antagonist JNJ-7777120 [1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methyl-piperazine]. We characterized the compounds in radioligand binding assays by using [(3)H]histamine ([(3)H]HA) and in steady-state GTPase assays in the presence (antagonist mode) and absence (inverse agonist mode) of the agonist HA, yielding the following results: 1) Twenty-two compounds were inverse agonists (efficacy: 15-62% of the THIO effect), and only three compounds (12%) showed neutral antagonism. Thus, inverse agonism is far more common than neutral antagonism. 2) The inverse agonistic efficacy of the R5-monosubstituted indole-derived compounds increased with the volume of R5. R5 may interact with Trp(6.48) of the rotamer toggle switch and stabilize the inactive receptor conformation. 3) A subset of compounds showed large differences between the K(i) value from [(3)H]HA competition binding and the EC(50) value from steady-state GTPase assays, whereas the K(b) values were closer to the K(i) values. Thus, the two-state model should be extended to a model comprising a constitutively active hH(4)R state, which can be discriminated by inverse agonists from a structurally distinct HA-stabilized active state. JF - The Journal of pharmacology and experimental therapeutics AU - Schneider, Erich H AU - Strasser, Andrea AU - Thurmond, Robin L AU - Seifert, Roland AD - Departments of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany. schneidere@mail.nih.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 513 EP - 521 VL - 334 IS - 2 KW - Benzimidazoles KW - 0 KW - HRH4 protein, human KW - Histamine Agonists KW - Histamine Antagonists KW - Indoles KW - Ligands KW - Pyrroles KW - Receptors, G-Protein-Coupled KW - Receptors, Histamine KW - Thiophenes KW - Index Medicus KW - Drug Inverse Agonism KW - Animals KW - Humans KW - Binding, Competitive KW - Radioligand Assay KW - Drug Antagonism KW - Cell Line KW - Structure-Activity Relationship KW - Thiophenes -- chemistry KW - Histamine Antagonists -- pharmacology KW - Benzimidazoles -- pharmacology KW - Histamine Agonists -- pharmacology KW - Histamine Antagonists -- chemistry KW - Receptors, Histamine -- metabolism KW - Pyrroles -- chemistry KW - Pyrroles -- pharmacology KW - Histamine Agonists -- chemistry KW - Thiophenes -- pharmacology KW - Benzimidazoles -- chemistry KW - Receptors, G-Protein-Coupled -- metabolism KW - Indoles -- pharmacology KW - Indoles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733990269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Structural+requirements+for+inverse+agonism+and+neutral+antagonism+of+indole-%2C+benzimidazole-%2C+and+thienopyrrole-derived+histamine+H4+receptor+ligands.&rft.au=Schneider%2C+Erich+H%3BStrasser%2C+Andrea%3BThurmond%2C+Robin+L%3BSeifert%2C+Roland&rft.aulast=Schneider&rft.aufirst=Erich&rft.date=2010-08-01&rft.volume=334&rft.issue=2&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.110.165977 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-17 N1 - Date created - 2010-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.110.165977 ER - TY - JOUR T1 - Determination of the di-(2-ethylhexyl) phthalate NOAEL for reproductive development in the rat: importance of the retention of extra animals to adulthood. AN - 733989902; 20484383 AB - Deriving No Observed Adverse Effect Level (NOAEL) or benchmark dose is important for risk assessment and can be influenced by study design considerations. In order to define the di-(2-ethylhexyl) phthalate (DEHP) dose-response curve for reproductive malformations, we retained more offspring to adulthood to improve detection of these malformations in the reproductive assessment by continuous breeding study design. Sprague-Dawley rats were given a dietary administration of 1.5 (control), 10, 30, 100, 300, 1000, 7500, and 10,000 ppm DEHP. Male pups were evaluated for gross reproductive tract malformations (RTMs) associated with the "phthalate syndrome." DEHP treatment had minimal effects on P0 males. There was a statistically significant increase in F1 and F2 total RTMs (testis, epididymides, seminal vesicle, and prostate) in the 7500-ppm dose group and F1 10,000-ppm dose group. The 10,000-ppm exposed F1 males did not produce an F2 generation. The NOAEL for F1 and F2 RTM combined data, because in utero exposures were similar, were 100 ppm (4.8 mg/kg/day), which was close to the 5% response benchmark dose lower confidence limit of 142 ppm. The utility of evaluating more pups per litter was examined by generating power curves from a Monte Carlo simulation. These curves indicate a substantial increase in detection rate when three males are evaluated per litter rather than one. A 10% effect across male pups would be detected 5% of the time if one pup per litter was evaluated, but these effects would be detected 66% of the time if three pups per litter were evaluated. Taken together, this study provides a well-defined dose response of DEHP-induced RTMs and demonstrates that retention of more adult F1 and F2 males per litter, animals that were already produced, increases the ability to detect RTMs and presumably other low-incidence phenomena. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Blystone, Chad R AU - Kissling, Grace E AU - Bishop, Jack B AU - Chapin, Robert E AU - Wolfe, Gary W AU - Foster, Paul M D AD - Department of Health andHuman Services, National Institute of Environmental Health, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 640 EP - 646 VL - 116 IS - 2 KW - Diethylhexyl Phthalate KW - C42K0PH13C KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Abnormalities, Drug-Induced KW - No-Observed-Adverse-Effect Level KW - Dose-Response Relationship, Drug KW - Monte Carlo Method KW - Male KW - Female KW - Diethylhexyl Phthalate -- toxicity KW - Genitalia -- abnormalities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733989902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Determination+of+the+di-%282-ethylhexyl%29+phthalate+NOAEL+for+reproductive+development+in+the+rat%3A+importance+of+the+retention+of+extra+animals+to+adulthood.&rft.au=Blystone%2C+Chad+R%3BKissling%2C+Grace+E%3BBishop%2C+Jack+B%3BChapin%2C+Robert+E%3BWolfe%2C+Gary+W%3BFoster%2C+Paul+M+D&rft.aulast=Blystone&rft.aufirst=Chad&rft.date=2010-08-01&rft.volume=116&rft.issue=2&rft.spage=640&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfq147 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-28 N1 - Date created - 2010-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Crit Rev Toxicol. 2000 Mar;30(2):197-252 [10759431] Toxicol Appl Pharmacol. 2000 Sep 1;167(2):87-99 [10964759] Toxicol Sci. 2000 Dec;58(2):339-49 [11099646] Toxicol Pathol. 2002 Jan-Feb;30(1):59-65 [11892727] Regul Toxicol Pharmacol. 2002 Oct;36(2):184-97 [12460753] Toxicol Sci. 2009 Aug;110(2):411-25 [19482887] Biometrics. 1986 Mar;42(1):183-6 [3719054] Regul Toxicol Pharmacol. 1995 Apr;21(2):296-306 [7644719] Environ Health Perspect. 1997 Feb;105 Suppl 1:199-205 [9114287] Toxicol Sci. 2008 Oct;105(2):235-59 [18281716] Biometrics. 1977 Jun;33(2):386-9 [884197] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfq147 ER - TY - JOUR T1 - Chronic infection and the origin of adaptive immune system. AN - 733641104; 20299160 AB - It has been speculated that the rise of the adaptive immune system in jawed vertebrates some 400 million years ago gave them a superior protection to detect and defend against pathogens that became more elusive and/or virulent to the host that had only innate immune system. First, this line of thought implies that adaptive immune system was a new, more sophisticated layer of host defense that operated independently of the innate immune system. Second, the natural consequence of this scenario would be that pathogens would have exercised so strong an evolutionary pressure that eventually no host could have afforded not to have an adaptive immune system. Neither of these arguments is supported by the facts. First, new experimental evidence has firmly established that operation of adaptive immune system is critically dependent on the ability of the innate immune system to detect invader-pathogens and second, the absolute majority of animal kingdom survives just fine with only an innate immune system. Thus, these data raise the dilemma: If innate immune system was sufficient to detect and protect against pathogens, why then did adaptive immune system develop in the first place? In contrast to the innate immune system, the adaptive immune system has one important advantage, precision. By precision I mean the ability of the defense system to detect and remove the target, for example, infected cells, without causing unwanted bystander damage of surrounding tissue. While the target precision per se is not important for short-term immune response, it becomes a critical factor when the immune response is long-lasting, as during chronic infection. In this paper I would like to propose new, "toxic index" hypothesis where I argue that the need to reduce the collateral damage to the tissue during chronic infection(s) was the evolutionary pressure that led to the development of the adaptive immune system. Copyright 2010 Elsevier Ltd. All rights reserved. JF - Medical hypotheses AU - Usharauli, David AD - T Cell Tolerance and Memory Section (Ghost Lab), Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 4, Room 111, 9000 Rockville Pike, Bethesda, MD 20892, USA. dusharauli@gmail.com Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 241 EP - 243 VL - 75 IS - 2 KW - Index Medicus KW - Animals KW - Vertebrates -- immunology KW - Infection -- immunology KW - Models, Immunological KW - Communicable Diseases -- immunology KW - Adaptive Immunity -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733641104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+hypotheses&rft.atitle=Chronic+infection+and+the+origin+of+adaptive+immune+system.&rft.au=Usharauli%2C+David&rft.aulast=Usharauli&rft.aufirst=David&rft.date=2010-08-01&rft.volume=75&rft.issue=2&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Medical+hypotheses&rft.issn=1532-2777&rft_id=info:doi/10.1016%2Fj.mehy.2010.02.031 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-20 N1 - Date created - 2010-07-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2002 Apr 12;296(5566):301-5 [11951032] Nat Rev Genet. 2010 Jan;11(1):47-59 [19997068] Nature. 1968 May 4;218(5140):426-30 [4172071] Australas Ann Med. 1969 Nov;18(4):345-8 [5373981] Science. 1970 Sep 11;169(3950):1042-9 [4194660] Sci Am. 1973 Jul;229(1):52-60 [4723145] Cold Spring Harb Symp Quant Biol. 1989;54 Pt 1:1-13 [2700931] Immunol Today. 1992 Jan;13(1):11-6 [1739426] Annu Rev Immunol. 1994;12:991-1045 [8011301] Annu Rev Immunol. 1996;14:333-67 [8717518] Nature. 1997 Jul 24;388(6640):394-7 [9237759] Semin Immunol. 1998 Oct;10(5):351-3 [9799709] Science. 1999 May 21;284(5418):1313-8 [10334979] Science. 1961 Feb 3;133(3449):307-11 [13689158] Annu Rev Microbiol. 1960;14:341-58 [13789973] Immunity. 2004 Nov;21(5):607-15 [15539148] Nat Immunol. 2006 May;7(5):507-16 [16617337] Nat Med. 2007 Oct;13(10):1248-52 [17891146] Immunol Rev. 2009 Jan;227(1):221-33 [19120487] Nature. 2009 Jan 29;457(7229):557-61 [19136945] Nature. 2009 Jul 9;460(7252):269-73 [19494813] Nature. 2004 Jul 8;430(6996):174-80 [15241406] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mehy.2010.02.031 ER - TY - JOUR T1 - B2 attenuates polyglutamine-expanded androgen receptor toxicity in cell and fly models of spinal and bulbar muscular atrophy. AN - 733295744; 20336775 AB - Expanded polyglutamine tracts cause neurodegeneration through a toxic gain-of-function mechanism. Generation of inclusions is a common feature of polyglutamine diseases and other protein misfolding disorders. Inclusion formation is likely to be a defensive response of the cell to the presence of unfolded protein. Recently, the compound B2 has been shown to increase inclusion formation and decrease toxicity of polyglutamine-expanded huntingtin in cultured cells. We explored the effect of B2 on spinal and bulbar muscular atrophy (SBMA). SBMA is caused by expansion of polyglutamine in the androgen receptor (AR) and is characterized by the loss of motor neurons in the brainstem and spinal cord. We found that B2 increases the deposition of mutant AR into nuclear inclusions, without altering the ligand-induced aggregation, expression, or subcellular distribution of the mutant protein. The effect of B2 on inclusions was associated with a decrease in AR transactivation function. We show that B2 reduces mutant AR toxicity in cell and fly models of SBMA, further supporting the idea that accumulation of polyglutamine-expanded protein into inclusions is protective. Our findings suggest B2 as a novel approach to therapy for SBMA. JF - Journal of neuroscience research AU - Palazzolo, Isabella AU - Nedelsky, Natalia B AU - Askew, Caitlin E AU - Harmison, George G AU - Kasantsev, Aleksey G AU - Taylor, J Paul AU - Fischbeck, Kenneth H AU - Pennuto, Maria AD - Neurogenetics Branch, NINDS, NIH, Bethesda, MD, USA. Y1 - 2010/08/01/ PY - 2010 DA - 2010 Aug 01 SP - 2207 EP - 2216 VL - 88 IS - 10 KW - 5-(4-(4-chlorobenzoyl)-1-piperazinyl)-8-nitroquinoline KW - 0 KW - Ligands KW - Neuroprotective Agents KW - Nitroquinolines KW - Peptides KW - Piperazines KW - Receptors, Androgen KW - polyglutamine KW - 26700-71-0 KW - Index Medicus KW - Animals KW - Intracellular Space -- metabolism KW - Intranuclear Inclusion Bodies -- drug effects KW - Humans KW - Disease Models, Animal KW - Animals, Genetically Modified KW - Intranuclear Inclusion Bodies -- metabolism KW - Protein Multimerization KW - Rats KW - Intracellular Space -- drug effects KW - Drosophila melanogaster KW - Mutation KW - Cell Line KW - Receptors, Androgen -- genetics KW - Receptors, Androgen -- metabolism KW - Peptides -- metabolism KW - Piperazines -- pharmacology KW - Bulbo-Spinal Atrophy, X-Linked -- metabolism KW - Bulbo-Spinal Atrophy, X-Linked -- drug therapy KW - Nitroquinolines -- pharmacology KW - Neuroprotective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733295744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroscience+research&rft.atitle=B2+attenuates+polyglutamine-expanded+androgen+receptor+toxicity+in+cell+and+fly+models+of+spinal+and+bulbar+muscular+atrophy.&rft.au=Palazzolo%2C+Isabella%3BNedelsky%2C+Natalia+B%3BAskew%2C+Caitlin+E%3BHarmison%2C+George+G%3BKasantsev%2C+Aleksey+G%3BTaylor%2C+J+Paul%3BFischbeck%2C+Kenneth+H%3BPennuto%2C+Maria&rft.aulast=Palazzolo&rft.aufirst=Isabella&rft.date=2010-08-01&rft.volume=88&rft.issue=10&rft.spage=2207&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroscience+research&rft.issn=1097-4547&rft_id=info:doi/10.1002%2Fjnr.22389 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-26 N1 - Date created - 2010-06-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Neurol. 1998 Aug;44(2):249-54 [9708548] Neuron. 2009 Aug 13;63(3):316-28 [19679072] Cell. 1999 Mar 19;96(6):857-68 [10102273] J Cell Biol. 1999 May 3;145(3):481-90 [10225950] J Cell Biol. 1999 Sep 20;146(6):1239-54 [10491388] Brain. 2005 Mar;128(Pt 3):659-70 [15659427] Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11402-7 [16076956] Science. 2006 Mar 10;311(5766):1471-4 [16469881] Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4246-51 [16537516] Neuron. 1999 Dec;24(4):879-92 [10624951] J Biol Chem. 2000 Jul 7;275(27):20853-60 [10779504] Science. 2001 Jul 20;293(5529):493-8 [11408619] Science. 2002 Jun 14;296(5575):1991-5 [12065827] Hum Mol Genet. 2002 Aug 15;11(17):1967-76 [12165558] Neurology. 2002 Sep 10;59(5):770-2 [12221177] Neuron. 2002 Aug 29;35(5):843-54 [12372280] Neuron. 2002 Aug 29;35(5):855-64 [12372281] J Biol Chem. 2002 Dec 27;277(52):50855-9 [12388541] Hum Mol Genet. 2003 Apr 1;12(7):749-57 [12651870] Nat Med. 2003 Jun;9(6):768-73 [12754502] Mol Cell Biol. 2003 Dec;23(23):8563-75 [14612401] J Biol Chem. 2004 Feb 27;279(9):8389-95 [14670946] Front Neuroendocrinol. 2004 Apr;25(1):1-26 [15183036] Nat Med. 2004 Jul;10 Suppl:S10-7 [15272267] Nature. 2004 Oct 14;431(7010):805-10 [15483602] Biochem Biophys Res Commun. 1986 Mar 13;135(2):397-402 [3457562] Biochem Biophys Res Commun. 1989 Jan 16;158(1):105-9 [2912441] Nature. 1991 Jul 4;352(6330):77-9 [2062380] Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5355-8 [8202492] Neurobiol Dis. 1997;3(4):313-23 [9173928] J Biol Chem. 1998 Feb 20;273(8):4416-23 [9468493] Hum Mol Genet. 2006 Jul 15;15(14):2225-38 [16772330] Exp Neurol. 2006 Jul;200(1):8-18 [16513111] Brain Pathol. 2006 Jul;16(3):218-27 [16911479] J Clin Invest. 2006 Oct;116(10):2663-72 [16981011] Mol Cell Biol. 2006 Nov;26(21):8122-35 [16923962] J Biol Chem. 2007 Feb 2;282(5):3157-64 [17121819] Neuropathol Appl Neurobiol. 2007 Apr;33(2):135-51 [17359355] Cancer Res. 2007 May 1;67(9):4514-23 [17483368] Nature. 2007 Jun 14;447(7146):859-63 [17568747] Hum Mol Genet. 2007 Jul 1;16(13):1593-603 [17470458] Annu Rev Neurosci. 2007;30:575-621 [17417937] Science. 2007 Jul 27;317(5837):516-9 [17588900] Nature. 2008 Apr 10;452(7188):713-8 [18337722] J Cell Biochem. 2008 May 15;104(2):511-24 [18022799] Cell. 1998 Oct 2;95(1):55-66 [9778247] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jnr.22389 ER - TY - JOUR T1 - Biotreatment of diesel waste by sequencing batch bioreactor operation mode (SBR) AN - 1777102692; 13256210 AB - The performance of a stirred tank bioreactor operated in sequencing batch operation mode (SBR) to treat diesel waste from storage tanks, was investigated. The SBR run in four cycles of 72 h, using optimized setpoints for pH, initial waste load, C:N ratio and agitation speed. Optimal conditions allowed the system to reach biodegradation percentages of 53.3, 96.0, 76.2 and 75.0% at the end of cycles one, two three and four, respectively. Investigations of microbial diversity showed changes in the microbial community members at the end of the cycle one. Significant reductions in the relative ecotoxicity were observed beginning with cycle two, and the reductions extended until the end of process. The SBR operation mode proved to be an efficient method for treating the diesel waste, allowing relevant reductions in the hydrocarbon content of the waste along with an increase in its environmental quality. JF - International Biodeterioration & Biodegradation AU - Gomes, Edelvio B AU - Silva, Ricardo F AU - Rosado, Alexandre S AU - Pereira, Nei AD - Laboratories of Bioprocess Development, Biochemical Engineering Department, Centre of Technology, Federal University of Rio de Janeiro, Avenida Athos da Silveira Ramos, 149 CEP 21949-900, Rio de Janeiro, Brazil Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 413 EP - 417 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 64 IS - 5 SN - 0964-8305, 0964-8305 KW - Advanced Polymers Abstracts (EP); Environmental Engineering Abstracts (EN); Composites Industry Abstracts (ED); Engineered Materials Abstracts, Ceramics (EC); Corrosion Abstracts (CO) KW - Biotreatment KW - Periodic process KW - Sequencing batch KW - Reduction KW - Storage tanks KW - Bioreactors KW - Wastes KW - Sequencing KW - Microorganisms KW - Diesel KW - Diesel fuels UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777102692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Biodeterioration+%26+Biodegradation&rft.atitle=Biotreatment+of+diesel+waste+by+sequencing+batch+bioreactor+operation+mode+%28SBR%29&rft.au=Gomes%2C+Edelvio+B%3BSilva%2C+Ricardo+F%3BRosado%2C+Alexandre+S%3BPereira%2C+Nei&rft.aulast=Gomes&rft.aufirst=Edelvio&rft.date=2010-08-01&rft.volume=64&rft.issue=5&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=International+Biodeterioration+%26+Biodegradation&rft.issn=09648305&rft_id=info:doi/10.1016%2Fj.ibiod.2010.04.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1016/j.ibiod.2010.04.003 ER - TY - JOUR T1 - Multipesticide residue assessment of agricultural soil and water in major farming areas in Benguet, Philippines AN - 1560087616; 2014-064885 AB - This study investigated the concentration and presence of pesticide residues in water and soil in Benguet, which is a vegetable producing region in the Philippines. Seventy-eight samples and 49 water samples were taken from different farms covering three municipalities in the province of Benguet and were analyzed using gas chromatography. Meteorological conditions of temperature and humidity were also taken. Thirty-four of the soil samples were found to be positive for pesticide residues. The most significant pesticide type with the highest concentration was technical endosulfan, with a mean concentration of 0.025 mg/kg, followed by endosulfan sulfate (0.015 mg/kg), chlorpyrifos (0.01 mg/kg), profenofos (0.003 mg/kg), chlorothanil, cypermethrin, and cylohathrin (all at 0.002 mg/kg). One water sample was found to be positive for pesticide residue of chlorpyrifos in municipality 2 at a concentration of 0.07 mg/L. The data also showed that endosulfan, which is restricted in the Philippines and banned in other countries, was found to be the most prevalent pesticide used (17.7%) and the second highest in concentration (0.015 mg/kg) in soil samples. The study also showed a relationship between temperature and pesticide concentration in soil. In conclusion, pesticide residues were found in soil and water samples in the farming areas of Benguet. Copyright 2010 Springer Science+Business Media, LLC JF - Archives of Environmental Contamination and Toxicology AU - Lu, Jinky Leilanie del Prado Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 175 EP - 181 PB - Springer, New York, NY VL - 59 IS - 2 SN - 0090-4341, 0090-4341 KW - water KW - soils KW - Luzon KW - Far East KW - Philippine Islands KW - agriculture KW - pollution KW - Benguet Phillipine Islands KW - pesticides KW - Asia KW - environmental analysis KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560087616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Environmental+Contamination+and+Toxicology&rft.atitle=Multipesticide+residue+assessment+of+agricultural+soil+and+water+in+major+farming+areas+in+Benguet%2C+Philippines&rft.au=Lu%2C+Jinky+Leilanie+del+Prado&rft.aulast=Lu&rft.aufirst=Jinky+Leilanie+del&rft.date=2010-08-01&rft.volume=59&rft.issue=2&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Archives+of+Environmental+Contamination+and+Toxicology&rft.issn=00904341&rft_id=info:doi/10.1007%2Fs00244-010-9478-5 L2 - http://www.springerlink.com/(4rb2jbyxcwtb1he1c13ybdmm)/app/home/journal.asp?referrer=parent&backto=linkingpublicationresults,1:100119,1 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. Reference includes data supplied by Springer Verlag, Berlin, Federal Republic of Germany N1 - Date revised - 2014-01-01 N1 - Number of references - 32 N1 - PubXState - NY N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2014-09-05 N1 - CODEN - AECTCV N1 - SubjectsTermNotLitGenreText - agriculture; Asia; Benguet Phillipine Islands; environmental analysis; Far East; Luzon; pesticides; Philippine Islands; pollution; soils; water DO - http://dx.doi.org/10.1007/s00244-010-9478-5 ER - TY - JOUR T1 - Recent advances in malaria research: new tools to understand an old enemy AN - 1464503203; 18714618 AB - Scientists who gathered at the most recent Keystone Symposia meeting on malaria described several advances, including applications of new technologies as well as new insights into pathogenesis and immunology. Enhanced tools to visualize the immune response to the Plasmodium pathogen, and systems biology approaches to interrogate host-parasite interactions, are altering our understanding of immunity and disease. At the same time, a partially effective subunit vaccine in human trials, and new models of highly protective human immunity, are raising expectations for immunological control of this ancient pandemic. JF - Expert Review of Anti-infective Therapy AU - do Rosario, Ana Paula Freitas AU - Langhorne, Jean AU - Duffy, Patrick E AU - Finney, Olivia C AD - super(1)Parasitology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK, patrick.duffy@nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 863 EP - 866 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 8 IS - 8 SN - 1478-7210, 1478-7210 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Human diseases KW - Immunology KW - Disease control KW - Malaria KW - Immunity KW - Pathogens KW - Defence mechanisms KW - Models KW - Public health KW - Plasmodium KW - pandemics KW - Reviews KW - Immune response KW - Vaccines KW - Host-parasite interactions KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1464503203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+Review+of+Anti-infective+Therapy&rft.atitle=Recent+advances+in+malaria+research%3A+new+tools+to+understand+an+old+enemy&rft.au=do+Rosario%2C+Ana+Paula+Freitas%3BLanghorne%2C+Jean%3BDuffy%2C+Patrick+E%3BFinney%2C+Olivia+C&rft.aulast=do+Rosario&rft.aufirst=Ana+Paula&rft.date=2010-08-01&rft.volume=8&rft.issue=8&rft.spage=863&rft.isbn=&rft.btitle=&rft.title=Expert+Review+of+Anti-infective+Therapy&rft.issn=14787210&rft_id=info:doi/10.1586%2Feri.10.77 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-11-01 N1 - Number of references - 1 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Human diseases; Immunology; Disease control; Malaria; Vaccines; Pathogens; Immunity; Defence mechanisms; Public health; pandemics; Reviews; Immune response; Host-parasite interactions; Models; Plasmodium DO - http://dx.doi.org/10.1586/eri.10.77 ER - TY - CPAPER T1 - Analysis of Macromolecules by Negative Stain Tomography T2 - 2010 Microscopy and Microanalysis Meeting (M&M 2010) AN - 1313005359; 6025036 JF - 2010 Microscopy and Microanalysis Meeting (M&M 2010) AU - Fera, Andrea Y1 - 2010/08/01/ PY - 2010 DA - 2010 Aug 01 KW - Macromolecules KW - Tomography KW - Stains UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313005359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Microscopy+and+Microanalysis+Meeting+%28M%26M+2010%29&rft.atitle=Analysis+of+Macromolecules+by+Negative+Stain+Tomography&rft.au=Fera%2C+Andrea&rft.aulast=Fera&rft.aufirst=Andrea&rft.date=2010-08-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Microscopy+and+Microanalysis+Meeting+%28M%26M+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.microscopy.org/MandM/2010/posters.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Localized hypermutability caused by chronic alkylation damage to a eukaryotic genome T2 - 2010 Gordon Research Conference on Mutagenesis AN - 1312967716; 6014761 JF - 2010 Gordon Research Conference on Mutagenesis AU - Roberts, Steven Y1 - 2010/08/01/ PY - 2010 DA - 2010 Aug 01 KW - Genomes KW - Alkylation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312967716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Mutagenesis&rft.atitle=Localized+hypermutability+caused+by+chronic+alkylation+damage+to+a+eukaryotic+genome&rft.au=Roberts%2C+Steven&rft.aulast=Roberts&rft.aufirst=Steven&rft.date=2010-08-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Mutagenesis&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=mutagen LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Mechanism for translesion DNA synthesis T2 - 2010 Gordon Research Conference on Mutagenesis AN - 1312965817; 6014773 JF - 2010 Gordon Research Conference on Mutagenesis AU - Yang, Wei Y1 - 2010/08/01/ PY - 2010 DA - 2010 Aug 01 KW - DNA biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312965817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Mutagenesis&rft.atitle=Mechanism+for+translesion+DNA+synthesis&rft.au=Yang%2C+Wei&rft.aulast=Yang&rft.aufirst=Wei&rft.date=2010-08-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Mutagenesis&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=mutagen LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Repair of DNA replication errors in budding yeast T2 - 2010 Gordon Research Conference on Mutagenesis AN - 1312952460; 6014777 JF - 2010 Gordon Research Conference on Mutagenesis AU - Kunkel, Thomas Y1 - 2010/08/01/ PY - 2010 DA - 2010 Aug 01 KW - Replication KW - DNA biosynthesis KW - DNA repair KW - Budding KW - Saccharomyces cerevisiae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312952460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Mutagenesis&rft.atitle=Repair+of+DNA+replication+errors+in+budding+yeast&rft.au=Kunkel%2C+Thomas&rft.aulast=Kunkel&rft.aufirst=Thomas&rft.date=2010-08-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Mutagenesis&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=mutagen LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Topoisomerases and genomic stability T2 - 2010 Gordon Research Conference on Mutagenesis AN - 1312928674; 6014781 JF - 2010 Gordon Research Conference on Mutagenesis AU - Pommier, Yves Y1 - 2010/08/01/ PY - 2010 DA - 2010 Aug 01 KW - genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312928674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Mutagenesis&rft.atitle=Topoisomerases+and+genomic+stability&rft.au=Pommier%2C+Yves&rft.aulast=Pommier&rft.aufirst=Yves&rft.date=2010-08-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Mutagenesis&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=mutagen LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Electron Microscopy Analysis Shows Insignificant Dermal Penetration of Titanium Dioxide from Sunscreen Formulations Containing Nanoparticles T2 - 2010 Microscopy and Microanalysis Meeting (M&M 2010) AN - 1312910980; 6025029 JF - 2010 Microscopy and Microanalysis Meeting (M&M 2010) AU - Baxa, Ulrich Y1 - 2010/08/01/ PY - 2010 DA - 2010 Aug 01 KW - titanium dioxide KW - Electron microscopy KW - Sunscreens KW - Titanium dioxide KW - Skin KW - nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312910980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Microscopy+and+Microanalysis+Meeting+%28M%26M+2010%29&rft.atitle=Electron+Microscopy+Analysis+Shows+Insignificant+Dermal+Penetration+of+Titanium+Dioxide+from+Sunscreen+Formulations+Containing+Nanoparticles&rft.au=Baxa%2C+Ulrich&rft.aulast=Baxa&rft.aufirst=Ulrich&rft.date=2010-08-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Microscopy+and+Microanalysis+Meeting+%28M%26M+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.microscopy.org/MandM/2010/posters.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Imaging-Genetics Applications in Child Psychiatry AN - 1125283273; 201227245 AB - Objective: To place imaging-genetics research in the context of child psychiatry. Method: A conceptual overview is provided, followed by discussion of specific research examples. Results: Imaging-genetics research is described linking brain function to two specific genes, for the serotonin-reuptake-transporter protein and a monoamine oxidase enzyme. Work is then described on phenotype selection in imaging genetics. Conclusions: Child psychiatry applications of imaging genetics are only beginning to emerge. The approach holds promise for advancing understandings of pathophysiology and therapeutics. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Pine, Daniel S AU - Ernst, Monique AU - Leibenluft, Ellen AD - National Institute of Mental Health Intramural Research Program, Mood and Anxiety Disorders Program daniel.pine@nih.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 772 EP - 782 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 49 IS - 8 SN - 0890-8567, 0890-8567 KW - imaging KW - genetics KW - anxiety KW - children and adolescents KW - Child psychiatry KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1125283273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Imaging-Genetics+Applications+in+Child+Psychiatry&rft.au=Pine%2C+Daniel+S%3BErnst%2C+Monique%3BLeibenluft%2C+Ellen&rft.aulast=Pine&rft.aufirst=Daniel&rft.date=2010-08-01&rft.volume=49&rft.issue=8&rft.spage=772&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1016%2Fj.jaac.2009.12.022 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Child psychiatry DO - http://dx.doi.org/10.1016/j.jaac.2009.12.022 ER - TY - JOUR T1 - A system and mathematical framework to model shear flow effects in biomedical DW-imaging and spectroscopy AN - 1017969050; 16700613 AB - The pulsed-field gradient (PFG) MR experiment enables one to measure particle displacements, velocities, and even higher moments of complex fluid motions. In diffusion-weighted MRI (DWI) in living tissue, where the PFG MRI experiment is used to measure diffusion, Brownian motion is assumed to dominate the displacements causing the observed signal loss. However, motions of water molecules caused by various active biological processes occurring at different length and time scales may also cause additional dephasing of magnetization and signal loss. To help understand their relative effects on the DWI signal attenuation, we used an integrated experimental and theoretical framework: a Rheo-NMR, which served as an experimental model system to precisely prescribe a microscopic velocity distribution; and a mathematical model that relates the DW signal intensity in the Rheo-NMR to experimental parameters that characterize the impressed velocity field. A technical innovation reported here is our use of 'natural' (in this case, polar) coordinates both to simplify the description the fluid motion within the Couette cell of the Rheo-NMR, as well as to acquire and reconstruct magnitude and phase MR images obtained within it. We use this integrated model system to demonstrate how shear flows appears as pseudo-diffusion in magnitude DW MR signals obtained using PFG spin-echo (PGSE) NMR and MRI sequences. Our results lead us to reinterpret the possible causes of signal loss in DWI in vivo, in particular to revise and generalize the previous notion of intra-voxel incoherent motion (IVIM) in order to describe activity driven flows that appear as pseudo-diffusion over multiple length and time scales in living tissues. JF - NMR in Biomedicine AU - Nevo, Uri AU - Ozarslan, Evren AU - Komlosh, Michal E AU - Koay, Cheng Guan AU - Sarlls, Joelle E AU - Basser, Peter J AD - Department of Biomedical Engineering, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel, pjbasser@helix.nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 734 EP - 744 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 23 IS - 7 SN - 1099-1492, 1099-1492 KW - Biotechnology and Bioengineering Abstracts KW - Brownian motion KW - Diffusion KW - Magnetic resonance imaging KW - Mathematical models KW - N.M.R. KW - Spectroscopy KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017969050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=A+system+and+mathematical+framework+to+model+shear+flow+effects+in+biomedical+DW-imaging+and+spectroscopy&rft.au=Nevo%2C+Uri%3BOzarslan%2C+Evren%3BKomlosh%2C+Michal+E%3BKoay%2C+Cheng+Guan%3BSarlls%2C+Joelle+E%3BBasser%2C+Peter+J&rft.aulast=Nevo&rft.aufirst=Uri&rft.date=2010-08-01&rft.volume=23&rft.issue=7&rft.spage=734&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=10991492&rft_id=info:doi/10.1002%2Fnbm.1591 L2 - http://onlinelibrary.wiley.com/doi/10.1002/nbm.1591/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Mathematical models; Magnetic resonance imaging; Diffusion; N.M.R.; Spectroscopy; Brownian motion DO - http://dx.doi.org/10.1002/nbm.1591 ER - TY - CPAPER T1 - Oncoviruses from My Land to Yours-at Risk Populations Across the Globe T2 - 1st World Congress of Virus and Infections (WCVI 2010) AN - 1312962958; 6022221 JF - 1st World Congress of Virus and Infections (WCVI 2010) AU - Duran, Deborah Y1 - 2010/07/31/ PY - 2010 DA - 2010 Jul 31 KW - Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312962958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=1st+World+Congress+of+Virus+and+Infections+%28WCVI+2010%29&rft.atitle=Oncoviruses+from+My+Land+to+Yours-at+Risk+Populations+Across+the+Globe&rft.au=Duran%2C+Deborah&rft.aulast=Duran&rft.aufirst=Deborah&rft.date=2010-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=1st+World+Congress+of+Virus+and+Infections+%28WCVI+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/wcvi2010/Program-wcvi.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Dangerous liaisons: Fanconi anemia and toxic nonhomologous end joining in DNA crosslink repair. AN - 748966864; 20670885 AB - The proper choice of repair pathway is critical to tolerating various types of DNA damage. In a recent issue of Molecular Cell, Adamo et al. (2010), along with a second report (Pace et al., 2010), describe how the Fanconi anemia (FA) pathway is involved in preventing aberrant DNA repair. These studies suggest a potentially significant new opportunity for the treatment of FA. Copyright 2010 Elsevier Inc. All rights reserved. JF - Molecular cell AU - Bunting, Samuel F AU - Nussenzweig, André AD - Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Y1 - 2010/07/30/ PY - 2010 DA - 2010 Jul 30 SP - 164 EP - 166 VL - 39 IS - 2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748966864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cell&rft.atitle=Dangerous+liaisons%3A+Fanconi+anemia+and+toxic+nonhomologous+end+joining+in+DNA+crosslink+repair.&rft.au=Bunting%2C+Samuel+F%3BNussenzweig%2C+Andr%C3%A9&rft.aulast=Bunting&rft.aufirst=Samuel&rft.date=2010-07-30&rft.volume=39&rft.issue=2&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Molecular+cell&rft.issn=1097-4164&rft_id=info:doi/10.1016%2Fj.molcel.2010.07.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-20 N1 - Date created - 2010-07-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Science. 2010 Jul 9;329(5988):219-23 [20538911] Mol Cell. 2010 Jul 9;39(1):25-35 [20598602] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.molcel.2010.07.016 ER - TY - JOUR T1 - Association between Lead and Cadmium and Reproductive Hormones in Peripubertal U.S. Girls AN - 1677902822; 14160345 AB - Lead (Pb) and cadmium (Cd) are known reproductive toxicants thought to disrupt hormone production throughout sensitive developmental windows, although this has not been previously examined in nationally representative peripubertal children. We examined the association between blood Pb and urinary Cd concentrations and the reproductive hormones inhibin B and luteinizing hormone (LH) in girls 6-11 years of age who participated in the cross-sectional Third National Health and Nutrition Examination Survey (NHANES III) (1988-1994). Pb (micrograms per deciliter) was measured in whole blood, and Cd was measured in urine (nanograms per milliliter). Inhibin B (picograms per milliliter) and LH (milli-International units per milliliter) were measured in residual sera for 705 girls. Survey logistic regression was used to estimate associations with pubertal onset based on inhibin B concentration > 35 pg/mL or LH concentration > 0.4 mIU/mL, and multinomial logistic regression was used to estimate the association between Pb and increasing categories of hormone concentrations. High Pb ( greater than or equal to 5 mu g/dL) was inversely associated with inhibin B > 35 pg/mL [odds ratio (OR) = 0.26; 95% confidence interval (CI), 0.11-0.60; compared with Pb & 1 mu g/dL]. At 10 and 11 years of age, girls with low Pb (& 1 mu g/dL) had significantly higher inhibin B than did girls with moderate (1-4.99 mu g/dL) or high Pb ( greater than or equal to 5 mu g/dL). In the subsample of 260 girls with levels of inhibin B above the level of detection and using survey regression modeling, inhibin B levels were lower among girls with both high Pb and high Cd ( beta = -0.52; 95% CI, -0.09 to -1.04) than among girls with high Pb alone ( beta = -0.35; 95% CI, -0.13 to -0.57), relative to girls with low Pb and low Cd. Higher Pb was inversely associated with inhibin B, a marker of follicular development, and estimated effects suggestive of pubertal delays appeared to be stronger in the context of higher Cd concentrations. These data underscore the importance of Pb and Cd as reproductive toxicants for young girls. JF - Environmental Health Perspectives AU - Gollenberg, Audra L AU - Hediger, Mary L AU - Lee, Peter A AU - Himes, John H AU - Buck Louis, Germaine M AD - Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland, USA Y1 - 2010/07/30/ PY - 2010 DA - 2010 Jul 30 SP - 1782 EP - 1787 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 118 IS - 2 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - heavy metals KW - inhibin B KW - luteinizing hormone KW - NHANES KW - puberty KW - Estimates KW - Logistics KW - Girls KW - Regression KW - Health KW - Cadmium KW - Hormones KW - Nanostructure KW - Lead (metal) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677902822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Association+between+Lead+and+Cadmium+and+Reproductive+Hormones+in+Peripubertal+U.S.+Girls&rft.au=Gollenberg%2C+Audra+L%3BHediger%2C+Mary+L%3BLee%2C+Peter+A%3BHimes%2C+John+H%3BBuck+Louis%2C+Germaine+M&rft.aulast=Gollenberg&rft.aufirst=Audra&rft.date=2010-07-30&rft.volume=118&rft.issue=2&rft.spage=1782&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1001943 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1289/ehp.1001943 ER - TY - JOUR T1 - Structural convergence among diverse, toxic beta-sheet ion channels. AN - 748984043; 20608696 AB - Recent studies show that an array of beta-sheet peptides, including N-terminally truncated Abeta peptides (Abeta(11-42/17-42)), K3 (a beta(2)-microglobulin fragment), and protegrin-1 (PG-1) peptides form ion channel-like structures and elicit single channel ion conductance when reconstituted in lipid bilayers and induce cell damage through cell calcium overload. Striking similarities are observed in the dimensions of these toxic channels irrespective of their amino acid sequences. However, the intriguing question of preferred channel sizes is still unresolved. Here, exploiting ssNMR-based, U-shaped, beta-strand-turn-beta-strand coordinates, we modeled truncated Abeta peptide (p3) channels with different sizes (12- to 36-mer). Molecular dynamics (MD) simulations show that optimal channel sizes of the ion channels presenting toxic ionic flux range between 16- and 24-mer. This observation is in good agreement with channel dimensions imaged by AFM for Abeta(9-42), K3 fragment, and PG-1 channels and highlights the bilayer-supported preferred toxic beta-channel sizes and organization, regardless of the peptide sequence. JF - The journal of physical chemistry. B AU - Jang, Hyunbum AU - Teran Arce, Fernando AU - Ramachandran, Srinivasan AU - Capone, Ricardo AU - Lal, Ratnesh AU - Nussinov, Ruth AD - Center for Cancer Research Nanobiology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA. Y1 - 2010/07/29/ PY - 2010 DA - 2010 Jul 29 SP - 9445 EP - 9451 VL - 114 IS - 29 KW - Amyloid beta-Peptides KW - 0 KW - Antimicrobial Cationic Peptides KW - Ion Channels KW - Lipid Bilayers KW - Peptides KW - protegrin-1 KW - Index Medicus KW - Protein Structure, Secondary KW - Amyloid beta-Peptides -- chemistry KW - Antimicrobial Cationic Peptides -- chemistry KW - Peptides -- chemistry KW - Microscopy, Atomic Force KW - Lipid Bilayers -- chemistry KW - Molecular Dynamics Simulation KW - Ion Channels -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748984043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+physical+chemistry.+B&rft.atitle=Structural+convergence+among+diverse%2C+toxic+beta-sheet+ion+channels.&rft.au=Jang%2C+Hyunbum%3BTeran+Arce%2C+Fernando%3BRamachandran%2C+Srinivasan%3BCapone%2C+Ricardo%3BLal%2C+Ratnesh%3BNussinov%2C+Ruth&rft.aulast=Jang&rft.aufirst=Hyunbum&rft.date=2010-07-29&rft.volume=114&rft.issue=29&rft.spage=9445&rft.isbn=&rft.btitle=&rft.title=The+journal+of+physical+chemistry.+B&rft.issn=1520-5207&rft_id=info:doi/10.1021%2Fjp104073k LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-23 N1 - Date created - 2010-07-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1998 May 29;273(22):13379-82 [9593665] Biophys J. 1998 Apr;74(4):1622-39 [9545028] Biochemistry. 1999 Aug 24;38(34):11189-96 [10460176] J Biol Chem. 2004 Nov 5;279(45):46363-6 [15385542] Science. 2005 Jan 7;307(5706):42-3; 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6010124 JF - 2010 Gordon Research Conference on In Vivo Magnetic Resonance AU - Koretsky, Alan Y1 - 2010/07/25/ PY - 2010 DA - 2010 Jul 25 KW - Particulates KW - Brain KW - rodents KW - Neurons KW - Tracking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312969175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+In+Vivo+Magnetic+Resonance&rft.atitle=Micron+scale+particles+for+tracking+new+neurons+in+the+rodent+brain&rft.au=Koretsky%2C+Alan&rft.aulast=Koretsky&rft.aufirst=Alan&rft.date=2010-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+In+Vivo+Magnetic+Resonance&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=invivo LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Histone variant CenH3, nonhistone Scm3, and AT-rich DNA organize an H2A/H2B-deficient nucleosome in budding yeast T2 - 2010 Gordon Research Conference on Chromatin Structure & Function AN - 1312968273; 6009818 JF - 2010 Gordon Research Conference on Chromatin Structure & Function AU - Wu, Carl Y1 - 2010/07/25/ PY - 2010 DA - 2010 Jul 25 KW - Nucleosomes KW - Histones KW - Budding KW - Saccharomyces cerevisiae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312968273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Chromatin+Structure+%26+Function&rft.atitle=Histone+variant+CenH3%2C+nonhistone+Scm3%2C+and+AT-rich+DNA+organize+an+H2A%2FH2B-deficient+nucleosome+in+budding+yeast&rft.au=Wu%2C+Carl&rft.aulast=Wu&rft.aufirst=Carl&rft.date=2010-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Chromatin+Structure+%26+Function&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=chromatin LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Iron-sulfur cluster assembly and human disease T2 - 7th International Biometals Symposium (BioMetals 2010) AN - 1312957054; 6021449 JF - 7th International Biometals Symposium (BioMetals 2010) AU - Rouault, Tracey Y1 - 2010/07/25/ PY - 2010 DA - 2010 Jul 25 KW - Human diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312957054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+International+Biometals+Symposium+%28BioMetals+2010%29&rft.atitle=Iron-sulfur+cluster+assembly+and+human+disease&rft.au=Rouault%2C+Tracey&rft.aulast=Rouault&rft.aufirst=Tracey&rft.date=2010-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+International+Biometals+Symposium+%28BioMetals+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.biochem.arizona.edu/biometals2010/schedule.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Cadmium induces transcription independent of calcium mobilization T2 - 7th International Biometals Symposium (BioMetals 2010) AN - 1312896565; 6021438 JF - 7th International Biometals Symposium (BioMetals 2010) AU - Tvermoes, Brooke Y1 - 2010/07/25/ PY - 2010 DA - 2010 Jul 25 KW - Calcium mobilization KW - Transcription KW - Cadmium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312896565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+International+Biometals+Symposium+%28BioMetals+2010%29&rft.atitle=Cadmium+induces+transcription+independent+of+calcium+mobilization&rft.au=Tvermoes%2C+Brooke&rft.aulast=Tvermoes&rft.aufirst=Brooke&rft.date=2010-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+International+Biometals+Symposium+%28BioMetals+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.biochem.arizona.edu/biometals2010/schedule.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Activatable molecular probes for cancer diagnosis T2 - 2010 Gordon Research Conference on Lasers In Medicine & Biology AN - 1312889447; 6010228 JF - 2010 Gordon Research Conference on Lasers In Medicine & Biology AU - Kobayashi, Hisataka Y1 - 2010/07/25/ PY - 2010 DA - 2010 Jul 25 KW - Cancer KW - Probes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312889447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Lasers+In+Medicine+%26+Biology&rft.atitle=Activatable+molecular+probes+for+cancer+diagnosis&rft.au=Kobayashi%2C+Hisataka&rft.aulast=Kobayashi&rft.aufirst=Hisataka&rft.date=2010-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Lasers+In+Medicine+%26+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=lasersmed LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Origin and use of spontaneous BOLD fMRI fluctuations T2 - 2010 Gordon Research Conference on In Vivo Magnetic Resonance AN - 1312882552; 6010138 JF - 2010 Gordon Research Conference on In Vivo Magnetic Resonance AU - Duyn, Jeff Y1 - 2010/07/25/ PY - 2010 DA - 2010 Jul 25 KW - Functional magnetic resonance imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312882552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+In+Vivo+Magnetic+Resonance&rft.atitle=Origin+and+use+of+spontaneous+BOLD+fMRI+fluctuations&rft.au=Duyn%2C+Jeff&rft.aulast=Duyn&rft.aufirst=Jeff&rft.date=2010-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+In+Vivo+Magnetic+Resonance&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=invivo LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Fractionated Radiation Therapy Can Induce a Molecular Profile for Therapeutic Targeting AN - 876226949; 14136257 AB - To examine the possibility of using fractionated radiation in a unique way with molecular targeted therapy, gene expression profiles of prostate carcinoma cells treated with 10Gy radiation administered either as a single dose or as fractions of 2Gy 5 and 1Gy 10 were examined by microarray analysis. Compared to the single dose, the fractionated irradiation resulted in significant increases in differentially expressed genes in both cell lines, with more robust changes in PC3 cells than in DU145 cells. The differentially expressed genes (>twofold change; P < 0.05) were clustered and their ontological annotations evaluated. In PC3 cells genes regulating immune and stress response, cell cycle and apoptosis were significantly up-regulated by multifractionated radiation compared to single-dose radiation. Ingenuity Pathway Analysis (IPA) of the differentially expressed genes revealed that immune response and cardiovascular genes were in the top functional category in PC3 cells and cell-to-cell signaling in DU145 cells. RT-PCR analysis showed that a flexure point for gene expression occurred at the 6th-8th fraction and AKT inhibitor perifosine produced enhanced cell killing after 1Gy 8 fractionated radiation in PC3 and DU145 cells compared to single dose. This study suggests that fractionated radiation may be a uniquely exploitable, non-oncogene-addiction stress pathway for molecular therapeutic targeting. JF - Radiation Research AU - John-Aryankalayil, Molykutty AU - Palayoor, Sanjeewani T AU - Cerna, David AU - Simone, Charles B AU - Falduto, Michael T AU - Magnuson, Scott R AU - Coleman, CNorman Y1 - 2010/07/23/ PY - 2010 DA - 2010 Jul 23 SP - 446 EP - 458 PB - Radiation Research Society VL - 174 IS - 4 SN - 0033-7587, 0033-7587 KW - Toxicology Abstracts KW - AKT protein KW - Radiation KW - X:24390 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876226949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Fractionated+Radiation+Therapy+Can+Induce+a+Molecular+Profile+for+Therapeutic+Targeting&rft.au=John-Aryankalayil%2C+Molykutty%3BPalayoor%2C+Sanjeewani+T%3BCerna%2C+David%3BSimone%2C+Charles+B%3BFalduto%2C+Michael+T%3BMagnuson%2C+Scott+R%3BColeman%2C+CNorman&rft.aulast=John-Aryankalayil&rft.aufirst=Molykutty&rft.date=2010-07-23&rft.volume=174&rft.issue=4&rft.spage=446&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR2105.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Radiation DO - http://dx.doi.org/10.1667/RR2105.1 ER - TY - JOUR T1 - Moonshine illuminates a developmental role for regulated transcription elongation. AN - 734005274; 20643345 AB - Mutations in the zebrafish gene moonshine, encoding the ortholog of TIF1 gamma, cause profound anemia and embryonic lethality. In a recent issue of Cell, Bai et al. provide evidence that these defects arise from inefficient transcription elongation, implicating elongation as an important point of regulation during cell differentiation and development. (c) 2010 Elsevier Inc. All rights reserved. JF - Developmental cell AU - Gilchrist, Daniel A AU - Adelman, Karen AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2010/07/20/ PY - 2010 DA - 2010 Jul 20 SP - 9 EP - 10 VL - 19 IS - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734005274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+cell&rft.atitle=Moonshine+illuminates+a+developmental+role+for+regulated+transcription+elongation.&rft.au=Gilchrist%2C+Daniel+A%3BAdelman%2C+Karen&rft.aulast=Gilchrist&rft.aufirst=Daniel&rft.date=2010-07-20&rft.volume=19&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Developmental+cell&rft.issn=1878-1551&rft_id=info:doi/10.1016%2Fj.devcel.2010.07.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-30 N1 - Date created - 2010-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell. 2008 Apr 11;30(1):7-10 [18406322] Nature. 2000 Nov 16;408(6810):366-9 [11099044] Genes Dev. 2003 Apr 15;17(8):1009-18 [12672691] PLoS Biol. 2004 Aug;2(8):E237 [15314655] Cell. 2010 Feb 19;140(4):491-503 [20178742] Cell Cycle. 2008 Jun 1;7(11):1539-44 [18469524] Science. 2008 Dec 19;322(5909):1845-8 [19056941] Science. 2009 Jul 24;325(5939):471-3 [19628867] Mol Cell. 2009 Nov 25;36(4):541-6 [19941815] Comment On: Cell. 2010 Jul 9;142(1):133-43 [20603019] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.devcel.2010.07.003 ER - TY - JOUR T1 - The 3-4 loop of an archaeal glutamate transporter homolog experiences ligand-induced structural changes and is essential for transport. AN - 733999629; 20615993 AB - Glutamatergic synaptic transmission is terminated by members of the excitatory amino acid transporter (EAAT) family of proteins that remove glutamate from the synaptic cleft by transporting it into surrounding glial cells. Recent structures of a bacterial homolog suggest that major motions within the transmembrane domain translocate the substrate across the membrane. However, the events leading to this large structural rearrangement are much less clear. Two reentrant loops have been proposed to act as extracellular and intracellular gates, but whether other regions of these proteins play a role in the transport process is unknown. We hypothesized that transport-related conformational changes could change the solvent accessibilities of affected residues, as reflected in protease sensitivity or small-molecule reactivity. In the model system Glt(Ph), an archaeal EAAT homologue from Pyrococcus horikoshii, limited trypsin proteolysis experiments initially identified a site in the long extracellular loop that stretches between helices 3 and 4 that becomes protected from proteolysis in the presence of a substrate, L-aspartate, or an inhibitor, DL-TBOA in the presence of Na(+), the cotransported ion. Using a combination of site-directed cysteine-scanning mutagenesis and fluorescein-5-maleimide labeling we found that positions throughout the loop experience these ligand-induced conformational changes. By selectively cleaving the 3-4 loop (via introduced Factor Xa sites) we demonstrate that it plays a vital role in the transport process; though structurally intact, the cleaved proteins are unable to transport aspartate. These results inculcate the 3-4 loop as an important player in the transport process, a finding not predicted by any of the available crystal structures of Glt(Ph). JF - Proceedings of the National Academy of Sciences of the United States of America AU - Compton, Emma L R AU - Taylor, Erin M AU - Mindell, Joseph A AD - Membrane Transport Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2010/07/20/ PY - 2010 DA - 2010 Jul 20 SP - 12840 EP - 12845 VL - 107 IS - 29 KW - Amino Acid Transport System X-AG KW - 0 KW - Fluoresceins KW - Glutamates KW - Ligands KW - Mutant Proteins KW - fluorescein 5-maleimide KW - 75350-46-8 KW - Trypsin KW - EC 3.4.21.4 KW - Factor Xa KW - EC 3.4.21.6 KW - Index Medicus KW - Animals KW - Protein Structure, Secondary KW - Cattle KW - Factor Xa -- metabolism KW - Fluoresceins -- metabolism KW - Mutant Proteins -- metabolism KW - Protein Processing, Post-Translational KW - Mutant Proteins -- chemistry KW - Molecular Sequence Data KW - Biological Transport KW - Trypsin -- metabolism KW - Amino Acid Sequence KW - Substrate Specificity KW - Structure-Activity Relationship KW - Amino Acid Transport System X-AG -- chemistry KW - Glutamates -- metabolism KW - Pyrococcus horikoshii -- metabolism KW - Amino Acid Transport System X-AG -- metabolism KW - Amino Acid Transport System X-AG -- antagonists & inhibitors KW - Sequence Homology, Amino Acid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733999629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=The+3-4+loop+of+an+archaeal+glutamate+transporter+homolog+experiences+ligand-induced+structural+changes+and+is+essential+for+transport.&rft.au=Compton%2C+Emma+L+R%3BTaylor%2C+Erin+M%3BMindell%2C+Joseph+A&rft.aulast=Compton&rft.aufirst=Emma+L&rft.date=2010-07-20&rft.volume=107&rft.issue=29&rft.spage=12840&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.1003046107 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-01 N1 - Date created - 2010-07-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14282-7 [10588697] Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20752-7 [19926849] Prog Neurobiol. 2001 Sep;65(1):1-105 [11369436] J Biol Chem. 2002 Feb 8;277(6):3985-92 [11724778] Biochemistry. 2003 Nov 11;42(44):12981-8 [14596613] Mol Pharmacol. 2004 Apr;65(4):1008-15 [15044631] Brain Res Brain Res Rev. 2004 Jul;45(3):250-65 [15210307] Nature. 2004 Oct 14;431(7010):811-8 [15483603] J Biol Chem. 1995 Jul 14;270(28):17017-24 [7622523] Biochemistry. 1996 May 14;35(19):6150-6 [8634258] Biochemistry. 1997 Nov 25;36(47):14572-6 [9398175] FASEB J. 1998 Oct;12(13):1281-99 [9761772] Neuron. 1998 Sep;21(3):623-32 [9768848] Neuron. 1998 Dec;21(6):1487-98 [9883740] J Biol Chem. 1999 Aug 27;274(35):24617-24 [10455127] J Neurosci. 2005 Feb 16;25(7):1730-6 [15716409] Curr Protein Pept Sci. 2005 Dec;6(6):501-12 [16381600] J Biol Chem. 2006 Oct 6;281(40):29788-96 [16877378] Nature. 2007 Jan 25;445(7126):387-93 [17230192] Nat Struct Mol Biol. 2007 May;14(5):365-71 [17435767] J Biol Chem. 2007 Aug 24;282(34):24547-53 [17588938] Nat Protoc. 2008;3(2):256-66 [18274528] Biophys J. 2008 Sep;95(5):2292-300 [18515371] IUBMB Life. 2008 Sep;60(9):609-19 [18543277] J Biol Chem. 2008 Sep 26;283(39):26391-400 [18658151] J Biol Chem. 2009 Jun 26;284(26):17540-8 [19380583] Nature. 2009 Dec 17;462(7275):880-5 [19924125] Biochemistry. 2010 May 4;49(17):3511-3 [20349989] J Biol Chem. 2000 Mar 31;275(13):9684-9 [10734120] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.1003046107 ER - TY - CPAPER T1 - Visualizing cells and viruses at molecular resolution with 3D electron microscopy: Progress and challenges T2 - 2010 Gordon Research Conference on Diffraction Methods In Structural Biology AN - 1312895701; 5998001 JF - 2010 Gordon Research Conference on Diffraction Methods In Structural Biology AU - Subramaniam, Sriram Y1 - 2010/07/18/ PY - 2010 DA - 2010 Jul 18 KW - Electron microscopy KW - Viruses UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312895701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Diffraction+Methods+In+Structural+Biology&rft.atitle=Visualizing+cells+and+viruses+at+molecular+resolution+with+3D+electron+microscopy%3A+Progress+and+challenges&rft.au=Subramaniam%2C+Sriram&rft.aulast=Subramaniam&rft.aufirst=Sriram&rft.date=2010-07-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Diffraction+Methods+In+Structural+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=diffrac LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Identification of a Novel Staphylococcus aureus Two-Component Leukotoxin Using Cell Surface Proteomics AN - 754554136; 13317504 AB - Staphylococcus aureus is a prominent human pathogen and leading cause of bacterial infection in hospitals and the community. Community-associated methicillin-resistant S. aureus (CA-MRSA) strains such as USA300 are highly virulent and, unlike hospital strains, often cause disease in otherwise healthy individuals. The enhanced virulence of CA-MRSA is based in part on increased ability to produce high levels of secreted molecules that facilitate evasion of the innate immune response. Although progress has been made, the factors that contribute to CA-MRSA virulence are incompletely defined. We analyzed the cell surface proteome (surfome) of USA300 strain LAC to better understand extracellular factors that contribute to the enhanced virulence phenotype. A total of 113 identified proteins were associated with the surface of USA300 during the late-exponential phase of growth in vitro. Protein A was the most abundant surface molecule of USA300, as indicated by combined Mascot score following analysis of peptides by tandem mass spectrometry. Unexpectedly, we identified a previously uncharacterized two-component leukotoxin-herein named LukS-H and LukF-G (LukGH)-as two of the most abundant surface-associated proteins of USA300. Rabbit antibody specific for LukG indicated it was also freely secreted by USA300 into culture media. We used wild-type and isogenic lukGH deletion strains of USA300 in combination with human PMN pore formation and lysis assays to identify this molecule as a leukotoxin. Moreover, LukGH synergized with PVL to enhance lysis of human PMNs in vitro, and contributed to lysis of PMNs after phagocytosis. We conclude LukGH is a novel two-component leukotoxin with cytolytic activity toward neutrophils, and thus potentially contributes to S. aureus virulence. JF - PLoS ONE AU - Ventura, Christy L AU - Malachowa, Natalia AU - Hammer, Carl H AU - Nardone, Glenn A AU - Robinson, Mary Ann AU - Kobayashi, Scott D AU - DeLeo, Frank R AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America Y1 - 2010/07/16/ PY - 2010 DA - 2010 Jul 16 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - 7 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Cell surface KW - protein A KW - Drug resistance KW - Leukocytes (neutrophilic) KW - Pathogens KW - Infection KW - Mass spectroscopy KW - Virulence KW - Pores KW - Antibodies KW - Cytolytic activity KW - proteomics KW - Immune response KW - Staphylococcus aureus KW - Phagocytosis KW - Media (culture) KW - Hospitals KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754554136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Identification+of+a+Novel+Staphylococcus+aureus+Two-Component+Leukotoxin+Using+Cell+Surface+Proteomics&rft.au=Ventura%2C+Christy+L%3BMalachowa%2C+Natalia%3BHammer%2C+Carl+H%3BNardone%2C+Glenn+A%3BRobinson%2C+Mary+Ann%3BKobayashi%2C+Scott+D%3BDeLeo%2C+Frank+R&rft.aulast=Ventura&rft.aufirst=Christy&rft.date=2010-07-16&rft.volume=5&rft.issue=7&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0011634 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Cell surface; Drug resistance; protein A; Leukocytes (neutrophilic); Pathogens; Infection; Mass spectroscopy; Virulence; Antibodies; Pores; Cytolytic activity; Immune response; proteomics; Phagocytosis; Media (culture); Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1371/journal.pone.0011634 ER - TY - CPAPER T1 - Innovative Molecular Analysis Technologies T2 - 2010 Genetic Alliance Annual Conference AN - 1312897521; 6000520 JF - 2010 Genetic Alliance Annual Conference AU - Aragon, Richard Y1 - 2010/07/16/ PY - 2010 DA - 2010 Jul 16 KW - innovations KW - Technology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312897521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Genetic+Alliance+Annual+Conference&rft.atitle=Innovative+Molecular+Analysis+Technologies&rft.au=Aragon%2C+Richard&rft.aulast=Aragon&rft.aufirst=Richard&rft.date=2010-07-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Genetic+Alliance+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.geneticalliance.org/conference2010.agenda LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - eyeGENE - National Ophthalmic Disease Genotyping Network T2 - 2010 Genetic Alliance Annual Conference AN - 1312897489; 6000519 JF - 2010 Genetic Alliance Annual Conference AU - Tumminia, Santa AU - O'Brien, Joan AU - Williams, Brad Y1 - 2010/07/16/ PY - 2010 DA - 2010 Jul 16 KW - Genotyping UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312897489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Genetic+Alliance+Annual+Conference&rft.atitle=eyeGENE+-+National+Ophthalmic+Disease+Genotyping+Network&rft.au=Tumminia%2C+Santa%3BO%27Brien%2C+Joan%3BWilliams%2C+Brad&rft.aulast=Tumminia&rft.aufirst=Santa&rft.date=2010-07-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Genetic+Alliance+Annual+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.geneticalliance.org/conference2010.agenda LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - The Construction and Use of Log-Odds Substitution Scores for Multiple Sequence Alignment AN - 856753637; 13315468 AB - Most pairwise and multiple sequence alignment programs seek alignments with optimal scores. Central to defining such scores is selecting a set of substitution scores for aligned amino acids or nucleotides. For local pairwise alignment, substitution scores are implicitly of log-odds form. We now extend the log-odds formalism to multiple alignments, using Bayesian methods to construct "BILD" ("Bayesian Integral Log-odds") substitution scores from prior distributions describing columns of related letters. This approach has been used previously only to define scores for aligning individual sequences to sequence profiles, but it has much broader applicability. We describe how to calculate BILD scores efficiently, and illustrate their uses in Gibbs sampling optimization procedures, gapped alignment, and the construction of hidden Markov model profiles. BILD scores enable automated selection of optimal motif and domain model widths, and can inform the decision of whether to include a sequence in a multiple alignment, and the selection of insertion and deletion locations. Other applications include the classification of related sequences into subfamilies, and the definition of profile-profile alignment scores. Although a fully realized multiple alignment program must rely upon more than substitution scores, many existing multiple alignment programs can be modified to employ BILD scores. We illustrate how simple BILD score based strategies can enhance the recognition of DNA binding domains, including the Api-AP2 domain in Toxoplasma gondii and Plasmodium falciparum. Multiple sequence alignment is a fundamental tool of biological research, widely used to identify important regions of DNA or protein molecules, to infer their biological functions, to reconstruct ancestries, and in numerous other applications. The effectiveness and accuracy of sequence comparison programs depends crucially upon the quality of the scoring systems they use to measure sequence similarity. To compare pairs of DNA or protein sequences, the best strategy for constructing similarity measures has long been understood, but there has been a lack of consensus about how to measure similarity among multiple (i.e. more than two) sequences. In this paper, we describe a natural generalization to multiple alignment of the accepted measure of pairwise similarity. A large variety of methods that are used to compare and analyze DNA or protein molecules, or to model protein domain families, could be rendered more sensitive and precise by adopting this similarity measure. We illustrate how our measure can enhance the recognition of important DNA binding domains. JF - PLoS Computational Biology AU - Altschul, Stephen F AU - Wootton, John C AU - Zaslavsky, Elena AU - Yu, Yi-Kuo AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2010/07/15/ PY - 2010 DA - 2010 Jul 15 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 USA VL - 6 IS - 7 SN - 1553-734X, 1553-734X KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Parasites KW - Classification KW - Toxoplasma gondii KW - Nucleotide sequence KW - Illustrations KW - DNA KW - Plasmodium falciparum KW - Identification KW - Nucleotides KW - Amino acid sequence KW - Q1 08185:Genetics and evolution KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856753637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Computational+Biology&rft.atitle=The+Construction+and+Use+of+Log-Odds+Substitution+Scores+for+Multiple+Sequence+Alignment&rft.au=Altschul%2C+Stephen+F%3BWootton%2C+John+C%3BZaslavsky%2C+Elena%3BYu%2C+Yi-Kuo&rft.aulast=Altschul&rft.aufirst=Stephen&rft.date=2010-07-15&rft.volume=6&rft.issue=7&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Computational+Biology&rft.issn=1553734X&rft_id=info:doi/10.1371%2Fjournal.pcbi.1000852 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Parasites; Classification; Nucleotide sequence; Illustrations; DNA; Identification; Nucleotides; Amino acid sequence; Toxoplasma gondii; Plasmodium falciparum DO - http://dx.doi.org/10.1371/journal.pcbi.1000852 ER - TY - JOUR T1 - An endocrine-disrupting chemical, fenvalerate, induces cell cycle progression and collagen type I expression in human uterine leiomyoma and myometrial cells AN - 760208923; 13204022 AB - Fenvalerate (Fen), widely used for its high insecticidal potency and low mammalian toxicity, is classified as an endocrine-disrupting chemical. Recently, Fen has received great attention for its adverse effects on human reproductive health. In this study, we found that Fen (10 mu M) had a stimulatory effect on the growth of both cell lines at 24h compared with controls by MTS (p <0.01) and BrdU (p <0.01) assays in hormonally responsive uterine leiomyoma (UtLM) cells and normal uterine smooth muscle cells (UtSMC). Flow cytometry results showed that Fen enhanced the escape of cells from the G sub(0)-G sub(1) checkpoint and promoted progression of both cell types into the S phase. An Annexin V assay showed that Fen had an anti-apoptotic effect on both cell types. By Real-time PCR, we found that collagen I mRNA expression increased (p <0.05) in Fen-treated cells compared to controls, although it was greater in UtLM tumor cells. Accordingly, Fen increased (p <0.05) collagen I protein levels in both cell lysate and supernatant when compared to controls. To further test the mechanism of Fen's effects, transactivation and competitive binding assays were done. The results showed Fen did not significantly stimulate luciferase activity at concentrations of 0.1 mu M, 1.0 mu M or 10.0 mu M in either of the cell types. Competitive binding assays revealed that the affinity of Fen binding to estrogen receptors (ERs) was non-detectable compared to E sub(2). Our data show that Fen can stimulate the growth of both UtLM cells and UtSMC, which involves a combination of enhanced cell cycle progression and inhibition of apoptosis. Also this compound can increase collagen I expression, at both mRNA and protein levels. Interestingly, the ER is less likely involved in either the hyperplasia or extracellular matrix (ECM) overproduction induced by Fen. Our results indicate that Fen exposure could be considered a novel risk factor for uterine fibroids through molecular mechanisms that do not directly involve the ERs. JF - Toxicology Letters AU - Gao, Xiaohua AU - Yu, Linda AU - Castro, Lysandra AU - Moore, Alicia B AU - Hermon, Tonia AU - Bortner, Carl AU - Sifre, Maria AU - Dixon, Darlene AD - Comparative Pathobiology Group, Cellular and Molecular Pathology Branch, NTP, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States Y1 - 2010/07/15/ PY - 2010 DA - 2010 Jul 15 SP - 133 EP - 141 PB - Elsevier Science, Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland VL - 196 IS - 3 SN - 0378-4274, 0378-4274 KW - Environment Abstracts; Toxicology Abstracts KW - Leiomyoma KW - Myometrium KW - Fenvalerate KW - Cell growth KW - ECM KW - Collagen type I KW - Smooth muscle KW - Molecular modelling KW - Apoptosis KW - endocrine disruptors KW - Endocrine disruptors KW - Cell cycle KW - tumors KW - Tumor cells KW - Flow cytometry KW - Gene expression KW - Risk factors KW - Polymerase chain reaction KW - Collagen (type I) KW - myometrium KW - Uterus KW - Muscles KW - Toxicity KW - Hyperplasia KW - S phase KW - Extracellular matrix KW - fenvalerate KW - Proteins KW - Reproduction KW - Estrogen receptors KW - Annexin V KW - Side effects KW - estrogens KW - X 24330:Agrochemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760208923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=An+endocrine-disrupting+chemical%2C+fenvalerate%2C+induces+cell+cycle+progression+and+collagen+type+I+expression+in+human+uterine+leiomyoma+and+myometrial+cells&rft.au=Gao%2C+Xiaohua%3BYu%2C+Linda%3BCastro%2C+Lysandra%3BMoore%2C+Alicia+B%3BHermon%2C+Tonia%3BBortner%2C+Carl%3BSifre%2C+Maria%3BDixon%2C+Darlene&rft.aulast=Gao&rft.aufirst=Xiaohua&rft.date=2010-07-15&rft.volume=196&rft.issue=3&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2010.03.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Smooth muscle; Molecular modelling; Uterus; Apoptosis; Fenvalerate; Endocrine disruptors; Cell cycle; Toxicity; Tumor cells; Gene expression; Flow cytometry; Hyperplasia; S phase; Risk factors; Extracellular matrix; Polymerase chain reaction; Collagen (type I); Estrogen receptors; Side effects; Annexin V; myometrium; endocrine disruptors; fenvalerate; Muscles; Proteins; tumors; Reproduction; estrogens DO - http://dx.doi.org/10.1016/j.toxlet.2010.03.004 ER - TY - JOUR T1 - PM, carbon, and PAH emissions from a diesel generator fuelled with soy-biodiesel blends AN - 759310141; 13202757 AB - Biodiesels have received increasing attention as alternative fuels for diesel engines and generators. This study investigates the emissions of particulate matter (PM), total carbon (TC), e.g., organic/elemental carbons, and polycyclic aromatic hydrocarbons (PAHs) from a diesel generator fuelled with soy-biodiesel blends. Among the tested diesel blends (B0, B10 (10vol% soy-biodiesel), B20, and B50), B20 exhibited the lowest PM emission concentration despite the loads (except the 5kW case), whereas B10 displayed lower PM emission factors when operating at 0 and 10kW than the other fuel blends. The emission concentrations or factors of EC, OC, and TC were the lowest when B10 or B20 was used regardless of the loading. Under all tested loads, the average concentrations of total-PAHs emitted from the generator using the B10 and B20 were lower (by 38% and 28%, respectively) than those using pure petroleum diesel fuel (B0), while the emission factors of total-PAHs decreased with an increasing ratio of biodiesel to premium diesel. With an increasing loading, although the brake specific fuel consumption decreased, the energy efficiency increased despite the bio/petroleum diesel ratio. Therefore, soy-biodiesel is promising for use as an alternative fuel for diesel generators to increase energy efficiency and reduce the PM, carbon, and PAH emissions. JF - Journal of Hazardous Materials AU - Tsai, Jen-Hsiung AU - Chen, Shui-Jen AU - Huang, Kuo-Lin AU - Lin, Yuan-Chung AU - Lee, Wen-Jhy AU - Lin, Chih-Chung AU - Lin, Wen-Yinn AD - Department of Environmental Engineering and Science, National Pingtung University of Science and Technology, 1 Shieh-Fu Rd., Nei Pu 91207, Pingtung, Taiwan Y1 - 2010/07/15/ PY - 2010 DA - 2010 Jul 15 SP - 237 EP - 243 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 179 IS - 1-3 SN - 0304-3894, 0304-3894 KW - Toxicology Abstracts; Environment Abstracts; Pollution Abstracts KW - Biodiesel KW - Organic carbon KW - PAH KW - Brake specific fuel consumption KW - Generator KW - Fuel technology KW - Energy efficiency KW - Polycyclic aromatic hydrocarbons KW - Fuels KW - Particulate matter KW - biofuels KW - Particulates KW - Carbon KW - Petroleum KW - Emissions KW - polycyclic aromatic hydrocarbons KW - Diesel KW - Diesel engines KW - Biofuels KW - ENA 03:Energy KW - P 0000:AIR POLLUTION KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759310141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hazardous+Materials&rft.atitle=PM%2C+carbon%2C+and+PAH+emissions+from+a+diesel+generator+fuelled+with+soy-biodiesel+blends&rft.au=Tsai%2C+Jen-Hsiung%3BChen%2C+Shui-Jen%3BHuang%2C+Kuo-Lin%3BLin%2C+Yuan-Chung%3BLee%2C+Wen-Jhy%3BLin%2C+Chih-Chung%3BLin%2C+Wen-Yinn&rft.aulast=Tsai&rft.aufirst=Jen-Hsiung&rft.date=2010-07-15&rft.volume=179&rft.issue=1-3&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hazardous+Materials&rft.issn=03043894&rft_id=info:doi/10.1016%2Fj.jhazmat.2010.02.085 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Polycyclic aromatic hydrocarbons; Carbon; Petroleum; Fuels; Particulate matter; Diesel; Biofuels; Energy efficiency; Fuel technology; biofuels; Emissions; polycyclic aromatic hydrocarbons; Particulates; Diesel engines DO - http://dx.doi.org/10.1016/j.jhazmat.2010.02.085 ER - TY - JOUR T1 - The Conserved Tarp Actin Binding Domain Is Important for Chlamydial Invasion AN - 754556618; 13315977 AB - The translocated actin recruiting phosphoprotein (Tarp) is conserved among all pathogenic chlamydial species. Previous reports identified single C. trachomatis Tarp actin binding and proline rich domains required for Tarp mediated actin nucleation. A peptide antiserum specific for the Tarp actin binding domain was generated and inhibited actin polymerization in vitro and C. trachomatis entry in vivo, indicating an essential role for Tarp in chlamydial pathogenesis. Sequence analysis of Tarp orthologs from additional chlamydial species and C. trachomatis serovars indicated multiple putative actin binding sites. In order to determine whether the identified actin binding domains are functionally conserved, GST-Tarp fusions from multiple chlamydial species were examined for their ability to bind and nucleate actin. Chlamydial Tarps harbored variable numbers of actin binding sites and promoted actin nucleation as determined by in vitro polymerization assays. Our findings indicate that Tarp mediated actin binding and nucleation is a conserved feature among diverse chlamydial species and this function plays a critical role in bacterial invasion of host cells. Chlamydiae are bacterial obligate intracellular pathogens responsible for multiple human and veterinary diseases. The induction of cytoskeletal rearrangements to promote chlamydial internalization is partially mediated by a type III secreted effector protein called Tarp that is translocated upon contact with host cells and independently nucleates actin filament formation. Tarp from a C. trachomatis lymphogranuloma venereum (LGV) strain consists of a tyrosine-rich repeat domain, a proline-rich domain required for oligomerization, and a single actin binding domain. Oligomerization is required to bring multiple actin monomers together to initiate actin filament formation by a mechanism distinct from host actin nucleators. Here we have examined Tarp from several other strains of chlamydiae and find that certain of these contain up to four actin binding domains. Tarp fragments bearing multiple actin binding domains nucleate actin in in vitro assays even in the absence of the oligomerization domain. This suggests that Tarp from different chlamydial species may utilize hybrid mechanisms to induce actin nucleation. Determination of virulence determinants in chlamydiae is challenging due to the lack of tractable genetic systems. The direct introduction of anti-Tarp actin binding domain antibodies into the cytosol of host cells inhibited entry and thus demonstrates an essential role for Tarp in chlamydial pathogenesis. JF - PLoS Pathogens AU - Jewett, Travis J AU - Miller, Natalie J AU - Dooley, Cheryl A AU - Hackstadt, Ted AD - Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America Y1 - 2010/07/15/ PY - 2010 DA - 2010 Jul 15 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 USA VL - 6 IS - 7 SN - 1553-7366, 1553-7366 KW - Microbiology Abstracts B: Bacteriology KW - Proline KW - Polymerization KW - Lymphogranuloma venereum KW - Oligomerization KW - Pathogens KW - Virulence KW - Monomers KW - Nucleation KW - Cytoskeleton KW - Antibodies KW - Phosphoproteins KW - Hybrids KW - Cytosol KW - Actin KW - veterinary diseases KW - Filaments KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754556618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Pathogens&rft.atitle=The+Conserved+Tarp+Actin+Binding+Domain+Is+Important+for+Chlamydial+Invasion&rft.au=Jewett%2C+Travis+J%3BMiller%2C+Natalie+J%3BDooley%2C+Cheryl+A%3BHackstadt%2C+Ted&rft.aulast=Jewett&rft.aufirst=Travis&rft.date=2010-07-15&rft.volume=6&rft.issue=7&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Pathogens&rft.issn=15537366&rft_id=info:doi/10.1371%2Fjournal.ppat.1000997 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Proline; Polymerization; Oligomerization; Lymphogranuloma venereum; Pathogens; Cytoskeleton; Nucleation; Monomers; Virulence; Antibodies; Phosphoproteins; Hybrids; Cytosol; Actin; Filaments; veterinary diseases DO - http://dx.doi.org/10.1371/journal.ppat.1000997 ER - TY - JOUR T1 - GliomaPredict: a clinically useful tool for assigning glioma patients to specific molecular subtypes AN - 754556606; 13315962 AB - Advances in generating genome-wide gene expression data have accelerated the development of molecular-based tumor classification systems. Tools that allow the translation of such molecular classification schemas from research into clinical applications are still missing in the emerging era of personalized medicine. We developed GliomaPredict as a computational tool that allows the fast and reliable classification of glioma patients into one of six previously published stratified subtypes based on sets of extensively validated classifiers derived from hundreds of glioma transcriptomic profiles. Our tool utilizes a principle component analysis (PCA)-based approach to generate a visual representation of the analyses, quantifies the confidence of the underlying subtype assessment and presents results as a printable PDF file. GliomaPredict tool is implemented as a plugin application for the widely-used GenePattern framework. GliomaPredict provides a user-friendly, clinically applicable novel platform for instantly assigning gene expression-based subtype in patients with gliomas thereby aiding in clinical trial design and therapeutic decision-making. Implemented as a user-friendly diagnostic tool, we expect that in time GliomaPredict, and tools like it, will become routinely used in translational/clinical research and in the clinical care of patients with gliomas. JF - BMC Medical Informatics and Decision Making AU - Li, Aiguo AU - Bozdag, Serdar AU - Kotliarov, Yuri AU - Fine, Howard A AD - Neuro-Oncology Branch, National Cancer Institute, National Institutes of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, MD 20892, USA Y1 - 2010/07/15/ PY - 2010 DA - 2010 Jul 15 SP - 38 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 10 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Classification systems KW - Translation KW - Data processing KW - Informatics KW - Therapeutic applications KW - Tumors KW - Computer applications KW - Clinical trials KW - Gene expression KW - Brain tumors KW - Decision making KW - Classification KW - Glioma KW - N3 11002:Computational & theoretical neuroscience KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754556606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Medical+Informatics+and+Decision+Making&rft.atitle=GliomaPredict%3A+a+clinically+useful+tool+for+assigning+glioma+patients+to+specific+molecular+subtypes&rft.au=Li%2C+Aiguo%3BBozdag%2C+Serdar%3BKotliarov%2C+Yuri%3BFine%2C+Howard+A&rft.aulast=Li&rft.aufirst=Aiguo&rft.date=2010-07-15&rft.volume=10&rft.issue=&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=BMC+Medical+Informatics+and+Decision+Making&rft.issn=1472-6947&rft_id=info:doi/10.1186%2F1472-6947-10-38 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Classification systems; Translation; Data processing; Informatics; Therapeutic applications; Tumors; Computer applications; Clinical trials; Brain tumors; Gene expression; Decision making; Classification; Glioma DO - http://dx.doi.org/10.1186/1472-6947-10-38 ER - TY - JOUR T1 - Motualevic acids and analogs: Synthesis and antimicrobial structure-activity relationships AN - 754538446; 13258307 AB - Synthesis of the marine natural products motualevic acids A, E, and analogs in which modifications have been made to the [Omega]-brominated lipid (E)-14,14-dibromotetra-deca-2,13-dienoic acid or amino acid unit are reported, together with antimicrobial activities against Staphylococcus aureus, methicillin-resistant S. aureus, Enterococcus faecium, and vancomycin-resistant Enterococcus. JF - Bioorganic and Medicinal Chemistry Letters AU - Cheruku, Pradeep AU - Keffer, Jessica L AU - Dogo-Isonagie, Cajetan AU - Bewley, Carole A AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA, caroleb@mail.nih.gov Y1 - 2010/07/15/ PY - 2010 DA - 2010 Jul 15 SP - 4108 EP - 4111 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 20 IS - 14 SN - 0960-894X, 0960-894X KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - Acids KW - Enterococcus KW - A 01340:Antibiotics & Antimicrobials KW - W 30915:Pharmaceuticals & Vaccines KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754538446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Motualevic+acids+and+analogs%3A+Synthesis+and+antimicrobial+structure-activity+relationships&rft.au=Cheruku%2C+Pradeep%3BKeffer%2C+Jessica+L%3BDogo-Isonagie%2C+Cajetan%3BBewley%2C+Carole+A&rft.aulast=Cheruku&rft.aufirst=Pradeep&rft.date=2010-07-15&rft.volume=20&rft.issue=14&rft.spage=4108&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2010.05.073 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Acids; Enterococcus DO - http://dx.doi.org/10.1016/j.bmcl.2010.05.073 ER - TY - JOUR T1 - FastMEDUSA: a parallelized tool to infer gene regulatory networks AN - 753678786; 13240722 AB - Motivation: In order to construct gene regulatory networks of higher organisms from gene expression and promoter sequence data efficiently, we developed FastMEDUSA. In this parallelized version of the regulatory network-modeling tool MEDUSA, expression and sequence data are shared among a user-defined number of processors on a single multi-core machine or cluster. Our results show that FastMEDUSA allows a more efficient utilization of computational resources. While the determination of a regulatory network of brain tumor in Homo sapiens takes 12 days with MEDUSA, FastMEDUSA obtained the same results in 6 h by utilizing 100 processors.Availability: Source code and documentation of FastMEDUSA are available at https://wiki.nci.nih.gov/display/NOBbioinf/FastMEDUSAContact: hfineail.nih.govSupplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Bozdag, Serdar AU - Li, Aiguo AU - Wuchty, Stefan AU - Fine, Howard A AD - super(1) Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Diseases and Stroke Y1 - 2010/07/15/ PY - 2010 DA - 2010 Jul 15 SP - 1792 EP - 1793 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 26 IS - 14 SN - 1367-4803, 1367-4803 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Gene expression KW - Brain tumors KW - Computer programs KW - Promoters KW - Data processing KW - Regulatory sequences KW - Bioinformatics KW - Computational neuroscience KW - N3 11002:Computational & theoretical neuroscience KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753678786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=FastMEDUSA%3A+a+parallelized+tool+to+infer+gene+regulatory+networks&rft.au=Bozdag%2C+Serdar%3BLi%2C+Aiguo%3BWuchty%2C+Stefan%3BFine%2C+Howard+A&rft.aulast=Bozdag&rft.aufirst=Serdar&rft.date=2010-07-15&rft.volume=26&rft.issue=14&rft.spage=1792&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtq275 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Brain tumors; Gene expression; Promoters; Computer programs; Data processing; Regulatory sequences; Bioinformatics; Computational neuroscience DO - http://dx.doi.org/10.1093/bioinformatics/btq275 ER - TY - JOUR T1 - Microtubule-disrupting chemotherapeutics result in enhanced proteasome-mediated degradation and disappearance of tubulin in neural cells. AN - 733987004; 20587529 AB - We sought to examine the effects of microtubule-targeting agents (MTA) on neural cells to better understand the problem of neurotoxicity, their principal side effect, and to possibly develop a model of clinical toxicity. Studies showed that microtubule-depolymerizing agents (MDA) not only disassembled microtubules in neural HCN2 cells but also led to rapid disappearance of tubulin, and that this was specific for MDAs. Tubulin levels decreased to 20% as early as 8 hours after adding vincristine, and to 1% to 30% (mean, 9.8 +/- 7.6%; median of 7%) after 100 nmol/L vincristine for 24 hours. This disappearance was reversible. An increase in both glu-terminated and acetylated tubulin, markers of stable tubulin, preceded reaccumulation of soluble tubulin, suggesting a priority for stabilizing tubulin first as microtubules before replenishing the soluble pool. Similar results were shown with other MDAs. Furthermore, microtubule reassembly did not arise from a central focus but instead appeared to involve dispersed nucleation, as evidenced by the appearance of small, stable microtubule stubs throughout the cytoplasm. In contrast, experiments with four nonneural "normal" cell lines and four cancer cell lines resulted in microtubule destabilization but only modest tubulin degradation. Evidence for proteasome-mediated degradation was obtained by demonstrating that adding a proteasome inhibitor before vincristine prevented tubulin disappearance. In summary, MDAs lead to rapid disappearance of tubulin in neural but not in other normal or cancer cells. These results underscore the fine control that occurs in neural cells and may further our understanding of neurotoxicity following MDAs. (c)2010 AACR. JF - Cancer research AU - Huff, Lyn M AU - Sackett, Dan L AU - Poruchynsky, Marianne S AU - Fojo, Tito AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute and Laboratory of Integrative and Medical Biophysics, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA. lyn@mail.nih.gov Y1 - 2010/07/15/ PY - 2010 DA - 2010 Jul 15 SP - 5870 EP - 5879 VL - 70 IS - 14 KW - Antibiotics, Antineoplastic KW - 0 KW - Antineoplastic Agents KW - Tubulin KW - Doxorubicin KW - 80168379AG KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Index Medicus KW - Doxorubicin -- pharmacology KW - DNA Damage KW - Antibiotics, Antineoplastic -- pharmacology KW - Humans KW - Cell Line, Tumor KW - Neurons -- metabolism KW - Proteasome Endopeptidase Complex -- metabolism KW - Neurons -- drug effects KW - Neurons -- cytology KW - Microtubules -- metabolism KW - Tubulin -- metabolism KW - Microtubules -- drug effects KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733987004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Microtubule-disrupting+chemotherapeutics+result+in+enhanced+proteasome-mediated+degradation+and+disappearance+of+tubulin+in+neural+cells.&rft.au=Huff%2C+Lyn+M%3BSackett%2C+Dan+L%3BPoruchynsky%2C+Marianne+S%3BFojo%2C+Tito&rft.aulast=Huff&rft.aufirst=Lyn&rft.date=2010-07-15&rft.volume=70&rft.issue=14&rft.spage=5870&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-09-4281 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-24 N1 - Date created - 2010-07-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer. 2002 Mar 15;94(6):1815-20 [11920545] Biochem Biophys Res Commun. 2009 Oct 16;388(2):345-9 [19665001] Mol Cancer Ther. 2003 May;2(5):427-36 [12748304] Cancer Res. 2003 Jun 1;63(11):2794-801 [12782584] Oncogene. 2003 Dec 8;22(56):9075-86 [14663486] Nat Rev Cancer. 2004 Apr;4(4):253-65 [15057285] J Neurol Neurosurg Psychiatry. 1969 Aug;32(4):297-304 [4309019] J Cell Biol. 1984 Jul;99(1 Pt 1):155-65 [6203916] J Cell Biol. 1985 Nov;101(5 Pt 1):1763-72 [3902854] Cancer Res. 1991 Apr 15;51(8):2212-22 [2009540] J Neurooncol. 1993 Jan;15(1):23-7 [8384253] Trends Biochem Sci. 2010 May;35(5):288-97 [20116259] J Cell Biol. 1993 Jul;122(2):349-59 [8320258] Biochem Pharmacol. 2001 Dec 1;62(11):1469-80 [11728383] Jpn J Clin Oncol. 1994 Aug;24(4):199-204 [8072198] Med Pediatr Oncol. 1995 Apr;24(4):235-40 [7700168] Neuroscience. 1994 Dec;63(4):1081-99 [7700510] J Surg Oncol. 1996 Jan;61(1):68-83 [8544465] Curr Opin Cell Biol. 1997 Feb;9(1):29-36 [9013665] J Biol Chem. 1997 Jul 4;272(27):17118-25 [9202030] Biochem Cell Biol. 1997;75(2):103-17 [9250358] Blood. 1963 May;21:640-7 [14018556] J Cell Sci. 2006 Oct 15;119(Pt 20):4155-63 [17038542] Nat Rev Neurosci. 2007 May;8(5):368-78 [17453017] Expert Opin Investig Drugs. 2007 Jul;16(7):923-6 [17594179] Curr Cancer Drug Targets. 2007 Dec;7(8):713-29 [18220532] Curr Cancer Drug Targets. 2007 Dec;7(8):730-42 [18220533] IUBMB Life. 2008 Mar;60(3):165-70 [18380008] Cell Cycle. 2008 Apr 1;7(7):940-9 [18414063] Cell Biol Int. 2009 Jan;33(1):57-64 [18957327] Curr Med Chem. 2009;16(11):1315-24 [19355888] J Biol Chem. 2009 Jun 19;284(25):17039-51 [19339240] Neurobiol Dis. 2009 Aug;35(2):270-7 [19464369] J Neurol. 2002 Jan;249(1):9-17 [11954874] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-09-4281 ER - TY - JOUR T1 - Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice. AN - 733985480; 20224069 AB - The NF-E2 related factor 2 (Nrf2)-antioxidant response element (ARE) pathway is essential for protection against oxidative injury and inflammation including hyperoxia-induced acute lung injury. Microarray expression profiling revealed that lung peroxisome proliferator activated receptor gamma (PPARgamma) induction is suppressed in hyperoxia-susceptible Nrf2-deficient (Nrf2(-/-)) mice compared with wild-type (Nrf2(+/+)) mice. PPARgamma has pleiotropic beneficial effects including antiinflammation in multiple tissues. We tested the hypothesis that PPARgamma is an important determinant of pulmonary responsivity to hyperoxia regulated by Nrf2. A computational bioinformatic method was applied to screen potential AREs in the Pparg promoter for Nrf2 binding. The functional role of a potential ARE was investigated by in vitro promoter analysis. A role for PPARgamma in hyperoxia-induced acute lung injury was determined by temporal silencing of PPARgamma via intranasal delivery of PPARgamma-specific interference RNA and by administration of a PPARgamma ligand 15-deoxy-Delta(12,14)-prostaglandin J(2) in mice. Deletion or site-directed mutagenesis of a potential ARE spanning -784/-764 sequence significantly attenuated hyperoxia-increased Pparg promoter activity in airway epithelial cells overexpressing Nrf2, indicating that the -784/-764 ARE is critical for Nrf2-regulated PPARgamma expression. Mice with decreased lung PPARgamma by specific interference RNA treatment had significantly augmented hyperoxia-induced pulmonary inflammation and injury. 15 Deoxy-Delta(12,14)-prostaglandin J(2) administration significantly reduced hyperoxia-induced lung inflammation and edema in Nrf2(+/+), but not in Nrf2(-/-) mice. Results indicate for the first time that Nrf2-driven PPARgamma induction has an essential protective role in pulmonary oxidant injury. Our observations provide new insights into the therapeutic potential of PPARgamma in airway oxidative inflammatory disorders. JF - American journal of respiratory and critical care medicine AU - Cho, Hye-Youn AU - Gladwell, Wesley AU - Wang, Xuting AU - Chorley, Brian AU - Bell, Douglas AU - Reddy, Sekhar P AU - Kleeberger, Steven R AD - Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Dr., Building 101, MD D-201, Research Triangle Park, NC 27709, USA. cho2@niehs.nih.gov Y1 - 2010/07/15/ PY - 2010 DA - 2010 Jul 15 SP - 170 EP - 182 VL - 182 IS - 2 KW - 15-deoxy-delta(12,14)-prostaglandin J2 KW - 0 KW - Immunologic Factors KW - NF-E2-Related Factor 2 KW - PPAR gamma KW - RNA, Small Interfering KW - Prostaglandin D2 KW - RXY07S6CZ2 KW - Abridged Index Medicus KW - Index Medicus KW - Epithelial Cells -- metabolism KW - Prostaglandin D2 -- pharmacology KW - Animals KW - Gene Silencing KW - Prostaglandin D2 -- analogs & derivatives KW - Immunologic Factors -- pharmacology KW - Mice KW - Lung -- metabolism KW - NF-E2-Related Factor 2 -- physiology KW - Acute Lung Injury -- prevention & control KW - Acute Lung Injury -- metabolism KW - PPAR gamma -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733985480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+and+critical+care+medicine&rft.atitle=Nrf2-regulated+PPAR%7Bgamma%7D+expression+is+critical+to+protection+against+acute+lung+injury+in+mice.&rft.au=Cho%2C+Hye-Youn%3BGladwell%2C+Wesley%3BWang%2C+Xuting%3BChorley%2C+Brian%3BBell%2C+Douglas%3BReddy%2C+Sekhar+P%3BKleeberger%2C+Steven+R&rft.aulast=Cho&rft.aufirst=Hye-Youn&rft.date=2010-07-15&rft.volume=182&rft.issue=2&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+and+critical+care+medicine&rft.issn=1535-4970&rft_id=info:doi/10.1164%2Frccm.200907-1047OC LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-14 N1 - Date created - 2010-07-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Physiol Genomics. 2005 Jun 16;22(1):108-17 [15784698] Shock. 2005 Jul;24(1):59-65 [15988322] J Exp Med. 2005 Jul 4;202(1):47-59 [15998787] Proc Am Thorac Soc. 2005;2(3):226-31 [16222042] J Immunol. 2005 Nov 15;175(10):6968-75 [16272357] Pulm Pharmacol Ther. 2006;19(1):39-46 [16286236] Inflamm Res. 2005 Nov;54(11):464-70 [16307220] Inflamm Res. 2006 Jan;55(1):10-5 [16328104] J Dent Res. 2006 Feb;85(2):156-61 [16434734] J Clin Invest. 2006 Apr;116(4):984-95 [16585964] Pediatr Pulmonol. 2006 Jun;41(6):558-69 [16617452] Curr Opin Pharmacol. 2006 Jun;6(3):263-70 [16580256] Immunity. 2006 May;24(5):601-10 [16713977] J Allergy Clin Immunol. 2006 Jul;118(1):120-7 [16815147] Nephrol Dial Transplant. 2006 Aug;21(8):2096-105 [16728429] Fundam Clin Pharmacol. 2006 Oct;20(5):429-47 [16968414] Am J Respir Crit Care Med. 2009 Jan 15;179(2):138-50 [18931336] J Exp Med. 2003 Aug 4;198(3):411-21 [12900517] Am J Respir Cell Mol Biol. 2003 Oct;29(4):427-31 [14500253] Am J Pathol. 2004 Jan;164(1):263-71 [14695339] Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12731-6 [10535991] Biochem Pharmacol. 2006 Nov 30;72(11):1516-28 [16987499] COPD. 2004;1(2):255-77 [17136992] Clin Exp Allergy. 2006 Dec;36(12):1494-504 [17177672] Cancer Biomark. 2005;1(2-3):201-5 [17192041] Annu Rev Pharmacol Toxicol. 2007;47:89-116 [16968214] Am J Respir Crit Care Med. 2007 Apr 15;175(8):829-39 [17255564] Immunology. 2007 May;121(1):71-81 [17425601] Clin Pharmacol Ther. 2007 May;81(5):713-8 [17329993] Hum Mol Genet. 2007 May 15;16(10):1188-200 [17409198] J Clin Immunol. 2007 May;27(3):275-83 [17510806] Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1276-82 [17413033] Am J Respir Cell Mol Biol. 2007 Jul;37(1):3-8 [17413030] Genes Dev. 2007 Aug 1;21(15):1895-908 [17652179] Curr Mol Med. 2007 Sep;7(6):532-40 [17896990] Front Biosci. 2008;13:1813-26 [17981670] Am J Physiol Lung Cell Mol Physiol. 2008 May;294(5):L891-901 [18162602] Mol Cell. 1999 Oct;4(4):585-95 [10549290] Mol Cell. 1999 Oct;4(4):597-609 [10549291] J Immunol. 2000 Feb 1;164(3):1364-71 [10640751] N Engl J Med. 2000 May 4;342(18):1334-49 [10793167] Bioinformatics. 2000 Jan;16(1):16-23 [10812473] Gastroenterol Clin Biol. 2000 Aug-Sep;24(8-9):719-24 [11011247] J Immunol. 2000 Dec 15;165(12):6941-8 [11120820] Nat Med. 2001 Jan;7(1):53-8 [11135616] J Mol Med (Berl). 2001;79(1):30-47 [11327101] Toxicol Appl Pharmacol. 2001 Jun 15;173(3):154-60 [11437637] J Mol Endocrinol. 2001 Aug;27(1):1-9 [11463572] Am J Respir Crit Care Med. 2001 Oct 15;164(8 Pt 1):1487-94 [11704601] Am J Respir Cell Mol Biol. 2002 Jan;26(1):42-51 [11751202] Am J Respir Cell Mol Biol. 2002 Feb;26(2):175-82 [11804867] Mol Pharmacol. 2002 May;61(5):997-1007 [11961117] J Biol Chem. 2002 May 3;277(18):15703-11 [11867619] J Immunol. 2002 Aug 1;169(3):1228-35 [12133943] J Immunol. 2003 Mar 1;170(5):2663-9 [12594295] Gastroenterology. 2003 May;124(5):1315-24 [12730872] Int J Obes Relat Metab Disord. 2003 Dec;27 Suppl 3:S17-21 [14704738] J Biol Chem. 2004 Mar 12;279(11):10677-84 [14688267] Circ Res. 2004 Mar 19;94(5):609-16 [14752028] Cancer Res. 2004 May 15;64(10):3701-13 [15150131] Int Arch Allergy Immunol. 2004 Jun;134 Suppl 1:30-6 [15166481] FASEB J. 2004 Aug;18(11):1258-60 [15208274] Eur Respir J. 2004 Jul;24(1):18-23 [15293600] Mol Endocrinol. 2004 Oct;18(10):2363-77 [15231871] Biochem Biophys Res Commun. 1997 Jul 18;236(2):313-22 [9240432] Nature. 1998 Jan 1;391(6662):79-82 [9422508] Cell. 1998 Apr 17;93(2):229-40 [9568715] Cell. 1998 Apr 17;93(2):241-52 [9568716] J Biol Chem. 1998 Oct 2;273(40):25573-80 [9748221] J Clin Invest. 1999 Aug;104(4):383-9 [10449430] J Clin Invest. 2004 Nov;114(9):1248-59 [15520857] Blood. 2004 Nov 15;104(10):3276-84 [15265789] Free Radic Biol Med. 2005 Feb 1;38(3):325-43 [15629862] Eur Respir J. 2005 Feb;25(2):225-34 [15684285] Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1146-53 [15734787] Am J Respir Crit Care Med. 2005 Jun 1;171(11):1260-6 [15750045] FASEB J. 2005 Jun;19(8):1033-5 [15788448] Cancer Res. 2005 Jun 1;65(11):4769-74 [15930296] Mol Immunol. 2005 Jul;42(11):1303-10 [15950726] Comment In: Am J Respir Crit Care Med. 2010 Jul 15;182(2):134-5 [20634499] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1164/rccm.200907-1047OC ER - TY - JOUR T1 - Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor. AN - 733344241; 20346920 AB - Multivalent dendrimeric conjugates of GPCR ligands may have increased potency or selectivity in comparison to monomeric ligands, a phenomenon that was tested in a model of cytoprotection in mouse HL-1 cardiomyocytes. Quantitative RT-PCR indicated high expression levels of endogenous A(1) and A(2A) adenosine receptors (ARs), but not of A(2B) and A(3)ARs. Activation of the heterologously expressed human A(3)AR in HL-1 cells by AR agonists significantly attenuated cell damage following 4h exposure to H(2)O(2) (750 microM) but not in untransfected cells. The A(3) agonist IB-MECA (EC(50) 3.8 microM) and the non-selective agonist NECA (EC(50) 3.9 microM) protected A(3) AR-transfected cells against H(2)O(2) in a concentration-dependent manner, as determined by lactate dehydrogenase release. A generation 5.5 PAMAM (polyamidoamine) dendrimeric conjugate of a N(6)-chain-functionalized adenosine agonist was synthesized and its mass indicated an average of 60 amide-linked nucleoside moieties out of 256 theoretical attachment sites. It non-selectively activated the A(3)AR to inhibit forskolin-stimulated cAMP formation (IC(50) 66nM) and, similarly, protected A(3)-transfected HL-1 cells from apoptosis-inducing H(2)O(2) with greater potency (IC(50) 35nM) than monomeric nucleosides. Thus, a PAMAM conjugate retained AR binding affinity and displayed greatly enhanced cardioprotective potency. Published by Elsevier Inc. JF - Biochemical pharmacology AU - Keene, Athena M AU - Balasubramanian, Ramachandran AU - Lloyd, John AU - Shainberg, Asher AU - Jacobson, Kenneth A AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0810, USA. Y1 - 2010/07/15/ PY - 2010 DA - 2010 Jul 15 SP - 188 EP - 196 VL - 80 IS - 2 KW - Dendrimers KW - 0 KW - Oxidants KW - PAMAM Starburst KW - Receptors, Purinergic P1 KW - N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine KW - 152918-18-8 KW - Adenosine-5'-(N-ethylcarboxamide) KW - 35920-39-9 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Adenosine KW - K72T3FS567 KW - Index Medicus KW - Animals KW - Oxidants -- pharmacology KW - Cricetulus KW - Humans KW - Hydrogen Peroxide -- pharmacology KW - Mice KW - Cytoprotection -- drug effects KW - Cell Death -- drug effects KW - Transfection KW - Cells, Cultured KW - Protein Binding -- drug effects KW - CHO Cells KW - Gene Expression Regulation -- drug effects KW - Cytoprotection -- physiology KW - Cricetinae KW - Receptors, Purinergic P1 -- genetics KW - Myocytes, Cardiac -- drug effects KW - Adenosine -- pharmacology KW - Adenosine-5'-(N-ethylcarboxamide) -- pharmacology KW - Adenosine -- analogs & derivatives KW - Dendrimers -- pharmacology KW - Receptors, Purinergic P1 -- metabolism KW - Myocytes, Cardiac -- pathology KW - Myocytes, Cardiac -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733344241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Multivalent+dendrimeric+and+monomeric+adenosine+agonists+attenuate+cell+death+in+HL-1+mouse+cardiomyocytes+expressing+the+A%283%29+receptor.&rft.au=Keene%2C+Athena+M%3BBalasubramanian%2C+Ramachandran%3BLloyd%2C+John%3BShainberg%2C+Asher%3BJacobson%2C+Kenneth+A&rft.aulast=Keene&rft.aufirst=Athena&rft.date=2010-07-15&rft.volume=80&rft.issue=2&rft.spage=188&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=1873-2968&rft_id=info:doi/10.1016%2Fj.bcp.2010.03.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-26 N1 - Date created - 2010-05-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: FASEB J. 2000 Jul;14(10):1423-31 [10877835] Circ Res. 2001 Mar 16;88(5):520-8 [11249876] Biochem Cell Biol. 2002;80(5):655-65 [12440705] Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H823-9 [14766671] J Pharmacol Exp Ther. 2004 Sep;310(3):1190-8 [15131243] Neuroscience. 1995 Aug;67(4):921-32 [7675214] Am J Physiol. 1997 Jul;273(1 Pt 2):H501-5 [9249524] Neuropharmacology. 1997 Sep;36(9):1157-65 [9364471] Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2979-84 [9501201] J Histochem Cytochem. 1999 Sep;47(9):1179-88 [10449539] J Med Chem. 2005 Jul 28;48(15):4910-8 [16033270] J Mol Cell Cardiol. 2005 Sep;39(3):429-42 [16005018] Nat Biotechnol. 2005 Dec;23(12):1517-26 [16333296] Adv Drug Deliv Rev. 2005 Dec 14;57(15):2271-86 [16290152] Nat Rev Drug Discov. 2006 Mar;5(3):247-64 [16518376] J Mol Cell Cardiol. 2006 Sep;41(3):555-62 [16876820] J Pharmacol Exp Ther. 2006 Dec;319(3):1200-10 [16985166] J Neurosci Res. 2006 Dec;84(8):1848-55 [17016854] Cardiovasc Drug Rev. 2006 Fall-Winter;24(3-4):227-38 [17214599] J Rheumatol. 2007 Jan;34(1):20-6 [17216675] Pharmacol Ther. 2007 May;114(2):208-21 [17408751] Expert Opin Investig Drugs. 2007 Oct;16(10):1601-13 [17922624] Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3685-91 [17921328] J Rheumatol. 2008 Jan;35(1):41-8 [18050382] Bioconjug Chem. 2008 Feb;19(2):406-11 [18176997] Gene Ther. 2008 Mar;15(6):415-23 [18004403] Int J Oncol. 2008 Aug;33(2):287-95 [18636149] Anesthesiology. 2008 Aug;109(2):269-78 [18648236] Bioorg Med Chem Lett. 2008 Aug 1;18(15):4312-5 [18639453] Bioconjug Chem. 2008 Aug;19(8):1660-72 [18610944] FEBS Lett. 2008 Sep 3;582(20):2979-84 [18675812] Crit Care. 2008;12(5):226 [18828873] Basic Res Cardiol. 2009 Mar;104(2):157-67 [19242639] Handb Exp Pharmacol. 2009;(193):123-59 [19639281] Bioconjug Chem. 2009 Oct 21;20(10):1816-35 [19405524] Bioconjug Chem. 2009 Aug 19;20(8):1650-9 [19572637] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bcp.2010.03.020 ER - TY - JOUR T1 - Neuronal overexpression of cyclooxygenase-2 does not alter the neuroinflammatory response during brain innate immune activation AN - 754870354; 13215147 AB - Neuroinflammation is a critical component in the progression of several neurological and neurodegenerative diseases and cyclooxygenases (COX)-1 and -2 are key regulators of innate immune responses. We recently demonstrated that COX-1 deletion attenuates, whereas COX-2 deletion enhances, the neuroinflammatory response, blood-brain barrier permeability and leukocyte recruitment during lipopolysaccharide (LPS)-induced innate immune activation. Here, we used transgenic mice, which overexpressed human COX-2 via neuron-specific Thy-1 promoter (TgCOX-2), causing elevated prostaglandins (PGs) levels. We tested whether neuronal COX-2 overexpression affects the glial response to a single intracerebroventricular injection of LPS, which produces a robust neuroinflammatory reaction. Relative to non-transgenic controls (NTg), 7 month-old TgCOX-2 did not show any basal neuroinflammation, as assessed by gene expression of markers of inflammation and oxidative stress, neuronal damage, as assessed by Fluoro-JadeB staining, or systemic inflammation, as assessed by plasma levels of IL-1b and corticosterone. Twenty-four hours after LPS injection, all mice showed increased microglial activation, as indicated by Iba1 immunostaining, neuronal damage, mRNA expression of cytokines (TNF-a, IL-6), reactive oxygen expressing enzymes (iNOS and NADPH oxidase subunits), endogenous COX-2, cPLA sub(2) and mPGES-1, and hippocampal and cortical IL-1b levels. However, the increases were similar in TgCOX-2 and NTg. In NTg, LPS increased brain PGE sub(2) to the levels observed in TgCOX-2. These results suggest that PGs derived from neuronal COX-2 do not play a role in the neuroinflammatory response to acute activation of brain innate immunity. This is likely due to the direct effect of LPS on glial rather than neuronal cells. JF - Neuroscience Letters AU - Aid, Saba AU - Parikh, Nishant AU - Palumbo, Sara AU - Bosetti, Francesca AD - Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, NIH, Bethesda, MD 20892, United States, frances@mail.nih.gov Y1 - 2010/07/12/ PY - 2010 DA - 2010 Jul 12 SP - 113 EP - 118 PB - Elsevier Science Ltd., The Boulevard Kidlington Oxford OX5 1GB UK VL - 478 IS - 3 SN - 0304-3940, 0304-3940 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; CSA Neurosciences Abstracts KW - Cyclooxygenase-2 KW - Microglia KW - Neuron KW - Neuroinflammation KW - Cytokines KW - Lipopolysaccharide KW - Interleukin 6 KW - Hippocampus KW - Blood-brain barrier KW - Interleukin 1 KW - Gene expression KW - Leukocyte migration KW - Corticosterone KW - Promoters KW - Nervous system KW - Oxidative stress KW - Lipopolysaccharides KW - NAD(P)H oxidase KW - Neuronal-glial interactions KW - Prostaglandin-E synthase KW - Brain KW - Membrane permeability KW - Enzymes KW - Prostaglandin E2 KW - Immunity KW - Tumor necrosis factor-a KW - Transgenic mice KW - Inflammation KW - Cyclooxygenase-1 KW - Nitric-oxide synthase KW - Oxygen KW - Neurodegenerative diseases KW - Plasma levels KW - Immune response KW - W 30925:Genetic Engineering KW - F 06910:Microorganisms & Parasites KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754870354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+Letters&rft.atitle=Neuronal+overexpression+of+cyclooxygenase-2+does+not+alter+the+neuroinflammatory+response+during+brain+innate+immune+activation&rft.au=Aid%2C+Saba%3BParikh%2C+Nishant%3BPalumbo%2C+Sara%3BBosetti%2C+Francesca&rft.aulast=Aid&rft.aufirst=Saba&rft.date=2010-07-12&rft.volume=478&rft.issue=3&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Neuroscience+Letters&rft.issn=03043940&rft_id=info:doi/10.1016%2Fj.neulet.2010.04.076 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Blood-brain barrier; Hippocampus; Interleukin 1; Leukocyte migration; Gene expression; Promoters; Corticosterone; Nervous system; Oxidative stress; Lipopolysaccharides; NAD(P)H oxidase; Neuronal-glial interactions; Prostaglandin-E synthase; Cyclooxygenase-2; Brain; Enzymes; Membrane permeability; Immunity; Prostaglandin E2; Transgenic mice; Tumor necrosis factor-a; Cyclooxygenase-1; Inflammation; Nitric-oxide synthase; Neurodegenerative diseases; Oxygen; Plasma levels; Immune response DO - http://dx.doi.org/10.1016/j.neulet.2010.04.076 ER - TY - CPAPER T1 - The Dynamics of Obesity T2 - 2010 SIAM Annual Meeting (AN10) AN - 1312926755; 5999254 JF - 2010 SIAM Annual Meeting (AN10) AU - Chow, Carson Y1 - 2010/07/12/ PY - 2010 DA - 2010 Jul 12 KW - obesity KW - Obesity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312926755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+SIAM+Annual+Meeting+%28AN10%29&rft.atitle=The+Dynamics+of+Obesity&rft.au=Chow%2C+Carson&rft.aulast=Chow&rft.aufirst=Carson&rft.date=2010-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+SIAM+Annual+Meeting+%28AN10%29&rft.issn=&rft_id=info:doi/ L2 - http://meetings.siam.org/program.cfm?CONFCODE=AN10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Moving Innovation Forward: The Biosensors Program at NIH T2 - 2010 SIAM Annual Meeting (AN10) AN - 1312876815; 5999710 JF - 2010 SIAM Annual Meeting (AN10) AU - Peterson, Karen Y1 - 2010/07/12/ PY - 2010 DA - 2010 Jul 12 KW - Biosensors KW - innovations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312876815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+SIAM+Annual+Meeting+%28AN10%29&rft.atitle=Moving+Innovation+Forward%3A+The+Biosensors+Program+at+NIH&rft.au=Peterson%2C+Karen&rft.aulast=Peterson&rft.aufirst=Karen&rft.date=2010-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+SIAM+Annual+Meeting+%28AN10%29&rft.issn=&rft_id=info:doi/ L2 - http://meetings.siam.org/program.cfm?CONFCODE=AN10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Anthrax toxin receptor expression in specific tissues determines the susceptibility of mice to infection T2 - 2010 Gordon Research Conference on Microbial Toxins and Pathogenicity AN - 1312864987; 5979769 JF - 2010 Gordon Research Conference on Microbial Toxins and Pathogenicity AU - Leppla, Stephen Y1 - 2010/07/11/ PY - 2010 DA - 2010 Jul 11 KW - infection KW - anthrax KW - Mice KW - Toxins KW - Anthrax KW - Infection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312864987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Microbial+Toxins+and+Pathogenicity&rft.atitle=Anthrax+toxin+receptor+expression+in+specific+tissues+determines+the+susceptibility+of+mice+to+infection&rft.au=Leppla%2C+Stephen&rft.aulast=Leppla&rft.aufirst=Stephen&rft.date=2010-07-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Microbial+Toxins+and+Pathogenicity&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=micrtox LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Subversion of the Eukaryotic Host Cell by Secreted Chlamydia trachomatis is Effectors T2 - 2010 Gordon Research Conference on Microbial Toxins and Pathogenicity AN - 1312858015; 5979786 JF - 2010 Gordon Research Conference on Microbial Toxins and Pathogenicity AU - Hackstadt, Ted Y1 - 2010/07/11/ PY - 2010 DA - 2010 Jul 11 KW - Sexually-transmitted diseases KW - Chlamydia trachomatis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312858015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Microbial+Toxins+and+Pathogenicity&rft.atitle=Subversion+of+the+Eukaryotic+Host+Cell+by+Secreted+Chlamydia+trachomatis+is+Effectors&rft.au=Hackstadt%2C+Ted&rft.aulast=Hackstadt&rft.aufirst=Ted&rft.date=2010-07-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Microbial+Toxins+and+Pathogenicity&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=micrtox LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Paxillin Phosphorylation Is a Local Regulator of Mechanotransduction Within Individual Focal Adhesions T2 - 2010 Gordon Research Conference on Signaling by Cell Adhesion Receptors AN - 1312856472; 5981313 JF - 2010 Gordon Research Conference on Signaling by Cell Adhesion Receptors AU - Plotnikov, Sergey Y1 - 2010/07/11/ PY - 2010 DA - 2010 Jul 11 KW - adhesion KW - Mechanotransduction KW - Phosphorylation KW - paxillin KW - Adhesion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312856472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Signaling+by+Cell+Adhesion+Receptors&rft.atitle=Paxillin+Phosphorylation+Is+a+Local+Regulator+of+Mechanotransduction+Within+Individual+Focal+Adhesions&rft.au=Plotnikov%2C+Sergey&rft.aulast=Plotnikov&rft.aufirst=Sergey&rft.date=2010-07-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Signaling+by+Cell+Adhesion+Receptors&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=sigadhes LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Pore-opening mechanism in trimeric P2X receptor channels T2 - 2010 Gordon Research Conference on Ion Channels AN - 1312850255; 5979941 JF - 2010 Gordon Research Conference on Ion Channels AU - Li, Mufeng Y1 - 2010/07/11/ PY - 2010 DA - 2010 Jul 11 KW - Channels KW - Purine P2X receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312850255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Ion+Channels&rft.atitle=Pore-opening+mechanism+in+trimeric+P2X+receptor+channels&rft.au=Li%2C+Mufeng&rft.aulast=Li&rft.aufirst=Mufeng&rft.date=2010-07-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Ion+Channels&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=ionchan LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Mouse models of misregulation of human iron metabolism T2 - 2010 Gordon Research Conference on Mitochondria and Chloroplasts AN - 1312848466; 5979854 JF - 2010 Gordon Research Conference on Mitochondria and Chloroplasts AU - Rouault, Tracey Y1 - 2010/07/11/ PY - 2010 DA - 2010 Jul 11 KW - Metabolism KW - Iron KW - Animal models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312848466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Mitochondria+and+Chloroplasts&rft.atitle=Mouse+models+of+misregulation+of+human+iron+metabolism&rft.au=Rouault%2C+Tracey&rft.aulast=Rouault&rft.aufirst=Tracey&rft.date=2010-07-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Mitochondria+and+Chloroplasts&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=mitochon LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Research on early-stage carcinogenesis: are we approaching paradigm instability? AN - 733654956; 20547997 JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Baker, Stuart G AU - Cappuccio, Antonio AU - Potter, John D AD - Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA. Y1 - 2010/07/10/ PY - 2010 DA - 2010 Jul 10 SP - 3215 EP - 3218 VL - 28 IS - 20 KW - Index Medicus KW - Humans KW - Organ Specificity KW - Mutation KW - Neoplasms -- pathology KW - Models, Biological KW - Neoplasms -- genetics KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733654956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Research+on+early-stage+carcinogenesis%3A+are+we+approaching+paradigm+instability%3F&rft.au=Baker%2C+Stuart+G%3BCappuccio%2C+Antonio%3BPotter%2C+John+D&rft.aulast=Baker&rft.aufirst=Stuart&rft.date=2010-07-10&rft.volume=28&rft.issue=20&rft.spage=3215&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2010.28.5460 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-20 N1 - Date created - 2010-07-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2001 Nov 1;414(6859):105-11 [11689955] Annu Rev Genomics Hum Genet. 2009;10:1-18 [19715438] J Cell Sci. 2004 Mar 15;117(Pt 8):1495-502 [14996910] Bioessays. 2004 Oct;26(10):1097-107 [15382143] Dev Biol. 1970 Mar;21(3):364-82 [5436899] J Natl Cancer Inst. 1973 Oct;51(4):1275-85 [4583375] Nature. 1981 Mar 19;290(5803):261-4 [7207618] Nature. 1983 Jan 6;301(5895):89-92 [6185846] Nature. 1985 Dec 12-18;318(6046):533-8 [3906410] Cell. 1995 Apr 21;81(2):197-205 [7537636] Nature. 1963 Jul 6;199:79-80 [14047954] Cell Oncol. 2005;27(5-6):293-318 [16373963] Nature. 2007 Mar 8;446(7132):145-6 [17344839] Nature. 2007 Mar 8;446(7132):153-8 [17344846] Cancer Cell. 2007 Mar;11(3):259-73 [17349583] Int J Epidemiol. 2007 Feb;36(1):246-7 [17169945] Nat Rev Cancer. 2007 Jun;7(6):464-74 [17522715] BMC Cancer. 2007;7:151 [17683619] N Engl J Med. 2008 Jan 31;358(5):502-11 [18234754] N Engl J Med. 2008 Mar 13;358(11):1148-59 [18337604] Semin Cancer Biol. 2008 Oct;18(5):372-7 [18472276] Cancer Res. 2008 Sep 1;68(17):6863-72 [18757397] Cancer Metastasis Rev. 2009 Jun;28(1-2):167-76 [19160017] BMC Cancer. 2009;9:89 [19309499] Nature. 2009 Apr 9;458(7239):719-24 [19360079] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 [12629218] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1200/JCO.2010.28.5460 ER - TY - CPAPER T1 - Activatable Strategies for Fluorescent Probe Design in the Molecular Imaging T2 - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AN - 1312879976; 5984607 JF - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AU - Kobayashi, H Y1 - 2010/07/10/ PY - 2010 DA - 2010 Jul 10 KW - Fluorescent indicators KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312879976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.atitle=Activatable+Strategies+for+Fluorescent+Probe+Design+in+the+Molecular+Imaging&rft.au=Kobayashi%2C+H&rft.aulast=Kobayashi&rft.aufirst=H&rft.date=2010-07-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.controlledrelease.org/meeting/2010/program/pdfs/Programbook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - NCL Data: Trends in Biocompatibility and Toxicity T2 - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AN - 1312869615; 5985112 JF - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AU - McNeil, S AU - Stern, S Y1 - 2010/07/10/ PY - 2010 DA - 2010 Jul 10 KW - Toxicity KW - biocompatibility KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312869615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.atitle=NCL+Data%3A+Trends+in+Biocompatibility+and+Toxicity&rft.au=McNeil%2C+S%3BStern%2C+S&rft.aulast=McNeil&rft.aufirst=S&rft.date=2010-07-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.controlledrelease.org/meeting/2010/program/pdfs/Programbook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Topical microbicides to prevent the transmission of HIV: Formulation and delivery challenges and opportunities T2 - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AN - 1312868761; 5984644 JF - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AU - Turpin, J Y1 - 2010/07/10/ PY - 2010 DA - 2010 Jul 10 KW - disease transmission KW - Disease transmission KW - microbicides KW - Human immunodeficiency virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312868761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.atitle=Topical+microbicides+to+prevent+the+transmission+of+HIV%3A+Formulation+and+delivery+challenges+and+opportunities&rft.au=Turpin%2C+J&rft.aulast=Turpin&rft.aufirst=J&rft.date=2010-07-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.controlledrelease.org/meeting/2010/program/pdfs/Programbook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Polyp-Specific Contrast Agents for Virtual Colonoscopy: Rationale and Early Developments T2 - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AN - 1312842914; 5984608 JF - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AU - Summers, R AU - Roney, C AU - Xie, J AU - Xu, B AU - Griffiths, G Y1 - 2010/07/10/ PY - 2010 DA - 2010 Jul 10 KW - Colon KW - Contrast media UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312842914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.atitle=Polyp-Specific+Contrast+Agents+for+Virtual+Colonoscopy%3A+Rationale+and+Early+Developments&rft.au=Summers%2C+R%3BRoney%2C+C%3BXie%2C+J%3BXu%2C+B%3BGriffiths%2C+G&rft.aulast=Summers&rft.aufirst=R&rft.date=2010-07-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.controlledrelease.org/meeting/2010/program/pdfs/Programbook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Machine Learning for Identifying Abbreviation Definitions T2 - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AN - 41681690; 9946699; 5984376 JF - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AU - Yeganova, Lana AU - Comeau, Donald AU - Wilbur, W Y1 - 2010/07/09/ PY - 2010 DA - 2010 Jul 09 KW - Learning algorithms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41681690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.atitle=Machine+Learning+for+Identifying+Abbreviation+Definitions&rft.au=Yeganova%2C+Lana%3BComeau%2C+Donald%3BWilbur%2C+W&rft.aulast=Yeganova&rft.aufirst=Lana&rft.date=2010-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismb2010-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-03 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Roles of Signal Transducer and Activator of Transcription in Tuning Epigenetic Modification and Transcription during Helper T Cell Differentiation T2 - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AN - 1312879118; 5984095 JF - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AU - Vahedi, Golnaz AU - Wei, Lai AU - Sun, Hongwei AU - Takahashi, Hayato AU - Gutierrez-Cruz, Gustavo AU - O'Shea, John AU - Kanno, Yuka Y1 - 2010/07/09/ PY - 2010 DA - 2010 Jul 09 KW - cell differentiation KW - transducers KW - Transcription KW - Differentiation KW - Lymphocytes T KW - epigenetics KW - Cell differentiation KW - Transducers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312879118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.atitle=Roles+of+Signal+Transducer+and+Activator+of+Transcription+in+Tuning+Epigenetic+Modification+and+Transcription+during+Helper+T+Cell+Differentiation&rft.au=Vahedi%2C+Golnaz%3BWei%2C+Lai%3BSun%2C+Hongwei%3BTakahashi%2C+Hayato%3BGutierrez-Cruz%2C+Gustavo%3BO%27Shea%2C+John%3BKanno%2C+Yuka&rft.aulast=Vahedi&rft.aufirst=Golnaz&rft.date=2010-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismb2010-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - GOPHER: A Web-based Tool for Biological Network Analysis Using Gene Expression T2 - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AN - 1312878749; 5984326 JF - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AU - Johnson, Kory AU - Yavatkar, Amar AU - Fann, Yang Y1 - 2010/07/09/ PY - 2010 DA - 2010 Jul 09 KW - Gene expression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312878749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.atitle=GOPHER%3A+A+Web-based+Tool+for+Biological+Network+Analysis+Using+Gene+Expression&rft.au=Johnson%2C+Kory%3BYavatkar%2C+Amar%3BFann%2C+Yang&rft.aulast=Johnson&rft.aufirst=Kory&rft.date=2010-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismb2010-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Evolutionary classification and understanding the catalytic diversity of the Tautomerase Superfamily T2 - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AN - 1312877015; 5984185 JF - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AU - Saraswathi, Abhiman AU - Aravind, L Y1 - 2010/07/09/ PY - 2010 DA - 2010 Jul 09 KW - classification KW - Classification KW - Evolution KW - Species diversity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312877015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.atitle=Evolutionary+classification+and+understanding+the+catalytic+diversity+of+the+Tautomerase+Superfamily&rft.au=Saraswathi%2C+Abhiman%3BAravind%2C+L&rft.aulast=Saraswathi&rft.aufirst=Abhiman&rft.date=2010-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismb2010-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Detection of Fusion Genes in mRNA-Seq Data T2 - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AN - 1312876681; 5984170 JF - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AU - Bilke, Sven AU - Walker, Bob AU - Pineda, Marbin AU - Francis, Princy AU - Abaan, Ogan AU - Paul, Meltzer Y1 - 2010/07/09/ PY - 2010 DA - 2010 Jul 09 KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312876681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.atitle=Detection+of+Fusion+Genes+in+mRNA-Seq+Data&rft.au=Bilke%2C+Sven%3BWalker%2C+Bob%3BPineda%2C+Marbin%3BFrancis%2C+Princy%3BAbaan%2C+Ogan%3BPaul%2C+Meltzer&rft.aulast=Bilke&rft.aufirst=Sven&rft.date=2010-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismb2010-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Application and Development of Structural Bioinformatics Methods for Rational Vaccine Design T2 - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AN - 1312875913; 5984266 JF - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AU - Georgiev, Ivelin AU - Zhu, Jiang AU - Shapiro, Lawrence AU - Kwong, Peter Y1 - 2010/07/09/ PY - 2010 DA - 2010 Jul 09 KW - vaccines KW - bioinformatics KW - Vaccines KW - Bioinformatics KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312875913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.atitle=Application+and+Development+of+Structural+Bioinformatics+Methods+for+Rational+Vaccine+Design&rft.au=Georgiev%2C+Ivelin%3BZhu%2C+Jiang%3BShapiro%2C+Lawrence%3BKwong%2C+Peter&rft.aulast=Georgiev&rft.aufirst=Ivelin&rft.date=2010-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismb2010-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Inferring protein-protein interactions based on conservation of interfaces in structural homologs T2 - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AN - 1312875199; 5983768 JF - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AU - Tyagi, Manoj AU - Thangudu, Ratna AU - Shoemaker, Benjamin AU - Bryant, Stephen AU - Madej, Thomas AU - Panchenko, Anna Y1 - 2010/07/09/ PY - 2010 DA - 2010 Jul 09 KW - Conservation KW - Protein interaction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312875199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.atitle=Inferring+protein-protein+interactions+based+on+conservation+of+interfaces+in+structural+homologs&rft.au=Tyagi%2C+Manoj%3BThangudu%2C+Ratna%3BShoemaker%2C+Benjamin%3BBryant%2C+Stephen%3BMadej%2C+Thomas%3BPanchenko%2C+Anna&rft.aulast=Tyagi&rft.aufirst=Manoj&rft.date=2010-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismb2010-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Threshold Average Precision (TAP-k): A Retrieval E?cacy Measure for Bioinformatics T2 - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AN - 1312862289; 5984165 JF - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AU - Carroll, Hyrum AU - Kann, Maricel AU - Sheetlin, Sergey AU - Spouge, John Y1 - 2010/07/09/ PY - 2010 DA - 2010 Jul 09 KW - bioinformatics KW - Bioinformatics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312862289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.atitle=Threshold+Average+Precision+%28TAP-k%29%3A+A+Retrieval+E%3Fcacy+Measure+for+Bioinformatics&rft.au=Carroll%2C+Hyrum%3BKann%2C+Maricel%3BSheetlin%2C+Sergey%3BSpouge%2C+John&rft.aulast=Carroll&rft.aufirst=Hyrum&rft.date=2010-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismb2010-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - cis-Decoder: A web-based tool for searching a genome-wide conserved sequence cluster database to identify functionally related cis-regulatory elements T2 - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AN - 1312859631; 5983826 JF - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AU - Yavatkar, Amarendra AU - Tyson, Leonard AU - Brody, Thomas AU - Fann, Yang AU - Odenwald, Ward Y1 - 2010/07/09/ PY - 2010 DA - 2010 Jul 09 KW - Conserved sequence KW - Databases KW - Phylogeny UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312859631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.atitle=cis-Decoder%3A+A+web-based+tool+for+searching+a+genome-wide+conserved+sequence+cluster+database+to+identify+functionally+related+cis-regulatory+elements&rft.au=Yavatkar%2C+Amarendra%3BTyson%2C+Leonard%3BBrody%2C+Thomas%3BFann%2C+Yang%3BOdenwald%2C+Ward&rft.aulast=Yavatkar&rft.aufirst=Amarendra&rft.date=2010-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismb2010-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Protein domain assignment from the recurrence of locally similar structures T2 - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AN - 1312858910; 5984197 JF - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AU - Tai, Chin-Hsien AU - Sam, Vichetra AU - Gibrat, Jean-Francois AU - Garnier, Jean AU - Munson, Peter AU - Lee, Byungkook Y1 - 2010/07/09/ PY - 2010 DA - 2010 Jul 09 KW - Proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312858910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.atitle=Protein+domain+assignment+from+the+recurrence+of+locally+similar+structures&rft.au=Tai%2C+Chin-Hsien%3BSam%2C+Vichetra%3BGibrat%2C+Jean-Francois%3BGarnier%2C+Jean%3BMunson%2C+Peter%3BLee%2C+Byungkook&rft.aulast=Tai&rft.aufirst=Chin-Hsien&rft.date=2010-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismb2010-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Genome wide map of meiotic double stranded break hotspots in the mouse T2 - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AN - 1312856604; 5983839 JF - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AU - Brick, Kevin AU - Gregoretti, Ivan AU - Khil, Pavel AU - Smagulova, Fatima AU - Petukhova, Galina AU - Camerini-Otero, Dan Y1 - 2010/07/09/ PY - 2010 DA - 2010 Jul 09 KW - hot spots KW - Genomes KW - Meiosis KW - Hot spots UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312856604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.atitle=Genome+wide+map+of+meiotic+double+stranded+break+hotspots+in+the+mouse&rft.au=Brick%2C+Kevin%3BGregoretti%2C+Ivan%3BKhil%2C+Pavel%3BSmagulova%2C+Fatima%3BPetukhova%2C+Galina%3BCamerini-Otero%2C+Dan&rft.aulast=Brick&rft.aufirst=Kevin&rft.date=2010-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismb2010-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Cracking the genetic code of heart regulatory elements T2 - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AN - 1312850199; 5983445 JF - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AU - Ovcharenko, Ivan AU - Nobrega, Marcelo Y1 - 2010/07/09/ PY - 2010 DA - 2010 Jul 09 KW - Regulatory sequences KW - Genetic code KW - Heart UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312850199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.atitle=Cracking+the+genetic+code+of+heart+regulatory+elements&rft.au=Ovcharenko%2C+Ivan%3BNobrega%2C+Marcelo&rft.aulast=Ovcharenko&rft.aufirst=Ivan&rft.date=2010-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismb2010-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Towards Decoding The Regulatory Code of The Human Forebrain T2 - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AN - 1312847563; 5984108 JF - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AU - Girgis, Hani AU - Visel, Axel AU - Rubenstein, John AU - Ovcharenko, Ivan Y1 - 2010/07/09/ PY - 2010 DA - 2010 Jul 09 KW - Forebrain UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312847563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.atitle=Towards+Decoding+The+Regulatory+Code+of+The+Human+Forebrain&rft.au=Girgis%2C+Hani%3BVisel%2C+Axel%3BRubenstein%2C+John%3BOvcharenko%2C+Ivan&rft.aulast=Girgis&rft.aufirst=Hani&rft.date=2010-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismb2010-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Detecting internally symmetric protein structures T2 - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AN - 1312846048; 5983938 JF - 18th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2010) AU - Lee, Byungkook AU - Kim, Changhoon AU - Basner, Jodi Y1 - 2010/07/09/ PY - 2010 DA - 2010 Jul 09 KW - Protein structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312846048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.atitle=Detecting+internally+symmetric+protein+structures&rft.au=Lee%2C+Byungkook%3BKim%2C+Changhoon%3BBasner%2C+Jodi&rft.aulast=Lee&rft.aufirst=Byungkook&rft.date=2010-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismb2010-program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Progress in CW & Time Domain Functional EPR Imaging: Recent applications In Tumor Oximetry and correlation with MRI T2 - 2010 World Wide Magnetic Resonance Conference: Joint EUROMAR 2010 and 17th ISMAR Conference (WWMR 2010) AN - 866037040; 5972485 JF - 2010 World Wide Magnetic Resonance Conference: Joint EUROMAR 2010 and 17th ISMAR Conference (WWMR 2010) AU - Subramanian, Sankaran AU - Devasahayam, Nallathamby AU - Matsumoto, Shingo AU - Saito, Keita AU - Krishna, Murali Y1 - 2010/07/04/ PY - 2010 DA - 2010 Jul 04 KW - tumors KW - Magnetic resonance imaging KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866037040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+World+Wide+Magnetic+Resonance+Conference%3A+Joint+EUROMAR+2010+and+17th+ISMAR+Conference+%28WWMR+2010%29&rft.atitle=Progress+in+CW+%26amp%3B+Time+Domain+Functional+EPR+Imaging%3A+Recent+applications+In+Tumor+Oximetry+and+correlation+with+MRI&rft.au=Subramanian%2C+Sankaran%3BDevasahayam%2C+Nallathamby%3BMatsumoto%2C+Shingo%3BSaito%2C+Keita%3BKrishna%2C+Murali&rft.aulast=Subramanian&rft.aufirst=Sankaran&rft.date=2010-07-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+World+Wide+Magnetic+Resonance+Conference%3A+Joint+EUROMAR+2010+and+17th+ISMAR+Conference+%28WWMR+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cerm.unifi.it/wwmr2010/files/Book.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Multi-component Protein: Protein Complexes: The Impact of Long-range Restraints Derived from PRE, PCS, RDCs, Intermolecular NOE, and SAXS Data T2 - 2010 World Wide Magnetic Resonance Conference: Joint EUROMAR 2010 and 17th ISMAR Conference (WWMR 2010) AN - 866034629; 5971995 JF - 2010 World Wide Magnetic Resonance Conference: Joint EUROMAR 2010 and 17th ISMAR Conference (WWMR 2010) AU - Byrd, R AU - Das, Ranabir AU - Chen, Yinghua AU - Li, Jess AU - King, Aaren AU - Mariano, Jennifer AU - Weissmanb, Allan AU - Liang, Yu-He AU - Ji, Xinhua AU - Haussinger, Daniel Y1 - 2010/07/04/ PY - 2010 DA - 2010 Jul 04 KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866034629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+World+Wide+Magnetic+Resonance+Conference%3A+Joint+EUROMAR+2010+and+17th+ISMAR+Conference+%28WWMR+2010%29&rft.atitle=Multi-component+Protein%3A+Protein+Complexes%3A+The+Impact+of+Long-range+Restraints+Derived+from+PRE%2C+PCS%2C+RDCs%2C+Intermolecular+NOE%2C+and+SAXS+Data&rft.au=Byrd%2C+R%3BDas%2C+Ranabir%3BChen%2C+Yinghua%3BLi%2C+Jess%3BKing%2C+Aaren%3BMariano%2C+Jennifer%3BWeissmanb%2C+Allan%3BLiang%2C+Yu-He%3BJi%2C+Xinhua%3BHaussinger%2C+Daniel&rft.aulast=Byrd&rft.aufirst=R&rft.date=2010-07-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+World+Wide+Magnetic+Resonance+Conference%3A+Joint+EUROMAR+2010+and+17th+ISMAR+Conference+%28WWMR+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cerm.unifi.it/wwmr2010/files/Book.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Structure and dynamics of the HIV viral envelope gp41 fusion domain T2 - 2010 World Wide Magnetic Resonance Conference: Joint EUROMAR 2010 and 17th ISMAR Conference (WWMR 2010) AN - 866034403; 5972297 JF - 2010 World Wide Magnetic Resonance Conference: Joint EUROMAR 2010 and 17th ISMAR Conference (WWMR 2010) AU - Lakomek, Nils-Alexander AU - Bax, Ad AU - Kaufman, Joshua AU - Stahl, Steven AU - Wingfield, Paul Y1 - 2010/07/04/ PY - 2010 DA - 2010 Jul 04 KW - Human immunodeficiency virus KW - Envelopes KW - glycoprotein gp41 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866034403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+World+Wide+Magnetic+Resonance+Conference%3A+Joint+EUROMAR+2010+and+17th+ISMAR+Conference+%28WWMR+2010%29&rft.atitle=Structure+and+dynamics+of+the+HIV+viral+envelope+gp41+fusion+domain&rft.au=Lakomek%2C+Nils-Alexander%3BBax%2C+Ad%3BKaufman%2C+Joshua%3BStahl%2C+Steven%3BWingfield%2C+Paul&rft.aulast=Lakomek&rft.aufirst=Nils-Alexander&rft.date=2010-07-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+World+Wide+Magnetic+Resonance+Conference%3A+Joint+EUROMAR+2010+and+17th+ISMAR+Conference+%28WWMR+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cerm.unifi.it/wwmr2010/files/Book.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Hybrid structure determination methods, paramagnetic relaxation and differential relaxation T2 - 2010 World Wide Magnetic Resonance Conference: Joint EUROMAR 2010 and 17th ISMAR Conference (WWMR 2010) AN - 866034030; 5972004 JF - 2010 World Wide Magnetic Resonance Conference: Joint EUROMAR 2010 and 17th ISMAR Conference (WWMR 2010) AU - Clore, G Y1 - 2010/07/04/ PY - 2010 DA - 2010 Jul 04 KW - hybrids KW - Hybrids UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866034030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+World+Wide+Magnetic+Resonance+Conference%3A+Joint+EUROMAR+2010+and+17th+ISMAR+Conference+%28WWMR+2010%29&rft.atitle=Hybrid+structure+determination+methods%2C+paramagnetic+relaxation+and+differential+relaxation&rft.au=Clore%2C+G&rft.aulast=Clore&rft.aufirst=G&rft.date=2010-07-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+World+Wide+Magnetic+Resonance+Conference%3A+Joint+EUROMAR+2010+and+17th+ISMAR+Conference+%28WWMR+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cerm.unifi.it/wwmr2010/files/Book.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - The sticky fingers of influenza visualized by modern solution NMR T2 - 2010 World Wide Magnetic Resonance Conference: Joint EUROMAR 2010 and 17th ISMAR Conference (WWMR 2010) AN - 866032446; 5971978 JF - 2010 World Wide Magnetic Resonance Conference: Joint EUROMAR 2010 and 17th ISMAR Conference (WWMR 2010) AU - Lorieau, Justin AU - Grishaev, Alex AU - Louis, John AU - Bax, Ad Y1 - 2010/07/04/ PY - 2010 DA - 2010 Jul 04 KW - N.M.R. KW - influenza KW - Finger KW - Influenza UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866032446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+World+Wide+Magnetic+Resonance+Conference%3A+Joint+EUROMAR+2010+and+17th+ISMAR+Conference+%28WWMR+2010%29&rft.atitle=The+sticky+fingers+of+influenza+visualized+by+modern+solution+NMR&rft.au=Lorieau%2C+Justin%3BGrishaev%2C+Alex%3BLouis%2C+John%3BBax%2C+Ad&rft.aulast=Lorieau&rft.aufirst=Justin&rft.date=2010-07-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+World+Wide+Magnetic+Resonance+Conference%3A+Joint+EUROMAR+2010+and+17th+ISMAR+Conference+%28WWMR+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cerm.unifi.it/wwmr2010/files/Book.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - The percentage (%) and severity of cytologic abnormalities vary by HPV genotype: a population-wide analysis T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866054891; 5968344 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Porras, Carolina AU - Hildesheim, Allan AU - Wacholder, Sholom AU - Schiffman, Mark AU - Rodriguez, Ana AU - Gonzalez, Paula AU - Herrero, Rolando AU - van Doorn, Leen-Jan AU - Quint, Wim Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Genotypes KW - Abnormalities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866054891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=The+percentage+%28%25%29+and+severity+of+cytologic+abnormalities+vary+by+HPV+genotype%3A+a+population-wide+analysis&rft.au=Porras%2C+Carolina%3BHildesheim%2C+Allan%3BWacholder%2C+Sholom%3BSchiffman%2C+Mark%3BRodriguez%2C+Ana%3BGonzalez%2C+Paula%3BHerrero%2C+Rolando%3Bvan+Doorn%2C+Leen-Jan%3BQuint%2C+Wim&rft.aulast=Porras&rft.aufirst=Carolina&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Estimated population-level burden of HPV-positive oropharynx cancers among smokers and never smokers in the United States T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866054787; 5968266 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Chaturvedi, Anil AU - Katki, Hormuzd AU - D'Souza, Gypsyamber AU - Gillison, Maura Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - USA KW - Cancer KW - Oropharynx UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866054787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Estimated+population-level+burden+of+HPV-positive+oropharynx+cancers+among+smokers+and+never+smokers+in+the+United+States&rft.au=Chaturvedi%2C+Anil%3BKatki%2C+Hormuzd%3BD%27Souza%2C+Gypsyamber%3BGillison%2C+Maura&rft.aulast=Chaturvedi&rft.aufirst=Anil&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Clinical management guidelines based on risk of cervical precancer or cancer T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866054695; 5968183 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Katki, Hormuzd AU - Schiffman, Mark AU - Solomon, Diane AU - Wacholder, Sholom AU - Castle, Philip AU - Fetterman, Barbara AU - Kinney, Walter AU - Lorey, Thomas AU - Poitras, Nancy Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Cancer KW - guidelines KW - Cervix UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866054695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Clinical+management+guidelines+based+on+risk+of+cervical+precancer+or+cancer&rft.au=Katki%2C+Hormuzd%3BSchiffman%2C+Mark%3BSolomon%2C+Diane%3BWacholder%2C+Sholom%3BCastle%2C+Philip%3BFetterman%2C+Barbara%3BKinney%2C+Walter%3BLorey%2C+Thomas%3BPoitras%2C+Nancy&rft.aulast=Katki&rft.aufirst=Hormuzd&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - HPV vaccines: Trials and results T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866053469; 5967654 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Schiller, John Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - clinical trials KW - Vaccines KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866053469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=HPV+vaccines%3A+Trials+and+results&rft.au=Schiller%2C+John&rft.aulast=Schiller&rft.aufirst=John&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/images/stories/downloads/HPV2010_FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - High Prevalence of Carcinogenic HPV Among Older Women in Nigeria, Africa: Can We Still Screen with HPV Testing? T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866052694; 5968402 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Gage, Julia AU - Wentzensen, Nicolas AU - Wacholder, Sholom AU - Schiffman, Mark AU - Ajenifuja, Olusegun AU - Akinfolarin, Adepiti AU - Burk, Robert Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Nigeria KW - Africa KW - Carcinogenicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866052694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=High+Prevalence+of+Carcinogenic+HPV+Among+Older+Women+in+Nigeria%2C+Africa%3A+Can+We+Still+Screen+with+HPV+Testing%3F&rft.au=Gage%2C+Julia%3BWentzensen%2C+Nicolas%3BWacholder%2C+Sholom%3BSchiffman%2C+Mark%3BAjenifuja%2C+Olusegun%3BAkinfolarin%2C+Adepiti%3BBurk%2C+Robert&rft.aulast=Gage&rft.aufirst=Julia&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Age-Specific Human Papillomavirus Antibody Prevalence: A Global Review T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866052682; 5968510 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Lin, Margaret AU - Ji, Jia AU - Viscidi, Raphael AU - Smith, Jennifer Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Reviews KW - Antibodies KW - Human papillomavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866052682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Age-Specific+Human+Papillomavirus+Antibody+Prevalence%3A+A+Global+Review&rft.au=Lin%2C+Margaret%3BJi%2C+Jia%3BViscidi%2C+Raphael%3BSmith%2C+Jennifer&rft.aulast=Lin&rft.aufirst=Margaret&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Seroprevalence and Determinants of Human Papillomavirus 16/18 Seropositivity among Young Women in Costa Rica T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866052656; 5968392 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Coseo, Sarah AU - Porras, Carolina AU - Schiffman, Mark AU - Wacholder, Sholom AU - Sherman, Mark AU - Solomon, Diane AU - Safaeian, Mahboobeh AU - Rodriguez, Ana AU - Bougelet, Catherine AU - van Doorn, Leen-Jan Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Costa Rica KW - Human papillomavirus 16 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866052656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Seroprevalence+and+Determinants+of+Human+Papillomavirus+16%2F18+Seropositivity+among+Young+Women+in+Costa+Rica&rft.au=Coseo%2C+Sarah%3BPorras%2C+Carolina%3BSchiffman%2C+Mark%3BWacholder%2C+Sholom%3BSherman%2C+Mark%3BSolomon%2C+Diane%3BSafaeian%2C+Mahboobeh%3BRodriguez%2C+Ana%3BBougelet%2C+Catherine%3Bvan+Doorn%2C+Leen-Jan&rft.aulast=Coseo&rft.aufirst=Sarah&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Longitudinal analysis of type-specific HPV infection, viral load, and cytologic abnormality in the Guanacaste Cohort T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866052375; 5968342 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Coseo, Sarah AU - Hildesheim, Allan AU - Schiffman, Mark AU - Rodriguez, Ana AU - Herrero, Rolando AU - Burk, Robert Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Costa Rica, Guanacaste KW - infection KW - Infection KW - Viral diseases KW - Abnormalities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866052375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Longitudinal+analysis+of+type-specific+HPV+infection%2C+viral+load%2C+and+cytologic+abnormality+in+the+Guanacaste+Cohort&rft.au=Coseo%2C+Sarah%3BHildesheim%2C+Allan%3BSchiffman%2C+Mark%3BRodriguez%2C+Ana%3BHerrero%2C+Rolando%3BBurk%2C+Robert&rft.aulast=Coseo&rft.aufirst=Sarah&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Pten, Hdlg and p53 Abnormal Expression in Cervical Carcinogenesis T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866051749; 5968028 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Vazquez Ulloa, Elenae AU - Contreras Paredes, Adriana AU - Aviles Salas, Alejandro AU - Lizano Soberon, Marcela Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Carcinogenesis KW - Cervix KW - p53 protein KW - PTEN protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866051749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Pten%2C+Hdlg+and+p53+Abnormal+Expression+in+Cervical+Carcinogenesis&rft.au=Vazquez+Ulloa%2C+Elenae%3BContreras+Paredes%2C+Adriana%3BAviles+Salas%2C+Alejandro%3BLizano+Soberon%2C+Marcela&rft.aulast=Vazquez+Ulloa&rft.aufirst=Elenae&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Development of a GuHCl-modified ELISA for measuring the avidity of anti-HPV VLP antibodies T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866051569; 5967946 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Dauner, Joseph AU - Pan, Yuanji AU - Kemp, Troy AU - Pinto, Ligia AU - Hildesheim, Allan AU - Porras, Carolina Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Avidity KW - Antibodies KW - ELISA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866051569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Development+of+a+GuHCl-modified+ELISA+for+measuring+the+avidity+of+anti-HPV+VLP+antibodies&rft.au=Dauner%2C+Joseph%3BPan%2C+Yuanji%3BKemp%2C+Troy%3BPinto%2C+Ligia%3BHildesheim%2C+Allan%3BPorras%2C+Carolina&rft.aulast=Dauner&rft.aufirst=Joseph&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Additional data needed for a systematic review on efficacy of prophylactic HPV vaccination T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866051276; 5967788 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Hildesheim, Allan Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Reviews KW - Vaccination KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866051276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Additional+data+needed+for+a+systematic+review+on+efficacy+of+prophylactic+HPV+vaccination&rft.au=Hildesheim%2C+Allan&rft.aulast=Hildesheim&rft.aufirst=Allan&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Biological Efect of HPV18 E6*I T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866051214; 5968079 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Manzo, Joaquin AU - Fuentes, Alma AU - Lizano, Marcela AU - Hernandez, Jose AU - Contreras, Adriana Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - {Q2} KW - Human papillomavirus 18 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866051214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Biological+Efect+of+HPV18+E6*I&rft.au=Manzo%2C+Joaquin%3BFuentes%2C+Alma%3BLizano%2C+Marcela%3BHernandez%2C+Jose%3BContreras%2C+Adriana&rft.aulast=Manzo&rft.aufirst=Joaquin&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2011-05-12 ER - TY - CPAPER T1 - New Molecular Markers for Cervical Cancer Screening: Distinguishing Hype from Hope T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866051114; 5967742 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Castle, Phillip Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Cervical cancer KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866051114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=New+Molecular+Markers+for+Cervical+Cancer+Screening%3A+Distinguishing+Hype+from+Hope&rft.au=Castle%2C+Phillip&rft.aulast=Castle&rft.aufirst=Phillip&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - The relationship between memory B cells and systemic antibodies after HPV VLP vaccination T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866050999; 5967945 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Dauner, Joseph AU - Pan, Yuanji AU - Pinto, Ligia AU - Hildesheim, Allan AU - Harro, Clayton Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Vaccination KW - Lymphocytes B KW - Memory cells KW - Antibodies KW - Immunological memory UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866050999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=The+relationship+between+memory+B+cells+and+systemic+antibodies+after+HPV+VLP+vaccination&rft.au=Dauner%2C+Joseph%3BPan%2C+Yuanji%3BPinto%2C+Ligia%3BHildesheim%2C+Allan%3BHarro%2C+Clayton&rft.aulast=Dauner&rft.aufirst=Joseph&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - A competitive serology assay shows protection against HPV infection by natural titers in the Guanacaste Natural History Study T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866050925; 5967941 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Wentzensen, Nicolas AU - Hildesheim, Allan AU - Wacholder, Sholom AU - Safaeian, Mahboobeh AU - Schiffman, Mark AU - Rodriguez, Ana AU - Herrero, Rolando AU - Morales, Jorge AU - Viscidi, Raphael AU - Burk, Robert Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Costa Rica, Guanacaste KW - infection KW - Historical account KW - Infection KW - Serology KW - Serological studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866050925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=A+competitive+serology+assay+shows+protection+against+HPV+infection+by+natural+titers+in+the+Guanacaste+Natural+History+Study&rft.au=Wentzensen%2C+Nicolas%3BHildesheim%2C+Allan%3BWacholder%2C+Sholom%3BSafaeian%2C+Mahboobeh%3BSchiffman%2C+Mark%3BRodriguez%2C+Ana%3BHerrero%2C+Rolando%3BMorales%2C+Jorge%3BViscidi%2C+Raphael%3BBurk%2C+Robert&rft.aulast=Wentzensen&rft.aufirst=Nicolas&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Risk of cervical precancer or cancer in 330,790 women undergoing co-testing with HPV testing and Pap smears T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866050882; 5967902 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Katki, Hormuzd AU - Castle, Philip AU - Kinney, Walter AU - Fetterman, Barbara AU - Lorey, Thomas AU - Poitras, Nancy Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Cancer KW - Cervix KW - Human papillomavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866050882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Risk+of+cervical+precancer+or+cancer+in+330%2C790+women+undergoing+co-testing+with+HPV+testing+and+Pap+smears&rft.au=Katki%2C+Hormuzd%3BCastle%2C+Philip%3BKinney%2C+Walter%3BFetterman%2C+Barbara%3BLorey%2C+Thomas%3BPoitras%2C+Nancy&rft.aulast=Katki&rft.aufirst=Hormuzd&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Epidemiologic Study of anti HPV16/18 seropositivity and subsequent risk of HPV16 and 18 infections T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866050517; 5967811 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Safaeian, Mahboobeh AU - Schiffman, Mark AU - Wacholder, Sholom AU - Hildesheim, Allan AU - Porras, Carolina AU - Rodriguez, Ana AU - Gonzalez, Paula AU - Herrero, Rolando AU - Quint, Wim AU - Xhenseval, Valerie Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - infection KW - Infection KW - Human papillomavirus 16 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866050517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Epidemiologic+Study+of+anti+HPV16%2F18+seropositivity+and+subsequent+risk+of+HPV16+and+18+infections&rft.au=Safaeian%2C+Mahboobeh%3BSchiffman%2C+Mark%3BWacholder%2C+Sholom%3BHildesheim%2C+Allan%3BPorras%2C+Carolina%3BRodriguez%2C+Ana%3BGonzalez%2C+Paula%3BHerrero%2C+Rolando%3BQuint%2C+Wim%3BXhenseval%2C+Valerie&rft.aulast=Safaeian&rft.aufirst=Mahboobeh&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Oral HPV persistence at 6- and 12- months among healthy men: The HIM Study T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866050278; 5967727 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Kreimer, Aimee AU - Hildesheim, Allan AU - Abrahamsen, Martha AU - Smith, Danelle AU - Papenfuss, Mary AU - Giuliano, Anna AU - Villa, Luisa AU - Lazcano, Eduardo Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866050278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Oral+HPV+persistence+at+6-+and+12-+months+among+healthy+men%3A+The+HIM+Study&rft.au=Kreimer%2C+Aimee%3BHildesheim%2C+Allan%3BAbrahamsen%2C+Martha%3BSmith%2C+Danelle%3BPapenfuss%2C+Mary%3BGiuliano%2C+Anna%3BVilla%2C+Luisa%3BLazcano%2C+Eduardo&rft.aulast=Kreimer&rft.aufirst=Aimee&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2011-05-12 ER - TY - CPAPER T1 - Analysis of HPV genotype patterns in ALTS using unsupervised hierarchical clustering T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866050246; 5968352 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Wilson, Lauren AU - Wentzensen, Nicolas AU - Carreon, J AU - Schiffman, Mark AU - Castle, Philip AU - Gravitt, Patti AU - Wheeler, Cosette Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Genotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866050246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Analysis+of+HPV+genotype+patterns+in+ALTS+using+unsupervised+hierarchical+clustering&rft.au=Wilson%2C+Lauren%3BWentzensen%2C+Nicolas%3BCarreon%2C+J%3BSchiffman%2C+Mark%3BCastle%2C+Philip%3BGravitt%2C+Patti%3BWheeler%2C+Cosette&rft.aulast=Wilson&rft.aufirst=Lauren&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Switch from Cytology-based to HPV-based Cervical Screening: Implications for Colposcopy T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866049801; 5967862 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Porras, Carolina AU - Wentzensen, Nicolas AU - Wacholder, Sholom AU - Hildesheim, Allan AU - Schiffman, Mark AU - Rodriguez, Ana AU - Morales, Jorge AU - Herrero, Rolando AU - Burk, Robert Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Colposcopy KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866049801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Switch+from+Cytology-based+to+HPV-based+Cervical+Screening%3A+Implications+for+Colposcopy&rft.au=Porras%2C+Carolina%3BWentzensen%2C+Nicolas%3BWacholder%2C+Sholom%3BHildesheim%2C+Allan%3BSchiffman%2C+Mark%3BRodriguez%2C+Ana%3BMorales%2C+Jorge%3BHerrero%2C+Rolando%3BBurk%2C+Robert&rft.aulast=Porras&rft.aufirst=Carolina&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Proof-of-Principle: Efficacy of fewer than 3-doses of a bivalent HPV 16/18 vaccine against incident persistent HPV infection in Guanacaste, Costa Rica T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866048983; 5967905 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Kreimer, Aimee AU - Hildesheim, Allan AU - Schiffman, Mark AU - Solomon, Diane AU - Schiller, John AU - Rodriguez, Ana AU - Herrero, Rolando AU - Porras, Carolina AU - Gonzalez, Paula AU - Jimenez, Silvia Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Costa Rica, Guanacaste KW - infection KW - vaccines KW - Infection KW - Vaccines KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866048983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Proof-of-Principle%3A+Efficacy+of+fewer+than+3-doses+of+a+bivalent+HPV+16%2F18+vaccine+against+incident+persistent+HPV+infection+in+Guanacaste%2C+Costa+Rica&rft.au=Kreimer%2C+Aimee%3BHildesheim%2C+Allan%3BSchiffman%2C+Mark%3BSolomon%2C+Diane%3BSchiller%2C+John%3BRodriguez%2C+Ana%3BHerrero%2C+Rolando%3BPorras%2C+Carolina%3BGonzalez%2C+Paula%3BJimenez%2C+Silvia&rft.aulast=Kreimer&rft.aufirst=Aimee&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Endpoint maturation of the HPV16 capsid T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866048920; 5967879 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Buck, Chris AU - Moyer, Adam AU - Dvoretzky, Israel AU - Cheng, Naiqian AU - Steven, Alasdair AU - Trus, Benes Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Capsids KW - Sexual maturity KW - Human papillomavirus 16 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866048920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Endpoint+maturation+of+the+HPV16+capsid&rft.au=Buck%2C+Chris%3BMoyer%2C+Adam%3BDvoretzky%2C+Israel%3BCheng%2C+Naiqian%3BSteven%2C+Alasdair%3BTrus%2C+Benes&rft.aulast=Buck&rft.aufirst=Chris&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Genital Immunization with HPV Pseudovirions Induces Persistent Effector Memory CD8+ T-Cell Responses in the Mouse Genital Tract T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866048833; 5968006 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Cuburu, Nicolas AU - Kines, Rhonda AU - Roberts, Jeffrey AU - Buck, Christopher AU - Lowy, Douglas AU - Schiller, John AU - Nicewonger, John AU - Graham, Barney Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - immunization KW - CD8 antigen KW - Lymphocytes T KW - Immunological memory KW - Immunization KW - Genital tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866048833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Genital+Immunization+with+HPV+Pseudovirions+Induces+Persistent+Effector+Memory+CD8%2B+T-Cell+Responses+in+the+Mouse+Genital+Tract&rft.au=Cuburu%2C+Nicolas%3BKines%2C+Rhonda%3BRoberts%2C+Jeffrey%3BBuck%2C+Christopher%3BLowy%2C+Douglas%3BSchiller%2C+John%3BNicewonger%2C+John%3BGraham%2C+Barney&rft.aulast=Cuburu&rft.aufirst=Nicolas&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Secular trends of HPVdistribution in invasive cervical cancer, Colombia 1950-2000 T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866048716; 5967816 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Hernandez-Suarez, Gustavo AU - Bravo, Luis AU - Munoz, Nubia Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Colombia KW - Cervical cancer KW - Invasiveness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866048716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Secular+trends+of+HPVdistribution+in+invasive+cervical+cancer%2C+Colombia+1950-2000&rft.au=Hernandez-Suarez%2C+Gustavo%3BBravo%2C+Luis%3BMunoz%2C+Nubia&rft.aulast=Hernandez-Suarez&rft.aufirst=Gustavo&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Human Keratinocytes are Immortalized by a Rho Kinase Inhibitor T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866048557; 5967756 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Chapman, Sandra AU - McBride, Alison AU - Liu, Xuefeng AU - Schlegel, Richard AU - Meyers, Craig Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Rho-associated kinase KW - Keratinocytes KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866048557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Human+Keratinocytes+are+Immortalized+by+a+Rho+Kinase+Inhibitor&rft.au=Chapman%2C+Sandra%3BMcBride%2C+Alison%3BLiu%2C+Xuefeng%3BSchlegel%2C+Richard%3BMeyers%2C+Craig&rft.aulast=Chapman&rft.aufirst=Sandra&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Oral and anal HPV infection among HIV-infected men and women T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866048514; 5968264 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Chaturvedi, Anil AU - Xiao, Weihong AU - Gillison, Maura Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - infection KW - Infection KW - Human immunodeficiency virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866048514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Oral+and+anal+HPV+infection+among+HIV-infected+men+and+women&rft.au=Chaturvedi%2C+Anil%3BXiao%2C+Weihong%3BGillison%2C+Maura&rft.aulast=Chaturvedi&rft.aufirst=Anil&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Absolute risks of CIN and cancer in a 16-year prospective study of type-specific HPV infection T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866048159; 5967807 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Schiffman, Mark AU - Wacholder, Sholom AU - Wentzensen, Nicolas AU - Castle, Philip AU - Sherman, Mark AU - Glass, Andrew AU - Rush, Brenda AU - Scott, David AU - Burk, Robert Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Cancer KW - infection KW - Infection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866048159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Absolute+risks+of+CIN+and+cancer+in+a+16-year+prospective+study+of+type-specific+HPV+infection&rft.au=Schiffman%2C+Mark%3BWacholder%2C+Sholom%3BWentzensen%2C+Nicolas%3BCastle%2C+Philip%3BSherman%2C+Mark%3BGlass%2C+Andrew%3BRush%2C+Brenda%3BScott%2C+David%3BBurk%2C+Robert&rft.aulast=Schiffman&rft.aufirst=Mark&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Impact of Performing Multiple Biopsies on the Detection of Precancer in the Nci-Ouhsc Biopsy Study T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866047868; 5967714 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Wentzensen, Nicolas AU - Schiffman, Mark AU - Walker, Joan AU - Zuna, Rosemary AU - Smith, Katie AU - Mathews, Cara AU - Moxley, Katherine AU - Zhang, Roy AU - Gold, Michael Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Biopsy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866047868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Impact+of+Performing+Multiple+Biopsies+on+the+Detection+of+Precancer+in+the+Nci-Ouhsc+Biopsy+Study&rft.au=Wentzensen%2C+Nicolas%3BSchiffman%2C+Mark%3BWalker%2C+Joan%3BZuna%2C+Rosemary%3BSmith%2C+Katie%3BMathews%2C+Cara%3BMoxley%2C+Katherine%3BZhang%2C+Roy%3BGold%2C+Michael&rft.aulast=Wentzensen&rft.aufirst=Nicolas&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - HPV testing for the triage of ASCUS and LSIL: Principles and results T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866047352; 5967645 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Castle, Philip Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866047352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=HPV+testing+for+the+triage+of+ASCUS+and+LSIL%3A+Principles+and+results&rft.au=Castle%2C+Philip&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/images/stories/downloads/HPV2010_FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2011-05-12 ER - TY - CPAPER T1 - Construction of a complete transcription map of HPV18 in productive viral infection T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866046888; 5967804 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Wang, Xiaohong AU - Zheng, Zhi-Ming AU - Meyers, Craig Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - infection KW - Infection KW - Transcription KW - Viral diseases KW - Human papillomavirus 18 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866046888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Construction+of+a+complete+transcription+map+of+HPV18+in+productive+viral+infection&rft.au=Wang%2C+Xiaohong%3BZheng%2C+Zhi-Ming%3BMeyers%2C+Craig&rft.aulast=Wang&rft.aufirst=Xiaohong&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - International trends in incidence for HPV-related head and neck cancer sites T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866046671; 5968265 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Chaturvedi, Anil AU - Anderson, William AU - Curado, Maria AU - Franceschi, Silvia AU - Gillison, Maura Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Head and neck cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866046671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=International+trends+in+incidence+for+HPV-related+head+and+neck+cancer+sites&rft.au=Chaturvedi%2C+Anil%3BAnderson%2C+William%3BCurado%2C+Maria%3BFranceschi%2C+Silvia%3BGillison%2C+Maura&rft.aulast=Chaturvedi&rft.aufirst=Anil&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - l2 Vaccine-Induced Antibodies Have Greater Potency in Vivo than Predicted from in Vitro Assays T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866046594; 5967709 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Kines, Rhonda AU - Day, Patricia AU - Thompson, Cynthia AU - Pang, Yuk-Ying AU - Lowy, Douglas AU - Schiller, John AU - Jagu, Subhashini AU - Roden, Richard Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - vaccines KW - Antibodies KW - Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866046594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=l2+Vaccine-Induced+Antibodies+Have+Greater+Potency+in+Vivo+than+Predicted+from+in+Vitro+Assays&rft.au=Kines%2C+Rhonda%3BDay%2C+Patricia%3BThompson%2C+Cynthia%3BPang%2C+Yuk-Ying%3BLowy%2C+Douglas%3BSchiller%2C+John%3BJagu%2C+Subhashini%3BRoden%2C+Richard&rft.aulast=Kines&rft.aufirst=Rhonda&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/images/stories/downloads/HPV2010_FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - HPV pseudoviruses as gene delivery vectors for murine tumors and human ovarian tumor xenografts T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866046562; 5968018 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Cerio, Rebecca AU - Roberts, Jeffrey AU - Lowy, Douglas AU - Schiller, John Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - tumors KW - Tumors KW - Xenografts KW - Gene transfer KW - Ovaries KW - Human papillomavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866046562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=HPV+pseudoviruses+as+gene+delivery+vectors+for+murine+tumors+and+human+ovarian+tumor+xenografts&rft.au=Cerio%2C+Rebecca%3BRoberts%2C+Jeffrey%3BLowy%2C+Douglas%3BSchiller%2C+John&rft.aulast=Cerio&rft.aufirst=Rebecca&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Efficacy of a bivalent HPV 16/18 vaccine for prevention of 1-year HPV persistence by age group and sexual history: randomized trial in Guanacaste, Costa Rica T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866046266; 5967887 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Herrero, Rolando AU - Porras, Carolina AU - Rodriguez, Ana AU - Gonzalez, Paula AU - Jimenez, Silvia AU - Wacholder, Sholom AU - Schiffman, Mark AU - Solomon, Diane AU - Kreimer, Aimee AU - Hildesheim, Allan Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Costa Rica, Guanacaste KW - prevention KW - vaccines KW - Historical account KW - Age KW - Vaccines KW - Age groups KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866046266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Efficacy+of+a+bivalent+HPV+16%2F18+vaccine+for+prevention+of+1-year+HPV+persistence+by+age+group+and+sexual+history%3A+randomized+trial+in+Guanacaste%2C+Costa+Rica&rft.au=Herrero%2C+Rolando%3BPorras%2C+Carolina%3BRodriguez%2C+Ana%3BGonzalez%2C+Paula%3BJimenez%2C+Silvia%3BWacholder%2C+Sholom%3BSchiffman%2C+Mark%3BSolomon%2C+Diane%3BKreimer%2C+Aimee%3BHildesheim%2C+Allan&rft.aulast=Herrero&rft.aufirst=Rolando&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Activation of two novel 5' splice site usage in RNA splicing of HPV16 E6E7 intron 1 T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866046070; 5968052 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Jia, Rong AU - Zhang, Lifang AU - Tao, Mingfang AU - Wang, Xiaohong AU - Zheng, Zhi-Ming Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - introns KW - Splicing KW - Introns KW - RNA KW - Human papillomavirus 16 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866046070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Activation+of+two+novel+5%27+splice+site+usage+in+RNA+splicing+of+HPV16+E6E7+intron+1&rft.au=Jia%2C+Rong%3BZhang%2C+Lifang%3BTao%2C+Mingfang%3BWang%2C+Xiaohong%3BZheng%2C+Zhi-Ming&rft.aulast=Jia&rft.aufirst=Rong&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/index.php?option=com_conference&view=day&conference=1&day=3&Itemid=100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - Critical issues: Safety, duration of protection, cross-protection T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866045833; 5967655 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Lowy, Douglas Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - Cross-protection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866045833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=Critical+issues%3A+Safety%2C+duration+of+protection%2C+cross-protection&rft.au=Lowy%2C+Douglas&rft.aulast=Lowy&rft.aufirst=Douglas&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/images/stories/downloads/HPV2010_FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - CPAPER T1 - HPV: Natural history of the infection from the epidemiological and clinical perspective T2 - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AN - 866045749; 5967638 JF - 26th International Papillomavirus Conference and Clinical Workshop (HPV 2010) AU - Schiffman, Mark Y1 - 2010/07/03/ PY - 2010 DA - 2010 Jul 03 KW - infection KW - Historical account KW - Infection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866045749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.atitle=HPV%3A+Natural+history+of+the+infection+from+the+epidemiological+and+clinical+perspective&rft.au=Schiffman%2C+Mark&rft.aulast=Schiffman&rft.aufirst=Mark&rft.date=2010-07-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Papillomavirus+Conference+and+Clinical+Workshop+%28HPV+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://hpv2010.org/main/images/stories/downloads/HPV2010_FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - JOUR T1 - Pathologic role of stressed-induced glucocorticoids in drug-induced liver injury in mice AN - 759309318; 13217678 AB - We previously reported that acetaminophen (APAP)-induced liver injury (AILI) in mice is associated with a rise in serum levels of the glucocorticoid (GC), corticosterone. In the current study, we provide evidence that endogenous GC play a pathologic role in AILI. Specifically, pretreatment of mice with the GC receptor (GCR) inhibitor, RU486 (mifepristrone), protected normal but not adrenalectomized mice from AILI, while pretreatment with dexamethasone, a synthetic GC, exacerbated AILI. RU486 did not affect the depletion of whole liver reduced GSH or the formation of APAP-protein adducts. It also had no effects on the formation of reactive oxygen species or the depletion of mitochondrial GSH or ATP. While RU486 pretreatment also protected against halothane-induced liver injury, it exacerbated concanavalin A (ConA)- and carbon tetrachloride (CCl4)-induced liver injury, demonstrating the complexity of GC effects in different types of liver injury. Conclusion: These results suggest that under certain conditions, elevated levels of GC might represent a previously unappreciated risk factor for liver injury caused by APAP and other drugs through the diverse biological processes regulated by GCR. JF - Biochemical and Biophysical Research Communications AU - Masson, Mary Jane AU - Collins, Lindsay A AU - Carpenter, Leah D AU - Graf, Mary L AU - Ryan, Pauline M AU - Bourdi, Mohammed AU - Pohl, Lance R AD - Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA Y1 - 2010/07/02/ PY - 2010 DA - 2010 Jul 02 SP - 453 EP - 458 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 397 IS - 3 SN - 0006-291X, 0006-291X KW - Toxicology Abstracts KW - APAP KW - AILI KW - GC KW - GCR KW - ConA KW - CCl4 KW - DILI KW - NAPQI KW - H� ALT KW - MPT KW - ROS KW - Drug-induced liver injury KW - Stress KW - RU486 KW - Acetaminophen KW - Halothane KW - Dexamethasone KW - Injuries KW - Adducts KW - Mitochondria KW - ATP KW - Glucocorticoids KW - Serum levels KW - Corticosterone KW - Carbon tetrachloride KW - Concanavalin A KW - Reactive oxygen species KW - Risk factors KW - Liver KW - Drugs KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759309318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Pathologic+role+of+stressed-induced+glucocorticoids+in+drug-induced+liver+injury+in+mice&rft.au=Masson%2C+Mary+Jane%3BCollins%2C+Lindsay+A%3BCarpenter%2C+Leah+D%3BGraf%2C+Mary+L%3BRyan%2C+Pauline+M%3BBourdi%2C+Mohammed%3BPohl%2C+Lance+R&rft.aulast=Masson&rft.aufirst=Mary&rft.date=2010-07-02&rft.volume=397&rft.issue=3&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2010.05.126 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Dexamethasone; Injuries; Adducts; ATP; Mitochondria; Glucocorticoids; Serum levels; Corticosterone; Carbon tetrachloride; Concanavalin A; Reactive oxygen species; Risk factors; Liver; Drugs; Acetaminophen DO - http://dx.doi.org/10.1016/j.bbrc.2010.05.126 ER - TY - JOUR T1 - A Repeat Call for the Banning of Asbestos AN - 918039039; 13640160 JF - Environmental Health Perspectives AU - Birnbaum, Linda S AU - Schroeder, Jane C AU - Tilson, Hugh A AD - NIEHS and NTP, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - A280 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 118 IS - 7 SN - 0091-6765, 0091-6765 KW - Environment Abstracts KW - Asbestos KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918039039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Repeat+Call+for+the+Banning+of+Asbestos&rft.au=Birnbaum%2C+Linda+S%3BSchroeder%2C+Jane+C%3BTilson%2C+Hugh+A&rft.aulast=Birnbaum&rft.aufirst=Linda&rft.date=2010-07-01&rft.volume=118&rft.issue=7&rft.spage=A280&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002419 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Asbestos DO - http://dx.doi.org/10.1289/ehp.1002419 ER - TY - JOUR T1 - RT-GROG: parallelized self-calibrating GROG for real-time MRI AN - 883036347; 15255632 AB - A real-time implementation of self-calibrating Generalized Autocalibrating Partially Parallel Acquisitions (GRAPPA) operator gridding for radial acquisitions is presented. Self-calibrating GRAPPA operator gridding is a parallel-imaging-based, parameter-free gridding algorithm, where coil sensitivity profiles are used to calculate gridding weights. Self-calibrating GRAPPA operator gridding's weight-set calculation and image reconstruction steps are decoupled into two distinct processes, implemented in C++ and parallelized. This decoupling allows the weights to be updated adaptively in the background while image reconstruction threads use the most recent gridding weights to grid and reconstruct images. All possible combinations of two-dimensional gridding weights GG are evaluated for m,n = {-0.5, -0.4, ..., ,0.1, ..., 0.5} and stored in a look-up table. Consequently, the per-sample two-dimensional weights calculation during gridding is eliminated from the reconstruction process and replaced by a simple look-up table access. In practice, up to 34X faster reconstruction than conventional (parallelized) self-calibrating GRAPPA operator gridding is achieved. On a 32-coil dataset of size 128 X 64, reconstruction performance is 14.5 frames per second (fps), while the data acquisition is 6.6 fps. Magn Reson Med 64:306-312, 2010. [copy 2010 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Saybasili, Haris AU - Derbyshire, J Andrew AU - Kellman, Peter AU - Griswold, Mark A AU - Ozturk, Cengizhan AU - Lederman, Robert J AU - Seiberlich, Nicole AD - Translational Medicine Branch, National Institutes of Health/National Heart, Lung and Blood Institute (NHLBI), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA, saybasilih@nhlbi.nih.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 306 EP - 312 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 64 IS - 1 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Magnetic resonance imaging KW - Algorithms KW - Image processing KW - N.M.R. KW - Data acquisition KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883036347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=RT-GROG%3A+parallelized+self-calibrating+GROG+for+real-time+MRI&rft.au=Saybasili%2C+Haris%3BDerbyshire%2C+J+Andrew%3BKellman%2C+Peter%3BGriswold%2C+Mark+A%3BOzturk%2C+Cengizhan%3BLederman%2C+Robert+J%3BSeiberlich%2C+Nicole&rft.aulast=Saybasili&rft.aufirst=Haris&rft.date=2010-07-01&rft.volume=64&rft.issue=1&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22351 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22351/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Algorithms; Image processing; N.M.R.; Data acquisition DO - http://dx.doi.org/10.1002/mrm.22351 ER - TY - JOUR T1 - The use of quantum dot nanocrystals in multicolor flow cytometry AN - 869574961; 14821155 AB - Because of their unique fluorescence properties, quantum dots (QDs) represent a promising new technology in the realm of multicolor flow cytometry. Although commercial reagents and applications for the technology are still in the early phases of their development, the strategies and considerations necessary for successful use are becoming known. This article discusses the value of QDs in multicolor flow cytometry, introduces strategies to successfully incorporate QDs into routine use, and highlights emerging applications of the technology. WIREs Nanomed Nanobiotechnol 2010 2 334-348 JF - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology AU - Chattopadhyay, Pratip K AU - Perfetto, Stephen P AU - Yu, Joanne AU - Roederer, Mario AD - ImmunoTechnology Section, Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA, pchattop@mail.nih.gov Y1 - 2010/07/01/ PY - 2010 DA - 2010 Jul 01 SP - 334 EP - 348 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK VL - 2 IS - 4 SN - 1939-0041, 1939-0041 KW - Biotechnology and Bioengineering Abstracts KW - Flow cytometry KW - Fluorescence KW - Quantum dots KW - Crystals KW - nanotechnology KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869574961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.atitle=The+use+of+quantum+dot+nanocrystals+in+multicolor+flow+cytometry&rft.au=Chattopadhyay%2C+Pratip+K%3BPerfetto%2C+Stephen+P%3BYu%2C+Joanne%3BRoederer%2C+Mario&rft.aulast=Chattopadhyay&rft.aufirst=Pratip&rft.date=2010-07-01&rft.volume=2&rft.issue=4&rft.spage=334&rft.isbn=&rft.btitle=&rft.title=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.issn=19390041&rft_id=info:doi/10.1002%2Fwnan.75 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Fluorescence; Quantum dots; Crystals; nanotechnology DO - http://dx.doi.org/10.1002/wnan.75 ER - TY - JOUR T1 - Pesticide Use and Myocardial Infarction Incidence Among Farm Women in the Agricultural Health Study AN - 867737104; 14690980 AB - Objective: To evaluate the relationship between pesticide use and myocardial infarction (MI) among farm women. Background: Little is known about the potential association between pesticide use and cardiovascular outcomes. Methods: We used logistic regression to evaluate pesticide use and self-reported incident nonfatal MI among women in the Agricultural Health Study. Results: Of those Mi-free at enrollment (n = 22,425), 168 reported an MI after enrollment. We saw no association with pesticide use overall. Six of 27 individual pesticides evaluated were significantly associated with nonfatal MI, including chlorpyrifos, coumaphos, carbofuran, metalaxyl, pendimethalin, and trifluralin, which all had odds ratios >1.7. These chemicals were used by <10% of the cases, and their use was correlated, making it difficult to attribute the risk elevation to a specific pesticide. Conclusion: Pesticides may contribute to MI risk among farm women. JF - Journal of Occupational and Environmental Medicine AU - Dayton, S B AU - Sandler, D P AU - Blair, A AU - Alavanja, M AU - Freeman, LEB AU - Hoppin, JA AD - NIEHS, Epidemiology Branch, MD A3-05, PO Box 12233, Research Triangle Park, NC 27709-2233, USA, hoppin1@niehs.nih.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 693 EP - 697 VL - 52 IS - 7 SN - 1076-2752, 1076-2752 KW - Risk Abstracts KW - Chemicals KW - myocardial infarction KW - carbofuran KW - Chlorpyrifos KW - farms KW - Pesticides KW - Trifluralin KW - Females KW - pendimethalin KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867737104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Pesticide+Use+and+Myocardial+Infarction+Incidence+Among+Farm+Women+in+the+Agricultural+Health+Study&rft.au=Dayton%2C+S+B%3BSandler%2C+D+P%3BBlair%2C+A%3BAlavanja%2C+M%3BFreeman%2C+LEB%3BHoppin%2C+JA&rft.aulast=Dayton&rft.aufirst=S&rft.date=2010-07-01&rft.volume=52&rft.issue=7&rft.spage=693&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181e66d25 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Chlorpyrifos; Chemicals; myocardial infarction; farms; Pesticides; Trifluralin; carbofuran; Females; pendimethalin DO - http://dx.doi.org/10.1097/JOM.0b013e3181e66d25 ER - TY - JOUR T1 - Trunk and Hip Muscle Activation Patterns Are Different During Walking in Young Children With and Without Cerebral Palsy AN - 860386440; 14539809 AB - Background Poor control of postural muscles is a primary impairment in people with cerebral palsy (CP). Objective The purpose of this study was to investigate differences in the timing characteristics of trunk and hip muscle activity during walking in young children with CP compared with children with typical development (TD). Methods Thirty-one children (16 with TD, 15 with CP) with an average of 28.5 months of walking experience participated in this observational study. Electromyographic data were collected from 16 trunk and hip muscles as participants walked at a self-selected pace. A custom-written computer program determined onset and offset of activity. Activation and coactivation data were analyzed for group differences. Results The children with CP had greater total activation and coactivation for all muscles except the external oblique muscle and differences in the timing of activation for all muscles compared with the TD group. The implications of the observed muscle activation patterns are discussed in reference to existing postural control literature. Limitations The potential influence of recording activity from adjacent deep trunk muscles is discussed, as well as the influence of the use of an assistive device by some children with CP. Conclusions Young children with CP demonstrate excessive, nonreciprocal trunk and hip muscle activation during walking compared with children with TD. Future studies should investigate the efficacy of treatments to reduce excessive muscle activity and improve coordination of postural muscles in CP. JF - Physical Therapy AU - Prosser, LA AU - Lee, SCK AU - VanSant, A F AU - Barbe, M F AU - Lauer, R T AD - Rehabilitation Medicine Department, National Institutes of Health Clinical Center, Bldg 10-CRC, 1-1469, 10 Center Dr, Bethesda MD 20892 (USA), laura.prosser@nih.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 986 EP - 997 VL - 90 IS - 7 SN - 0031-9023, 0031-9023 KW - Physical Education Index KW - Coordination KW - Trunk KW - Cerebral palsy KW - Walking KW - Muscles (activity) KW - Children KW - Posture KW - Hips KW - Youth KW - PE 110:Physical Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860386440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physical+Therapy&rft.atitle=Trunk+and+Hip+Muscle+Activation+Patterns+Are+Different+During+Walking+in+Young+Children+With+and+Without+Cerebral+Palsy&rft.au=Prosser%2C+LA%3BLee%2C+SCK%3BVanSant%2C+A+F%3BBarbe%2C+M+F%3BLauer%2C+R+T&rft.aulast=Prosser&rft.aufirst=LA&rft.date=2010-07-01&rft.volume=90&rft.issue=7&rft.spage=986&rft.isbn=&rft.btitle=&rft.title=Physical+Therapy&rft.issn=00319023&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2011-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Coordination; Trunk; Cerebral palsy; Walking; Muscles (activity); Posture; Children; Youth; Hips ER - TY - JOUR T1 - The relationship context of nonmarital childbearing in the U.S. AN - 853213287; 4167267 AB - Using Early Childhood Longitudinal Study-Birth Cohort data, we update estimates of cohabiting nonmarital births, examine factors associated with relationship context at birth, and assess racial/ethnic differences. We find that 52% of nonmarital births occur within cohabitations an increase of 33% since the early 1990s. Blacks have shown the greatest increase in cohabiting births over time. We also find that the fertility histories of men and women have opposite influences on nonmarital childbearing. Furthermore, for Whites, a partner of a different race/ethnicity is associated with a higher risk of a nonmarital birth; for Blacks and Hispanics, the opposite is true. JF - Demographic research AU - Manlove, Jennifer AU - Ryan, Suzanne AU - Wildsmith, Elizabeth AU - Franzetta, Kerry AD - Child Trends, Washington DC ; National Institutes of Health, Bethesda ; University of Pennsylvania Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 615 EP - 654 VL - 23 SN - 1435-9871, 1435-9871 KW - Sociology KW - Whites KW - Birth KW - Longitudinal studies KW - Fertility KW - Cohabitation KW - Blacks KW - Marital status KW - Surveys KW - Sexual reproduction KW - Estimation KW - U.S.A. UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853213287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Demographic+research&rft.atitle=The+relationship+context+of+nonmarital+childbearing+in+the+U.S.&rft.au=Manlove%2C+Jennifer%3BRyan%2C+Suzanne%3BWildsmith%2C+Elizabeth%3BFranzetta%2C+Kerry&rft.aulast=Manlove&rft.aufirst=Jennifer&rft.date=2010-07-01&rft.volume=23&rft.issue=&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=Demographic+research&rft.issn=14359871&rft_id=info:doi/10.4054%2FDemRes.2010.23.22 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - SuppNotes - Open access N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11574; 7699 7748 6823; 12429; 7541 7537 971; 4403 7854; 1635 11574; 1656 10555 6091; 2454 6823 6040 5676; 4869 3409 6306; 13552 10555 6091; 433 293 14 DO - http://dx.doi.org/10.4054/DemRes.2010.23.22 ER - TY - JOUR T1 - Incentive-elicited mesolimbic activation and externalizing symptomatology in adolescents AN - 839571410; 201100358 AB - Background: Opponent-process theories of externalizing disorders (ExD) attribute them to some combination of overactive reward processing systems and-or underactive behavior inhibition systems. Reward processing has been indexed by recruitment of incentive-motivational neurocircuitry of the ventral striatum (VS), including nucleus accumbens (NAcc). Methods: We used functional magnetic resonance imaging (fMRI) with an incentive task to determine whether externalizing symptomatology in adolescence is correlated with an enhanced VS recruitment by cues for rewards, or by deliveries of rewards. Twelve community-recruited adolescents with externalizing disorders (AED) and 12 age-gender-matched controls responded to targets to win or avoid losing $0, $0.20, $1, $5, or an unknown amount (ranging from $0.20 to $5). Results: Cues to respond for rewards activated the NAcc (relative to cues for no incentive), in both subject groups similarly, with greatest NAcc recruitment by cues for the largest reward. Loss-anticipatory NAcc signal increase was detected in a volume-of-interest analysis - but this increase occurred only in trials when subjects hit the target. Relative to controls, AED showed significantly elevated NAcc activation by a linear contrast between reward notification versus notification of failure to win reward. In a post hoc reanalysis, VS and pregenual anterior cingulate activation by the reward versus non-reward outcome contrast also directly correlated with Child Behavior Checklist (CBCL) Externalizing total scores (across all subjects) in lieu of a binary diagnosis. Finally, both groups showed right insula activation by loss notifications (contrasted with avoided losses). Conclusions: Externalizing behavior, whether assessed dimensionally with a questionnaire, or in the form of a diagnostic categorization, is associated with an exaggerated limbic response to outcomes of reward-directed behavior. This could be a neurobiological signature of the behavioral sensitivity to laboratory reward delivery that is characteristic of children with externalizing symptomatology. Of interest is future research on incentive-motivational processing in more severe, clinically referred AED. Adapted from the source document. JF - The Journal of Child Psychology and Psychiatry AU - Bjork, James M AU - Chen, Gang AU - Smith, Ashley R AU - Hommer, Daniel W AD - Division of Clinical Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health (NIH), USA Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 827 EP - 837 PB - Blackwell Publishing, Oxford UK VL - 51 IS - 7 SN - 0021-9630, 0021-9630 KW - Conduct disorder oppositional defiant disorder externalizing disorders reward ventral striatum nucleus accumbens KW - Recruitment KW - Cues KW - Externalizing behaviour KW - Rewards KW - Notification KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839571410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=Incentive-elicited+mesolimbic+activation+and+externalizing+symptomatology+in+adolescents&rft.au=Bjork%2C+James+M%3BChen%2C+Gang%3BSmith%2C+Ashley+R%3BHommer%2C+Daniel+W&rft.aulast=Bjork&rft.aufirst=James&rft.date=2010-07-01&rft.volume=51&rft.issue=7&rft.spage=827&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Child+Psychology+and+Psychiatry&rft.issn=00219630&rft_id=info:doi/10.1111%2Fj.1469-7610.2009.02201.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JPPDAI N1 - SubjectsTermNotLitGenreText - Rewards; Externalizing behaviour; Cues; Recruitment; Adolescents; Notification DO - http://dx.doi.org/10.1111/j.1469-7610.2009.02201.x ER - TY - JOUR T1 - Concurrent validity of the parent-completed Ages and Stages Questionnaires, 2nd Ed. with the Bayley Scales of Infant Development II in a low-risk sample AN - 839571094; 201101510 AB - Background This study assessed the concurrent validity of the Ages and Stages Questionnaire (ASQ) compared with Bayley Scales of Infant Development II (BSID II) amongst children aged 24 months. Methods who participated in the New York State Angler Cohort Child Development Study. Parents completed the 24-month ASQ to assess communication, personal-social, problem-solving ability, and fine and gross motor control. The BSID II was administered by a clinical psychologist at the 24-month home visit for cognitive and psychomotor assessment. The ASQ was scored using age-specific norms of <2 SDs below any domain mean to define failure. A BSID II score of <85 indicated mild or severe delay, while a score of <70 suggested a severe delay. Results Scores on the ASQ communication and personal-social domains were moderately correlated with the BSID II Mental Scale (R = 0.52, P < 0.001; R = 0.45, P < 0.01) and ASQ gross motor with the BSID II Motor Scale (R = 0.46, P < 0.01), whereas ASQ problem-solving and fine motor domains were not significantly correlated with BSID II scores. The ASQ had a sensitivity of 100% and specificity of 87% at 24 months (n = 40) for severely delayed status. Conclusions cost-effective method for clinicians and field-based researchers to reduce the number of standardized assessments required to identify developmentally delayed infants at age 24 months. Future studies should further assess the validity of the ASQs in larger, more diverse populations of infants. Adapted from the source document. JF - Child: Care, Health and Development AU - Gollenberg, A L AU - Lynch, C D AU - Jackson, L W AU - McGuinness, B M AU - Msall, M E AD - Eunice Kennedy Shriver, National Institute of Child Health and Human Development; National Institutes of Health; Department of Health and Human Services; Rockville, MD Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 485 EP - 490 PB - Blackwell Publishing, Oxford UK VL - 36 IS - 4 SN - 0305-1862, 0305-1862 KW - child development developmental screening diagnostic tests sensitivity and specificity KW - Fines KW - Cost effectiveness KW - Problem solving KW - Child development KW - Clinical psychologists KW - Infants KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839571094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child%3A+Care%2C+Health+and+Development&rft.atitle=Concurrent+validity+of+the+parent-completed+Ages+and+Stages+Questionnaires%2C+2nd+Ed.+with+the+Bayley+Scales+of+Infant+Development+II+in+a+low-risk+sample&rft.au=Gollenberg%2C+A+L%3BLynch%2C+C+D%3BJackson%2C+L+W%3BMcGuinness%2C+B+M%3BMsall%2C+M+E&rft.aulast=Gollenberg&rft.aufirst=A&rft.date=2010-07-01&rft.volume=36&rft.issue=4&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Child%3A+Care%2C+Health+and+Development&rft.issn=03051862&rft_id=info:doi/10.1111%2Fj.1365-2214.2009.01041.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - CCHDDH N1 - SubjectsTermNotLitGenreText - Infants; Fines; Problem solving; Clinical psychologists; Cost effectiveness; Child development DO - http://dx.doi.org/10.1111/j.1365-2214.2009.01041.x ER - TY - JOUR T1 - Automatic Classification of Lymphoma Images With Transform-Based Global Features AN - 762269659; 13722927 AB - We propose a report on automatic classification of three common types of malignant lymphoma: chronic lymphocytic leukemia, follicular lymphoma, and mantle cell lymphoma. The goal was to find patterns indicative of lymphoma malignancies and allowing classifying these malignancies by type. We used a computer vision approach for quantitative characterization of image content. A unique two-stage approach was employed in this study. At the outer level, raw pixels were transformed with a set of transforms into spectral planes. Simple (Fourier, Chebyshev, and wavelets) and compound transforms (Chebyshev of Fourier and wavelets of Fourier) were computed. Raw pixels and spectral planes were then routed to the second stage (the inner level). At the inner level, the set of multipurpose global features was computed on each spectral plane by the same feature bank. All computed features were fused into a single feature vector. The specimens were stained with hematoxylin (H) and eosin (E) stains. Several color spaces were used: RGB, gray, CIE-L*a*b*, and also the specific stain-attributed H&E space, and experiments on image classification were carried out for these sets. The best signal (98%-99% on earlier unseen images) was found for the HE, H, and E channels of the H&E data set. JF - IEEE Transactions on Information Technology in Biomedicine AU - Orlov, Nikita V AU - Chen, Wayne W AU - Mark Eckley, David AU - Macura, Tomasz J AU - Shamir, Lior AU - Jaffe, Elaine S AU - Goldberg, Ilya G AD - National Institute on Aging, NIH, Baltimore, USA Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 1003 EP - 1013 PB - Institute of Electrical and Electronics Engineers, Inc., 3 Park Avenue, 17th Fl New York NY 10016-5997 USA VL - 14 IS - 4 SN - 1089-7771, 1089-7771 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Malignancy KW - mantle cell lymphoma KW - Data processing KW - Vision KW - Computers KW - Stains KW - Chronic lymphatic leukemia KW - Color KW - F 06915:Cancer Immunology KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762269659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Information+Technology+in+Biomedicine&rft.atitle=Automatic+Classification+of+Lymphoma+Images+With+Transform-Based+Global+Features&rft.au=Orlov%2C+Nikita+V%3BChen%2C+Wayne+W%3BMark+Eckley%2C+David%3BMacura%2C+Tomasz+J%3BShamir%2C+Lior%3BJaffe%2C+Elaine+S%3BGoldberg%2C+Ilya+G&rft.aulast=Orlov&rft.aufirst=Nikita&rft.date=2010-07-01&rft.volume=14&rft.issue=4&rft.spage=1003&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Information+Technology+in+Biomedicine&rft.issn=10897771&rft_id=info:doi/10.1109%2FTITB.2010.2050695 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - mantle cell lymphoma; Malignancy; Data processing; Vision; Computers; Stains; Chronic lymphatic leukemia; Color DO - http://dx.doi.org/10.1109/TITB.2010.2050695 ER - TY - JOUR T1 - Evaluation of a Library Outreach Program to Research Labs AN - 758112953; 201009512 AB - The goal of this study was to conduct an outcomes-based evaluation of the National Cancer Institute-Frederick (NCI-F) Scientific Library's Laptop Librarian service, where librarians took a laptop and spent time in research buildings. The authors used statistics from the Laptop Librarian sessions, a NCI-F community-wide online survey, and in-person interviews to evaluate the service. The Laptop Librarian service increased the accessibility of librarians and saved patrons' time. Users gained useful information and expressed overall satisfaction with the service. The Laptop Librarian service proves to be a useful means for increasing access to librarians and providing users with necessary information at this government research facility. Adapted from the source document. JF - Medical Reference Services Quarterly AU - Brandenburg, Marci D AU - Doss, Alan AU - Frederick, Tracie E AD - Wilson Information Services Corporation, National Cancer Institute-Frederick, P.O. Box B, Bldg. 549, Sultan Street, Frederick, MD 21702-1201 brandenburgm@mail.nih.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 249 EP - 259 PB - Taylor & Francis, Philadelphia PA VL - 29 IS - 3 SN - 0276-3869, 0276-3869 KW - Government libraries, Laptop Librarian service, library outreach, outcomes-based evaluation, outreach services, research libraries KW - Laptop computers KW - Research libraries KW - Government libraries KW - Outreach services KW - article KW - 4.15: USER SERVICES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758112953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Reference+Services+Quarterly&rft.atitle=Evaluation+of+a+Library+Outreach+Program+to+Research+Labs&rft.au=Brandenburg%2C+Marci+D%3BDoss%2C+Alan%3BFrederick%2C+Tracie+E&rft.aulast=Brandenburg&rft.aufirst=Marci&rft.date=2010-07-01&rft.volume=29&rft.issue=3&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Medical+Reference+Services+Quarterly&rft.issn=02763869&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2010-10-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Outreach services; Laptop computers; Government libraries; Research libraries ER - TY - JOUR T1 - Characterizations and validations of novel antibodies toward translational research AN - 754898113; 13547792 AB - Purpose: There is significant need for well-characterized antibodies to the spectrum of human proteins encoded by the genome. Advances in tissue-based proteomic profiling have led to the discovery of many candidate molecular biomarkers and therapeutic targets for which development of clinical assays is depending on high quality antibodies. We developed an antibody validation approach for screening of new mAbs. Experimental design: We utilized a multi-stage approach of protein array and immunohistochemistry. In the first phase, we screened the NCI60 panel of cell lines by means of protein array and select antibodies based on concordance of mRNA expression to protein array signal. Results of this assay are used to predict antibody titer for immunohistochemistry on the NCI60 cell lines, presented as a tissue microarray. In the final stage, we created a tissue-based protein expression map by performing immunohistochemistry on a multi-tumor tissue microarray. Results: The success rate of this systematic antibody-screening tool was approximately 93% as measured by the results from the protein array. Data from the NCI60 protein array could be used to predict antibody titer for immunohistochemistry, improving the success rate of immunohistochemical assay development. Conclusions and clinical relevance: The presented strategy of antibody validation and characterization can be provided a new tool for exploration of human proteome. JF - Proteomics Clinical Applications AU - Williams, R AU - Chung, J-Y AU - Ylaya, K AU - Whiteley, G AU - Hewitt, S M AD - TARP Lab, Advanced Technology Center, MSC 4605, Bethesda, MD, 20892-4605 USA, genejock@helix.nih.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 618 EP - 625 VL - 4 IS - 6-7 SN - 1862-8346, 1862-8346 KW - Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Genomes KW - Translation KW - Antibodies KW - Data processing KW - Monoclonal antibodies KW - Protein arrays KW - Therapeutic applications KW - proteomics KW - Immunohistochemistry KW - biomarkers KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754898113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics+Clinical+Applications&rft.atitle=Characterizations+and+validations+of+novel+antibodies+toward+translational+research&rft.au=Williams%2C+R%3BChung%2C+J-Y%3BYlaya%2C+K%3BWhiteley%2C+G%3BHewitt%2C+S+M&rft.aulast=Williams&rft.aufirst=R&rft.date=2010-07-01&rft.volume=4&rft.issue=6-7&rft.spage=618&rft.isbn=&rft.btitle=&rft.title=Proteomics+Clinical+Applications&rft.issn=18628346&rft_id=info:doi/10.1002%2Fprca.200900186 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Genomes; Gene expression; Translation; Antibodies; Data processing; Monoclonal antibodies; Protein arrays; Therapeutic applications; proteomics; biomarkers; Immunohistochemistry DO - http://dx.doi.org/10.1002/prca.200900186 ER - TY - JOUR T1 - Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids AN - 754868926; 13214306 AB - Five new naphthopyrones ( 1- 5) along with the known compounds TMC-256A1, 5,8-dihydroxy-6-methoxy-2-propyl-4H-naphtho[2,3-b]pyran-4-o ne, TMC-256C1, comaparvin, 6-methoxycomaparvin, and 6-methoxycomaparvin 5-methyl ether ( 6- 11) were isolated from crinoids of the family Comasteridae. All compounds were tested for their ability to inhibit the multidrug transporter ABCG2, which plays a role in drug resistance. Six of the seven angular naphthopyrones showed moderate activity with <60% inhibition of ABCG2-mediated transport as compared to the positive control fumitremorgin C. None of the linear naphthopyrones inhibited ABCG2-mediated efflux. JF - Bioorganic and Medicinal Chemistry Letters AU - Bokesch, Heidi R AU - Cartner, Laura K AU - Fuller, Richard W AU - Wilson, Jennifer A AU - Henrich, Curtis J AU - Kelley, James A AU - Gustafson, Kirk R AU - McMahon, James B AU - McKee, Tawnya C AD - Molecular Targets Laboratory, NCI-Frederick, Frederick, MD 21702, USA, mckeeta@mail.nih.gov Y1 - 2010/07/01/ PY - 2010 DA - 2010 Jul 01 SP - 3848 EP - 3850 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 20 IS - 13 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - Comasteridae KW - Drug resistance KW - Ethers KW - Drugs KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754868926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Inhibition+of+ABCG2-mediated+drug+efflux+by+naphthopyrones+from+marine+crinoids&rft.au=Bokesch%2C+Heidi+R%3BCartner%2C+Laura+K%3BFuller%2C+Richard+W%3BWilson%2C+Jennifer+A%3BHenrich%2C+Curtis+J%3BKelley%2C+James+A%3BGustafson%2C+Kirk+R%3BMcMahon%2C+James+B%3BMcKee%2C+Tawnya+C&rft.aulast=Bokesch&rft.aufirst=Heidi&rft.date=2010-07-01&rft.volume=20&rft.issue=13&rft.spage=3848&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2010.05.057 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Drug resistance; Ethers; Drugs; Comasteridae DO - http://dx.doi.org/10.1016/j.bmcl.2010.05.057 ER - TY - JOUR T1 - Pseudomonas Exotoxin A-Mediated Apoptosis Is Bak Dependent and Preceded by the Degradation of Mcl-1 AN - 754868779; 13209929 AB - Pseudomonas exotoxin A (PE) is a bacterial toxin that arrests protein synthesis and induces apoptosis. Here, we utilized mouse embryo fibroblasts (MEFs) deficient in Bak and Bax to determine the roles of these proteins in cell death induced by PE. PE induced a rapid and dose-dependent induction of apoptosis in wild-type (WT) and Bax knockout (Bax-/-) MEFs but failed in Bak knockout (Bak-/-) and Bax/Bak double-knockout (DKO) MEFs. Also a loss of mitochondrial membrane potential was observed in WT and Bax-/- MEFs, but not in Bak-/- or in DKO MEFs, indicating an effect of PE on mitochondrial permeability. PE-mediated inhibition of protein synthesis was identical in all 4 cell lines, indicating that differences in killing were due to steps after the ADP-ribosylation of EF2. Mcl-1, but not Bcl-xL, was rapidly degraded after PE treatment, consistent with a role for Mcl-1 in the PE death pathway. Bak was associated with Mcl-1 and Bcl-xL in MEFs and uncoupled from suppressed complexes after PE treatment. Overexpression of Mcl-1 and Bcl-xL inhibited PE-induced MEF death. Our data suggest that Bak is the preferential mediator of PE-mediated apoptosis and that the rapid degradation of Mcl-1 unleashes Bak to activate apoptosis. JF - Molecular and Cellular Biology AU - Du, Xing AU - Youle, Richard J AU - FitzGerald, David J AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, pastani@mail.nih.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 3444 EP - 3452 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 30 IS - 14 SN - 0270-7306, 0270-7306 KW - Microbiology Abstracts B: Bacteriology KW - Data processing KW - Protein biosynthesis KW - Apoptosis KW - Mitochondria KW - Membrane permeability KW - Pseudomonas KW - exotoxin A KW - Exotoxins KW - Toxins KW - Bcl-x protein KW - Bax protein KW - Mcl-1 protein KW - Embryo fibroblasts KW - BAK protein KW - ADP-ribosylation KW - Membrane potential KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754868779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=Pseudomonas+Exotoxin+A-Mediated+Apoptosis+Is+Bak+Dependent+and+Preceded+by+the+Degradation+of+Mcl-1&rft.au=Du%2C+Xing%3BYoule%2C+Richard+J%3BFitzGerald%2C+David+J%3BPastan%2C+Ira&rft.aulast=Du&rft.aufirst=Xing&rft.date=2010-07-01&rft.volume=30&rft.issue=14&rft.spage=3444&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Biology&rft.issn=02707306&rft_id=info:doi/10.1128%2FMCB.00813-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Apoptosis; Protein biosynthesis; Data processing; Membrane permeability; Mitochondria; exotoxin A; Toxins; Exotoxins; Bcl-x protein; Mcl-1 protein; Bax protein; Embryo fibroblasts; BAK protein; ADP-ribosylation; Membrane potential; Pseudomonas DO - http://dx.doi.org/10.1128/MCB.00813-09 ER - TY - JOUR T1 - Exercise Capacity and Idebenone Intervention in Children and Adolescents With Friedreich Ataxia AN - 754566527; 13406259 AB - Drinkard BE, Keyser RE, Paul SM, Arena R, Plehn JF, Yanovski JA, di Prospero NA. Exercise capacity and idebenone intervention in children and adolescents with Friedreich ataxia. Objective - To determine the exercise capacity of children and adolescents with Friedreich's Ataxia (FA) and to evaluate the effects of 6 months of idebenone treatment on exercise capacity. Design - Exploratory endpoint in a randomized double-blind, placebo-controlled, phase II clinical trial designed to investigate the effects of idebenone on a biomarker of oxidative stress. Setting - Exercise physiology laboratory in a single clinical research center. Participants - Ambulatory subjects (N=48; age range, 9-17y) with genetically confirmed FA. Intervention - Idebenone administered orally 3 times a day for a total daily dose of approximately 5, 15, and 45mg/kg or matching placebo for 6 months. Main Outcome Measures - Peak oxygen consumption per unit time (peak VO sub(2)) and peak work rate (WR) were measured during incremental exercise testing at baseline and after treatment. Echocardiography and neurologic assessments were also completed before and after treatment. Results - Baseline mean peak VO sub(2) +/- SD was 746+/-246mL/min (16.2+/-5.8mL/kg/min), and WR was 40+/-23W for all subjects. Peak VO sub(2) and WR were correlated with short guanine-adenine-adenine allele length and neurologic function. Relative left ventricular wall thickness was increased but left ventricular ejection fraction was normal in most subjects; there was no relationship between any exercise and echocardiographic measures. There were no significant changes in mean peak VO sub(2) or WR after idebenone treatment at any dose level relative to placebo. Conclusions - Exercise capacity in children and adolescents with FA was significantly impaired. The basis for the impairment appears to be multifactorial and correlated to the degree of neurologic impairment. Although idebenone has previously been shown potentially to improve features of FA, idebenone treatment did not increase exercise capacity relative to placebo. JF - Archives of Physical Medicine and Rehabilitation AU - Drinkard, Bart E AU - Keyser, Randall E AU - Paul, Scott M AU - Arena, Ross AU - Plehn, Jonathan F AU - Yanovski, Jack A AU - Di Prospero, Nicholas A AD - Rehabilitation Medicine Department, Hatfield Clinical Research Center, National Institutes of Health, Bethesda, MD, Bart_Drinkard@nih.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 1044 EP - 1050 PB - Elsevier BV, The Curtis Center, Independence Square West Philadelphia PA 19106-3399 USA VL - 91 IS - 7 SN - 0003-9993, 0003-9993 KW - CSA Neurosciences Abstracts; Physical Education Index KW - Adolescence KW - Exercise physiology KW - Physical training KW - PE 090:Sports Medicine & Exercise Sport Science KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754566527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=Exercise+Capacity+and+Idebenone+Intervention+in+Children+and+Adolescents+With+Friedreich+Ataxia&rft.au=Drinkard%2C+Bart+E%3BKeyser%2C+Randall+E%3BPaul%2C+Scott+M%3BArena%2C+Ross%3BPlehn%2C+Jonathan+F%3BYanovski%2C+Jack+A%3BDi+Prospero%2C+Nicholas+A&rft.aulast=Drinkard&rft.aufirst=Bart&rft.date=2010-07-01&rft.volume=91&rft.issue=7&rft.spage=1044&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=00039993&rft_id=info:doi/10.1016%2Fj.apmr.2010.04.007 LA - English DB - Physical Education Index N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Exercise physiology; Physical training DO - http://dx.doi.org/10.1016/j.apmr.2010.04.007 ER - TY - JOUR T1 - Structure and Molecular Characterization of Streptococcus pneumoniae Capsular Polysaccharide 10F by Carbohydrate Engineering in Streptococcus oralis AN - 754562625; 13370358 AB - Although closely related at the molecular level, the capsular polysaccharide (CPS) of serotype 10F Streptococcus pneumoniae and coaggregation receptor polysaccharide (RPS) of Streptococcus oralis C104 have distinct ecological roles. CPS prevents phagocytosis of pathogenic S. pneumoniae, whereas RPS of commensal S. oralis functions as a receptor for lectin-like adhesins on other members of the dental plaque biofilm community. Results from high resolution NMR identified the recognition region of S. oralis RPS (i.e. Galfb1-6GalNAcb1-3Gala) in the hexasaccharide repeat of S. pneumoniae CPS10F. The failure of this polysaccharide to support fimbriae-mediated adhesion of Actinomyces naeslundii was explained by the position of Galf, which occurred as a branch in CPS10F rather than within the linear polysaccharide chain, as in RPS. Carbohydrate engineering of S. oralis RPS with wzy from S. pneumoniae attributed formation of the Galf branch in CPS10F to the linkage of adjacent repeating units through sub terminal GalNAc in Galfb1-6GalNAcb1-3Gala rather than through terminal Galf, as in RPS. A gene (wcrD) from serotype 10A S. pneumoniae was then used to engineer a linear surface polysaccharide in S. oralis that was identical to RPS except for the presence of a b1-3 linkage between Galf and GalNAcb1-3Gala. This polysaccharide also failed to support adhesion of A. naeslundii, thereby establishing the essential role of b1-6-linked Galf in recognition of adjacent GalNAcb1-3Gala in wild-type RPS. These findings, which illustrate a molecular approach for relating bacterial polysaccharide structure to function, provide insight into the possible evolution of S. oralis RPS from S. pneumoniae CPS. JF - Journal of Biological Chemistry AU - Yang, Jinghua AU - Shelat, Nirav Y AU - Bush, CAllen AU - Cisar, John O AD - Oral Infection and Immunity Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, the Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250 Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 24217 EP - 24227 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 285 IS - 31 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Adhesins KW - Serotypes KW - Commensals KW - Dental plaque KW - Actinomyces naeslundii KW - Streptococcus pneumoniae KW - Structure-function relationships KW - N.M.R. KW - Carbohydrates KW - Biofilms KW - Phagocytosis KW - Capsular polysaccharides KW - Evolution KW - Streptococcus oralis KW - J 02310:Genetics & Taxonomy KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754562625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Structure+and+Molecular+Characterization+of+Streptococcus+pneumoniae+Capsular+Polysaccharide+10F+by+Carbohydrate+Engineering+in+Streptococcus+oralis&rft.au=Yang%2C+Jinghua%3BShelat%2C+Nirav+Y%3BBush%2C+CAllen%3BCisar%2C+John+O&rft.aulast=Yang&rft.aufirst=Jinghua&rft.date=2010-07-01&rft.volume=285&rft.issue=31&rft.spage=24217&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M110.123562 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Adhesins; Serotypes; Structure-function relationships; Commensals; N.M.R.; Biofilms; Carbohydrates; Dental plaque; Phagocytosis; Capsular polysaccharides; Evolution; Streptococcus pneumoniae; Actinomyces naeslundii; Streptococcus oralis DO - http://dx.doi.org/10.1074/jbc.M110.123562 ER - TY - JOUR T1 - Follicular dendritic cell sarcoma of the neck: case report and review of current diagnostic and management strategies. AN - 754147562; pmid-20628972 AB - Follicular dendritic cell sarcoma (FDCS) is a rare malignant neoplasm that can clinically mimic a number of other tumors. FDCS can follow either an indolent or aggressive course. The prognosis tends to be worse for patients with large or high-grade tumors and/or an intra-abdominal tumor site. For optimal management, complete surgical excision is recommended. Radiation therapy and/or chemotherapy may be considered for incompletely resected tumors and for tumors with poor prognostic features, but the exact role of adjuvant therapy is unknown. We report a case of cervical FDCS in a 39-year-old black man, and we review the presentation and management of this disorder, with emphasis on the differential diagnosis. JF - Ear, nose, & throat journal AU - Amiri-Kordestani, Laleh AU - Priebat, Dennis AU - Chia, Stanley H AD - Department of Medical Oncology, National Cancer Institute, Bethesda, MD, USA. Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - E14 EP - E17 VL - 89 IS - 7 SN - 0145-5613, 0145-5613 KW - Index Medicus KW - National Library of Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754147562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear%2C+nose%2C+%26+throat+journal&rft.atitle=Follicular+dendritic+cell+sarcoma+of+the+neck%3A+case+report+and+review+of+current+diagnostic+and+management+strategies.&rft.au=Amiri-Kordestani%2C+Laleh%3BPriebat%2C+Dennis%3BChia%2C+Stanley+H&rft.aulast=Amiri-Kordestani&rft.aufirst=Laleh&rft.date=2010-07-01&rft.volume=89&rft.issue=7&rft.spage=E14&rft.isbn=&rft.btitle=&rft.title=Ear%2C+nose%2C+%26+throat+journal&rft.issn=01455613&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-07-22 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Diffusion tensor imaging in Alzheimer's dementia and APOE-epsilon4 status AN - 754141169; 201024372 AB - Background: Previous studies in Alzheimer's dementia (AD) using Diffusion tensor Imaging (DTI) by region of interest based approach noted regional abnormalities in white matter of temporal, frontal and parietal lobes. Apolipoprotein E4 (apoE4) gene polymorphism is a genetic risk factor for development of cognitive impairment and dementia.The knowledge about the associated structural brain change by which this genetic variation influences the clinical presentation is limited. Methods: We used DTI to compare brain white matter changes in subjects. Twenty-four patients with probable AD according to NINCDS/ADRDA AD criteria attending NIMHANS and fourteen matched healthy controls formed the subjects. Among the subjects 11 patients with AD and 6 healthy controls were apoE4 carriers. All subjects were right handed and evaluated in detail clinically to arrive at diagnosis. Clinical Dementia rating scale (Morris et al 1993), Cognitive Screening Battery (Ganguly et al 1996), Everyday Abilities Scale for India (Fillenbaum et al 1999) was administered on subjects.Ten ml of venous blood was collected, genomic DNA extracted, and genotyping done at apolipoprotein-E locus according to standard procedure. The DTI images were obtained on the Philips 3T Archieva MRI scanner. Fractional Anisotropy (FA) maps were extracted using FSL-FDT software package. Voxel based morphometric (VBM) analysis was performed on the FA maps using study specific custom template by applying two sample t-test, at significance level of p = 0.001 with threshold masking of 0.2 on white matter segmented FA maps using Statistical Parametric Mapping (SPM) 5 version. Results: Between patients with AD and controls the areas of significant difference was noticed in bilateral temporal lobes, bilateral limbic lobe, Left insula, uncus, amygdala & parahippocampal regions and Right posterior cingulate region. Bilateral temporal lobe and right subgyral parietal lobe area was differing between APOE e4 carrier and non-carrier AD patients. Conclusions: Patients with AD have abnormalities in white matter tracts in regions of temporal lobe compared to controls. Apo E4 carrier status is associated with structural changes in white matter integrity in patients with AD. Findings indicate the need for further study using VBM approach in white matter tracts of patients with AD and apoE4 allele. [Copyright Elsevier B.V.] JF - Alzheimer's & Dementia AU - Bagepally, Bhavani Shankara AU - John, John P AU - Kovoor, Jerry M E AU - Purushottam, Meera AU - Mukherjee, Odity AU - Kota, Lakshminarayanan AU - Sadananda, Shilpa AU - Prakash, Om AU - Thangaraju, Sivakumar Palanimuthu AU - Srikala, Bharath AU - Jain, Sanjeev AU - Varghese, Mathew AD - National Institute of Mental Health and Neurosciences, Bangalore, India Y1 - 2010/07// PY - 2010 DA - July 2010 SP - S18 EP - S19 PB - Elsevier Ltd, The Netherlands VL - 6 IS - 4S1 SN - 1552-5260, 1552-5260 KW - Clinical assessment KW - Diffusion tensor imaging KW - Carriers KW - Alzheimer's disease KW - Maps KW - Temporal lobes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754141169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alzheimer%27s+%26+Dementia&rft.atitle=Diffusion+tensor+imaging+in+Alzheimer%27s+dementia+and+APOE-epsilon4+status&rft.au=Bagepally%2C+Bhavani+Shankara%3BJohn%2C+John+P%3BKovoor%2C+Jerry+M+E%3BPurushottam%2C+Meera%3BMukherjee%2C+Odity%3BKota%2C+Lakshminarayanan%3BSadananda%2C+Shilpa%3BPrakash%2C+Om%3BThangaraju%2C+Sivakumar+Palanimuthu%3BSrikala%2C+Bharath%3BJain%2C+Sanjeev%3BVarghese%2C+Mathew&rft.aulast=Bagepally&rft.aufirst=Bhavani&rft.date=2010-07-01&rft.volume=6&rft.issue=4S1&rft.spage=S18&rft.isbn=&rft.btitle=&rft.title=Alzheimer%27s+%26+Dementia&rft.issn=15525260&rft_id=info:doi/10.1016%2Fj.jalz.2010.05.051 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-09-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Alzheimer's disease; Carriers; Temporal lobes; Maps; Clinical assessment; Diffusion tensor imaging DO - http://dx.doi.org/10.1016/j.jalz.2010.05.051 ER - TY - JOUR T1 - Bullying Victimization Among Underweight and Overweight U.S. Youth: Differential Associations for Boys and Girls AN - 754141060; 201023948 AB - To examine the associations between body weight and physical, verbal, relational, and cyber victimization among U.S. boys and girls in grade 6 through 10. Underweight boys and girls were more likely to be physical and relational victims, respectively. Overweight boys and obese girls were more likely to be verbal victims. [Copyright The Society for Adolescent Medicine; published by Elsevier Inc.] JF - Journal of Adolescent Health AU - Wang, Jing AU - Iannotti, Ronald J AU - Luk, Jeremy W AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland wangji2@mail.nih.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 99 EP - 101 PB - Elsevier, New York NY VL - 47 IS - 1 SN - 1054-139X, 1054-139X KW - Victimization Body weight Gender difference Youth KW - Obesity KW - Body weight KW - Victims KW - Underweight KW - Bullying KW - Victimization KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754141060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=Bullying+Victimization+Among+Underweight+and+Overweight+U.S.+Youth%3A+Differential+Associations+for+Boys+and+Girls&rft.au=Wang%2C+Jing%3BIannotti%2C+Ronald+J%3BLuk%2C+Jeremy+W&rft.aulast=Wang&rft.aufirst=Jing&rft.date=2010-07-01&rft.volume=47&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/10.1016%2Fj.jadohealth.2009.12.007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JAHCD9 N1 - SubjectsTermNotLitGenreText - Obesity; Victims; Underweight; Victimization; Bullying; Body weight DO - http://dx.doi.org/10.1016/j.jadohealth.2009.12.007 ER - TY - JOUR T1 - Childhood sexual abuse and attachment: An intergenerational perspective AN - 754138570; 201021959 AB - Childhood sexual abuse (CSA) is a recognized risk factor for various negative outcomes in adult survivors and their offspring. We used the Dynamic-Maturational Model of attachment theory as a framework for exploring the impact of maternal CSA on children's attachment relationships in the context of a longitudinal sample of adult survivors of CSA and non-abused comparison mothers and their children. Results indicated that children of CSA survivors were more likely to have extreme strategies of attachment than the children of non-abused mothers. However, because both groups were at socioeconomic risk, both were typified by anxious attachment. Explanations for findings and implications for children's development are explored. [Copyright Sage Publications Ltd.] JF - Clinical Child Psychology and Psychiatry AU - Kwako, Laura E AU - Noll, Jennie G AU - Putnam, Frank W AU - Trickett, Penelope K AD - National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA kwako.laura@gmail.com Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 407 EP - 422 PB - Sage Publications, London UK VL - 15 IS - 3 SN - 1359-1045, 1359-1045 KW - attachment childhood sexual abuse intergenerational KW - Anxious attachment KW - Attachment KW - Mothers KW - Childhood sexual abuse KW - Children KW - Survivors KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754138570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Child+Psychology+and+Psychiatry&rft.atitle=Childhood+sexual+abuse+and+attachment%3A+An+intergenerational+perspective&rft.au=Kwako%2C+Laura+E%3BNoll%2C+Jennie+G%3BPutnam%2C+Frank+W%3BTrickett%2C+Penelope+K&rft.aulast=Kwako&rft.aufirst=Laura&rft.date=2010-07-01&rft.volume=15&rft.issue=3&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Clinical+Child+Psychology+and+Psychiatry&rft.issn=13591045&rft_id=info:doi/10.1177%2F1359104510367590 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Attachment; Survivors; Children; Childhood sexual abuse; Mothers; Anxious attachment DO - http://dx.doi.org/10.1177/1359104510367590 ER - TY - JOUR T1 - Impaired probabilistic reversal learning in youths with mood and anxiety disorders AN - 754135969; 201020610 AB - From an affective neuroscience perspective, our understanding of psychiatric illness may be advanced by neuropsychological test paradigms probing emotional processes. Reversal learning is one such process, whereby subjects must first acquire stimulus/reward and stimulus/punishment associations through trial and error and then reverse them. We sought to determine the specificity of previously demonstrated reversal learning impairments in youths with bipolar disorder (BD) by now comparing BD youths to those with severe mood dysregulation (SMD), major depressive disorder (MDD), anxiety (ANX), and healthy controls. We administered the probabilistic response reversal (PRR) task to 165 pediatric participants aged 7-17 years with BD (n=35), SMD (n=35), ANX (n=42), MDD (n=18) and normal controls (NC; n=35). Our primary analysis compared PRR performance across all five groups matched for age, sex and IQ. Compared to typically developing controls, probabilistic reversal learning was impaired in BD youths, with a trend in those with MDD (p=0.07). Our results suggest that reversal learning deficits are present in youths with BD and possibly those with MDD. Further work is necessary to elucidate the specificity of neural mechanisms underlying such behavioral deficits. Adapted from the source document. JF - Psychological Medicine AU - Dickstein, D P AU - Finger, E C AU - Brotman, M A AU - Rich, B A AU - Pine, D S AU - Blair, J R AU - Leibenluft, E AD - National Institute of Mental Health (NIMH) Mood and Anxiety Disorders Program Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 1089 EP - 1100 PB - Cambridge University Press, UK VL - 40 IS - 7 SN - 0033-2917, 0033-2917 KW - Depressive personality disorders KW - Paediatrics KW - Learning KW - Stimulus KW - Young people KW - Reversal KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754135969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Impaired+probabilistic+reversal+learning+in+youths+with+mood+and+anxiety+disorders&rft.au=Dickstein%2C+D+P%3BFinger%2C+E+C%3BBrotman%2C+M+A%3BRich%2C+B+A%3BPine%2C+D+S%3BBlair%2C+J+R%3BLeibenluft%2C+E&rft.aulast=Dickstein&rft.aufirst=D&rft.date=2010-07-01&rft.volume=40&rft.issue=7&rft.spage=1089&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291709991462 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Reversal; Young people; Learning; Depressive personality disorders; Stimulus; Paediatrics DO - http://dx.doi.org/10.1017/S0033291709991462 ER - TY - JOUR T1 - Yanukovych and Ukraine's Foreign Policy: Back to a More Balanced Position? TT - Ianoukovitch et la politique etrangere ukrainienne: retour a l'equilibre? AN - 754064953; 201050541 AB - Bettering relations with Moscow is one of the new Ukrainian president's foreign policy priorities. Recently reached agreements relative to gaz & Russia's Crimean fleet are a testament to this commitment. Notwithstanding, Kiev has stated that its foreign policy is no longer a question of East & West; further, enhanced relations with the EU will serve to balance Moscow's weight. Fine-tuning this new balance may be tricky, however, due to divisions within the Ukrainian political world. Adapted from the source document. JF - Politique etrangere AU - Fean, Dominic AD - Centre Russie/NEI, Ifri Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 413 EP - 426 PB - IFRI, Paris France IS - 2 SN - 0032-342X, 0032-342X KW - European Union KW - Presidents KW - Ukraine KW - Russia KW - Foreign Policy KW - article KW - 9063: international relations; international relations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754064953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Politique+etrangere&rft.atitle=Yanukovych+and+Ukraine%27s+Foreign+Policy%3A+Back+to+a+More+Balanced+Position%3F&rft.au=Fean%2C+Dominic&rft.aulast=Fean&rft.aufirst=Dominic&rft.date=2010-07-01&rft.volume=&rft.issue=2&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Politique+etrangere&rft.issn=0032342X&rft_id=info:doi/ LA - French DB - Worldwide Political Science Abstracts N1 - Date revised - 2010-09-10 N1 - SuppNotes - Translated by Gregory Danel. N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Foreign Policy; Presidents; European Union; Russia; Ukraine ER - TY - JOUR T1 - Waiting is the hardest part: Anticipating medical test results affects processing and recall of important information AN - 753992047; 201009535 AB - Waiting for medical test results that signal physical harm can be a stressful and potentially psychologically harmful experience. Despite this, interventionists and physicians often use this wait time to deliver behavior change messages and other important information about the test, possible results and its implications. This study examined how 'bracing' for a medical test result impacts cognitive processing, as well as recall of information delivered during this period. Healthy U.S. university students (N = 150) were tested for a deficiency of a fictitious saliva biomarker that was said to be predictive of long-term health problems using a 2 (Test Result) X 2 (Expected immediacy of result: 10 min, 1 month) factorial design. Participants expecting to get the test result shortly should have been bracing for the result. While waiting for the test results participants completed measures of cognitive processing. After participants received the test result, recall of information about the biomarker was tested in addition to cognitive measures. One week later, participants who were originally told they did not have the deficiency had their recall assessed again. Results showed that anticipating an imminent test result increased cognitive distraction in the processing of information and lowered recall of information about the test and the biomarker. These results suggest that delivering critical information to patients after administering a test and immediately before giving the results may not be optimal. [Copyright Elsevier Ltd.] JF - Social Science & Medicine AU - Portnoy, David B AD - Center for Health, Intervention, and Prevention, University of Connecticut, Storrs, CT, USA portnoydb@mail.nih.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 421 EP - 428 PB - Elsevier Science, Amsterdam The Netherlands VL - 71 IS - 2 SN - 0277-9536, 0277-9536 KW - USA Experiment Medical testing Bracing Distraction Medical test results Recall KW - Prediction KW - Behavior Modification KW - Health Problems KW - College Students KW - Physicians KW - Patients KW - Medicine KW - Cognition KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753992047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Waiting+is+the+hardest+part%3A+Anticipating+medical+test+results+affects+processing+and+recall+of+important+information&rft.au=Portnoy%2C+David+B&rft.aulast=Portnoy&rft.aufirst=David&rft.date=2010-07-01&rft.volume=71&rft.issue=2&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2010.04.012 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 31 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Cognition; Medicine; College Students; Health Problems; Prediction; Patients; Physicians; Behavior Modification DO - http://dx.doi.org/10.1016/j.socscimed.2010.04.012 ER - TY - JOUR T1 - Semantic Search Engines Mean Well AN - 753821764; 201008997 AB - Semantic search, defined as a search, a question, or a click that generates meaningful results, has the potential to revolutionize the world of search. With semantic search, the burden of thinking up synonyms and related terms is transferred from a human being to a computer. The recent Web 2.0 social content, folksonomies, tagging, and communities represent not only semantic searching but also content creation, indexing, cataloging, and classification of the people, by the people, and for the people. One application where semantic searching can be particularly useful is in providing health information for the public. A number of search engines such as Yahoo!, Google, Ask, and Bing Yahoo! are now adding more powerful semantic search capabilities to harness the enormous information found in the open web. In addition, new "pure" semantic search engines continue to appear and generate significant interest, especially in areas such as health and news. Adapted from the source document. JF - Online AU - Doszkocs, Tamas AD - National Library of Medicine doszkocs@nlm.nih.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 36 EP - 42 PB - Information Today Inc, Medford, NJ VL - 34 IS - 4 SN - 0146-5422, 0146-5422 KW - Search engines KW - Semantic web KW - Semantics KW - article KW - 13.14: INFORMATION STORAGE AND RETRIEVAL - SEARCHING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753821764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Online&rft.atitle=Semantic+Search+Engines+Mean+Well&rft.au=Doszkocs%2C+Tamas&rft.aulast=Doszkocs&rft.aufirst=Tamas&rft.date=2010-07-01&rft.volume=34&rft.issue=4&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Online&rft.issn=01465422&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2010-09-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Search engines; Semantics; Semantic web ER - TY - JOUR T1 - Effect of hydrolysis on identifying prenatal cannabis exposure AN - 753653176; 13324841 AB - Abstract not available. JF - Analytical and Bioanalytical Chemistry AU - Gray, Teresa R AU - Barnes, Allan J AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd. Suite 200, Room 05A721A, Baltimore, MD, USA, mhuestis@intra.nida.nih.gov PY - 2010 SP - 2335 EP - 2347 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 397 IS - 6 SN - 1618-2642, 1618-2642 KW - Water Resources Abstracts; Aqualine Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Exposure KW - Cannabis KW - Hydrolysis KW - AQ 00001:Water Resources and Supplies KW - Q2 09183:Physics and chemistry KW - SW 3030:Effects of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753653176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Effect+of+hydrolysis+on+identifying+prenatal+cannabis+exposure&rft.au=Gray%2C+Teresa+R%3BBarnes%2C+Allan+J%3BHuestis%2C+Marilyn+A&rft.aulast=Gray&rft.aufirst=Teresa&rft.date=2010-07-01&rft.volume=397&rft.issue=6&rft.spage=2335&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-010-3772-y L2 - http://www.springerlink.com/content/w37247645x18h702/?p=0ec5d51c5ded48dab9d60a00bb3f210b&pi=35 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Hydrolysis; Exposure; Cannabis DO - http://dx.doi.org/10.1007/s00216-010-3772-y ER - TY - JOUR T1 - Skin Diseases Clinical Trials Roundtable Summary AN - 749619422 JF - Dermatology Nursing AU - Anonymous Y1 - 2010///Jul/Aug PY - 2010 DA - Jul/Aug 2010 SP - 36 EP - 37 CY - Pitman PB - Anthony J. Jannetti, Inc. VL - 22 IS - 4 SN - 10603441 KW - Medical Sciences--Dermatology And Venereology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/749619422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Dermatology+Nursing&rft.atitle=Skin+Diseases+Clinical+Trials+Roundtable+Summary&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-07-01&rft.volume=22&rft.issue=4&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Dermatology+Nursing&rft.issn=10603441&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Anthony J. Jannetti, Inc. Jul/Aug 2010 N1 - Last updated - 2014-05-18 ER - TY - JOUR T1 - RECONSTRUCTION OF RADIATION DOSES IN A CASE-CONTROL STUDY OF THYROID CANCER FOLLOWING THE CHERNOBYL ACCIDENT AN - 746309426; 13196306 AB - A population-based case-control study of thyroid cancer was carried out in contaminated regions of Belarus and Russia among persons who were exposed during childhood and adolescence to fallout from the Chernobyl accident. For each study subject, individual thyroid doses were reconstructed for the following pathways of exposure: (1) intake of super(131)I via inhalation and ingestion; (2) intake of short-lived radioiodines ( super(132)I, super(133)I, and super(135)I) and radiotelluriums ( super(131m)Te, super(132)Te) via inhalation and ingestion; (3) external dose from radionuclides deposited on the ground; and (4) ingestion of super(134)Cs and super(137)Cs. A series of intercomparison exercises validated the models used for reconstruction of average doses to populations of specific age groups as well as of individual doses. Median thyroid doses from all factors for study subjects were estimated to be 0.37 and 0.034 Gy in Belarus and Russia, respectively. The highest individual thyroid doses among the subjects were 10.2 Gy in Belarus and 5.3 Gy in Russia. Iodine-131 intake was the main pathway for thyroid exposure. Estimated doses from short-lived radioiodines and radiotelluriums ranged up to 0.53 Gy. Reconstructed individual thyroid doses from external exposure ranged up to 0.1 Gy, while those from internal exposure due to ingested cesium did not exceed 0.05 Gy. The uncertainty of the reconstructed individual thyroid doses, characterized by the geometric standard deviation, varies from 1.7 to 4.0 with a median of 2.2. JF - Health Physics AU - Drozdovitch, V AU - Khrouch, V AU - Maceika, E AU - Zvonova, I AU - Vlasov, O AU - Bratilova, A AU - Gavrilin, Y AU - Goulko, G AU - Hoshi, M AU - Kesminiene, A AU - Shinkarev, S AU - Tenet, V AU - Cardis, E AU - Bouville, A AD - DHHS/NIH/NCI/Division of Cancer Epidemiology and Genetics, 6120 Executive Blvd, EPS-7100, Bethesda, MD 20892, USA, drozdovv@mail.nih.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 1 EP - 16 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 99 IS - 1 SN - 0017-9078, 0017-9078 KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Belarus KW - Inhalation KW - Ukraine, Chernobyl KW - Age KW - Cesium KW - Models KW - Fallout KW - Accidents KW - thyroid cancer KW - Adolescents KW - age groups KW - Adolescence KW - Thyroid KW - Ingestion KW - Children KW - Cancer KW - Physical training KW - Nuclear power plants KW - Standard deviation KW - Radioactive fallout KW - Radioisotopes KW - Russia KW - X 24390:Radioactive Materials KW - H 8000:Radiation Safety/Electrical Safety KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746309426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=RECONSTRUCTION+OF+RADIATION+DOSES+IN+A+CASE-CONTROL+STUDY+OF+THYROID+CANCER+FOLLOWING+THE+CHERNOBYL+ACCIDENT&rft.au=Drozdovitch%2C+V%3BKhrouch%2C+V%3BMaceika%2C+E%3BZvonova%2C+I%3BVlasov%2C+O%3BBratilova%2C+A%3BGavrilin%2C+Y%3BGoulko%2C+G%3BHoshi%2C+M%3BKesminiene%2C+A%3BShinkarev%2C+S%3BTenet%2C+V%3BCardis%2C+E%3BBouville%2C+A&rft.aulast=Drozdovitch&rft.aufirst=V&rft.date=2010-07-01&rft.volume=99&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0b013e3181c910dd LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2013-08-12 N1 - SubjectsTermNotLitGenreText - Fallout; Inhalation; Age; Accidents; Cesium; Standard deviation; Adolescence; thyroid cancer; Radioisotopes; Children; Physical training; Models; age groups; Nuclear power plants; Radioactive fallout; Thyroid; Ingestion; Adolescents; Cancer; Belarus; Ukraine, Chernobyl; Russia DO - http://dx.doi.org/10.1097/HP.0b013e3181c910dd ER - TY - JOUR T1 - Stable long-term risk of leukaemia in patients with severe congenital neutropenia maintained on G-CSF therapy AN - 746235917; 13190434 AB - SummaryIn severe congenital neutropenia (SCN), long-term therapy with granulocyte colony-stimulating factor (G-CSF) has reduced mortality from sepsis, revealing an underlying predisposition to myelodysplastic syndrome and acute myeloid leukaemia (MDS-AML). We have reported the early pattern of evolution to MDS-AML, but the long-term risk remains uncertain. We updated a prospective study of 374 SCN patients on long-term G-CSF enrolled in the Severe Chronic Neutropenia International Registry. Long-term, the annual risk of MDS-AML attained a plateau (2.3%-year after 10 years). This risk now appears similar to, rather than higher than, the risk of AML in Fanconi anaemia and dyskeratosis congenita. JF - British Journal of Haematology AU - Rosenberg, Philip S AU - Zeidler, Cornelia AU - Bolyard, Audrey A AU - Alter, Blanche P AU - Bonilla, Mary A AU - Boxer, Laurence A AU - Dror, Yigal AU - Kinsey, Sally AU - Link, Daniel C AU - Newburger, Peter E AU - Shimamura, Akiko AU - Welte, Karl AU - Dale, David C AD - 1Biostatistics Branch, National Cancer Institute, Rockville, MD, USA, rosenbep@mail.nih.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 196 EP - 199 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 150 IS - 2 SN - 0007-1048, 0007-1048 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Anemia KW - Dyskeratosis KW - Evolution KW - Granulocyte colony-stimulating factor KW - Mortality KW - Myelodysplastic syndrome KW - Neutropenia KW - Risk factors KW - Sepsis KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746235917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Haematology&rft.atitle=Stable+long-term+risk+of+leukaemia+in+patients+with+severe+congenital+neutropenia+maintained+on+G-CSF+therapy&rft.au=Rosenberg%2C+Philip+S%3BZeidler%2C+Cornelia%3BBolyard%2C+Audrey+A%3BAlter%2C+Blanche+P%3BBonilla%2C+Mary+A%3BBoxer%2C+Laurence+A%3BDror%2C+Yigal%3BKinsey%2C+Sally%3BLink%2C+Daniel+C%3BNewburger%2C+Peter+E%3BShimamura%2C+Akiko%3BWelte%2C+Karl%3BDale%2C+David+C&rft.aulast=Rosenberg&rft.aufirst=Philip&rft.date=2010-07-01&rft.volume=150&rft.issue=2&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Haematology&rft.issn=00071048&rft_id=info:doi/10.1111%2Fj.1365-2141.2010.08216.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Number of references - 10 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Myelodysplastic syndrome; Mortality; Neutropenia; Sepsis; Risk factors; Dyskeratosis; Anemia; Granulocyte colony-stimulating factor; Evolution DO - http://dx.doi.org/10.1111/j.1365-2141.2010.08216.x ER - TY - JOUR T1 - Dietary restriction mitigates cocaine-induced alterations of olfactory bulb cellular plasticity and gene expression, and behavior AN - 746158026; 13059104 AB - J. Neurochem. (2010) 114, 323-334.AbstractBecause the olfactory system plays a major role in food consumption, and because 'food addiction' and associated morbidities have reached epidemic proportions, we tested the hypothesis that dietary energy restriction can modify adverse effects of cocaine on behavior and olfactory cellular and molecular plasticity. Mice maintained on an alternate day fasting (ADF) diet exhibited increased baseline locomotion and increased cocaine-sensitized locomotion during cocaine conditioning, despite no change in cocaine conditioned place preference, compared with mice fed ad libitum. Levels of dopamine and its metabolites in the olfactory bulb (OB) were suppressed in mice on the ADF diet compared with mice on the control diet, independent of acute or chronic cocaine treatment. The expression of several enzymes involved in dopamine metabolism including tyrosine hydroxylase, monoamine oxidases A and B, and catechol-O-methyltransferase were significantly reduced in OBs of mice on the ADF diet. Both acute and chronic administration of cocaine suppressed the production of new OB cells, and this effect of cocaine was attenuated in mice on the ADF diet. Cocaine administration to mice on the control diet resulted in up-regulation of OB genes involved in mitochondrial energy metabolism, synaptic plasticity, cellular stress responses, and calcium- and cAMP-mediated signaling, whereas multiple olfactory receptor genes were down-regulated by cocaine treatment. ADF abolished many of the effects of cocaine on OB gene expression. Our findings reveal that dietary energy intake modifies the neural substrates underlying some of the behavioral and physiological responses to repeated cocaine treatment, and also suggest novel roles for the olfactory system in addiction. The data further suggest that modification of dietary energy intake could provide a novel potential approach to addiction treatments. JF - Journal of Neurochemistry AU - Xu, Xiangru AU - Mughal, Mohamed R AU - Scott Hall, F AU - Perona, Maria TG AU - Pistell, Paul J AU - Lathia, Justin D AU - Chigurupati, Srinivasulu AU - Becker, Kevin G AU - Ladenheim, Bruce AU - Niklason, Laura E AU - Uhl, George R AU - Cadet, Jean Lud AU - Mattson, Mark P AD - *Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA, mattsonm@grc.nia.nih.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 323 EP - 334 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 114 IS - 1 SN - 0022-3042, 0022-3042 KW - Chemoreception Abstracts; CSA Neurosciences Abstracts; Calcium & Calcified Tissue Abstracts; Toxicology Abstracts KW - Amine oxidase (flavin-containing) KW - Energy intake KW - Mitochondria KW - Metabolites KW - Fasting KW - Plasticity (synaptic) KW - Morbidity KW - Olfactory bulb KW - Gene expression KW - Food consumption KW - Dopamine KW - Catechol O-methyltransferase KW - Locomotion KW - Addiction KW - Cocaine KW - Olfactory system KW - Place preferences KW - Data processing KW - Epidemics KW - Energy metabolism KW - Dietary restrictions KW - Enzymes KW - Stress KW - Odorant receptors KW - Tyrosine 3-monooxygenase KW - Side effects KW - Signal transduction KW - R 18050:Chemoreception correlates of behavior KW - X 24380:Social Poisons & Drug Abuse KW - N3 11008:Neurochemistry KW - T 2020:Nutrition and Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746158026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=Dietary+restriction+mitigates+cocaine-induced+alterations+of+olfactory+bulb+cellular+plasticity+and+gene+expression%2C+and+behavior&rft.au=Xu%2C+Xiangru%3BMughal%2C+Mohamed+R%3BScott+Hall%2C+F%3BPerona%2C+Maria+TG%3BPistell%2C+Paul+J%3BLathia%2C+Justin+D%3BChigurupati%2C+Srinivasulu%3BBecker%2C+Kevin+G%3BLadenheim%2C+Bruce%3BNiklason%2C+Laura+E%3BUhl%2C+George+R%3BCadet%2C+Jean+Lud%3BMattson%2C+Mark+P&rft.aulast=Xu&rft.aufirst=Xiangru&rft.date=2010-07-01&rft.volume=114&rft.issue=1&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/10.1111%2Fj.1471-4159.2010.06782.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 76 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Amine oxidase (flavin-containing); Energy intake; Mitochondria; Metabolites; Fasting; Plasticity (synaptic); Olfactory bulb; Morbidity; Gene expression; Food consumption; Catechol O-methyltransferase; Dopamine; Locomotion; Addiction; Olfactory system; Cocaine; Place preferences; Epidemics; Data processing; Energy metabolism; Dietary restrictions; Stress; Enzymes; Odorant receptors; Tyrosine 3-monooxygenase; Side effects; Signal transduction DO - http://dx.doi.org/10.1111/j.1471-4159.2010.06782.x ER - TY - JOUR T1 - Activation of PKC isoform b sub(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain AN - 746012065; 13188269 AB - P-glycoprotein is an ATP (adenosine triphosphate)-driven drug efflux transporter that is highly expressed at the blood-brain barrier (BBB) and is a major obstacle to the pharmacotherapy of central nervous system diseases, including brain tumors, neuro-AIDS, and epilepsy. Previous studies have shown that P-glycoprotein transport activity in rat brain capillaries is rapidly reduced by the proinflammatory cytokine, tumor necrosis factor-a (TNF-a) acting through protein kinase C (PKC)-dependent signaling. In this study, we used isolated rat brain capillaries to show that the TNF-a-induced reduction of P-glycoprotein activity was prevented by a PKCb sub(I/II) inhibitor, LY333531, and mimicked by a PKCb sub(I/II) activator, 12-deoxyphorbol-13-phenylacetate-20-acetate (dPPA). Western blotting of brain capillary extracts with phospho-specific antibodies showed that dPPA activated PKCb sub(I), but not PKCb sub(II). Moreover, in intact rats, intracarotid infusion of dPPA potently increased brain accumulation of the P-glycoprotein substrate, [ super(3)H]-verapamil without compromising tight junction integrity. Thus, PKCb sub(I) activation selectively reduced P-glycoprotein activity both in vitro and in vivo. Targeting PKCb sub(I) at the BBB may prove to be an effective strategy for enhancing the delivery of small molecule therapeutics to the brain. JF - Journal of Cerebral Blood Flow and Metabolism AU - Rigor, Robert R AU - Hawkins, Brian T AU - Miller, David S AD - Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 1373 EP - 1383 PB - Nature Publishing Group VL - 30 IS - 7 SN - 0271-678X, 0271-678X KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Protein kinase C KW - Drug delivery KW - Western blotting KW - Tight junctions KW - Blood-brain barrier KW - ATP KW - Tumor necrosis factor-a KW - Capillaries KW - Inflammation KW - Brain tumors KW - Antibodies KW - P-Glycoprotein KW - Epilepsy KW - Central nervous system diseases KW - Cytokines KW - Adenosine KW - Cerebral blood flow KW - Signal transduction KW - W 30915:Pharmaceuticals & Vaccines KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746012065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cerebral+Blood+Flow+and+Metabolism&rft.atitle=Activation+of+PKC+isoform+b+sub%28I%29+at+the+blood-brain+barrier+rapidly+decreases+P-glycoprotein+activity+and+enhances+drug+delivery+to+the+brain&rft.au=Rigor%2C+Robert+R%3BHawkins%2C+Brian+T%3BMiller%2C+David+S&rft.aulast=Rigor&rft.aufirst=Robert&rft.date=2010-07-01&rft.volume=30&rft.issue=7&rft.spage=1373&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cerebral+Blood+Flow+and+Metabolism&rft.issn=0271678X&rft_id=info:doi/10.1038%2Fjcbfm.2010.21 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Protein kinase C; Western blotting; Drug delivery; Tight junctions; Blood-brain barrier; ATP; Tumor necrosis factor-a; Capillaries; Inflammation; Brain tumors; P-Glycoprotein; Antibodies; Epilepsy; Central nervous system diseases; Cytokines; Adenosine; Cerebral blood flow; Signal transduction DO - http://dx.doi.org/10.1038/jcbfm.2010.21 ER - TY - JOUR T1 - Fungal biomass is a key factor affecting polymorphonuclear leucocyte-induced hyphal damage of filamentous fungi AN - 746009633; 13059851 AB - SummaryPrevious studies have not systematically assessed the effect of fungal biomass on polymorphonuclear leucocyte (PMN)-induced hyphal damage (HD) of filamentous fungi. We hypothesised that fungal biomass is a significant factor affecting PMN-induced HD. One isolate each consisting of a volume of 2 x 104 conidia ml-1 of Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, Rhizopus oryzae, Rhizopus microsporus, Cunninghamella bertholletiae, Scedosporium prolificans and Fusarium solani were incubated for six different time periods yielding biomass values between 0.01 and 0.1 optical density (OD, 405 nm). Polymorphonuclear leucocyte were added at effector-target (E : T) ratios of 5 : 1, 10 : 1, 20 : 1, 50 : 1 and 100 : 1, and HD was assessed by XTT [2,3-bis-(2-methoxy-4-nitro-5-sulphophenyl)-2H-tetrazolium-5-carbo x anilide] metabolic assay. Hyphal damage decreased with increasing biomass following the sigmoid (Emax) model (median R2: 0.87). Hyphal damage at 0.01 OD exceeded HD at 0.1 OD (Ptwofold in 64 out of 80 comparisons. The sigmoid curves were shifted to the right with higher E : T ratios; the EC50 values (OD values showing HD halfway between maximal and minimal HD) obtained for 50 : 1 or 100 : 1 were higher than for 5 : 1 (P <0.01). Using the same E : T ratio, interspecies differences were observed; for 5 : 1, lower EC50 values were obtained for A. flavus and the zygomycete species. In conclusion, PMN-induced HD decreases with increasing biomass. This effect is both species-dependent and E : T ratio-dependent. JF - Mycoses AU - Antachopoulos, Charalampos AU - Demchok, Joanne P AU - Roilides, Emmanuel AU - Walsh, Thomas J AD - 1Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD, USA, walsht@mail.nih.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 321 EP - 328 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 53 IS - 4 SN - 0933-7407, 0933-7407 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Biomass KW - Conidia KW - Fungi KW - Leukocytes KW - Models KW - Optical density KW - Aspergillus flavus KW - Rhizopus oryzae KW - Aspergillus terreus KW - Rhizopus microsporus KW - Aspergillus fumigatus KW - Cunninghamella bertholletiae KW - Scedosporium prolificans KW - Fusarium solani KW - Zygomycetes KW - A 01360:Plant Diseases KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746009633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mycoses&rft.atitle=Fungal+biomass+is+a+key+factor+affecting+polymorphonuclear+leucocyte-induced+hyphal+damage+of+filamentous+fungi&rft.au=Antachopoulos%2C+Charalampos%3BDemchok%2C+Joanne+P%3BRoilides%2C+Emmanuel%3BWalsh%2C+Thomas+J&rft.aulast=Antachopoulos&rft.aufirst=Charalampos&rft.date=2010-07-01&rft.volume=53&rft.issue=4&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Mycoses&rft.issn=09337407&rft_id=info:doi/10.1111%2Fj.1439-0507.2009.01725.x LA - German DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 20 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Fungi; Optical density; Leukocytes; Conidia; Biomass; Models; Rhizopus microsporus; Rhizopus oryzae; Aspergillus flavus; Cunninghamella bertholletiae; Aspergillus fumigatus; Aspergillus terreus; Scedosporium prolificans; Zygomycetes; Fusarium solani DO - http://dx.doi.org/10.1111/j.1439-0507.2009.01725.x ER - TY - JOUR T1 - Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptors AN - 745712818; 13151054 AB - The reinforcing properties of ethanol are in part attributed to interactions between opioid and dopaminergic signaling pathways, but intracellular mediators of such interactions are poorly understood. Here we report that an acute ethanol challenge induces a robust phosphorylation of two key signal transduction kinases, AKT and DARPP-32, in the striatum of mice. Ethanol-induced AKT phosphorylation was blocked by the opioid receptor antagonist naltrexone but unaffected by blockade of dopamine D2 receptors via sulpiride. In contrast, DARPP-32 phosphorylation was abolished by both antagonists. These data suggest that ethanol acts via two distinct but potentially synergistic striatal signaling cascades. One of these is D2-dependent, while the other is not. These findings illustrate that pharmacology of ethanol reward is likely more complex than that for other addictive drugs. JF - Addiction Biology AU - Bjork, Karl AU - Terasmaa, Anton AU - Sun, Hui AU - Thorsell, Annika AU - Sommer, Wolfgang H AU - Heilig, Markus AD - Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD, USA and Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 299 EP - 303 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 15 IS - 3 SN - 1355-6215, 1355-6215 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Dopamine D2 receptors KW - Opioid receptors KW - DARPP-32 protein KW - Data processing KW - Pharmacology KW - Drug abuse KW - sulpiride KW - Phosphorylation KW - Neostriatum KW - Naltrexone KW - Reinforcement KW - AKT protein KW - Addiction KW - Drug addiction KW - Signal transduction KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse KW - N3 11007:Neurobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745712818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+Biology&rft.atitle=Ethanol-induced+activation+of+AKT+and+DARPP-32+in+the+mouse+striatum+mediated+by+opioid+receptors&rft.au=Bjork%2C+Karl%3BTerasmaa%2C+Anton%3BSun%2C+Hui%3BThorsell%2C+Annika%3BSommer%2C+Wolfgang+H%3BHeilig%2C+Markus&rft.aulast=Bjork&rft.aufirst=Karl&rft.date=2010-07-01&rft.volume=15&rft.issue=3&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Addiction+Biology&rft.issn=13556215&rft_id=info:doi/10.1111%2Fj.1369-1600.2010.00212.x L2 - http://www.ingentaconnect.com/content/bpl/adb/2010/00000015/00000003/art00006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - DARPP-32 protein; Opioid receptors; Dopamine D2 receptors; Data processing; Pharmacology; Drug abuse; sulpiride; Phosphorylation; Naltrexone; Neostriatum; AKT protein; Reinforcement; Addiction; Drug addiction; Ethanol; Signal transduction DO - http://dx.doi.org/10.1111/j.1369-1600.2010.00212.x ER - TY - JOUR T1 - Circulating 25-Hydroxyvitamin D and Risk of Esophageal and Gastric Cancer AN - 744707895; 13188460 AB - Upper gastrointestinal (GI) cancers of the stomach and esophagus have high incidence and mortality worldwide, but they are uncommon in Western countries. Little information exists on the association between vitamin D and risk of upper GI cancers. This study examined the association between circulating 25-hydroxyvitamin D (25(OH)D) and upper GI cancer risk in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25(OH)D were measured from 1,065 upper GI cancer cases and 1,066 age-, sex-, race-, and season-of blood draw-matched controls from 8 prospective cohort studies. In multivariate-adjusted models, circulating 25(OH)D concentration was not significantly associated with upper GI cancer risk. Subgroup analysis by race showed that among Asians, but not Caucasians, lower concentrations of 25(OH)D (<25 nmol/L) were associated with a statistically significant decreased risk of upper GI cancer (reference: 50-<75 nmol/L) (odds ratio = 0.53, 95% confidence interval: 0.31, 0.91; P trend = 0.003). Never smokers with concentrations of <25 nmol/L showed a lower risk of upper GI cancers (odds ratio = 0.55, 95% confidence interval: 0.31, 0.96). Subgroup analyses by alcohol consumption produced opposing trends. Results do not support the hypothesis that interventions aimed at increasing vitamin D status would lead to a lower risk of these highly fatal cancers. JF - American Journal of Epidemiology AU - Abnet, Christian C AU - Chen, Yu AU - Chow, Wong-Ho AU - Gao, Yu-Tang AU - Helzlsouer, Kathy J AU - Le Marchand, Loic AU - McCullough, Marjorie L AU - Shikany, James M AU - Virtamo, Jarmo AU - Weinstein, Stephanie J AU - Xiang, Yong-Bing AU - Yu, Kai AU - Zheng, Wei AU - Albanes, Demetrius AU - Arslan, Alan A AU - Campbell, David S AU - Campbell, Peter T AU - Hayes, Richard B AU - Horst, Ronald L AU - Kolonel, Laurence N AU - Nomura, Abraham MY AU - Purdue, Mark P AU - Snyder, Kirk AU - Shu, Xiao-Ou Y1 - 2010/07/01/ PY - 2010 DA - 2010 Jul 01 SP - 94 EP - 106 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 172 IS - 1 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - case-control studies KW - cohort studies KW - esophageal neoplasms KW - prospective studies KW - stomach neoplasms KW - vitamin D KW - Alcohol KW - Mortality KW - vitamins KW - intervention KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744707895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Circulating+25-Hydroxyvitamin+D+and+Risk+of+Esophageal+and+Gastric+Cancer&rft.au=Abnet%2C+Christian+C%3BChen%2C+Yu%3BChow%2C+Wong-Ho%3BGao%2C+Yu-Tang%3BHelzlsouer%2C+Kathy+J%3BLe+Marchand%2C+Loic%3BMcCullough%2C+Marjorie+L%3BShikany%2C+James+M%3BVirtamo%2C+Jarmo%3BWeinstein%2C+Stephanie+J%3BXiang%2C+Yong-Bing%3BYu%2C+Kai%3BZheng%2C+Wei%3BAlbanes%2C+Demetrius%3BArslan%2C+Alan+A%3BCampbell%2C+David+S%3BCampbell%2C+Peter+T%3BHayes%2C+Richard+B%3BHorst%2C+Ronald+L%3BKolonel%2C+Laurence+N%3BNomura%2C+Abraham+MY%3BPurdue%2C+Mark+P%3BSnyder%2C+Kirk%3BShu%2C+Xiao-Ou&rft.aulast=Abnet&rft.aufirst=Christian&rft.date=2010-07-01&rft.volume=172&rft.issue=1&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwq121 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Mortality; Alcohol; vitamins; intervention; Cancer DO - http://dx.doi.org/10.1093/aje/kwq121 ER - TY - JOUR T1 - Circulating 25-Hydroxyvitamin D and Risk of Non-Hodgkin Lymphoma AN - 744705313; 13188469 AB - Case-control studies generally suggesting an inverse association between sun exposure and non-Hodgkin lymphoma (NHL) have led to speculation that vitamin D may protect against lymphomagenesis. To examine this hypothesis, the authors conducted a pooled investigation of circulating 25-hydroxyvitamin D (25(OH)D) and subsequent NHL risk within 10 cohorts participating in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. The authors analyzed measurements from 1,353 cases and 1,778 controls using conditional logistic regression and other methods to estimate the association of 25(OH)D with NHL. No clear evidence of association between categories of 25(OH)D concentration and NHL was observed overall (P sub(trend) = 0.68) or by sex (men, P sub(trend) = 0.50; women, P sub(trend) = 0.16). Findings for other measures (continuous log(25(OH)D), categories of 25(OH)D using sex-/cohort-/season-specific quartiles as cutpoints, categories of season-adjusted residuals of predicted 25(OH)D using quartiles as cutpoints) were generally null, although some measures of increasing 25(OH)D were suggestive of an increased risk for women. Results from stratified analyses and investigations of histologic subtypes of NHL were also null. These findings do not support the hypothesis that elevated circulating 25(OH)D concentration is associated with a reduced risk of NHL. Future research investigating the biologic basis for the sunlight-NHL association should consider alternative mechanisms, such as immunologic effects. JF - American Journal of Epidemiology AU - Purdue, Mark P AU - Freedman, DMichal AU - Gapstur, Susan M AU - Helzlsouer, Kathy J AU - Laden, Francine AU - Lim, Unhee AU - Maskarinec, Gertraud AU - Rothman, Nathaniel AU - Shu, Xiao-Ou AU - Stevens, Victoria L AU - Zeleniuch-Jacquotte, Anne AU - Albanes, Demetrius AU - Bertrand, Kimberly AU - Weinstein, Stephanie J AU - Yu, Kai AU - Irish, Lonn AU - Horst, Ronald L AU - Hoffman-Bolton, Judith AU - Giovannucci, Edward L AU - Kolonel, Laurence N AU - Snyder, Kirk AU - Willett, Walter AU - Arslan, Alan A AU - Hayes, Richard B AU - Zheng, Wei AU - Xiang, Yong-Bing AU - Hartge, Patricia Y1 - 2010/07/01/ PY - 2010 DA - 2010 Jul 01 SP - 58 EP - 69 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 172 IS - 1 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Immunology Abstracts KW - calcifediol KW - calcitrol KW - case-control studies KW - cohort studies KW - 25-hydroxyvitamin D 2 KW - lymphoma, non-Hodgkin KW - prospective studies KW - vitamin D KW - non-Hodgkin's lymphoma KW - risk reduction KW - vitamins KW - Vitamin D KW - Sun KW - 25-Hydroxyvitamin D KW - Lymphoma KW - sun KW - Cancer KW - Sex KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744705313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Circulating+25-Hydroxyvitamin+D+and+Risk+of+Non-Hodgkin+Lymphoma&rft.au=Purdue%2C+Mark+P%3BFreedman%2C+DMichal%3BGapstur%2C+Susan+M%3BHelzlsouer%2C+Kathy+J%3BLaden%2C+Francine%3BLim%2C+Unhee%3BMaskarinec%2C+Gertraud%3BRothman%2C+Nathaniel%3BShu%2C+Xiao-Ou%3BStevens%2C+Victoria+L%3BZeleniuch-Jacquotte%2C+Anne%3BAlbanes%2C+Demetrius%3BBertrand%2C+Kimberly%3BWeinstein%2C+Stephanie+J%3BYu%2C+Kai%3BIrish%2C+Lonn%3BHorst%2C+Ronald+L%3BHoffman-Bolton%2C+Judith%3BGiovannucci%2C+Edward+L%3BKolonel%2C+Laurence+N%3BSnyder%2C+Kirk%3BWillett%2C+Walter%3BArslan%2C+Alan+A%3BHayes%2C+Richard+B%3BZheng%2C+Wei%3BXiang%2C+Yong-Bing%3BHartge%2C+Patricia&rft.aulast=Purdue&rft.aufirst=Mark&rft.date=2010-07-01&rft.volume=172&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwq117 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Vitamin D; Sun; 25-Hydroxyvitamin D; Lymphoma; Cancer; Sex; non-Hodgkin's lymphoma; risk reduction; vitamins; sun DO - http://dx.doi.org/10.1093/aje/kwq117 ER - TY - JOUR T1 - Meta-analysis of the acute effects of nicotine and smoking on human performance AN - 744703235; 13097123 AB - Rationale and objective: Empirical studies indicate that nicotine enhances some aspects of attention and cognition, suggesting a role in the maintenance of tobacco dependence. The purpose of this review was to update the literature since our previous review (Heishman et al. Exp Clin Psychopharmacol 2:345-395, 1994) and to determine which aspects of human performance were most sensitive to the effects of nicotine and smoking. Methods: We conducted a meta-analysis on the outcome measures of 41 double-blind, placebo-controlled laboratory studies published from 1994 to 2008. In all studies, nicotine was administered, and performance was assessed in healthy adult nonsmokers or smokers who were not tobacco-deprived or minimally deprived (,2h). Results: There were sufficient effect size data to conduct meta-analyses on nine performance domains, including motor abilities, alerting and orienting attention, and episodic and working memory. We found significant positive effects of nicotine or smoking on six domains: fine motor, alerting attention-accuracy and response time (RT), orienting attention-RT, short-term episodic memory-accuracy, and working memory-RT (effect size range=0.16 to 0.44). Conclusions: The significant effects of nicotine on motor abilities, attention, and memory likely represent true performance enhancement because they are not confounded by withdrawal relief. The beneficial cognitive effects of nicotine have implications for initiation of smoking and maintenance of tobacco dependence. JF - Psychopharmacology AU - Heishman, Stephen J AU - Kleykamp, Bethea A AU - Singleton, Edward G AD - Nicotine Psychopharmacology Section, National Institute on Drug Abuse, NIH Intramural Research Program, 251 Bayview Blvd., Baltimore, MD, 21224, USA, heishman@nih.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 453 EP - 469 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany VL - 210 IS - 4 SN - 0033-3158, 0033-3158 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Acute effects KW - Smoking KW - Memory KW - Data processing KW - Nicotine KW - Cognitive ability KW - Reviews KW - Withdrawal KW - Motor task performance KW - Tobacco KW - Short term memory KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744703235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Meta-analysis+of+the+acute+effects+of+nicotine+and+smoking+on+human+performance&rft.au=Heishman%2C+Stephen+J%3BKleykamp%2C+Bethea+A%3BSingleton%2C+Edward+G&rft.aulast=Heishman&rft.aufirst=Stephen&rft.date=2010-07-01&rft.volume=210&rft.issue=4&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-010-1848-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Acute effects; Smoking; Memory; Data processing; Cognitive ability; Nicotine; Withdrawal; Reviews; Motor task performance; Tobacco; Short term memory DO - http://dx.doi.org/10.1007/s00213-010-1848-1 ER - TY - JOUR T1 - Circulating 25-Hydroxyvitamin D and Risk of Pancreatic Cancer AN - 744699753; 13188462 AB - Results from epidemiologic studies examining pancreatic cancer risk and vitamin D intake or 25-hydroxyvitamin D (25(OH)D) concentrations (the best indicator of vitamin D derived from diet and sun) have been inconsistent. Therefore, the authors conducted a pooled nested case-control study of participants from 8 cohorts within the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP) (1974-2006) to evaluate whether prediagnostic circulating 25(OH)D concentrations were associated with the development of pancreatic cancer. In total, 952 incident pancreatic adenocarcinoma cases occurred among participants (median follow-up, 6.5 years). Controls (n = 1,333) were matched to each case by cohort, age, sex, race/ethnicity, date of blood draw, and follow-up time. Conditional logistic regression analysis was used to calculate smoking-, body mass index-, and diabetes-adjusted odds ratios and 95% confidence intervals for pancreatic cancer. Clinically relevant 25(OH)D cutpoints were compared with a referent category of 50-<75 nmol/L. No significant associations were observed for participants with lower 25(OH)D status. However, a high 25(OH)D concentration (.100 nmol/L) was associated with a statistically significant 2-fold increase in pancreatic cancer risk overall (odds ratio = 2.12, 95% confidence interval: 1.23, 3.64). Given this result, recommendations to increase vitamin D concentrations in healthy persons for the prevention of cancer should be carefully considered. JF - American Journal of Epidemiology AU - Stolzenberg-Solomon, Rachael Z AU - Jacobs, Eric J AU - Arslan, Alan A AU - Qi, Dai AU - Patel, Alpa V AU - Helzlsouer, Kathy J AU - Weinstein, Stephanie J AU - McCullough, Marjorie L AU - Purdue, Mark P AU - Shu, Xiao-Ou AU - Snyder, Kirk AU - Virtamo, Jarmo AU - Wilkins, Lynn R AU - Yu, Kai AU - Zeleniuch-Jacquotte, Anne AU - Zheng, Wei AU - Albanes, Demetrius AU - Cai, Qiuyin AU - Harvey, Chinonye AU - Hayes, Richard AU - Clipp, Sandra AU - Horst, Ronald L AU - Irish, Lonn AU - Koenig, Karen AU - Le Marchand, Loic AU - Kolonel, Laurence N Y1 - 2010/07/01/ PY - 2010 DA - 2010 Jul 01 SP - 81 EP - 93 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 172 IS - 1 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - case-control studies KW - cohort studies KW - pancreatic neoplasms KW - prospective studies KW - vitamin D KW - Diets KW - pancreatic cancer KW - Age KW - vitamins KW - body mass KW - prevention KW - Cancer KW - Ethnic groups KW - sun KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744699753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Circulating+25-Hydroxyvitamin+D+and+Risk+of+Pancreatic+Cancer&rft.au=Stolzenberg-Solomon%2C+Rachael+Z%3BJacobs%2C+Eric+J%3BArslan%2C+Alan+A%3BQi%2C+Dai%3BPatel%2C+Alpa+V%3BHelzlsouer%2C+Kathy+J%3BWeinstein%2C+Stephanie+J%3BMcCullough%2C+Marjorie+L%3BPurdue%2C+Mark+P%3BShu%2C+Xiao-Ou%3BSnyder%2C+Kirk%3BVirtamo%2C+Jarmo%3BWilkins%2C+Lynn+R%3BYu%2C+Kai%3BZeleniuch-Jacquotte%2C+Anne%3BZheng%2C+Wei%3BAlbanes%2C+Demetrius%3BCai%2C+Qiuyin%3BHarvey%2C+Chinonye%3BHayes%2C+Richard%3BClipp%2C+Sandra%3BHorst%2C+Ronald+L%3BIrish%2C+Lonn%3BKoenig%2C+Karen%3BLe+Marchand%2C+Loic%3BKolonel%2C+Laurence+N&rft.aulast=Stolzenberg-Solomon&rft.aufirst=Rachael&rft.date=2010-07-01&rft.volume=172&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwq120 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Diets; Age; pancreatic cancer; vitamins; body mass; prevention; sun; Ethnic groups; Cancer DO - http://dx.doi.org/10.1093/aje/kwq120 ER - TY - JOUR T1 - Database Comparison of the Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL) and the SRTR U.S. Transplant Registry, AN - 744699590; 13190157 AB - Data submitted by transplant programs to the Organ Procurement and Transplantation Network (OPTN) are used by the Scientific Registry of Transplant Recipients (SRTR) for policy development, performance evaluation and research. This study compared OPTN-SRTR data with data extracted from medical records by research coordinators from the nine-center A2ALL study. A2ALL data were collected independently of OPTN data submission (48 data elements among 785 liver transplant candidates-recipients; 12 data elements among 386 donors). At least 90% agreement occurred between OPTN-SRTR and A2ALL for 11-29 baseline recipient elements, 4-19 recipient transplant or follow-up elements and 6-12 donor elements. For the remaining recipient and donor elements, >10% of values were missing in OPTN-SRTR but present in A2ALL, confirming that missing data were largely avoidable. Other than variables required for allocation, the percentage missing varied widely by center. These findings support an expanded focus on data quality control by OPTN-SRTR for a broader variable set than those used for allocation. Center-specific monitoring of missing values could substantially improve the data. JF - American Journal of Transplantation AU - Gillespie, B W AU - Merion, R M AU - Ortiz-Rios, E AU - Tong, L AU - Shaked, A AU - Brown, R S AU - Ojo, A O AU - Hayashi, PH AU - Berg, CL AU - Abecassis, M M AU - Ashworth, A S AU - Friese, CE AU - Hong, J C AU - Trotter, J F AU - Everhart, JE AD - nDivision of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 1621 EP - 1633 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 10 IS - 7 SN - 1600-6135, 1600-6135 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Computer programs KW - Donors KW - Data processing KW - medical records KW - Quality control KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744699590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Transplantation&rft.atitle=Database+Comparison+of+the+Adult-to-Adult+Living+Donor+Liver+Transplantation+Cohort+Study+%28A2ALL%29+and+the+SRTR+U.S.+Transplant+Registry%2C&rft.au=Gillespie%2C+B+W%3BMerion%2C+R+M%3BOrtiz-Rios%2C+E%3BTong%2C+L%3BShaked%2C+A%3BBrown%2C+R+S%3BOjo%2C+A+O%3BHayashi%2C+PH%3BBerg%2C+CL%3BAbecassis%2C+M+M%3BAshworth%2C+A+S%3BFriese%2C+CE%3BHong%2C+J+C%3BTrotter%2C+J+F%3BEverhart%2C+JE&rft.aulast=Gillespie&rft.aufirst=B&rft.date=2010-07-01&rft.volume=10&rft.issue=7&rft.spage=1621&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Transplantation&rft.issn=16006135&rft_id=info:doi/10.1111%2Fj.1600-6143.2010.03039.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Computer programs; Databases; Donors; Data processing; medical records; Quality control DO - http://dx.doi.org/10.1111/j.1600-6143.2010.03039.x ER - TY - JOUR T1 - TLR2 activation inhibits embryonic neural progenitor cell proliferation AN - 744625201; 13145123 AB - J. Neurochem. (2010) 114, 462-474.AbstractToll-like receptors (TLRs) play essential roles in innate immunity, and increasing evidence indicates that these receptors are expressed in neurons, astrocytes, and microglia in the brain, where they mediate responses to infection, stress, and injury. To address the possibility that TLR2 heterodimer activation could affect progenitor cells in the developing brain, we analyzed the expression of TLR2 throughout mouse cortical development, and assessed the role of TLR2 heterodimer activation in neuronal progenitor cell (NPC) proliferation. TLR2 mRNA and protein was expressed in the cortex in embryonic and early postnatal stages of development, and in cultured cortical NPC. While NPC from TLR2-deficient and wild type embryos had the same proliferative capacity, TLR2 activation by the synthetic bacterial lipopeptides Pam3CSK4 and FSL1, or low molecular weight hyaluronan, an endogenous ligand for TLR2, inhibited neurosphere formation in vitro. Intracerebral in utero administration of TLR2 ligands resulted in ventricular dysgenesis characterized by increased ventricle size, reduced proliferative area around the ventricles, increased cell density, an increase in phospho-histone 3 cells, and a decrease in BrdU+ cells in the sub-ventricular zone. Our findings indicate that loss of TLR2 does not result in defects in cerebral development. However, TLR2 is expressed and functional in the developing telencephalon from early embryonic stages and infectious agent-related activation of TLR2 inhibits NPC proliferation. TLR2-mediated inhibition of NPC proliferation may therefore be a mechanism by which infection, ischemia, and inflammation adversely affect brain development. JF - Journal of Neurochemistry AU - Okun, Eitan AU - Griffioen, Kathleen J AU - Gen Son, Tae AU - Lee, Jong-Hwan AU - Roberts, Nicholas J AU - Mughal, Mohamed R AU - Hutchison, Emmette AU - Cheng, Aiwu AU - Arumugam, Thiruma V AU - Lathia, Justin D AU - van Praag, Henriette AU - Mattson, Mark P AD - *Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA, mattsonm@grc.nia.nih.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 462 EP - 474 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 114 IS - 2 SN - 0022-3042, 0022-3042 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - hyaluronan KW - Astrocytes KW - TLR2 protein KW - Cell density KW - Infection KW - Cortex KW - Embryos KW - neurospheres KW - lipopeptides KW - Neural stem cells KW - Ventricles (cerebral) KW - Brain injury KW - Brain KW - Developmental stages KW - Stress KW - Immunity KW - Ischemia KW - Microglia KW - Inflammation KW - mRNA KW - Embryogenesis KW - Neurons KW - Telencephalon KW - Cell proliferation KW - Toll-like receptors KW - N3 11003:Developmental neuroscience KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744625201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=TLR2+activation+inhibits+embryonic+neural+progenitor+cell+proliferation&rft.au=Okun%2C+Eitan%3BGriffioen%2C+Kathleen+J%3BGen+Son%2C+Tae%3BLee%2C+Jong-Hwan%3BRoberts%2C+Nicholas+J%3BMughal%2C+Mohamed+R%3BHutchison%2C+Emmette%3BCheng%2C+Aiwu%3BArumugam%2C+Thiruma+V%3BLathia%2C+Justin+D%3Bvan+Praag%2C+Henriette%3BMattson%2C+Mark+P&rft.aulast=Okun&rft.aufirst=Eitan&rft.date=2010-07-01&rft.volume=114&rft.issue=2&rft.spage=462&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/10.1111%2Fj.1471-4159.2010.06778.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Number of references - 39 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Astrocytes; hyaluronan; Cell density; TLR2 protein; Infection; Cortex; Embryos; lipopeptides; neurospheres; Neural stem cells; Ventricles (cerebral); Brain injury; Brain; Stress; Developmental stages; Ischemia; Immunity; Microglia; mRNA; Inflammation; Embryogenesis; Neurons; Telencephalon; Cell proliferation; Toll-like receptors DO - http://dx.doi.org/10.1111/j.1471-4159.2010.06778.x ER - TY - JOUR T1 - PET imaging of HER1-expressing xenografts in mice with super(86)Y-CHX-A double prime -DTPA-cetuximab AN - 744622437; 13167940 AB - Purpose: Cetuximab is a recombinant, human/mouse chimeric IgG sub(1) monoclonal antibody that binds to the epidermal growth factor receptor (EGFR/HER1). Cetuximab is approved for the treatment of patients with HER1-expressing metastatic colorectal cancer. Limitations in currently reported radiolabeled cetuximab for PET applications prompted the development of super(86)Y-CHX-A double prime -DTPA-cetuximab as an alternative for imaging HER1-expressing cancer. super(86)Y-CHX-A double prime -DTPA-cetuximab can also serve as a surrogate marker for super(90)Y therapy. Methods: Bifunctional chelate, CHX-A double prime -DTPA was conjugated to cetuximab and radiolabeled with super(86)Y. In vitro immunoreactivity was assessed in HER1-expressing A431 cells. In vivo biodistribution, PET imaging and noncompartmental pharmacokinetics were performed in mice bearing HER1-expressing human colorectal (LS-174T and HT29), prostate (PC-3 and DU145), ovarian (SKOV3) and pancreatic (SHAW) tumor xenografts. Receptor blockage was demonstrated by coinjection of either 0.1 or 0.2mg cetuximab. Results: super(86)Y-CHX-A double prime -DTPA-cetuximab was routinely prepared with a specific activity of 1.5-2GBq/mg and in vitro cell-binding in the range 65-75%. Biodistribution and PET imaging studies demonstrated high HER1-specific tumor uptake of the radiotracer and clearance from nonspecific organs. In LS-174T tumor-bearing mice injected with super(86)Y-CHX-A double prime -DTPA-cetuximab alone, super(86)Y-CHX-A double prime -DTPA-cetuximab plus 0.1mg cetuximab or 0.2mg cetuximab, the tumor uptake values at 3days were 29.3 plus or minus 4.2, 10.4 plus or minus 0.5 and 6.4 plus or minus 0.3%ID/g, respectively, demonstrating dose-dependent blockage of the target. Tumors were clearly visualized 1day after injecting 3.8-4.0MBq super(86)Y-CHX-A double prime -DTPA-cetuximab. Quantitative PET revealed the highest tumor uptake in LS-174T (29.55 plus or minus 2.67%ID/cm super(3)) and the lowest tumor uptake in PC-3 (15.92 plus or minus 1.55%ID/cm super(3)) xenografts at 3days after injection. Tumor uptake values quantified by PET were closely correlated (r super(2)=0.9, n=18) with values determined by biodistribution studies. Conclusion: This study demonstrated the feasibility of preparation of high specific activity super(86)Y-CHX-A double prime -DTPA-cetuximab and its application for quantitative noninvasive PET imaging of HER1-expressing tumors. super(86)Y-CHX-A double prime -DTPA-cetuximab offers an attractive alternative to previously labeled cetuximab for PET and further investigation for clinical translation is warranted. JF - European Journal of Nuclear Medicine and Molecular Imaging AU - Nayak, Tapan K AU - Regino, Celeste AS AU - Wong, Karen J AU - Milenic, Diane E AU - Garmestani, Kayhan AU - Baidoo, Kwamena E AU - Szajek, Lawrence P AU - Brechbiel, Martin W AD - Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 1368 EP - 1376 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 37 IS - 7 SN - 1619-7070, 1619-7070 KW - Biotechnology and Bioengineering Abstracts KW - Translation KW - Monoclonal antibodies KW - Pancreas KW - Colorectal cancer KW - Epidermal growth factor receptors KW - Tumors KW - Pharmacokinetics KW - Metastases KW - Immunoreactivity KW - Immunoglobulin G KW - Nuclear medicine KW - Xenografts KW - Chelates KW - Prostate KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744622437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.atitle=PET+imaging+of+HER1-expressing+xenografts+in+mice+with+super%2886%29Y-CHX-A+double+prime+-DTPA-cetuximab&rft.au=Nayak%2C+Tapan+K%3BRegino%2C+Celeste+AS%3BWong%2C+Karen+J%3BMilenic%2C+Diane+E%3BGarmestani%2C+Kayhan%3BBaidoo%2C+Kwamena+E%3BSzajek%2C+Lawrence+P%3BBrechbiel%2C+Martin+W&rft.aulast=Nayak&rft.aufirst=Tapan&rft.date=2010-07-01&rft.volume=37&rft.issue=7&rft.spage=1368&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.issn=16197070&rft_id=info:doi/10.1007%2Fs00259-009-1370-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Translation; Monoclonal antibodies; Pancreas; Colorectal cancer; Epidermal growth factor receptors; Tumors; Pharmacokinetics; Metastases; Immunoreactivity; Immunoglobulin G; Nuclear medicine; Xenografts; Chelates; Prostate DO - http://dx.doi.org/10.1007/s00259-009-1370-z ER - TY - JOUR T1 - A case-control study of tobacco use and other non-occupational risk factors for lymphoma subtypes defined by t(14; 18) translocations and bcl-2 expression AN - 744620255; 13100606 AB - Objective: We re-evaluated reported associations between tobacco use and other factors and non-Hodgkin lymphoma (NHL) t(14; 18)-subtypes based on fluorescence in situ hybridization (FISH) assays believed to be more sensitive than polymerase chain reaction (PCR), previously used for detecting t(14; 18). Methods: Commercial FISH assays and bcl-2 immunostaining were performed on paraffin sections to determine t(14; 18) and bcl-2 case-subtypes. Polytomous logistic regression models estimated associations between NHL case-subtypes (versus 1,245 population-based controls) and tobacco use as well as other factors. Results: Adjusting for age, state, and proxy status, t(14; 18)-negative NHL was associated with any tobacco use (vs. no tobacco use, OR=1.9, 95% CI=1.0-3.5), including current smoking (vs. no cigarette use, OR=1.9, 95% CI=1.1-3.2). Tobacco exposures were not clearly associated with t(14; 18)-positive NHL or bcl-2 case-subtypes. Hair-dye use and family history of a hemolymphatic cancer were associated with t(14; 18)-negative NHL, but the number of exposed cases was small. Conclusions: The association between t(14; 18)-negative NHL and cigarette smoking was unexpected given previous evidence of associations between smoking and follicular lymphoma (which is largely t(14; 18)-positive). Future studies characterizing additional molecular characteristics of t(14; 18)-negative NHL may help determine whether the association with smoking may have been causal versus an artifact of chance or bias. JF - Cancer Causes & Control AU - Chang, Cindy M AU - Schroeder, Jane C AU - Olshan, Andrew F AU - Dunphy, Cherie H AU - Huang, Wen-Yi AU - Baric, Ralph S AU - Conway, Kathleen AU - Cerhan, James R AU - Lynch, Charles F AU - Rothman, Nathaniel AU - Cantor, Kenneth P AU - Blair, Aaron AD - Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA, changcm@mail.nih.gov changcm@mail.nih.gov changcm@mail.nih.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 1147 EP - 1154 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 21 IS - 7 SN - 0957-5243, 0957-5243 KW - Immunology Abstracts; Toxicology Abstracts; Risk Abstracts KW - non-Hodgkin's lymphoma KW - Age KW - Cigarettes KW - artifacts KW - Models KW - Genetics KW - Risk factors KW - Cigarette smoking KW - Regression analysis KW - Tobacco KW - Polymerase chain reaction KW - Bcl-2 protein KW - Translocation KW - Lymphoma KW - Fluorescence in situ hybridization KW - Paraffin KW - Fluorescence KW - Cancer KW - Fish KW - translocation KW - lymphoma KW - X 24380:Social Poisons & Drug Abuse KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744620255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=A+case-control+study+of+tobacco+use+and+other+non-occupational+risk+factors+for+lymphoma+subtypes+defined+by+t%2814%3B+18%29+translocations+and+bcl-2+expression&rft.au=Chang%2C+Cindy+M%3BSchroeder%2C+Jane+C%3BOlshan%2C+Andrew+F%3BDunphy%2C+Cherie+H%3BHuang%2C+Wen-Yi%3BBaric%2C+Ralph+S%3BConway%2C+Kathleen%3BCerhan%2C+James+R%3BLynch%2C+Charles+F%3BRothman%2C+Nathaniel%3BCantor%2C+Kenneth+P%3BBlair%2C+Aaron&rft.aulast=Chang&rft.aufirst=Cindy&rft.date=2010-07-01&rft.volume=21&rft.issue=7&rft.spage=1147&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-010-9531-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Paraffin; Age; Cancer; Models; Risk factors; Cigarette smoking; Tobacco; Regression analysis; Polymerase chain reaction; Bcl-2 protein; Lymphoma; Translocation; Fluorescence in situ hybridization; non-Hodgkin's lymphoma; Genetics; Fluorescence; Cigarettes; Fish; translocation; lymphoma; artifacts DO - http://dx.doi.org/10.1007/s10552-010-9531-8 ER - TY - JOUR T1 - A prospective study of one-carbon metabolism biomarkers and risk of renal cell carcinoma AN - 744620249; 13100609 AB - Objective: Previous studies have found associations between one-carbon metabolism factors and risk of several cancers, but little is known regarding renal cell carcinoma (RCC). We conducted a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, a prospective study of Finnish male smokers aged 50-69 at baseline. Methods: Prediagnostic folate, vitamin B sub(6), vitamin B sub(12), cysteine, riboflavin, and homocysteine concentrations were measured in fasting serum from 224 incident RCC cases and 224 controls (matched on age and date of serum collection). Conditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for potential confounders. Results: Serum folate tended to be inversely associated with RCC, compared to the first quartile, the odds ratios (95% CI) for subsequent quartiles were 0.62 (0.35-1.08), 0.52 (0.29-0.93), and 0.67 (0.37-1.20) (P-trend=0.19). When modeled as a threshold effect, subjects in the lowest serum folate quartile (,6.64nmol/l), which corresponds to deficient folate status, had a significant increased RCC risk (OR=1.68, 95% CI 1.06-2.65) compared to those with higher serum folate. The other one-carbon metabolism biomarkers were not associated with RCC. Conclusions: This study in male smokers suggests that deficient folate status may increase risk of RCC, but confirmation is needed in other epidemiologic studies that include women and non-smokers. JF - Cancer Causes & Control AU - Gibson, Todd M AU - Weinstein, Stephanie J AU - Mayne, Susan T AU - Pfeiffer, Ruth M AU - Selhub, Jacob AU - Taylor, Philip R AU - Virtamo, Jarmo AU - Albanes, Demetrius AU - Stolzenberg-Solomon, Rachael AD - Yale School of Public Health, 60 College Street, New Haven, CT, 06520, USA, gibsontm@mail.nih.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 1061 EP - 1069 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 21 IS - 7 SN - 0957-5243, 0957-5243 KW - Toxicology Abstracts; Risk Abstracts KW - Bioindicators KW - Age KW - Vitamin B6 KW - Fasting KW - biomarkers KW - Cancer KW - vitamins KW - renal cell carcinoma KW - Vitamin B12 KW - Riboflavin KW - Cysteine KW - prevention KW - Folic acid KW - Metabolism KW - homocysteine KW - R2 23060:Medical and environmental health KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744620249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=A+prospective+study+of+one-carbon+metabolism+biomarkers+and+risk+of+renal+cell+carcinoma&rft.au=Gibson%2C+Todd+M%3BWeinstein%2C+Stephanie+J%3BMayne%2C+Susan+T%3BPfeiffer%2C+Ruth+M%3BSelhub%2C+Jacob%3BTaylor%2C+Philip+R%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius%3BStolzenberg-Solomon%2C+Rachael&rft.aulast=Gibson&rft.aufirst=Todd&rft.date=2010-07-01&rft.volume=21&rft.issue=7&rft.spage=1061&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-010-9534-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Riboflavin; Vitamin B12; renal cell carcinoma; Cysteine; Vitamin B6; Fasting; Folic acid; biomarkers; homocysteine; Metabolism; Bioindicators; Age; vitamins; prevention; Cancer DO - http://dx.doi.org/10.1007/s10552-010-9534-5 ER - TY - JOUR T1 - Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia AN - 742727107; 201019297 AB - Background The extracellular-regulated protein kinase (ERK) pathway has been implicated in processes such as neuronal plasticity and resilience in psychiatric disorders including major depressive disorder (MDD), bipolar disorder (BPD), and schizophrenia. The extent of the possible involvement of this pathway in psychiatric disorders remains unknown, as does its potential utility as a pharmacological target for the future development of novel therapeutics. Methods Western blot analyses were used to measure levels of different proteins-Rap1, B-Raf, MEK1, MEK2, ERK1/2, RSK1, CREB, NSE, and beta-actin-in the postmortem frontal cortex of individuals with schizophrenia, MDD, and BPD, as well as healthy non-psychiatric controls. Results Levels of most studied protein members of the ERK cascade were lower in individuals with psychiatric disorders than controls; differences between psychiatric groups were not statistically significant. In general, protein levels were lower in individuals with schizophrenia than in those with BPD or MDD, but protein levels varied across groups. Limitations The small number of individuals in each diagnostic group may limit our interpretation of the results. Factors such as postmortem interval, medication status at time of death, and mood state at time of death may also have influenced the findings. Discussion The results are consistent with the hypothesis that the ERK pathway is implicated in reduced neuronal plasticity associated with the course of these psychiatric illnesses. The results warrant an expanded investigation into the activity of other members of this pathway as well as other brain areas of interest. [Copyright Elsevier B.V.] JF - Journal of Affective Disorders AU - Yuan, Peixiong AU - Zhou, Rulun AU - Wang, Yun AU - Li, Xiaoxia AU - Li, Jianling AU - Chen, Guang AU - Guitart, Xavier AU - Manji, Husseini K AD - Biomarker Laboratory, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 164 EP - 169 PB - Elsevier Ltd, The Netherlands VL - 124 IS - 1-2 SN - 0165-0327, 0165-0327 KW - Bipolar disorder Major depressive disorder Schizophrenia Brain cAMP response binding element (CREB) Protein regulation KW - Depressive personality disorders KW - Schizophrenia KW - Postmortems KW - Cortex KW - Psychiatric disorders KW - Proteins KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742727107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Affective+Disorders&rft.atitle=Altered+levels+of+extracellular+signal-regulated+kinase+signaling+proteins+in+postmortem+frontal+cortex+of+individuals+with+mood+disorders+and+schizophrenia&rft.au=Yuan%2C+Peixiong%3BZhou%2C+Rulun%3BWang%2C+Yun%3BLi%2C+Xiaoxia%3BLi%2C+Jianling%3BChen%2C+Guang%3BGuitart%2C+Xavier%3BManji%2C+Husseini+K&rft.aulast=Yuan&rft.aufirst=Peixiong&rft.date=2010-07-01&rft.volume=124&rft.issue=1-2&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Journal+of+Affective+Disorders&rft.issn=01650327&rft_id=info:doi/10.1016%2Fj.jad.2009.10.017 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Proteins; Schizophrenia; Depressive personality disorders; Postmortems; Cortex; Psychiatric disorders DO - http://dx.doi.org/10.1016/j.jad.2009.10.017 ER - TY - JOUR T1 - Ribavirin improves early responses to peginterferon through improved interferon signaling. AN - 733594579; 20303352 AB - The therapeutic mechanisms of ribavirin for hepatitis C are unclear. Microarray analyses have shown that ribavirin increases induction of interferon-stimulated genes. We evaluated viral kinetics, serum cytokine expression, and viral mutagenesis during early stages of peginterferon therapy with and without ribavirin. Fifty patients with chronic hepatitis C virus (HCV) infection genotype 1 were randomly assigned to groups that were given peginterferon alpha-2a, with or without ribavirin, for 4 weeks; all patients then received an additional 44 weeks of combination therapy. First- and second-phase viral kinetics were evaluated. Serum levels of interferon-gamma-inducible protein-10 (IP10), monokine induced by interferon-gamma, and monocyte chemoattractant protein 1 were quantified as measures of the interferon-stimulated genes response. NS5A and NS5B were partially sequenced, and mutation rates were calculated. The first-phase decrease in HCV RNA was similar between groups. Patients who received ribavirin had a more rapid second-phase decrease, compared with patients who did not receive ribavirin-particularly those with an adequate first-phase decrease (0.61 vs 0.35 log10 IU/mL/week; P = .018). At 12 hours, fold induction of serum IP10 was higher in patients given the combination therapy than those given peginterferon only (7.6- vs 3.8-fold; P = .01); however, the difference was greatest in patients with an adequate first-phase decrease in HCV RNA. IP10-induction correlated with first- and second-phase kinetics and with ribavirin serum concentrations on day 3. HCV mutation rates were similar between groups. Ribavirin improves the kinetics of the early response to therapy in patients with an adequate initial response to peginterferon. Induction of interferon-stimulated cytokines correlates with viral kinetics following ribavirin therapy, suggesting that ribavirin promotes interferon signaling. Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved. JF - Gastroenterology AU - Feld, Jordan J AU - Lutchman, Glen A AU - Heller, Theo AU - Hara, Koji AU - Pfeiffer, Julie K AU - Leff, Richard D AU - Meek, Claudia AU - Rivera, Maria AU - Ko, Myung AU - Koh, Christopher AU - Rotman, Yaron AU - Ghany, Marc G AU - Haynes-Williams, Vanessa AU - Neumann, Avidan U AU - Liang, T Jake AU - Hoofnagle, Jay H AD - Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1800, USA. Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 154 EP - 62.e4 VL - 139 IS - 1 KW - Antiviral Agents KW - 0 KW - CXCL10 protein, human KW - Chemokine CXCL10 KW - Interferon-alpha KW - RNA, Viral KW - Recombinant Proteins KW - Polyethylene Glycols KW - 30IQX730WE KW - interferon alfa-2a KW - 47RRR83SK7 KW - Ribavirin KW - 49717AWG6K KW - peginterferon alfa-2a KW - Q46947FE7K KW - Abridged Index Medicus KW - Index Medicus KW - Chemokine CXCL10 -- blood KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Mutation KW - Male KW - Female KW - RNA, Viral -- blood KW - Ribavirin -- blood KW - Interferon-alpha -- therapeutic use KW - Interferon-alpha -- administration & dosage KW - Ribavirin -- pharmacology KW - Polyethylene Glycols -- therapeutic use KW - Hepatitis C, Chronic -- drug therapy KW - Antiviral Agents -- pharmacology KW - Signal Transduction -- drug effects KW - Hepatitis C, Chronic -- virology KW - Polyethylene Glycols -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733594579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Ribavirin+improves+early+responses+to+peginterferon+through+improved+interferon+signaling.&rft.au=Feld%2C+Jordan+J%3BLutchman%2C+Glen+A%3BHeller%2C+Theo%3BHara%2C+Koji%3BPfeiffer%2C+Julie+K%3BLeff%2C+Richard+D%3BMeek%2C+Claudia%3BRivera%2C+Maria%3BKo%2C+Myung%3BKoh%2C+Christopher%3BRotman%2C+Yaron%3BGhany%2C+Marc+G%3BHaynes-Williams%2C+Vanessa%3BNeumann%2C+Avidan+U%3BLiang%2C+T+Jake%3BHoofnagle%2C+Jay+H&rft.aulast=Feld&rft.aufirst=Jordan&rft.date=2010-07-01&rft.volume=139&rft.issue=1&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=1528-0012&rft_id=info:doi/10.1053%2Fj.gastro.2010.03.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-04 N1 - Date created - 2010-07-12 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Clin Cancer Res. 2007 Apr 15;13(8):2422-8 [17438101] J Virol. 2007 Apr;81(7):3391-401 [17267482] J Infect Dis. 2007 Aug 1;196(3):425-34 [17597457] Hepatology. 2007 Jul;46(1):16-21 [17596864] J Clin Microbiol. 2007 Aug;45(8):2439-45 [17581934] Hepatology. 2007 Nov;46(5):1548-63 [17929300] Proc Natl Acad Sci U S A. 2008 May 13;105(19):7034-9 [18467494] N Engl J Med. 2009 Apr 30;360(18):1839-50 [19403903] Clin Infect Dis. 2009 Aug 15;49(4):498-506 [19591593] J Biol Chem. 2001 Dec 7;276(49):46094-8 [11602568] Lancet. 2001 Oct 13;358(9289):1241-2 [11675067] J Leukoc Biol. 2002 Apr;71(4):669-76 [11927654] J Virol. 2002 Sep;76(17):8505-17 [12163570] J Virol. 2003 May;77(10):5933-47 [12719586] Hepatology. 2003 Jun;37(6):1351-8 [12774014] Virology. 2003 Jun 5;310(2):333-42 [12781720] Gastroenterology. 2004 Mar;126(3):703-14 [14988824] Hepatology. 2004 Jul;40(1):87-97 [15239090] Science. 1998 Oct 2;282(5386):103-7 [9756471] Lancet. 1998 Oct 31;352(9138):1426-32 [9807989] N Engl J Med. 1998 Nov 19;339(21):1485-92 [9819446] N Engl J Med. 1998 Nov 19;339(21):1493-9 [9819447] J Hepatol. 1999 Mar;30(3):376-82 [10190717] J Med Virol. 2005 Jan;75(1):27-34 [15543591] Nature. 2004 Dec 16;432(7019):922-4 [15602565] Nature. 2005 Aug 18;436(7053):967-72 [16107837] Gut. 2006 Mar;55(3):374-9 [16150856] J Infect Dis. 2006 Oct 1;194(7):895-903 [16960776] Gastroenterology. 2007 May;132(5):1757-66 [17484873] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1053/j.gastro.2010.03.037 ER - TY - JOUR T1 - Quantitative proteomics analysis of inborn errors of cholesterol synthesis: identification of altered metabolic pathways in DHCR7 and SC5D deficiency. AN - 733567235; 20305089 AB - Smith-Lemli-Opitz syndrome (SLOS) and lathosterolosis are malformation syndromes with cognitive deficits caused by mutations of 7-dehydrocholesterol reductase (DHCR7) and lathosterol 5-desaturase (SC5D), respectively. DHCR7 encodes the last enzyme in the Kandutsch-Russel cholesterol biosynthetic pathway, and impaired DHCR7 activity leads to a deficiency of cholesterol and an accumulation of 7-dehydrocholesterol. SC5D catalyzes the synthesis of 7-dehydrocholesterol from lathosterol. Impaired SC5D activity leads to a similar deficiency of cholesterol but an accumulation of lathosterol. Although the genetic and biochemical causes underlying both syndromes are known, the pathophysiological processes leading to the developmental defects remain unclear. To study the pathophysiological mechanisms underlying SLOS and lathosterolosis neurological symptoms, we performed quantitative proteomics analysis of SLOS and lathosterolosis mouse brain tissue and identified multiple biological pathways affected in Dhcr7(Delta3-5/Delta3-5) and Sc5d(-/-) E18.5 embryos. These include alterations in mevalonate metabolism, apoptosis, glycolysis, oxidative stress, protein biosynthesis, intracellular trafficking, and cytoskeleton. Comparison of proteome alterations in both Dhcr7(Delta3-5/Delta3-5) and Sc5d(-/-) brain tissues helps elucidate whether perturbed protein expression was due to decreased cholesterol or a toxic effect of sterol precursors. Validation of the proteomics results confirmed increased expression of isoprenoid and cholesterol synthetic enzymes. This alteration of isoprenoid synthesis may underlie the altered posttranslational modification of Rab7, a small GTPase that is functionally dependent on prenylation with geranylgeranyl, that we identified and validated in this study. These data suggested that although cholesterol synthesis is impaired in both Dhcr7(Delta3-5/Delta3-5) and Sc5d(-/-) embryonic brain tissues the synthesis of nonsterol isoprenoids may be increased and thus contribute to SLOS and lathosterolosis pathology. This proteomics study has provided insight into the pathophysiological mechanisms of SLOS and lathosterolosis, and understanding these pathophysiological changes will help guide clinical therapy for SLOS and lathosterolosis. JF - Molecular & cellular proteomics : MCP AU - Jiang, Xiao-Sheng AU - Backlund, Peter S AU - Wassif, Christopher A AU - Yergey, Alfred L AU - Porter, Forbes D AD - NICHD, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892, USA. jiangx@mail.nih.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 1461 EP - 1475 VL - 9 IS - 7 KW - rab7 protein KW - 152989-05-4 KW - lathosterol KW - 80-99-9 KW - Cholesterol KW - 97C5T2UQ7J KW - lathosterol delta-5-dehydrogenase KW - EC 1.14.21.6 KW - Oxidoreductases Acting on CH-CH Group Donors KW - EC 1.3.- KW - 7-dehydrocholesterol reductase KW - EC 1.3.1.21 KW - Caspase 3 KW - EC 3.4.22.- KW - rab GTP-Binding Proteins KW - EC 3.6.5.2 KW - rab5 GTP-Binding Proteins KW - Mevalonic Acid KW - S5UOB36OCZ KW - Index Medicus KW - Molecular Structure KW - Animals KW - rab5 GTP-Binding Proteins -- metabolism KW - Enzyme Activation KW - Mice KW - Mice, Knockout KW - Brain -- enzymology KW - Mevalonic Acid -- metabolism KW - Molecular Sequence Data KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization -- methods KW - rab GTP-Binding Proteins -- metabolism KW - Female KW - Caspase 3 -- metabolism KW - Smith-Lemli-Opitz Syndrome -- metabolism KW - Proteomics -- methods KW - Metabolic Networks and Pathways -- genetics KW - Oxidoreductases Acting on CH-CH Group Donors -- genetics KW - Cholesterol -- biosynthesis KW - Cholesterol -- metabolism KW - Smith-Lemli-Opitz Syndrome -- genetics KW - Oxidoreductases Acting on CH-CH Group Donors -- deficiency KW - Smith-Lemli-Opitz Syndrome -- pathology KW - Cholesterol -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733567235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+%26+cellular+proteomics+%3A+MCP&rft.atitle=Quantitative+proteomics+analysis+of+inborn+errors+of+cholesterol+synthesis%3A+identification+of+altered+metabolic+pathways+in+DHCR7+and+SC5D+deficiency.&rft.au=Jiang%2C+Xiao-Sheng%3BBacklund%2C+Peter+S%3BWassif%2C+Christopher+A%3BYergey%2C+Alfred+L%3BPorter%2C+Forbes+D&rft.aulast=Jiang&rft.aufirst=Xiao-Sheng&rft.date=2010-07-01&rft.volume=9&rft.issue=7&rft.spage=1461&rft.isbn=&rft.btitle=&rft.title=Molecular+%26+cellular+proteomics+%3A+MCP&rft.issn=1535-9484&rft_id=info:doi/10.1074%2Fmcp.M900548-MCP200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-04 N1 - Date created - 2010-07-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: FEBS J. 2009 Feb;276(3):622-7 [19143831] Hum Mol Genet. 2010 Apr 1;19(7):1347-57 [20067919] Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8181-6 [9653161] Am J Hum Genet. 1998 Aug;63(2):329-38 [9683613] Prog Brain Res. 2005;147:295-317 [15581714] Biochim Biophys Acta. 2005 Apr 15;1740(1):68-73 [15878743] Chem Phys Lipids. 2005 Jul;136(1):1-12 [15904906] Traffic. 2005 Dec;6(12):1070-7 [16262719] Dev Neurosci. 2005;27(6):378-96 [16280635] Electrophoresis. 2005 Dec;26(23):4540-62 [16315178] J Lipid Res. 2006 Jan;47(1):134-43 [16258167] Exp Eye Res. 2006 Mar;82(3):538-41 [16199034] Exp Eye Res. 2006 Mar;82(3):496-504 [16360150] Mol Genet Metab. 2006 Mar;87(3):272-7 [16343970] J Cell Sci. 2006 May 1;119(Pt 9):1876-85 [16636072] J Exp Med. 2006 May 15;203(5):1161-71 [16618793] J Neural Transm Suppl. 1999;57:87-97 [10666670] Biophys Chem. 2000 May 15;84(3):269-79 [10852314] J Lipid Res. 2000 Sep;41(9):1437-47 [10974051] Free Radic Biol Med. 2000 Aug;29(3-4):285-94 [11035257] Biophys Chem. 2001 Feb 15;89(2-3):163-72 [11254209] Hum Mol Genet. 2001 Mar 15;10(6):555-64 [11230174] Biochem Biophys Res Commun. 2001 Aug 10;286(1):176-83 [11485325] Neurochem Res. 2001 Apr;26(4):353-61 [11495345] Mol Genet Metab. 2001 Sep-Oct;74(1-2):105-19 [11592808] Mol Neurobiol. 2001 Aug-Dec;24(1-3):131-44 [11831549] Biochim Biophys Acta. 2002 Mar 16;1586(2):155-68 [11959457] J Clin Invest. 2002 May;109(9):1125-31 [11994399] Biochim Biophys Acta. 2002 Apr 24;1586(3):344-52 [11997085] Mol Genet Metab. 2002 Apr;75(4):325-34 [12051964] Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8277-82 [12034881] J Neurosci Res. 2002 Aug 15;69(4):550-8 [12210848] Am J Hum Genet. 2002 Oct;71(4):952-8 [12189593] J Lipid Res. 2002 Oct;43(10):1661-9 [12364550] Anal Chem. 2002 Oct 15;74(20):5383-92 [12403597] Nat Genet. 2003 Apr;33(4):508-13 [12652302] Pediatr Res. 2003 Apr;53(4):654-62 [12612190] Nature. 2003 Apr 17;422(6933):741-5 [12700767] Expert Opin Biol Ther. 2003 Feb;3(1):127-39 [12718737] Hum Mol Genet. 2003 Jul 1;12(13):1631-41 [12812989] Rapid Commun Mass Spectrom. 2003;17(20):2310-6 [14558131] Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12027-32 [14512514] Curr Opin Pediatr. 2003 Dec;15(6):607-13 [14631207] Anal Chem. 2003 Sep 1;75(17):4646-58 [14632076] J Immunol. 2004 Feb 15;172(4):2316-23 [14764700] J Lipid Res. 2004 Feb;45(2):347-55 [14594996] Biochem Cell Biol. 2004 Feb;82(1):201-11 [15052338] J Mol Med (Berl). 2004 Aug;82(8):510-29 [15175861] Proc Natl Acad Sci U S A. 1969 Aug;63(4):1365-9 [5260939] Brain Res. 1971 Oct 29;33(2):439-50 [5167448] Am J Med Genet. 1990 Mar;35(3):397-405 [2309789] J Biol Chem. 1992 Sep 25;267(27):19730-5 [1527094] Biochim Biophys Acta. 1994 Jun 2;1212(3):259-77 [8199197] Mech Ageing Dev. 1994 Oct 20;76(2-3):165-76 [7885063] Anal Biochem. 1995 Jan 1;224(1):451-5 [7710111] Nature. 1995 Jul 6;376(6535):37-43 [7596430] Pediatr Res. 1995 May;37(5):671-4 [7603789] Gerontology. 1995;41 Suppl 2:249-57 [8821336] J Cell Biol. 1997 Mar 24;136(6):1227-37 [9087439] Am J Psychiatry. 1997 Aug;154(8):1063-9 [9247390] Am J Hum Genet. 1998 Jul;63(1):55-62 [9634533] Development. 2006 Jun;133(12):2395-405 [16687448] J Biol Chem. 2006 Aug 4;281(31):21903-13 [16735517] J Cell Physiol. 2006 Dec;209(3):836-44 [16972256] FEBS Lett. 2006 Oct 9;580(23):5442-9 [16876788] J Lipid Res. 2006 Dec;47(12):2789-98 [16983147] PLoS Biol. 2006 Jul;4(8):e232 [16895439] FEBS Lett. 2007 May 22;581(11):2125-30 [17316615] Biochem Biophys Res Commun. 2007 Jun 29;358(2):495-9 [17493586] Clin Biochem. 2007 Jun;40(9-10):575-84 [17467679] Nat Rev Drug Discov. 2007 Jul;6(7):541-55 [17585331] Am J Med Genet A. 2007 Oct 15;143A(20):2371-81 [17853487] Front Biosci. 2008;13:657-76 [17981578] Annu Rev Genet. 2007;41:401-27 [17666007] Brain. 2008 Jan;131(Pt 1):90-108 [18000012] Chem Res Toxicol. 2008 Jan;21(1):172-88 [18052107] Eur J Hum Genet. 2008 May;16(5):535-41 [18285838] Biochim Biophys Acta. 2008 Jun;1778(6):1508-16 [18381059] J Cell Biol. 2008 Nov 3;183(3):513-26 [18981234] J Cell Mol Med. 2008 Dec;12(6A):2263-80 [18624755] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/mcp.M900548-MCP200 ER - TY - JOUR T1 - Sequential loss of cell cycle checkpoint control contributes to malignant transformation of murine embryonic fibroblasts induced by 20-methylcholanthrene. AN - 733558364; 20232303 AB - Definitive information about the number and nature of discrete steps of tumorigenesis is enigmatic. To understand the multistep nature of carcinogenesis, an in vitro model of 20-Methylcholanthrene-treated primary fibroblast cells CNCI-PM-20, from 20-day old Swiss mouse embryo was used. Visible neoplastic changes with distinct morphological variations along with specific chromosomal aberrations like Robertsonian metacentrics, double and single-minute chromosomes and aneuploidy were observed from Passage-20 onwards. The cell cycle profile showed gradual increase in G(2)/M population till P-32, followed by evasion of block from P-36 onwards. Gradual increase in expression of C-myc, CyclinD1 and a decrease in expression of P21 was observed from P-20 onwards. CDC25A expression was significantly increased at P-27 and remained more or less constant in subsequent passages. Additionally, an increased P16 and P53 expression were seen at P-20 followed by their significant down-regulation at P-32. An increased level of phosphorylated retinoblastoma (ppRb) was observed from P-27, probably responsible for a compromised G(1)/S checkpoint. The inactivation of p21 and p16 might be due to their promoter hyper-methylation as suggested through de-methylation experiment by 5-aza-deoxycytidine at P-42. G(2)/M checkpoint abrogation was marked by gradual increase in expression of CyclinB1 and Cdc20, and a significant increase of Mad2 at P-20. Interestingly, increased expression of phospho-ATM, ATR and phospho-Chk1 were also seen at P-20 followed by their down-regulation at subsequent passages, indicating a perturbation of DNA damage response pathway at early passages. Our findings therefore dramatize the multiple genetic events that can cooperate to promote tumorigenesis. (c) 2010 Wiley-Liss, Inc. JF - Journal of cellular physiology AU - Mukherjee, Sudeshna AU - Manna, Sugata AU - Pal, Debolina AU - Mukherjee, Pratima AU - Panda, Chinmay K AD - Department of Oncogene Regulation, Chittaranjan National Cancer Institute, Kolkata, India. Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 49 EP - 58 VL - 224 IS - 1 KW - Antimetabolites KW - 0 KW - Carcinogens KW - Cell Cycle Proteins KW - Methylcholanthrene KW - 56-49-5 KW - decitabine KW - 776B62CQ27 KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - Animals KW - Azacitidine -- pharmacology KW - Aneuploidy KW - DNA Damage KW - Azacitidine -- analogs & derivatives KW - Gestational Age KW - Mice KW - Embryo, Mammalian -- metabolism KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Phenotype KW - Genotype KW - Antimetabolites -- pharmacology KW - Chromosome Aberrations -- chemically induced KW - Phosphorylation KW - DNA Methylation -- drug effects KW - Epigenesis, Genetic -- drug effects KW - Embryo, Mammalian -- drug effects KW - Signal Transduction KW - Cell Line KW - Cell Proliferation -- drug effects KW - Fibroblasts -- drug effects KW - Cell Transformation, Neoplastic -- pathology KW - Cell Transformation, Neoplastic -- metabolism KW - Carcinogens -- toxicity KW - Fibroblasts -- metabolism KW - Cell Cycle Proteins -- metabolism KW - Fibroblasts -- pathology KW - Cell Cycle Proteins -- genetics KW - Methylcholanthrene -- toxicity KW - Cell Transformation, Neoplastic -- chemically induced KW - Cell Cycle -- genetics KW - Cell Cycle -- drug effects KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733558364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+physiology&rft.atitle=Sequential+loss+of+cell+cycle+checkpoint+control+contributes+to+malignant+transformation+of+murine+embryonic+fibroblasts+induced+by+20-methylcholanthrene.&rft.au=Mukherjee%2C+Sudeshna%3BManna%2C+Sugata%3BPal%2C+Debolina%3BMukherjee%2C+Pratima%3BPanda%2C+Chinmay+K&rft.aulast=Mukherjee&rft.aufirst=Sudeshna&rft.date=2010-07-01&rft.volume=224&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+physiology&rft.issn=1097-4652&rft_id=info:doi/10.1002%2Fjcp.22089 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-24 N1 - Date created - 2010-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jcp.22089 ER - TY - JOUR T1 - Inhibition of mTORC1 signaling reduces tumor growth but does not prevent cancer progression in a mouse model of thyroid cancer. AN - 733503306; 20299527 AB - Selective drugs targeting dysregulated oncogenic pathways are promising cancer therapies. Because the mammalian target of rapamycin complex 1 (mTORC1) pathway is hyperactivated in human follicular thyroid cancer (FTC), we hypothesized that its inhibition could block cancer development and progression. We, therefore, analyzed the effect of a treatment with a specific mTORC1 inhibitor (RAD001) in a faithful mouse model of FTC with constitutive mTORC1 activation (TRbeta(PV/PV)Pten(+/-) mice). The treatment did not prevent capsular and vascular invasion of the thyroid and the occurrence of lung metastasis. However, it substantially decelerated thyroid tumor growth, thereby prolonging TRbeta(PV/PV)Pten(+/-) mouse life span. RAD001 efficiently inhibited mTORC1 activity, as shown by the reduced phosphorylation of its downstream targets involved in the activity of the translation machinery, such as ribosomal S6 kinase (p70(S6K)), eukaryotic translation initiation factor 4E binding protein (4E-BP1) and the eukaryotic translation initiation factors eIF-4B and eIF-4G. Whereas mTORC1 signaling inhibition did not alter cell apoptosis, it induced a significant decrease in cell proliferation that was associated with the reduced abundance and altered activity of key regulators of cell cycle progression. Altogether, our data indicate that mTORC1 signaling plays a major role in the integration of the mitogenic signal in FTC. Therefore, our preclinical study with a relevant mouse model of FTC demonstrates for the first time that RAD001 efficaciously stabilizes cancer growth although it does not prevent its fatal outcome. In conclusion, our work underscores that in the treatment of FTC patients, RAD001 can only be used in combination with drugs and therapies inducing tumor shrinkage and blocking metastasis. JF - Carcinogenesis AU - Guigon, Celine J AU - Fozzatti, Laura AU - Lu, Changxue AU - Willingham, Mark C AU - Cheng, Sheue-Yann AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4264, USA. Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 1284 EP - 1291 VL - 31 IS - 7 KW - Multiprotein Complexes KW - 0 KW - Proteins KW - Thyroid Hormone Receptors beta KW - Transcription Factors KW - mechanistic target of rapamycin complex 1 KW - Everolimus KW - 9HW64Q8G6G KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - TOR Serine-Threonine Kinases KW - EC 2.7.1.1 KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Ribosomal Protein S6 Kinases KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - PTEN Phosphohydrolase KW - EC 3.1.3.67 KW - Pten protein, mouse KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Animals KW - Phosphatidylinositol 3-Kinases -- physiology KW - Disease Progression KW - Disease Models, Animal KW - Mice KW - Ribosomal Protein S6 Kinases -- physiology KW - Sirolimus -- pharmacology KW - Apoptosis -- drug effects KW - PTEN Phosphohydrolase -- physiology KW - Extracellular Signal-Regulated MAP Kinases -- physiology KW - Thyroid Hormone Receptors beta -- genetics KW - Proto-Oncogene Proteins c-akt -- physiology KW - Cell Cycle KW - Sirolimus -- analogs & derivatives KW - Transcription Factors -- physiology KW - Transcription Factors -- antagonists & inhibitors KW - Signal Transduction -- drug effects KW - Thyroid Neoplasms -- drug therapy KW - Thyroid Neoplasms -- pathology KW - Thyroid Neoplasms -- prevention & control KW - Thyroid Neoplasms -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733503306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Inhibition+of+mTORC1+signaling+reduces+tumor+growth+but+does+not+prevent+cancer+progression+in+a+mouse+model+of+thyroid+cancer.&rft.au=Guigon%2C+Celine+J%3BFozzatti%2C+Laura%3BLu%2C+Changxue%3BWillingham%2C+Mark+C%3BCheng%2C+Sheue-Yann&rft.aulast=Guigon&rft.aufirst=Celine&rft.date=2010-07-01&rft.volume=31&rft.issue=7&rft.spage=1284&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgq059 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-12 N1 - Date created - 2010-06-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer. 1998 Sep 1;83(5):1012-21 [9731906] Mol Cell Biol. 1998 Feb;18(2):753-61 [9447971] Cancer. 1998 Dec 15;83(12):2638-48 [9874472] Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1563-8 [9990064] Genes Dev. 1999 Jun 1;13(11):1422-37 [10364159] Endocrinology. 2005 Oct;146(10):4456-63 [16002527] Cell Cycle. 2006 Jan;5(1):61-70 [16294008] Cancer Res. 2006 Feb 1;66(3):1500-8 [16452206] Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1780-5 [16446424] Oncogene. 2006 May 4;25(19):2736-47 [16314832] Semin Oncol. 2006 Apr;33(2 Suppl 7):S18-25 [16730273] Nat Rev Cancer. 2006 Sep;6(9):729-34 [16915295] J Clin Invest. 2006 Nov;116(11):2972-84 [17039256] Cancer Res. 2007 Feb 1;67(3):959-66 [17283127] Oncogene. 2007 Feb 22;26(8):1188-200 [16936779] J Clin Invest. 2007 Mar;117(3):730-8 [17290308] Blood. 2007 Apr 15;109(8):3509-12 [17179228] Nat Med. 2007 Jun;13(6):748-53 [17496901] Carcinogenesis. 2007 Dec;28(12):2451-8 [17660507] Cancer Res. 2008 Jan 15;68(2):444-9 [18199538] Am Surg. 2008 May;74(5):389-99 [18481494] Clin Cancer Res. 2008 Jun 15;14(12):3993-4001 [18559622] Mol Cell Biol. 2008 Jul;28(14):4598-608 [18474620] J Clin Invest. 2008 Sep;118(9):3065-74 [18725988] Curr Opin Pharmacol. 2008 Aug;8(4):393-412 [18721898] Oncogene. 2009 Jan 29;28(4):509-17 [18997818] Cancer Res. 2009 Mar 1;69(5):1821-7 [19244117] IUBMB Life. 2009 May;61(5):528-36 [19391168] J Clin Endocrinol Metab. 2009 May;94(5):1493-9 [19258410] Cancer Res. 2009 Jun 1;69(11):4577-81 [19458076] Horm Metab Res. 2009 Oct;41(10):752-6 [19513966] Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14 [11069286] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3583-8 [11248121] Cancer Res. 2001 Aug 15;61(16):6105-11 [11507060] Rev Endocr Metab Disord. 2000 Jan;1(1-2):97-108 [11704998] Thyroid. 2002 Nov;12(11):963-9 [12490073] Endocr J. 2003 Feb;50(1):77-83 [12733712] Cancer Res. 2003 Sep 1;63(17):5274-80 [14500358] Cancer Res. 2004 Jan 1;64(1):252-61 [14729632] Nat Rev Cancer. 2004 May;4(5):335-48 [15122205] J Clin Endocrinol Metab. 1991 Nov;73(5):990-4 [1682340] Cancer Treat Res. 1997;90:149-69 [9367082] Presse Med. 1998 Oct 3;27(29):1479-81 [9798467] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgq059 ER - TY - JOUR T1 - Eugenol restricts DMBA croton oil induced skin carcinogenesis in mice: downregulation of c-Myc and H-ras, and activation of p53 dependent apoptotic pathway. AN - 733404930; 20537511 AB - Eugenol is the active component of essential oil isolated from clove (Syzigium aromaticum). Eugenol has antimutagenic, antigenotoxic, anti-inflammatory properties. The anticarcinogenic effect of eugenol was evident in different types of cell lines. However, its anticarcinogenic effect in in vivo has not yet been fully explored. The aim of this study is to evaluate the chemopreventive potential of eugenol in an experimental skin carcinogenesis mice model system. Skin tumor was induced by topical application of DMBA croton oil in Swiss mice. To assess the chemopreventive potential of eugenol, it was orally administered 15 days prior carcinogen treatment. The development of skin carcinogenesis was confirmed by histopathological analysis. Cellular proliferation and apoptosis in the skin tumor were analyzed by in situ cellular proliferation and in situ cell death assay. Expression of some proliferation and apoptosis associated genes was analyzed by RT-PCR and protein expression was analyzed by Western blot. Reduction in incidence and sizes of skin tumors along with overall increase in survival of mice were seen due to eugenol treatment. Restriction of skin carcinogenesis at the dysplastic stage along with reduced rate of cellular proliferation and increase in apoptosis were evident in eugenol treated skin tumors. Eugenol treatment led to the downregulation of c-Myc, H-ras and Bcl2 expression along with upregulation of P53, Bax and active Caspase-3 expression in the skin lesions. Restriction of skin carcinogenesis at dysplastic stage by eugenol was due to attenuation of c-Myc, H-ras and modification of some p53 associated gene expression. Copyright (c) 2010 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved. JF - Journal of dermatological science AU - Pal, Debolina AU - Banerjee, Sarmistha AU - Mukherjee, Sudeshna AU - Roy, Anup AU - Panda, Chinmay K AU - Das, Sukta AD - Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700026, India. Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 31 EP - 39 VL - 59 IS - 1 KW - Anticarcinogenic Agents KW - 0 KW - Proto-Oncogene Proteins KW - Proto-Oncogene Proteins c-bcl-2 KW - bcl-2-Associated X Protein KW - Bcl2 protein, mouse KW - 114100-40-2 KW - Eugenol KW - 3T8H1794QW KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Croton Oil KW - 8001-28-3 KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Animals KW - Genes, ras -- drug effects KW - Genes, p53 -- drug effects KW - Proto-Oncogene Proteins -- analysis KW - Up-Regulation -- drug effects KW - Apoptosis -- drug effects KW - Mice KW - Genes, myc -- drug effects KW - Caspase 3 -- analysis KW - Down-Regulation -- drug effects KW - Female KW - bcl-2-Associated X Protein -- analysis KW - Croton Oil -- toxicity KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - Skin Neoplasms -- chemically induced KW - Eugenol -- pharmacology KW - Anticarcinogenic Agents -- pharmacology KW - Cell Transformation, Neoplastic -- chemically induced KW - Skin Neoplasms -- pathology KW - Cell Transformation, Neoplastic -- drug effects KW - Skin Neoplasms -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733404930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+dermatological+science&rft.atitle=Eugenol+restricts+DMBA+croton+oil+induced+skin+carcinogenesis+in+mice%3A+downregulation+of+c-Myc+and+H-ras%2C+and+activation+of+p53+dependent+apoptotic+pathway.&rft.au=Pal%2C+Debolina%3BBanerjee%2C+Sarmistha%3BMukherjee%2C+Sudeshna%3BRoy%2C+Anup%3BPanda%2C+Chinmay+K%3BDas%2C+Sukta&rft.aulast=Pal&rft.aufirst=Debolina&rft.date=2010-07-01&rft.volume=59&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Journal+of+dermatological+science&rft.issn=1873-569X&rft_id=info:doi/10.1016%2Fj.jdermsci.2010.04.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-01 N1 - Date created - 2010-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jdermsci.2010.04.013 ER - TY - JOUR T1 - Controlling somatic hypermutation in immunoglobulin variable and switch regions. AN - 733398607; 20082153 AB - Activation-induced deaminase (AID) is a B-cell-specific enzyme required for initiating the mechanisms of affinity maturation and isotype switching of antibodies. AID functions by deaminating cytosine to uracil in DNA, which initiates a cascade of events resulting in mutations and strand breaks in the immunoglobulin loci. There is an intricate interplay between faithful DNA repair and mutagenic DNA repair during somatic hypermutation, in that some proteins from accurate repair pathways are also involved in mutagenesis. One factor that shifts the balance from faithful to mutagenic repair is the genomic sequence of the switch regions. Indeed, the sequence of the switch mu region is designed to maximize AID access to increase the abundance of clustered dU bases. The frequency and proximity of these dU nucleotides then in turn inhibit faithful repair and promote strand breaks. JF - Immunologic research AU - Maul, Robert W AU - Gearhart, Patricia J AD - Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 113 EP - 122 VL - 47 IS - 1-3 KW - Immunoglobulin Variable Region KW - 0 KW - Immunoglobulins KW - Uracil-DNA Glycosidase KW - EC 3.2.2.- KW - AICDA (activation-induced cytidine deaminase) KW - EC 3.5.4.- KW - Cytidine Deaminase KW - EC 3.5.4.5 KW - Index Medicus KW - Cytidine Deaminase -- metabolism KW - Animals KW - Immunoglobulins -- genetics KW - Base Sequence KW - DNA Repair KW - Humans KW - Uracil-DNA Glycosidase -- genetics KW - Uracil-DNA Glycosidase -- metabolism KW - Cytidine Deaminase -- genetics KW - Mice KW - Immunoglobulin Variable Region -- genetics KW - Somatic Hypermutation, Immunoglobulin KW - Immunoglobulin Class Switching KW - Mutation KW - Immunoglobulin Switch Region -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733398607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunologic+research&rft.atitle=Controlling+somatic+hypermutation+in+immunoglobulin+variable+and+switch+regions.&rft.au=Maul%2C+Robert+W%3BGearhart%2C+Patricia+J&rft.aulast=Maul&rft.aufirst=Robert&rft.date=2010-07-01&rft.volume=47&rft.issue=1-3&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Immunologic+research&rft.issn=1559-0755&rft_id=info:doi/10.1007%2Fs12026-009-8142-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-21 N1 - Date created - 2010-06-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2002 Feb 15;295(5558):1301-6 [11847344] Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14553-8 [11717399] Nature. 2002 Jul 4;418(6893):99-103 [12097915] Nature. 2002 Sep 5;419(6902):43-8 [12214226] Cell. 2004 Aug 20;118(4):431-8 [15315756] Nat Immunol. 2004 Nov;5(11):1117-23 [15489857] J Exp Med. 1990 Dec 1;172(6):1717-27 [2258702] Immunity. 1996 Jan;4(1):57-65 [8574852] J Exp Med. 1998 Jun 1;187(11):1745-51 [9607916] Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6953-8 [9618520] Immunity. 1998 Jul;9(1):127-34 [9697842] Immunity. 1998 Jul;9(1):135-41 [9697843] J Immunol. 1999 Mar 15;162(6):3121-4 [10092760] J Exp Med. 1999 Jul 5;190(1):21-30 [10429667] Nat Immunol. 2004 Dec;5(12):1275-81 [15531884] J Exp Med. 2005 Feb 21;201(4):637-45 [15710654] J Exp Med. 2005 Apr 18;201(8):1191-6 [15824086] Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8656-61 [15939880] DNA Repair (Amst). 2006 Mar 7;5(3):392-8 [16443401] J Exp Med. 2006 Feb 20;203(2):319-23 [16476771] Mol Immunol. 2006 Apr;43(10):1587-94 [16263170] J Exp Med. 2006 Sep 4;203(9):2085-94 [16894013] J Exp Med. 2007 Jan 22;204(1):17-23 [17190840] J Biol Chem. 2007 Jun 15;282(24):17387-94 [17449470] Mol Cell Biol. 2007 Aug;27(16):5921-32 [17562862] J Exp Med. 2007 Nov 26;204(12):3017-26 [18025127] J Immunol. 2008 Feb 15;180(4):2019-23 [18250404] DNA Repair (Amst). 2008 Sep 1;7(9):1603-8 [18485835] Mol Cell. 2008 Aug 22;31(4):474-84 [18722174] J Exp Med. 2008 Sep 1;205(9):1949-57 [18678733] PLoS Genet. 2009 Jan;5(1):e1000332 [19132090] J Exp Med. 2009 Feb 16;206(2):477-90 [19204108] J Exp Med. 2009 Jun 8;206(6):1237-44 [19433618] Mol Immunol. 2009 Oct;46(16):3283-91 [19699530] Curr Biol. 2002 Oct 15;12(20):1748-55 [12401169] Eur J Immunol. 2002 Nov;32(11):3152-60 [12555660] Nat Immunol. 2003 May;4(5):442-51 [12679812] J Exp Med. 2003 May 5;197(9):1173-81 [12732658] J Exp Med. 2003 Jun 16;197(12):1767-78 [12810694] Nature. 2003 Jul 3;424(6944):103-7 [12819663] J Exp Med. 2003 Aug 18;198(4):635-43 [12925679] Oncogene. 2003 Aug 21;22(35):5381-6 [12934097] Nat Immunol. 2003 Oct;4(10):1023-8 [12958596] Mol Cell. 2003 Aug;12(2):501-8 [14536088] Science. 2003 Dec 19;302(5653):2137-40 [14684824] J Exp Med. 2004 Jan 19;199(2):265-70 [14734526] Nat Immunol. 2004 Feb;5(2):224-9 [14716311] J Exp Med. 2004 Apr 5;199(7):917-24 [15051760] J Exp Med. 2004 Jul 5;200(1):47-59 [15238604] J Exp Med. 2004 Jul 5;200(1):61-8 [15238605] J Exp Med. 2000 Feb 7;191(3):579-84 [10662804] Cell. 2000 Sep 1;102(5):553-63 [11007474] Cell. 2000 Sep 1;102(5):565-75 [11007475] Nat Immunol. 2001 Jun;2(6):537-41 [11376341] J Immunol. 2002 Apr 15;168(8):3702-6 [11937519] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s12026-009-8142-5 ER - TY - JOUR T1 - The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver. AN - 733345474; 20371638 AB - Mouse CYP2C55 has been characterized as an enzyme that catalyzes synthesis of 19-hydroxyeicosatetraenoic acid (19-HETE), an arachidonic acid metabolite known to have important physiological functions such as regulation of renal vascular tone and ion transport. We have now found that CYP2C55 is induced by phenobarbital (PB) and pregnenolone 16alpha-carbonitrile (PCN) in both mouse kidney and liver. The nuclear xenobiotic receptors constitutive active/androstane receptor (CAR) and pregnane X receptor (PXR) regulate these drug inductions: CYP2C55 mRNA was increased 25-fold in PB-treated Car(+/+) but not in Car(-/-) mice and was induced in Pxr(+/+) but not Pxr(-/-) mice after PCN treatment. Cell-based promoter analysis and gel shift assays identified the DNA sequence (-1679)TGAACCCAGTTGAACT(-1664) as a DR4 motif that regulates CAR- and PXR-mediated transcription of the Cyp2c55 gene. Chronic PB treatment increased hepatic microsomal CYP2C55 protein and serum 19-HETE levels. These findings indicate that CAR and PXR may play a role in regulation of drug-induced synthesis of 19-HETE in the mouse. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Konno, Yoshihiro AU - Kamino, Hiroki AU - Moore, Rick AU - Lih, Fred AU - Tomer, Kenneth B AU - Zeldin, Darryl C AU - Goldstein, Joyce A AU - Negishi, Masahiko AD - Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 1177 EP - 1182 VL - 38 IS - 7 KW - Hydroxyeicosatetraenoic Acids KW - 0 KW - Receptors, Cytoplasmic and Nuclear KW - Receptors, Steroid KW - Transcription Factors KW - constitutive androstane receptor KW - pregnane X receptor KW - Pregnenolone Carbonitrile KW - 1434-54-4 KW - 19-hydroxy-5,8,11,14-eicosatetraenoic acid KW - 79551-85-2 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Cyp2c55 protein, mouse KW - EC 1.14.14.1 KW - Cytochrome P450 Family 2 KW - Phenobarbital KW - YQE403BP4D KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Phenobarbital -- pharmacology KW - Kidney -- metabolism KW - Base Sequence KW - Random Allocation KW - Microsomes, Liver -- metabolism KW - Hydroxyeicosatetraenoic Acids -- blood KW - Mice KW - Sequence Analysis, DNA KW - Transcription Factors -- genetics KW - Pregnenolone Carbonitrile -- pharmacology KW - Mice, Knockout KW - Receptors, Cytoplasmic and Nuclear -- agonists KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Cytochrome P-450 Enzyme System -- genetics KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Receptors, Steroid -- metabolism KW - Transcriptional Activation -- drug effects KW - Cytochrome P-450 Enzyme System -- biosynthesis KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - Receptors, Steroid -- genetics KW - Receptors, Steroid -- agonists UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733345474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=The+nuclear+receptors+constitutive+active%2Fandrostane+receptor+and+pregnane+x+receptor+activate+the+Cyp2c55+gene+in+mouse+liver.&rft.au=Konno%2C+Yoshihiro%3BKamino%2C+Hiroki%3BMoore%2C+Rick%3BLih%2C+Fred%3BTomer%2C+Kenneth+B%3BZeldin%2C+Darryl+C%3BGoldstein%2C+Joyce+A%3BNegishi%2C+Masahiko&rft.aulast=Konno&rft.aufirst=Yoshihiro&rft.date=2010-07-01&rft.volume=38&rft.issue=7&rft.spage=1177&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=1521-009X&rft_id=info:doi/10.1124%2Fdmd.110.032334 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-12 N1 - Date created - 2010-06-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biochem Mol Toxicol. 2007;21(4):176-81 [17936931] Mol Pharmacol. 2008 Mar;73(3):1029-36 [18156313] J Lipid Res. 2000 Feb;41(2):163-81 [10681399] Am J Physiol Renal Physiol. 2000 Jun;278(6):F949-53 [10836982] Biochem J. 2000 Apr 15;347(Pt 2):321-37 [10749660] Annu Rev Pharmacol Toxicol. 2001;41:123-43 [11264453] J Biol Chem. 2001 Jul 6;276(27):25467-79 [11328810] J Biol Chem. 2001 Sep 28;276(39):36059-62 [11451964] Drug Metab Dispos. 2001 Nov;29(11):1467-72 [11602523] Mol Pharmacol. 2002 Jan;61(1):1-6 [11752199] J Biol Chem. 2002 Jan 4;277(1):209-17 [11679585] Mol Pharmacol. 2002 Sep;62(3):737-46 [12181452] J Lipid Res. 2002 Sep;43(9):1563-78 [12235189] Mol Pharmacol. 2003 Aug;64(2):316-24 [12869636] J Pharmacol Exp Ther. 2004 Feb;308(2):495-501 [14600250] Mol Pharmacol. 2004 May;65(5):1148-58 [15102943] Pharmacogenetics. 2004 Jan;14(1):1-18 [15128046] Mol Pharmacol. 2004 Jun;65(6):1397-404 [15155833] Drug Metab Dispos. 2004 Jul;32(7):727-33 [15205388] J Pharmacol Exp Ther. 2004 Sep;310(3):845-54 [15084647] Cancer Res. 2004 Oct 15;64(20):7197-200 [15492232] Biochem Biophys Res Commun. 1988 May 16;152(3):1269-74 [2837181] Circ Res. 1993 Jan;72(1):126-36 [8417836] J Biol Chem. 1993 Jun 15;268(17):12912-8 [8509425] Pharmacogenetics. 1994 Dec;4(6):285-99 [7704034] Mol Cell Biol. 1995 Aug;15(8):4158-66 [7623810] Am J Physiol. 1996 Oct;271(4 Pt 2):R863-9 [8897975] Br J Clin Pharmacol. 1998 Jun;45(6):525-38 [9663807] Arch Biochem Biophys. 1998 Sep 1;357(1):45-57 [9721182] Mol Cell Biol. 1998 Oct;18(10):5652-8 [9742082] Anal Biochem. 1998 Dec 1;265(1):55-68 [9866708] J Biol Chem. 1999 Mar 5;274(10):6043-6 [10037683] Am J Physiol. 1999 Jun;276(6 Pt 2):R1691-700 [10362749] J Biol Chem. 2004 Nov 19;279(47):49307-14 [15347657] Mol Pharmacol. 2005 Sep;68(3):747-57 [15933212] Clin Exp Pharmacol Physiol. 2006 Mar;33(3):183-8 [16487260] Toxicol Appl Pharmacol. 2006 Sep 15;215(3):274-84 [16730040] Drug Metab Dispos. 2006 Dec;34(12):2003-10 [16936065] Kidney Int. 2007 Sep;72(6):683-9 [17597703] FASEB J. 2009 Jan;23(1):224-31 [18794335] Expert Opin Drug Metab Toxicol. 2009 Jul;5(7):757-71 [19505190] Curr Drug Metab. 2009 Jul;10(6):567-78 [19702536] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/dmd.110.032334 ER - TY - JOUR T1 - Up-regulation of striatal adenosine A(2A) receptors with iron deficiency in rats: effects on locomotion and cortico-striatal neurotransmission. AN - 733337078; 20385128 AB - Brain iron deficiency leads to altered dopaminergic function in experimental animals, which can provide a mechanistic explanation for iron deficiency-related human sensory-motor disorders, such as Restless Legs Syndrome (RLS). However, mechanisms linking both conditions have not been determined. Considering the strong modulation exerted by adenosine on dopamine signaling, one connection could involve changes in adenosine receptor expression or function. In the striatum, presynaptic A(2A) receptors are localized in glutamatergic terminals contacting GABAergic dynorphinergic neurons and their function can be analyzed by the ability of A(2A) receptor antagonists to block the motor output induced by cortical electrical stimulation. Postsynaptic A(2A) receptors are localized in the dendritic field of GABAergic enkephalinergic neurons and their function can be analyzed by studying the ability of A(2A) receptor antagonists to produce locomotor activity and to counteract striatal ERK1/2 phosphorylation induced by cortical electrical stimulation. Increased density of striatal A(2A) receptors was found in rats fed during 3 weeks with an iron-deficient diet during the post-weaning period. In iron-deficient rats, the selective A(2A) receptor antagonist MSX-3, at doses of 1 and 3 mg/kg, was more effective at blocking motor output induced by cortical electrical stimulation (presynaptic A(2A) receptor-mediated effect) and at enhancing locomotor activation and blocking striatal ERK phosphorylation induced by cortical electrical stimulation (postsynaptic A(2A) receptor-mediated effects). These results indicate that brain iron deficiency induces a functional up-regulation of both striatal pre- and postsynaptic A(2A) receptor, which could be involved in sensory-motor disorders associated with iron deficiency such as RLS. Copyright 2010. Published by Elsevier Inc. JF - Experimental neurology AU - Quiroz, César AU - Pearson, Virginia AU - Gulyani, Seema AU - Allen, Richard AU - Earley, Christopher AU - Ferré, Sergi AD - National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA. quirozc@mail.nih.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 292 EP - 298 VL - 224 IS - 1 KW - Adenosine A2 Receptor Antagonists KW - 0 KW - MSX 3 compound KW - Receptor, Adenosine A2A KW - Receptors, Transferrin KW - Xanthines KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Animals KW - Synaptic Transmission -- drug effects KW - Neural Pathways -- physiology KW - Electromyography KW - Synaptic Transmission -- physiology KW - Electric Stimulation KW - Xanthines -- pharmacology KW - Neural Pathways -- drug effects KW - Receptors, Transferrin -- metabolism KW - Phosphorylation -- drug effects KW - Up-Regulation -- physiology KW - Rats KW - Rats, Sprague-Dawley KW - Blotting, Western KW - Exploratory Behavior -- drug effects KW - Phosphorylation -- physiology KW - Up-Regulation -- drug effects KW - Exploratory Behavior -- physiology KW - Male KW - Cerebral Cortex -- physiology KW - Cerebral Cortex -- drug effects KW - Corpus Striatum -- metabolism KW - Corpus Striatum -- drug effects KW - Motor Activity -- physiology KW - Motor Activity -- drug effects KW - Iron -- deficiency KW - Receptor, Adenosine A2A -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733337078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+neurology&rft.atitle=Up-regulation+of+striatal+adenosine+A%282A%29+receptors+with+iron+deficiency+in+rats%3A+effects+on+locomotion+and+cortico-striatal+neurotransmission.&rft.au=Quiroz%2C+C%C3%A9sar%3BPearson%2C+Virginia%3BGulyani%2C+Seema%3BAllen%2C+Richard%3BEarley%2C+Christopher%3BFerr%C3%A9%2C+Sergi&rft.aulast=Quiroz&rft.aufirst=C%C3%A9sar&rft.date=2010-07-01&rft.volume=224&rft.issue=1&rft.spage=292&rft.isbn=&rft.btitle=&rft.title=Experimental+neurology&rft.issn=1090-2430&rft_id=info:doi/10.1016%2Fj.expneurol.2010.04.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-28 N1 - Date created - 2010-06-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurology. 2000 Apr 25;54(8):1698-700 [10762522] J Nutr. 2000 Nov;130(11):2831-7 [11053528] Pharmacol Rev. 2001 Dec;53(4):527-52 [11734617] J Neurosci. 2002 Jun 15;22(12):5042-54 [12077200] Early Hum Dev. 2002 Dec;70(1-2):85-101 [12441207] J Nutr. 2003 May;133(5 Suppl 1):1468S-72S [12730445] Neuropsychopharmacology. 2003 Jul;28(7):1281-91 [12700682] Annu Rev Nutr. 2003;23:41-58 [12704220] Sleep Med. 2003 Mar;4(2):101-19 [14592341] Neurology. 2004 May 11;62(9):1563-7 [15136682] Parkinsonism Relat Disord. 2004 Jul;10(5):265-71 [15196504] Sleep Med. 2004 Jul;5(4):385-91 [15222997] Pharmacol Biochem Behav. 1980 Apr;12(4):493-502 [7393950] Adv Biochem Psychopharmacol. 1983;37:309-21 [6138953] Trends Neurosci. 1997 Oct;20(10):482-7 [9347617] J Nutr. 1997 Dec;127(12):2282-8 [9405575] Biol Signals Recept. 1998 May-Jun;7(3):157-78 [9672759] J Comp Neurol. 1998 Nov 16;401(2):163-86 [9822147] Neurology. 1999 Mar 23;52(5):1060-3 [10102429] Br J Phys Med. 1954 Jul;17(7):160-2 [13172443] Arch Intern Med. 2005 Jun 13;165(11):1286-92 [15956009] J Neurosci. 2006 Feb 15;26(7):2080-7 [16481441] Sleep Med. 2006 Aug;7(5):458-61 [16740411] J Neurosci. 2006 Oct 18;26(42):10808-12 [17050719] Semin Pediatr Neurol. 2006 Sep;13(3):158-65 [17101454] Brain Res Rev. 2007 Aug;55(1):55-67 [17408563] Prog Neurobiol. 2007 Dec;83(5):277-92 [17646043] Curr Pharm Des. 2008;14(15):1468-74 [18537670] J Nutr. 2008 Dec;138(12):2487-94 [19022977] Exp Neurol. 2009 Feb;215(2):236-42 [19013457] Neuropsychopharmacology. 2009 Mar;34(4):972-86 [18800071] Brain. 2009 Sep;132(Pt 9):2403-12 [19467991] ScientificWorldJournal. 2009;9:1321-44 [19936569] Pharmacol Biochem Behav. 2001 Jul-Aug;69(3-4):409-18 [11509198] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.expneurol.2010.04.004 ER - TY - JOUR T1 - Expression profiling identifies epoxy anthraquinone derivative as a DNA topoisomerase inhibitor. AN - 733302206; 20133050 AB - To discover novel drugs for neuroblastoma treatment, we have previously screened a panel of drugs and identified 30 active agents against neuroblastoma cells. Here we performed microarray gene expression analysis to monitor the impact of these agents on a neuroblastoma cell line and used the connectivity map (cMAP) to explore putative mechanism of action of unknown drugs. We first compared the expression profiles of 10 compounds shared in both our dataset and cMAP database and observed the high connectivity scores for 7 of 10 matched drugs regardless of the differences of cell lines utilized. The screen of cMAP for uncharacterized drugs indicated the signature of Epoxy anthraquinone derivative (EAD) matched the profiles of multiple known DNA targeted agents (topoisomerase I/II inhibitors, DNA intercalators, and DNA alkylation agents) as predicted by its structure. Similar result was obtained by querying against our internal NB-cMAP (http://pob.abcc.ncifcrf.gov/cgi-bin/cMAP), a database containing the profiles of 30 active drugs. These results suggest that Epoxy anthraquinone derivative may inhibit neuroblastoma cells by targeting DNA replication inhibition. Experimental data also demonstrate that Epoxy anthraquinone derivative indeed induces DNA double-strand breaks through DNA alkylation and inhibition of topoisomerase activity. Our study indicates that Epoxy anthraquinone derivative may be a novel DNA topoisomerase inhibitor that can be potentially used for treatment of neuroblastoma or other cancer patients. JF - Cancer letters AU - Gheeya, Jinesh AU - Johansson, Peter AU - Chen, Qing-Rong AU - Dexheimer, Thomas AU - Metaferia, Belhu AU - Song, Young K AU - Wei, Jun S AU - He, Jianbin AU - Pommier, Yves AU - Khan, Javed AD - Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, Gaithersburg, MD, USA. Y1 - 2010/07/01/ PY - 2010 DA - 2010 Jul 01 SP - 124 EP - 131 VL - 293 IS - 1 KW - Anthraquinones KW - 0 KW - DNA, Neoplasm KW - Enzyme Inhibitors KW - Epoxy Compounds KW - RNA, Messenger KW - Topoisomerase I Inhibitors KW - Topoisomerase II Inhibitors KW - Index Medicus KW - Gene Expression -- drug effects KW - Oligonucleotide Array Sequence Analysis KW - DNA Damage KW - Humans KW - Cell Line, Tumor KW - RNA, Messenger -- genetics KW - Alkylation -- drug effects KW - RNA, Messenger -- biosynthesis KW - DNA Replication -- drug effects KW - Gene Expression Profiling KW - Cell Survival -- drug effects KW - DNA, Neoplasm -- genetics KW - Databases, Genetic KW - Drug Screening Assays, Antitumor -- methods KW - DNA, Neoplasm -- biosynthesis KW - DNA, Neoplasm -- metabolism KW - Neuroblastoma -- genetics KW - Neuroblastoma -- drug therapy KW - Epoxy Compounds -- pharmacology KW - Anthraquinones -- pharmacology KW - Neuroblastoma -- enzymology KW - Enzyme Inhibitors -- pharmacology KW - Neuroblastoma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733302206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Expression+profiling+identifies+epoxy+anthraquinone+derivative+as+a+DNA+topoisomerase+inhibitor.&rft.au=Gheeya%2C+Jinesh%3BJohansson%2C+Peter%3BChen%2C+Qing-Rong%3BDexheimer%2C+Thomas%3BMetaferia%2C+Belhu%3BSong%2C+Young+K%3BWei%2C+Jun+S%3BHe%2C+Jianbin%3BPommier%2C+Yves%3BKhan%2C+Javed&rft.aulast=Gheeya&rft.aufirst=Jinesh&rft.date=2010-07-01&rft.volume=293&rft.issue=1&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=1872-7980&rft_id=info:doi/10.1016%2Fj.canlet.2010.01.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-21 N1 - Date created - 2010-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.canlet.2010.01.004 ER - TY - JOUR T1 - No role for human papillomavirus in esophageal squamous cell carcinoma in China. AN - 733295015; 19918949 AB - Certain regions of China have high rates of esophageal squamous cell carcinoma (ESCC). Previous studies of human papillomavirus (HPV), a proposed causal factor, have produced highly variable results. We attempted to evaluate HPV and ESCC more definitively using extreme care to prevent DNA contamination. We collected tissue and serum in China from 272 histopathologically-confirmed ESCC cases with rigorous attention to good molecular biology technique. We tested for HPV DNA in fresh-frozen tumor tissue using PCR with PGMY L1 consensus primers and HPV16 and 18 type-specific E6 and E7 primers, and in formalin-fixed paraffin-embedded tumor tissue using SPF(10) L1 primers. In HPV-positive cases, we evaluated p16(INK4a) overexpression and HPV E6/E7 seropositivity as evidence of carcinogenic HPV activity. beta-globin, and thus DNA, was adequate in 98.2% of the frozen tumor tissues (267/272). Of these, 99.6% (95% confidence interval (CI) = 97.9-100.0%) were negative for HPV DNA by PGMY, and 100% (95% CI = 98.6-100%) were negative by HPV16/18 E6/E7 PCR. In the corresponding formalin-fixed paraffin-embedded tumor specimens, 99.3% (95% CI = 97.3-99.9%) were HPV negative by SPF(10). By PGMY, 1 case tested weakly positive for HPV89, a noncancer causing HPV type. By SPF(10), 2 cases tested weakly positive: 1 for HPV16 and 1 for HPV31. No HPV DNA-positive case had evidence of HPV oncogene activity as measured by p16(INK4a) overexpression or E6/E7 seropositivity. This study provides the most definitive evidence to date that HPV is not involved in ESCC carcinogenesis in China. HPV DNA contamination cannot be ruled out as an explanation for high HPV prevalence in ESCC tissue studies with less stringent tissue procurement and processing protocols. JF - International journal of cancer AU - Koshiol, Jill AU - Wei, Wen-Qiang AU - Kreimer, Aimee R AU - Chen, Wen AU - Gravitt, Patti AU - Ren, Jian-Song AU - Abnet, Christian C AU - Wang, Jian-Bing AU - Kamangar, Farin AU - Lin, Dong-Mei AU - von Knebel-Doeberitz, Magnus AU - Zhang, Yu AU - Viscidi, Raphael AU - Wang, Guo-Qing AU - Gillison, Maura L AU - Roth, Mark J AU - Dong, Zhi-Wei AU - Kim, Esther AU - Taylor, Philip R AU - Qiao, You-Lin AU - Dawsey, Sanford M AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852-7248, USA. koshiolj@mail.nih.gov Y1 - 2010/07/01/ PY - 2010 DA - 2010 Jul 01 SP - 93 EP - 100 VL - 127 IS - 1 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Humans KW - Aged KW - Middle Aged KW - DNA, Viral -- genetics KW - Male KW - Female KW - China KW - Papillomaviridae -- pathogenicity KW - Esophageal Neoplasms -- virology KW - Carcinoma, Squamous Cell -- pathology KW - Papillomaviridae -- genetics KW - Carcinoma, Squamous Cell -- virology KW - Esophageal Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733295015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=No+role+for+human+papillomavirus+in+esophageal+squamous+cell+carcinoma+in+China.&rft.au=Koshiol%2C+Jill%3BWei%2C+Wen-Qiang%3BKreimer%2C+Aimee+R%3BChen%2C+Wen%3BGravitt%2C+Patti%3BRen%2C+Jian-Song%3BAbnet%2C+Christian+C%3BWang%2C+Jian-Bing%3BKamangar%2C+Farin%3BLin%2C+Dong-Mei%3Bvon+Knebel-Doeberitz%2C+Magnus%3BZhang%2C+Yu%3BViscidi%2C+Raphael%3BWang%2C+Guo-Qing%3BGillison%2C+Maura+L%3BRoth%2C+Mark+J%3BDong%2C+Zhi-Wei%3BKim%2C+Esther%3BTaylor%2C+Philip+R%3BQiao%2C+You-Lin%3BDawsey%2C+Sanford+M&rft.aulast=Koshiol&rft.aufirst=Jill&rft.date=2010-07-01&rft.volume=127&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.25023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-14 N1 - Date created - 2010-05-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Infect Dis. 2004 Feb 15;189(4):686-98 [14767823] Am J Epidemiol. 2007 Jun 15;165(12):1424-33 [17420181] J Med Virol. 2004 Sep;74(1):107-16 [15258976] Am J Obstet Gynecol. 2004 Sep;191(3):757-61 [15467536] Obstet Gynecol. 1989 Dec;74(6):950-4 [2555753] Cancer Epidemiol Biomarkers Prev. 1994 Jun;3(4):341-7 [8061584] Zhonghua Zhong Liu Za Zhi. 1995 Sep;17(5):321-4 [8697965] J Clin Microbiol. 1998 Feb;36(2):475-80 [9466762] Hum Pathol. 1998 Mar;29(3):266-71 [9496830] J Clin Microbiol. 1998 Oct;36(10):3020-7 [9738060] Am J Pathol. 1998 Dec;153(6):1731-9 [9846964] Am J Pathol. 1998 Dec;153(6):1741-8 [9846965] Int J Cancer. 1999 Apr 12;81(2):225-8 [10188723] J Clin Microbiol. 1999 Aug;37(8):2508-17 [10405393] J Pathol. 1999 Sep;189(1):12-9 [10451482] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] Anticancer Res. 2008 Mar-Apr;28(2B):1133-8 [18505048] J Clin Microbiol. 2008 Oct;46(10):3437-45 [18716224] Cancer. 2008 Nov 15;113(10 Suppl):3036-46 [18980286] Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008 Aug;22(4):251-3 [19105334] Lancet Oncol. 2009 Apr;10(4):321-2 [19350698] Cancer Causes Control. 2009 Nov;20(9):1705-13 [19705288] Sex Transm Infect. 1999 Oct;75(5):317-9 [10616355] J Clin Microbiol. 2000 Jan;38(1):357-61 [10618116] Scand J Gastroenterol. 2000 Feb;35(2):123-30 [10720108] J Natl Cancer Inst. 2000 Nov 1;92(21):1753-63 [11058618] Int J Cancer. 2001 Apr 15;92(2):276-84 [11291057] Carcinogenesis. 2001 Jun;22(6):929-34 [11375901] J Immunol Methods. 2001 Jul 1;253(1-2):153-62 [11384677] J Clin Pathol. 2002 Oct;55(10):721-8 [12354793] Int J Cancer. 2002 Nov 20;102(3):271-4 [12397650] Eur J Cancer. 2002 Nov;38(17):2229-42 [12441259] Int J Cancer. 2003 Feb 10;103(4):496-500 [12478665] N Engl J Med. 2003 Feb 6;348(6):518-27 [12571259] J Natl Cancer Inst Monogr. 2003;(31):57-65 [12807947] J Natl Cancer Inst Monogr. 2003;(31):80-8 [12807950] Arch Pathol Lab Med. 2003 Aug;127(8):940-5 [12873165] J Natl Cancer Inst. 2003 Sep 17;95(18):1414-6 [13130117] Sex Transm Infect. 2003 Oct;79(5):426-7 [14573848] J Natl Cancer Inst. 2003 Dec 3;95(23):1772-83 [14652239] Int J Cancer. 2005 Jan 20;113(3):456-63 [15455378] J Natl Cancer Inst. 2005 Feb 16;97(4):301-6 [15713965] Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):467-75 [15734974] Int J Epidemiol. 2005 Apr;34(2):467-74 [15659476] Carcinogenesis. 2005 Jul;26(7):1280-4 [15774487] Int J Cancer. 2006 Aug 1;119(3):579-84 [16496409] Int J Cancer. 2006 Sep 15;119(6):1354-9 [16615110] N Engl J Med. 2007 May 10;356(19):1944-56 [17494927] J Clin Microbiol. 2004 Jul;42(7):3176-84 [15243079] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.25023 ER - TY - JOUR T1 - Epigallocatechin-3-gallate (EGCG) downregulates gelatinase-B (MMP-9) by involvement of FAK/ERK/NFkappaB and AP-1 in the human breast cancer cell line MDA-MB-231. AN - 733232002; 20527725 AB - Epigallocatechin-3-gallate (EGCG) is effective against the initiation, progression, and invasion of carcinogenesis.Matrix-metalloproteinases (MMPs) are a family of endopeptidases that hydrolyze the majority of extracellular proteins. MMP-9 is one of the most important members of the family and we observed the effect of EGCG on MMP-9 in the human breast cancer cell line, MDA-MB-231.The effect of EGCG on MMP-9 was studied by gelatin zymography, western blot, quantitative and semiquantitative real-time RT-PCR, immunoflourescence, cell adhesion assay, enzyme-linked immunosorbent assay,and electrophoretic mobility shift assay. EGCG treatment reduced the activity, protein, and mRNA expression ofMMP-9 and enhanced the expression of the tissue inhibitor of MMP 1 (TIMP-1). EGCG downregulated the activation of focal adhesion kinase (FAK) and extracellular regulated kinase (ERK), reduced the adhesion of MDA-MB-231 cells to fibronectin and vitronectin, and reduced the mRNA expression of the integrin receptors alpha5beta1 and alphavbeta3. The expression of the nuclear factor kappa B (NFjB), and the DNA binding activity of NFjB and activator protein 1 (AP1)to MMP-9 promoter were noticeably reduced on EGCG treatment. Upregulation of TIMP-1 and disruption of the functional status of integrin receptors may indicate decreased MMP-9 activation; inhibition of FAK andERK activation might indicate disruption in the FAK/ERK-induced MMP-9 secretion and induction. Decreased DNA binding activity of NFjB and AP1 to MMP-9 promoter might indicate transcriptional deregulation of MMP-9 gene on EGCG treatment. We propose EGCG as a potential inhibitor of the expression and activity of MMP-9 by a process involving FAK/ERK and transcription factorsin MDA-MB-231. JF - Anti-cancer drugs AU - Sen, Triparna AU - Dutta, Anindita AU - Chatterjee, Amitava AD - Department of Receptor Biology and Tumor Metastasis, Chittaranjan National Cancer Institute, 37 S P Mukherjee Road, Kolkata 700026, West Bengal, India. Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 632 EP - 644 VL - 21 IS - 6 KW - Anticarcinogenic Agents KW - 0 KW - Carrier Proteins KW - Extracellular Matrix Proteins KW - NF-kappa B KW - RNA, Messenger KW - Tissue Inhibitor of Metalloproteinase-1 KW - Transcription Factor AP-1 KW - Catechin KW - 8R1V1STN48 KW - epigallocatechin gallate KW - BQM438CTEL KW - Focal Adhesion Protein-Tyrosine Kinases KW - EC 2.7.10.2 KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - Matrix Metalloproteinase 9 KW - EC 3.4.24.35 KW - Index Medicus KW - Carrier Proteins -- antagonists & inhibitors KW - Transcription Factor AP-1 -- metabolism KW - Humans KW - Cell Line, Tumor KW - Extracellular Signal-Regulated MAP Kinases -- metabolism KW - Extracellular Matrix Proteins -- metabolism KW - Cell Survival -- drug effects KW - RNA, Messenger -- metabolism KW - Focal Adhesion Protein-Tyrosine Kinases -- metabolism KW - Tissue Inhibitor of Metalloproteinase-1 -- metabolism KW - Signal Transduction -- drug effects KW - Cell Movement -- drug effects KW - Down-Regulation -- drug effects KW - Female KW - Matrix Metalloproteinase 9 -- metabolism KW - Catechin -- analogs & derivatives KW - Anticarcinogenic Agents -- pharmacology KW - Breast Neoplasms -- metabolism KW - Breast Neoplasms -- enzymology KW - Catechin -- pharmacology KW - NF-kappa B -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733232002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-cancer+drugs&rft.atitle=Epigallocatechin-3-gallate+%28EGCG%29+downregulates+gelatinase-B+%28MMP-9%29+by+involvement+of+FAK%2FERK%2FNFkappaB+and+AP-1+in+the+human+breast+cancer+cell+line+MDA-MB-231.&rft.au=Sen%2C+Triparna%3BDutta%2C+Anindita%3BChatterjee%2C+Amitava&rft.aulast=Sen&rft.aufirst=Triparna&rft.date=2010-07-01&rft.volume=21&rft.issue=6&rft.spage=632&rft.isbn=&rft.btitle=&rft.title=Anti-cancer+drugs&rft.issn=1473-5741&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-21 N1 - Date created - 2010-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Saffron suppresses oxidative stress in DMBA-induced skin carcinoma: A histopathological study. AN - 733136055; 19328523 AB - Cancer chemoprevention is the use of natural, synthetic or biological substances to reverse or prevent the development of cancer. Saffron is a naturally derived plant product that acts as an antispasmodic, diaphoretic, carminative, emmenagogic and sedative. Our aim in this study was to investigate the chemopreventive effect of aqueous saffron on chemically induced skin carcinogenesis using a histopathological approach. Mice were divided into five groups: carcinogen control (CC), normal control (NC) and saffron-treated Groups A, B and C. Groups A, B, C and CC mice received three topical applications of 7,12 dimethylbenz[a]anthracene (DMBA) followed by croton oil on shaven dorsal skin for 8 weeks. NC mice received topical skin applications of the vehicle, acetone, only. Saffron infusion was fed orally to three groups of mice either before (Group A) or after (Group C) or both before and after (Group B) DMBA applications. The activities of antioxidant enzymes glutathione-S transferase (GST), glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) in liver tissue samples taken at 0, 6, 10 and 12 weeks from all groups were assessed. Standard histological examination of skin demonstrated a beneficial action of saffron in mice where saffron treatments were given both before and after the induction of skin carcinogenesis. Saffron ingestion inhibited the formation of skin papillomas in animals and simultaneously reduced their size. In conclusion, saffron inhibits DMBA-induced skin carcinoma in mice when treated early. This may be due, at least in part, to the induction of cellular defense systems. Copyright 2009 Elsevier GmbH. All rights reserved. JF - Acta histochemica AU - Das, Ila AU - Das, Sukta AU - Saha, Tapas AD - Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, Kolkata, India. Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 317 EP - 327 VL - 112 IS - 4 KW - Plant Extracts KW - 0 KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Index Medicus KW - Skin Neoplasms -- drug therapy KW - Animals KW - Papilloma -- pathology KW - Skin Neoplasms -- pathology KW - Mice KW - Skin Neoplasms -- metabolism KW - Papilloma -- drug therapy KW - Papilloma -- metabolism KW - Female KW - Plant Extracts -- pharmacology KW - Crocus -- chemistry KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - Oxidative Stress -- drug effects KW - Plant Extracts -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733136055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+histochemica&rft.atitle=Saffron+suppresses+oxidative+stress+in+DMBA-induced+skin+carcinoma%3A+A+histopathological+study.&rft.au=Das%2C+Ila%3BDas%2C+Sukta%3BSaha%2C+Tapas&rft.aulast=Das&rft.aufirst=Ila&rft.date=2010-07-01&rft.volume=112&rft.issue=4&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Acta+histochemica&rft.issn=1618-0372&rft_id=info:doi/10.1016%2Fj.acthis.2009.02.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-25 N1 - Date created - 2010-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.acthis.2009.02.003 ER - TY - JOUR T1 - The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. AN - 733120991; 20361964 AB - Quercetin, a member of the flavonoid family, is one of the most prominent dietary antioxidants. This study investigates the mechanisms for the effects of quercetin on cultured human RPE cells and in Ccl2/Cx3cr1 double knock-out (DKO) mice, which spontaneously develop progressive retinal lesions mimicking age-related macular degeneration (AMD). In the in vitro experiment, cultured ARPE-19 cells were exposed to 1 mM H(2)O(2) with or without 50 muM quercetin for 2 h. Cellular viability, mitochondrial function, and apoptosis were assessed using crystal violet staining, MTT assay, and comet assay, respectively. Apoptotic molecular transcripts of BCL-2, BAX, FADD, CASPASE-3 and CASPASE-9 were measured by RQ-PCR. COX activity and nitric oxide (NO) level were determined in the supernatant of the culture medium. Quercetin treatment protected ARPE-19 cells from H(2)O(2)-induced oxidative injury, enhanced BCL-2 transcript levels, increased the BCL-2/BAX ratio, suppressed the transcription of pro-apoptotic factors such as BAX, FADD, CASPASE-3 and CASPASE-9, inhibited the transcription of inflammatory factors such as TNF-alpha, COX-2 and INOS, and decreased the levels of COX and NO in the culture medium. In the in vivo experiment, DKO and C57/B6 mice were treated with 25 mg/kg/day quercetin by intraperitoneal injection daily for two months. Funduscopy was performed monthly. After two months, serum was collected to measure NADP(+)/NADPH, COX, PGE-2, and NO levels. The eyes were harvested for histology and A2E measurement. Ocular transcripts of Bcl-2, Bax, Cox-2, Inos, Tnf-alpha, Fas, FasL and Caspase-3 were detected by RQ-PCR. Quercetin treatment did not reverse the progression of retinal lesions in DKO mice funduscopically or histologically. Although quercetin treatment could recover systemic anti-oxidative capacity, suppress the systemic expression of NO, COX and PGE-2, and decrease ocular A2E levels, it could not effectively suppress the transcripts of the ocular inflammatory factors Tnf-alpha, Cox-2 and Inos, or the pro-apoptotic factors Fas, FasL and Caspase-3 in DKO mice. Our data demonstrate that quercetin can protect human RPE cells from oxidative stress in vitro via inhibition of pro-inflammatory molecules and direct inhibition of the intrinsic apoptosis pathway. However, quercetin (25 mg/kg/day) does not improve the retinal AMD-like lesions in the Ccl2(-/-)/Cx3cr1(-/-) mice, likely due to its insufficient suppression of the inflammatory and apoptosis pathways in the eye. Published by Elsevier Ltd. JF - Experimental eye research AU - Cao, Xiaoguang AU - Liu, Melissa AU - Tuo, Jingsheng AU - Shen, Defen AU - Chan, Chi-Chao AD - Immunopathology Section, Laboratory of Immunology; National Eye Institute, National Institutes of Health, Bethesda, MD 20892-1857, USA. Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 15 EP - 25 VL - 91 IS - 1 KW - Antioxidants KW - 0 KW - Apoptosis Regulatory Proteins KW - Ccl2 protein, mouse KW - Chemokine CCL2 KW - Cx3cr1 protein, mouse KW - Receptors, Chemokine KW - Nitric Oxide KW - 31C4KY9ESH KW - Quercetin KW - 9IKM0I5T1E KW - Hydrogen Peroxide KW - BBX060AN9V KW - Prostaglandin-Endoperoxide Synthases KW - EC 1.14.99.1 KW - Caspases KW - EC 3.4.22.- KW - Dinoprostone KW - K7Q1JQR04M KW - Index Medicus KW - Mitochondria -- physiology KW - Animals KW - Humans KW - Nitric Oxide -- metabolism KW - Disease Models, Animal KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Caspases -- metabolism KW - Mice, Knockout KW - Cell Survival KW - Hydrogen Peroxide -- toxicity KW - Cells, Cultured KW - Prostaglandin-Endoperoxide Synthases -- metabolism KW - Dinoprostone -- metabolism KW - Apoptosis -- drug effects KW - Apoptosis Regulatory Proteins -- metabolism KW - Mice, Inbred C57BL KW - Macular Degeneration -- prevention & control KW - Antioxidants -- pharmacology KW - Macular Degeneration -- genetics KW - Oxidative Stress KW - Receptors, Chemokine -- physiology KW - Retinal Pigment Epithelium -- drug effects KW - Chemokine CCL2 -- physiology KW - Macular Degeneration -- metabolism KW - Retinal Pigment Epithelium -- pathology KW - Quercetin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733120991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+eye+research&rft.atitle=The+effects+of+quercetin+in+cultured+human+RPE+cells+under+oxidative+stress+and+in+Ccl2%2FCx3cr1+double+deficient+mice.&rft.au=Cao%2C+Xiaoguang%3BLiu%2C+Melissa%3BTuo%2C+Jingsheng%3BShen%2C+Defen%3BChan%2C+Chi-Chao&rft.aulast=Cao&rft.aufirst=Xiaoguang&rft.date=2010-07-01&rft.volume=91&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Experimental+eye+research&rft.issn=1096-0007&rft_id=info:doi/10.1016%2Fj.exer.2010.03.016 LA - 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Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.exer.2010.03.016 ER - TY - JOUR T1 - Leg Symptom Categories and Rates of Mobility Decline in Peripheral Arterial Disease AN - 1505332816; 19159169 AB - OBJECTIVES: To determine whether asymptomatic lower extremity peripheral arterial disease (PAD) and leg symptoms other than intermittent claudication (IC) in PAD are associated with faster functional decline than in people with both PAD and IC. DESIGN: Prospective, observational study. PARTICIPANTS: Four hundred fifteen people with PAD followed annually for up to 7 years. MEASUREMENTS: At baseline, patients with PAD were categorized into symptom categories, including IC; leg pain on exertion and rest; participants who could walk through exertional leg pain (pain/carry on); and participants who never experienced exertional leg pain, even during the 6-minute walk (always asymptomatic). Outcomes included mobility loss (becoming unable to walk one-quarter of a mile or walk up and down one flight of stairs without assistance) and becoming unable to complete the 6-minute walk without stopping. Analyses adjusted for age, sex, comorbidities, ankle brachial index, and other confounders. RESULTS: Always-asymptomatic participants (hazard ratio (HR)=2.94, 95% confidence interval (CI)=1.39-6.19, P=.005) and those with leg pain on exertion and rest (HR=2.89, 95% CI=1.47-5.68, P=.002) had greater mobility loss than participants with IC. Participants with PAD with leg pain/carry on were less likely (P=.047) to become unable to walk for 6 minutes continuously without stopping than participants with IC. CONCLUSION: The ABI identifies patients with asymptomatic PAD and those with atypical leg symptoms who are at risk for greater mobility decline than participants without PAD and participants with PAD with IC.Original Abstract: SETTING: Chicago-area medical center. JF - Journal of the American Geriatrics Society AU - McDermott, Mary M AU - Ferrucci, Luigi AU - Liu, Kiang AU - Guralnik, Jack M AU - Tian, Lu AU - Liao, Yihua AU - Criqui, Michael H AD - From the Departments of*Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland; Stanford University, Palo Alto, California; and [par]University of California at San Diego, San Diego, California. Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 1256 EP - 1262 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 7 SN - 0002-8614, 0002-8614 KW - Risk Abstracts KW - Age KW - Pain KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1505332816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Leg+Symptom+Categories+and+Rates+of+Mobility+Decline+in+Peripheral+Arterial+Disease&rft.au=McDermott%2C+Mary+M%3BFerrucci%2C+Luigi%3BLiu%2C+Kiang%3BGuralnik%2C+Jack+M%3BTian%2C+Lu%3BLiao%2C+Yihua%3BCriqui%2C+Michael+H&rft.aulast=McDermott&rft.aufirst=Mary&rft.date=2010-07-01&rft.volume=58&rft.issue=7&rft.spage=1256&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2010.02941.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-03-01 N1 - Document feature - figure 3 N1 - Last updated - 2014-03-10 N1 - SubjectsTermNotLitGenreText - Pain DO - http://dx.doi.org/10.1111/j.1532-5415.2010.02941.x ER - TY - JOUR T1 - Disparities in Influenza Vaccine Coverage in the United States, 2008 AN - 1500759991; 19159156 AB - OBJECTIVES: To determine the distribution of influenza vaccine coverage in the United States in 2008. SETTING: The 2008 Behavioral Risk Factor Surveillance Survey, which employs random-digit dialing to interview noninstitutionalized adults in the United States and territories. PARTICIPANTS: Two hundred forty-nine thousand seven hundred twenty-three persons aged 50 and older. MEASUREMENTS: Participants were asked whether they had had an influenza vaccination during the previous 12 months. RESULTS: In 2008, 42.0% of adults aged 50 to 64 and 69.5% of adults aged 65 and older reported receiving an influenza vaccination in the past 12 months. Vaccine coverage generally increased with advancing age (P<.001), higher levels of education (P<.001) and total household income (P<.001), and greater morbidity (P<.001). In participants aged 50 to 64, vaccine prevalence was lower in men (39.9%) than in women (44.1%; P<.001), although no significant differences were observed in older adults. Within each 5-year interval of age, non-Hispanic blacks and Hispanics had significantly lower vaccine prevalence than non-Hispanic whites (P<.001 for all comparisons). For participants aged 65 and older, non-Hispanic blacks and Hispanics were 56% (adjusted prevalence ratio (PR)=1.56, 95% confidence interval (CI)=1.48, 1.64) and 44% (adjusted PR=1.44, 95% CI=1.35, 1.54) more likely, respectively, to be unvaccinated than non-Hispanic whites, adjusting for age and sex. Racial and ethnic disparities in vaccine coverage narrowed with increasing number of diseases, although these disparities remained significant in older adults with two or more diseases (P<.05). CONCLUSION: There were large disparities in influenza vaccine coverage in 2008, particularly across race and ethnicity and socioeconomic position. Accordingly, more targeted interventions are needed to improve vaccine delivery to disadvantaged segments of the U.S. population.Original Abstract: DESIGN: Cross-sectional analysis. JF - Journal of the American Geriatrics Society AU - Linn, Shauna T AU - Guralnik, Jack M AU - Patel, Kushang V AD - From the*Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institute of Health, Bethesda, Maryland; and Johns Hopkins University, Baltimore, Maryland. Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 1333 EP - 1340 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 7 SN - 0002-8614, 0002-8614 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Risk Abstracts KW - Age KW - Intervention KW - Socioeconomics KW - Territory KW - Morbidity KW - Income KW - Influenza KW - Risk factors KW - Geriatrics KW - Ethnic groups KW - Races KW - Vaccination KW - Socio-economic aspects KW - USA KW - Education KW - Households KW - Vaccines KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1500759991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Disparities+in+Influenza+Vaccine+Coverage+in+the+United+States%2C+2008&rft.au=Linn%2C+Shauna+T%3BGuralnik%2C+Jack+M%3BPatel%2C+Kushang+V&rft.aulast=Linn&rft.aufirst=Shauna&rft.date=2010-07-01&rft.volume=58&rft.issue=7&rft.spage=1333&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2010.02904.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-01 N1 - Document feature - figure 1 N1 - Last updated - 2014-06-26 N1 - SubjectsTermNotLitGenreText - Influenza; Socio-economic aspects; Age; Risk factors; Geriatrics; Territory; Vaccines; Vaccination; Races; Ethnic groups; Morbidity; Education; Households; Socioeconomics; Intervention; Income; USA DO - http://dx.doi.org/10.1111/j.1532-5415.2010.02904.x ER - TY - JOUR T1 - American Journal of Botany AN - 1464885992; 2013-095200 JF - American Journal of Botany AU - Boyce, C Kevin AU - Hotton, Carol L Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 1073 PB - Botanical Society of America, St. Louis, MO VL - 97 IS - 7 SN - 0002-9122, 0002-9122 KW - Plantae KW - liverwort mats KW - Paleozoic KW - biogenic structures KW - ichnofossils KW - microbial mats KW - Bryophyta KW - Ontario KW - genesis KW - problematic fossils KW - Prototaxites KW - fungi KW - cylindrical structures KW - Canada KW - anatomy KW - upper Paleozoic KW - taphonomy KW - Hepaticae KW - Eastern Canada KW - sedimentary structures KW - rolled mats KW - 06A:Sedimentary petrology KW - 09:Paleobotany UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1464885992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Botany&rft.atitle=American+Journal+of+Botany&rft.au=Boyce%2C+C+Kevin%3BHotton%2C+Carol+L&rft.aulast=Boyce&rft.aufirst=C&rft.date=2010-07-01&rft.volume=97&rft.issue=7&rft.spage=1073&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Botany&rft.issn=00029122&rft_id=info:doi/10.3732%2Fajb.1000104 L2 - http://www.jstor.org/journals/00029122.html LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2013-01-01 N1 - Number of references - 4 N1 - PubXState - MO N1 - SuppNotes - For reference to original see Graham, L. E., et. al., Am. J. Bot., Vol. 97, No. 2, p. 268-275, 2010; DOI: 10.3732/ajb.0900322 N1 - Last updated - 2013-12-05 N1 - CODEN - AJBOAA N1 - SubjectsTermNotLitGenreText - anatomy; biogenic structures; Bryophyta; Canada; cylindrical structures; Eastern Canada; fungi; genesis; Hepaticae; ichnofossils; liverwort mats; microbial mats; Ontario; Paleozoic; Plantae; problematic fossils; Prototaxites; rolled mats; sedimentary structures; taphonomy; upper Paleozoic DO - http://dx.doi.org/10.3732/ajb.1000104 ER - TY - JOUR T1 - Real-time optical imaging using quantum dot and related nanocrystals AN - 1034817086; 17053354 AB - Biomedical optical imaging is rapidly evolving because of its desirable features of rapid frame rates, high sensitivity, low cost, portability and lack of radiation. Quantum dots are attractive as imaging agents owing to their high brightness, and photo- and bio-stability. Here, the current status of in vitro and in vivo real-time optical imaging with quantum dots is reviewed. In addition, we consider related nanocrystals based on solid-state semiconductors, including upconverting nanoparticles and bioluminescence resonance energy transfer quantum dots. These particles can improve the signal-to-background ratio for real-time imaging largely by suppressing background signal. Although toxicity and biodistribution of quantum dots and their close relatives remain prime concerns for translation to human imaging, these agents have many desirable features that should be explored for medical purposes. JF - Nanomedicine AU - Kosaka, Nobuyuki AU - McCann, Thomas E AU - Mitsunaga, Makoto AU - Choyke, Peter L AU - Kobayashi, Hisataka AD - super(1)Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr., Bethesda, MD 20892-1088, USA, kobayash@mail.nih.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 765 EP - 776 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 5 IS - 5 SN - 1743-5889, 1743-5889 KW - Biotechnology and Bioengineering Abstracts KW - Bioluminescence KW - Brightness KW - Crystals KW - Quantum dots KW - Radiation KW - Reviews KW - Toxicity KW - Translation KW - imaging KW - nanoparticles KW - nanotechnology KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034817086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanomedicine&rft.atitle=Real-time+optical+imaging+using+quantum+dot+and+related+nanocrystals&rft.au=Kosaka%2C+Nobuyuki%3BMcCann%2C+Thomas+E%3BMitsunaga%2C+Makoto%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Kosaka&rft.aufirst=Nobuyuki&rft.date=2010-07-01&rft.volume=5&rft.issue=5&rft.spage=765&rft.isbn=&rft.btitle=&rft.title=Nanomedicine&rft.issn=17435889&rft_id=info:doi/10.2217%2Fnnm.10.49 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Number of references - 81 N1 - Last updated - 2012-09-10 N1 - SubjectsTermNotLitGenreText - Translation; Radiation; Brightness; Bioluminescence; Quantum dots; Reviews; Toxicity; Crystals; nanoparticles; imaging; nanotechnology DO - http://dx.doi.org/10.2217/nnm.10.49 ER - TY - JOUR T1 - Data analysis in flow cytometry: The future just started AN - 1017973904; 16714584 AB - In the last 10 years, a tremendous progress characterized flow cytometry in its different aspects. In particular, major advances have been conducted regarding the hardware/instrumentation and reagent development, thus allowing fine cell analysis up to 20 parameters. As a result, this technology generates very complex datasets that demand for the development of optimal tools of analysis. Recently, many independent research groups approached the problem by using both supervised and unsupervised methods. In this article, we will review the new developments concerning the use of bioinformatics for polychromatic flow cytometry and propose what should be done to unravel the enormous heterogeneity of the cells we interrogate each day. Published 2010 Wiley-Liss,Inc. JF - Cytometry Part A AU - Lugli, Enrico AU - Roederer, Mario AU - Cossarizza, Andrea AD - Immuno Technology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, luglie@mail.nih.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 705 EP - 713 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 77A IS - 7 SN - 1552-4930, 1552-4930 KW - Biotechnology and Bioengineering Abstracts KW - Bioinformatics KW - Data processing KW - Development KW - Flow cytometry KW - Reviews KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017973904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+A&rft.atitle=Data+analysis+in+flow+cytometry%3A+The+future+just+started&rft.au=Lugli%2C+Enrico%3BRoederer%2C+Mario%3BCossarizza%2C+Andrea&rft.aulast=Lugli&rft.aufirst=Enrico&rft.date=2010-07-01&rft.volume=77A&rft.issue=7&rft.spage=705&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+A&rft.issn=15524930&rft_id=info:doi/10.1002%2Fcyto.a.20901 L2 - http://onlinelibrary.wiley.com/doi/10.1002/cyto.a.20901/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Data processing; Reviews; Bioinformatics; Development DO - http://dx.doi.org/10.1002/cyto.a.20901 ER - TY - JOUR T1 - Good cell, bad cell: Flow cytometry reveals T-cell subsets important in HIV disease AN - 1017973773; 16714575 AB - Flow cytometry is a key technology in the study of HIV disease. In this article, we review various cellular markers that can be measured in the setting of pathogenesis or vaccination studies, including markers of activation, differentiation, senescence, immune suppression, and function. In addition, we discuss important considerations for making these measurements. Finally, we examine how flow cytometry studies have taught researchers about the disease process, and the potential for flow cytometry technology to guide treatment decisions and evaluate vaccine candidates in the future. Published 2010 Wiley-Liss, Inc. JF - Cytometry Part A AU - Chattopadhyay, Pratip K AU - Roederer, Mario Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 614 EP - 622 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 77A IS - 7 SN - 1552-4930, 1552-4930 KW - Biotechnology and Bioengineering Abstracts KW - Differentiation KW - Flow cytometry KW - Lymphocytes T KW - Reviews KW - Senescence KW - Vaccination KW - Vaccines KW - Human immunodeficiency virus KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017973773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+A&rft.atitle=Good+cell%2C+bad+cell%3A+Flow+cytometry+reveals+T-cell+subsets+important+in+HIV+disease&rft.au=Chattopadhyay%2C+Pratip+K%3BRoederer%2C+Mario&rft.aulast=Chattopadhyay&rft.aufirst=Pratip&rft.date=2010-07-01&rft.volume=77A&rft.issue=7&rft.spage=614&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+A&rft.issn=15524930&rft_id=info:doi/10.1002%2Fcyto.a.20905 L2 - http://onlinelibrary.wiley.com/doi/10.1002/cyto.a.20905/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Differentiation; Reviews; Lymphocytes T; Senescence; Vaccines; Vaccination; Human immunodeficiency virus DO - http://dx.doi.org/10.1002/cyto.a.20905 ER - TY - JOUR T1 - Diabetes in relation to biliary tract cancer and stones: a population-based study in Shanghai, China AN - 745937667; 13188213 AB - Background:Biliary tract cancers are rare but fatal malignancies. Diabetes has been related to biliary stones, but its association with biliary tract cancers is less conclusive. Methods:In a population-based case-control study of 627 cancers, 1037 stones, and 959 controls in Shanghai, China, we examined the association between diabetes and the risks of biliary tract cancer and stones, as well as the effect of potential mediating factors, including serum lipids and biliary stones (for cancer), contributing to the causal pathway from diabetes to biliary diseases. Results:Independent of body mass index (BMI), diabetes was significantly associated with gallbladder cancer and biliary stones ((odds ratio (OR) (95% confidence interval)=2.6 (1.5-4.7) and 2.0 (1.2-3.3), respectively). Biliary stones and low serum levels of high-density lipoprotein (HDL) were significant mediators of the diabetes effect on gallbladder cancer risk, accounting for 60 and 17% of the diabetes effect, respectively. High-density lipoprotein was also a significant mediator of the diabetes effect on biliary stones, accounting for 18% of the diabetes effect. Conclusions:Independent of BMI, diabetes is a risk factor for gallbladder cancer, but its effect is mediated in part by biliary stones and serum HDL levels, suggesting that gallbladder cancer risk may be reduced by controlling diabetes, stones, and HDL levels. JF - British Journal of Cancer AU - Shebl, F M AU - Andreotti, G AU - Rashid, A AU - Gao, Y-T AU - Yu, K AU - Shen, M-C AU - Wang, B-S AU - Li, Q AU - Han, T-Q AU - Zhang, B-H AU - Fraumeni, J F AU - Hsing, A W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA Y1 - 2010/06/29/ PY - 2010 DA - 2010 Jun 29 SP - 115 EP - 119 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 103 IS - 1 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - diabetes mellitus KW - body mass KW - Lipids KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745937667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Diabetes+in+relation+to+biliary+tract+cancer+and+stones%3A+a+population-based+study+in+Shanghai%2C+China&rft.au=Shebl%2C+F+M%3BAndreotti%2C+G%3BRashid%2C+A%3BGao%2C+Y-T%3BYu%2C+K%3BShen%2C+M-C%3BWang%2C+B-S%3BLi%2C+Q%3BHan%2C+T-Q%3BZhang%2C+B-H%3BFraumeni%2C+J+F%3BHsing%2C+A+W&rft.aulast=Shebl&rft.aufirst=F&rft.date=2010-06-29&rft.volume=103&rft.issue=1&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605706 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - diabetes mellitus; body mass; Lipids; Cancer; China, People's Rep., Shanghai; China, People's Rep. DO - http://dx.doi.org/10.1038/sj.bjc.6605706 ER - TY - JOUR T1 - Insulin-like growth factors and risk of kidney cancer in men AN - 745937641; 13188221 AB - Background:Insulin-like growth factor-I (IGF-I) has been shown to increase kidney growth, glomerular filtration rate, and renal function. Methods:In the prospective Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) study of 29133 Finnish male smokers aged 50-69 years, serum concentrations of IGF were measured in samples collected in 1985-1988. A total of 100 men with kidney cancer diagnosed .5 years after blood collection through 1997 were compared with a subcohort of 400 men; logistic regression models were used to estimate the risk of developing kidney cancer. Results:Men with IGF-I levels >113ngml super(-1) were 59% less likely to develop kidney cancer than men with levels ,113ngml super(-1) (odds ratio=0.41; 95% confidence interval=0.23-0.75). The IGF binding protein-3 (IGFBP-3) levels did not alter the association. No association was observed between IGFBP-3, or molar ratio of IGF-I/IGFBP-3, and kidney cancer. Conclusions:Low serum IGF-I levels in this cohort of older middle-aged male smokers are associated with increased kidney cancer risk, independent of IGFBP-3. JF - British Journal of Cancer AU - Major, J M AU - Pollak, M N AU - Snyder, K AU - Virtamo, J AU - Albanes, D AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20852, USA Y1 - 2010/06/29/ PY - 2010 DA - 2010 Jun 29 SP - 132 EP - 135 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 103 IS - 1 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Filtration KW - renal function KW - Kidney KW - prevention KW - males KW - growth factors KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745937641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Insulin-like+growth+factors+and+risk+of+kidney+cancer+in+men&rft.au=Major%2C+J+M%3BPollak%2C+M+N%3BSnyder%2C+K%3BVirtamo%2C+J%3BAlbanes%2C+D&rft.aulast=Major&rft.aufirst=J&rft.date=2010-06-29&rft.volume=103&rft.issue=1&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605722 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Filtration; renal function; prevention; Kidney; males; growth factors; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6605722 ER - TY - CPAPER T1 - Novel cellular mechanisms of resistance to platinum chemotherapeutics T2 - 2010 Gordon Research Conference on Metals in Medicine AN - 839674675; 5940006 JF - 2010 Gordon Research Conference on Metals in Medicine AU - Gottesman, Michael Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Platinum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839674675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Metals+in+Medicine&rft.atitle=Novel+cellular+mechanisms+of+resistance+to+platinum+chemotherapeutics&rft.au=Gottesman%2C+Michael&rft.aulast=Gottesman&rft.aufirst=Michael&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Metals+in+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=metalsmed LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - The Health Services Research Agenda and Funding Opportunities of the National Institutes of Health T2 - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AN - 839634210; 5888957 JF - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AU - Chambers, David AU - Clauser, Steven AU - Cook, Nakela AU - Duffy, Sarah Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839634210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.atitle=The+Health+Services+Research+Agenda+and+Funding+Opportunities+of+the+National+Institutes+of+Health&rft.au=Chambers%2C+David%3BClauser%2C+Steven%3BCook%2C+Nakela%3BDuffy%2C+Sarah&rft.aulast=Chambers&rft.aufirst=David&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/Events/content.cfm?ItemNumber=2625&navIte LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - The plasmodial surface anion channel: cloning and validation as an antimalarial target T2 - 2010 Gordon Research Conference on Host-Parasite Interactions, Biology Of AN - 839608264; 5877837 JF - 2010 Gordon Research Conference on Host-Parasite Interactions, Biology Of AU - Desai, Sanjay Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Anion channels KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839608264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Host-Parasite+Interactions%2C+Biology+Of&rft.atitle=The+plasmodial+surface+anion+channel%3A+cloning+and+validation+as+an+antimalarial+target&rft.au=Desai%2C+Sanjay&rft.aulast=Desai&rft.aufirst=Sanjay&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Host-Parasite+Interactions%2C+Biology+Of&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=hostpara LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Linking Stress Responses with Small Membrane Proteins T2 - 2010 Gordon Research Conference on Bacterial Cell Surfaces AN - 839606646; 5877404 JF - 2010 Gordon Research Conference on Bacterial Cell Surfaces AU - Storz, Gisela Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Stress KW - Membrane proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839606646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Bacterial+Cell+Surfaces&rft.atitle=Linking+Stress+Responses+with+Small+Membrane+Proteins&rft.au=Storz%2C+Gisela&rft.aulast=Storz&rft.aufirst=Gisela&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Bacterial+Cell+Surfaces&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=bactcell LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Development of fluorescent proteins for single molecule localization techniques T2 - Gordon Research Conference on Single Molecule Approaches To Biology AN - 839606058; 5877576 JF - Gordon Research Conference on Single Molecule Approaches To Biology AU - Patterson, George Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Proteins KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839606058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Gordon+Research+Conference+on+Single+Molecule+Approaches+To+Biology&rft.atitle=Development+of+fluorescent+proteins+for+single+molecule+localization+techniques&rft.au=Patterson%2C+George&rft.aulast=Patterson&rft.aufirst=George&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Gordon+Research+Conference+on+Single+Molecule+Approaches+To+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=singlemol LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - New approaches to understanding the B cell response to malaria T2 - 2010 Gordon Research Conference on Host-Parasite Interactions, Biology Of AN - 839603881; 5877850 JF - 2010 Gordon Research Conference on Host-Parasite Interactions, Biology Of AU - Crompton, Peter Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Malaria KW - Lymphocytes B KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839603881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Host-Parasite+Interactions%2C+Biology+Of&rft.atitle=New+approaches+to+understanding+the+B+cell+response+to+malaria&rft.au=Crompton%2C+Peter&rft.aulast=Crompton&rft.aufirst=Peter&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Host-Parasite+Interactions%2C+Biology+Of&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=hostpara LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Genetic variation and genetic mapping genes contributing to drug response and virulence in malaria parasites T2 - 2010 Gordon Research Conference on Host-Parasite Interactions, Biology Of AN - 839603805; 5877814 JF - 2010 Gordon Research Conference on Host-Parasite Interactions, Biology Of AU - Su, Xin-zhuan Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Parasites KW - Gene mapping KW - Malaria KW - Drugs KW - Genetic diversity KW - Virulence KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839603805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Host-Parasite+Interactions%2C+Biology+Of&rft.atitle=Genetic+variation+and+genetic+mapping+genes+contributing+to+drug+response+and+virulence+in+malaria+parasites&rft.au=Su%2C+Xin-zhuan&rft.aulast=Su&rft.aufirst=Xin-zhuan&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Host-Parasite+Interactions%2C+Biology+Of&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=hostpara LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Plasmodium falciparum Gametocytogenesis T2 - 2010 Gordon Research Conference on Host-Parasite Interactions, Biology Of AN - 839603762; 5877805 JF - 2010 Gordon Research Conference on Host-Parasite Interactions, Biology Of AU - Morahan, Belinda Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Parasites KW - {Q2} KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839603762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Host-Parasite+Interactions%2C+Biology+Of&rft.atitle=Plasmodium+falciparum+Gametocytogenesis&rft.au=Morahan%2C+Belinda&rft.aulast=Morahan&rft.aufirst=Belinda&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Host-Parasite+Interactions%2C+Biology+Of&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=hostpara LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Absence of Cypb Causes Recessive Oi with Normal Peptidyl-Prolyl Isomerization T2 - 37th European Symposium on Calcified Tissues (ECTS 2010) AN - 839685862; 5941333 JF - 37th European Symposium on Calcified Tissues (ECTS 2010) AU - Barnes, A AU - Cabral, W AU - Chang, W AU - Makareeva, E AU - Leikin, S AU - Carter, E AU - Raggio, C AU - Weis, M AU - Eyre, D AU - Marini, J Y1 - 2010/06/26/ PY - 2010 DA - 2010 Jun 26 KW - {Q1} KW - Isomerization KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839685862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=37th+European+Symposium+on+Calcified+Tissues+%28ECTS+2010%29&rft.atitle=Absence+of+Cypb+Causes+Recessive+Oi+with+Normal+Peptidyl-Prolyl+Isomerization&rft.au=Barnes%2C+A%3BCabral%2C+W%3BChang%2C+W%3BMakareeva%2C+E%3BLeikin%2C+S%3BCarter%2C+E%3BRaggio%2C+C%3BWeis%2C+M%3BEyre%2C+D%3BMarini%2C+J&rft.aulast=Barnes&rft.aufirst=A&rft.date=2010-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=37th+European+Symposium+on+Calcified+Tissues+%28ECTS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://ects2010.abstractsondemand.com/perday.php?congress=ECTS2010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - A Founder Mutation in lepre1 Causes Lethal Recessive Type Viii Osteogenesis Imperfecta and Occurs in West Africans and African Americans T2 - 37th European Symposium on Calcified Tissues (ECTS 2010) AN - 839682881; 5941582 JF - 37th European Symposium on Calcified Tissues (ECTS 2010) AU - Cabral, W AU - Barnes, A AU - Porter, F AU - Marini, J AU - Chitayat, D AU - Panny, S AU - Rebbeck, T AU - Tishkoff, S AU - Bailey-Wilson, J AU - Brody, L AU - Rotimi, C Y1 - 2010/06/26/ PY - 2010 DA - 2010 Jun 26 KW - {Q1} KW - Africa KW - Mutation KW - Ethnic groups KW - Osteogenesis imperfecta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839682881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=37th+European+Symposium+on+Calcified+Tissues+%28ECTS+2010%29&rft.atitle=A+Founder+Mutation+in+lepre1+Causes+Lethal+Recessive+Type+Viii+Osteogenesis+Imperfecta+and+Occurs+in+West+Africans+and+African+Americans&rft.au=Cabral%2C+W%3BBarnes%2C+A%3BPorter%2C+F%3BMarini%2C+J%3BChitayat%2C+D%3BPanny%2C+S%3BRebbeck%2C+T%3BTishkoff%2C+S%3BBailey-Wilson%2C+J%3BBrody%2C+L%3BRotimi%2C+C&rft.aulast=Cabral&rft.aufirst=W&rft.date=2010-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=37th+European+Symposium+on+Calcified+Tissues+%28ECTS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://ects2010.abstractsondemand.com/perday.php?congress=ECTS2010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - STAT1:STAT3 Cross-regulation in Patients with Defective Interferon Gamma Signaling T2 - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AN - 839696521; 5932528 JF - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AU - Bax, Hannelore AU - Kristosturyan, Ervand AU - Browne, Sarah AU - Ding, Li AU - Holland, Steven AU - Sampaio, Elizabeth Y1 - 2010/06/24/ PY - 2010 DA - 2010 Jun 24 KW - {Q1} KW - G-Interferon KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839696521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.atitle=STAT1%3ASTAT3+Cross-regulation+in+Patients+with+Defective+Interferon+Gamma+Signaling&rft.au=Bax%2C+Hannelore%3BKristosturyan%2C+Ervand%3BBrowne%2C+Sarah%3BDing%2C+Li%3BHolland%2C+Steven%3BSampaio%2C+Elizabeth&rft.aulast=Bax&rft.aufirst=Hannelore&rft.date=2010-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/2010_focis_sci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - HIV Vaccinology: What Does the Future Hold? T2 - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AN - 839694462; 5932082 JF - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AU - Fauci, Anthony Y1 - 2010/06/24/ PY - 2010 DA - 2010 Jun 24 KW - {Q1} KW - Human immunodeficiency virus KW - {Q2} KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839694462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.atitle=HIV+Vaccinology%3A+What+Does+the+Future+Hold%3F&rft.au=Fauci%2C+Anthony&rft.aulast=Fauci&rft.aufirst=Anthony&rft.date=2010-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/2010_focis_sci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Variations of Vaccinia Virus' Replication in Melanoma and Lung Cell Lines Based on Different Expression of IFI6, and IFTMN2 and beta-microglobin T2 - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AN - 839694127; 5932314 JF - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AU - Ascierto, Maria AU - Pos, Zoltan AU - Wang, Ena AU - Marincola, Francesco AU - Worschech, Andrea AU - Ascierto, Paolo AU - Rossano, Fabio Y1 - 2010/06/24/ PY - 2010 DA - 2010 Jun 24 KW - {Q1} KW - Melanoma KW - Lung KW - Replication KW - {Q2} KW - Vaccinia virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839694127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.atitle=Variations+of+Vaccinia+Virus%27+Replication+in+Melanoma+and+Lung+Cell+Lines+Based+on+Different+Expression+of+IFI6%2C+and+IFTMN2+and+beta-microglobin&rft.au=Ascierto%2C+Maria%3BPos%2C+Zoltan%3BWang%2C+Ena%3BMarincola%2C+Francesco%3BWorschech%2C+Andrea%3BAscierto%2C+Paolo%3BRossano%2C+Fabio&rft.aulast=Ascierto&rft.aufirst=Maria&rft.date=2010-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/2010_focis_sci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Intraocular Inflammatory Disease in Systemic Mucosal Disorders T2 - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AN - 839693990; 5932097 JF - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AU - Nida Sen, H Y1 - 2010/06/24/ PY - 2010 DA - 2010 Jun 24 KW - {Q1} KW - Mucosa KW - Inflammatory diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839693990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.atitle=Intraocular+Inflammatory+Disease+in+Systemic+Mucosal+Disorders&rft.au=Nida+Sen%2C+H&rft.aulast=Nida+Sen&rft.aufirst=H&rft.date=2010-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/2010_focis_sci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - TL1A-DR3 Interactions are Important in Both Adaptive and Innate Immunity in Inflammatory Arthritis T2 - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AN - 839693812; 5932381 JF - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AU - Song, Yun-Jeong AU - Meylan, Francoise AU - Botson, John AU - Goldbach-Mansky, Raphaela AU - Siegel, Richard AU - Lee, David Y1 - 2010/06/24/ PY - 2010 DA - 2010 Jun 24 KW - {Q1} KW - Immunity KW - Arthritis KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839693812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.atitle=TL1A-DR3+Interactions+are+Important+in+Both+Adaptive+and+Innate+Immunity+in+Inflammatory+Arthritis&rft.au=Song%2C+Yun-Jeong%3BMeylan%2C+Francoise%3BBotson%2C+John%3BGoldbach-Mansky%2C+Raphaela%3BSiegel%2C+Richard%3BLee%2C+David&rft.aulast=Song&rft.aufirst=Yun-Jeong&rft.date=2010-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/2010_focis_sci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - The Role of Double Negative T Cells in U T2 - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AN - 839687539; 5932253 JF - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AU - Nida Sen, H AU - Liu, Baoying AU - Wei, Lai AU - Hu, Mengjun AU - Jawad, Shayma AU - Chakrabarty, Sagarika AU - Nussenblatt, Robert Y1 - 2010/06/24/ PY - 2010 DA - 2010 Jun 24 KW - {Q1} KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839687539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.atitle=The+Role+of+Double+Negative+T+Cells+in+U&rft.au=Nida+Sen%2C+H%3BLiu%2C+Baoying%3BWei%2C+Lai%3BHu%2C+Mengjun%3BJawad%2C+Shayma%3BChakrabarty%2C+Sagarika%3BNussenblatt%2C+Robert&rft.aulast=Nida+Sen&rft.aufirst=H&rft.date=2010-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/2010_focis_sci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - HIV/SIV Vaccine Efficacy Dependent on the Dose of SIVmac251 Challenge Exposure in Macaques T2 - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AN - 839687473; 5932214 JF - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AU - Franchini, Genoveffa Y1 - 2010/06/24/ PY - 2010 DA - 2010 Jun 24 KW - {Q1} KW - Human immunodeficiency virus KW - Vaccines KW - Disease control KW - {Q2} KW - Simian immunodeficiency virus KW - Macaca KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839687473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.atitle=HIV%2FSIV+Vaccine+Efficacy+Dependent+on+the+Dose+of+SIVmac251+Challenge+Exposure+in+Macaques&rft.au=Franchini%2C+Genoveffa&rft.aulast=Franchini&rft.aufirst=Genoveffa&rft.date=2010-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/2010_focis_sci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - The Impact of Race on Interferon-alpha Responsiveness: A Genome-wide Study T2 - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AN - 839687463; 5932254 JF - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AU - Pos, Zoltan AU - Thomas, Jaime AU - Spivey, Tara AU - Liu, Hui AU - Sabatino, Marianna AU - Monaco, Alessandro AU - Alter, Harvey AU - Wang, Ena AU - Marincola, Francesco AU - Selleri, Silvia AU - Wang, Jeanne AU - Worschech, Andrea AU - Falus, Andras Y1 - 2010/06/24/ PY - 2010 DA - 2010 Jun 24 KW - {Q1} KW - A-Interferon KW - Races KW - Subpopulations KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839687463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.atitle=The+Impact+of+Race+on+Interferon-alpha+Responsiveness%3A+A+Genome-wide+Study&rft.au=Pos%2C+Zoltan%3BThomas%2C+Jaime%3BSpivey%2C+Tara%3BLiu%2C+Hui%3BSabatino%2C+Marianna%3BMonaco%2C+Alessandro%3BAlter%2C+Harvey%3BWang%2C+Ena%3BMarincola%2C+Francesco%3BSelleri%2C+Silvia%3BWang%2C+Jeanne%3BWorschech%2C+Andrea%3BFalus%2C+Andras&rft.aulast=Pos&rft.aufirst=Zoltan&rft.date=2010-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/2010_focis_sci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Common Variants of the Class I Major Histocompatibility Complex, IL10, CPLX1, and IL23R Genes Predispose to Behcet's Disease in the Turkish Population T2 - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AN - 839685668; 5932138 JF - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AU - Yang, Barbara AU - Remmers, Elaine AU - Kirino, Yohei AU - Ombrello, Michael AU - O'Shea, John AU - Gadina, Massimo AU - Kastner, Daniel AU - Cosan, Fulya AU - Gul, Ahmet Y1 - 2010/06/24/ PY - 2010 DA - 2010 Jun 24 KW - {Q1} KW - Interleukin 10 KW - Major histocompatibility complex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839685668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.atitle=Common+Variants+of+the+Class+I+Major+Histocompatibility+Complex%2C+IL10%2C+CPLX1%2C+and+IL23R+Genes+Predispose+to+Behcet%27s+Disease+in+the+Turkish+Population&rft.au=Yang%2C+Barbara%3BRemmers%2C+Elaine%3BKirino%2C+Yohei%3BOmbrello%2C+Michael%3BO%27Shea%2C+John%3BGadina%2C+Massimo%3BKastner%2C+Daniel%3BCosan%2C+Fulya%3BGul%2C+Ahmet&rft.aulast=Yang&rft.aufirst=Barbara&rft.date=2010-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/2010_focis_sci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Ocular Autoimmunity in the Face of a Combined Defect in Th1 and Th17 Effector Responses T2 - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AN - 839685450; 5932218 JF - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AU - Damsker, Jesse AU - Luger, Dror AU - Silver, Phyllis AU - Chan, Chi-Chao AU - Caspi, Rachel AU - Iwakura, Yoichiro Y1 - 2010/06/24/ PY - 2010 DA - 2010 Jun 24 KW - {Q1} KW - Lymphocytes T KW - Helper cells KW - Autoimmunity KW - Defects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839685450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.atitle=Ocular+Autoimmunity+in+the+Face+of+a+Combined+Defect+in+Th1+and+Th17+Effector+Responses&rft.au=Damsker%2C+Jesse%3BLuger%2C+Dror%3BSilver%2C+Phyllis%3BChan%2C+Chi-Chao%3BCaspi%2C+Rachel%3BIwakura%2C+Yoichiro&rft.aulast=Damsker&rft.aufirst=Jesse&rft.date=2010-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/2010_focis_sci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Lymphopenia and Adoptive Immunotherapy: Friend or Foe? T2 - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AN - 839685416; 5932204 JF - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AU - Mackall, Crystal Y1 - 2010/06/24/ PY - 2010 DA - 2010 Jun 24 KW - {Q1} KW - Immunotherapy KW - Adoptive immunotherapy KW - Lymphopenia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839685416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.atitle=Lymphopenia+and+Adoptive+Immunotherapy%3A+Friend+or+Foe%3F&rft.au=Mackall%2C+Crystal&rft.aulast=Mackall&rft.aufirst=Crystal&rft.date=2010-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/2010_focis_sci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - microRNA-181a: A Potential Regulator of Effector CD4 + T Cell Phenotype T2 - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AN - 839684770; 5932197 JF - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AU - Deng, Min AU - Arias, Marco AU - Ramaswamy, Madhu AU - Siegel, Richard Y1 - 2010/06/24/ PY - 2010 DA - 2010 Jun 24 KW - {Q1} KW - MiRNA KW - Lymphocytes T KW - CD4 antigen KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839684770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.atitle=microRNA-181a%3A+A+Potential+Regulator+of+Effector+CD4+%2B+T+Cell+Phenotype&rft.au=Deng%2C+Min%3BArias%2C+Marco%3BRamaswamy%2C+Madhu%3BSiegel%2C+Richard&rft.aulast=Deng&rft.aufirst=Min&rft.date=2010-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/2010_focis_sci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Identification of a Novel STAT1 Dominant Negative Mutation Characterizes Decreased Activation in Response to Interferon Gamma T2 - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AN - 839673805; 5932548 JF - 2010 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2010) AU - Elloumi, Houda AU - Paulson, Michelle AU - Ding, Li AU - Gulbu, Uzel AU - Kristosturyan, Ervand AU - Bax, Hannelore AU - Sampaio, Elizabeth AU - Holland, Steven Y1 - 2010/06/24/ PY - 2010 DA - 2010 Jun 24 KW - {Q1} KW - Mutation KW - G-Interferon KW - Stat1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839673805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.atitle=Identification+of+a+Novel+STAT1+Dominant+Negative+Mutation+Characterizes+Decreased+Activation+in+Response+to+Interferon+Gamma&rft.au=Elloumi%2C+Houda%3BPaulson%2C+Michelle%3BDing%2C+Li%3BGulbu%2C+Uzel%3BKristosturyan%2C+Ervand%3BBax%2C+Hannelore%3BSampaio%2C+Elizabeth%3BHolland%2C+Steven&rft.aulast=Elloumi&rft.aufirst=Houda&rft.date=2010-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/2010_focis_sci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Activity in the primary visual cortex related to visual awareness T2 - 14th annual meeting of the Association for the Scientific Study of Consciousness (ASSC 14) AN - 839655285; 5898563 JF - 14th annual meeting of the Association for the Scientific Study of Consciousness (ASSC 14) AU - Maier, Alexander Y1 - 2010/06/24/ PY - 2010 DA - 2010 Jun 24 KW - {Q1} KW - Visual perception KW - Cortex (visual) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839655285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+annual+meeting+of+the+Association+for+the+Scientific+Study+of+Consciousness+%28ASSC+14%29&rft.atitle=Activity+in+the+primary+visual+cortex+related+to+visual+awareness&rft.au=Maier%2C+Alexander&rft.aulast=Maier&rft.aufirst=Alexander&rft.date=2010-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+annual+meeting+of+the+Association+for+the+Scientific+Study+of+Consciousness+%28ASSC+14%29&rft.issn=&rft_id=info:doi/ L2 - http://www.theassc.org/files/assc/Full_ASSC_Program_With_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Hallmarks of Alzheimer'S Disease in Senescence Accelerated Mice p8: An in Vivo and in Vitro Approach T2 - 1st International Congress on Controversies in Longevity, Health and Aging (CoLONGY 2010) AN - 839641274; 5910992 JF - 1st International Congress on Controversies in Longevity, Health and Aging (CoLONGY 2010) AU - Pallas, M AU - Cristofol, R AU - Gutierrez-Cuesta, J AU - Garcia-Matas, S AU - Tajes, M AU - deCabo, R AU - Camins, A AU - Coto-Montes, A AU - Sanfeliu, C Y1 - 2010/06/24/ PY - 2010 DA - 2010 Jun 24 KW - {Q1} KW - Senescence KW - Alzheimer's disease KW - Mice KW - Neurodegenerative diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839641274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=1st+International+Congress+on+Controversies+in+Longevity%2C+Health+and+Aging+%28CoLONGY+2010%29&rft.atitle=Hallmarks+of+Alzheimer%27S+Disease+in+Senescence+Accelerated+Mice+p8%3A+An+in+Vivo+and+in+Vitro+Approach&rft.au=Pallas%2C+M%3BCristofol%2C+R%3BGutierrez-Cuesta%2C+J%3BGarcia-Matas%2C+S%3BTajes%2C+M%3BdeCabo%2C+R%3BCamins%2C+A%3BCoto-Montes%2C+A%3BSanfeliu%2C+C&rft.aulast=Pallas&rft.aufirst=M&rft.date=2010-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=1st+International+Congress+on+Controversies+in+Longevity%2C+Health+and+Aging+%28CoLONGY+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.comtecmed.com/colongy/2010/posterpresentation.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - JOUR T1 - Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. AN - 733300727; 20440268 AB - Limited information is available regarding epigenomic events mediating initiation and progression of tobacco-induced lung cancers. In this study, we established an in vitro system to examine epigenomic effects of cigarette smoke in respiratory epithelia. Normal human small airway epithelial cells and cdk-4/hTERT-immortalized human bronchial epithelial cells (HBEC) were cultured in normal media with or without cigarette smoke condensate (CSC) for up to 9 months under potentially relevant exposure conditions. Western blot analysis showed that CSC mediated dose- and time-dependent diminution of H4K16Ac and H4K20Me3, while increasing relative levels of H3K27Me3; these histone alterations coincided with decreased DNA methyltransferase 1 (DNMT1) and increased DNMT3b expression. Pyrosequencing and quantitative RT-PCR experiments revealed time-dependent hypomethylation of D4Z4, NBL2, and LINE-1 repetitive DNA sequences; up-regulation of H19, IGF2, MAGE-A1, and MAGE-A3; activation of Wnt signaling; and hypermethylation of tumor suppressor genes such as RASSF1A and RAR-beta, which are frequently silenced in human lung cancers. Array-based DNA methylation profiling identified additional novel DNA methylation targets in soft-agar clones derived from CSC-exposed HBEC; a CSC gene expression signature was also identified in these cells. Progressive genomic hypomethylation and locoregional DNA hypermethylation induced by CSC coincided with a dramatic increase in soft-agar clonogenicity. Collectively, these data indicate that cigarette smoke induces 'cancer-associated' epigenomic alterations in cultured respiratory epithelia. This in vitro model may prove useful for delineating early epigenetic mechanisms regulating gene expression during pulmonary carcinogenesis. JF - Oncogene AU - Liu, F AU - Killian, J K AU - Yang, M AU - Walker, R L AU - Hong, J A AU - Zhang, M AU - Davis, S AU - Zhang, Y AU - Hussain, M AU - Xi, S AU - Rao, M AU - Meltzer, P A AU - Schrump, D S AD - Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. Y1 - 2010/06/24/ PY - 2010 DA - 2010 Jun 24 SP - 3650 EP - 3664 VL - 29 IS - 25 KW - Histones KW - 0 KW - Smoke KW - Wnt Proteins KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Cell Line, Tumor KW - Bronchi -- drug effects KW - Bronchi -- pathology KW - Wnt Proteins -- metabolism KW - Tobacco -- toxicity KW - Bronchi -- cytology KW - Histones -- metabolism KW - Signal Transduction -- drug effects KW - DNA Methylation -- drug effects KW - Lung Neoplasms -- genetics KW - Bronchi -- metabolism KW - Lung Neoplasms -- metabolism KW - Lung Neoplasms -- pathology KW - Smoke -- adverse effects KW - Gene Expression Profiling KW - Respiratory Mucosa -- metabolism KW - Respiratory Mucosa -- cytology KW - Epigenesis, Genetic -- drug effects KW - Respiratory Mucosa -- drug effects KW - Smoking -- adverse effects KW - Respiratory Mucosa -- pathology KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733300727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Epigenomic+alterations+and+gene+expression+profiles+in+respiratory+epithelia+exposed+to+cigarette+smoke+condensate.&rft.au=Liu%2C+F%3BKillian%2C+J+K%3BYang%2C+M%3BWalker%2C+R+L%3BHong%2C+J+A%3BZhang%2C+M%3BDavis%2C+S%3BZhang%2C+Y%3BHussain%2C+M%3BXi%2C+S%3BRao%2C+M%3BMeltzer%2C+P+A%3BSchrump%2C+D+S&rft.aulast=Liu&rft.aufirst=F&rft.date=2010-06-24&rft.volume=29&rft.issue=25&rft.spage=3650&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2010.129 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-16 N1 - Date created - 2010-06-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/onc.2010.129 ER - TY - JOUR T1 - Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice AN - 759307429; 13070383 AB - Hippocampal neurogenesis can be regulated by extrinsic factors, such as exercise and antidepressants. While there is evidence that the selective serotonin reuptake inhibitor (SSRI) fluoxetine enhances neurogenesis, the new dual serotonergic-noradrenergic reuptake inhibitor (SNRI) duloxetine has not been evaluated in this context. In addition, it is unclear whether effects of antidepressants and running on cell genesis and behavior are of similar magnitude in mice. Here, we assessed neurogenesis and open-field behavior in 2-month-old female C57Bl/6 mice after 28days of treatment with either fluoxetine (18mg/kg), duloxetine (2, 6 or 18mg/kg) or exercise. New cell survival, as measured by 5-bromo-2a super(2)-deoxyuridine (BrdU)-labeled cells, was enhanced by 200% in the running group only. Both running and fluoxetine, but not duloxetine, increased the percentage of new cells that became neurons. In the open-field test, animals treated with either drug spent less time in the center than controls and runners. In addition, fluoxetine treatment resulted in reduced locomotor activity. Together, these data show that the neurogenic response to exercise is much stronger than to antidepressants and imply a low likelihood that anxiolytic effects of these drugs are mediated by adult neurogenesis in C57Bl/6 mice. JF - Brain Research AU - Marlatt, Michael W AU - Lucassen, Paul J AU - van Praag, Henriette AD - Swammerdam Institute for Life Science-Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands, vanpraagh@mail.nih.gov Y1 - 2010/06/23/ PY - 2010 DA - 2010 Jun 23 SP - 93 EP - 99 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1341 SN - 0006-8993, 0006-8993 KW - Physical Education Index; CSA Neurosciences Abstracts; Animal Behavior Abstracts KW - Neurogenesis KW - Duloxetine KW - Fluoxetine KW - Exercise KW - Hippocampus KW - Open field KW - Cell survival KW - Measurement KW - Data processing KW - Animal subjects KW - Running KW - Brain KW - Serotonin uptake inhibitors KW - Adults KW - Physical training KW - Anxiolytics KW - Antidepressants KW - Behavior KW - Locomotor activity KW - Running (effects) KW - Open-field behavior KW - Drugs KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25080:Orientation, Migration and Locomotion KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759307429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Research&rft.atitle=Comparison+of+neurogenic+effects+of+fluoxetine%2C+duloxetine+and+running+in+mice&rft.au=Marlatt%2C+Michael+W%3BLucassen%2C+Paul+J%3Bvan+Praag%2C+Henriette&rft.aulast=Marlatt&rft.aufirst=Michael&rft.date=2010-06-23&rft.volume=1341&rft.issue=&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Brain+Research&rft.issn=00068993&rft_id=info:doi/10.1016%2Fj.brainres.2010.03.086 LA - English DB - Physical Education Index N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Measurement; Behavior; Running; Animal subjects; Brain; Running (effects); Adults; Exercise; Drugs; Cell survival; Data processing; Hippocampus; Serotonin uptake inhibitors; Duloxetine; Physical training; Fluoxetine; Anxiolytics; Antidepressants; Neurogenesis; Locomotor activity; Open-field behavior DO - http://dx.doi.org/10.1016/j.brainres.2010.03.086 ER - TY - JOUR T1 - Utilization of serologic assays to support efficacy of vaccines in nonclinical and clinical trials: Meeting at the Crossroads AN - 754539983; 13253741 AB - In May 2009 the National Institute of Allergy and Infectious Diseases hosted a workshop on serologic assays that support vaccine efficacy evaluations. The meeting promoted exchange of ideas among investigators from varying disciplines who are working on anti-infectious agent vaccines at different stages of development. The presentations and discussions at the workshop illustrated the challenges common across various pathogens with recurring themes: (1) A thorough understanding of the science regarding the pathogen and the host response to disease and immunization is fundamental to assay selection. (2) The intended use of the immunoassay data must be clearly defined to ensure appropriate specificity, accuracy, and precision; a laboratory must also commit resources to assure data quality and reliability. (3) During vaccine development, an immunoassay may evolve with respect to quality, purpose, and degree of standardization, and, in some cases, must be changed or replaced as data are accumulated. (4) Collaboration on standardized reagents and methods, harmonization efforts, and multidisciplinary teams facilitate consistent generation of quality data. This report provides guidance for effective development and utilization of immunoassays based on the lessons learned from currently licensed vaccines. Investigators are encouraged to create additional opportunities for scientific exchange, noting that the discussed themes are relevant for immunoassays used for other purposes such as therapeutics and diagnostics. JF - Vaccine AU - Madore, Dace V AU - Meade, Bruce D AU - Rubin, Fran AU - Deal, Carolyn AU - Lynn, Freyja AD - Madore Medical Writing, LLC, Pittsford, NY 14534, United States, lynnf@niaid.nih.gov Y1 - 2010/06/23/ PY - 2010 DA - 2010 Jun 23 SP - 4539 EP - 4547 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 28 IS - 29 SN - 0264-410X, 0264-410X KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Standardization KW - Hypersensitivity KW - Data processing KW - Conferences KW - Infectious diseases KW - Developmental stages KW - Vaccines KW - Pathogens KW - Immunoassays KW - Clinical trials KW - Immunization KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754539983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Utilization+of+serologic+assays+to+support+efficacy+of+vaccines+in+nonclinical+and+clinical+trials%3A+Meeting+at+the+Crossroads&rft.au=Madore%2C+Dace+V%3BMeade%2C+Bruce+D%3BRubin%2C+Fran%3BDeal%2C+Carolyn%3BLynn%2C+Freyja&rft.aulast=Madore&rft.aufirst=Dace&rft.date=2010-06-23&rft.volume=28&rft.issue=29&rft.spage=4539&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2010.04.094 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Standardization; Hypersensitivity; Data processing; Infectious diseases; Conferences; Developmental stages; Pathogens; Vaccines; Clinical trials; Immunoassays; Immunization DO - http://dx.doi.org/10.1016/j.vaccine.2010.04.094 ER - TY - JOUR T1 - Targeting Mitochondrial Cell Death Pathway to Overcome Drug Resistance with a Newly Developed Iron Chelate AN - 745644335; 13205572 AB - Multi drug resistance (MDR) or cross-resistance to multiple classes of chemotherapeutic agents is a major obstacle to successful application of chemotherapy and a basic problem in cancer biology. The multidrug resistance gene, MDR1, and its gene product P-glycoprotein (P-gp) are an important determinant of MDR. Therefore, there is an urgent need for development of novel compounds that are not substrates of P-glycoprotein and are effective against drug-resistant cancer. In this present study, we have synthesized a novel, redox active Fe (II) complex (chelate), iron N- (2-hydroxy acetophenone) glycinate (FeNG). The structure of the complex has been determined by spectroscopic means. To evaluate the cytotoxic effect of FeNG we used doxorubicin resistant and/or sensitive T lymphoblastic leukemia cells and show that FeNG kills both the cell types irrespective of their MDR phenotype. Moreover, FeNG induces apoptosis in doxorubicin resistance T lymphoblastic leukemia cell through mitochondrial pathway via generation reactive oxygen species (ROS). This is substantiated by the fact that the antioxidant N-acetyle-cysteine (NAC) could completely block ROS generation and, subsequently, abrogated FeNG induced apoptosis. Therefore, FeNG induces the doxorubicin resistant T lymphoblastic leukemia cells to undergo apoptosis and thus overcome MDR. Our study provides evidence that FeNG, a redox active metal chelate may be a promising new therapeutic agent against drug resistance cancers. JF - PLoS ONE AU - Ganguly, Avishek AU - Basu, Soumya AU - Chakraborty, Paramita AU - Chatterjee, Shilpak AU - Sarkar, Avijit AU - Chatterjee, Mitali AU - Choudhuri, Soumitra Kumar AD - Department of In Vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, Kolkata, India Y1 - 2010/06/22/ PY - 2010 DA - 2010 Jun 22 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - 6 KW - Biotechnology and Bioengineering Abstracts KW - Apoptosis KW - Antioxidants KW - Heavy metals KW - Chemotherapy KW - Drug resistance KW - Lymphatic leukemia KW - Mitochondria KW - Cancer KW - Doxorubicin KW - P-Glycoprotein KW - Cytotoxicity KW - Reactive oxygen species KW - Acetylcysteine KW - Multidrug resistance KW - Acetophenone KW - Chelates KW - Cross-resistance KW - Iron KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745644335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Targeting+Mitochondrial+Cell+Death+Pathway+to+Overcome+Drug+Resistance+with+a+Newly+Developed+Iron+Chelate&rft.au=Ganguly%2C+Avishek%3BBasu%2C+Soumya%3BChakraborty%2C+Paramita%3BChatterjee%2C+Shilpak%3BSarkar%2C+Avijit%3BChatterjee%2C+Mitali%3BChoudhuri%2C+Soumitra+Kumar&rft.aulast=Ganguly&rft.aufirst=Avishek&rft.date=2010-06-22&rft.volume=5&rft.issue=6&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0011253 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Antioxidants; Apoptosis; Heavy metals; Drug resistance; Chemotherapy; Lymphatic leukemia; Mitochondria; Doxorubicin; Cancer; Cytotoxicity; P-Glycoprotein; Reactive oxygen species; Acetylcysteine; Multidrug resistance; Chelates; Acetophenone; Iron; Cross-resistance DO - http://dx.doi.org/10.1371/journal.pone.0011253 ER - TY - CPAPER T1 - Multi-Modal Superparamagnetic Nanoprobe: Harnessing Magnetic, Nuclear, and Optical Power for Diagnostic Imaging Applications T2 - 2010 Symposium on Nano Medical Sciences AN - 839699161; 5927192 JF - 2010 Symposium on Nano Medical Sciences AU - Bumb, A AU - Regino, C AU - Bernardo, M AU - Dobson, P AU - Choyke, P AU - Brechbiel, M Y1 - 2010/06/21/ PY - 2010 DA - 2010 Jun 21 KW - {Q1} KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839699161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Symposium+on+Nano+Medical+Sciences&rft.atitle=Multi-Modal+Superparamagnetic+Nanoprobe%3A+Harnessing+Magnetic%2C+Nuclear%2C+and+Optical+Power+for+Diagnostic+Imaging+Applications&rft.au=Bumb%2C+A%3BRegino%2C+C%3BBernardo%2C+M%3BDobson%2C+P%3BChoyke%2C+P%3BBrechbiel%2C+M&rft.aulast=Bumb&rft.aufirst=A&rft.date=2010-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Symposium+on+Nano+Medical+Sciences&rft.issn=&rft_id=info:doi/ L2 - http://www.techconnectworld.com/Nanotech2010/symposia/Nano_Medicine.ht LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Nanotechnology for Biomedical Imaging, Bioengineering and Regenerative Medicine T2 - 2010 Annual NSTI Conference on Bio Sensors and Diagnostics AN - 839671917; 5922784 JF - 2010 Annual NSTI Conference on Bio Sensors and Diagnostics AU - Hunziker, R Y1 - 2010/06/21/ PY - 2010 DA - 2010 Jun 21 KW - {Q1} KW - Nanotechnology KW - Imaging techniques KW - Regeneration KW - Biotechnology KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839671917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+NSTI+Conference+on+Bio+Sensors+and+Diagnostics&rft.atitle=Nanotechnology+for+Biomedical+Imaging%2C+Bioengineering+and+Regenerative+Medicine&rft.au=Hunziker%2C+R&rft.aulast=Hunziker&rft.aufirst=R&rft.date=2010-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+NSTI+Conference+on+Bio+Sensors+and+Diagnostics&rft.issn=&rft_id=info:doi/ L2 - http://www.techconnectworld.com/Nanotech2010/symposia/Biosensors_Diagn LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Cancer Nanotechnology: Prospect for a New Class of Diagnostic and Therapeutic Solutions T2 - 2010 Annual NSTI Conference on Bio Sensors and Diagnostics AN - 839671866; 5922782 JF - 2010 Annual NSTI Conference on Bio Sensors and Diagnostics AU - Nagahara, L Y1 - 2010/06/21/ PY - 2010 DA - 2010 Jun 21 KW - {Q1} KW - Cancer KW - New classes KW - Nanotechnology KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839671866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+NSTI+Conference+on+Bio+Sensors+and+Diagnostics&rft.atitle=Cancer+Nanotechnology%3A+Prospect+for+a+New+Class+of+Diagnostic+and+Therapeutic+Solutions&rft.au=Nagahara%2C+L&rft.aulast=Nagahara&rft.aufirst=L&rft.date=2010-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+NSTI+Conference+on+Bio+Sensors+and+Diagnostics&rft.issn=&rft_id=info:doi/ L2 - http://www.techconnectworld.com/Nanotech2010/symposia/Biosensors_Diagn LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Nanotechnology for the Diagnosis and Treatment of Heart, Lung, and Blood Diseases T2 - 2010 Annual NSTI Conference on Bio Sensors and Diagnostics AN - 839671353; 5922783 JF - 2010 Annual NSTI Conference on Bio Sensors and Diagnostics AU - Buxton, D Y1 - 2010/06/21/ PY - 2010 DA - 2010 Jun 21 KW - {Q1} KW - Lung diseases KW - Nanotechnology KW - Blood KW - Haematological diseases KW - Heart KW - Disease control KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839671353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+NSTI+Conference+on+Bio+Sensors+and+Diagnostics&rft.atitle=Nanotechnology+for+the+Diagnosis+and+Treatment+of+Heart%2C+Lung%2C+and+Blood+Diseases&rft.au=Buxton%2C+D&rft.aulast=Buxton&rft.aufirst=D&rft.date=2010-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+NSTI+Conference+on+Bio+Sensors+and+Diagnostics&rft.issn=&rft_id=info:doi/ L2 - http://www.techconnectworld.com/Nanotech2010/symposia/Biosensors_Diagn LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - The Collaboratory for Structural Nanobiology T2 - 2010 Symposium on Nano for Biotech, Interfaces & Tissues AN - 839661442; 5927006 JF - 2010 Symposium on Nano for Biotech, Interfaces & Tissues AU - Cachau, R AU - Gonzalez-Ibanez, A AU - Sandoval, C AU - Gonzalez-Nilo, F Y1 - 2010/06/21/ PY - 2010 DA - 2010 Jun 21 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839661442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Symposium+on+Nano+for+Biotech%2C+Interfaces+%26+Tissues&rft.atitle=The+Collaboratory+for+Structural+Nanobiology&rft.au=Cachau%2C+R%3BGonzalez-Ibanez%2C+A%3BSandoval%2C+C%3BGonzalez-Nilo%2C+F&rft.aulast=Cachau&rft.aufirst=R&rft.date=2010-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Symposium+on+Nano+for+Biotech%2C+Interfaces+%26+Tissues&rft.issn=&rft_id=info:doi/ L2 - http://www.techconnectworld.com/Nanotech2010/symposia/nano_bio_technol LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Influence of Mechano- and Magnetochemically Synthesized Magnetosensitive Nanocomplex and Spatially Inhomogeneous Electromagnetic Irradiation on Transplanted Animal Tumor T2 - 2010 Symposium on Nanotechnology for Cancer Prevention, Diagnosis and Treatment (CancerNano 2010) AN - 839655093; 5911875 JF - 2010 Symposium on Nanotechnology for Cancer Prevention, Diagnosis and Treatment (CancerNano 2010) AU - Orel, V AU - Shevchenko, A AU - Romanov, A AU - Dzyatkovska, I AU - Nikolov, M AU - Mel'nik, Yu AU - Dzyatkovska, N AU - Shchepotin, I AU - Uvarov, V Y1 - 2010/06/20/ PY - 2010 DA - 2010 Jun 20 KW - {Q1} KW - Tumors KW - Irradiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839655093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Symposium+on+Nanotechnology+for+Cancer+Prevention%2C+Diagnosis+and+Treatment+%28CancerNano+2010%29&rft.atitle=Influence+of+Mechano-+and+Magnetochemically+Synthesized+Magnetosensitive+Nanocomplex+and+Spatially+Inhomogeneous+Electromagnetic+Irradiation+on+Transplanted+Animal+Tumor&rft.au=Orel%2C+V%3BShevchenko%2C+A%3BRomanov%2C+A%3BDzyatkovska%2C+I%3BNikolov%2C+M%3BMel%27nik%2C+Yu%3BDzyatkovska%2C+N%3BShchepotin%2C+I%3BUvarov%2C+V&rft.aulast=Orel&rft.aufirst=V&rft.date=2010-06-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Symposium+on+Nanotechnology+for+Cancer+Prevention%2C+Diagnosis+and+Treatment+%28CancerNano+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.techconnectworld.com/Nanotech2010/symposia/Cancer.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Drugs Interfering with Endocannabinoids: Is There a Future? T2 - 78th Congress of the European Atherosclerosis Society (EAS 2010) AN - 839654581; 5899639 JF - 78th Congress of the European Atherosclerosis Society (EAS 2010) AU - Kunos, George Y1 - 2010/06/20/ PY - 2010 DA - 2010 Jun 20 KW - {Q1} KW - Drugs KW - Cannabinoids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839654581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=78th+Congress+of+the+European+Atherosclerosis+Society+%28EAS+2010%29&rft.atitle=Drugs+Interfering+with+Endocannabinoids%3A+Is+There+a+Future%3F&rft.au=Kunos%2C+George&rft.aulast=Kunos&rft.aufirst=George&rft.date=2010-06-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=78th+Congress+of+the+European+Atherosclerosis+Society+%28EAS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sessionplan.com/eas2010/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Somatic Diversification of Adaptive Immune Receptors in Jawless Vertebrates T2 - 7th International Conference on Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB-2010) AN - 839649694; 5913051 JF - 7th International Conference on Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB-2010) AU - Rogozin, Igor Y1 - 2010/06/20/ PY - 2010 DA - 2010 Jun 20 KW - {Q1} KW - Receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839649694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+International+Conference+on+Bioinformatics+of+Genome+Regulation+and+Structure%5CSystems+Biology+%28BGRS%5CSB-2010%29&rft.atitle=Somatic+Diversification+of+Adaptive+Immune+Receptors+in+Jawless+Vertebrates&rft.au=Rogozin%2C+Igor&rft.aulast=Rogozin&rft.aufirst=Igor&rft.date=2010-06-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+International+Conference+on+Bioinformatics+of+Genome+Regulation+and+Structure%5CSystems+Biology+%28BGRS%5CSB-2010%29&rft.issn=&rft_id=info:doi/ L2 - http://conf.nsc.ru/files/conferences/BGRSSB2010/24756/Conference%20pro LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Its All in the Neck: How the Escrts Make Multivesicular Bodies T2 - 2010 Gordon Research Conference on Lysosomes & Endocytosis AN - 839606508; 5877978 JF - 2010 Gordon Research Conference on Lysosomes & Endocytosis AU - Hurley, Jim Y1 - 2010/06/20/ PY - 2010 DA - 2010 Jun 20 KW - {Q1} KW - Neck KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839606508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Lysosomes+%26+Endocytosis&rft.atitle=Its+All+in+the+Neck%3A+How+the+Escrts+Make+Multivesicular+Bodies&rft.au=Hurley%2C+Jim&rft.aulast=Hurley&rft.aufirst=Jim&rft.date=2010-06-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Lysosomes+%26+Endocytosis&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=lysosomes LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Progress and challenges in 3D compositional mapping of eukaryotic cells T2 - 2010 Gordon Research Conference on Three Dimensional Electron Microscopy AN - 839605478; 5878077 JF - 2010 Gordon Research Conference on Three Dimensional Electron Microscopy AU - Subramaniam, Sriram Y1 - 2010/06/20/ PY - 2010 DA - 2010 Jun 20 KW - {Q1} KW - Mapping KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839605478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Three+Dimensional+Electron+Microscopy&rft.atitle=Progress+and+challenges+in+3D+compositional+mapping+of+eukaryotic+cells&rft.au=Subramaniam%2C+Sriram&rft.aulast=Subramaniam&rft.aufirst=Sriram&rft.date=2010-06-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Three+Dimensional+Electron+Microscopy&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=threedim LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Autophagosome Biogenesis During Starvation T2 - 2010 Gordon Research Conference on Lysosomes & Endocytosis AN - 839604680; 5878010 JF - 2010 Gordon Research Conference on Lysosomes & Endocytosis AU - Lippincott-Schwartz, Jennifer Y1 - 2010/06/20/ PY - 2010 DA - 2010 Jun 20 KW - {Q1} KW - Phagosomes KW - Starvation KW - Biogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839604680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Lysosomes+%26+Endocytosis&rft.atitle=Autophagosome+Biogenesis+During+Starvation&rft.au=Lippincott-Schwartz%2C+Jennifer&rft.aulast=Lippincott-Schwartz&rft.aufirst=Jennifer&rft.date=2010-06-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Lysosomes+%26+Endocytosis&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=lysosomes LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Neurofilament proteins (NF-M/H) are aberrantly and hyperphosphorylated in Alzheimer Disease: Quantitative phosphoproteomics by iTRAQ T2 - 2010 Gordon Research Conference on Intermediate Filaments AN - 839601008; 5877720 JF - 2010 Gordon Research Conference on Intermediate Filaments AU - Rudrabhatla, Parvathi Y1 - 2010/06/20/ PY - 2010 DA - 2010 Jun 20 KW - {Q1} KW - Alzheimer's disease KW - Neurodegenerative diseases KW - Neurofilament protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839601008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Intermediate+Filaments&rft.atitle=Neurofilament+proteins+%28NF-M%2FH%29+are+aberrantly+and+hyperphosphorylated+in+Alzheimer+Disease%3A+Quantitative+phosphoproteomics+by+iTRAQ&rft.au=Rudrabhatla%2C+Parvathi&rft.aulast=Rudrabhatla&rft.aufirst=Parvathi&rft.date=2010-06-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Intermediate+Filaments&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=intermed LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Signaling to ABC Transporters at the Blood-Brain Barrier: The Good News and the Bad T2 - 2010 Gordon Research Conference on Barriers Of The CNS AN - 839600531; 5877441 JF - 2010 Gordon Research Conference on Barriers Of The CNS AU - Miller, David Y1 - 2010/06/20/ PY - 2010 DA - 2010 Jun 20 KW - {Q1} KW - ABC transporter KW - Blood-brain barrier KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839600531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Barriers+Of+The+CNS&rft.atitle=Signaling+to+ABC+Transporters+at+the+Blood-Brain+Barrier%3A+The+Good+News+and+the+Bad&rft.au=Miller%2C+David&rft.aulast=Miller&rft.aufirst=David&rft.date=2010-06-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Barriers+Of+The+CNS&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=cns LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Sphingosine-1-Phosphate (S1P) exposure reduces P-glycoprotein (P-gp) transport activity in rat brain capillaries T2 - 2010 Gordon-Kenan Research Seminar Barriers Of The CNS AN - 839603255; 5877493 JF - 2010 Gordon-Kenan Research Seminar Barriers Of The CNS AU - Peart, John Y1 - 2010/06/19/ PY - 2010 DA - 2010 Jun 19 KW - {Q1} KW - Brain KW - P-Glycoprotein KW - Sphingosine 1-phosphate KW - Capillaries KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839603255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon-Kenan+Research+Seminar+Barriers+Of+The+CNS&rft.atitle=Sphingosine-1-Phosphate+%28S1P%29+exposure+reduces+P-glycoprotein+%28P-gp%29+transport+activity+in+rat+brain+capillaries&rft.au=Peart%2C+John&rft.aulast=Peart&rft.aufirst=John&rft.date=2010-06-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon-Kenan+Research+Seminar+Barriers+Of+The+CNS&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=grs_cns LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - JOUR T1 - Traditional risk factors and D-dimer predict incident cardiovascular disease events in chronic HIV infection AN - 746310395; 13195973 AB - Objective: Cardiovascular disease (CVD) contributes significantly to HIV-related morbidity and mortality. Chronic immune activation and inflammation are thought to augment the progression of atherosclerotic disease. In this retrospective, case-control study of HIV-infected individuals, we investigated the association of traditional cardiac risk factors, HIV-related disease, and inflammation with CVD events. Methods: HIV-infected individuals who experienced an incident CVD event while enrolled in National Institutes of Health clinical protocols from 1995 to 2009 were matched 2:1 to HIV-infected individuals without known CVD. Markers of inflammation and cell activation were measured in serum or plasma using ELISA-based assays and peripheral mononuclear cells by four-color flow cytometry. Results: Fifty-two patients experienced an incident CVD event. Events were related to smoking, dyslipidemia, hyperglycemia, and family history as well as elevated D-dimer, soluble vascular cell adhesion molecule-1, tissue inhibitor of metalloproteinase-1, and soluble tissue factor, but not high-sensitivity C-reactive protein. No significant differences in antiviral therapy, CD4 super(+) T-cell count, or CD38 and human leukocyte antigen-DR expression were identified between patients and controls. In multivariable analysis, smoking, family history, D-dimer, and glucose were independently related to CVD risk. Conclusion: In this cohort, CVD risk was related to traditional CVD risk factors and markers of thrombosis and endothelial damage, but not to high-sensitivity C-reactive protein or markers of T-cell activation such as CD38/human leukocyte antigen-DR coexpression. D-dimer may help identify HIV-infected patients at elevated CVD risk. JF - AIDS AU - Ford, E S AU - Greenwald, J H AU - Richterman, A G AU - Rupert, A AU - Dutcher, L AU - Badralmaa, Y AU - Ven Natarajan, AU - Rehm, C AU - Hadigan, C AU - Sereti, I AD - National Institutes of Health, 10 Center Drive, Building 10, Room 11B07A, Bethesda, MD 20892, USA, isereti@niaid.nih.gov Y1 - 2010/06/19/ PY - 2010 DA - 2010 Jun 19 SP - 1509 EP - 1517 VL - 24 IS - 10 SN - 0269-9370, 0269-9370 KW - Toxicology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Risk Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - Acquired immune deficiency syndrome KW - Glucose KW - CD38 antigen KW - Arteriosclerosis KW - Morbidity KW - Cell activation KW - Flow cytometry KW - Genetics KW - Smoking KW - CD4 antigen KW - Hyperglycemia KW - Risk factors KW - Lymphocytes T KW - Leukocytes (mononuclear) KW - Mortality KW - thromboembolism KW - Tissue factor KW - Thrombosis KW - Inflammation KW - Tissue inhibitor of metalloproteinase 1 KW - vascular cell adhesion molecule 1 KW - Human immunodeficiency virus KW - Dyslipidemia KW - Chronic infection KW - Proteins KW - Cardiovascular diseases KW - Immune response KW - C-reactive protein KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - X 24380:Social Poisons & Drug Abuse KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746310395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Traditional+risk+factors+and+D-dimer+predict+incident+cardiovascular+disease+events+in+chronic+HIV+infection&rft.au=Ford%2C+E+S%3BGreenwald%2C+J+H%3BRichterman%2C+A+G%3BRupert%2C+A%3BDutcher%2C+L%3BBadralmaa%2C+Y%3BVen+Natarajan%2C%3BRehm%2C+C%3BHadigan%2C+C%3BSereti%2C+I&rft.aulast=Ford&rft.aufirst=E&rft.date=2010-06-19&rft.volume=24&rft.issue=10&rft.spage=1509&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0b013e32833ad914 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Mortality; Leukocytes (mononuclear); Tissue factor; Glucose; CD38 antigen; Arteriosclerosis; Thrombosis; Morbidity; Inflammation; Cell activation; Tissue inhibitor of metalloproteinase 1; Flow cytometry; vascular cell adhesion molecule 1; Smoking; CD4 antigen; Hyperglycemia; Risk factors; Chronic infection; Dyslipidemia; Lymphocytes T; Immune response; Cardiovascular diseases; C-reactive protein; Genetics; Acquired immune deficiency syndrome; thromboembolism; Human immunodeficiency virus; Proteins DO - http://dx.doi.org/10.1097/QAD.0b013e32833ad914 ER - TY - JOUR T1 - New World Hantaviruses Activate IFNl Production in Type I IFN-Deficient Vero E6 Cells AN - 746164641; 13167105 AB - Hantaviruses indigenous to the New World are the etiologic agents of hantavirus cardiopulmonary syndrome (HCPS). These viruses induce a strong interferon-stimulated gene (ISG) response in human endothelial cells. African green monkey-derived Vero E6 cells are used to propagate hantaviruses as well as many other viruses. The utility of the Vero E6 cell line for virus production is thought to owe to their lack of genes encoding type I interferons (IFN), rendering them unable to mount an efficient innate immune response to virus infection. Interferon l, a more recently characterized type III IFN, is transcriptionally controlled much like the type I IFNs, and activates the innate immune system in a similar manner. We show that Vero E6 cells respond to hantavirus infection by secreting abundant IFNl. Three New World hantaviruses were similarly able to induce IFNl expression in this cell line. The IFNl contained within virus preparations generated with Vero E6 cells independently activates ISGs when used to infect several non-endothelial cell lines, whereas innate immune responses by endothelial cells are specifically due to viral infection. We show further that Sin Nombre virus replicates to high titer in human hepatoma cells (Huh7) without inducing ISGs. Herein we report that Vero E6 cells respond to viral infection with a highly active antiviral response, including secretion of abundant IFNl. This cytokine is biologically active, and when contained within viral preparations and presented to human epithelioid cell lines, results in the robust activation of innate immune responses. We also show that both Huh7 and A549 cell lines do not respond to hantavirus infection, confirming that the cytoplasmic RNA helicase pathways possessed by these cells are not involved in hantavirus recognition. We demonstrate that Vero E6 actively respond to virus infection and inhibiting IFNl production in these cells might increase their utility for virus propagation. JF - PLoS ONE AU - Prescott, Joseph AU - Hall, Pamela AU - Acuna-Retamar, Mariana AU - Ye, Chunyan AU - Wathelet, Marc G AU - Ebihara, Hideki AU - Feldmann, Heinz AU - Hjelle, Brian AD - Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America Y1 - 2010/06/17/ PY - 2010 DA - 2010 Jun 17 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - 6 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Immunology Abstracts KW - Cytokines KW - Endothelial cells KW - Hepatoma KW - Immune response KW - Infection KW - Interferon KW - RNA helicase KW - Transcription KW - a-Interferon KW - Sin Nombre virus KW - Hantavirus KW - A 01340:Antibiotics & Antimicrobials KW - V 22350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746164641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Affective+Disorders&rft.atitle=Effectiveness+and+acceptability+of+accelerated+repetitive+transcranial+magnetic+stimulation+%28rTMS%29+for+treatment-resistant+major+depressive+disorder%3A+An+open+label+trial&rft.au=McGirr%2C+Alexander%3BVan+den+Eynde%2C+Frederique%3BTovar-Perdomo%2C+Santiago%3BFleck%2C+Marcelo+P.A.%3BBerlim%2C+Marcelo+T.&rft.aulast=McGirr&rft.aufirst=Alexander&rft.date=2015-01-01&rft.volume=173&rft.issue=&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=Journal+of+Affective+Disorders&rft.issn=01650327&rft_id=info:doi/10.1016%2Fj.jad.2014.10.068 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - RNA helicase; Endothelial cells; Hepatoma; Interferon; Transcription; Cytokines; Immune response; Infection; a-Interferon; Sin Nombre virus; Hantavirus DO - http://dx.doi.org/10.1371/journal.pone.0011159 ER - TY - JOUR T1 - The Anopheles gambiae Oxidation Resistance 1 (OXR1) Gene Regulates Expression of Enzymes That Detoxify Reactive Oxygen Species AN - 746011693; 13167100 AB - OXR1 is an ancient gene, present in all eukaryotes examined so far that confers protection from oxidative stress by an unknown mechanism. The most highly conserved region of the gene is the carboxyl-terminal TLDc domain, which has been shown to be sufficient to prevent oxidative damage. OXR1 has a complex genomic structure in the mosquito A. gambiae, and we confirm that multiple splice forms are expressed in adult females. Our studies revealed that OXR1 regulates the basal levels of catalase (CAT) and glutathione peroxidase (Gpx) expression, two enzymes involved in detoxification of hydrogen peroxide, giving new insight into the mechanism of action of OXR1. Gene silencing experiments indicate that the Jun Kinase (JNK) gene acts upstream of OXR1 and also regulates expression of CAT and GPx. Both OXR1 and JNK genes are required for adult female mosquitoes to survive chronic oxidative stress. OXR1 silencing decreases P. berghei oocyst formation. Unexpectedly, JNK silencing has the opposite effect and enhances Plasmodium infection in the mosquito, suggesting that JNK may also mediate some, yet to be defined, antiparasitic response. The JNK pathway regulates OXR1 expression and OXR1, in turn, regulates expression of enzymes that detoxify reactive oxygen species (ROS) in Anopheles gambiae. OXR1 silencing decreases Plasmodium infection in the mosquito, while JNK silencing has the opposite effect and enhances infection. JF - PLoS ONE AU - Jaramillo-Gutierrez, Giovanna AU - Molina-Cruz, Alvaro AU - Kumar, Sanjeev AU - Barillas-Mury, Carolina AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America Y1 - 2010/06/17/ PY - 2010 DA - 2010 Jun 17 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - 6 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Biochemistry Abstracts 2: Nucleic Acids; Entomology Abstracts KW - Detoxification KW - c-Jun amino-terminal kinase KW - Oocysts KW - Enzymes KW - Pest control KW - Anopheles gambiae KW - Catalase KW - Gene expression KW - Plasmodium KW - Reactive oxygen species KW - Oxidative stress KW - Glutathione peroxidase KW - Hydrogen peroxide KW - Oxidation KW - Coenzymes KW - genomics KW - Aquatic insects KW - Gene silencing KW - Q1 08484:Species interactions: parasites and diseases KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - N 14845:Miscellaneous KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746011693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=The+Anopheles+gambiae+Oxidation+Resistance+1+%28OXR1%29+Gene+Regulates+Expression+of+Enzymes+That+Detoxify+Reactive+Oxygen+Species&rft.au=Jaramillo-Gutierrez%2C+Giovanna%3BMolina-Cruz%2C+Alvaro%3BKumar%2C+Sanjeev%3BBarillas-Mury%2C+Carolina&rft.aulast=Jaramillo-Gutierrez&rft.aufirst=Giovanna&rft.date=2010-06-17&rft.volume=5&rft.issue=6&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0011168 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Detoxification; Gene expression; Oxidation; Enzymes; Coenzymes; Pest control; Aquatic insects; c-Jun amino-terminal kinase; Oocysts; Reactive oxygen species; Hydrogen peroxide; Glutathione peroxidase; Oxidative stress; genomics; Catalase; Gene silencing; Plasmodium; Anopheles gambiae DO - http://dx.doi.org/10.1371/journal.pone.0011168 ER - TY - JOUR T1 - Mutagenicity of N-ethyl-N-nitrosourea, N-methyl-N-nitrosourea, methyl methanesulfonate and ethyl methanesulfonate in the developing Syrian hamster fetus. AN - 734026877; 20363361 AB - N-ethyl-N-nitrosourea (ENU) and N-methyl-N-nitrosourea (MNU) are well-known direct-acting transplacental mutagens and carcinogens. Methyl methanesulfonate (MMS) and ethyl methanesulfonate (EMS) are also direct-acting but more stable compounds and form a different proportion of the various methyl and ethyl DNA adducts. The transplacental mutagenicity and carcinogenicity of MMS and EMS have not been well characterized. We tested the mutagenicity to the developing Syrian hamster by these compounds under identical conditions and with a range of dose. Mutant fetal cells were selected for diphtheria toxin resistance. All four compounds were significantly mutagenic. MNU was the most active and MMS the least active of the compounds. ENU and MNU demonstrated linear dose-response curves, whereas that for EMS seemed to be supralinear over the range 0.125-0.5 mmol/kg. At its highest dose, EMS was comparable to ENU in mutagenicity. In view of a recent accidental exposure of pregnant women and others to EMS, further studies of this compound in animal models may be warranted. Published by Elsevier B.V. JF - Mutation research AU - Donovan, Paul AU - Smith, George AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA. donovanp@mail.nih.gov Y1 - 2010/06/17/ PY - 2010 DA - 2010 Jun 17 SP - 55 EP - 57 VL - 699 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Mutagens KW - 0 KW - Methylnitrosourea KW - 684-93-5 KW - Ethyl Methanesulfonate KW - 9H154DI0UP KW - Methyl Methanesulfonate KW - AT5C31J09G KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - Animals KW - Mutagenicity Tests KW - Pregnancy, Animal KW - Mesocricetus -- embryology KW - Female KW - Pregnancy KW - Cricetinae KW - Maternal-Fetal Exchange KW - Methyl Methanesulfonate -- toxicity KW - Fetus -- drug effects KW - Ethylnitrosourea -- toxicity KW - Methylnitrosourea -- toxicity KW - Ethyl Methanesulfonate -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734026877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Mutagenicity+of+N-ethyl-N-nitrosourea%2C+N-methyl-N-nitrosourea%2C+methyl+methanesulfonate+and+ethyl+methanesulfonate+in+the+developing+Syrian+hamster+fetus.&rft.au=Donovan%2C+Paul%3BSmith%2C+George&rft.aulast=Donovan&rft.aufirst=Paul&rft.date=2010-06-17&rft.volume=699&rft.issue=1-2&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/10.1016%2Fj.mrgentox.2010.03.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-20 N1 - Date created - 2010-05-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mrgentox.2010.03.012 ER - TY - CPAPER T1 - Molecular tools: uses and promise for studying brain circuits underlying higher function T2 - 2010 AREADNE Conference: Research in Encoding and Decoding of Neural Ensembles (AREADNE 2010) AN - 1312927240; 6031844 JF - 2010 AREADNE Conference: Research in Encoding and Decoding of Neural Ensembles (AREADNE 2010) AU - Richmond, Barry Y1 - 2010/06/17/ PY - 2010 DA - 2010 Jun 17 KW - Brain KW - Circuits KW - Tool use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312927240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AREADNE+Conference%3A+Research+in+Encoding+and+Decoding+of+Neural+Ensembles+%28AREADNE+2010%29&rft.atitle=Molecular+tools%3A+uses+and+promise+for+studying+brain+circuits+underlying+higher+function&rft.au=Richmond%2C+Barry&rft.aulast=Richmond&rft.aufirst=Barry&rft.date=2010-06-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AREADNE+Conference%3A+Research+in+Encoding+and+Decoding+of+Neural+Ensembles+%28AREADNE+2010%29&rft.issn=00930415&rft_id=info:doi/ L2 - http://www.areadne.org/2010/hatsopoulos-pezaris-2010-areadne.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Pediatric Phase I Trial Design Using Maximum Target Inhibition as the Primary Endpoint AN - 745643949; 13150681 AB - The extent to which a drug inhibits a target responsible for a therapeutic effect is a more rational primary endpoint for dose-finding studies of more selective anticancer drugs than the conventional endpoint of dose-limiting toxicity (DLT) used for cytotoxic agents. An adaptive phase I trial design incorporating maximum target inhibition as the primary endpoint was developed to define the optimal dose of talabostat, a dipeptidyl peptidase (DPP) inhibitor, in children with relapsed or refractory solid tumors. The relationship between dose and effect (percent inhibition of serum DPP-4) was assessed using a maximum effect model. Maximum target inhibition was defined as greater than 90% DPP-4 inhibition in five or more of six patients 24 hours post-dose. If DLT was to occur, the trial would adapt to a traditional phase I design with a more conservative dose escalation. At the 600 kg/m super(2) dose level, serum DPP-4 inhibition at 24 hours was 85%. No talabostat-related DLT occurred. The maximum effect model predicted that 1200 kg/m super(2) of talabostat would maximally inhibit DPP-4. This adaptive trial design appears to be feasible, safe, and efficient and warrants further evaluation for development of molecularly targeted agents. JF - Journal of the National Cancer Institute AU - Meany, Holly AU - Balis, Frank M AU - Aikin, Alberta AU - Whitcomb, Patricia AU - Murphy, Robert F AU - Steinberg, Seth M AU - Widemann, Brigitte C AU - Fox, Elizabeth AD - Affiliations of authors: Pharmacology and Experimental Therapeutics Section, Pediatric Oncology Branch (HM, AA, PW, RFM, BCW, EF) and Biostatistics and Data Management Section (SMS), National Cancer Institute, Bethesda, MD; Department of Hematology/Oncology, Children's National Medical Center, Washington, DC (HM); The Children's Hospital of Philadelphia, Philadelphia, PA (FMB, EF), hmeany@cnmc.org Y1 - 2010/06/16/ PY - 2010 DA - 2010 Jun 16 SP - 909 EP - 912 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 12 SN - 0027-8874, 0027-8874 KW - Toxicology Abstracts KW - Pediatrics KW - Solid tumors KW - Cytotoxic agents KW - Toxicity KW - Children KW - Clinical trials KW - peptidase KW - Antitumor agents KW - Models KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745643949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Pediatric+Phase+I+Trial+Design+Using+Maximum+Target+Inhibition+as+the+Primary+Endpoint&rft.au=Meany%2C+Holly%3BBalis%2C+Frank+M%3BAikin%2C+Alberta%3BWhitcomb%2C+Patricia%3BMurphy%2C+Robert+F%3BSteinberg%2C+Seth+M%3BWidemann%2C+Brigitte+C%3BFox%2C+Elizabeth&rft.aulast=Meany&rft.aufirst=Holly&rft.date=2010-06-16&rft.volume=102&rft.issue=12&rft.spage=909&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjq174 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Solid tumors; Pediatrics; Cytotoxic agents; Toxicity; Children; Antitumor agents; peptidase; Clinical trials; Models DO - http://dx.doi.org/10.1093/jnci/djq174 ER - TY - JOUR T1 - Immune Recovery after Autologous Stem Cell Transplantation Is Not Different for HIV-Infected versus HIV-Uninfected Patients with Relapsed or Refractory Lymphoma AN - 754543906; 13267482 AB - Background. High-dose chemotherapy (HDC) and autologous stem cell transplantation (ASCT) are feasible and effective salvage treatments for human immunodeficiency virus (HIV)-related relapse or refractory lymphoma. Among the main concerns with ASCT in HIV-infected persons is the additional immune depletion caused by treatment, which could amplify the preexisting immune deficit. The aims of our study were to assess the impact of conventional chemotherapy before salvage treatment was administered, in this population, and to evaluate immune reconstitution dynamics during ASCT. Methods. All 33 HIV-infected and HIV-uninfected patients who underwent comparable ASCT protocols at the National Cancer Institute (Aviano, Italy) who underwent .1 month of follow-up after transplantation were included in a prospective immunological study. Demographic, clinical, and immunovirological data were obtained before administration of induction therapy, during transplantation, and at 24 months of follow-up. Results. Before HDC, no significant differences were observed in CD4 super(+) cell subsets and signal joint T cell receptor excision circles (sjTRECs), although HIV-infected persons had inverted ratios of CD4 super(+) cells to CD8 super(+) cells because they had higher CD8 super(+) T cell counts, compared with HIV-uninfected persons. After ASCT, this inversion was also observed in HIV-uninfected patients up to 24 months. CD4 super(+) cell subsets had similar recoveries, with a temporary setback in HIV-infected persons 3 months after reinfusion, together with an increase in infections. sjTRECs demonstrated similar dynamics in both populations and serve as a useful predictive marker of recovery of CD4 super(+) cell subsets. No significant changes emerged in HIV DNA levels during the follow-up period, with values at 24 months significantly lower than those at baseline. JF - Clinical Infectious Diseases AU - Simonelli, C AU - Zanussi, S AU - Pratesi, C AU - Rupolo, M AU - Talamini, R AU - Caffau, C AU - Bortolin, M T AU - Tedeschi, R AU - Basaglia, G AU - Mazzucato, M AU - Manuele, R AU - Vaccher, E AU - Spina, M AU - Tirelli, U AD - Microbiology, Immunology and Virology, National Cancer Institute, IRCCS, F. Gallini 2, 33081 Aviano (PN), Italy, szanussi@cro.it Y1 - 2010/06/15/ PY - 2010 DA - 2010 Jun 15 SP - 1672 EP - 1679 VL - 50 IS - 12 SN - 1058-4838, 1058-4838 KW - Immunology Abstracts; Health & Safety Science Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - demography KW - T-cell receptor KW - Chemotherapy KW - Infection KW - Italy KW - Demography KW - Immune reconstitution KW - CD4 antigen KW - infection KW - Lymphocytes T KW - Lymphoma KW - Autografts KW - Data processing KW - stem cell transplantation KW - CD8 antigen KW - chemotherapy KW - Cancer KW - Joints KW - stem cells KW - Human immunodeficiency virus KW - Inversion KW - DNA KW - lymphoma KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22360:AIDS and HIV KW - W 30940:Products KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754543906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Immune+Recovery+after+Autologous+Stem+Cell+Transplantation+Is+Not+Different+for+HIV-Infected+versus+HIV-Uninfected+Patients+with+Relapsed+or+Refractory+Lymphoma&rft.au=Simonelli%2C+C%3BZanussi%2C+S%3BPratesi%2C+C%3BRupolo%2C+M%3BTalamini%2C+R%3BCaffau%2C+C%3BBortolin%2C+M+T%3BTedeschi%2C+R%3BBasaglia%2C+G%3BMazzucato%2C+M%3BManuele%2C+R%3BVaccher%2C+E%3BSpina%2C+M%3BTirelli%2C+U&rft.aulast=Simonelli&rft.aufirst=C&rft.date=2010-06-15&rft.volume=50&rft.issue=12&rft.spage=1672&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/10.1086%2F652866 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Autografts; T-cell receptor; Data processing; stem cell transplantation; Chemotherapy; CD8 antigen; Infection; Joints; Immune reconstitution; Demography; CD4 antigen; Inversion; Lymphocytes T; DNA; Lymphoma; demography; Human immunodeficiency virus; stem cells; infection; lymphoma; Cancer; chemotherapy; Italy DO - http://dx.doi.org/10.1086/652866 ER - TY - JOUR T1 - UMA and MABP domains throw light on receptor endocytosis and selection of endosomal cargoes AN - 746308894; 13114569 AB - Interactions of the ESCRT complexes are critical for endosomal trafficking. We identify two domains with potential significance for this process. The MABP domain present in metazoan ESCRT-I/MVB12 subunits, Crag, a regulator of protein sorting, and bacterial pore-forming proteins might mediate novel membrane interactions in trafficking. The UBAP1-MVB12-[underlin e]associated UMA domain found in MVB12 and UBAP1 defines a novel adaptor that might recruit diverse targets to ESCRT-I. Supplementary information: Supplementary data are available at ftp://ftp.ncbi.nih.gov/pub/aravind/UMA/MVB12.html. JF - Bioinformatics AU - de Souza, Robson F AU - Aravind, L AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA Y1 - 2010/06/15/ PY - 2010 DA - 2010 Jun 15 SP - 1477 EP - 1480 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 26 IS - 12 SN - 1367-4803, 1367-4803 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Protein transport KW - Endocytosis KW - adaptor proteins KW - Data processing KW - membrane trafficking KW - Bioinformatics KW - Metazoa KW - pore-forming proteins KW - J 02330:Biochemistry KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746308894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=UMA+and+MABP+domains+throw+light+on+receptor+endocytosis+and+selection+of+endosomal+cargoes&rft.au=de+Souza%2C+Robson+F%3BAravind%2C+L&rft.aulast=de+Souza&rft.aufirst=Robson&rft.date=2010-06-15&rft.volume=26&rft.issue=12&rft.spage=1477&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtq235 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Endocytosis; Protein transport; adaptor proteins; Data processing; membrane trafficking; Bioinformatics; pore-forming proteins; Metazoa DO - http://dx.doi.org/10.1093/bioinformatics/btq235 ER - TY - JOUR T1 - A low-polynomial algorithm for assembling clusters of orthologous groups from intergenomic symmetric best matches AN - 746306172; 13114580 AB - Motivation: Identifying orthologous genes in multiple genomes is a fundamental task in comparative genomics. Construction of intergenomic symmetrical best matches (SymBets) and joining them into clusters is a popular method of ortholog definition, embodied in several software programs. Despite their wide use, the computational complexity of these programs has not been thoroughly examined.Results: In this work, we show that in the standard approach of iteration through all triangles of SymBets, the memory scales with at least the number of these triangles, O(g super(3)) (where g = number of genomes), and construction time scales with the iteration through each pair, i.e. O(g super(6)). We propose the EdgeSearch algorithm that iterates over edges in the SymBet graph rather than triangles of SymBets, and as a result has a worst-case complexity of only O(g super(3)lo g g). Several optimizations reduce the run-time even further in realistically sparse graphs. In two real-world datasets of genomes from bacteriophages (POGs) and Mollicutes (MOGs), an implementation of the EdgeSearch algorithm runs about an order of magnitude faster than the original algorithm and scales much better with increasing number of genomes, with only minor differences in the final results, and up to 60 times faster than the popular OrthoMCL program with a 90% overlap between the identified groups of orthologs.Availability and implementation: C++ source code freely available for download at ftp.ncbi.nih.gov/pub/wolf/COGs/COGsoft/Contact: dmktowers.orgSupplementary information: Supplementary materials are available at Bioinformatics online. JF - Bioinformatics AU - Kristensen, David M AU - Kannan, Lavanya AU - Coleman, Michael K AU - Wolf, Yuri I AU - Sorokin, Alexander AU - Koonin, Eugene V AU - Mushegian, Arcady AD - super(1) Department of Binformatics, Stowers Institute for Medical Research, Kansas City, MO 64110, super(2) National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894 and super(3) Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, KS 66160, USA Y1 - 2010/06/15/ PY - 2010 DA - 2010 Jun 15 SP - 1481 EP - 1487 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 26 IS - 12 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Mollicutes KW - Phages KW - Computer programs KW - Memory KW - software KW - Algorithms KW - Oligodendrocyte-myelin glycoprotein KW - Bioinformatics KW - genomics KW - Computer applications KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746306172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=A+low-polynomial+algorithm+for+assembling+clusters+of+orthologous+groups+from+intergenomic+symmetric+best+matches&rft.au=Kristensen%2C+David+M%3BKannan%2C+Lavanya%3BColeman%2C+Michael+K%3BWolf%2C+Yuri+I%3BSorokin%2C+Alexander%3BKoonin%2C+Eugene+V%3BMushegian%2C+Arcady&rft.aulast=Kristensen&rft.aufirst=David&rft.date=2010-06-15&rft.volume=26&rft.issue=12&rft.spage=1481&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtq229 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Phages; Computer programs; software; Memory; Algorithms; Oligodendrocyte-myelin glycoprotein; genomics; Bioinformatics; Computer applications; Mollicutes DO - http://dx.doi.org/10.1093/bioinformatics/btq229 ER - TY - JOUR T1 - Prospective study of body mass index, physical activity and thyroid cancer AN - 745719154; 13163634 AB - Increased body size and physical inactivity are positively related to risk of several cancers, but only few epidemiologic studies have investigated body-mass index (BMI) and physical activity in relation to thyroid cancer. We examined the relations of BMI and physical activity to thyroid cancer in a prospective cohort of 484,326 United States men and women, followed from 1995/1996 to 2003. During 3,490,300 person-years of follow-up, we documented 352 newly incident cases of thyroid cancer. The multivariate relative risks (RR) of thyroid cancer for BMI values of 18.5-24.9 (reference), 25.0-29.9 and 30 kg m-2 were 1.0, 1.27 and 1.39 [95% confidence interval (CI) = 1.05-1.85]. Adiposity predicted papillary thyroid cancers (RR comparing extreme BMI categories = 1.47; 95% CI = 1.03-2.10) and, based on small numbers, suggestively predicted follicular thyroid cancers (RR = 1.49; 95% CI = 0.79-2.82) and anaplastic thyroid cancers (RR = 5.80; 95% CI = 0.99-34.19). No relation with BMI was noted for medullary thyroid cancers (RR = 0.97; 95% CI = 0.27-3.43). The positive relation of BMI to total thyroid cancer was evident for men but not for women. However, the test of interaction (p = 0.463) indicated no statistically significant gender difference. Physical activity was unassociated with thyroid cancer. The RRs of total thyroid cancer for low (reference), intermediate, and high level of physical activity were 1.0, 1.01 and 1.01 (95% CI = 0.76-1.34, p for trend = 0.931), respectively. Our results support an adverse effect of adiposity on risk for developing total and papillary, and possibly follicular thyroid cancers. Based on only 15 cases, adiposity was unrelated to medullary thyroid cancers. Physical activity was unrelated to total thyroid cancer. JF - International Journal of Cancer AU - Leitzmann, Michael F AU - Brenner, Alina AU - Moore, Steven C AU - Koebnick, Corinna AU - Park, Yikyung AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Ron, Elaine AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, michael.leitzmann@klinik.uni-regensburg.de Y1 - 2010/06/15/ PY - 2010 DA - 2010 Jun 15 SP - 2947 EP - 2956 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 126 IS - 12 SN - 0020-7136, 0020-7136 KW - Physical Education Index; Risk Abstracts KW - Statistics KW - Men KW - Body mass KW - Women KW - Thyroid KW - body size KW - Exercise KW - Sex differences KW - Cancer KW - Anthropometry KW - USA KW - body mass KW - Gender KW - physical activity KW - Trends KW - Side effects KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745719154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Depression+and+Anxiety&rft.atitle=Patient%E2%80%90reported+outcomes+of+quality+of+life%2C+functioning%2C+and+depressive+symptom+severity+in+major+depressive+disorder+comorbid+with+panic+disorder+before+and+after+SSRI+treatment+in+the+STAR*D+trial&rft.au=IsHak%2C+Waguih+William%3BMirocha%2C+James%3BChristensen%2C+Scott%3BWu%2C+Fan%3BKwock%2C+Richard%3BBehjat%2C+Joseph%3BPi%2C+Sarah%3BAkopyan%2C+Araks%3BPeselow%2C+Eric+D.%3BCohen%2C+Robert+M.%3BElashoff%2C+David&rft.aulast=IsHak&rft.aufirst=Waguih&rft.date=2014-08-01&rft.volume=31&rft.issue=8&rft.spage=707&rft.isbn=&rft.btitle=&rft.title=Depression+and+Anxiety&rft.issn=10914269&rft_id=info:doi/10.1002%2Fda.22152 L2 - http://www3.interscience.wiley.com/journal/122613798/abstract LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Anthropometry; Statistics; Men; Body mass; Women; Exercise; Trends; Sex differences; Cancer; body mass; Gender; Thyroid; body size; physical activity; Side effects; USA DO - http://dx.doi.org/10.1002/ijc.24913 ER - TY - JOUR T1 - Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data. AN - 733169354; 20494999 AB - Odds ratios for head and neck cancer increase with greater cigarette and alcohol use and lower body mass index (BMI; weight (kg)/height(2) (m(2))). Using data from the International Head and Neck Cancer Epidemiology Consortium, the authors conducted a formal analysis of BMI as a modifier of smoking- and alcohol-related effects. Analysis of never and current smokers included 6,333 cases, while analysis of never drinkers and consumers of < or =10 drinks/day included 8,452 cases. There were 8,000 or more controls, depending on the analysis. Odds ratios for all sites increased with lower BMI, greater smoking, and greater drinking. In polytomous regression, odds ratios for BMI (P = 0.65), smoking (P = 0.52), and drinking (P = 0.73) were homogeneous for oral cavity and pharyngeal cancers. Odds ratios for BMI and drinking were greater for oral cavity/pharyngeal cancer (P < 0.01), while smoking odds ratios were greater for laryngeal cancer (P < 0.01). Lower BMI enhanced smoking- and drinking-related odds ratios for oral cavity/pharyngeal cancer (P < 0.01), while BMI did not modify smoking and drinking odds ratios for laryngeal cancer. The increased odds ratios for all sites with low BMI may suggest related carcinogenic mechanisms; however, BMI modification of smoking and drinking odds ratios for cancer of the oral cavity/pharynx but not larynx cancer suggests additional factors specific to oral cavity/pharynx cancer. JF - American journal of epidemiology AU - Lubin, Jay H AU - Gaudet, Mia M AU - Olshan, Andrew F AU - Kelsey, Karl AU - Boffetta, Paolo AU - Brennan, Paul AU - Castellsague, Xavier AU - Chen, Chu AU - Curado, Maria Paula AU - Dal Maso, Luigino AU - Daudt, Alexander W AU - Fabianova, Eleonora AU - Fernandez, Leticia AU - Wünsch-Filho, Victor AU - Franceschi, Silvia AU - Herrero, Rolando AU - Koifman, Sergio AU - La Vecchia, Carlo AU - Lazarus, Philip AU - Levi, Fabio AU - Lissowska, Jolanta AU - Mates, Ioan Nicolae AU - Matos, Elena AU - McClean, Michael AU - Menezes, Ana AU - Morgenstern, Hal AU - Muscat, Joshua AU - Eluf Neto, Jose AU - Purdue, Mark P AU - Rudnai, Peter AU - Schwartz, Stephen M AU - Shangina, Oxana AU - Sturgis, Erich M AU - Szeszenia-Dabrowska, Neonilia AU - Talamini, Renato AU - Wei, Qingyi AU - Winn, Deborah AU - Zhang, Zuo-Feng AU - Hashibe, Mia AU - Hayes, Richard B AD - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Rockville, MD 20852, USA. lubinj@mail.nih.gov Y1 - 2010/06/15/ PY - 2010 DA - 2010 Jun 15 SP - 1250 EP - 1261 VL - 171 IS - 12 KW - Index Medicus KW - Odds Ratio KW - Risk Factors KW - Humans KW - Case-Control Studies KW - Pharyngeal Neoplasms -- etiology KW - Mouth Neoplasms -- etiology KW - Alcohol Drinking -- adverse effects KW - Smoking -- adverse effects KW - Body Mass Index KW - Laryngeal Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733169354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Body+mass+index%2C+cigarette+smoking%2C+and+alcohol+consumption+and+cancers+of+the+oral+cavity%2C+pharynx%2C+and+larynx%3A+modeling+odds+ratios+in+pooled+case-control+data.&rft.au=Lubin%2C+Jay+H%3BGaudet%2C+Mia+M%3BOlshan%2C+Andrew+F%3BKelsey%2C+Karl%3BBoffetta%2C+Paolo%3BBrennan%2C+Paul%3BCastellsague%2C+Xavier%3BChen%2C+Chu%3BCurado%2C+Maria+Paula%3BDal+Maso%2C+Luigino%3BDaudt%2C+Alexander+W%3BFabianova%2C+Eleonora%3BFernandez%2C+Leticia%3BW%C3%BCnsch-Filho%2C+Victor%3BFranceschi%2C+Silvia%3BHerrero%2C+Rolando%3BKoifman%2C+Sergio%3BLa+Vecchia%2C+Carlo%3BLazarus%2C+Philip%3BLevi%2C+Fabio%3BLissowska%2C+Jolanta%3BMates%2C+Ioan+Nicolae%3BMatos%2C+Elena%3BMcClean%2C+Michael%3BMenezes%2C+Ana%3BMorgenstern%2C+Hal%3BMuscat%2C+Joshua%3BEluf+Neto%2C+Jose%3BPurdue%2C+Mark+P%3BRudnai%2C+Peter%3BSchwartz%2C+Stephen+M%3BShangina%2C+Oxana%3BSturgis%2C+Erich+M%3BSzeszenia-Dabrowska%2C+Neonilia%3BTalamini%2C+Renato%3BWei%2C+Qingyi%3BWinn%2C+Deborah%3BZhang%2C+Zuo-Feng%3BHashibe%2C+Mia%3BHayes%2C+Richard+B&rft.aulast=Lubin&rft.aufirst=Jay&rft.date=2010-06-15&rft.volume=171&rft.issue=12&rft.spage=1250&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwq088 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-22 N1 - Date created - 2010-06-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1988 Jun 1;48(11):3282-7 [3365707] Int J Cancer. 2004 Dec 10;112(5):901-4 [15386379] Nutr Cancer. 1996;26(2):219-27 [8875559] Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):626-32 [15767341] Int J Cancer. 2006 May 1;118(9):2293-7 [16331628] Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):517-23 [16537710] Ann Oncol. 2006 Sep;17(9):1459-63 [16873426] Lancet Oncol. 2007 Apr;8(4):292-3 [17431955] J Natl Cancer Inst. 2007 May 16;99(10):777-89 [17505073] Alcohol Res Health. 2007;30(1):38-41, 44-7 [17718399] Alcohol Res Health. 2006;29(4):245-54 [17718403] Am J Epidemiol. 2007 Nov 15;166(10):1159-73 [17761691] Nat Genet. 2008 Jun;40(6):707-9 [18500343] Am J Epidemiol. 2009 Oct 15;170(8):937-47 [19745021] Int J Epidemiol. 2010 Aug;39(4):1091-102 [20123951] Carcinogenesis. 2000 Apr;21(4):663-8 [10753201] Int J Cancer. 2000 Aug 1;87(3):444-51 [10897053] Ann Oncol. 2001 Mar;12(3):331-6 [11332144] Br J Cancer. 2001 Nov 30;85(11):1700-5 [11742491] Cancer Causes Control. 2002 Feb;13(1):55-64 [11899118] Br Dent J. 2002 Jun 29;192(12):703-6 [12125796] Cancer Epidemiol Biomarkers Prev. 2002 Aug;11(8):790-3 [12163336] IARC Sci Publ. 2002;156:259-61 [12484183] Cad Saude Publica. 2003 May-Jun;19(3):809-16 [12806483] Br J Cancer. 2003 Nov 3;89(9):1667-71 [14583768] Cancer Causes Control. 2003 Nov;14(9):897-906 [14682447] Oral Oncol. 2004 Feb;40(2):207-13 [14693246] Prev Med. 2004 May;38(5):613-9 [15066364] Alcohol Alcohol. 2004 May-Jun;39(3):155-65 [15082451] Int J Epidemiol. 1994 Dec;23(6):1137-44 [7721514] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwq088 ER - TY - JOUR T1 - Molecular characterization of numr-1 and numr-2: genes that increase both resistance to metal-induced stress and lifespan in Caenorhabditis elegans. AN - 733137751; 20501697 AB - To define the mechanisms involved in the molecular response to the carcinogenic metal cadmium, two novel metal-inducible genes from C. elegans were characterized: numr-1 and numr-2 (nuclear localized metal responsive). numr-1 and numr-2 sequences and cellular patterns of expression are identical, indicating that these are functionally equivalent genes. Constitutive transcription of numr-1 and numr-2 is developmentally regulated and occurs in the intestine, in head and tail neurons, and vulva muscles. Exposure to metals induces numr-1 and numr-2 transcription in pharyngeal and intestinal cells. Other environmental stressors do not affect transcription, indicating that these are metal-specific, stress-responsive genes. NUMR-1 and NUMR-2 target to nuclei and colocalize with HSF-1, suggesting that they may be components of nuclear stress granules. Nematodes overexpressing NUMR-1 and NUMR-2 are resistant to stress and live longer than control animals; likewise reducing expression increases sensitivity to metals and decreases neuromuscular functions. Upstream regulatory regions of both genes contain potential binding sites for DAF-16 and SKN-1, which are components of the insulin-IGF-like signaling pathway. This pathway regulates longevity and stress responses in C. elegans. NUMR-1 and NUMR-2 may function to promote resistance to environmental stressors and longevity, which is mediated by the insulin-IGF-like signaling pathway. JF - Journal of cell science AU - Tvermoes, Brooke E AU - Boyd, Windy A AU - Freedman, Jonathan H AD - Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27009, USA. Y1 - 2010/06/15/ PY - 2010 DA - 2010 Jun 15 SP - 2124 EP - 2134 VL - 123 KW - Caenorhabditis elegans Proteins KW - 0 KW - Environmental Pollutants KW - Nuclear Proteins KW - Numr-1 protein, C elegans KW - Numr-2 protein, C elegans KW - Cadmium KW - 00BH33GNGH KW - Index Medicus KW - Animals KW - Base Sequence KW - Molecular Sequence Data KW - Gene Expression Regulation -- drug effects KW - Amino Acid Sequence KW - Mutation KW - Longevity KW - Stress, Physiological KW - Nuclear Proteins -- genetics KW - Environmental Pollutants -- toxicity KW - Caenorhabditis elegans Proteins -- genetics KW - Caenorhabditis elegans -- drug effects KW - Caenorhabditis elegans Proteins -- metabolism KW - Caenorhabditis elegans -- physiology KW - Cadmium -- toxicity KW - Nuclear Proteins -- metabolism KW - Caenorhabditis elegans -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733137751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cell+science&rft.atitle=Molecular+characterization+of+numr-1+and+numr-2%3A+genes+that+increase+both+resistance+to+metal-induced+stress+and+lifespan+in+Caenorhabditis+elegans.&rft.au=Tvermoes%2C+Brooke+E%3BBoyd%2C+Windy+A%3BFreedman%2C+Jonathan+H&rft.aulast=Tvermoes&rft.aufirst=Brooke&rft.date=2010-06-15&rft.volume=123&rft.issue=&rft.spage=2124&rft.isbn=&rft.btitle=&rft.title=Journal+of+cell+science&rft.issn=1477-9137&rft_id=info:doi/10.1242%2Fjcs.065433 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-30 N1 - Date created - 2010-06-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 1991 Dec;10(12):3959-70 [1935914] Crit Rev Toxicol. 1992;22(3-4):175-201 [1388705] EMBO J. 1992 Dec;11(13):4969-79 [1361171] J Biol Chem. 1993 Feb 5;268(4):2554-64 [8428932] Arch Environ Contam Toxicol. 1997 Jan;32(1):110-4 [9002442] Science. 1997 Nov 14;278(5341):1319-22 [9360933] FEBS Lett. 1998 Nov 27;440(1-2):141-6 [9862443] Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6769-74 [10359787] J Biol Chem. 1999 Oct 15;274(42):29655-65 [10514435] J Biol Chem. 2005 Jun 24;280(25):23684-90 [15840570] Genes Dev. 2005 Oct 1;19(19):2278-83 [16166371] RNA. 2005 Dec;11(12):1848-57 [16314457] Bioinformatics. 2006 Jan 1;22(1):77-87 [16249259] Dalton Trans. 2006 Aug 28;(32):3841-54 [16896443] Nucleic Acids Res. 2006;34(17):4866-77 [16973896] Aging Cell. 2006 Dec;5(6):487-94 [17081160] Cell Metab. 2006 Dec;4(6):429-40 [17141627] FEBS Lett. 2007 May 15;581(10):2055-9 [17475259] PLoS One. 2007;2(12):e1259 [18060055] Dev Cell. 2008 Jan;14(1):76-85 [18194654] Genome Biol. 2007;8(6):R122 [17592649] Cell Calcium. 2008 Feb;43(2):184-95 [17588656] FASEB J. 2008 Feb;22(2):343-54 [17901115] Cell. 2008 Mar 21;132(6):1025-38 [18358814] PLoS Genet. 2008 Apr;4(4):e1000053 [18437200] Science. 2008 May 9;320(5877):811-4 [18467592] Genes Dev. 2008 Oct 1;22(19):2721-35 [18832074] Dev Biol. 2009 Mar 15;327(2):551-65 [19111532] Toxicol Appl Pharmacol. 2009 Aug 1;238(3):209-14 [19236887] Toxicol Appl Pharmacol. 2009 Aug 1;238(3):215-20 [19362100] Cell Mol Life Sci. 2009 Jun;66(11-12):1830-9 [19387551] Neurobiol Aging. 2003 May-Jun;24(3):397-413 [12600716] Neurobiol Aging. 1999 Sep-Oct;20(5):487-502 [10638522] J Environ Pathol Toxicol Oncol. 2000;19(3):201-13 [10983887] Exp Gerontol. 2000 Sep;35(6-7):687-94 [11053658] Genetics. 2000 Nov;156(3):1069-82 [11063685] FASEB J. 2001 Mar;15(3):627-34 [11259381] Toxicol Sci. 2001 Jun;61(2):295-303 [11353138] Curr Biol. 2001 Dec 11;11(24):1975-80 [11747825] Cell. 2001 Dec 28;107(7):893-903 [11779465] Genetics. 1983 Aug;104(4):619-47 [11813735] J Cell Biol. 2002 Mar 4;156(5):775-81 [11877455] Biotechniques. 2002 Apr;32(4):728-30 [11962590] Ind Health. 2002 Apr;40(2):159-66 [12064557] Development. 2002 Aug;129(16):3901-11 [12135927] J Cell Biol. 2002 Aug 19;158(4):639-46 [12186849] Brief Bioinform. 2002 Sep;3(3):265-74 [12230035] J Biol Chem. 2002 Nov 1;277(44):42049-59 [12189149] Toxicology. 2003 Mar 3;184(2-3):157-78 [12499119] J Biol Chem. 2001 Oct 26;276(43):40263-7 [11514557] Exp Gerontol. 2001 Nov;36(10):1609-17 [11672983] Mol Cell Biochem. 2001 Jun;222(1-2):141-7 [11678596] Methods. 2003 Aug;30(4):313-21 [12828945] Dev Cell. 2003 Aug;5(2):197-203 [12919672] J Mol Biol. 2003 Oct 17;333(2):237-47 [14529613] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D411-7 [14681445] Mol Biol Cell. 2004 Feb;15(2):657-64 [14668486] Environ Toxicol Chem. 2004 May;23(5):1235-40 [15180374] Genetics. 2004 Jun;167(2):633-43 [15238517] Genetics. 1984 Sep;108(1):165-80 [6434374] Dev Biol. 1986 Oct;117(2):456-87 [2428682] Arch Toxicol. 1987 Apr;59(6):443-7 [3606391] Toxicol Ind Health. 1988 Dec;4(4):469-78 [3188044] Mol Cell Biol. 1988 Dec;8(12):5339-49 [3244358] Gene. 1990 Sep 14;93(2):189-98 [2121610] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1242/jcs.065433 ER - TY - CPAPER T1 - Constitutive nitric oxide synthase activationis a significant route for nitroglycerin-mediated vasodilation T2 - 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide AN - 754320186; 5874055 JF - 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide AU - Mason, Ronald Y1 - 2010/06/14/ PY - 2010 DA - 2010 Jun 14 KW - Nitric-oxide synthase KW - Vasodilation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754320186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+International+Conference+on+the+Biology%2C+Chemistry%2C+and+Therapeutic+Applications+of+Nitric+Oxide&rft.atitle=Constitutive+nitric+oxide+synthase+activationis+a+significant+route+for+nitroglycerin-mediated+vasodilation&rft.au=Mason%2C+Ronald&rft.aulast=Mason&rft.aufirst=Ronald&rft.date=2010-06-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+International+Conference+on+the+Biology%2C+Chemistry%2C+and+Therapeutic+Applications+of+Nitric+Oxide&rft.issn=&rft_id=info:doi/ L2 - http://www.secretariat.ne.jp/no2010/Program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Pathways associate Nitric Oxide Synthase and Cycloxygenase-2 that Lead to Poor Prognosis in Breast Cancer T2 - 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide AN - 754319808; 5874031 JF - 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide AU - Wink, David Y1 - 2010/06/14/ PY - 2010 DA - 2010 Jun 14 KW - Breast cancer KW - Nitric-oxide synthase KW - Prognosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754319808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+International+Conference+on+the+Biology%2C+Chemistry%2C+and+Therapeutic+Applications+of+Nitric+Oxide&rft.atitle=Pathways+associate+Nitric+Oxide+Synthase+and+Cycloxygenase-2+that+Lead+to+Poor+Prognosis+in+Breast+Cancer&rft.au=Wink%2C+David&rft.aulast=Wink&rft.aufirst=David&rft.date=2010-06-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+International+Conference+on+the+Biology%2C+Chemistry%2C+and+Therapeutic+Applications+of+Nitric+Oxide&rft.issn=&rft_id=info:doi/ L2 - http://www.secretariat.ne.jp/no2010/Program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Genetic regulation of glucose transporter in E. coli B and E. coli K T2 - VIII Metabolic Engineering Conference: Metabolic Engineering for Green Growth AN - 754313132; 5868435 JF - VIII Metabolic Engineering Conference: Metabolic Engineering for Green Growth AU - Shiloach, Joseph Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Glucose transporter KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754313132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=VIII+Metabolic+Engineering+Conference%3A+Metabolic+Engineering+for+Green+Growth&rft.atitle=Genetic+regulation+of+glucose+transporter+in+E.+coli+B+and+E.+coli+K&rft.au=Shiloach%2C+Joseph&rft.aulast=Shiloach&rft.aufirst=Joseph&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=VIII+Metabolic+Engineering+Conference%3A+Metabolic+Engineering+for+Green+Growth&rft.issn=&rft_id=info:doi/ L2 - http://www.engconfintl.org/10ayfin.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Alternative roles for Spo11 during mouse spermatogenesis T2 - 2010 Gordon Research Conference on Meiosis AN - 754286554; 5818761 JF - 2010 Gordon Research Conference on Meiosis AU - Camerini-Otero, Dan Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Spermatogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754286554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Meiosis&rft.atitle=Alternative+roles+for+Spo11+during+mouse+spermatogenesis&rft.au=Camerini-Otero%2C+Dan&rft.aulast=Camerini-Otero&rft.aufirst=Dan&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Meiosis&rft.issn=&rft_id=info:doi/ L2 - 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http://www.grc.org/programs.aspx?year=2010&program=auditory LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Lymphatic involvement in idiopathic pulmonary fibrosis and lymphangioleiomyomatosis T2 - 2010 Gordon Research Conference on Molecular Mechanisms in Lymphatic Function and Disease AN - 754275383; 5818943 JF - 2010 Gordon Research Conference on Molecular Mechanisms in Lymphatic Function and Disease AU - Moss, Joel Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Fibrosis KW - Lung diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754275383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Molecular+Mechanisms+in+Lymphatic+Function+and+Disease&rft.atitle=Lymphatic+involvement+in+idiopathic+pulmonary+fibrosis+and+lymphangioleiomyomatosis&rft.au=Moss%2C+Joel&rft.aulast=Moss&rft.aufirst=Joel&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Molecular+Mechanisms+in+Lymphatic+Function+and+Disease&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=lymphatic LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Cardioprotection in PDE3B KO mice during ex vivo ischemia/reperfusion: Possible mechanisms T2 - 2010 Gordon Research Conference on Cyclic Nucleotide Phosphodiesterases AN - 754274253; 5818602 JF - 2010 Gordon Research Conference on Cyclic Nucleotide Phosphodiesterases AU - Chung, Youn Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Mice KW - Ischemia KW - Reperfusion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Cyclic+Nucleotide+Phosphodiesterases&rft.atitle=Cardioprotection+in+PDE3B+KO+mice+during+ex+vivo+ischemia%2Freperfusion%3A+Possible+mechanisms&rft.au=Chung%2C+Youn&rft.aulast=Chung&rft.aufirst=Youn&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Cyclic+Nucleotide+Phosphodiesterases&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=cyclicnuc LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - National and International Models for 21st Century Research and Clinical Development T2 - 46th Annual Meeting of the Drug Information Association AN - 754273139; 5829048 JF - 46th Annual Meeting of the Drug Information Association AU - Buetow, Ken Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754273139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=National+and+International+Models+for+21st+Century+Research+and+Clinical+Development&rft.au=Buetow%2C+Ken&rft.aulast=Buetow&rft.aufirst=Ken&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - 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http://www.grc.org/programs.aspx?year=2010&program=auditory LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - ODS Research Portfolio and Program Priorities T2 - 46th Annual Meeting of the Drug Information Association AN - 754272725; 5829025 JF - 46th Annual Meeting of the Drug Information Association AU - Coates, Paul Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Portfolios KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=ODS+Research+Portfolio+and+Program+Priorities&rft.au=Coates%2C+Paul&rft.aulast=Coates&rft.aufirst=Paul&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - 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http://www.grc.org/programs.aspx?year=2010&program=bioorg LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - NCCAM's Botanical Research Portfolio with an Emphasis on Diabetes Mellitus Research T2 - 46th Annual Meeting of the Drug Information Association AN - 754266816; 5829026 JF - 46th Annual Meeting of the Drug Information Association AU - Weber, Wendy Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Diabetes mellitus KW - Portfolios KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754266816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=NCCAM%27s+Botanical+Research+Portfolio+with+an+Emphasis+on+Diabetes+Mellitus+Research&rft.au=Weber%2C+Wendy&rft.aulast=Weber&rft.aufirst=Wendy&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Phase 0 Trials for Anticancer Pharmaceuticals T2 - 46th Annual Meeting of the Drug Information Association AN - 754257682; 5829218 JF - 46th Annual Meeting of the Drug Information Association AU - Doroshow, James Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Pharmaceuticals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754257682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Phase+0+Trials+for+Anticancer+Pharmaceuticals&rft.au=Doroshow%2C+James&rft.aulast=Doroshow&rft.aufirst=James&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - CDASH from the NCI caBIG Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754255652; 5829406 JF - 46th Annual Meeting of the Drug Information Association AU - Reeves, Dianne Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754255652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=CDASH+from+the+NCI+caBIG+Perspective&rft.au=Reeves%2C+Dianne&rft.aulast=Reeves&rft.aufirst=Dianne&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Frequent and efficient use of the sister chromatid for DNA double-strand break repair during budding yeast meiosis T2 - 2010 Gordon Research Conference on Meiosis AN - 754252541; 5818775 JF - 2010 Gordon Research Conference on Meiosis AU - Lichten, Michael Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Meiosis KW - DNA damage KW - Double-strand break repair KW - Sister chromatids KW - DNA repair KW - Budding KW - Saccharomyces cerevisiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754252541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Meiosis&rft.atitle=Frequent+and+efficient+use+of+the+sister+chromatid+for+DNA+double-strand+break+repair+during+budding+yeast+meiosis&rft.au=Lichten%2C+Michael&rft.aulast=Lichten&rft.aufirst=Michael&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Meiosis&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=meiosis LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Absence of Cyclophilin B Causes Recessive Osteogenesis Imperfecta but Does Not Impair Type I Collagen Peptidyl-Prolyl Isomerization T2 - 2010 European Human Genetics Conference (ESHG 2010) AN - 839667554; 5914868 JF - 2010 European Human Genetics Conference (ESHG 2010) AU - Marini, J AU - Barnes, A AU - Carter, E AU - Cabral, W AU - Weis, M AU - Chang, W AU - Makareeva, E AU - Leikin, S AU - Rotimi, C AU - Eyre, D AU - Raggio, C Y1 - 2010/06/12/ PY - 2010 DA - 2010 Jun 12 KW - {Q1} KW - Collagen (type I) KW - Isomerization KW - Osteogenesis imperfecta KW - Peptidylprolyl isomerase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839667554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+European+Human+Genetics+Conference+%28ESHG+2010%29&rft.atitle=Absence+of+Cyclophilin+B+Causes+Recessive+Osteogenesis+Imperfecta+but+Does+Not+Impair+Type+I+Collagen+Peptidyl-Prolyl+Isomerization&rft.au=Marini%2C+J%3BBarnes%2C+A%3BCarter%2C+E%3BCabral%2C+W%3BWeis%2C+M%3BChang%2C+W%3BMakareeva%2C+E%3BLeikin%2C+S%3BRotimi%2C+C%3BEyre%2C+D%3BRaggio%2C+C&rft.aulast=Marini&rft.aufirst=J&rft.date=2010-06-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+European+Human+Genetics+Conference+%28ESHG+2010%29&rft.issn=&rft_id=info:doi/ L2 - https://www.eshg.org/fileadmin/www.eshg.org/abstracts/ESHG2010Abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Consortium for Osteogenesis Imperfecta Mutations in the Helical Region of Type I collagen: analysis of genotypephenotype relationship using an updated list that doubles the number of previous reported mutations T2 - 2010 European Human Genetics Conference (ESHG 2010) AN - 839664882; 5914867 JF - 2010 European Human Genetics Conference (ESHG 2010) AU - Forlino, A AU - Barnes, A AU - Cabral, W AU - San Antonio, J AU - Prockop, D AU - De Paepe, A AU - Glorieux, F AU - Lund, A AU - Hartikka, H AU - Kuurila-Svahn, K AU - Cohn, D AU - Dalgleish, R AU - San Giorgi, L AU - Pals, G AU - Lebre, A AU - Mottes, M AU - Ljunggren, O AU - Xu, Y. AU - Byers, P AU - Marini, J Y1 - 2010/06/12/ PY - 2010 DA - 2010 Jun 12 KW - {Q1} KW - Mutation KW - Collagen (type I) KW - Osteogenesis imperfecta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839664882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+European+Human+Genetics+Conference+%28ESHG+2010%29&rft.atitle=Consortium+for+Osteogenesis+Imperfecta+Mutations+in+the+Helical+Region+of+Type+I+collagen%3A+analysis+of+genotypephenotype+relationship+using+an+updated+list+that+doubles+the+number+of+previous+reported+mutations&rft.au=Forlino%2C+A%3BBarnes%2C+A%3BCabral%2C+W%3BSan+Antonio%2C+J%3BProckop%2C+D%3BDe+Paepe%2C+A%3BGlorieux%2C+F%3BLund%2C+A%3BHartikka%2C+H%3BKuurila-Svahn%2C+K%3BCohn%2C+D%3BDalgleish%2C+R%3BSan+Giorgi%2C+L%3BPals%2C+G%3BLebre%2C+A%3BMottes%2C+M%3BLjunggren%2C+O%3BXu%2C+Y.%3BByers%2C+P%3BMarini%2C+J&rft.aulast=Forlino&rft.aufirst=A&rft.date=2010-06-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+European+Human+Genetics+Conference+%28ESHG+2010%29&rft.issn=&rft_id=info:doi/ L2 - https://www.eshg.org/fileadmin/www.eshg.org/abstracts/ESHG2010Abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Proteomics reveals new insights into the causes of hyperammonemia in methylmalonic acidemia T2 - 2010 European Human Genetics Conference (ESHG 2010) AN - 839664702; 5914966 JF - 2010 European Human Genetics Conference (ESHG 2010) AU - Chandler, R AU - Phillips, D AU - Boja, E AU - Carrillo-Carrasco, N AU - Caldovic, L AU - Morizono, H AU - Balaban, R AU - Venditti, C Y1 - 2010/06/12/ PY - 2010 DA - 2010 Jun 12 KW - {Q1} KW - Proteomics KW - Hyperammonemia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839664702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+European+Human+Genetics+Conference+%28ESHG+2010%29&rft.atitle=Proteomics+reveals+new+insights+into+the+causes+of+hyperammonemia+in+methylmalonic+acidemia&rft.au=Chandler%2C+R%3BPhillips%2C+D%3BBoja%2C+E%3BCarrillo-Carrasco%2C+N%3BCaldovic%2C+L%3BMorizono%2C+H%3BBalaban%2C+R%3BVenditti%2C+C&rft.aulast=Chandler&rft.aufirst=R&rft.date=2010-06-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+European+Human+Genetics+Conference+%28ESHG+2010%29&rft.issn=&rft_id=info:doi/ L2 - https://www.eshg.org/fileadmin/www.eshg.org/abstracts/ESHG2010Abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Rapid detection of APC mutations in Slovak FAP families by high resolution melting analysis and protein truncation test T2 - 2010 European Human Genetics Conference (ESHG 2010) AN - 839664398; 5914133 JF - 2010 European Human Genetics Conference (ESHG 2010) AU - Mihok, L AU - Hlinkova, K AU - Ilencikova, D Y1 - 2010/06/12/ PY - 2010 DA - 2010 Jun 12 KW - {Q1} KW - Mutation KW - Melting KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839664398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+European+Human+Genetics+Conference+%28ESHG+2010%29&rft.atitle=Rapid+detection+of+APC+mutations+in+Slovak+FAP+families+by+high+resolution+melting+analysis+and+protein+truncation+test&rft.au=Mihok%2C+L%3BHlinkova%2C+K%3BIlencikova%2C+D&rft.aulast=Mihok&rft.aufirst=L&rft.date=2010-06-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+European+Human+Genetics+Conference+%28ESHG+2010%29&rft.issn=&rft_id=info:doi/ L2 - https://www.eshg.org/fileadmin/www.eshg.org/abstracts/ESHG2010Abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Prognostic significance of interstitial del(14)(q) with deletion IGH(C) in patients with CLL T2 - 2010 European Human Genetics Conference (ESHG 2010) AN - 839663090; 5914111 JF - 2010 European Human Genetics Conference (ESHG 2010) AU - Ruzbacky, R AU - Novakova, P AU - Cermak, M AU - Matuskova, M AU - Ilencikova, D Y1 - 2010/06/12/ PY - 2010 DA - 2010 Jun 12 KW - {Q1} KW - Chronic lymphatic leukemia KW - Interstitial environment KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839663090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+European+Human+Genetics+Conference+%28ESHG+2010%29&rft.atitle=Prognostic+significance+of+interstitial+del%2814%29%28q%29+with+deletion+IGH%28C%29+in+patients+with+CLL&rft.au=Ruzbacky%2C+R%3BNovakova%2C+P%3BCermak%2C+M%3BMatuskova%2C+M%3BIlencikova%2C+D&rft.aulast=Ruzbacky&rft.aufirst=R&rft.date=2010-06-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+European+Human+Genetics+Conference+%28ESHG+2010%29&rft.issn=&rft_id=info:doi/ L2 - https://www.eshg.org/fileadmin/www.eshg.org/abstracts/ESHG2010Abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - SNaPshot as a sensitive molecular tool for prognostic determination of K-RAS mutation status in patients with colorectal cancer in different clinical stages T2 - 2010 European Human Genetics Conference (ESHG 2010) AN - 839661459; 5914154 JF - 2010 European Human Genetics Conference (ESHG 2010) AU - Slamka, T AU - Bartosova, Z AU - Mihok, L AU - Mamrakova, M AU - Jendekova, A AU - Ilencikova, D Y1 - 2010/06/12/ PY - 2010 DA - 2010 Jun 12 KW - {Q1} KW - Colorectal carcinoma KW - Mutation KW - Colorectal cancer KW - K-Ras protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839661459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+European+Human+Genetics+Conference+%28ESHG+2010%29&rft.atitle=SNaPshot+as+a+sensitive+molecular+tool+for+prognostic+determination+of+K-RAS+mutation+status+in+patients+with+colorectal+cancer+in+different+clinical+stages&rft.au=Slamka%2C+T%3BBartosova%2C+Z%3BMihok%2C+L%3BMamrakova%2C+M%3BJendekova%2C+A%3BIlencikova%2C+D&rft.aulast=Slamka&rft.aufirst=T&rft.date=2010-06-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+European+Human+Genetics+Conference+%28ESHG+2010%29&rft.issn=&rft_id=info:doi/ L2 - https://www.eshg.org/fileadmin/www.eshg.org/abstracts/ESHG2010Abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - A founder mutation in LEPRE1 causes lethal recessive Type VIII Osteogenesis Imperfecta and occurs in West Africans and African Americans T2 - 2010 European Human Genetics Conference (ESHG 2010) AN - 839660960; 5914032 JF - 2010 European Human Genetics Conference (ESHG 2010) AU - Marini, J AU - Cabral, W AU - Barnes, A AU - Adeyemo, A AU - Cushing, K AU - Chitayat, D AU - Porter, F AU - Panny, S AU - Majid, F AU - Rebbeck, T AU - Tishkoff, S AU - Bailey- Wilson, J AU - Brody, L AU - Rotimi, C Y1 - 2010/06/12/ PY - 2010 DA - 2010 Jun 12 KW - {Q1} KW - Africa KW - Mutation KW - Ethnic groups KW - Osteogenesis imperfecta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839660960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+European+Human+Genetics+Conference+%28ESHG+2010%29&rft.atitle=A+founder+mutation+in+LEPRE1+causes+lethal+recessive+Type+VIII+Osteogenesis+Imperfecta+and+occurs+in+West+Africans+and+African+Americans&rft.au=Marini%2C+J%3BCabral%2C+W%3BBarnes%2C+A%3BAdeyemo%2C+A%3BCushing%2C+K%3BChitayat%2C+D%3BPorter%2C+F%3BPanny%2C+S%3BMajid%2C+F%3BRebbeck%2C+T%3BTishkoff%2C+S%3BBailey-+Wilson%2C+J%3BBrody%2C+L%3BRotimi%2C+C&rft.aulast=Marini&rft.aufirst=J&rft.date=2010-06-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+European+Human+Genetics+Conference+%28ESHG+2010%29&rft.issn=&rft_id=info:doi/ L2 - https://www.eshg.org/fileadmin/www.eshg.org/abstracts/ESHG2010Abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Attitudes and intentions to undergo invasive prenatal testing: The moderating role of ambivalence T2 - 2010 European Meeting on Psychosocial Aspects of Genetics (EMPAG 2010) AN - 754317827; 5871810 JF - 2010 European Meeting on Psychosocial Aspects of Genetics (EMPAG 2010) AU - Biesecker, B AU - Hankins, M AU - Marteau, T AU - Schwartz, M Y1 - 2010/06/12/ PY - 2010 DA - 2010 Jun 12 KW - Attitudes KW - Prenatal experience KW - Motivation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754317827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+European+Meeting+on+Psychosocial+Aspects+of+Genetics+%28EMPAG+2010%29&rft.atitle=Attitudes+and+intentions+to+undergo+invasive+prenatal+testing%3A+The+moderating+role+of+ambivalence&rft.au=Biesecker%2C+B%3BHankins%2C+M%3BMarteau%2C+T%3BSchwartz%2C+M&rft.aulast=Biesecker&rft.aufirst=B&rft.date=2010-06-12&rft.volume=&rft.issue=2&rft.spage=246&rft.isbn=&rft.btitle=&rft.title=Psychology+of+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/10.1037%2Fa0026917 L2 - https://www.eshg.org/empagprogramme.0.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Common Pathways and Individual Differences: From Model Organisms to Medicine T2 - Genetics 2010: Model Organisms to Human Biology (GENETICS 2010) AN - 754306602; 5860044 JF - Genetics 2010: Model Organisms to Human Biology (GENETICS 2010) AU - Berg, Jeremy Y1 - 2010/06/12/ PY - 2010 DA - 2010 Jun 12 KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754306602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Genetics+2010%3A+Model+Organisms+to+Human+Biology+%28GENETICS+2010%29&rft.atitle=Common+Pathways+and+Individual+Differences%3A+From+Model+Organisms+to+Medicine&rft.au=Berg%2C+Jeremy&rft.aulast=Berg&rft.aufirst=Jeremy&rft.date=2010-06-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Genetics+2010%3A+Model+Organisms+to+Human+Biology+%28GENETICS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.mohb.org/2010/pdf/programbook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Report of an NIAID workshop on dengue animal models AN - 869573899; 14443544 AB - Dengue is a mosquito-borne viral disease of humans that has re-emerged in many parts of the world and has become an important international public health threat. Dengue incidence and geographical spread has dramatically increased in the last few decades and is now affecting most tropical and sub-tropical regions of the world. Despite extensive research efforts for several decades, no vaccines or therapeutics are currently available to prevent and treat dengue infections. One of the main obstacles to the development of countermeasures has been the lack of good animal models that recapitulate dengue pathogenesis in humans and reliably predict the safety and efficacy of countermeasures against dengue. In September 2008, the National Institute of Allergy and Infectious Diseases (NIAID) held a workshop to consider the current state-of-the-art developments in animal models for dengue and discuss strategies to accelerate progress in this field. This report summarizes the main discussions and recommendations that resulted from the meeting. JF - Vaccine AU - Cassetti, MCristina AU - Durbin, Anna AU - Harris, Eva AU - Rico-Hesse, Rebeca AU - Roehrig, John AU - Rothman, Alan AU - Whitehead, Stephen AU - Natarajan, Ramya AU - Laughlin, Catherine AD - National Institute of Allergy and Infectious Diseases, 6610 Rockledge Drive, Bethesda, MD, USA, ccassetti@niaid.nih.gov Y1 - 2010/06/11/ PY - 2010 DA - 2010 Jun 11 SP - 4229 EP - 4234 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 28 IS - 26 SN - 0264-410X, 0264-410X KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Virology & AIDS Abstracts; Immunology Abstracts KW - Dengue KW - Animal KW - Models KW - Human diseases KW - Conferences KW - Animal models KW - Disease control KW - Infection KW - Public health KW - Allergic reactions KW - Hypersensitivity KW - Viral diseases KW - Infectious diseases KW - Vaccines KW - Aquatic insects KW - V 22410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869573899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Report+of+an+NIAID+workshop+on+dengue+animal+models&rft.au=Cassetti%2C+MCristina%3BDurbin%2C+Anna%3BHarris%2C+Eva%3BRico-Hesse%2C+Rebeca%3BRoehrig%2C+John%3BRothman%2C+Alan%3BWhitehead%2C+Stephen%3BNatarajan%2C+Ramya%3BLaughlin%2C+Catherine&rft.aulast=Cassetti&rft.aufirst=MCristina&rft.date=2010-06-11&rft.volume=28&rft.issue=26&rft.spage=4229&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2010.04.045 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Allergic reactions; Human diseases; Infectious diseases; Conferences; Viral diseases; Disease control; Vaccines; Aquatic insects; Public health; Hypersensitivity; Dengue; Animal models; Infection DO - http://dx.doi.org/10.1016/j.vaccine.2010.04.045 ER - TY - CPAPER T1 - Promyelocytic Leukemia: Mrd Detection and Its Correlation with Clinical Outcome T2 - 15th Congress of the European Hematology Association, (EHA 2010) AN - 839641693; 5908050 JF - 15th Congress of the European Hematology Association, (EHA 2010) AU - Gad alla, F AU - Abdelhamid, T AU - Gafaar, E AU - Raslan, H Y1 - 2010/06/10/ PY - 2010 DA - 2010 Jun 10 KW - {Q1} KW - Promyeloid leukemia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839641693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Congress+of+the+European+Hematology+Association%2C+%28EHA+2010%29&rft.atitle=Promyelocytic+Leukemia%3A+Mrd+Detection+and+Its+Correlation+with+Clinical+Outcome&rft.au=Gad+alla%2C+F%3BAbdelhamid%2C+T%3BGafaar%2C+E%3BRaslan%2C+H&rft.aulast=Gad+alla&rft.aufirst=F&rft.date=2010-06-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Congress+of+the+European+Hematology+Association%2C+%28EHA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eventure-online.com/eventure/publicSciProgram.do?congressId LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Phase 1/2a Study of Navitoclax (Abt-263) in Relapsed or Refractory Lymphoid Malignancies T2 - 15th Congress of the European Hematology Association, (EHA 2010) AN - 839636287; 5907494 JF - 15th Congress of the European Hematology Association, (EHA 2010) AU - Wilson, H AU - O'Connor, A AU - Czuczman, S AU - LaCasce, S AU - Gerecitano, F AU - Leonard, P AU - Tulpule, A AU - Xiong, H AU - Chiu, Y L AU - Busman, T AU - Enschede, H AU - Krivoshik, P AU - Humerickhouse, H Y1 - 2010/06/10/ PY - 2010 DA - 2010 Jun 10 KW - {Q1} KW - Malignancy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839636287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Congress+of+the+European+Hematology+Association%2C+%28EHA+2010%29&rft.atitle=Phase+1%2F2a+Study+of+Navitoclax+%28Abt-263%29+in+Relapsed+or+Refractory+Lymphoid+Malignancies&rft.au=Wilson%2C+H%3BO%27Connor%2C+A%3BCzuczman%2C+S%3BLaCasce%2C+S%3BGerecitano%2C+F%3BLeonard%2C+P%3BTulpule%2C+A%3BXiong%2C+H%3BChiu%2C+Y+L%3BBusman%2C+T%3BEnschede%2C+H%3BKrivoshik%2C+P%3BHumerickhouse%2C+H&rft.aulast=Wilson&rft.aufirst=H&rft.date=2010-06-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Congress+of+the+European+Hematology+Association%2C+%28EHA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eventure-online.com/eventure/publicSciProgram.do?congressId LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Impact of Cytogenetic Analysis and Molecular Screening on Risk Stratification and Follow- up in Aml Children in Slovakia T2 - 15th Congress of the European Hematology Association, (EHA 2010) AN - 839634819; 5908122 JF - 15th Congress of the European Hematology Association, (EHA 2010) AU - Leitnerova, Michaela AU - Mikulasova, Zuzana AU - Strbova, Dagmar AU - Ilencikova, Denisa AU - Novakova, Petra AU - Ruzbacky, Rastislav AU - Slamka, Tomas AU - Sejnova, Daniela AU - Kolenova, Alexandra Y1 - 2010/06/10/ PY - 2010 DA - 2010 Jun 10 KW - {Q1} KW - Slovakia KW - Stratification KW - Children KW - Screening KW - Cytogenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839634819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Congress+of+the+European+Hematology+Association%2C+%28EHA+2010%29&rft.atitle=Impact+of+Cytogenetic+Analysis+and+Molecular+Screening+on+Risk+Stratification+and+Follow-+up+in+Aml+Children+in+Slovakia&rft.au=Leitnerova%2C+Michaela%3BMikulasova%2C+Zuzana%3BStrbova%2C+Dagmar%3BIlencikova%2C+Denisa%3BNovakova%2C+Petra%3BRuzbacky%2C+Rastislav%3BSlamka%2C+Tomas%3BSejnova%2C+Daniela%3BKolenova%2C+Alexandra&rft.aulast=Leitnerova&rft.aufirst=Michaela&rft.date=2010-06-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Congress+of+the+European+Hematology+Association%2C+%28EHA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eventure-online.com/eventure/publicSciProgram.do?congressId LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Beacopp-14 vs Beacopp-Esc in Patients with Hodgkin'S Lymphoma from Poor-Prognosis Group: Preliminary Results of Prospective Randomized Multycenter Study T2 - 15th Congress of the European Hematology Association, (EHA 2010) AN - 839634202; 5908383 JF - 15th Congress of the European Hematology Association, (EHA 2010) AU - Kriachok, I AU - Titorenko, I AU - Filonenko, K AU - Aleksik, E AU - Novosad, O AU - Kadnikova, T AU - Kushchevoy, E AU - Martinchik, A AU - Pastushenko, Y Y1 - 2010/06/10/ PY - 2010 DA - 2010 Jun 10 KW - {Q1} KW - Lymphoma KW - Hodgkin's disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839634202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Congress+of+the+European+Hematology+Association%2C+%28EHA+2010%29&rft.atitle=Beacopp-14+vs+Beacopp-Esc+in+Patients+with+Hodgkin%27S+Lymphoma+from+Poor-Prognosis+Group%3A+Preliminary+Results+of+Prospective+Randomized+Multycenter+Study&rft.au=Kriachok%2C+I%3BTitorenko%2C+I%3BFilonenko%2C+K%3BAleksik%2C+E%3BNovosad%2C+O%3BKadnikova%2C+T%3BKushchevoy%2C+E%3BMartinchik%2C+A%3BPastushenko%2C+Y&rft.aulast=Kriachok&rft.aufirst=I&rft.date=2010-06-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Congress+of+the+European+Hematology+Association%2C+%28EHA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eventure-online.com/eventure/publicSciProgram.do?congressId LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Cytokine Production by Graft Cells in Response to Patient's Antigens May Predict the Occurrence of Acute Graft versus Host Disease in Allogeneic Hematopoietic Stem Cell Transplantation from a Sibling T2 - 15th Congress of the European Hematology Association, (EHA 2010) AN - 839632726; 5908921 JF - 15th Congress of the European Hematology Association, (EHA 2010) AU - Kamel, Azza AU - El-Sharkawy, Nahla AU - Kamal, Eman AU - Abd El-Fattah, Raafat AU - Abd El-Moeti, Mohammed AU - Mahmoud, Hossam Y1 - 2010/06/10/ PY - 2010 DA - 2010 Jun 10 KW - {Q1} KW - Stem cells KW - Siblings KW - Graft-versus-host reaction KW - Cytokines KW - Stem cell transplantation KW - Transplantation KW - Antigens KW - Hosts KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839632726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Congress+of+the+European+Hematology+Association%2C+%28EHA+2010%29&rft.atitle=Cytokine+Production+by+Graft+Cells+in+Response+to+Patient%27s+Antigens+May+Predict+the+Occurrence+of+Acute+Graft+versus+Host+Disease+in+Allogeneic+Hematopoietic+Stem+Cell+Transplantation+from+a+Sibling&rft.au=Kamel%2C+Azza%3BEl-Sharkawy%2C+Nahla%3BKamal%2C+Eman%3BAbd+El-Fattah%2C+Raafat%3BAbd+El-Moeti%2C+Mohammed%3BMahmoud%2C+Hossam&rft.aulast=Kamel&rft.aufirst=Azza&rft.date=2010-06-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Congress+of+the+European+Hematology+Association%2C+%28EHA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eventure-online.com/eventure/publicSciProgram.do?congressId LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Application of the Healthy Eating Index-2005: A diet quality metric for multi-level study T2 - 2010 Annual Meeting of the International Society of Behavioral Nutrition and Physical Activity (ISBNPA 2010) AN - 754307105; 5861818 JF - 2010 Annual Meeting of the International Society of Behavioral Nutrition and Physical Activity (ISBNPA 2010) AU - Reedy, Jill AU - Krebs-Smith, Susan Y1 - 2010/06/09/ PY - 2010 DA - 2010 Jun 09 KW - Diets KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754307105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+International+Society+of+Behavioral+Nutrition+and+Physical+Activity+%28ISBNPA+2010%29&rft.atitle=Application+of+the+Healthy+Eating+Index-2005%3A+A+diet+quality+metric+for+multi-level+study&rft.au=Reedy%2C+Jill%3BKrebs-Smith%2C+Susan&rft.aulast=Reedy&rft.aufirst=Jill&rft.date=2010-06-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+International+Society+of+Behavioral+Nutrition+and+Physical+Activity+%28ISBNPA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.togpartners.com/isbnpa/ISBNPA%20Abstract%20Book%20PDF.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Evaluation of individual-level diets and foods available at the communityand macro-level using the Healthy Eating Index-2005 T2 - 2010 Annual Meeting of the International Society of Behavioral Nutrition and Physical Activity (ISBNPA 2010) AN - 754305686; 5861819 JF - 2010 Annual Meeting of the International Society of Behavioral Nutrition and Physical Activity (ISBNPA 2010) AU - Krebs-Smith, Susan AU - Reedy, Jill Y1 - 2010/06/09/ PY - 2010 DA - 2010 Jun 09 KW - Diets KW - Food availability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754305686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+International+Society+of+Behavioral+Nutrition+and+Physical+Activity+%28ISBNPA+2010%29&rft.atitle=Evaluation+of+individual-level+diets+and+foods+available+at+the+communityand+macro-level+using+the+Healthy+Eating+Index-2005&rft.au=Krebs-Smith%2C+Susan%3BReedy%2C+Jill&rft.aulast=Krebs-Smith&rft.aufirst=Susan&rft.date=2010-06-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+International+Society+of+Behavioral+Nutrition+and+Physical+Activity+%28ISBNPA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.togpartners.com/isbnpa/ISBNPA%20Abstract%20Book%20PDF.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Crossing the translational bridge: From behavioral neuroscience to public health T2 - 19th Annual Meeting of the International Behavioral Neuroscience Society (IBNS 2010) AN - 754298194; 5859072 JF - 19th Annual Meeting of the International Behavioral Neuroscience Society (IBNS 2010) AU - Insel, Thomas Y1 - 2010/06/08/ PY - 2010 DA - 2010 Jun 08 KW - Public health KW - Translation KW - Nervous system KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754298194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Annual+Meeting+of+the+International+Behavioral+Neuroscience+Society+%28IBNS+2010%29&rft.atitle=Crossing+the+translational+bridge%3A+From+behavioral+neuroscience+to+public+health&rft.au=Insel%2C+Thomas&rft.aulast=Insel&rft.aufirst=Thomas&rft.date=2010-06-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Annual+Meeting+of+the+International+Behavioral+Neuroscience+Society+%28IBNS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ibnshomepage.org/programIBNS2010final.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Translating Proteomics from the Laboratory to the Clinic T2 - Inaugural Advances in Antibody and Peptide Therapeutics Conference and Exhibition AN - 754269450; 5833886 JF - Inaugural Advances in Antibody and Peptide Therapeutics Conference and Exhibition AU - Rodriguez, Henry Y1 - 2010/06/08/ PY - 2010 DA - 2010 Jun 08 KW - Proteomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754269450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Inaugural+Advances+in+Antibody+and+Peptide+Therapeutics+Conference+and+Exhibition&rft.atitle=Translating+Proteomics+from+the+Laboratory+to+the+Clinic&rft.au=Rodriguez%2C+Henry&rft.aulast=Rodriguez&rft.aufirst=Henry&rft.date=2010-06-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Inaugural+Advances+in+Antibody+and+Peptide+Therapeutics+Conference+and+Exhibition&rft.issn=&rft_id=info:doi/ L2 - http://www.selectbiosciences.com/conferences/files/Agendas2010/CP_AAPT LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Critical Role for IL-1R Signaling and the Inflammasome in the Th1/Th17 cell Adjuvant Activity of Mycobacteria T2 - 2010 Keystone Symposia: Innate Immunity: Mechanisms Linking with Adaptive Immunity (D3) AN - 754275349; 5818211 JF - 2010 Keystone Symposia: Innate Immunity: Mechanisms Linking with Adaptive Immunity (D3) AU - Sher, Alan Y1 - 2010/06/07/ PY - 2010 DA - 2010 Jun 07 KW - Helper cells KW - Interleukin 1 receptors KW - Lymphocytes T KW - Adjuvants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754275349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia%3A+Innate+Immunity%3A+Mechanisms+Linking+with+Adaptive+Immunity+%28D3%29&rft.atitle=Critical+Role+for+IL-1R+Signaling+and+the+Inflammasome+in+the+Th1%2FTh17+cell+Adjuvant+Activity+of+Mycobacteria&rft.au=Sher%2C+Alan&rft.aulast=Sher&rft.aufirst=Alan&rft.date=2010-06-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia%3A+Innate+Immunity%3A+Mechanisms+Linking+with+Adaptive+Immunity+%28D3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - An Innate, Non-NK T Cell with Memory-Like Phenotype Produces Large Amounts of IL-17 Independently of IL-6 and IL-21 T2 - 2010 Keystone Symposia: Innate Immunity: Mechanisms Linking with Adaptive Immunity (D3) AN - 754264764; 5818193 JF - 2010 Keystone Symposia: Innate Immunity: Mechanisms Linking with Adaptive Immunity (D3) AU - Hansen, Anna Y1 - 2010/06/07/ PY - 2010 DA - 2010 Jun 07 KW - Interleukin 21 KW - Interleukin 17 KW - Lymphocytes T KW - Interleukin 6 KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754264764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Keystone+Symposia%3A+Innate+Immunity%3A+Mechanisms+Linking+with+Adaptive+Immunity+%28D3%29&rft.atitle=An+Innate%2C+Non-NK+T+Cell+with+Memory-Like+Phenotype+Produces+Large+Amounts+of+IL-17+Independently+of+IL-6+and+IL-21&rft.au=Hansen%2C+Anna&rft.aulast=Hansen&rft.aufirst=Anna&rft.date=2010-06-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Keystone+Symposia%3A+Innate+Immunity%3A+Mechanisms+Linking+with+Adaptive+Immunity+%28D3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - PON1 Polymorphisms, Organophosphate (OP) Exposure, and Parkinson's Disease (PD) T2 - 26th International Neurotoxicology Conference AN - 754309889; 5864409 JF - 26th International Neurotoxicology Conference AU - Kamel, Freya Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Organophosphates KW - Parkinson's disease KW - Movement disorders KW - Neurodegenerative diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754309889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Neurotoxicology+Conference&rft.atitle=PON1+Polymorphisms%2C+Organophosphate+%28OP%29+Exposure%2C+and+Parkinson%27s+Disease+%28PD%29&rft.au=Kamel%2C+Freya&rft.aulast=Kamel&rft.aufirst=Freya&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Neurotoxicology+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.neurotoxicology.com/conf2009/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Mosquito Duox and Nox interact with midgut peroxidases and modulate Plasmodium infection T2 - 2010 Gordon Research Conference on Nox Family NADPH Oxidases AN - 754299010; 5832701 JF - 2010 Gordon Research Conference on Nox Family NADPH Oxidases AU - Mury, Carolina Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Infection KW - Midgut KW - Peroxidase KW - Nitrogen compounds KW - Oxides KW - Aquatic insects KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754299010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Nox+Family+NADPH+Oxidases&rft.atitle=Mosquito+Duox+and+Nox+interact+with+midgut+peroxidases+and+modulate+Plasmodium+infection&rft.au=Mury%2C+Carolina&rft.aulast=Mury&rft.aufirst=Carolina&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Nox+Family+NADPH+Oxidases&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=nox LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Rapid development of a novel enveloped Chikungunya virus-like particle vaccine for phase I clinical production T2 - III ECI International Conference on Vaccine Technology (ECI 2010) AN - 754295047; 5854159 JF - III ECI International Conference on Vaccine Technology (ECI 2010) AU - Schwartz, Richard Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Particulates KW - Vaccines KW - Virus-like particles KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754295047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=III+ECI+International+Conference+on+Vaccine+Technology+%28ECI+2010%29&rft.atitle=Rapid+development+of+a+novel+enveloped+Chikungunya+virus-like+particle+vaccine+for+phase+I+clinical+production&rft.au=Schwartz%2C+Richard&rft.aulast=Schwartz&rft.aufirst=Richard&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=III+ECI+International+Conference+on+Vaccine+Technology+%28ECI+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.engconfintl.org/10aafin.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Bench scale production of influenza virus from suspension culture of MDCK-siat7e cells T2 - III ECI International Conference on Vaccine Technology (ECI 2010) AN - 754294995; 5854136 JF - III ECI International Conference on Vaccine Technology (ECI 2010) AU - Shiloach, Joseph Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Influenza KW - Suspension culture KW - Influenza virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754294995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=III+ECI+International+Conference+on+Vaccine+Technology+%28ECI+2010%29&rft.atitle=Bench+scale+production+of+influenza+virus+from+suspension+culture+of+MDCK-siat7e+cells&rft.au=Shiloach%2C+Joseph&rft.aulast=Shiloach&rft.aufirst=Joseph&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=III+ECI+International+Conference+on+Vaccine+Technology+%28ECI+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.engconfintl.org/10aafin.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Neuroimaging of human development and neurodevelopmental disorders T2 - 18th Biennial Meeting of the International Society for Developmental Neuroscience (ISDN 2010) AN - 754294304; 5848815 JF - 18th Biennial Meeting of the International Society for Developmental Neuroscience (ISDN 2010) AU - Giedd, Jay Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Neuroimaging KW - Neurodevelopmental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754294304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Biennial+Meeting+of+the+International+Society+for+Developmental+Neuroscience+%28ISDN+2010%29&rft.atitle=Neuroimaging+of+human+development+and+neurodevelopmental+disorders&rft.au=Giedd%2C+Jay&rft.aulast=Giedd&rft.aufirst=Jay&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Biennial+Meeting+of+the+International+Society+for+Developmental+Neuroscience+%28ISDN+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isdn-conference.elsevier.com/programme.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Development of recombinant protein based chemical conjugate malaria vaccines targeting the pre-erthrocytic state, transmission blocking, or both T2 - III ECI International Conference on Vaccine Technology (ECI 2010) AN - 754293676; 5854074 JF - III ECI International Conference on Vaccine Technology (ECI 2010) AU - Narum, David Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Vaccines KW - Malaria KW - Disease control KW - Recombinants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754293676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=III+ECI+International+Conference+on+Vaccine+Technology+%28ECI+2010%29&rft.atitle=Development+of+recombinant+protein+based+chemical+conjugate+malaria+vaccines+targeting+the+pre-erthrocytic+state%2C+transmission+blocking%2C+or+both&rft.au=Narum%2C+David&rft.aulast=Narum&rft.aufirst=David&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=III+ECI+International+Conference+on+Vaccine+Technology+%28ECI+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.engconfintl.org/10aafin.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The non-phagocytic NADPH oxidase Duox1 mediates a positive feedback loop during TCR signaling T2 - 2010 Gordon Research Conference on Nox Family NADPH Oxidases AN - 754293132; 5832718 JF - 2010 Gordon Research Conference on Nox Family NADPH Oxidases AU - Kwon, Jaeyul Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - T-cell receptor KW - NAD(P)H oxidase KW - Feedback KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754293132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Nox+Family+NADPH+Oxidases&rft.atitle=The+non-phagocytic+NADPH+oxidase+Duox1+mediates+a+positive+feedback+loop+during+TCR+signaling&rft.au=Kwon%2C+Jaeyul&rft.aulast=Kwon&rft.aufirst=Jaeyul&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Nox+Family+NADPH+Oxidases&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=nox LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - G protein-Signaling Networks in Cancer: A Synthetic Biology Approach T2 - 2010 Gordon Research Conference on Phosphorylation and G-Protein Mediated Signaling Networks AN - 754287703; 5818713 JF - 2010 Gordon Research Conference on Phosphorylation and G-Protein Mediated Signaling Networks AU - Gutkind, J Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754287703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Phosphorylation+and+G-Protein+Mediated+Signaling+Networks&rft.atitle=G+protein-Signaling+Networks+in+Cancer%3A+A+Synthetic+Biology+Approach&rft.au=Gutkind%2C+J&rft.aulast=Gutkind&rft.aufirst=J&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Phosphorylation+and+G-Protein+Mediated+Signaling+Networks&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=phosphor LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Analysis of the Tyrosine Kinome in Melanoma Reveals Recurrent Mutations in ERBB4 T2 - 2010 Gordon Research Conference on Phosphorylation and G-Protein Mediated Signaling Networks AN - 754286337; 5818710 JF - 2010 Gordon Research Conference on Phosphorylation and G-Protein Mediated Signaling Networks AU - Samuels, Yardena Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Melanoma KW - Mutation KW - ErbB-2 protein KW - Tyrosine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754286337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Phosphorylation+and+G-Protein+Mediated+Signaling+Networks&rft.atitle=Analysis+of+the+Tyrosine+Kinome+in+Melanoma+Reveals+Recurrent+Mutations+in+ERBB4&rft.au=Samuels%2C+Yardena&rft.aulast=Samuels&rft.aufirst=Yardena&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Phosphorylation+and+G-Protein+Mediated+Signaling+Networks&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=phosphor LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The nr4a1-EGFP mouse as a functional sensor of development and activity in the extended striatum T2 - 18th Biennial Meeting of the International Society for Developmental Neuroscience (ISDN 2010) AN - 754285729; 5848940 JF - 18th Biennial Meeting of the International Society for Developmental Neuroscience (ISDN 2010) AU - Davis, M AU - Puhl, H Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Sensors KW - Neostriatum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754285729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Biennial+Meeting+of+the+International+Society+for+Developmental+Neuroscience+%28ISDN+2010%29&rft.atitle=The+nr4a1-EGFP+mouse+as+a+functional+sensor+of+development+and+activity+in+the+extended+striatum&rft.au=Davis%2C+M%3BPuhl%2C+H&rft.aulast=Davis&rft.aufirst=M&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Biennial+Meeting+of+the+International+Society+for+Developmental+Neuroscience+%28ISDN+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isdn-conference.elsevier.com/programme.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Subcellular targeting and function of Duox enzymes T2 - 2010 Gordon Research Conference on Nox Family NADPH Oxidases AN - 754285245; 5832684 JF - 2010 Gordon Research Conference on Nox Family NADPH Oxidases AU - Leto, Thomas Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Enzymes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754285245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Nox+Family+NADPH+Oxidases&rft.atitle=Subcellular+targeting+and+function+of+Duox+enzymes&rft.au=Leto%2C+Thomas&rft.aulast=Leto&rft.aufirst=Thomas&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Nox+Family+NADPH+Oxidases&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=nox LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Mitochondrial calcium dysregulation and cell death T2 - 2010 Gordon Research Conference on Cardiac Regulatory Mechanisms AN - 754280192; 5818354 JF - 2010 Gordon Research Conference on Cardiac Regulatory Mechanisms AU - Murphy, Elizabeth Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Mortality KW - Calcium KW - Cell death KW - Calcium (mitochondrial) KW - Mitochondria KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754280192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Cardiac+Regulatory+Mechanisms&rft.atitle=Mitochondrial+calcium+dysregulation+and+cell+death&rft.au=Murphy%2C+Elizabeth&rft.aulast=Murphy&rft.aufirst=Elizabeth&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Cardiac+Regulatory+Mechanisms&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=cardiac LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Ca and mitochondrial ATP production T2 - 2010 Gordon Research Conference on Cardiac Regulatory Mechanisms AN - 754276051; 5818353 JF - 2010 Gordon Research Conference on Cardiac Regulatory Mechanisms AU - Balaban, Robert Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Mitochondria KW - ATP KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Cardiac+Regulatory+Mechanisms&rft.atitle=Ca+and+mitochondrial+ATP+production&rft.au=Balaban%2C+Robert&rft.aulast=Balaban&rft.aufirst=Robert&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Cardiac+Regulatory+Mechanisms&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=cardiac LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Reprogramming cells in the developing mammary gland T2 - 2010 Gordon Research Conference on Mammary Gland Biology AN - 754270556; 5818739 JF - 2010 Gordon Research Conference on Mammary Gland Biology AU - Smith, Gil Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Mammary gland KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754270556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Mammary+Gland+Biology&rft.atitle=Reprogramming+cells+in+the+developing+mammary+gland&rft.au=Smith%2C+Gil&rft.aulast=Smith&rft.aufirst=Gil&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Mammary+Gland+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=mammglan LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Correction of a carboxyl terminal simian immunodeficiency virus Nef frameshift mutation restores virus replication in macaques. AN - 733935538; 20303562 AB - Previous studies demonstrated that the nef gene is a critical determinant of the pathogenicity of simian immunodeficiency virus (SIV) in macaques. In the present study, we evaluated the effect of a spontaneous frameshift mutation in the C-terminus of the nef gene of the minimally pathogenic SIVsmH4i clone. This clone exhibited a single nucleotide deletion in the nef gene relative to pathogenic SIV clones that resulted in a frameshift and addition of 46 amino acids to the C-terminus of Nef. We generated a corrected version of this clone, SIVsmH4i Nef+ that restored Nef protein expression. Inoculation of macaques with SIVsmH4i resulted in delayed and low levels of peak viremia. This contrasted with improved kinetics and robust peak viremia in macaques inoculated with the corrected version. Despite the restoration of in vivo replication ability, neither clone resulted in memory CD4+ T cell loss or disease in a period of two years. Published by Elsevier Inc. JF - Virology AU - Zheng, Yanfang AU - Ourmanov, Ilnour AU - Goeken, Robert M AU - Whitted, Sonya AU - Brown, Charles R AU - Buckler-White, Alicia AU - Iyengar, Ranjini AU - Plishka, Ronald J AU - Hirsch, Vanessa M AD - Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2010/06/05/ PY - 2010 DA - 2010 Jun 05 SP - 207 EP - 214 VL - 401 IS - 2 KW - Gene Products, nef KW - 0 KW - Index Medicus KW - Virulence KW - Mutagenesis, Site-Directed KW - Animals KW - Humans KW - Suppression, Genetic KW - Viremia KW - CD4 Lymphocyte Count KW - Virus Replication KW - Simian Immunodeficiency Virus -- genetics KW - Frameshift Mutation KW - Gene Products, nef -- genetics KW - Simian Immunodeficiency Virus -- pathogenicity KW - Macaca mulatta -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733935538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Correction+of+a+carboxyl+terminal+simian+immunodeficiency+virus+Nef+frameshift+mutation+restores+virus+replication+in+macaques.&rft.au=Zheng%2C+Yanfang%3BOurmanov%2C+Ilnour%3BGoeken%2C+Robert+M%3BWhitted%2C+Sonya%3BBrown%2C+Charles+R%3BBuckler-White%2C+Alicia%3BIyengar%2C+Ranjini%3BPlishka%2C+Ronald+J%3BHirsch%2C+Vanessa+M&rft.aulast=Zheng&rft.aufirst=Yanfang&rft.date=2010-06-05&rft.volume=401&rft.issue=2&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=1096-0341&rft_id=info:doi/10.1016%2Fj.virol.2010.02.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-10 N1 - Date created - 2010-04-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 1995 Jan 26;332(4):228-32 [7808489] PLoS Pathog. 2009 May;5(5):e1000429 [19436700] Nat Med. 1996 Mar;2(3):338-42 [8612235] J Virol. 1996 Jun;70(6):3741-52 [8648709] Adv Exp Med Biol. 1996;397:7-13 [8718576] J Virol. 1997 Feb;71(2):1608-20 [8995688] J Clin Microbiol. 1999 Jun;37(6):1704-8 [10325311] J Virol. 2005 Dec;79(23):14976-80 [16282498] J Virol. 2006 Jun;80(11):5563-70 [16699037] Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6812-7 [17412836] J Virol. 2007 Sep;81(17):8891-904 [17596304] Curr HIV Res. 2007 Nov;5(6):625-41 [18045118] J Biol Chem. 2008 Apr 25;283(17):11772-84 [18296443] Curr HIV Res. 2008 May;6(3):200-8 [18473783] Vaccine. 2008 Jul 23;26(31):3795-804 [18586360] Nat Med. 2000 Feb;6(2):200-6 [10655110] J Virol. 2000 Mar;74(6):2502-9 [10684264] J Virol. 2000 Mar;74(6):2740-51 [10684290] J Virol. 2000 Mar;74(6):2960-5 [10684319] J Virol. 2000 Oct;74(20):9388-95 [11000207] Trends Biochem Sci. 2001 Jun;26(6):356-63 [11406408] EMBO Rep. 2001 Jul;2(7):580-5 [11463741] J Gen Virol. 2001 Sep;82(Pt 9):2215-23 [11514732] J Virol. 2002 May;76(9):4625-33 [11932428] Nat Med. 2003 Mar;9(3):343-6 [12579198] Nature. 2003 Mar 20;422(6929):307-12 [12646921] Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15131-6 [14627745] J Virol. 2004 Jun;78(11):5745-55 [15140972] Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12324-9 [15297611] Proc Natl Acad Sci U S A. 1985 Jan;82(2):488-92 [3881765] Science. 1985 Jun 7;228(4704):1201-4 [3159089] Vet Pathol. 1988 Nov;25(6):456-67 [2850650] Nature. 1989 Jun 1;339(6223):389-92 [2786147] J Med Primatol. 1989;18(3-4):279-85 [2547963] Nature. 1991 Apr 11;350(6318):508-11 [2014052] Cell. 1991 May 17;65(4):651-62 [2032289] Virology. 1991 Nov;185(1):217-28 [1926774] Biotechniques. 1993 Jan;14(1):70-81 [8424881] Science. 1993 Mar 19;259(5102):1749-54 [8096089] Cell Mol Life Sci. 2008 Sep;65(17):2621-36 [18438604] Retrovirology. 2008;5:84 [18808677] J Virol. 1995 Feb;69(2):955-67 [7815563] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.virol.2010.02.026 ER - TY - CPAPER T1 - The Vision of the NCCCP and Its Potential Impact on Community Cancer Care in the Future T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839654687; 5907003 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Niederhuber, John Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Cancer KW - Vision KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839654687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=The+Vision+of+the+NCCCP+and+Its+Potential+Impact+on+Community+Cancer+Care+in+the+Future&rft.au=Niederhuber%2C+John&rft.aulast=Niederhuber&rft.aufirst=John&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - The Present State of Trials Using Immunoconjugates Targeting Solid Tumors and New Strategies Emerging from the Lab T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839654246; 5907000 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Hassan, Raffit Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Tumors KW - Immunoconjugates KW - Solid tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839654246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=The+Present+State+of+Trials+Using+Immunoconjugates+Targeting+Solid+Tumors+and+New+Strategies+Emerging+from+the+Lab&rft.au=Hassan%2C+Raffit&rft.aulast=Hassan&rft.aufirst=Raffit&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - The Promise and Toxicity of Novel Targeted Therapies in Ovarian Cancer: Hope or Hype? T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839652765; 5907094 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Kohn, Elise Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Toxicity KW - Ovarian carcinoma KW - Ovarian cancer KW - Ovaries KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839652765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=The+Promise+and+Toxicity+of+Novel+Targeted+Therapies+in+Ovarian+Cancer%3A+Hope+or+Hype%3F&rft.au=Kohn%2C+Elise&rft.aulast=Kohn&rft.aufirst=Elise&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Optimizing Care in Advanced Lung Cancer T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839652541; 5907121 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Hassan, Raffit Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Lung cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839652541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=Optimizing+Care+in+Advanced+Lung+Cancer&rft.au=Hassan%2C+Raffit&rft.aulast=Hassan&rft.aufirst=Raffit&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Medical Professionalism in Historical Perspective T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839652508; 5906994 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Martensen, Robert Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Historical account KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839652508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=Medical+Professionalism+in+Historical+Perspective&rft.au=Martensen%2C+Robert&rft.aulast=Martensen&rft.aufirst=Robert&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - International Activities in Cancer and Palliative Care T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839651047; 5907294 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Harford, Joe Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839651047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=International+Activities+in+Cancer+and+Palliative+Care&rft.au=Harford%2C+Joe&rft.aulast=Harford&rft.aufirst=Joe&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - IGF1R Targeting of Translocation-associated Sarcomas T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839648591; 5906038 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Helman, Lee Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Sarcoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839648591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=IGF1R+Targeting+of+Translocation-associated+Sarcomas&rft.au=Helman%2C+Lee&rft.aulast=Helman&rft.aufirst=Lee&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - State of Development for PARP Inhibition T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839647955; 5905032 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Doroshow, James Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Poly(ADP-ribose) polymerase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839647955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=State+of+Development+for+PARP+Inhibition&rft.au=Doroshow%2C+James&rft.aulast=Doroshow&rft.aufirst=James&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Relevance of BRCAness in Selecting Therapy? T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839647868; 5905475 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Kohn, Elise Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839647868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=Relevance+of+BRCAness+in+Selecting+Therapy%3F&rft.au=Kohn%2C+Elise&rft.aulast=Kohn&rft.aufirst=Elise&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Review of National Cancer Institute Symposium on Implementation of International Collaborative Clinical Trials in Cancer Therapies T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839647642; 5904978 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Trimble, Edward Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Cancer KW - Clinical trials KW - Reviews KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839647642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=Review+of+National+Cancer+Institute+Symposium+on+Implementation+of+International+Collaborative+Clinical+Trials+in+Cancer+Therapies&rft.au=Trimble%2C+Edward&rft.aulast=Trimble&rft.aufirst=Edward&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Angiogenic Targeting in Castration-resistant Prostate Cancer T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839647572; 5905471 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Dahut, William Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Prostate cancer KW - Angiogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839647572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=Angiogenic+Targeting+in+Castration-resistant+Prostate+Cancer&rft.au=Dahut%2C+William&rft.aulast=Dahut&rft.aufirst=William&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Vitamin D: Should We Be Supplementing to Prevent Cancer? T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839643159; 5904008 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Milner, John Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Cancer KW - Vitamin D KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=Vitamin+D%3A+Should+We+Be+Supplementing+to+Prevent+Cancer%3F&rft.au=Milner%2C+John&rft.aulast=Milner&rft.aufirst=John&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Emerging Evidence for a Genetic Risk of Prostate Cancer T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839639662; 5904022 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Ostrander, Elaine Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Prostate cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839639662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=Emerging+Evidence+for+a+Genetic+Risk+of+Prostate+Cancer&rft.au=Ostrander%2C+Elaine&rft.aulast=Ostrander&rft.aufirst=Elaine&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - National Cancer Institute Training and Career Development Grants T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839639336; 5903865 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Wiest, Jonathan Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Cancer KW - Grants KW - Training KW - Careers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839639336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=National+Cancer+Institute+Training+and+Career+Development+Grants&rft.au=Wiest%2C+Jonathan&rft.aulast=Wiest&rft.aufirst=Jonathan&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - New Designs for Phase III Clinical Trials T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839637930; 5903976 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Simon, Richard Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Clinical trials KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839637930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=New+Designs+for+Phase+III+Clinical+Trials&rft.au=Simon%2C+Richard&rft.aulast=Simon&rft.aufirst=Richard&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Streamlining the Extramural Clinical Trials System T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839637624; 5906577 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Doroshow, James Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Clinical trials KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839637624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=Streamlining+the+Extramural+Clinical+Trials+System&rft.au=Doroshow%2C+James&rft.aulast=Doroshow&rft.aufirst=James&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - JOUR T1 - Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases AN - 759309273; 13200228 AB - NEIL1, the mammalian homolog of Escherichia coli endonuclease VIII, is a DNA glycosylase that repairs ring-fragmented purines, saturated pyrimidines and several oxidative lesions like 5-hydroxyuracil, 5-hydroxycytosine, etc. Previous studies from our laboratory have shown that Werner Syndrome protein (WRN), one of the five human RecQ helicases, stimulates NEIL1 DNA glycosylase activity on oxidative DNA lesions. The goal of this study was to extend this observation and analyze the interaction between NEIL1 and all five human RecQ helicases. The DNA substrate specificity of the interaction between WRN and NEIL1 was also analyzed. The results indicate that WRN is the only human RecQ helicase that stimulates NEIL1 DNA glycosylase activity, and that this stimulation requires a double-stranded DNA substrate. JF - DNA Repair AU - Popuri, Venkateswarlu AU - Croteau, Deborah L AU - Bohr, Vilhelm A AD - Laboratory of Molecular Gerontology, National Institute on Aging, NIH, 251 Bayview Blvd, Suite 100, Baltimore, MD 21224, USA, vbohr@nih.gov Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 SP - 636 EP - 642 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 9 IS - 6 SN - 1568-7864, 1568-7864 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - DNA glycosylase KW - Escherichia coli KW - N 14820:DNA Metabolism & Structure KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759309273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+Repair&rft.atitle=Substrate+specific+stimulation+of+NEIL1+by+WRN+but+not+the+other+human+RecQ+helicases&rft.au=Popuri%2C+Venkateswarlu%3BCroteau%2C+Deborah+L%3BBohr%2C+Vilhelm+A&rft.aulast=Popuri&rft.aufirst=Venkateswarlu&rft.date=2010-06-04&rft.volume=9&rft.issue=6&rft.spage=636&rft.isbn=&rft.btitle=&rft.title=DNA+Repair&rft.issn=15687864&rft_id=info:doi/10.1016%2Fj.dnarep.2010.02.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - DNA glycosylase; Escherichia coli DO - http://dx.doi.org/10.1016/j.dnarep.2010.02.012 ER - TY - JOUR T1 - Detecting internally symmetric protein structures AN - 745723148; 13204456 AB - Many functional proteins have a symmetric structure. Most of these are multimeric complexes, which are made of non-symmetric monomers arranged in a symmetric manner. However, there are also a large number of proteins that have a symmetric structure in the monomeric state. These internally symmetric proteins are interesting objects from the point of view of their folding, function, and evolution. Most algorithms that detect the internally symmetric proteins depend on finding repeating units of similar structure and do not use the symmetry information. We describe a new method, called SymD, for detecting symmetric protein structures. The SymD procedure works by comparing the structure to its own copy after the copy is circularly permuted by all possible number of residues. The procedure is relatively insensitive to symmetry-breaking insertions and deletions and amplifies positive signals from symmetry. It finds 70% to 80% of the TIM barrel fold domains in the ASTRAL 40 domain database and 100% of the beta-propellers as symmetric. More globally, 10% to 15% of the proteins in the ASTRAL 40 domain database may be considered symmetric according to this procedure depending on the precise cutoff value used to measure the degree of perfection of the symmetry. Symmetrical proteins occur in all structural classes and can have a closed, circular structure, a cylindrical barrel-like structure, or an open, helical structure. SymD is a sensitive procedure for detecting internally symmetric protein structures. Using this procedure, we estimate that 10% to 15% of the known protein domains may be considered symmetric. We also report an initial, overall view of the types of symmetries and symmetric folds that occur in the protein domain structure universe. JF - BMC Bioinformatics AU - Kim, Changhoon AU - Basner, Jodi AU - Lee, Byungkook AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bldg. 37, Room 5120, 37 Convent Dr MSC 4264, Bethesda MD 20892-4264 USA Y1 - 2010/06/03/ PY - 2010 DA - 2010 Jun 03 SP - 303 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 11 KW - Biotechnology and Bioengineering Abstracts KW - Protein structure KW - Monomers KW - Databases KW - Protein folding KW - Algorithms KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745723148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Detecting+internally+symmetric+protein+structures&rft.au=Kim%2C+Changhoon%3BBasner%2C+Jodi%3BLee%2C+Byungkook&rft.aulast=Kim&rft.aufirst=Changhoon&rft.date=2010-06-03&rft.volume=11&rft.issue=&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-11-303 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Monomers; Protein structure; Databases; Protein folding; Algorithms; Bioinformatics DO - http://dx.doi.org/10.1186/1471-2105-11-303 ER - TY - CPAPER T1 - Immunoaffinity-Mass Spectrometry Approach for Identification of N-Formyl Kynurenine in Proteins T2 - 37th Northeast Regional Meeting of the American Chemical Society (NERM 2010) AN - 754319416; 5874819 JF - 37th Northeast Regional Meeting of the American Chemical Society (NERM 2010) AU - Perdivara, Irina AU - Tomer, Kenneth AU - Ehrenshaft, Marilyn AU - Mason, Ronald Y1 - 2010/06/02/ PY - 2010 DA - 2010 Jun 02 KW - Spectrometry KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754319416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=37th+Northeast+Regional+Meeting+of+the+American+Chemical+Society+%28NERM+2010%29&rft.atitle=Immunoaffinity-Mass+Spectrometry+Approach+for+Identification+of+N-Formyl+Kynurenine+in+Proteins&rft.au=Perdivara%2C+Irina%3BTomer%2C+Kenneth%3BEhrenshaft%2C+Marilyn%3BMason%2C+Ronald&rft.aulast=Perdivara&rft.aufirst=Irina&rft.date=2010-06-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=37th+Northeast+Regional+Meeting+of+the+American+Chemical+Society+%28NERM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www2.potsdam.edu/walkerma/NERM2010_FullProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Opioid & Alcohol Action: The Role of Brain & Spinal Cord Innate Immune Signalling T2 - 17th Annual Meeting of the Psychoneuroimmunology Research Society AN - 754310565; 5864523 JF - 17th Annual Meeting of the Psychoneuroimmunology Research Society AU - Hutchinson, M AU - Wu, Y. AU - Liu, L AU - Phipps, S AU - Rice, K AU - Coller, J AU - Watkins, L AU - Somogyi, A Y1 - 2010/06/02/ PY - 2010 DA - 2010 Jun 02 KW - Alcohols KW - Brain KW - Spinal cord KW - Opioids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754310565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=17th+Annual+Meeting+of+the+Psychoneuroimmunology+Research+Society&rft.atitle=Opioid+%26amp%3B+Alcohol+Action%3A+The+Role+of+Brain+%26amp%3B+Spinal+Cord+Innate+Immune+Signalling&rft.au=Hutchinson%2C+M%3BWu%2C+Y.%3BLiu%2C+L%3BPhipps%2C+S%3BRice%2C+K%3BColler%2C+J%3BWatkins%2C+L%3BSomogyi%2C+A&rft.aulast=Hutchinson&rft.aufirst=M&rft.date=2010-06-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=17th+Annual+Meeting+of+the+Psychoneuroimmunology+Research+Society&rft.issn=&rft_id=info:doi/ L2 - https://www.pnirs.org/resources/docs/PNIRS%20programme%20May19%20FINAL LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - National Institute of Mental Health Research Funding Opportunities: Questions and Answers Session T2 - Sixth World Congress of Congress of Behavioral and Cognitive Therapies (WCBCT 2010) AN - 754252990; 5824369 JF - Sixth World Congress of Congress of Behavioral and Cognitive Therapies (WCBCT 2010) AU - Muehrer, P Y1 - 2010/06/02/ PY - 2010 DA - 2010 Jun 02 KW - Mental disorders KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754252990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+World+Congress+of+Congress+of+Behavioral+and+Cognitive+Therapies+%28WCBCT+2010%29&rft.atitle=National+Institute+of+Mental+Health+Research+Funding+Opportunities%3A+Questions+and+Answers+Session&rft.au=Muehrer%2C+P&rft.aulast=Muehrer&rft.aufirst=P&rft.date=2010-06-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+World+Congress+of+Congress+of+Behavioral+and+Cognitive+Therapies+%28WCBCT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://wcbct2010.abstractcentral.com/planner LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Risk of Colon Cancer and Coffee, Tea, and Sugar-Sweetened Soft Drink Intake: Pooled Analysis of Prospective Cohort Studies AN - 744701515; 13114147 AB - Background The relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved. Methods We investigated prospectively the association between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk in a pooled analysis of primary data from 13 cohort studies. Among 731441 participants followed for up to 6-20 years, 5604 incident colon cancer case patients were identified. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. Results Compared with nonconsumers, the pooled multivariable relative risks were 1.07 (95% CI = 0.89 to 1.30, P sub(trend) = .68) for coffee consumption greater than 1400 g/d (about six 8-oz cups) and 1.28 (95% CI = 1.02 to 1.61, P sub(trend) = .01) for tea consumption greater than 900 g/d (about four 8-oz cups). For sugar-sweetened carbonated soft drink consumption, the pooled multivariable relative risk comparing consumption greater than 550 g/d (about 18 oz) to nonconsumers was 0.94 (95% CI = 0.66 to 1.32, P sub(trend) = .91). No statistically significant between-studies heterogeneity was observed for the highest category of each beverage consumed (P > .20). The observed associations did not differ by sex, smoking status, alcohol consumption, body mass index, physical activity, or tumor site (P > .05). Conclusions Drinking coffee or sugar-sweetened carbonated soft drinks was not associated with colon cancer risk. However, a modest positive association with higher tea consumption is possible and requires further study. JF - Journal of the National Cancer Institute AU - Zhang, Xuehong AU - Albanes, Demetrius AU - Beeson, WLawrence AU - van den Brandt, Piet A AU - Buring, Julie E AU - Flood, Andrew AU - Freudenheim, Jo L AU - Giovannucci, Edward L AU - Goldbohm, RAlexandra AU - Jaceldo-Siegl, Karen AU - Jacobs, Eric J AU - Krogh, Vittorio AU - Larsson, Susanna C AU - Marshall, James R AU - McCullough, Marjorie L AU - Miller, Anthony B AU - Robien, Kim AU - Rohan, Thomas E AU - Schatzkin, Arthur AU - Sieri, Sabina AU - Spiegelman, Donna AU - Virtamo, Jarmo AU - Wolk, Alicja AU - Willett, Walter C AU - Zhang, Shumin M AU - Smith-Warner, Stephanie A AD - Affiliations of authors: Department of Nutrition (XZ, ELG, WCW, SAS-W), Department of Epidemiology (XZ, JEB, ELG, DS, WCW, SAS-W), and Department of Biostatistics (DS), Harvard School of Public Health, Boston, MA; Nutritional Epidemiology Branch (DA) and Division of Cancer Epidemiology and Genetics, Department of Health and Human Services (AS), National Cancer Institute, National Institute of Health, Bethesda, MD; The Center for Health Research, Loma Linda University School of Public Health, Loma Linda, CA (WLB, KJ-S); Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands (PAvdB); Division of Preventive Medicine, Department of Medicine (JEB, SMZ) and Channing Laboratory, Department of Medicine (ELG, WCW), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo, NY (JLF); Department of Foo, pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu Y1 - 2010/06/02/ PY - 2010 DA - 2010 Jun 02 SP - 771 EP - 783 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 11 SN - 0027-8874, 0027-8874 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Coffee KW - Physical activity KW - Statistical analysis KW - tumors KW - tea KW - Models KW - Smoking KW - body mass KW - Tea KW - physical activity KW - Ethanol KW - Sex KW - Alcohol KW - Data processing KW - Beverages KW - coffee KW - Tumors KW - Colon cancer KW - Cancer KW - Drinking behavior KW - Body mass index KW - X 24380:Social Poisons & Drug Abuse KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744701515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Risk+of+Colon+Cancer+and+Coffee%2C+Tea%2C+and+Sugar-Sweetened+Soft+Drink+Intake%3A+Pooled+Analysis+of+Prospective+Cohort+Studies&rft.au=Zhang%2C+Xuehong%3BAlbanes%2C+Demetrius%3BBeeson%2C+WLawrence%3Bvan+den+Brandt%2C+Piet+A%3BBuring%2C+Julie+E%3BFlood%2C+Andrew%3BFreudenheim%2C+Jo+L%3BGiovannucci%2C+Edward+L%3BGoldbohm%2C+RAlexandra%3BJaceldo-Siegl%2C+Karen%3BJacobs%2C+Eric+J%3BKrogh%2C+Vittorio%3BLarsson%2C+Susanna+C%3BMarshall%2C+James+R%3BMcCullough%2C+Marjorie+L%3BMiller%2C+Anthony+B%3BRobien%2C+Kim%3BRohan%2C+Thomas+E%3BSchatzkin%2C+Arthur%3BSieri%2C+Sabina%3BSpiegelman%2C+Donna%3BVirtamo%2C+Jarmo%3BWolk%2C+Alicja%3BWillett%2C+Walter+C%3BZhang%2C+Shumin+M%3BSmith-Warner%2C+Stephanie+A&rft.aulast=Zhang&rft.aufirst=Xuehong&rft.date=2010-06-02&rft.volume=102&rft.issue=11&rft.spage=771&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjq107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Coffee; Risk assessment; Beverages; Data processing; Physical activity; Statistical analysis; Colon cancer; Tumors; Models; Smoking; Tea; Drinking behavior; Body mass index; Sex; Ethanol; Alcohol; body mass; coffee; tumors; physical activity; tea; Cancer DO - http://dx.doi.org/10.1093/jnci/djq107 ER - TY - JOUR T1 - Winning a Won Game: Caffeine Panacea for Obesity Syndemic AN - 954598120; 14160288 AB - Over the past decades, chronic sleep reduction and a concurrent development of obesity have been recognized as a common problem in the industrialized world. Among its numerous untoward effects, there is a possibility that insomnia is also a major contributor to obesity. This attribution poses a problem for caffeine, an inexpensive, "natural" agent that is purported to improve a number of conditions and is often indicated in a long-term pharmacotherapy in the context of weight management. The present study used the "common target" approach by exploring the tentative shared molecular networks of insomnia and adiposity. It discusses caffeine targets beyond those associated with adenosine signaling machinery, phosphodiesterases, and calcium release channels. Here, we provide a view suggesting that caffeine could exert some of its effects by acting on several signaling complexes composed of HIF-1 alpha /VEGF/IL-8 along with NO, TNF- alpha , IL1, and GHRH, among others. Although the relevance of these targets to the reported therapeutic effects of caffeine has remained difficult to assess, the utilization of caffeine efficacies and potencies recommend its repurposing for development of novel therapeutic approaches. Among indications mentioned, are neuroprotective, nootropic, antioxidant, proliferative, anti-fibrotic, and anti-angiogenic that appear under a variety of dissimilar diagnostic labels comorbid with obesity. In the absence of safe and efficacious antiobesity agents, caffeine remains an attractive adjuvant. JF - Current Neuropharmacology AU - Myslobodsky, M AU - Eldan, A AD - Howard University Graduate School (Washington, DC); Clinical Brain Disorders Branch, NIMH/National Institutes of Health (Bethesda, USA) Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 149 EP - 160 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands VL - 8 IS - 2 SN - 1570-159X, 1570-159X KW - Physical Education Index; CSA Neurosciences Abstracts KW - Insomnia KW - Antioxidants KW - Attribution KW - Interleukin 1 KW - Winning KW - Neuroprotection KW - Adjuvants KW - Interleukin 8 KW - Growth hormone-releasing hormone KW - Calcium release channels KW - Recruiting KW - Caffeine KW - Drugs KW - Self efficacy KW - Vascular endothelial growth factor KW - Obesity KW - Weight control KW - Sleep disorders KW - Hypoxia-inducible factor 1 alpha KW - Sleep KW - Adipose tissue KW - Nitric oxide KW - Tumor necrosis factor- alpha KW - Adenosine KW - phosphodiesterase KW - N3 11028:Neuropharmacology & toxicology KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954598120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Neuropharmacology&rft.atitle=Winning+a+Won+Game%3A+Caffeine+Panacea+for+Obesity+Syndemic&rft.au=Myslobodsky%2C+M%3BEldan%2C+A&rft.aulast=Myslobodsky&rft.aufirst=M&rft.date=2010-06-01&rft.volume=8&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Current+Neuropharmacology&rft.issn=1570159X&rft_id=info:doi/10.2174%2F157015910791233213 LA - English DB - Physical Education Index N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-05-07 N1 - SubjectsTermNotLitGenreText - Insomnia; Obesity; Attribution; Weight control; Sleep; Winning; Recruiting; Drugs; Self efficacy; Vascular endothelial growth factor; Antioxidants; Sleep disorders; Interleukin 1; Neuroprotection; Adjuvants; Hypoxia-inducible factor 1 alpha; Interleukin 8; Growth hormone-releasing hormone; Calcium release channels; Adipose tissue; Nitric oxide; Caffeine; Tumor necrosis factor- alpha; Adenosine; phosphodiesterase DO - http://dx.doi.org/10.2174/157015910791233213 ER - TY - JOUR T1 - Paracetamol, Poison, and Polio: Why Boorse's Account of Function Fails to Distinguish Health and Disease AN - 920790854; 16173012 AB - Christopher Boorse's Bio Statistical Theory (BST) defines health as the absence of disease, and disease as the adverse departure from normal species functioning. This paper presents a two-pronged problem for this account. First I demonstrate that, in order to accurately account for dynamic physiological functions, Boorse's account of normal function needs to be modified to index functions against situations. I then demonstrate that if functions are indexed against situations, the BST can no longer account for diseases that result from specific environmental factors. The BST is impaled on either horn of this dilemma and therefore must be dismissed.1 A More Sophisticated Version of the BST1.1 Normal function 1.2 Health as a quantitative normal function 1.3 Dispositional function 1.4 Situation-specific function 1.5 Summary and justification 2 An Inescapable Problem2.1 Harmful environments and situation-specific diseases 2.2 A detailed example 2.3 Two possible replies refuted 2.4 Conclusion of Section 2 3 Potential Ways out of the Dilemma3.1 Distinguishing between harmful and normal situations 3.2 First solution: Statistically abnormal environments3.2.1 Rare non-harmful environments 3.2.2 Harmful non-rare environments 3.3 Second solution: Adverse environments 3.4 Third solution: Non-natural environments 3.5 Interim conclusion and diagnosis 3.6 Abusing the function concept? 4 The BST Refuted4.1 A central tension 4.2 Differences with previous arguments 4.3 Conclusion JF - British Journal for the Philosophy of Science AU - Kingma, Elselijn AD - Department of Bioethics Clinical Centre, National Institutes of Health 10 Center Drive, Room 1C118 Bethesda, MD 20892, USA, kingmae16173012@cc.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 241 EP - 264 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 61 IS - 2 SN - 0007-0882, 0007-0882 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Statistics KW - paracetamol KW - Physiology KW - Philosophy KW - Environmental factors KW - V 22490:Miscellaneous KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920790854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+for+the+Philosophy+of+Science&rft.atitle=Paracetamol%2C+Poison%2C+and+Polio%3A+Why+Boorse%27s+Account+of+Function+Fails+to+Distinguish+Health+and+Disease&rft.au=Kingma%2C+Elselijn&rft.aulast=Kingma&rft.aufirst=Elselijn&rft.date=2010-06-01&rft.volume=61&rft.issue=2&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=British+Journal+for+the+Philosophy+of+Science&rft.issn=00070882&rft_id=info:doi/10.1093%2Fbjps%2Faxp034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - paracetamol; Statistics; Philosophy; Environmental factors; Physiology DO - http://dx.doi.org/10.1093/bjps/axp034 ER - TY - JOUR T1 - 'Exact permutation tests for correlated binomial variables' by J. Yu, J. L. Kepner and R. Iyer Biometrical Journal (2009) 51, 899-914 Article: http://dx.doi.org/10.1002/bimj.200900082. Authors' reply: http://dx.doi.org/10.1002/bimj.201000094. AN - 888106006; 15039075 AB - No abstract is available for this article. JF - Biometrical Journal AU - Berger, Vance W Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 436 EP - 437 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 52 IS - 3 SN - 1521-4036, 1521-4036 KW - Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888106006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=%27Exact+permutation+tests+for+correlated+binomial+variables%27+by+J.+Yu%2C+J.+L.+Kepner+and+R.+Iyer+Biometrical+Journal+%282009%29+51%2C+899-914+Article%3A+http%3A%2F%2Fdx.doi.org%2F10.1002%2Fbimj.200900082.+Authors%27+reply%3A+http%3A%2F%2Fdx.doi.org%2F10.1002%2Fbimj.201000094.&rft.au=Berger%2C+Vance+W&rft.aulast=Berger&rft.aufirst=Vance&rft.date=2010-06-01&rft.volume=52&rft.issue=3&rft.spage=436&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=15214036&rft_id=info:doi/10.1002%2Fbimj.201000012 L2 - http://onlinelibrary.wiley.com/doi/10.1002/bimj.201000012/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1002/bimj.201000012 ER - TY - JOUR T1 - The validity and structure of culture-level personality scores: data from ratings of young adolescents AN - 851745125; 4165161 AB - We examined properties of culture-level personality traits in ratings of targets (N=5,109) ages 12 to 17 in 24 cultures. Aggregate scores were generalizable across gender, age, and relationship groups and showed convergence with culture-level scores from previous studies of self-reports and observer ratings of adults, but they were unrelated to national character stereotypes. Trait profiles also showed cross-study agreement within most cultures, 8 of which had not previously been studied. Multidimensional scaling showed that Western and non-Western cultures clustered along a dimension related to Extraversion. A culture-level factor analysis replicated earlier findings of a broad Extraversion factor but generally resembled the factor structure found in individuals. Continued analysis of aggregate personality scores is warranted. Adapted from the source document. Reprinted by permission of Blackwell Publishers JF - Journal of personality AU - McCrae, Robert R AU - Terracciano, Antonio AU - Fruyt, Filip de AU - Bolle, Marleen de AU - Gelfand, Michele J AU - Costa, Jr., Paul T. AD - National Institute on Aging Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 815 EP - 838 VL - 78 IS - 3 SN - 0022-3506, 0022-3506 KW - Sociology KW - Culture KW - Research methods KW - Adolescence KW - Validity KW - Personality KW - Adolescents KW - Youth KW - Stereotypes KW - Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/851745125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality&rft.atitle=The+validity+and+structure+of+culture-level+personality+scores%3A+data+from+ratings+of+young+adolescents&rft.au=McCrae%2C+Robert+R%3BTerracciano%2C+Antonio%3BFruyt%2C+Filip+de%3BBolle%2C+Marleen+de%3BGelfand%2C+Michele+J%3BCosta%2C+Jr.%2C+Paul+T.&rft.aulast=McCrae&rft.aufirst=Robert&rft.date=2010-06-01&rft.volume=78&rft.issue=3&rft.spage=815&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality&rft.issn=00223506&rft_id=info:doi/10.1111%2Fj.1467-6494.2010.00634.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9416 2153; 13779 652 5676 646 6091; 593; 590 652 5676 646 6091; 3198; 7994; 10919; 13230 2688 2449 10404; 12247 11814 DO - http://dx.doi.org/10.1111/j.1467-6494.2010.00634.x ER - TY - JOUR T1 - QSAR models for predicting cathepsin B inhibition by small molecules--Continuous and binary QSAR models to classify cathepsin B inhibition activities of small molecules AN - 760206439; 13201917 AB - Cathepsin B is a potential target for the development of drugs to treat several important human diseases. A number of inhibitors targeting this protein have been developed in the past several years. Recently, a group of small molecules were identified to have inhibitory activity against cathepsin B through high throughput screening (HTS) tests. In this study, traditional continuous and binary QSAR models were built to classify the biological activities of previously identified compounds and to distinguish active compounds from inactive compounds for drug development based on the calculated molecular and physicochemical properties. Strong correlations were obtained for the continuous QSAR models with regression correlation coefficients (r 2) and cross-validated correlation coefficients (q 2) of 0.77 and 0.61 for all compounds, and 0.82 and 0.68 for the compound set excluding 3 outliers, respectively. The models were further validated through the leave-one-out (LOO) method and the training-test set method. The binary models demonstrated a strong level of predictability in distinguishing the active compounds from inactive compounds with accuracies of 0.89 and 0.94 for active and inactive compounds, respectively, in non-cross-validated models. Similar results were obtained for the cross-validated models. Collectively, these results demonstrate the models' ability to discriminate between active and inactive compounds, suggesting that the models may be used to pre-screen compounds to facilitate compound optimization and to design novel inhibitors for drug development. JF - Journal of Molecular Graphics and Modelling AU - Zhou, Zhigang AU - Wang, Yanli AU - Bryant, Stephen H AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 714 EP - 727 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 28 IS - 8 SN - 1093-3263, 1093-3263 KW - Biotechnology and Bioengineering Abstracts KW - Binary QSAR KW - Regression KW - Partial least squares KW - Docking KW - Cathepsin B protein KW - Screening KW - PubChem bioassay KW - Molecular modelling KW - Cathepsin B KW - Physicochemical properties KW - Regression analysis KW - Drug development KW - high-throughput screening KW - Structure-activity relationships KW - Models KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760206439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Graphics+and+Modelling&rft.atitle=QSAR+models+for+predicting+cathepsin+B+inhibition+by+small+molecules--Continuous+and+binary+QSAR+models+to+classify+cathepsin+B+inhibition+activities+of+small+molecules&rft.au=Zhou%2C+Zhigang%3BWang%2C+Yanli%3BBryant%2C+Stephen+H&rft.aulast=Zhou&rft.aufirst=Zhigang&rft.date=2010-06-01&rft.volume=28&rft.issue=8&rft.spage=714&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Graphics+and+Modelling&rft.issn=10933263&rft_id=info:doi/10.1016%2Fj.jmgm.2010.01.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Physicochemical properties; Cathepsin B; Regression analysis; high-throughput screening; Drug development; Structure-activity relationships; Models DO - http://dx.doi.org/10.1016/j.jmgm.2010.01.009 ER - TY - JOUR T1 - Prediction of passive blood-brain partitioning: Straightforward and effective classification models based on in silico derived physicochemical descriptors AN - 760204641; 13201897 AB - The distribution of compounds between blood and brain is a very important consideration for new candidate drug molecules. In this paper, we describe the derivation of two linear discriminant analysis (LDA) models for the prediction of passive blood-brain partitioning, expressed in terms of logBB values. The models are based on computationally derived physicochemical descriptors, namely the octanol/water partition coefficient (log P), the topological polar surface area (TPSA) and the total number of acidic and basic atoms, and were obtained using a homogeneous training set of 307 compounds, for all of which the published experimental logBB data had been determined in vivo. In particular, since molecules with logBB>0.3 cross the blood-brain barrier (BBB) readily while molecules with logBB=60 years were significantly less likely than those aged <50 years to engage in physical activity (OR=0.29, 95% CI=0.17, 0.49) and more likely to spend time sedentary (OR=2.77, 95% CI=1.53, 5.05). Similarly, obese individuals were less likely to be physically active (OR=0.34, 95% CI=0.17, 0.66) and they were suggestively more likely to be sedentary (OR=1.87, 95% CI=0.94, 3.71) than normal-weight individuals. Furthermore, current cigarette smokers were less physically active than those who formerly or never smoked (OR=0.47, 95% CI=0.28, 0.78). Conclusions - Physical activity promotion programs in urban China should target older people, obese individuals, and cigarette smokers, as these population subgroups exhibited low levels of physical activity. JF - American Journal of Preventive Medicine AU - Peters, Tricia M AU - Moore, Steven C AU - Xiang, Yong Bing AU - Yang, Gong AU - Shu, Xiao Ou AU - Ekelund, Ulf AU - Ji, Bu-Tian AU - Tan, Yu Ting AU - Liu, da Ke AU - Schatzkin, Arthur AU - Zheng, Wei AU - Chow, Wong Ho AU - Matthews, Charles E AU - Leitzmann, Michael F AD - National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland, Michael.Leitzmann@klinik.uni-regensburg.de Michael.Leitzmann@klinik.uni-regensburg.de Michael.Leitzmann@klinik.uni-regensburg.de Michael.Leitzmann@klinik.uni-regensburg.de Michael.Leitzmann@klinik.uni-regensburg.de Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 583 EP - 591 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 38 IS - 6 SN - 0749-3797, 0749-3797 KW - Physical Education Index KW - Adults KW - Exercise KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754869483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Accelerometer-Measured+Physical+Activity+in+Chinese+Adults&rft.au=Peters%2C+Tricia+M%3BMoore%2C+Steven+C%3BXiang%2C+Yong+Bing%3BYang%2C+Gong%3BShu%2C+Xiao+Ou%3BEkelund%2C+Ulf%3BJi%2C+Bu-Tian%3BTan%2C+Yu+Ting%3BLiu%2C+da+Ke%3BSchatzkin%2C+Arthur%3BZheng%2C+Wei%3BChow%2C+Wong+Ho%3BMatthews%2C+Charles+E%3BLeitzmann%2C+Michael+F&rft.aulast=Peters&rft.aufirst=Tricia&rft.date=2010-06-01&rft.volume=38&rft.issue=6&rft.spage=583&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2010.02.012 LA - English DB - Physical Education Index N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Exercise DO - http://dx.doi.org/10.1016/j.amepre.2010.02.012 ER - TY - JOUR T1 - Relative contribution of Panton-Valentine leukocidin to PMN plasma membrane permeability and lysis caused by USA300 and USA400 culture supernatants AN - 754869165; 13212226 AB - Panton-Valentine leukocidin (PVL) is a cytolytic toxin associated with severe community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections. However, the relative contribution of PVL to host cell lysis during CA-MRSA infection remains unknown. Here we investigated the relative contribution of PVL to human polymorphonuclear leukocyte (PMN) plasma membrane permeability and lysis in vitro by using culture supernatants from wild-type and isogenic lukS/F-PV negative (pvl) USA300 and USA400 strains. Using S. aureus culture conditions that favor selective high production of PVL (CCY medium), there was on average more PMN plasma membrane permeability and cell lysis caused by supernatants derived from wild-type strains compared with those from pvl strains. Unexpectedly, plasma membrane permeability did not necessarily correlate with ultimate cell lysis. Moreover, the level of pore formation caused by culture supernatants varied dramatically (e.g., range was 0.32-99.09% for wild-type USA300 supernatants at 30 min) and was not attributable to differences in PMN susceptibility to PVL among human blood donors. We conclude that PMN pore formation assays utilizing S. aureus culture supernatants have limited ability to estimate the relative contribution of PVL to pathogenesis (or cytolysis in vitro or in vivo), especially when assayed using culture media that promote selective high production of PVL. JF - Microbes and Infection AU - Graves, Shawna F AU - Kobayashi, Scott D AU - Braughton, Kevin R AU - Diep, Binh An AU - Chambers, Henry F AU - Otto, Michael AU - DeLeo, Frank R AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA, fdeleo@niaid.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 446 EP - 456 PB - Editions Scientifiques et Medicales Elsevier, 23 rue Linois 75724 Paris cedex 15 France VL - 12 IS - 6 SN - 1286-4579, 1286-4579 KW - Microbiology Abstracts B: Bacteriology KW - Blood donors KW - Leukocytes (polymorphonuclear) KW - Staphylococcus aureus KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754869165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbes+and+Infection&rft.atitle=Relative+contribution+of+Panton-Valentine+leukocidin+to+PMN+plasma+membrane+permeability+and+lysis+caused+by+USA300+and+USA400+culture+supernatants&rft.au=Graves%2C+Shawna+F%3BKobayashi%2C+Scott+D%3BBraughton%2C+Kevin+R%3BDiep%2C+Binh+An%3BChambers%2C+Henry+F%3BOtto%2C+Michael%3BDeLeo%2C+Frank+R&rft.aulast=Graves&rft.aufirst=Shawna&rft.date=2010-06-01&rft.volume=12&rft.issue=6&rft.spage=446&rft.isbn=&rft.btitle=&rft.title=Microbes+and+Infection&rft.issn=12864579&rft_id=info:doi/10.1016%2Fj.micinf.2010.02.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Leukocytes (polymorphonuclear); Staphylococcus aureus DO - http://dx.doi.org/10.1016/j.micinf.2010.02.005 ER - TY - JOUR T1 - Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier AN - 754868979; 13213045 AB - ATP-binding cassette (ABC) transporters are important selective elements of the blood-brain barrier. They line the luminal plasma membrane of the brain capillary endothelium, facing the vascular space, and both protect the central nervous system from entry of neurotoxicants and limit the access of therapeutic drugs to the brain parenchyma. Recent studies highlight the multiple signaling pathways through which the expression and activity of P-glycoprotein and other ABC transporters are modulated in response to xenobiotics, stress and disease. The results show that increased transporter expression occurs in response to signals that activate specific transcription factors, including pregnane-X receptor, constitutive androstane receptor, nuclear factor-[kappa]B and activator protein-1, and that reduced transporter activity occurs rapidly and reversibly in response to signaling through Src kinase, protein kinase C and estrogen receptors. A detailed understanding of such regulation can provide the basis for improved neuroprotection and enhanced therapeutic drug delivery to the brain. JF - Trends in Pharmacological Sciences AU - Miller, David S AD - Laboratory of Toxicology and Pharmacology, NIH/NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, miller@niehs.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 246 EP - 254 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 31 IS - 6 SN - 0165-6147, 0165-6147 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Protein kinase C KW - Parenchyma KW - Central nervous system KW - Drug delivery KW - ABC transporter KW - Blood-brain barrier KW - Activator protein 1 KW - Brain KW - Stress KW - Neuroprotection KW - Xenobiotics KW - P-Glycoprotein KW - Plasma membranes KW - Reviews KW - Transcription factors KW - Endothelium KW - Src protein KW - Estrogen receptors KW - Signal transduction KW - N3 11028:Neuropharmacology & toxicology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754868979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Pharmacological+Sciences&rft.atitle=Regulation+of+P-glycoprotein+and+other+ABC+drug+transporters+at+the+blood-brain+barrier&rft.au=Miller%2C+David+S&rft.aulast=Miller&rft.aufirst=David&rft.date=2010-06-01&rft.volume=31&rft.issue=6&rft.spage=246&rft.isbn=&rft.btitle=&rft.title=Trends+in+Pharmacological+Sciences&rft.issn=01656147&rft_id=info:doi/10.1016%2Fj.tips.2010.03.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Parenchyma; Protein kinase C; Drug delivery; Central nervous system; Blood-brain barrier; ABC transporter; Activator protein 1; Brain; Stress; Neuroprotection; Xenobiotics; P-Glycoprotein; Plasma membranes; Transcription factors; Reviews; Endothelium; Src protein; Estrogen receptors; Signal transduction DO - http://dx.doi.org/10.1016/j.tips.2010.03.003 ER - TY - JOUR T1 - Promises and Pitfalls of Emerging Measures of Physical Activity and the Environment AN - 754868900; 13210861 JF - American Journal of Preventive Medicine AU - Troiano, Richard P AU - Freedson, Patty S AD - Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, troianor@mail.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 682 EP - 683 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 38 IS - 6 SN - 0749-3797, 0749-3797 KW - Physical Education Index KW - Exercise KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754868900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Promises+and+Pitfalls+of+Emerging+Measures+of+Physical+Activity+and+the+Environment&rft.au=Troiano%2C+Richard+P%3BFreedson%2C+Patty+S&rft.aulast=Troiano&rft.aufirst=Richard&rft.date=2010-06-01&rft.volume=38&rft.issue=6&rft.spage=682&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2010.03.005 LA - English DB - Physical Education Index N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Exercise DO - http://dx.doi.org/10.1016/j.amepre.2010.03.005 ER - TY - JOUR T1 - Interventions for HIV and Hepatitis C Virus Infections in Recreational Drug Users AN - 754543844; 13267462 AB - Recreational drug use and infections are 2 of the major problems in the world today. Both cause serious health problems, such as immunologlc impairment leading to opportunistic infections and medical comorbldity, including medical complications associated with, for example, human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections. Effective and safe interventions (prevention and pharmacologic treatment) are possible for drug-dependent patients with single or dual infections with HIV and HCV if patients in drug treatment programs are closely monitored for adherence and compliance to treatment regimens. JF - Clinical Infectious Diseases AU - Khalsa, J H AU - Elkashef, A AD - Medical Consequences Branch, Div of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, 6001 Executive Blvd. Room 4137, MSC 9551, Bethesda, MD 20892, USA, jk98p@nih.aov A2 - Mayer, KH (ed) Y1 - 2010/06/01/ PY - 2010 DA - 2010 Jun 01 SP - 1505 EP - 1511 VL - 50 IS - 11 SN - 1058-4838, 1058-4838 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Compliance KW - Drug abuse KW - Opportunist infection KW - Hepatitis KW - health problems KW - Drug dependence KW - complications KW - Hepatitis C virus KW - Human immunodeficiency virus KW - Recreation areas KW - intervention KW - infection KW - prevention KW - Drugs KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754543844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Interventions+for+HIV+and+Hepatitis+C+Virus+Infections+in+Recreational+Drug+Users&rft.au=Khalsa%2C+J+H%3BElkashef%2C+A&rft.aulast=Khalsa&rft.aufirst=J&rft.date=2010-06-01&rft.volume=50&rft.issue=11&rft.spage=1505&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/10.1086%2F652447 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Drug dependence; Drug abuse; Drugs; Opportunist infection; health problems; Hepatitis; complications; Recreation areas; Human immunodeficiency virus; intervention; Compliance; prevention; infection; Hepatitis C virus DO - http://dx.doi.org/10.1086/652447 ER - TY - JOUR T1 - Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax AN - 754538164; 13251772 AB - Cholera toxin (CT) elicits a mucosal immune response in mice when used as a vaccine adjuvant. The mechanisms by which CT exerts its adjuvant effects are incompletely understood. We show that protection against inhalation anthrax by an irradiated spore vaccine depends on CT-mediated induction of IL-17-producing CD4 Th17 cells. Furthermore, IL-17 is involved in the induction of serum and mucosal antibody responses by CT. Th17 cells induced by CT have a unique cytokine profile compared with those induced by IL-6 and TGF-b, and their induction by CT requires cAMP-dependent secretion of IL-1b and b-calcitonin gene-related peptide by dendritic cells. These findings demonstrate that Th17 cells mediate mucosal adjuvant effects of CT and identify previously unexplored pathways involved in Th17 induction that could be targeted for development of unique mucosal adjuvants. JF - Proceedings of the National Academy of Sciences, USA AU - Datta, Sandip K AU - Sabet, Mojgan AU - Nguyen, Kim Phung L AU - Valdez, Patricia A AU - Gonzalez-Navajas, Jose M AU - Islam, Shamima AU - Mihajlov, Ivan AU - Fierer, Joshua AU - Insel, Paul A AU - Webster, Nicholas J AU - Guiney, Donald G AU - Raz, Eyal AD - Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, dattas@niaid.nih.gov. Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 10638 EP - 10643 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 107 IS - 23 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - IL-17 KW - dendritic cell KW - T cell KW - vaccine KW - cAMP KW - Inhalation KW - Interleukin 6 KW - Toxicants KW - Helper cells KW - Mucosa KW - Interleukin 1 KW - Disease control KW - Adjuvants KW - Dendritic cells KW - CD4 antigen KW - Cholera toxin KW - Interleukin 17 KW - Lymphocytes T KW - Transforming growth factor-b KW - Anthrax KW - Mucosal immunity KW - Pathogenic bacteria KW - Bacterial diseases KW - Immunity KW - Antibodies KW - Serum KW - Immune response KW - Vaccines KW - Spores KW - F 06905:Vaccines KW - Q1 08484:Species interactions: parasites and diseases KW - J 02350:Immunology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754538164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Mucosal+adjuvant+activity+of+cholera+toxin+requires+Th17+cells+and+protects+against+inhalation+anthrax&rft.au=Datta%2C+Sandip+K%3BSabet%2C+Mojgan%3BNguyen%2C+Kim+Phung+L%3BValdez%2C+Patricia+A%3BGonzalez-Navajas%2C+Jose+M%3BIslam%2C+Shamima%3BMihajlov%2C+Ivan%3BFierer%2C+Joshua%3BInsel%2C+Paul+A%3BWebster%2C+Nicholas+J%3BGuiney%2C+Donald+G%3BRaz%2C+Eyal&rft.aulast=Datta&rft.aufirst=Sandip&rft.date=2010-06-01&rft.volume=107&rft.issue=23&rft.spage=10638&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.1002348107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Antibodies; Pathogenic bacteria; Toxicants; Serum; Bacterial diseases; Disease control; Immunity; Vaccines; Interleukin 6; Inhalation; Mucosal immunity; Helper cells; Interleukin 1; Mucosa; Adjuvants; Dendritic cells; CD4 antigen; Cholera toxin; Interleukin 17; Lymphocytes T; Anthrax; Transforming growth factor-b; Immune response; Spores DO - http://dx.doi.org/10.1073/pnas.1002348107 ER - TY - JOUR T1 - Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection AN - 754537504; 13251841 AB - Olfactomedin 4 (OLFM4) is a glycoprotein that has been found to be up-regulated in inflammatory bowel diseases and Helicobacter pylori infected patients. However, its role in biological processes such as inflammation or other immune response is not known. In this study, we generated OLFM4 KO mice to investigate potential role(s) of OLFM4 in gastric mucosal responses to H. pylori infection. H. pylori colonization in the gastric mucosa of OLFM4 KO mice was significantly lower compared with WT littermates. The reduced bacterial load was associated with enhanced infiltration of inflammatory cells in gastric mucosa. Production and expression of proinflammatory cytokines/chemokines such as IL-1b, IL-5, IL-12 p70, and MIP-1a was increased in OLFM4 KO mice compared with infected controls. Furthermore, we found that OLFM4 is a target gene of NF--I[ordmB pathway and has a negative feedback effect on NF-I[ordmB activation induced by H. pylori infection through a direct association with nucleotide oligomerization domain-1 (NOD1) and -2 (NOD2). Together these observations indicate that OLFM4 exerts considerable influence on the host defense against H. pylori infection acting through NOD1 and NOD2 mediated NF-I[ordmB activation and subsequent cytokines and chemokines production, which in turn inhibit host immune response and contribute to persistence of H. pylori colonization. JF - Proceedings of the National Academy of Sciences, USA AU - Liu, Wenli AU - Yan, Ming AU - Liu, Yueqin AU - Wang, Ruihong AU - Li, Cuiling AU - Deng, Chuxia AU - Singh, Aparna AU - Coleman, William G AU - Rodgers, Griffin P AD - Molecular and Clinical Hematology Branch, National Heart, Lung and Blood Institute, and Edited by Harvey J. Alter, Warren G. Magnuson Clinical Center, Bethesda, MD, griffinr@extra.niddk.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 11056 EP - 11061 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 107 IS - 24 SN - 0027-8424, 0027-8424 KW - CSA Neurosciences Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Chemokines KW - Colonization KW - Cytokines KW - Feedback KW - Gastric mucosa KW - Glycoproteins KW - Immune response KW - Immunity KW - Infection KW - Inflammatory bowel diseases KW - Interleukin 1 KW - Interleukin 12 KW - Interleukin 5 KW - NOD2 protein KW - Nod1 protein KW - Nucleotides KW - Olfactomedin KW - Oligomerization KW - macrophage inflammatory protein 1 KW - Helicobacter pylori KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754537504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Olfactomedin+4+down-regulates+innate+immunity+against+Helicobacter+pylori+infection&rft.au=Liu%2C+Wenli%3BYan%2C+Ming%3BLiu%2C+Yueqin%3BWang%2C+Ruihong%3BLi%2C+Cuiling%3BDeng%2C+Chuxia%3BSingh%2C+Aparna%3BColeman%2C+William+G%3BRodgers%2C+Griffin+P&rft.aulast=Liu&rft.aufirst=Wenli&rft.date=2010-06-01&rft.volume=107&rft.issue=24&rft.spage=11056&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.1001269107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Chemokines; Interleukin 5; Gastric mucosa; Nod1 protein; NOD2 protein; macrophage inflammatory protein 1; Interleukin 1; Oligomerization; Immunity; Infection; Nucleotides; Interleukin 12; Colonization; Inflammatory bowel diseases; Cytokines; Feedback; Immune response; Glycoproteins; Olfactomedin; Helicobacter pylori DO - http://dx.doi.org/10.1073/pnas.1001269107 ER - TY - JOUR T1 - A Multiplex Calcium Assay for Identification of GPCR Agonists and Antagonists AN - 754536106; 13243182 AB - Activation of G sub(q) protein-coupled receptors can be monitored by measuring the increase in intracellular calcium with fluorescent dyes. Recent advances in fluorescent kinetic plate readers and liquid-handling technology have made it possible to follow these transient changes in intracellular calcium in a 1,536-well plate format for high-throughput screening (HTS). Here, we have applied the latest generation of fluorescence kinetic plate readers to multiplex the agonist and antagonist screens of a G protein-coupled receptor (GPCR). This multiplexed assay format provides an efficient and cost-effective method for HTS of G sub(q)-coupled GPCR targets. JF - Assay and Drug Development Technologies AU - Liu, K AU - Southall, N AU - Titus, SA AU - Inglese, J AU - Eskay, R L AU - Shinn, P AU - Austin, C P AU - Heilig, MA AU - Zheng, W AD - NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3370, USA, wzheng@mail.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 362 VL - 8 IS - 3 SN - 1540-658X, 1540-658X KW - Biotechnology and Bioengineering Abstracts KW - Fluorescence KW - G protein-coupled receptors KW - Kinetics KW - Fluorescent indicators KW - Drug development KW - high-throughput screening KW - Antagonists KW - Calcium (intracellular) KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754536106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Assay+and+Drug+Development+Technologies&rft.atitle=A+Multiplex+Calcium+Assay+for+Identification+of+GPCR+Agonists+and+Antagonists&rft.au=Liu%2C+K%3BSouthall%2C+N%3BTitus%2C+SA%3BInglese%2C+J%3BEskay%2C+R+L%3BShinn%2C+P%3BAustin%2C+C+P%3BHeilig%2C+MA%3BZheng%2C+W&rft.aulast=Liu&rft.aufirst=K&rft.date=2010-06-01&rft.volume=8&rft.issue=3&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Assay+and+Drug+Development+Technologies&rft.issn=1540658X&rft_id=info:doi/10.1089%2Fadt.2009.0245 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Fluorescence; G protein-coupled receptors; Kinetics; Fluorescent indicators; high-throughput screening; Drug development; Antagonists; Calcium (intracellular) DO - http://dx.doi.org/10.1089/adt.2009.0245 ER - TY - JOUR T1 - The role of mitochondria in the mammalian antiviral defense system AN - 754531971; 13211715 AB - Innate immunity is a crucial defense system against viral and bacterial pathogens, providing a rapid response to mitigate the effects of microbial attack. While more readily associated with respiration and metabolism, recent research has surprisingly identified a number of mitochondrial factors in the mammalian innate immune system. This review summarizes the novel mitochondrial proteins, such as MAVS and NLRX1, involved in this process and attempts to reconcile this new mitochondrial function with our previous knowledge of the organelle. JF - Mitochondrion AU - Scott, Iain AD - Molecular Biology Section, Translational Medicine Branch, National Heart Lung and Blood Institute, Building 10-CRC, Room 5-3216, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA, scotti@mail.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 316 EP - 320 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 10 IS - 4 SN - 1567-7249, 1567-7249 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Electron transport KW - Mitochondria KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754531971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mitochondrion&rft.atitle=The+role+of+mitochondria+in+the+mammalian+antiviral+defense+system&rft.au=Scott%2C+Iain&rft.aulast=Scott&rft.aufirst=Iain&rft.date=2010-06-01&rft.volume=10&rft.issue=4&rft.spage=316&rft.isbn=&rft.btitle=&rft.title=Mitochondrion&rft.issn=15677249&rft_id=info:doi/10.1016%2Fj.mito.2010.02.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Mitochondria DO - http://dx.doi.org/10.1016/j.mito.2010.02.005 ER - TY - JOUR T1 - Molecular and Clinical Responses in a Pilot Study of Gefitinib With Paclitaxel and Radiation in Locally Advanced Head-and-Neck Cancer AN - 754531328; 13210476 AB - Purpose - Epidermal growth factor receptor (EGFR) overexpression in head-and-neck squamous cell carcinoma (HNSCC) stimulates tumor cell proliferation, inhibits apoptosis, and increases chemotherapy and radiation resistance. We examined the toxicity, safety and the effects on EGFR signaling in tumor biopsy samples from patients with locally advanced HNSCC treated with the EGFR signaling inhibitor gefitinib (GEF) combined with weekly intravenous paclitaxel (PAC) and radiation therapy (RT). Methods and Materials - This was a pilot Phase I dose-escalation study. Eligibility included Stage III to IVB HNSCC, age >=18 years, no prior RT or chemotherapy, adequate organ function, and informed consent. Endpoints included determination of maximum tolerated dose (MTD) and analysis of treatment effect on EGFR signaling, tumor cell proliferation, and apoptosis in biopsy samples. Results - ten patients were treated. TheD of this combination was GEF 250 mg/d with 36 mg/m super(2) intravenously weekly x 6 with concurrent RT. Grade 3/4 toxicities included prolonged (>8 weeks) stomatitis (7 patients), infection (2 patients), and interstitial pneumonitis (1 patient). There were five complete responses (CR) and two partial responses (PR). Of 7 patients undergoing serial biopsies, only 1 patient demonstrated a reduction in phosphorylated EGFR, decreased downstream signaling, and reduced cellular proliferation after initiating GEF. Conclusions - Inhibition of EGFR by GEF was observed in only one of seven tumors studied. The addition of GEF to and RT did not appear to improve the response of locally advanced HNSCC compared with our prior experience with and RT alone. This treatment appeared to delay recovery from stomatitis. JF - International Journal of Radiation Oncology, Biology, Physics AU - Van Waes, Carter AU - Allen, Clint T AU - Citrin, Deborah AU - Gius, David AU - Colevas, ADimetrios AU - Harold, Nancy A AU - Rudy, Susan AU - Nottingham, Liesl AU - Muir, Christine AU - Chen, Zhong AU - Singh, Anurag K AU - Dancey, Janet AU - Morris, John C AD - Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda,, jmorris@mail.nih.gov jmorris@mail.nih.gov jmorris@mail.nih.gov jmorris@mail.nih.gov Y1 - 2010/06/01/ PY - 2010 DA - 2010 Jun 01 SP - 447 EP - 454 PB - Elsevier Science, Box 882 New York NY 10159 USA VL - 77 IS - 2 SN - 0360-3016, 0360-3016 KW - Toxicology Abstracts KW - Epidermal growth factor receptor KW - Head and neck cancer KW - Gefitinib KW - Paclitaxel KW - Radiation KW - Intravenous administration KW - Age KW - Apoptosis KW - Stomatitis KW - Chemotherapy KW - squamous cell carcinoma KW - Biopsy KW - Epidermal growth factor receptors KW - Tumors KW - Toxicity KW - Infection KW - Tumor cells KW - Pneumonitis KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754531328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics&rft.atitle=Molecular+and+Clinical+Responses+in+a+Pilot+Study+of+Gefitinib+With+Paclitaxel+and+Radiation+in+Locally+Advanced+Head-and-Neck+Cancer&rft.au=Van+Waes%2C+Carter%3BAllen%2C+Clint+T%3BCitrin%2C+Deborah%3BGius%2C+David%3BColevas%2C+ADimetrios%3BHarold%2C+Nancy+A%3BRudy%2C+Susan%3BNottingham%2C+Liesl%3BMuir%2C+Christine%3BChen%2C+Zhong%3BSingh%2C+Anurag+K%3BDancey%2C+Janet%3BMorris%2C+John+C&rft.aulast=Van+Waes&rft.aufirst=Carter&rft.date=2010-06-01&rft.volume=77&rft.issue=2&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics&rft.issn=03603016&rft_id=info:doi/10.1016%2Fj.ijrobp.2009.05.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Age; Intravenous administration; Apoptosis; Stomatitis; Chemotherapy; Epidermal growth factor receptors; Biopsy; squamous cell carcinoma; Toxicity; Tumors; Infection; Tumor cells; Paclitaxel; Pneumonitis; Gefitinib DO - http://dx.doi.org/10.1016/j.ijrobp.2009.05.037 ER - TY - JOUR T1 - Explanations of Risk in Families Without Identified Mutations for Hereditary Nonpolyposis Colorectal Cancer AN - 754141524; 201025067 AB - Purpose: Genetic testing for hereditary forms of cancer does not always identify a causative mutation. Little is known about personal or family response to these indeterminate results when a hereditary form of cancer is suspected. This study explored thoughts about and responses to risk for hereditary nonpolyposis colorectal cancer (HNPCC) when a family member has received indeterminate genetic test results. study, data were gathered from index cases who received indeterminate genetic test results through a longitudinal study offering genetic counseling and testing for HNPCC. First-degree relatives of these indeterminate index cases were also invited to participate in the qualitative interview.Methods: Semistructured telephone interviews were conducted with index cases and their at-risk first-degree relatives. Data were analyzed using the within- and across-case method. analysis led to the development of the Awareness and Surveillance Trajectory, which describes individual interpretations of and responses to risk, based on personal and family history. Explanations of risk addressed the meaning of cancer in the family and provided context for individual interpretations. They were identified using within-case analysis and organized into a typology: innate, exceptional, idiosyncratic, and undeveloped explanations.Conclusions: Members of families without identified HNPCC mutations vary in their explanations for, interpretations of, and responses to indeterminate genetic test results. Relevance: Explanations of family risk and interpretations of individual risk offer healthcare providers valuable information. In combination with the Awareness and Surveillance Trajectory, assessment of these beliefs can facilitate development of individualized recommendations and strategies for possible preventive actions. Adapted from the source document. JF - Journal of Nursing Scholarship AU - Ersig, Anne L AU - Ayres, Lioness AU - Hadley, Donald W AU - Koehly, Laura M AD - Gamma, Postdoctoral Fellow, College of Nursing, University of Iowa, Iowa City, IA and Social & Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 139 EP - 146 PB - Wiley-Blackwell, UK VL - 42 IS - 2 SN - 1527-6546, 1527-6546 KW - within- and across-case method hereditary non-polyposis colorectal cancer HNPCC genetic testing explanations and interpretations of risk KW - Risk assessment KW - Health care KW - Colorectal cancer KW - Relatives KW - Surveillance KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754141524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nursing+Scholarship&rft.atitle=Explanations+of+Risk+in+Families+Without+Identified+Mutations+for+Hereditary+Nonpolyposis+Colorectal+Cancer&rft.au=Ersig%2C+Anne+L%3BAyres%2C+Lioness%3BHadley%2C+Donald+W%3BKoehly%2C+Laura+M&rft.aulast=Ersig&rft.aufirst=Anne&rft.date=2010-06-01&rft.volume=42&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nursing+Scholarship&rft.issn=15276546&rft_id=info:doi/10.1111%2Fj.1547-5069.2010.01342.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Relatives; Cancer; Surveillance; Colorectal cancer; Health care; Risk assessment DO - http://dx.doi.org/10.1111/j.1547-5069.2010.01342.x ER - TY - JOUR T1 - Mental disorders as risk factors for substance use, abuse and dependence: results from the 10-year follow-up of the national comorbidity survey AN - 753833577; 3985930 AB - Aims The comorbidity of mental disorders and substance dependence is well documented, but prospective investigations in community samples are rare. This investigation examines the role of primary mental disorders as risk factors for the later onset of nicotine, alcohol and illicit drug use, abuse and dependence with abuse. Design The National Comorbidity Survey (NCS) was a nationally representative survey of mental and substance disorders in the United States carried out in 1990-92. The NCS-2 re-interviewed a probability subsample of NCS respondents in 2001-03, a decade after the baseline surveys. Particpants A total of 5001 NCS respondents were re-interviewed in the NCS-2 (87.6% of baseline sample). Results Aggregate analyses demonstrated significant prospective risks posed by baseline mental disorders for the onset of nicotine, alcohol and illicit drug dependence with abuse over the follow-up period. Particularly strong and consistent associations were observed for behavioral disorders and previous substance use conditions, as well as for certain mood and anxiety disorders. Conditional analyses demonstrated that many observed associations were limited to specific categories of use, abuse or dependence, including several mental disorders that were non-significant predictors in the aggregate analyses. Conclusions Many mental disorders are associated with an increased risk of later substance use conditions, but important differences in these associations are observed across the categories of use, abuse and dependence with abuse. These prospective findings have implications for the precision of prevention and treatment strategies targeting substance use disorders. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Swendsen, Joel AU - Conway, Kevin P AU - Degenhardt, Louisa AU - Glantz, Meyer AU - Jin, Robert AU - Merikangas, Kathleen R AU - Sampson, Nancy AU - Kessler, Ronald C AD - National Institute of Health, US ; University of New South Wales ; National Institutes of Health, US ; Harvard University ; National Institute of Mental Health, US Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 1117 EP - 1128 VL - 105 IS - 6 SN - 0965-2140, 0965-2140 KW - Sociology KW - Mental illness KW - Drug use KW - Drug users KW - Mental health KW - Surveys KW - Addiction KW - Drug abuse KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753833577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Mental+disorders+as+risk+factors+for+substance+use%2C+abuse+and+dependence%3A+results+from+the+10-year+follow-up+of+the+national+comorbidity+survey&rft.au=Swendsen%2C+Joel%3BConway%2C+Kevin+P%3BDegenhardt%2C+Louisa%3BGlantz%2C+Meyer%3BJin%2C+Robert%3BMerikangas%2C+Kathleen+R%3BSampson%2C+Nancy%3BKessler%2C+Ronald+C&rft.aulast=Swendsen&rft.aufirst=Joel&rft.date=2010-06-01&rft.volume=105&rft.issue=6&rft.spage=1117&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2010.02902.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12429; 3742 1121 11776 3753 3755; 3754 3755; 3753 3755; 3755; 7947 5772 7954; 7951 6220 7954; 561 6220 DO - http://dx.doi.org/10.1111/j.1360-0443.2010.02902.x ER - TY - JOUR T1 - Rapid, Simple, Quantitative, and Highly Sensitive Antibody Detection for Lyme Disease AN - 746305698; 13055764 AB - There is currently a need for improved serological tests for the diagnosis and monitoring of Lyme disease, an infection caused by Borrelia burgdorferi. In the present study, we evaluated luciferase immunoprecipitation systems (LIPSs) for use for profiling of the antibody responses to a panel of B. burgdorferi proteins for the diagnosis of Lyme disease. Initially, serum samples from a cohort of patients and controls (n = 46) were used for training and were profiled by the use of 15 different B. burgdorferi antigen constructs. For the patient sera, the antibody responses to several B. burgdorferi antigens, including VlsE, flagellin (FlaB), BmpA, DbpA, and DbpB, indicated that the antigens had high levels of immunoreactivity. However, the best diagnostic performance was achieved with a synthetic protein, designated VOVO, consisting of a repeated antigenic peptide sequence, VlsE-OspC-VlsE-OspC, Analysis of an independent set of serum samples (n = 139) used for validation showed that the VOVO LIPS test had 98% sensitivity (95% confidence interval [CI], 93% to 100%; P < 0.0001) and 100% specificity (95% CI, 94% to 100%; P < 0.0001). Similarly, the C6 peptide enzyme-linked immunosorbent assay (ELISA) also had 98% sensitivity (95% CI, 93% to 100%; P < 0.0001) and 98% specificity (95% CI, 90% to 100%; P < 0.0001). Receiver operating characteristic analysis revealed that the rates of detection of Lyme disease by the LIPS test and the C6 ELISA were not statistically different. However, the VOVO LIPS test displayed a wide dynamic range of antibody detection spanning over 10,000-fold without the need for serum dilution. These results suggest that screening by the LIPS test with VOVO and other B. burgdorferi antigens offers an efficient quantitative approach for evaluation of the antibody responses in patients with Lyme disease. JF - Clinical and Vaccine Immunology AU - Burbelo, Peter D AU - Issa, Alexandra T AU - Ching, Kathryn H AU - Cohen, Jeffrey I AU - Iadarola, Michael J AU - Marques, Adriana AD - Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, burbelop@nidcr.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 904 EP - 909 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 17 IS - 6 SN - 1556-679X, 1556-679X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Antibodies KW - Enzyme-linked immunosorbent assay KW - Borrelia burgdorferi KW - Immunoreactivity KW - Immunoprecipitation KW - Borrelia KW - Infection KW - Serological tests KW - Flagellin KW - Lyme disease KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746305698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Rapid%2C+Simple%2C+Quantitative%2C+and+Highly+Sensitive+Antibody+Detection+for+Lyme+Disease&rft.au=Burbelo%2C+Peter+D%3BIssa%2C+Alexandra+T%3BChing%2C+Kathryn+H%3BCohen%2C+Jeffrey+I%3BIadarola%2C+Michael+J%3BMarques%2C+Adriana&rft.aulast=Burbelo&rft.aufirst=Peter&rft.date=2010-06-01&rft.volume=17&rft.issue=6&rft.spage=904&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00476-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 30 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Antibodies; Immunoreactivity; Immunoprecipitation; Serological tests; Infection; Flagellin; Lyme disease; Borrelia burgdorferi; Borrelia DO - http://dx.doi.org/10.1128/CVI.00476-09 ER - TY - JOUR T1 - The influence of smokers' degree of dependence on the effectiveness of message framing for capturing smokers for a Quitline AN - 746164899; 12980511 AB - Smoking is a worldwide public health problem, and various communication strategies aimed at its cessation have been used. The objective of this paper was to explore differences over time of two communication strategies (gain-framed versus loss-framed) in encouraging calls to a Quitline, according to smoker's degree of dependence. A study was conducted for four weeks among passengers of two selected subway stations in the city of Rio de Janeiro-Brazil (N sub(average) = 12,500 passengers a day per station). The interventions - large posters with images and text based on central theme "shortness-of-breath" - also contained the Quitline number. Call rate differences between the strategies, overall and specific per study week, were calculated. Light smokers exposed to the positive-content message called on average 2.2 times more often than those exposed to the negative-content message (p < 0.001). The absolute difference in call rates decreased after the first week of the study (p for the additive interaction between intervention and study week, 0.02). For heavy smokers, no differences between the two stations were observed. Additive interaction was found between type of smoker - light or heavy - and intervention (p = 0.02). The results suggest that short-term positive-content campaigns based on issues pertaining to individuals' daily routine could be effective in capturing light smokers. These results may have considerable public health impact, as the prevalence of less dependent smokers is much higher than that of heavier smokers. JF - Addictive Behaviors AU - Szklo, Andre Salem AU - Coutinho, Evandro Silva Freire AD - Division of Epidemiology, Prevention and Surveillance Section, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil, aszklo@inca.gov.bresfcoutinho@ensp.fiocruz.br Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 620 EP - 624 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 35 IS - 6 SN - 0306-4603, 0306-4603 KW - Risk Abstracts KW - Smoking cessation KW - Persuasive communication KW - Risk assessment KW - Hotlines KW - Smoking KW - Communications KW - intervention KW - Additives KW - Public health KW - Urban areas KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746164899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+Behaviors&rft.atitle=The+influence+of+smokers%27+degree+of+dependence+on+the+effectiveness+of+message+framing+for+capturing+smokers+for+a+Quitline&rft.au=Szklo%2C+Andre+Salem%3BCoutinho%2C+Evandro+Silva+Freire&rft.aulast=Szklo&rft.aufirst=Andre&rft.date=2010-06-01&rft.volume=35&rft.issue=6&rft.spage=620&rft.isbn=&rft.btitle=&rft.title=Addictive+Behaviors&rft.issn=03064603&rft_id=info:doi/10.1016%2Fj.addbeh.2010.01.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Smoking; Communications; intervention; Additives; Urban areas; Public health DO - http://dx.doi.org/10.1016/j.addbeh.2010.01.007 ER - TY - JOUR T1 - Interleukin-27, an Anti-HIV-1 Cytokine, Inhibits Replication of Hepatitis C Virus AN - 746161729; 13182903 AB - Interleukin (IL)-27 is a member of IL-12 family cytokine. We have previously reported that IL-27 inhibits human immunodeficiency virus type-1 (HIV-1) replication in CD4 super(+) T cells and monocyte-derived macrophages, even though IL-12 enhances HTV-1 replication in primary CD4 super(+) T cells. Further study demonstrates that IL-27 induces antiviral genes including RNA-dependent protein kinase, oligoadenylate synthetase, and myxovirus protein in the same manner as interferon (IFN)-a. Neutralization assay using anti-IFN antibodies, real-time RT-PCR, and enzyme-linked immunosorbent assay demonstrated that IL-27 induces the antiviral genes without the induction of IFNs. IFN-a has been administered to hepatitis C virus (HCV)-infected patients as well as HCV/HTV-1 co-infected patients. Despite the improved immunotherapy, some patients are still failed to respond to the treatment. Since IL-27 induces IFN-a-like responses including the induction of antiviral genes, it was speculated that IL-27 may impact the replication of HCV. In this study, we evaluated the role of IL-27 on HCV replication using Huh7.5, an HCV permissive cell line. IL-27 induces STAT-1 and -3 in the cell line, and dose-dependently inhibited HCV. These data suggest that IL-27 may play a role in the development of a novel immunotherapeutic strategy for HCV and HCV/HIV co-infection. JF - Journal of Interferon & Cytokine Research AU - Frank, A C AU - Zhang, X AU - Katsounas, A AU - Bharucha, J P AU - Kottilil, S AU - Imamichi, T AD - Building 550, Room 126, Laboratory of Human Retrovirology, SAIC-Frederick Inc., NCI-Frederick, P.O. Box B, Frederick, MD, 21702, USA, timamichi@mail.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 427 EP - 431 VL - 30 IS - 6 SN - 1079-9907, 1079-9907 KW - Immunology Abstracts; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Macrophages KW - Enzyme-linked immunosorbent assay KW - Data processing KW - Permissive cells KW - Replication KW - Immunotherapy KW - Interferon KW - Interleukin 12 KW - CD4 antigen KW - Antibodies KW - Hepatitis C virus KW - Antiviral agents KW - Stat1 protein KW - Human immunodeficiency virus 1 KW - Interleukin 27 KW - Lymphocytes T KW - Polymerase chain reaction KW - Protein kinase KW - Monocytes KW - a-Interferon KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746161729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interferon+%26+Cytokine+Research&rft.atitle=Interleukin-27%2C+an+Anti-HIV-1+Cytokine%2C+Inhibits+Replication+of+Hepatitis+C+Virus&rft.au=Frank%2C+A+C%3BZhang%2C+X%3BKatsounas%2C+A%3BBharucha%2C+J+P%3BKottilil%2C+S%3BImamichi%2C+T&rft.aulast=Frank&rft.aufirst=A&rft.date=2010-06-01&rft.volume=30&rft.issue=6&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interferon+%26+Cytokine+Research&rft.issn=10799907&rft_id=info:doi/10.1089%2Fjir.2009.0093 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Macrophages; Enzyme-linked immunosorbent assay; Data processing; Replication; Permissive cells; Immunotherapy; Interleukin 12; Interferon; Antibodies; CD4 antigen; Antiviral agents; Stat1 protein; Interleukin 27; Lymphocytes T; Protein kinase; Polymerase chain reaction; Monocytes; a-Interferon; Hepatitis C virus; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1089/jir.2009.0093 ER - TY - JOUR T1 - Chronic imipramine but not bupropion increases arachidonic acid signaling in rat brain: is this related to 'switching' in bipolar disorder? AN - 746160644; 13111637 AB - Agents effective against mania in bipolar disorder are reported to decrease turnover of arachidonic acid (AA) in phospholipids and expression of calcium-dependent AA-selective cytosolic phospholipase A sub(2) (cPLA sub(2)) in rat brain. In contrast, fluoxetine, an antidepressant that is reported to switch bipolar depressed patients to mania, increases cPLA sub(2) expression and AA turnover in rat brain. We therefore hypothesized that antidepressants that increase switching to mania generally increase cPLA sub(2) and AA turnover in brain. To test this hypothesis, adult male CDF-344 rats were administered imipramine and bupropion, with reported high and low switching rates, respectively, at daily doses of 10 and 30mgkg super(-1) i.p., respectively, or i.p. saline (control) for 21 days. Frontal cortex expression of different PLA sub(2) enzymes and AA turnover rates in brain when the rats were unanesthetized were measured. Compared with chronic saline, chronic imipramine but not bupropion significantly increased cortex cPLA sub(2) mRNA activity, protein and phosphorylation, expression of the cPLA sub(2) transcription factor, activator protein-2a (AP-2a) and AA turnover in phospholipids. Protein levels of secretory phospholipase A sub(2), calcium-independent phospholipase A sub(2), cyclooxygenase (COX)-1 and COX-2 were unchanged, and prostaglandin E sub(2) was unaffected. These results, taken with prior data on chronic fluoxetine in rats, suggest that antidepressants that increase the switching tendency of bipolar depressed patients to mania do so by increasing AA recycling and metabolism in brain. Mania in bipolar disorder thus may involve upregulated brain AA metabolism. JF - Molecular Psychiatry AU - Lee, H-J AU - Rao, J S AU - Chang, L AU - Rapoport, S I AU - Kim, H-W AD - Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 602 EP - 614 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 15 IS - 6 SN - 1359-4184, 1359-4184 KW - Toxicology Abstracts; CSA Neurosciences Abstracts; Calcium & Calcified Tissue Abstracts KW - Cyclooxygenase-2 KW - bupropion KW - Depression KW - Calcium KW - Data processing KW - Phospholipase A2 KW - Affective disorders KW - Brain KW - Cortex (frontal) KW - Arachidonic acid KW - Enzymes KW - Prostaglandin E2 KW - Recycling KW - Fluoxetine KW - Antidepressants KW - imipramine KW - Phosphorylation KW - Bipolar disorder KW - Transcription factors KW - Metabolism KW - Phospholipids KW - Signal transduction KW - T 2000:Cellular Calcium KW - X 24310:Pharmaceuticals KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746160644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Psychiatry&rft.atitle=Chronic+imipramine+but+not+bupropion+increases+arachidonic+acid+signaling+in+rat+brain%3A+is+this+related+to+%27switching%27+in+bipolar+disorder%3F&rft.au=Lee%2C+H-J%3BRao%2C+J+S%3BChang%2C+L%3BRapoport%2C+S+I%3BKim%2C+H-W&rft.aulast=Lee&rft.aufirst=H-J&rft.date=2010-06-01&rft.volume=15&rft.issue=6&rft.spage=602&rft.isbn=&rft.btitle=&rft.title=Molecular+Psychiatry&rft.issn=13594184&rft_id=info:doi/10.1038%2Fmp.2008.117 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Cyclooxygenase-2; bupropion; Data processing; Calcium; Depression; Phospholipase A2; Affective disorders; Brain; Enzymes; Arachidonic acid; Cortex (frontal); Prostaglandin E2; Recycling; Fluoxetine; Antidepressants; Phosphorylation; imipramine; Bipolar disorder; Transcription factors; Metabolism; Signal transduction; Phospholipids DO - http://dx.doi.org/10.1038/mp.2008.117 ER - TY - JOUR T1 - Feline leukemia virus integrase and capsid packaging functions do not change the insertion profile of standard Moloney retroviral vectors AN - 746158793; 13112804 AB - Adverse events linked to perturbations of cellular genes by vector insertion reported in gene therapy trials and animal models have prompted attempts to better understand the mechanisms directing viral vector integration. The integration profiles of vectors based on MLV, ASLV, SIV and HIV have all been shown to be non-random, and novel vectors with a safer integration pattern have been sought. Recently, we developed a producer cell line called CatPac that packages standard MoMLV vectors with feline leukemia virus (FeLV) gag, pol and env gene products. We now report the integration profile of this vector, asking if the FeLV integrase and capsid proteins could modify the MoMLV integration profile, potentially resulting in a less genotoxic pattern. We transduced rhesus macaque CD34+ hematopoietic progenitor cells with CatPac or standard MoMLV vectors, and determined their integration profile by LAM-PCR. We obtained 184 and 175 unique integration sites (ISs) respectively for CatPac and standard MoMLV vectors, and these were compared with 10000 in silico-generated random IS. The integration profile for CatPac vector was similar to MoMLV and equally non-random, with a propensity for integration near transcription start sites and in highly dense gene regions. We found an IS for CatPac vector localized 715 nucleotides upstream of LMO-2, the gene involved in the acute lymphoblastic leukemia developed by X-SCID patients treated by gene therapy using MoMLV vectors. In conclusion, we found that replacement of MoMLV env, gag and pol gene products with FeLV did not alter the basic integration profile. Thus, there appears to be no safety advantage for this packaging system. However, considering the stability and efficacy of CatPac vectors, further development is warranted, using potentially safer vector backbones, for instance those with a SIN configuration. JF - Gene Therapy AU - Metais, J-Y AU - Topp, S AU - Doty, R T AU - Borate, B AU - Nguyen, A-D AU - Wolfsberg, T G AU - Abkowitz, J L AU - Dunbar, C E AD - Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 799 EP - 804 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 17 IS - 6 SN - 0969-7128, 0969-7128 KW - Genetics Abstracts; Virology & AIDS Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Animal models KW - Env protein KW - Feline leukemia KW - Clinical trials KW - Expression vectors KW - Integration KW - Stem cells KW - Acute lymphatic leukemia KW - Macaca mulatta KW - Packaging KW - Integrase KW - Capsids KW - Gene therapy KW - Producer cells KW - Genotoxicity KW - pol gene KW - Feline leukemia virus KW - Transcription KW - CD34 antigen KW - Gag protein KW - Nucleotides KW - Human immunodeficiency virus KW - Insertion KW - Hemopoiesis KW - Simian immunodeficiency virus KW - Capsid protein KW - W 30905:Medical Applications KW - V 22360:AIDS and HIV KW - G 07730:Development & Cell Cycle KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746158793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Feline+leukemia+virus+integrase+and+capsid+packaging+functions+do+not+change+the+insertion+profile+of+standard+Moloney+retroviral+vectors&rft.au=Metais%2C+J-Y%3BTopp%2C+S%3BDoty%2C+R+T%3BBorate%2C+B%3BNguyen%2C+A-D%3BWolfsberg%2C+T+G%3BAbkowitz%2C+J+L%3BDunbar%2C+C+E&rft.aulast=Metais&rft.aufirst=J-Y&rft.date=2010-06-01&rft.volume=17&rft.issue=6&rft.spage=799&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2010.24 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Capsids; Gene therapy; Producer cells; Genotoxicity; pol gene; Animal models; Transcription; Env protein; CD34 antigen; Feline leukemia; Clinical trials; Nucleotides; Gag protein; Expression vectors; Integration; Stem cells; Insertion; Acute lymphatic leukemia; Hemopoiesis; Capsid protein; Integrase; Packaging; Human immunodeficiency virus; Feline leukemia virus; Macaca mulatta; Simian immunodeficiency virus DO - http://dx.doi.org/10.1038/gt.2010.24 ER - TY - JOUR T1 - Inhibition of Xenotropic Murine Leukemia Virus-Related Virus by APOBEC3 Proteins and Antiviral Drugs AN - 746154837; 12845548 AB - Xenotropic murine leukemia virus-related virus (XMRV), a gammaretrovirus, has been isolated from human prostate cancer tissue and from activated CD4+ T cells and B cells of patients with chronic fatigue syndrome, suggesting an association between XMRV infection and these two diseases. Since APOBEC3G (A3G) and APOBEC3F (A3F), which are potent inhibitors of murine leukemia virus and Vif-deficient human immunodeficiency virus type 1 (HIV-1), are expressed in human CD4+ T cells and B cells, we sought to determine how XMRV evades suppression of replication by APOBEC3 proteins. We found that expression of A3G, A3F, or murine A3 in virus-producing cells resulted in their virion incorporation, inhibition of XMRV replication, and G-to-A hypermutation of the viral DNA with all three APOBEC3 proteins. Quantitation of A3G and A3F mRNAs indicated that, compared to the human T-cell lines CEM and H9, prostate cell lines LNCaP and DU145 exhibited 50% lower A3F mRNA levels, whereas A3G expression in 22Rv1, LNCaP, and DU145 cells was nearly undetectable. XMRV proviral genomes in LNCaP and DU145 cells were hypermutated at low frequency with mutation patterns consistent with A3F activity. XMRV proviral genomes were extensively hypermutated upon replication in A3G/A3F-positive T cells (CEM and H9), but not in A3G/A3F-negative cells (CEM-SS). We also observed that XMRV replication was susceptible to the nucleoside reverse transcriptase (RT) inhibitors zidovudine (AZT) and tenofovir and the integrase inhibitor raltegravir. In summary, the establishment of XMRV infection in patients may be dependent on infection of A3G/A3F-deficient cells, and cells expressing low levels of A3G/A3F, such as prostate cancer cells, may be ideal producers of infectious XMRV. Furthermore, the anti-HIV-1 drugs AZT, tenofovir, and raltegravir may be useful for treatment of XMRV infection. JF - Journal of Virology AU - Paprotka, Tobias AU - Venkatachari, Narasimhan J AU - Chaipan, Chawaree AU - Burdick, Ryan AU - Delviks-Frankenberry, Krista A AU - Hu, Wei-Shau AU - Pathak, Vinay K AD - Viral Mutation Section, vinay.pathak@nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 5719 EP - 5729 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 84 IS - 11 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Virions KW - Genomes KW - Lymphocytes B KW - Replication KW - Zidovudine KW - tenofovir KW - Infection KW - Murine leukemia virus KW - CD4 antigen KW - Prostate cancer KW - Antiviral agents KW - Human immunodeficiency virus 1 KW - nucleosides KW - Chronic infection KW - Lymphocytes T KW - DNA KW - RNA-directed DNA polymerase KW - chronic fatigue syndrome KW - Quantitation KW - Mutation KW - Xenotropic KW - Integrase KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746154837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Inhibition+of+Xenotropic+Murine+Leukemia+Virus-Related+Virus+by+APOBEC3+Proteins+and+Antiviral+Drugs&rft.au=Paprotka%2C+Tobias%3BVenkatachari%2C+Narasimhan+J%3BChaipan%2C+Chawaree%3BBurdick%2C+Ryan%3BDelviks-Frankenberry%2C+Krista+A%3BHu%2C+Wei-Shau%3BPathak%2C+Vinay+K&rft.aulast=Paprotka&rft.aufirst=Tobias&rft.date=2010-06-01&rft.volume=84&rft.issue=11&rft.spage=5719&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.00134-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 69 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Genomes; Virions; Replication; Lymphocytes B; Zidovudine; tenofovir; Infection; CD4 antigen; Prostate cancer; Antiviral agents; Chronic infection; nucleosides; DNA; Lymphocytes T; RNA-directed DNA polymerase; chronic fatigue syndrome; Mutation; Quantitation; Xenotropic; Integrase; Human immunodeficiency virus 1; Murine leukemia virus DO - http://dx.doi.org/10.1128/JVI.00134-10 ER - TY - JOUR T1 - Two-Step In Vivo Tumor Targeting by Biotin-Conjugated Antibodies and Superparamagnetic Nanoparticles Assessed by Magnetic Resonance Imaging at 1.5T AN - 746146846; 12851507 AB - Purpose: The purpose of this study was to assess two-step in vivo tumor targeting by specific biotin-conjugated antibodies and ultrasmall superparamagnetic iron oxide (USPIO)-anti-biotin nanoparticles as contrast agents for magnetic resonance imaging (MRI) at 1.5T. Procedures: D430B human lymphoma cells, expressing the CD70 surface antigen, were injected either s.c. or i.v. to induce pseudo-metastases in NOD/SCID mice. Thirty micrograms of biotin-conjugated monoclonal anti-CD70 was injected i.v., followed 4h later by 8 mu mol Fe/Kg USPIO-anti-biotin. After 24h, MRI was performed on T2* and b-FFE sequences. Signal intensity (SI) was calculated before and after USPIO-anti-biotin administration. Results: Subcutaneous xenografts showed a dishomogeneous 30% decrease in SI on T2* with anti-CD70+USPIO-anti-biotin treatment. Pseudo-metastatic xenografts showed a slight reduction in SI on T2*, but a 60% decrease in SI on b-FFE-weighted sequences. Prussian blue staining confirmed the presence of iron nanoparticles in the excised tumors. Conclusion: MRI at 1.5T can detect tumors by a two-step in vivo biotin-based protocol, which may allow the targeting of any cell surface antigen. JF - Molecular Imaging and Biology AU - Baio, Gabriella AU - Fabbi, Marina AU - Salvi, Sandra AU - Totero, Daniela AU - Truini, Mauro AU - Ferrini, Silvano AU - Neumaier, Carlo Emanuele AD - Department of Diagnostic Imaging, IST, National Cancer Institute, Largo Rosanna Benzi 10, 16132, Genoa, Italy, carlo.neumaier@istge.it Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 305 EP - 315 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 12 IS - 3 SN - 1536-1632, 1536-1632 KW - Biotechnology and Bioengineering Abstracts KW - Cell surface KW - iron oxides KW - Magnetic resonance imaging KW - Tumors KW - Antibodies KW - surface antigens KW - Contrast media KW - Xenografts KW - nanoparticles KW - Iron KW - Lymphoma KW - CD70 antigen KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746146846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Imaging+and+Biology&rft.atitle=Two-Step+In+Vivo+Tumor+Targeting+by+Biotin-Conjugated+Antibodies+and+Superparamagnetic+Nanoparticles+Assessed+by+Magnetic+Resonance+Imaging+at+1.5T&rft.au=Baio%2C+Gabriella%3BFabbi%2C+Marina%3BSalvi%2C+Sandra%3BTotero%2C+Daniela%3BTruini%2C+Mauro%3BFerrini%2C+Silvano%3BNeumaier%2C+Carlo+Emanuele&rft.aulast=Baio&rft.aufirst=Gabriella&rft.date=2010-06-01&rft.volume=12&rft.issue=3&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Molecular+Imaging+and+Biology&rft.issn=15361632&rft_id=info:doi/10.1007%2Fs11307-009-0264-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Cell surface; Antibodies; iron oxides; surface antigens; Magnetic resonance imaging; Contrast media; Xenografts; Tumors; Lymphoma; Iron; nanoparticles; CD70 antigen DO - http://dx.doi.org/10.1007/s11307-009-0264-6 ER - TY - JOUR T1 - Antisocial Behavioral Syndromes and Additional Psychiatric Comorbidity in Posttraumatic Stress Disorder Among U.S. Adults: Results From Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions AN - 746086673; 13132132 AB - BACKGROUND: Despite the relatively high prevalence of antisocial personality disorder (ASPD) in individuals with posttraumatic stress disorder (PTSD), associations of ASPD with clinical presentation of PTSD, including additional comorbidity, have not been investigated. OBJECTIVE: To present nationally representative findings on associations of DSM-IV ASPD versus syndromal adult antisocial behavior without conduct disorder before age 15 with additional psychiatric disorders among U.S. adults with PTSD. METHOD: Face-to-face interviews using the Alcohol Use Disorder and Associated Disabilities Interview Schedule- DSM-IV version in the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions (n = 34,653). RESULTS: After adjustment for sociodemographics and additional comorbidity, both antisocial syndromes were significantly associated with bipolar I, attention-deficit/hyperactivity, substance use, and paranoid, schizoid, histrionic, and obsessive-compulsive personality disorders among respondents with PTSD. Odds of major depressive and generalized anxiety disorders were significantly reduced among men with ASPD. CONCLUSIONS: Interventions targeting PTSD may require attention to co-occurring antisociality and additional comorbidity. JF - Journal of the American Psychiatric Nurses Association AU - Goldstein, Risee B AU - Compton, Wilson M AU - Grant, Bridget F AD - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA, goldster@mail.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 145 EP - 165 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 16 IS - 3 SN - 1078-3903, 1078-3903 KW - Health & Safety Science Abstracts KW - Age KW - disabilities KW - Psychology KW - personality KW - Morbidity KW - Medical personnel KW - intervention KW - Alcohol KW - posttraumatic stress disorder KW - substance use KW - USA KW - nursing KW - mental disorders KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746086673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Psychiatric+Nurses+Association&rft.atitle=Antisocial+Behavioral+Syndromes+and+Additional+Psychiatric+Comorbidity+in+Posttraumatic+Stress+Disorder+Among+U.S.+Adults%3A+Results+From+Wave+2+of+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions&rft.au=Goldstein%2C+Risee+B%3BCompton%2C+Wilson+M%3BGrant%2C+Bridget+F&rft.aulast=Goldstein&rft.aufirst=Risee&rft.date=2010-06-01&rft.volume=16&rft.issue=3&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Psychiatric+Nurses+Association&rft.issn=10783903&rft_id=info:doi/10.1177%2F1078390310370209 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Alcohol; Age; disabilities; posttraumatic stress disorder; Psychology; substance use; intervention; personality; mental disorders; nursing; Medical personnel; Morbidity; USA DO - http://dx.doi.org/10.1177/1078390310370209 ER - TY - JOUR T1 - Gravity sedimentation of granulocytapheresis concentrates with hydroxyethyl starch efficiently removes red blood cells and retains neutrophils AN - 746082683; 13060738 AB - BACKGROUND: Transfusion of granulocytapheresis concentrates can be limited by the volume of incompatible donor red blood cells (RBCs) in the component. Efficient reduction of RBCs in granulocyte units would result in safe transfusion of RBC-incompatible units.STUDY DESIGN AND METHODS: JF - Transfusion AU - Bryant, Barbara J AU - Yau, Yu Ying AU - Byrne, Phyllis J AU - Stroncek, David F AU - Leitman, Susan F AD - From the Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland. Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 1203 EP - 1209 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 50 IS - 6 SN - 0041-1132, 0041-1132 KW - Risk Abstracts; Immunology Abstracts KW - Leukocytes (granulocytic) KW - Erythrocytes KW - Leukocytes (neutrophilic) KW - transfusion KW - hydroxyethyl starch KW - Transfusion KW - Sedimentation KW - R2 23050:Environment KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746082683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Gravity+sedimentation+of+granulocytapheresis+concentrates+with+hydroxyethyl+starch+efficiently+removes+red+blood+cells+and+retains+neutrophils&rft.au=Bryant%2C+Barbara+J%3BYau%2C+Yu+Ying%3BByrne%2C+Phyllis+J%3BStroncek%2C+David+F%3BLeitman%2C+Susan+F&rft.aulast=Bryant&rft.aufirst=Barbara&rft.date=2010-06-01&rft.volume=50&rft.issue=6&rft.spage=1203&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2009.02576.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 22 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Leukocytes (granulocytic); Erythrocytes; Leukocytes (neutrophilic); hydroxyethyl starch; Sedimentation; Transfusion; transfusion DO - http://dx.doi.org/10.1111/j.1537-2995.2009.02576.x ER - TY - JOUR T1 - Prevalence of HLA antibodies in remotely transfused or alloexposed volunteer blood donors AN - 746082605; 13060748 AB - BACKGROUND: HLA antibody testing of previously transfused or pregnant donors may help reduce the risk of transfusion-related acute lung injury (TRALI). However, the prevalence of HLA antibodies in transfused donors has not been well characterized.STUDY DESIGN AND METHODS: JF - Transfusion AU - Kakaiya, Ram M AU - Triulzi, Darrell J AU - Wright, David J AU - Steele, Whitney R AU - Kleinman, Steven H AU - Busch, Michael P AU - Norris, Philip J AU - Hillyer, Christopher D AU - Gottschall, Jerome L AU - Rios, Jorge A AU - Carey, Patricia AU - Glynn, Simone A AD - From LifeSource, Glenview, Illinois; the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania; Westat, Inc., Rockville, Maryland; Blood Systems Research Institute/University of California at San Francisco, San Francisco, California; Emory University/Southern Region, American Red Cross Blood Services, Atlanta, Georgia; BloodCenter of Wisconsin, Milwaukee, Wisconsin; American Red Cross Blood Services, New England Region, Dedham, Massachusetts; Hoxworth Blood Center/University of Cincinnati Academic Health Center, Cincinnati, Ohio; and Transfusion Medicine & Cellular Therapy, National Heart, Lung, and Blood Institute, Bethesda, Maryland. Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 1328 EP - 1334 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 50 IS - 6 SN - 0041-1132, 0041-1132 KW - Immunology Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Histocompatibility antigen HLA KW - risk reduction KW - Blood donors KW - Antibodies KW - Injuries KW - Lung KW - blood donors KW - Pregnancy KW - H 13000:Medical Safety KW - R2 23060:Medical and environmental health KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746082605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Prevalence+of+HLA+antibodies+in+remotely+transfused+or+alloexposed+volunteer+blood+donors&rft.au=Kakaiya%2C+Ram+M%3BTriulzi%2C+Darrell+J%3BWright%2C+David+J%3BSteele%2C+Whitney+R%3BKleinman%2C+Steven+H%3BBusch%2C+Michael+P%3BNorris%2C+Philip+J%3BHillyer%2C+Christopher+D%3BGottschall%2C+Jerome+L%3BRios%2C+Jorge+A%3BCarey%2C+Patricia%3BGlynn%2C+Simone+A&rft.aulast=Kakaiya&rft.aufirst=Ram&rft.date=2010-06-01&rft.volume=50&rft.issue=6&rft.spage=1328&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2009.02556.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 13 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Blood donors; Antibodies; Injuries; Pregnancy; risk reduction; Lung; blood donors DO - http://dx.doi.org/10.1111/j.1537-2995.2009.02556.x ER - TY - JOUR T1 - Central Role of the Early Colonizer Veillonella sp. in Establishing Multispecies Biofilm Communities with Initial, Middle, and Late Colonizers of Enamel AN - 746082090; 13055793 AB - Human dental biofilm communities comprise several species, which can interact cooperatively or competitively. Bacterial interactions influence biofilm formation, metabolic changes, and physiological function of the community. Lactic acid, a common metabolite of oral bacteria, was measured in the flow cell effluent of one-, two- and three-species communities growing on saliva as the sole nutritional source. We investigated single-species and multispecies colonization by using known initial, early, middle, and late colonizers of enamel. Fluorescent-antibody staining and image analysis were used to quantify the biomass in saliva-fed flow cells. Of six species tested, only the initial colonizer Actinomyces oris exhibited significant growth. The initial colonizer Streptococcus oralis produced lactic acid but showed no significant growth. The early colonizer Veillonella sp. utilized lactic acid in two- and three-species biofilm communities. The biovolumes of all two-species biofilms increased when Veillonella sp. was present as one of the partners, indicating that this early colonizer promotes mutualistic community development. All three-species combinations exhibited enhanced growth except one, i.e., A. oris, Veillonella sp., and the middle colonizer Porphyromonas gingivalis, indicating specificity among three-species communities. Further specificity was seen when Fusobacterium nucleatum (a middle colonizer), Aggregatibacter actinomycetemcomitans (a late colonizer), and P. gingivalis did not grow with S. oralis in two-species biofilms, but inclusion of Veillonella sp. resulted in growth of all three-species combinations. We propose that commensal veillonellae use lactic acid for growth in saliva and that they communicate metabolically with initial, early, middle, and late colonizers to establish multispecies communities on enamel. JF - Journal of Bacteriology AU - Periasamy, Saravanan AU - Kolenbrander, Paul E AD - Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, pkolenbrander@dir.nidcr.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 2965 EP - 2972 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 192 IS - 12 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Calcium & Calcified Tissue Abstracts KW - Porphyromonas gingivalis KW - Commensals KW - Image processing KW - Metabolites KW - Effluents KW - Biomass KW - Fusobacterium nucleatum KW - Community development KW - Colonization KW - Veillonella KW - Lactic acid KW - Biofilms KW - Saliva KW - Actinomyces KW - Dental enamel KW - Streptococcus oralis KW - J 02430:Symbiosis, Antibiosis & Phages KW - T 2020:Nutrition and Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746082090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Central+Role+of+the+Early+Colonizer+Veillonella+sp.+in+Establishing+Multispecies+Biofilm+Communities+with+Initial%2C+Middle%2C+and+Late+Colonizers+of+Enamel&rft.au=Periasamy%2C+Saravanan%3BKolenbrander%2C+Paul+E&rft.aulast=Periasamy&rft.aufirst=Saravanan&rft.date=2010-06-01&rft.volume=192&rft.issue=12&rft.spage=2965&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01631-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 21 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Colonization; Commensals; Lactic acid; Image processing; Metabolites; Saliva; Biofilms; Biomass; Effluents; Dental enamel; Community development; Porphyromonas gingivalis; Veillonella; Fusobacterium nucleatum; Actinomyces; Streptococcus oralis DO - http://dx.doi.org/10.1128/JB.01631-09 ER - TY - JOUR T1 - Biological Characterization of Chlamydia trachomatis Plasticity Zone MACPF Domain Family Protein CT153 AN - 746077657; 12925883 AB - Chlamydia trachomatis strains are obligate intracellular human pathogens that share near genomic synteny but have distinct infection and disease organotropisms. The genetic basis for differences in the pathogen-host relationship among chlamydial strains is linked to a variable region of chlamydial genomes, termed the plasticity zone (PZ). Two groups of PZ-encoded proteins, the membrane attack complex/perforin (MACPF) domain protein (CT153) and members of the phospholipase D-like (PLD) family, are related to proteins that modify membranes and lipids, but the functions of CT153 and the PZ PLDs (pzPLDs) are unknown. Here, we show that full-length CT153 (p91) was present in the elementary bodies (EBs) of 15 C. trachomatis reference strains. CT153 underwent a rapid infection-dependent proteolytic cleavage into polypeptides of 57 and 41 kDa that was independent of de novo chlamydial protein synthesis. Following productive infection, p91 was expressed during the mid-developmental cycle and was similarly processed into p57 and p41 fragments. Infected-cell fractionation studies showed that insoluble fractions contained p91, p57, and p41, whereas only p91 was found in the soluble fraction, indicating that unprocessed CT153 may be secreted. Finally, CT153 localized to a distinct population of reticulate bodies, some of which were in contact with the inclusion membrane. JF - Infection and Immunity AU - Taylor, Lacey D AU - Nelson, David E AU - Dorward, David W AU - Whitmire, William M AU - Caldwell, Harlan D AD - Laboratory of Intracellular Parasites, hcaldwell@niaid.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 2691 EP - 2699 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 78 IS - 6 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Genomes KW - Infection KW - Lipids KW - Membrane attack complex KW - Membrane proteins KW - Organotropism KW - Pathogens KW - Perforin KW - Phospholipase D KW - Plasticity KW - Protein biosynthesis KW - Proteolysis KW - Reticulate bodies KW - Synteny KW - Variable region KW - genomics KW - Chlamydia trachomatis KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746077657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Biological+Characterization+of+Chlamydia+trachomatis+Plasticity+Zone+MACPF+Domain+Family+Protein+CT153&rft.au=Taylor%2C+Lacey+D%3BNelson%2C+David+E%3BDorward%2C+David+W%3BWhitmire%2C+William+M%3BCaldwell%2C+Harlan+D&rft.aulast=Taylor&rft.aufirst=Lacey&rft.date=2010-06-01&rft.volume=78&rft.issue=6&rft.spage=2691&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.01455-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 60 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Proteolysis; Genomes; Perforin; Synteny; Protein biosynthesis; Lipids; Phospholipase D; Membrane attack complex; Pathogens; Membrane proteins; Plasticity; Infection; Organotropism; genomics; Reticulate bodies; Variable region; Chlamydia trachomatis DO - http://dx.doi.org/10.1128/IAI.01455-09 ER - TY - JOUR T1 - Modulation of Allergic Airway Inflammation by the Oral Pathogen Porphyromonas gingivalis AN - 746077033; 12925867 AB - Accumulating evidence suggests that bacteria associated with periodontal disease may exert systemic immunomodulatory effects. Although the improvement in oral hygiene practices in recent decades correlates with the increased incidence of asthma in developed nations, it is not known whether diseases of the respiratory system might be influenced by the presence of oral pathogens. The present study sought to determine whether subcutaneous infection with the anaerobic oral pathogen Porphyromonas gingivalis exerts a regulatory effect on allergic airway inflammation. BALB/c mice sensitized and subsequently challenged with ovalbumin exhibited airway hyperresponsiveness to methacholine aerosol and increased airway inflammatory cell influx and Th2 cytokine (interleukin-4 [IL-4], IL-5, and IL-13) content relative to those in nonallergic controls. Airway inflammatory cell and cytokine contents were significantly reduced by establishment of a subcutaneous infection with P. gingivalis prior to allergen sensitization, whereas serum levels of ovalbumin-specific IgE and airway responsiveness were not altered. Conversely, subcutaneous infection initiated after allergen sensitization did not alter inflammatory end points but did reduce airway responsiveness in spite of increased serum IgE levels. These data provide the first direct evidence of a regulatory effect of an oral pathogen on allergic airway inflammation and responsiveness. Furthermore, a temporal importance of the establishment of infection relative to allergen sensitization is demonstrated for allergic outcomes. JF - Infection and Immunity AU - Card, Jeffrey W AU - Carey, Michelle A AU - Voltz, James W AU - Bradbury, JAlyce AU - Ferguson, Catherine D AU - Cohen, Eric A AU - Schwartz, Samuel AU - Flake, Gordon P AU - Morgan, Daniel L AU - Arbes Jr. Jr, Samuel J AD - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, zeldin@niehs.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 2488 EP - 2496 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 78 IS - 6 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Aerosols KW - Allergens KW - Asthma KW - Data processing KW - Helper cells KW - Immunoglobulin E KW - Immunomodulation KW - Infection KW - Inflammation KW - Interleukin 13 KW - Interleukin 4 KW - Interleukin 5 KW - Lymphocytes T KW - Oral hygiene KW - Ovalbumin KW - Pathogens KW - Periodontal diseases KW - Respiratory system KW - Respiratory tract KW - Respiratory tract diseases KW - Serum levels KW - methacholine KW - Porphyromonas gingivalis KW - A 01450:Environmental Pollution & Waste Treatment KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746077033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Modulation+of+Allergic+Airway+Inflammation+by+the+Oral+Pathogen+Porphyromonas+gingivalis&rft.au=Card%2C+Jeffrey+W%3BCarey%2C+Michelle+A%3BVoltz%2C+James+W%3BBradbury%2C+JAlyce%3BFerguson%2C+Catherine+D%3BCohen%2C+Eric+A%3BSchwartz%2C+Samuel%3BFlake%2C+Gordon+P%3BMorgan%2C+Daniel+L%3BArbes+Jr.+Jr%2C+Samuel+J&rft.aulast=Card&rft.aufirst=Jeffrey&rft.date=2010-06-01&rft.volume=78&rft.issue=6&rft.spage=2488&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.01270-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 38 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Ovalbumin; Interleukin 4; Aerosols; Interleukin 5; Data processing; Helper cells; Asthma; Pathogens; Infection; Immunomodulation; Inflammation; Serum levels; Periodontal diseases; Respiratory tract diseases; Interleukin 13; Oral hygiene; methacholine; Allergens; Immunoglobulin E; Lymphocytes T; Respiratory system; Respiratory tract; Porphyromonas gingivalis DO - http://dx.doi.org/10.1128/IAI.01270-09 ER - TY - JOUR T1 - Use of the Cre-lox Recombination System To Investigate the lp54 Gene Requirement in the Infectious Cycle of Borrelia burgdorferi AN - 746077007; 12925855 AB - Borrelia burgdorferi, the causative agent of Lyme disease, has a complex genome consisting of a linear chromosome and up to 21 linear and circular plasmids. These plasmids encode numerous proteins critical to the spirochete's infectious cycle and many hypothetical proteins whose functions and requirements are unknown. The conserved linear plasmid lp54 encodes several proteins important for survival in the mouse-tick infectious cycle, but the majority of the proteins are of unknown function and lack homologs outside the borreliae. In this study we adapted the Cre-lox recombination system to create large deletions in the B. burgdorferi genome. Using Cre-lox, we systematically investigated the contribution of 14 adjacent genes on the left arm of lp54 to the overall infectivity of B. burgdorferi. The deletion of the region of lp54 encompassing bba07 to bba14 had no significant effect on the infectious cycle of B. burgdorferi. The deletion of bba01 to bba07 resulted in a slight growth defect but did not significantly affect the ability of B. burgdorferi to complete the infectious cycle. This study demonstrated the utility of the Cre-lox system to efficiently explore gene requirements in B. burgdorferi and surprisingly revealed that a large number of the highly conserved proteins encoded on lp54 are not required to complete the infectious cycle. JF - Infection and Immunity AU - Bestor, Aaron AU - Stewart, Philip E AU - Jewett, Mollie W AU - Sarkar, Amit AU - Tilly, Kit AU - Rosa, Patricia A AD - Laboratory of Zoonotic Pathogens, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, bestora@niaid.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 2397 EP - 2407 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 78 IS - 6 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Chromosomes KW - Genomes KW - Infectivity KW - Lyme disease KW - Plasmids KW - Recombination KW - Survival KW - Borrelia burgdorferi KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746077007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Use+of+the+Cre-lox+Recombination+System+To+Investigate+the+lp54+Gene+Requirement+in+the+Infectious+Cycle+of+Borrelia+burgdorferi&rft.au=Bestor%2C+Aaron%3BStewart%2C+Philip+E%3BJewett%2C+Mollie+W%3BSarkar%2C+Amit%3BTilly%2C+Kit%3BRosa%2C+Patricia+A&rft.aulast=Bestor&rft.aufirst=Aaron&rft.date=2010-06-01&rft.volume=78&rft.issue=6&rft.spage=2397&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.01059-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 61 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Genomes; Recombination; Chromosomes; Infectivity; Survival; Plasmids; Lyme disease; Borrelia burgdorferi DO - http://dx.doi.org/10.1128/IAI.01059-09 ER - TY - JOUR T1 - Safety and Pharmacokinetics of Single Intravenous Dose of MGAWN1, a Novel Monoclonal Antibody to West Nile Virus AN - 746003000; 12923636 AB - West Nile Virus (WNV) is a neurotropic flavivirus that can cause debilitating diseases, such as encephalitis, meningitis, or flaccid paralysis. We report the safety, pharmacokinetics, and immunogenicity of a recombinant humanized monoclonal antibody (MGAWN1) targeting the E protein of WNV in a phase 1 study, the first to be performed on humans. A single intravenous infusion of saline or of MGAWN1 at escalating doses (0.3, 1, 3, 10, or 30 mg/kg of body weight) was administered to 40 healthy volunteers (30 receiving MGAWN1; 10 receiving placebo). Subjects were evaluated on days 0, 1, 3, 7, 14, 21, 28, 42, 56, 91, 120, and 180 by clinical assessments, clinical laboratory studies, electrocardiograms (ECGs), and pharmacokinetic and immunogenicity assays. All 40 subjects tolerated the infusion of the study drug, and 39 subjects completed the study. One serious adverse event of schizophrenia occurred in the 0.3-mg/kg cohort. One grade 3 neutropenia occurred in the 3-mg/kg cohort. Six MGAWN1-treated subjects experienced 11 drug-related adverse events, including diarrhea (1 subject), chest discomfort (1), oral herpes (1), rhinitis (1), neutropenia (2), leukopenia (1), dizziness (1), headache (2), and somnolence (1). In the 30-mg/kg cohort, MGAWN1 had a half-life of 26.7 days and a maximum concentration in serum (Cmax) of 953 kg/ml. This study suggests that single infusions of MGAWN1 up to 30 mg/kg appear to be safe and well tolerated in healthy subjects. The Cmax of 953 kg/ml exceeds the target level in serum estimated from hamster studies by 28-fold and should provide excess WNV neutralizing activity and penetration into the brain and cerebrospinal fluid (CSF). Further evaluation of MGAWN1 for the treatment of West Nile virus infections is warranted. JF - Antimicrobial Agents & Chemotherapy AU - Beigel, John H AU - Nordstrom, Jeffrey L AU - Pillemer, Stanley R AU - Roncal, Cory AU - Goldwater, DRonald AU - Li, Hua AU - Holland, PChris AU - Johnson, Syd AU - Stein, Kathryn AU - Koenig, Scott AD - MacroGenics Inc., Rockville, jbeigel@niaid.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 2431 EP - 2436 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 54 IS - 6 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Rhinitis KW - Chest KW - Infection KW - Herpes simplex KW - Flavivirus KW - Meningitis KW - Schizophrenia KW - Cerebrospinal fluid KW - Mental disorders KW - Body weight KW - Headache KW - Drugs KW - Intravenous administration KW - Diarrhea KW - Monoclonal antibodies KW - Brain KW - E protein KW - EKG KW - Pharmacokinetics KW - Encephalitis KW - Paralysis KW - Neutropenia KW - Immunogenicity KW - Leukopenia KW - West Nile virus KW - A 01340:Antibiotics & Antimicrobials KW - V 22350:Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746003000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Safety+and+Pharmacokinetics+of+Single+Intravenous+Dose+of+MGAWN1%2C+a+Novel+Monoclonal+Antibody+to+West+Nile+Virus&rft.au=Beigel%2C+John+H%3BNordstrom%2C+Jeffrey+L%3BPillemer%2C+Stanley+R%3BRoncal%2C+Cory%3BGoldwater%2C+DRonald%3BLi%2C+Hua%3BHolland%2C+PChris%3BJohnson%2C+Syd%3BStein%2C+Kathryn%3BKoenig%2C+Scott&rft.aulast=Beigel&rft.aufirst=John&rft.date=2010-06-01&rft.volume=54&rft.issue=6&rft.spage=2431&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.01178-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 22 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Intravenous administration; Diarrhea; Monoclonal antibodies; Brain; Rhinitis; Infection; Chest; Herpes simplex; E protein; Encephalitis; Pharmacokinetics; EKG; Meningitis; Paralysis; Schizophrenia; Neutropenia; Mental disorders; Cerebrospinal fluid; Body weight; Immunogenicity; Headache; Leukopenia; Drugs; West Nile virus; Flavivirus DO - http://dx.doi.org/10.1128/AAC.01178-09 ER - TY - JOUR T1 - Heteroresistance of Cryptococcus gattii to Fluconazole AN - 746002018; 12923625 AB - We analyzed 71 clinical and environmental Cryptococcus gattii strains that had been isolated before or after the advent of azole antifungals to determine their level of heteroresistance to fluconazole (LHF). All strains of C. gattii manifested heteroresistance, with LHFs that ranged between 4 kg/ml and 32 kg/ml. A considerably higher proportion of the C. gattii strains (86%) than Cryptococcus neoformans strains (46%) exhibited LHFs that were 16 kg/ml. No significant correlation was observed between the molecular type or serotypes of strains and their respective LHF. The strains which expressed a higher LHF were also more resistant to xenobiotics than the strains with a low LHF, and the level of resistance to xenobiotics was significantly higher than that reported for C. neoformans. The heteroresistant subpopulation, whose level of drug resistance had been raised in a stepwise manner to 64 kg/ml, reverted to the original LHF upon daily transfers in drug-free medium. Importantly, the strains with high LHFs were significantly more virulent than those with low LHFs. Since all the clinical isolates that had not been exposed to azole drugs as well as the environmental strains manifested heteroresistance to fluconazole, heteroresistance of C. gattii to azoles is an intrinsic mechanism as in C. neoformans and is associated with the strain's virulence. JF - Antimicrobial Agents & Chemotherapy AU - Varma, A AU - Kwon-Chung, K J AD - Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, June_kwon-chung@nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 2303 EP - 2311 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 54 IS - 6 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Clinical isolates KW - Virulence KW - fluconazole KW - Serotypes KW - Cryptococcus neoformans KW - Subpopulations KW - Drug resistance KW - Xenobiotics KW - Drugs KW - azoles KW - K 03340:Effects of Physical & Chemical Factors KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746002018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Heteroresistance+of+Cryptococcus+gattii+to+Fluconazole&rft.au=Varma%2C+A%3BKwon-Chung%2C+K+J&rft.aulast=Varma&rft.aufirst=A&rft.date=2010-06-01&rft.volume=54&rft.issue=6&rft.spage=2303&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00153-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Virulence; Clinical isolates; Serotypes; fluconazole; Drug resistance; Subpopulations; Xenobiotics; Drugs; azoles; Cryptococcus neoformans DO - http://dx.doi.org/10.1128/AAC.00153-10 ER - TY - JOUR T1 - Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families AN - 745938302; 13150954 AB - Small, hydrophobic proteins whose synthesis is repressed by small RNAs (sRNAs), denoted type I toxin-antitoxin modules, were first discovered on plasmids where they regulate plasmid stability, but were subsequently found on a few bacterial chromosomes. We used exhaustive PSI-BLAST and TBLASTN searches across 774 bacterial genomes to identify homologs of known type I toxins. These searches substantially expanded the collection of predicted type I toxins, revealed homology of the Ldr and Fst toxins, and suggested that type I toxin-antitoxin loci are not spread by horizontal gene transfer. To discover novel type I toxin-antitoxin systems, we developed a set of search parameters based on characteristics of known loci including the presence of tandem repeats and clusters of charged and bulky amino acids at the C-termini of short proteins containing predicted transmembrane regions. We detected sRNAs for three predicted toxins from enterohemorrhagic Escherichia coli and Bacillus subtilis, and showed that two of the respective proteins indeed are toxic when overexpressed. We also demonstrated that the local free-energy minima of RNA folding can be used to detect the positions of the sRNA genes. Our results suggest that type I toxin-antitoxin modules are much more widely distributed among bacteria than previously appreciated. JF - Nucleic Acids Research AU - Fozo, Elizabeth M AU - Makarova, Kira S AU - Shabalina, Svetlana A AU - Yutin, Natalya AU - Koonin, Eugene V AU - Storz, Gisela AD - super(1)Eunice Kennedy Shriver National Institute of Child Health and Human Development and super(2)National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894, USA Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 3743 EP - 3759 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 38 IS - 11 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Bacillus subtilis KW - Amino acids KW - Hydrophobicity KW - Plasmids KW - Toxins KW - Free energy KW - Chromosomes KW - RNA KW - Homology KW - Gene transfer KW - Escherichia coli KW - J 02310:Genetics & Taxonomy KW - W 30910:Imaging KW - A 01310:Products of Microorganisms KW - N 14830:RNA KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745938302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Abundance+of+type+I+toxin-antitoxin+systems+in+bacteria%3A+searches+for+new+candidates+and+discovery+of+novel+families&rft.au=Fozo%2C+Elizabeth+M%3BMakarova%2C+Kira+S%3BShabalina%2C+Svetlana+A%3BYutin%2C+Natalya%3BKoonin%2C+Eugene+V%3BStorz%2C+Gisela&rft.aulast=Fozo&rft.aufirst=Elizabeth&rft.date=2010-06-01&rft.volume=38&rft.issue=11&rft.spage=3743&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkq054 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Genomes; Chromosomes; Amino acids; Homology; RNA; Gene transfer; Hydrophobicity; Plasmids; Free energy; Toxins; Bacillus subtilis; Escherichia coli DO - http://dx.doi.org/10.1093/nar/gkq054 ER - TY - JOUR T1 - Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase AN - 745936575; 13139047 AB - Cancer cells have distinct metabolic needs that are different from normal cells and can be exploited for development of anti-cancer therapeutics. Activation of the tumor specific M2 form of pyruvate kinase (PKM2) is a potential strategy for returning cancer cells to a metabolic state characteristic of normal cells. Here, we describe activators of PKM2 based upon a substituted thieno[3,2-b]pyrrole[3,2-d]pyridazinone scaffold. The synthesis of these agents, structure-activity relationships, analysis of activity at related targets (PKM1, PKR and PKL) and examination of aqueous solubility are investigated. These agents represent the second reported chemotype for activation of PKM2. JF - Bioorganic and Medicinal Chemistry Letters AU - Jiang, Jian-Kang AU - Boxer, Matthew B AU - Heiden, Matthew GVander AU - Shen, Min AU - Skoumbourdis, Amanda P AU - Southall, Noel AU - Veith, Henrike AU - Leister, William AU - Austin, Christopher P AU - Park, Hee Won AU - Inglese, James AU - Cantley, Lewis C AU - Auld, Douglas S AU - Thomas, Craig J AD - NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA, craigt@nhgri.nih.gov craigt@nhgri.nih.gov craigt@nhgri.nih.gov craigt@nhgri.nih.gov craigt@nhgri.nih.gov Y1 - 2010/06/01/ PY - 2010 DA - 2010 Jun 01 SP - 3387 EP - 3393 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 20 IS - 11 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - Solubility KW - Drug development KW - Tumors KW - Tumor cells KW - Structure-activity relationships KW - Cancer KW - scaffolds KW - Pyruvate kinase KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745936575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Evaluation+of+thieno%5B3%2C2-b%5Dpyrrole%5B3%2C2-d%5Dpyridazinones+as+activators+of+the+tumor+cell+specific+M2+isoform+of+pyruvate+kinase&rft.au=Jiang%2C+Jian-Kang%3BBoxer%2C+Matthew+B%3BHeiden%2C+Matthew+GVander%3BShen%2C+Min%3BSkoumbourdis%2C+Amanda+P%3BSouthall%2C+Noel%3BVeith%2C+Henrike%3BLeister%2C+William%3BAustin%2C+Christopher+P%3BPark%2C+Hee+Won%3BInglese%2C+James%3BCantley%2C+Lewis+C%3BAuld%2C+Douglas+S%3BThomas%2C+Craig+J&rft.aulast=Jiang&rft.aufirst=Jian-Kang&rft.date=2010-06-01&rft.volume=20&rft.issue=11&rft.spage=3387&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2010.04.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Solubility; Drug development; Tumors; Structure-activity relationships; Tumor cells; scaffolds; Cancer; Pyruvate kinase DO - http://dx.doi.org/10.1016/j.bmcl.2010.04.015 ER - TY - JOUR T1 - Effects of low-field magnetic stimulation on brain glucose metabolism AN - 745636760; 13034482 AB - Echo planar imaging (EPI), the gold standard technique for functional MRI (fMRI), is based on fast magnetic field gradient switching. These time-varying magnetic fields induce electric (E) fields in the brain that could influence neuronal activity; but this has not been tested. Here we assessed the effects of EPI on brain glucose metabolism (marker of brain function) using PET and 18F 2-fluoro-2-deoxy-D-glucose ( super(18)FDG). Fifteen healthy subjects were in a 4 T magnet during the super(18)FDG uptake period twice: with (ON) and without (OFF) EPI gradients pulses along the z-axis (G sub(z): 23 mT/m; 250 ks rise-time; 920 Hz). The E-field from these EPI pulses is non-homogeneous, increasing linearly from the gradient's isocenter (radial and z directions), which allowed us to assess the correlation between local strength of the E-field and the regional metabolic differences between ON and OFF sessions. Metabolic images were normalized to metabolic activity in the plane positioned at the gradient's isocenter where E = 0 for both ON and OFF conditions. Statistical parametric analyses used to identify regions that differed between ON versus OFF (p < 0.05, corrected) showed that the relative metabolism was lower in areas at the poles of the brain (inferior occipital and frontal and superior parietal cortices) for ON than for OFF, which was also documented with individual region of interest analysis. Moreover the magnitude of the metabolic decrements was significantly correlated with the estimated strength of E (r = 0.68, p < 0.0001); the stronger the E-field the larger the decreases. However, we did not detect differences between ON versus OFF conditions on mood ratings nor on absolute whole brain metabolism. This data provides preliminary evidence that EPI sequences may affect neuronal activity and merits further investigation. JF - NeuroImage AU - Volkow, Nora D AU - Tomasi, Dardo AU - Wang, Gene-Jack AU - Fowler, Joanna S AU - Telang, Frank AU - Wang, Ruiliang AU - Alexoff, Dave AU - Logan, Jean AU - Wong, Christopher AU - Pradhan, Kith AU - Caparelli, Elisabeth C AU - Ma, Yeming AU - Jayne, Millard AD - National Institute on Drug Abuse, Bethesda, MD 20892, USA, nvolkow@nida.nih.gov nvolkow@nida.nih.gov nvolkow@nida.nih.gov nvolkow@nida.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 623 EP - 628 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 51 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain imaging KW - Echo planar KW - Brain glucose metabolism KW - fMRI KW - Mood KW - Brain mapping KW - Magnetic fields KW - Neuroimaging KW - Statistics KW - Data processing KW - Functional magnetic resonance imaging KW - Brain KW - Positron emission tomography KW - Image processing KW - Glucose metabolism KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745636760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Effects+of+low-field+magnetic+stimulation+on+brain+glucose+metabolism&rft.au=Volkow%2C+Nora+D%3BTomasi%2C+Dardo%3BWang%2C+Gene-Jack%3BFowler%2C+Joanna+S%3BTelang%2C+Frank%3BWang%2C+Ruiliang%3BAlexoff%2C+Dave%3BLogan%2C+Jean%3BWong%2C+Christopher%3BPradhan%2C+Kith%3BCaparelli%2C+Elisabeth+C%3BMa%2C+Yeming%3BJayne%2C+Millard&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2010-06-01&rft.volume=51&rft.issue=2&rft.spage=623&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2010.02.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Mood; Magnetic fields; Brain mapping; Neuroimaging; Data processing; Statistics; Functional magnetic resonance imaging; Positron emission tomography; Brain; Image processing; Glucose metabolism DO - http://dx.doi.org/10.1016/j.neuroimage.2010.02.015 ER - TY - JOUR T1 - Repetitive Busulfan Administration After Hematopoietic Stem Cell Gene Therapy Associated with a Dominant HDAC7 Clone in a Nonhuman Primate AN - 744720193; 13134252 AB - The risk of genotoxicity of retroviral vector-delivered gene therapy targeting hematopoietic stem cells (HSCs) has been highlighted by the development of clonal dominance and malignancies in human and animal gene therapy trials. Large-animal models have proven invaluable to test the safety of retroviral vectors, but the detection of clonal dominance may require years of follow-up. We hypothesized that hematopoietic stress may accelerate the proliferation and therefore the detection of abnormal clones in these models. We administered four monthly busulfan (Bu) infusions to induce hematopoietic stress in a healthy rhesus macaque previously transplanted with CD34 super(+) cells transduced with retroviral vectors carrying a simple marker gene. Busulfan administration resulted in significant cytopenias with each cycle, and prolonged pancytopenia after the final cycle with eventual recovery. Before busulfan treatment there was highly polyclonal marking in all lineages. After Bu administration clonal diversity was markedly decreased in all lineages. Unexpectedly, we found no evidence of selection of the MDS1/EVI1 clones present before Bu administration, but a clone with a vector integration in intron 1 of the histone deacetylase-7 (HDAC7) gene became dominant in granulocytes over time after Bu administration. The overall marking level in the animal was increased significantly after Bu treatment and coincident with expansion of the HDAC7 clone, suggesting an in vivo advantage for this clone under stress. HDAC7 expression was upregulated in marrow progenitors containing the vector. Almost 5 years after Bu administration, the animal developed progressive cytopenias, and at autopsy the marrow showed complete lack of neutrophil or platelet maturation, with a new population of approximately 20% undifferentiated blasts. These data suggest that chemotherapeutic stress may accelerate vector-related clonal dominance, even in the absence of drug resistance genes expressed by the vector. This model may both accelerate the detection of abnormal clones to facilitate analysis of genotoxicity for human gene therapy, and help assess the safety of administering myelotoxic chemotherapeutic agents in patients previously engrafted with vector-containing cells. JF - Human Gene Therapy AU - Xie, J AU - Larochelle, A AU - Maric, I AU - Faulhaber, M AU - Donahue, R E AU - Dunbar, CE AD - Molecular Hematopoiesis Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA, dunbarc@mail.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 695 EP - 703 VL - 21 IS - 6 SN - 1043-0342, 1043-0342 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Autopsy KW - Histones KW - Chemotherapy KW - Drug resistance KW - Animal models KW - Expression vectors KW - Integration KW - Stem cells KW - Malignancy KW - Macaca mulatta KW - Blast KW - Data processing KW - Gene therapy KW - Genotoxicity KW - Leukocytes (neutrophilic) KW - Stress KW - CD34 antigen KW - Pancytopenia KW - Primates KW - Dominance KW - Leukocytes (granulocytic) KW - Busulfan KW - Platelets KW - Introns KW - Hemopoiesis KW - W 30905:Medical Applications KW - G 07880:Human Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744720193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Repetitive+Busulfan+Administration+After+Hematopoietic+Stem+Cell+Gene+Therapy+Associated+with+a+Dominant+HDAC7+Clone+in+a+Nonhuman+Primate&rft.au=Xie%2C+J%3BLarochelle%2C+A%3BMaric%2C+I%3BFaulhaber%2C+M%3BDonahue%2C+R+E%3BDunbar%2C+CE&rft.aulast=Xie&rft.aufirst=J&rft.date=2010-06-01&rft.volume=21&rft.issue=6&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2009.191 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Autopsy; Data processing; Histones; Gene therapy; Drug resistance; Chemotherapy; Genotoxicity; Leukocytes (neutrophilic); Animal models; Stress; Pancytopenia; CD34 antigen; Dominance; Expression vectors; Integration; Leukocytes (granulocytic); Malignancy; Stem cells; Busulfan; Introns; Platelets; Hemopoiesis; Blast; Macaca mulatta; Primates DO - http://dx.doi.org/10.1089/hum.2009.191 ER - TY - JOUR T1 - Curcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal AN - 744714547; 12873727 AB - Groundwater arsenic contamination has been a health hazard for West Bengal, India. Oxidative stress to DNA is recognized as an underlying mechanism of arsenic carcinogenicity. A phytochemical, curcumin, from turmeric appears to be potent antioxidant and antimutagenic agent. DNA damage prevention with curcumin could be an effective strategy to combat arsenic toxicity. This field trial in Chakdah block of West Bengal evaluated the role of curcumin against the genotoxic effects of arsenic. DNA damage in human lymphocytes was assessed by comet assay and fluorescence-activated DNA unwinding assay. Curcumin was analyzed in blood by high performance liquid chromatography (HPLC). Arsenic induced oxidative stress and elucidation of the antagonistic role of curcumin was done by observation on reactive oxygen species (ROS) generation, lipid peroxidation and protein carbonyl. Antioxidant enzymes like catalase, superoxide dismutase, glutathione reductase, glutathioneS-transferase, glutathione peroxidase and non-enzymatic glutathione were also analyzed. The blood samples of the endemic regions showed severe DNA damage with increased levels of ROS and lipid peroxidation. The antioxidants were found with depleted activity. Three months curcumin intervention reduced the DNA damage, retarded ROS generation and lipid peroxidation and raised the level of antioxidant activity. Thus curcumin may have some protective role against the DNA damage caused by arsenic. JF - Human & Experimental Toxicology AU - Biswas, Jaydip AU - Sinha, Dona AU - Mukherjee, Sutapa AU - Roy, Soumi AU - Siddiqi, Maqsood AU - Roy, Madhumita AD - Chittaranjan National Cancer Institute, Kolkata, India, mitacnci@yahoo.co.in Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 513 EP - 524 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 29 IS - 6 SN - 0960-3271, 0960-3271 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - High-performance liquid chromatography KW - glutathione reductase KW - Arsenic KW - Antioxidants KW - Curcumin KW - Contamination KW - Unwinding KW - Genotoxicity KW - Enzymes KW - Toxicity KW - Lymphocytes KW - Catalase KW - Lipid peroxidation KW - DNA damage KW - Reactive oxygen species KW - Carcinogenicity KW - Oxidative stress KW - Superoxide dismutase KW - Glutathione peroxidase KW - Curcuma longa KW - Ground water KW - Comet assay KW - carbonyls KW - N 14820:DNA Metabolism & Structure KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744714547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+Experimental+Toxicology&rft.atitle=Curcumin+protects+DNA+damage+in+a+chronically+arsenic-exposed+population+of+West+Bengal&rft.au=Biswas%2C+Jaydip%3BSinha%2C+Dona%3BMukherjee%2C+Sutapa%3BRoy%2C+Soumi%3BSiddiqi%2C+Maqsood%3BRoy%2C+Madhumita&rft.aulast=Biswas&rft.aufirst=Jaydip&rft.date=2010-06-01&rft.volume=29&rft.issue=6&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Human+%26+Experimental+Toxicology&rft.issn=09603271&rft_id=info:doi/10.1177%2F0960327109359020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 38 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - glutathione reductase; High-performance liquid chromatography; Arsenic; Curcumin; Antioxidants; Contamination; Unwinding; Genotoxicity; Enzymes; Lymphocytes; Toxicity; Lipid peroxidation; Catalase; DNA damage; Reactive oxygen species; Glutathione peroxidase; Superoxide dismutase; Oxidative stress; Carcinogenicity; Ground water; Comet assay; carbonyls; Curcuma longa DO - http://dx.doi.org/10.1177/0960327109359020 ER - TY - JOUR T1 - Targeting pandemic influenza: a primer on influenza antivirals and drug resistance AN - 744701470; 13114110 AB - The emergence of the 2009 H1N1 pandemic influenza A virus, as well as constant antigenic drift of seasonal influenza, underscores the remarkable versatility of this virus in adapting to the human population. While vaccines are the principal public health defence against influenza, rapid vaccine development can be a daunting task. Antiviral drugs offer the promise of inhibiting influenza regardless of its genetic variations. However, the rapid rise of resistance to several antivirals has highlighted the need for developing novel therapeutics with reduced drug resistance potential. In this review, we will summarize the effects of the currently licensed anti-influenza drugs as well as the candidates in development against the seasonal and the 2009 H1N1 pandemic influenza A virus with an emphasis on drug resistance. JF - Journal of Antimicrobial Chemotherapy AU - Moss, Ronald B AU - Davey, Richard T AU - Steigbigel, Roy T AU - Fang, Fang AD - 2 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, rmoss@nexbio.com Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 1086 EP - 1093 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 65 IS - 6 SN - 0305-7453, 0305-7453 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - pandemics KW - Antigenic drift KW - Antiviral agents KW - Influenza A virus KW - Drug resistance KW - Influenza A KW - Primers KW - Drug development KW - Vaccines KW - Public health KW - A 01340:Antibiotics & Antimicrobials KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744701470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Targeting+pandemic+influenza%3A+a+primer+on+influenza+antivirals+and+drug+resistance&rft.au=Moss%2C+Ronald+B%3BDavey%2C+Richard+T%3BSteigbigel%2C+Roy+T%3BFang%2C+Fang&rft.aulast=Moss&rft.aufirst=Ronald&rft.date=2010-06-01&rft.volume=65&rft.issue=6&rft.spage=1086&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkq100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - pandemics; Antigenic drift; Antiviral agents; Influenza A; Drug resistance; Drug development; Primers; Vaccines; Public health; Influenza A virus DO - http://dx.doi.org/10.1093/jac/dkq100 ER - TY - JOUR T1 - Occupational exposure to terbufos and the incidence of cancer in the Agricultural Health Study AN - 744615881; 12941712 AB - Objective: Terbufos is the fourth most commonly used organophosphate insecticide (OP) in the United States. Terbufos has not been demonstrated to be carcinogenic in rodents, although non-arsenical insecticides, including OPs, have been associated with excess cancer in epidemiologic studies. We investigated associations between use of terbufos and the incidence of cancer. Methods: The Agricultural Health Study is a prospective cohort study of 57,310 licensed pesticide applicators from Iowa and North Carolina. Detailed information about 50 pesticides, including terbufos, and potential confounders was obtained from self-administered questionnaires. Terbufos intensity-weighted lifetime exposure-days were defined as (lifetime exposure-days)(exposure intensity score). Cases include all first primary cancers diagnosed between enrollment and December 31, 2005. Hazard ratios (HR) and 95% CI were calculated with Cox proportional hazards models, adjusting for potential confounders. Results: Overall cancer risk was slightly increased among terbufos users [HR 1.21 (1.06-1.37)]. Suggestive associations were observed between terbufos use and cancers of the prostate (HR sub(highest tertile)=1.21; 95% CI=0.99-1.47) and lung (HR sub(middle tertile)=1.45; 95% CI=0.95-2.22) and leukemia (HR sub(middle tertile)=2.38; 95% CI=1.35-4.21) and non-Hodgkin's lymphoma (HR sub(middle tertile)=1.94; 95% CI=1.16-3.22), although the exposure-response gradients were non-monotonic and p for trends were not significant. Conclusion: We found suggestive associations between occupational terbufos use and several cancer sites. However, cautious interpretation of these results is warranted by the lack of existing experimental and epidemiologic evidence to support carcinogenic effects of terbufos. JF - Cancer Causes & Control AU - Bonner, Matthew R AU - Williams, Brent A AU - Rusiecki, Jennifer A AU - Blair, Aaron AU - Beane Freeman, Laura E AU - Hoppin, Jane A AU - Dosemeci, Mustafa AU - Lubin, Jay AU - Sandler, Dale P AU - Alavanja, Michael CR AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA, mrbonner@buffalo.edu Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 871 EP - 877 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 21 IS - 6 SN - 0957-5243, 0957-5243 KW - Risk Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - non-Hodgkin's lymphoma KW - USA, North Carolina KW - Organophosphates KW - Models KW - Non-Hodgkin's lymphoma KW - Leukemia KW - Insecticides KW - Carcinogenicity KW - Dose-response effects KW - Occupational exposure KW - Inventories KW - organophosphates KW - Cancer KW - Prostate cancer KW - USA, Iowa KW - Lung KW - Pesticides KW - Prostate KW - rodents KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744615881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Occupational+exposure+to+terbufos+and+the+incidence+of+cancer+in+the+Agricultural+Health+Study&rft.au=Bonner%2C+Matthew+R%3BWilliams%2C+Brent+A%3BRusiecki%2C+Jennifer+A%3BBlair%2C+Aaron%3BBeane+Freeman%2C+Laura+E%3BHoppin%2C+Jane+A%3BDosemeci%2C+Mustafa%3BLubin%2C+Jay%3BSandler%2C+Dale+P%3BAlavanja%2C+Michael+CR&rft.aulast=Bonner&rft.aufirst=Matthew&rft.date=2010-06-01&rft.volume=21&rft.issue=6&rft.spage=871&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-010-9514-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Inventories; organophosphates; Cancer; Models; Leukemia; Non-Hodgkin's lymphoma; Insecticides; Prostate cancer; Lung; Dose-response effects; Pesticides; Prostate; Occupational exposure; non-Hodgkin's lymphoma; Organophosphates; Carcinogenicity; rodents; USA, North Carolina; USA, Iowa DO - http://dx.doi.org/10.1007/s10552-010-9514-9 ER - TY - JOUR T1 - Risk of non-Hodgkin lymphoma and nitrate and nitrite from the diet in Connecticut women AN - 744615686; 12941715 AB - It has been estimated that 65,980 individuals were diagnosed with non-Hodgkin lymphoma (NHL) and 19,500 died from NHL in the United States in 2009. Although established risk factors such as immunodeficiency and viral infections may be responsible for a portion of the cases, the majority of NHL cases remain unexplained. Dietary nitrate and nitrite intake are exposures of particular interest for NHL risk as they are precursors in the endogenous formation of N-nitroso compounds, which cause lymphomas in animal studies. We investigated NHL risk overall and by histologic type in relation to dietary nitrate and nitrite intake in a population-based case-control study of 1,304 women in Connecticut. Nitrate and nitrite intake were assessed using a 120-item food frequency questionnaire. We found no association between risk of NHL overall and dietary nitrate and a slightly increased risk of NHL with higher dietary nitrite intake (highest vs. lowest intake quartile OR=1.4; 95% CI: 0.9-2.2). When we evaluated intake by subtype, a significant positive trend was observed for follicular lymphoma and nitrate (p-trend=0.04) and nitrite (p-trend<0.01) with an over twofold risk in the highest nitrite intake quartile (OR=2.3; 95% CI: 1.1-4.9). An increased risk in the highest quartile of nitrite intake was also observed for T-cell lymphoma (OR=3.4; 95% CI: 1.0-11.9). Animal products containing nitrite were more strongly associated with risk of follicular lymphoma; whereas, both animal and plant sources of nitrite were associated with elevated ORs for T-cell lymphoma. Our results confirm a previous finding for nitrite intake and NHL risk and highlight the importance of evaluating histologic type. We conclude that these results should be replicated in a larger study with data on drinking water as well as dietary sources of nitrate intake. JF - Cancer Causes & Control AU - Kilfoy, Briseis A AU - Ward, Mary H AU - Zheng, Tongzhang AU - Holford, Theodore R AU - Boyle, Peter AU - Zhao, Ping AU - Dai, Min AU - Leaderer, Brian AU - Zhang, Yawei AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, EPS, Room 8111, 6120 Executive Boulevard, Rockville, MD, 20852-7244, USA, kilfoyb@mail.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 889 EP - 896 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 21 IS - 6 SN - 0957-5243, 0957-5243 KW - Virology & AIDS Abstracts; Risk Abstracts; Immunology Abstracts KW - non-Hodgkin's lymphoma KW - Nitrate KW - USA, Connecticut KW - Food KW - Immunodeficiency KW - animal products KW - Infection KW - Risk factors KW - Nitrite KW - Diets KW - Inventories KW - Data processing KW - Nitrates KW - Cancer KW - N-Nitroso compounds KW - Nitrites KW - Females KW - T-cell lymphoma KW - Drinking water KW - lymphoma KW - V 22350:Immunology KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744615686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Risk+of+non-Hodgkin+lymphoma+and+nitrate+and+nitrite+from+the+diet+in+Connecticut+women&rft.au=Kilfoy%2C+Briseis+A%3BWard%2C+Mary+H%3BZheng%2C+Tongzhang%3BHolford%2C+Theodore+R%3BBoyle%2C+Peter%3BZhao%2C+Ping%3BDai%2C+Min%3BLeaderer%2C+Brian%3BZhang%2C+Yawei&rft.aulast=Kilfoy&rft.aufirst=Briseis&rft.date=2010-06-01&rft.volume=21&rft.issue=6&rft.spage=889&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-010-9517-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diets; Inventories; Nitrate; N-Nitroso compounds; Data processing; Food; Risk factors; Immunodeficiency; Nitrite; Infection; Drinking water; T-cell lymphoma; non-Hodgkin's lymphoma; Nitrates; Nitrites; Females; animal products; lymphoma; Cancer; USA, Connecticut DO - http://dx.doi.org/10.1007/s10552-010-9517-6 ER - TY - JOUR T1 - Single-trial fMRI Shows Contralesional Activity Linked to Overt Naming Errors in Chronic Aphasic Patients AN - 744441558; 201015068 AB - We used fMRI to investigate the roles played by perilesional and contralesional cortical regions during language production in stroke patients with chronic aphasia. We applied comprehensive psycholinguistic analyses based on well-established models of lexical access to overt picture-naming responses which were evaluated using a single trial design that permitted distinction between correct and incorrect responses on a trial-by-trial basis. Although both correct and incorrect naming responses were associated with left-sided perilesional activation, incorrect responses were selectively associated with robust right-sided contralesional activity. Most notably, incorrect responses elicited overactivation in the right inferior frontal gyrus that was not observed in the contrasts for patients' correct responses or for responses of age-matched control subjects. Errors were produced at slightly later onsets than accurate responses and comprised predominantly semantic paraphasias and omissions. Both types of errors were induced by pictures with greater numbers of alternative names, and omissions were also induced by pictures with late acquired names. These two factors, number of alternative names per picture and age of acquisition, were positively correlated with activation in left and right inferior frontal gyri in patients as well as control subjects. These results support the hypothesis that some right frontal activation may normally be associated with increasing naming difficulty, but in patients with aphasia, right frontal overactivation may reflect ineffective effort when left hemisphere perilesional resources are insufficient. They also suggest that contralesional areas continue to play a role -- dysfunctional rather than compensatory -- in chronic aphasic patients who have experienced a significant degree of recovery. Adapted from the source document JF - Journal of Cognitive Neuroscience AU - Postman-Caucheteux, Whitney Anne AU - Birn, Rasmus M AU - Pursley, Randall H AU - Butman, John A AU - Solomon, Jeffrey M AU - Picchioni, Dante AU - McArdle, Joe AU - Braun, Allen R AD - National Institutes of Health, Bethesda, MD Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 1299 EP - 1318 VL - 22 IS - 6 SN - 0898-929X, 0898-929X KW - Naming (56135) KW - Functional Magnetic Resonance Imaging (fMRI) (26525) KW - Psycholinguistics (69200) KW - Aphasia (03400) KW - Error Analysis (Language) (22400) KW - Stroke (84610) KW - Lateralization (Neurolinguistics) (45385) KW - Lexical Access (46630) KW - Age of Acquisition (01154) KW - article KW - 6414: language-pathological and normal; aphasia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744441558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cognitive+Neuroscience&rft.atitle=Single-trial+fMRI+Shows+Contralesional+Activity+Linked+to+Overt+Naming+Errors+in+Chronic+Aphasic+Patients&rft.au=Postman-Caucheteux%2C+Whitney+Anne%3BBirn%2C+Rasmus+M%3BPursley%2C+Randall+H%3BButman%2C+John+A%3BSolomon%2C+Jeffrey+M%3BPicchioni%2C+Dante%3BMcArdle%2C+Joe%3BBraun%2C+Allen+R&rft.aulast=Postman-Caucheteux&rft.aufirst=Whitney&rft.date=2010-06-01&rft.volume=22&rft.issue=6&rft.spage=1299&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cognitive+Neuroscience&rft.issn=0898929X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2010-07-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCONEO N1 - SubjectsTermNotLitGenreText - Functional Magnetic Resonance Imaging (fMRI) (26525); Naming (56135); Error Analysis (Language) (22400); Aphasia (03400); Stroke (84610); Psycholinguistics (69200); Lexical Access (46630); Lateralization (Neurolinguistics) (45385); Age of Acquisition (01154) ER - TY - JOUR T1 - Adolescent health brief: Lower Lateral Orbitofrontal Cortex Density Associated With More Frequent Exposure to Television and Movie Violence in Male Adolescents AN - 742729992; 201018679 AB - The relationship between cortical grey matter density and media violence exposure in healthy male adolescents was investigated using voxel-based morphometry and the Childrens' Report of Exposure to Violence. Adolescents with more frequent exposure have lower left lateral orbitofrontal cortex density-a possible risk factor for altered socioemotional functioning. [Copyright The Society for Adolescent Medicine; published by Elsevier Inc.] JF - Journal of Adolescent Health AU - Strenziok, Maren AU - Krueger, Frank AU - Pulaski, Sarah J AU - Openshaw, Anne E AU - Zamboni, Giovanna AU - van der Meer, Elke AU - Grafman, Jordan AD - National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 607 EP - 609 PB - Elsevier, New York NY VL - 46 IS - 6 SN - 1054-139X, 1054-139X KW - Voxel-based morphometry Media Aggression KW - Adolescent boys KW - Cortex KW - Men KW - Density KW - Violence KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742729992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=Adolescent+health+brief%3A+Lower+Lateral+Orbitofrontal+Cortex+Density+Associated+With+More+Frequent+Exposure+to+Television+and+Movie+Violence+in+Male+Adolescents&rft.au=Strenziok%2C+Maren%3BKrueger%2C+Frank%3BPulaski%2C+Sarah+J%3BOpenshaw%2C+Anne+E%3BZamboni%2C+Giovanna%3Bvan+der+Meer%2C+Elke%3BGrafman%2C+Jordan&rft.aulast=Strenziok&rft.aufirst=Maren&rft.date=2010-06-01&rft.volume=46&rft.issue=6&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/10.1016%2Fj.jadohealth.2009.11.196 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JAHCD9 N1 - SubjectsTermNotLitGenreText - Adolescents; Adolescent boys; Violence; Density; Men; Cortex DO - http://dx.doi.org/10.1016/j.jadohealth.2009.11.196 ER - TY - JOUR T1 - Social anxiety disorder and alcohol use disorder co-morbidity in the National Epidemiologic Survey on Alcohol and Related Conditions AN - 742729478; 201018397 AB - To assess the prevalence and clinical impact of co-morbid social anxiety disorder (SAD) and alcohol use disorders (AUD, i.e. alcohol abuse and alcohol dependence) in a nationally representative sample of adults in the United States. Data came from a large representative sample of the US population. Face-to-face interviews of 43093 adults residing in households were conducted during 2001-2002. Diagnoses of mood, anxiety, alcohol and drug use disorders and personality disorders were based on the Alcohol Use Disorder and Associated Disabilities Interview Schedule - DSM-IV version. Lifetime prevalence of co-morbid AUD and SAD in the general population was 2.4%. SAD was associated with significantly increased rates of alcohol dependence [odds ratio (OR) 2.8] and alcohol abuse (OR 1.2). Among respondents with alcohol dependence, SAD was associated with significantly more mood, anxiety, psychotic and personality disorders. Among respondents with SAD, alcohol dependence and abuse were most strongly associated with more substance use disorders, pathological gambling and antisocial personality disorders. SAD occurred before alcohol dependence in 79.7% of co-morbid cases, but co-morbidity status did not influence age of onset for either disorder. Co-morbid SAD was associated with increased severity of alcohol dependence and abuse. Respondents with co-morbid SAD and alcohol dependence or abuse reported low rates of treatment-seeking. Co-morbid lifetime AUD and SAD is a prevalent dual diagnosis, associated with substantial rates of additional co-morbidity, but remaining largely untreated. Future research should clarify the etiology of this co-morbid presentation to better identify effective means of intervention. Adapted from the source document. JF - Psychological Medicine AU - Schneier, F R AU - Foose, T E AU - Hasin, D S AU - Heimberg, R G AU - Liu, S.-M. AU - Grant, B F AU - Blanco, C AD - New York State Psychiatric Institute, New York, New York, USA Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 977 EP - 988 PB - Cambridge University Press, UK VL - 40 IS - 6 SN - 0033-2917, 0033-2917 KW - Alcohol dependence KW - Moods KW - Alcohol related disorders KW - Comorbidity KW - Prevalence KW - Personality disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742729478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Social+anxiety+disorder+and+alcohol+use+disorder+co-morbidity+in+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions&rft.au=Schneier%2C+F+R%3BFoose%2C+T+E%3BHasin%2C+D+S%3BHeimberg%2C+R+G%3BLiu%2C+S.-M.%3BGrant%2C+B+F%3BBlanco%2C+C&rft.aulast=Schneier&rft.aufirst=F&rft.date=2010-06-01&rft.volume=40&rft.issue=6&rft.spage=977&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291709991231 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Comorbidity; Alcohol dependence; Alcohol related disorders; Moods; Personality disorders; Prevalence DO - http://dx.doi.org/10.1017/S0033291709991231 ER - TY - JOUR T1 - The first decade of the National Drug Abuse Treatment Clinical Trials Network: Bridging the gap between research and practice to improve drug abuse treatment AN - 742729012; 201018743 AB - The National Institute on Drug Abuse established the National Drug Abuse Treatment Clinical Trials Network (CTN) in 1999 to improve the quality of addiction treatment using science as the vehicle. The network brings providers from community-based drug abuse treatment programs and scientists from university-based research centers together in an alliance that fosters bidirectional communication and collaboration. Collaboration enhanced the relevance of research to practice and facilitated the development and implementation of evidence-based treatments in community practice settings. The CTN's 20 completed trials tested pharmacological, behavioral, and integrated treatment interventions for adolescents and adults; more than 11,000 individuals participated in the trials. This article reviews the rationale for the CTN, describes the translation of its guiding principles into research endeavors, and anticipates the future evolution of clinical research within the Network. [Copyright Elsevier Inc.] JF - Journal of Substance Abuse Treatment AU - Tai, Betty AU - Straus, Michele M AU - Liu, David AU - Sparenborg, Steven AU - Jackson, Ron AU - McCarty, Dennis AD - Center for the Clinical Trials Network, National Institute on Drug Abuse, National Institutes of Health, Rockville, MD 20892, USA btai@nida.nih.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - S4 EP - S13 PB - Elsevier, New York NY VL - 38 SN - 0740-5472, 0740-5472 KW - Clinical Trials Network Drug abuse treatment Research KW - Translation KW - Clinical research KW - Drug addiction KW - Treatment methods KW - Drug abuse KW - Clinical trials KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742729012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=The+first+decade+of+the+National+Drug+Abuse+Treatment+Clinical+Trials+Network%3A+Bridging+the+gap+between+research+and+practice+to+improve+drug+abuse+treatment&rft.au=Tai%2C+Betty%3BStraus%2C+Michele+M%3BLiu%2C+David%3BSparenborg%2C+Steven%3BJackson%2C+Ron%3BMcCarty%2C+Dennis&rft.aulast=Tai&rft.aufirst=Betty&rft.date=2010-06-01&rft.volume=38&rft.issue=&rft.spage=S4&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/10.1016%2Fj.jsat.2010.01.011 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-27 N1 - CODEN - JSATEG N1 - SubjectsTermNotLitGenreText - Drug abuse; Clinical trials; Treatment methods; Translation; Drug addiction; Clinical research DO - http://dx.doi.org/10.1016/j.jsat.2010.01.011 ER - TY - JOUR T1 - The effect of parental modeling of anxious behaviors and cognitions in school-aged children: An experimental pilot study AN - 742726148; 201015317 AB - The current study tested: (1) the impact of parental modeling of anxious behaviors and cognitions on child anxiety level, anxious cognitions, desired avoidance, and objective performance using an experimental paradigm; and (2) whether the impact of parental modeling of anxious behaviors and cognitions differed by parent gender. Twenty-five parents (a random selection of 12 male and 13 female parents) participated with one of their children (ages 8-12 years; 56.0% male; 76.0% Caucasian). All children experienced two test conditions: an anxious condition in which their parent was trained to act anxiously before a planned spelling test and a non-anxious condition in which their parent was trained to act in a relaxed and confident manner before a planned spelling test. Results showed that, regardless of parent gender, children endorsed higher anxiety levels, anxious cognitions, and desired avoidance of the spelling test in the anxious relative to the non-anxious condition. Parental modeling of anxiety did not affect child spelling performance. Significant interaction effects indicated that fathers had a stronger impact on child anxiety level and cognitions than did mothers. Results highlight the importance of parental modeling and the potential role of both mothers and fathers in prevention and treatment for child anxiety. [Copyright Elsevier Ltd.] JF - Behaviour Research and Therapy AU - Burstein, Marcy AU - Ginsburg, Golda S AD - Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, 600 North Wolfe Street/CMSC 312, Baltimore, MD 21287-3325, USA bursteinme@mail.nih.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 506 EP - 515 PB - Elsevier, Amsterdam The Netherlands VL - 48 IS - 6 SN - 0005-7967, 0005-7967 KW - Parental modeling of anxiety Child anxiety Parent gender Etiology KW - Anxiety disorders KW - Spelling KW - Anxiety KW - Children KW - Parents KW - Cognition KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742726148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behaviour+Research+and+Therapy&rft.atitle=The+effect+of+parental+modeling+of+anxious+behaviors+and+cognitions+in+school-aged+children%3A+An+experimental+pilot+study&rft.au=Burstein%2C+Marcy%3BGinsburg%2C+Golda+S&rft.aulast=Burstein&rft.aufirst=Marcy&rft.date=2010-06-01&rft.volume=48&rft.issue=6&rft.spage=506&rft.isbn=&rft.btitle=&rft.title=Behaviour+Research+and+Therapy&rft.issn=00057967&rft_id=info:doi/10.1016%2Fj.brat.2010.02.006 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - BRTHAA N1 - SubjectsTermNotLitGenreText - Parents; Children; Anxiety disorders; Cognition; Anxiety; Spelling DO - http://dx.doi.org/10.1016/j.brat.2010.02.006 ER - TY - JOUR T1 - Pathways linking socioeconomic status to obesity through depression and lifestyle factors among young US adults AN - 742721373; 201012767 AB - Obesity and depression are two diseases of major public health importance. While both correlate with each other, potential pathways involving depression that would link socioeconomic status (SES) to lifestyle factors and obesity have not been systematically examined using nationally representative data. Using rich data on 2217 US young adults aged 20-39 years from the 1999-2004 National Health and Nutrition Surveys (NHANES) and multivariate linear and logistic regression models, we examined associations between major depressive disorder (MDD), dietary intake, physical activity (PA), and measured body mass index (BMI) controlling for socio-demographic factors. Further, structural equation models (SEM) were fit to test pathway explaining SES disparities in BMI through MDD and lifestyle factors. Recent prevalence of MDD was lower among young US men than women (6.4% vs. 9.2%) although their prevalence of obesity was similar (21.2% vs. 22.7%). Among women, MDD was associated with higher BMI and inversely associated with PA, but not among men. MDD was specifically associated with increased risk of morbid obesity (BMI >= 40) among women (OR: 2.88 (1.32, 6.30)). Using SEM, a main pathway linking SES to BMI among women was linking SES -> food insecurity -> MDD -> PA -> BMI. A main pathway linking MDD to BMI in both genders was going through PA rather than overall dietary quality. Gender and ethnic differences existed underlying how MDD, SES and lifestyle factors were associated with adiposity. Future prospective studies are needed to examine potential mechanisms using physiological markers of depression, lifestyle and obesity. [Copyright Elsevier B.V.] JF - Journal of Affective Disorders AU - Beydoun, May A AU - Wang, Youfa AD - National Institute on Aging, NIA/NIH/IRP, Baltimore, MD, United States Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 52 EP - 63 PB - Elsevier Ltd, The Netherlands VL - 123 IS - 1-3 SN - 0165-0327, 0165-0327 KW - Depression Body mass index Obesity Socio-economic status Diet Physical activity KW - Depressive personality disorders KW - Obesity KW - Depression KW - Socioeconomic status KW - Body Mass Index KW - Lifestyle KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742721373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Affective+Disorders&rft.atitle=Pathways+linking+socioeconomic+status+to+obesity+through+depression+and+lifestyle+factors+among+young+US+adults&rft.au=Beydoun%2C+May+A%3BWang%2C+Youfa&rft.aulast=Beydoun&rft.aufirst=May&rft.date=2010-06-01&rft.volume=123&rft.issue=1-3&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Journal+of+Affective+Disorders&rft.issn=01650327&rft_id=info:doi/10.1016%2Fj.jad.2009.09.021 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-06-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Depressive personality disorders; Body Mass Index; Socioeconomic status; Lifestyle; Obesity; Depression DO - http://dx.doi.org/10.1016/j.jad.2009.09.021 ER - TY - JOUR T1 - The effects of kappa-opioid receptor ligands on prepulse inhibition and CRF-induced prepulse inhibition deficits in the rat. AN - 733956621; 20232058 AB - Kappa-opioid receptor (KOR) agonists produce dysphoria and psychotomimesis in humans. KORs are enriched in the prefrontal cortex and other brain regions that regulate mood and cognitive function. Dysregulation of the dynorphin/KOR system has been implicated in the pathogenesis of schizophrenia, depression, and bipolar disorder. Prepulse inhibition of the acoustic startle reflex (PPI), a sensorimotor gating process, is disrupted in many psychiatric disorders. The present study determined whether KOR ligands alter PPI in rats. Utilizing a range of doses of the synthetic KOR agonists (+/-) U50,488, (-) U50,488, and U69,593 and the naturally occurring KOR agonist, Salvinorin A, we demonstrate that KOR activation does not alter PPI or startle reactivity in rats. Similarly, selective KOR blockade using the long-acting antagonist nor-binaltorphimine (nor-BNI) was without effect. In contrast to KOR ligands, MK-801 and quinpirole produced deficits in PPI. Stress and corticotropin-releasing factor (CRF) decrease PPI levels. The dynorphin/KOR system has been suggested to be a key mediator of various behavioral effects produced by stress and CRF. We therefore examined the contribution of KORs to CRF-induced alterations in PPI. Intracerebroventricular infusion of CRF decreased PPI. Administration of nor-BNI failed to affect the CRF-evoked disruption in PPI. Together, these results provide no evidence of a link between the dynorphin/KOR system and deficits in sensory gating processes. Additional studies, however, examining whether dysregulation of this opioid system contributes to cognitive deficits and other behavioral abnormalities associated with psychiatric disorders are warranted. JF - Psychopharmacology AU - Tejeda, Hugo A AU - Chefer, Vladimir I AU - Zapata, Agustin AU - Shippenberg, Toni S AD - Integrative Neuroscience Section, Integrative Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, NIDA/IRP 333 Cassell Dr., Baltimore, MD 21224, USA. Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 231 EP - 240 VL - 210 IS - 2 KW - Benzeneacetamides KW - 0 KW - Diterpenes, Clerodane KW - Ligands KW - Pyrrolidines KW - Receptors, Opioid, kappa KW - norbinaltorphimine KW - 36OOQ86QM1 KW - Naltrexone KW - 5S6W795CQM KW - 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer KW - 67198-13-4 KW - Corticotropin-Releasing Hormone KW - 9015-71-8 KW - U 69593 KW - J5S4K6TKTG KW - salvinorin A KW - T56W91NG6J KW - Index Medicus KW - Rats KW - Benzeneacetamides -- pharmacology KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer -- pharmacology KW - Naltrexone -- analogs & derivatives KW - Naltrexone -- pharmacology KW - Pyrrolidines -- pharmacology KW - Neural Inhibition KW - Diterpenes, Clerodane -- pharmacology KW - Male KW - Reflex, Startle -- drug effects KW - Receptors, Opioid, kappa -- agonists KW - Receptors, Opioid, kappa -- antagonists & inhibitors KW - Corticotropin-Releasing Hormone -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733956621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=The+effects+of+kappa-opioid+receptor+ligands+on+prepulse+inhibition+and+CRF-induced+prepulse+inhibition+deficits+in+the+rat.&rft.au=Tejeda%2C+Hugo+A%3BChefer%2C+Vladimir+I%3BZapata%2C+Agustin%3BShippenberg%2C+Toni+S&rft.aulast=Tejeda&rft.aufirst=Hugo&rft.date=2010-06-01&rft.volume=210&rft.issue=2&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=1432-2072&rft_id=info:doi/10.1007%2Fs00213-010-1799-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-17 N1 - Date created - 2010-05-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genes Brain Behav. 2002 Aug;1(3):178-86 [12884974] Eur J Neurosci. 2003 Jul;18(2):391-402 [12887421] Neuropsychopharmacology. 2003 Oct;28(10):1790-8 [12865891] J Neurosci. 2004 Jul 21;24(29):6545-52 [15269266] Ann N Y Acad Sci. 1986;467:82-92 [3460473] Science. 1986 Aug 15;233(4765):774-6 [3016896] Psychopharmacology (Berl). 1988;94(4):507-14 [3131796] Proc Natl Acad Sci U S A. 1988 Jul;85(14):5274-8 [2899326] Behav Neurosci. 1989 Feb;103(1):151-7 [2923668] Am J Psychiatry. 1989 Jul;146(7):866-70 [2742011] Pharmacol Biochem Behav. 1990 Feb;35(2):429-35 [1969641] Psychopharmacology (Berl). 1990;101(3):414-20 [2114026] J Pharmacol Exp Ther. 1991 Feb;256(2):530-6 [1825226] Psychiatry Res. 1990 Dec;34(3):229-36 [1706098] Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2046-50 [1347943] Arch Int Pharmacodyn Ther. 1992 Mar-Apr;316:30-42 [1326932] J Pharmacol Exp Ther. 1994 Nov;271(2):787-94 [7965797] Psychopharmacology (Berl). 1993;113(1):103-9 [7862814] Psychopharmacology (Berl). 1994 Jan;113(3-4):487-92 [7862864] Eur J Neurosci. 1994 Dec 1;6(12):1837-45 [7704295] Neurosci Lett. 1995 Aug 4;195(2):125-8 [7478266] Psychopharmacology (Berl). 1995 Nov;122(1):35-43 [8711062] Psychopharmacology (Berl). 2008 Oct;200(3):403-11 [18607572] Behav Pharmacol. 2008 Dec;19(8):786-95 [19020413] J Clin Psychiatry. 2008 Sep;69(9):1501-2 [19193352] J Neurosci. 2009 Apr 1;29(13):4293-300 [19339623] J Neuroendocrinol. 2009 Mar;21(4):415-20 [19187468] Schizophr Bull. 2009 May;35(3):549-62 [19325164] Pharmacol Ther. 2009 Sep;123(3):334-43 [19497337] Schizophr Res. 2009 Sep;113(2-3):298-307 [19500946] J Psychiatr Res. 2010 Jan;44(2):106-11 [19573876] Brain Res. 2010 Feb 16;1314:44-55 [19716811] Neuropsychopharmacology. 2000 May;22(5):551-4 [10731631] J Neurosci. 2000 Jun 1;20(11):4325-36 [10818168] Pharmacol Biochem Behav. 2000 Jun;66(2):403-11 [10880697] J Neurosci. 2000 Dec 15;20(24):9333-40 [11125013] J Neurosci. 2001 Jan 1;21(1):305-13 [11150348] Prog Neuropsychopharmacol Biol Psychiatry. 2000 Oct;24(7):1177-201 [11131179] Neuroscience. 1996 Jun;72(3):767-83 [9157322] Neuroscience. 1996 Apr;71(3):671-90 [8867040] Psychiatry Res. 1996 Oct 16;64(3):169-78 [8944395] Neuroscience. 1998 Jul;85(2):375-82 [9622237] J Pharmacol Exp Ther. 1998 Sep;286(3):1356-73 [9732399] Synapse. 1998 Nov;30(3):255-62 [9776129] Ann N Y Acad Sci. 1999 Jun 29;877:202-16 [10415651] Prog Neuropsychopharmacol Biol Psychiatry. 2005 May;29(4):581-6 [15866361] J Neurosci. 2005 May 18;25(20):5029-37 [15901784] Biol Psychiatry. 2005 Jun 15;57(12):1550-8 [15953492] Psychiatry Res. 2005 Sep 15;136(2-3):201-9 [16126279] Neuroscience. 2005;135(2):385-94 [16125865] Behav Neurosci. 2005 Aug;119(4):1052-60 [16187833] J Pharmacol Exp Ther. 2006 Jan;316(1):440-7 [16223871] Eur J Neurosci. 2006 Jan;23(1):229-38 [16420432] Neuropsychopharmacology. 2006 Apr;31(4):787-94 [16123754] Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2938-42 [16477003] Neuropsychopharmacology. 2006 Oct;31(10):2132-9 [16407898] Neurotox Res. 2006 Dec;10(3-4):211-20 [17197371] Pharmacol Biochem Behav. 2007 Mar;86(3):550-8 [17324452] Psychiatry Res. 2007 May 30;151(1-2):139-43 [17395273] Neurobiol Learn Mem. 2007 Jul;88(1):94-103 [17374494] Pharmacol Biochem Behav. 2007 May;87(1):1-10 [17475315] Schizophr Bull. 2007 Jul;33(4):912-20 [17567627] Cereb Cortex. 2007 Sep;17 Suppl 1:i6-15 [17434919] Biol Psychiatry. 2003 Feb 15;53(4):352-9 [12586455] Pharmacol Ther. 2007 Nov;116(2):306-21 [17868902] J Nerv Ment Dis. 2007 Nov;195(11):891-6 [18000450] J Pharmacol Exp Ther. 2007 Dec;323(3):838-45 [17823306] J Neurosci. 2008 Jan 9;28(2):407-14 [18184783] Biol Psychiatry. 2008 Feb 15;63(4):360-8 [17716630] Pharmacol Biochem Behav. 2008 May;89(3):324-37 [18280562] Neurosci Biobehav Rev. 2008 Aug;32(6):1121-35 [18514314] Psychopharmacology (Berl). 2008 Sep;200(1):59-70 [18575850] Neuropsychopharmacology. 2008 Oct;33(11):2648-56 [18075489] Neurotox Res. 2008 Aug;14(1):71-8 [18790726] Mol Psychiatry. 2002;7(1):75-81 [11803449] Psychopharmacology (Berl). 2002 May;161(3):296-303 [12021833] Physiol Behav. 2002 Apr 1;75(4):507-22 [12062315] Brain Res. 2002 Aug 16;946(2):262-71 [12137930] Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11934-9 [12192085] Biol Psychiatry. 2003 Jul 15;54(2):121-8 [12873801] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00213-010-1799-6 ER - TY - JOUR T1 - Reactive oxygen species mediate hepatotoxicity induced by the Hsp90 inhibitor geldanamycin and its analogs. AN - 733894180; 20211249 AB - Geldanamycin (GM), a benzoquinone ansamycin antibiotic, is a natural product inhibitor of Hsp90 with potent and broad anti-cancer properties. Because of its adverse effects on liver, its less toxic derivatives 17-(allylamino)-17-demethoxygeldanamycin (17-AAG) and 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG) are currently being evaluated for the treatment of cancer. Previously, it has been demonstrated that the redox cycling of GM by NADPH-cytochrome P450 reductase leads to the formation of the GM semiquinone and superoxide radicals, the latter being identified using spin-trapping. We hypothesized that the different hepatotoxicity induced by GM, 17-AAG and 17-DMAG reflects the redox active properties of the quinone moiety and possibly the extent of superoxide formation, which may stimulate cellular oxidative injury. Our data demonstrate that superoxide can be efficiently trapped during the reduction of GM, 17-AAG and 17-DMAG by NADPH-cytochrome P450 reductase, and that superoxide formation rate followed the order 17-DMAG > 17-AAG > GM. In the absence of superoxide scavengers, the rate of NADPH oxidation followed the order 17-DMAG > GM > 17-AAG. The half-wave one-electron reduction potentials (E(1/2)) of GM, 17-AAG and 17-DMAG in DMSO have been determined to be -0.37, -0.13 and -0.015V (vs. Ag/AgCl), respectively. If the same order of E(1/2) follows in neutral aqueous media, thermodynamic considerations imply that 17-DMAG is more readily reduced by the P450 reductase as well as by superoxide. The order of the drug cytotoxicity toward rat primary hepatocytes, as determined by their effect on cell viability and on intracellular oxidant level, was opposite to the order of E(1/2) of the respective quinone/semiquinone couples. These results suggest that hepatotoxicity exhibited by the Hsp90 inhibitors belonging to benzoquinone ansamycins could be attributed to superoxide. The apparent discrepancy between the order of toxicity and the orders of superoxide formation rate, which is correlated with E(1/2), is discussed. Published by Elsevier Inc. JF - Free radical biology & medicine AU - Samuni, Yuval AU - Ishii, Hisanari AU - Hyodo, Fuminori AU - Samuni, Uri AU - Krishna, Murali C AU - Goldstein, Sara AU - Mitchell, James B AD - Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2010/06/01/ PY - 2010 DA - 2010 Jun 01 SP - 1559 EP - 1563 VL - 48 IS - 11 KW - Benzoquinones KW - 0 KW - HSP90 Heat-Shock Proteins KW - Lactams, Macrocyclic KW - Reactive Oxygen Species KW - 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin KW - 001L2FE0M3 KW - tanespimycin KW - 4GY0AVT3L4 KW - geldanamycin KW - Z3K3VJ16KU KW - Index Medicus KW - Rats KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Benzoquinones -- pharmacology KW - Lactams, Macrocyclic -- pharmacology KW - HSP90 Heat-Shock Proteins -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733894180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Reactive+oxygen+species+mediate+hepatotoxicity+induced+by+the+Hsp90+inhibitor+geldanamycin+and+its+analogs.&rft.au=Samuni%2C+Yuval%3BIshii%2C+Hisanari%3BHyodo%2C+Fuminori%3BSamuni%2C+Uri%3BKrishna%2C+Murali+C%3BGoldstein%2C+Sara%3BMitchell%2C+James+B&rft.aulast=Samuni&rft.aufirst=Yuval&rft.date=2010-06-01&rft.volume=48&rft.issue=11&rft.spage=1559&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=1873-4596&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2010.03.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-02 N1 - Date created - 2010-05-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5537-41 [1319064] Cancer Res. 1992 Apr 1;52(7):1721-8 [1551101] Cancer Chemother Pharmacol. 1995;36(4):305-15 [7628050] Cancer Chemother Pharmacol. 1998;41(5):417-22 [9523739] Cancer Res. 1998 Jun 1;58(11):2385-96 [9622079] Cancer Chemother Pharmacol. 2005 Mar;55(3):237-43 [15503027] Chem Rev. 2005 Jun;105(6):2457-70 [15941219] J Clin Oncol. 2005 Jun 20;23(18):4152-61 [15961763] Cancer Chemother Pharmacol. 2005 Dec;56(6):637-47 [15986212] Toxicol In Vitro. 2005 Dec;19(8):1079-88 [16081239] J Mol Med (Berl). 2006 Aug;84(8):635-46 [16741751] Drug Metab Dispos. 2007 Jan;35(1):21-9 [17012542] Cell Mol Life Sci. 2008 Jan;65(1):141-60 [17938860] Drug Metab Dispos. 2008 Oct;36(10):2050-7 [18635747] Eur J Cancer. 2010 Jan;46(2):340-7 [19945858] J Natl Cancer Inst. 1999 Nov 17;91(22):1940-9 [10564678] Expert Opin Biol Ther. 2002 Jan;2(1):3-24 [11772336] J Biol Chem. 2002 Jul 12;277(28):25480-5 [11983711] J Am Chem Soc. 2003 Jan 22;125(3):789-95 [12526680] Arch Biochem Biophys. 2004 Mar 1;423(1):12-22 [14989259] Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4003-8 [15020765] J Immunol Methods. 1983 Dec 16;65(1-2):55-63 [6606682] Proc Natl Acad Sci U S A. 1990 Feb;87(4):1620-4 [2154753] Free Radic Res Commun. 1990;8(4-6):219-29 [2191903] Biochim Biophys Acta. 1993 Jan 15;1161(1):73-8 [8380722] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2010.03.001 ER - TY - JOUR T1 - NIAID/NIH radiation/nuclear medical countermeasures product research and development program. AN - 733548179; 20445403 AB - One of the greatest national security threats to the United States is the detonation of an improvised nuclear device or a radiological dispersal device in a heavily populated area. The U.S. Government has addressed these threats with a two-pronged strategy of preventing organizations from obtaining weapons of mass destruction and preparing in case an event occurs. The National Institute of Allergy and Infectious Diseases (NIAID) contributes to these preparedness efforts by supporting basic research and development for chemical, biological, radiological, and nuclear countermeasures for civilian use. The Radiation Countermeasures Program at NIAID has established a broad research agenda focused on the development of new medical products to mitigate and treat acute and long-term radiation injury, promote the clearance of internalized radionuclides, and facilitate accurate individual dose and exposure assessment. This paper reviews the recent work and collaborations supported by the Radiation Countermeasures Program. JF - Health physics AU - Hafer, Nathaniel AU - Cassatt, David AU - Dicarlo, Andrea AU - Ramakrishnan, Narayani AU - Kaminski, Joseph AU - Norman, Mai-Kim AU - Maidment, Bert AU - Hatchett, Richard AD - Division of Allergy, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 903 EP - 905 VL - 98 IS - 6 KW - Index Medicus KW - United States KW - Public Health KW - International Cooperation KW - Civil Defense KW - Radioactive Hazard Release KW - Humans KW - Program Development KW - National Institute of Allergy and Infectious Diseases (U.S.) KW - Disaster Planning -- organization & administration KW - Terrorism -- legislation & jurisprudence KW - Radiation Injuries -- therapy KW - Disaster Planning -- methods KW - Terrorism -- prevention & control KW - Emergency Medical Services -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733548179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=NIAID%2FNIH+radiation%2Fnuclear+medical+countermeasures+product+research+and+development+program.&rft.au=Hafer%2C+Nathaniel%3BCassatt%2C+David%3BDicarlo%2C+Andrea%3BRamakrishnan%2C+Narayani%3BKaminski%2C+Joseph%3BNorman%2C+Mai-Kim%3BMaidment%2C+Bert%3BHatchett%2C+Richard&rft.aulast=Hafer&rft.aufirst=Nathaniel&rft.date=2010-06-01&rft.volume=98&rft.issue=6&rft.spage=903&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=1538-5159&rft_id=info:doi/10.1097%2FHP.0b013e3181bbc4df LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-20 N1 - Date created - 2010-05-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/HP.0b013e3181bbc4df ER - TY - JOUR T1 - Radiation combined injury: overview of NIAID research. AN - 733548172; 20445395 AB - The term "radiation combined injury" (RCI) is used to describe conditions where radiation injury is coupled with other insults such as burns, wounds, infection, or blunt trauma. A retrospective account of injuries sustained following the atomic bombing of Hiroshima estimates that RCI comprised approximately 65% of all injuries observed. Much of the research that has been performed on RCI was carried out during the Cold War and our understanding of the clinical problem RCI presents does not reflect the latest advances in medicine or science. Because concerns have increased that terrorists might employ radiological or nuclear weapons, and because of the likelihood that victims of such terrorism would experience RCI, the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health sponsored a meeting in 2007 to explore the state of the research in this area, identify programmatic gaps, and establish priorities for future research. As a follow-up to that meeting, in 2008 NIAID sponsored an initiative on RCI, leading to the award of several exploratory/developmental grants, the goals of which are to better understand biological synergy involved in RCI-induced damage, develop improved animal models for various type of RCI, and advance identification and testing of potential countermeasures to treat injuries that would be expected following a radiological or nuclear event. This program has already yielded new insight into the nature of combined injuries and has identified a number of novel and existing compounds that may be effective treatments for this condition. JF - Health physics AU - DiCarlo, Andrea L AU - Ramakrishnan, Narayani AU - Hatchett, Richard J AD - Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6610 Rockledge Drive, Bethesda, MD 20892, USA. Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 863 EP - 867 VL - 98 IS - 6 KW - Index Medicus KW - United States KW - Animals KW - Biomedical Research -- trends KW - Radioactive Hazard Release KW - Wound Healing KW - Humans KW - Disease Models, Animal KW - Mice KW - National Institute of Allergy and Infectious Diseases (U.S.) KW - Comorbidity KW - Rats KW - Nuclear Warfare KW - Dogs KW - Radiation KW - Radiation Injuries -- therapy KW - Radiation Injuries -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733548172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Radiation+combined+injury%3A+overview+of+NIAID+research.&rft.au=DiCarlo%2C+Andrea+L%3BRamakrishnan%2C+Narayani%3BHatchett%2C+Richard+J&rft.aulast=DiCarlo&rft.aufirst=Andrea&rft.date=2010-06-01&rft.volume=98&rft.issue=6&rft.spage=863&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=1538-5159&rft_id=info:doi/10.1097%2FHP.0b013e3181a6ee32 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-20 N1 - Date created - 2010-05-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/HP.0b013e3181a6ee32 ER - TY - JOUR T1 - Lactoferrin: the path from protein to gene. AN - 733517986; 20221787 AB - This review focuses on the basic research that was performed on the lactoferrin protein and gene that was conducted in my laboratory over the past 25 years. This manuscript will outline how we discovered that lactoferrin is a target gene for estrogen, and how the first mouse lactoferrin cDNA, promoter and gene was cloned. Additionally, study was further extended to investigating the human lactoferrin protein and gene. Lastly the expression of lactoferrin in various tissues of both human and rodent under various physiological conditions were examined. JF - Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine AU - Teng, Christina T AD - Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, MD K202, PO Box 12233, Research Triangle Park, NC 27709, USA. teng1@niehs.nih.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 359 EP - 364 VL - 23 IS - 3 KW - Lactoferrin KW - EC 3.4.21.- KW - Index Medicus KW - Animals KW - Promoter Regions, Genetic KW - Polymorphism, Single Nucleotide KW - Humans KW - Lactoferrin -- genetics KW - Lactoferrin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733517986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometals+%3A+an+international+journal+on+the+role+of+metal+ions+in+biology%2C+biochemistry%2C+and+medicine&rft.atitle=Lactoferrin%3A+the+path+from+protein+to+gene.&rft.au=Teng%2C+Christina+T&rft.aulast=Teng&rft.aufirst=Christina&rft.date=2010-06-01&rft.volume=23&rft.issue=3&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Biometals+%3A+an+international+journal+on+the+role+of+metal+ions+in+biology%2C+biochemistry%2C+and+medicine&rft.issn=1572-8773&rft_id=info:doi/10.1007%2Fs10534-010-9310-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-21 N1 - Date created - 2010-05-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10534-010-9310-8 ER - TY - JOUR T1 - Expression of TGF-beta signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics. AN - 733515914; 19937272 AB - The transforming growth factor beta (TGF-beta) pathway can play either a tumor-suppressing or a tumor-promoting role in human breast carcinogenesis. In order to determine whether expression of TGF-beta signaling factors varies by age at onset and breast tumor characteristics that have prognostic significance, we undertook a study of 623 women with invasive breast carcinoma enrolled in a population-based case-control study conducted in Poland from 2000 to 2003. TGF-beta signaling factors were analyzed by immunohistochemistry in tumor tissue microarrays. We found that most tumors expressed extracellular-TGF-beta1 (78%), TGF-beta2 (91%), TGF-beta3 (93%), TGF-betaR2 (72%), and phospho-SMAD2 (61%), whereas intracellular-TGF-beta1 was expressed in 32% of tumors. Expression of TGF-beta ligands (beta1, beta2, and beta3) was associated with prognostically favorable pathological features including small size, and low grade, and these associations were similar for ER-positive and negative tumors. On the contrary, expression of the receptor TGF-betaR2 was primarily associated with small tumor size among ER-negative tumors, while expression of the transcription factor phospho-SMAD2 was associated with positive nodal status among ER-negative tumors. The greater frequency of expression of phospho-SMAD2 in cancers associated with lymph node metastases is consistent with a pro-progression role for TGF-beta. In addition, expression of extracellular-TGF-beta1 (P = 0.005), TGF-betaR2 (P = 8.2E-11), and phospho-SMAD2 (P = 1.3E-8) was strongly associated with earlier age at onset, independent of ER status. Our data provide evidence that TGF-beta signaling patterns vary by age and pathologic features of prognostic significance including ER expression. These results warrant analysis in studies of clinical outcomes accounting for age, ER status and treatment. JF - Breast cancer research and treatment AU - Figueroa, Jonine D AU - Flanders, Kathleen C AU - Garcia-Closas, Montserrat AU - Anderson, William F AU - Yang, Xiaohong R AU - Matsuno, Rayna K AU - Duggan, Máire A AU - Pfeiffer, Ruth M AU - Ooshima, Akira AU - Cornelison, Robert AU - Gierach, Gretchen L AU - Brinton, Louise A AU - Lissowska, Jolanta AU - Peplonska, Beata AU - Wakefield, Lalage M AU - Sherman, Mark E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. figueroaj@mail.nih.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 727 EP - 735 VL - 121 IS - 3 KW - Biomarkers, Tumor KW - 0 KW - Receptors, Estrogen KW - Receptors, Transforming Growth Factor beta KW - Smad2 Protein KW - Transforming Growth Factor beta KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - transforming growth factor-beta type II receptor KW - EC 2.7.11.30 KW - Index Medicus KW - Smad2 Protein -- metabolism KW - Protein-Serine-Threonine Kinases -- metabolism KW - Age of Onset KW - Humans KW - Poland -- epidemiology KW - Receptors, Transforming Growth Factor beta -- metabolism KW - Prognosis KW - Aged KW - Receptors, Estrogen -- metabolism KW - Age Distribution KW - Adult KW - Case-Control Studies KW - Incidence KW - Middle Aged KW - Female KW - Biomarkers, Tumor -- metabolism KW - Breast Neoplasms -- pathology KW - Breast Neoplasms -- metabolism KW - Breast Neoplasms -- epidemiology KW - Transforming Growth Factor beta -- metabolism KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733515914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+cancer+research+and+treatment&rft.atitle=Expression+of+TGF-beta+signaling+factors+in+invasive+breast+cancers%3A+relationships+with+age+at+diagnosis+and+tumor+characteristics.&rft.au=Figueroa%2C+Jonine+D%3BFlanders%2C+Kathleen+C%3BGarcia-Closas%2C+Montserrat%3BAnderson%2C+William+F%3BYang%2C+Xiaohong+R%3BMatsuno%2C+Rayna+K%3BDuggan%2C+M%C3%A1ire+A%3BPfeiffer%2C+Ruth+M%3BOoshima%2C+Akira%3BCornelison%2C+Robert%3BGierach%2C+Gretchen+L%3BBrinton%2C+Louise+A%3BLissowska%2C+Jolanta%3BPeplonska%2C+Beata%3BWakefield%2C+Lalage+M%3BSherman%2C+Mark+E&rft.aulast=Figueroa&rft.aufirst=Jonine&rft.date=2010-06-01&rft.volume=121&rft.issue=3&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=Breast+cancer+research+and+treatment&rft.issn=1573-7217&rft_id=info:doi/10.1007%2Fs10549-009-0590-z LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-15 N1 - Date created - 2010-05-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Cancer Res. 2004 Jan 15;10(2):491-8 [14760070] Breast Cancer Res Treat. 2003 May;79(2):149-59 [12825850] Hum Pathol. 1992 Jan;23(1):13-20 [1544664] Cancer Res. 1992 Dec 15;52(24):6949-52 [1458485] Am J Epidemiol. 1995 Feb 15;141(4):300-4 [7840107] Br J Cancer. 2006 Jan 30;94(2):239-46 [16404434] Cancer Lett. 2006 Apr 8;235(1):100-13 [15949894] Br J Cancer. 2006 Jul 3;95(1):123-9 [16755295] Biochim Biophys Acta. 2007 Jan;1775(1):21-62 [16904831] Cancer Causes Control. 2007 May;18(4):439-47 [17216325] Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):439-43 [17372238] Int J Cancer. 2007 Sep 1;121(5):1079-85 [17487843] Nat Rev Mol Cell Biol. 2007 Nov;8(11):857-69 [17895899] Cell. 2008 Apr 4;133(1):66-77 [18394990] Cell. 2008 Jul 25;134(2):215-30 [18662538] Br J Cancer. 2008 Oct 21;99(8):1357-63 [18827819] J Natl Cancer Inst. 2008 Dec 17;100(24):1804-14 [19066264] Breast Cancer Res Treat. 2009 Jun;115(3):453-95 [18841463] J Clin Oncol. 2009 Nov 10;27(32):5308-11 [19826117] J Natl Cancer Inst. 1999 Dec 15;91(24):2096-101 [10601380] Histopathology. 2000 Feb;36(2):168-77 [10672063] Anticancer Res. 2000 Nov-Dec;20(6B):4413-8 [11205281] Nat Genet. 2001 Oct;29(2):117-29 [11586292] J Natl Cancer Inst Monogr. 2001;(30):44-51 [11773291] Curr Opin Genet Dev. 2002 Feb;12(1):22-9 [11790550] Cancer Res. 2002 Jan 15;62(2):497-505 [11809701] Mol Cell Endocrinol. 2003 May 30;203(1-2):185-96 [12782414] J Cell Biol. 1989 Feb;108(2):653-60 [2465297] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10549-009-0590-z ER - TY - JOUR T1 - mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiae. AN - 733311524; 20185557 AB - DNA polymerase gamma (pol gamma) is responsible for replication and repair of mitochondrial DNA (mtDNA). Over 150 mutations in POLG (which encodes pol gamma) have been discovered in patients with mitochondrial disorders including Alpers, progressive external ophthalmoplegia and ataxia-neuropathy syndrome. However, the severity and dominance of many POLG disease-associated mutations are unclear, because they have been reported in sporadic cases. To understand the consequences of pol gamma disease-associated mutations in vivo, we identified dominant and recessive changes in mtDNA mutagenesis, depletion and mitochondrial dysfunction caused by 31 mutations in the conserved regions of the gene, MIP1, which encodes the Saccharomyces cerevisiae ortholog of human pol gamma. Twenty mip1 mutant enzymes were shown to disrupt mtDNA replication and may be sufficient to cause disease. Previously uncharacterized sporadic mutations, Q308H, R807C, G1076V, R1096H and S1104C, caused decreased polymerase activity leading to mtDNA depletion and mitochondrial dysfunction. We present evidence showing a limited role of point mutagenesis by these POLG mutations in mitochondrial dysfunction and disease progression. Instead, most mitochondrial defective mip1 mutants displayed reduced or depleted mtDNA. We also determined that the severity of the phenotype of the mip1 mutant strain correlates with the age of onset of disease associated with the human ortholog. Finally, we demonstrated that increasing nucleotide pools by overexpression of ribonucleotide reductase (RNR1) suppressed mtDNA replication defects caused by several dominant mip1 mutations, and the orthologous human mutations revealed severe nucleotide binding defects. JF - Human molecular genetics AU - Stumpf, Jeffrey D AU - Bailey, Christopher M AU - Spell, Diana AU - Stillwagon, Matthew AU - Anderson, Karen S AU - Copeland, William C AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes ofHealth, Research, Triangle Park, NC 27709, USA. Y1 - 2010/06/01/ PY - 2010 DA - 2010 Jun 01 SP - 2123 EP - 2133 VL - 19 IS - 11 KW - DNA Primers KW - 0 KW - DNA, Mitochondrial KW - Saccharomyces cerevisiae Proteins KW - Histidine KW - 4QD397987E KW - DNA Polymerase I KW - EC 2.7.7.- KW - DNA polymerase gamma KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - MIP1 protein, S cerevisiae KW - Index Medicus KW - Histidine -- chemistry KW - DNA Replication -- genetics KW - Age Factors KW - Plasmids -- genetics KW - DNA Primers -- genetics KW - Humans KW - Mutation -- genetics KW - DNA, Mitochondrial -- genetics KW - Saccharomyces cerevisiae -- genetics KW - Phenotype KW - Mitochondrial Diseases -- genetics KW - Saccharomyces cerevisiae Proteins -- genetics KW - Models, Molecular KW - DNA Polymerase I -- genetics KW - DNA-Directed DNA Polymerase -- genetics KW - DNA-Directed DNA Polymerase -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733311524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+molecular+genetics&rft.atitle=mip1+containing+mutations+associated+with+mitochondrial+disease+causes+mutagenesis+and+depletion+of+mtDNA+in+Saccharomyces+cerevisiae.&rft.au=Stumpf%2C+Jeffrey+D%3BBailey%2C+Christopher+M%3BSpell%2C+Diana%3BStillwagon%2C+Matthew%3BAnderson%2C+Karen+S%3BCopeland%2C+William+C&rft.aulast=Stumpf&rft.aufirst=Jeffrey&rft.date=2010-06-01&rft.volume=19&rft.issue=11&rft.spage=2123&rft.isbn=&rft.btitle=&rft.title=Human+molecular+genetics&rft.issn=1460-2083&rft_id=info:doi/10.1093%2Fhmg%2Fddq089 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-22 N1 - Date created - 2010-05-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1183-8 [17227840] Antimicrob Agents Chemother. 2004 Apr;48(4):1300-6 [15047533] Nat Genet. 2007 Apr;39(4):540-3 [17334366] Cell Cycle. 2007 Aug 15;6(16):2048-57 [17721079] Hum Mol Genet. 2007 Nov 15;16(22):2729-39 [17725985] DNA Repair (Amst). 2007 Dec 1;6(12):1732-9 [17689152] Biochim Biophys Acta. 2007 Dec;1772(11-12):1225-35 [17980715] Annu Rev Med. 2008;59:131-46 [17892433] Arch Neurol. 2008 Jan;65(1):121-4 [18195149] Nat Genet. 2008 Apr;40(4):392-4 [18311139] Nature. 2004 May 27;429(6990):417-23 [15164064] Nucleic Acids Res. 2004;32(10):3053-64 [15181170] Annu Rev Biochem. 2004;73:293-320 [15189144] Nat Struct Mol Biol. 2004 Aug;11(8):770-6 [15258572] Nucleic Acids Res. 1984 Nov 26;12(22):8313-8 [6095195] Annu Rev Biochem. 1988;57:349-74 [3052277] Nature. 1989 May 25;339(6222):309-11 [2725645] EMBO J. 1992 Jul;11(7):2717-26 [1321035] Gene. 1995 Jul 4;160(1):105-10 [7628702] Genomics. 1996 Sep 15;36(3):449-58 [8884268] Biochemistry. 1998 Jul 21;37(29):10529-39 [9671525] J Biol Chem. 1998 Sep 11;273(37):23690-7 [9726974] Curr Opin Struct Biol. 1998 Dec;8(6):704-12 [9914251] Adv Protein Chem. 2004;69:137-65 [15588842] J Biol Chem. 2005 Sep 9;280(36):31341-6 [16024923] Arch Neurol. 2006 Jan;63(1):107-11 [16401742] Hum Mol Genet. 2006 Jan 15;15(2):363-74 [16368709] Chem Rev. 2006 Feb;106(2):383-405 [16464011] Ann Neurol. 2006 May;59(5):859-62 [16634032] Am J Hum Genet. 2006 Jun;78(6):1026-34 [16685652] Brain. 2006 Jul;129(Pt 7):1674-84 [16621917] Neuromuscul Disord. 2006 Aug;16(8):507-9 [16919951] Hum Mol Genet. 2006 Oct 1;15(19):2846-55 [16940310] Hum Mol Genet. 2006 Dec 1;15(23):3473-83 [17088268] Hum Mol Genet. 2008 Aug 15;17(16):2496-506 [18487244] PLoS Genet. 2008 Nov;4(11):e1000264 [19023402] J Biol Chem. 2009 Jul 17;284(29):19501-10 [19478085] Cell Metab. 2009 Aug;10(2):131-8 [19656491] Int J Biochem Cell Biol. 2009 Oct;41(10):1914-27 [19549572] Cell. 2009 Oct 16;139(2):312-24 [19837034] Genome Biol. 2009;10(9):R95 [19751518] J Med Genet. 2009 Nov;46(11):776-85 [19578034] Hum Mutat. 2008 Sep;29(9):E150-72 [18546365] J Biol Chem. 1999 Dec 31;274(53):38197-203 [10608893] Methods. 2000 Jan;20(1):4-17 [10610800] J Biol Chem. 2001 Oct 19;276(42):38555-62 [11504725] J Biol Chem. 2001 Nov 23;276(47):43487-90 [11579108] J Biol Chem. 2002 May 3;277(18):15225-8 [11897778] Mutagenesis. 2002 Sep;17(5):375-81 [12202624] J Biol Chem. 2002 Oct 25;277(43):40479-90 [12176989] Neurology. 2003 Apr 22;60(8):1354-6 [12707443] Eur J Hum Genet. 2003 Jul;11(7):547-9 [12825077] Sci Aging Knowledge Environ. 2003 Feb 26;2003(8):RE3 [12844548] Eukaryot Cell. 2003 Aug;2(4):809-20 [12912900] Arch Neurol. 2003 Sep;60(9):1279-84 [12975295] Hum Mutat. 2003 Dec;22(6):498-9 [14635118] Neurology. 2004 Jan 27;62(2):316-8 [14745080] Lab Invest. 2007 Apr;87(4):326-35 [17310215] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/hmg/ddq089 ER - TY - JOUR T1 - Inhibition of IkappaB kinase-beta protects dopamine neurons against lipopolysaccharide-induced neurotoxicity. AN - 733280472; 20190013 AB - Parkinson's disease (PD) is a progressive neurological disorder characterized by a selective loss of dopamine (DA) neurons in the substantia nigra (SN). Although current therapy can control symptoms of this disorder, there is no effective therapy available to halt its progression. Recently, neuroinflammation has been recognized as an important contributor to the pathogenesis of PD, and nuclear factor-kappaB (NF-kappaB) plays a key role in regulating neuroinflammation. Hence, the modulation of NF-kappaB pathway may have therapeutic potential for PD. Activation of NF-kappaB depends on the phosphorylation of its inhibitor, IkappaB, by the specific IkappaB kinase (IKK) subunit IKK-beta. Compound A (7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1, 4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride), a potent and selective inhibitor of IKK-beta, has recently been reported to provide cardioprotection through specific suppression of NF-kappaB signaling. The present study, for the first time, elucidates neuroprotective effects of compound A. Daily subcutaneous injection of compound A (1 mg/kg) for 7 days inhibited the activation of microglia induced by nigral stereotaxic injection of lipopolysaccharide (LPS) and significantly attenuated LPS-induced loss of DA neurons in the SN. In vitro mechanistic studies revealed that neuroprotective effects of compound A were mediated by 1) suppressing the activity of microglial NADPH oxidase and decreasing the production of reactive oxygen species, and 2) inhibiting NF-kappaB-mediated gene transcription of various proinflammatory mediators in microglia via IKK-beta suppression. These findings indicate that compound A afforded potent neuroprotection against LPS-induced neurodegeneration through selective inhibition of NF-kappaB activation and may be of potential benefit in the treatment of PD. JF - The Journal of pharmacology and experimental therapeutics AU - Zhang, Feng AU - Qian, Li AU - Flood, Patrick M AU - Shi, Jing-Shan AU - Hong, Jau-Shyong AU - Gao, Hui-Ming AD - Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 822 EP - 833 VL - 333 IS - 3 KW - 7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(3-piperidinyl)-1,4-dihydro-2H-pyrido(2,3-d)(1,3)oxazin-2-one KW - 0 KW - Enzyme Inhibitors KW - Indicators and Reagents KW - Interleukin-1beta KW - Lipopolysaccharides KW - Neuroprotective Agents KW - Neurotoxins KW - Nitrites KW - Oxazines KW - Pyridines KW - Tumor Necrosis Factor-alpha KW - Superoxides KW - 11062-77-4 KW - NADPH Oxidase KW - EC 1.6.3.1 KW - I-kappa B Kinase KW - EC 2.7.11.10 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Nitrites -- metabolism KW - Astrocytes -- drug effects KW - NADPH Oxidase -- antagonists & inhibitors KW - Neuroglia -- drug effects KW - Reverse Transcriptase Polymerase Chain Reaction KW - Rats KW - Superoxides -- metabolism KW - Rats, Inbred F344 KW - Blotting, Western KW - Cells, Cultured KW - Interleukin-1beta -- metabolism KW - Tumor Necrosis Factor-alpha -- metabolism KW - Immunohistochemistry KW - Microglia -- drug effects KW - Male KW - I-kappa B Kinase -- antagonists & inhibitors KW - Lipopolysaccharides -- antagonists & inhibitors KW - Neurons -- drug effects KW - Dopamine -- physiology KW - Lipopolysaccharides -- toxicity KW - Enzyme Inhibitors -- pharmacology KW - Dopamine -- metabolism KW - Oxazines -- pharmacology KW - Pyridines -- pharmacology KW - Neurotoxins -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733280472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Inhibition+of+IkappaB+kinase-beta+protects+dopamine+neurons+against+lipopolysaccharide-induced+neurotoxicity.&rft.au=Zhang%2C+Feng%3BQian%2C+Li%3BFlood%2C+Patrick+M%3BShi%2C+Jing-Shan%3BHong%2C+Jau-Shyong%3BGao%2C+Hui-Ming&rft.aulast=Zhang&rft.aufirst=Feng&rft.date=2010-06-01&rft.volume=333&rft.issue=3&rft.spage=822&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.110.165829 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-11 N1 - Date created - 2010-05-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Leukoc Biol. 2005 Jul;78(1):210-9 [15845648] J Immunol. 2009 May 15;182(10):6410-7 [19414794] Immunol Rev. 2006 Apr;210:171-86 [16623771] Biochem Biophys Res Commun. 2006 Nov 17;350(2):322-8 [17010309] Biochem Soc Trans. 2006 Nov;34(Pt 5):837-41 [17052210] Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):781-802 [16823625] FASEB J. 2006 Dec;20(14):2496-511 [17142799] Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2248-53 [17675566] Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18754-9 [18000063] J Neuroimmunol. 2007 Dec;192(1-2):89-98 [17976742] Trends Immunol. 2008 Aug;29(8):357-65 [18599350] Genes Dev. 2008 Aug 1;22(15):2093-101 [18676814] Brain. 2008 Nov;131(Pt 11):3019-33 [18819987] J Thorac Cardiovasc Surg. 2008 Nov;136(5):1274-9 [19026814] Free Radic Biol Med. 2008 Dec 15;45(12):1695-704 [18852043] Lancet Neurol. 2009 Apr;8(4):382-97 [19296921] Annu Rev Immunol. 2009;27:119-45 [19302036] Cell. 2009 Apr 3;137(1):47-59 [19345186] Oncogene. 1999 Nov 22;18(49):6867-74 [10602462] J Pharmacol Exp Ther. 2000 May;293(2):607-17 [10773035] J Pharmacol Exp Ther. 2000 Oct;295(1):125-32 [10991969] J Clin Invest. 2001 Jan;107(1):13-9 [11134172] J Biol Chem. 2001 Nov 30;276(48):44527-33 [11551948] J Neurosci. 2002 Feb 1;22(3):782-90 [11826108] Trends Pharmacol Sci. 2003 Aug;24(8):395-401 [12915048] FASEB J. 2003 Oct;17(13):1954-6 [12897068] Trends Biochem Sci. 2004 Feb;29(2):72-9 [15102433] Eur J Neurosci. 2004 Jun;19(12):3375-81 [15217394] Neurology. 1988 Aug;38(8):1285-91 [3399080] Science. 1996 Nov 1;274(5288):787-9 [8864120] Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7531-6 [9207126] J Exp Med. 1999 Jun 7;189(11):1839-45 [10359587] Br J Pharmacol. 2005 May;145(2):178-92 [15753951] Neurotox Res. 2005;7(3):193-202 [15897154] J Cell Sci. 2005 Oct 15;118(Pt 20):4589-92 [16219681] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.110.165829 ER - TY - JOUR T1 - Chlamydia pneumoniae infection and risk for lung cancer. AN - 733250482; 20501758 AB - We evaluated the relationship of Chlamydia pneumoniae infection with prospective lung cancer risk using traditional serologic markers [microimmunoflourescence (MIF) IgG and IgA antibodies] and Chlamydia heat shock protein-60 (CHSP-60) antibodies, a marker for chronic chlamydial infection. We conducted a nested case-control study (593 lung cancers and 671 controls) within the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (N = 77,464). Controls were matched to cases by age, sex, randomization year, follow-up time, and smoking (pack-years of smoking, time since quitting). We assessed C. pneumoniae seropositivity and endpoint antibody titers (IgG and IgA against C. pneumoniae elementary bodies and IgG against CHSP-60). C. pneumoniae seropositivity by microimmunoflourescence IgG or IgA antibodies was not associated with lung cancer [odds ratio of 0.88 and 95% confidence interval (95% CI) of 0.69-1.13 for IgG; odds ratio of 0.98 and 95% CI of 0.75-1.27 for IgA]. In contrast, individuals seropositive for CHSP-60 IgG antibodies had significantly increased lung cancer risk (odds ratio, 1.30; 95% CI, 1.02-1.67), and risk increased with increasing antibody titers (P trend = 0.006). CHSP-60-related risk did not differ significantly by lung cancer histology, follow-up time, or smoking. CHSP-60 seropositivity was associated with increased risk 2 to 5 years before lung cancer diagnosis (odds ratio, 1.77; 95% CI, 1.16-2.71; P trend = 0.006), thus arguing against reverse causality. CHSP-60 seropositivity and elevated antibody titers were associated with significantly increased risk for subsequent lung cancer, supporting an etiologic role for C. pneumoniae infection in lung carcinogenesis. Our results highlight the potential for lung cancer risk reduction through treatments targeted toward C. pneumoniae infections and chronic pulmonary inflammation. Copyright 2010 AACR. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Chaturvedi, Anil K AU - Gaydos, Charlotte A AU - Agreda, Patricia AU - Holden, Jeffrey P AU - Chatterjee, Nilanjan AU - Goedert, James J AU - Caporaso, Neil E AU - Engels, Eric A AD - Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA. chaturva@mail.nih.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 1498 EP - 1505 VL - 19 IS - 6 KW - Antibodies KW - 0 KW - Chaperonin 60 KW - Immunoglobulin A KW - Immunoglobulin G KW - Index Medicus KW - Humans KW - Immunoglobulin A -- immunology KW - Aged KW - Immunoglobulin G -- immunology KW - Antibodies -- blood KW - Prospective Studies KW - Risk Factors KW - Case-Control Studies KW - Middle Aged KW - Fluorescent Antibody Technique KW - Chaperonin 60 -- immunology KW - Female KW - Male KW - Chlamydophila Infections -- blood KW - Lung Neoplasms -- blood KW - Lung Neoplasms -- microbiology KW - Chlamydophila pneumoniae -- isolation & purification KW - Chlamydophila Infections -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733250482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Chlamydia+pneumoniae+infection+and+risk+for+lung+cancer.&rft.au=Chaturvedi%2C+Anil+K%3BGaydos%2C+Charlotte+A%3BAgreda%2C+Patricia%3BHolden%2C+Jeffrey+P%3BChatterjee%2C+Nilanjan%3BGoedert%2C+James+J%3BCaporaso%2C+Neil+E%3BEngels%2C+Eric+A&rft.aulast=Chaturvedi&rft.aufirst=Anil&rft.date=2010-06-01&rft.volume=19&rft.issue=6&rft.spage=1498&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=1538-7755&rft_id=info:doi/10.1158%2F1055-9965.EPI-09-1261 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-15 N1 - Date created - 2010-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-09-1261 ER - TY - JOUR T1 - A phase I clinical study of high dose ketoconazole plus weekly docetaxel for metastatic castration resistant prostate cancer. AN - 733134815; 20399458 AB - This phase I study of high dose ketoconazole and docetaxel was designed against castration resistant prostate cancer to determine the maximum tolerated doses, side effects, and pharmacokinetic interaction of co-administered docetaxel and ketoconazole. Patients with metastatic castration resistant prostate cancer received weekly docetaxel for 3 of every 4 weeks plus daily ketoconazole. Pharmacokinetic studies were performed on day 1 (docetaxel alone) and day 16 (after ketoconazole). The study enrolled 42 patients at 9 different dose levels. The combination regimens investigated included docetaxel weekly, increasing from 5 to 43 mg/m(2), with starting doses of 600, 800 or 1,200 mg ketoconazole daily. Decreases in prostate specific antigen of 50% or greater were seen in 62% of patients. Of 25 patients with soft tissue disease 7 (28%) had a partial response. Median overall survival was 22.8 months and was significantly greater in docetaxel naïve patients than in patients pretreated with docetaxel (36.8 vs 10.3 months, p = 0.0001). The most frequently observed adverse events were anemia, edema, fatigue, diarrhea, nausea, sensory neuropathy and elevated liver function tests. The fractional change in docetaxel clearance correlated significantly with ketoconazole exposure (p <0.01). Concomitant ketoconazole increased docetaxel exposure 2.6-fold with 1,200 mg daily, 1.6-fold with 800 mg daily and approximately 1.3 to 1.5-fold with 600 mg daily. Combination regimens using 600 mg ketoconazole daily were fairly well tolerated and the maximum tolerated dose of docetaxel was 32 mg/m(2). Results suggest that the combination has significant antitumor activity in castration resistant prostate cancer. The long survival in the docetaxel naïve cohort warrants additional, larger trials of docetaxel with ketoconazole or possibly CYP17A1 inhibitors such as abiraterone. Copyright 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. JF - The Journal of urology AU - Figg, William D AU - Woo, Sukyung AU - Zhu, Wenhui AU - Chen, Xiaohong AU - Ajiboye, A Seun AU - Steinberg, Seth M AU - Price, Douglas K AU - Wright, John J AU - Parnes, Howard L AU - Arlen, Philip M AU - Gulley, James L AU - Dahut, William L AD - Clinical Pharmacology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. wdfigg@helix.nih.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 2219 EP - 2226 VL - 183 IS - 6 KW - Androgen Antagonists KW - 0 KW - Antineoplastic Agents KW - Taxoids KW - docetaxel KW - 15H5577CQD KW - Ketoconazole KW - R9400W927I KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Treatment Failure KW - Drug Interactions KW - Drug Administration Schedule KW - Androgen Antagonists -- therapeutic use KW - Humans KW - Neoplasm Metastasis KW - Male KW - Taxoids -- pharmacokinetics KW - Ketoconazole -- pharmacokinetics KW - Prostatic Neoplasms -- pathology KW - Antineoplastic Agents -- administration & dosage KW - Ketoconazole -- therapeutic use KW - Antineoplastic Agents -- pharmacokinetics KW - Prostatic Neoplasms -- drug therapy KW - Taxoids -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733134815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=A+phase+I+clinical+study+of+high+dose+ketoconazole+plus+weekly+docetaxel+for+metastatic+castration+resistant+prostate+cancer.&rft.au=Figg%2C+William+D%3BWoo%2C+Sukyung%3BZhu%2C+Wenhui%3BChen%2C+Xiaohong%3BAjiboye%2C+A+Seun%3BSteinberg%2C+Seth+M%3BPrice%2C+Douglas+K%3BWright%2C+John+J%3BParnes%2C+Howard+L%3BArlen%2C+Philip+M%3BGulley%2C+James+L%3BDahut%2C+William+L&rft.aulast=Figg&rft.aufirst=William&rft.date=2010-06-01&rft.volume=183&rft.issue=6&rft.spage=2219&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=1527-3792&rft_id=info:doi/10.1016%2Fj.juro.2010.02.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-03 N1 - Date created - 2010-05-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Cancer Res. 2005 Oct 15;11(20):7398-404 [16243813] Urology. 2005 Jun;65(6 Suppl):8-12 [15939077] Cancer Biol Ther. 2006 Jul;5(7):833-9 [16775418] Clin Cancer Res. 2006 Oct 1;12(19):5786-93 [17020985] Cochrane Database Syst Rev. 2006;(4):CD005247 [17054249] CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66 [17237035] Eur J Clin Pharmacol. 2007 May;63(5):479-83 [17345073] Cancer Chemother Pharmacol. 2007 Sep;60(4):569-79 [17256132] Antimicrob Agents Chemother. 2007 Aug;51(8):2982-4 [17517848] Urol Oncol. 2007 Sep-Oct;25(5):413-9 [17826663] J Clin Oncol. 2008 Jan 10;26(2):242-5 [18182665] Cancer Chemother Pharmacol. 2008 Jul;62(2):243-51 [17909805] Lancet. 2008 May 17;371(9625):1710-21 [18486743] Clin Cancer Res. 2008 Jun 1;14(11):3312-8 [18519758] Clin Cancer Res. 2008 Jul 15;14(14):4543-9 [18628469] Clin Pharmacol Ther. 2009 Feb;85(2):155-63 [18509327] J Clin Oncol. 2009 Jun 10;27(17):2758-65 [19403886] J Urol. 2000 Mar;163(3):1022-6 [10688042] Urology. 2002 Sep;60(3 Suppl 1):87-92; discussion 93 [12231058] J Clin Oncol. 2003 Apr 1;21(7):1232-7 [12663709] Cancer. 2003 Nov 1;98(9):1855-62 [14584067] J Clin Oncol. 2004 Mar 15;22(6):1025-33 [15020604] Clin Pharmacol Ther. 2004 May;75(5):448-54 [15116057] Biopharm Drug Dispos. 2004 Jul;25(5):203-9 [15248189] N Engl J Med. 2004 Oct 7;351(15):1502-12 [15470213] N Engl J Med. 2004 Oct 7;351(15):1513-20 [15470214] J Antimicrob Chemother. 1981 Oct;8(4):299-304 [6271723] J Antimicrob Chemother. 1983 Aug;12(2):185-8 [6311786] Antimicrob Agents Chemother. 1986 Aug;30(2):206-10 [3767339] J Urol. 1987 May;137(5):905-8 [2952808] Urology. 1988 Feb;31(2):132-4 [3341098] J Clin Oncol. 1989 Aug;7(8):1093-8 [2474059] Cancer Surv. 1993;17:305-13 [7907950] J Clin Oncol. 1994 Apr;12(4):683-8 [7512126] J Pharmacol Exp Ther. 1996 Apr;277(1):321-32 [8613937] Cancer Res. 1996 Mar 15;56(6):1296-302 [8640817] Cancer Lett. 1997 Feb 26;113(1-2):111-6 [9065809] Cancer Chemother Pharmacol. 1998;42 Suppl:S50-3 [9750029] Drug Metab Dispos. 1999 Feb;27(2):180-7 [9929500] J Urol. 2005 Mar;173(3):790-6 [15711271] Cancer. 2006 Jun 1;106(11):2459-65 [16615097] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.juro.2010.02.020 ER - TY - JOUR T1 - C-reactive protein and risk of lung cancer. AN - 733109338; 20421535 AB - Chronic inflammation could play a role in lung carcinogenesis, underscoring the potential for lung cancer prevention and screening. We investigated the association of circulating high-sensitivity C-reactive protein (CRP, an inflammation biomarker) and CRP single nucleotide polymorphisms (SNPs) with prospective lung cancer risk. We conducted a nested case-control study of 592 lung cancer patients and 670 controls with available prediagnostic serum and 378 patients and 447 controls with DNA within the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (N = 77,464). Controls were matched to patients on age, sex, entry year, follow-up time, and smoking. We measured CRP levels in baseline serum samples and genotyped five common CRP SNPs. Elevated CRP levels were associated with increased lung cancer risk (odds ratio [OR], 1.98; 95% CI, 1.35 to 2.89; P-trend or = 5.6 mg/L] v Q1 [< 1.0 mg/L]). The CRP association did not differ significantly by histology, follow-up time, or smoking status, but was most apparent for squamous cell carcinomas (OR, 2.92; 95% CI, 1.30 to 6.54), 2 to 5 years before lung cancer diagnosis (OR, 2.33; 95% CI, 1.24 to 4.39), and among former smokers (OR, 2.48; 95% CI, 1.53 to 4.03) and current smokers (OR, 1.90; 95% CI, 1.06 to 3.41). Although CRP SNPs and haplotypes were associated with CRP levels, they were not associated with lung cancer risk. Ten-year standardized absolute risks of lung cancer were higher with elevated CRP levels among former smokers (Q4: 2.55%; 95% CI, 1.98% to 3.27% v Q1: 1.39%; 95% CI, 1.07% to 1.81%) and current smokers (Q4: 7.37%; 95% CI, 5.81% to 9.33% v Q1: 4.03%; 95% CI, 3.01% to 5.40%). Elevated CRP levels are associated with subsequently increased lung cancer risk, suggesting an etiologic role for chronic pulmonary inflammation in lung carcinogenesis. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Chaturvedi, Anil K AU - Caporaso, Neil E AU - Katki, Hormuzd A AU - Wong, Hui-Lee AU - Chatterjee, Nilanjan AU - Pine, Sharon R AU - Chanock, Stephen J AU - Goedert, James J AU - Engels, Eric A AD - Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., Rockville, MD 20852, USA. chaturva@mail.nih.gov Y1 - 2010/06/01/ PY - 2010 DA - 2010 Jun 01 SP - 2719 EP - 2726 VL - 28 IS - 16 KW - Biomarkers, Tumor KW - 0 KW - C-Reactive Protein KW - 9007-41-4 KW - Index Medicus KW - Reference Values KW - Odds Ratio KW - Neoplasm Staging KW - Humans KW - Linear Models KW - Aged KW - Smoking -- epidemiology KW - Comorbidity KW - Risk Assessment KW - Age Distribution KW - Logistic Models KW - Cohort Studies KW - Case-Control Studies KW - Confidence Intervals KW - Incidence KW - Middle Aged KW - Follow-Up Studies KW - Sex Distribution KW - Male KW - Female KW - Survival Analysis KW - Biomarkers, Tumor -- metabolism KW - Biomarkers, Tumor -- genetics KW - C-Reactive Protein -- genetics KW - Lung Neoplasms -- epidemiology KW - Carcinoma, Squamous Cell -- epidemiology KW - Lung Neoplasms -- blood KW - Carcinoma, Squamous Cell -- pathology KW - Carcinoma, Squamous Cell -- blood KW - C-Reactive Protein -- metabolism KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733109338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=C-reactive+protein+and+risk+of+lung+cancer.&rft.au=Chaturvedi%2C+Anil+K%3BCaporaso%2C+Neil+E%3BKatki%2C+Hormuzd+A%3BWong%2C+Hui-Lee%3BChatterjee%2C+Nilanjan%3BPine%2C+Sharon+R%3BChanock%2C+Stephen+J%3BGoedert%2C+James+J%3BEngels%2C+Eric+A&rft.aulast=Chaturvedi&rft.aufirst=Anil&rft.date=2010-06-01&rft.volume=28&rft.issue=16&rft.spage=2719&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2009.27.0454 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-21 N1 - Date created - 2010-05-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Control Clin Trials. 2000 Dec;21(6 Suppl):273S-309S [11189684] J Clin Oncol. 2009 May 1;27(13):2217-24 [19289618] Science. 2002 Jun 21;296(5576):2225-9 [12029063] Nature. 2002 Dec 19-26;420(6917):860-7 [12490959] J Natl Cancer Inst. 2003 Mar 19;95(6):470-8 [12644540] Cancer Causes Control. 2003 May;14(4):327-34 [12846363] Clin Lung Cancer. 2003 Jul;5(1):46-62 [14596704] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] Carcinogenesis. 2004 Feb;25(2):229-35 [14604894] Thorax. 2004 Jul;59(7):574-80 [15223864] Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):773-8 [15824142] J Clin Oncol. 2005 May 10;23(14):3175-85 [15886304] Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2413-8 [16214925] Nat Clin Pract Cardiovasc Med. 2005 Jan;2(1):29-36; quiz 58 [16265340] Dis Markers. 2005;21(3):157-65 [16276011] Lung Cancer. 2005 Dec;50(3):291-7 [16122836] Mutat Res. 2005 Dec 30;592(1-2):147-54 [16054167] Am J Respir Crit Care Med. 2006 Mar 1;173(5):535-9 [16339918] Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):381-4 [16492932] Proc Am Thorac Soc. 2006 Aug;3(6):535-7 [16921139] Int J Cancer. 2007 Jan 1;120(1):1-6 [17058200] J Clin Oncol. 2006 Nov 20;24(33):5216-22 [17114654] Thorax. 2007 Jan;62(1):51-6 [16928722] JAMA. 2007 Feb 14;297(6):611-9 [17299196] J Natl Cancer Inst. 2007 May 2;99(9):715-26 [17470739] Cancer Res. 2007 Jul 1;67(13):6520-7 [17596594] J Epidemiol Community Health. 2007 Sep;61(9):824-33 [17699539] Expert Rev Anticancer Ther. 2007 Oct;7(10):1405-21 [17944566] Curr Atheroscler Rep. 2007 Sep;9(3):195-203 [18241613] Curr Opin Pulm Med. 2008 Mar;14(2):115-21 [18303420] Expert Rev Anticancer Ther. 2008 Apr;8(4):605-15 [18402527] N Engl J Med. 2008 Oct 30;359(18):1897-908 [18971492] N Engl J Med. 2008 Oct 30;359(18):1953-5 [18971498] Arch Intern Med. 2008 Nov 24;168(21):2326-32; discussion 2332 [19029496] Circulation. 2008 Nov 25;118(22):2243-51, 4p following 2251 [18997194] Am J Respir Crit Care Med. 2009 Mar 1;179(5):375-82 [19096002] Exp Lung Res. 2001 Apr-May;27(3):197-216 [11293324] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1200/JCO.2009.27.0454 ER - TY - JOUR T1 - Oral human papillomavirus in healthy individuals: a systematic review of the literature. AN - 733106014; 20081557 AB - Human papillomavirus type 16 (HPV16) is a common infection in the anogenital tract. HPV16 DNA detected in oral specimens has recently been identified as a risk factor for some oropharyngeal cancers. The reported prevalence of oral HPV infection from individual studies is highly variable. We systematically reviewed and abstracted data from published studies (n = 18) that detected oral HPV DNA in 4581 cancer-free subjects to determine the pooled prevalence (and 95% confidence intervals [CI]) of HPV16, carcinogenic HPV, and any HPV. 1.3% (95% CI: 1.0-1.7%) of 3977 healthy subjects had oral HPV16, 3.5% (95% CI: 3.0-4.1) of 4441 subjects had carcinogenic HPV, and 4.5% (95% CI: 3.9-5.1) of 4070 subjects were positive for any HPV. Oral HPV16 accounted for 28% of all HPV detected in the oral region. Men (47 of 1017) and women (117 of 3690) had nearly exactly the same prevalence of any oral HPV detected (4.6% vs. 4.4%, respectively). HPV-16, a common anogenital infection, was rarely detected in oral specimens. However, a small but noteworthy proportion of healthy individuals have oral HPV infections with types known to cause cancer in the oral region. JF - Sexually transmitted diseases AU - Kreimer, Aimée R AU - Bhatia, Rohini K AU - Messeguer, Andrea L AU - González, Paula AU - Herrero, Rolando AU - Giuliano, Anna R AD - National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. kreimera@mail.nih.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 386 EP - 391 VL - 37 IS - 6 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Young Adult KW - Polymerase Chain Reaction KW - DNA, Viral -- analysis KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Prevalence KW - Mouth Diseases -- virology KW - Tumor Virus Infections -- virology KW - Mouth -- virology KW - Oropharyngeal Neoplasms -- virology KW - Human papillomavirus 16 -- isolation & purification KW - Tumor Virus Infections -- epidemiology KW - Papillomavirus Infections -- virology KW - Oropharyngeal Neoplasms -- epidemiology KW - Mouth Diseases -- epidemiology KW - Papillomaviridae -- genetics KW - Papillomavirus Infections -- epidemiology KW - Papillomaviridae -- classification KW - Papillomaviridae -- isolation & purification KW - Human papillomavirus 16 -- genetics KW - Human papillomavirus 16 -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733106014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+transmitted+diseases&rft.atitle=Oral+human+papillomavirus+in+healthy+individuals%3A+a+systematic+review+of+the+literature.&rft.au=Kreimer%2C+Aim%C3%A9e+R%3BBhatia%2C+Rohini+K%3BMesseguer%2C+Andrea+L%3BGonz%C3%A1lez%2C+Paula%3BHerrero%2C+Rolando%3BGiuliano%2C+Anna+R&rft.aulast=Kreimer&rft.aufirst=Aim%C3%A9e&rft.date=2010-06-01&rft.volume=37&rft.issue=6&rft.spage=386&rft.isbn=&rft.btitle=&rft.title=Sexually+transmitted+diseases&rft.issn=1537-4521&rft_id=info:doi/10.1097%2FOLQ.0b013e3181c94a3b LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-03 N1 - Date created - 2010-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/OLQ.0b013e3181c94a3b ER - TY - JOUR T1 - Insufficient luteinizing hormone-induced intracellular signaling disrupts ovulation in preovulatory follicles lacking estrogen receptor-{beta}. AN - 733088534; 20378682 AB - Gonadotropin-stimulated estrogen receptor-beta (ERbeta)-null preovulatory follicles exhibit submaximal estradiol production, insufficient acquisition of LH receptor, and attenuated expression of essential ovulatory genes. These observations lead to low ovulatory rates compared with wild-type (WT) follicles. We hypothesize that insufficient LH receptor results in reduced cAMP production after an ovulatory stimulus. Individual preantral follicles were cultured with FSH for 4 d and then induced to ovulate with a single dose of human chorionic gonadotropin (hCG). cAMP levels 1 h after hCG were 50% lower in ERbeta-null than WT follicles. To determine whether the lack of LH receptor, and resulting lack of cAMP, could be bypassed by direct activation of adenylyl cyclase, WT and ERbeta-null follicles were induced to ovulate with forskolin. Ten micromolar forskolin doubled the ovulatory rate of ERbeta-null follicles compared with treatment with hCG ( approximately 50 vs. 25%, respectively). In WT follicles, 10 microm forskolin reduced the ovulation rate compared with hCG (14 vs. 83%, respectively), indicating that high doses of forskolin inhibited WT ovulation. A 10 microm concentration of forskolin induced cAMP levels in ERbeta-null follicles that were comparable to levels produced in WT follicles after hCG and either partially or completely rescued the attenuated expression of LH-responsive genes. These data indicate that direct activation of adenylyl cyclase, resulting in increased production of cAMP, partially rescues the ovulatory response of ERbeta-null follicles, suggesting that insufficient LH receptor and low cAMP levels contribute to their poor ovulatory rates. We also determined that ERbeta-null ovaries exhibit an alteration in the activation of ERK1/2. Our evaluation of the ERbeta-null ovarian phenotype indicates that ERbeta plays a role in facilitating folliculogenesis. We show that expression of ERbeta in preovulatory follicles is required for adequate cAMP production and propose that an optimal level of cAMP is required for hCG-stimulated ovulation. JF - Endocrinology AU - Rodriguez, Karina F AU - Couse, John F AU - Jayes, Friederike L AU - Hamilton, Katherine J AU - Burns, Katherine A AU - Taniguchi, Fuminori AU - Korach, Kenneth S AD - Director, Environmental Disease Medicine Program, Chief, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, North Carolina 27709, USA. korach@niehs.nih.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 2826 EP - 2834 VL - 151 IS - 6 KW - Chorionic Gonadotropin KW - 0 KW - Estrogen Receptor beta KW - Colforsin KW - 1F7A44V6OU KW - Luteinizing Hormone KW - 9002-67-9 KW - Cyclic AMP KW - E0399OZS9N KW - Mitogen-Activated Protein Kinase 1 KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 3 KW - Abridged Index Medicus KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Humans KW - Mice KW - Phosphorylation -- drug effects KW - Mitogen-Activated Protein Kinase 3 -- metabolism KW - Blotting, Western KW - Colforsin -- pharmacology KW - Mice, Mutant Strains KW - Chorionic Gonadotropin -- pharmacology KW - Mitogen-Activated Protein Kinase 1 -- metabolism KW - Cyclic AMP -- metabolism KW - Organ Culture Techniques KW - Female KW - Male KW - Ovulation -- drug effects KW - Ovarian Follicle -- metabolism KW - Luteinizing Hormone -- pharmacology KW - Signal Transduction -- drug effects KW - Estrogen Receptor beta -- physiology KW - Ovarian Follicle -- drug effects KW - Estrogen Receptor beta -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733088534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Insufficient+luteinizing+hormone-induced+intracellular+signaling+disrupts+ovulation+in+preovulatory+follicles+lacking+estrogen+receptor-%7Bbeta%7D.&rft.au=Rodriguez%2C+Karina+F%3BCouse%2C+John+F%3BJayes%2C+Friederike+L%3BHamilton%2C+Katherine+J%3BBurns%2C+Katherine+A%3BTaniguchi%2C+Fuminori%3BKorach%2C+Kenneth+S&rft.aulast=Rodriguez&rft.aufirst=Karina&rft.date=2010-06-01&rft.volume=151&rft.issue=6&rft.spage=2826&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=1945-7170&rft_id=info:doi/10.1210%2Fen.2009-1446 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-30 N1 - Date created - 2010-05-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Endocrinol. 2001 Feb;15(2):209-18 [11158328] Mol Endocrinol. 2009 Jul;23(7):955-65 [19324971] Nucleic Acids Res. 2001 May 1;29(9):e45 [11328886] Hum Reprod. 2003 Feb;18(2):314-22 [12571167] Science. 2004 Jan 30;303(5658):682-4 [14726596] Endocrinology. 1976 Jul;99(1):185-97 [939193] Biol Reprod. 1985 Jun;32(5):1038-50 [2990583] Endocrinology. 1985 Sep;117(3):1156-61 [2990868] Hum Reprod. 1990 Jul;5(5):561-4 [2118544] Mol Endocrinol. 1990 Dec;4(12):1856-65 [2127956] Endocrinology. 1993 Aug;133(2):770-9 [8393774] Hum Reprod. 1994 Feb;9(2):188-91 [8027271] Endocrinology. 1995 Apr;136(4):1549-58 [7895665] Recent Prog Horm Res. 1995;50:223-54 [7740159] Biochem Soc Trans. 1995 Nov;23(4):929-35 [8654869] Endocrinology. 1997 Nov;138(11):4613-21 [9348186] Endocr Rev. 1997 Dec;18(6):739-73 [9408742] Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15677-82 [9861029] Endocrinology. 2005 Jun;146(6):2817-26 [15731357] Endocrinology. 2005 Aug;146(8):3247-62 [15831568] Mol Endocrinol. 2006 Apr;20(4):715-23 [16051667] Mol Endocrinol. 2006 Jun;20(6):1352-65 [16543407] FASEB J. 2007 Feb;21(2):586-95 [17158782] FASEB J. 2007 Jun;21(8):1893-901 [17341680] Mol Endocrinol. 2008 Apr;22(4):924-36 [18187604] Science. 2009 May 15;324(5929):938-41 [19443782] Mol Reprod Dev. 2009 Aug;76(8):733-50 [19484750] Endocr Rev. 2002 Apr;23(2):141-74 [11943741] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/en.2009-1446 ER - TY - JOUR T1 - Ambiguities in applying traditional Limulus Amebocyte Lysate tests to quantify endotoxin in nanoparticle formulations AN - 1034824460; 17053346 AB - Nanotechnology is finding increasing application in biology and medicine. As with other pharmaceutical formulations and medical devices intended for use in animals and human patients, contamination of nanoparticles with bacterial endotoxins should be thoroughly investigated before preclinical in vitro and in vivo characterization. Traditional methods to study endotoxin contamination include the in vitro quantitative Limulus Amebocyte Lysate test and the in vivo qualitative rabbit pyrogen test. Both of these tests have a long history of use for traditional pharmaceuticals and medical devices and are routinely used in drug development. Here we report that nanoparticles often interfere with these traditional endotoxin detection tests and suggest approaches to detect and overcome such interferences. JF - Nanomedicine AU - Dobrovolskaia, Marina A AU - Neun, Barry W AU - Clogston, Jeffrey D AU - Ding, Hui AU - Ljubimova, Julia AU - McNeil, Scott E AD - super(1)Nanotechnology Characterization Laboratory, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD 21702, USA, marina@mail.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 555 EP - 562 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 5 IS - 4 SN - 1743-5889, 1743-5889 KW - Biotechnology and Bioengineering Abstracts KW - Amebocytes KW - Contamination KW - Drug development KW - Endotoxins KW - Pharmaceuticals KW - Pyrogens KW - nanoparticles KW - nanotechnology KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034824460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanomedicine&rft.atitle=Ambiguities+in+applying+traditional+Limulus+Amebocyte+Lysate+tests+to+quantify+endotoxin+in+nanoparticle+formulations&rft.au=Dobrovolskaia%2C+Marina+A%3BNeun%2C+Barry+W%3BClogston%2C+Jeffrey+D%3BDing%2C+Hui%3BLjubimova%2C+Julia%3BMcNeil%2C+Scott+E&rft.aulast=Dobrovolskaia&rft.aufirst=Marina&rft.date=2010-06-01&rft.volume=5&rft.issue=4&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Nanomedicine&rft.issn=17435889&rft_id=info:doi/10.2217%2Fnnm.10.29 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Number of references - 24 N1 - Last updated - 2012-09-10 N1 - SubjectsTermNotLitGenreText - Amebocytes; Endotoxins; Pyrogens; Contamination; Pharmaceuticals; Drug development; nanoparticles; nanotechnology DO - http://dx.doi.org/10.2217/nnm.10.29 ER - TY - CPAPER T1 - Building eHealth Capacity: Cry Havoc! and Let Loose Our Students T2 - 2010 Annual Canadian Society of Telehealth Conference (e-Health 2010) AN - 754255049; 5808774 JF - 2010 Annual Canadian Society of Telehealth Conference (e-Health 2010) AU - Covvey, Dominic AU - Fenton, Shirley AU - Gardner, Alison AU - Gardner, Neil AU - Kim, Julie AU - Ritz, Derek Y1 - 2010/05/30/ PY - 2010 DA - 2010 May 30 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754255049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Canadian+Society+of+Telehealth+Conference+%28e-Health+2010%29&rft.atitle=Building+eHealth+Capacity%3A+Cry+Havoc%21+and+Let+Loose+Our+Students&rft.au=Covvey%2C+Dominic%3BFenton%2C+Shirley%3BGardner%2C+Alison%3BGardner%2C+Neil%3BKim%2C+Julie%3BRitz%2C+Derek&rft.aulast=Covvey&rft.aufirst=Dominic&rft.date=2010-05-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Canadian+Society+of+Telehealth+Conference+%28e-Health+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.e-healthconference.com/PDFs/eHealth2010_Concurrent_Sessions LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Harmonizing the Competency Cacophony T2 - 2010 Annual Canadian Society of Telehealth Conference (e-Health 2010) AN - 754231896; 5808771 JF - 2010 Annual Canadian Society of Telehealth Conference (e-Health 2010) AU - Covvey, Dominic AU - Fenton, Shirley AU - Sabaratnam, Sandra AU - Chanda, Noemi Y1 - 2010/05/30/ PY - 2010 DA - 2010 May 30 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754231896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Canadian+Society+of+Telehealth+Conference+%28e-Health+2010%29&rft.atitle=Harmonizing+the+Competency+Cacophony&rft.au=Covvey%2C+Dominic%3BFenton%2C+Shirley%3BSabaratnam%2C+Sandra%3BChanda%2C+Noemi&rft.aulast=Covvey&rft.aufirst=Dominic&rft.date=2010-05-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Canadian+Society+of+Telehealth+Conference+%28e-Health+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.e-healthconference.com/PDFs/eHealth2010_Concurrent_Sessions LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - An Instrument for Communicating Human Resources Needs and Capabilities T2 - 2010 Annual Canadian Society of Telehealth Conference (e-Health 2010) AN - 754231868; 5808768 JF - 2010 Annual Canadian Society of Telehealth Conference (e-Health 2010) AU - Covvey, Dominic AU - Fenton, Shirley AU - Roach, Richard Y1 - 2010/05/30/ PY - 2010 DA - 2010 May 30 KW - Human resources KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754231868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Canadian+Society+of+Telehealth+Conference+%28e-Health+2010%29&rft.atitle=An+Instrument+for+Communicating+Human+Resources+Needs+and+Capabilities&rft.au=Covvey%2C+Dominic%3BFenton%2C+Shirley%3BRoach%2C+Richard&rft.aulast=Covvey&rft.aufirst=Dominic&rft.date=2010-05-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Canadian+Society+of+Telehealth+Conference+%28e-Health+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.e-healthconference.com/PDFs/eHealth2010_Concurrent_Sessions LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Exposure to endocrine disrupters and testis cancer risks T2 - 2010 Gordon Research Conference on Environmental Endocrine Disruptors AN - 754229594; 5775998 JF - 2010 Gordon Research Conference on Environmental Endocrine Disruptors AU - Cook, Michael Y1 - 2010/05/30/ PY - 2010 DA - 2010 May 30 KW - Cancer KW - Endocrine disruptors KW - Testes KW - Endocrinology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754229594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Environmental+Endocrine+Disruptors&rft.atitle=Exposure+to+endocrine+disrupters+and+testis+cancer+risks&rft.au=Cook%2C+Michael&rft.aulast=Cook&rft.aufirst=Michael&rft.date=2010-05-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Environmental+Endocrine+Disruptors&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=envendo LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Trafficking and Function of Pulmonary Dendritic Cells T2 - 2010 Gordon Research Conference on Chemotactic Cytokines AN - 754226978; 5776011 JF - 2010 Gordon Research Conference on Chemotactic Cytokines AU - Cook, Don Y1 - 2010/05/30/ PY - 2010 DA - 2010 May 30 KW - Trafficking KW - Lung KW - Dendritic cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754226978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Chemotactic+Cytokines&rft.atitle=Trafficking+and+Function+of+Pulmonary+Dendritic+Cells&rft.au=Cook%2C+Don&rft.aulast=Cook&rft.aufirst=Don&rft.date=2010-05-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Chemotactic+Cytokines&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=chemotac LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Teasing Disease from Chemokinese T2 - 2010 Gordon Research Conference on Chemotactic Cytokines AN - 754207039; 5775595 JF - 2010 Gordon Research Conference on Chemotactic Cytokines AU - Murphy, Phil Y1 - 2010/05/30/ PY - 2010 DA - 2010 May 30 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754207039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Chemotactic+Cytokines&rft.atitle=Teasing+Disease+from+Chemokinese&rft.au=Murphy%2C+Phil&rft.aulast=Murphy&rft.aufirst=Phil&rft.date=2010-05-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Chemotactic+Cytokines&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=chemotac LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Ocular degeneration in FPR deficient mice T2 - 2010 Gordon Research Conference on Chemotactic Cytokines AN - 754205449; 5775601 JF - 2010 Gordon Research Conference on Chemotactic Cytokines AU - Gao, Ji Y1 - 2010/05/30/ PY - 2010 DA - 2010 May 30 KW - Mice KW - Degeneration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754205449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Chemotactic+Cytokines&rft.atitle=Ocular+degeneration+in+FPR+deficient+mice&rft.au=Gao%2C+Ji&rft.aulast=Gao&rft.aufirst=Ji&rft.date=2010-05-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Chemotactic+Cytokines&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=chemotac LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The NIH MRI Study of Normal Brain Development T2 - 22nd Annual Convention of the Association for Psychological Science (APS 2010) AN - 754301208; 5851873 JF - 22nd Annual Convention of the Association for Psychological Science (APS 2010) AU - Freund, Lisa Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 KW - Brain KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754301208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=22nd+Annual+Convention+of+the+Association+for+Psychological+Science+%28APS+2010%29&rft.atitle=The+NIH+MRI+Study+of+Normal+Brain+Development&rft.au=Freund%2C+Lisa&rft.aulast=Freund&rft.aufirst=Lisa&rft.date=2010-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=22nd+Annual+Convention+of+the+Association+for+Psychological+Science+%28APS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.psychologicalscience.org/convention/program_2010/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Teaching about Neuropathic Pain to Health Professionals Using Low Cost Educational Methods T2 - 3rd International Congress on Neuropathic Pain AN - 754298551; 5850583 JF - 3rd International Congress on Neuropathic Pain AU - Desai, G AU - Chaturvedi, S Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 KW - Pain KW - Neuropathy KW - Education KW - Experts KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754298551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+International+Congress+on+Neuropathic+Pain&rft.atitle=Teaching+about+Neuropathic+Pain+to+Health+Professionals+Using+Low+Cost+Educational+Methods&rft.au=Desai%2C+G%3BChaturvedi%2C+S&rft.aulast=Desai&rft.aufirst=G&rft.date=2010-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+International+Congress+on+Neuropathic+Pain&rft.issn=&rft_id=info:doi/ L2 - http://www.sessionplan.com/neupsig2010/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Harmful Consequences of Comparative Over-Optimism and How to Reduce Them T2 - 22nd Annual Convention of the Association for Psychological Science (APS 2010) AN - 754292293; 5852997 JF - 22nd Annual Convention of the Association for Psychological Science (APS 2010) AU - Klein, William AU - Dillard, Amanda Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754292293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=22nd+Annual+Convention+of+the+Association+for+Psychological+Science+%28APS+2010%29&rft.atitle=Harmful+Consequences+of+Comparative+Over-Optimism+and+How+to+Reduce+Them&rft.au=Klein%2C+William%3BDillard%2C+Amanda&rft.aulast=Klein&rft.aufirst=William&rft.date=2010-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=22nd+Annual+Convention+of+the+Association+for+Psychological+Science+%28APS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.psychologicalscience.org/convention/program_2010/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The NIMH Research Domain Criteria Project: Revolution in Psychopathology Classification? T2 - 22nd Annual Convention of the Association for Psychological Science (APS 2010) AN - 754291038; 5852305 JF - 22nd Annual Convention of the Association for Psychological Science (APS 2010) AU - Cuthbert, Bruce Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 KW - Classification KW - Psychopathology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754291038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=22nd+Annual+Convention+of+the+Association+for+Psychological+Science+%28APS+2010%29&rft.atitle=The+NIMH+Research+Domain+Criteria+Project%3A+Revolution+in+Psychopathology+Classification%3F&rft.au=Cuthbert%2C+Bruce&rft.aulast=Cuthbert&rft.aufirst=Bruce&rft.date=2010-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=22nd+Annual+Convention+of+the+Association+for+Psychological+Science+%28APS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.psychologicalscience.org/convention/program_2010/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Effect of Self-Affirmation on Subsequent Implementation Intentions for Health Behavior Change T2 - 22nd Annual Convention of the Association for Psychological Science (APS 2010) AN - 754290655; 5852675 JF - 22nd Annual Convention of the Association for Psychological Science (APS 2010) AU - Klein, William AU - Shmueli, Dikla AU - Bergman, Hannah AU - Ferrer, Rebecca AU - Harris, Peter Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 KW - Motivation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754290655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=22nd+Annual+Convention+of+the+Association+for+Psychological+Science+%28APS+2010%29&rft.atitle=The+Effect+of+Self-Affirmation+on+Subsequent+Implementation+Intentions+for+Health+Behavior+Change&rft.au=Klein%2C+William%3BShmueli%2C+Dikla%3BBergman%2C+Hannah%3BFerrer%2C+Rebecca%3BHarris%2C+Peter&rft.aulast=Klein&rft.aufirst=William&rft.date=2010-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=22nd+Annual+Convention+of+the+Association+for+Psychological+Science+%28APS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.psychologicalscience.org/convention/program_2010/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Functional Architecture of Face Processing in the Primate Brain T2 - 22nd Annual Convention of the Association for Psychological Science (APS 2010) AN - 754290287; 5852808 JF - 22nd Annual Convention of the Association for Psychological Science (APS 2010) AU - Ungerleider, Leslie Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 KW - Brain architecture KW - Primates KW - Pattern recognition KW - Face KW - Functional anatomy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754290287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=22nd+Annual+Convention+of+the+Association+for+Psychological+Science+%28APS+2010%29&rft.atitle=Functional+Architecture+of+Face+Processing+in+the+Primate+Brain&rft.au=Ungerleider%2C+Leslie&rft.aulast=Ungerleider&rft.aufirst=Leslie&rft.date=2010-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=22nd+Annual+Convention+of+the+Association+for+Psychological+Science+%28APS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.psychologicalscience.org/convention/program_2010/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Adverse Childhood Experiences Impact Alcohol-Related Outcomes in Recently Detoxified Alcoholics T2 - 22nd Annual Convention of the Association for Psychological Science (APS 2010) AN - 754287819; 5852064 JF - 22nd Annual Convention of the Association for Psychological Science (APS 2010) AU - Issa, Julnar AU - Smith, Ashley AU - Crouss, Tess AU - Demarais, Michelle AU - Doty, Linda AU - Hommer, Daniel AU - George, David AU - Ramchandani, Vijay Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 KW - Children KW - Alcoholics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754287819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=22nd+Annual+Convention+of+the+Association+for+Psychological+Science+%28APS+2010%29&rft.atitle=Adverse+Childhood+Experiences+Impact+Alcohol-Related+Outcomes+in+Recently+Detoxified+Alcoholics&rft.au=Issa%2C+Julnar%3BSmith%2C+Ashley%3BCrouss%2C+Tess%3BDemarais%2C+Michelle%3BDoty%2C+Linda%3BHommer%2C+Daniel%3BGeorge%2C+David%3BRamchandani%2C+Vijay&rft.aulast=Issa&rft.aufirst=Julnar&rft.date=2010-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=22nd+Annual+Convention+of+the+Association+for+Psychological+Science+%28APS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.psychologicalscience.org/convention/program_2010/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - REVIVE - IT Trial Update T2 - 56th Annual Conference of the American Society for Artificial Internal Organs (ASAIO 2010) AN - 754228506; 5789533 JF - 56th Annual Conference of the American Society for Artificial Internal Organs (ASAIO 2010) AU - Baldwin, Timothy Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754228506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Conference+of+the+American+Society+for+Artificial+Internal+Organs+%28ASAIO+2010%29&rft.atitle=REVIVE+-+IT+Trial+Update&rft.au=Baldwin%2C+Timothy&rft.aulast=Baldwin&rft.aufirst=Timothy&rft.date=2010-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Conference+of+the+American+Society+for+Artificial+Internal+Organs+%28ASAIO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asaio.com/clientuploads/pdf/2010/2010%20ASAIOProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Effective, Broad Spectrum Control of Virulent Bacterial Infections Using Cationic DNA Liposome Complexes Combined with Bacterial Antigens AN - 746232092; 13091418 AB - Protection against virulent pathogens that cause acute, fatal disease is often hampered by development of microbial resistance to traditional chemotherapeutics. Further, most successful pathogens possess an array of immune evasion strategies to avoid detection and elimination by the host. Development of novel, immunomodulatory prophylaxes that target the host immune system, rather than the invading microbe, could serve as effective alternatives to traditional chemotherapies. Here we describe the development and mechanism of a novel pan-anti-bacterial prophylaxis. Using cationic liposome non-coding DNA complexes (CLDC) mixed with crude F. tularensis membrane protein fractions (MPF), we demonstrate control of virulent F. tularensis infection in vitro and in vivo. CLDC+MPF inhibited bacterial replication in primary human and murine macrophages in vitro. Control of infection in macrophages was mediated by both reactive nitrogen species (RNS) and reactive oxygen species (ROS) in mouse cells, and ROS in human cells. Importantly, mice treated with CLDC+MPF 3 days prior to challenge survived lethal intranasal infection with virulent F. tularensis. Similarly to in vitro observations, in vivo protection was dependent on the presence of RNS and ROS. Lastly, CLDC+MPF was also effective at controlling infections with Yersinia pestis, Burkholderia pseudomallei and Brucella abortus. Thus, CLDC+MPF represents a novel prophylaxis to protect against multiple, highly virulent pathogens. Conventional treatment of bacterial infections typically includes administration of antibiotics. However, many pathogens have developed spontaneous resistance to commonly used antibiotics. Development of new compounds that stimulate the host immune system to directly kill bacteria by mechanisms different from those utilized by antibiotics may serve as effective alternatives to antibiotic therapy. In this report, we describe a novel compound capable of controlling infections mediated by different, unrelated bacteria via the induction of host derived reactive oxygen and reactive nitrogen species. This compound is comprised of cationic liposome DNA complexes (CLDC) and crude membrane preparations (MPF) obtained from attenuated Francisella tularensis Live Vaccine Strain (LVS). Pretreatment of primary mouse or human cells limited replication of virulent F. tularensis, Burkholderia pseudomallei, Yersinia pestis and Brucella abortus in vitro. CLDC+MPF was also effective for controlling lethal pulmonary infections with virulent F. tularensis. Thus, CLDC+MPF represents a novel antimicrobial for treatment of lethal, acute, bacterial infections. JF - PLoS Pathogens AU - Ireland, Robin AU - Olivares-Zavaleta, Norma AU - Warawa, Jonathan M AU - Gherardini, Frank C AU - Jarrett, Clayton AU - Hinnebusch, BJoseph AU - Belisle, John T AU - Fairman, Jeffery AU - Bosio, Catharine M AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 USA VL - 6 IS - 5 SN - 1553-7366, 1553-7366 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Burkholderia pseudomallei KW - Macrophages KW - Bacteria KW - Replication KW - Immune system KW - Chemotherapy KW - Yersinia pestis KW - Francisella tularensis KW - reactive nitrogen species KW - Antibiotics KW - Membrane proteins KW - Pathogens KW - Infection KW - Liposomes KW - Immunomodulation KW - Antimicrobial agents KW - Reactive oxygen species KW - Lung KW - DNA KW - Prophylaxis KW - Brucella abortus KW - Vaccines KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746232092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Pathogens&rft.atitle=Effective%2C+Broad+Spectrum+Control+of+Virulent+Bacterial+Infections+Using+Cationic+DNA+Liposome+Complexes+Combined+with+Bacterial+Antigens&rft.au=Ireland%2C+Robin%3BOlivares-Zavaleta%2C+Norma%3BWarawa%2C+Jonathan+M%3BGherardini%2C+Frank+C%3BJarrett%2C+Clayton%3BHinnebusch%2C+BJoseph%3BBelisle%2C+John+T%3BFairman%2C+Jeffery%3BBosio%2C+Catharine+M&rft.aulast=Ireland&rft.aufirst=Robin&rft.date=2010-05-27&rft.volume=6&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Pathogens&rft.issn=15537366&rft_id=info:doi/10.1371%2Fjournal.ppat.1000921 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Macrophages; Replication; Chemotherapy; Immune system; Antibiotics; reactive nitrogen species; Pathogens; Membrane proteins; Infection; Immunomodulation; Liposomes; Antimicrobial agents; Reactive oxygen species; Lung; Prophylaxis; DNA; Vaccines; Burkholderia pseudomallei; Bacteria; Yersinia pestis; Brucella abortus; Francisella tularensis DO - http://dx.doi.org/10.1371/journal.ppat.1000921 ER - TY - JOUR T1 - Monkeys quickly learn and generalize visual categories without lateral prefrontal cortex. AN - 733135812; 20510855 AB - Categorization is a basic mental process that helps individuals distinguish among groups of negative and positive objects, e.g., poisons and nutrients, or predators and prey. Monkey experiments have suggested that lateral prefrontal cortex (LPFC) participates in learning and processing visual categories. However, in humans category specific visual agnosia follows inferior temporal cortex but not LPFC damage. Here, we use a new behavioral approach to show that both normal monkeys and those with bilateral removal of LPFC learn and generalize perceptual categories of related visual stimuli rapidly without explicit instruction. These results strongly indicate that visual categorization occurs at some earlier stage of feed-forward processing, presumably in temporal cortex, without top-down information from LPFC. Copyright 2010 Elsevier Inc. All rights reserved. JF - Neuron AU - Minamimoto, Takafumi AU - Saunders, Richard C AU - Richmond, Barry J AD - Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. minamoto@nirs.go.jp Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 SP - 501 EP - 507 VL - 66 IS - 4 KW - Index Medicus KW - Animals KW - Macaca mulatta KW - Photic Stimulation -- methods KW - Pattern Recognition, Visual -- classification KW - Learning -- physiology KW - Prefrontal Cortex -- physiology KW - Pattern Recognition, Visual -- physiology KW - Reaction Time -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733135812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=Monkeys+quickly+learn+and+generalize+visual+categories+without+lateral+prefrontal+cortex.&rft.au=Minamimoto%2C+Takafumi%3BSaunders%2C+Richard+C%3BRichmond%2C+Barry+J&rft.aulast=Minamimoto&rft.aufirst=Takafumi&rft.date=2010-05-27&rft.volume=66&rft.issue=4&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Neuron&rft.issn=1097-4199&rft_id=info:doi/10.1016%2Fj.neuron.2010.04.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-17 N1 - Date created - 2010-05-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Neuron. 2010 May 27;66(4):471-3 [20510850] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuron.2010.04.010 ER - TY - JOUR T1 - Cholera Toxin Regulates a Signaling Pathway Critical for the Expansion of Neural Stem Cell Cultures from the Fetal and Adult Rodent Brains AN - 746232360; 13091362 AB - New mechanisms that regulate neural stem cell (NSC) expansion will contribute to improved assay systems and the emerging regenerative approach that targets endogenous stem cells. Expanding knowledge on the control of stem cell self renewal will also lead to new approaches for targeting the stem cell population of cancers. Here we show that Cholera toxin regulates two recently characterized NSC markers, the Tie2 receptor and the transcription factor Hes3, and promotes the expansion of NSCs in culture. Cholera toxin increases immunoreactivity for the Tie2 receptor and rapidly induces the nuclear localization of Hes3. This is followed by powerful cultured NSC expansion and induction of proliferation both in the presence and absence of mitogen. Our data suggest a new cell biological mechanism that regulates the self renewal and differentiation properties of stem cells, providing a new logic to manipulate NSCs in the context of regenerative disease and cancer. JF - PLoS ONE AU - Androutsellis-Theotokis, Andreas AU - Walbridge, Stuart AU - Park, Deric M AU - Lonser, Russell R AU - McKay, Ronald DG AD - Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2010/05/26/ PY - 2010 DA - 2010 May 26 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - 5 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Data processing KW - Brain KW - Self KW - Cell culture KW - Fetuses KW - Cancer KW - Differentiation KW - Stem cells KW - Cholera toxin KW - Transcription factors KW - Immunoreactivity KW - Mitogens KW - Neural stem cells KW - Signal transduction KW - N3 11007:Neurobiology KW - W 30945:Fermentation & Cell Culture KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746232360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Cholera+Toxin+Regulates+a+Signaling+Pathway+Critical+for+the+Expansion+of+Neural+Stem+Cell+Cultures+from+the+Fetal+and+Adult+Rodent+Brains&rft.au=Androutsellis-Theotokis%2C+Andreas%3BWalbridge%2C+Stuart%3BPark%2C+Deric+M%3BLonser%2C+Russell+R%3BMcKay%2C+Ronald+DG&rft.aulast=Androutsellis-Theotokis&rft.aufirst=Andreas&rft.date=2010-05-26&rft.volume=5&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0010841 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Brain; Self; Cell culture; Cancer; Fetuses; Differentiation; Stem cells; Cholera toxin; Transcription factors; Immunoreactivity; Mitogens; Neural stem cells; Signal transduction DO - http://dx.doi.org/10.1371/journal.pone.0010841 ER - TY - JOUR T1 - Prospective randomized trial evaluating mandatory second look surgery with HIPEC and CRS vs. standard of care in patients at high risk of developing colorectal peritoneal metastases AN - 754867869; 13167220 AB - The standard of care for colorectal peritoneal carcinomatosis is evolving from chemotherapy to cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with disease limited to the peritoneum. Peritoneal carcinomatosis from colorectal cancer treated with chemotherapy alone results in median survival of 5 to 13 months, whereas CRS with HIPEC for early peritoneal carcinomatosis from colorectal cancer resulted in median survival of 48-63 months and 5 year survival of 51%. Completeness of cytoreduction and limited disease are associated with longer survival, yet early peritoneal carcinomatosis is undetectable by conventional imaging. Exploratory laparotomy can successfully identify early disease, but this approach can only be justified in patients with high risk of peritoneal carcinomatosis. Historical data indicates that patients presenting with synchronous peritoneal carcinomatosis, ovarian metastases, perforated primary tumor, and emergency presentation with bleeding or obstructing lesions are at high risk of peritoneal carcinomatosis. Approximately 55% of these patient populations will develop peritoneal carcinomatosis. We hypothesize that performing a mandatory second look laparotomy with CRS and HIPEC for patients who are at high risk for developing peritoneal carcinomatosis from colorectal cancer will lead to improved survival as compared to patients who receive standard of care with routine surveillance. This study is a prospective randomized trial designed to answer the question whether mandatory second look surgery with CRS and HIPEC will prolong overall survival compared to the standard of care in patients who are at high risk for developing peritoneal carcinomatosis from colorectal cancer (CRC). Patients with CRC at high risk for developing peritoneal carcinomatosis who underwent curative surgery and subsequently received standard of care adjuvant chemotherapy will be evaluated. The patients who remain without evidence of disease by imaging, physical examination, and tumor markers for 12 months after the primary operation will be randomized to mandatory second look surgery or standard-of-care surveillance. At laparotomy, CRS and HIPEC will be performed with intraperitoneal oxaliplatin with concurrent systemic 5-fluorouracil and leucovorin. Up to 100 patients will be enrolled to allow for 35 evaluable patients in each arm; accrual is expected to last 5 years. ClinicalTrials.gov ID: NCT01095523 JF - Trials AU - Ripley, Robert T AU - Davis, Jeremy L AU - Kemp, Clinton D AU - Steinberg, Seth M AU - Toomey, Mary Ann AU - Avital, Itzhak AD - Surgery Branch, CCR, NCI, Bethesda, MD 20892-120, USA Y1 - 2010/05/25/ PY - 2010 DA - 2010 May 25 SP - 62 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 11 KW - Risk Abstracts KW - Historical account KW - tumors KW - surgery KW - chemotherapy KW - colorectal carcinoma KW - Lesions KW - survival KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754867869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trials&rft.atitle=Prospective+randomized+trial+evaluating+mandatory+second+look+surgery+with+HIPEC+and+CRS+vs.+standard+of+care+in+patients+at+high+risk+of+developing+colorectal+peritoneal+metastases&rft.au=Ripley%2C+Robert+T%3BDavis%2C+Jeremy+L%3BKemp%2C+Clinton+D%3BSteinberg%2C+Seth+M%3BToomey%2C+Mary+Ann%3BAvital%2C+Itzhak&rft.aulast=Ripley&rft.aufirst=Robert&rft.date=2010-05-25&rft.volume=11&rft.issue=&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Trials&rft.issn=1745-6215&rft_id=info:doi/10.1186%2F1745-6215-11-62 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Historical account; colorectal carcinoma; Lesions; tumors; survival; chemotherapy; surgery DO - http://dx.doi.org/10.1186/1745-6215-11-62 ER - TY - CPAPER T1 - Magnetic resonance spectroscopy may be helpful in acute stroke T2 - 19th European Stroke Conference (ESC 2010) AN - 754304250; 5855744 JF - 19th European Stroke Conference (ESC 2010) AU - Dani, K AU - An, L. AU - Henning, E AU - Shen, J AU - Warach, S Y1 - 2010/05/25/ PY - 2010 DA - 2010 May 25 KW - Spectroscopy KW - Stroke KW - Magnetic resonance spectroscopy KW - Resonance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754304250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+European+Stroke+Conference+%28ESC+2010%29&rft.atitle=Magnetic+resonance+spectroscopy+may+be+helpful+in+acute+stroke&rft.au=Dani%2C+K%3BAn%2C+L.%3BHenning%2C+E%3BShen%2C+J%3BWarach%2C+S&rft.aulast=Dani&rft.aufirst=K&rft.date=2010-05-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+European+Stroke+Conference+%28ESC+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eurostroke.org/bar_prog_overview.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - SDF-1alpha correlates with circulating endothelial progenitor cells and with acute lesion volume in stroke patients T2 - 19th European Stroke Conference (ESC 2010) AN - 754300041; 5855400 JF - 19th European Stroke Conference (ESC 2010) AU - Bogoslovsky, T AU - Spatz, M AU - Chaudhry, A AU - Maric, D AU - Luby, M AU - Frank, J AU - Warach, S Y1 - 2010/05/25/ PY - 2010 DA - 2010 May 25 KW - Lesions KW - Stroke KW - Stem cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754300041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+European+Stroke+Conference+%28ESC+2010%29&rft.atitle=SDF-1alpha+correlates+with+circulating+endothelial+progenitor+cells+and+with+acute+lesion+volume+in+stroke+patients&rft.au=Bogoslovsky%2C+T%3BSpatz%2C+M%3BChaudhry%2C+A%3BMaric%2C+D%3BLuby%2C+M%3BFrank%2C+J%3BWarach%2C+S&rft.aulast=Bogoslovsky&rft.aufirst=T&rft.date=2010-05-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+European+Stroke+Conference+%28ESC+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eurostroke.org/bar_prog_overview.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Family history of cancer and renal cell cancer risk in Caucasians and African Americans AN - 745937784; 12951650 AB - Background:The association between renal cell carcinoma (RCC) risk and family history of cancer has not been examined with an adequate number of African Americans (AAs). Methods:In a population-based case-control study, unconditional logistic regression was used to calculate the association between RCC risk and a family history of cancer among 1217 RCC cases and 1235 controls. Results:Increased RCC risk was shown for subjects with at least one first-degree relative with kidney cancer (odds ratio=2.29; 95% confidence interval=1.31-4.00). No differences in risk were observed when analyses were stratified by race. For Caucasians, excess risk was observed among those reporting a sibling with kidney cancer, whereas for AAs, increased risk occurred among subjects reporting either a sibling or parent affected with the disease. A family history of non-renal cancers, and those related to smoking or to the von Hippel-Lindau syndrome, revealed no association with RCC risk. Conclusion:The RCC risk associated with a family history of kidney cancer is similar among Caucasians and AAs. JF - British Journal of Cancer AU - Karami, S AU - Schwartz, K AU - Purdue, M P AU - Davis, F G AU - Ruterbusch, J J AU - Munuo, S S AU - Wacholder, S AU - Graubard, B I AU - Colt, J S AU - Chow, W-H AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7242, Bethesda, MD 20892-7242, USA Y1 - 2010/05/25/ PY - 2010 DA - 2010 May 25 SP - 1676 EP - 1680 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 102 IS - 11 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Genetics KW - Smoking KW - Kidney KW - Africa KW - siblings KW - Cancer KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745937784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Family+history+of+cancer+and+renal+cell+cancer+risk+in+Caucasians+and+African+Americans&rft.au=Karami%2C+S%3BSchwartz%2C+K%3BPurdue%2C+M+P%3BDavis%2C+F+G%3BRuterbusch%2C+J+J%3BMunuo%2C+S+S%3BWacholder%2C+S%3BGraubard%2C+B+I%3BColt%2C+J+S%3BChow%2C+W-H&rft.aulast=Karami&rft.aufirst=S&rft.date=2010-05-25&rft.volume=102&rft.issue=11&rft.spage=1676&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605680 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Smoking; Genetics; Kidney; siblings; Ethnic groups; Cancer; Africa DO - http://dx.doi.org/10.1038/sj.bjc.6605680 ER - TY - JOUR T1 - Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer. AN - 733105893; 20424609 AB - Side population (SP) fraction cells, identified by efflux of Hoechst dye, are present in virtually all normal and malignant tissues. The relationship between SP cells, drug resistance and cancer stem cells is poorly understood. Small-cell lung cancer (SCLC) is a highly aggressive human tumour with a 5-year survival rate of <10%. These features suggest enrichment in cancer stem cells. We examined several SCLC cell lines and found that they contain a consistent SP fraction that comprises <1% of the bulk population. Side population cells have higher proliferative capacity in vitro, efficient self-renewal and reduced cell surface expression of neuronal differentiation markers, CD56 and CD90, as compared with non-SP cells. Previous reports indicated that several thousand SP cells from non-small-cell lung cancer are required to form tumours in mice. In contrast, as few as 50 SP cells from H146 and H526 SCLC cell lines rapidly reconstituted tumours. Whereas non-SP cells formed fewer and slower-growing tumours, SP cells over-expressed many genes associated with cancer stem cell and drug resistance: ABCG2, FGF1, IGF1, MYC, SOX1/2, WNT1, as well as genes involved in angiogenesis, Notch and Hedgehog pathways. Side population cells from SCLC are highly enriched in tumourigenic cells and are characterised by a specific stem cell-associated gene expression signature. This gene signature may be used for development of targeted therapies for this rapidly fatal tumour. JF - British journal of cancer AU - Salcido, C D AU - Larochelle, A AU - Taylor, B J AU - Dunbar, C E AU - Varticovski, L AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA. Y1 - 2010/05/25/ PY - 2010 DA - 2010 May 25 SP - 1636 EP - 1644 VL - 102 IS - 11 KW - Antigens, Surface KW - 0 KW - Biomarkers, Tumor KW - Index Medicus KW - Animals KW - Biomarkers, Tumor -- genetics KW - Mice, Inbred NOD KW - Humans KW - Mice KW - Cell Line, Tumor KW - Cell Separation KW - Antigens, Surface -- genetics KW - Validation Studies as Topic KW - Biomarkers, Tumor -- metabolism KW - Gene Expression Regulation, Neoplastic KW - Gene Expression Profiling KW - Biomarkers, Tumor -- analysis KW - Mice, SCID KW - Antigens, Surface -- metabolism KW - Male KW - Antigens, Surface -- analysis KW - Small Cell Lung Carcinoma -- pathology KW - Neoplastic Stem Cells -- pathology KW - Small Cell Lung Carcinoma -- genetics KW - Lung Neoplasms -- genetics KW - Neoplastic Stem Cells -- metabolism KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733105893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+cancer&rft.atitle=Molecular+characterisation+of+side+population+cells+with+cancer+stem+cell-like+characteristics+in+small-cell+lung+cancer.&rft.au=Salcido%2C+C+D%3BLarochelle%2C+A%3BTaylor%2C+B+J%3BDunbar%2C+C+E%3BVarticovski%2C+L&rft.aulast=Salcido&rft.aufirst=C&rft.date=2010-05-25&rft.volume=102&rft.issue=11&rft.spage=1636&rft.isbn=&rft.btitle=&rft.title=British+journal+of+cancer&rft.issn=1532-1827&rft_id=info:doi/10.1038%2Fsj.bjc.6605668 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-17 N1 - Date created - 2010-05-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Cell Biol. 2005 Sep;15(9):494-501 [16084092] Cancer Res. 2005 Jul 1;65(13):5506-11 [15994920] Cancer Res. 2005 Dec 1;65(23):10946-51 [16322242] Nat Rev Drug Discov. 2006 Mar;5(3):219-34 [16518375] Oncogene. 2006 Mar 16;25(12):1696-708 [16449977] Stem Cells. 2006 Apr;24(4):1065-74 [16282442] Stem Cells. 2006 Apr;24(4):965-74 [16282445] Lung Cancer. 2006 Jun;52(3):281-90 [16616798] Cancer Res. 2006 Aug 1;66(15):7445-52 [16885340] Blood. 2006 Oct 15;108(8):2850-6 [16804114] Science. 2006 Oct 13;314(5797):268-74 [16959974] Exp Cell Res. 2006 Nov 15;312(19):3701-10 [17046749] Mol Cancer. 2006;5:67 [17140455] Cancer Metastasis Rev. 2007 Mar;26(1):39-57 [17323127] Clin Cancer Res. 2007 Apr 1;13(7):2168-77 [17404101] Lung Cancer. 2007 May;56(2):207-15 [17258349] Cancer Res. 2007 May 15;67(10):4827-33 [17510412] Science. 2007 Jul 20;317(5836):337 [17641192] Cancer Sci. 2007 Oct;98(10):1512-20 [17645776] Stem Cell Rev. 2007 Jun;3(2):169-75 [17873349] Stem Cell Rev. 2007 Dec;3(4):249-55 [17955391] J Pathol. 2008 Jan;214(1):3-9 [18067118] Cell Death Differ. 2008 Mar;15(3):504-14 [18049477] Breast Cancer Res. 2008;10(1):R10 [18241344] BMC Cancer. 2008;8:176 [18570671] Stem Cells. 2008 Jul;26(7):1818-30 [18467664] Nature. 2008 Dec 4;456(7222):593-8 [19052619] CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49 [19474385] Clin Cancer Res. 2002 Jan;8(1):22-8 [11801536] Annu Rev Immunol. 2003;21:759-806 [12615892] Nature. 2003 Mar 20;422(6929):313-7 [12629553] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 [12629218] Oncogene. 2004 Sep 20;23(43):7274-82 [15378087] Science. 1977 Jul 29;197(4302):461-3 [560061] J Exp Med. 1996 Apr 1;183(4):1797-806 [8666936] Exp Cell Res. 2005 Feb 15;303(2):360-74 [15652349] Nat Genet. 2005 Oct;37(10):1125-9 [16142234] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/sj.bjc.6605668 ER - TY - CPAPER T1 - Characterization of PET Radiotracers Through LC-MS/MS Measurement of the Radiotracer and Accompanying [13C]Carrier T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839676906; 5919548 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Shetty, Umesha AU - Morse, Cheryl AU - Zhang, Yi AU - Pike, Victor Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839676906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Characterization+of+PET+Radiotracers+Through+LC-MS%2FMS+Measurement+of+the+Radiotracer+and+Accompanying+%5B13C%5DCarrier&rft.au=Shetty%2C+Umesha%3BMorse%2C+Cheryl%3BZhang%2C+Yi%3BPike%2C+Victor&rft.aulast=Shetty&rft.aufirst=Umesha&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Determining the site of spin trapping and protein cross-linking of the bovine lactoperoxidase protein radical by mass spectrometry T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839675171; 5919284 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Lardinois, Olivier AU - Mason, Ronald AU - Tomer, Kenneth AU - Deterding, Leesa Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Mass spectroscopy KW - Radicals KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839675171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Determining+the+site+of+spin+trapping+and+protein+cross-linking+of+the+bovine+lactoperoxidase+protein+radical+by+mass+spectrometry&rft.au=Lardinois%2C+Olivier%3BMason%2C+Ronald%3BTomer%2C+Kenneth%3BDeterding%2C+Leesa&rft.aulast=Lardinois&rft.aufirst=Olivier&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - ATP Binding Cassette Transporter A1 Regulates the Lipid Raft Proteome of the Resting and Lipopolysaccharide-stimulated Macrophage T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839673794; 5919961 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Chowdhury, Saiful AU - Zhu, Xuewei AU - Williams, Jason AU - Deterding, Leesa AU - Merrick, B AU - Parks, John AU - Tomer, Kenneth AU - Fessler, Michael Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Lipid rafts KW - ATP KW - Macrophages KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839673794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=ATP+Binding+Cassette+Transporter+A1+Regulates+the+Lipid+Raft+Proteome+of+the+Resting+and+Lipopolysaccharide-stimulated+Macrophage&rft.au=Chowdhury%2C+Saiful%3BZhu%2C+Xuewei%3BWilliams%2C+Jason%3BDeterding%2C+Leesa%3BMerrick%2C+B%3BParks%2C+John%3BTomer%2C+Kenneth%3BFessler%2C+Michael&rft.aulast=Chowdhury&rft.aufirst=Saiful&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Quantitative analysis of phospholipids using NALDI target plates T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839668362; 5921302 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Colantonio, Simona AU - Simpson, Jack AU - Fisher, Robert AU - Puri, Anu AU - Yavlovich, Amichai AU - Blumenthal, Robert AU - Belanger, Julie Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Quantitative analysis KW - Phospholipids KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839668362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Quantitative+analysis+of+phospholipids+using+NALDI+target+plates&rft.au=Colantonio%2C+Simona%3BSimpson%2C+Jack%3BFisher%2C+Robert%3BPuri%2C+Anu%3BYavlovich%2C+Amichai%3BBlumenthal%2C+Robert%3BBelanger%2C+Julie&rft.aulast=Colantonio&rft.aufirst=Simona&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - NCI's Clinical Proteomic Technologies for Cancer - Building a Robust and Reliable Cancer Protein Biomarker Development Pipeline T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839667594; 5921118 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Rahbar, Amir AU - Boja, Emily AU - Hiltke, Tara AU - Kinsinger, Chris AU - Mesri, Mehdi AU - Rivers, Robert AU - Rodriguez, Henry Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Cancer KW - Bioindicators KW - Pipelines KW - Technology KW - Proteomics KW - Biomarkers KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839667594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=NCI%27s+Clinical+Proteomic+Technologies+for+Cancer+-+Building+a+Robust+and+Reliable+Cancer+Protein+Biomarker+Development+Pipeline&rft.au=Rahbar%2C+Amir%3BBoja%2C+Emily%3BHiltke%2C+Tara%3BKinsinger%2C+Chris%3BMesri%2C+Mehdi%3BRivers%2C+Robert%3BRodriguez%2C+Henry&rft.aulast=Rahbar&rft.aufirst=Amir&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Plasma Pharmacokinetics of NSC 742410, a Novel Dinucleotide Multidrug, in Mice T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839666818; 5921394 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Phillips, Lawrence AU - Carter, John AU - Majerova, Eva AU - Hollingshead, Melinda Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Mice KW - Pharmacokinetics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839666818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Plasma+Pharmacokinetics+of+NSC+742410%2C+a+Novel+Dinucleotide+Multidrug%2C+in+Mice&rft.au=Phillips%2C+Lawrence%3BCarter%2C+John%3BMajerova%2C+Eva%3BHollingshead%2C+Melinda&rft.aulast=Phillips&rft.aufirst=Lawrence&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Progress In Standardizing Mass Spectrometry-based Platforms via Inter-laboratory Studies From Discovery to Verification (NCI-CPTAC Network Studies) T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839665731; 5921127 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Boja, Emily AU - Rahbar, Amir AU - Kinsinger, Christopher AU - Mesri, Mehdi AU - Hiltke, Tara AU - Rivers, Robert AU - Rodriguez, Henry Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839665731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Progress+In+Standardizing+Mass+Spectrometry-based+Platforms+via+Inter-laboratory+Studies+From+Discovery+to+Verification+%28NCI-CPTAC+Network+Studies%29&rft.au=Boja%2C+Emily%3BRahbar%2C+Amir%3BKinsinger%2C+Christopher%3BMesri%2C+Mehdi%3BHiltke%2C+Tara%3BRivers%2C+Robert%3BRodriguez%2C+Henry&rft.aulast=Boja&rft.aufirst=Emily&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Characterization of Chondroitin Sulfate Using High Resolution Ion Trap-Time of Flight (IT-TOF) Mass Spectrometry T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839665661; 5920638 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Katagiri, Hiro AU - Geller, Herbert AU - Hays, Faith AU - Wang, Yuhui AU - Hedgepeth, William AU - Takahashi, Masatoshi Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Mass spectroscopy KW - Sulfate KW - Chondroitin sulfate KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839665661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Characterization+of+Chondroitin+Sulfate+Using+High+Resolution+Ion+Trap-Time+of+Flight+%28IT-TOF%29+Mass+Spectrometry&rft.au=Katagiri%2C+Hiro%3BGeller%2C+Herbert%3BHays%2C+Faith%3BWang%2C+Yuhui%3BHedgepeth%2C+William%3BTakahashi%2C+Masatoshi&rft.aulast=Katagiri&rft.aufirst=Hiro&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Beyond Monoisotopic Mass II : Prediction of Peptide PTMs by Isotope Cluster Analysis T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839664040; 5920342 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Yergey, Alfred AU - Epstein, Jonathan AU - Olson, Matthew AU - Backlund, Peter AU - Blank, Paul AU - Catlin, Aaron Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Isotopes KW - Peptides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839664040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Beyond+Monoisotopic+Mass+II+%3A+Prediction+of+Peptide+PTMs+by+Isotope+Cluster+Analysis&rft.au=Yergey%2C+Alfred%3BEpstein%2C+Jonathan%3BOlson%2C+Matthew%3BBacklund%2C+Peter%3BBlank%2C+Paul%3BCatlin%2C+Aaron&rft.aulast=Yergey&rft.aufirst=Alfred&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Development of a New Flow Cell System for Short-Duration Oxidative Protein Footprinting using Ultraviolet Laser Flash Photolysis T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839662632; 5921041 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Sampson, Jason AU - Wang, Jinglan AU - Smedley, III, James AU - Tomer, Kenneth Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Photolysis KW - U.V. radiation KW - Lasers KW - Footprinting KW - Flash photolysis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839662632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Development+of+a+New+Flow+Cell+System+for+Short-Duration+Oxidative+Protein+Footprinting+using+Ultraviolet+Laser+Flash+Photolysis&rft.au=Sampson%2C+Jason%3BWang%2C+Jinglan%3BSmedley%2C+III%2C+James%3BTomer%2C+Kenneth&rft.aulast=Sampson&rft.aufirst=Jason&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - A Mass Spectrometric Method to Monitor Phosphatidylserine Remodeling in Living Cells Using Labeled Serine and Fatty Acids T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839658115; 5919338 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Kevala, Karl AU - Kimura, Atsuko AU - Kim, Hee-Yong Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Fatty acids KW - Serine KW - Phosphatidylserine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839658115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=A+Mass+Spectrometric+Method+to+Monitor+Phosphatidylserine+Remodeling+in+Living+Cells+Using+Labeled+Serine+and+Fatty+Acids&rft.au=Kevala%2C+Karl%3BKimura%2C+Atsuko%3BKim%2C+Hee-Yong&rft.aulast=Kevala&rft.aufirst=Karl&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER -